[{"hash":"672728718440096613","title":"BMP-driven bone and cartilage formation","description":"The cluster shows strong enrichment for BMP signaling, osteoblast differentiation, and cartilage condensation, pointing to skeletal development and endochondral ossification as the main theme. While there are additional terms like lung development and dexamethasone response, they do not outweigh the core bone/cartilage signals.","confidence":"High","size":29,"edges":101,"triangles":177,"max_degree":20,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007565","count":6},{"id":"GO:0007596","count":5},{"id":"GO:0071549","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0000122","count":4}]},{"hash":"423649140879765970","title":"Microtubule-driven spindle assembly and nuclear migration","description":"The set of top GO terms centers on microtubule cytoskeleton dynamics and chromosome movement\u2014minus-end directed microtubule sliding, mitotic metaphase chromosome alignment, establishment of meiotic spindle orientation, and nuclear migration/karyogamy. Development-related terms like root development and ureteric bud invasion also imply microtubule roles in growth and organogenesis, suggesting a cohesive theme around microtubule-mediated nuclear and chromosome dynamics during cell division and development.","confidence":"High","size":29,"edges":298,"triangles":1856,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0032487","count":29},{"id":"GO:0031534","count":29},{"id":"GO:0000742","count":29},{"id":"GO:0007080","count":29},{"id":"GO:0000743","count":29}]},{"hash":"1479598313433950481","title":"Neuronal signaling and plasticity","description":"The top GO terms cluster around neural activity: sodium/potassium ion transmembrane transport, excitatory postsynaptic potential, GABA signaling, locomotory behavior, and conditioned taste aversion, with receptor internalization pointing to synaptic receptor trafficking and plasticity. A few unrelated terms (cell wall/peptidoglycan catabolism, viral release) may reflect annotation noise, but the dominant theme is neuronal signaling and learning-related synaptic changes.","confidence":"High","size":29,"edges":45,"triangles":22,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":15},{"id":"GO:0035725","count":14},{"id":"GO:0071805","count":13},{"id":"GO:0060079","count":13},{"id":"GO:0007214","count":12}]},{"hash":"1100404461676070798","title":"Immune cell adhesion and signaling","description":"The cluster is dominated by GO terms for cell-cell adhesion (heterophilic 15, homophilic 13) and multiple immune-related processes (complement activation 13, innate immune response 12, B cell receptor signaling 12, phagocytosis 12, and regulation of cytotoxic activities). This combination points to proteins mediating leukocyte adhesion and signaling across innate and adaptive immunity, with regulatory roles on cytotoxic functions.","confidence":"High","size":29,"edges":223,"triangles":620,"max_degree":21,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0006958","count":13},{"id":"GO:0007156","count":13},{"id":"GO:0043031","count":12},{"id":"GO:0002859","count":12}]},{"hash":"421712509339125274","title":"Cytoskeleton remodeling and mechanotransduction signaling","description":"The top GO terms point to actin cytoskeleton dynamics (ruffle assembly, cell spreading), membrane trafficking (endocytosis), and mechanosensitive signaling (cell response to mechanical stimulus, GTPase regulation). These together suggest a functional cluster centered on cytoskeletal remodeling and mechanotransduction pathways, rather than a single tissue-specific role; the heart development term may be incidental. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0097178","count":7},{"id":"GO:0006897","count":7},{"id":"GO:1900026","count":7}]},{"hash":"594415295057063132","title":"Neuronal signaling and gene regulation","description":"This cluster\u2019s top GO terms point to neuronal communication and behavior (glutamatergic synaptic transmission, excitatory postsynaptic potential, social/grooming/vocalization behaviors) along with Rho-mediated signaling and some transcriptional regulation, suggesting a mode where neural activity is linked to gene expression control.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:2000463","count":3},{"id":"GO:0035176","count":3},{"id":"GO:2000821","count":3},{"id":"GO:0071625","count":3}]},{"hash":"597109726619484320","title":"Neuronal Signaling and Sensory Processing","description":"The listed GO terms cluster around neuronal communication and sensory responses: ion transport across membranes (Na+, K+, Ca2+), GABA signaling, excitatory postsynaptic potentials, locomotory behavior, taste aversion, and sensory detection of sound, plus related exocytosis processes like the acrosome reaction. Together they point to neural signaling pathways that regulate behavior and sensory perception, with calcium and ions as key mediators of neurotransmitter release. Therefore the label \u201cNeuronal Signaling and Sensory Processing\u201d is appropriate.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":11},{"id":"GO:0035725","count":11},{"id":"GO:0071805","count":11},{"id":"GO:0007214","count":11},{"id":"GO:0060079","count":11}]},{"hash":"395739763769000404","title":"Developmental signaling and cytoskeletal dynamics","description":"The proteins are enriched for intercellular signaling pathways (T cell receptor signaling, ROBO, Ephrin) and cytoskeletal regulation (actin reorganization, protein stability), plus development-related terms like nervous system development, suggesting a cohesive role in signaling-driven development and cytoskeletal remodeling. A few cell-cycle terms are present but do not dominate the theme. ","confidence":"High","size":29,"edges":230,"triangles":793,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":26},{"id":"GO:0050852","count":24},{"id":"GO:0007399","count":24},{"id":"GO:0000056","count":23},{"id":"GO:0000186","count":23}]},{"hash":"546312056611010865","title":"Neuronal development, synaptic organization, and mitochondrial dynamics","description":"Proteins in this cluster are enriched for neuronal development markers (neuron projection development, memory), synaptic organization (positive regulation of protein localization to synapse), and cytoskeletal/mitochondrial dynamics (microtubule polymerization/sliding, intracellular distribution of mitochondria, regulation of mitochondrial fission). The presence of potassium ion transport and sensory perception of sound also points to neuronal excitability and auditory function. Together, the terms suggest a coherent theme of neuronal development and synaptic maintenance with mitochondria dynamics.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031175","count":5},{"id":"GO:0071805","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0031116","count":4},{"id":"GO:1900034","count":4}]},{"hash":"1582149153457990162","title":"Post-transcriptional mRNA processing and stability regulation","description":"The cluster is dominated by GO terms related to regulation of mRNA stability, alternative splicing via the spliceosome, splicing site recognition, mRNA modification, and mRNA stabilization, with an additional note of translation initiation factor complex assembly (eIF4F). Together these suggest coordinated post-transcriptional control of mRNA maturation, processing, stability, and translation, especially under stress. ","confidence":"High","size":29,"edges":405,"triangles":3627,"max_degree":28,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":26},{"id":"GO:0000381","count":17},{"id":"GO:1905663","count":15},{"id":"GO:0097010","count":15},{"id":"GO:0016556","count":15}]},{"hash":"2070385680822054189","title":"GPCR-opsin signaling and visual perception","description":"These proteins are annotated with multiple GPCR-related terms, including G protein-coupled receptor signaling and the opsin signaling pathway, along with visual perception. This suggests a core role in GPCR-mediated signaling tied to vision, with some related neural signaling context (e.g., enteric nervous system development). The outliers (e.g., blood coagulation, cell wall catabolic processes) are likely incidental or misannotations, but do not outweigh the dominant GPCR/opsin-vision theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048484","count":12},{"id":"GO:0045745","count":12},{"id":"GO:0016056","count":12},{"id":"GO:0007601","count":12},{"id":"GO:0007596","count":12}]},{"hash":"35577776321738673","title":"Yeast cytokinesis and ribosome biogenesis","description":"The cluster is dominated by yeast-like cell division processes: cell division, mitotic cell cycle, division septum/neck localization, and maintenance of cell polarity, paired with ribosome biogenesis and cytoplasmic translation, suggesting coordinated protein synthesis during budding. Some terms (neuron projection development, non-motile cilium assembly) appear less related and may reflect cross-species annotations, but the core signal clearly points to budding yeast cell division and ribosome assembly.","confidence":"High","size":29,"edges":31,"triangles":10,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0042254","count":6},{"id":"GO:0000747","count":6},{"id":"GO:0031175","count":6},{"id":"GO:0000278","count":6}]},{"hash":"237012113478666232","title":"Neuronal signaling and cytoskeletal regulation","description":"The cluster\u2019s top GO terms center on neural communication (GABAergic synaptic transmission) and signaling pathways (ephrin receptor signaling), together with cytoskeletal remodeling (stress fiber assembly regulation, actin cytoskeleton reorganization) and phosphorylation regulation. This points to a cohesive theme of neuronal connectivity and cytoskeletal dynamics, though a couple terms (spermatid development, mitotic cell cycle) may be incidental. ","confidence":"Medium","size":29,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007286","count":10},{"id":"GO:0000278","count":10},{"id":"GO:0051496","count":8},{"id":"GO:0043525","count":8},{"id":"GO:0043552","count":8}]},{"hash":"2005606851193884572","title":"Rac-JNK\u2013mediated actin remodeling and cell motility","description":"This cluster is dominated by Rac signaling, JNK cascade regulation, and actin cytoskeleton remodeling processes (including filopodium assembly and cell spreading), all pointing to mechanotransduction and cytoskeletal-driven motility. A secondary immune term appears, but the core signal centers on Rac/JNK\u2013mediated actin dynamics and movement.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0016601","count":4},{"id":"GO:0043124","count":4},{"id":"GO:0071260","count":4}]},{"hash":"874380099985218024","title":"Wnt-driven organogenesis and transcriptional regulation","description":"This cluster is dominated by GO terms centered on Wnt signaling and developmental processes (pancreas morphogenesis, midbrain development, multicellular growth, angiogenesis), with accompanying transcriptional regulation terms (negative regulation and DNA-templated transcription). While some immune-response terms appear, the core theme ties to signaling-driven organogenesis and gene expression control, making this an apt, specific label.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0032496","count":9},{"id":"GO:0030901","count":9},{"id":"GO:0043046","count":8},{"id":"GO:0001878","count":8}]},{"hash":"2134417027167029560","title":"Enteric neural signaling and gut motility","description":"The top terms point to enteric nervous system development and peristalsis, with GPCR signaling (including adenylate cyclase-activating pathways) and downstream ERK cascades driving gut motility. While inflammatory, blood pressure, xenobiotic response, and energy metabolism terms are present, the strongest theme is enteric neuronal signaling governing peristaltic activity, suggesting these proteins mainly function in enteric neural signaling and gut motility regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048484","count":12},{"id":"GO:0030432","count":12},{"id":"GO:0035625","count":12},{"id":"GO:0006954","count":12},{"id":"GO:0043547","count":12}]},{"hash":"1330334857987217583","title":"Pain and Temperature Sensory Response","description":"The top GO terms are dominated by pain perception and temperature-related responses (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis), with accompanying neural signaling and autonomic regulation terms (membrane potential, dopamine signaling, adenylate cyclase activity, muscle relaxation). This points to a coherent theme around nociceptive and thermosensory pathways and their modulation, justifying a label focused on pain and temperature sensory response.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":25},{"id":"GO:0002024","count":25},{"id":"GO:0071502","count":25},{"id":"GO:0042391","count":21},{"id":"GO:0046541","count":21}]},{"hash":"1706771885444840749","title":"Neural Pain Signaling and Thermogenic Regulation","description":"The terms cluster around neural signaling and sensory perception (pain, neuropeptide signaling, phototransduction) with downstream physiological responses including calcium signaling, thermogenesis, eating behavior, and inflammatory/defense responses. This suggests a shared theme of neural regulation linking pain sensation with feeding, temperature responses, and inflammation, hence the label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0051281","count":9},{"id":"GO:0007603","count":9},{"id":"GO:0007218","count":9},{"id":"GO:0051209","count":9}]},{"hash":"330555950119831179","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0019233","count":17},{"id":"GO:0008542","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0046541","count":16}]},{"hash":"391810869706355735","title":"GPCR-Regulated Neurotransmitter Signaling","description":"The top GO terms cluster around G protein-coupled receptor signaling and its regulation\u2014particularly dopaminergic and cholinergic pathways, including negative regulation of adenylate cyclase and dopamine signaling, along with dopamine transport. These reflect a coherent theme of GPCR-mediated neurotransmitter signaling, despite a few outlier terms that may reflect annotation noise or broader regulatory connections. Overall, the proteins appear to function as regulators or components of synaptic signaling pathways mediated by GPCRs.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":29},{"id":"GO:0090075","count":29},{"id":"GO:0007194","count":29},{"id":"GO:0016998","count":29},{"id":"GO:0040015","count":29}]},{"hash":"365644423102811950","title":"ER-Golgi Transport & Golgi Organization","description":"Dominant GO terms point to the secretory pathway from the endoplasmic reticulum to the Golgi (ER-to-Golgi vesicle transport, ER exit, Golgi ribbon formation). This suggests the cluster comprises proteins regulating ER-Golgi traffic and Golgi architecture, with acrosome-related terms reflecting Golgi-derived secretory processes. Zinc-response and neuromuscular terms appear peripheral but may relate to broader signaling roles of secretory components. Overall, the theme is ER-Golgi trafficking and Golgi organization.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0071294","count":2},{"id":"GO:0050884","count":2},{"id":"GO:2000344","count":2},{"id":"GO:0090161","count":2}]},{"hash":"284610087637219210","title":"Rho GTPase\u2013driven cytoskeleton remodeling and motility","description":"This cluster is dominated by GO terms for small GTPase signaling, regulation of Rho signaling, and actin cytoskeleton organization, all pointing to coordinated actin remodeling and cell movement. Additional terms related to cell motility (neural/glial migration) and regulation of kinase activity support a theme of signaling pathways that drive cytoskeletal dynamics. Insulin/IGF signaling terms may reflect cross-talk but are secondary to the core motility-associated processes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0046626","count":4},{"id":"GO:0060313","count":3},{"id":"GO:0048009","count":3}]},{"hash":"1752208407586668078","title":"Innate immune signaling and phagocytosis","description":"Based on the top GO terms, the cluster is enriched for innate immune pathways: stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, and phagocytosis/recognition, as well as response to fungal origin and platelet activation. While a few development-related terms appear, the majority point to immune cell activation and pathogen recognition, justifying the label.","confidence":"High","size":28,"edges":376,"triangles":3224,"max_degree":27,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010572","count":28},{"id":"GO:0071226","count":28},{"id":"GO:0001502","count":27},{"id":"GO:0051873","count":27},{"id":"GO:0002223","count":27}]},{"hash":"169409405719040464","title":"Phagocytosis and antigen presentation in immune activation","description":"This cluster is enriched for phagocytosis-related activities (recognition and engulfment), innate immune response, complement activation, and antigen processing/presentation via MHC class Ib, together with B and T cell signaling, endocytosis regulation. The converging GO terms imply a functional module coordinating uptake of material and presentation to adaptive immunity, bridging innate and adaptive responses.","confidence":"High","size":28,"edges":159,"triangles":383,"max_degree":21,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":10},{"id":"GO:0050871","count":10},{"id":"GO:0045087","count":10},{"id":"GO:0006911","count":10},{"id":"GO:0050853","count":10}]},{"hash":"2297351960279957212","title":"Organ Development and Morphogenesis","description":"The top GO terms center on maturation and patterning across various organs and tissues: ureter maturation, blood vessel maturation, mitral valve formation, and Purkinje myocyte development all point to organogenesis, while lung branching morphogenesis and planar cell polarity involvement highlight tissue patterning. Calcium-dependent cell\u2013cell adhesion and intermicrovillar adhesion emphasize adhesion and structural organization during development. Some terms touch on neural transmission or organelle-related processes, but their coexistence with core morphogenesis terms suggests a broader developmental program shaping organ structure. Overall, the cluster seems best described as Organ Development and Morphogenesis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035799","count":28},{"id":"GO:0060489","count":28},{"id":"GO:0016339","count":28},{"id":"GO:0001955","count":28},{"id":"GO:1904938","count":28}]},{"hash":"1974131547878808879","title":"Ribosome Biogenesis and Translational Control","description":"This cluster is dominated by GO terms for translation, cytoplasmic translation, and ribosome biogenesis, with additional signals for regulation of initiation via eIF2 alpha phosphorylation and RNA silencing. This points to a core theme around ribosome production and the machinery of protein synthesis, with regulatory layers. A few terms related to development or behavior appear as noise, likely incidental annotations. ","confidence":"High","size":28,"edges":372,"triangles":3129,"max_degree":27,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":18},{"id":"GO:0009615","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0002181","count":5},{"id":"GO:0021610","count":5}]},{"hash":"1876512292619095195","title":"Integrin-Mediated Adhesion and Cell-Cell Signaling","description":"The Top Terms show a strong enrichment for cell adhesion and signaling related to extracellular matrix interactions (calcium-independent adhesion, integrin signaling, heterotypic cell-cell adhesion, extravasation) with additional context in development. While some terms pertain to specific developmental processes in plants or cartilage and dendrites, the central theme is adhesion\u2013driven signaling pathways that coordinate cell interactions and movement.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":16},{"id":"GO:0035987","count":15},{"id":"GO:0045123","count":15},{"id":"GO:0007161","count":15},{"id":"GO:0007229","count":15}]},{"hash":"1559941000829549295","title":"GABAergic signaling and sensory plasticity","description":"The cluster is dominated by GO terms related to GABA signaling, locomotory behavior, taste and pain perception, and long-term neuronal synaptic plasticity, suggesting a core theme of neuronal signaling and sensory processing. Some terms such as viral release and cell wall macromolecule catabolic process appear as peripheral associations but do not change the overall neural-focus signal.","confidence":"Medium","size":28,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":28},{"id":"GO:0007214","count":28},{"id":"GO:0001661","count":28},{"id":"GO:0051930","count":27},{"id":"GO:0000187","count":27}]},{"hash":"2149262073650841411","title":"Lipid signaling and reproductive development","description":"Top GO terms indicate prostaglandin biosynthesis and lipid metabolism (triglyceride, cholesterol) together with uterus development and maternal parturition, suggesting a theme where lipid-derived signaling molecules influence reproductive biology, with overlaps in vitamin D response and cell cycle regulation.","confidence":"Medium","size":28,"edges":265,"triangles":1318,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":17},{"id":"GO:0006641","count":16},{"id":"GO:0060065","count":16},{"id":"GO:0006707","count":15},{"id":"GO:0033280","count":14}]},{"hash":"1568268621314239215","title":"Auditory hair cell stereocilia and synapse organization","description":"These terms cluster around auditory/hair cell biology: stereocilium organization in auditory receptor cells, protein localization to synapse, receptor clustering, and sensory perception of sound. Although some terms are obsolete or broader, the dominant signal points to mechanisms underlying hair cell structure and synaptic function in hearing.","confidence":"High","size":28,"edges":46,"triangles":22,"max_degree":14,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0070433","count":24},{"id":"GO:0043113","count":23},{"id":"GO:2000821","count":23},{"id":"GO:1903760","count":22},{"id":"GO:0035418","count":22}]},{"hash":"223481907530547885","title":"Developmental Signaling and Chromatin Modification","description":"This cluster combines proteins linked to epigenetic regulation (histone acetylation, ubiquitination) with developmental and signaling processes (gastrulation, forebrain development, GPCR signaling, growth hormone response) and cytoskeletal dynamics (actin depolymerization, ciliogenesis). The common thread appears to be coordination of development through chromatin-level control and multiple signaling/cytoskeletal pathways, rather than a single isolated function.","confidence":"Medium","size":28,"edges":16,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043982","count":6},{"id":"GO:0043966","count":6},{"id":"GO:0043981","count":6},{"id":"GO:0000209","count":6},{"id":"GO:0060271","count":6}]},{"hash":"793040115544381538","title":"Filopodium dynamics and cell migration","description":"The proteins show strong enrichment for filopodium assembly and its regulation, along with small GTPase\u2013mediated signaling and cell migration. This points to actin cytoskeleton remodeling driving protrusion formation and motility as the core theme, with other terms like heart development and mitochondrial fission likely reflecting broader cellular remodeling contexts rather than a distinct separate function. ","confidence":"High","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0046847","count":14},{"id":"GO:0007264","count":14},{"id":"GO:1900026","count":14},{"id":"GO:0051932","count":13},{"id":"GO:0051489","count":13}]},{"hash":"371908723021864104","title":"T Cell Signaling and Cytokine Pathways","description":"The cluster is dominated by T cell\u2013related signaling terms, including T cell receptor signaling, Th2 cytokine production, IL-27\u2013mediated signaling, and STAT phosphorylation, indicating a core role in T cell\u2013mediated immune signaling. Developmental terms (kidney, nervous system) and other signaling pathways (ROBO, Smoothened) suggest possible pleiotropy or shared signaling components, but the strongest and most frequent terms point to immune receptor signaling and cytokine pathways.","confidence":"Medium","size":28,"edges":325,"triangles":2225,"max_degree":27,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0050852","count":14},{"id":"GO:0001822","count":14},{"id":"GO:0007224","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0035385","count":14}]},{"hash":"938017505157249290","title":"Cardiac GPCR Signaling and Contraction","description":"This cluster is defined by multiple GO terms pointing to G protein-coupled receptor signaling (acetylcholine and tachykinin receptor pathways) and regulation of heart contraction, including cardiac muscle contraction and its chemical regulation. The presence of apoptotic and anti-proliferative terms, alongside lipid metabolism and glycosphingolipid biosynthesis, suggests a broader context of cardiac cell signaling and remodeling, with membrane components and metabolic state possibly influencing GPCR-driven contraction. Overall, the dominant theme is GPCR-mediated signaling linked to cardiac function, with ancillary remodeling signals.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0048147","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0006688","count":3},{"id":"GO:0030259","count":3}]},{"hash":"1709255452754985769","title":"DNA Damage Response and Genome Maintenance","description":"The proteins cluster around stress responses (xenobiotic/toxic substances, X-ray) plus core genome-stability processes (DNA recombination, meiosis pairing, telomere maintenance via recombination, and DNA-templated transcription), all characteristic of a DNA damage response and genome maintenance module; a lone teichoic acid biosynthesis term may be noise. ","confidence":"Medium","size":28,"edges":39,"triangles":14,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0071375","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0019350","count":4}]},{"hash":"239466932915700574","title":"Embryogenesis and Growth with Gene Expression","description":"This cluster centers on developmental processes (in utero embryonic development, prostate gland development) and growth-related activities (cell cycle, cell division) and is accompanied by core gene expression machinery (mRNA processing, ribosome biogenesis). The common theme appears to be developmental growth coordinated by RNA processing and protein synthesis.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0000747","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1374955644290623938","title":"DNA repair and genome integration","description":"The cluster is dominated by GO terms for DNA recombination, double-strand break repair via nonhomologous end joining, and DNA integration, with a notable link to establishment of integrated proviral latency. While other terms like synaptic transmission and megakaryocyte development appear, the strongest signal centers on DNA repair and genome integration, suggesting proteins involved in DNA damage response and viral integration processes. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0006303","count":3},{"id":"GO:0097680","count":2},{"id":"GO:0000278","count":2}]},{"hash":"177635428942095586","title":"Developmental signaling and organogenesis","description":"The cluster is enriched for developmental processes (heart and forebrain development, multicellular growth) and signaling pathways (Roundabout pathway, ERK cascade, PI3K activity), suggesting roles in coordinating growth and organ formation. Some outlier terms (defense response, visual perception) may reflect broad gene functions or annotation noise, but the core theme centers on development and signaling. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0043552","count":7},{"id":"GO:0050830","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0035385","count":6}]},{"hash":"1869003542910762285","title":"Cytokine signaling and endosome trafficking","description":"The GO terms coalesce around cytokine production and signaling (IFN-\u03b3 and IL-2), broad cytokine-mediated signaling, and innate immune defense, coupled with endosome organization and GTPase-regulated trafficking. This suggests a functional cluster of proteins coordinating immune signaling through endosomal pathways and vesicle dynamics, with a component of pathogen defense (protozoan and LPS-related responses). Therefore, a concise label is Cytokine signaling and endosome trafficking.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032729","count":5},{"id":"GO:0007050","count":4},{"id":"GO:0042832","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0007032","count":3}]},{"hash":"1192386106781944238","title":"Neuroinflammation and neural development","description":"The top GO terms include inflammatory response and TLR4/LPS signaling alongside neural development processes (forebrain/spinal cord development, axonal fasciculation, axon regeneration), suggesting a neuroimmune theme with roles in neural growth/repair. One kidney morphogenesis term is present but does not dominate the cluster\u2019s function, so the label reflects the central inflammatory-neural connectivity.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007584","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0048681","count":3}]},{"hash":"2161959034305413192","title":"Actin cytoskeleton remodeling and cell adhesion","description":"The top terms cluster around actin dynamics (depolymerization, network formation, sarcomere organization) and cell\u2013matrix interactions (cell adhesion, Rho signaling). Angiogenesis and neuron projection development reflect cytoskeletal remodeling in morphogenesis, while mitotic spindle assembly points to broader cytoskeletal roles. Together, they suggest a cluster focused on actin-driven cytoskeletal reorganization and adhesion processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0030042","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0090307","count":4},{"id":"GO:1900042","count":4}]},{"hash":"17500353792815967","title":"Innate immune response and extracellular matrix remodeling","description":"This cluster is enriched in GO terms related to innate immunity and inflammation, including response to lipopolysaccharide, defense response to Gram-positive bacteria, and complement activation (classical and lectin pathways). The presence of blood coagulation and collagen catabolic process further supports a theme of immune defense coupled with tissue remodeling, potentially reflecting inflammatory and ECM turnover processes. Some development-related terms appear, but the dominant signal centers on immune defense and matrix remodeling, making this label representative.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0032496","count":9},{"id":"GO:0030901","count":9},{"id":"GO:0007596","count":8},{"id":"GO:0006958","count":8}]},{"hash":"642739534031092558","title":"Embryogenesis and Tissue Morphogenesis","description":"This cluster centers on developmental processes and morphogenesis: trophoblast giant cell differentiation, left-right pattern formation, EMT in endocardial cushion formation, cartilage morphogenesis, endocrine system development, pancreatic cell development, and cytoskeletal organization (actin bundles) and centrosome localization. Together these GO terms point to coordinated tissue differentiation and structural formation during embryogenesis and organogenesis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0003198","count":4}]},{"hash":"226820897507499014","title":"Embryonic development and transcriptional regulation","description":"This cluster centers on embryonic development and organogenesis, with terms like forebrain development, neural tube closure, in utero development, and multicellular organism development. It also highlights DNA-templated transcription and signaling pathways (Hippo, endothelial migration) that govern growth and tissue morphogenesis, plus a stress-induced apoptotic pathway component, aligning with a developmental/regulatory program. The presence of an immune defense term is peripheral to the main developmental theme, which supports a cohesive label focused on development and transcriptional control.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0030900","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0035329","count":3},{"id":"GO:0043536","count":3}]},{"hash":"1240356400769138567","title":"ECM Remodeling and Coagulation with Developmental Signaling","description":"The dominant terms point to extracellular matrix turnover (collagen catabolic process, extracellular matrix disassembly) and coagulation, with complementary activation indicating hemostatic involvement. The presence of angiogenesis and Wnt signaling alongside developmental terms (midbrain development, amelogenesis) suggests the cluster also reflects developmental signaling pathways that coordinate matrix remodeling and vascularization. Overall, a coherent theme is ECM remodeling coupled with coagulation and developmental signaling.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030574","count":10},{"id":"GO:0006958","count":10},{"id":"GO:0001867","count":10},{"id":"GO:0007596","count":9},{"id":"GO:0000122","count":9}]},{"hash":"204453683025458328","title":"Unknown","description":"The GO terms span meiotic processes, nuclear transport and transcription, mitochondrial dynamics, endothelial proliferation, immune defense, and apoptosis, with no single clear function tying the set together. This suggests a heterogeneous cluster rather than a cohesive biological role, so a concise functional label isn\u2019t evident.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051232","count":5},{"id":"GO:0051901","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0006607","count":4}]},{"hash":"544729146380573906","title":"Mechanosensation and mechanotransduction signaling","description":"This cluster shows enrichment for terms related to detecting and responding to mechanical stimuli (mechanosensation of pain, response to muscle stretch) and downstream signaling such as calcium release and cell migration, suggesting a shared mechanotransduction theme. Other terms like fat cell differentiation and telomere maintenance are present but less directly connected, so the core theme centers on mechanical cue sensing and signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045444","count":9},{"id":"GO:1904355","count":9},{"id":"GO:0051209","count":9},{"id":"GO:0006397","count":9},{"id":"GO:0035994","count":9}]},{"hash":"656970240500313273","title":"Innate Immune Signaling and TNF Regulation","description":"The top GO terms are dominated by innate immune response and positive regulation of TNF production, indicating an inflammation-focused cluster. While other terms touch on development and cell motility, the strongest and most representative theme is innate immune signaling and TNF-related regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032760","count":5},{"id":"GO:0010667","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007480","count":3},{"id":"GO:0090051","count":3}]},{"hash":"2176859731156514986","title":"Neural signaling and development","description":"The top GO terms cluster around neural activity and development: transmission of nerve impulses, auditory mechanosensation, trigeminal nerve organization, sympathetic neuron projection guidance, and neural crest migration, which together point to neural signaling and developmental processes. There are also cues about cell adhesion that can relate to neural connectivity, while a couple of terms (immune/complement and symbiont entry) appear less central to the core neural theme. Overall, the dominant pattern is neural signaling and neural development. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0019226","count":14},{"id":"GO:0050910","count":13},{"id":"GO:0007157","count":13},{"id":"GO:0006958","count":12},{"id":"GO:0046718","count":12}]},{"hash":"297518184033661254","title":"Paranode formation and axon development","description":"The top GO terms emphasize nervous system development, axon organization, and specifically paranodal junction assembly and localization to the paranode region of axons, along with axonal fasciculation and cell adhesion. This pattern points to coordinated processes of nerve fiber maturation and paranode-associated axon wiring, rather than unrelated cellular processes. Some terms are broader or obsolete, but the core signal is paranode-associated axon development.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":11},{"id":"GO:0030913","count":10},{"id":"GO:0000187","count":9},{"id":"GO:0014068","count":9},{"id":"GO:0007399","count":9}]},{"hash":"904612000875958638","title":"Embryonic development and morphogenesis","description":"This cluster centers on embryonic development, with terms tied to mesoderm formation, left-right patterning, palate and cartilage morphogenesis, placental/trophoblast differentiation, and EMT events in heart-related structures. The recurring themes of tissue morphogenesis and organogenesis support this label as representative of the cluster\u2019s function.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0003323","count":9},{"id":"GO:0060972","count":7},{"id":"GO:0060021","count":7},{"id":"GO:0060806","count":6}]},{"hash":"1205926763127338793","title":"Neurite outgrowth and neuronal polarity","description":"The top terms cluster around neuron projection development, axon extension, and microtubule bundle formation, pointing to a role in neurite outgrowth and establishing neuronal polarity. Additional terms like planar polarity and BMP signaling support a developmental and cytoskeletal organization theme relevant to neural development. Some unrelated terms (ion transport, Fc-epsilon signaling, skeletal development) are present but less representative of the core function. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0007613","count":3}]},{"hash":"1981335058820703410","title":"BMP/Activin signaling regulation in development","description":"The strongest signals are negative regulation of BMP signaling and negative regulation of activin receptor signaling, indicating modulators of TGF-beta/BMP pathways. This is complemented by terms related to development (CNS development, endothelial angiogenesis, germ-line stem cell division, myeloid differentiation) and transcriptional regulation, suggesting a set of proteins that modulate signaling to govern developmental and differentiation programs.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":3},{"id":"GO:0048147","count":3},{"id":"GO:0032926","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0043388","count":2}]},{"hash":"1728028403740137611","title":"Developmental Signaling Regulators","description":"The cluster is enriched for regulation of signaling pathways (positive regulation of GTPase activity, serine/threonine kinase activity, and autophosphorylation) and several developmental processes (neuron projection development, gastrulation, osteoblast differentiation), suggesting proteins that coordinate development via phosphorylation-driven signaling. An mRNA splicing term is present but does not dominate the theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0000398","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0071902","count":5},{"id":"GO:0007064","count":5}]},{"hash":"1313018177705757047","title":"Cell-Cell Adhesion and Neural Synapse Regulation","description":"The cluster is dominated by GO terms for cell-cell adhesion (heterophilic and homophilic) and regulation of synapse assembly, plus nervous system development and actin cytoskeleton regulation linked to adhesion, suggesting core functions in cell adhesion and neural synapse formation. Immune-regulatory terms and host cell interaction hints indicate broader roles in immune signaling and host interactions, but the adhesion/synapse theme appears central, justifying a neural-adhesion-centric label.","confidence":"Medium","size":27,"edges":245,"triangles":1052,"max_degree":25,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0043031","count":13},{"id":"GO:0002859","count":13},{"id":"GO:0043318","count":13},{"id":"GO:0086072","count":13}]},{"hash":"889721547809769474","title":"SCF-mediated mitotic protein degradation","description":"This cluster is dominated by ubiquitin-proteasome\u2013driven regulation of mitosis, highlighted by SCF-dependent proteasomal degradation, G2/M transition, mitotic progression, and chromosome segregation; other terms like DNA repair and development reflect broader coordination of cell cycle and genome maintenance.","confidence":"High","size":27,"edges":350,"triangles":2900,"max_degree":26,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031146","count":27},{"id":"GO:0000086","count":27},{"id":"GO:0007059","count":26},{"id":"GO:0016032","count":26},{"id":"GO:0070911","count":26}]},{"hash":"146070683353056058","title":"Neural development and synapse assembly","description":"This cluster is dominated by GO terms for nervous system development, synapse assembly, and glutamatergic synaptic transmission, with supporting roles for cell adhesion that facilitate neuron\u2013neuron contacts and connectivity. While other terms like ossification and blood vessel maturation appear, the strongest and most consistent signal is neural development and formation of synapses, including glutamatergic signaling. ","confidence":"High","size":27,"edges":39,"triangles":3,"max_degree":9,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007399","count":15},{"id":"GO:0043931","count":13},{"id":"GO:0007157","count":12},{"id":"GO:0007156","count":12},{"id":"GO:0051965","count":11}]},{"hash":"109991371183085177","title":"Broad Metabolic Biosynthesis and Signaling","description":"The top GO terms span multiple biosynthetic processes (fructose biosynthesis, lignin biosynthesis, fatty acid biosynthesis, pyruvate fermentation to ethanol) along with regulatory and response terms (extracellular negative regulation of signal transduction, response to lipopolysaccharide, positive regulation of blood pressure, respiratory system process). This suggests a cluster centered on broad metabolism with some signaling/regulatory aspects rather than a single cohesive pathway.","confidence":"Medium","size":27,"edges":309,"triangles":2090,"max_degree":26,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0046370","count":15},{"id":"GO:0000947","count":15},{"id":"GO:1900116","count":15},{"id":"GO:0009809","count":15},{"id":"GO:0043458","count":15}]},{"hash":"2093605955521050237","title":"Rho/Rac GTPase\u2013driven cytoskeletal signaling","description":"This cluster hubs on small GTPase signaling (Rho, Rac), microspike/cytoskeleton assembly, and related cell motility processes (neutrophil chemotaxis), with additional development-associated signals (Wnt, heart development) suggesting broader regulatory roles; the core theme is GTPase-regulated cytoskeletal dynamics driving movement and signaling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0030593","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0090263","count":5}]},{"hash":"1161485418025539053","title":"Mechanotransduction and cytoskeletal signaling in development","description":"The top GO terms center on cytoskeletal remodeling (actin filament branching, podosome assembly), GTPase regulation, cell polarity and shape, mechanosensitive responses, and receptor signaling (ephrin). Endocytosis and NF-kB modulation connect surface signaling to morphogenesis, with heart development highlighted, suggesting a cohesive role in development through mechanotransduction and cytoskeletal dynamics.","confidence":"Medium","size":27,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0006897","count":8},{"id":"GO:0071260","count":7},{"id":"GO:0043124","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1493583504348848646","title":"Neural plasticity and tissue development","description":"The cluster features neural plasticity terms (short-term memory, long-term synaptic potentiation) alongside broad tissue development processes (ossification, skeletal muscle and skin development, angiogenesis, kidney development), suggesting proteins involved in neural plasticity as well as multi-tissue development/remodeling. This broad, multi-tissue theme leads to a descriptive yet specific label.","confidence":"Medium","size":27,"edges":23,"triangles":5,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007614","count":8},{"id":"GO:0098735","count":8},{"id":"GO:0006469","count":8},{"id":"GO:0043588","count":8},{"id":"GO:0001525","count":8}]},{"hash":"397541335639368498","title":"Neural development and axon guidance via adhesion","description":"This cluster is dominated by neural-focused terms: heterophilic and homophilic cell-cell adhesion, nervous system development, protein localization to axon regions (paranode/juxtaparanode), and synapse assembly, plus neural crest\u2013related migration. While ossification and classical complement activation appear, the core signal ties to neural development and axon organization through cell adhesion.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":16},{"id":"GO:0043931","count":15},{"id":"GO:0006958","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0007156","count":13}]},{"hash":"632494113508097339","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":7},{"id":"GO:0007158","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0061146","count":5},{"id":"GO:0007605","count":5}]},{"hash":"1042802746914892313","title":"Neural Migration and Innate Immune Signaling","description":"The cluster centers on neural development processes (tangential migration to the olfactory bulb, branching morphogenesis of a nerve) and cytoskeletal remodeling (actin filament severing), with accompanying innate immune signaling (TLR1 pathway, detection of bacterial lipopeptide, response to antibiotic) and Wnt signalosome assembly. These terms together suggest proteins involved in neurodevelopment that are linked to cytoskeletal dynamics and immune sensing, justifying this label.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0051014","count":4},{"id":"GO:0019509","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0070340","count":3}]},{"hash":"1385169444026453166","title":"Ribosome biogenesis and RNA methylation","description":"The top GO terms cluster around ribosome assembly and rRNA processing (ribosome biogenesis; maturation of LSU-rRNA) and actively translated proteins (cytoplasmic translation), with several RNA modification/methylation processes (guanine-N7 methylation, tRNA ribose methylation, mRNA cap methylation). This points to a coherent theme of ribosome production and RNA modification rather than other unrelated processes. Some viral-related terms appear, but they are less central to the dominant signal. ","confidence":"High","size":27,"edges":16,"triangles":6,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0000463","count":3},{"id":"GO:1903595","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0097309","count":2}]},{"hash":"862894187943861858","title":"RNA processing and splicing regulation","description":"Many proteins in this cluster are annotated with RNA-related processes, including RNA splicing (GO:0008380), spliceosomal complex disassembly (GO:0000390), and mRNA capping (GO:0006370), plus helicase activity and nucleolar localization signals. The locomotory behavior term seems incidental. Overall, the dominant theme is RNA processing and splicing regulation.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":4},{"id":"GO:0097309","count":3},{"id":"GO:1904751","count":3},{"id":"GO:0051096","count":3},{"id":"GO:0006370","count":3}]},{"hash":"1481234382040660280","title":"Unknown","description":"The cluster shows a mix of GO terms spanning fertilization-related processes (sperm binding to zona pellucida, acrosome reaction, calcium ion import) and unrelated developmental and cellular terms (optic nerve morphogenesis, mRNA processing, sensory perception of sound). There isn\u2019t a single cohesive function or pathway that ties most proteins together, so a unified label isn\u2019t justifiable. Confidence: None","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0070493","count":3},{"id":"GO:0007339","count":3},{"id":"GO:0051489","count":3}]},{"hash":"1508712270746139419","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":9},{"id":"GO:0034316","count":9},{"id":"GO:0043547","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0000447","count":8}]},{"hash":"584608417996602334","title":"Signaling Pathways and Sensory Detection","description":"Proteins in this cluster are enriched for diverse signaling roles, including GPCR signaling, Wnt signaling, and regulation of GTPase activity, as well as calcium release. They also relate to responses to heat and temperature and mechanical stimuli (nociception), suggesting a theme of broad signaling and sensory/stress response rather than a single pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":8},{"id":"GO:0098907","count":8},{"id":"GO:0016055","count":8},{"id":"GO:0007049","count":7},{"id":"GO:0051209","count":7}]},{"hash":"763148331435130954","title":"Wnt signaling regulation and EMT-driven cell migration","description":"The top GO terms show strong signals for negative regulation of canonical Wnt signaling, epithelial-to-mesenchymal transition, cell migration, and related control of proliferation and apoptosis. These point to a cohesive theme where proteins modulate Wnt pathways to influence migration and cell fate, with additional notes on nuclear import and proton transport likely representing supplementary roles or annotation overlap.","confidence":"High","size":27,"edges":309,"triangles":2121,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090090","count":13},{"id":"GO:0016477","count":13},{"id":"GO:0008285","count":13},{"id":"GO:0043065","count":13},{"id":"GO:0086091","count":12}]},{"hash":"1097242024717386030","title":"Purine and Pyrimidine Transport","description":"The top GO terms cluster around importing nucleobases and related metabolites across membranes, including adenine, guanine, uracil, hypoxanthine, xanthine, and urate. A few broader transport terms are present, but the dominant signal is membrane transport of nucleobases, suggesting a set of proteins functioning as nucleobase transporters.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015747","count":2},{"id":"GO:0098721","count":2},{"id":"GO:0098710","count":2},{"id":"GO:0035344","count":2},{"id":"GO:0070904","count":2}]},{"hash":"581939411693586014","title":"Ribosome Biogenesis and Translation","description":"Most of the top GO terms cluster around protein synthesis and ribosome function (translation, translational initiation, ribosome biogenesis, tRNA modification), indicating the proteins are largely components of the translation machinery. Some terms like cell cycle and apoptotic process suggest links between growth regulation and translation, while a few specialized terms (ephrin signaling, placental and sensory development) appear less central and may be incidental annotations.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0006915","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0042254","count":5},{"id":"GO:0007605","count":5}]},{"hash":"709596236182642785","title":"Unknown","description":"The top GO terms are diverse, spanning virus defense regulation, carbohydrate and glycosphingolipid metabolism, RNA processing and gene expression control, cellular responses to glucose starvation and IL-1 signaling, ubiquitin-dependent protein degradation, and cell wall organization. There is no clear, single biological theme unifying these terms, and the cluster lacks connected edges, making a precise functional label unjustified. ","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0002230","count":4},{"id":"GO:0005975","count":3},{"id":"GO:1903799","count":3},{"id":"GO:0042149","count":3},{"id":"GO:0006688","count":3}]},{"hash":"1515528619164588671","title":"Neuronal dendrite morphogenesis and RNA metabolism","description":"The cluster shows strong signals for neuronal structure changes (dendrite morphogenesis, regulation of axon extension) along with extensive RNA processing and translation-related activities (mRNA processing/splicing, translation initiation/reinitiation, tRNA methylation). This combination suggests proteins coordinating RNA metabolism with dendrite development in neurons, justifying a label focused on both neuronal morphogenesis and RNA biology.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0048813","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0030517","count":3}]},{"hash":"722991714387544430","title":"Neural development and sensory perception","description":"These proteins show enrichment for neural-related terms, notably detection of mechanical and temperature stimuli (pain and thermoception) and cerebellar granule cell differentiation, pointing to neural development and sensory signaling as the main theme. While other terms span general processes (cell growth, transcription regulation, angiogenesis) and may reflect broader roles, the dominant neural signals support naming this cluster around neural development and sensory perception.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":14},{"id":"GO:0035544","count":14},{"id":"GO:0050960","count":14},{"id":"GO:0021707","count":14},{"id":"GO:0016049","count":14}]},{"hash":"736368500573807501","title":"Neural development and organogenesis signaling","description":"The cluster is enriched for nervous system development and neurogenesis terms, with additional organogenesis signals (kidney development, angiogenesis) and related signaling pathways (PI3K-AKT, STAT phosphorylation), suggesting a cohesive theme of developmental signaling governing neural differentiation and organ formation.","confidence":"Medium","size":27,"edges":285,"triangles":1621,"max_degree":26,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0042517","count":10},{"id":"GO:0060068","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0008284","count":10},{"id":"GO:0006915","count":10}]},{"hash":"359625864218646152","title":"Cytoskeleton regulation and cell\u2013cell adhesion","description":"The cluster is dominated by GO terms tied to cytoskeletal dynamics and cell\u2013cell interactions: actin cytoskeleton organization, pseudopodium assembly, calcium-dependent cell\u2013cell adhesion, and regulation of actin cytoskeleton by cell\u2013cell adhesion, plus localization to cortical microtubule cytoskeleton. These point to coordinated control of the cytoskeleton and adhesion mechanisms, which drive cell shape changes, movement, and tissue organization. Some terms about nuclear import and proton transport appear less connected, but overall the strongest signal is cytoskeletal regulation and adhesion.","confidence":"Medium","size":27,"edges":22,"triangles":4,"max_degree":11,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":12},{"id":"GO:0006607","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0086091","count":10},{"id":"GO:0031274","count":10}]},{"hash":"1008314762536489212","title":"Unknown","description":"The Top Terms span innate immune signaling (MyD88-dependent TLR4 pathway), transcription regulation, muscle development, DNA repair, Golgi organization, exocytosis, and cell division. There is no single coherent biological process linking these terms, suggesting a heterogeneous set rather than a distinct, shared function.  ","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035660","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0007527","count":3},{"id":"GO:0000724","count":2},{"id":"GO:1990414","count":2}]},{"hash":"1917602032959122339","title":"Ubiquitination-Driven Degradation and NF-kappaB Signaling","description":"This cluster centers on ubiquitin tagging and proteasomal degradation (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, histone ubiquitination, K6-linked ubiquitination) and includes signaling and apoptotic regulation (NF-kappaB activation, TNF signaling, regulation of apoptotic process), suggesting a coherent module of ubiquitin-mediated regulation of degradation and NF-kappaB\u2013related signaling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0051865","count":9},{"id":"GO:0016567","count":9},{"id":"GO:1903265","count":8},{"id":"GO:0036205","count":8}]},{"hash":"2289987761945291104","title":"Eye and craniofacial development","description":"This cluster is dominated by GO terms related to the visual system (visual perception, lens fiber differentiation, camera-type eye development) and craniofacial morphogenesis (midbrain development, inner ear development, roof of the mouth, embryonic cranial skeleton). The convergence on eye-related development alongside broader craniofacial/neuronal development suggests a shared function in ocular and cranial morphogenesis.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0007601","count":7},{"id":"GO:0070306","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0048839","count":5}]},{"hash":"1688342488168924914","title":"Rho GTPase-actin cytoskeleton regulation","description":"The top GO terms cluster around regulation of Rho signaling, regulation of GTPase activity, and actin cortical patch assembly, pointing to coordinated control of cytoskeleton remodeling by Rho-family signaling. While there are broader signaling notes (kinase regulation, Fc signaling, transcription), the dominant theme is Rho/GTPase-driven actin dynamics relevant to signaling and development contexts such as synaptic plasticity and heart development.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0060368","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0006469","count":2}]},{"hash":"362251211474640162","title":"Mitochondrial Metabolite Transport and Insulin Signaling","description":"The GO terms point to transport of cofactors and metabolites (glycine, NAD, thiamine pyrophosphate, citrate, thiosulfate) across membranes, plus mitochondrial dynamics (fission) and energy/insulin-related signaling (adaptive thermogenesis, insulin/IGF stimulus responses). This suggests a cohesive theme of mitochondrial metabolite transport intertwined with insulin-mediated energy regulation.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036233","count":18},{"id":"GO:0090149","count":18},{"id":"GO:0035352","count":18},{"id":"GO:0030974","count":18},{"id":"GO:1990845","count":18}]},{"hash":"497153577162529474","title":"Dopaminergic GPCR signaling regulation","description":"This cluster is dominated by GO terms relating to negative regulation of dopamine receptor signaling and adenylate cyclase activity, plus dopamine transport and GPCR-mediated pathways, suggesting a cohesive theme around dopaminergic signaling modulation. Additional terms touch on related neuronal processes (e.g., GABAergic interneuron migration) and acetylcholine receptor\u2013linked AC inhibition, though a few annotations (like cell wall catabolism or thymocyte differentiation) appear less connected and may reflect broader or species-specific roles. Overall, the core function inferred is regulation of dopamine signaling via GPCR/AC pathways.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":27},{"id":"GO:0090075","count":27},{"id":"GO:0007194","count":27},{"id":"GO:0016998","count":27},{"id":"GO:0040015","count":27}]},{"hash":"2194746776927084955","title":"Actin Dynamics in Neural and Immune Signaling","description":"The cluster centers on actin cytoskeleton remodeling (actin filament organization, lamellipodium assembly) and neuronal development cues (dendritic spine morphogenesis, neuron development), with additional immune signaling terms (adaptive/innate responses, B cell receptor signaling, IL-2 production). This suggests proteins that facilitate cytoskeletal changes supporting both neural structure/motility and immune cell activation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007015","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0060997","count":3},{"id":"GO:0007050","count":2},{"id":"GO:0014902","count":2}]},{"hash":"2214329107505389041","title":"Developmental transcription and morphogenesis","description":"The cluster\u2019s top GO terms center on DNA-templated transcription and multicellular development, with supporting signals in cell growth, cell-matrix adhesion, and budding growth, pointing to developmental regulation and morphogenesis. Some terms (e.g., transport, cocaine response) appear peripheral but do not override the core theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007275","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0001300","count":2},{"id":"GO:0016049","count":2}]},{"hash":"206047855308561958","title":"Placental and Embryonic Development","description":"This cluster is dominated by GO terms tied to embryogenesis and reproductive tissue development, including placental formation, trophoblast differentiation, mesoderm development, and left-right patterning, with ancillary terms on palate/craniofacial development and EMT in heart structures. The recurring theme is early developmental programs, especially placenta-related processes, suggesting the proteins function in embryonic tissue patterning and differentiation.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060806","count":20},{"id":"GO:0035270","count":20},{"id":"GO:0060536","count":20},{"id":"GO:0060707","count":20},{"id":"GO:0060972","count":20}]},{"hash":"937646351613326862","title":"Ubiquitin and Sumoylation Regulators","description":"The top GO terms are dominated by ubiquitin-related processes (autoubiquitination, deubiquitination, ERAD, and sumoylation) and associated signaling, suggesting a cluster of proteins involved in regulating protein modification and degradation. Some terms like miRNA processing and ABA biosynthesis appear, but the strongest cohesive theme is ubiquitin/SUMO pathway regulation.","confidence":"Medium","size":26,"edges":217,"triangles":842,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":14},{"id":"GO:0030433","count":14},{"id":"GO:0051865","count":14},{"id":"GO:0016579","count":11},{"id":"GO:0016925","count":11}]},{"hash":"862586941548833947","title":"Unknown","description":"The top GO terms span diverse, non-overlapping processes (drug responses, several lipid and small-molecule biosyntheses, development) across different organisms, so there\u2019s no single cohesive function tying all 26 proteins together; this looks like annotation noise or a highly heterogeneous cluster.","confidence":"","size":26,"edges":286,"triangles":1785,"max_degree":25,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":24},{"id":"GO:0031427","count":17},{"id":"GO:0030324","count":17},{"id":"GO:0009710","count":17},{"id":"GO:0042619","count":17}]},{"hash":"1514759905865832965","title":"Cardiac development and epithelial polarity regulators","description":"The top GO terms show strong signals for heart development and cardiac muscle contraction, pointing to cardiac-related functions. At the same time, multiple terms relate to epithelial cell polarity, tight junctions, centrosome localization, and cytoskeletal organization (microvillus assembly, Rho signaling). Together these suggest a cluster of proteins involved in cardiac morphogenesis alongside epithelial polarity and cytoskeletal dynamics. While there are hints of broader regulation (NF-kappaB signaling, mitotic cell cycle), the core themes appear to be cardiac development and epithelial polarity/cytoskeleton regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051835","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0030033","count":5},{"id":"GO:0051660","count":5}]},{"hash":"1699096923605133644","title":"Visual and Dopaminergic Neural Signaling","description":"The top GO terms include visual learning and visual perception, dopaminergic synaptic transmission, cocaine-related behavioral response, and ERK signaling, all pointing to neural signaling and synaptic plasticity in visual and reward pathways. Regulation of GTPase activity supports cytoskeletal changes underlying plasticity. Some terms are from other contexts, but the dominant theme is neural communication and plasticity.","confidence":"High","size":26,"edges":299,"triangles":2032,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":18},{"id":"GO:0043547","count":18},{"id":"GO:0007601","count":18},{"id":"GO:0070374","count":18},{"id":"GO:0048148","count":18}]},{"hash":"1050938580988694889","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":247,"triangles":1365,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":25},{"id":"GO:0000278","count":25},{"id":"GO:0007117","count":22},{"id":"GO:0060271","count":22},{"id":"GO:0050709","count":22}]},{"hash":"1209463813572950836","title":"Glutamatergic Synaptic Transmission and Ion Transport","description":"The top GO terms center on glutamatergic synaptic transmission, excitatory postsynaptic potentials, and sodium/potassium ion transport, which together indicate neuronal signaling and ion-channel activity. A few terms related to defense responses or cell wall metabolism appear as noise, but the dominant terms strongly point to a neural signaling function, justifying the label.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0000187","count":11},{"id":"GO:0042742","count":11},{"id":"GO:0007626","count":11},{"id":"GO:0035725","count":10},{"id":"GO:0071805","count":10}]},{"hash":"698576472240230819","title":"Insulin signaling and metabolic regulation","description":"The top GO terms cluster around insulin signaling (GO:0008286), IGF signaling (GO:0048009), regulation of glycogen biosynthesis, and fatty acid metabolism, suggesting a group of proteins involved in insulin-driven metabolic control. Some terms touch vascular or GPCR signaling, but the dominant theme is insulin-mediated metabolic regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0045907","count":21},{"id":"GO:0007213","count":21},{"id":"GO:0035924","count":21},{"id":"GO:2001275","count":20},{"id":"GO:0048009","count":19}]},{"hash":"130251656045585630","title":"Glycolysis and carbohydrate metabolism","description":"The cluster\u2019s prominent GO terms revolve around sugar and carbohydrate processing, especially glycolysis via fructose-6-phosphate, carbohydrate phosphorylation, and responses to sugars like sucrose and fructose, plus related sugar catabolic pathways (including sulfoquinovose and ribose catabolism). While there is occasional mention of broader processes (cell division, AMP salvage), the dominant theme is carbohydrate metabolism and energy generation through glycolytic/sugar-processing pathways.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0009744","count":4},{"id":"GO:0010264","count":4},{"id":"GO:0009750","count":4}]},{"hash":"2020872343134936526","title":"GTPase Signaling and Proliferation Regulation","description":"The top GO terms cluster around regulation and activation of heterotrimeric GTPases (positive regulation of GTPase activity, protein heterotrimerization), pointing to G-protein\u2013mediated signal transduction. Additional terms touch on signaling-related processes (TGF-beta response, hypoxia response, nutrient response) and developmental/proliferative outcomes (mitotic cell cycle, neural tube closure, positive regulation of cell proliferation), suggesting a cohesive role in signaling pathways that govern growth, development, and cell cycle control.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0070208","count":9},{"id":"GO:0071456","count":9},{"id":"GO:0008284","count":9},{"id":"GO:0051028","count":8}]},{"hash":"2157128361262308139","title":"Neural development and synaptic regulation","description":"This cluster centers on brain development, cochlea morphogenesis, regulation of synaptic vesicle exocytosis, and synapse structural plasticity, indicating a core theme of neural development and synaptic maturation; a few mitotic terms are present but do not override the neural-synaptic focus.","confidence":"High","size":26,"edges":55,"triangles":10,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":12},{"id":"GO:0035264","count":11},{"id":"GO:2000300","count":10},{"id":"GO:0051301","count":10},{"id":"GO:0051835","count":10}]},{"hash":"1901944351296483878","title":"Actin cytoskeleton remodeling and endocytosis","description":"The proteins in this cluster are strongly linked to actin dynamics and vesicle trafficking, highlighted by Arp2/3 complex\u2013mediated actin nucleation, actin cortical patch assembly, and regulation of endocytosis. While a few tissue- or development-related terms appear, the dominant theme is actin cytoskeleton remodeling and endocytic processes.","confidence":"High","size":26,"edges":324,"triangles":2576,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:1904623","count":24},{"id":"GO:0032508","count":24},{"id":"GO:0030100","count":24},{"id":"GO:0000147","count":24},{"id":"GO:0034314","count":24}]},{"hash":"841808019277091269","title":"Ribosome Biogenesis and Chromatin Assembly","description":"This cluster shows a strong signal for RNA processing and nucleolar functions, with terms like ribosomal large subunit biogenesis, 5.8S rRNA maturation, mRNA transport, and CENP-A chromatin assembly, pointing to roles in ribosome production and chromosome maintenance. Brain development and ER-Golgi vesicle transport terms appear as peripheral associations, suggesting multifunctional proteins or broader cellular contexts rather than a single unified pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0006888","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0051568","count":4},{"id":"GO:0006890","count":3}]},{"hash":"1878974258774102614","title":"Spliceosome-Mediated RNA Splicing and Export","description":"Based on numerous spliceosome-related terms (mRNA splicing, regulation of splicing) along with mRNA export and stress-related mRNA stability, the cluster appears to consist of proteins involved in RNA maturation and nuclear export pathways, particularly spliceosomal processing of mRNA.","confidence":"High","size":26,"edges":316,"triangles":2401,"max_degree":25,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":13},{"id":"GO:1901407","count":9},{"id":"GO:0008033","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0031047","count":8}]},{"hash":"468272382067326888","title":"Diverse solute transmembrane transport","description":"The cluster is dominated by GO terms for transporting various substrates across membranes, including xenobiotics, vitamins, ions (potassium), nitrite, and dehydroascorbic acid. This points to a set of membrane transport proteins with broad substrate specificity rather than a single substrate type, making \u201cdiverse solute transmembrane transport\u201d an intuitive, specific label. Some outlier terms (e.g., certain metabolic or regulatory processes) are likely noise relative to the core transport theme.","confidence":"Medium","size":26,"edges":47,"triangles":16,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":25},{"id":"GO:0035461","count":25},{"id":"GO:0042891","count":23},{"id":"GO:0071805","count":20},{"id":"GO:0042908","count":20}]},{"hash":"956660337686443505","title":"Retinoid metabolism and signaling","description":"The cluster is dominated by retinal and retinol metabolic processes and regulation of retinoic acid receptor signaling, pointing to a core role in vitamin A metabolism and signaling. Additional terms (prostaglandin and bile acid biosynthesis, sugar alcohol biosynthesis) suggest broader lipid and carbohydrate metabolism, as well as oxidative stress responses, but the retinoid theme is strongest.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":26},{"id":"GO:0042572","count":26},{"id":"GO:0001516","count":18},{"id":"GO:0060135","count":18},{"id":"GO:0003091","count":18}]},{"hash":"620201712531422461","title":"Ubiquitin-Driven Immune Cell Differentiation","description":"The cluster is enriched for ubiquitin-related processes (ubiquitin-dependent protein catabolic process and protein ubiquitination) alongside immune-related development terms (innate immune response, germinal center formation, positive regulation of dendritic cell and pro-T cell differentiation, and IgE isotype regulation). This points to a theme of ubiquitin-mediated regulation of immune cell differentiation and signaling, with a few outlier terms suggesting broader developmental roles in other tissues. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0016567","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0002467","count":8},{"id":"GO:2001200","count":8}]},{"hash":"264057423400815658","title":"Ciliary-Centrosomal Signaling in Development and Neural Function","description":"The terms center on cilium assembly and centrosome localization, with calcium signaling and neural-related processes (synaptic depression, locomotory behavior) within a developmental context, pointing to a theme of ciliary-centrosomal signaling shaping development and neural function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035641","count":3},{"id":"GO:0051660","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0060271","count":2}]},{"hash":"1233952946218779287","title":"Embryonic heart, bone, and CNS development","description":"This cluster is enriched for GO terms spanning cardiac and skeletal development (heart development, bone development, osteoblast fate, skeletal system development, craniofacial roof of mouth development) and CNS development, plus a common thread of morphogenesis and tissue patterning (e.g., epithelial to mesenchymal transition in heart formation) with regulation by Rho signaling. The diversity of related yet distinct developmental processes suggests a general role in embryonic morphogenesis and tissue specification rather than a single, narrow function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0060291","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0002051","count":4},{"id":"GO:0060348","count":4}]},{"hash":"2007778937793290852","title":"RNA processing and translation initiation","description":"This cluster is enriched for proteins involved in RNA maturation and translation initiation, including translation initiation and preinitiation complex formation, along with mRNA splicing, modification, and stabilization. This suggests a cohesive role in RNA metabolism and protein synthesis initiation, despite no direct interaction edges in the network.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":14},{"id":"GO:0001731","count":14},{"id":"GO:0006378","count":13},{"id":"GO:0045292","count":12},{"id":"GO:1905663","count":11}]},{"hash":"75920718913298221","title":"Actin Cytoskeleton Dynamics in Neuronal and Epithelial Contexts","description":"The top GO terms cluster around actin cytoskeleton organization and polymerization, transcytosis, and tight junction assembly, which reflect actin-driven remodeling and cell polarity across cell types. Neuronal-related terms (sensory perception of sound, long-term synaptic depression) and development-related terms (atrial septum morphogenesis) suggest this remodeling influences both neural and epithelial/trafficking contexts. The shared theme is dynamic actin-based regulation of trafficking, junctions, and polarity across diverse tissues, justifying a unified label.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045056","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0007605","count":3},{"id":"GO:2000251","count":2},{"id":"GO:0030041","count":2}]},{"hash":"401117137474108520","title":"Pain and Temperature GPCR-CAMP Signaling","description":"The terms cluster around neural pain perception and temperature response, with prostaglandin signaling and GPCR-adenylate cyclase activation (GO:0019233, GO:0002024, GO:0071502, GO:0071380, GO:0010579, GO:0007190). The co-occurrence of energy/metabolism and cardiovascular terms (electron transport chain, heart development, blood pressure) suggests a broader theme of thermoregulatory/sensory signaling linked to metabolic and cardiovascular readiness.","confidence":"Medium","size":26,"edges":47,"triangles":2,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":19},{"id":"GO:0002024","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0071380","count":17},{"id":"GO:0007190","count":17}]},{"hash":"1999017057386485445","title":"Rho/Rac GTPase Signaling in Development","description":"This cluster centers on regulation of Rho and Rac GTPase pathways (GO:0035023, GO:0035021) and positive regulation of GTPase activity, pointing to roles in cytoskeletal dynamics and signal transduction. It also includes heart development, spermatogenesis, multicellular organism growth, and DNA-templated transcription and replication, suggesting involvement in growth, differentiation, and genome regulation. The defense response to Gram-positive bacterium is less connected but may reflect broader signaling cross-talk; overall the dominant pattern is GTPase-mediated signaling linked to developmental processes.","confidence":"Medium","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0035264","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007507","count":3}]},{"hash":"291264157951184728","title":"Mitochondrial Translation and Energy Metabolism","description":"The cluster is enriched in GO terms for mitochondrial translation, rRNA maturation, cristae formation, proton transport, and ATP synthesis, pointing to a cohesive module of mitochondrial gene expression and respiration; some terms like photosynthesis may reflect plastid-like components, but the dominant signal is organellar protein synthesis and energy production.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":3},{"id":"GO:0032543","count":2},{"id":"GO:0042407","count":2},{"id":"GO:0099132","count":2},{"id":"GO:0015986","count":2}]},{"hash":"719788388567438342","title":"GPCR-cAMP Signaling in Heart and Brain","description":"The cluster centers on GPCR-driven signaling and adenylate cyclase activation (GO:0010579, GO:0007190), with strong cardiovascular ties (blood pressure regulation, heart development) and neural processes (dopaminergic synaptic transmission, pain, visual learning) as well as prostaglandin response. An accompanying electron transport chain term suggests linked energy metabolism, supporting a broad GPCR-cAMP\u2013based coordination of heart and brain signaling. ","confidence":"High","size":26,"edges":36,"triangles":1,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":20},{"id":"GO:0007190","count":20},{"id":"GO:0022900","count":20},{"id":"GO:0010579","count":20},{"id":"GO:0071380","count":19}]},{"hash":"21043632547375450","title":"Mitotic cell cycle regulation and transcription","description":"This cluster is dominated by cell-cycle related terms (G1/S and G2/M transitions, spindle pole separation, chromosome condensation) and DNA-templated transcription, indicating proteins that coordinate transcription with mitotic progression. Additional terms around proliferative signaling (insulin receptor pathway regulation, mammary gland proliferation) fit the broader context of cell division in proliferative tissues but do not alter the core theme.","confidence":"High","size":26,"edges":115,"triangles":186,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":17},{"id":"GO:0032026","count":17},{"id":"GO:0046626","count":15},{"id":"GO:0000082","count":15},{"id":"GO:0000320","count":15}]},{"hash":"350063422893982870","title":"N-linked Glycosylation and Glycan Biosynthesis","description":"The top GO terms cluster around N-linked glycosylation, N-glycan processing, oligosaccharide metabolism, and ganglioside biosynthesis, with an ER-to-Golgi transport connection, suggesting a cohesive theme of glycoprotein/glycolipid biosynthesis and trafficking. While some terms touch on plant pollen development or olfactory structures, these likely reflect broader roles of glycosylation in development rather than a single pathway. Overall, the dominant signal points to glycan-based biosynthesis and processing.","confidence":"High","size":26,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0071699","count":3},{"id":"GO:0018279","count":3},{"id":"GO:0006054","count":3},{"id":"GO:0006491","count":3}]},{"hash":"812147605105985588","title":"Neuronal development and sensory function","description":"The cluster is dominated by GO terms related to nervous system development and sensory processes (axonogenesis, schwann cell development, visual perception, excitatory synaptic activity). While there are some terms touching on muscle activity, cell cycle, and proteasome regulation, the strongest signal points to neural development and sensory signaling, suggesting proteins involved in neuron formation and sensory pathways.","confidence":"Medium","size":26,"edges":33,"triangles":0,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0014850","count":24},{"id":"GO:0007520","count":24},{"id":"GO:0000086","count":24},{"id":"GO:0032435","count":24},{"id":"GO:0007409","count":24}]},{"hash":"1663591834605922548","title":"Ubiquitin-Dependent Protein Degradation","description":"This cluster is dominated by GO terms for ubiquitin-mediated proteolysis, including ubiquitin-dependent protein catabolic process, protein polyubiquitination, SCF-dependent proteasomal degradation, and autoubiquitination. The circadian rhythm regulation term suggests clock-related turnover, which often involves ubiquitin-proteasome processes, while sarcomere organization hints at proteostasis in muscle. Overall, the common theme is ubiquitin-driven protein degradation and turnover.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0042752","count":12},{"id":"GO:0000209","count":9},{"id":"GO:0045214","count":8},{"id":"GO:0031571","count":7}]},{"hash":"346761195412864908","title":"Synaptic function and neuronal development","description":"The cluster is dominated by terms for synaptic potentiation, vesicle exocytosis, and synapse assembly, with additional links to cytoskeletal Rho/GTPase signaling and neuronal migration, suggesting a collective role in synaptic maturation and signaling during neural development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060291","count":6},{"id":"GO:2000300","count":5},{"id":"GO:0007416","count":5},{"id":"GO:0043087","count":5},{"id":"GO:0016525","count":5}]},{"hash":"20792772496847444","title":"Lipid catabolism and detoxification","description":"The top GO terms cluster around lipid breakdown: triglyceride, monoacylglycerol, and phosphatidylserine catabolic processes, plus endocannabinoid signaling regulation, all pointing to lipid-based metabolism and signaling. Detoxicative and stress-response terms (cellular oxidant detoxification, response to toxic substance) reinforce a theme of handling lipid-derived molecules and potential toxins. While there are some biosynthetic terms (biotin, antibiotic, PHB, chlorophyll) that are more diverse, they do not override the dominant lipid catabolic signal. Overall, a cohesive label is lipid breakdown and detox pathways.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":9},{"id":"GO:0006660","count":9},{"id":"GO:2000124","count":9},{"id":"GO:0052651","count":9},{"id":"GO:0015996","count":7}]},{"hash":"804015378841293858","title":"Ras/Rho Signaling with Synaptic and Trafficking Roles","description":"The cluster is enriched for terms involving regulation of Ras and Rho GTPase signaling, which often drive cytoskeletal dynamics and membrane trafficking. It also includes synaptic-related processes (synapse assembly, long-term potentiation) and membrane signaling pathways (IP3 biosynthesis, phospholipid catabolism) as well as vesicle-related functions (intracellular transport) and secretory events (acrosome reaction), suggesting a common theme of GTPase-regulated signaling coordinating signaling, trafficking, and exocytosis across cell types.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0046580","count":11},{"id":"GO:0035023","count":11},{"id":"GO:0009395","count":10},{"id":"GO:0060291","count":10},{"id":"GO:0002316","count":10}]},{"hash":"1818021164987553535","title":"Neural development and MAPK signaling","description":"The top GO terms converge on nervous system development (including hippocampus) and positive regulation of ERK and JNK cascades, indicating a neural development cluster governed by MAPK signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0051291","count":5}]},{"hash":"1184379470287752036","title":"Cytoskeletal Dynamics, Polarity, and Junctions in Development","description":"These terms converge on cytoskeletal remodeling and cell architecture: microtubule dynamics, GTPase regulation, podosome and tight junction assembly, membrane tubulation, and polarity maintenance, with links to neuron and bone development and innate immune responses. The cluster seems to group proteins involved in controlling cell shape, adhesion, and development through cytoskeletal and membrane remodeling.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007026","count":4},{"id":"GO:0048666","count":4},{"id":"GO:0045087","count":4},{"id":"GO:2000769","count":4},{"id":"GO:0051044","count":4}]},{"hash":"860678227249898924","title":"Ubiquitin-Mediated Proteolysis in Innate Immunity","description":"This cluster is dominated by ubiquitin-dependent protein catabolic processes (including SCF-proteasomal pathways and ERAD), along with innate immune defense and defense against viruses. The presence of related terms such as K6-linked ubiquitination and NF-\u03baB activity, plus links to circadian rhythm and vitamin D response, supports a cohesive role for ubiquitin-driven proteolysis in antiviral immunity and its regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0045087","count":13},{"id":"GO:0051607","count":13},{"id":"GO:0030433","count":9},{"id":"GO:0031146","count":9}]},{"hash":"389925668887221811","title":"Immune cell differentiation signaling","description":"The cluster is enriched for terms tied to immune development, including positive regulation of dendritic cell differentiation, positive regulation of pro-T cell differentiation, and germinal center formation, alongside intracellular signal transduction and endocytosis-related processes. While there are some cell cycle/morphogenesis terms present, the immune-related functions dominate, suggesting these proteins participate in immune cell differentiation and signaling pathways. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":7},{"id":"GO:0048549","count":6},{"id":"GO:0050966","count":6},{"id":"GO:0035556","count":6},{"id":"GO:0002467","count":5}]},{"hash":"1921001845348905816","title":"Core translation and genome maintenance","description":"This cluster is driven by GO terms for translation, DNA replication, and DNA repair, pointing to essential housekeeping processes that support protein synthesis and genome integrity. Additional terms related to autophagy regulation and mitochondrial morphogenesis fit within cellular maintenance and quality control. Some terms like angiogenesis and cocaine response are outliers, but the dominant theme centers on core cellular maintenance functions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":3},{"id":"GO:0015966","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0032435","count":2},{"id":"GO:0001300","count":2}]},{"hash":"1846667809559514933","title":"Angiogenesis and extracellular matrix remodeling","description":"The terms cluster around blood vessel formation and remodeling: collagen fibril organization and fibrinolysis point to ECM dynamics, while angiogenesis and endothelial cell migration indicate vascular development. Negative regulation of endothelial/platelet apoptosis and other signaling regulators suggest endothelial homeostasis within vessels. Together they describe angiogenesis coupled with ECM remodeling in the vasculature.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein maturation","top_go_terms":[{"id":"GO:0030199","count":6},{"id":"GO:0045766","count":5},{"id":"GO:1902042","count":5},{"id":"GO:0042730","count":4},{"id":"GO:2000352","count":4}]},{"hash":"1515940374203303297","title":"RNA Pol II Transcription Regulators","description":"The top terms are dominated by both negative and positive regulation of transcription by RNA polymerase II, pointing to a core function in transcriptional control. Other terms (complement activation, development, immune response) suggest some annotation noise or multifunctionality, and the lack of observed edges reduces cohesion, so this label is a best-fit with Medium confidence. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0006958","count":9},{"id":"GO:0001867","count":9},{"id":"GO:0030901","count":8},{"id":"GO:0055123","count":7}]},{"hash":"1096743059356097318","title":"Mitochondrial transport and energy metabolism","description":"Top GO terms are dominated by mitochondrial processes: membrane fission, transmembrane transport of citrate, magnesium, and nucleotides, plus phosphate ions, and energy-related pathways like adaptive thermogenesis and fatty acid response. This points to proteins involved in mitochondrial metabolism and ion/metabolite transport rather than a single cytosolic pathway.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1990314","count":8},{"id":"GO:0007565","count":8},{"id":"GO:0070542","count":8},{"id":"GO:0090149","count":7},{"id":"GO:0036233","count":7}]},{"hash":"1121309140929737331","title":"Mechanotransduction and Rho-PI3K Signaling","description":"The top GO terms cluster around signaling pathways (PI3K-Akt), Rho and GTPase activation, and response to mechanical stimuli, suggesting a core theme of mechanotransduction and cytoskeletal regulation. Other terms reflect broader signaling contexts (platelet activation, fat differentiation, vitamin D response) but still fit within an overall signaling/cell-fate framework. Confidence: Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:2001241","count":6},{"id":"GO:0071625","count":6},{"id":"GO:0071260","count":5},{"id":"GO:0010572","count":5},{"id":"GO:0043491","count":5}]},{"hash":"1623422292633433293","title":"Sperm flagellum assembly and ciliary tubulin modifications","description":"The terms cluster around sperm axoneme assembly, flagellated sperm motility, and cilium movement, with emphasis on tubulin post-translational modifications (polyglycylation and polyglutamylation) and microtubule severing, all of which are key to flagellar/ciliary assembly and motility. A couple of outliers relate to transcription and lipid catabolism, but the dominant signal is sperm flagellum/cilium function and its tubulin regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007288","count":5},{"id":"GO:1905419","count":5},{"id":"GO:0003351","count":5},{"id":"GO:0003353","count":5},{"id":"GO:0018094","count":5}]},{"hash":"26799605246579550","title":"Fungal-lectin innate immune activation","description":"The cluster is dominated by GO terms tied to the lectin pathway of complement activation, cellular response to molecules of fungal origin, and stimulatory C-type lectin receptor signaling, indicating a core theme of fungal recognition and lectin-mediated innate immunity. Additional terms about platelet activation and cell adhesion molecule regulation fit within inflammatory responses, while the developmental/morphogenesis terms appear less central to this core function. Overall, the label reflects the primary functional signal in the cluster with moderate confidence due to some heterogeneous terms.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":16},{"id":"GO:0071226","count":13},{"id":"GO:0001502","count":12},{"id":"GO:0010572","count":11},{"id":"GO:0060355","count":11}]},{"hash":"940620326747544194","title":"Growth Factor Signaling and Immune Cell Migration","description":"This cluster centers on GO terms for signaling cascades triggered by growth factors and cytokines (ERK cascade, PI3K activity, STAT tyrosine phosphorylation), along with cellular responses to PDGF, insulin, GM-CSF, and retinoic acid. It also includes calcium release and cell migration processes (smooth muscle and neutrophil chemotaxis), suggesting a cohesive theme of growth factor\u2013driven signaling networks that modulate immune cell movement and responses to external stimuli.","confidence":"High","size":25,"edges":250,"triangles":1380,"max_degree":24,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0070374","count":20},{"id":"GO:0043552","count":20},{"id":"GO:0036120","count":19},{"id":"GO:0042531","count":19},{"id":"GO:0051281","count":19}]},{"hash":"1088779151396532660","title":"Immune activation and phagocytosis","description":"The terms predominantly describe phagocytosis (recognition and engulfment), innate immune response, and complement activation, along with adaptive immune interactions (T cell costimulation and B cell activation) and cell adhesion. This suggests a cluster of immune effector and antigen-presenting functions, with some outlier terms (e.g., nervous system development) that are less central. Therefore, the label reflects the core theme of immune activation and phagocytic activity.","confidence":"Medium","size":25,"edges":7,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":11},{"id":"GO:0031295","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0045087","count":8},{"id":"GO:0006958","count":8}]},{"hash":"592270513853350977","title":"Ubiquitin-Dependent Protein Quality Control","description":"The top GO terms converge on ubiquitin-mediated processes (proteolysis, deubiquitination, and free ubiquitin chain dynamics) and ERAD-related proteostasis, with a stress-related xenobiotic response that supports a proteostasis-centric cluster. While transcription-related terms appear, the dominant signal points to protein quality control via ubiquitin pathways.","confidence":"Medium","size":25,"edges":14,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0006511","count":5},{"id":"GO:0071108","count":5},{"id":"GO:0035690","count":4},{"id":"GO:2000352","count":4}]},{"hash":"1820566595118139761","title":"Neural development and signaling cluster","description":"Enriched terms center on nervous system development (forebrain, nervous system, skeletal and heart development) and signaling processes (Rho signaling, calcium-dependent exocytosis). Ion transport and metabolic/immune response terms are present but appear secondary to the developmental signaling theme, making this label a reasonable best-fit with medium confidence. ","confidence":"Medium","size":25,"edges":214,"triangles":889,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071333","count":19},{"id":"GO:0043330","count":19},{"id":"GO:0045956","count":14},{"id":"GO:0006813","count":14},{"id":"GO:0007266","count":14}]},{"hash":"1773426352425793759","title":"Brain and Craniofacial Development","description":"This cluster shows enrichment for retina and brain development (retina development, brain segmentation, rhombomere development), as well as craniofacial and skeletal processes (roof of mouth development, osteoblast development, pituitary gland development) and neural signaling regulation (NMDA receptor activity), all pointing to neural and craniofacial development coordination.","confidence":"High","size":25,"edges":296,"triangles":2212,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":14},{"id":"GO:0002087","count":12},{"id":"GO:0002076","count":12},{"id":"GO:0006366","count":9},{"id":"GO:2000310","count":9}]},{"hash":"1795712029050668233","title":"Ubiquitin-dependent protein turnover and signaling regulation","description":"The top GO terms point strongly to ubiquitination processes (ubiquitin-dependent degradation, K63-linked and polyubiquitination, autoubiquitination) and related protein turnover, with accompanying signals for modulation of JNK cascades and GTPase activity. Some terms touch on development (neuron differentiation, placenta morphogenesis), but the dominant theme is ubiquitin-mediated tagging and degradation coupled with signaling control, suggesting a cluster of proteins involved in ubiquitin-dependent protein turnover and pathway regulation.","confidence":"High","size":25,"edges":4,"triangles":1,"max_degree":3,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0070534","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0046328","count":7},{"id":"GO:0000209","count":7}]},{"hash":"491826240884227609","title":"Membrane transport and ion homeostasis","description":"This cluster is dominated by membrane-associated transport activities: proton transmembrane transport and potassium import, plus related lipid dephosphorylation. The co-occurrence of hormone response and cardiovascular regulation terms suggests broader signaling roles linked to membrane function. Overall, the core theme is membrane transport and ion homeostasis, with signaling connections.","confidence":"Medium","size":25,"edges":137,"triangles":396,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0015991","count":12},{"id":"GO:1903249","count":11},{"id":"GO:0033574","count":11},{"id":"GO:1990573","count":11},{"id":"GO:0045822","count":11}]},{"hash":"768036240861213448","title":"Rho/Rac GTPase\u2013driven cell migration","description":"The cluster is dominated by GO terms tied to Rho and Rac small GTPase signaling, regulation of their pathways, and actin-based structures (filopodium/lamellipodium assembly) plus adhesion-dependent spreading and migration, pointing to cytoskeletal remodeling and motility as the central theme. Some immune and developmental terms (NK T cell differentiation, B cell maturation, heart development) may appear due to broader roles of these pathways, but the core signal is Rho/Rac-mediated cytoskeletal dynamics and cell movement.","confidence":"High","size":25,"edges":71,"triangles":59,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":20},{"id":"GO:0007507","count":16},{"id":"GO:0007264","count":16},{"id":"GO:1900026","count":16},{"id":"GO:0046847","count":16}]},{"hash":"1977081518766348016","title":"Ion and Metabolite Transporters","description":"This cluster is enriched for transmembrane transport GO terms across ions (sodium, potassium, nitrite, nitrate, phosphate) and small molecules (galactose, fucose, 4-hydroxyphenylacetate), plus a term for neurotransmitter loading into synaptic vesicles. The common theme is membrane transporter proteins that shuttle ions and metabolites across membranes, with vesicular transport components contributing to the pattern.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0098700","count":5},{"id":"GO:0042128","count":5},{"id":"GO:0015757","count":5}]},{"hash":"1368288778444407701","title":"Carbohydrate Metabolism and Catabolism","description":"The cluster is enriched for diverse carbohydrate-related processes (carbohydrate phosphorylation; glycerol-3-phosphate biosynthesis and glycerol catabolism; D-xylose, rhamnose, L-fucose, D-gluconate, and D-glucuronate catabolic pathways), indicating a coherent theme of sugar utilization and energy metabolism; a few GO terms (cellular response to interleukin-13, quorum sensing) are less central and may reflect broader annotations rather than core function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":5},{"id":"GO:0046167","count":5},{"id":"GO:0035963","count":4},{"id":"GO:0019301","count":4},{"id":"GO:0009372","count":4}]},{"hash":"1547843214072380374","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":46,"triangles":42,"max_degree":23,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":10},{"id":"GO:0045454","count":10},{"id":"GO:0006986","count":7},{"id":"GO:0070389","count":7},{"id":"GO:0051259","count":6}]},{"hash":"1023174312699636423","title":"Meiotic Chromatin Condensation and Synaptonemal Complex Assembly","description":"The top GO terms are strongly centered on chromatin regulation and chromosome dynamics during meiosis (condensation, heterochromatin formation, synaptonemal complex assembly, and maintenance of rDNA). This points to a cohesive theme of meiotic chromosome organization and chromatin remodeling, with a few additional vesicle trafficking or immune-related annotations likely reflecting multifunctional proteins rather than a dominant theme in this cluster.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007076","count":4},{"id":"GO:0030466","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0071169","count":3},{"id":"GO:0098943","count":3}]},{"hash":"2080209437520969488","title":"RNA processing and splicing regulation","description":"Most top GO terms cluster around post-transcriptional RNA processing, especially mRNA splicing via the spliceosome (including splicing, regulation of alternative splicing), mRNA stability under stress, and RNA modification. The presence of regulatory ncRNA-mediated gene silencing and translation initiation factor complex assembly further supports a cohesive role in RNA processing and expression regulation. Hence, the label reflects a cluster focused on RNA processing and splicing regulation.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":18},{"id":"GO:0048026","count":15},{"id":"GO:0031047","count":15},{"id":"GO:1901407","count":12},{"id":"GO:0006378","count":12}]},{"hash":"1765226361361716584","title":"Regulation of Golgi and endosome transport","description":"Most of the enriched GO terms cluster around intracellular trafficking through the Golgi apparatus and endosomes: intracellular protein transport, retrograde transport endosome-to-Golgi, and protein retention in the Golgi, plus regulation of GTPase activity and phosphatidylinositol signaling that modulate vesicle trafficking. Although some terms relate to odontogenesis and morphogenesis, the dominant signal is vesicle transport and Golgi dynamics, justifying the label.","confidence":"Medium","size":25,"edges":65,"triangles":7,"max_degree":10,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0048015","count":4},{"id":"GO:0042147","count":3},{"id":"GO:0045053","count":3}]},{"hash":"2200455256739003199","title":"Neuronal Development and Actin Remodeling","description":"Top terms emphasize neuron projection development, axon extension, and actin filament/network formation, pointing to proteins involved in neural development and cytoskeleton dynamics. Additional terms imply regulation of NF-kappaB signaling and inflammatory responses, suggesting these proteins are coordinated by signaling pathways. A hair follicle morphogenesis term is present but less central to the core neural/cytoskeleton theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1902042","count":4},{"id":"GO:0051639","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0010467","count":3},{"id":"GO:0006954","count":3}]},{"hash":"1838702038449646496","title":"Embryonic Organogenesis","description":"The cluster shows a concentration of terms tied to developmental processes across multiple organs (eye, heart, pancreas, pituitary, nervous system) plus transcriptional regulation by RNA Pol II, suggesting these proteins participate broadly in embryonic organ morphogenesis rather than a single tissue. ","confidence":"High","size":25,"edges":40,"triangles":11,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0048048","count":12},{"id":"GO:0060441","count":11},{"id":"GO:0043010","count":11},{"id":"GO:0006366","count":11}]},{"hash":"2201440353371170372","title":"Neurovascular GPCR signaling and inflammatory response","description":"Based on the top GO terms, this cluster centers on GPCR-mediated signaling that modulates vascular tone (blood pressure, vasoconstriction) and neural functions (enteric nervous system development, pain perception). It also includes responses to xenobiotic stimuli and lipopolysaccharide, suggesting a broader role in neurovascular signaling linked to inflammatory and stress responses. A modest contribution from electron transport chain terms may reflect member proteins with mitochondrial roles but does not define the core theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":16},{"id":"GO:0035025","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0010579","count":16},{"id":"GO:0042493","count":16}]},{"hash":"1983994765398385050","title":"Dopaminergic Neuron Development and Signaling","description":"This cluster centers on neuronal development and communication, highlighted by dopaminergic neuron differentiation, neuron projection development, brain development, and nerve impulse transmission. It also includes adhesion-related terms (cell adhesion, cell-matrix adhesion) and synaptic signaling via ionotropic glutamate receptors, suggesting formation and function of neural circuits with dopaminergic features. A transcriptional regulatory term further supports neural development processes. ","confidence":"High","size":25,"edges":9,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0031175","count":2},{"id":"GO:0071542","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0019226","count":2}]},{"hash":"1419774569251834187","title":"Developmental and Immune Signaling","description":"The set includes GO terms tied to development (midbrain development, Wnt signaling, angiogenesis) and immune/remodeling processes (defense response to Gram-positive bacteria, response to lipopolysaccharide, complement activation, plasminogen activation, fibrinolysis), along with negative regulation of transcription by RNA polymerase II. This suggests a broadly regulatory cluster implicated in developmental signaling with concurrent roles in immunity and extracellular remodeling, rather than a single narrow function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":9},{"id":"GO:0044130","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0042730","count":7}]},{"hash":"1748561307487368819","title":"RNA Pol II Termination and Calcium-NFAT Signaling","description":"This cluster\u2019s top GO terms prominently include termination of RNA polymerase II transcription (GO:0006369) and calcium-dependent signaling via the calcineurin-NFAT axis (GO:0051209, GO:0051533). These together suggest a core theme of gene expression regulation governed by calcium signaling, potentially relevant to neuronal contexts (e.g., neuron development). Some terms are obsolete or less relevant (e.g., PRPP biosynthesis, mRNA processing), which may reflect annotation noise or broader regulatory links, but the transcription termination and NFAT-calcium signaling signals provide a coherent overall theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006015","count":3},{"id":"GO:0021954","count":3},{"id":"GO:0070940","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0042769","count":2}]},{"hash":"1466734029623460570","title":"Antiviral response and translation control","description":"Enriched terms cluster around antiviral defense and translation regulation (interferon response, negative regulation of viral genome replication, translation and eIF2 alpha\u2013mediated control, RNA silencing). A few development-related terms appear but seem incidental to the main theme. ","confidence":"High","size":25,"edges":204,"triangles":773,"max_degree":23,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0045071","count":10},{"id":"GO:0009636","count":8},{"id":"GO:0035455","count":8},{"id":"GO:0006412","count":7},{"id":"GO:0021610","count":6}]},{"hash":"2209061382466009077","title":"Neural Development and Hedgehog-ERK Signaling","description":"This cluster is dominated by nervous system development terms (nervous system development, axonal fasciculation, paranodal protein localization) and neural signaling (dopamine response) alongside signaling pathways such as Smoothened/Hedgehog and ERK/MAPK cascades, suggesting a coherent role in neural development and associated signaling processes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007399","count":10},{"id":"GO:0001822","count":9},{"id":"GO:0000187","count":9},{"id":"GO:0007224","count":9},{"id":"GO:0070374","count":9}]},{"hash":"1266361821744003428","title":"Unknown","description":"The top GO terms span signaling (NF-kappaB regulation), cell division (mitotic cycle, cytokinesis), translation, actin organization, and various differentiation/development processes (astrocyte differentiation, heart morphogenesis) as well as xenobiotic response. This broad, mixed set does not point to a single coherent function or pathway shared by the cluster, indicating a heterogeneous collection rather than a unified theme.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043123","count":3},{"id":"GO:0032465","count":3},{"id":"GO:0014850","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0051764","count":3}]},{"hash":"315197169475244617","title":"Dopaminergic and cholinergic signaling regulation","description":"The cluster is enriched for terms directly related to neuromodulatory signaling, especially negative regulation of dopamine receptor signaling, dopamine transport, and GPCR-mediated acetylcholine signaling with adenosylate cyclase / cAMP involvement. This points to a cohesive theme of modulating dopaminergic and cholinergic pathways, potentially affecting neuronal signaling and plasticity. Some terms also touch on neural development (GABAergic interneuron migration) and immune differentiation, suggesting a few members may have broader roles, but the dominant signal is dopaminergic/cholinergic signaling regulation.","confidence":"High","size":25,"edges":219,"triangles":933,"max_degree":24,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":16},{"id":"GO:0090075","count":16},{"id":"GO:0007194","count":16},{"id":"GO:0016998","count":16},{"id":"GO:0040015","count":16}]},{"hash":"859506244465915890","title":"Antibiotic and Secondary Metabolite Biosynthesis","description":"This cluster is strongly enriched for biosynthetic processes, especially antibiotic biosynthesis (GO:0017000) with the largest count, and includes many other metabolite biosynthesis terms (alkaloids, steroids, lipids, PHB). This suggests the proteins participate in producing diverse secondary metabolites, rather than a single function. While a few terms (e.g., lung development) may be annotation noise, the dominant theme is biosynthesis of antibiotics and other secondary metabolites, justifying the label.","confidence":"Medium","size":25,"edges":61,"triangles":27,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":16},{"id":"GO:0055114","count":14},{"id":"GO:0046677","count":13},{"id":"GO:0031427","count":12},{"id":"GO:0030324","count":12}]},{"hash":"1867324472614935745","title":"Vascular and Cardiac Development Signaling","description":"Proteins in this cluster are strongly linked to developmental signaling pathways governing vascular and heart formation, including VEGF receptor signaling, HGF stimulus response, and collagen-activated RTK signaling, as well as ventricular cardiac muscle development. The presence of actin cytoskeleton organization and fibroblast migration suggests cytoskeletal remodeling and cell movement essential for morphogenesis and angiogenesis. Although a few terms (e.g., forebrain development, B cell differentiation) are present, the overall pattern centers on cardiovascular development and associated signaling and cytoskeletal dynamics.","confidence":"Medium","size":25,"edges":176,"triangles":561,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":24},{"id":"GO:0035729","count":24},{"id":"GO:0002333","count":24},{"id":"GO:0006939","count":24},{"id":"GO:0030866","count":24}]},{"hash":"1875827329391063025","title":"Calcium-Dependent Development and Angiogenesis Signaling","description":"This cluster centers on calcium signaling (positive regulation of Ca2+ release; Wnt calcium modulation) linked to development and vascular remodeling. Terms like metanephric collecting duct development, embryo implantation, and cell migration in sprouting angiogenesis point to developmental and angiogenic processes driven by Ca2+-regulated signaling, with supporting roles from hypoxia response and coagulation in tissue remodeling. Overall, the common thread is Ca2+-mediated signaling guiding development and angiogenesis, sometimes extending to neuronal plasticity via calcium signaling components.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051281","count":3},{"id":"GO:0048168","count":3},{"id":"GO:0007223","count":3},{"id":"GO:0072205","count":3},{"id":"GO:0042994","count":3}]},{"hash":"1643648915928762853","title":"Vesicle trafficking and synaptic exocytosis","description":"The term set centers on ER\u2013Golgi vesicle transport and intracellular transport, with several terms tied to synaptic vesicle exocytosis, long-term potentiation, and brain development. The presence of acrosome reaction also points to vesicle fusion processes, indicating a shared theme of vesicle trafficking and regulated exocytosis across contexts.","confidence":"High","size":25,"edges":7,"triangles":0,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0007340","count":5},{"id":"GO:0060291","count":5},{"id":"GO:0006886","count":5}]},{"hash":"2167146878660916322","title":"Neuronal vesicle trafficking and cytoskeleton dynamics","description":"The cluster is dominated by GO terms for endocytosis, exocytosis, regulation of GTPase activity, and actin crosslinking, all central to vesicle trafficking and cytoskeletal remodeling in neurons. The inclusion of long-term synaptic potentiation reinforces a synaptic function theme. While some terms touch broader contexts like myelination or heart development, the prevailing signal points to neuronal vesicle transport and actin dynamics as the unifying thread.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0045921","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0051764","count":3}]},{"hash":"531130632249967444","title":"Sodium and Potassium Ion Transport and Gradient","description":"The top GO terms cluster around transmembrane ion transport, especially Na+ export and K+ import, and establish/maintain the transmembrane electrochemical gradient, indicating a function centered on ion movement and membrane potential; occasional terms like visual perception or transcription may reflect multifunctional proteins or annotation noise.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0090662","count":3},{"id":"GO:0036376","count":3},{"id":"GO:1903278","count":3},{"id":"GO:1990573","count":3},{"id":"GO:0010248","count":3}]},{"hash":"187216364063782180","title":"Eye morphogenesis and brain segmentation cluster","description":"Based on the prominent GO terms, the proteins are enriched for camera-type eye development, retina development, embryonic eye morphogenesis, and brain segmentation/rhombomere development, indicating a cohesive role in ocular development and early neural patterning rather than general housekeeping processes.","confidence":"High","size":25,"edges":273,"triangles":1749,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0060041","count":11},{"id":"GO:0060441","count":10},{"id":"GO:0002087","count":10},{"id":"GO:0002076","count":10}]},{"hash":"1120415462951107057","title":"Postsynaptic density organization and AMPA receptor clustering","description":"The top terms indicate a strong focus on glutamatergic synapses, especially assembly of the postsynaptic density and clustering of AMPA receptors, along with associated signaling and synaptic plasticity (e.g., ephrin signaling and LTD). This suggests a cohesive theme of synapse structure and receptor organization rather than isolated cellular processes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":4},{"id":"GO:0097113","count":4},{"id":"GO:0097117","count":4},{"id":"GO:0031666","count":4},{"id":"GO:0035176","count":4}]},{"hash":"2249494249340256666","title":"Dopaminergic and Glycinergic Neurotransmission","description":"The top GO terms cluster around dopamine-related processes (dopamine catabolic process, dopamine uptake) and glycinergic synaptic transmission, along with glycine transport, which points to neurotransmitter handling at synapses. While there are some metabolic biosynthesis terms present, the dominant theme is amino acid neurotransmission involving dopamine and glycine (with taurine transport as a related transporter). This suggests the cluster mainly reflects neurotransmission processes rather than a single metabolic pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042420","count":3},{"id":"GO:0009229","count":3},{"id":"GO:0009228","count":3},{"id":"GO:0016260","count":3},{"id":"GO:0036233","count":2}]},{"hash":"1770157906308133139","title":"Integrin signaling and leukocyte migration","description":"The cluster centers on integrin-mediated adhesion and signaling, with strong signals for leukocyte migration, monocyte activation, and neutrophil extravasation, suggesting a core function in immune cell trafficking and activation. Peripheral terms like keratinocyte differentiation, Notch processing, and manganese response are present but do not override the dominant adhesion/migration theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033631","count":12},{"id":"GO:0007229","count":11},{"id":"GO:0002523","count":11},{"id":"GO:0007338","count":11},{"id":"GO:0030216","count":11}]},{"hash":"419774934020753276","title":"Neuronal GPCR-cAMP signaling and sensory perception","description":"The top GO terms cluster around visual perception, sensory perception of pain, dopaminergic synaptic transmission, and adenylate cyclase-activating GPCR signaling, all pointing to neural signaling and sensory processing. ERK cascade regulation and prostaglandin E stimulus further support signaling modulation in neurons. A couple of terms like heart development and saliva secretion appear as broader or peripheral roles, but the dominant theme is nervous system signaling and sensory function.","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":19},{"id":"GO:0007190","count":19},{"id":"GO:0007507","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0008542","count":19}]},{"hash":"338281758022189128","title":"Immune cell adhesion and cytotoxic regulation","description":"This cluster is dominated by innate immune response and multiple regulatory terms affecting macrophage, NK, and T cell activities, plus both hetero- and homo-typical cell-cell adhesion. The combination suggests proteins that mediate immune cell adhesion and modulate cytotoxic functions during host defense (with some tangential terms like symbiont entry and obsolete PI3K regulation). Overall, the theme is immune cell interaction and suppression/modulation of cytotoxic activity.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":12},{"id":"GO:0045087","count":12},{"id":"GO:0014068","count":12},{"id":"GO:0043031","count":11},{"id":"GO:0043318","count":11}]},{"hash":"1170846255313870119","title":"Neuronal synaptic signaling and spine morphogenesis","description":"The cluster is dominated by GO terms tied to neurotransmitter secretion, ephrin receptor signaling, synaptic plasticity, and glutamatergic transmission, along with dendritic spine morphogenesis and optic nerve development, pointing to neural connectivity and synaptic wiring. Some terms (hair cycle, complement activation, urogenital development) appear less related and may reflect broad or incidental annotations, but the core theme is neuronal synaptic function and morphogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007269","count":8},{"id":"GO:0048013","count":8},{"id":"GO:0048170","count":8},{"id":"GO:0051968","count":8},{"id":"GO:0060997","count":8}]},{"hash":"1796136415199798214","title":"Innate immune response and coagulation","description":"The most represented GO terms point to innate immunity (defense against Gram-positive bacteria, complement activation) and blood coagulation, suggesting a core theme of inflammatory and hemostatic functions. Some other terms (e.g., midbrain development, digestion) seem incidental noise or reflect broad involvement of some proteins, but the dominant pattern supports immune defense and coagulation. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":10},{"id":"GO:0006958","count":8},{"id":"GO:0007586","count":8},{"id":"GO:0050830","count":8}]},{"hash":"1178190708177754868","title":"Craniofacial and neural development","description":"GO terms point to developmental processes, especially craniofacial morphogenesis (palate development, ossification) and neural patterning (trigeminal nerve organization, branchiomotor neuron axon guidance) with semaphorin-plexin signaling. Regulation of GTPase activity supports the cytoskeletal changes needed for morphogenesis and axon navigation, indicating a cohesive program of craniofacial and neural tissue formation and broader endocrine development.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0021637","count":5},{"id":"GO:0021785","count":5}]},{"hash":"1887495016003824116","title":"Ion and Substrate Membrane Transporters","description":"This cluster is dominated by transmembrane transport GO terms, including ion transport (sodium, potassium, phosphate, nitrite, nitrate) and substrate transport (galactose, fucose, 4-hydroxyphenylacetate), plus a vesicular neurotransmitter loading term. The unifying theme is membrane transporter proteins handling ions and small molecules, with one vesicle-related function that fits the same transport theme.","confidence":"High","size":24,"edges":48,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":4},{"id":"GO:0042128","count":4},{"id":"GO:0015757","count":4},{"id":"GO:0035435","count":4},{"id":"GO:0035725","count":4}]},{"hash":"2036916947020284518","title":"Mitosis and DNA repair coordination","description":"This cluster is dominated by processes tied to cell division and genome maintenance: chromosome segregation, G2/M transition and exit from mitosis, SCF-dependent ubiquitin-proteasomal degradation, chiasma assembly, and DNA damage tolerance/repair such as nucleotide-excision repair and translesion synthesis. These collectively point to a cohesive theme of mitotic control coupled with genome integrity processes, with BMP signaling and viral processes appearing as less central associations. Overall, the top terms align well with a mitosis- and DNA repair\u2013focused cluster.","confidence":"High","size":24,"edges":274,"triangles":1981,"max_degree":23,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0007059","count":24},{"id":"GO:0031146","count":24},{"id":"GO:0000086","count":24},{"id":"GO:0016032","count":24},{"id":"GO:0070911","count":24}]},{"hash":"76575003758824155","title":"Vertebrate embryogenesis and vascular development","description":"The cluster is enriched for vertebrate developmental processes, including somitogenesis, floor plate development, placenta and lung vasculature development, suggesting coordination of neural patterning and vascular formation. Transcription-related GO terms (RNA polymerase II transcription, DNA-templated transcription) point to core transcriptional regulation driving these programs, while calcium signaling and cytokine-response terms reflect signaling context in development. Overall, it appears to be a transcription-regulatory module governing vertebrate embryogenesis with emphasis on vascular and neural tissues.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":18},{"id":"GO:0035470","count":11},{"id":"GO:0071277","count":10},{"id":"GO:0006351","count":10},{"id":"GO:0001892","count":10}]},{"hash":"1291922347445335173","title":"Neurodevelopmental differentiation","description":"The dominant GO terms describe neural development and cell fate specification across brain regions and sensory structures (spinal cord neurons, cortex interneurons, rhombomeres, retina), implying a cohesive neurodevelopmental module; a few non-neural terms reflect broader embryonic patterning but do not outweigh the neural theme.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":17},{"id":"GO:0021530","count":11},{"id":"GO:0021520","count":11},{"id":"GO:0021892","count":11},{"id":"GO:0060163","count":11}]},{"hash":"1121502488012660431","title":"Actin cytoskeleton remodeling and cell migration","description":"The top GO terms cluster around actin-based protrusions (filopodium, lamellipodium assembly), Rho GTPase signaling, integrin activation, and substrate adhesion-dependent cell spreading, all hallmarks of actin cytoskeleton remodeling driving cell migration and adhesion. While there are some developmental terms, the dominant theme is cytoskeletal dynamics guiding movement and attachment.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0046847","count":20},{"id":"GO:0090630","count":19},{"id":"GO:0030032","count":19},{"id":"GO:0060313","count":18},{"id":"GO:0043314","count":18}]},{"hash":"53354370789754791","title":"Rho GTPase\u2013driven actin remodeling and migration","description":"This cluster\u2019s dominant themes are regulation of Rho family GTPases and small GTPase signaling, actin cytoskeleton organization, lamellipodium assembly, and cell migration, indicating coordinated actin remodeling and motility. The heart development and IL-2-related terms likely reflect context-specific roles of cytoskeletal dynamics in different tissues or signaling contexts.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0007264","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0030036","count":5}]},{"hash":"2251950111121991213","title":"Dendritic Spine Development and Endocytic Trafficking","description":"This cluster is dominated by terms for dendritic spine development/morphogenesis, Rac signaling, endocytosis, and membrane trafficking (Golgi to plasma membrane), with supporting notes on hippocampus development and gene expression regulation. These collectively indicate neuronal synaptic development and membrane trafficking as the core theme, with immune/stress terms likely serving as noise.","confidence":"High","size":24,"edges":204,"triangles":867,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042832","count":16},{"id":"GO:0035900","count":15},{"id":"GO:0060999","count":15},{"id":"GO:0061001","count":14},{"id":"GO:0006897","count":14}]},{"hash":"936543579733625741","title":"Embryonic development and organogenesis","description":"The proteins are connected by developmental processes: placenta/trophoblast differentiation, pancreatic/endocrine system development, cartilage morphogenesis, left-right patterning, and EMT-related heart formation, plus transcriptional regulation and proteolysis, pointing to a cohesive role in embryonic tissue morphogenesis and gene control during organ formation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0060806","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0006351","count":5}]},{"hash":"1573494487930110784","title":"Neural and muscle development with cell cycle regulation","description":"The top GO terms point to neural signaling (excitatory postsynaptic potential), Schwann cell development, and myoblast fusion for muscle formation, alongside core cell cycle processes (mitosis, G1/S transition, DNA replication, kinetochore localization). This suggests a developmental program that ties neural/glial and muscular differentiation to proliferation and cell-cycle control. Although the terms span both neural and muscular contexts, the shared theme is development coupled with cell cycle dynamics, justifying a single labeled cluster. ","confidence":"Medium","size":24,"edges":215,"triangles":1093,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":14},{"id":"GO:0014044","count":14},{"id":"GO:0000278","count":13},{"id":"GO:0000082","count":12},{"id":"GO:0042220","count":12}]},{"hash":"1661761225284978062","title":"Glycan biosynthesis and glycosylation","description":"This cluster is dominated by GO terms related to the biosynthesis of glycans and glycosylation processes, including proteoglycan biosynthesis (heparin, chondroitin sulfate, and heparan sulfate), as well as general carbohydrate metabolism (glucose, starch, and glycogen pathways) and even cell wall organization. The common thread is synthesis and modification of complex carbohydrates and glycoconjugates, suggesting a cohesive glycan biosynthesis theme for the cluster.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006486","count":5},{"id":"GO:0005978","count":4},{"id":"GO:0071555","count":3},{"id":"GO:0019252","count":3},{"id":"GO:0006006","count":3}]},{"hash":"1335573010467825806","title":"Dopaminergic GPCR-cAMP Signaling","description":"This cluster is dominated by GO terms for dopamine receptor signaling, adenylate cyclase activation/inhibition, and their negative regulation, along with downstream effects like muscle relaxation and prostaglandin response, indicating a set of proteins that participate in GPCR-mediated cAMP signaling and its modulation.","confidence":"High","size":24,"edges":44,"triangles":16,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":24},{"id":"GO:0008283","count":24},{"id":"GO:0071380","count":24},{"id":"GO:0060160","count":23},{"id":"GO:0090075","count":23}]},{"hash":"1522045728029258666","title":"Craniofacial development and odontogenesis","description":"This cluster is dominated by GO terms related to development of the craniofacial region and related structures: tooth formation (odontogenesis), cranial skeleton morphogenesis, palate/roof of mouth development, and inner ear and pituitary development, with supporting signals from Wnt pathways and transcriptional regulation. The shared theme is embryonic craniofacial patterning and formation of sensory and cranial structures, suggesting a cohesive developmental program.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0030901","count":8},{"id":"GO:0090009","count":6},{"id":"GO:0060021","count":6},{"id":"GO:0048839","count":6}]},{"hash":"45714558868623084","title":"Multicellular Development and Growth","description":"The top GO terms point to broad developmental and proliferative processes across tissues (mitotic cell cycle, cell division, organ morphogenesis, and development), along with differentiation (B cell differentiation) and tissue-specific guidance (photoreceptor axon guidance, skeletal morphogenesis). Additional terms like mRNA capping and GTPase regulation support general cellular growth and trafficking rather than a single pathway. This suggests a broad developmental/growth theme rather than a specific molecular function, hence a general label of multicellular development and growth.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006370","count":2}]},{"hash":"2058079704891468474","title":"RNA-based translational control and gene silencing","description":"This cluster centers on post-transcriptional gene regulation: many proteins link to translation and its initiation control via eIF2\u03b1 phosphorylation, plus RNA silencing and miRNA metabolism, suggesting a common theme of RNA-level regulation of gene expression. Some developmental terms appear incidental, but the dominant signal is translational control and RNA-mediated regulation.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0046677","count":8},{"id":"GO:0021610","count":5},{"id":"GO:0045433","count":5},{"id":"GO:0030423","count":5}]},{"hash":"2220063915004358358","title":"Chondrogenesis and ECM organization","description":"The cluster prominently features cartilage condensation and collagen fibril organization, pointing to cartilage development and extracellular matrix (ECM) assembly. Supportive terms like actin filament bundling and cell migration align with morphogenetic cell movements, while COPII vesicle loading and intracellular transport reflect secretory processes needed to deposit ECM components. FGF response and epithelial polarity hints underscore developmental signaling and tissue organization. Collectively, these terms suggest a cohort of proteins involved in chondrogenesis and ECM remodeling.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0090110","count":3},{"id":"GO:0045737","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0090162","count":3}]},{"hash":"921384708705427797","title":"Dopaminergic signaling modulation in neural development","description":"The terms show strong emphasis on regulating dopamine receptor signaling and related GPCR/adenylate cyclase activity, plus dopamine transport, suggesting a cluster of proteins involved in modulating dopaminergic signaling. The presence of neural development terms (GABAergic interneuron migration) and broader developmental regulation supports a theme of signaling control connected to neural development, with a few peripheral terms that may reflect broader biology. ","confidence":"High","size":24,"edges":246,"triangles":1472,"max_degree":23,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":24},{"id":"GO:0090075","count":24},{"id":"GO:0007194","count":24},{"id":"GO:0016998","count":24},{"id":"GO:0040015","count":24}]},{"hash":"283814920646042346","title":"Tight Junction Regulation and Inflammatory Signaling","description":"These proteins cluster around maintaining epithelial barrier function and coordinating inflammatory signaling. The prominent GO terms\u2014bicellular tight junction assembly, NF-kappaB signaling, Rho-mediated signaling, LPS signaling, and PI3K/AKT pathways\u2014point to junction dynamics coupled with immune and survival signaling. Additional links to autophagy, anti-apoptotic regulation, and angiogenesis suggest broader remodeling and tissue response roles beyond just barrier assembly.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":4},{"id":"GO:0051897","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0031663","count":2}]},{"hash":"712610201121441042","title":"Vesicle trafficking and membrane transport","description":"The top GO terms cluster around intracellular membrane movement and vesicle dynamics, including Golgi-to-plasma membrane transport, endocytosis, and regulation of vesicle exocytosis and vacuolar/MVB fusion. Although there are some development-related terms, the common theme across the majority of terms is vesicle trafficking and membrane transport, suggesting this cluster comprises proteins involved in membrane trafficking processes rather than a single signaling pathway.","confidence":"High","size":24,"edges":81,"triangles":66,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006893","count":7},{"id":"GO:0006897","count":6},{"id":"GO:0032889","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0007420","count":6}]},{"hash":"1299732476912275809","title":"Neurodevelopmental Signaling and Synaptic Plasticity","description":"The prominent terms point to nervous system development, learning, and synapse structural plasticity, with signaling pathways like Smoothened (Hedgehog) and ephrin receptor signaling contributing to neural connectivity and plasticity. While there are also development terms for heart and kidney, the cohesive theme appears to be neurodevelopment and synaptic signaling, making this label a reasonable, specific summary of the cluster. The network connectivity is modest, so a confident but cautious Medium label is appropriate.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":9},{"id":"GO:0043552","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0007224","count":8},{"id":"GO:0007612","count":8}]},{"hash":"1306540051459130736","title":"Cerebellar neural development and Bergmann glia differentiation","description":"Top GO terms cluster around cerebellar cortex formation, Bergmann glial differentiation, neuron development, and regulation of axon growth, suggesting a shared program of cerebellar neural development and glial maturation. Some signaling terms (insulin/T cell receptor pathways) may reflect broad developmental signaling co-opted in this neural context.","confidence":"High","size":24,"edges":73,"triangles":89,"max_degree":20,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0060020","count":12},{"id":"GO:0021697","count":12},{"id":"GO:0048679","count":12},{"id":"GO:0008285","count":12},{"id":"GO:0008286","count":12}]},{"hash":"793073417504987119","title":"Cardiac conduction and ion transport regulation","description":"This cluster is enriched for GO terms related to cardiac electrical activity and heart rate control, including regulation of heart rate by cardiac conduction, AV node action potentials, and membrane depolarization/repolarization in atrial and ventricular myocytes, as well as positive regulation of sodium ion transport. Although terms for proteolysis, innate immune response, and bone development appear, the strongest theme centers on heart conduction and ion handling, suggesting these proteins participate in cardiac electrical activity and ion transport regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006508","count":10},{"id":"GO:0086091","count":9},{"id":"GO:0007157","count":9},{"id":"GO:0010765","count":9},{"id":"GO:0045087","count":9}]},{"hash":"2232003212757375630","title":"Dopamine/Adrenergic GPCR-cAMP Signaling","description":"The cluster is dominated by GO terms describing GPCR signaling that modulates cAMP production via adenylyl cyclase, including dopamine- and adrenergic-receptor pathways, and downstream effects such as GTPase activity regulation and PLC activation, with notes on heart development and muscle relaxation. This points to a cohesive theme of dopaminergic/adrenergic GPCR signaling controlling cAMP signaling in muscle/heart contexts.","confidence":"High","size":24,"edges":11,"triangles":3,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":24},{"id":"GO:0007507","count":24},{"id":"GO:0007603","count":24},{"id":"GO:0010513","count":24},{"id":"GO:0043547","count":24}]},{"hash":"178713657895509298","title":"Brain visual and dopaminergic signaling","description":"The cluster is dominated by terms related to visual perception and learning, dopaminergic synaptic transmission, and ERK signaling, which together point to neural sensory processing and reward pathways. Additional terms about morphine response and prostaglandin stimulus reinforce a neural signaling/pain modulation theme. Some outliers (heart development, brain RAS) may reflect broader gene functions or annotation noise, but the core pattern centers on brain visual and dopaminergic signaling.","confidence":"High","size":24,"edges":211,"triangles":940,"max_degree":22,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":17},{"id":"GO:0007507","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0008542","count":17},{"id":"GO:0043547","count":17}]},{"hash":"880236301240085545","title":"Neural sensory signaling and drug response","description":"This cluster is dominated by GO terms tied to neural signaling and sensory processing, including dopaminergic synaptic transmission, visual perception and learning, and behavioral responses to cocaine, along with ERK signaling and GTPase regulation. While terms like heart development and macrophage chemotaxis appear, the strongest shared theme is neural communication and drug-related behavioral responses, suggesting a cohesive cluster of neural/sensory signaling functions with drug sensitivity. ","confidence":"Medium","size":24,"edges":167,"triangles":481,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":22},{"id":"GO:0007507","count":22},{"id":"GO:0019233","count":22},{"id":"GO:0008542","count":22},{"id":"GO:0043547","count":22}]},{"hash":"1775977833927857365","title":"Neural development and axon guidance with ECM adhesion","description":"This cluster is strongly enriched for terms related to neural development, especially motor neuron migration, axon guidance, and axonogenesis in the peripheral nervous system, along with receptor clustering and cell\u2013matrix adhesion, suggesting coordinated neural morphogenesis and axon pathfinding. A couple of terms on gonad/uterine development may reflect broader developmental roles of some proteins, but the dominant signal is neural development.","confidence":"High","size":24,"edges":87,"triangles":64,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0097477","count":10},{"id":"GO:0070527","count":10},{"id":"GO:0008045","count":9},{"id":"GO:0048936","count":9},{"id":"GO:0007160","count":9}]},{"hash":"1457167087906855381","title":"Autonomic GPCR signaling and thermoregulation","description":"Top GO terms indicate strong representation of pain perception, temperature response, and GPCR-mediated adenylate cyclase activation, pointing to neural/autonomic signaling and thermoregulatory processes. Additional terms for saliva secretion and blood pressure regulation reinforce an autonomic regulation theme, while energy metabolism terms like electron transport chain/membrane potential align with neural activity. Overall, the cluster seems best described as autonomic GPCR signaling with thermoregulatory and sensory roles.","confidence":"High","size":24,"edges":4,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0007190","count":13},{"id":"GO:0010579","count":13}]},{"hash":"1839223980630630772","title":"DNA replication and cell cycle machinery","description":"This cluster shows strong enrichment for mitotic cell cycle, DNA replication, DNA repair, and DNA-templated transcription, pointing to a coherent theme of DNA maintenance and cell cycle progression. While innate immune response and developmental terms are also present, the dominant signals center on replication and division, suggesting these proteins function together in DNA synthesis, repair, and cell-cycle control.","confidence":"High","size":24,"edges":7,"triangles":2,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000278","count":22},{"id":"GO:0006260","count":22},{"id":"GO:0045087","count":21},{"id":"GO:0006351","count":21},{"id":"GO:0071276","count":21}]},{"hash":"934169077129714265","title":"Developmental Regulation and Stress Responses","description":"This cluster centers on developmental processes (multicellular and forebrain development) and transcriptional regulation (DNA-templated transcription, gene expression control). It also includes stress and immune-related responses (cellular response to cadmium, defense against Gram-positive bacteria, response to muramyl dipeptide). The mix of developmental and stress/immune GO terms suggests proteins involved in developmentally regulated transcriptional programs that can also engage stress or immune signaling, hence the label Developmental Regulation and Stress Responses.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0051092","count":6},{"id":"GO:0032495","count":6}]},{"hash":"1066562915266468532","title":"Epithelial/Endothelial Barrier Formation & Immune Signaling","description":"The top terms highlight tight junction assembly, epithelial polarity, and endothelial barrier establishment, pointing to barrier integrity. They are complemented by actin dynamics and cell migration, and by immune-related pathways such as B cell receptor signaling, B cell proliferation, and TGF-beta response, suggesting a cluster of proteins coordinating barrier function and immune communication.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045806","count":6},{"id":"GO:0070830","count":5},{"id":"GO:0071560","count":5},{"id":"GO:0030890","count":5},{"id":"GO:0051017","count":5}]},{"hash":"645074977848321803","title":"ER-Golgi trafficking and nuclear envelope reassembly","description":"The top GO terms indicate strong enrichment for ER-to-Golgi vesicle transport and retrograde Golgi-to-ER transport, along with nuclear pore complex assembly and mitotic nuclear membrane reassembly, plus mRNA transport and GTPase regulation with TORC1 signaling. Together these terms suggest a coherent theme of vesicle trafficking between the ER and Golgi and nuclear envelope dynamics during the cell cycle, justifying this label.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0007084","count":3}]},{"hash":"1777378003869010809","title":"Mammary Epithelial Proliferation and Lactation Signaling","description":"This cluster is enriched for GO terms related to mammary gland epithelial cell proliferation and lactation, along with related signaling pathways (Wnt, insulin) and cell cycle processes, suggesting a coherent motif of mammary gland development and function.","confidence":"High","size":24,"edges":8,"triangles":1,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0033601","count":5},{"id":"GO:0060153","count":4}]},{"hash":"703544280776945337","title":"Developmental signaling and cytoskeleton remodeling","description":"This cluster centers on growth-factor\u2013mediated signaling and cytoskeletal organization across multiple development-related tissues. Dominant GO terms include forebrain development, vascular/endothelial signaling (VEGF receptor pathway, hepatocyte growth factor response, collagen-activated RTK signaling), and cytoskeleton organization (cortical actin). Additional terms span cardiac, smooth muscle, and fibroblast migration, all tying to developmental processes that rely on signaling-driven cytoskeletal dynamics and cell movement. Overall, the proteins likely coordinate developmental signaling with actin remodeling across neural, vascular, and mesenchymal contexts.","confidence":"High","size":24,"edges":271,"triangles":1920,"max_degree":23,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":24},{"id":"GO:0035729","count":24},{"id":"GO:0002333","count":24},{"id":"GO:0006939","count":24},{"id":"GO:0030866","count":24}]},{"hash":"2042890279742957340","title":"Neural development and synaptic signaling","description":"The cluster is enriched for neural-related terms (brain development, nervous system development) and synaptic function (regulation of synaptic vesicle exocytosis), with supporting links to cytoskeletal dynamics (regulation of Rho signaling) that drive development and connectivity. Additional terms like myoblast fusion, proliferation, and apoptosis point to broader developmental programs, but the strongest signal centers on neural development and synaptic regulation.","confidence":"Medium","size":24,"edges":198,"triangles":741,"max_degree":21,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":9},{"id":"GO:0007420","count":7},{"id":"GO:0007520","count":7},{"id":"GO:0008284","count":6},{"id":"GO:0006915","count":6}]},{"hash":"38975439720002306","title":"Embryonic organogenesis and neural development","description":"Most top GO terms describe transcription by RNA polymerase II and its negative regulation, together with multiple developmental processes (eye, brain, inner ear, craniofacial roof of mouth, hypothalamus, midbrain, primitive streak). This pattern points to a cluster of regulators coordinating embryonic organogenesis and neural development via transcriptional control.","confidence":"High","size":24,"edges":56,"triangles":17,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0006366","count":12},{"id":"GO:0021979","count":10},{"id":"GO:0060441","count":9},{"id":"GO:0043010","count":9}]},{"hash":"756558710825180451","title":"Neural development and synaptic signaling","description":"The cluster is strongly enriched for nervous system-related processes, including nervous system development and brain development, and it also features signaling pathways key to neural function such as Roundabout (axonal guidance), Smoothened (Hedgehog) signaling, Rho protein signaling, and regulation of synaptic vesicle exocytosis. While a few terms are less directly neural (e.g., some immune signaling terms), the dominant GO terms point to coordinated neural development and synaptic signaling roles. ","confidence":"High","size":24,"edges":166,"triangles":399,"max_degree":18,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0001822","count":7},{"id":"GO:0001778","count":7},{"id":"GO:0050852","count":6}]},{"hash":"1292510491885749488","title":"Plasma membrane trafficking and actin remodeling","description":"From the top GO terms, the cluster is enriched for processes involved in moving proteins to the plasma membrane (positive regulation of protein localization to plasma membrane, exocytosis), uptake or recycling at the membrane (endocytosis), and reorganizing the actin cytoskeleton (stress fiber assembly, ruffle assembly). This points to a cohesive theme of membrane trafficking coupled with cytoskeletal dynamics, with a few terms like mitotic cell cycle or sporulation assembly being broader contexts rather than core drivers here.","confidence":"High","size":24,"edges":73,"triangles":38,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903078","count":8},{"id":"GO:0045956","count":8},{"id":"GO:0031321","count":8},{"id":"GO:0071260","count":8},{"id":"GO:0000278","count":7}]},{"hash":"591947708250817715","title":"Developmental signaling and organ morphogenesis","description":"The terms converge on signaling pathways (Wnt, ERK) that drive tissue development and morphogenesis across multiple organs (hair follicle, lung, salivary gland) and include nervous system formation, suggesting a cluster of proteins involved in developmental signaling guiding organ formation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0071338","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0021762","count":4}]},{"hash":"1777151436693702801","title":"Unknown","description":"The top GO terms span diverse processes (Wnt signaling, ephrin receptor signaling, synaptic plasticity regulation) and separate processes related to telomere maintenance and spindle assembly, with some terms obsolete. This mixture lacks a clear, single functional theme tying the proteins together, so a concise functional label cannot be confidently assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":4},{"id":"GO:1900383","count":4},{"id":"GO:1901187","count":4},{"id":"GO:1904743","count":3},{"id":"GO:0070212","count":3}]},{"hash":"2155743080789610340","title":"Cardiovascular and immune development","description":"The top GO terms cluster around heart development, endothelial/vascular processes, and immune cell differentiation (dendritic cells, myeloid progenitors), plus adhesion and complement activation. While diverse, these terms point to developmental programs governing cardiovascular tissues and immune lineage differentiation, with associated signaling and cell-cell interactions. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0007286","count":4},{"id":"GO:0071639","count":4}]},{"hash":"1724078603100330982","title":"Coagulation and Complement Activation in Inflammation","description":"Top GO terms indicate a module centered on blood coagulation, complement activation (classical and lectin pathways), inflammatory responses (LPS response, leukocyte migration), and endothelial barrier regulation, with supporting signals of tissue remodeling. This suggests a cohesive group of proteins involved in coagulation-linked innate immunity and vascular inflammation, despite some outliers possibly due to annotation noise.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":10},{"id":"GO:0006958","count":10},{"id":"GO:0032496","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0001867","count":8}]},{"hash":"402430983388027813","title":"Unknown","description":"The GO terms cover many unrelated biological processes across tissues (DNA replication; placental and lung development; myelination; immune signaling; metabolic stress; apoptosis). There is no clear shared function tying these proteins together, and there is only a single edge, suggesting weak cohesion. ","confidence":"","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0031953","count":2},{"id":"GO:0042149","count":2},{"id":"GO:0022011","count":2},{"id":"GO:2001241","count":2}]},{"hash":"219111256487795822","title":"Interferon-driven Antiviral Response","description":"The top GO terms point to innate immunity and antiviral signaling, with strong representation of innate immune response, cellular response to type I interferon, dsRNA sensing, and defense against virus. Additional terms like hypoxia, mitochondrial distribution, and GPCR signaling likely reflect broader cellular stress or regulation rather than redefining the core function. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0071320","count":2},{"id":"GO:0055059","count":2},{"id":"GO:0048312","count":2},{"id":"GO:0008277","count":2}]},{"hash":"675079779296019536","title":"Developmental morphogenesis and ECM-integrin signaling","description":"The top GO terms point to multiple embryonic development processes (lung, ventral spinal cord, palatal shelf morphogenesis, mesoderm differentiation) and to cell-ECM interactions (integrin-mediated signaling, collagen fibril organization, VEGF signaling). This suggests a coherent theme of tissue morphogenesis governed by ECM remodeling and adhesion signaling, with Notch pathway regulation as a modulating developmental signal. An obsolete oxidation-reduction term appears as noise. ","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030324","count":5},{"id":"GO:0045746","count":5},{"id":"GO:0055114","count":5},{"id":"GO:1990134","count":4},{"id":"GO:0033631","count":4}]},{"hash":"1025624044455382823","title":"Innate Immune Signaling and Cytoskeletal Remodeling","description":"The cluster is enriched in innate immune terms (defense against Gram-positive bacteria, innate immune response, defense against virus) and cytokine-mediated signaling, indicating a core immune-defense function. The presence of actin filament depolymerization suggests cytoskeletal remodeling accompanying immune responses, while broader signaling terms like Wnt and spindle assembly hint at general cellular signaling involvement. Taken together, the set likely reflects coordinated immune signaling with cytoskeletal changes rather than a single, narrow pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050830","count":10},{"id":"GO:0071260","count":9},{"id":"GO:0045087","count":9},{"id":"GO:0051607","count":9},{"id":"GO:0030433","count":8}]},{"hash":"799748723976004743","title":"Vertebrate organogenesis and transcriptional regulation","description":"The cluster\u2019s top GO terms point to development of multiple vertebrate organs (pituitary, cartilage, spleen, gonad, roof of the mouth) combined with transcriptional control (negative regulation of RNA Pol II) and epigenetic modification (histone demethylation). This suggests a theme of broad developmental regulation and differentiation guided by transcriptional and epigenetic mechanisms, with some terms reflecting related apoptosis or broad immune/fertilization processes that can occur during development. Overall, the data support a cohesive theme of vertebrate organogenesis coupled with gene expression regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0007338","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0034720","count":4},{"id":"GO:0051216","count":4}]},{"hash":"284578581293704785","title":"Embryonic development and tissue morphogenesis","description":"The GO terms cluster around developmental processes across multiple tissues (placenta, cartilage, pancreas, heart) and morphogenic events (left-right patterning, EMT, differentiation), suggesting a cohesive group of genes involved in embryonic tissue formation rather than a single cellular function.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3}]},{"hash":"1430922908997373827","title":"Mitochondrial and lipid metabolism cluster","description":"The top GO terms converge on mitochondrial complex IV assembly and lipid/retinol/vitamin A metabolism, with adipose development also represented, suggesting a metabolic focus centered on mitochondrial function and lipid/vitamin pathways; peripheral terms like iron homeostasis and erythrocyte differentiation appear secondary.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":3},{"id":"GO:0070863","count":2},{"id":"GO:0055072","count":2},{"id":"GO:0030218","count":2},{"id":"GO:0071284","count":2}]},{"hash":"1063406271753029479","title":"Neural development and myelination","description":"The top GO terms emphasize nervous system functions like auditory detection, myelination, paranodal junction assembly, and neural cell adhesion, suggesting proteins linked to neural development and nerve insulation/connectivity.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":13},{"id":"GO:0042552","count":13},{"id":"GO:0014068","count":13},{"id":"GO:0030913","count":13},{"id":"GO:0043031","count":12}]},{"hash":"53254334146379380","title":"Dopaminergic and opioid GPCR signaling","description":"This cluster centers on GPCR-mediated neuromodulatory signaling, notably dopamine signaling, morphine response, and regulation of adenylate cyclase (cAMP pathway), with associated dopamine transport and acetylcholine receptor\u2013related signaling. A few outlier terms (e.g., cell wall catabolic processes) temper the theme, but the dominant pattern is neuronal GPCR signaling and its modulation by dopaminergic and opioid pathways.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043278","count":17},{"id":"GO:0060160","count":16},{"id":"GO:0090075","count":16},{"id":"GO:0007194","count":16},{"id":"GO:0016998","count":16}]},{"hash":"494618585362828883","title":"Dopaminergic GPCR Signaling Regulation","description":"The top GO terms are dominated by modulation of dopamine signaling and GPCR-related pathways (negative regulation of dopamine receptor signaling, negative regulation of adenylate cyclase activity, acetylcholine receptor signaling) plus dopamine transport and neural development terms (GABAergic interneuron migration). This suggests a cohesive theme around neuronal neurotransmission regulation, especially dopaminergic signaling, with a few outliers (cell wall catabolic process, thymocyte differentiation) that may reflect annotation noise. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":22},{"id":"GO:0090075","count":22},{"id":"GO:0007194","count":22},{"id":"GO:0016998","count":22},{"id":"GO:0040015","count":22}]},{"hash":"34112511699063788","title":"Inflammation-driven Cardiovascular GPCR Signaling","description":"This cluster centers on inflammatory and lipopolysaccharide response terms, with strong ties to vascular and heart-related processes (vasoconstriction, heart development) and signaling via neuropeptides and GPCR pathways, suggesting coordinated immune-vascular GPCR signaling in this protein group. The presence of GTPase activity regulation and GPCR signaling terms further supports a signaling-communication theme bridging inflammation and cardiovascular/neuronal signaling.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0045907","count":7},{"id":"GO:0032496","count":7},{"id":"GO:0007507","count":7}]},{"hash":"530251859548649807","title":"GPCR-mediated neural signaling","description":"This cluster is dominated by GO terms related to neural signaling and neuromodulation, including GPCR internalization, regulation of glutamatergic synaptic transmission, and responses to psychoactive substances (morphine, amphetamine), as well as prepulse inhibition and prostaglandin signaling. A couple of terms (cell wall catabolic process, blood coagulation) are less aligned, likely reflecting cross-species or annotation noise, but the core theme points to GPCR-driven neural signaling and synaptic regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016998","count":8},{"id":"GO:0008542","count":8},{"id":"GO:0043278","count":8},{"id":"GO:0051930","count":8},{"id":"GO:0060134","count":8}]},{"hash":"1778191441007878491","title":"Growth Factor Signaling and MAPK-Calcium Signaling","description":"The cluster is enriched for growth factor\u2013related responses (PDGF, insulin, CSF stimuli), collagen-activated RTK signaling, and downstream MAPK/ERK cascades with calcium release, pointing to a cohesive role in receptor tyrosine kinase\u2013driven signaling that converges on MAPK and calcium pathways to regulate cell behavior.","confidence":"High","size":23,"edges":135,"triangles":338,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":21},{"id":"GO:0036120","count":20},{"id":"GO:0038063","count":20},{"id":"GO:0042531","count":20},{"id":"GO:0051281","count":20}]},{"hash":"1171352680981566876","title":"Autophagy and vesicle trafficking","description":"The top GO terms cluster around autophagy-related processes (autophagosome assembly; autophagy of mitochondrion; cytoplasm to vacuole targeting by the Cvt pathway; protein targeting to vacuole involved in autophagy) and vesicle transport between ER and Golgi, suggesting a concerted role in autophagic flux and related vesicle trafficking to vacuoles. Stress-response terms (to hydrogen peroxide and metal ions) may reflect autophagy induction under stress, reinforcing the theme. Overall, a cohesive autophagy/vesicle-traffic program.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0010040","count":6},{"id":"GO:0070301","count":6},{"id":"GO:0043278","count":6},{"id":"GO:0071211","count":6}]},{"hash":"1502395732521030725","title":"Ubiquitin-mediated protein quality control and ER stress","description":"This cluster centers on deubiquitination, ERAD/ER stress signaling, autophagy regulation, and related protein-quality-control processes, with a few broader terms reflecting multifunctional roles.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":19},{"id":"GO:0097237","count":18},{"id":"GO:0006517","count":18},{"id":"GO:0033132","count":18},{"id":"GO:0006357","count":18}]},{"hash":"876409303405636299","title":"Adaptive immune signaling and angiogenesis","description":"The cluster shows strong representation of adaptive immunity terms (adaptive immune response, B cell receptor signaling, Fc-epsilon receptor signaling, IL-2 production) together with angiogenesis-related processes (angiogenesis, endothelial cell migration), and ERK pathway modulation (positive/negative regulation). This points to proteins that coordinate immune activation with vascular remodeling, a common theme in inflammatory contexts.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0002250","count":15},{"id":"GO:0070374","count":14},{"id":"GO:0043536","count":13},{"id":"GO:0001525","count":13},{"id":"GO:1900042","count":13}]},{"hash":"1810734531137291074","title":"Developmental Differentiation Across Tissues","description":"This cluster aggregates genes involved in broad developmental programs influencing multiple lineages, including neural differentiation (oligodendrocyte, motor neuron, interneuron), subpallial neuron fate, and organogenesis in heart, vasculature, pancreas, and lungs. The common thread is transcriptional regulation by RNA polymerase II guiding tissue-specific differentiation, suggesting a cross-tissue developmental differentiation program.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":20},{"id":"GO:0021530","count":16},{"id":"GO:0021520","count":16},{"id":"GO:0021892","count":16},{"id":"GO:0060163","count":16}]},{"hash":"418047612082139663","title":"Spliceosome-mediated mRNA processing and stability","description":"The cluster is dominated by GO terms revolving around mRNA splicing via the spliceosome, including regulation of splicing, mRNA modification, and mRNA stabilization/stability, with an additional link to translation initiation factor complex assembly. This points to a group of proteins involved in mRNA maturation and post-transcriptional control rather than primary transcription or translation execution alone. Confidence: High","confidence":"","size":23,"edges":145,"triangles":348,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":14},{"id":"GO:0006378","count":14},{"id":"GO:0010610","count":13},{"id":"GO:0048025","count":12},{"id":"GO:1905663","count":10}]},{"hash":"936220749144806306","title":"mRNA splicing and stability regulation","description":"This cluster centers on post-transcriptional RNA processing: both positive and negative regulation of mRNA splicing via the spliceosome, regulation of alternative splicing, mRNA modification/stabilization, and related processes like polyadenylation and translation initiation complex assembly. The convergence on RNA maturation and stability suggests a coherent group of proteins coordinating RNA processing and translation readiness.","confidence":"High","size":23,"edges":251,"triangles":1730,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":17},{"id":"GO:0006378","count":15},{"id":"GO:0048025","count":14},{"id":"GO:0000381","count":14},{"id":"GO:1905663","count":13}]},{"hash":"1952773136728195167","title":"B cell activation and antibody production","description":"The cluster is dominated by B cell\u2013related functions: B cell receptor signaling, positive regulation of B cell activation, and immunoglobulin production, along with accompanying processes like complement activation and phagocytosis that bridge adaptive and innate immunity. Cell adhesion terms suggest immune cell interactions and synapse formation. Together these points strongly indicate a humoral/antibody-focused immune cluster.","confidence":"High","size":23,"edges":18,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:2000649","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0006958","count":6}]},{"hash":"2195628824131602898","title":"Innate inflammatory cytokine production","description":"This cluster is dominated by GO terms for inflammatory and innate immune processes, including inflammatory response, innate immune response, production of IL-1\u03b2 and IL-18, and regulation of IL-1\u03b2 production, plus connections to NF-kB signaling and ubiquitination. A few terms about mitotic spindle assembly are less central, but the core theme across proteins appears to be innate immune cytokine production and inflammatory signaling. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090307","count":13},{"id":"GO:0006954","count":12},{"id":"GO:0032621","count":11},{"id":"GO:0032611","count":11},{"id":"GO:0016567","count":11}]},{"hash":"1568469721806113966","title":"Rac/GTPase signaling and development","description":"The cluster is enriched for GO terms on GTPase activity, Rac signal transduction, and cytoskeletal dynamics (microtubule-based movement), plus developmental processes (spinal cord and heart development). Immune signaling terms (B cell receptor signaling, GM-CSF response) and prostaglandin responses suggest broader signaling roles, but the common thread appears to be GTPase-driven signaling that governs cytoskeletal behavior with links to development and immune signaling. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0071333","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0071380","count":3}]},{"hash":"203845235503940992","title":"Proteolysis and Coagulation Regulation","description":"The terms center on proteolytic processes and coagulation/fibrinolysis (blood coagulation, fibrinolysis, regulation of plasminogen activation, and digestion), with related peptide/protein processing (insulin processing, protein autoprocessing) and some ECM remodeling. This suggests a cohesive theme around protease-driven processing events that regulate coagulation, fibrinolysis, and peptide maturation. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0042730","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0007586","count":4},{"id":"GO:0071333","count":4}]},{"hash":"2105448909953296621","title":"Mitochondrial Complex IV Assembly and Inner Membrane Insertion","description":"This cluster strongly centers on mitochondrial respiratory chain assembly, especially complex IV, and on proteins involved in insertion into the inner mitochondrial membrane and proton translocation. Additional terms hint at metal stress responses, but the core signal is assembly and membrane integration of respiratory chain components.","confidence":"High","size":23,"edges":30,"triangles":25,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":6},{"id":"GO:1902600","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0042774","count":3},{"id":"GO:0051291","count":2}]},{"hash":"1744422851475074850","title":"Ribosome biogenesis and rRNA maturation","description":"The cluster is enriched for translation and ribosome biogenesis terms, with multiple specific rRNA maturation steps (SSU/LSU/5.8S) and snoRNP assembly, plus pseudouridine synthesis. These converge on ribosome production and rRNA processing, suggesting proteins involved in ribosome assembly rather than other pathways.","confidence":"High","size":23,"edges":252,"triangles":1750,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":17},{"id":"GO:0042254","count":9},{"id":"GO:0000462","count":6},{"id":"GO:0007338","count":5},{"id":"GO:0031118","count":4}]},{"hash":"799629400104786424","title":"Actin Remodeling and Endocytosis in Immune Signaling","description":"These proteins highly represent actin cytoskeleton remodeling and endocytic processes (actin branching, ruffle and podosome assembly, endocytosis, phagocytic engulfment) and are linked to signaling at immune cell contacts (TCR, ephrin) and synaptic interfaces. The common theme is actin-driven membrane dynamics coordinating signaling at cell\u2013cell contacts.","confidence":"High","size":23,"edges":87,"triangles":118,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090135","count":19},{"id":"GO:0006897","count":19},{"id":"GO:0048013","count":19},{"id":"GO:0050852","count":19},{"id":"GO:0071803","count":19}]},{"hash":"10094845922350748","title":"Nuclear transport and ribosome biogenesis","description":"The top GO terms point to exporting ribosomal subunits and mRNA from the nucleus, ribosome biogenesis, and nuclear pore complex assembly, plus import of NLS-bearing proteins, indicating a cluster centered on nuclear transport and ribosome assembly with related nuclear functions such as transcription regulation and kinetochore association.","confidence":"High","size":23,"edges":213,"triangles":1090,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000055","count":6},{"id":"GO:0006406","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0042254","count":5},{"id":"GO:0000122","count":5}]},{"hash":"1642243200162074370","title":"Mitochondrial Transporters and Energy Regulation","description":"These proteins are dominated by transmembrane transport of several metabolites (glycine, NAD, thiamine pyrophosphate, citrate, thiosulfate) and features related to mitochondrial dynamics (membrane fission) and energy balance, including adaptive thermogenesis and insulin/IGF-related signaling. The common thread is mitochondrial transport/metabolism linked to insulin signaling and energy homeostasis.","confidence":"High","size":23,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0036233","count":16},{"id":"GO:0090149","count":16},{"id":"GO:0035352","count":16},{"id":"GO:0030974","count":16},{"id":"GO:1990845","count":16}]},{"hash":"13564595988195594","title":"Calcium signaling, vesicle trafficking, and cytoskeletal regulation","description":"Dominant terms point to calcium release into the cytosol, regulation of SNARE complex assembly, and actin/cytoskeletal dynamics, which are key for vesicle trafficking and exocytosis. Additional terms like protein ubiquitination and cell cycle indicate general cellular regulation, while oligodendrocyte differentiation and cell adhesion hint at neural/glial development and cell\u2013cell interactions. Overall, the cluster appears to reflect intracellular signaling coordinating vesicle fusion with cytoskeletal remodeling, with possible relevance to glial differentiation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0048709","count":3},{"id":"GO:0051209","count":3},{"id":"GO:0007049","count":3},{"id":"GO:2001275","count":3}]},{"hash":"1604356156677514532","title":"Rho GTPase\u2013driven actin remodeling and adhesion signaling","description":"This cluster centers on actin cytoskeleton dynamics (filopodium and podosome assembly, stress fiber formation, actin branching) and small GTPase\u2013mediated signaling, which together regulate cell spreading and endocytosis. The presence of adhesion- and ephrin-related signaling terms suggests coordination between cytoskeletal remodeling and cell\u2013cell or cell\u2013matrix contacts, while endocytosis ties in membrane trafficking. Overall, the proteins likely form a module governing actin remodeling linked to adhesion and signaling pathways.","confidence":"High","size":23,"edges":5,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046847","count":13},{"id":"GO:1900026","count":12},{"id":"GO:0071803","count":11},{"id":"GO:0007264","count":11},{"id":"GO:0043552","count":11}]},{"hash":"103525799257403537","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":208,"triangles":1045,"max_degree":22,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045008","count":6},{"id":"GO:0006289","count":6},{"id":"GO:0009416","count":6},{"id":"GO:1901291","count":6},{"id":"GO:1902800","count":6}]},{"hash":"1756819927578783891","title":"Embryonic organogenesis and neural development","description":"The proteins are enriched for diverse developmental processes across several tissues (retina, pituitary, pancreas, cortex, cranial/skull, digestive tract, bone), with neuron differentiation and neural regulation of physiology also prominent. This suggests a coherent theme of embryonic patterning and organ formation, particularly involving neural development and cross-tissue differentiation programs, rather than a single tissue-specific function. Therefore, a label reflecting embryonic organogenesis and neural development is appropriate and representative.","confidence":"High","size":23,"edges":205,"triangles":973,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":13},{"id":"GO:0021983","count":12},{"id":"GO:0006366","count":12},{"id":"GO:0002087","count":12},{"id":"GO:0002076","count":12}]},{"hash":"1694150280071255446","title":"Neuronal development and synaptic signaling","description":"The cluster is enriched for GO terms related to nervous system development, excitatory postsynaptic potentials, and regulation of synaptic vesicle exocytosis, with associated signaling pathways such as ERK/MAPK and Ras. This suggests a cohesive theme centered on neuronal signaling and synaptic function, even though a few terms pertain to other tissues; the neural-related terms dominate the top terms and provide a coherent label.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0031532","count":4}]},{"hash":"2059500389526603117","title":"Wnt-Hippo signaling and apoptosis regulation","description":"The cluster is dominated by canonical Wnt signaling and Hippo signaling terms, plus developmental/differentiation processes (paraxial mesoderm development, keratinocyte differentiation) and apoptosis-related terms, suggesting these proteins jointly regulate developmental signaling pathways that govern cell proliferation, differentiation, and survival.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090263","count":18},{"id":"GO:0060044","count":17},{"id":"GO:0006915","count":17},{"id":"GO:0035329","count":17},{"id":"GO:0030216","count":17}]},{"hash":"1033950327760047401","title":"Developmental cell proliferation and ribosome biogenesis","description":"This cluster combines signals of developmental programs (multicellular organism development, skin development) with core biosynthetic and cell-cycle activities (cell division, ribosome biogenesis, mRNA transport, RNA methylation, and protein oligomerization/heterotrimerization), suggesting proteins that support proliferative growth and protein synthesis during tissue development.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0051260","count":7},{"id":"GO:0000747","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0036265","count":6}]},{"hash":"1378354854818426218","title":"Dopaminergic GPCR signaling regulation","description":"The strongest signals cluster around dopamine signaling and GPCR-cAMP regulation, notably negative regulation of dopamine receptor signaling, dopamine transport, and adenylate cyclase-inhibiting GPCR signaling. This suggests the proteins act together to modulate dopamine-driven GPCR pathways, with a few outlier terms reflecting broader annotations.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":23},{"id":"GO:0090075","count":23},{"id":"GO:0007194","count":23},{"id":"GO:0016998","count":23},{"id":"GO:0040015","count":23}]},{"hash":"1673059420127957881","title":"GPCR-Gs-cAMP signaling in autonomic outputs","description":"This cluster centers on GPCR signaling that activates adenylate cyclase and modulates cAMP levels (GO:0007190, GO:0010579), tying to autonomic-regulated functions like saliva secretion (GO:0046541) and vascular/airway smooth muscle relaxation (GO:0090075, GO:0045777, GO:0060160). While a few terms touch on metabolism or growth, the strongest signals point to GPCR-mediated cAMP pathways governing secretory and smooth muscle/vascular responses, consistent with autonomic control. ","confidence":"Medium","size":23,"edges":86,"triangles":27,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0046541","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0022900","count":18}]},{"hash":"1255491060628421853","title":"Androgen-regulated prostate development and cell division","description":"This cluster shows strong enrichment for male sex differentiation, prostate gland development, and steroid hormone receptor complex assembly, pointing to androgen signaling in prostate biology. The presence of cell division terms like cell division and metaphase/anaphase transition suggests coordination with mitosis in proliferative prostate tissue. Some outlier terms (photoreceptor outer segment localization, histone methylation) may reflect multi-functional proteins or annotation noise, but the core theme is androgen-driven prostate development linked to cell-cycle regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046661","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0006463","count":8},{"id":"GO:0030850","count":8},{"id":"GO:0007091","count":7}]},{"hash":"2002143478822335604","title":"Unknown","description":"The top GO terms span energy metabolism (aerobic respiration, proton transport), proteostasis (ubiquitin recycling, proteolysis regulation), signaling/aging (insulin signaling, lifespan determination), protein assembly, and even viral processes, with no clear shared function. With only a single edge and disparate themes, there isn\u2019t a cohesive label that accurately represents the cluster.","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":2},{"id":"GO:0071432","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0010992","count":2},{"id":"GO:0008286","count":2}]},{"hash":"1004464387549646741","title":"Embryonic development and organogenesis","description":"These proteins are enriched for developmental and morphogenetic GO terms across multiple tissues (type B pancreatic cell development, trophoblast giant cell differentiation, hair follicle morphogenesis, left/right pattern formation, cartilage morphogenesis, EMT in endocardial cushion formation, endocrine system development), indicating a role in embryonic development and organogenesis. Some nucleic acid processing terms appear (mRNA splicing, ribosomal large subunit export) but do not override the overarching developmental theme.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":5},{"id":"GO:0060707","count":4},{"id":"GO:0031069","count":4},{"id":"GO:0000055","count":4},{"id":"GO:0060972","count":4}]},{"hash":"845926048365954158","title":"Cerebellar development and Bergmann glia differentiation","description":"The top terms strongly point to cerebellar development and Bergmann glial differentiation (Bergmann glial cell differentiation and cerebellar cortex formation both with high counts), supported by related neural development and axon regeneration regulation terms. While insulin signaling and T cell receptor signaling appear, the cerebellar-specific terms dominate, suggesting a cluster centered on cerebellar development and Bergmann glia biology.","confidence":"High","size":23,"edges":231,"triangles":1352,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060020","count":22},{"id":"GO:0021697","count":22},{"id":"GO:0048679","count":22},{"id":"GO:0008285","count":22},{"id":"GO:0008286","count":22}]},{"hash":"335463049273981588","title":"Growth and metabolic regulation","description":"The set includes GO terms spanning proliferation regulation, metabolism (glycogen and chlorophyll catabolism), proteolysis, hormone response (glucocorticoid, insulin secretion), and cell remodeling (adhesion, endothelial migration). While diverse, the common theme is regulation of growth-related and metabolic processes and their signaling, so a broad label like \"Growth and metabolic regulation\" best captures the cluster without implying a single pathway. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008284","count":5},{"id":"GO:0005980","count":5},{"id":"GO:0006508","count":4},{"id":"GO:0051384","count":4},{"id":"GO:0043542","count":3}]},{"hash":"1705433481727116445","title":"Developmental transcriptional regulation and organogenesis","description":"Top GO terms indicate broad transcriptional control by RNA polymerase II (including negative regulation) coupled with diverse organ development processes across multiple tissues (neural, eye, pituitary, pancreas, digestive tract, lung). This suggests a core set of transcriptional regulators coordinating development across organs, rather than a tissue-specific function. ","confidence":"High","size":23,"edges":140,"triangles":324,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0021983","count":11},{"id":"GO:0000122","count":10},{"id":"GO:0071542","count":10},{"id":"GO:0048565","count":10}]},{"hash":"29222723763508809","title":"Golgi vesicle trafficking and Rho GTPase regulation","description":"This cluster is dominated by processes related to intracellular transport and vesicle fusion, including trafficking to and from the Golgi, with several terms indicating regulation of GTPase activity and Rho signaling. While innate immune terms appear, the strongest signals point to Golgi-associated vesicle dynamics and cytoskeletal regulation as the unifying theme.","confidence":"High","size":23,"edges":6,"triangles":1,"max_degree":2,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":6},{"id":"GO:0051301","count":4},{"id":"GO:0048280","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006906","count":4}]},{"hash":"1785222957236895988","title":"Neuronal polarity, trafficking, and ERK signaling","description":"The top GO terms point to membrane trafficking (plasma membrane to endosome), apical localization, actin cytoskeleton polarity, and ERK signaling, with brain development as a readout. This combination fits a theme of polarity-driven vesicular transport and signal transduction in neurons, where ERK cascades modulate growth and differentiation. ER stress and GTPase regulation are ancillary but compatible within this polarity-signaling network.","confidence":"Medium","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048227","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0034976","count":3},{"id":"GO:0034260","count":3},{"id":"GO:0033138","count":3}]},{"hash":"1178358281896175619","title":"Neuroimmune development and myelination","description":"The cluster combines strong signals of innate immune activity (innate immune response, defense against Gram-positive bacteria, dsRNA/LPS responses, interferon-beta production) with neural development processes (synapse assembly, myelination, axonal fasciculation). This suggests proteins that bridge immune sensing and nervous system maturation, possibly reflecting microglial or glial roles in shaping neural connectivity and myelin formation.","confidence":"Medium","size":23,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":11},{"id":"GO:0050830","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0042552","count":10},{"id":"GO:0007413","count":9}]},{"hash":"643137494417429601","title":"Actin Cytoskeleton Remodeling and Cell Adhesion","description":"The cluster is dominated by terms tied to actin dynamics: stress fiber assembly, filopodium formation, Rac signaling, and cellular responses to mechanical stimuli and substrate-dependent spreading. These reflect actin-driven remodeling linked to adhesion and motility, with some peripheral terms like mitotic spindle assembly and endosome transport being less central. This cohesive theme supports labeling as actin cytoskeleton remodeling with adhesion-related functions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":6},{"id":"GO:0090307","count":6},{"id":"GO:0045022","count":5},{"id":"GO:0016601","count":5},{"id":"GO:0071260","count":5}]},{"hash":"611081993582690143","title":"Endomembrane trafficking and Golgi organization","description":"The top GO terms are dominated by endosome organization, Golgi organization, and various protein transport terms, especially intra-Golgi vesicle transport. This points to a cohesive theme of vesicle trafficking within the secretory pathway, which best explains the cluster\u2019s shared function. Other terms (e.g., locomotion, adaptive immune response) may reflect pleiotropy or annotation noise but are not central to the core activity. Therefore, the label focusing on intracellular vesicle transport and Golgi/endosome organization is most representative.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007032","count":3},{"id":"GO:0007030","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0006891","count":2},{"id":"GO:0008344","count":2}]},{"hash":"472051554513048155","title":"Ciliary Axoneme Assembly and Motility","description":"The cluster is dominated by GO terms tied to cilia and flagella function: sperm axoneme assembly, flagellated sperm motility, and cilium movement in epithelial tissue, including regulation of cilium movement. Tubulin post-translational modifications (polyglycylation, polyglutamylation) and microtubule severing further point to microtubule-based axoneme machinery. Some terms (DNA-templated transcription, Wnt signaling) appear incidental, but the core signal reflects cilium/axoneme assembly and motility.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007288","count":2},{"id":"GO:1905419","count":2},{"id":"GO:0003351","count":2},{"id":"GO:0003353","count":2},{"id":"GO:0018094","count":2}]},{"hash":"1556244025991304650","title":"Neural crest-driven craniofacial and sensory development","description":"This cluster heavily features terms tied to neural crest derivatives and craniofacial and sensory structures: peripheral nervous system neuron development, glial cell differentiation, inner ear development, cartilage and cranial skeleton morphogenesis, and even midbrain development and primitive streak formation indicating early developmental processes. The common theme is neural crest\u2013mediated formation of craniofacial skeleton and sensory organs, along with associated neural development.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":7},{"id":"GO:0090009","count":7},{"id":"GO:0048935","count":7},{"id":"GO:0007601","count":7}]},{"hash":"750594008165638420","title":"Ubiquitin-Dependent Immune Regulation","description":"The cluster is dominated by GO terms tied to ubiquitin-dependent protein catabolic process, indicating proteolysis via ubiquitin pathways that regulate signaling. Several terms strongly point to adaptive immunity and development (B cell receptor signaling, germinal center formation, dendritic cell differentiation, pro-T cell differentiation, isotype switching), suggesting a cohesive module of ubiquitin-mediated regulation of immune signaling and differentiation. A few unrelated terms (tubule morphogenesis, renal function, muscle development) may reflect broader annotations or misannotations, but the dominant signal supports an immune-centric, ubiquitin-dependent regulatory function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0050853","count":7},{"id":"GO:0002467","count":6},{"id":"GO:2001200","count":6},{"id":"GO:1900477","count":6}]},{"hash":"425564024047008046","title":"RNA Pol II Transcription Regulation","description":"This cluster is dominated by GO terms tied to transcription by RNA polymerase II, including DNA-templated transcription and preinitiation complex assembly, indicating a shared role in transcription initiation and gene expression control. A few miscellaneous terms (histidine catabolism, folate interconversion, proteoglycan biosynthesis, neuroblast proliferation) are present but appear incidental rather than defining. Overall, the core theme is transcription regulation by RNA Pol II.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:2000009","count":2},{"id":"GO:0006357","count":1},{"id":"GO:0032147","count":1},{"id":"GO:0051123","count":1}]},{"hash":"135811634443109064","title":"Sensory organ and CNS development","description":"This cluster centers on developmental processes for sensory organs (antennae, compound eye) and the central nervous system, with related segmentation. Signaling and stress-related terms appear as regulatory or contextual components, but the dominant theme is sensory/neuronal development.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":2},{"id":"GO:0038203","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0090630","count":2}]},{"hash":"306515907825195973","title":"Neural Synaptic Transmission and Plasticity","description":"The list centers on synaptic activity and plasticity in neurons: neurotransmitter secretion, chemical synaptic transmission, excitatory postsynaptic potentials, and long-term synaptic depression, plus dendritic spine morphogenesis and synapse structural regulation. Behavioral GO terms like vocalization and social behavior point to neural circuit\u2013level consequences. The lens morphogenesis term is likely an annotation artifact.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070309","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0051835","count":3},{"id":"GO:2000463","count":3},{"id":"GO:0060292","count":3}]},{"hash":"201087127619838518","title":"Cardiac signaling and energy metabolism","description":"The top GO terms point to heart-related processes (outflow tract morphogenesis, Purkinje-to-ventricular signaling, calcium release in muscle), along with metabolic regulation (insulin signaling, fatty acid oxidation) and mitochondrial machinery, suggesting a cohesive theme around cardiac development/function supported by energy metabolism. Some terms are more general (e.g., startle response, apoptosis), but the cardiac-focused terms dominate the cluster\u2019s functional signal. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":3},{"id":"GO:0061668","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0046320","count":3},{"id":"GO:0006915","count":3}]},{"hash":"878941355569961379","title":"Embryonic Development and Cell Polarity","description":"We see terms tied to developmental patterning (skin development, cartilage condensation) and subcellular localization (bicoid/oskar mRNA localization, axial bud site selection), plus general transport and signaling processes. The cluster appears to group proteins involved in developmental organization and polarity rather than a single cohesive pathway, justifying a label around embryonic development and cell polarity.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071603","count":5},{"id":"GO:0010754","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0001502","count":5},{"id":"GO:0045450","count":4}]},{"hash":"1494017069129643203","title":"Dopaminergic GPCR Signaling Regulation","description":"Most terms point to negative regulation of dopamine receptor signaling, negative regulation of adenylate cyclase activity, and dopamine transport, suggesting a cluster focused on modulation of dopaminergic GPCR pathways. Some terms (cell wall macromolecule catabolic process, thymocyte differentiation) appear tangential or due to broader/contaminant annotations, but the dominant theme is dopaminergic signaling regulation and GPCR-associated signaling.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":23},{"id":"GO:0090075","count":23},{"id":"GO:0007194","count":23},{"id":"GO:0016998","count":23},{"id":"GO:0040015","count":23}]},{"hash":"379400508189898615","title":"Dopaminergic signaling regulation","description":"The proteins are enriched for terms tied to dopamine pathway control (negative regulation of dopamine receptor signaling, dopamine transport) and GPCR-adenylate-cyclase signaling, pointing to a shared function in modulating dopaminergic neurotransmission in the CNS; additional neural development terms may reflect broader brain-associated roles.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":23},{"id":"GO:0090075","count":23},{"id":"GO:0007194","count":23},{"id":"GO:0016998","count":23},{"id":"GO:0040015","count":23}]},{"hash":"799662007480421666","title":"Dopaminergic Signaling and Sensory Perception","description":"The cluster\u2019s top GO terms center on neural signaling and sensory processes: dopaminergic synaptic transmission, visual perception and learning, pain perception, and behavioral responses to cocaine, all pointing to dopamine-related neural circuitry and sensory processing. ERK1/2 cascade regulation and prostaglandin-related responses further tie into signaling dynamics in nervous tissue and behavior. Although there are some peripheral terms (heart development, macrophage chemotaxis), the dominant theme is nervous system signaling and sensory experience, especially dopaminergic pathways and reward-related behavior.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":22},{"id":"GO:0007507","count":22},{"id":"GO:0019233","count":22},{"id":"GO:0008542","count":22},{"id":"GO:0001963","count":22}]},{"hash":"660364623811940703","title":"Development and cytoskeletal organization","description":"The top GO terms cluster around developmental processes (multicellular development, lens fiber cell differentiation) and cell cycle/cell division with centrosome localization, plus cytoskeletal regulation (barbed-end actin filament capping) and chromatin modification (histone H3 acetylation). Immunological synapse formation also points to cell\u2013cell interaction contexts. The mix suggests a broad developmental/architectural role rather than a single pathway, justifying a label focused on development and cytoskeletal organization.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043966","count":4},{"id":"GO:0006349","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0051301","count":4}]},{"hash":"1175602257796630858","title":"Unknown","description":"The terms cluster around collagen fibril organization (ECM) and immune/LPS-related defense signals, but also include axonogenesis and meiotic processes, offering no single coherent function tying all proteins together; hence Unknown with None.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":7},{"id":"GO:0071222","count":6},{"id":"GO:0032722","count":6},{"id":"GO:0050829","count":6},{"id":"GO:0031663","count":6}]},{"hash":"2150174157185753148","title":"Gustatory chemosensation and sensory development","description":"The cluster is dominated by GO terms for sensory perception of chemical stimuli, especially taste and bitter taste, pointing to chemosensory detection. Related terms about sensory organ development (skin, retina) suggest a broader theme of sensory biology, with additional signals like pheromone and LPS responses indicating chemical signal responsiveness. This makes a concise label around gustatory chemosensation and sensory development representative of the group.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050909","count":7},{"id":"GO:0001580","count":5},{"id":"GO:0007338","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0007606","count":4}]},{"hash":"135756974136063539","title":"Immune signaling and tissue morphogenesis","description":"The cluster is enriched for immune-related signaling terms (stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, phagocytosis recognition, regulation of NK cell chemotaxis) indicating innate/immune communication. It also includes several morphogenesis terms (lymph vessel, metanephric tubule, cartilage condensation), suggesting a link to tissue development/remodeling. This combination points to proteins involved in immune signaling with roles in tissue morphogenesis.","confidence":"Medium","size":22,"edges":225,"triangles":1431,"max_degree":21,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:2000502","count":18},{"id":"GO:0071226","count":15},{"id":"GO:0001502","count":13},{"id":"GO:0006910","count":13},{"id":"GO:0051873","count":12}]},{"hash":"665660250407059173","title":"Immune modulation and cytotoxic activity regulation","description":"The cluster is dominated by immune-related processes: positive regulation of dendritic cell differentiation; positive regulation of monocyte chemotactic protein-1 production; and negative regulation of NK cell\u2013mediated cytotoxicity and cytotoxic T cell degranulation, indicating modulation of immune cell activation and effector functions. It also includes regulation of actin cytoskeleton organization by cell\u2013cell adhesion, supporting controlled cell interactions, and a note on symbiont entry into host cells, pointing to host\u2013pathogen interaction contexts. A couple of terms (adult chitin-based cuticle pattern formation, obsolete receptor activity) are less consistent with the main theme, likely annotation noise, but do not override the overall immune-centric signal.","confidence":"Medium","size":22,"edges":186,"triangles":902,"max_degree":21,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001200","count":21},{"id":"GO:1904597","count":21},{"id":"GO:0071639","count":21},{"id":"GO:0035018","count":21},{"id":"GO:1904604","count":21}]},{"hash":"2240410366104307608","title":"Innate Immunity and Inflammatory Response","description":"Most terms point to innate immunity and inflammation (innate immune response, complement activation, defense against Gram-positive bacteria, macrophage/dendritic cell regulation, and MCP-1 production). This suggests the cluster comprises proteins involved in immune defense and inflammatory signaling. A couple terms (retina homeostasis and chitin-based cuticle pattern formation) may be incidental or reflect broader organism-specific annotations rather than core function.","confidence":"High","size":22,"edges":46,"triangles":37,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":11},{"id":"GO:1904597","count":11},{"id":"GO:0071639","count":11},{"id":"GO:1904604","count":11},{"id":"GO:0006958","count":11}]},{"hash":"2293280559586271843","title":"Rho/Rac-driven cytoskeletal remodeling","description":"The cluster centers on Rac and Rho signaling and cytoskeletal assembly (filopodium and microvillus), indicating coordinated actin-based remodeling. Additional terms for cAMP signaling, xenobiotic/heat responses, and protein ubiquitination/proteolysis suggest regulatory and stress-response layers that modulate cytoskeletal dynamics. Together, these terms point to a module of proteins involved in Rho/Rac\u2011mediated cytoskeleton remodeling and associated signaling. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0009408","count":5},{"id":"GO:0030033","count":4},{"id":"GO:0016601","count":4},{"id":"GO:0071320","count":4}]},{"hash":"1637343665814195419","title":"Ribosome biogenesis and translation during cell cycle","description":"This cluster is dominated by GO terms for ribosome assembly, translation initiation and reinitiation, and tRNA transcription, pointing to a core role in protein synthesis machinery. The concurrent cell cycle and DNA replication terms suggest these translation/biogenesis processes are coordinated with cell proliferation.","confidence":"High","size":22,"edges":216,"triangles":1271,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001731","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0002188","count":5},{"id":"GO:0043547","count":3},{"id":"GO:0001732","count":3}]},{"hash":"1882769910365392072","title":"Biosynthesis and cell-cycle regulation","description":"This cluster is enriched for biosynthetic processes (transsulfuration, hydrogen sulfide biosynthesis, GTP and fatty acid biosynthesis, homocysteine catabolism) along with cell-cycle related terms (regulation of mitotic metaphase/anaphase transition) and nuclear import, suggesting a group of proteins involved in building cellular components and coordinating division, with an additional signaling regulation aspect (negative regulation of TGF-\u03b2 signaling).  ","confidence":"Medium","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0030512","count":10},{"id":"GO:0019346","count":9},{"id":"GO:0006183","count":9},{"id":"GO:0070814","count":9},{"id":"GO:0030071","count":9}]},{"hash":"1341811028409253142","title":"Ribosome Biogenesis and Translation","description":"The top GO terms cluster around ribosome-associated processes: cytoplasmic translation, ribosome biogenesis, ribosomal subunit export from the nucleus, and tRNA modification, indicating proteins involved in ribosome assembly and protein synthesis. While there are a few stress-response terms, the dominant theme is ribosome formation and function, justifying a label focused on ribosome biogenesis and translation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":5},{"id":"GO:0042254","count":5},{"id":"GO:1901001","count":4},{"id":"GO:1903833","count":4},{"id":"GO:0006400","count":4}]},{"hash":"1402326019978987937","title":"UV-induced DNA Repair and Transcription Regulation","description":"The cluster\u2019s top GO terms center on nucleotide-excision repair, especially transcription-coupled repair, and responses to UV light (UV-B/UV-C), indicating a core function in repairing UV-induced DNA damage and coordinating transcriptional responses. Additional terms about transcription regulation and cell cycle suggest a broader DNA-damage response role that interfaces with gene expression and cell-cycle control.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901666","count":4},{"id":"GO:0071157","count":4},{"id":"GO:0000720","count":4},{"id":"GO:0061178","count":4},{"id":"GO:0040034","count":4}]},{"hash":"653205341251254920","title":"TLR/LPS-driven inflammatory signaling","description":"This cluster is strongly enriched for innate immune sensing and inflammatory signaling terms: cellular response to lipopolysaccharide, detection of bacterial lipopeptide, and toll-like receptor 8 signaling pathway, along with positive regulation of NLRP3 inflammasome complex assembly. Negative regulation of protein kinase activity and chemokine signaling also fit within the broader theme of regulating inflammatory responses, while a couple of outlier terms (e.g., floral organ specification) may reflect cross-annotation noise. Overall, the proteins appear linked to TLR/NLRP3-mediated inflammatory responses to bacterial components.","confidence":"High","size":22,"edges":58,"triangles":63,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016525","count":14},{"id":"GO:0006469","count":14},{"id":"GO:0050729","count":13},{"id":"GO:0071222","count":13},{"id":"GO:0070340","count":12}]},{"hash":"1064871952520080480","title":"Tight Junction Assembly and Actin Remodeling","description":"This cluster centers on bicellular tight junction formation together with extensive actin cytoskeleton remodeling (actin branching, ruffle and podosome assembly) and polarity maintenance that shapes cell form, plus associated endocytosis and small GTPase signaling and ephrin signaling. The recurring themes point to coordinated epithelial barrier establishment and dynamic cytoskeletal regulation of membrane trafficking and cell shape. ","confidence":"High","size":22,"edges":17,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070830","count":9},{"id":"GO:0090135","count":8},{"id":"GO:0071803","count":8},{"id":"GO:0034260","count":8},{"id":"GO:0071963","count":8}]},{"hash":"1603130557786416718","title":"Unknown","description":"The GO terms span synapse localization, telomere maintenance, GPCR signaling, barrier formation, Rac signaling regulation, epithelial polarity, cell migration, and skeletal development with no clear dominant function, making a cohesive label unreliable.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035418","count":3},{"id":"GO:1904355","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0090557","count":3},{"id":"GO:0035021","count":3}]},{"hash":"144794054945276542","title":"Post-transcriptional RNA regulation and translation initiation","description":"This cluster is enriched for multiple aspects of RNA metabolism and control of translation, including mRNA stability and modification, splicing regulation via the spliceosome, ncRNA-mediated gene silencing, and assembly/activation of translation initiation complexes, suggesting coordinated post-transcriptional regulation of gene expression, particularly under stress.","confidence":"High","size":22,"edges":57,"triangles":145,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0048025","count":9},{"id":"GO:0031047","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0002188","count":9}]},{"hash":"436598159870604523","title":"Spliceosome-Mediated mRNA Processing","description":"The cluster shows strong enrichment for splicing- and mRNA processing-related GO terms (spliceosome-mediated splicing, regulation of alternative splicing, mRNA modification, stability), plus ncRNA-mediated gene silencing and translation initiation connections, indicating a cohesive post-transcriptional regulatory module centered on RNA processing and splicing.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":15},{"id":"GO:0010610","count":15},{"id":"GO:0031047","count":15},{"id":"GO:0000381","count":12},{"id":"GO:0045292","count":11}]},{"hash":"1073535408767801797","title":"ER-Golgi Vesicle Trafficking Regulators","description":"The strongest recurring themes are ER\u2013Golgi vesicle transport (ER to Golgi and Golgi to ER) and positive regulation of GTPase activity, which together point to proteins involved in vesicle trafficking and membrane dynamics; other terms like transcription or neural development may reflect broader multifunctionality rather than a core cluster signal.","confidence":"Medium","size":22,"edges":8,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006890","count":5}]},{"hash":"420714088382489729","title":"Clathrin-mediated endocytosis","description":"The top GO terms point to vesicle trafficking and clathrin-dependent uptake\u2014intracellular protein transport, synaptic vesicle coating, and clathrin-dependent endocytosis\u2014suggesting a shared role in vesicle formation and endocytosis. Some terms appear incidental, but the dominant pattern supports clathrin-mediated endocytosis as the cluster\u2019s core function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0016183","count":3},{"id":"GO:0072583","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0003014","count":1}]},{"hash":"1321112750393161884","title":"Developmental Signaling Regulation","description":"The cluster\u2019s top GO terms point to broad control of key developmental signaling pathways (BMP, Wnt, PI3K/AKT, activin) and processes such as CNS development, germ-line stem cell division, and angiogenesis. This points to proteins that regulate, rather than execute, developmental signaling programs across different contexts. Hence a concise label capturing \u201cdevelopmental signaling regulation\u201d seems most representative.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":4},{"id":"GO:0048147","count":3},{"id":"GO:0048132","count":3},{"id":"GO:1905453","count":3},{"id":"GO:0007084","count":3}]},{"hash":"230805330322423732","title":"Rho GTPase signaling and exocytic vesicle fusion","description":"The cluster is characterized by enrichment in Rho protein signal transduction and regulation of GTPase activity, plus processes tied to exocytosis such as vesicle fusion and calcium ion\u2013dependent exocytosis. While development-related terms (heart, nervous system, skeletal) suggest broader multicellular roles, the common thread appears to be Rho GTPase\u2013driven signaling linked to vesicle trafficking and membrane fusion, which justifies this label.","confidence":"Medium","size":22,"edges":196,"triangles":950,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007507","count":13},{"id":"GO:0007399","count":12},{"id":"GO:0007124","count":12},{"id":"GO:0007266","count":12},{"id":"GO:0043547","count":12}]},{"hash":"1076117032943932053","title":"Neurodevelopment and growth regulation","description":"This cluster\u2019s top GO terms point to neural development (e.g., ventral spinal cord interneuron specification, midbrain dopaminergic neuron differentiation) alongside broader developmental and growth-control processes (anterior head development, nephron and uterine development, regulation of hepatocyte proliferation, hippo signaling). The combination suggests proteins involved in developmental patterning and growth signaling rather than a single metabolic or direct pathway, so a label capturing both neurodevelopment and growth regulation fits best.","confidence":"Medium","size":22,"edges":36,"triangles":17,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0035331","count":21},{"id":"GO:0035847","count":21},{"id":"GO:2000346","count":21},{"id":"GO:0019417","count":21},{"id":"GO:2000744","count":21}]},{"hash":"1787584217019021978","title":"RNA processing and splicing machinery","description":"The cluster is dominated by GO terms for mRNA processing, spliceosomal complex assembly, and transcription-related chromatin remodeling, indicating a core function in RNA maturation and gene expression regulation; other terms (TORC1 signaling, chromatin remodeling) may reflect broader cellular processes or noise.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051262","count":2},{"id":"GO:0038202","count":2},{"id":"GO:0051306","count":2},{"id":"GO:0000245","count":2},{"id":"GO:0006397","count":2}]},{"hash":"829129722007090539","title":"Teichoic acid and cell wall glycan biosynthesis","description":"The terms cluster around teichoic acid biosynthesis, cell wall organization, and various glycosylation and sugar-metabolism processes (UDP-glucose/UDP-galactose, N-acetyl-galactosamine), with references to O-linked glycosylation and polysaccharide biosynthesis such as hyaluronan. This suggests a cohesive theme of Gram-positive bacterial cell wall assembly and glycan modification, centered on teichoic acid and related glycan pathways.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0019350","count":5},{"id":"GO:0006281","count":4},{"id":"GO:0016266","count":3},{"id":"GO:0052573","count":3},{"id":"GO:0071555","count":3}]},{"hash":"1878511101094417467","title":"Growth and survival signaling","description":"This cluster is enriched for GO terms centered on anti-apoptosis, PI3K/AKT signaling, TORC1 signaling, endothelial proliferation, and related growth-regulatory processes, pointing to a general theme of cell survival and growth signaling. There are additional, more diverse terms (lipopolysaccharide signaling, ruffle organization, keratinization, visual learning, transcription regulation, mitotic cycle) that suggest broader regulatory roles and context-specific functions, but the core pattern emphasizes signaling pathways that promote cell growth and survival. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0001938","count":2},{"id":"GO:0038202","count":2}]},{"hash":"640708641205279255","title":"Steroidogenesis and synapse localization","description":"This cluster is driven by testosterone biosynthetic process and androgen metabolic process, pointing to steroid hormone production. The presence of terms related to protein localization to the synapse and immunological synapse formation suggests associated synaptic signaling/localization roles, with phosphorylation and CoA biosynthesis reflecting the broader metabolic context supporting hormone biosynthesis. The combination implies a theme around steroid production coupled with synaptic localization, though some terms are peripheral to this core function.","confidence":"Medium","size":22,"edges":50,"triangles":12,"max_degree":11,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0016310","count":7},{"id":"GO:0061370","count":4},{"id":"GO:0008209","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0015937","count":4}]},{"hash":"1920467071779275203","title":"Metabolic Biosynthesis and Degradation","description":"The proteins are linked to a range of metabolism-related GO terms, spanning biosynthetic processes (antibiotic, biotin, PHB) and catabolic/degradative processes (triglyceride and phospholipid turnover, chlorophyll degradation), along with related themes like nitrogen utilization and detoxification. This suggests a broad metabolic role rather than a single specific pathway, hence a general label capturing both biosynthesis and degradation is appropriate.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":10},{"id":"GO:0009102","count":9},{"id":"GO:0042619","count":8},{"id":"GO:0009636","count":8},{"id":"GO:0019433","count":8}]},{"hash":"1925118962154731923","title":"Neural signaling and sensory perception","description":"The cluster shows strong representation of neuronal functions: synaptic regulation, receptor signaling, pain and temperature sensing, and cerebellar granule cell differentiation, along with SNARE-mediated neurotransmitter release. A few terms relate to adipose/macrophage differentiation, but the dominant theme is neural signaling and sensory processing.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":9},{"id":"GO:1900383","count":9},{"id":"GO:1901187","count":9},{"id":"GO:0007205","count":8},{"id":"GO:0010745","count":8}]},{"hash":"1777673865375191802","title":"NF-kappaB-driven Innate Immune Signaling","description":"The cluster is dominated by terms related to canonical NF-kappaB signaling, I-kappaB phosphorylation, and regulation of NF-kappaB activity, along with TLR4 signaling and type II interferon production, indicating coordinated innate inflammatory signaling primarily via NF-kappaB pathways.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0032609","count":3},{"id":"GO:0007252","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0006886","count":3}]},{"hash":"828898797429448695","title":"Golgi- and synaptic vesicle exocytosis","description":"This cluster centers on Golgi organization and vesicle trafficking with several exocytosis-related terms (presynaptic dense core vesicle exocytosis, acrosome reaction, vesicle maturation, Golgi to vacuole transport, and calcium-dependent exocytosis), suggesting a cohesive vesicle trafficking/exocytosis theme across Golgi- and neuron-like contexts. A couple of terms (thigmotaxis, glucose transport) are less connected but do not override the main pattern.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":4},{"id":"GO:0007340","count":3},{"id":"GO:0060050","count":3},{"id":"GO:0001966","count":3},{"id":"GO:0016188","count":2}]},{"hash":"1653862635778951715","title":"Developmental Cytoskeleton Remodeling and Migration","description":"The cluster is enriched for actin cytoskeleton reorganization, Rho signaling, microspike assembly, and regulation of cell migration, indicating proteins involved in cytoskeleton dynamics. Coupled with developmental terms like heart development, thymus development, and angiogenesis, the proteins likely participate in morphogenesis and organ development through cytoskeletal remodeling and signaling pathways (e.g., phosphatidylinositol-mediated signaling), with intracellular transport\u2019s role in delivering components for these processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0031532","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0048015","count":5},{"id":"GO:0007026","count":5}]},{"hash":"1042970135250058393","title":"Actin cytoskeleton remodeling and neurite protrusions","description":"Core theme is actin-driven membrane protrusions and cytoskeleton organization, including lamellipodium/filopodium assembly and Arp2/3 nucleation, with ties to neuron projection development and intracellular transport. The proteins likely regulate protrusive structures in migrating/neuronal cells and related signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0031175","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0030036","count":2}]},{"hash":"396198599159207822","title":"Inflammation and NF-kappaB signaling","description":"This cluster shows enrichment for immune and inflammatory functions (NF-kappaB transcription factor activity, IL-2 production, innate immune response) and related vascular remodeling terms (angiogenesis, smooth muscle cell proliferation). Protein quality control processes (chaperone-mediated assembly, proteasomal degradation) may accompany activation. Taken together, the terms point to an inflammation/immune signaling theme with some vascular remodeling context.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0050821","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0001525","count":3}]},{"hash":"5079572943162577","title":"Unknown","description":"The top GO terms cover a wide range of unrelated processes (morphine response, cell division and mitotic transitions, photosynthesis, retinal rod development, sex differentiation, and stress responses), with no clear common function tying the cluster together. This lack of a cohesive theme makes a precise, singular label inappropriate.","confidence":"","size":22,"edges":201,"triangles":1033,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043278","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0035955","count":5},{"id":"GO:0007091","count":5},{"id":"GO:1903646","count":5}]},{"hash":"636642204768516027","title":"Vertebrate organogenesis","description":"This cluster centers on developmental processes across multiple vertebrate organs (gonad, neural crest, forebrain, retina, inner ear, palate, kidney ureteric bud) and includes transcriptional regulation terms, suggesting involvement in embryonic development and regulation of gene expression during organogenesis. ","confidence":"Medium","size":22,"edges":12,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0008584","count":8},{"id":"GO:0090190","count":8},{"id":"GO:0001755","count":8},{"id":"GO:0006366","count":8}]},{"hash":"758297760072400958","title":"Cerebellar Purkinje cell development and transcriptional regulation","description":"This cluster centers on Purkinje cell\u2013related development in the cerebellum and transcriptional control processes. GO terms point to cerebellar Purkinje cell layer maturation and radial glia\u2013guided migration, alongside transcriptional regulation and chromatin modification (RNA polymerase II\u2013mediated transcription, histone deacetylation, chromatin silencing). The convergence on Purkinje cell development and gene expression suggests a cohesive cerebellar differentiation program.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0048755","count":2},{"id":"GO:1902499","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0070933","count":2}]},{"hash":"1616120350788308438","title":"Rho GTPase\u2013driven cytoskeleton and vesicle trafficking","description":"Top GO terms indicate regulation of GTPase activity and Rho signaling, pointing to cytoskeletal dynamics control. The inclusion of synaptic vesicle priming and short-term synaptic potentiation suggests vesicle trafficking and secretion, supported by membrane lipid-related processes. Despite a few obsolete terms, the core theme is cytoskeleton regulation coupled to vesicle movement and membrane trafficking.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0090286","count":3},{"id":"GO:0016082","count":2},{"id":"GO:0032024","count":2}]},{"hash":"1274932206772515233","title":"Cell-surface signaling and trafficking","description":"These proteins point to membrane-associated processes: GPI anchor biosynthesis for surface proteins, endosome-to-plasma-membrane transport, and synaptic/neuromuscular signaling. Additional terms cover metabolic signaling (glucose import in response to insulin) and immune/host-response signaling (interferon responses, biotic stimulus, and host-mediated defense). While diverse, the cluster centers on membrane-related signaling and trafficking that coordinate responses across tissues, including nervous, metabolic, and immune contexts.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":2},{"id":"GO:0050884","count":2},{"id":"GO:0044381","count":2},{"id":"GO:0035455","count":2},{"id":"GO:0009607","count":2}]},{"hash":"970825552806027615","title":"Integrin signaling and actin cytoskeleton remodeling","description":"This cluster is dominated by GO terms related to integrin activation and regulation, Rho signaling, stress fiber and filopodium assembly, and pathways impacting cell migration and sprouting angiogenesis, pointing to a cohesive role in integrin-mediated adhesion and cytoskeletal remodeling that drives cell movement. A few terms about glucose transport and DNA biosynthesis appear peripheral to this core theme, but the adhesive/cytoskeletal signal is strongest.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015758","count":3},{"id":"GO:0072659","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0033622","count":2},{"id":"GO:0046847","count":2}]},{"hash":"2056471721706553943","title":"Skin development and developmental signaling","description":"The cluster\u2019s top terms center on skin development and multicellular development, with supporting signals such as positive regulation of GTPase activity and protein kinase activity (serine/threonine) that modulate developmental signaling and cell proliferation. This suggests a cohesive theme of signaling-controlled development, particularly in skin or epithelial contexts, even though some terms (e.g., mRNA transport or cardiac-specific regulation) may reflect broader cellular processes or annotation noise. Overall, the shared motif appears to be developmental signaling pathways driving tissue formation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0043588","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0071456","count":6},{"id":"GO:0051028","count":5}]},{"hash":"546903378930778686","title":"Enteric nervous system and gut motility","description":"The cluster centers on neural control of the gut, with GO terms for enteric nervous system development, peristalsis, pain perception, and muscle relaxation, plus regulation of dopamine signaling and ERK cascade, indicating coordinated neural signaling and muscle activity governing gut motility. Additional terms like response to xenobiotic stimulus, diet-induced thermogenesis, and temperature response suggest concurrent metabolic and stress signaling in gut-associated tissues.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048484","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0030432","count":15},{"id":"GO:0070374","count":15},{"id":"GO:0002024","count":15}]},{"hash":"1573840826327350335","title":"Neural signaling and thermoregulation","description":"The top GO terms cluster around neural communication and temperature/pain regulation, including sensory perception of pain, cellular response to temperature, diet-induced thermogenesis, and neuropeptide signaling. Additional terms point to neuromodulation (dopamine receptor signaling, adenylate cyclase regulation) and related physiological processes like relaxed muscle tone, saliva secretion, and platelet activation, suggesting a neural/neuroendocrine influence with some peripheral effects. Together, these suggest a coherent theme of neural signaling intersecting with thermoregulation and sensory modulation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0002024","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0007218","count":12},{"id":"GO:0046541","count":12}]},{"hash":"396191690560480754","title":"Temperature-Responsive Signaling and Metabolic Regulation","description":"This cluster centers on signaling-related GO terms (positive regulation of Rho signaling, ERK cascade, GPCR signaling) and temperature/metabolism links (cellular response to temperature, diet-induced thermogenesis, signal-related blood pressure). Together they suggest proteins coordinating signaling networks that control metabolic and vascular responses to temperature, rather than a single, isolated function. Some terms like electron transport chain and cell wall catabolic processes appear as outliers or annotation noise, but the core theme is temperature-linked signal transduction and metabolism.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035025","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0070374","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7}]},{"hash":"283536267320554452","title":"Dopaminergic signaling with inflammatory and thermogenic responses","description":"This cluster is dominated by dopaminergic signaling terms (synaptic transmission and dopamine receptor signaling), indicating a core role in dopamine-mediated neurotransmission. The inflammatory and thermogenic GO terms (response to lipopolysaccharide, prostaglandin E stimulus, diet-induced thermogenesis, cellular response to temperature) suggest inflammation- and temperature-related modulation of dopamine signaling, with calcium release regulation supporting neuronal exocytosis. Overall, the proteins appear linked by dopamine signaling influenced by inflammatory and thermogenic cues.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":7},{"id":"GO:0071380","count":7},{"id":"GO:0051281","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0001963","count":7}]},{"hash":"339740291506989347","title":"Placental and embryonic development","description":"The top GO terms cluster around embryo and placental formation (placenta development, trophoblast differentiation, mesoderm development, left-right patterning, etc.), indicating a cohesive role in developmental processes rather than specific mature functions.  ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060806","count":16},{"id":"GO:0035270","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060707","count":16},{"id":"GO:0060972","count":16}]},{"hash":"1487485686160983890","title":"Unknown","description":"The GO terms span neuromuscular/posture control, immune/interferon responses, metabolism (steroid synthesis, insulin-responsive glucose import), biotic stimulus response, bone mineralization, and intracellular trafficking, with no clear single function tying them together; the absence of edges further suggests a lack of cohesive functional clustering. Therefore, the cluster is best labeled Unknown.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":3},{"id":"GO:0046597","count":3},{"id":"GO:0006694","count":2},{"id":"GO:0044381","count":2},{"id":"GO:0035455","count":2}]},{"hash":"50906273653790969","title":"Developmental transcription and morphogenesis","description":"The top GO terms cluster around embryonic and tissue development, including placenta, endocrine system development, cartilage morphogenesis, trophoblast differentiation, and left-right patterning, with supporting transcriptional regulation terms (DNA-templated transcription; negative regulation of transcription by RNA Pol II). This suggests a group of proteins involved in developmental differentiation programs and morphogenesis governed by transcriptional control.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060806","count":13},{"id":"GO:0035270","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0060972","count":13}]},{"hash":"1645711970839583789","title":"Vascular barrier regulation and coagulation with ECM remodeling","description":"This cluster centers on processes controlling endothelial barrier establishment/regulation, coagulation (Factor XII activation, plasminogen activation), and extracellular matrix remodeling (ECM disassembly, biomineral tissue development, amelogenesis). The presence of leukocyte migration and inflammatory response terms supports an inflammation-associated vascular remodeling theme, while transcription regulation terms may reflect shared regulatory proteins rather than a core function. Overall, the dominant theme ties endothelial barrier function to coagulation and matrix remodeling in inflammatory/tissue remodeling contexts.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:1903142","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0030194","count":5},{"id":"GO:0031214","count":4}]},{"hash":"442941636402779389","title":"Transmembrane solute transporters","description":"The GO terms are dominated by diverse transmembrane transport activities for ions and various substrates (nitrate, nitrite, sugars, xenobiotics, etc.), suggesting a cluster of membrane transporter proteins that move solutes across membranes rather than enzymes or structural components.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0035435","count":2}]},{"hash":"880148325538684610","title":"Transcriptional Regulation and Immune-Vascular Development","description":"The cluster is dominated by GO terms for both negative and positive regulation of RNA polymerase II transcription, suggesting a core transcriptional regulatory function. Additionally, multiple terms relate to endothelial barrier formation, leukocyte migration, complement activation, coagulation, and development, implying a link between transcriptional control and immune-vascular development. Some development-related terms (midbrain, biomineral tissue) may reflect broader developmental roles, but the shared theme appears to be transcriptional regulation intertwined with vascular and immune processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0045944","count":6},{"id":"GO:1903142","count":5},{"id":"GO:0002523","count":5},{"id":"GO:0030901","count":5}]},{"hash":"1312521408345294783","title":"Embryonic development and ECM\u2013integrin signaling","description":"Based on the top GO terms, this cluster centers on embryonic development (embryonic skeletal system development, Notch signaling, keratinocyte differentiation, single fertilization) and processes related to extracellular matrix organization and cell adhesion (collagen fibril organization, integrin-mediated signaling), with additional immune/tissue-remodeling context (leukocyte migration, negative regulation of platelet aggregation). This combination suggests a theme of developmental tissue formation coordinated by ECM signaling and cell-cell communication.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0030199","count":3},{"id":"GO:0031659","count":3},{"id":"GO:0007229","count":3}]},{"hash":"2251152605782811095","title":"Neural development and neuronal/glial apoptosis","description":"This cluster is dominated by neural development terms: neuron projection development, optic nerve development, neural plate morphogenesis, and neuron apoptotic processes, with glial cell apoptotic process also present. There are supportive terms about regulation of cell growth and TGF-beta signaling, consistent with developmental regulation. The overall theme is genes involved in neural development and programmed cell death within neural/glial contexts.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":3},{"id":"GO:0034349","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0051402","count":3}]},{"hash":"2156658119237716378","title":"Unknown","description":"The terms span a wide range of processes from DNA replication and repair to immune, muscle, neural development, and even organism-specific pathways like spore formation and lipid biosynthesis. There isn\u2019t a single cohesive function tying these proteins together, so this cluster is best labeled Unknown with no confidence.","confidence":"","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0043029","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0009749","count":4},{"id":"GO:0042542","count":4}]},{"hash":"1583425565775155616","title":"Neural Signaling and Sensory Perception","description":"This cluster centers on neural signaling and sensory processing, with multiple GO terms for sensory perception (pain, vision), visual learning, dopaminergic synaptic transmission, cocaine response, and regulation of ERK1/ERK2 signaling, all pointing to neural plasticity and behavioral regulation. Additional terms involve prostaglandin-related signaling and brain RAS, suggesting modulatory brain signaling, while heart development hints at broader developmental roles. Overall, it seems to group proteins involved in neural signaling, sensory perception, and related behavioral responses.","confidence":"High","size":21,"edges":158,"triangles":551,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0008542","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0070374","count":15},{"id":"GO:0048148","count":15}]},{"hash":"1953743775136139884","title":"DNA Damage Response and Apoptosis","description":"The top GO terms strongly point to DNA repair (base-excision repair, DNA recombination) and apoptotic processes, indicating a core role in the DNA damage response leading to cell fate decisions. Additional terms related to signaling and remodeling (phosphatidylinositol dephosphorylation, angiogenesis, neuron projection development) suggest these proteins also participate in broader stress signaling and tissue remodeling, reinforcing a theme around damage response and survival/death pathways.","confidence":"Medium","size":21,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046856","count":3},{"id":"GO:0006284","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0006310","count":3}]},{"hash":"1121561583321032679","title":"Neural Appetite Regulation and Brain Development","description":"The cluster is dominated by GO terms tied to neural signaling and development (neuropeptide signaling pathway, CNS and cerebral cortex development, neuron projection development) and behavioral regulation (eating behavior, positive regulation of appetite) as well as autonomic functions (regulation of blood pressure). While a term like cornified envelope assembly is less related to brain function and may reflect annotation noise, the prevailing themes point to neural control of feeding and brain maturation. Confidence: High","confidence":"","size":21,"edges":36,"triangles":16,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":3},{"id":"GO:1903575","count":2},{"id":"GO:0043488","count":2},{"id":"GO:0042755","count":2},{"id":"GO:0031175","count":2}]},{"hash":"832280492596270870","title":"Neuronal development and synaptic signaling","description":"Based on frequent terms including forebrain development, protein localization to synapse, Rho-mediated signaling, potassium ion transport, and cellular responses to glucose, the proteins appear enriched for neural development and synaptic function. Some outlier terms (defense response to Gram-positive bacterium, angiogenesis) may reflect broader annotations, but the dominant signal supports a neuronal growth and synaptic regulation theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046827","count":17},{"id":"GO:0050830","count":17},{"id":"GO:0030900","count":16},{"id":"GO:0035418","count":16},{"id":"GO:0071333","count":16}]},{"hash":"678219800447590428","title":"Broad signaling and transport functions","description":"The proteins are tied to a mix of signaling and regulatory processes\u2014phosphorylation events (carbohydrate and peptidyl-threonine), PI3K/AKT signaling, GPCR internalization, and transporter-related activity (glucose transmembrane transport), plus regulation of platelet activation and T cell survival. There are also muscle- and sensory-related terms (cardiac muscle contraction, sensory perception of sound). This suggests broad roles in signal transduction and cellular transport across membranes rather than a single cohesive pathway, so the label reflects the diversity of functions.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":3},{"id":"GO:0060048","count":2},{"id":"GO:0043491","count":2},{"id":"GO:0010763","count":2},{"id":"GO:0018107","count":2}]},{"hash":"967138015395244286","title":"Neuronal development and synaptic mitochondrial dynamics","description":"Top GO terms cluster around neuronal development and synaptic targeting, with accompanying mitochondrial distribution and microtubule dynamics, suggesting these proteins participate in shaping neuronal connectivity and synaptic machinery. There are a few outlier terms (e.g., B cell differentiation) likely due to annotation noise, but the core theme remains neuronal/synaptic function with mitochondrial and cytoskeletal regulation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901216","count":3},{"id":"GO:0045579","count":2},{"id":"GO:0031116","count":2},{"id":"GO:1900034","count":2},{"id":"GO:0090258","count":2}]},{"hash":"499029553592314065","title":"Spliceosome-Mediated mRNA Processing","description":"The top GO terms cluster around spliceosome-driven mRNA processing, including regulation and execution of alternative splicing, as well as cis-splicing and mRNA modification/stabilization, indicating a module focused on post-transcriptional regulation; the presence of eIF4F complex assembly suggests coordination with translation initiation.","confidence":"High","size":21,"edges":193,"triangles":1066,"max_degree":20,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":18},{"id":"GO:0031047","count":18},{"id":"GO:0000381","count":16},{"id":"GO:0000380","count":16},{"id":"GO:0045292","count":16}]},{"hash":"1417343453133273988","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":19},{"id":"GO:0000027","count":6},{"id":"GO:0071353","count":3},{"id":"GO:0006407","count":3},{"id":"GO:0000461","count":2}]},{"hash":"1955341425566397445","title":"Ribosome biogenesis and translation","description":"The top GO terms are strongly centered on protein synthesis: translation, cytoplasmic translation, ribosomal subunit biogenesis, and ribosomal export, with supporting signals from tRNA modification and RNA processing (spliceosome-mediated splicing). This suggests a cohesive cluster of ribosome assembly and translation machinery, with related regulatory processes like ubiquitination and cell cycle involvement. Despite no network edges, the GO signature points to a single functional module.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0002181","count":3},{"id":"GO:0042274","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0016567","count":3}]},{"hash":"58113255180464591","title":"Axon guidance and neural development signaling","description":"The top GO terms cluster around neural pathfinding and neuronal development (axon guidance, Roundabout/ROBO signaling, nervous system development) and cytoskeletal dynamics (filopodium assembly, small GTPase signaling) with ERK cascade involvement, suggesting a coherent theme of axon guidance and neural patterning, despite some broader developmental terms.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007411","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0002551","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007286","count":5}]},{"hash":"1354784878627514541","title":"Membrane remodeling and cell migration signaling","description":"This cluster\u2019s top GO terms cluster around membrane dynamics (positive regulation of membrane protein ectodomain proteolysis, plasma membrane tubulation), cytoskeletal remodeling (actin cortical patch assembly, extension of a leading process in radial glia), and signaling regulation (GTPase activity, CDK activity, tyrosine phosphorylation, IGF stimulus). Together these suggest coordinated membrane remodeling and signaling that drive cell movement and developmental processes like neuronal migration, with apoptosis and innate immunity appearing secondary. ","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051044","count":4},{"id":"GO:1990314","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0000147","count":3},{"id":"GO:0021816","count":3}]},{"hash":"930604471928350109","title":"ER stress response and apoptosis regulation","description":"This cluster is dominated by GO terms related to the unfolded protein response and ER stress, including response to unfolded protein, translation initiation regulation under ER stress, and negative regulation of ER stress\u2013related apoptosis. While cell division terms are present, the strongest signal ties to ER stress management, protein folding, and apoptosis control, suggesting a cohesive functional theme around ER stress response and its impact on cell fate.","confidence":"Medium","size":21,"edges":19,"triangles":3,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902042","count":4},{"id":"GO:0046661","count":3},{"id":"GO:0036494","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006986","count":3}]},{"hash":"593331142141790300","title":"Cell cycle and transcription regulation","description":"Top terms show a strong enrichment for DNA-templated transcription and RNAP II regulation, alongside key cell-cycle transitions (G1/S, G2/M, mitotic re-entry) and mitosis-related chromatin changes. This points to a cohesive module where transcriptional control is tightly coordinated with cell-cycle progression. The presence of mammary alveolus development and insulin signaling terms suggests tissue-specific context, but the core theme remains cell cycle regulation coupled with transcriptional control.","confidence":"High","size":21,"edges":12,"triangles":2,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0000082","count":6},{"id":"GO:0030857","count":5},{"id":"GO:0046626","count":5},{"id":"GO:0060749","count":5}]},{"hash":"501278291898809037","title":"DNA repair and developmental signaling","description":"The top GO terms show DNA repair prominently, along with several developmental processes (heart and nervous system/forebrain development) and signaling-related responses (apoptosis, phosphorylation, and responses to prostaglandin and GM-CSF). This suggests a cluster of proteins that link genome maintenance with developmental signaling and cellular stress responses, rather than a single, narrow function. The lack of edges indicates grouping by shared GO annotations rather than direct interactions, so the label emphasizes a broad theme of DNA damage response intertwined with development.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":5},{"id":"GO:0097194","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0030900","count":3},{"id":"GO:0010763","count":3}]},{"hash":"1898191256807354783","title":"Neurodevelopmental gene regulation and cell cycle","description":"This cluster is enriched for neural development terms (forebrain development, neural tube closure, multicellular organism development) and transcriptional regulation (DNA-templated transcription), with mitotic cell cycle indicating proliferative processes during development. While there are some stress/immune-related terms present, the dominant pattern points to neurodevelopmental gene regulation and proliferation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":14},{"id":"GO:0006351","count":13},{"id":"GO:0030900","count":12},{"id":"GO:0006349","count":12},{"id":"GO:0071276","count":12}]},{"hash":"1941143725543345044","title":"Vertebrate embryonic development and organogenesis","description":"The top GO terms cluster around broad embryonic development across multiple tissues and organs\u2014primitive streak formation, heart and forebrain development, cranial skeleton morphogenesis, odontogenesis, PNS neuron development, and gonad formation\u2014indicating a group of proteins involved in vertebrate embryogenesis and organogenesis. The negative regulation of transcription by RNA polymerase II likely reflects developmental gene-expression control within this process.","confidence":"High","size":21,"edges":5,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0090009","count":8},{"id":"GO:0048701","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0008584","count":8}]},{"hash":"803646175596703158","title":"Flavonoid Biosynthesis and Glucoside Formation","description":"This cluster is dominated by GO terms for biosynthesis and modification of flavonoids and their glycosides, including anthocyanin biosynthesis, kaempferol O-glucoside biosynthesis, and flavonoid glucuronidation, suggesting a shared role in plant secondary metabolite production. Some terms (glycolipid and lipoteichoic acid biosynthesis) are broader or less directly related, and a cell cycle term appears as an outlier, indicating possible annotation noise. Overall, the core theme is flavonoid biosynthesis and glycoside formation.","confidence":"Medium","size":21,"edges":75,"triangles":117,"max_degree":18,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":14},{"id":"GO:0070980","count":12},{"id":"GO:0008360","count":12},{"id":"GO:0071412","count":12},{"id":"GO:0070395","count":12}]},{"hash":"267382322152754978","title":"Neural development and DNA damage response","description":"The top terms include forebrain development and central nervous system neuron development, indicating a neural-development theme. Supporting terms such as DNA repair and mitotic G2 DNA damage checkpoint signaling suggest genome maintenance during proliferation, which can co-occur in developing neural cells. Other terms (mRNA processing, transcription, insulin signaling, wound response) are broader but do not override the core neural-development/damage-response pattern. ","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0021954","count":3},{"id":"GO:0007095","count":3}]},{"hash":"955425915908311349","title":"Endosomal Transport and GTPase Regulation","description":"Dominant GO terms point to membrane trafficking involving endosomes and Golgi (late endosome to Golgi transport; plasma membrane to endosome transport) and regulation/activation of GTPase activity, indicating a coherent cluster of endosomal sorting and GTPase-driven trafficking. Some development-related terms are present but appear less central to the core function, so confidence is moderate.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034499","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0048227","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0019933","count":3}]},{"hash":"1630549240320314175","title":"Mammary gland development and lactation","description":"The cluster is most strongly associated with mammary gland biology, including mammary gland development, lactose biosynthetic process, and signals related to lactation and mammary involution. Other terms in the set point to tissue remodeling and epithelial dynamics that can accompany gland development, though a few (e.g., zona pellucida penetration, tracheal system migration) are less directly related to mammary function. Overall, the dominant themes support a mammary gland\u2013related functional cluster, with some contextually broader processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0075015","count":3},{"id":"GO:2000274","count":3},{"id":"GO:0045600","count":3},{"id":"GO:0048147","count":2}]},{"hash":"1731022501241804116","title":"Actin dynamics and endocytosis regulation","description":"GO terms point to actin cytoskeleton remodeling (GTPase activity, Arp2/3 regulation, actin patch assembly, barbed-end capping) and clathrin-dependent endocytosis, with some signaling/apoptotic terms as ancillary context. This suggests a cohesive theme of actin remodeling linked to endocytic pathways.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":12},{"id":"GO:0034316","count":11},{"id":"GO:0000147","count":9},{"id":"GO:0050731","count":8},{"id":"GO:0006915","count":8}]},{"hash":"866142550707738236","title":"Neuronal mitochondrial stress and apoptosis","description":"This cluster centers on mitochondrial functions in neurons: mitochondrial translation/translation-related processes, ubiquinone biosynthesis, and tRNA aminoacylation all point to mitochondrial protein synthesis; the cytochrome c release and hypoxia response terms indicate mitochondrial-mediated apoptotic pathways and cellular stress. The neuron-specific term for Purkinje cell layer morphogenesis suggests a neuronal developmental context. Taken together, the terms imply a coherent theme of mitochondrial regulation of neuronal survival and development.","confidence":"High","size":21,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0051402","count":2},{"id":"GO:0090200","count":2},{"id":"GO:0006919","count":2},{"id":"GO:0071456","count":2}]},{"hash":"2276049231034321077","title":"Neural and cardiac development via GTPase signaling","description":"The top GO terms link neural development (spinal cord development, myelination, sensory perception of sound) and heart development/contraction with positive regulation of GTPase activity and cytoskeleton dynamics (microtubule-based movement, cell migration), suggesting a cohesive role in signaling and cytoskeletal remodeling that shapes both nervous and cardiovascular tissues.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0021510","count":3},{"id":"GO:0035264","count":3}]},{"hash":"1191061863938509689","title":"Vesicle trafficking and organ morphogenesis","description":"The cluster is enriched for membrane transport terms, including plasma membrane to endosome transport, ER-to-Golgi vesicle transport, and recycling endosome to Golgi transport, pointing to a core role in intracellular vesicle trafficking. Additional terms related to tissue morphogenesis (bone development, metanephric tubule development, lymph vessel morphogenesis) suggest these trafficking components also participate in developmental processes that rely on targeted vesicle transport. Together, these signals support a cohesive theme centered on vesicle trafficking with a developmental context.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048227","count":3},{"id":"GO:1902953","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0051901","count":3},{"id":"GO:0060348","count":3}]},{"hash":"229330424650244293","title":"Actin Cytoskeleton Remodeling and Migration Regulation","description":"This cluster centers on actin cytoskeleton organization and Rho signaling, with multiple terms tied to cell migration, including regulation of sprouting angiogenesis and vascular remodeling. While a Golgi localization term appears, the dominant theme links cytoskeleton dynamics to cell movement and morphogenesis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":4},{"id":"GO:0051683","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0002692","count":4}]},{"hash":"46268795707688754","title":"Endocytosis and Cytoskeletal Regulation","description":"This cluster is enriched for terms related to membrane trafficking and cytoskeletal dynamics, including endocytosis, pinocytosis, plasma membrane to endosome transport, and regulation of Rho/GTPase signaling as well as actin cytoskeleton remodeling. While some terms touch broader signaling pathways (Wnt, thrombin receptor), they appear in the same functional context of coordinating endocytic processes with cytoskeletal remodeling and cell shape/polarity. The lack of observed edges in the current network does not undermine the functional cohesion suggested by the GO terms.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0031532","count":2}]},{"hash":"1045173937936801083","title":"Ubiquitin-Proteasome Mediated Proteolysis","description":"This cluster is dominated by GO terms related to ubiquitin-dependent protein catabolic processes, including K48- and K63-linked ubiquitination and SCF-dependent proteasomal degradation. The prevalence of polyubiquitination and proteasome-associated catabolism strongly indicates a cohesive proteostasis theme via the ubiquitin-proteasome system. Some entries reference stress responses and cell-cycle checkpoints, which may reflect regulation of proteolysis under stress, while unrelated terms like synapse assembly appear peripheral. Overall, the data point to a proteolysis-focused ubiquitin-proteasome cluster.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:1903378","count":10},{"id":"GO:0070936","count":9},{"id":"GO:0000209","count":9},{"id":"GO:0031146","count":9}]},{"hash":"977052383014650869","title":"Glycinergic neurotransmission and glycine transport","description":"The top GO terms cluster tightly around glycine handling at synapses\u2014glycine import, glycinergic synaptic transmission, glycine secretion, and regulation of glycinergic signaling\u2014with supportive entries for taurine and monoamine (dopamine/serotonin) uptake. This points to a cohesive theme of glycine-centered neuronal signaling and amino acid transport, despite a couple peripheral terms. Confidence in this label is High.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036233","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0021984","count":2},{"id":"GO:0060012","count":2},{"id":"GO:1905847","count":2}]},{"hash":"1222966837186909050","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071036","count":3},{"id":"GO:1990603","count":3},{"id":"GO:0071031","count":3},{"id":"GO:0006808","count":3},{"id":"GO:0071044","count":3}]},{"hash":"1635636459868462384","title":"Mitochondrial respiration and ribosome assembly","description":"The top GO terms are dominated by mitochondrial processes: NADH to ubiquinone electron transport and complex II assembly, along with mitochondrial ribosome assembly. This points to a cohesive theme around mitochondrial energy production and mitochondrial protein synthesis, with other terms likely reflecting peripheral or overlapping cellular processes. Confidence in the label is Moderate due to some non-mitochondrial terms present.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034553","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0061668","count":2},{"id":"GO:0006067","count":2},{"id":"GO:1904743","count":2}]},{"hash":"433818924576691700","title":"Chromatin remodeling and transcription regulation","description":"The terms point to a common theme of controlling gene expression via chromatin state (chromatin remodeling, nucleosome assembly) and transcriptional regulation by RNA polymerase II (both negative and positive regulation). The developmental and differentiation terms (midbrain development, erythrocyte/megakaryocyte differentiation) and even the LPS response can reflect transcription programs governed by chromatin dynamics, supporting a cohesive theme around chromatin-mediated transcription control.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0043044","count":6},{"id":"GO:0007338","count":5},{"id":"GO:0032496","count":5},{"id":"GO:0030901","count":5}]},{"hash":"998719623978108440","title":"Inflammation- and metabolism-related signaling","description":"The GO terms cluster around immune cell chemotaxis (neutrophil and eosinophil), regulation of inflammatory mediators (TNF), pain perception, and GPCR signaling, with additional links to thermogenesis, blood pressure, and energy metabolism (electron transport). This suggests a broad theme of inflammatory signaling intertwined with metabolic processes, rather than a single cohesive pathway. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090023","count":10},{"id":"GO:0032720","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0008284","count":10},{"id":"GO:0048245","count":10}]},{"hash":"2036339561332961706","title":"Mechanotransduction-driven cytoskeletal remodeling and innate immunity","description":"Based on the prominent terms for cellular response to mechanical stimulus, actin filament bundle assembly, cell migration, and innate immune signaling (including the NOD2 pathway and innate immune response), the cluster likely comprises proteins coordinating mechanosensing with cytoskeletal dynamics and inflammatory signaling. The presence of protein homooligomerization supports multi-protein complexes in these processes, while bone development appears less central. Confidence reflects a coherent mechanotransduction/cytoskeleton-immunity theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071260","count":7},{"id":"GO:0032088","count":7},{"id":"GO:0051017","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0016477","count":6}]},{"hash":"555709995320070247","title":"Vertebrate Developmental Morphogenesis","description":"The top GO terms concentrate on vertebrate development and morphogenesis (forelimb morphogenesis, brain ventricle development, kidney collecting duct development) with a notable retinoic acid response, suggesting a developmental/organogenesis theme. An outlier term related to ascospore formation may be noise rather than representative of the cluster\u2019s core function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":4},{"id":"GO:0032526","count":3},{"id":"GO:0030437","count":3},{"id":"GO:0072205","count":3},{"id":"GO:0021670","count":3}]},{"hash":"722021863577465577","title":"Inflammatory signaling and tissue development","description":"The cluster centers on immune/inflammatory processes (defense against bacteria, immune response, prostaglandin signaling) and key signaling cascades (ERK/MAPK) that regulate cell proliferation and development, including heart development. While there are also metabolism-related terms (diet-induced thermogenesis), the dominant themes are inflammatory signaling and growth/development pathways, suggesting a cohesive group around inflammation-linked signaling and tissue development.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042742","count":10},{"id":"GO:0071380","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0008284","count":8}]},{"hash":"2124627093799774808","title":"Dopamine GPCR signaling and regulation","description":"The top GO terms cluster around dopaminergic signaling and GPCR-coupled regulation of cAMP (negative regulation of adenylate cyclase, GPCR acetylcholine signaling) and related dopamine transport, suggesting a core theme of dopamine signaling and GPCR-mediated regulation. Some terms about development and immune cells are present but secondary to the dominant dopaminergic signaling pattern.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":20},{"id":"GO:0090075","count":20},{"id":"GO:0007194","count":20},{"id":"GO:0016998","count":20},{"id":"GO:0040015","count":20}]},{"hash":"1833271625339668674","title":"Developmental vascular and germ cell signaling","description":"This cluster\u2019s terms span spermatogenesis, vascular development (blood vessel, endothelial barrier, lung development), and hematopoietic differentiation, all pointing to developmental programs. Also present are general signaling and regulatory processes (Rho signaling, NF-kappaB regulation, receptor clustering) and apoptosis, suggesting coordinated development through signaling rather than a single tissue-specific function. The label emphasizes a broad developmental signaling theme rather than a narrow path.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007283","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0010800","count":2},{"id":"GO:0001568","count":2},{"id":"GO:0090557","count":2}]},{"hash":"241048462970161959","title":"Adaptive and Innate Immune Signaling","description":"This cluster centers on immune system activation across both innate and adaptive arms. High representation of phagocytosis recognition, innate defense, Fc receptor signaling, B cell receptor signaling, adaptive immune response, and cytokine-related pathways (e.g., IL-2 production, type I interferon signaling) suggests a coordinated immune signaling module spanning antigen recognition, phagocytic activity, and cytokine responses.","confidence":"High","size":20,"edges":26,"triangles":3,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":12},{"id":"GO:0050853","count":11},{"id":"GO:0071226","count":11},{"id":"GO:0002250","count":9},{"id":"GO:1900042","count":9}]},{"hash":"2147806246739314245","title":"Multilineage cell fate specification","description":"This cluster centers on developmental differentiation across diverse tissues\u2014spinal cord neurons/oligodendrocytes, cortical interneurons, subpallium, pancreas, bronchioles, skeletal muscle, and heart\u2014driven by transcriptional regulation (RNA polymerase II). The shared theme is embryonic cell fate specification across multiple lineages.","confidence":"High","size":20,"edges":139,"triangles":681,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":17},{"id":"GO:0021530","count":16},{"id":"GO:0021520","count":16},{"id":"GO:0021892","count":16},{"id":"GO:0060163","count":16}]},{"hash":"365976389013856179","title":"Neuronal synaptic signaling and plasticity","description":"The top GO terms emphasize synaptic regulation and signaling (including ephrin receptor signaling and GPCR pathways), and processes that modulate synapse structure and plasticity, which are central to neuronal communication. Additional terms about ubiquitination, integrin-mediated adhesion, cell migration, and sensory modalities (sound/balance) suggest related cellular adhesion and trafficking roles that maintain and adapt synapses, as well as sensory neurons. Overall, these functions point to a cohesive theme of synaptic signaling and plasticity with supporting adhesion and trafficking mechanisms.","confidence":"Medium","size":20,"edges":71,"triangles":32,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0007605","count":5},{"id":"GO:0051835","count":5},{"id":"GO:0016567","count":5},{"id":"GO:1900383","count":5}]},{"hash":"1521028455369816494","title":"Neural Development and Synaptic Signaling","description":"This cluster centers on neuronal development processes (planar cell polarity in neural tube closure; convergent extension in neural plate elongation) together with synaptic function (chemical synaptic transmission, receptor clustering, excitatory postsynaptic potential regulation) and Rho/GTPase signaling that shapes neuronal structure and connectivity. Behavioral terms like social and exploration behavior likely reflect neural circuit outcomes. The common theme is neurite development and synaptic activity shaping neural function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090179","count":6},{"id":"GO:0035176","count":6},{"id":"GO:0035640","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0007268","count":5}]},{"hash":"1494439609764828133","title":"Epithelial Differentiation and Actin Cytoskeleton Remodeling","description":"The top GO terms strongly indicate epithelial lineage commitment (keratinocyte and lung epithelial differentiation) and extensive actin cytoskeleton dynamics (polymerization, nucleation, and filament network formation). The presence of mitochondrial fission regulation and glucocorticoid signaling suggests accompanying signaling and organelle remodeling associated with differentiation and epithelial function. Altogether, the cluster appears to represent epithelial differentiation coupled with cytoskeletal remodeling and related signaling processes.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0030216","count":4},{"id":"GO:0090140","count":4},{"id":"GO:0030041","count":4},{"id":"GO:0045010","count":4},{"id":"GO:0051639","count":4}]},{"hash":"1235902220463693813","title":"Hormone Biosynthesis and Xenobiotic Metabolism","description":"The cluster shows enrichment in hormone-related biosynthetic processes (prostaglandin, bile acid, testosterone; brassinosteroid homeostasis; vitamin D response), alongside catabolic processes for diverse compounds (carbazole, alkaloids, camphor). These collectively point to a shared theme of biosynthesis and detoxification/metabolism of signaling molecules and xenobiotics.","confidence":"Medium","size":20,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":12},{"id":"GO:0001516","count":11},{"id":"GO:0033280","count":11},{"id":"GO:1900087","count":11},{"id":"GO:0010268","count":11}]},{"hash":"540287075451846966","title":"Amino acid catabolism and energy metabolism","description":"The top terms are dominated by amino acid catabolic processes (alanine, leucine, kynurenine, lysine) and core energy pathways (pyruvate metabolism, gluconeogenesis) plus a starvation-response signal, suggesting a metabolic cluster focused on amino-acid\u2013driven energy production. However, concepts like Notch signaling, liver development, and sodium transport add heterogeneity, so the label reflects the main metabolic theme with moderate confidence.","confidence":"Medium","size":20,"edges":189,"triangles":1122,"max_degree":19,"top_function":"mitochondrion organization","top_go_terms":[{"id":"GO:0019878","count":8},{"id":"GO:0042853","count":8},{"id":"GO:0097053","count":8},{"id":"GO:0007219","count":8},{"id":"GO:0006094","count":6}]},{"hash":"1971414618398469466","title":"Unknown","description":"The top GO terms span immune processes (B cell affinity maturation, T cell activation-induced cell death) and broad developmental and vascular functions (heart development, midbrain morphogenesis, vasoconstriction), along with cytoskeletal remodeling and migration. The lack of a single cohesive theme and the absence of edges suggest these proteins do not form a clearly unified functional cluster, so a definitive, specific label isn\u2019t supported.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002344","count":11},{"id":"GO:0007507","count":10},{"id":"GO:0010765","count":9},{"id":"GO:0045907","count":9},{"id":"GO:0016477","count":9}]},{"hash":"1380510093611469173","title":"Regulatory T cell differentiation and mucosal immunity","description":"This cluster centers on regulatory T cell differentiation and suppression of T cell proliferation, paired with signals of mucosal innate immunity, macrophage activation, and inflammatory lipid signaling (phospholipase activity, arachidonic acid, phosphatidic acid). The GO terms collectively point to immune regulation in mucosal contexts with lipid-mediated signaling and macrophage involvement.","confidence":"High","size":20,"edges":75,"triangles":135,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0002361","count":7},{"id":"GO:0042130","count":7},{"id":"GO:0006654","count":6},{"id":"GO:0050482","count":6},{"id":"GO:0010744","count":6}]},{"hash":"358310609630305519","title":"Endothelial angiogenesis and vesicle trafficking","description":"The cluster shows strong signals for endothelial-related angiogenesis (negative regulation of endothelial cell migration in sprouting angiogenesis; endothelial tube lumen extension) together with intracellular trafficking processes (Golgi localization; endosome-to-membrane transport) and small GTPase\u2013mediated signaling that governs vesicle trafficking and cytoskeletal dynamics. This suggests a cohesive theme of proteins coordinating angiogenic endothelial behavior with vesicle trafficking and Golgi function.","confidence":"Medium","size":20,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090051","count":3},{"id":"GO:0051683","count":3},{"id":"GO:0090334","count":3},{"id":"GO:0097498","count":3},{"id":"GO:0007264","count":3}]},{"hash":"2241474304614789490","title":"Transmembrane Ion and Metabolite Transporters","description":"The GO terms show a cohesive theme of transporting substances across membranes, including multiple ion transports (sodium, potassium, phosphate, nitrite, nitrate) and various metabolite transports, as well as neurotransmitter loading into synaptic vesicles. This pattern strongly indicates a cluster of membrane transport proteins with diverse substrates.","confidence":"High","size":20,"edges":41,"triangles":35,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":6},{"id":"GO:0042128","count":6},{"id":"GO:0015757","count":6},{"id":"GO:0035435","count":6},{"id":"GO:0035725","count":6}]},{"hash":"1788992723728781353","title":"Developmental signaling and cell-cycle regulation","description":"Most prominent terms describe development across tissues (root, superior colliculus) and pathways governing cell behavior, including Wnt signaling linked to EMT and regulation of apoptosis, along with cell-cycle control (positive/negative regulation) and GTPase activity. The presence of NLS-mediated nuclear import and proton transport hints at accompanying nuclear signaling and membrane transport roles. Together, these GO terms point to proteins involved in coordinating developmental signaling with cell-cycle progression.","confidence":"Medium","size":20,"edges":179,"triangles":968,"max_degree":19,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0048364","count":15},{"id":"GO:0006607","count":13},{"id":"GO:0043547","count":13},{"id":"GO:0007050","count":13},{"id":"GO:0086091","count":12}]},{"hash":"2301129735584463269","title":"RNA processing and mRNA stability regulation","description":"Most of the top GO terms converge on RNA maturation and turnover: nuclear mRNA polyadenylation, spliceosome-mediated splicing, mRNA modification, and regulation of mRNA stability/stability in response to stress, including poly(A) tail shortening. While a couple of terms touch on translation initiation and development (IRES-dependent translation and blastocyst formation), the dominant signal is RNA processing and stability control, suggesting proteins in this cluster function in mRNA maturation and post-transcriptional regulation.","confidence":"High","size":20,"edges":30,"triangles":11,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":15},{"id":"GO:0045292","count":14},{"id":"GO:0016556","count":13},{"id":"GO:0010610","count":13},{"id":"GO:0060211","count":13}]},{"hash":"1338719926220931793","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":18,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":3},{"id":"GO:0098789","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0060348","count":3}]},{"hash":"1387589757567062457","title":"Hippo-Wnt Growth Control","description":"The cluster\u2019s top GO terms center on Hippo signaling, Wnt signaling, and negative regulation of proliferation, plus apoptosis, transcription, DNA repair, and keratinocyte differentiation. This suggests a network coordinating cell growth, survival, and fate decisions (including differentiation), with potential skin-related or cancer-relevant contexts. Thus, labeling it as Hippo-Wnt Growth Control captures the core theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060044","count":14},{"id":"GO:0035329","count":14},{"id":"GO:0090263","count":14},{"id":"GO:0006915","count":14},{"id":"GO:0030216","count":14}]},{"hash":"2292155394222333097","title":"Cardiac Muscle Contraction and Sarcomere Organization","description":"The cluster is dominated by GO terms related to heart muscle function and structure, including cardiac muscle contraction, sarcomere organization, and ventricular cardiac muscle tissue morphogenesis, with an associated fiber-type transition. While there are a few terms linked to nervous system development and axon guidance, these appear peripheral to the core cardiac-focused functions, making a heart muscle development/contraction theme the best overall label.","confidence":"High","size":20,"edges":10,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060048","count":9},{"id":"GO:0045214","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0007411","count":7},{"id":"GO:2001200","count":6}]},{"hash":"1231968642320214871","title":"Mitochondrial import and Complex III assembly","description":"This cluster is dominated by GO terms related to mitochondrial inner membrane protein insertion, assembly of the respiratory chain Complex III, and cellular responses to oxidative stress, which together point to mitochondrial biogenesis and maintenance. Additional terms on ubiquitin-like protease regulation and ER-Golgi vesicle transport suggest broader protein quality control and trafficking roles that can accompany mitochondrial function. The DNA replication term and transformation competence are less directly tied but may reflect shared cellular maintenance processes. Overall, the theme centers on mitochondrial protein handling and energy metabolism with linked stress responses.","confidence":"Medium","size":20,"edges":18,"triangles":3,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0032979","count":3},{"id":"GO:0030420","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0034551","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1481090458594599657","title":"Mitochondrial protein import and calcium homeostasis","description":"This cluster is enriched for mitochondrial-related GO terms, notably protein import into the mitochondrial matrix and calcium handling within mitochondria, suggesting a core theme of mitochondrial protein maturation and Ca2+ regulation. Additional terms cover protein folding and various catabolic processes, plus some RNA decay/transcription terms that may reflect broader cellular housekeeping or annotation overlap. Overall, the dominant signal points to mitochondrial function, particularly import and calcium management.","confidence":"Medium","size":20,"edges":92,"triangles":177,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0010124","count":2},{"id":"GO:0051560","count":1},{"id":"GO:0036444","count":1}]},{"hash":"1905148980829971405","title":"Metabolic Biosynthesis and Signaling","description":"The top GO terms cover a wide range of biosynthetic and catabolic processes (lysine, tryptophan, alanine; biotin; heme; sphinganine) along with lipid transport, plus broad signaling and transcription activities (insulin stimulus response, salicylic acid\u2013mediated signaling, DNA-templated transcription). This pattern suggests a cluster of proteins involved in general metabolic biosynthesis and regulatory signaling rather than a single, cohesive pathway. Confidence: Medium","confidence":"","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033362","count":9},{"id":"GO:0019441","count":9},{"id":"GO:0015908","count":9},{"id":"GO:0009102","count":9},{"id":"GO:0032869","count":9}]},{"hash":"2235130579685909117","title":"Diverse Metabolite Biosynthesis","description":"The set of top GO terms centers on biosynthetic processes for a wide range of metabolites, including plant-derived compounds (anthocyanin, phenylpropanoid, tropane alkaloid) and microbial polymers (lipopolysaccharide, colanic acid) as well as biopolyesters (poly-hydroxybutyrate). This suggests a generic annotation of biosynthetic capability rather than a single defined pathway, so a label that captures diverse biosynthesis is most representative.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0009718","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0042619","count":8},{"id":"GO:0055114","count":8},{"id":"GO:0009242","count":6}]},{"hash":"641011235866850677","title":"Autonomic GPCR signaling and energy metabolism","description":"The dominant GO terms point to GPCR-mediated signaling that regulates autonomic physiological processes (blood pressure, saliva secretion, muscle relaxation, dopamine signaling, pain perception) and energetics (thermogenesis, temperature response, electron transport chain). This suggests a cohesive theme of neural control of physiology coupled with metabolic energy regulation.","confidence":"Medium","size":20,"edges":13,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0007190","count":11},{"id":"GO:0019233","count":10}]},{"hash":"1777479669530364987","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006281","count":3}]},{"hash":"1213108275529988724","title":"Developmental signaling and cytoskeletal remodeling","description":"The top GO terms point to forebrain and heart/vascular development, tissue morphogenesis, and cytoskeletal organization, alongside signaling pathways such as VEGF, HGF, and collagen-activated RTK, plus actin remodeling and cell migration. This suggests a cluster of proteins involved in developmental signaling coupled with cytoskeletal dynamics across multiple tissues (neural, vascular, cardiac, fibroblast contexts).","confidence":"Medium","size":20,"edges":152,"triangles":645,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":20},{"id":"GO:0035729","count":20},{"id":"GO:0002333","count":20},{"id":"GO:0006939","count":20},{"id":"GO:0030866","count":20}]},{"hash":"899943020371314979","title":"Cell signaling and protein regulation","description":"The top GO terms center on regulation of signaling pathways (GTPase activity, tyrosine phosphorylation, TGF-beta, Wnt, B cell receptor) and protein handling processes (ubiquitination, ERAD), with related cytoskeletal and splicing activities. This suggests a coherent theme of signaling control coupled with post-translational modification and protein quality control, rather than a single obvious function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":10},{"id":"GO:0050731","count":9},{"id":"GO:0071560","count":9},{"id":"GO:0000209","count":8},{"id":"GO:0000398","count":7}]},{"hash":"1376083354913229074","title":"Angiogenesis and vascular development signaling","description":"This cluster is dominated by GO terms for blood vessel formation and angiogenesis (labyrinthine layer blood vessel development; positive regulation of angiogenesis) and vascular development, with supporting signaling pathways (Wnt, ephrin receptor signaling, Hippo) and related processes such as apoptosis and differentiation, suggesting a cohesive network governing vascular and epithelial cell growth and fate.","confidence":"Medium","size":20,"edges":20,"triangles":11,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060716","count":11},{"id":"GO:0090263","count":10},{"id":"GO:0048013","count":10},{"id":"GO:0043552","count":10},{"id":"GO:0050852","count":10}]},{"hash":"2162850784883980445","title":"Mitochondrial assembly and calcium signaling","description":"The cluster summaries include mitochondrial respiratory chain complex IV assembly, calcium release regulation, and metabolic signaling (insulin response, phosphorylation), pointing to a mitochondria-centered signaling and metabolism theme. While some terms (e.g., synaptic vesicle exocytosis, focal adhesions) are broader, they can be linked to energy/calcium dynamics driven by mitochondria, supporting a cohesive, mitochondria-associated function. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":3},{"id":"GO:0016079","count":2},{"id":"GO:0018107","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0007507","count":2}]},{"hash":"444844074973752694","title":"MAPK Regulation and Mitotic Control","description":"These proteins appear to cluster around regulation of MAPK signaling (ERK/JNK), including negative regulation and tyrosine dephosphorylation, and are also tied to mitotic processes (cell cycle, spindle-kinetochore attachments). The combination of MAPK activity regulation and mitosis-related terms suggests a module that coordinates signaling with cell division, with some links to T cell signaling and vascular permeability via MAPK pathways.","confidence":"High","size":20,"edges":186,"triangles":1071,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":18},{"id":"GO:0000200","count":18},{"id":"GO:0050860","count":18},{"id":"GO:0035335","count":15},{"id":"GO:0007049","count":15}]},{"hash":"677278678237614813","title":"Ribosome Biogenesis and rRNA Maturation","description":"Dominant GO terms are maturation of SSU/5.8S/LSU rRNA, rRNA methylation, and ribosome biogenesis, suggesting this cluster groups proteins involved in ribosome assembly and rRNA processing. While some developmental terms appear, the core theme is RNA maturation tied to ribosome production.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":6},{"id":"GO:0000466","count":5},{"id":"GO:0036265","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0000398","count":4}]},{"hash":"125271141688820807","title":"Embryonic neural and eye development with transcription regulation","description":"The leading GO terms point to transcription by RNA polymerase II and its negative regulation, paired with embryonic development and neural/eye-specific processes (in utero development, retina/eye morphogenesis, cerebral cortex development). Additional terms like pituitary and gonad development fit into a broader embryonic organogenesis program, while neuron maturation aligns with neural development. A lipopolysaccharide response term is a minor outlier. This supports a cohesive theme of transcription-regulated embryonic neural/eye development.","confidence":"High","size":20,"edges":10,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0001701","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0048048","count":7},{"id":"GO:0021983","count":6}]},{"hash":"632915479144288764","title":"Lipid Metabolism and Vitamin Biosynthesis","description":"The top GO terms center on lipid-related processes (triglyceride catabolic, phosphatidylserine catabolic, phospholipid dephosphorylation) and vitamin biosynthesis (biotin, menaquinone), suggesting the proteins collectively participate in lipid metabolism and vitamin biosynthesis pathways. While a heart development term appears, it is not as representative as the lipid/vitamin signals, so the label emphasizes the core metabolic theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0007507","count":4},{"id":"GO:0042619","count":3},{"id":"GO:0009636","count":3},{"id":"GO:0009102","count":3}]},{"hash":"1630652429607578961","title":"Synaptic Signaling and Sensory Perception Regulation","description":"The top terms cluster around neuronal communication, synaptic vesicle control (SNARE regulation), and sensory detection (pain, thermoception), with related GPCR and ephrin signaling, indicating a cohesive theme of synaptic signaling and sensory processing regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1900383","count":7},{"id":"GO:0007205","count":7},{"id":"GO:0098907","count":7},{"id":"GO:1901187","count":7},{"id":"GO:0050966","count":6}]},{"hash":"1314877259133003534","title":"Growth factor signaling and morphogenesis","description":"This cluster centers on cellular responses to growth factor cues (retinoic acid, PDGF, TGF-beta) and processes that sculpt tissue architecture, such as myoblast fusion, smooth muscle migration, and branching morphogenesis in mammary glands. While a couple of terms (e.g., adult locomotory behavior, meiosis cytokinesis) are less connected, the dominant signal-transduction and developmental morphogenesis themes justify a cohesive label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071300","count":3},{"id":"GO:0007112","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0008344","count":2},{"id":"GO:0036120","count":2}]},{"hash":"1089710969824218839","title":"Lamellipodium-driven cell migration and actin dynamics","description":"These terms cohere around actin cytoskeleton remodeling and migratory protrusions: lamellipodium and microspike assembly, cell migration, and Rho GTPase signaling with GTPase activation, plus centrosome localization related to cell polarity. The dominant theme is actin-driven movement and dynamic cytoskeletal rearrangements driving migration, so the label reflects the cluster\u2019s core function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":5},{"id":"GO:0071539","count":3},{"id":"GO:0016477","count":3},{"id":"GO:1904424","count":2},{"id":"GO:0090630","count":2}]},{"hash":"17370027939487140","title":"Unknown","description":"The Top Terms include innate immune response and NF-kappaB-related signaling, but also mitotic cell cycle, adhesion, polarity, and various developmental terms with no single coherent function linking all proteins. The diversity of functions suggests heterogeneous roles rather than a shared pathway, so a specific label is not supported.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0000278","count":2},{"id":"GO:2000769","count":2},{"id":"GO:0007155","count":2}]},{"hash":"13131423333484590","title":"Ubiquitin-mediated proteolysis","description":"The GO terms cluster around ubiquitin-dependent protein catabolic processes, including ERAD, SCF-dependent degradation, polyubiquitination, and autoubiquitination, indicating a core function in tagging proteins for proteasomal degradation. Some terms like circadian rhythm regulation and brassinosteroid signaling suggest regulatory roles of ubiquitination in signaling pathways.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0030433","count":7},{"id":"GO:0042752","count":7},{"id":"GO:0000209","count":7},{"id":"GO:0051260","count":6}]},{"hash":"103661595715148105","title":"Axon Node/Paranode Localization and Signaling","description":"The top GO terms strongly point to proteins localizing to paranode/juxtaparanode regions of axons, indicating a theme of axon-domain organization. Additional terms emphasize signaling (ERK, Wnt) and cytoskeletal regulation (Rho GTPases) as well as endocytosis, consistent with coordinated signaling and membrane trafficking at axonal domains. The outlier term \u201cmale gonad development\u201d appears unrelated to the core neuronal functions and is likely annotation noise. Therefore, the label reflects a neuronal axon-domain organization and signaling function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008584","count":5},{"id":"GO:0070374","count":4},{"id":"GO:0071205","count":3},{"id":"GO:0002175","count":3},{"id":"GO:0090263","count":3}]},{"hash":"1459163929550542896","title":"Mitochondrial Respiratory Chain and ATP Synthesis","description":"The cluster centers on mitochondrial energy metabolism: electron transport chain activity (NADH to ubiquinone, cytochrome c oxidase), proton translocation and proton motive force\u2013driven ATP synthesis, and assembly of respiratory complexes, with additional hints of mitochondrial gene expression and apoptosis regulation linked to mitochondria.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":3},{"id":"GO:0090503","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006412","count":2},{"id":"GO:1902042","count":2}]},{"hash":"150249157566071839","title":"Vesicle exocytosis and synaptic plasticity regulators","description":"This cluster is enriched for GO terms tied to synaptic vesicle exocytosis and regulation of synaptic plasticity, pointing to a common role in neurotransmitter release and plasticity mechanisms. Additional terms on Ras/Rho signaling, PI3K-related insulin signaling, and acrosome reaction suggest a broader vesicle fusion/regulation theme across cell types. The lack of observed edges does not negate functional coherence; the terms collectively support a label focused on vesicle exocytosis and synaptic regulation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016079","count":3},{"id":"GO:0038028","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0045792","count":3}]},{"hash":"2277067806295560445","title":"Mitochondrial translation and protein import","description":"Most terms point to mitochondria: translation and protein import into the mitochondrial matrix are core mitochondrial processes, and porphyrin- and cobalamin-related biosynthesis align with mitochondrial cofactor metabolism. While some terms (e.g., musculoskeletal/neuromuscular processes, buoyancy regulation) appear less directly linked, they do not override the dominant mitochondrial theme. This cluster likely represents modules of mitochondrial protein synthesis machinery and import coupled with related metabolic pathways.","confidence":"Medium","size":20,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0030150","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0070584","count":1},{"id":"GO:0050881","count":1}]},{"hash":"1763718831504202114","title":"Mitochondrial Tetrapyrrole Biosynthesis","description":"Top GO terms indicate heme, chlorophyll, and protoporphyrinogen biosynthesis, i.e., tetrapyrrole production, alongside mitochondrial processes such as calcium homeostasis, ATP synthase assembly, and translation. This points to a cohesive theme of tetrapyrrole metabolism tied to mitochondrial function, with some plant-specific annotations present. ","confidence":"High","size":20,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006783","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0051560","count":2},{"id":"GO:0033615","count":1},{"id":"GO:0010082","count":1}]},{"hash":"1010237360599732886","title":"Steroid Hormone Biosynthesis and Reproductive Development","description":"These GO terms cluster around hormone biosynthesis (prostaglandin, bile acid, testosterone, brassinosteroid) and reproductive development (uterus development, maternal process involved in parturition), with vitamin D response and cell cycle regulation as supporting themes; some outliers (alkaloid/camphor catabolic processes) are present but not dominant.","confidence":"Medium","size":20,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":16},{"id":"GO:0001516","count":15},{"id":"GO:0033280","count":15},{"id":"GO:1900087","count":15},{"id":"GO:0010268","count":15}]},{"hash":"1384450784497832342","title":"Ubiquitin-dependent immune cell differentiation","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic process and several immune system development terms (germinal center formation, dendritic cell differentiation, pro-T cell differentiation, memory T cell differentiation). A few terms refer to distal tubule morphogenesis and skeletal muscle development, which may reflect broader roles or annotation noise, but the strongest signal ties ubiquitin-mediated proteolysis to immune cell maturation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0002467","count":6},{"id":"GO:2001200","count":6},{"id":"GO:1900477","count":6},{"id":"GO:0072156","count":6}]},{"hash":"300522100417319722","title":"Developmental Signaling and Tissue Development","description":"This cluster is dominated by GO terms tied to developmental processes: midbrain development, Wnt signaling pathway, and biomineral tissue development, along with multicellular organism growth. These point to a cohesive theme of developmental signaling guiding tissue formation and organogenesis. Other terms reflect regulatory roles, including transcriptional repression and immune/coagulation modulation, which may participate in developmental remodeling or context-specific regulation, but the core signal appears developmental.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":8},{"id":"GO:0030194","count":6},{"id":"GO:0031214","count":6},{"id":"GO:0050830","count":6}]},{"hash":"168667977957084544","title":"Ubiquitin-Dependent Immune Signaling in B Cells","description":"The top GO terms point to ubiquitin-dependent protein catabolism and ubiquitination together with immune signaling\u2014innate immunity, B cell receptor signaling, and germinal center formation\u2014highlighting a theme of ubiquitin-regulated immune signaling in B cells. Additional terms around JNK cascade regulation and vitamin D response support coordinated signaling and immune modulation, while some tissue-specific terms may reflect broader pleiotropy rather than core cluster function. Overall, the cluster appears to center on ubiquitin-driven regulation of B cell immune signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0045087","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0046328","count":4},{"id":"GO:0051260","count":4}]},{"hash":"2151665073840625951","title":"Proteoglycan Biosynthesis and Sulfation","description":"The cluster is enriched for glycosaminoglycan biosynthesis terms (heparan sulfate and chondroitin sulfate) and sulfation-related processes (protein sulfation, sulfate assimilation), pointing to a core theme of proteoglycan production and post-translational modification. Additional terms related to xenobiotic metabolism and thyroid hormone sulfation fit with sulfation-dependent detoxification and hormonal processing, while the T cell receptor signaling term may be a secondary association. ","confidence":"Medium","size":20,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":9},{"id":"GO:0035690","count":7},{"id":"GO:0015012","count":6},{"id":"GO:0006805","count":6},{"id":"GO:0030206","count":6}]},{"hash":"317267312072392350","title":"Vertebrate heart and nervous system GPCR signaling","description":"The cluster highlights heart development and cardiac muscle contraction, along with spinal cord development and sensory-related functions like sound perception, suggesting vertebrate cardiovascular and nervous system development. The shared thread appears to be GPCR signaling pathways (including internalization and PI3K/AKT signaling) that could influence both heart and nervous system processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0051262","count":4},{"id":"GO:0006924","count":4},{"id":"GO:0002031","count":4}]},{"hash":"1852473169511762026","title":"Innate Immunity and Organogenesis","description":"GO terms show strong signals for innate immune responses (defense against Gram-positive bacteria, response to lipopolysaccharide, leukocyte migration, complement activation via lectin pathway) alongside developmental processes (midbrain development, pancreas morphogenesis, endothelial barrier establishment, multicellular organism growth). The cluster appears to mix immune defense with organ development signals, and with no edges connecting proteins, the theme is best captured by a combined label rather than a single pathway. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0030901","count":11},{"id":"GO:0035264","count":11},{"id":"GO:0050830","count":10},{"id":"GO:0061113","count":10}]},{"hash":"158566978770275686","title":"MAPK and Rho GTPase signaling regulation","description":"These proteins cluster around the regulation of intracellular signaling pathways, notably ERK/MAPK cascades and Rho/Rac GTPase activity, along with receptor internalization and related trafficking processes. The shared theme is modulation of signaling and trafficking rather than a single pathway, justifying a label focused on signaling regulation and GTPase control.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0050714","count":2},{"id":"GO:0001938","count":2},{"id":"GO:0009303","count":2}]},{"hash":"2234719776020645417","title":"Cardiac and retinal GPCR-cAMP signaling","description":"This cluster\u2019s top GO terms cluster around GPCR-mediated signaling: activation of adenylate cyclase, cAMP signaling, and Ca2+ release, along with regulation of GTPase activity. The presence of heart development, regulation of cardiac muscle contraction, and opsin-mediated signaling with visual perception suggests a shared signaling theme in both cardiac and retinal systems. Thus, a concise label tying GPCR-cAMP/Ca2+ signaling to heart and retina best reflects the predominant functions.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0043950","count":9},{"id":"GO:0051281","count":9},{"id":"GO:0007190","count":9},{"id":"GO:0022400","count":9}]},{"hash":"80660021772287143","title":"Metal and oxidative stress response","description":"The cluster shows multiple GO terms tied to cellular responses to diamide and various metals (copper, cadmium, arsenite) as well as unfolded protein response, pointing to a common theme of stress-induced cellular response and protein quality control. A transcription-related term is present but likely reflects broader regulatory roles. Overall, the dominant pattern is metal/oxidative stress response, justifying this label; the other terms (B cell signaling, meiosis) are less central and may reflect annotation noise. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072738","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0034620","count":2},{"id":"GO:0071280","count":2},{"id":"GO:0071276","count":2}]},{"hash":"1332828561991001663","title":"Endocytosis and vesicle trafficking","description":"The GO terms cluster around endocytic pathways (GPCR internalization, clathrin-dependent and ubiquitin-dependent endocytosis) and vesicle exocytosis/priming (synaptic vesicle exocytosis, catecholamine secretion, acrosome reaction), indicating a shared role in vesicle trafficking and regulated secretion across cell types. A link to Rho signaling may relate to endocytic dynamics, reinforcing the vesicle cycling theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0002031","count":5},{"id":"GO:0072583","count":5},{"id":"GO:0016079","count":4},{"id":"GO:0007340","count":4}]},{"hash":"1402769171220925055","title":"Placental and Embryonic Morphogenesis","description":"The top GO terms cluster tightly around embryonic development and tissue morphogenesis, including placental development, endocrine system development, mesoderm formation, left/right patterning, cartilage morphogenesis, and EMT-related processes in the heart/cushion formation. This suggests the proteins work together in early development and placental formation, supporting a label that emphasizes placental and embryonic morphogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060806","count":16},{"id":"GO:0035270","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060707","count":16},{"id":"GO:0060972","count":16}]},{"hash":"336188530783252276","title":"Embryonic heart, placenta, and skeletal development regulators","description":"The cluster centers on transcriptional regulation during embryogenesis, with GO terms for DNA-templated transcription and RNA Pol II\u2013mediated transcriptional control, plus developmental processes such as heart development, left-right patterning, cartilage/bone morphogenesis, and placental/ trophoblast differentiation. This suggests a coherent set of transcription factors guiding early organogenesis across cardiac, skeletal, and placental lineages.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0060707","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1135188878316719240","title":"Ubiquitin-Dependent ERAD Regulation","description":"Cluster proteins appear centered on the ubiquitin-proteasome system, especially ER-associated degradation (ERAD) and deubiquitination, including negative regulation of ERAD and K48-linked deubiquitination. Additional terms touch on nuclear envelope reassembly, lipid droplet organization, and regulatory effects on NF-kappaB signaling, cell death, and chromosome dynamics, suggesting a cohesive module that governs proteostasis via ubiquitin signaling with some intersecting roles in cellular organization. High","confidence":"","size":19,"edges":169,"triangles":935,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":8},{"id":"GO:0016579","count":6},{"id":"GO:0031468","count":5},{"id":"GO:0034389","count":5},{"id":"GO:0007253","count":5}]},{"hash":"1478755691523715191","title":"Ubiquitin-Dependent Proteolysis and Cell Cycle","description":"The GO terms center on ubiquitination and proteasome-mediated protein degradation, including ubiquitin-dependent degradation (SCF and APC/C pathways), ERAD, autoubiquitination, and specific ubiquitin linkages (K6, K11). Coupled with cell division terms such as APC/C-dependent catabolic processes, the cluster reflects coordinated protein turnover during the cell cycle, with a signaling link to NF-kappaB activation. This cohesive theme makes the label representative of the cluster\u2019s function.","confidence":"High","size":19,"edges":7,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0016567","count":8},{"id":"GO:0030433","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0051301","count":7}]},{"hash":"1240512050889714463","title":"Embryonic organ morphogenesis","description":"Based on the prominent embryonic development and morphogenesis terms across diverse organs (heart/outflow tract, eye, hindlimb, placenta, habenula, prostate), with supporting hormone signaling involvement, suggesting a cluster of proteins involved in broad embryonic organ formation rather than a single tissue-specific process.","confidence":"High","size":19,"edges":64,"triangles":62,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":11},{"id":"GO:0007507","count":10},{"id":"GO:2000288","count":10},{"id":"GO:0060527","count":10},{"id":"GO:0030520","count":10}]},{"hash":"1509824934745844160","title":"ECM Adhesion and Angiogenesis Signaling","description":"The cluster is enriched for integrin-mediated adhesion, cell-matrix adhesion, and collagen fibril organization, pointing to extracellular matrix (ECM) interactions. The presence of GO terms for VEGF signaling and development (multicellular organism development, keratinocyte differentiation, myelination in PNS) suggests a role in angiogenesis and tissue morphogenesis driven by ECM\u2013cell signaling. Minor terms like response to manganese and an obsolete oxidation-reduction term are less central. Overall, the shared theme is ECM adhesion signaling coordinating development and vascular formation.","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0033631","count":5},{"id":"GO:1900748","count":5},{"id":"GO:0007160","count":4},{"id":"GO:0007275","count":4}]},{"hash":"2047775637187225653","title":"Metabolic and Immune Stress Responses","description":"This cluster combines metabolic signaling (response to amino acid, insulin stimulus, nitrogen utilization) with immune/inflammatory cues (lipopolysaccharide response, foam cell differentiation), plus toxin/ethanol responses and tissue remodeling signals (organ regeneration, regulation of fibroblast proliferation, cardiac muscle relaxation), pointing to a general program of metabolic-immune stress signaling linked to remodeling.","confidence":"Medium","size":19,"edges":16,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0031100","count":4},{"id":"GO:0043200","count":4},{"id":"GO:0032869","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0009636","count":4}]},{"hash":"2200546110821682263","title":"Neural transmission and synaptic adhesion","description":"The top GO terms point to neural signaling and synapse-related processes: paranodal junction assembly, transmission of nerve impulse, AMPA receptor regulation, and cell-adhesion interactions, all of which fit neural communication and synaptic organization. There are a few non-neural terms included (visual perception, GI epithelium maintenance, complement activation) that may reflect broader expression, but the core theme is neural signaling and synaptic structure.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":5},{"id":"GO:2001046","count":4},{"id":"GO:0007601","count":4},{"id":"GO:2000311","count":4},{"id":"GO:0019226","count":3}]},{"hash":"1062319320842229378","title":"Organelle ribosome biogenesis and RNA processing","description":"The top GO terms point to mitochondrial RNA processing, mitochondrial large ribosomal subunit assembly, chloroplast rRNA processing, and ribosome biogenesis, with links to cellular respiration and cytochrome complex assembly. This pattern suggests proteins functioning in organellar gene expression and energy production, i.e., mitochondria and chloroplasts. Confidence reflects a cohesive theme across the terms.","confidence":"High","size":19,"edges":38,"triangles":15,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000963","count":2},{"id":"GO:1902775","count":2},{"id":"GO:1901259","count":2},{"id":"GO:0045333","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1934474931791100318","title":"Spliceosome-driven mRNA processing and stability","description":"This cluster is dominated by GO terms describing spliceosome-mediated mRNA splicing (both positive and negative regulation), splice site recognition, and mRNA stabilization/modification, pointing to a cohesive module of post-transcriptional regulation. The presence of translation initiation factor 4F complex assembly suggests a link to translation initiation, but the central theme remains mRNA processing and fate control.","confidence":"High","size":19,"edges":164,"triangles":863,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048025","count":15},{"id":"GO:0010610","count":15},{"id":"GO:0045292","count":14},{"id":"GO:1905663","count":13},{"id":"GO:0097010","count":13}]},{"hash":"860047774626003534","title":"Gene Expression and DNA Maintenance","description":"The proteins cluster around nucleic acid processing and genome regulation, with frequent GO terms for mRNA splicing, DNA-templated transcription, and mismatch repair, complemented by signaling regulators (protein serine/threonine kinase activity and autophosphorylation) and a xenobiotic stress response. This combination suggests a set of factors coordinating gene expression and genome maintenance, with additional roles in cellular signaling and trafficking that reflect broader regulatory functions.","confidence":"Medium","size":19,"edges":26,"triangles":7,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0035690","count":4},{"id":"GO:0071902","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0006298","count":3}]},{"hash":"588406030474877514","title":"T cell activation and IL-27-STAT signaling","description":"The cluster\u2019s top GO terms center on adaptive immune signaling: IL-27\u2013mediated signaling, STAT tyrosine phosphorylation, TH2 cytokine production, and T cell receptor signaling. While developmental pathways (kidney, nervous system, myoblast fusion) and other signaling routes appear, the strongest signals are related to T cell activation and cytokine response, suggesting a cohesive immune-signaling theme.","confidence":"High","size":19,"edges":166,"triangles":887,"max_degree":18,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0070106","count":10},{"id":"GO:0042517","count":10},{"id":"GO:0035745","count":10},{"id":"GO:0050852","count":9},{"id":"GO:0001822","count":9}]},{"hash":"992036273721345524","title":"Ubiquitin-mediated proteolysis and NF-\u03baB signaling","description":"Top GO terms are dominated by various ubiquitin linkages (K48, K63, K6, K11) and ubiquitin-dependent protein degradation (ERAD), with additional links to NF-\u03baB and TNF signaling, indicating a cohesive module of ubiquitin-tag\u2013driven protein turnover and immune signaling.","confidence":"High","size":19,"edges":51,"triangles":72,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070936","count":12},{"id":"GO:0051865","count":12},{"id":"GO:0085020","count":11},{"id":"GO:0042787","count":10},{"id":"GO:0043123","count":10}]},{"hash":"2249066027901239551","title":"ER\u2013mitochondria stress and innate immune signaling","description":"The GO terms cluster around ER lumen retention and protein transport, innate immune signaling and T cell\u2013related processes, and mitochondrial regulation (membrane potential and fission), suggesting a shared theme of ER\u2013mitochondria\u2013immune stress response rather than a single narrow function. Some terms about cold/food response reflect broader stress adaptation within this network.","confidence":"Medium","size":19,"edges":38,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006621","count":3},{"id":"GO:0002369","count":3},{"id":"GO:0070231","count":3},{"id":"GO:0010204","count":3},{"id":"GO:0015031","count":3}]},{"hash":"2137269450997044968","title":"Immune signaling and cytoskeletal dynamics","description":"The cluster centers on immune-related signaling pathways (ephrin receptor and T cell receptor signaling) together with actin cytoskeleton remodeling (actin branching, podosome assembly, small GTPase signaling). This combination suggests coordinated cell signaling and rapid cytoskeletal changes, typical of immune cell activation and movement. While there are also broader developmental signals (Wnt, neuron projection development) and apoptosis, the strongest theme is immune signaling linked to dynamic cytoskeletal control.","confidence":"Medium","size":19,"edges":10,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048013","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0090135","count":7},{"id":"GO:0071803","count":7},{"id":"GO:0007264","count":7}]},{"hash":"1547606201153722857","title":"Embryonic organ morphogenesis and transcriptional regulation","description":"These proteins show enrichment for embryonic development and organ morphogenesis across multiple tissues (eye, pancreas, pituitary, lung, digestive tract, habenula, ureteric bud), along with transcriptional regulation by RNA polymerase II. The combination of specific organogenesis terms with Pol II\u2013mediated transcription suggests a coordinated developmental gene-expression program rather than a single tissue-specific function. Confidence: Medium","confidence":"","size":19,"edges":123,"triangles":345,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0000122","count":9},{"id":"GO:0048048","count":8},{"id":"GO:0090190","count":8},{"id":"GO:0031018","count":8}]},{"hash":"1441837608845173745","title":"Innate Immune Signaling and Antiviral Regulation","description":"The cluster is dominated by innate immune response and negative regulation of viral genome replication terms, pointing to antiviral defense as the core function. Other enriched terms (ephrin signaling, PDGF, retinoic acid response, and mammary gland morphogenesis) suggest related signaling and developmental processes, but the strongest signal remains innate immunity and antiviral regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0045071","count":5},{"id":"GO:0009636","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0045793","count":3}]},{"hash":"1923666753053616839","title":"Endothelial angiogenesis and intracellular trafficking","description":"The cluster centers on endothelial-specific processes such as endothelial tube lumen extension and negative regulation of sprouting angiogenesis, while also highlighting intracellular transport (ER-Golgi retrograde transport and positive regulation of intracellular protein transport) and protein regulation (ubiquitination, NF-kappaB signaling). This combination suggests a cohesive theme around endothelial angiogenesis coupled with vesicle trafficking and protein regulation.","confidence":"High","size":19,"edges":74,"triangles":111,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043124","count":6},{"id":"GO:0055091","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0010628","count":6},{"id":"GO:0035264","count":5}]},{"hash":"483110925873805012","title":"Neural sensation and dopaminergic signaling","description":"This cluster is dominated by GO terms related to neural sensing and signaling: sensory perception of pain, visual perception/learning, and dopaminergic synaptic transmission, plus cocaine-related behavioral responses and ERK cascade regulation. The presence of temperature-related responses likely reflects neural thermoregulatory signaling. A non-neural term (heart development) appears, but the majority of terms point to neural processing and behavioral output, supporting a label around neural sensation and dopaminergic signaling.","confidence":"High","size":19,"edges":43,"triangles":18,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0071380","count":11},{"id":"GO:0007507","count":11}]},{"hash":"1878510151907130592","title":"Pain-Linked GPCR Signaling and Cardio-Visual Development","description":"The cluster centers on GPCR-mediated signaling that activates adenylate cyclase, with strong associations to pain perception, thermogenesis, and cardiovascular regulation, plus developmental terms for retina and heart. The inclusion of electron transport and temperature-response terms reinforces a metabolic and signaling theme operating across nociception, energy use, and organ development.","confidence":"High","size":19,"edges":3,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0007190","count":11},{"id":"GO:0010579","count":11},{"id":"GO:0002024","count":11},{"id":"GO:0045777","count":11}]},{"hash":"1549609358834843819","title":"Nucleotide biosynthesis and salvage","description":"The Top GO terms cluster around deoxyribonucleoside salvage, dGTP and TMP biosynthesis, and related pyrimidine/nucleoside metabolism, indicating a shared function in nucleotide production and reuse. A mitochondrial electron transport term appears but the dominant pattern is nucleotide metabolism, supporting a concise label.","confidence":"High","size":19,"edges":169,"triangles":935,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006230","count":3},{"id":"GO:0071897","count":3},{"id":"GO:0006120","count":3},{"id":"GO:0006180","count":3},{"id":"GO:0016310","count":3}]},{"hash":"524951940077139924","title":"Neural development and synaptic vesicle trafficking","description":"The top GO terms point to nervous system development and regulation of synaptic vesicle exocytosis, plus endocytosis and retrograde vesicle transport between Golgi and ER, suggesting a cluster of proteins involved in neuronal maturation and the cycling of synaptic vesicles. Additional terms on actin remodeling and mechanical signaling reinforce a shared theme of dynamic trafficking and cytoskeletal changes underpinning neural connectivity.","confidence":"Medium","size":19,"edges":159,"triangles":777,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":4},{"id":"GO:0032729","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0007399","count":4},{"id":"GO:2000300","count":4}]},{"hash":"1494165079414928559","title":"B cell actin remodeling and signaling","description":"The terms converge on actin cytoskeleton dynamics (reorganization, branching, microspikes, podosomes) and regulators (Rho signaling, cell polarity) with immune signaling links (B cell receptor signaling, IL-2 production). This suggests a cohesive theme of actin-driven remodeling underpinning immune cell activation and signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":5},{"id":"GO:0050853","count":4},{"id":"GO:0030035","count":4},{"id":"GO:1900042","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1013089744419852288","title":"Organogenesis, neural development, and angiogenesis","description":"This cluster centers on developmental processes across multiple organs (neural, heart, kidney) and vascular growth. Top GO terms include angiogenesis, nervous system development (including peripheral nervous system) and nerve impulse transmission, BMP signaling, and organ development (heart and kidney), with supportive signaling like STAT activation and immune regulation via TLR9. The overall pattern suggests coordinated neural and organ development coupled with angiogenic signaling, making this a cohesive organogenesis-focused cluster.","confidence":"High","size":19,"edges":134,"triangles":528,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":10},{"id":"GO:0042517","count":10},{"id":"GO:0019226","count":9},{"id":"GO:0030513","count":9},{"id":"GO:0034164","count":9}]},{"hash":"758573219200487874","title":"Neuronal cytoskeleton dynamics and development","description":"This cluster is enriched for actin filament capping, microtubule-based movement, Rho/GTPase signaling, and neural development terms (neuron projection and spinal cord development), pointing to cytoskeleton remodeling driving neuronal differentiation and neurite outgrowth; transcriptional/epigenetic terms may reflect developmental regulation. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051016","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0034729","count":4},{"id":"GO:0051568","count":4},{"id":"GO:0031175","count":4}]},{"hash":"1901866371129978174","title":"Intracellular transport and signaling regulation","description":"The cluster is enriched for terms tied to intracellular protein transport and vesicle-related processes (intracellular transport, vesicle fusion with Golgi), along with regulatory roles in signaling pathways (negative regulation of ERK cascade, Notch signaling) and related cellular processes (mitotic cell cycle, non-motile cilium assembly). This combination points to a cohesive theme of coordinating trafficking with signaling regulation, rather than a single specific pathway. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0070373","count":3},{"id":"GO:0048280","count":2},{"id":"GO:1905515","count":2},{"id":"GO:0000278","count":2}]},{"hash":"440303580402048313","title":"Mitotic spindle organization and mitosis","description":"This cluster is enriched for GO terms tied to cell division, particularly mitosis and spindle dynamics: regulation of mitotic spindle organization, astral microtubule organization, metaphase/anaphase transition, and general cell division. While a couple of terms (like ribosome biogenesis) are more general, the dominant signals point to roles in spindle function and chromosome segregation during mitosis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000747","count":3}]},{"hash":"522315031096735092","title":"Metabolic Signaling and Lifespan Regulation","description":"The cluster\u2019s top GO terms span core metabolism (aerobic respiration, proton transport, insulin signaling and catabolic processes) and proteostasis (ubiquitin recycling, negative regulation of proteolysis) with a lifespan-related term (determination of adult lifespan). This suggests proteins involved in energy metabolism and growth signaling that can influence aging, rather than a single tight pathway. Some terms appear peripheral (e.g., obsolete pheromone maturation), indicating noise or pleiotropy, but the overarching theme is metabolic signaling linked to lifespan. ","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":3},{"id":"GO:0051289","count":3},{"id":"GO:0071432","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0010992","count":2}]},{"hash":"1860142962851884639","title":"Vision and retinal dopaminergic signaling","description":"This cluster is dominated by vision-related terms (visual learning, visual perception, retina development) and dopaminergic synaptic transmission, suggesting a focus on visual processing with dopamine signaling. ERK cascade regulation and cocaine-related behavioral response point to neural plasticity in reward/vision circuits. Some terms are less related, but overall the theme is visual system function with dopaminergic signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":18},{"id":"GO:0007601","count":18},{"id":"GO:0070374","count":18},{"id":"GO:0048148","count":18},{"id":"GO:0010759","count":18}]},{"hash":"1645931011112817466","title":"BMP-regulated craniofacial skeletal development","description":"This cluster centers on chondrocyte and osteoblast differentiation, palate and cranial skeleton morphogenesis, and mesoderm formation, all linked to BMP signaling and SMAD phosphorylation; regulatory transcription and miRNA transcription terms further support coordinated developmental control of craniofacial bone/cartilage formation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002062","count":5},{"id":"GO:0030513","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0045669","count":4}]},{"hash":"2191368740407429829","title":"Ubiquitin-dependent innate immune signaling","description":"The top GO terms combine ubiquitination processes (ubiquitin-dependent protein catabolic process, protein ubiquitination, ERAD) with innate immune and antiviral signaling (NF-kappaB, TNF, defense against virus). They also include regulation of RIG-I signaling and apoptotic processes, indicating a cohesive theme of ubiquitin-mediated control of antiviral responses and cell fate. This makes the label a good summary of the cluster's function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0045087","count":9},{"id":"GO:0051607","count":9},{"id":"GO:0016567","count":8},{"id":"GO:0030433","count":8}]},{"hash":"590147480319367407","title":"Embryonic Morphogenesis and Muscle Development","description":"The terms cluster around developmental and morphogenetic processes, notably skeletal muscle development/differentiation, and morphogenesis across multiple tissues (neural plate, outflow tract, post-anal tail). Additional terms point to cell adhesion and GTPase regulation involved in cytoskeletal remodeling during development. Together, they suggest a broad theme of embryonic morphogenesis with a focus on muscle lineage, hence this label. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034260","count":3},{"id":"GO:0034446","count":3},{"id":"GO:0048741","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0035914","count":2}]},{"hash":"704874874093710852","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0070433","count":2}]},{"hash":"1632746816410453193","title":"Dopaminergic Signaling and Thermogenesis","description":"The terms cluster around dopamine-mediated neural signaling (dopaminergic synaptic transmission, GPCR-adenylate cyclase activation) together with temperature- and metabolic-related responses (diet-induced thermogenesis, temperature stimulus) and related membrane potential and blood pressure regulation, suggesting a neuroendocrine module linking dopamine signaling with thermogenic/metabolic control.","confidence":"High","size":19,"edges":13,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0002024","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0007190","count":10},{"id":"GO:0001963","count":10}]},{"hash":"1503265106071247322","title":"Unknown","description":"The terms span diverse biological areas including Notch signaling regulation, blood coagulation, B cell differentiation, hormone response, metal transport, calcium homeostasis, serine biosynthesis, and LPS biosynthesis, with no clear single function tying the cluster together. Therefore a concise, representative label cannot be assigned beyond Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007386","count":4},{"id":"GO:0045747","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0002315","count":3},{"id":"GO:0097755","count":3}]},{"hash":"1103744002585164472","title":"Unknown","description":"The top GO terms span hepatocyte apoptosis, skin barrier formation (cornification), cardiac muscle development, and broad transport/polarity processes (axonal and mitochondrial transport, microtubule polarity). There isn\u2019t a single, cohesive biological function uniting these terms for this cluster, and several terms are tissue-specific or obsolete, so a clear representative label cannot be determined.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":6},{"id":"GO:0090343","count":5},{"id":"GO:0035105","count":5},{"id":"GO:0008090","count":5},{"id":"GO:0061436","count":5}]},{"hash":"1402004765593529136","title":"Dopamine GPCR signaling and receptor trafficking","description":"The top GO terms cluster around dopamine receptor\u2013mediated G protein signaling, endocytosis and receptor recycling, clathrin coat assembly, and endosome-to-postsynaptic membrane transport, pointing to a neuronal signaling module tied to dopamine receptor trafficking. A few miscellaneous terms (heme biosynthesis, mitochondrial complex assembly) seem less connected and likely represent background noise. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007212","count":2},{"id":"GO:0001921","count":2},{"id":"GO:0048268","count":2},{"id":"GO:0098887","count":2},{"id":"GO:0045807","count":2}]},{"hash":"1774198222935012102","title":"Inflammation-vascular stress signaling","description":"The dominant GO terms cluster around inflammatory responses (inflammatory response, response to lipopolysaccharide), vascular regulation (positive regulation of blood pressure, vasoconstriction), and temperature/metabolic stress (cellular response to temperature stimulus, diet-induced thermogenesis, electron transport chain), suggesting a common role in coordinating inflammatory vascular signaling and metabolic stress responses. While some terms (GPCR signaling, Rho pathway) reflect broader signaling connections, the core pattern points to inflammation-driven vascular and metabolic stress responses.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0045777","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0010579","count":9},{"id":"GO:0035025","count":8}]},{"hash":"2022068519487773127","title":"GPCR Signaling with Vascular and Immune Functions","description":"The most represented terms are GPCR internalization, PI3K/AKT signaling, platelet activation, and vasoconstriction, all pointing to GPCR-driven signaling influencing immune and cardiovascular function. Additional terms touch on T cell death and neural/sensory processes, suggesting broader signaling roles, but the core motif centers on GPCR-mediated communication impacting immune and vascular pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006924","count":3},{"id":"GO:0071625","count":3},{"id":"GO:1903760","count":2},{"id":"GO:0043491","count":2},{"id":"GO:0016126","count":2}]},{"hash":"818678104061239214","title":"Dopaminergic signaling and cortical interneuron migration","description":"The top GO terms indicate a clear focus on dopamine-related signaling (negative regulation of dopamine receptor signaling, dopamine transport, GPCR-mediated adenylate cyclase pathways) and a developmental/organizational aspect related to cortical GABAergic interneuron migration. While some terms (calcium release, muscle relaxation) are more general or ancillary, the dominant themes consistently point to neuronal signaling regulation and cortical interneuron development, justifying this combined label.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":19},{"id":"GO:0060160","count":18},{"id":"GO:0090075","count":18},{"id":"GO:0007194","count":18},{"id":"GO:0016998","count":18}]},{"hash":"688915976871151106","title":"Inflammation-driven vascular and pain signaling","description":"This cluster centers on inflammatory processes (inflammatory response, response to lipopolysaccharide) with associated vascular and pain-related signaling (vasoconstriction, blood coagulation, GPCR signaling, calcium release). The co-occurrence of pain perception and vascular regulation terms suggests a cohesive theme of immune-driven vascular and nociceptive signaling in the proteins\u2019 functions.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0045907","count":10},{"id":"GO:0032496","count":10},{"id":"GO:0035625","count":10},{"id":"GO:0006954","count":10}]},{"hash":"1335085519155887680","title":"GPCR Signaling and Second Messenger Regulation","description":"The top GO terms cluster around G protein-coupled receptor signaling, regulation of adenylate cyclase and calcium release, and downstream effects such as dopamine signaling and muscle relaxation, suggesting a theme of GPCR-triggered second messenger pathways (cAMP and Ca2+). Some terms (defense response, cell wall catabolic process) are less directly tied, but the dominant pattern supports signaling transduction.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035625","count":16},{"id":"GO:0051209","count":15},{"id":"GO:0042742","count":15},{"id":"GO:0060160","count":14},{"id":"GO:0090075","count":14}]},{"hash":"1828104827912652422","title":"Unknown","description":"The proteins show a highly heterogeneous set of functions, spanning epithelial polarity, various apoptotic processes, cell migration, mRNA processing, SNARE regulation, PARylation, and kinase activity regulation, with no single cohesive pathway uniting them.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":5},{"id":"GO:0097284","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0033028","count":5},{"id":"GO:0006397","count":5}]},{"hash":"251502398180260276","title":"Nucleotide Metabolism and DNA Replication Initiation","description":"This cluster is dominated by nucleotide metabolism terms (purine ribonucleotide interconversion, CDP biosynthesis, GTP metabolism, AMP salvage, ITP metabolism) and a related term for DNA replication initiation, suggesting proteins involved in nucleotide synthesis/turnover and replication readiness. ERAD and development terms appear less central, indicating broader functional diversity among the proteins.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097466","count":2},{"id":"GO:0015951","count":1},{"id":"GO:0046041","count":1},{"id":"GO:0046705","count":1},{"id":"GO:0006270","count":1}]},{"hash":"237037218972759634","title":"Axon Growth and Branching Regulation","description":"This cluster is dominated by neural development terms: negative regulation of axon extension, axonal fasciculation, and regulation of branching morphogenesis of a nerve, plus positive regulation of GTPase activity which relates to cytoskeletal dynamics guiding axon growth. While DNA-templated transcription and replication hint at general cellular processes, the strongest signal is axon growth/branching guidance, making this an appropriate label. Some terms (defense response, bone development) appear less connected and may reflect broader cellular roles, but the core theme remains neural morphogenesis and axon regulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030517","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0006260","count":3},{"id":"GO:2000172","count":3}]},{"hash":"1010153026060994168","title":"Histone acetylation and transcription regulation","description":"Most top GO terms center on histone acetylation (H4 and H2A) and regulation of DNA-templated transcription, pointing to a chromatin modification/transcription control module. A few transport and sensory terms are present but far less represented.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043981","count":3},{"id":"GO:0043982","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0043968","count":2},{"id":"GO:0043983","count":2}]},{"hash":"2123258183519558347","title":"Intracellular signaling and endosomal trafficking","description":"The terms indicate regulation of signaling pathways (positive regulation of peptidyl-serine phosphorylation; positive regulation of GTPase activity; TORC1 signaling) together with vesicle trafficking activities (early to late endosome transport) and associated processes like phagocytosis and mRNA stabilization. While development- and behavior-related terms (spinal cord development, multicellular organism growth, social behavior) are present, the core theme appears to be intracellular signal transduction coupled with endosomal trafficking, rather than a single enzymatic pathway. The lack of observed edges supports this as a broad functional category rather than a tightly connected module.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":4},{"id":"GO:0021510","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0038202","count":3}]},{"hash":"600436202979450365","title":"Embryogenesis and organ morphogenesis","description":"Based on the top GO terms, the proteins cluster around embryonic development and the formation of organs/tissues, including placenta-related differentiation, left/right patterning, EMT in cardiac cushion formation, cartilage morphogenesis, and endocrine system development. The cluster thus reflects broad developmental processes guiding tissue specification and morphogenesis in the embryo.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":18},{"id":"GO:0060972","count":18},{"id":"GO:0060806","count":18},{"id":"GO:0060536","count":18},{"id":"GO:0003198","count":18}]},{"hash":"1208143990126397423","title":"Complement and coagulation with endothelial barrier regulation","description":"This cluster centers on innate immune defense and vascular regulation, highlighted by GO terms for complement activation (classical and lectin), blood coagulation, and establishment of the endothelial barrier, plus extracellular matrix remodeling (collagen catabolic process). The presence of defense response to Gram-positive bacteria and signaling terms like Wnt further suggests coordinated immune-vascular signaling, justifying a label that emphasizes complement/coagulation alongside barrier maintenance.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":5},{"id":"GO:0051965","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0030574","count":4},{"id":"GO:0006958","count":4}]},{"hash":"1469095298693358252","title":"Membrane-Cytoskeleton Dynamics","description":"The GO terms highlight processes at the cell surface and cortex, such as plasma membrane repair, actin filament organization and mitotic contractile ring assembly, brush border assembly, and Golgi inheritance, plus membrane-initiated signaling (thrombin receptor) and sperm binding. This pattern suggests a common theme of membrane remodeling coordinated with the cytoskeleton and cell polarity, despite some broader developmental terms appearing. Overall, the cluster seems centered on membrane\u2013cytoskeleton dynamics.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001778","count":2},{"id":"GO:1902405","count":1},{"id":"GO:0021592","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0070493","count":1}]},{"hash":"1893576113444060383","title":"Axial mesoderm, skeletal, and ear development","description":"The top GO terms cluster around development of the axial mesoderm and skeletal system (axial mesoderm development, skeletal system development, ossification) as well as craniofacial/ear formation (middle ear morphogenesis, sensory perception of sound). Additional neural differentiation term (dopaminergic neuron differentiation) suggests broader developmental differentiation in neural lineages. The presence of translation-related terms likely reflects general cellular housekeeping rather than a distinct pathway, but the dominant theme is developmental programs in skeletal/ear and neural tissues.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0034463","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0001503","count":2},{"id":"GO:0006412","count":2}]},{"hash":"2214221288002882753","title":"Neuronal development and sensory signaling","description":"The top GO terms point to neural development (cerebellar granule cell differentiation) and sensory detection (pain and thermoception), with supporting signaling pathways (Wnt, GPCR-related) and growth/angiogenesis signals, suggesting a cluster centered on neural development and sensory signaling processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0050966","count":4},{"id":"GO:0035544","count":4},{"id":"GO:0050960","count":4}]},{"hash":"1994173539041800042","title":"Embryonic development and mesodermal morphogenesis","description":"The cluster is dominated by GO terms tied to embryogenesis, placenta/placental tissue differentiation, mesoderm formation, and tissue morphogenesis (cartilage, palate), plus patterning and EMT events in heart development. Together these point to a cohesive theme of early development and organ/tissue formation, rather than a specific metabolic function.","confidence":"High","size":19,"edges":6,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":18},{"id":"GO:0060806","count":16},{"id":"GO:0035270","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060707","count":16}]},{"hash":"1821034727618104756","title":"Wnt/Hippo signaling in embryonic morphogenesis","description":"These proteins cluster around developmental signaling pathways and morphogenesis. The top terms include both positive and negative regulation of canonical Wnt signaling, hippo signaling, axial mesoderm formation, and cell morphogenesis, with supporting roles in apoptosis, keratinocyte differentiation, and DNA replication. Together they suggest coordination of embryonic tissue patterning and cell fate during development, rather than a single, narrow function.","confidence":"High","size":18,"edges":51,"triangles":51,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000902","count":9},{"id":"GO:0006260","count":9},{"id":"GO:0090263","count":8},{"id":"GO:0060044","count":7},{"id":"GO:0035329","count":7}]},{"hash":"819368489931657163","title":"Transcriptional Regulation and Chromatin Remodeling","description":"The cluster is dominated by GO terms tied to DNA-templated transcription, negative regulation of RNA polymerase II transcription, regulation of transcription preinitiation complex assembly, and chromatin remodeling, suggesting a core function in controlling transcription and chromatin state. Some tissue development terms are present but likely reflect downstream roles of transcription regulators. Confidence: High","confidence":"","size":18,"edges":61,"triangles":89,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0048298","count":12},{"id":"GO:0003290","count":12},{"id":"GO:0003289","count":12},{"id":"GO:0070384","count":11}]},{"hash":"955830831613667972","title":"Unknown","description":"The top GO terms are highly heterogeneous, including morphine response, photosynthesis, retinal rod development, male differentiation, and various regulatory processes, with no clear shared function tying the proteins together. Additionally, there are 0 edges among nodes, suggesting no cohesive interaction pattern; without a common theme, a specific functional label cannot be assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043278","count":6},{"id":"GO:0035955","count":5},{"id":"GO:0007091","count":5},{"id":"GO:1903646","count":5},{"id":"GO:0070301","count":5}]},{"hash":"432554046434957488","title":"RNA Splicing and mRNA Regulation","description":"The top GO terms cluster around spliceosome-mediated mRNA processing (positive regulation of mRNA splicing via spliceosome; cis splicing via spliceosome), mRNA stability and modification, and regulatory ncRNA silencing, with hints of translation initiation factor complex assembly. This points to a coherent functional module centered on RNA maturation and post-transcriptional regulation.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":15},{"id":"GO:0031047","count":15},{"id":"GO:0010610","count":13},{"id":"GO:1901407","count":10},{"id":"GO:0045292","count":10}]},{"hash":"2252348992211541628","title":"Developmental gene expression and protein regulation","description":"The cluster is enriched for GO terms related to regulating gene expression (positive regulation of transcription, translation; phosphorylation) and developmental processes (multicellular organism development, cell morphogenesis). The presence of proteasomal ubiquitin-dependent protein catabolic process suggests coordinated protein turnover during development, reinforcing a theme of tightly controlled gene expression and cellular remodeling in development. Some metabolic/other terms appear peripherally, but the dominant signals point to regulation of expression and development.","confidence":"High","size":18,"edges":133,"triangles":567,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045727","count":5},{"id":"GO:0016310","count":5},{"id":"GO:0019284","count":5},{"id":"GO:0009088","count":5},{"id":"GO:0006351","count":5}]},{"hash":"866171396772399908","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":92,"triangles":243,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:0034475","count":8},{"id":"GO:0071035","count":8},{"id":"GO:0000467","count":8}]},{"hash":"1694593463306545291","title":"Ubiquitin-Proteasome Regulation and Cell Cycle Control","description":"The top GO terms center on regulation of ubiquitin-mediated proteolysis (proteasomal degradation and deubiquitination), plus cell cycle processes (G2/M transition and chromosome condensation) and apoptosis. This points to a coherent cluster of proteins that modulate protein turnover and cell-cycle progression, with auxiliary links to transcription and immune signaling.","confidence":"High","size":18,"edges":21,"triangles":12,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":2},{"id":"GO:0043392","count":2},{"id":"GO:0016579","count":2},{"id":"GO:0042981","count":2},{"id":"GO:0044839","count":1}]},{"hash":"1163878402803100914","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by translation-related processes: translation itself, ribosomal large subunit assembly, tRNA wobble modification, and rRNA maturation, with also mitochondrial translation and related termination. This points to a cohesive theme centered on the protein synthesis machinery and ribosome assembly, across domains. Some peripheral terms (electron transport, bacteriochlorophyll biosynthesis) might reflect multifunctional proteins or annotation noise, but they do not override the core translation/ ribosome biogenesis signal.","confidence":"High","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0000027","count":3},{"id":"GO:0006120","count":2},{"id":"GO:0045226","count":2},{"id":"GO:0002098","count":2}]},{"hash":"331751214660905494","title":"Nuclear chromatin and meiotic regulation","description":"The GO terms cluster around nuclear functions: heterochromatin formation, nuclear import, mRNA transport, transcription regulation by RNA Pol III, and meiotic cell cycle control, suggesting a theme of chromatin-level and meiotic regulation within the nucleus, despite some terms that are less directly related.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0030466","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0006607","count":7},{"id":"GO:1903342","count":7},{"id":"GO:0045945","count":7}]},{"hash":"1058369769568662129","title":"Iron-Sulfur Cluster Biogenesis and Mitochondrial Translation","description":"The cluster shows notable enrichment for iron-sulfur cluster-related processes (assembly, iron homeostasis, maturation) alongside translation-related activities (general translation and mitochondrial translation, plus tRNA processing steps). This points to a cohesive module where Fe-S cluster biogenesis is linked to mitochondrial translation machinery and tRNA maturation, though a few outlier terms may reflect annotation noise.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0016226","count":2},{"id":"GO:0009399","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0070681","count":1},{"id":"GO:0032543","count":1}]},{"hash":"1625655437383745386","title":"Neural and Cardiovascular Development","description":"This cluster is enriched for neural development terms (cerebral cortex, brain, midbrain morphogenesis) and heart/vascular development, with supporting signals in DNA replication, G1/S cell-cycle progression, myoblast differentiation, and Rho signaling. The pattern points to proteins involved in organogenesis, especially neural and cardiac development, rather than a single narrow function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0021987","count":4},{"id":"GO:0060716","count":4},{"id":"GO:0071380","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0006260","count":3}]},{"hash":"1302856903956675221","title":"Vertebrate developmental transcriptional regulation","description":"This cluster combines transcriptional control by RNA polymerase II (including negative regulation of Pol II) with diverse tissue development terms (retina, osteoblasts, pituitary, placenta) and regeneration (liver), suggesting a group of proteins involved in coordinating transcriptional regulation during vertebrate development across multiple tissues rather than a single pathway.","confidence":"High","size":18,"edges":145,"triangles":695,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0060041","count":7},{"id":"GO:0002076","count":7},{"id":"GO:0002087","count":7},{"id":"GO:0097421","count":6}]},{"hash":"944570803420669087","title":"Negative Regulation of MAPK Signaling and Cerebellar Development","description":"This cluster centers on GO terms that describe inhibition or negative regulation of signaling pathways (notably the MAPK/ERK cascade, T cell receptor signaling, and insulin signaling) and on neural development processes such as Bergmann glial differentiation and cerebellar cortex formation, as well as regulation of axon regeneration. The combination suggests a cohesive theme around dampening signaling activity in neural development contexts, with broader implications for immune/metabolic signaling as well. Confidence: Medium.","confidence":"","size":18,"edges":138,"triangles":617,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070373","count":13},{"id":"GO:0000200","count":13},{"id":"GO:0050860","count":13},{"id":"GO:0060020","count":9},{"id":"GO:0021697","count":9}]},{"hash":"1142811369009088135","title":"Unknown","description":"The top terms span animal development (uterus, female gonad, maternal parturition), hormone biosynthesis/response (prostaglandin, brassinosteroid homeostasis, vitamin D response), and broad xenobiotic/metabolic catabolic processes (carbazole, alkaloid, camphor) along with cell-cycle regulation, a mix that lacks a single cohesive function. This suggests no clear shared theme for a concise, representative label.","confidence":"","size":18,"edges":14,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":13},{"id":"GO:0008585","count":13},{"id":"GO:0001516","count":13},{"id":"GO:0046232","count":13},{"id":"GO:0033280","count":12}]},{"hash":"774841237365667410","title":"Motor neuron axon guidance and migration","description":"The top GO terms cluster around motor neuron development, especially axon guidance and axonogenesis in the peripheral nervous system, and neuron migration (GO:0008045, GO:0048936, GO:0097477), with supporting roles from cell-matrix adhesion. Some terms (antibiotic biosynthesis, lung development) seem unrelated noise, but the dominant theme is motor neuron axon pathfinding and migration.","confidence":"High","size":18,"edges":34,"triangles":6,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0017000","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0007160","count":4},{"id":"GO:0070527","count":4}]},{"hash":"748916110636542267","title":"Bacterial antibiotic and cofactor biosynthesis","description":"This cluster centers on GO terms for antibiotic biosynthesis and response, along with biotin and menaquinone biosynthetic processes, lipoylation, and tRNA methylation, plus a regulatory/transcriptional angle and xenobiotic response. The combination suggests a cohesive theme of bacterial secondary metabolism focused on antibiotic production and cofactor assembly/modification, with related metabolic regulation.","confidence":"Medium","size":18,"edges":143,"triangles":665,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0009102","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0030488","count":3}]},{"hash":"1256528026362090266","title":"Embryonic brain and endocrine organ development","description":"Reason: The top GO terms cluster around embryonic development of multiple organ systems, notably neural tissues (pituitary, midbrain, hypothalamus, roof of mouth origin) as well as endocrine organs (endocrine pancreas) and early embryogenesis (primitive streak, digestive tract morphogenesis). This suggests a broad embryonic organogenesis program rather than a single tissue-specific pathway.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":10},{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":8},{"id":"GO:0031018","count":7},{"id":"GO:0032496","count":7}]},{"hash":"61727138448742199","title":"Developmental signaling and morphogenesis","description":"The terms point to developmental processes (multicellular organism development, skeletal system morphogenesis, male gonad development) with strong links to growth factor signaling (EGF and TGF-beta responses), kinase and GTPase signaling, and cytoskeletal remodeling (actin depolymerization), suggesting a cohesive theme of development guided by signaling and structural changes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0048705","count":3},{"id":"GO:0071364","count":3},{"id":"GO:0045657","count":3},{"id":"GO:0008584","count":3}]},{"hash":"898901047665907521","title":"Cerebellar Neurodevelopment and Bergmann Glia Differentiation","description":"This cluster is dominated by terms related to cerebellar cortex formation, neuron development, axon regeneration, and Bergmann glial cell differentiation, suggesting a cohesive theme of cerebellar neurodevelopment and glial specification. The kinase/cell-cycle related terms and kinetochore localization appear as ancillary annotations but do not define the primary functional cluster.","confidence":"High","size":18,"edges":92,"triangles":169,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":10},{"id":"GO:0045736","count":10},{"id":"GO:0048666","count":8},{"id":"GO:0035335","count":8},{"id":"GO:0032435","count":8}]},{"hash":"2227907630147325671","title":"Vertebrate embryogenesis and organogenesis","description":"This cluster centers on embryonic development across multiple vertebrate tissues, with dominant terms covering heart development, inner ear development, cartilage/cranial skeleton morphogenesis, hindlimb morphogenesis, pituitary and telencephalon regionalization, and primitive streak formation, pointing to a cohesive theme of vertebrate embryogenesis and organ morphogenesis. The negative regulation of transcription by RNA polymerase II likely reflects regulatory control during development rather than a single pathway.","confidence":"High","size":18,"edges":12,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0007507","count":5},{"id":"GO:0090009","count":5},{"id":"GO:0048839","count":5},{"id":"GO:0008584","count":5}]},{"hash":"1398305719041639464","title":"Nervous system development and synaptic organization","description":"The cluster centers on neural development and synaptic function: myelination, ROBO (Roundabout) axon guidance, positive regulation of synapse assembly, synapse organization, and transmission of nerve impulse, along with peripheral nervous system and nervous system development. Clustering of voltage-gated sodium channels also fits nerve signaling. While neutrophil clearance and angiogenesis appear less directly related, they may reflect broader developmental or neurovascular interactions. Overall, the theme is neuronal development and synaptic wiring.","confidence":"High","size":18,"edges":13,"triangles":1,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042552","count":12},{"id":"GO:0035385","count":12},{"id":"GO:0051965","count":12},{"id":"GO:0050808","count":12},{"id":"GO:0045162","count":12}]},{"hash":"828079415106618605","title":"Prokaryotic cell division and ribosome biogenesis","description":"This cluster shows strong signals for ribosome biogenesis, tRNA modification, and core cell-cycle processes (cell division, cell cycle, septum assembly), indicating a prokaryotic program coordinating protein synthesis with division. Some stress-related terms are present, but the dominant theme is growth and division machinery.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051260","count":13},{"id":"GO:0090529","count":10},{"id":"GO:1901001","count":10},{"id":"GO:0051301","count":10},{"id":"GO:0042274","count":10}]},{"hash":"1070057765355394277","title":"Neuroimmune Axon Guidance and Synapse Formation","description":"The top GO terms mix innate immune signaling (TLR pathways, lipopolysaccharide response, defense against Gram-positive bacteria) with neural development processes (axonal fasciculation, corpus callosum development, positive regulation of synapse assembly) and cytoskeletal remodeling (actin filament severing). This points to a coordinated theme where immune signaling interfaces with axon pathfinding and synapse formation, possibly reflecting microglial or immune-mediated modulation of neural development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":4},{"id":"GO:0007413","count":3},{"id":"GO:0051014","count":3},{"id":"GO:0034134","count":3},{"id":"GO:0034162","count":3}]},{"hash":"280963074506481725","title":"Neural development and neurotrophin signaling","description":"The top terms cluster around neural development and signaling, including neuron projection development, neuronal and glial apoptotic processes, and neurotrophin TRK receptor signaling, with accompanying cytoskeletal regulation (Rho signaling) and cell adhesion. A nicotine response term further supports neuronal signaling involvement. Together these suggest a functional emphasis on neural development and associated signaling pathways rather than muscle-specific processes. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007155","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0035094","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1350880726769231743","title":"NF-kB Signaling and Developmental Transcription","description":"These proteins show enrichment for positive regulation of canonical NF-kappaB signaling, transcriptional control, and developmental processes, alongside cell-cycle related terms such as mitotic cell cycle and cytokinesis. The convergence on NF-kB\u2013driven transcription, development (forebrain and multicellular organism development), and cell cycle regulation suggests a module coordinating signaling, transcription, and proliferation during development and injury responses.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043123","count":4},{"id":"GO:0032465","count":4},{"id":"GO:0010800","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1666394362847250227","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster's top GO terms are dominated by ubiquitination and protein catabolic processes (ubiquitin-dependent protein degradation, K48- and K63-linked ubiquitination, ERAD, and autoubiquitination), indicating a coherent theme around ubiquitin-mediated proteolysis and quality control. Some immune-related terms (T cell homeostasis, germinal center regulation) and antiviral response appear, suggesting broader regulatory connections, but the central signal is ubiquitin signaling guiding protein turnover.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0070936","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0051865","count":7},{"id":"GO:0033280","count":6}]},{"hash":"1751036027032601583","title":"Female reproductive development and prostaglandin signaling","description":"The cluster is dominated by GO terms related to uterus development, female gonad development, maternal processes in parturition, and prostaglandin biosynthesis, indicating a coherent theme around female reproductive development and signaling that controls pregnancy and parturition. Some terms such as brassinosteroid homeostasis and camphor/alkaloid catabolic processes appear as outliers or cross-species annotations, suggesting annotation noise rather than true functional coupling, but they do not overwhelm the reproductive-related signal.","confidence":"Medium","size":18,"edges":81,"triangles":127,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":16},{"id":"GO:0008585","count":16},{"id":"GO:0001516","count":15},{"id":"GO:0033280","count":15},{"id":"GO:1900087","count":15}]},{"hash":"47077912076927540","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"This cluster is driven by GO terms linking ubiquitination to immune signaling: ubiquitin-dependent protein catabolic process, protein autoubiquitination, and K6-linked ubiquitination, along with innate immune response, NF-kappaB-inducing kinase activation, and TNF-mediated signaling. Together these terms suggest a module where ubiquitin modification modulates innate immune and inflammatory pathways, including NF-\u03baB and TNF signaling, with some related but obsolete histone modification terms likely annotation noise. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:1901253","count":9},{"id":"GO:0051865","count":9},{"id":"GO:0045087","count":9},{"id":"GO:0085020","count":8}]},{"hash":"406399479090927116","title":"Synaptic organization and development cues","description":"The top GO terms cluster around synapse-related organization (AMPA receptor clustering, GKAP clustering, immunological synapse formation), suggesting a core function in synapse architecture. Additional terms reference development (thymus, cranial skeletal system) and broad cellular processes (DNA-templated transcription, spindle assembly), indicating some degree of heterogeneity or multi-functionality. Overall, the most representative label points to synaptic organization with developmental context.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051225","count":3},{"id":"GO:1990859","count":3},{"id":"GO:1903760","count":3},{"id":"GO:2001205","count":3}]},{"hash":"773202968256269644","title":"Embryonic mesoderm patterning and skeletal development","description":"The top GO terms point to embryonic development programs: mesodermal cell fate specification, anterior/posterior and dorsal/ventral patterning, organ induction, and skeletal-related morphogenesis (cartilage, joints, metanephros, gonad). Translation appears only as a minor background process, not the core signal. Together they suggest a cluster of proteins involved in embryonic mesoderm patterning and skeletal formation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0007501","count":1},{"id":"GO:0001759","count":1},{"id":"GO:0009952","count":1},{"id":"GO:0008584","count":1}]},{"hash":"686389424334652547","title":"Inflammation-driven vascular and coagulation responses","description":"These proteins cluster around inflammatory signaling and vascular function. Prominent GO terms include inflammatory response and response to lipopolysaccharide, pain perception, vasoconstriction regulation, and blood coagulation, pointing to endotoxin-triggered inflammatory vasculature and hemostatic processes. Modulatory GPCR signaling and smooth muscle relaxation/adenylate cyclase regulation suggest coordinated control of vascular tone and muscle response during inflammation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045907","count":12},{"id":"GO:0032496","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0006954","count":12},{"id":"GO:0045986","count":12}]},{"hash":"58492468336610399","title":"Neurovascular development and signaling","description":"Based on the top GO terms, this cluster centers on brain development and neural processes, alongside vascular/endothelial signaling (VEGF pathways, endothelial cell migration) and receptor-mediated signaling (thrombin-activated receptor, Ras). Additional terms touch synaptic vesicle docking, thymus development, and immune/endocrine regulation (IL-4 production, cortisol biosynthesis). The convergence of neural development with vascular and immune signaling suggests a neurovascular development theme, hence this label.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0038033","count":3},{"id":"GO:0018105","count":3},{"id":"GO:0032753","count":3},{"id":"GO:2000064","count":3}]},{"hash":"1111404910487428187","title":"Complement and coagulation in vascular inflammation","description":"The cluster shows strong signals for immune and plasma cascade processes (classical and lectin complement activation; blood coagulation) together with endothelial barrier regulation and leukocyte migration, pointing to a coordinated vascular inflammatory/immune remodeling theme. Collagen catabolic activity suggests ECM remodeling, while some developmental terms may reflect shared regulatory modules or background annotations. Overall, the dominant pattern fits immune-coagulation and vascular integrity during inflammation, with developmental terms likely ancillary. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0030901","count":12},{"id":"GO:0006958","count":9},{"id":"GO:0007596","count":9},{"id":"GO:0060021","count":8}]},{"hash":"1764736145535998049","title":"Actin-regulated immune response and phagocytosis","description":"These proteins are enriched for immune-related functions (adaptive immune response, phagocytosis) and for actin cytoskeleton remodeling (barbed-end actin filament capping, actin cortical patch assembly). The combination suggests a core theme of actin-driven processes that enable immune cell functions like phagocytosis, with signaling terms (GTPase activity, tyrosine phosphorylation) supporting cytoskeletal changes. Some terms reference TGF-beta signaling and development, which can relate to immune regulation and tissue remodeling, but the dominant pattern is actin dynamics linked to immune activity. Overall, the cluster likely represents actin-mediated immune responses, especially phagocytosis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002250","count":5},{"id":"GO:0051016","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0050731","count":5},{"id":"GO:0006909","count":5}]},{"hash":"1675660878509320050","title":"GPCR-CAMP Cardiovascular Signaling","description":"This cluster is driven by GO terms centered on G protein-coupled receptor signaling that activates adenylate cyclase and cAMP (e.g., adenylate cyclase-activating GPCR signaling; activation of adenylate cyclase), with related cardiovascular processes such as positive regulation of blood pressure, muscle relaxation, and blood coagulation. While there are also terms like xenobiotic response and electron transport chain, the dominant pattern ties GPCR-cAMP signaling to cardiovascular regulatory functions.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0035025","count":7},{"id":"GO:0007190","count":5}]},{"hash":"1878975654926402131","title":"Dopamine Signaling Modulation","description":"The dominant GO terms center on regulation of dopaminergic signaling\u2014negative regulation of dopamine receptor signaling, GPCR- and cAMP-related pathways, and dopamine transport\u2014indicating the proteins likely act to dampen or tune dopamine signaling in neurons. A few outlier terms related to neural development or immune differentiation are present, but the core theme is dopaminergic signal regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":18},{"id":"GO:0090075","count":18},{"id":"GO:0007194","count":18},{"id":"GO:0016998","count":18},{"id":"GO:0040015","count":18}]},{"hash":"1081688655085037326","title":"Neural Sensory Perception and Cerebellar Differentiation","description":"Top GO terms indicate sensory detection of mechanical and heat stimuli and cerebellar granule cell differentiation, suggesting a neural sensing and development theme. Additional terms related to vesicle trafficking, transcription regulation, and PARylation support roles in neuronal signaling and cellular regulation, though some terms are more peripheral (e.g., endothelial proliferation). Overall, the cluster appears best described by neural sensory perception and development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":5},{"id":"GO:0035544","count":5},{"id":"GO:0050960","count":5},{"id":"GO:0021707","count":5},{"id":"GO:0016049","count":5}]},{"hash":"2132601316539853444","title":"Endothelial adhesion and angiogenesis regulation","description":"The prominent GO terms cluster around endothelial biology and vascular remodeling: negative regulation of angiogenesis, endothelial cell chemotaxis, endothelial cell-cell adhesion, and integrin-mediated cell-matrix adhesion, plus smooth muscle cell migration and heart/vascular development (ventricular septum development). These together point to a group of proteins involved in vascular development, endothelial adhesion, and regulation of angiogenesis, rather than a single isolated function. Unknown terms like gastrulation also fit into broad developmental contexts, reinforcing a vascular-development theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":6},{"id":"GO:2001027","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0071603","count":5},{"id":"GO:0001702","count":5}]},{"hash":"972479172421474249","title":"Embryonic organogenesis and tissue morphogenesis","description":"The top GO terms span multiple organ development processes (roof of mouth, uterus, pituitary gland, outflow tract morphogenesis, hindlimb morphogenesis, digestive tract, midbrain, inner ear, camera-type eye) and include negative regulation of transcription by RNA polymerase II, implying these proteins may function as transcriptional repressors during embryogenesis. The diversity of tissues suggests a general role in embryonic development and organ morphogenesis rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0060021","count":5},{"id":"GO:0060065","count":5},{"id":"GO:0021983","count":4},{"id":"GO:0003148","count":4}]},{"hash":"145071666983358574","title":"Endosome-Golgi trafficking and polarity","description":"This cluster centers on membrane trafficking and polarity-related processes: late endosome to Golgi transport, intralumenal vesicle formation, and regulation of microvillus assembly and cell polarity. Phosphatidic acid biosynthesis ties into membrane dynamics needed for vesicle formation and polarity maintenance. Some developmental GO terms (eye, cranial skeletal, adipose development) may reflect broader roles of these trafficking/polarity regulators in tissue development. Overall, the shared theme is vesicle trafficking coupled with cell polarity in cellular organization and development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006654","count":3},{"id":"GO:0032534","count":2},{"id":"GO:2000769","count":2},{"id":"GO:0048310","count":2},{"id":"GO:0034499","count":2}]},{"hash":"68407833955133788","title":"Embryonic mesodermal and craniofacial development","description":"The top GO terms cluster around embryonic development, particularly mesoderm derivatives and morphogenesis of structures like the heart (endocardial cushion formation), cartilage, and craniofacial regions (roof of mouth). While there are some transcriptional regulatory processes present, the dominant theme is early developmental morphogenesis affecting mesoderm and craniofacial/heart structures.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0007498","count":4},{"id":"GO:0060806","count":4}]},{"hash":"2053103795969650664","title":"Embryogenesis and morphogenesis","description":"Most of the top GO terms cluster around embryo development and tissue/organ formation\u2014placental development, mesoderm formation, palate/roof of mouth development, left-right patterning, and EMT in heart development\u2014indicating a coherent set of proteins involved in early developmental processes and organ morphogenesis.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060806","count":16},{"id":"GO:0035270","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060707","count":16},{"id":"GO:0060972","count":16}]},{"hash":"1195353786640655422","title":"Multi-lineage cell fate specification","description":"This cluster is enriched for diverse cell fate and differentiation terms across tissues (neural lineages, skeletal muscle, pancreas, melanocytes, bronchioles), suggesting proteins involved in broad lineage specification rather than a single tissue-specific process. The common thread is developmental differentiation programs spanning multiple lineages.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0031018","count":9},{"id":"GO:0021530","count":8},{"id":"GO:0021520","count":8},{"id":"GO:0021892","count":8}]},{"hash":"2196419520955722026","title":"Embryogenesis and Organogenesis","description":"Most of the top GO terms describe developmental processes across multiple organs (gonads, limbs, adrenal glands, heart, and glands) and embryo implantation. This suggests the cluster is centered on embryonic development and organogenesis, with a few ancillary terms (metabolism and immune signaling) that are less central to the core theme.","confidence":"High","size":17,"edges":9,"triangles":4,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045720","count":12},{"id":"GO:0008584","count":12},{"id":"GO:0007566","count":12},{"id":"GO:0060173","count":12},{"id":"GO:0030325","count":12}]},{"hash":"375885453357345960","title":"Neural development and synaptic signaling","description":"The top GO terms are dominated by nervous system-related processes: axonogenesis, Schwann cell development, long-term synaptic potentiation, excitatory postsynaptic potential, visual perception, and general multicellular organism development, all pointing to neural differentiation and synaptic maturation. Some terms like heart development and response to muscle activity are broader or ancillary, but the central theme is neural development and synaptic function.","confidence":"High","size":17,"edges":125,"triangles":539,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":13},{"id":"GO:0014850","count":12},{"id":"GO:0000086","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0007409","count":11}]},{"hash":"424999500715732233","title":"Mitochondrial Translation and Respiratory Assembly","description":"The cluster is dominated by mitochondrial-specific processes: mitochondrial translation, import into the mitochondrial matrix, ATP synthase complex assembly, and mitochondrial electron transport, pointing to a cohesive theme of mitochondrial protein synthesis and energy metabolism. A few non-mitochondrial terms appear but are minor on the list, so the core function is mitochondrial gene expression and respiration.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0033615","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0035551","count":1}]},{"hash":"31413772328757695","title":"Ribosome biogenesis and translation with transcription control","description":"Proteins in this cluster are enriched for ribosome biogenesis, large subunit export from the nucleus, and translation, with accompanying transcription-related terms (initiation, termination, antitermination) and protein targeting, suggesting a coordinated program linking transcription regulation to ribosome assembly and protein synthesis, possibly with cell-cycle coupling reflected by mitotic chromosome alignment.","confidence":"Medium","size":17,"edges":127,"triangles":559,"max_degree":16,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0006367","count":4},{"id":"GO:0000055","count":4},{"id":"GO:0006412","count":3},{"id":"GO:1990145","count":3}]},{"hash":"530515261303994860","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000462","count":17},{"id":"GO:0042273","count":17},{"id":"GO:0000466","count":17},{"id":"GO:0000398","count":17},{"id":"GO:0000463","count":17}]},{"hash":"1179009511294097370","title":"Post-transcriptional mRNA regulation","description":"This cluster is dominated by GO terms tied to mRNA fate after transcription: stability, splicing and splice site recognition, mRNA modification, and translation initiation complex assembly. The inclusion of regulatory ncRNA-mediated gene silencing and stress-related mRNA stability suggests a cohesive role in post-transcriptional control of gene expression through RNA processing and stability mechanisms.","confidence":"High","size":17,"edges":61,"triangles":80,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":16},{"id":"GO:0031047","count":16},{"id":"GO:1905663","count":15},{"id":"GO:0097010","count":15},{"id":"GO:0016556","count":15}]},{"hash":"166381575094681546","title":"RNA processing and translation initiation","description":"This cluster shows strong representation of GO terms tied to translation initiation and mRNA processing, including formation of the translation preinitiation complex, eIF4F complex assembly, translation reinitiation, mRNA splicing/splice site recognition, and mRNA stabilization/modification. The combination points to a cohesive role in post-transcriptional gene regulation, coordinating RNA processing with the initiation of translation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":10},{"id":"GO:0002188","count":10},{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:1905663","count":6}]},{"hash":"835305887136981262","title":"Embryonic organogenesis and morphogenesis","description":"This cluster's top GO terms span lung and heart development, neural plate morphogenesis, notochord formation, mesodermal transitions, and patterning events, indicating a broad program of tissue formation during embryogenesis rather than a single pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0003151","count":1},{"id":"GO:0035050","count":1},{"id":"GO:0001839","count":1}]},{"hash":"1437186080138918590","title":"Flavonoid and Phenolic Biosynthesis","description":"This cluster shows multiple terms tied to biosynthesis and modification of flavonoids and phenolic compounds (anthocyanin-containing, kaempferol glucoside, and related pathways), as well as related xenobiotic modification. While there are some broader or non-phenolic terms present (e.g., lipoteichoic acid biosynthesis, cell cycle), the strongest signal centers on flavonoid/phenolic metabolism, suggesting the proteins participate in phenolic compound production or remodeling. Confidence: Medium","confidence":"","size":17,"edges":72,"triangles":120,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0070980","count":4},{"id":"GO:0008360","count":4},{"id":"GO:0009718","count":4},{"id":"GO:0071412","count":4}]},{"hash":"962997489786881351","title":"Prostaglandin signaling and MAPK regulation","description":"This cluster centers on prostaglandin biosynthesis and negative regulation of key MAPK pathways (ERK1/2 and JNK), plus related inflammatory and stress-response terms such as response to toxic substances and MCP-1 production. The combination suggests a cohesive theme around prostaglandin-driven signaling that modulates inflammatory signaling networks and cell survival, with some signals pointing to regeneration and metabolic or progenitor-cell context. Overall, the label reflects the core function of prostaglandin-mediated signaling intertwined with MAPK pathway regulation.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":16},{"id":"GO:2001237","count":16},{"id":"GO:0043508","count":16},{"id":"GO:0031100","count":16},{"id":"GO:0070373","count":16}]},{"hash":"1480801843519079152","title":"Oxidative Stress Response and Redox Homeostasis","description":"The top GO terms cluster around detoxification of oxidants, cellular redox balance, and the cellular response to oxidative stress, indicating a core function in managing reactive oxygen species. While some terms touch on ion stress or developmental processes, the oxidative stress/redox theme is dominant and representative of the cluster.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":12},{"id":"GO:0043535","count":9},{"id":"GO:0045454","count":9},{"id":"GO:0034599","count":6},{"id":"GO:2000651","count":6}]},{"hash":"1506486268701206774","title":"Developmental signaling and ECM remodeling","description":"The terms point to growth-factor\u2013driven development (BMP response, VEGF signaling, HGF pathway modulation) and extracellular matrix dynamics (collagen biosynthesis, proteoglycan turnover), with reproductive processes (ovulation, fertilization) and cartilage-related differentiation being prominent as well. Together, these suggest a cohesive theme of development-associated signaling intertwined with ECM remodeling, with a minor immune-regulatory signal elsewhere. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0032331","count":7},{"id":"GO:1900748","count":7},{"id":"GO:0007338","count":7},{"id":"GO:0045959","count":7},{"id":"GO:0001542","count":7}]},{"hash":"1244691184416547357","title":"Growth Signaling and Ubiquitin Regulation","description":"The top GO terms cluster around regulation of cell growth, growth hormone receptor signaling, and negative regulation of apoptosis, paired with protein ubiquitination and proteasomal degradation. This points to a core theme of coordinating cell growth and survival through ubiquitin-dependent protein turnover and signaling pathways. Additional terms touch on vascular/mechanical signaling and small GTPase\u2013mediated signaling, which are commonly involved in growth/survival responses, reinforcing the overall theme of growth-regulatory signaling with regulated protein turnover.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042518","count":7},{"id":"GO:0001558","count":7},{"id":"GO:0060396","count":7},{"id":"GO:0043066","count":6},{"id":"GO:0016567","count":6}]},{"hash":"1886867524684508139","title":"Immune Activation Signaling","description":"Cluster enriched for immune-related GO terms: T cell receptor signaling, GM-CSF response, LPS response, innate immune response, and defense against Gram-positive bacteria, together with DNA-templated transcription and major signaling pathways. This points to a common theme of immune activation and inflammatory signaling, with forebrain development and Hippo/Wnt terms likely representing pleiotropic or secondary associations. ","confidence":"High","size":17,"edges":26,"triangles":17,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":12},{"id":"GO:0097011","count":12},{"id":"GO:0071222","count":12},{"id":"GO:0006351","count":12},{"id":"GO:0045087","count":11}]},{"hash":"636280949695129042","title":"Neural development and cell adhesion proteins","description":"The cluster is dominated by GO terms on nervous system development and synapse assembly, with multiple entries for homophilic and calcium-dependent cell-cell adhesion, suggesting a set of adhesion molecules that guide neural connectivity and broader tissue morphogenesis (including bone, ureter, and vasculature development). This combination points to a cohesive theme around neural development and adhesion-mediated morphogenesis, though the terms span several tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007399","count":3}]},{"hash":"990629122975706596","title":"Neural development and forebrain patterning","description":"The Top Terms cluster strongly around neural development: neuron migration, neuron differentiation, forebrain development, and cerebral cortex regionalization, plus medial motor column neuron differentiation. A few terms touch broader embryonic patterning (heart, pancreas, vitamin A metabolism), but the dominant signal is neurodevelopment and brain regionalization, justifying this label. ","confidence":"High","size":17,"edges":26,"triangles":0,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001764","count":17},{"id":"GO:0061452","count":17},{"id":"GO:0030900","count":17},{"id":"GO:0060971","count":17},{"id":"GO:0003309","count":17}]},{"hash":"1544885565176617269","title":"Glycolysis and TCA cycle core metabolism","description":"The top GO terms cluster around central carbon metabolism: glycolytic process, tricarboxylic acid cycle, 2-oxoglutarate and isocitrate metabolism, and NADPH regeneration, indicating a core energy-metabolism group. A few minority terms relate to amino acid biosynthesis or regulation, but the dominant signal is glycolysis/TCA activity.","confidence":"High","size":17,"edges":126,"triangles":548,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":9},{"id":"GO:0019878","count":8},{"id":"GO:0006103","count":7},{"id":"GO:0006096","count":5},{"id":"GO:0033512","count":5}]},{"hash":"1327289056453309038","title":"Ubiquitin-Proteasome Regulation of NF-kappaB","description":"This cluster is dominated by GO terms tied to ubiquitin-dependent protein degradation (proteasomal and ERAD pathways), various ubiquitination events, and regulation of NF-kappaB signaling and apoptosis, as well as TNF signaling. The presence of histone ubiquitination and autoubiquitination terms expands to chromatin turnover and self-ubiquitination, all pointing to coordinated protein turnover and signaling control via ubiquitination.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:1903265","count":12},{"id":"GO:0036205","count":12},{"id":"GO:0085020","count":12},{"id":"GO:0030433","count":12}]},{"hash":"546987667210034172","title":"Vesicle trafficking and cytoskeleton dynamics","description":"The top GO terms cluster around membrane trafficking and cytoskeleton-driven transport, including endosome-to-lysosome transport, Golgi-to-ER retrograde transport, microtubule-based movement, and calcium-regulated exocytosis (acrosome reaction). The presence of glucose transporter activity also fits membrane transport themes. While a few terms touch on development or signaling regulation (Rho/Ras), the dominant signal is vesicle trafficking and cytoskeleton dynamics. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0015758","count":3},{"id":"GO:0045956","count":3},{"id":"GO:0007018","count":3},{"id":"GO:0007340","count":3},{"id":"GO:0060313","count":3}]},{"hash":"1351796774673412228","title":"Mitochondrial Metabolism and RNA Modification","description":"The cluster is enriched for mitochondrial energy-related terms (NADH to ubiquinone electron transport and complex II assembly) along with RNA and protein modification/processing terms (RNA guanine-N7 methylation, N-terminal peptidyl-alanine trimethylation) and translation. This combination suggests a core link to mitochondrial function and gene expression modulation, with some additional lipid/bio-synthesis signals that reflect broader metabolic activity.","confidence":"Medium","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0006656","count":3},{"id":"GO:0034553","count":2},{"id":"GO:0051591","count":2}]},{"hash":"565805514276543038","title":"Ubiquitin-mediated protein turnover and apoptosis control","description":"The cluster shows strong enrichment for ubiquitination processes (protein ubiquitination, polyubiquitination, autoubiquitination) and negative regulation of apoptosis and necroptosis, plus regulation of Toll-like receptor signaling, indicating a cohesive role in marking proteins for degradation and in modulating cell death and immune signaling. The presence of a vitamin D response term may reflect broader immune-metabolic regulation linked to ubiquitin pathways.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043066","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0042787","count":6},{"id":"GO:0051865","count":6},{"id":"GO:0033280","count":6}]},{"hash":"957182439037283333","title":"Ubiquitin-proteasome pathway and immune signaling","description":"The cluster strongly centers on ubiquitination and proteasome processes (protein ubiquitination; ubiquitin-dependent protein catabolic process; proteasome regulatory particle assembly) with an adaptive immune response term, suggesting a cohesive role in ubiquitin-mediated protein turnover linked to immune signaling, despite some ancillary terms.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":9},{"id":"GO:0071260","count":7},{"id":"GO:0033280","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0007205","count":6}]},{"hash":"1079341341450394266","title":"Neural-immune signaling","description":"The terms show a mix of neural functions (nerve impulse transmission, paranodal junction assembly, cardiac conduction) and immune regulation (cytokine production, NK cell activity, macrophage regulation, peptidoglycan response), suggesting a theme of neural signaling modulated by immune processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":6},{"id":"GO:2001046","count":4},{"id":"GO:0030913","count":4},{"id":"GO:0086091","count":4},{"id":"GO:0002860","count":4}]},{"hash":"1563358707968095995","title":"Dopamine GPCR\u2013cAMP Regulators","description":"The top GO terms cluster around dopaminergic signaling and regulation of cAMP production (negative regulation of dopamine receptor signaling, negative regulation of adenylate cyclase activity, adenylate cyclase-inhibiting GPCR signaling, dopamine transport), suggesting proteins that modulate GPCR signaling in the dopamine pathway. While a few terms refer to unrelated processes (muscle relaxation, cell wall catabolism, thymocyte differentiation, cortex neuron migration), the dominant theme is neural GPCR signaling and cAMP control, making a dopaminergic GPCR/cAMP regulator interpretation plausible though not exclusive.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":16},{"id":"GO:0090075","count":16},{"id":"GO:0007194","count":16},{"id":"GO:0016998","count":16},{"id":"GO:0040015","count":16}]},{"hash":"1144095007804152957","title":"Neurotransmitter GPCR Signaling Regulation","description":"This cluster is dominated by GO terms about regulating GPCR signaling and downstream pathways (ERK cascade, adenylate cyclase activity, dopamine and acetylcholine receptor signaling, and dopamine transport), indicating proteins that modulate neurotransmitter receptor signaling and related kinase activity. A few terms (defense response to bacterium, cell wall catabolic process) are less connected and may reflect broader annotations, but the core pattern supports GPCR-mediated signaling regulation in neural/muscular contexts.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":15},{"id":"GO:0042742","count":15},{"id":"GO:0060160","count":14},{"id":"GO:0090075","count":14},{"id":"GO:0007194","count":14}]},{"hash":"723086670528415607","title":"Nuclear Transport and Chromatin/Mitosis Regulation","description":"This cluster is enriched for nuclear processes: NLS-bearing protein import, chromatin assembly during DNA replication, chromatid cohesion in meiosis, and mitotic nuclear membrane reassembly. Additional terms point to transcription by RNA Pol III and mRNA transport, i.e., nuclear gene expression and RNA trafficking. Together these suggest a theme of nuclear transport, chromatin maintenance, and cell-cycle\u2013related regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006335","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0051754","count":2},{"id":"GO:0033674","count":2}]},{"hash":"654274198008678489","title":"Chromatin regulation during mitosis and neural development","description":"This cluster centers on epigenetic control (histone methylation) and cell division (mitotic cell cycle, APC-dependent catabolic process), with additional signals related to neural development such as neuron projection and forebrain development, suggesting a theme of chromatin dynamics coupled to developmental processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2001162","count":5},{"id":"GO:0071276","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0031145","count":5},{"id":"GO:0031175","count":5}]},{"hash":"1917589457510113857","title":"Dopaminergic signaling and neuronal development","description":"The top GO terms cluster around dopamine signaling regulation (negative regulation of dopamine receptor signaling, dopamine transport) and related GPCR signaling pathways, along with cortical interneuron migration, pointing to a neural signaling and development theme. Some terms (like thymocyte differentiation) appear discordant but do not override the dominant dopaminergic/neural signal pattern.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":16},{"id":"GO:0090075","count":16},{"id":"GO:0007194","count":16},{"id":"GO:0016998","count":16},{"id":"GO:0040015","count":16}]},{"hash":"644147680340433180","title":"Vertebrate development and chromatin regulation","description":"The top GO terms emphasize vertebrate developmental processes (spinal cord, heart, sensory perception, multicellular development) alongside signaling pathways (Rho signaling, GPCR-PLC signaling), cytoskeletal movement, and chromatin regulation (chromatin organization, histone acetylation). This suggests a cluster of proteins that coordinate developmental signaling with transcriptional regulation and cytoskeletal dynamics.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0061000","count":2}]},{"hash":"2137377374786542983","title":"Developmental morphogenesis and RNA-based regulation","description":"This cluster is driven by GO terms for developmental processes (neural crest migration, odontogenesis, ureteric bud branching) together with regulatory ncRNA\u2013mediated gene silencing, indicating roles in developmental regulation and transcriptional/post-transcriptional control; several non-informative obsolete terms are likely noise.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904753","count":2},{"id":"GO:1904706","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0001755","count":2},{"id":"GO:0042475","count":2}]},{"hash":"1894866396442293936","title":"Autophagy and vacuolar targeting machinery","description":"This cluster is dominated by GO terms tied to autophagy processes (autophagosome assembly, piecemeal microautophagy of the nucleus, Cvt pathway, and protein targeting to vacuole involved in autophagy) and general vesicle trafficking from ER to Golgi, indicating a focused role in autophagy and vacuolar degradation pathways. The additional stress-response terms (to hydrogen peroxide and metal ions) likely reflect cellular conditions that modulate autophagic activity, but the core signal is autophagy/vacuolar targeting.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000045","count":7},{"id":"GO:0034727","count":7},{"id":"GO:0030433","count":6},{"id":"GO:0006888","count":4},{"id":"GO:0010040","count":4}]},{"hash":"327112245872150730","title":"Autophagy and ubiquitin-like modification","description":"This cluster is driven by GO terms related to autophagy (e.g., autophagy of mitochondrion, piecemeal microautophagy of the nucleus, Cvt pathway) and by ubiquitin-like protein modifications (sumoylation, ufmylation). The convergence on autophagy-related processes and regulation by ubiquitin-like modifiers suggests a coherent theme of selective protein turnover and lysosome/vacuole targeting. Some terms such as amygdala development and thiamine biosynthesis are outliers or broader annotations, but the dominant signal is autophagy and related protein modification.","confidence":"High","size":16,"edges":98,"triangles":315,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":6},{"id":"GO:0034727","count":6},{"id":"GO:0045892","count":4},{"id":"GO:0051726","count":4},{"id":"GO:0018192","count":4}]},{"hash":"2134268742060787045","title":"Nuclear transcription and deubiquitination","description":"This cluster centers on DNA-templated transcription and mRNA processing, with strong representation of deubiquitination activities across multiple ubiquitin linkages (K29, K48, K11, K6) and ubiquitin-dependent protein catabolic processes. The co-occurrence of transcription/RNA processing terms with ubiquitin signaling suggests a cohesive theme of nuclear gene expression regulation modulated by ubiquitin-mediated proteostasis. While some terms touch on broader proteostasis (ERAD-related), the core pattern points to transcriptional control tied to deubiquitination. Confidence: High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000352","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0006511","count":3}]},{"hash":"1254866256132535618","title":"HDAC-Mediated Transcriptional Repression","description":"The cluster\u2019s terms cluster around epigenetic control of gene expression: deacetylation of lysine residues, DNA methylation\u2013dependent heterochromatin formation, and heterochromatin maintenance, all pointing to histone deacetylases driving transcriptional silencing; some terms reflect downstream effects on pathways like androgen signaling and muscle differentiation, which can be modulated by chromatin state.","confidence":"High","size":16,"edges":97,"triangles":292,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":16},{"id":"GO:0045668","count":16},{"id":"GO:0043433","count":10},{"id":"GO:0034983","count":10},{"id":"GO:0006344","count":10}]},{"hash":"736675694243943073","title":"Diverse Metabolite Biosynthesis","description":"Top GO terms point to biosynthesis of a variety of metabolites, including retinoids (retinol/retinal), steroids (testosterone), lipids (sphinganine, mycolic acids), and other small molecules (PHB, tropane alkaloids). This broad collection suggests the cluster is tied to diverse biosynthetic processes rather than a single pathway, with some noise from obsolete terms and unrelated processes. Thus, the label reflects a general theme of metabolite biosynthesis across multiple pathways.","confidence":"Medium","size":16,"edges":5,"triangles":1,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0042574","count":9},{"id":"GO:0042572","count":9},{"id":"GO:0061370","count":8},{"id":"GO:0031427","count":7}]},{"hash":"1889172844794292464","title":"Neuronal Synaptic Signaling","description":"The top GO terms cluster around synaptic processes\u2014acetylcholine turnover in the synaptic cleft, regulation of synaptic vesicle exocytosis, inhibitory synapse assembly, and retrograde trans-synaptic signaling\u2014pointing to neuronal communication at synapses. Some terms (retina development, plant hormone signaling) appear broader or cross-species, but the dominant theme is synaptic transmission.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060041","count":8},{"id":"GO:0002076","count":8},{"id":"GO:0002087","count":8},{"id":"GO:0001507","count":7},{"id":"GO:0098942","count":7}]},{"hash":"61512994836146770","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":106,"triangles":400,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051259","count":6},{"id":"GO:0006626","count":6},{"id":"GO:0006458","count":6},{"id":"GO:0009408","count":6},{"id":"GO:1900035","count":6}]},{"hash":"401807285577630221","title":"Insulin and IGF Signaling in Metabolism","description":"The top GO terms cluster around insulin receptor signaling, IGF receptor signaling, regulation of glycogen biosynthesis, and fatty acid metabolism, suggesting a coherent role in hormonal control of energy metabolism. Additional terms related to vasoconstriction and cardiac muscle contraction align with metabolic regulation impacting cardiovascular function. Overall, this cluster appears driven by insulin/IGF signaling modulating glucose and lipid pathways and related physiology.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0045907","count":8},{"id":"GO:0045725","count":7},{"id":"GO:0032000","count":7},{"id":"GO:0048009","count":7},{"id":"GO:0010748","count":7}]},{"hash":"60589675710695598","title":"Axon Guidance and Neuron Migration","description":"This cluster is dominated by GO terms related to axon guidance and neuronal projection development, including sympathetic neuron projection guidance, neural crest migration, semaphorin-plexin signaling in axon guidance, and trigeminal/branchiomotor neuron axon guidance. A minority of terms reference immune processes and cell adhesion, which may reflect broader cellular interactions but do not detract from the central neural wiring theme. Thus, the label captures the primary function of the cluster.","confidence":"High","size":16,"edges":5,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0097491","count":8},{"id":"GO:0036486","count":8},{"id":"GO:1902287","count":8},{"id":"GO:0021637","count":8},{"id":"GO:0021785","count":8}]},{"hash":"211677515307297789","title":"Leukocyte adhesion and cytokine signaling","description":"The top GO terms point to cell-cell adhesion among leukocytes (heterophilic and homophilic) and a broader set of immune-regulatory processes, including T cell proliferation, NK cell activity, IL-4 production, cytokine production, and responses to peptidoglycan, suggesting a cohesive theme of leukocyte interactions and immune signaling; the presence of a host-symbiont entry term may reflect immune monitoring at host\u2013microbe interfaces.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":11},{"id":"GO:0007156","count":10},{"id":"GO:0046718","count":9},{"id":"GO:0042102","count":9},{"id":"GO:0086091","count":8}]},{"hash":"771558420468826327","title":"Cartilage development and skeletal ECM organization","description":"This cluster features GO terms tied to cartilage formation and skeletal development (skeletal system development, cartilage condensation, chondrocyte development) and to structural collagen fibril organization, suggesting a role in cartilage ECM assembly. While a few terms relate to CNS development and innate immunity, the dominant signal points to skeletal/cartilage biology.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0001502","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0051965","count":4}]},{"hash":"995115042565921279","title":"Ribosome biogenesis and translation","description":"The dominant GO terms are translation and ribosomal subunit assembly/biogenesis, indicating this cluster mainly comprises proteins involved in ribosome production and protein synthesis. Other terms (DNA repair, mitotic checkpoints) appear less frequently and may reflect additional roles, while a retinal ganglion cell axon guidance term seems to be an outlier. Overall, the cluster centers on ribosome-related machinery.","confidence":"High","size":16,"edges":111,"triangles":451,"max_degree":15,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0006281","count":4},{"id":"GO:0071549","count":4},{"id":"GO:0000027","count":4},{"id":"GO:0000028","count":3}]},{"hash":"2068396335017504729","title":"RNA Processing and Transcription Elongation","description":"The cluster centers on RNA processing and transcription regulation: mRNA capping, export, and polyadenylation, plus transcription elongation by RNA polymerase II and its positive regulation. These terms together suggest a group of proteins involved in RNA maturation and control of transcriptional elongation. The metencephalon development term is less aligned with the RNA-centric theme and may reflect broader annotation rather than a core cluster function. Confidence: High","confidence":"","size":16,"edges":26,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":3},{"id":"GO:0022037","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0006378","count":2},{"id":"GO:0098789","count":2}]},{"hash":"657995902136014794","title":"Ribosome Biogenesis and rRNA Maturation","description":"The cluster is dominated by GO terms for ribosome biogenesis and rRNA maturation (e.g., maturation of SSU/LSU rRNA and large subunit biogenesis), suggesting a core function in ribosome assembly and RNA processing. Other terms like mRNA splicing also reflect RNA processing themes, but the strongest signal is ribosome-related, justifying the label.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042273","count":6},{"id":"GO:0048701","count":6},{"id":"GO:0009432","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0000462","count":5}]},{"hash":"897969655912317806","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":9},{"id":"GO:0019878","count":4},{"id":"GO:0042594","count":4},{"id":"GO:0007584","count":4},{"id":"GO:0006096","count":4}]},{"hash":"41851724576869074","title":"Oxidative stress detoxification and DNA repair","description":"This cluster is enriched for redox and detoxification processes (cellular oxidant detoxification, redox homeostasis, response to toxic substances, toxin catabolic process) along with nucleotide-excision repair, suggesting a group of proteins focused on mitigating oxidative damage and preserving genome integrity under stress. Some terms also hint at broader metabolic and calcium signaling roles, indicating a coordinated stress-response module.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":11},{"id":"GO:0045454","count":7},{"id":"GO:0009636","count":6},{"id":"GO:0009072","count":6},{"id":"GO:0009407","count":6}]},{"hash":"9281508366830967","title":"Neuronal development and axon guidance signaling","description":"The top GO terms cluster around nervous system development, ephrin receptor signaling, and axon growth (positive regulation of axon extension, negative regulation of axonogenesis), with supportive signals in calcium-dependent exocytosis and ERK cascade, indicating a theme of neuronal signaling and axon guidance rather than unrelated processes.","confidence":"High","size":16,"edges":26,"triangles":15,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045956","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0048013","count":12},{"id":"GO:0033138","count":12}]},{"hash":"889003493746101827","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034502","count":2},{"id":"GO:0070476","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0071039","count":1},{"id":"GO:0034476","count":1}]},{"hash":"450177707339584196","title":"Cerebral Cortex Development and Cocaine-Responsive Signaling","description":"The top GO terms point to cortical development and neural maturation (layer formation in the cortex, visual perception/learning, synapse assembly) along with signaling pathways (ERK cascade) and behavioral responses to cocaine. The presence of angiogenesis and chondrocyte differentiation suggests broader developmental signaling, but the core theme appears to be cortex development and neural plasticity with cocaine-associated modulation.","confidence":"Medium","size":16,"edges":11,"triangles":7,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051965","count":11},{"id":"GO:0007601","count":10},{"id":"GO:0021819","count":10},{"id":"GO:0042220","count":10},{"id":"GO:0019233","count":10}]},{"hash":"64604618920084874","title":"Dopaminergic Signaling and Cocaine Response","description":"The proteins cluster around nervous system signaling, with strong GO terms for dopaminergic synaptic transmission, cocaine-related behavioral responses, visual perception/learning, and ERK cascade regulation downstream of neural activity, suggesting a coherent theme of dopamine-driven neural signaling and drug-related responses. Though terms like heart development and antibacterial defense appear among annotations, they likely reflect pleiotropy or broad functional annotations rather than a different module.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0048148","count":13},{"id":"GO:0010759","count":13}]},{"hash":"1398977925953970058","title":"Central metabolism and cell wall processes","description":"The top GO terms cluster around core metabolic pathways (gluconeogenesis, glycolysis, various catabolic routes such as amino acids, mandelate, and D-galactonate) and a menaquinone biosynthetic process, together with cell wall organization/catabolic processes. This suggests a group of proteins involved in energy metabolism and cell wall remodeling. Some terms like skeletal muscle tissue regeneration and hypoxia-induced apoptotic signaling appear as outliers, but the dominant theme is metabolism linked to cell envelope dynamics.","confidence":"Medium","size":16,"edges":16,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":7},{"id":"GO:0006094","count":5},{"id":"GO:1903298","count":5},{"id":"GO:0034194","count":5},{"id":"GO:0016998","count":5}]},{"hash":"75838485390424525","title":"Axon Guidance and Neuronal Adhesion","description":"The cluster\u2019s top GO terms center on axon pathfinding, neuron projection guidance, and neural cell-cell adhesion (axonal fasciculation, sympathetic neuron projection guidance, trigeminal nerve organization, neural crest migration, and semaphorin-plexin signaling), indicating proteins involved in guiding growing axons and coordinating neural cell adhesion during development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":10},{"id":"GO:0051965","count":9},{"id":"GO:0007157","count":8},{"id":"GO:0014068","count":8},{"id":"GO:0007156","count":8}]},{"hash":"1395079990760576932","title":"Retina photoreceptor GPCR signaling","description":"These proteins appear to form a photoreceptor/retinal signaling module: strong enrichment for visual perception, opsin-mediated signaling, GPCR internalization, and downstream signaling (ERK cascade, GTPase activity) together with dopaminergic synaptic transmission and visual learning. This points to coordinated GPCR trafficking and signaling in visual processing rather than a general developmental program, despite one term related to heart development; the visual system theme dominates. ","confidence":"High","size":16,"edges":63,"triangles":84,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002031","count":13},{"id":"GO:0071380","count":13},{"id":"GO:0007507","count":13},{"id":"GO:0022400","count":13},{"id":"GO:0019233","count":13}]},{"hash":"2010203462328318475","title":"Bacterial lipid and cell envelope biosynthesis","description":"The cluster centers on fatty acid biosynthesis and metabolism (long/medium-chain acyl-CoA), long-chain fatty acid import, and lipoteichoic acid biosynthesis, with additional links to menaquinone biosynthesis and related CoA pathways. Collectively, these terms reflect bacterial membrane lipid production and cell envelope assembly, particularly in Gram-positive organisms. A few outlier terms (bioluminescence, seed germination) may be annotation noise.","confidence":"Medium","size":16,"edges":105,"triangles":382,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0070395","count":7},{"id":"GO:0036112","count":7},{"id":"GO:0010124","count":6},{"id":"GO:0044539","count":6},{"id":"GO:0008218","count":6}]},{"hash":"891824166832863065","title":"Steroid, Lipid, and Retinoid Biosynthesis","description":"The cluster centers on biosynthetic processes spanning lipids and lipid-derived mediators (fatty acid biosynthesis, prostaglandin biosynthesis), retinoids (retinol/retinal metabolic processes), and steroid hormones (testosterone and androgen biosynthesis), with additional signaling involvement (PI3K/AKT). While there is a secondary signal related to lipopolysaccharide response, the dominant pattern is coordinated metabolism of lipids, retinoids, and steroid hormones, suggesting a cohesive functional theme around lipid- and hormone-related biosynthesis. ","confidence":"High","size":16,"edges":114,"triangles":483,"max_degree":15,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0042572","count":7},{"id":"GO:0046370","count":6},{"id":"GO:0006633","count":6},{"id":"GO:0032496","count":4}]},{"hash":"749569896330831041","title":"Immune and neural signaling regulators","description":"This cluster shows strong representation of both immune and neural development terms (T cell receptor signaling and cerebellar cortex/Bergmann glia differentiation), along with broader signaling and cell-cycle regulation terms (insulin signaling, ERK cascade, CDK activity). The mix suggests proteins that modulate various signaling pathways affecting immune responses and neural development, rather than a single, cohesive pathway. Confidence: Medium","confidence":"","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050852","count":13},{"id":"GO:0021697","count":13},{"id":"GO:0048679","count":13},{"id":"GO:2001275","count":13},{"id":"GO:0060020","count":13}]},{"hash":"294315363719068","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060487","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0035753","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0008033","count":2}]},{"hash":"470074894020929006","title":"DNA Repair and Cell Cycle Regulation","description":"The top GO terms point to genome maintenance activities (base-excision repair, DNA replication, DNA recombination) and control of the G1/S transition in the cell cycle, indicating proteins involved in repairing DNA and coordinating replication with cell-cycle progression. Some inflammatory or xenobiotic-response terms may reflect broader roles, but the core theme is genome maintenance and cell-cycle control.","confidence":"High","size":16,"edges":82,"triangles":206,"max_degree":15,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0007568","count":6},{"id":"GO:0006284","count":6},{"id":"GO:0007420","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0042493","count":4}]},{"hash":"899128439193477414","title":"B cell antibody diversification and DNA repair","description":"The cluster centers on immunoglobulin gene diversification (somatic hypermutation and V-D-J recombination) and core DNA repair pathways (base-excision repair and nonhomologous end joining), with associated DNA damage responses, indicating a cohesive function in antibody gene remodeling tied to DNA repair.","confidence":"High","size":16,"edges":59,"triangles":91,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016446","count":5},{"id":"GO:0016579","count":5},{"id":"GO:0006286","count":5},{"id":"GO:0006284","count":5},{"id":"GO:0010332","count":5}]},{"hash":"1288141225562837461","title":"TNF-Driven Inflammation and Leukocyte Migration","description":"The top GO terms center on inflammatory signaling and immune cell movement, including responses to TNF, cellular response to TNF, leukocyte migration, and neutrophil extravasation, which point to inflammation-driven recruitment of immune cells. While terms like keratinocyte differentiation and Notch processing are present, the dominant theme remains inflammatory signaling and leukocyte trafficking, with integrin-mediated adhesion supporting cell migration. Overall, the cluster appears best described by an inflammatory and immune-cell\u2013recruitment theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0030216","count":5},{"id":"GO:0010042","count":5},{"id":"GO:0007220","count":5},{"id":"GO:0034612","count":5}]},{"hash":"551021702053275840","title":"Embryonic organogenesis and growth signaling","description":"These terms cluster around development and organ formation, including neural tube closure, angiogenesis, multicellular growth, lung differentiation, and cardiac-related processes, with transcriptional regulation and signaling (e.g., insulin signaling) providing regulatory control. The mix points to a cohesive theme of embryonic organogenesis and growth signaling rather than a single isolated pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001843","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0006349","count":3}]},{"hash":"851510408320993633","title":"Cortical Neuron Development and Synaptic Regulation","description":"This cluster centers on cortical neuron development and synaptic function, highlighted by terms for neuron migration, layer formation in the cerebral cortex, and neuron projection development, along with synaptic regulation topics such as exocytosis and receptor signaling. A secondary theme is intrinsic apoptotic signaling linked to ER stress, suggesting stress-responsive regulation of neuronal viability within this development/synaptic context.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0070059","count":2},{"id":"GO:0045956","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0031175","count":2}]},{"hash":"2130597281469113409","title":"Unknown","description":"The top GO terms span plant-specific catabolic processes (cellulose and chlorophyll degradation) and diverse animal processes (cell adhesion, endothelial migration, T cell costimulation, insulin secretion regulation, behavioral responses, and ECM remodeling) with no clear shared pathway or function, and there are no edges connecting the proteins, so there is no cohesive theme to name.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030245","count":4},{"id":"GO:0043542","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0015996","count":3},{"id":"GO:0031295","count":3}]},{"hash":"1726797624703121338","title":"Endocytic trafficking and apoptotic cell clearance","description":"The top GO terms emphasize endocytosis, endosome-to-lysosome transport, and engulfment of apoptotic cells, pointing to endosomal/lysosomal trafficking and phagocytic clearance as the core theme. Immune-related terms (defense response to protozoan) support a phagocytic context, while other terms (Wnt signaling, transcription) appear less central or incidental. Overall, the cluster likely reflects endocytic/phagocytic pathways rather than a single static process.","confidence":"High","size":16,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0060070","count":2},{"id":"GO:0033197","count":2},{"id":"GO:0006897","count":2}]},{"hash":"1121052622426175522","title":"Rac-driven actin remodeling and cell migration","description":"The proteins cluster around actin cytoskeleton dynamics (branching, bundle assembly, stress fibers), Rac signaling, cell adhesion/spreading, and polarity, with supporting roles in endocytosis and ephrin signaling. This pattern points to a cohesive function in actin-driven remodeling and migratory/aerotactic signaling rather than a single developmental endpoint, making \"Rac-driven actin remodeling and cell migration\" an appropriate label.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006897","count":5},{"id":"GO:0051496","count":5},{"id":"GO:1900026","count":5},{"id":"GO:0090135","count":4},{"id":"GO:0071803","count":4}]},{"hash":"259040004769493305","title":"Signaling and Cell Migration Cluster","description":"The terms cluster around regulation and activation of signaling pathways (Rho, PI3K/AKT, GPCR) and processes tied to cell movement and communication (cell migration, vesicle priming, acrosome reaction, development). This suggests the proteins function together in signaling cascades that control motility and cellular interactions across systems, rather than a single, specific pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0043491","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0007340","count":3},{"id":"GO:0016477","count":3}]},{"hash":"1082577143788160506","title":"Golgi-ER vesicle trafficking and endocytosis","description":"The top GO terms cluster around intracellular transport and vesicle dynamics involving the ER and Golgi (ER-to-Golgi transport, Golgi inheritance, endosome-to-Golgi retrograde transport, anterograde synaptic vesicle transport, and endocytosis) as well as vacuole targeting. This points to a coherent theme of vesicle trafficking and Golgi/ER maintenance, with a few peripheral terms (virus/xenobiotic response, locomotion) that are less central to the core function. ","confidence":"Medium","size":16,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009615","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0008344","count":3},{"id":"GO:0006623","count":3},{"id":"GO:0048490","count":3}]},{"hash":"2043105750003480901","title":"Rho and MAPK signaling in mechanotransduction","description":"This cluster\u2019s top GO terms cluster around signaling cascades, especially MAPK pathways (ERK1/ERK2 cascade and p38MAPK cascade) and Rho protein signaling, alongside responses related to mechanical stimuli (response to muscle stretch) and synaptic localization. Although there are also general terms like DNA replication/transcription, the strongest, more specific signals point to a signaling module that translates mechanical or cytokine cues into MAPK-driven signaling and downstream transcriptional responses, with potential links to synaptic dynamics. This justifies a label centered on mechanotransduction via Rho and MAPK signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0035418","count":2},{"id":"GO:0035994","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0007266","count":2}]},{"hash":"832634366622949222","title":"Immune signaling regulation and actin dynamics","description":"Several GO terms point to modulation of immune pathways (negative regulation of T cell receptor signaling, positive regulation of B cell chemotaxis, JAK and PKA signaling) together with actin cytoskeleton organization and endosomal protein localization. This suggests a cluster of proteins that fine-tune immune signaling while coordinating cytoskeletal remodeling and trafficking, rather than a single metabolic function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0050860","count":15},{"id":"GO:0010737","count":14},{"id":"GO:0042976","count":14},{"id":"GO:0030866","count":14},{"id":"GO:0046621","count":14}]},{"hash":"1432255506154526715","title":"Eye morphogenesis and epithelial development","description":"The top GO terms show a clear emphasis on eye formation (embryonic eye morphogenesis, camera-type eye development) and epithelial tissue morphogenesis (lung epithelial branching, thymus epithelium morphogenesis), suggesting these proteins collectively participate in organogenesis with a focus on ocular and epithelial tissues.","confidence":"High","size":16,"edges":23,"triangles":8,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0048048","count":11},{"id":"GO:0060441","count":10},{"id":"GO:0043010","count":10},{"id":"GO:0000122","count":9}]},{"hash":"1446581363632928541","title":"Ubiquitin-Dependent Proteolysis and TNF/NF-\u03baB Signaling","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein degradation (including SCF-dependent and ERAD pathways) and links to inflammatory signaling pathways (NF-\u03baB and TNF) along with regulation of apoptosis. This suggests the proteins function together in ubiquitin-proteasome\u2013mediated turnover that modulates inflammatory signaling and cell survival.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0031146","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0007250","count":6},{"id":"GO:1903265","count":6}]},{"hash":"907131378354202011","title":"Ubiquitin-Dependent Antiviral Immune Signaling","description":"The GO terms point to a coherent theme of ubiquitin-proteasome\u2013mediated protein degradation and ubiquitination, coordinating innate immune responses and antiviral defense through NF-kB and TNF signaling. While a single term about brain development appears, the dominant signals relate to ubiquitin-dependent regulation of antiviral immunity.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0070534","count":8},{"id":"GO:0031146","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":7}]},{"hash":"133920327558139536","title":"Ubiquitin-Dependent NF-kappaB Signaling Regulation","description":"The cluster is dominated by ubiquitination-related processes (protein ubiquitination, ubiquitin-dependent protein catabolic process, histone catabolic process, autoubiquitination, K6-linked ubiquitination) and NF-kappaB signaling modulation (activation of NF-kappaB-inducing kinase, positive regulation of canonical NF-kappaB signaling), with related links to TNF signaling and apoptosis. This suggests a cohesive role in ubiquitin-mediated protein turnover and regulation of NF-kappaB-driven responses.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:1903265","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0036205","count":6},{"id":"GO:0085020","count":6}]},{"hash":"549572735906090800","title":"Neuronal differentiation and cytoskeletal remodeling","description":"The top GO terms point to actin filament bundle assembly and cell migration, along with cerebellar granule cell differentiation and SNARE-related processes, suggesting a theme of cytoskeletal dynamics and vesicle trafficking supporting neuronal development and signaling. Some terms are obsolete, but the core signals cohere around neuronal differentiation and actin-driven remodeling. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070212","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0007205","count":4},{"id":"GO:2001275","count":4}]},{"hash":"189579991249163642","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042346","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2}]},{"hash":"861724826230823483","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008625","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0007628","count":2},{"id":"GO:0060179","count":2},{"id":"GO:1900025","count":2}]},{"hash":"1842919793336426725","title":"Renal development and epithelial remodeling","description":"The terms cluster around kidney-related processes: renal sodium ion absorption, ureteric bud branching morphogenesis, epithelial-to-mesenchymal transition, and cell adhesion, which together point to nephrogenesis and renal epithelial remodeling. Some terms (circadian regulation of gene expression, female pregnancy, respiratory system process) appear broader or pleiotropic, and mitochondrial protein import/inner membrane insertion and base-excision repair are less kidney-specific, possibly reflecting multi-function genes or annotation noise. Overall, the dominant theme is kidney development and epithelial dynamics.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070294","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0032922","count":2},{"id":"GO:0003016","count":2}]},{"hash":"483895685168626326","title":"Immune signaling and cell cycle regulation","description":"The terms point to innate and adaptive immune signaling (GM-CSF stimulus, LPS response, T cell receptor signaling) alongside cell cycle control (G1/S and G2/M transitions, mitotic re-entry, transcription). This suggests a cluster of proteins linking immune activation with regulation of cell proliferation, with some transcriptional and chromatin-related activity.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097011","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0071222","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0046626","count":3}]},{"hash":"2080617974797453273","title":"GPCR-Mediated Thermo-Pain Signaling","description":"The top GO terms cluster around sensory pain and temperature response, plus GPCR-related processes (internalization and signaling) and downstream effects on cAMP pathways and muscle relaxation. This suggests proteins in a GPCR-driven network that mediates thermosensory and nociceptive signaling with modulation of muscle activity, hence the label.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0051482","count":7},{"id":"GO:0002031","count":7}]},{"hash":"2100729983768511730","title":"Unknown","description":"The top GO terms cover very different processes (growth-factor response, pH elevation, histamine and neurotransmitter biosynthesis, pigmentation, thermotaxis, alkaloid response, glutamate catabolism, fibroblast migration, and methanofuran biosynthesis), with no clear unifying function. Thus a coherent, specific label can't be assigned.","confidence":"","size":16,"edges":43,"triangles":33,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071363","count":3},{"id":"GO:0051454","count":3},{"id":"GO:0001694","count":3},{"id":"GO:0048082","count":3},{"id":"GO:0043052","count":3}]},{"hash":"872395043682643179","title":"Fatty acid biosynthesis and elongation","description":"The top GO terms are dominated by fatty acid metabolism: unsaturated fatty acid biosynthetic process, long-chain fatty-acyl-CoA biosynthetic process, long-chain fatty acid biosynthetic process, and fatty acid elongation (mono- and polyunsaturated). While there are some development and endosomal transport terms present, the strongest signal centers on lipid biosynthesis, suggesting the cluster reflects a fatty acid production/elongation module. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032511","count":3},{"id":"GO:0033689","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0001886","count":2},{"id":"GO:0048794","count":2}]},{"hash":"539904080320355606","title":"Rho-actin dynamics and endosomal trafficking","description":"This cluster combines strong signals for Rho-regulated cytoskeletal remodeling and actin filament assembly with endosomal organization, receptor recycling, and SNARE regulation, pointing to coordinated cytoskeleton\u2013membrane trafficking. The presence of synaptic transmission and epithelial polarity terms suggests roles at cell interfaces (neuronal synapses, migrating cells, and polarized epithelia) where actin dynamics and endosomal trafficking converge. ","confidence":"High","size":16,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0060368","count":5},{"id":"GO:0051017","count":4},{"id":"GO:0007032","count":4},{"id":"GO:0001881","count":4}]},{"hash":"668077525164473799","title":"Embryonic Development and Tissue Morphogenesis","description":"This cluster centers on GO terms related to multicellular organism development, skeletal system development, spinal cord development, and skin development, suggesting a shared role in tissue formation and morphogenesis. Additional terms for microtubule-based movement and signaling (GTPase activity regulation, peptidyl-tyrosine phosphorylation) fit cellular dynamics during development, while ER-Golgi transport and ERAD reflect general protein processing in differentiating cells. Overall, the proteins appear to participate in developmental processes shaping tissues.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0021510","count":2}]},{"hash":"1258323204547892790","title":"Vesicle trafficking in neural development","description":"The top GO terms cluster around neural development (imaginal disc morphogenesis; radial glia\u2013guided migration) alongside vesicle-related processes (endocytosis regulation; synaptic vesicle uncoating; vacuolar membrane localization) and neurotrophic/metabolic signaling (BDNF response; insulin signaling regulation; starvation response), suggesting a cohesive role in vesicle dynamics and signaling during neural development. Despite no edges, the functional themes point to vesicle trafficking in developing neurons.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007480","count":2},{"id":"GO:0030100","count":2},{"id":"GO:0021816","count":2},{"id":"GO:0046626","count":2},{"id":"GO:0000747","count":2}]},{"hash":"557053828310936742","title":"Neural development and synapse assembly","description":"This cluster is dominated by GO terms for nervous system development, cell adhesion (homophilic/heterophilic), and positive regulation of synapse assembly, suggesting proteins involved in neuronal connectivity and synaptic organization. While there are additional terms for proteolysis, ossification, and immune processes, the core theme centers on neural development and synaptic adhesion/assembly.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007156","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0006508","count":7},{"id":"GO:0051965","count":6}]},{"hash":"942678830024884010","title":"GPCR Signaling in Enteric and Neural Development","description":"The dominant GO terms cluster around GPCR-mediated signaling, including activation of adenylate cyclase and ERK cascades, coupled with physiological outputs such as peristalsis, enteric nervous system development, pain perception, inflammatory responses, and regulation of blood pressure and thermogenesis. This suggests a cohesive theme of GPCR-driven signaling shaping gut-neural development and related homeostatic responses.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0072224","count":9},{"id":"GO:0007190","count":9},{"id":"GO:0048484","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0030432","count":9}]},{"hash":"357387591294482354","title":"Dopaminergic GPCR signaling regulation","description":"The top GO terms cluster around modulation of dopamine receptor signaling and related GPCR pathways, including negative regulation of adenylate cyclase activity and dopamine transport, pointing to dopaminergic neurotransmission and cAMP signaling control. Some terms (cell wall macromolecule catabolic process, DN2 thymocyte differentiation) seem less related and may reflect annotation noise, but the dominant theme is neuromodulatory GPCR signaling regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":16},{"id":"GO:0090075","count":16},{"id":"GO:0007194","count":16},{"id":"GO:0016998","count":16},{"id":"GO:0040015","count":16}]},{"hash":"562477613512848478","title":"Phototransduction and cardiac cAMP signaling","description":"This cluster is dominated by GO terms for visual perception and opsin signaling (phototransduction), plus cAMP signaling, calcium release, and regulation of cardiac processes. The co-occurrence of heart development and regulation of cardiac muscle contraction with photoreceptor signaling and adenylate cyclase activation suggests proteins involved in light-driven signaling that also interface with cAMP/calcium pathways governing cardiac function. The label captures the joint retina and cardiac signaling theme rather than a single narrow function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":9},{"id":"GO:0043950","count":7},{"id":"GO:0051281","count":7},{"id":"GO:0007190","count":7},{"id":"GO:0007507","count":7}]},{"hash":"852541465845763832","title":"Transmembrane ion and metabolite transport","description":"This cluster is dominated by GO terms for transporting ions (sodium, potassium, phosphate, nitrite, nitrate) and various metabolites (galactose, fucose, 4-hydroxyphenylacetate) across membranes, plus a term about loading neurotransmitters into synaptic vesicles. The common theme is membrane-embedded transport activity for ions and small molecules, with an additional vesicle-loading component, suggesting a coherent pool of transporter/vesicle-related functions. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0098700","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0015757","count":3}]},{"hash":"1427511929424096571","title":"Embryonic development and tissue morphogenesis","description":"This cluster centers on developmental differentiation and morphogenesis across multiple tissues (placenta, left-right patterning, cartilage, heart EMT, endocrine/pancreatic development), indicating a general theme of embryonic tissue development rather than a single pathway. Some terms reflect broader signaling or regulatory processes but do not override the overarching developmental pattern.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0003198","count":2}]},{"hash":"1559195995506053702","title":"Dopamine signaling regulation","description":"Most terms point to dopaminergic pathways: negative regulation of dopamine receptor signaling, GPCR-adenylyl cyclase signaling, and dopamine transport. A few terms appear unrelated (e.g., thymocyte differentiation, cell wall catabolic processes), but the dominant pattern supports a dopamine signaling modulation theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":15},{"id":"GO:0090075","count":15},{"id":"GO:0007194","count":15},{"id":"GO:0016998","count":15},{"id":"GO:0040015","count":15}]},{"hash":"2281169899712961767","title":"Neuronal pain signaling and locomotion","description":"The cluster\u2019s top terms cluster around neural signaling and pain-related processes: neuropeptide signaling, sensory perception of pain, regulation of dopamine signaling, and locomotory behavior, supported by membrane potential and calcium signaling changes. Immune-related terms like response to lipopolysaccharide and blood coagulation are present but appear peripheral to the main neural/pain/theme, which justifies a label focused on neuronal signaling and pain modulation linked to movement. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0051281","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0007218","count":4},{"id":"GO:0043547","count":4}]},{"hash":"331530188428212028","title":"Cardiovascular and Neural Signaling","description":"The top GO terms point to heart-related functions (heart development, cardiac muscle contraction) alongside neuronal processes (dendritic spine development, synaptic vesicle budding). Coupled with signaling pathway terms (Rho and PI3K/AKT signaling), the cluster seems to group proteins involved in cross-tissue signaling that influences both cardiac and neural functions. Immune-related terms appear but are less central to the core theme. Therefore, a label centered on cross-tissue signaling in heart and nervous system fits best.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0061000","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0008344","count":5},{"id":"GO:0016185","count":5}]},{"hash":"1555406329261962721","title":"Neural signaling and sensory processing","description":"Top terms cluster around neural development and sensory modulation, including cerebellar granule cell differentiation, conditioned taste aversion, regulation of sensory perception of pain, and serotonin metabolic process, along with intracellular signal transduction and receptor clustering. These indicate a functional theme centered on neural signaling and sensory processing, despite a few outlier terms that reflect broader or unrelated processes. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":3},{"id":"GO:0035556","count":3},{"id":"GO:0001661","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0043113","count":2}]},{"hash":"1165152209006634050","title":"Pro-inflammatory signaling and prostaglandin synthesis","description":"These proteins converge on inflammatory and immune-related functions: positive regulation of inflammatory response, cellular response to TNF, cytokine production, and complement activation, alongside prostaglandin biosynthesis. The presence of lipid mediator synthesis (prostaglandins) plus immune signaling suggests a core theme of inflammation and lipid-mediated signaling, with other terms possibly reflecting tissue contexts or shared metabolic support. Overall, this cluster appears best described as inflammatory signaling with prostaglandin involvement.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008544","count":3},{"id":"GO:0050729","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0001516","count":2},{"id":"GO:0001816","count":2}]},{"hash":"1044240522922380384","title":"Chromatin regulation and transcription control","description":"The top terms cluster around DNA-templated transcription and regulation of transcription by RNA polymerase II, with strong signals for chromatin-related processes (rDNA heterochromatin formation, telomere silencing, nucleosome density). Methylation activities (histone and arginine methylation) and rRNA methylation further point to chromatin organization and transcriptional control. A few terms (like cobalamin biosynthesis) are less related, but the core signal supports a chromatin/transcription-focused module.","confidence":"High","size":15,"edges":97,"triangles":360,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0009236","count":5},{"id":"GO:0031940","count":5},{"id":"GO:0060303","count":5}]},{"hash":"2200099202681254241","title":"Embryonic heart and muscle morphogenesis","description":"In this cluster, multiple terms point to heart development (sinus venosus morphogenesis, right ventricle formation), diaphragm and skeletal muscle differentiation (diaphragm development, myoblast proliferation regulation, skeletal muscle differentiation), and broad transcriptional regulation (transcription by RNA polymerase II, transcriptional activity modulated by glucose). The convergence on cardiac and skeletal muscle morphogenesis, with associated transcription control, suggests a coherent program governing embryonic cardiomuscular development rather than unrelated processes.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0003236","count":8},{"id":"GO:0003219","count":8},{"id":"GO:0070368","count":8},{"id":"GO:0032922","count":8}]},{"hash":"1716731115385567140","title":"Developmental transcription regulation","description":"The Top Terms show DNA-templated transcription and circadian regulation of gene expression, indicating transcriptional control. Additional morphogenesis terms (lens fiber cell differentiation, semicircular canal morphogenesis, outflow tract morphogenesis, ureteric bud development) point to transcriptional regulation acting across diverse developmental processes, suggesting a coherent theme of regulation of gene expression during development.","confidence":"High","size":15,"edges":89,"triangles":294,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0045872","count":8},{"id":"GO:0032922","count":6},{"id":"GO:0043433","count":6},{"id":"GO:0060038","count":5}]},{"hash":"136192810985196321","title":"Dopaminergic Synaptic Transmission and Drug Response","description":"GO terms are dominated by neural signaling and behavior, notably synaptic transmission in dopaminergic circuits and behavioral responses to addictive substances (morphine, cocaine). ERK1/2 cascade regulation and prostaglandin signaling further support a theme of signaling plasticity underlying reward and learning. Some terms (heart development, brain renin-angiotensin system) are less directly tied to neurons, but the prevailing pattern centers on neuronal communication and drug-induced behavioral modulation. Therefore the cluster is best described as a dopaminergic signaling and drug-response module.","confidence":"Medium","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":14},{"id":"GO:0002035","count":13},{"id":"GO:0008542","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0070374","count":13}]},{"hash":"1586230284121031748","title":"Rho-GTPase Signaling and Cytoskeletal Dynamics","description":"Top GO terms suggest a core theme of signaling pathways that regulate Rho/GTPase activity and cytoskeletal/membrane organization (e.g., microvillus assembly, protein dephosphorylation). The presence of angiogenesis and endothelial barrier terms points to vascular contexts, while synaptic transmission and social behavior hint at neural/immune signaling interfaces. Overall, the cluster seems to reflect coordinated signal transduction governing cytoskeletal remodeling across vascular, neural, and immune settings.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:2000670","count":4},{"id":"GO:0035176","count":4},{"id":"GO:0090630","count":3},{"id":"GO:0030033","count":3}]},{"hash":"2236266409573739857","title":"ECM remodeling and coagulation with redox regulation","description":"The cluster shows enrichment for extracellular matrix remodeling signals (negative regulation of collagen biosynthesis, hepatic stellate cell activation), heart development, and coagulation/platelet aggregation, plus redox/homeostasis and detoxification terms. This combination points to a cohesive theme of tissue remodeling and cardiovascular development coordinated with hemostasis and oxidative stress management.","confidence":"High","size":15,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":5},{"id":"GO:0070527","count":4},{"id":"GO:0051291","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0045454","count":3}]},{"hash":"1294487749269663933","title":"Stress-Responsive Metabolic Regulation","description":"The cluster contains terms tying redox balance and transcriptional/signaling regulation to a broad set of metabolic pathways (glucose/fructose catabolism, pyruvate fermentation to ethanol, Ehrlich pathway, lignin and antibiotic biosynthesis) and an immune-like response to lipopolysaccharide, suggesting a module where metabolism is coordinated with stress signaling and defense.","confidence":"Medium","size":15,"edges":70,"triangles":146,"max_degree":12,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0032496","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0046370","count":4}]},{"hash":"744526797283486921","title":"Unknown","description":"The top GO terms span innate immune response and defense against virus, but also include plant-related processes (photosynthesis, chlorophyll regulation) and diverse developmental and chromatin-related terms (male sex differentiation, fat pad development, ubiquitination, histone methylation, photoreceptor localization). This mixture across species and functions lacks a coherent, shared biological theme, so a single meaningful label is not apparent.","confidence":"","size":15,"edges":25,"triangles":15,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0045842","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0046661","count":4},{"id":"GO:0015979","count":4}]},{"hash":"2145282643847743449","title":"Glycosaminoglycan biosynthesis and sulfation","description":"The dominant terms point to sulfated proteoglycans: heparan sulfate and chondroitin sulfate biosynthesis, along with protein sulfation and sulfate metabolism. This suggests a cohesive function around assembly and modification of glycosaminoglycans and their sulfation state, with some additional links to xenobiotic response and hormone-related metabolism that can co-occur in related sulfur metabolism pathways. ","confidence":"Medium","size":15,"edges":5,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035690","count":6},{"id":"GO:0015012","count":4},{"id":"GO:0006805","count":4},{"id":"GO:0030206","count":4},{"id":"GO:0048702","count":4}]},{"hash":"437247895424547938","title":"Redox signaling and protein phosphorylation","description":"The cluster\u2019s top terms center on cellular response to hydrogen peroxide (oxidative stress) and protein autophosphorylation, with supporting terms for protein complex oligomerization and nucleotide biosynthesis, suggesting a cohesive theme of redox-responsive signaling and phosphorylation-driven regulation; several entries are obsolete GO terms, indicating some annotation noise but not negating the core connection.","confidence":"Medium","size":15,"edges":83,"triangles":241,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0046777","count":4},{"id":"GO:0050765","count":4},{"id":"GO:0061508","count":4}]},{"hash":"1622758864213101080","title":"Endothelial barrier formation and transcytosis","description":"The cluster shows a clear emphasis on endothelial barrier biology, with top terms for transcytosis, bicellular tight junction assembly, and establishment of the endothelial barrier. This points to proteins involved in forming and maintaining the vascular barrier, particularly in brain-related contexts, with additional neuronal development terms possibly reflecting broader tissue interactions or background signals.","confidence":"Medium","size":15,"edges":48,"triangles":64,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045056","count":4},{"id":"GO:0070830","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0071630","count":3},{"id":"GO:0070389","count":3}]},{"hash":"1783841420513997847","title":"Unknown","description":"The top GO terms are diverse, including immune cell chemotaxis (neutrophil and mast cell), xenobiotic response, and mitotic processes, plus a few unrelated terms like substantia nigra development. There isn\u2019t a single cohesive function uniting these terms, so a specific, intuitive label isn\u2019t apparent beyond Unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030593","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0090307","count":3}]},{"hash":"2268153347978773799","title":"Regulatory signaling and chromatin remodeling","description":"The top GO terms point to regulators of signaling and gene expression rather than a single metabolic pathway: dephosphorylation events, negative regulation of proteasomal degradation, transcription initiation-coupled chromatin remodeling, and responses to hormonal cues, plus some myelin-related processes. This suggests a broad role in controlling signaling pathways and chromatin dynamics across contexts, rather than a specific pathway. ","confidence":"Medium","size":15,"edges":55,"triangles":69,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":2},{"id":"GO:0031642","count":1},{"id":"GO:0045815","count":1},{"id":"GO:0071391","count":1},{"id":"GO:0035335","count":1}]},{"hash":"120694058505220349","title":"Melanosome Biogenesis and Cytoskeletal Dynamics","description":"This cluster is dominated by melanosome assembly and several cytoskeleton/polarity-related terms (actin branching, Cdc42 signaling, apical junction assembly, nuclear migration), suggesting a shared theme of pigment organelle formation coupled with cytoskeletal remodeling and cell polarity. Vesicle trafficking and organelle distribution terms further support a focus on intracellular transport and organization relevant to pigment-containing cells. ","confidence":"High","size":15,"edges":20,"triangles":13,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903232","count":14},{"id":"GO:0071338","count":14},{"id":"GO:0043297","count":14},{"id":"GO:0007097","count":14},{"id":"GO:0046579","count":14}]},{"hash":"2207991674014464155","title":"Unknown","description":"The top GO terms show a mix of diverse processes (DNA damage checkpoint signaling, transcription regulation, multiple transporters, reproductive and developmental processes, pH changes, and gastric secretion) with no clear shared function or pathway linking the proteins. This lack of a cohesive biological theme justifies an Unknown label.","confidence":"","size":15,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031573","count":2},{"id":"GO:1900490","count":2},{"id":"GO:0019532","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0030435","count":2}]},{"hash":"766415295754483450","title":"RNA processing and transcription regulation","description":"The top GO terms cluster around RNA metabolism: mRNA splicing, polyadenylation, mRNA stability regulation, and transcriptional control by RNA polymerase II, along with miRNA turnover. Although there are a couple of outlier terms related to carotene/isoprenoid biosynthesis, the dominant signal is RNA processing and transcription regulation, making this label representative for the group. ","confidence":"Medium","size":15,"edges":95,"triangles":340,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0010610","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0097222","count":3}]},{"hash":"714494324342547465","title":"Nuclear transcription and mRNA export","description":"The top GO terms cluster around DNA-templated transcription and negative regulation of transcription by RNA Polymerase II, plus mRNA export from the nucleus and related nucleocytoplasmic trafficking (ribosomal large subunit export, kinetochore localization). This points to a group of proteins involved in nuclear gene expression and RNA processing/export, with some ancillary roles in protein regulation and stress responses. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006406","count":5},{"id":"GO:0042176","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0006351","count":4}]},{"hash":"2117860106148063584","title":"Splicing and mRNA processing regulation","description":"The cluster shows strong signals for mRNA splicing via the spliceosome, splice site recognition, mRNA modification, and mRNA stabilization, along with regulation of mRNA stability in response to stress and assembly of the eIF4F translation initiation complex. Together these terms point to a coordinated role in RNA maturation and post-transcriptional control (splicing, processing, stability, and translation initiation), making the label a good representation of the cluster\u2019s function.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":12},{"id":"GO:0010610","count":9},{"id":"GO:1905663","count":8},{"id":"GO:0097010","count":8},{"id":"GO:0016556","count":8}]},{"hash":"815828301761396593","title":"RNA processing and translation initiation regulation","description":"The GO terms show strong signals for mRNA splicing and spliceosome regulation, mRNA modification and stabilization, splice site recognition, as well as assembly of translation initiation complexes and translation reinitiation. Together they point to a coordinated RNA-processing and translation-control module.","confidence":"High","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0002188","count":7},{"id":"GO:1901407","count":6}]},{"hash":"2272414000337454378","title":"DNA Damage Repair and UV Response","description":"The GO terms show a strong focus on nucleotide-excision repair (pyrimidine dimer repair, transcription-coupled repair) and UV-C response, pointing to a DNA damage repair/UV-stress theme; other terms (cell cycle regulation, innate immune response) likely reflect broader stress response connections.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3},{"id":"GO:1901666","count":3},{"id":"GO:0071157","count":3}]},{"hash":"693580387371991790","title":"Neuronal vesicle trafficking and exocytosis","description":"This cluster centers on SNARE complex assembly, vesicle fusion with Golgi and plasma membrane, and exocytic delivery of neurotransmitter receptors, along with ER\u2013Golgi transport and a link to long-term synaptic potentiation. The GO terms point to a coordinated secretory pathway governing synaptic vesicle trafficking and receptor insertion in neurons, rather than unrelated processes.","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":3},{"id":"GO:0007289","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0035493","count":2},{"id":"GO:0090161","count":2}]},{"hash":"869883756271230312","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0000462","count":3}]},{"hash":"760717728543183271","title":"Neuronal development and synaptic plasticity","description":"This cluster centers on neuronal growth and wiring (nervous system development, hippocampus development) and on synaptic signaling and strengthening (long-term potentiation, ERK cascade, Wnt signaling, PI signaling). The presence of actin cytoskeleton remodeling also supports changes in synaptic structure during plasticity. Overall, the proteins are best characterized as involved in neuronal development and synaptic function.","confidence":"High","size":15,"edges":99,"triangles":381,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0021766","count":5},{"id":"GO:0090263","count":5}]},{"hash":"2228390028324525292","title":"Regulation of cell growth and differentiation","description":"Top terms suggest a core theme of cell growth and fate control, integrating DNA replication (cell cycle), Hippo and Wnt signaling, apoptosis, and differentiation, with supporting roles for nuclear transport and proteasome regulation.","confidence":"Medium","size":15,"edges":5,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":13},{"id":"GO:0060044","count":10},{"id":"GO:0035329","count":10},{"id":"GO:0090263","count":10},{"id":"GO:0006915","count":10}]},{"hash":"459317441760886932","title":"Neural development and axon guidance","description":"The proteins are enriched for neuronal migration and axon guidance terms, including lateral motor column neuron migration, motor neuron axon guidance, and peripheral nervous system neuron axonogenesis, indicating a core theme of neural development and pathfinding. Additional GO terms on cell-matrix adhesion and sprouting angiogenesis fit within developmental processes, while platelet aggregation and LDL stimulus terms appear as less central associations. Overall, the cluster seems best described by neural development and axon guidance.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"wound healing","top_go_terms":[{"id":"GO:0097477","count":9},{"id":"GO:0070527","count":9},{"id":"GO:0007160","count":8},{"id":"GO:0008045","count":6},{"id":"GO:0048936","count":6}]},{"hash":"2172032193206215739","title":"Mitochondrial Electron Transport and ROS Regulation","description":"This cluster is enriched for terms related to the mitochondrial electron transport chain (ubiquinol to cytochrome c; cytochrome c to oxygen), hydrogen peroxide metabolism and its regulation, and apoptotic signaling via cytochrome c. A photosynthesis term appears but the dominant pattern ties to electron transport and reactive oxygen species control, suggesting a mitochondria/ROS-focused function cluster.","confidence":"High","size":15,"edges":93,"triangles":318,"max_degree":14,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0034465","count":7},{"id":"GO:0006915","count":7},{"id":"GO:0018063","count":7},{"id":"GO:0015979","count":7},{"id":"GO:0008635","count":7}]},{"hash":"1611964385430511402","title":"Actin Cytoskeleton Dynamics and Cell Polarity","description":"The top GO terms cluster around actin nucleation and filament formation, regulation of cell shape, and formin-mediated actin assembly, plus processes related to centrosome localization and ER/polarization. The ureteric bud invasion hint links to actin-driven morphogenesis, while spindle localization indicates broader cytoskeletal coordination. Together, these point to a cohesive group of proteins involved in actin cytoskeleton assembly/remodeling and associated polarity.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045010","count":3},{"id":"GO:0010467","count":2},{"id":"GO:0008360","count":2},{"id":"GO:2000251","count":2},{"id":"GO:0072092","count":2}]},{"hash":"155929291245039039","title":"Post-transcriptional mRNA processing & translation initiation","description":"The top terms cluster around mRNA processing steps (polyadenylation, splicing, mRNA modification, stability regulation) and assembly/activation of the translation machinery (preinitiation complex formation, eIF4F assembly, translation reinitiation), indicating a module that coordinates RNA maturation with translation initiation.","confidence":"High","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":11},{"id":"GO:0010610","count":10},{"id":"GO:1901407","count":10},{"id":"GO:0045292","count":10},{"id":"GO:0001731","count":10}]},{"hash":"682080878095593856","title":"Innate immunity and actin cytoskeleton remodeling","description":"The terms indicate a module where innate immune signaling is coupled to actin dynamics, including microspike assembly, actin crosslinking, and Rho/JNK pathway regulation, suggesting roles in immune cell adhesion, polarity, and motility rather than a purely structural or developmental function. This coherent theme across several terms supports the label as representative of the cluster\u2019s function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0046328","count":8},{"id":"GO:0007155","count":7},{"id":"GO:0071963","count":7},{"id":"GO:0030035","count":7}]},{"hash":"1717504086169286412","title":"Cytoskeletal dynamics and endocytosis","description":"Reasoning: The terms cluster around cytoskeletal remodeling (GTPase activity regulation, actin rearrangement, barbed-end capping, microtubule movement, centrosome localization) and vesicle trafficking (clathrin-dependent endocytosis), with supporting involvement of ubiquitination and apoptosis. This points to a group of proteins that coordinate cytoskeletal dynamics with endocytic processes, potentially linked to broader cellular remodeling and signaling contexts.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006915","count":4},{"id":"GO:2000251","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0060292","count":3}]},{"hash":"2134710781194265522","title":"Embryogenesis and Tissue Morphogenesis","description":"These proteins cluster around embryonic development and tissue formation: placental/endocrine development, trophoblast differentiation, left-right patterning, EMT in heart formation, cartilage morphogenesis, pancreatic cell development, and collagen/ECM remodeling. A few immune-related terms (complement activation) may be incidental to morphogenesis. Overall, it represents a cohesive Embryogenesis and Tissue Morphogenesis cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0060972","count":6}]},{"hash":"711992836058089408","title":"Innate immune signaling","description":"Top GO terms are dominated by immune signaling: positive regulation of canonical NF-kappaB signaling, TLR4 signaling, interferon-beta production, and innate immune response, indicating a core set of proteins involved in NF-kB\u2013 and TLR-mediated immune signaling. A few terms relate to neural development or cell cycle, suggesting possible pleiotropy, but the prevailing theme across the cluster is innate immune signaling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0007098","count":3},{"id":"GO:0043627","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0034145","count":3}]},{"hash":"183334985434484860","title":"Lipid and secondary metabolite biosynthesis","description":"The top GO terms cluster around diverse biosynthetic processes for lipids and small molecules (poly-hydroxybutyrate, 3-keto-sphinganine, mycolic acid, retinoic acid, testosterone, tropane alkaloids, etc.), with a few related drug- or antibiotic-response terms. This suggests the proteins are enriched for enzymes and regulators of lipid/small-molecule metabolite production and related chemical responses, rather than a single narrow function, making a label centered on lipid and secondary metabolite biosynthesis appropriate.","confidence":"Medium","size":15,"edges":11,"triangles":1,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0042619","count":7},{"id":"GO:0031427","count":6},{"id":"GO:0030324","count":6},{"id":"GO:0009710","count":6}]},{"hash":"484619175630221938","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001731","count":6},{"id":"GO:0002188","count":6},{"id":"GO:0071456","count":5},{"id":"GO:0006446","count":5},{"id":"GO:0075525","count":5}]},{"hash":"2283712373865630332","title":"Synaptic vesicle exocytosis and priming","description":"GO terms center on vesicle trafficking and fusion, especially regulation of synaptic vesicle exocytosis and synaptic vesicle priming, with brain development supporting a neuronal context. The acrosome reaction and mating projection growth hints at secretory exocytosis in reproductive cells, while phosphatidylinositol signaling and responses to mechanical stimuli reflect signaling pathways that regulate vesicle trafficking.","confidence":"High","size":15,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":4},{"id":"GO:0031384","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0071260","count":4}]},{"hash":"1787817931527104411","title":"Neurodevelopment and Visual System Signaling","description":"The cluster shows a strong emphasis on neural development and sensory processing, with terms like visual perception, axonogenesis, long-term synaptic potentiation, and excitatory postsynaptic potential. Additional items such as multicellular organism development and heart development suggest broader developmental roles, while a plant-specific ABA signaling term may reflect annotation overlap or cross-annotation. Overall, the core theme centers on neural development and visual/sensory signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":11},{"id":"GO:0000086","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0007409","count":10},{"id":"GO:0001525","count":10}]},{"hash":"1690896155739277233","title":"ECM remodeling and angiogenesis","description":"These proteins cluster around extracellular matrix dynamics and blood vessel formation: hyaluronan metabolic process, cell-matrix adhesion, positive regulation of angiogenesis, and positive regulation of metallopeptidase activity. Rho signaling further supports cytoskeletal and adhesion remodeling, tying the theme together. Some synaptic receptor clustering signals may reflect shared signaling machinery but do not redefine the core ECM/angiogenesis-related theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043113","count":13},{"id":"GO:0035418","count":12},{"id":"GO:0071333","count":12},{"id":"GO:0050830","count":12},{"id":"GO:0030212","count":12}]},{"hash":"1613390295036840931","title":"Motor neuron development and cytoskeletal dynamics","description":"The cluster\u2019s top GO terms center on neural development and cytoskeletal remodeling, including motor neuron migration/differentiation, spinal cord motor neuron fate specification, ectoderm formation, and actin filament depolymerization with cell-matrix adhesion. This points to a shared theme of neural development intertwined with cytoskeletal changes. A few terms (platelet aggregation, sulfur oxidation, slow endocytic recycling) seem less connected and may reflect annotation noise. Overall, the core theme is neural development with cytoskeletal remodeling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":4},{"id":"GO:0070527","count":4},{"id":"GO:0097477","count":4},{"id":"GO:0019417","count":3},{"id":"GO:0032458","count":3}]},{"hash":"793722826011805591","title":"Ubiquitin-Dependent Proteolysis & Circadian Regulation","description":"Most represented GO terms are ubiquitin-dependent protein catabolic process and protein polyubiquitination, with a strong signal for regulation of circadian rhythm. This suggests the cluster centers on ubiquitin-mediated protein turnover, possibly under circadian control. Other terms like innate immune response or antiviral defense appear but are likely indirect through shared ubiquitin-related pathways; the lack of network edges implies functional coherence inferred from GO annotations rather than interaction data.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0042752","count":10},{"id":"GO:0000209","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0045087","count":6}]},{"hash":"2305601529405986135","title":"Brain and Inner Ear Development","description":"The cluster is strongly enriched for terms related to neural and sensory organ development, including inner ear morphogenesis/development, brain segmentation, dopaminergic neuron differentiation, neuron migration, and rhombomere 5 development, indicating a cohesive neural/sensory developmental program. Some non-neural terms appear (e.g., digestive tract, chondrocyte differentiation), but the dominant signal centers on brain and inner ear formation.","confidence":"High","size":15,"edges":38,"triangles":16,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032330","count":10},{"id":"GO:0042472","count":10},{"id":"GO:0048839","count":10},{"id":"GO:0021571","count":10},{"id":"GO:0035284","count":10}]},{"hash":"1388872967294610103","title":"Neural signaling and development pathways","description":"This cluster is enriched for terms tied to nervous system development and nerve impulse transmission, alongside multiple signaling pathways (PI3K/AKT, Roundabout/Robo, Hedgehog/Smoothened, and T cell receptor signaling) and related processes such as cell\u2013matrix adhesion and endosome transport. The convergence of neural development, neuronal signaling, and associated signaling cascades suggests these proteins function together in neural signal transduction and development, with some involvement in trafficking and adhesion as supporting features.","confidence":"High","size":15,"edges":88,"triangles":279,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043491","count":8},{"id":"GO:0042517","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0001822","count":8},{"id":"GO:0035385","count":8}]},{"hash":"686314090018255821","title":"Signal Transduction and Immune Regulation","description":"The top terms point to core signaling and regulatory processes, including GPCR signaling, NOD2 signaling, NF-kappaB activity regulation, and protein ubiquitination, suggesting a cluster of proteins that modulate signaling networks and immune pathways. Some terms also touch on sensory perception and neuronal development, indicating broader modulation of signaling rather than a single pathway. This supports a label focused on signaling regulation with immune context.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0098907","count":6},{"id":"GO:0010745","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0070431","count":6}]},{"hash":"1209884601619301840","title":"ECM adhesion and immune signaling in development","description":"These proteins appear linked to extracellular matrix adhesion and remodeling (cell-matrix and cell-cell adhesion; hyaluronan biosynthesis) central to tissue development, alongside immune-related activities (complement activation via lectin pathway; response to LPS; T cell apoptosis). The presence of mechanotransduction and endocrine signals (thyroid hormone generation) suggests coordinated signaling among mechanical cues, development, and immune modulation, supporting a theme of ECM-adhesion\u2013driven developmental processes with immune involvement.","confidence":"Medium","size":15,"edges":31,"triangles":24,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007275","count":10},{"id":"GO:0007157","count":9},{"id":"GO:0007160","count":9},{"id":"GO:0001867","count":9},{"id":"GO:0006590","count":9}]},{"hash":"566620692822976675","title":"Axon guidance and neural development signaling","description":"The cluster features terms tied to neural development and connectivity, notably Roundabout signaling (Slit-Robo), axonal fasciculation, and otolith morphogenesis, alongside signaling pathways like ERK/MAPK, PI3K, and Rho regulation. While there are some immune-related terms, the strongest, recurrent theme is neural development and axon guidance, suggesting this cluster centers on signaling events governing nervous system patterning and connectivity.","confidence":"Medium","size":15,"edges":6,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043552","count":7},{"id":"GO:0050830","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0035023","count":6}]},{"hash":"1007201970593582634","title":"Cardiac Development and GPCR Signaling","description":"This cluster is dominated by GO terms tied to heart development, cardiac muscle contraction, and GPCR signaling (acetylcholine and tachykinin receptors), suggesting a coherent focus on cardiovascular signaling and heart function; other terms reflect broader signaling regulation and development, but cardiovascular-related terms are most prominent.","confidence":"High","size":15,"edges":41,"triangles":12,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0001957","count":7},{"id":"GO:0007601","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0043951","count":6}]},{"hash":"1964586518603003036","title":"Unknown","description":"The top GO terms cover a broad, diverse set of cellular processes (cell migration, muscle stretch response, fat cell differentiation, cell cycle, telomere maintenance) with no single unifying function. Because there isn\u2019t a coherent shared pathway or molecular role among the terms, a specific, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0035994","count":4},{"id":"GO:0032212","count":4},{"id":"GO:0007205","count":3}]},{"hash":"2218224571651741699","title":"Unknown","description":"Top terms point to a mix of nuclear processes (meiotic cell cycle, homologous recombination repair, DNA replication), cytoskeletal movement (actin filament-based movement), and membrane signaling (GPCR internalization, thrombin receptor signaling) with regulatory notes on Ras signaling and membrane tubulation. The lack of connections between proteins and the breadth of functions suggest no single cohesive theme binding the cluster. ","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051321","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0030048","count":2},{"id":"GO:0001759","count":2},{"id":"GO:0046580","count":2}]},{"hash":"728004503748982419","title":"Neuromuscular signaling and ciliogenesis cluster","description":"The top GO terms indicate neuromuscular processes (muscle contraction regulation via calcium release, denervation response, muscle attachment, neurotransmitter secretion) alongside centriole/ciliogenesis-related terms and cytoskeletal regulation (Arp2/3). This suggests a cluster spanning neuromuscular signaling with skeletal/ciliary architecture and cytoskeletal organization, hence the combined label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014809","count":2},{"id":"GO:0014894","count":2},{"id":"GO:0021629","count":2},{"id":"GO:0016203","count":2},{"id":"GO:0098535","count":1}]},{"hash":"1014863986374292704","title":"Organ development and tissue morphogenesis","description":"The top GO terms center on maturation and morphogenesis across multiple organs (ureter, lung, blood vessels, heart structures) and on cell adhesion and polarity, with some neural development terms, suggesting a cluster of proteins involved in coordinated tissue formation rather than a single molecular function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035799","count":4},{"id":"GO:0060489","count":4},{"id":"GO:0016339","count":4},{"id":"GO:0001955","count":4},{"id":"GO:1904938","count":4}]},{"hash":"1218585323061342662","title":"Myoblast Fusion and Cell Migration Regulators","description":"Based on the GO terms, the cluster is enriched for processes related to muscle development and cell motility, especially positive regulation of myoblast fusion and fibroblast migration, plus locomotory behavior. Supporting terms on smooth muscle proliferation, protein processing in the ER, glycosylation, and oxidative stress response suggest broader cellular homeostasis roles, but the dominant signals point to muscle formation and cell movement regulation.","confidence":"Medium","size":15,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0010763","count":3},{"id":"GO:0008344","count":2},{"id":"GO:0051260","count":2},{"id":"GO:1901741","count":2}]},{"hash":"1501169802889665569","title":"Developmental differentiation and energy metabolism","description":"The cluster includes GO terms tied to developmental fate decisions in sensory structures (wing cell fate specification, cone cell fate commitment, spermatid differentiation) and terms related to protein maturation and the unfolded protein response (EGFR ligand maturation, ER retrotranslocation, cellular response to unfolded protein). It also contains mitochondrial respiration terms (aerobic respiration, proton transmembrane transport, mitochondrial electron transport). Together these suggest proteins involved in coordinating differentiation processes with cellular energy production and proteostasis, rather than a single narrow function. Some terms (e.g., NK cell regulation) are less aligned, but the dominant theme is development linked to metabolism and protein quality control.","confidence":"Medium","size":15,"edges":68,"triangles":144,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035311","count":4},{"id":"GO:0038005","count":4},{"id":"GO:1904211","count":4},{"id":"GO:0034620","count":4},{"id":"GO:0042676","count":4}]},{"hash":"1226971498083053291","title":"Unknown","description":"The top GO terms span ubiquitin-dependent protein turnover, immune signaling, muscle development, kidney morphogenesis, and even plant hormone signaling, with no single cohesive function linking all terms. Because the cluster covers multiple divergent biological themes, a specific, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0050853","count":8},{"id":"GO:0045214","count":7},{"id":"GO:0002467","count":6},{"id":"GO:0009742","count":6}]},{"hash":"58963825975565352","title":"RNA Pol II Transcription Regulation","description":"This cluster is dominated by GO terms for regulation of transcription by RNA polymerase II (positive and negative) and DNA-templated transcription, pointing to a core theme of transcriptional control. The remaining terms (developmental processes like trophoblast differentiation, endothelial barrier establishment, multicellular growth, and immune responses) likely reflect downstream effects and contexts where transcriptional regulation is key. Overall, the shared function appears to be transcriptional regulation by RNA Pol II.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045944","count":5},{"id":"GO:0008630","count":4},{"id":"GO:0060707","count":4},{"id":"GO:1903142","count":4},{"id":"GO:0006958","count":4}]},{"hash":"1578555717557695251","title":"Ubiquitin-dependent protein degradation","description":"The top GO terms show ubiquitin-dependent protein catabolic process and protein ubiquitination as dominant annotations, indicating the cluster largely comprises proteins involved in tagging and degrading proteins via the ubiquitin-proteasome system. Additional terms touch on regulation of immune and cell processes, which may reflect pleiotropic roles of these proteins, but the core signal is ubiquitination and proteolysis.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0033280","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0051260","count":6},{"id":"GO:0098907","count":5}]},{"hash":"2086707070100934199","title":"Unknown","description":"The top GO terms cover transcription, immune signaling, viral processes, and cellular structures, with no single cohesive functional theme tying all proteins together. This spread suggests the cluster does not reflect a specific, identifiable biological function.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0071364","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0001782","count":2},{"id":"GO:1902064","count":2}]},{"hash":"1567125142671774755","title":"Skin inflammation and ECM remodeling","description":"The top GO terms point to inflammatory signaling (positive regulation of neutrophil extravasation, cellular response to interleukin-1 and TNF, monocyte activation, TNF response) together with skin- and ECM-related processes (keratinocyte differentiation, integrin-mediated cell-cell adhesion, collagen fibril organization) and Notch signaling. This pattern suggests a coordinated response in skin tissue involving immune cell recruitment and remodeling of the extracellular matrix, rather than a single enzyme-centric function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:2000391","count":9},{"id":"GO:0071347","count":9},{"id":"GO:0071356","count":9},{"id":"GO:0030216","count":9},{"id":"GO:0010042","count":9}]},{"hash":"1961186067011720290","title":"Neural and craniofacial development","description":"Reason: Top GO terms are dominated by brain/forebrain development, neural tube closure, and face development, indicating involvement in neural and craniofacial morphogenesis, with supporting signaling terms (ERK cascade, phosphorylation, GTPase activity).","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0070374","count":4}]},{"hash":"1482687581112158627","title":"Dopamine signaling regulators","description":"The top GO terms concentrate on negative regulation of dopamine receptor signaling and related GPCR-cAMP pathways, including dopamine transport and acetylcholine receptor signaling, suggesting the cluster consists of regulators of dopaminergic signaling. Some terms also touch on neural development and immune differentiation, implying broader regulatory roles, but the dominant theme is modulation of dopaminergic/GPCR signaling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":14},{"id":"GO:0090075","count":14},{"id":"GO:0007194","count":14},{"id":"GO:0016998","count":14},{"id":"GO:0040015","count":14}]},{"hash":"1342151845508766760","title":"Dopaminergic GPCR Signaling Modulation","description":"The top terms cluster around dopamine receptor signaling, GPCR-mediated control of adenylate cyclase activity, and dopamine transport, indicating a theme of dopaminergic signal modulation and cAMP pathways. A few terms relate to neural development or immune differentiation, which may reflect broader roles, but the dominant signal is dopaminergic GPCR regulation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":15},{"id":"GO:0090075","count":15},{"id":"GO:0007194","count":15},{"id":"GO:0016998","count":15},{"id":"GO:0040015","count":15}]},{"hash":"425042032332098262","title":"GPCR-Mediated Neuromodulatory Signaling","description":"The top terms cluster around G protein-coupled receptor signaling and its downstream effects, including neuropeptide signaling, ERK cascade activation, and modulation of dopamine receptor signaling, with related roles in blood pressure regulation. A single term for the electron transport chain appears as noise relative to the core GPCR/neuromodulatory theme, so the dominant connection is GPCR-driven signaling and neuromodulation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":7},{"id":"GO:0033861","count":6},{"id":"GO:0007218","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0045777","count":6}]},{"hash":"1596444656017932883","title":"Dopaminergic GPCR Signaling and Regulation","description":"The top terms cluster around dopamine receptor signaling, GPCR-mediated control of adenylate cyclase, and dopamine transport, with supporting terms tied to cortical interneuron migration and neural development. Despite one outlier term related to cell wall metabolism, the dominant theme is neuromodulatory GPCR signaling and dopaminergic regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035625","count":15},{"id":"GO:0060160","count":14},{"id":"GO:0090075","count":14},{"id":"GO:0007194","count":14},{"id":"GO:0016998","count":14}]},{"hash":"1939859280763301111","title":"Chromatin modification and transcription regulation","description":"The top GO terms are dominated by histone acetylation events (H4, H3, H2A) and DNA-templated transcription/regulation, indicating proteins involved in chromatin modification and control of gene expression; ancillary terms like meiotic cell cycle and microtubule nucleation are minor in this context.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043981","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0043968","count":2}]},{"hash":"1985402470295839200","title":"Wnt signaling and telomere maintenance","description":"The proteins are enriched for the Wnt signaling pathway along with multiple telomere-related processes (telomere capping, telomere maintenance, telomeric region localization), suggesting a functional link between Wnt signaling and telomere regulation. Additional terms related to spindle assembly and hepatocyte apoptosis point to broader cell-cycle and survival roles, but the core theme appears to be Wnt activity intersecting with telomere maintenance.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":5},{"id":"GO:0097284","count":5},{"id":"GO:1904743","count":4},{"id":"GO:0070212","count":4},{"id":"GO:0051225","count":4}]},{"hash":"549782434131650478","title":"Unknown","description":"The top GO terms cover pain sensing, vesicle and SNARE regulation, transcription and mRNA stability, inflammation, hormone secretion, telomere regulation, PARylation, foam cell differentiation, and spindle assembly. This broad mix shows no single coherent biological function or pathway linking the proteins, suggesting the cluster is heterogeneous or not representing a unified process.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":5},{"id":"GO:0035544","count":5},{"id":"GO:0000083","count":5},{"id":"GO:1904743","count":5},{"id":"GO:0070212","count":5}]},{"hash":"1084922760210804115","title":"Telomere maintenance and telomere region localization","description":"The top GO terms are dominated by telomere-related processes, including positive and negative regulation of telomere maintenance/capping and localization to the telomeric region, suggesting the cluster centers on telomere biology. While a few other terms (e.g., spindle assembly, signaling) appear, the telomere-associated terms are most represented, supporting a telomere-focused theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:1904743","count":3},{"id":"GO:0070212","count":3},{"id":"GO:0010745","count":3},{"id":"GO:0051225","count":3}]},{"hash":"1147324658809768929","title":"TLR signaling and immune regulation","description":"This cluster is best described by Toll-like receptor signaling activity, including MyD88-dependent TLR4 signaling and pathways for TLR2, TLR4, and TLR7. The prominence of these terms suggests the proteins batch into an innate immune signaling module. Additional terms related to transcription regulation and immune modulation (e.g., negative regulation of IL-6 production and B cell activation) imply the cluster centers on signaling that modulates immune responses rather than a single downstream effector function. Overall, the core theme is TLR-mediated immune signaling with regulatory context.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035660","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0007527","count":2},{"id":"GO:1900165","count":1},{"id":"GO:0034134","count":1}]},{"hash":"584335410236518872","title":"Intracellular vesicle trafficking and polarity organization","description":"Most top GO terms point to intracellular protein transport and vesicle trafficking between ER, Golgi, and endosomes, plus terms related to apical polarity and microvilli/terminal web organization, suggesting a cohesive theme of the cellular transport machinery and polarity establishment. Some terms (DNA-templated transcription, intestinal glucose absorption, mitotic cell cycle) are more peripheral or context-specific, but do not override the dominant trafficking/polarity signal.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0032532","count":2},{"id":"GO:0051661","count":2},{"id":"GO:1902896","count":2}]},{"hash":"608510453005936414","title":"Embryonic placental and mesoderm development","description":"The top GO terms converge on embryogenesis, especially placental/trophoblast development and mesoderm-derived morphogenesis, including left-right patterning, palate formation, and EMT in cardiac cushions.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060806","count":13},{"id":"GO:0035270","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0060972","count":13}]},{"hash":"1006805196209405294","title":"Neurodevelopment and sensory organ morphogenesis","description":"The terms point to neural development and sensory organ formation: axonogenesis in projection neurons, hippocampal development, neuron migration, and sound perception, plus lens morphogenesis and cilium assembly. A few terms are generic or obsolete, but the dominant theme is neurodevelopment and sensory organ morphogenesis.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021952","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0045071","count":2}]},{"hash":"1034644089876688025","title":"Neural Development and Myelination","description":"The top GO terms cluster around nervous system development, nerve impulse transmission, and myelination, with additional cell adhesion terms related to neural connectivity. Hedgehog signaling (Smoothened) and bone ossification are present but appear secondary to neural development signals, supporting a broader developmental context rather than a strictly bone or cardiac-focused group. This makes Neural Development and Myelination a concise, representative label for the cluster.","confidence":"Medium","size":14,"edges":75,"triangles":215,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0007156","count":5},{"id":"GO:0086091","count":4}]},{"hash":"244360919391355047","title":"Immune Signaling and Actin Dynamics","description":"Top GO terms suggest regulation of immune signaling (negative IL-2 production, JAK activation, B cell chemotaxis) and remodeling of the cortical actin cytoskeleton, with additional links to endosome localization and development-related processes. This points to a coordinated set of regulators balancing signal transduction and cytoskeletal dynamics in immune and developmental contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0046621","count":9},{"id":"GO:1900041","count":6},{"id":"GO:0010737","count":5},{"id":"GO:0042976","count":5},{"id":"GO:0030866","count":5}]},{"hash":"897535643302754853","title":"ERAD and Secretory Pathway Regulation","description":"The top GO terms cluster around ER-associated degradation (ERAD), its regulation, and pathways related to protein trafficking and exosomal secretion, plus signals involved in membrane/cytoskeletal organization (microvilli/brush border) and growth signaling. While there are some peripheral terms tied to sensory hair cells and transcription, the strongest common function appears to be protein quality control and trafficking along the secretory pathway in specialized epithelia. ","confidence":"Medium","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0014883","count":3},{"id":"GO:0030433","count":3},{"id":"GO:1904293","count":2},{"id":"GO:1904378","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2054667887902789983","title":"Neural crest migration and axon guidance","description":"The GO terms cluster around neural crest\u2013derived development and neural connectivity: neural crest cell migration, sympathetic and branchiomotor neuron axon guidance, trigeminal nerve organization, semaphorin-plexin signaling in axon guidance, and Rho signaling regulation, with heart development often linked to neural crest contributions. This cohesive theme points to neural crest\u2013driven development and axon pathfinding as the core function of the group.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0010765","count":7},{"id":"GO:0097491","count":6},{"id":"GO:0036486","count":6},{"id":"GO:0043552","count":6},{"id":"GO:1902287","count":6}]},{"hash":"1757342646035846552","title":"Developmental Signaling and Immune Regulation","description":"This cluster shows enrichment for developmental signaling pathways (Smoothened/hedgehog signaling, brain and kidney development, ossification) alongside immune signaling (positive regulation of interferon production, T cell receptor signaling), suggesting proteins involved in coordinating developmental processes with immune-related signaling rather than a single dedicated function.","confidence":"Medium","size":14,"edges":21,"triangles":8,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032729","count":9},{"id":"GO:2000300","count":8},{"id":"GO:0031384","count":8},{"id":"GO:0007420","count":8},{"id":"GO:0010796","count":8}]},{"hash":"1751682042307693623","title":"Ephrin signaling and axon guidance","description":"The top GO terms point to ephrin receptor signaling, axonogenesis/axon extension, and ERK signaling, all central to neuronal development and axon pathfinding. Terms like hippocampus development reinforce a neural context. While there are a few non-neuronal terms (e.g., T cell signaling, protein stability regulation), the dominant theme is neuronal signaling and guidance during development, especially via ephrin pathways and ERK cascades. Confidence: High","confidence":"","size":14,"edges":31,"triangles":13,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048013","count":13},{"id":"GO:0033138","count":13},{"id":"GO:0046827","count":13},{"id":"GO:0031532","count":13},{"id":"GO:0050852","count":13}]},{"hash":"2201339045445786479","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071279","count":3},{"id":"GO:0010666","count":3},{"id":"GO:0002027","count":3},{"id":"GO:0006094","count":3},{"id":"GO:0006351","count":2}]},{"hash":"429158241929757760","title":"Spliceosome-Mediated mRNA Processing","description":"The cluster is strongly enriched for splicing- and mRNA metabolism-related GO terms (mRNA splicing via spliceosome, regulation of splicing, mRNA stabilization, mRNA modification, and stress-related mRNA stability regulation), suggesting a coherent function in post-transcriptional processing and stability controlled by the spliceosome.","confidence":"High","size":14,"edges":76,"triangles":209,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":11},{"id":"GO:0010610","count":11},{"id":"GO:0006378","count":11},{"id":"GO:0000381","count":10},{"id":"GO:1905663","count":9}]},{"hash":"1284365822945692521","title":"RNA Splicing and mRNA Stability Regulation","description":"This cluster centers on regulation of mRNA processing, including spliceosome-mediated splicing (both positive and negative regulation), mRNA stability and modification, and splice-site recognition, along with a link to translation initiation complex assembly. Together, these terms indicate a cohesive post-transcriptional gene regulation module involving splicing regulators and mRNA processing factors.","confidence":"High","size":14,"edges":45,"triangles":65,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":10},{"id":"GO:0048026","count":9},{"id":"GO:0048025","count":9},{"id":"GO:0031047","count":9},{"id":"GO:1905663","count":8}]},{"hash":"1273117056918775041","title":"DNA Damage Response and Translation Regulation","description":"The cluster is dominated by translation and ribosome biogenesis terms (e.g., GO:0006412; GO:0042273) and includes transcription-related terms (GO:0032784; GO:0006354), plus several DNA damage response signals (e.g., gamma radiation response; p53-mediated pathways). This suggests a cohesive group of proteins involved in core gene expression (translation and transcription) that are linked to DNA damage signaling and apoptotic responses, rather than a single isolated process.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0042273","count":5},{"id":"GO:0031564","count":5},{"id":"GO:0071480","count":4},{"id":"GO:1902164","count":4}]},{"hash":"391889197416902829","title":"Developmental cell-cycle signaling","description":"The terms point to coordination of organismal development (multicellular development, skin development) with cell proliferation (mitotic cell cycle, DNA replication) and signaling regulation (kinase activity, GTPase activity, autophosphorylation), along with related processes like mRNA transport and hypoxia response, suggesting a cluster of proteins involved in developmental growth and signaling control.","confidence":"High","size":14,"edges":19,"triangles":11,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0006260","count":5},{"id":"GO:0051028","count":5},{"id":"GO:0043588","count":5}]},{"hash":"1167419899923385290","title":"Microtubule-based mitosis and nuclear migration","description":"The top GO terms cluster around microtubule dynamics that drive spindle assembly/orientation, chromosome alignment during mitosis and meiosis, and nuclear movements (including karyogamy-related migration), with some development-related terms likely reflecting broader cytoskeletal roles. This supports a cohesive label centered on microtubule-driven mitotic/nuclear processes.","confidence":"High","size":14,"edges":17,"triangles":9,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0031534","count":9},{"id":"GO:0032487","count":9},{"id":"GO:0000742","count":9},{"id":"GO:0007080","count":9},{"id":"GO:0000743","count":9}]},{"hash":"1621299713574707538","title":"RNA Splicing and Translation Initiation Machinery","description":"The cluster is dominated by GO terms for spliceosome-mediated mRNA processing (alternative splicing, mRNA modification, splicing via spliceosome) and for the assembly/activation of translation initiation complexes (preinitiation complex formation, eIF4F complex assembly, translation initiation and reinitiation). This suggests proteins in the cluster function at the intersection of RNA processing and the initiation of translation, with a few developmental or regulatory terms present as less central signals.","confidence":"High","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0007480","count":3},{"id":"GO:0045671","count":3}]},{"hash":"273492026790013939","title":"Fatty acid oxidation and carnitine metabolism","description":"The top GO terms cluster around fatty acid catabolism (beta-oxidation, acyl-CoA involvement) and carnitine-related transport and biosynthesis, pointing to a core module of lipid metabolism and energy production. Some entries also reflect metabolic stress responses (starvation, cold) that commonly accompany shifts in fatty acid utilization.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033540","count":2},{"id":"GO:0019254","count":2},{"id":"GO:0009791","count":2},{"id":"GO:0042594","count":2},{"id":"GO:0009409","count":2}]},{"hash":"1847895608626217749","title":"Ubiquitin-mediated immune signaling regulation","description":"Most terms point to ubiquitination and ubiquitin-dependent proteolysis (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, K6- and K48-linked ubiquitination, histone catabolic process) and to immune signaling pathways (adaptive immune response, TNF signaling, RIG-I signaling) with regulation of pathways such as JNK. This suggests a cohesive function in tagging and degrading proteins to modulate immune responses.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0051865","count":9},{"id":"GO:0046328","count":7},{"id":"GO:0085020","count":6},{"id":"GO:0070936","count":6}]},{"hash":"2251584420500700507","title":"Ubiquitin-Driven Protein Degradation","description":"The terms center on ubiquitin tagging and degradation, including ubiquitin-dependent ERAD, K48-linked and polyubiquitination, and general protein catabolic processes. Related items like Wnt receptor turnover and peroxisomal protein import suggest broader roles in protein quality control and regulated proteolysis. Overall, the cluster seems to represent components of the ubiquitin-proteasome system driving protein degradation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0046621","count":2},{"id":"GO:0070936","count":2},{"id":"GO:1900095","count":2},{"id":"GO:0016558","count":2}]},{"hash":"28697978056130107","title":"Broad signal transduction","description":"The proteins show GO terms spanning xenobiotic response, cardiac contraction regulation, serotonin metabolism, immune cytokine production, and retinal development, all pointing to diverse signaling and regulatory processes rather than a single pathway. The common theme is general signal transduction and stimulus response across tissues, so this broad label fits the cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":4},{"id":"GO:0086004","count":4},{"id":"GO:0019933","count":4},{"id":"GO:0046549","count":4},{"id":"GO:0006470","count":3}]},{"hash":"1710556130150170603","title":"Lipid and hormone biosynthesis with drug response","description":"GO terms cluster around lipid/hormone biosynthesis (mycolic acids, sphingolipids, PHB, testosterone, retinoic acid, tropane alkaloids) and drug/antibiotic response, indicating proteins linked to lipid/isoprenoid metabolism with xenobiotic stress responses.","confidence":"Medium","size":14,"edges":6,"triangles":1,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0046677","count":6},{"id":"GO:0042619","count":6},{"id":"GO:0031427","count":5},{"id":"GO:0030324","count":5}]},{"hash":"2261608752598797842","title":"Vertebrate Development and Stress Response","description":"The cluster is enriched for vertebrate-development terms (forebrain development, neural tube closure, multicellular organism development, skeletal system development) along with transcriptional and stress-related terms (DNA-templated transcription; apoptotic signaling in response to ER stress) and environmental response terms (cellular response to cadmium ion, defense response to Gram-positive bacterium), suggesting a cohesive group of proteins involved in vertebrate embryogenesis that is modulated by cellular stress and environmental cues.","confidence":"High","size":14,"edges":50,"triangles":72,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":14},{"id":"GO:0030900","count":13},{"id":"GO:0050830","count":13},{"id":"GO:0006349","count":13},{"id":"GO:0001403","count":13}]},{"hash":"1655040101722395595","title":"Embryonic neural and ectodermal development","description":"The top GO terms cluster around motor neuron differentiation, spinal cord motor neuron fate specification, and ectoderm formation, indicating neural/ectodermal developmental roles. Additional terms about cell-matrix adhesion and actin dynamics fit morphogenesis, while metabolic terms are less central. Overall, the cluster aligns with embryonic neural and ectodermal development rather than a single metabolic pathway.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0045329","count":3},{"id":"GO:0019417","count":3},{"id":"GO:0032458","count":3}]},{"hash":"2100718720231512616","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0000289","count":2},{"id":"GO:0002107","count":2}]},{"hash":"1890286983272155521","title":"Embryonic Morphogenesis and Placental Development","description":"These proteins cluster around embryonic development processes: palate roof formation, left-right patterning, placental/trophoblast lineage differentiation, cartilage morphogenesis, and EMT events in heart development. The recurring theme is embryonic morphogenesis and organ development, with a notable emphasis on placental and craniofacial lineages and transcriptional regulation during development.","confidence":"High","size":14,"edges":9,"triangles":3,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0060021","count":10},{"id":"GO:0006366","count":9},{"id":"GO:0060707","count":9},{"id":"GO:0060972","count":9}]},{"hash":"1183260358645723339","title":"Myogenesis and Growth Signaling","description":"This cluster is enriched for terms tied to muscle development and growth-regulating signaling: hippo signaling, myoblast fusion, and positive regulation of canonical Wnt signaling, along with negative regulation of cardiac muscle cell proliferation. The co-occurrence of these pathways suggests a theme around myogenesis and control of cell proliferation and survival during muscle formation, with broader apoptotic regulation terms supporting development and remodeling.","confidence":"High","size":14,"edges":75,"triangles":208,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060044","count":14},{"id":"GO:0035329","count":14},{"id":"GO:0007520","count":14},{"id":"GO:0034351","count":14},{"id":"GO:0090153","count":14}]},{"hash":"1509641105813594268","title":"Lipid remodeling and signaling","description":"The top GO terms cluster around lipid metabolism and membrane remodeling, including cardiolipin acyl-chain remodeling, phosphatidylcholine remodeling, ether lipid biosynthesis, triglyceride biosynthesis, and platelet activating factor biosynthesis, suggesting a core theme of lipid creation and membrane signaling. A few terms relate to immune regulation and development, which may reflect signaling roles of lipids in those processes, but the dominant pattern supports lipid remodeling as the cluster\u2019s main function.","confidence":"Medium","size":14,"edges":33,"triangles":30,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0070236","count":11},{"id":"GO:0006663","count":11},{"id":"GO:0035965","count":11},{"id":"GO:0036151","count":11},{"id":"GO:0019432","count":11}]},{"hash":"1761887302358777752","title":"Ubiquitin-Dependent Proteolysis and Cell Cycle Regulation","description":"The strongest terms point to the ubiquitin-proteasome system (ubiquitin-dependent protein catabolic process and protein polyubiquitination) and regulation of the cell cycle (DNA replication initiation, mitotic G1 checkpoint). The circadian rhythm term adds a temporal dimension to proteostasis, suggesting coordinated timing of degradation with cell-cycle control. Some peripheral terms reflect broader catabolic processes and microtubule dynamics but do not override the central ubiquitin-mediated degradation and cell-cycle theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0042752","count":8},{"id":"GO:0000209","count":6},{"id":"GO:1903378","count":5},{"id":"GO:0006516","count":5}]},{"hash":"623258465386746810","title":"Mitochondrial copper homeostasis and Complex IV assembly","description":"The cluster is dominated by GO terms for copper ion transport and intracellular copper homeostasis, plus mitochondrial-related processes such as respiratory chain complex IV assembly and cristae formation, along with redox homeostasis. This points to a cohesive theme around copper-dependent mitochondrial function and inner-membrane structure maintenance, despite a few outliers (photosynthesis, oocyte construction) that may reflect broader or cross-species annotations. Overall, the evidence supports a mitochondrial, copper-dependent respiratory role for this protein set.","confidence":"High","size":14,"edges":83,"triangles":278,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006878","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0008535","count":2},{"id":"GO:0007308","count":2},{"id":"GO:0006825","count":2}]},{"hash":"223591629683186706","title":"Organogenesis and Transcriptional Regulation","description":"The terms point to core transcriptional control (transcription by RNA Pol II and its negative regulation) coupled with broad developmental processes across several organs (retina/eye morphogenesis, pituitary and pancreas development, habenula, spinal cord oligodendrocyte fate, etc.). This pattern suggests a set of proteins that coordinate developmental programs and organogenesis via transcriptional regulation rather than a single tissue-specific function.","confidence":"High","size":14,"edges":87,"triangles":318,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0031018","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0060041","count":6},{"id":"GO:2000288","count":6}]},{"hash":"1310133595137990881","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043010","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0051573","count":3},{"id":"GO:0061146","count":2}]},{"hash":"1040424842010238498","title":"Immune differentiation and ubiquitin degradation","description":"The top GO terms cluster around immune system development and differentiation\u2014germinal center formation, positive regulation of dendritic cell and pro-T cell differentiation, regulation of memory T cell differentiation, and isotype switching\u2014with a strong signal for ubiquitin-dependent protein catabolic process. This points to a core function in immune cell development coupled with ubiquitin-mediated protein turnover. Some terms (distal tubule morphogenesis, skeletal muscle fiber development) are unrelated to immunity, suggesting either pleiotropy or broader developmental roles in the protein set. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0002467","count":7},{"id":"GO:2001200","count":7},{"id":"GO:1900477","count":7},{"id":"GO:0072156","count":7}]},{"hash":"1468110961329065363","title":"Dopamine GPCR signaling and inflammatory regulation","description":"This cluster centers on GO terms tied to dopamine receptor signaling and its regulation (GO:0007191, GO:0060160, GO:0007194), including adenylate cyclase activity modulation and cAMP-related signaling. It also includes terms linking prostaglandin response and inflammatory regulation (GO:0071380, GO:0050728) and appetite modulation (GO:0032100), suggesting a cohesive theme around dopaminergic signaling with inflammatory and metabolic outputs. A few terms on cell wall catabolism and growth are less connected and may reflect annotation noise, but the dominant signal points to dopamine GPCR signaling and its regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007191","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0050728","count":3},{"id":"GO:0032100","count":3}]},{"hash":"1634414263994399009","title":"Zinc Homeostasis and Antibacterial Defense","description":"The top GO terms include antibacterial defense responses to both Gram-positive and Gram-negative bacteria and antibacterial humoral response, alongside several zinc ion transport and homeostasis terms (import, detoxification, intracellular balance). This suggests a theme where proteins participate in innate immune defense in tandem with zinc regulation, a key cofactor in many immune enzymes; a secondary, less central term about tubulin deacetylation is present but does not define the cluster. ","confidence":"Medium","size":14,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0050829","count":2},{"id":"GO:0090043","count":2},{"id":"GO:0019731","count":2},{"id":"GO:0010312","count":1}]},{"hash":"743461252523701285","title":"Dopamine signaling and cortical interneuron migration","description":"The top GO terms point to dopaminergic signaling modulation (negative regulation of dopamine receptor signaling, dopamine transport, GPCR- and adenylate cyclase\u2013related pathways) and neuronal development processes (cerebral cortex GABAergic interneuron migration), with one item hinting at a learning-related neural function (visual learning). This suggests a cohesive theme around neural signaling and cortical interneuron development, despite one outlier term. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":11},{"id":"GO:0060160","count":10},{"id":"GO:0090075","count":10},{"id":"GO:0007194","count":10},{"id":"GO:0016998","count":10}]},{"hash":"195713563054122153","title":"GPCR-MAPK Signaling Regulators","description":"The cluster is enriched for terms that center on regulation of GTPase activity and the ERK/MAPK cascade, along with GPCR-mediated signaling that activates adenylate cyclase and modulates Rho pathways. This suggests a group of proteins that collectively modulate GPCR signaling and downstream MAPK/Rho pathways, with physiological implications for vascular tone and muscle relaxation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0070374","count":7},{"id":"GO:0010579","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0022900","count":7}]},{"hash":"826029352461641131","title":"Mechanosensory signaling and neural development","description":"The dominant terms cluster around responses to mechanical and temperature stimuli (mechanical stimulus, pain perception, thermoception) along with cerebellar granule cell differentiation, hinting at neural development. Additional terms on SNARE regulation and poly-ADP-ribosylation reflect vesicle signaling, while an angiogenesis-related term suggests broader developmental signaling. Overall, it points to mechanosensory signaling linked to neural development and growth.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":7},{"id":"GO:0050966","count":6},{"id":"GO:0035544","count":6},{"id":"GO:0050960","count":6},{"id":"GO:0021707","count":6}]},{"hash":"36756487005302563","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000462","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0070979","count":5},{"id":"GO:2001162","count":5},{"id":"GO:0042273","count":5}]},{"hash":"478200121567900543","title":"Embryonic development and placental differentiation","description":"The top GO terms cluster around embryogenesis and tissue differentiation, especially placental/trophoblast differentiation, left-right pattern formation, and EMT-related heart development. Additional terms cover cartilage, endocrine system, and pancreatic development, suggesting a broad developmental program across multiple lineages. The common theme is developmental differentiation during embryogenesis, with a focus on placental formation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0003198","count":3}]},{"hash":"2128929570601237319","title":"Cardiac mitochondrial signaling and contraction","description":"This cluster centers on mitochondrial processes (fission, calcium regulation within mitochondria) and cardiac muscle function (contraction and response to muscle activity), suggesting a theme of mitochondrial signaling supporting cardiac energy metabolism. Ubiquitination and NF-kB-related terms indicate broader protein regulation but are secondary to the mitochondrial\u2013muscle axis.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0006919","count":3},{"id":"GO:0042345","count":3}]},{"hash":"1019239906084160510","title":"Neural development and synaptic signaling","description":"The proteins are enriched for brain-related development terms (multicellular organism development, corpus callosum development) and neuronal signaling pathways (PI3K/AKT, ERK1/ERK2 cascade), along with synapse assembly. While an innate immune term appears, the dominant theme points to neural development and neuronal signaling functions.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0051092","count":6},{"id":"GO:0043491","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0070374","count":6}]},{"hash":"398509761064373651","title":"Heart and vascular development with cell migration","description":"The GO terms center on heart development and vascular formation (including labyrinthine layer vessels), supported by cell migration and muscle precursor processes (myoblast fusion) and related extracellular matrix signaling. This points to a cohesive developmental program coordinating heart/vascular formation and tissue movement, with some supporting signaling reinforcing regulatory processes.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0016477","count":6},{"id":"GO:0010765","count":6},{"id":"GO:0010763","count":5},{"id":"GO:0018107","count":5}]},{"hash":"890521150263355848","title":"Embryogenesis and organogenesis","description":"The top GO terms cluster around early development and tissue formation, including trophoblast differentiation, left/right patterning, placental and endocrine system development, and morphogenetic processes like cartilage and skeletal muscle formation as well as EMT during heart formation. This suggests a broad embryonic development/organogenesis program rather than a single tissue-specific function.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0003198","count":4}]},{"hash":"1846747775228386615","title":"Rho-Mediated Actin Remodeling","description":"The top terms cluster around regulation of Rho protein signal transduction and actin cytoskeleton organization, along with GTPase activation and receptor clustering, suggesting a coherent role in Rho-driven actin remodeling and associated membrane signaling processes.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0030036","count":6},{"id":"GO:0070433","count":6},{"id":"GO:0043113","count":5},{"id":"GO:0007268","count":5}]},{"hash":"1797749690110131510","title":"Actin Cytoskeleton and Cell Migration","description":"Top terms point to cytoskeletal organization and motility, including neutrophil chemotaxis, microspike and sarcomere organization, and spindle assembly, all driven by actin/microtubule dynamics. Inositol phosphate metabolism terms hint at signaling that regulates the cytoskeleton, while neural tube development also involves coordinated cell movement. A xenobiotic response term appears but does not define the core theme; overall, the cluster centers on actin-based cytoskeleton remodeling and cell migration.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0090286","count":2}]},{"hash":"1610786779389125778","title":"Innate immune recognition and bacterial degradation","description":"The cluster is dominated by GO terms related to phagocytosis recognition, defense response to bacteria, and catabolic processing of bacterial cell walls (peptidoglycan and other macromolecules), as well as C-type lectin receptor signaling, all pointing to host-pathogen interactions and bacterial component processing. A few terms (e.g., locomotory behavior, synaptic transmission regulation) appear peripheral and do not define the core theme, but the immune-bacteria signals are the strongest. ","confidence":"Medium","size":13,"edges":12,"triangles":2,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":3},{"id":"GO:0016998","count":3},{"id":"GO:0019076","count":3},{"id":"GO:0042742","count":3},{"id":"GO:0007626","count":3}]},{"hash":"3227130168025972","title":"Unknown","description":"The GO terms are spread across metabolism, vesicle trafficking, organelle biogenesis, pigment and extracellular matrix processes, development, and immune function, with no single dominant theme tying them together.","confidence":"","size":13,"edges":18,"triangles":5,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090324","count":5},{"id":"GO:0055091","count":5},{"id":"GO:1900242","count":5},{"id":"GO:0010628","count":5},{"id":"GO:0010796","count":5}]},{"hash":"1674458967328870985","title":"Nucleophagy and Proteostasis in Nuclear Dynamics","description":"This cluster is driven by autophagy-related terms focused on nuclear components (piecemeal microautophagy of the nucleus and macroautophagy) and proteasome-mediated degradation with ubiquitin regulation, complemented by cell cycle\u2013related nuclear dynamics (nuclear membrane reassembly, sister chromatid biorientation). The common theme is coordinated degradation and remodeling of nuclear material during cell cycle\u2013related processes, i.e., nucleophagy coupled with proteostasis. ","confidence":"High","size":13,"edges":43,"triangles":47,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0034727","count":3},{"id":"GO:0043161","count":3},{"id":"GO:0051726","count":2},{"id":"GO:0016236","count":2},{"id":"GO:0030437","count":2}]},{"hash":"1260421196700195760","title":"Antigen presentation and adaptive immune activation","description":"This cluster centers on antigen processing and presentation via MHC I/II, T cell costimulation, B cell receptor signaling, and phagocytosis, with related hypersensitivity regulation. Together these terms point to an immune activation program involving antigen presentation and adaptive lymphocyte responses, despite some auxiliary terms like receptor internalization and proteolysis supporting antigen processing.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0019886","count":2},{"id":"GO:0031295","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0001805","count":2}]},{"hash":"383103023473381843","title":"Embryogenesis and tissue differentiation","description":"The top GO terms point to developmental processes across multiple tissues (placenta, heart, cartilage, pancreas) including differentiation, pattern formation, and EMT, suggesting a theme of embryonic development and lineage specification. There are also regulatory processes (mRNA splicing, histone methylation) that commonly modulate gene expression during development, supporting a cohesive developmental cluster.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0003198","count":4}]},{"hash":"2275716842550308322","title":"Angiogenesis and vascular development","description":"The cluster is dominated by GO terms tied to angiogenesis, VEGF signaling, endothelial cell migration, sprouting angiogenesis, and coronary vessel morphogenesis, supported by receptor tyrosine kinase activation and cell-matrix adhesion. While immune-related terms appear, the strongest signal points to vascular development and angiogenic signaling pathways.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0048010","count":5},{"id":"GO:0043536","count":4}]},{"hash":"1422507120617513248","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":54,"triangles":115,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051259","count":4},{"id":"GO:0006626","count":4},{"id":"GO:0006458","count":4},{"id":"GO:0009408","count":4},{"id":"GO:1900035","count":4}]},{"hash":"566525600641686498","title":"Dopaminergic signaling and calcium regulation in neurons","description":"The top GO terms cluster around dopamine signaling (dopamine transport; negative regulation of dopamine receptor signaling; AC-inhibiting GPCR pathway) and calcium dynamics (release of sequestered calcium into cytosol), with supporting neuronal development context (cerebral cortex GABAergic interneuron migration). These together suggest a neurochemical theme centered on dopamine- and calcium-mediated neuronal signaling, despite one outlier term. Confidence: Medium","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":10},{"id":"GO:0060160","count":9},{"id":"GO:0090075","count":9},{"id":"GO:0007194","count":9},{"id":"GO:0016998","count":9}]},{"hash":"185451618537152449","title":"Post-transcriptional RNA processing and regulation","description":"Proteins in this cluster are linked to RNA-level control of gene expression, including regulatory ncRNA-mediated silencing, mRNA splicing (via spliceosome), mRNA modification and stabilization, and translation initiation factor complex assembly. Despite some obsolete terms, the common thread is post-transcriptional regulation of mRNA fate and translation.","confidence":"High","size":13,"edges":32,"triangles":41,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":6},{"id":"GO:1905663","count":5},{"id":"GO:0097010","count":5},{"id":"GO:0016556","count":5},{"id":"GO:0048026","count":5}]},{"hash":"155483259043399354","title":"B cell signaling and actin dynamics","description":"This cluster shows enrichment for B cell\u2013related processes (B cell receptor signaling, positive regulation of B cell proliferation, innate immune response) alongside actin-driven motility (actin polymerization-dependent motility, actin filament bundle assembly, cell migration), indicating a link between immune signaling and cytoskeletal remodeling that supports activation and movement, with additional hints of trafficking and polarity functions.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070358","count":2},{"id":"GO:0042997","count":2},{"id":"GO:0030890","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0045087","count":2}]},{"hash":"1899124092400610168","title":"Spliceosome and RNA Processing Machinery","description":"The top GO terms are dominated by spliceosome-related processes (spliceosomal complex assembly, mRNA splicing via spliceosome, snRNP assembly) and RNA maturation (tRNA processing, SSU-rRNA maturation, histone mRNA metabolism), indicating a cohesive RNA processing/splicing cluster. Some chromatin- and stress-related terms appear (pericentric heterochromatin formation, hair cycle, water deprivation) but they are secondary to the core RNA metabolism signal.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000245","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0042633","count":8},{"id":"GO:1990141","count":8},{"id":"GO:0008033","count":8}]},{"hash":"2263619884196600234","title":"Potassium Transport and Membrane Potential","description":"The top GO terms cluster around potassium ion import/export, intracellular potassium homeostasis, and stabilization of membrane potential, pointing to a cohesive theme of potassium handling and membrane excitability. Other terms like development or angiogenesis appear ancillary, likely reflecting broader roles of some members rather than redefining the cluster\u2019s core function.","confidence":"High","size":13,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1990573","count":5},{"id":"GO:0030007","count":5},{"id":"GO:0097623","count":5},{"id":"GO:0030322","count":5},{"id":"GO:0014068","count":5}]},{"hash":"404576586348533745","title":"Ribosome biogenesis and translation initiation","description":"This cluster is dominated by GO terms tied to translation initiation and ribosome assembly, including formation of the translation preinitiation complex, translation reinitiation, maturation of rRNA and ribosomal subunits, and biogenesis of the large subunit. A brain development term is present but peripheral; the core signal centers on protein-synthesis machinery and its regulation.","confidence":"High","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001731","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0043981","count":4},{"id":"GO:0006446","count":4},{"id":"GO:0075525","count":4}]},{"hash":"2202631617224674746","title":"Acetylation-Driven Amino Sugar and Polyamine Metabolism","description":"The top GO terms cluster around acetylation events (N-terminal propionylation; spermidine and spermine acetylation) and amino sugar metabolism (glucosamine, N-acetylglucosamine pathways) as well as related biosynthesis like mycothiol. While some terms like angiogenesis and sporulation seem outliers, the dominant pattern points to acetylation-controlled metabolic processes involving amino-sugar and polyamine pathways. This suggests a coherent functional theme centered on acetylation-related metabolism in the cluster.","confidence":"Medium","size":13,"edges":45,"triangles":76,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":8},{"id":"GO:0030435","count":7},{"id":"GO:0032918","count":7},{"id":"GO:0061606","count":7},{"id":"GO:0032919","count":7}]},{"hash":"1991588934128028070","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":12,"triangles":1,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":1},{"id":"GO:0000395","count":1},{"id":"GO:0006370","count":1},{"id":"GO:0036031","count":1},{"id":"GO:0032259","count":1}]},{"hash":"1591549031981762799","title":"Plant cell wall biosynthesis and glycosylation","description":"The top GO terms cluster around plant-specific cell wall biosynthesis (homogalacturonan, glucuronoxylan, mucilage; plant-type secondary cell wall biogenesis) and protein O-linked glycosylation, together suggesting these proteins function in polysaccharide assembly and glycosylation of cell wall components in plants.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016266","count":3},{"id":"GO:0035269","count":3},{"id":"GO:0009834","count":3},{"id":"GO:0071555","count":3},{"id":"GO:0010289","count":3}]},{"hash":"1218931972857507711","title":"Radial glia migration and actin-GTPase dynamics","description":"This cluster centers on actin cytoskeleton remodeling and GTPase signaling that drive cell movement and polarity in neural development. Terms like actin cytoskeleton organization, actin filament bundle assembly, small GTPase-mediated signaling, and extension of leading processes in cerebral cortex radial glia guide the interpretation toward cytoskeletal dynamics controlling neural migration and polarity establishment; long-term synaptic depression hints at a neuronal context but is not the dominant theme. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0090162","count":4}]},{"hash":"445553671115330734","title":"Neural development and brain regionalization","description":"Most terms point to neural development and brain patterning (nerve impulse transmission, dopaminergic neuron differentiation, cerebral cortex regionalization, ventral spinal cord interneuron specification). A minority of terms relate to germ cell processes and somitogenesis, indicating some mixed signals, but the dominant theme is neural development. Therefore, Neural development and brain regionalization is a representative label.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":1},{"id":"GO:0021521","count":1},{"id":"GO:0002176","count":1},{"id":"GO:1900114","count":1},{"id":"GO:0014807","count":1}]},{"hash":"1360478894350322690","title":"Neuronal development and synaptic plasticity","description":"The cluster is enriched for neural-related terms: long-term synaptic potentiation, axonogenesis, astrocyte differentiation, and multicellular development, plus cytoskeletal dynamics (actin crosslinking) and signaling regulation (GTPase activity, NF-kappaB). While there are some cardiac-related terms, the strongest signal centers on neural development and synaptic remodeling, with supporting cytoskeletal and signaling processes.","confidence":"High","size":13,"edges":8,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060291","count":9},{"id":"GO:0007507","count":7},{"id":"GO:0043547","count":6},{"id":"GO:0051764","count":6},{"id":"GO:0007409","count":6}]},{"hash":"449230148951398354","title":"Bacterial lipid and cofactor biosynthesis and metabolism","description":"This cluster centers on bacterial biosynthesis and metabolism of lipids, cofactors, and related metabolites (fatty acids, menaquinone, lipoteichoic acid, antibiotic biosynthesis) with some transcription background; the common thread is bacterial production of essential cellular components rather than a single pathway.","confidence":"Medium","size":13,"edges":61,"triangles":143,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:1902987","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0044539","count":3}]},{"hash":"1617978679743949522","title":"Growth factor signaling and cytoskeletal remodeling in development","description":"These terms converge on signaling pathways triggered by growth factors (VEGF, collagen-activated RTKs) that regulate cytoskeletal organization (cortical actin), cell migration (fibroblasts), and developmental processes (forebrain and cardiac muscle development, B cell differentiation). The common theme is growth-factor\u2013driven signaling coordinating cytoskeletal dynamics during development and tissue remodeling.","confidence":"High","size":13,"edges":64,"triangles":191,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":12},{"id":"GO:0035729","count":12},{"id":"GO:0002333","count":12},{"id":"GO:0006939","count":12},{"id":"GO:0030866","count":12}]},{"hash":"1737594265151784065","title":"Developmental signaling with cytoskeletal remodeling","description":"The top terms emphasize developmental processes (forebrain development, B cell differentiation, VEGF signaling, collagen receptor signaling) and cytoskeletal dynamics (actin organization, fibroblast migration, smooth muscle contraction), with accompanying cell cycle signals (DNA replication, mitotic cell cycle). Together they point to signaling pathways that drive development and tissue remodeling via cytoskeletal changes.","confidence":"Medium","size":13,"edges":5,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0000278","count":7},{"id":"GO:0030900","count":5},{"id":"GO:0035729","count":5},{"id":"GO:0002333","count":5}]},{"hash":"635931156799864177","title":"RNA Processing and Translation Machinery","description":"The top terms cluster around ribosome biogenesis (maturation of 5.8S rRNA), translation initiation (formation of translation preinitiation complex, translation reinitiation), and RNA processing (spliceosome-mediated splicing, mRNA polyadenylation). Together these indicate a shared role in RNA maturation and protein synthesis, with some developmental and signaling terms likely reflecting broader multifunctionality or annotation spillover. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000466","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0045292","count":4},{"id":"GO:0006378","count":4}]},{"hash":"1392244006266628335","title":"ERK/MAPK signaling and growth/differentiation processes","description":"Top terms indicate activation of MAPK/ERK signaling, regulation of GTPase activity, proliferation, differentiation, and angiogenesis, pointing to a core theme of signaling-driven growth and tissue remodeling. Some terms (photoreceptor maintenance, morphine response, neutrophil chemotaxis) are less central but may reflect broader signaling networks or dataset noise; overall the cluster appears tied to ERK/MAPK-mediated control of growth and angiogenesis.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0090023","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0045494","count":2}]},{"hash":"82386288673408782","title":"Developmental growth factor signaling and cytoskeletal remodeling","description":"This cluster centers on signaling pathways activated by growth factors (e.g., HGF, VEGF, collagen-activated RTKs) and concurrent changes in the actin cytoskeleton, along with cell migration and developmental processes such as forebrain and cardiac muscle development. The convergence of receptor signaling, JNK regulation, and cytoskeletal organization suggests a theme of signaling-driven development and cytoskeletal remodeling.","confidence":"Medium","size":13,"edges":66,"triangles":220,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":12},{"id":"GO:0035729","count":12},{"id":"GO:0002333","count":12},{"id":"GO:0006939","count":12},{"id":"GO:0030866","count":12}]},{"hash":"53104996453628592","title":"Endocrine gland development and metabolic signaling","description":"The top GO terms point to tissue- and gland-specific differentiation (mammary alveolus, Harderian gland, Leydig differentiation, ventricular cardiac muscle cell differentiation) along with regulation of insulin secretion and leptin response, suggesting hormone-regulated development and metabolic pathways; transcriptional control and xenobiotic metabolism further support a broad hormonal/metabolic regulatory theme.","confidence":"Medium","size":13,"edges":11,"triangles":10,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0060749","count":6},{"id":"GO:0033327","count":6},{"id":"GO:0050796","count":6},{"id":"GO:0044320","count":5}]},{"hash":"1179533865509612742","title":"Proteoglycan biosynthesis and sulfation","description":"The cluster is driven by GO terms tied to the production and modification of proteoglycans and glycosaminoglycans (especially heparan sulfate and chondroitin sulfate), including biosynthesis, enzymatic modification, and protein sulfation. These themes point to extracellular matrix components and their sulfation states as the core functional thread, with related sugar metabolism terms reinforcing this link. Some peripheral terms (e.g., xenobiotic metabolism, fat cell differentiation) may share enzymes or signaling pathways but do not override the central proteoglycan/sulfation theme.","confidence":"Medium","size":13,"edges":51,"triangles":90,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0015012","count":7},{"id":"GO:0006805","count":7},{"id":"GO:0030206","count":7},{"id":"GO:0048702","count":7},{"id":"GO:0042403","count":7}]},{"hash":"342637092313851562","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000472","count":5},{"id":"GO:0000480","count":5},{"id":"GO:0000447","count":5},{"id":"GO:0051028","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1421735231238416674","title":"Immune-Associated Endocytosis and Vesicle Trafficking","description":"The cluster is dominated by endocytosis and various vesicle-transport processes (ER-Golgi transport, Golgi inheritance, endosome-to-Golgi transport, anterograde synaptic vesicle transport, protein targeting to vacuole) and includes immune-related terms (response to virus, adaptive immune response, IL-1 response). This suggests a theme where vesicle trafficking supports immune signaling and responses.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:0009615","count":3},{"id":"GO:0071347","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0008344","count":2}]},{"hash":"1178947236914523392","title":"Unknown","description":"The GO terms are diverse, spanning innate immune response, heart development, B cell maturation, cytoskeletal/lamellipodium dynamics, Rho signaling, spermatogenesis, Golgi retention, and ion transport, with no single unifying function. The lack of coherent shared function and no edges among proteins prevent a meaningful, specific label.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0002344","count":3},{"id":"GO:0030032","count":3}]},{"hash":"1919134780080847124","title":"Rho GTPase\u2013driven cytoskeletal remodeling","description":"Enriched terms highlight regulation and assembly of filopodia, small GTPase\u2013mediated signaling, and Rho pathway control, plus positive regulation of cell spreading. This points to a common function in actin cytoskeleton remodeling and cell motility. Additional terms referring to GABAergic synaptic transmission and thrombin receptor signaling suggest broader signaling context, but the core shared function remains cytoskeletal dynamics driven by Rho GTPases.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051932","count":4},{"id":"GO:0051489","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0045725","count":4},{"id":"GO:0035621","count":4}]},{"hash":"1622662097803611750","title":"Mitochondrial Metabolite Transport and Insulin Response","description":"The cluster shows a convergence on transport of various metabolites across membranes (glycine, NAD, thiamine pyrophosphate, citrate, thiosulfate) and mitochondrial dynamics (membrane fission), along with GO terms tied to insulin/IGF signaling and adaptive thermogenesis. This points to a core function: coordinating mitochondrial substrate transport with energy regulation and insulin-responsive pathways.","confidence":"Medium","size":13,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0036233","count":3},{"id":"GO:0090149","count":3},{"id":"GO:0035352","count":3},{"id":"GO:0030974","count":3},{"id":"GO:1990845","count":3}]},{"hash":"1032536785605718761","title":"Dopamine GPCR signaling and receptor trafficking","description":"This cluster centers on G protein-coupled receptor signaling, with dopamine receptor pathway involvement, and processes of receptor endocytosis and trafficking (clathrin coat assembly, endosome-to-postsynaptic membrane transport, and receptor recycling), suggesting coordinated signaling and receptor trafficking at synapses.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0080028","count":2},{"id":"GO:0007212","count":1}]},{"hash":"2035260774554558481","title":"Post-transcriptional gene regulation in development","description":"The cluster\u2019s top GO terms cluster around RNA processing (spliceosomal snRNP assembly) and post-transcriptional control of gene expression (mRNA cap binding, translation initiation factor assembly, and miRNA-mediated silencing), plus regulation of processes like presynapse assembly and developmental events such as hair follicle maturation and spermatocyte division. This pattern points to a cohesive theme of post-transcriptional regulation during development, with some broader metabolic and signaling links.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":3},{"id":"GO:0006874","count":3},{"id":"GO:0048820","count":3},{"id":"GO:0010801","count":2},{"id":"GO:0048137","count":2}]},{"hash":"57891326464535948","title":"Embryonic Development and Organ Morphogenesis","description":"Predominant GO terms cluster around developmental processes across tissues, including endocrine system development, left-right pattern formation, cartilage morphogenesis, epithelial-to-mesenchymal transition in endocardial cushion formation, and placental/pancreatic cell development, pointing to a cohesive theme of embryogenesis and organogenesis. A few DNA repair terms appear but do not define the main function of the cluster. Overall, the label captures the central developmental/morphogenetic theme of the group.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060806","count":5}]},{"hash":"740276759867000852","title":"Vascular and hematopoietic development","description":"The strongest signals cluster around development of vascular and hematopoietic systems: lung development, blood vessel maturation, hematopoietic progenitor cell differentiation, and blood coagulation. Other terms (receptor clustering, spindle assembly, integrin biosynthesis regulation, metal ion response) likely reflect general cell signaling and adhesion processes engaged during organogenesis, but the dominant theme is vascular/hematopoietic development.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0061000","count":4},{"id":"GO:0051225","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0002244","count":3},{"id":"GO:0030324","count":3}]},{"hash":"1793958962823991858","title":"Neural sensory perception and dopaminergic signaling","description":"This cluster is dominated by GO terms tied to sensory perception (pain, vision) and neural signaling (dopaminergic synaptic transmission, ERK signaling, protein phosphorylation). The combination suggests proteins involved in processing sensory information and transducing signals through dopaminergic pathways, with broader stimulus responses (temperature, prostaglandin) and learning-related visual processes. Some terms like heart development may reflect pleiotropy or broad expression, but the core theme centers on neuronal sensory processing and signaling.","confidence":"Medium","size":13,"edges":18,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0071380","count":7},{"id":"GO:0007507","count":7}]},{"hash":"315661675754769201","title":"GPCR-cAMP Cardiovascular Signaling","description":"This cluster\u2019s GO terms largely point to GPCRs that activate adenylate cyclase and downstream cAMP signaling, including dopamine and prostaglandin pathways, as well as ERK cascade modulation and cardiovascular-related processes (blood pressure regulation, coagulation). While a few terms touch on metabolism, the dominant theme is GPCR-driven signaling that modulates cardiovascular function. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0010579","count":2},{"id":"GO:0045777","count":2}]},{"hash":"1886461044753758906","title":"Unknown","description":"The top GO terms span very different biological areas: bacterial cell wall/peptidoglycan catabolism, GPCR internalization and ERK signaling, retinal development and visual perception, photoreceptor maintenance, and even viral release. There is no single cohesive function uniting these terms, suggesting the cluster lacks a clear shared theme. ","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016998","count":8},{"id":"GO:0009253","count":8},{"id":"GO:0002031","count":8},{"id":"GO:0060041","count":8},{"id":"GO:0022400","count":8}]},{"hash":"1267512172092459314","title":"Chromatin Regulation and Developmental Signaling","description":"The top GO terms cluster around chromatin-level control (DNA-templated transcription; histone methylation), along with RNA processing (mRNA transport) and signaling pathways (TORC1 signaling; GTPase activity regulation; peptidyl-serine dephosphorylation). The presence of developmental processes (gastrulation; polar body extrusion during meiosis) and a note of mitophagy suggests a module linking transcriptional/chromatin regulation with growth, signaling, and developmental/quality-control processes. While the terms span multiple functions, they cohere around a chromatin-regulated transcriptional framework that interfaces with signaling and development, supporting this label as a representative description. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0034729","count":3},{"id":"GO:0051568","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1542475650781637181","title":"Neural development and stress-induced apoptosis","description":"This cluster prominently features GO terms for cerebral cortex and retina development, positive regulation of synaptic plasticity, and neuronal apoptotic processes, along with cellular responses to hypoxia and ER-stress-induced apoptotic signaling. The recurring theme centers on neural development with regulation of cell survival and death under stress, supported by ubiquitination-related regulation. Some terms about gonad and mammary gland involution are fellow tissues and make the signal noisier, but the neural development and stress-apoptosis axis is the most coherent core. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021987","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0051402","count":2}]},{"hash":"1360596954269105722","title":"Cardiac muscle contraction and sarcomere organization","description":"Most terms are about cardiac function and the contractile apparatus, including cardiac muscle contraction, sarcomere organization, regulation of heart rate, and regulation of sarcomere assembly. A few entries (spicule insertion, thermotaxis, membrane potential regulation) appear as outliers or cross-species annotations, but the dominant theme points to cardiac muscle machinery and its regulation. Confidence: High","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":13},{"id":"GO:0045214","count":13},{"id":"GO:1904753","count":13},{"id":"GO:1904706","count":13},{"id":"GO:0003065","count":13}]},{"hash":"1697527375919168097","title":"Neuro-Immune Signaling and Cell Migration","description":"Top GO terms point to immune activation, neural signaling, and vascular/chemotactic guidance, indicating a broad set of signaling pathways coordinating cell movement and activation across immune, neural, and endothelial contexts.","confidence":"Medium","size":12,"edges":55,"triangles":134,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":7},{"id":"GO:0010572","count":6},{"id":"GO:0019226","count":6},{"id":"GO:0038033","count":6},{"id":"GO:0060665","count":6}]},{"hash":"88955968337995898","title":"Developmental and Immune Signaling","description":"This cluster combines broad developmental processes (forebrain, thymus, cartilage condensation, metanephric kidney development) with immune-related activities (complement activation via lectin pathway, B cell differentiation, cellular response to fungal origin, platelet activation) and cytoskeletal remodeling (actin filament branching), suggesting proteins that coordinate organ development with immune signaling and structural changes rather than a single, cohesive pathway.","confidence":"Medium","size":12,"edges":22,"triangles":8,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0030900","count":7},{"id":"GO:0038063","count":7},{"id":"GO:0001502","count":6},{"id":"GO:0010572","count":6}]},{"hash":"1212123735355279907","title":"Embryonic organogenesis and muscle differentiation","description":"The top GO terms cluster around embryonic development events (diaphragm development, heart/vascular morphogenesis, S-shaped body morphogenesis) and muscle differentiation (negative regulation of myoblast proliferation, positive regulation of skeletal muscle cell differentiation). While some terms are broader (circadian gene regulation, response to drug), the dominant theme is organogenesis and muscle formation during embryogenesis, justifying a label centered on that process.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0048712","count":12},{"id":"GO:2001038","count":12},{"id":"GO:0003236","count":11},{"id":"GO:0003219","count":11},{"id":"GO:0070368","count":11}]},{"hash":"1052102575597958391","title":"GPCR-GTPase signaling with Rho/Ral regulation","description":"This cluster centers on GPCR signaling and small GTPase regulation (Rho and Ral pathways), with related receptor signaling (IGF, thrombin) and occasional cadmium response and apoptosis terms, suggesting a broad but GPCR-GTPase\u2013driven signaling theme.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":3},{"id":"GO:0090630","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0097194","count":3},{"id":"GO:0048009","count":2}]},{"hash":"2211950795707363397","title":"Innate Immune Signaling Regulators","description":"This cluster shows a concentration of terms tied to innate immune response, phagolysosome assembly, and regulation of signaling (including STAT phosphorylation and ubiquitination), plus membrane localization. While there are a few unrelated terms (bone mineralization, growth hormone signaling, paranodal junctions), the immune signaling focus dominates, suggesting these proteins collectively regulate innate immune pathways and intracellular trafficking. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0002315","count":3},{"id":"GO:0042518","count":3},{"id":"GO:0072659","count":3},{"id":"GO:0030500","count":3}]},{"hash":"1244535389469692175","title":"tRNA charging and translation machinery","description":"The top GO terms cluster around translation and multiple aminoacyl-tRNA synthetase activities (glycyl-, histidyl-, alanyl-, threonyl-, seryl-, and selenocysteinyl-tRNA synthetases), including both cytoplasmic and mitochondrial tRNA aminoacylation, plus related processes like mitochondrial tRNA charging and selenocysteine biosynthesis. This strongly points to a functional module focused on tRNA charging and the translation apparatus across cellular compartments.","confidence":"High","size":12,"edges":35,"triangles":48,"max_degree":11,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0002181","count":3},{"id":"GO:0016260","count":3},{"id":"GO:0070150","count":3},{"id":"GO:0006427","count":3}]},{"hash":"655191729164925596","title":"Embryonic morphogenesis and muscle development","description":"The cluster is enriched for embryonic development and tissue formation terms, including heart morphogenesis (sinus venosus morphogenesis, right ventricle formation), diaphragm development, and muscle differentiation/proliferation regulation, indicating a cohesive role in embryonic morphogenesis and muscle lineage specification. Some additional terms (circadian gene regulation, maternal processes) may reflect broader developmental regulatory programs that accompany embryogenesis, but the core signal centers on morphogenesis and muscle differentiation.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003236","count":12},{"id":"GO:0003219","count":12},{"id":"GO:0070368","count":12},{"id":"GO:0060137","count":12},{"id":"GO:0032922","count":12}]},{"hash":"415734313356410786","title":"Chemokine signaling and leukocyte chemotaxis","description":"The top terms center on chemokine-mediated signaling and chemotaxis of immune cells (monocytes, neutrophils, eosinophils), with related signaling pathways (GPCR-cAMP, calcium release, ERK cascade) that underpin leukocyte movement and inflammatory responses. This suggests a cohesive cluster focused on chemokine-driven immune cell trafficking.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":9},{"id":"GO:0051281","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0051930","count":9},{"id":"GO:0001975","count":9}]},{"hash":"2025485785398792224","title":"Lipoprotein Metabolism and Cholesterol Homeostasis","description":"It centers on lipoprotein processing and cholesterol balance, with strong signals for cholesterol efflux, HDL remodeling, triglyceride metabolism, and chylomicron clearance, pointing to a lipid transport/metabolic role; a peripheral term on Cdc42 signaling is less central.","confidence":"High","size":12,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033344","count":3},{"id":"GO:0034375","count":3},{"id":"GO:0019433","count":3},{"id":"GO:0070328","count":3},{"id":"GO:0042632","count":3}]},{"hash":"1251057897422787205","title":"Pollen exine formation and anther dehiscence","description":"The top terms are clearly tied to pollen development in plants, notably pollen exine formation and anther dehiscence, indicating a reproductive role. Supporting terms like protein N-linked glycosylation and protein homooligomerization align with secretory and cell-wall-related processes involved in pollen wall construction, while other metabolic terms may reflect general cellular activity. Overall, the cluster appears centered on pollen wall formation and release.","confidence":"High","size":12,"edges":59,"triangles":159,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0010584","count":5},{"id":"GO:0046032","count":5},{"id":"GO:0006256","count":5},{"id":"GO:0046706","count":5},{"id":"GO:0009901","count":5}]},{"hash":"896023310392001634","title":"Developmental Transcription & Chromatin Remodeling","description":"This cluster centers on transcriptional regulation and chromatin remodeling (negative regulation of transcription by RNA Pol II, DNA-templated transcription, chromatin remodeling) together with multiple embryonic morphogenesis processes (hindgut, pancreas, lens, ureteric bud). The combination suggests proteins that regulate gene expression through chromatin dynamics during organogenesis.","confidence":"High","size":12,"edges":21,"triangles":8,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:2001111","count":5},{"id":"GO:0043044","count":5},{"id":"GO:2001200","count":4},{"id":"GO:0048557","count":4}]},{"hash":"1678968277844880773","title":"DNA Damage Repair","description":"The top GO terms are dominated by DNA replication and DNA damage response functions (DNA replication, error-free translesion synthesis, UV-damage excision repair), indicating a genome-maintenance module. While there are ancillary terms related to Golgi trafficking and protein ubiquitination, the strongest signal centers on genome integrity processes, suggesting the cluster represents DNA replication/repair activities with possible secondary roles in cellular trafficking.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070987","count":4},{"id":"GO:0006260","count":4},{"id":"GO:2000158","count":3},{"id":"GO:0045053","count":3},{"id":"GO:0090261","count":3}]},{"hash":"1632618344284915466","title":"Nuclear mRNA Export and Ribosome Subunit Transport","description":"The GO terms are dominated by exports of ribosomal subunits and mRNA from the nucleus, plus related nuclear import/export and processing steps. This points to a coherent theme of nuclear RNA and ribosome trafficking, with ancillary regulation of transcription and centrosome-related processes that may reflect broader cell-cycle coordination. Therefore this label captures the core function of the cluster.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0034501","count":5},{"id":"GO:0010824","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0042176","count":5}]},{"hash":"2043946592944442344","title":"ER-Golgi vesicle transport and endosome routing","description":"The cluster is dominated by GO terms related to vesicle trafficking within the secretory and endosomal pathways, especially ER-to-Golgi transport, recycling/late endosome to Golgi transport, and plasma membrane to endosome transport, with positive regulation of ER-to-Golgi transport. While a few terms touch on transcription or fertilization, the strongest signal is intracellular trafficking between ER, Golgi, and endosomal compartments, suggesting a coherent trafficking-focused cluster.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0034599","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0009566","count":2},{"id":"GO:0071955","count":2}]},{"hash":"1715864096124540677","title":"Vision-related GPCR signaling and synaptic plasticity","description":"The cluster centers on GPCR signaling (GPCR internalization), vision-related pathways (opsin signaling, visual perception), and synaptic plasticity (long-term potentiation), suggesting a core theme of vision-linked neuronal signaling, with supporting regulatory processes like GTPase activity and apoptosis that can occur in various tissues.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0045953","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1727031719610015223","title":"Keratinization-enriched cluster","description":"The top GO term is keratinization (GO:0031424) with 7 proteins, indicating a skin/epithelial differentiation signal dominating the cluster. The remaining terms are diverse and sparsely represented, suggesting the other proteins contribute to unrelated processes or incidental associations. Thus, the cluster is best described as keratinization-enriched, with a medium level of confidence due to the mixed functional signals.","confidence":"Medium","size":12,"edges":28,"triangles":30,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":7},{"id":"GO:1902605","count":1},{"id":"GO:0007329","count":1},{"id":"GO:2000059","count":1},{"id":"GO:0008616","count":1}]},{"hash":"2200888697684031437","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006620","count":2},{"id":"GO:0051083","count":2},{"id":"GO:0090343","count":2},{"id":"GO:0048733","count":2},{"id":"GO:0035105","count":2}]},{"hash":"1068748091558557552","title":"Transmembrane transport of nutrients, ions, and xenobiotics","description":"The cluster is centered on diverse transmembrane transport activities (vitamins, sugars like galactose, xenobiotics, ions such as Na+/K+/phosphate, nitric processes, and even neurotransmitter loading into synaptic vesicles), suggesting a unifying role in membrane transport across substrates.","confidence":"High","size":12,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":5},{"id":"GO:0035461","count":5},{"id":"GO:0006855","count":5},{"id":"GO:0098700","count":4},{"id":"GO:0042128","count":4}]},{"hash":"1375192714912353654","title":"Inhibitors of BMP/Wnt/Activin signaling in development","description":"This cluster is enriched for GO terms that describe negative regulation of BMP, activin receptor, and canonical Wnt signaling, along with developmental processes such as CNS and heart development and cell adhesion. The convergence on signaling repression during embryogenesis, coupled with morphogenesis-related terms, suggests these proteins function as regulators that modulate key developmental signaling pathways and adhesion during organogenesis.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":3},{"id":"GO:0048147","count":2},{"id":"GO:0007417","count":2},{"id":"GO:0032926","count":2},{"id":"GO:0035414","count":2}]},{"hash":"1473566460770619738","title":"Ion transport and membrane potential regulation","description":"The cluster\u2019s top GO terms are dominated by transmembrane ion transport (potassium, calcium, chloride), calcium import, and membrane depolarization, with a connection to relaxation of cardiac muscle, pointing to ion transport and electrical signaling as the main theme. A few terms (metanephric development, ascospore formation, transcription factor sequestration) appear peripheral and may reflect broader or misannotated associations. Overall, the data support a cohesive label centered on ion transport and membrane potential regulation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072205","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0098703","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0051899","count":2}]},{"hash":"28646634206213981","title":"Cytoskeleton remodeling in motor neuron development","description":"The terms cluster around actin dynamics (actin filament depolymerization, endocytic recycling), cell-matrix adhesion, and neural development (motor neuron differentiation/specification), suggesting a theme of cytoskeletal remodeling guiding motor neuron morphogenesis.","confidence":"Medium","size":12,"edges":11,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0019417","count":12},{"id":"GO:0032458","count":12},{"id":"GO:0030042","count":12},{"id":"GO:0021526","count":12},{"id":"GO:0007160","count":12}]},{"hash":"390571679585429584","title":"Unknown","description":"The terms span diverse biological contexts (kidney development, fungal sporulation, neural/astrocyte differentiation, nuclear import, cardiac contraction, peripheral nerve myelination, calcium channel regulation, germ cell proliferation, NF-kappaB signaling, and muscle relaxation), with no single cohesive function tying the cluster together, so a specific label cannot be assigned.","confidence":"","size":12,"edges":26,"triangles":16,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0072221","count":8},{"id":"GO:0030437","count":6},{"id":"GO:0048708","count":6},{"id":"GO:0006607","count":6},{"id":"GO:0060048","count":6}]},{"hash":"1580915322975750474","title":"mRNA processing and translation initiation","description":"This cluster is dominated by GO terms for translation initiation and reinitiation (including preinitiation complex formation and regulation), alongside several mRNA maturation steps (export, modification, splicing, and polyadenylation). The combination suggests proteins that coordinate mRNA processing with translation initiation, possibly linking splicing/export-derived mRNPs to ribosome recruitment, with some viral translation context terms reflecting broader translation initiation mechanisms.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075522","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0006446","count":4},{"id":"GO:0075525","count":4},{"id":"GO:0001731","count":4}]},{"hash":"979423072047572061","title":"Neural signaling and drug-response","description":"The top GO terms coalesce around brain and nervous system functions: visual perception and learning; dopaminergic synaptic transmission; ERK signaling; and behavioral/physiological responses to psychoactive compounds like morphine and cocaine. These together point to neuronal signaling and drug-response pathways as the cluster\u2019s core. Some terms (e.g., heart development) are less aligned and may reflect pleiotropy, but the dominant theme remains neural communication and drug-associated behavior.","confidence":"Medium","size":12,"edges":5,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0071380","count":9},{"id":"GO:0008542","count":9},{"id":"GO:0001963","count":9}]},{"hash":"1196372323490717271","title":"Ubiquitin-Dependent NF-\u03baB Signaling and Apoptosis","description":"The cluster is dominated by ubiquitination-related processes (protein ubiquitination, ERAD, ubiquitin-dependent protein catabolic process) and inflammatory signaling (NF-\u03baB activation, I\u03baB phosphorylation, TNF signaling) with apoptosis regulation, suggesting proteins linked to ubiquitin-mediated degradation and modulation of NF-\u03baB\u2013driven survival pathways. A vitamin D response term appears, but the core theme centers on ubiquitin pathways and NF-\u03baB/apoptosis control.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033280","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0007250","count":5}]},{"hash":"1318214015569797985","title":"Homologous recombination and DNA repair","description":"The top GO terms point to homologous recombination\u2013mediated repair (SD-SDSA, reciprocal meiotic recombination, and heteroduplex formation) and telomere maintenance via recombination, indicating genome maintenance through HR. The inclusion of cellular responses to DNA-damaging agents (hydroxyurea, camptothecin, cisplatin) supports a DNA-damage response context, with a minor note of protein homooligomerization possibly reflecting repair complex formation. Overall, this cluster seems centered on HR-based DNA repair and genome stability under stress.","confidence":"High","size":12,"edges":44,"triangles":79,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006268","count":6},{"id":"GO:0045003","count":5},{"id":"GO:0007131","count":5},{"id":"GO:0000722","count":5},{"id":"GO:0030491","count":5}]},{"hash":"294550502238539432","title":"GPCR-cAMP signaling in vascular smooth muscle","description":"The top terms cluster around GPCR signaling that activates or modulates adenylate cyclase and cAMP pathways, including activation of adenylate cyclase, GPCR signaling, and related effects on blood pressure and smooth muscle relaxation. Some outliers (e.g., electron transport chain, cell wall catabolic processes) likely reflect broader annotations, but the core theme is GPCR-cAMP\u2013mediated regulation of vascular tone.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":7},{"id":"GO:0010579","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0051482","count":7}]},{"hash":"1646234534474882277","title":"Actin dynamics and mitotic processes","description":"The enriched GO terms cluster around actin cytoskeleton dynamics (actin filament depolymerization) and mitotic machinery (mitotic spindle assembly, contractile ring localization), with supporting roles in endocytic recycling and cell adhesion. Some terms (neural development, innate immunity, sulfur oxidation) appear as less cohesive outliers, but the dominant signal points to cytoskeletal remodeling linked to cell division and membrane trafficking.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0060733","count":2}]},{"hash":"675660013479023807","title":"Neural signaling and sensory perception","description":"This cluster centers on nervous system activity and sensory functions, reflected by terms for hearing, acetylcholine response, norepinephrine secretion, inhibitory postsynaptic potential, optic nerve development, and zinc ion response. While one term (acrosome reaction) is less related to neural signaling, the dominant GO terms point to neuronal communication and sensory processing, including visual and auditory pathways and neurotransmitter regulation. The presence of related terms such as amyloid fibril regulation also ties into neural context, supporting a neural/sensory theme overall.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:1905920","count":3},{"id":"GO:0002087","count":3},{"id":"GO:0007340","count":3},{"id":"GO:1905144","count":3}]},{"hash":"643812841784919767","title":"Golgi-ER Vesicle Trafficking Cluster","description":"This cluster is dominated by GO terms for vesicle transport within the secretory pathway, including ER-to-Golgi transport, intra-Golgi transport, retrograde endosome-to-Golgi trafficking, Golgi ribbon formation, and vesicle fusion with the Golgi, indicating a cohesive role in Golgi-ER trafficking; a few signaling terms are present but appear ancillary.","confidence":"High","size":12,"edges":55,"triangles":133,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0097192","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0042144","count":3},{"id":"GO:0090161","count":3}]},{"hash":"1927242551056286865","title":"Lipid remodeling and immune signaling","description":"The cluster is dominated by lipid biosynthetic and acyl-chain remodeling processes (cardiolipin, phosphatidylcholine, phosphatidylinositol, ether lipids) and triglyceride synthesis, indicating a core role in lipid metabolism. Immune-related terms (IL-2 production and negative regulation of T cell activation-induced cell death) suggest these lipid pathways intersect with immune regulation, with a few developmental terms that may reflect broader cellular contexts rather than a single function.","confidence":"Medium","size":12,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070236","count":2},{"id":"GO:0006663","count":2},{"id":"GO:0035965","count":2},{"id":"GO:0036151","count":2},{"id":"GO:0019432","count":2}]},{"hash":"627213899675737532","title":"Neural and glial development signaling","description":"This cluster centers on neural development and signaling, with GO terms for nerve impulse transmission, dendrite development, astrocyte differentiation, and BMP signaling, plus adhesion and migration-related processes that accompany neural morphogenesis. While some terms relate to broader development (notochord), the dominant theme is neural lineage specification and maturation via signaling pathways and cell\u2013substrate interactions.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0019226","count":9},{"id":"GO:1902955","count":9},{"id":"GO:0001954","count":9},{"id":"GO:0043491","count":9},{"id":"GO:0050773","count":9}]},{"hash":"1498744367112679236","title":"Immune Activation and Cytoskeleton Remodeling","description":"Dominant GO terms point to immune processes (B cell proliferation, response to lipopolysaccharide, phagocytosis, B cell receptor signaling regulation) and cytoskeletal dynamics (actin cytoskeleton and cytoskeleton organization, cell\u2013cell adhesion). These often co-occur in immune cell activation and in the cytoskeletal remodeling required for phagocytosis and immunological synapse formation. A few terms about GABAergic synaptic regulation are present but do not negate the core immune/cytoskeletal theme. Thus, the cluster is best described as immune activation with cytoskeletal remodeling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002322","count":3},{"id":"GO:0071222","count":2},{"id":"GO:0032228","count":2},{"id":"GO:0098609","count":2},{"id":"GO:0006909","count":2}]},{"hash":"77929196158955028","title":"Inflammasome-driven IL-1\u03b2 and IL-18 production","description":"The top GO terms point strongly to inflammasome biology, especially NLRP3 inflammasome assembly and IL-1\u03b2 and IL-18 production, along with interferon response and defense against protozoa\u2014hallmarks of innate inflammatory signaling. The accompanying terms about protein homooligomerization and ER membrane fusion can reflect assembly and trafficking processes underlying inflammasome activation. Together these suggest a cluster focused on inflammasome-mediated inflammatory cytokine production.","confidence":"High","size":12,"edges":15,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":7},{"id":"GO:0016320","count":6},{"id":"GO:0000002","count":4},{"id":"GO:0071346","count":4},{"id":"GO:1900227","count":4}]},{"hash":"219680536712606393","title":"Leukocyte migration and inflammatory signaling","description":"The cluster shows strong representation of immune/ inflammatory terms: leukocyte migration, neutrophil extravasation, TNF and IL-1 responses, and signaling pathways (NFAT, Notch) coupled with integrin-mediated adhesion, indicating coordinated leukocyte recruitment and inflammatory signaling. Some terms like keratinocyte differentiation or hormone responses appear peripheral, but the core theme is inflammatory leukocyte trafficking and signaling.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000391","count":4},{"id":"GO:0002523","count":4},{"id":"GO:0030216","count":4},{"id":"GO:0010042","count":4},{"id":"GO:0007220","count":4}]},{"hash":"2090971298967693800","title":"Ubiquitin-mediated NF-\u03baB signaling and apoptosis","description":"This cluster centers on ubiquitination-related processes (K63- and K6-linked ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination) and their link to NF-\u03baB pathway activation (both NFKB-inducing kinase activity and canonical NF-\u03baB signaling). The inclusion of TNF-mediated signaling and regulation of apoptotic processes supports a theme where ubiquitin signaling modulates NF-\u03baB activity and cell fate decisions. The histone catabolic term may reflect chromatin-related ubiquitination, while an obsolete potassium channel term likely represents annotation noise. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903265","count":8},{"id":"GO:0036205","count":8},{"id":"GO:0070534","count":8},{"id":"GO:0085020","count":8},{"id":"GO:0042787","count":8}]},{"hash":"715035323584737133","title":"Ubiquitin-Dependent NF-kappaB Immune Signaling","description":"Terms cluster around ubiquitin-dependent protein degradation and ubiquitination, with clear links to innate/adaptive immune responses, defense against viruses, and activation of NF-kappaB signaling. This suggests a cohesive role in regulating immune signaling via ubiquitin turnover and NF-kappaB pathways.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0030433","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":7},{"id":"GO:0051092","count":7}]},{"hash":"1549589997374065550","title":"Immune signaling and antigen presentation","description":"This cluster highlights both innate and adaptive immune processes (innate and adaptive immune response), regulation of antiviral signaling (negative regulation of RIG-I), antigen processing and presentation (MHC class I biosynthesis), and immunomodulatory factors such as vitamin D response and protein ubiquitination, with additional regulatory terms for transcription and apoptosis. Taken together, the dominant theme is immune signaling and antigen presentation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0032298","count":3},{"id":"GO:0007182","count":2},{"id":"GO:0039536","count":2}]},{"hash":"2066700147324605920","title":"Axon growth and guidance signaling","description":"The cluster is dominated by neuronal development terms: axonal fasciculation, axon extension (including regeneration), and axon extension involved in guidance, all pointing to axon growth and pathfinding. The presence of a cell surface receptor tyrosine kinase signaling pathway further supports RTK-mediated axon guidance and neuronal signaling. Some terms are obsolete, but the consistent theme is axon growth, guidance, and related signaling in neurons.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0007169","count":3},{"id":"GO:1903204","count":2},{"id":"GO:0048691","count":2}]},{"hash":"2076209011411567006","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":3},{"id":"GO:0006747","count":3},{"id":"GO:0046444","count":3},{"id":"GO:0009611","count":3},{"id":"GO:0019350","count":3}]},{"hash":"852286446372779784","title":"Unknown","description":"The terms span transcriptional regulation, stress/hormone responses, and various developmental processes, with no single cohesive function evident to tie the proteins together, so a specific label cannot be confidently assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903799","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0060136","count":2},{"id":"GO:1903936","count":2},{"id":"GO:0045600","count":2}]},{"hash":"1376112494821888883","title":"Neural signaling and retina development","description":"The top GO terms cluster around neuronal communication and eye development, including retina development, dopamine transport, GABAergic interneuron migration, and GPCR-related signaling that modulates adenylate cyclase activity, plus acetylcholine receptor signaling. A single odd term about cell wall catabolic processes likely reflects annotation noise or cross-species data, but the dominant theme ties neural signaling with retinal/brain development. This justifies a label focusing on neural signaling and retina development.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060041","count":12},{"id":"GO:0060160","count":11},{"id":"GO:0090075","count":11},{"id":"GO:0007194","count":11},{"id":"GO:0016998","count":11}]},{"hash":"374573652274389817","title":"Mitochondrial Metabolite Transport and Insulin Signaling","description":"The top terms point to transmembrane transport of metabolites (glycine, NAD, TPP, citrate) and mitochondrial dynamics (fission), alongside cellular responses to insulin/IGF stimuli and adaptive thermogenesis. This suggests a cohesive function around mitochondrial metabolism, energy homeostasis, and insulin signaling, despite one obsolete term appearing. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097274","count":3},{"id":"GO:0036233","count":2},{"id":"GO:0090149","count":2},{"id":"GO:0035352","count":2},{"id":"GO:0030974","count":2}]},{"hash":"1705969377778100003","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071039","count":4},{"id":"GO:0070481","count":3},{"id":"GO:0070478","count":3},{"id":"GO:0090502","count":3},{"id":"GO:0000467","count":3}]},{"hash":"2003762975942898825","title":"Embryogenesis and Reproductive Development","description":"This cluster shows enrichment for embryo-related processes: fertilization, embryonic pattern specification, in utero embryonic development, embryo implantation, and establishment or maintenance of cell polarity, suggesting a developmental/reproductive role in early embryo formation. A few terms (guanyine catabolic process, cytidine deamination editing, antibiotic response) seem unrelated and may reflect annotation noise or multifunctional proteins, but the dominant theme is embryogenesis. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045656","count":2},{"id":"GO:0009566","count":1},{"id":"GO:0009880","count":1},{"id":"GO:0035088","count":1},{"id":"GO:0007566","count":1}]},{"hash":"1049047631773620492","title":"Rac-mediated cytoskeleton remodeling and phagocytosis","description":"This cluster shows strong representation of Rac signaling, cytoskeleton organization, cell migration, and phagocytosis terms, pointing to a module of actin dynamics and engulfment. Some taste and development terms are present but likely peripheral noise; the core function is Rac-driven cytoskeletal remodeling and phagocytic activity.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050909","count":2},{"id":"GO:0001580","count":2},{"id":"GO:0006909","count":2},{"id":"GO:0006911","count":2},{"id":"GO:0007010","count":2}]},{"hash":"1529676199028553189","title":"Adaptive and Innate Immune Signaling","description":"This cluster shows strong enrichment for innate immune responses (innate immune response, interferon signaling, NK cytotoxicity) plus adaptive signaling (B and T cell receptor signaling, B cell affinity maturation) and phagocytosis recognition, indicating a module of activated immune cells coordinating defense.","confidence":"High","size":11,"edges":10,"triangles":3,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071226","count":8},{"id":"GO:0006968","count":7},{"id":"GO:0060337","count":7},{"id":"GO:0002344","count":7},{"id":"GO:0050853","count":7}]},{"hash":"859197723951732198","title":"Fungal Mating, DNA Replication, and Protein Quality Control","description":"Top GO terms point to nuclear processes (DNA replication, karyogamy) together with cell morphogenesis and protein folding/quality control (unfolded protein response, ER stress regulation, chaperone-assisted refolding). The inclusion of membrane targeting and fungal-specific cell wall biosynthesis supports a fungal developmental context focused on mating and cell-cycle progression, with emphasis on protein homeostasis and secretory pathway functions. ","confidence":"Medium","size":11,"edges":21,"triangles":13,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0000742","count":4},{"id":"GO:0070389","count":4},{"id":"GO:0000902","count":4},{"id":"GO:0046827","count":3}]},{"hash":"2087170613561483869","title":"Paranodal Axon Junction Proteins","description":"This cluster\u2019s top GO terms mainly describe localization to paranodal and juxtaparanodal regions of axons and the assembly of paranodal junctions, with supporting signals for plasma membrane localization and integrin-mediated signaling. Some terms (axis specification, B cell differentiation) seem incidental, but the dominant theme points to axon-domain organization and adhesion signaling at paranodes.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070986","count":5},{"id":"GO:0002315","count":5},{"id":"GO:0002175","count":5},{"id":"GO:0071205","count":5},{"id":"GO:0030913","count":5}]},{"hash":"273217126330451025","title":"TGF-\u03b2/SMAD developmental signaling","description":"This cluster is dominated by terms for transforming growth factor beta receptor signaling and SMAD-mediated transcription, with several entries linked to DNA-templated transcription and miRNA transcription regulation. The presence of cartilage development and gastrulation terms suggests TGF-\u03b2\u2013driven transcription programs active during development. Redox/oxygen-related terms appear but are less central to the core theme.","confidence":"High","size":11,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007179","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0007183","count":4},{"id":"GO:0032909","count":3},{"id":"GO:1902895","count":3}]},{"hash":"769371819734953642","title":"Cell Cycle and DNA Replication","description":"The top GO terms are dominated by mitosis- and DNA replication-related processes (G1/S transition, intra-S DNA damage checkpoint signaling, meiotic cell cycle, DNA replication, and kinetochore localization). A few terms pertain to neural development and signaling (Schwann cell development, excitatory postsynaptic potential, response to cocaine), suggesting some pleiotropy or context-specific roles. Overall, the cluster aligns best with a core cell cycle/DNA replication theme, with minor outliers.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031573","count":4},{"id":"GO:0014883","count":4},{"id":"GO:0051321","count":4},{"id":"GO:0034501","count":4},{"id":"GO:0051531","count":4}]},{"hash":"1885107055847766042","title":"Ubiquitin-regulated B cell signaling and lymphoid differentiation","description":"This cluster centers on ubiquitin-dependent proteolysis and autoubiquitination alongside B cell receptor signaling, germinal center formation, and dendritic/T cell differentiation, suggesting a theme of ubiquitin-regulated immune signaling and lymphoid development.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0050853","count":5},{"id":"GO:0046328","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0002467","count":4}]},{"hash":"471845952091055656","title":"Immune Signaling and Cytoskeletal Remodeling","description":"This cluster links immune signaling events (T cell activation via TCR-MHC, NK T cell differentiation, IL-2 production) with cytoskeletal remodeling (lamellipodium assembly, Rac/Rho signaling) and cell movement, including regulation of microglial migration. Hyaluronan metabolism and IGF signaling add extracellular matrix and growth signal context, suggesting coordinated signaling and actin dynamics in immune cells. Overall, the proteins appear to participate in immune activation together with cytoskeletal rearrangements.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0048009","count":6},{"id":"GO:0030212","count":6},{"id":"GO:0030032","count":6},{"id":"GO:0002291","count":6}]},{"hash":"2252653163382282501","title":"Innate Immunity and Angiogenesis Signaling","description":"This cluster centers on immune signaling, with terms like innate immune response and T cell receptor signaling, and also includes angiogenic signaling such as sprouting angiogenesis and ephrin receptor signaling. The presence of exosomal secretion regulation and calcium-dependent exocytosis suggests vesicle-mediated communication, possibly linking immune and vascular cells. The combination points to a coherent theme of immune signaling intertwined with angiogenesis and vesicle trafficking, rather than a single narrow function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0002040","count":3},{"id":"GO:1903542","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0033138","count":3}]},{"hash":"147552729535677250","title":"Cardiac development and cGMP signaling with ion transport","description":"The top terms cluster around heart-related development and function (outflow tract morphogenesis; regulation of heart rate by cardiac conduction) and cyclic nucleotide signaling (cellular responses to cAMP and cGMP) combined with ion transport (potassium and sodium transport). While a couple of terms are more general (aerotaxis, sensory perception of pain), the coherent emphasis on cardiac development and cyclic nucleotide signaling with ion movement supports a label focused on cardiac signaling and electrophysiology. ","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010754","count":7},{"id":"GO:0009454","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0098719","count":7},{"id":"GO:0019233","count":7}]},{"hash":"253156793314559209","title":"Vesicle trafficking and cell polarity regulation","description":"The top GO terms point to regulation of GTPase activity, vesicle transport (ER to Golgi), membrane tubulation, synaptic vesicle budding, and establishment of epithelial cell polarity, with additional links to actin/cytoskeletal remodeling (podosome assembly). This suggests a cohesive function in coordinating membrane trafficking and cytoskeletal dynamics to establish and maintain cellular polarity across different contexts, such as epithelial and neuronal cells, rather than a single narrow process.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:1902307","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0061000","count":3},{"id":"GO:1903527","count":3}]},{"hash":"1451021482131529824","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0000464","count":5},{"id":"GO:0000462","count":5},{"id":"GO:0042273","count":5}]},{"hash":"1956728735637131870","title":"mRNA Processing and Stability Regulation","description":"The cluster is dominated by GO terms related to post-transcriptional control: mRNA stability, modification, splicing via the spliceosome, splice site recognition, and translation initiation factor assembly. Together these indicate a cohesive theme of regulation of mRNA processing and stability, including responses to stress, rather than a single enzymatic activity.","confidence":"High","size":11,"edges":41,"triangles":74,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":11},{"id":"GO:1905663","count":7},{"id":"GO:0097010","count":7},{"id":"GO:0016556","count":7},{"id":"GO:0048026","count":7}]},{"hash":"250821843757433843","title":"Ribosomal Translation and Metabolic Processing","description":"The top GO term is translation (GO:0006412) with several proteins, indicating a core protein synthesis function. The presence of multiple metabolic and stress-related terms (gluconeogenesis, leucine catabolism, ketone body biosynthesis, fatty acid response, antibiotic response, DNA repair, steroid/dexamethasone response, sodium transport) suggests this cluster includes translation-related components connected to broader metabolic regulation and stress adaptation, rather than a single narrow pathway.","confidence":"Medium","size":11,"edges":31,"triangles":57,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0046677","count":3},{"id":"GO:0006094","count":3},{"id":"GO:0006552","count":3},{"id":"GO:0006814","count":3}]},{"hash":"728329856933235318","title":"Adhesion signaling and cytoskeletal remodeling","description":"Proteins in this cluster are enriched for cell\u2013matrix adhesion and signaling (integrin-mediated signaling, substrate adhesion-dependent cell spreading) and ECM-related processes (hyaluronan metabolic process, actin cytoskeleton reorganization). The presence of inflammatory signaling (interleukin-1 response) and RNA stress responses (stress granule assembly, mRNA decay) suggests ancillary regulatory layers, but the core theme centers on adhesion signaling and cytoskeletal remodeling with related ECM dynamics.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":3},{"id":"GO:0048240","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0030212","count":2},{"id":"GO:1905050","count":2}]},{"hash":"1817030601547474195","title":"Mitochondrial Translation and Protein Import","description":"This cluster is dominated by terms tied to mitochondrial energy metabolism and gene expression, including mitochondrial translation/translation initiation, ATP synthesis coupled electron transport, and protein import into the mitochondrial matrix and inner membrane. The chloroplast import term may reflect dual targeting or annotation noise, but the pattern centers on mitochondrial protein synthesis and targeting machinery, suggesting a cohesive mitochondria-associated functional group.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042775","count":2},{"id":"GO:0061179","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0070124","count":1},{"id":"GO:0032094","count":1}]},{"hash":"1715997225607932323","title":"Steroid and Hormone Biosynthesis and Metabolism","description":"The cluster is enriched for GO terms tied to biosynthesis and metabolic processing of steroids and hormones (testosterone, aldosterone, bile acids, prostaglandins, vitamin D response) and includes plant brassinosteroids, suggesting a core function in hormone-related biosynthesis/metabolism, with some related xenobiotic catabolism as supporting signals; overall a cohesive hormone/steroid metabolism theme.","confidence":"Medium","size":11,"edges":28,"triangles":28,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0019383","count":8},{"id":"GO:0001516","count":5},{"id":"GO:0033280","count":5},{"id":"GO:1900087","count":5},{"id":"GO:0010268","count":5}]},{"hash":"184173016850576305","title":"Neuronal calcium signaling and dopaminergic GPCR regulation","description":"This cluster is driven by GO terms tying calcium release into the cytosol, dopamine signaling and GPCR-regulated pathways (including adenylate cyclase inhibition), and dopamine transport, all of which point to neuronal signaling and calcium dynamics. Some terms are more general (growth, cell wall processes) but the strongest signals center on neuronal calcium activity and dopaminergic/GPCR regulation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":10},{"id":"GO:0060160","count":8},{"id":"GO:0090075","count":8},{"id":"GO:0007194","count":8},{"id":"GO:0016998","count":8}]},{"hash":"1137517331735654321","title":"Neural Development and GPCR Signaling","description":"The terms indicate neural differentiation, neuronal migration to the olfactory bulb, and synaptic modulation (GPCR signaling and regulation of postsynaptic potential), with ubiquitination also playing a role in neuronal regulation. Together they point to neural development and neuronal signaling as the core theme; a ribosomal export term is ancillary.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":4},{"id":"GO:0071260","count":3},{"id":"GO:0061101","count":3},{"id":"GO:0007186","count":2},{"id":"GO:0016567","count":2}]},{"hash":"2296871267085615879","title":"RNA processing and translation initiation","description":"The proteins are characterized by GO terms centered on mRNA splicing regulation, mRNA export, and mRNA modification, together with components and steps of translation initiation (preinitiation complex formation, translation reinitiation, and eIF4F complex assembly). This points to a cohesive theme of RNA processing and the start of protein synthesis, even though there are no observed edges in the cluster. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0006406","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0002188","count":7}]},{"hash":"1679141215880234747","title":"Neural development, vision, and behavior","description":"The cluster is dominated by brain-related terms: forebrain development, visual learning, visual perception, and behavioral responses (e.g., to cocaine), complemented by ERK1/2 signaling, which is a common neuronal pathway. There are a few outliers related to immune defense and cell-cycle regulation, but the strongest signal centers on neural development and sensory/behavioral processes, justifying a label focused on brain function and vision.","confidence":"Medium","size":11,"edges":25,"triangles":27,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045736","count":8},{"id":"GO:0034501","count":8},{"id":"GO:0030900","count":8},{"id":"GO:0050830","count":8},{"id":"GO:0008542","count":8}]},{"hash":"16416426330636081","title":"Protein acetylation and amino sugar metabolism","description":"The top GO terms point to multiple acetylation processes (spermidine/spermine acetylation, N-terminal protein/peptidyl-serine acetylation) alongside metabolic pathways for glucosamine and N-acetylglucosamine, and biosynthesis of arginine and mycothiol. This suggests a cohesive theme around acetylation-based regulation and amino-sugar metabolism, with one outlier term (angiogenesis) likely annotation noise. Confidence is aimed at capturing the shared functional thread, hence a Medium label.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0032918","count":4},{"id":"GO:0061606","count":4},{"id":"GO:0032919","count":4},{"id":"GO:0006041","count":4}]},{"hash":"536950755870749751","title":"Neural Development and Growth Factor Signaling","description":"The top GO terms point strongly to neural development processes, including cerebellar cortex formation, Bergmann glial differentiation, and forebrain development, as well as axon regeneration regulation, indicating a neural development-oriented cluster. Additionally, insulin signaling and growth factor\u2013related responses (insulin receptor signaling, glucose import regulation related to insulin, hepatocyte growth factor stimulus) suggest growth-factor\u2013mediated signaling relevant to neural contexts. Immune-related terms (T cell receptor signaling, transitional B cell differentiation) appear but are less central, possibly reflecting cross-talk or broader developmental signaling annotations. Overall, the dominant theme is neural development coupled with growth factor signaling. ","confidence":"Medium","size":11,"edges":10,"triangles":3,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050852","count":10},{"id":"GO:0021697","count":10},{"id":"GO:0048679","count":10},{"id":"GO:2001275","count":10},{"id":"GO:0060020","count":10}]},{"hash":"63708434574898877","title":"Ubiquitin-Dependent NF-kappaB/TNF Signaling","description":"The terms point to ubiquitin-dependent proteolysis and ubiquitination, with several connections to TNF-mediated signaling, NF-kappaB activation, and apoptosis regulation. This suggests a coherent cluster of proteins involved in ubiquitin-proteasome\u2013driven protein turnover and signaling pathways that control inflammatory responses and cell fate. Some GO terms are obsolete, but the core functions consistently align with ubiquitination processes and TNF/NF-kappaB signaling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0085020","count":5},{"id":"GO:0007250","count":5},{"id":"GO:1901253","count":5},{"id":"GO:2000620","count":5}]},{"hash":"1142146045092629899","title":"Golgi vesicle transport and SNARE-mediated exocytosis","description":"The cluster is dominated by GO terms for Golgi-related vesicle trafficking (ER-to-Golgi transport, intra-Golgi transport, Golgi ribbon formation, vesicle fusion with Golgi, and SNARE complex assembly) and Golgi-to-vacuole transport, plus terms tied to exocytosis and receptor trafficking (exocytic insertion of neurotransmitter receptors, protein localization to the cell surface) and synaptic potentiation. This points to a cohesive theme of Golgi- and secretory-pathway\u2013driven vesicle trafficking and membrane fusion events, including neuronal receptor trafficking and synaptic modulation.","confidence":"High","size":11,"edges":48,"triangles":112,"max_degree":10,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006888","count":9},{"id":"GO:0090161","count":9},{"id":"GO:0006891","count":9},{"id":"GO:0048280","count":9},{"id":"GO:0035493","count":8}]},{"hash":"1213044732170486601","title":"Lipid catabolism and membrane lipid remodeling","description":"The top GO terms cluster around lipid breakdown and turnover, including diacylglycerol, triglyceride, monoacylglycerol, phosphatidylserine catabolism, and fatty acid metabolism, as well as lipid signaling via the endocannabinoid pathway. Protein depalmitoylation links to lipid-protein modifications, reinforcing a lipid-centric functional theme. A few terms (e.g., cellulose catabolic process) may be noise, but the dominant signal supports lipid metabolism and membrane remodeling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046340","count":3},{"id":"GO:0042136","count":3},{"id":"GO:0030245","count":3},{"id":"GO:0042997","count":3},{"id":"GO:0006631","count":3}]},{"hash":"18455331280787221","title":"Wnt-driven development and cell cycle regulation","description":"The cluster shows enrichment in Wnt signaling-related terms (positive regulation of EMT and negative regulation of apoptosis via canonical Wnt), along with regulation of the cell cycle (including embryonic mitotic regulation) and broader developmental processes (root and superior colliculus development). Nuclear import and RNA Pol III transcription regulation appear as supporting cellular processes that can accompany developmental signaling. Overall, the proteins seem linked by signaling-driven development with an emphasis on Wnt-mediated control of growth and division.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":9},{"id":"GO:0086091","count":8},{"id":"GO:0044334","count":8},{"id":"GO:0006607","count":8},{"id":"GO:0015991","count":8}]},{"hash":"981970395417156604","title":"Unknown","description":"The top GO terms are diverse\u2014antibiotic response, thiamine biosynthesis, regulation of transcription, rRNA base methylation, glycerol catabolism, and other separate processes\u2014without any demonstrated connections or edges binding the proteins into a common pathway. Several terms are obsolete, suggesting noisy or mismatched annotations. Because there is no clear unifying function for the cluster, I label it Unknown.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0051572","count":2},{"id":"GO:0009228","count":2},{"id":"GO:0006355","count":2}]},{"hash":"559688662842605898","title":"Pyrimidine nucleotide salvage","description":"Most of the top GO terms in this cluster describe salvage pathways for nucleotides\u2014uracil salvage, CTP salvage, and UMP salvage\u2014pointing to a conserved function in recycling pyrimidine nucleotides. The other terms (regulation of mRNA binding, estrogen receptor signaling, inflammatory mediator production, etc.) are more diverse and likely represent ancillary or noise-related associations, but they do not override the clear salvage signal. Overall, this cluster appears enriched for pyrimidine nucleotide salvage activity.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0006223","count":2},{"id":"GO:0044211","count":2},{"id":"GO:0044206","count":2},{"id":"GO:0071639","count":2}]},{"hash":"440865921529312455","title":"Inflammation and stress-response signaling","description":"This cluster centers on immune/inflammatory signaling and stress-related pathways: GPCR signaling, PI3K/AKT, necroptosis, mast cell chemotaxis, and cellular responses to dexamethasone, along with antiviral/antibiotic response terms. Translation and myoblast fusion terms are present but appear less central, suggesting a cohesive theme of inflammatory and stress signaling with ancillary regulatory processes.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0045071","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0070266","count":2},{"id":"GO:0008344","count":2}]},{"hash":"1726364871283051021","title":"NMJ Development and ACh Receptor Clustering","description":"The GO terms center on neuromuscular junction development and acetylcholine-gated channel clustering, with regulation of neurotransmitter receptor activity supporting a theme of NMJ assembly and signaling. Other terms point to post-translational modifications and cytoskeletal regulation that can influence receptor localization, though a couple of terms appear less directly related. Overall, a cohesive interpretation is assembly and regulation of NMJ components at the muscle membrane.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007323","count":1},{"id":"GO:0007528","count":1},{"id":"GO:0051770","count":1},{"id":"GO:0090045","count":1},{"id":"GO:0090044","count":1}]},{"hash":"1113839641852917730","title":"Embryonic Organogenesis","description":"The top GO terms point to broad developmental and morphogenetic processes across multiple tissues (palate/tongue, cartilage, hair follicle, placenta, heart/EMT, endocrine development, pancreatic cells), indicating a shared focus on embryonic organ formation and tissue morphogenesis rather than a single tissue-specific function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":6},{"id":"GO:0060021","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0003198","count":6}]},{"hash":"794441583504587329","title":"Mechanosensory and stress-response signaling","description":"Top GO terms point to mechanosensation and pain-related responses (muscle stretch, detection of mechanical stimulus involved in sensory perception of pain, response to pain) and accompanying processes like cell migration, which are hallmarks of mechanotransduction and stress adaptation. Additional terms on fat cell differentiation, mRNA processing, and telomere regulation suggest a broader cellular stress/differentiation state rather than a single pathway, so the label best reflects the clustered functions without over-claiming a specific pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":4},{"id":"GO:0045444","count":4},{"id":"GO:1904355","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0006397","count":4}]},{"hash":"239037971257716267","title":"Embryonic neural and cardiac organogenesis","description":"The proteins are enriched for development-related GO terms spanning nervous system (midbrain development, neuron migration) and cardiac/organogenesis (heart development, pulmonary myocardium development, cranial skeleton morphogenesis, organ induction), pointing to a shared role in embryonic organogenesis with neural and cardiac emphasis. The presence of a general transcription regulation term fits as a broad regulatory layer in development.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0030901","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0048701","count":2}]},{"hash":"2123250763471774971","title":"Unknown","description":"The cluster's GO terms are highly heterogeneous (immune response, neural development, metabolism, and bacterial cell wall processes) with no dominant shared function, so a single cohesive label cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006955","count":2},{"id":"GO:0021692","count":2},{"id":"GO:0010795","count":2},{"id":"GO:1902171","count":2},{"id":"GO:1901006","count":2}]},{"hash":"2154796958172043850","title":"ER Protein Quality Control & Ubiquitination","description":"The cluster centers on ER-associated degradation, deubiquitination, deglycosylation, and ER stress response, indicating a cohesive role in ER proteostasis and ubiquitin-mediated protein quality control.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":5},{"id":"GO:1904378","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0034140","count":5},{"id":"GO:0097237","count":4}]},{"hash":"1810244030445116835","title":"Ubiquitin-Dependent Immune Signaling","description":"The cluster\u2019s top GO terms cluster around ubiquitin biology (deubiquitination and ubiquitin ligase activity) linked with immune and inflammatory signaling (TNF signaling, C-type lectin receptor signaling) and related processes such as viral infection, plus some stress responses. This points to a theme where ubiquitination dynamics modulate immune and inflammatory signaling pathways, rather than a single, narrow function.","confidence":"Medium","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":7},{"id":"GO:0061418","count":5},{"id":"GO:0002223","count":5},{"id":"GO:0010043","count":5},{"id":"GO:0006521","count":5}]},{"hash":"48778058594805718","title":"Embryonic organ morphogenesis and muscle differentiation","description":"These GO terms point to processes governing development and formation of organs\u2014heart structures (sinus venosus morphogenesis, cardiac right ventricle formation), diaphragm development, and nephron tubule morphogenesis\u2014along with muscle lineage differentiation (negative regulation of myoblast proliferation, positive regulation of skeletal muscle differentiation). The presence of broader regulatory terms (circadian regulation of gene expression, transcription regulation by glucose) suggests accompanying gene expression control during development. Together, they define a cluster of proteins involved in embryonic organ morphogenesis and muscle differentiation.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0003236","count":10},{"id":"GO:0003219","count":10},{"id":"GO:0070368","count":10},{"id":"GO:0032922","count":10},{"id":"GO:0072050","count":10}]},{"hash":"1442064799418090246","title":"Organogenesis and Tissue Development","description":"The top GO terms cluster around transcription by RNA polymerase II and diverse developmental processes across multiple tissues (bone differentiation, vascular healing, placenta and pancreas development, lactation) along with axis and immune signaling influences. This suggests a theme of transcriptional control guiding organogenesis and tissue differentiation in several contexts, justifying the label Organogenesis and Tissue Development.","confidence":"Medium","size":10,"edges":41,"triangles":94,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0045669","count":5},{"id":"GO:0035470","count":5},{"id":"GO:0071353","count":5},{"id":"GO:2000016","count":4}]},{"hash":"145290538086454164","title":"Embryonic axis formation and transcriptional control","description":"The GO terms cluster around developmental processes, especially left/right patterning/axis formation and embryonic development, along with transcriptional regulation (negative regulation of RNA polymerase II) and an associated epigenetic mark (H3K27 trimethylation). While some terms touch on sex-specific development, the dominant theme is embryonic development coupled with gene expression regulation, justifying a label focused on axis formation and transcriptional control.","confidence":"High","size":10,"edges":37,"triangles":70,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0035186","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0033092","count":4}]},{"hash":"1859433607140908002","title":"Drosophila Embryogenesis and Gonadal Morphogenesis","description":"The terms cluster around developmental processes from embryogenesis (gastrulation, embryonic development, ventral cord development) to organogenesis including eye morphogenesis and ovarian structures (germarium-derived germ-line cyst encapsulation, follicle cell stalk formation). Regulatory processes like transcriptional repression and ubiquitin-dependent proteolysis also tie into developmental regulation. Together, they suggest a cohesive theme of developmental morphogenesis and regulation in Drosophila.","confidence":"High","size":10,"edges":29,"triangles":35,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0033092","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0030708","count":3},{"id":"GO:0048593","count":3}]},{"hash":"2039042350443803906","title":"Embryonic craniofacial and cardiac organogenesis","description":"Top GO terms cluster around embryonic development, especially craniofacial structures (roof of mouth development, viscerocranium morphogenesis, trachea cartilage development) and heart formation (adult heart development, cardiac ventricle formation), with supporting skeletogenesis (osteoblast differentiation). Some terms point to early developmental events (primitive streak formation) and general transcription/chromatin maintenance (negative regulation of transcription by RNA polymerase II, CENP-A chromatin assembly), suggesting both developmental signaling and basic cell-cycle processes are represented. Overall, the cluster seems to reflect embryonic craniofacial and cardiac organogenesis.","confidence":"Medium","size":10,"edges":39,"triangles":81,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":7},{"id":"GO:0090009","count":6},{"id":"GO:0048703","count":6},{"id":"GO:0001649","count":6},{"id":"GO:0000122","count":5}]},{"hash":"1882769968899565820","title":"Translation and mRNA turnover","description":"The top GO terms are dominated by protein translation processes (initiation, elongation, termination, and overall translation) with additional signals for cytoplasmic translation and translational fidelity, plus a component of mRNA deadenylation-dependent decay. This pattern points to a cluster of proteins involved in the core translation machinery and related mRNA regulation, making the overall theme clearly centered on protein synthesis and mRNA turnover. Some peripheral terms (glial proliferation, antibiotic response) are less central but do not override the main translation-focused signal.","confidence":"High","size":10,"edges":37,"triangles":72,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0045901","count":4},{"id":"GO:0014009","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0006413","count":4}]},{"hash":"1035222002998009314","title":"Nuclear DNA Repair and Transcription Machinery","description":"The top GO terms cluster around nuclear DNA metabolism and transcription: nucleotide-excision repair, DNA replication-related steps, DNA topological changes, transcription initiation by RNA Pol II, and even RNA surveillance via nonsense-mediated decay, with a touch of UV protection. Although some terms are obsolete and one term reflects hair cell differentiation, the dominant theme is nuclear DNA maintenance and transcriptional regulation, suggesting a coherent functional group of DNA repair/replication and transcription machinery.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":5},{"id":"GO:0090305","count":4},{"id":"GO:0006289","count":4},{"id":"GO:0006268","count":4},{"id":"GO:0006367","count":4}]},{"hash":"1287584100464782102","title":"Rho/Rac GTPase signaling and actin assembly","description":"The proteins in this cluster are annotated primarily with GO terms related to Rho and Rac family GTPase signaling, and actin cytoskeleton dynamics such as lamellipodium and microspike assembly, along with neutrophil chemotaxis. This set shows a coherent theme of small GTPase\u2013mediated signal transduction driving actin remodeling and cell migration, even though the network edges are absent, suggesting these proteins function together in cytoskeletal reorganization during chemotaxis.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":5},{"id":"GO:0030035","count":4},{"id":"GO:0007266","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0030032","count":4}]},{"hash":"1344827763008573124","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":2,"triangles":0,"max_degree":1,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0072006","count":7},{"id":"GO:0035799","count":6},{"id":"GO:1904938","count":6},{"id":"GO:1903142","count":6}]},{"hash":"560766566074419029","title":"T cell activation and apoptosis signaling","description":"This cluster is driven by GO terms related to T cell receptor signaling (GO:0050852), T cell costimulation (GO:0031295), T cell apoptotic processes (GO:0070231), extrinsic apoptotic signaling (GO:0097192), execution phase of apoptosis (GO:0097194), and positive regulation of canonical NF-kappaB (GO:0043123). Together these indicate a core theme of T cell activation coupled with apoptosis regulation and NF-kappaB signaling. A few developmental terms (nervous system, heart, hippocampus development) appear among the top terms but are less representative of the cluster\u2019s main immune-apoptotic axis, likely reflecting broader roles or annotation overlap. Overall, the label emphasizes immune signaling with apoptosis control.","confidence":"Medium","size":10,"edges":34,"triangles":52,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043525","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0050852","count":3}]},{"hash":"382462017618036231","title":"Neuronal signaling and ion transport","description":"This cluster centers on neural communication and synaptic signaling, highlighted by locomotory behavior, GABAergic signaling, conditioned taste aversion, excitatory postsynaptic potential, and modulation of pain perception. It also includes sodium and potassium ion transport and negative regulation of adenylate cyclase, fitting a neural signaling and GPCR/ion channel theme. A couple of non-neural terms appear but do not change the overall interpretation.","confidence":"High","size":10,"edges":31,"triangles":41,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":9},{"id":"GO:0007214","count":9},{"id":"GO:0001661","count":9},{"id":"GO:0035725","count":7},{"id":"GO:0071805","count":6}]},{"hash":"2224720857081265259","title":"Plant-type cell wall biosynthesis and glycosylation","description":"The terms cluster around plant cell wall biosynthesis and modification, including plant-type secondary cell wall biogenesis, cell wall organization, and biosynthesis of homogalacturonan and glucuronoxylan, with additional indications of protein O-linked glycosylation; a few non-wall terms occur but with low frequency, likely representing noise.","confidence":"Medium","size":10,"edges":23,"triangles":23,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000709","count":2},{"id":"GO:0000722","count":2},{"id":"GO:0016266","count":2},{"id":"GO:0035269","count":2},{"id":"GO:0009834","count":2}]},{"hash":"2036046798984019450","title":"Negative regulation of growth and neural development","description":"The terms point to suppression of signaling and growth (negative regulation of cell proliferation, organ growth, ERK cascade, IL-6 production) with a neural development angle (neural plate morphogenesis), and a component of ubiquitin-mediated turnover via multivesicular body sorting that can downregulate signaling. This suggests a cohesive theme of growth/signaling repression in a developmental context, including neural development. ","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043162","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0010737","count":2},{"id":"GO:1900165","count":2},{"id":"GO:0070373","count":2}]},{"hash":"644710703521937589","title":"Neural energy metabolism and neurodevelopment","description":"This cluster mixes core metabolic processes (glycolysis, TCA cycle, pyruvate to acetyl-CoA regulation, glyoxylate metabolism) with neural development terms (cerebellar cortex, olfactory bulb mitral cell layer, pyramidal neuron development, neuronal migration), suggesting proteins that couple energy production to brain development and neuronal maturation. ","confidence":"Medium","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006096","count":6},{"id":"GO:0006099","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0021695","count":3},{"id":"GO:0061034","count":3}]},{"hash":"326256553263623642","title":"Unknown","description":"The terms span immune signaling (TLR4/8 pathways, inflammasome regulation) and unrelated development/morphogenesis processes, with no single cohesive function tying all proteins together. This mix suggests either heterogeneous annotations or cross-context multifunctionality, so a single coherent label isn\u2019t justifiable.","confidence":"","size":10,"edges":7,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006469","count":9},{"id":"GO:0070340","count":7},{"id":"GO:0007413","count":7},{"id":"GO:1900227","count":7},{"id":"GO:0070100","count":7}]},{"hash":"403348852587999479","title":"Ribosome biogenesis and chromatin assembly","description":"The set centers on ribosome biogenesis (ribosome, large subunit biogenesis), chromatin assembly (CENP-A\u2013containing chromatin assembly; histone H3-K36 dimethylation), and cell division, pointing to fundamental cell growth and chromosome maintenance processes. A couple of development terms (uterus/tarsal gland development) may be incidental or context-specific annotations and do not define the core theme. Thus the label reflects the cluster\u2019s primary functional theme in protein synthesis and genome organization.","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0061038","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000747","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0042254","count":2}]},{"hash":"35466290943664507","title":"Rap GTPase signaling and Golgi trafficking","description":"The cluster is dominated by GO terms for activation of GTPase activity and Rap protein signal transduction, indicating Rap-mediated signaling. Additional terms point to vesicle transport between ER and Golgi (recycling endosome to Golgi and ER-to-Golgi transport), suggesting a functional module in intracellular trafficking. While there are some transcription- and ribosome-related terms, the core theme centers on GTPase signaling linked to Golgi trafficking.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":3},{"id":"GO:0032486","count":3},{"id":"GO:0043966","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000462","count":2}]},{"hash":"1204272967006568806","title":"Unknown","description":"The top GO terms cover a broad, disparate set of biosynthetic processes (retinol/retinal, estrogen/androgen/glucocorticoid, mycolic acid, alkaloids, poly-hydroxybutyrate) and a drug response, with no single shared function or pathway linking the proteins. This lack of cohesive theme makes a precise label unreliable.","confidence":"","size":10,"edges":4,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0031427","count":6},{"id":"GO:0030324","count":6},{"id":"GO:0071768","count":6},{"id":"GO:0042572","count":6},{"id":"GO:0006703","count":6}]},{"hash":"803304417866161308","title":"Glucose-Driven Metabolic and Hemostatic Regulation","description":"This cluster centers on insulin processing and responses to glucose, alongside regulation of coagulation, fibrinolysis, bradykinin catabolism, and angiotensin levels. The combination suggests coordinated control of metabolic (glucose/insulin) and vascular/hemostatic (coagulation, blood pressure) processes, with liver regeneration as a related context. ","confidence":"High","size":10,"edges":13,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030070","count":5},{"id":"GO:0010757","count":4},{"id":"GO:2000346","count":4},{"id":"GO:0051918","count":4},{"id":"GO:0010815","count":4}]},{"hash":"2138927149490496633","title":"Gram-negative cell envelope biosynthesis","description":"This cluster is dominated by GO terms for lipid A biosynthesis, slime layer polysaccharide biosynthesis, and cell wall organization, indicating assembly of the bacterial outer envelope and surface polysaccharides. Other terms like ribosome biogenesis and response to antibiotic are more general, but the recurring theme is production of envelope components (lipids, sugars) and cell shape, suggesting a Gram-negative cell envelope biogenesis cluster.","confidence":"Medium","size":10,"edges":35,"triangles":58,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000902","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0009298","count":2},{"id":"GO:0005989","count":2}]},{"hash":"1728283444203413283","title":"Redox homeostasis and metabolic signaling in regeneration","description":"The cluster is dominated by oxidative stress-related terms (cellular oxidant detoxification, redox homeostasis) along with metabolic responses (response to starvation, xenobiotic catabolic process, prostaglandin biosynthetic process) and growth/regeneration processes (animal organ regeneration, regulation of growth, muscle calcium signaling). The presence of ERK pathway modulation and muscle contraction regulation suggests signaling cross-talk that coordinates redox state, metabolism, and tissue repair, making redox balance plus growth signaling a coherent, representative label.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":7},{"id":"GO:0045454","count":7},{"id":"GO:0001516","count":4},{"id":"GO:0031100","count":4},{"id":"GO:0070373","count":4}]},{"hash":"962740498651746648","title":"Septin-driven budding yeast polarity and cytokinesis","description":"This cluster is dominated by septin ring assembly, bud neck localization, division septum formation, and maintenance of cell polarity\u2014hallmarks of polarized growth and cytokinesis in budding yeast. Additional terms like cilium assembly and conjugation hint at related cytoskeletal organization and mating processes, supporting a core theme of septin- and polarity-guided cell division.","confidence":"High","size":10,"edges":18,"triangles":10,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:1902857","count":6},{"id":"GO:0097271","count":6},{"id":"GO:0030011","count":6},{"id":"GO:0000917","count":6},{"id":"GO:0000747","count":6}]},{"hash":"2019467523958895004","title":"Negative Regulation of Signaling Pathways","description":"Top terms are dominated by negative regulation across multiple signaling pathways (BMP, Wnt, PI3K/AKT, activin), with additional related developmental and proliferative processes. The cluster lacks a single unified pathway but consistently centers on inhibition of signaling and development, justifying this label as a representative, high-level theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":1},{"id":"GO:0048132","count":1},{"id":"GO:0007417","count":1},{"id":"GO:1905453","count":1},{"id":"GO:0007084","count":1}]},{"hash":"1366056063253317465","title":"Embryonic Organ Development","description":"Most of the top GO terms point to developmental processes across various tissues and stages, including embryonic development, organ morphogenesis (heart, pituitary, eye, gonads), and neural development (neuron maturation, Habenula). This suggests a theme of broad developmental programs shaping multiple organs during embryogenesis, so the label Embryonic Organ Development captures the cluster's core function.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0042551","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0007507","count":3}]},{"hash":"585814976909041752","title":"Microtubule dynamics and cell division","description":"This cluster is dominated by GO terms about microtubule nucleation, cytoskeletal organization, and mitotic processes (spindle pole duplication, cytokinesis, general cell division). While there are also neural development terms (neuron migration/differentiation) and mechanosensory references, the core signal centers on microtubule-based architecture and division, with neural terms likely representing downstream or context-specific roles.","confidence":"Medium","size":10,"edges":39,"triangles":78,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007020","count":9},{"id":"GO:1903087","count":9},{"id":"GO:0051301","count":6},{"id":"GO:0001764","count":5},{"id":"GO:0031122","count":5}]},{"hash":"1435059931657101107","title":"Retinoid, lipid, and sugar metabolism","description":"The top GO terms cluster around biosynthetic processes for retinol/retinal (vitamin A), bile acids and prostaglandins (lipid metabolism), and fructose/sorbitol biosynthesis (sugars), along with regulation of retinoic acid receptor signaling and oxidative stress response. This suggests a broad metabolic biosynthesis theme spanning vitamins, lipids, and carbohydrates, with some regulatory and physiological processes (e.g., pregnancy and kidney function) that are not defining of a single pathway. ","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":7},{"id":"GO:0042572","count":7},{"id":"GO:0001516","count":5},{"id":"GO:0060135","count":5},{"id":"GO:0003091","count":5}]},{"hash":"652313361907649527","title":"Innate antiviral immunity and ubiquitin-proteasome regulation","description":"The top GO terms show a cohesive theme of innate immune defense against viruses, paired with ubiquitin-dependent protein catabolism (including SCF and ERAD/proteasomal pathways). This points to a module where antiviral signaling is linked to regulated protein turnover, a common mechanism in antigen processing and immune regulation; ancillary terms like spleen development and NF-kappaB regulation fit within the broader immune-context cluster.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0051607","count":6},{"id":"GO:0048536","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":5}]},{"hash":"1510933165794930560","title":"Telomere maintenance and telomerase regulation","description":"Top GO terms are dominated by telomere-related processes: maintenance of telomeres via telomerase, telomere D-loop disassembly, and localization of proteins to telomeres, with positive regulation of telomere maintenance via telomerase. This points to a cluster enriched for telomere maintenance machinery and telomerase regulation. A few non-telomere terms appear in the list, but they are peripheral and do not define the cluster's core function.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061820","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0009395","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0021987","count":2}]},{"hash":"134724474315379263","title":"Mucosal innate immune defense","description":"Dominant GO terms describe innate immune responses at mucosal sites (GO:0002227), antibacterial humoral defense (GO:0019731), and defenses against Gram-positive bacteria (GO:0050830) and viruses (GO:0051607). These converge on mucosal innate immunity and antimicrobial defense, which justifies a concise label. A couple of terms relate to spermatogenesis and transcription regulation, which are outliers in this context but do not override the primary immune signal.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002227","count":2},{"id":"GO:0019731","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0008584","count":2}]},{"hash":"609622969590207954","title":"Regulation of cell growth and signaling","description":"The top GO terms point to broad regulatory processes: positive regulation of apoptotic and proliferation pathways, modulation of GTPase and kinase activities, protein autophosphorylation, and cell cycle control, with a hypoxia response. This suggests a cluster of proteins that modulate signaling and growth responses rather than a single enzymatic function, though some terms like mRNA transport hint at gene expression regulation under stress.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":4},{"id":"GO:0051028","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0071902","count":3},{"id":"GO:0008284","count":3}]},{"hash":"1659314416782844884","title":"Neural, Cardiac, and Vascular Development","description":"The top GO terms indicate coordinated programs of neural development (forebrain development, neural tube closure) alongside cardiovascular and vascular differentiation (vasculogenesis, ventricular cardiac muscle cell differentiation, myocardial precursor differentiation) and associated cytoskeletal remodeling (stress fiber assembly). The presence of cell cycle regulation terms aligns with differentiation-linked cell-cycle exit. Altogether, they point to developmental pathways shaping neural and heart/vascular tissues with related cytoskeletal changes.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0001570","count":3},{"id":"GO:0055012","count":3},{"id":"GO:1900239","count":3}]},{"hash":"1727769239173274661","title":"Endocytosis and membrane trafficking regulation","description":"Dominant GO terms center on endocytosis processes (ubiquitin-dependent and receptor-mediated) and on regulation of trafficking-related activities (GTPase activity). This points to control of vesicle formation and endocytic recycling, consistent with membrane trafficking and signaling. Some terms for visual perception and cell cycle appear as outliers but do not override the core endocytic/trafficking theme.","confidence":"Medium","size":10,"edges":36,"triangles":61,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033160","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0070086","count":5}]},{"hash":"565196183061366119","title":"Chromosome segregation and septin ring dynamics","description":"The top terms point to mitotic/meiosis-related chromosome dynamics (sister chromatid biorientation, centromeric cohesion, spindle orientation checkpoint, chromosome localization) and septin ring organization/disassembly, suggesting a cluster centered on cell division and cytoskeletal organization. Some terms (neurotrophin signaling, lipid kinase regulation) appear as noise but do not redefine the main theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051388","count":4},{"id":"GO:0031134","count":3},{"id":"GO:0090219","count":3},{"id":"GO:0032186","count":3},{"id":"GO:0031578","count":3}]},{"hash":"194527523965225542","title":"Neural synapse formation and plasticity","description":"The top GO terms cluster around nervous system connectivity and signaling: dendritic spine morphogenesis, synapse organization, neurotransmitter secretion, and long-term potentiation, all pointing to neural development and synaptic plasticity. While innate immunity terms appear, the dominant signal is synaptic formation and function, with glial-related regulatory processes likely reflecting neuroimmune interactions. This makes \"Neural synapse formation and plasticity\" a concise, intuitive label.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060997","count":7},{"id":"GO:0045087","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0050808","count":6},{"id":"GO:0007605","count":6}]},{"hash":"831232357500022314","title":"Rho/Rac GTPase Signaling in Development","description":"This cluster centers on terms for positive regulation of GTPase activity, especially Rho and Rac pathways, and connected signaling processes such as GPCR internalization and adrenergic receptor signaling in heart. It also includes developmental morphogenesis terms (imaginal leg morphogenesis, spinal cord development, pericardium morphogenesis) and neural myelination, suggesting a cohesive module where Rho-family GTPases coordinate signaling and morphogenesis in neural and cardiovascular contexts. The mitotic spindle assembly term is less central but may reflect broader cell-cycle\u2013linked regulation. Overall, the theme is Rho/Rac GTPase\u2013mediated signaling guiding development and tissue morphogenesis.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0090307","count":3},{"id":"GO:0035025","count":3},{"id":"GO:0007480","count":2},{"id":"GO:0022011","count":2}]},{"hash":"894027009950028608","title":"APC/C-Driven Ubiquitin Proteolysis in Cell Cycle","description":"This cluster is enriched for ubiquitin-dependent protein degradation terms, including ubiquitin-dependent proteolysis, K11-linked ubiquitination, and APC/C-dependent catabolic processes, along with mitotic cell cycle and anaphase-promoting complex\u2013regulated degradation. These together point to coordinated proteolysis governing cell cycle progression, making an APC/C-driven ubiquitin-proteasome theme the most representative label, despite a few miscellaneous terms.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0070979","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0030433","count":2}]},{"hash":"2235629392891968613","title":"Gram-positive cell wall biosynthesis","description":"The top terms cluster around peptidoglycan biosynthesis, lipoteichoic acid biosynthetic process, and cell wall organization, all classic features of Gram-positive bacterial cell-wall construction and maintenance (with a few plant metabolite annotations likely being misannotations or outliers). This supports labeling the cluster as related to Gram-positive cell wall biosynthesis.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0008360","count":9},{"id":"GO:0071555","count":9},{"id":"GO:0009252","count":9},{"id":"GO:0070980","count":8},{"id":"GO:0009718","count":8}]},{"hash":"1725653478580515545","title":"Embryonic Tissue Development and Morphogenesis","description":"This cluster\u2019s GO terms predominantly describe developmental processes across multiple tissues and organs (left/right pattern formation, placenta-related differentiation, endocrine system development, cartilage and skeletal muscle morphogenesis, and heart-associated EMT), pointing to a shared theme of embryogenesis and organ morphogenesis. A minor portion relates to immune differentiation, but the dominant signal is developmental patterning and tissue formation.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0060806","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060707","count":5}]},{"hash":"1035026910433377393","title":"Neural development and brain regionalization","description":"This cluster is driven by GO terms focused on neural development\u2014forebrain development, cerebral cortex regionalization, neuron differentiation and migration, and motor neuron differentiation\u2014indicating a cohesive theme of brain and spinal cord neurodevelopment. A few terms touch broader embryonic patterning and other lineages, but the strongest signal is neural patterning and brain formation, supporting the chosen label.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0001764","count":9},{"id":"GO:0061452","count":9},{"id":"GO:0060971","count":9},{"id":"GO:0003309","count":9}]},{"hash":"847219435208872460","title":"Astrocyte\u2013Endothelial Cytokine Signaling","description":"The cluster prominently features astrocyte differentiation and endothelial cell migration, along with cytokine production, peptide secretion, glucocorticoid response, and hypoxia-related signaling, suggesting cross-talk between astrocytes and vasculature under stress/inflammatory conditions, modulated at the transcriptional level. Although the terms span several related processes, they cohesively point to glial-vascular signaling and inflammatory regulation.","confidence":"Medium","size":10,"edges":20,"triangles":13,"max_degree":6,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0043388","count":7},{"id":"GO:0048708","count":7},{"id":"GO:0043542","count":7},{"id":"GO:0051384","count":7}]},{"hash":"2063705880939374388","title":"Cardiovascular and inflammatory signaling","description":"This cluster\u2019s terms point to vascular regulation and inflammation: regulation of blood pressure, positive regulation of blood coagulation, and angiotensin-activated signaling, plus IP-10 production and cell migration, suggesting a theme of vascular-immune signaling. A couple of terms (GPI anchor biosynthesis, oligodendrocyte differentiation) are less central and may reflect broader protein localization or peripheral roles, but the dominant pattern is cardiovascular/inflammatory signaling.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":2},{"id":"GO:0071660","count":1},{"id":"GO:0019677","count":1},{"id":"GO:0018120","count":1},{"id":"GO:0038166","count":1}]},{"hash":"2214305948898617749","title":"ECM remodeling and wound healing","description":"The cluster centers on extracellular matrix organization, cell-matrix adhesion, collagen fibril organization, and processes related to tissue repair and cell migration (notably keratinocyte movement and epidermal spreading). PKC signaling and FGF receptor signaling point to regulatory pathways that control these remodeling and healing processes, with a few outlier terms such as pancreas development and drinking behavior not altering the core theme.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043117","count":2},{"id":"GO:0045743","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0031016","count":2},{"id":"GO:0035988","count":2}]},{"hash":"2135411105539953230","title":"Developmental ECM Remodeling and Morphogenesis","description":"The top GO terms cluster around extracellular matrix organization, skin development, and morphogenetic processes (axis elongation, sprouting angiogenesis), suggesting a common theme of ECM-driven development and tissue morphogenesis. Ancillary terms like N-glycan processing and transcription regulation may reflect broader protein processing and gene expression activity in developing tissues.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0032516","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0007613","count":4},{"id":"GO:0030198","count":4},{"id":"GO:0045944","count":4}]},{"hash":"2241427317226451650","title":"Neuronal signaling and synaptic transmission","description":"The enriched GO terms point to neural communication: sodium and potassium ion transport, GABA signaling, response to acetylcholine, and excitatory postsynaptic potentials, plus behavior-related terms like locomotory behavior and conditioned taste aversion, indicating a cluster of proteins involved in synaptic transmission and neural-driven behaviors.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":9},{"id":"GO:0035725","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0007214","count":9},{"id":"GO:0060079","count":9}]},{"hash":"1358775597832959753","title":"Chemosensory taste and pheromone perception","description":"Dominant GO terms are about chemical-stimulus perception (including pheromone and taste detection), pointing to chemosensory receptors (olfactory/gustatory) that detect chemical cues and can influence behavior.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007606","count":4},{"id":"GO:0019236","count":4},{"id":"GO:0050909","count":2},{"id":"GO:0001580","count":2},{"id":"GO:0007626","count":2}]},{"hash":"223308240399058389","title":"Embryogenesis and organ morphogenesis","description":"The proteins in this cluster are enriched for diverse developmental processes including palate development, placenta-related differentiation, hair follicle morphogenesis, left-right patterning, mesoderm development, cartilage morphogenesis, and EMT in heart cushion formation, as well as endocrine system development. Together these GO terms point to embryonic tissue formation and organogenesis, suggesting a cohesive developmental/morphogenetic role for the cluster, despite no direct interaction edges observed. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0031069","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0007498","count":3}]},{"hash":"1001353397349286376","title":"Unknown","description":"The GO terms touch on spermatid development, neurogenesis, immune activation (complement), cytokine production, epithelial maintenance, muscle structure (sarcomere organization), and signaling regulation, showing a broad, scattered set of functions without a cohesive shared theme. Without a unifying process, a specific label isn\u2019t warranted.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:0001816","count":2},{"id":"GO:0030277","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0006958","count":2}]},{"hash":"1061315113975162493","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0097309","count":2}]},{"hash":"720022278449896046","title":"Phospholipid and sphingolipid metabolism","description":"The cluster is dominated by GO terms related to lipid metabolism, including phospholipid catabolic/dephosphorylation processes, phosphatidylglycerol biosynthesis, and sphingosine metabolism, indicating a lipid metabolism/signaling theme. Other terms such as glucose-6-phosphate transport and cellular oxidant detoxification appear less central, so the lipid-centric interpretation is the most representative. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009395","count":2},{"id":"GO:0044329","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0044330","count":2},{"id":"GO:0015760","count":2}]},{"hash":"1558045573103236142","title":"Epigenetic and ubiquitin-regulated development","description":"The cluster shows enrichment in ubiquitin-dependent protein turnover and ubiquitin-related signaling (e.g., K63-linked ubiquitination; regulation of ubiquitin-dependent protein catabolic process) alongside transcriptional and epigenetic control (RNA Pol II regulation, histone H3K4 trimethylation) and developmental processes (placental morphogenesis and stem cell maintenance), suggesting a cohesive module governing embryonic development through ubiquitin signaling and chromatin regulation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060669","count":5},{"id":"GO:0042787","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0080182","count":4},{"id":"GO:1902459","count":4}]},{"hash":"1916031229401006607","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042026","count":3},{"id":"GO:0031295","count":2},{"id":"GO:0014808","count":2},{"id":"GO:0007179","count":2},{"id":"GO:0022417","count":2}]},{"hash":"2219823930163354661","title":"Cilium formation and cytoskeletal development","description":"Proteins in this cluster are enriched for processes tied to building and remodeling microtubule-based structures (cilium assembly, spindle orientation, microtubule motor activity), intracellular trafficking (ER-to-Golgi transport), and developmental remodeling (wing morphogenesis, spermatogenesis) with accompanying autophagy and transcriptional regulation. The shared theme appears to be cytoskeletal organization and vesicular transport essential for development and cell division, hence the label.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1902857","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0007476","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0006914","count":2}]},{"hash":"567161364719880973","title":"Neural development and synaptic signaling","description":"Proteins in this cluster are enriched for neuron migration, locomotory behavior, and regulation of synaptic transmission, pointing to neural development and neural communication as core functions. Additional terms touch on organ regeneration, cell-matrix adhesion, and growth-factor\u2013related signaling (PDGF), plus immune-related processes, suggesting broader developmental signaling context while neural themes remain dominant.","confidence":"Medium","size":9,"edges":32,"triangles":60,"max_degree":8,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0001764","count":6},{"id":"GO:0030816","count":6},{"id":"GO:0008344","count":6},{"id":"GO:0031100","count":6},{"id":"GO:0001954","count":6}]},{"hash":"971016434616931929","title":"Ribosome biogenesis and stress-response DNA maintenance","description":"The top terms cluster around ribosomal small subunit assembly and translation, indicating active protein synthesis. Additional terms point to proteasomal degradation and cellular stress signaling (innate immune response, nitric oxide, cadmium) along with DNA replication and repair, suggesting a group of proteins coordinating translation with DNA maintenance under stress.","confidence":"Medium","size":9,"edges":13,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0000028","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006412","count":2}]},{"hash":"2073356985023898885","title":"DNA Repair and Proteostasis","description":"GO terms indicate core themes of protein quality control (ubiquitin-dependent proteolysis, proteasome assembly) alongside genome maintenance (transcription-coupled nucleotide-excision repair and DNA damage recognition). Additional signals point to gene-expression regulation and developmental contexts, suggesting a cluster centered on maintaining cellular integrity through proteostasis and DNA repair, with broader roles in differentiation. Confidence: Medium","confidence":"","size":9,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006511","count":2},{"id":"GO:0006283","count":2},{"id":"GO:0000266","count":2},{"id":"GO:0007275","count":1},{"id":"GO:0007127","count":1}]},{"hash":"2020036907708137250","title":"DNA replication, transcription, and cell cycle regulation","description":"The cluster centers on nuclear processes: DNA replication, transcription (DNA-templated), mRNA export, and meiotic/centromeric cohesion, all tying to cell division. While some terms touch on signaling, migration, and apoptosis (peripheral aspects of proliferation control), the core theme binds DNA synthesis/ transcription to chromosomal cohesion and division. Confidence: Medium","confidence":"","size":9,"edges":18,"triangles":13,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051754","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0006260","count":3}]},{"hash":"682265516710617747","title":"Central Carbon Metabolism","description":"This cluster is dominated by glycolysis and TCA-cycle terms (glycolytic process, tricarboxylic acid cycle, oxaloacetate/malate metabolism) plus related amino acid catabolism, pointing to core energy production and carbon flow. The xenobiotic and glucose response hints may reflect regulatory aspects, but the central theme is energy metabolism.","confidence":"High","size":9,"edges":26,"triangles":34,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0006107","count":5},{"id":"GO:0006096","count":5},{"id":"GO:0006099","count":5},{"id":"GO:0055114","count":5}]},{"hash":"1513395932536687899","title":"Vertebrate Development and Organogenesis","description":"The top GO terms are dominated by vertebrate developmental processes\u2014nervous system development, multicellular organism development, ossification, liver development, and outflow tract morphogenesis\u2014with additional cues to vascular/endothelial proliferation. While xenobiotic and immune responses appear as secondary terms, the strongest signal across the cluster points to development and organogenesis in vertebrates, justifying this label with a Medium confidence.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0010963","count":2}]},{"hash":"401333870348044289","title":"Translation Machinery and SRP-Mediated Targeting","description":"The cluster is dominated by terms for cytoplasmic translation and SRP-dependent cotranslational targeting to membranes, plus entries on translation fidelity and ER-associated stress responses, indicating a cohesive theme around the translation apparatus and membrane targeting of nascent proteins. A single outlier term for bacterial flagellum organization is present but does not override the main translation-centric signal.","confidence":"High","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0046677","count":3},{"id":"GO:0045903","count":2},{"id":"GO:1990145","count":2},{"id":"GO:0002181","count":1}]},{"hash":"1195112430087410944","title":"RNA pseudouridylation and translation machinery","description":"This cluster is enriched for RNA modification (pseudouridine synthesis) and global translation (including mitochondrial translation) terms, pointing to ribosome-associated RNA modification and protein synthesis. Protein oligomerization terms further support a ribosomal/translation complex theme, with a few outlier terms (BH4 biosynthesis, transcription, phenylalanine metabolism) that are less central.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000455","count":3},{"id":"GO:0031119","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0032543","count":2},{"id":"GO:0006729","count":1}]},{"hash":"527114410326815492","title":"Angiogenesis and vascular remodeling","description":"This cluster is dominated by terms related to blood vessel formation and signaling that drives sprouting angiogenesis (VEGF receptor pathway), coupled with cell migration and cell-matrix adhesion that support vascular remodeling. While there are additional themes like platelets, phagocytosis, and morphogenesis of heart-related structures, the strongest common thread is angiogenesis and vascular development.","confidence":"High","size":9,"edges":15,"triangles":6,"max_degree":7,"top_function":"wound healing","top_go_terms":[{"id":"GO:0048146","count":7},{"id":"GO:0070527","count":6},{"id":"GO:0030949","count":6},{"id":"GO:0050731","count":6},{"id":"GO:0006909","count":5}]},{"hash":"1244701233575430348","title":"Unknown","description":"The top GO terms show a mix of transport processes (ions/organic substrates) plus unrelated biology (sperm capacitation, sporulation, transcription regulation, gastric acid secretion), yielding no clear unifying function for the cluster.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":4},{"id":"GO:0031532","count":3},{"id":"GO:0019532","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0051454","count":2}]},{"hash":"2299416655306281859","title":"Neuronal signaling and synaptic plasticity","description":"The top GO terms are dominated by long-term synaptic potentiation, calcium channel activity regulation, and actin cytoskeleton remodeling, all core to synaptic function and plasticity. Additional terms point to neuronal differentiation and glial involvement (astrocyte differentiation), with supporting signaling pathways like GTPase regulation and NF-kappaB. While some terms reflect broader developmental programs, the strongest cluster signal centers on neuronal signaling and synaptic modulation, justifying this label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060291","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0051764","count":4},{"id":"GO:0048708","count":4}]},{"hash":"1612057841092573943","title":"RNA processing and translation regulation","description":"The dominant terms are mRNA processing and regulation of translation: polyadenylation, mRNA modification, splicing via spliceosome, mRNA stabilization, and eIF4F complex assembly, pointing to RNA maturation and translation control as the cluster's core function. The other terms (dendrite morphogenesis, erythrocyte differentiation, estrogen receptor signaling) are less central, possibly reflecting secondary regulatory or context-specific roles attaching to the same RNA- or signaling-associated proteins.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0048813","count":3},{"id":"GO:1905663","count":2},{"id":"GO:0097010","count":2},{"id":"GO:0030520","count":2}]},{"hash":"128633326566267911","title":"Neural development and axon guidance signaling","description":"This cluster centers on neural development and signaling: ephrin signaling, axon guidance/extension, calcium-dependent exocytosis, actin cytoskeleton dynamics, and pain perception, pointing to proteins involved in neuronal patterning and neurotransmitter release. The immune-related T cell receptor term is present but does not dominate the overall theme.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0048013","count":3},{"id":"GO:0033138","count":3},{"id":"GO:0045956","count":3}]},{"hash":"530275825685237706","title":"Neural development and axon guidance","description":"This cluster is dominated by nervous system\u2013related terms: nervous system development, positive regulation of synapse assembly, fasciculation of motor neuron axon, corpus callosum development, and hedgehog/ROBO signaling, pointing to brain wiring and synapse formation. A few terms (T cell receptor signaling, kidney development) may reflect broader multifunctional proteins or annotation cross-talk, but the central theme is neural development and axon guidance.","confidence":"Medium","size":9,"edges":14,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0022038","count":5},{"id":"GO:0071372","count":5}]},{"hash":"1518325997613060285","title":"Developmental Patterning","description":"GO terms point to broad developmental and morphogenetic roles across species\u2014segmentation, pattern specification, and tissue-specific development (root hair, intestinal epithelium, ovarian follicle cells, imaginal discs). While not tightly clustered around a single pathway, the common thread is developmental patterning and morphogenesis.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0018258","count":3},{"id":"GO:1902367","count":3},{"id":"GO:0036011","count":3},{"id":"GO:0007386","count":3},{"id":"GO:0032092","count":3}]},{"hash":"51959217374123471","title":"Dopaminergic and Cholinergic GPCR Signaling Regulation","description":"This cluster centers on GO terms that regulate GPCR signaling, especially dopaminergic and acetylcholinergic pathways. The prominence of dopamine receptor signaling regulation, dopamine transport, and adenylate cyclase activity points to modulation of cAMP signaling via GPCRs, complemented by autonomic outputs like saliva secretion and muscle relaxation that are driven by these pathways. The presence of neuronal development term (GABAergic interneuron migration) suggests a neural signaling context, supporting a coherent theme of neuromodulatory GPCR regulation.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":9},{"id":"GO:0060160","count":8},{"id":"GO:0090075","count":8},{"id":"GO:0007194","count":8},{"id":"GO:0016998","count":8}]},{"hash":"1630976503164995673","title":"Quinone biosynthesis and fatty-acid catabolism","description":"This cluster centers on lipid and amino-acid catabolism (fatty acid beta-oxidation, valine and phenylacetate catabolism) and the biosynthesis of quinones (menaquinone and phylloquinone), with an additional note of antibiotic biosynthesis suggesting bacterial secondary metabolism. These together point to energy-yielding metabolism linked to quinone synthesis, despite some peripheral terms like peroxisomal autophagy appearing. Overall, a coherent theme of lipid/amino-acid breakdown and quinone cofactor production. ","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":9},{"id":"GO:0010124","count":9},{"id":"GO:0006635","count":9},{"id":"GO:0017000","count":9},{"id":"GO:0009234","count":9}]},{"hash":"170836842527051051","title":"Developmental signaling and vesicle transport","description":"The cluster is dominated by developmental terms (skeletal, nervous, heart development), suggesting a role in development. It also includes Rho signaling, GTPase activity regulation, and protein heterotrimerization, pointing to coordinated cytoskeletal and signaling control, while an ER-to-Golgi vesicle transport term indicates active protein trafficking essential for morphogenesis. Overall, these functions imply developmental signaling coupled with intracellular transport and cytoskeletal regulation.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":9},{"id":"GO:0010255","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0007124","count":8}]},{"hash":"1235379937239751671","title":"Ciliary and flagellar motility with glycosylation","description":"This cluster is dominated by cilium/axoneme\u2013related processes (sperm axoneme assembly, flagellated sperm motility, epithelial cilium movement, and cilium movement regulation) and glycosylation-related terms (glycosphingolipid biosynthesis, lipid/galactosylation, and polyglycylation), suggesting a cohesive role in ciliary structure and surface modifications that support motility. The presence of a DNA repair term appears less connected, likely an outlier.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006688","count":2},{"id":"GO:0030259","count":2},{"id":"GO:0033580","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0006281","count":2}]},{"hash":"2028778497204174857","title":"Meiosis and DNA repair","description":"This cluster centers on meiotic processes, including reciprocal meiotic recombination, synaptonemal complex assembly, and female meiosis-specific sister chromatid cohesion, with links to ovarian follicle development. It also includes DNA damage response and repair activities (DSB repair via SDSA) and cellular responses to DNA-damaging agents, indicating a cohesive theme of meiosis paired with chromatin cohesion and repair.","confidence":"High","size":9,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007131","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0001541","count":2},{"id":"GO:0072711","count":1},{"id":"GO:0045003","count":1}]},{"hash":"919662606073009186","title":"Lymphocyte development and immune signaling","description":"Proteins in this cluster are enriched for T cell receptor signaling, B cell differentiation, and thymus development, indicating a primary role in lymphocyte development and adaptive immune signaling. Additional terms like innate immune response, cell migration, and ephrin receptor signaling point to coordinated immune cell movement and communication, with some terms related to trafficking and junction dynamics that can accompany immune activity. Overall, the dominant theme is immune system development and signaling in lymphocytes.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050852","count":9},{"id":"GO:0002333","count":8},{"id":"GO:0048538","count":8},{"id":"GO:2000251","count":8},{"id":"GO:0048013","count":8}]},{"hash":"578753626773535347","title":"ECM remodeling and angiogenesis regulation","description":"The cluster centers on extracellular matrix processes (collagen biosynthesis, proteoglycan catabolic process) and vascular development (endothelial tube morphogenesis, VEGF signaling), with BMP-responsive signaling and growth factor pathway modulation (HGF, VEGF) suggesting coordinated remodeling and angiogenic regulation during development and tissue remodeling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071773","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0001542","count":2},{"id":"GO:1902203","count":2},{"id":"GO:0032964","count":2}]},{"hash":"364026288331467212","title":"Unknown","description":"The top GO terms span immune signaling, neural synaptic transmission, development, and DNA transcription with no clear unifying function, suggesting a heterogeneous cluster. Because there isn\u2019t a coherent common theme tying the proteins together, a concise, representative label cannot be assigned with confidence.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097011","count":4},{"id":"GO:0000187","count":4},{"id":"GO:0000186","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0035249","count":4}]},{"hash":"1438894812858551724","title":"Neural development and signaling","description":"Based on the frequent GO terms, the cluster is enriched for nervous system\u2013related processes (myelination in peripheral nervous system, motor fiber type transitions, locomotion, response to cocaine, adenosine biosynthetic processes, and inflammatory regulation), suggesting a shared role in neural development and signaling. Some terms (ascospore formation, intra-S checkpoint) are less related and may be background noise, but the neural-related terms form a coherent thematic cluster.","confidence":"Medium","size":9,"edges":22,"triangles":16,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":3},{"id":"GO:0031573","count":2},{"id":"GO:0098609","count":2},{"id":"GO:0030437","count":2},{"id":"GO:0030324","count":2}]},{"hash":"1728603510745336834","title":"Neural Development Transcriptional Regulators","description":"The GO terms show a strong emphasis on DNA-templated transcription and neural development processes (forebrain development, neuron development, neural tube closure). This suggests the cluster represents transcriptional regulators coordinating neural development. Additional terms related to protein quality control, genomic imprinting, apoptosis under ER stress, and immune defense reflect broader regulatory connections, but do not override the central neural-development/transcription theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0046826","count":6},{"id":"GO:0030900","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0032435","count":6}]},{"hash":"238848623355262766","title":"Developmental and Neural Signaling","description":"This cluster combines GO terms for multicellular organism development, heart development, and angiogenesis with neural-related terms such as axonogenesis, long-term synaptic potentiation, excitatory postsynaptic potential, and visual perception, suggesting proteins here participate in broad developmental processes that also influence neural structure and function. The presence of mitotic cell cycle terms may reflect proliferative roles or background biology, but the dominant theme appears to be development intertwined with neural signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":7},{"id":"GO:0000086","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007409","count":6},{"id":"GO:0001525","count":6}]},{"hash":"295390038004400812","title":"Cell cycle and signaling regulators","description":"The top GO terms point to modulation of key signaling pathways (Wnt, insulin), phosphorylation events, and control of cell cycle transitions (G1/S and general regulation of the cell cycle). While some terms are more peripheral (lactation, transcription), the common thread is proteins involved in regulating cellular signaling and progression through the cell cycle. This supports labeling the cluster as regulators of cell cycle and signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":2},{"id":"GO:0060153","count":1},{"id":"GO:1905866","count":1},{"id":"GO:0046626","count":1},{"id":"GO:0060070","count":1}]},{"hash":"1781981093637146983","title":"TORC1 signaling and nuclear transport regulators","description":"The top GO terms cluster around TORC1 signaling, regulation of GTPase activity, and nuclear import/mRNA transport, suggesting proteins involved in intracellular signaling and trafficking to the nucleus; some developmental terms may reflect broader roles or annotation noise, but the core signal is TOR pathway regulation linked with nuclear transport.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0038202","count":3},{"id":"GO:0070262","count":3}]},{"hash":"1939106678823550927","title":"Signaling and Development","description":"Based on the top GO terms, the proteins cluster around signaling pathways (canonical NF-kappaB, ERK cascade, Rap signaling) and development-related processes, with additional terms touching cell cycle regulation and neuronal structure. This suggests a general role in signaling regulation during development, rather than a single specific pathway.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007249","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0032487","count":1},{"id":"GO:0009688","count":1}]},{"hash":"469041328389402533","title":"Hair follicle morphogenesis and actin cytoskeleton remodeling","description":"Contains terms tied to hair follicle morphogenesis, keratinization, and epidermal differentiation, with strong signals for actin cytoskeleton remodeling (lamellipodium assembly) and Rac-mediated signaling. This suggests the proteins function together in skin/hair development and cytoskeletal dynamics, including cell motility. Some terms are legacy/obsolete and outliers, but the core indicates skin differentiation and cytoskeletal regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0097284","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0031424","count":2}]},{"hash":"266807977417398944","title":"Neural and cardiac calcium signaling","description":"Most terms cluster around neural signaling and development (short-term memory, long-term synaptic potentiation, astrocyte differentiation, myelination) and cardiovascular function (regulation of heart rate, cardiac muscle contraction). The presence of store-operated calcium channel regulation and NLS-bearing protein import into the nucleus suggests calcium-dependent signaling linked to gene regulation, which can underpin both neural development and cardiac physiology. Some terms like ascospore formation and germ cell proliferation appear peripheral, possibly reflecting broader conserved signaling roles, but the strongest thread is calcium-dependent signaling in neural development and heart-related processes.","confidence":"Medium","size":9,"edges":29,"triangles":43,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007614","count":9},{"id":"GO:0060291","count":9},{"id":"GO:0002027","count":9},{"id":"GO:0030437","count":8},{"id":"GO:0048708","count":8}]},{"hash":"1587734941558098937","title":"Neuronal Synaptic Transmission and Mitochondrial Dynamics","description":"This cluster is dominated by neural communication terms\u2014learning, regulation of neurotransmitter secretion, synaptic vesicle exocytosis, neurotransmitter transport, glycine import, and synaptic plasticity\u2014together with mitochondrial membrane organization and fission. The co-occurrence suggests a functional module linking synaptic activity and mitochondrial dynamics, potentially reflecting coordinated energy supply and neurotransmission at synapses.","confidence":"High","size":9,"edges":16,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007612","count":3},{"id":"GO:0007006","count":2},{"id":"GO:0046928","count":2},{"id":"GO:0030073","count":2},{"id":"GO:0016079","count":2}]},{"hash":"1018569044218291961","title":"Germ cell development and chromatin remodeling","description":"The cluster centers on germ cell biology, with terms like spermatogenesis and male gonad development, suggesting a reproductive development theme. It is also strongly enriched for chromatin-related processes and transcription regulation (e.g., DNA replication-dependent chromatin assembly, transcription initiation-coupled chromatin remodeling, and negative regulation of transcription by RNA Pol II), indicating a link between chromatin architecture and gene expression during gametogenesis. Some terms such as vitellogenesis and cell migration appear, but the core signal points to germ cell development coordinated by chromatin remodeling and transcription control.","confidence":"Medium","size":9,"edges":27,"triangles":37,"max_degree":8,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0051290","count":6},{"id":"GO:0007283","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0071674","count":3}]},{"hash":"1072755104212943035","title":"GTPase-driven cell migration and epithelial polarity","description":"This cluster centers on small GTPase signaling and actin dynamics driving cell migration and the establishment/maintenance of epithelial cell polarity, as reflected by enrichment for GO terms like small GTPase-mediated signal transduction, actin filament bundle assembly, cell migration, and epithelial polarity establishment; additional terms such as EGFR signaling and branching morphogenesis similarly point to coordinated migratory/polarity programs, with innate immunity and mitotic cycle terms representing broader, less central contexts.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0060670","count":4}]},{"hash":"1428099995496452814","title":"Histone modification and transcription regulation","description":"This cluster is driven by GO terms for histone acetylation (H3/H4) and regulation of DNA-templated transcription, plus a deubiquitination process. These collectively point to a chromatin-regulatory module that modulates transcriptional activity, with a few developmental terms that are less central to the main signal. Overall, the cluster appears to represent chromatin modification coupled with transcription control.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0045652","count":3},{"id":"GO:0043981","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0043966","count":2}]},{"hash":"1481703529543140283","title":"Dopaminergic Neuron Development and Synaptic Regulation","description":"The top GO terms cluster around neuronal development and synaptic function, including dopaminergic neuron differentiation, presynaptic assembly regulation, synaptic vesicle endocytosis, and long-term synaptic plasticity, suggesting a cohesive theme of dopaminergic neuron development and synaptic regulation. Some terms are more general (e.g., vesicle fusion with the ER, responses to stimuli) but do not outweigh the neuronal-synaptic emphasis.","confidence":"Medium","size":9,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048279","count":1},{"id":"GO:1904715","count":1},{"id":"GO:0008344","count":1},{"id":"GO:0044344","count":1},{"id":"GO:0071542","count":1}]},{"hash":"1899796685206857056","title":"Unknown","description":"Top terms are diverse, spanning development, cell division, cell wall organization, metabolism, telomerase assembly, stress response, membrane permeability, secretion, sex differentiation, and muscle contraction. The lack of a unifying function and zero edges suggest these proteins do not form a coherent functional cluster, so a specific label cannot be assigned beyond Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009791","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0071555","count":2},{"id":"GO:0005978","count":2},{"id":"GO:1904884","count":2}]},{"hash":"1845091587631733243","title":"Inflammatory Angiogenesis and Leukocyte Recruitment","description":"The proteins here link endothelial/angiogenic signaling (VEGF receptor pathway, sprouting angiogenesis) with immune cell activities (neutrophil chemotaxis, mast cell degranulation, GM-CSF/IL-3 production, granzyme B production, NF-kB regulation, cell spreading), suggesting a coordinated inflammatory response that engages vascular remodeling and leukocyte recruitment/activation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002042","count":4},{"id":"GO:0045401","count":3},{"id":"GO:0034446","count":3},{"id":"GO:0030593","count":3},{"id":"GO:0045425","count":3}]},{"hash":"470422179520233053","title":"Hair Keratinization and Growth Cycle","description":"The top GO terms are keratinization and hair cycle, which together point to hair follicle biology and keratin production. The cluster likely groups proteins involved in epidermal keratinocyte differentiation and hair growth phases, making this label representative of the shared function.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":9},{"id":"GO:0042633","count":9}]},{"hash":"1676637355380741235","title":"Unknown","description":"The nine proteins show a scattered set of GO terms with little overlap, including defense/innate immune responses and various nuclear, replication, and membrane-related processes, each represented once. With no edges or a coherent shared function, there isn\u2019t a clear theme to label the cluster beyond Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0031665","count":1},{"id":"GO:0000054","count":1},{"id":"GO:0030174","count":1}]},{"hash":"1402140655331862084","title":"Vascular and hematopoietic development","description":"The cluster shows strong signals for vascular and hematopoietic development: blood vessel maturation, blood coagulation, hematopoietic progenitor differentiation, and lung development, plus regulation of BMP signaling, which aligns with developmental patterning and vascular/hematopoietic processes. Some terms like potassium ion transport, nitrate assimilation, and metal ion response appear less connected and may reflect annotation noise or broader cellular response terms, but the dominant themes point to vascular/hematopoietic functions and related signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0043113","count":2},{"id":"GO:0002244","count":2},{"id":"GO:0030324","count":2}]},{"hash":"1955589426417163574","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":5},{"id":"GO:0071375","count":4},{"id":"GO:0019395","count":4},{"id":"GO:0006695","count":4},{"id":"GO:0071372","count":4}]},{"hash":"1288889257970304343","title":"Unknown","description":"Top terms span development (BMP signaling), meiosis (chiasma assembly), DNA damage tolerance (translesion synthesis), immune signaling (C-type lectin receptor signaling, NF-kappaB), prolactin secretion, and ubiquitination (K48/K11). This wide mix provides no cohesive common function for the cluster, indicating a heterogeneous or noisy grouping rather than a single biological theme.","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043951","count":8},{"id":"GO:0030509","count":8},{"id":"GO:0051026","count":8},{"id":"GO:0042276","count":8},{"id":"GO:0002223","count":8}]},{"hash":"975915151707385445","title":"Unknown","description":"The top GO terms span DNA replication, transcription, ubiquitin-protease regulation, oxidative stress response, and ER-Golgi vesicle transport with protein retention, which reflect diverse, possibly independent cellular processes. There isn\u2019t a single coherent function tying these terms together, so a specific cluster label is not justifiable.","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0046827","count":5},{"id":"GO:2000158","count":3},{"id":"GO:0034599","count":3}]},{"hash":"966969527524460032","title":"Heterochromatin Formation and Transcription Regulation","description":"The dominant GO terms focus on chromatin state and epigenetic control: heterochromatin maintenance, DNA methylation\u2013dependent heterochromatin formation, rDNA heterochromatin formation, and regulation of nucleosome density, alongside DNA-templated transcription and deacetylation (peptidyl-lysine deacetylation). This pattern indicates a shared function in chromatin organization and transcriptional silencing, i.e., epigenetic regulation. A few terms about glycolytic regulation or cell migration appear secondary and not defining for the cluster.","confidence":"High","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0034983","count":6},{"id":"GO:0006344","count":6},{"id":"GO:0000183","count":6},{"id":"GO:0045820","count":6}]},{"hash":"1210950486867014162","title":"Embryonic organogenesis and morphogenesis","description":"This cluster centers on embryonic development across multiple tissues and organs (digestive tract, pancreas, skeletal system, neural crest), including branching morphogenesis (ureteric bud), and axis patterning (anterior/posterior). There's also regulatory activity affecting transcription and differentiation, which supports coordinated developmental programs. While some terms touch gamete development, the dominant theme is broad embryonic organ formation and tissue morphogenesis.","confidence":"High","size":8,"edges":6,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048557","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0090190","count":6},{"id":"GO:0031018","count":6},{"id":"GO:0001755","count":6}]},{"hash":"1381365540564605140","title":"Protein quality control under oxidative stress","description":"This cluster is dominated by GO terms related to maintaining protein integrity\u2014stabilization, repair, and modification\u2014and a concurrent response to oxidative stress, suggesting a module of protein quality control under oxidative conditions. Some auxiliary terms (e.g., Rap signaling, morphogenesis) are peripheral and less central to the core theme.","confidence":"High","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0050821","count":4},{"id":"GO:0006979","count":4},{"id":"GO:0030091","count":4},{"id":"GO:0006464","count":4},{"id":"GO:0055114","count":4}]},{"hash":"1656011359829547428","title":"Cardiac electrophysiology and atrial conduction","description":"The cluster's top GO terms cluster around heart rhythm and electrical activity: regulation of heart rate by cardiac conduction, atrial and AV node action potentials, membrane depolarization, and calcium ion transport via high-voltage-gated calcium channels. These collectively point to cardiac electrophysiology and atrial conduction as the core theme. Some terms related to pain perception and thermogenesis appear but are less representative of the cluster\u2019s main function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0002024","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0003151","count":6}]},{"hash":"1571550072697270028","title":"Postsynaptic density and synaptic signaling","description":"The terms converge on postsynaptic organization and signaling: AMPA receptor clustering, postsynaptic density assembly, GKAP clustering, ephrin receptor signaling, and synaptic plasticity such as long-term depression, all pointing to neuronal synapse function and modulation. Some terms (behavioral and immune signaling) are less central but don\u2019t override the main synaptic theme. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097113","count":2},{"id":"GO:0097117","count":2},{"id":"GO:0031666","count":2},{"id":"GO:0035176","count":2},{"id":"GO:2000822","count":2}]},{"hash":"1898134735940578087","title":"Neural development and axonogenesis","description":"The terms cluster around neural development and differentiation: neural tube patterning via Hedgehog signaling, Schwann cell development, axonogenesis, and visual system development, with some cell-cycle terms reflecting proliferating neural progenitors. Overall, a neural-specific developmental theme is most consistent with the data.","confidence":"High","size":8,"edges":11,"triangles":6,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":6},{"id":"GO:0001707","count":5},{"id":"GO:1901621","count":5},{"id":"GO:0071374","count":5},{"id":"GO:0006260","count":5}]},{"hash":"736629344014024537","title":"Rac-Driven Cytoskeleton Remodeling and Migration","description":"The top GO terms point to small GTPase signaling (Rac), actin cytoskeleton dynamics, and motifs of cell movement, including lamellipodium and filopodium assembly, cell migration, and cell spreading. While terms like NK T cell differentiation and B cell maturation reflect immune context, the dominant signals are Rac-mediated actin remodeling and motility, suggesting a cluster of proteins that coordinate cytoskeletal changes to drive cell movement in development and immune settings.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0035020","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0007264","count":5},{"id":"GO:0001865","count":5}]},{"hash":"360794998959135664","title":"Ribosome Biogenesis & Translation","description":"The cluster is dominated by translation and ribosome assembly terms (GO:0006412, GO:0000028, GO:0000027), pointing to proteins involved in ribosome construction and protein synthesis. The remaining terms are less represented, suggesting secondary associations rather than a distinct, separate process.","confidence":"High","size":8,"edges":15,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000028","count":3},{"id":"GO:0002548","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0006407","count":2}]},{"hash":"1929226250347284121","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0006506","count":2},{"id":"GO:0032094","count":1},{"id":"GO:0007286","count":1},{"id":"GO:0018406","count":1}]},{"hash":"1875406156786341178","title":"Unknown","description":"The top GO terms span telomere/telomerase localization, cell cycle, stress responses (heat, ischemia), virion assembly, and even a reproductive binding term, with several obsolete annotations. This broad mix lacks a single, coherent biological function to bind the cluster, so a specific label isn\u2019t justifiable. Confidence: None","confidence":"","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1904851","count":8},{"id":"GO:1904874","count":8},{"id":"GO:0002931","count":8},{"id":"GO:1901998","count":8},{"id":"GO:0051973","count":8}]},{"hash":"1293448762616434193","title":"Podosome and Filopodium Assembly with Integrin Signaling","description":"The cluster is dominated by GO terms for actin-based protrusions and cytoskeleton remodeling (podosome/filopodium/actin filament bundle assembly) plus integrin-mediated signaling, indicating a cohesive set of proteins involved in cell adhesion and dynamic protrusion. Additional terms on centrosome localization and synaptic structural plasticity support a broader role in cytoskeletal organization and adhesion-related signaling, making the overall theme clearly centered on actin-driven protrusion and adhesion.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071803","count":4},{"id":"GO:0051660","count":4},{"id":"GO:0034260","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0071800","count":4}]},{"hash":"2030454373074896311","title":"Actin dynamics and vesicle trafficking","description":"The GO terms cluster around actin cytoskeleton remodeling (filopodium assembly, polymerization, branching, stress fiber assembly) and membrane trafficking processes (ER-to-Golgi transport, COPII vesicle coating regulation, endocytosis). This suggests a cohesive role in coordinating actin-driven membrane trafficking and cell surface remodeling, with supplementary links to junction formation and signaling pathways.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0030041","count":3},{"id":"GO:0097284","count":3},{"id":"GO:0003400","count":3}]},{"hash":"2136321871124833426","title":"Chondrogenesis and cartilage ECM remodeling","description":"This cluster is enriched for terms tied to cartilage formation and skeletal development, notably collagen fibril organization, cartilage condensation, chondrocyte development, and skeletal system development. The presence of a cellular response to FGF stimulus further supports chondrogenic signaling, while hyaluronan catabolic process aligns with ECM remodeling in cartilage. A few terms like monocyte aggregation are present but do not define the main function of the cluster.","confidence":"High","size":8,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0001502","count":1},{"id":"GO:0044344","count":1},{"id":"GO:1900625","count":1},{"id":"GO:0043154","count":1}]},{"hash":"1292222510245492864","title":"DNA replication and repair with transcription elongation regulation","description":"This cluster centers on genome maintenance processes: DNA-templated DNA replication, DNA repair, and error-free translesion synthesis, plus positive regulation of transcription elongation by RNA polymerase II. Ubiquitin-specific protease activity regulation and oxidative stress response further support a DNA damage response and transcription control theme, with a secondary signal of intracellular trafficking. Overall, the dominant theme is genome maintenance and transcription regulation.","confidence":"High","size":8,"edges":13,"triangles":10,"max_degree":6,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006261","count":5},{"id":"GO:0070987","count":4},{"id":"GO:0071897","count":4},{"id":"GO:0032968","count":3},{"id":"GO:0006281","count":3}]},{"hash":"574645790989228577","title":"mRNA processing and spliceosome regulation","description":"The proteins are dominated by post-transcriptional RNA processing functions: mRNA processing, mRNA splicing via the spliceosome, splice site recognition, mRNA modification, and mRNA stabilization, with both positive and negative regulation of splicing. This points to a cohesive theme centered on mRNA maturation and splicing control. A link to translation initiation factor complex assembly may indicate coupling between RNA processing and translation. Overall, the cluster appears to specialize in mRNA maturation and spliceosome-mediated regulation.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:1905663","count":3},{"id":"GO:0097010","count":3},{"id":"GO:0016556","count":3},{"id":"GO:0048026","count":3}]},{"hash":"1200485416855614469","title":"Ubiquitin-Proteasome Regulation of Cell Cycle","description":"Proteins in this cluster are strongly linked to ubiquitination and proteasomal degradation (K48-linked ubiquitination, ubiquitin-dependent protein catabolic process, ERAD), coupled with GO terms for negative regulation of transcription and organ growth. This points to a coordinated role in tagging regulatory proteins for degradation to control cell cycle progression and growth. A few terms (peroxisome import, X-inactivation-related regulation) may reflect broader regulatory connections, but the dominant theme is ubiquitin-proteasome\u2013mediated regulation of cell cycle and growth.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0046621","count":2},{"id":"GO:0070936","count":2}]},{"hash":"1057105505484757786","title":"Unknown","description":"The top GO terms are diverse, spanning nuclear functions (chromatin assembly, rDNA maintenance, nuclear import, meiotic synaptonemal complex), vesicle trafficking (ER to Golgi transport), and immune-related processes (antigen processing, coagulation). With no single cohesive function tying these terms together and no interactions in the cluster, there isn\u2019t a clear label beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0098943","count":1},{"id":"GO:0006607","count":1},{"id":"GO:0048007","count":1}]},{"hash":"1743574642823647509","title":"Stress and nutrient signaling","description":"The cluster features GO terms spanning general stress responses (toxic substances, metal ions, starvation) plus nutrient and growth signaling (nitrogen utilization, growth regulation, lipid metabolism) and DNA repair, suggesting a broad stress-response and nutrient-regulation module rather than a single, narrow function.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":8},{"id":"GO:0006289","count":8},{"id":"GO:0006808","count":8},{"id":"GO:0014810","count":8},{"id":"GO:0040008","count":8}]},{"hash":"1139544169310525712","title":"Xylan biosynthesis and plant cell wall assembly","description":"The top GO terms are dominated by plant-type secondary cell wall biogenesis and cell wall organization, with a specific emphasis on glucuronoxylan biosynthetic process, suggesting a function in synthesizing and assembling xylan-containing wall components. Some glycosylation-related terms may reflect post-translational modifications associated with wall polymers. Overall, the cluster appears to group proteins involved in plant cell wall biosynthesis, especially xylan synthesis and incorporation.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009834","count":3},{"id":"GO:0071555","count":3},{"id":"GO:0010417","count":3},{"id":"GO:0075015","count":2},{"id":"GO:0006688","count":2}]},{"hash":"1789671250901243193","title":"Mitotic checkpoint signaling and spindle elongation","description":"The proteins show enrichment for cell cycle and mitosis-related terms: negative regulation of CDK activity, kinetochore localization, spindle elongation, and mitotic cytokinesis checkpoint signaling, all pointing to regulation of mitosis and chromosome segregation. Some terms (starch catabolic process, habituation) appear as peripheral or incidental annotations and do not define the main theme.","confidence":"High","size":8,"edges":18,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":7},{"id":"GO:0034501","count":7},{"id":"GO:0035335","count":6},{"id":"GO:0043508","count":5},{"id":"GO:0005983","count":5}]},{"hash":"1893556564622255746","title":"Multisystem organogenesis","description":"The top GO terms include retina development, heart development, forebrain development, inner ear development, embryonic cranial skeleton morphogenesis, thyroid gland development, and general multicellular organism development, plus visual perception and locomotory behavior. This pattern indicates proteins involved in organ formation and sensory/nervous system development across multiple tissues rather than a single pathway. Therefore, Multisystem organogenesis is an intuitive, representative label for this cluster.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0030900","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1265692691969846468","title":"Unknown","description":"The GO terms span diverse, unrelated processes (apoptosis, development, metabolism, immune response, and more) with no single shared function, and there are no protein interactions evident, so a cohesive, specific label cannot be inferred.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0007369","count":3},{"id":"GO:0009106","count":3},{"id":"GO:0060992","count":3},{"id":"GO:0021987","count":3}]},{"hash":"347791105408768920","title":"Plant cell wall polysaccharide biosynthesis","description":"The top GO terms cluster around plant-type secondary cell wall biogenesis, cell wall organization, and biosynthesis of major wall polysaccharides such as homogalacturonan and glucuronoxylan, plus galactose metabolism and mucilage biosynthesis. There are also glycosylation terms (O-linked GalNAc and mannose) consistent with wall glycoprotein synthesis in plants. An outlier term related to skeletal muscle regeneration appears unrelated and likely noise. Taken together, the dominant signal points to plant cell wall polysaccharide biosynthesis and glycosylation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016266","count":3},{"id":"GO:0035269","count":3},{"id":"GO:0009834","count":3},{"id":"GO:0071555","count":3},{"id":"GO:0010289","count":3}]},{"hash":"598245479343251830","title":"Actin Cytoskeleton Dynamics and Cell Polarity","description":"The proteins cluster around actin cytoskeleton organization and remodeling (actin cortical patch assembly, actin filament severing regulation) and cell polarity processes (uropod organization, mitotic spindle orientation, T cell polarity), with supporting roles in phagocytosis signaling and membrane domain organization, suggesting a cohesive theme of cytoskeletal dynamics driving movement, polarity, and immune-related functions. Some outliers (Golgi inheritance, ventricle development) appear incidental to the main cytoskeletal/polarity theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":7},{"id":"GO:0021592","count":7},{"id":"GO:0000132","count":7},{"id":"GO:0030049","count":7},{"id":"GO:0032796","count":7}]},{"hash":"1369852434353142901","title":"Cerebellar development and signaling","description":"These proteins are enriched for cerebellar development terms (Bergmann glial differentiation, cerebellar cortex formation), suggesting a cerebellar development theme. The presence of insulin receptor signaling and T cell receptor signaling terms, along with cell cycle-related terms (kinetochore localization, negative regulation of CDK activity) and IL-6 regulation, indicates broader signaling and proliferation control roles. Overall, the cluster appears to reflect neural development with associated signaling and cell-cycle regulation.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060020","count":7},{"id":"GO:0021697","count":7},{"id":"GO:0048679","count":7},{"id":"GO:0008285","count":7},{"id":"GO:0008286","count":7}]},{"hash":"2234948030034309152","title":"Mitotic spindle assembly and cell cycle regulation","description":"Most prominent GO terms are cell cycle, microtubule nucleation, and mitotic spindle pole body duplication, which together point to mitosis and spindle dynamics as the cluster's core function. The other terms\u2014regulation of cytokinesis, calcium response, synaptic vesicle exocytosis, and VEGF signaling modulation\u2014likely reflect broader signaling or cell-type\u2013specific roles of some members, but do not outweigh the central mitotic theme.","confidence":"High","size":8,"edges":13,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":5},{"id":"GO:0007020","count":4},{"id":"GO:1903087","count":4},{"id":"GO:0060487","count":3},{"id":"GO:0030948","count":3}]},{"hash":"1135815075045563727","title":"Neuronal development and synaptic signaling","description":"The top GO terms point to neural development (axonogenesis, visual perception, heart/developmental signals perhaps incidental) and synaptic function (long-term potentiation, excitatory postsynaptic potential, response to muscle activity). While mitotic cell cycle and transcription terms are present, the dominant theme appears to be neuron formation and synaptic communication, justifying this as the cluster\u2019s label.  ","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0000086","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0007507","count":3}]},{"hash":"993667164508961299","title":"Telomere maintenance and DNA replication/repair","description":"This cluster is driven by terms related to telomere maintenance (telomere lengthening and localization to telomeres) and core genome integrity processes (DNA replication, DNA repair, and mitotic cell cycle checkpoint signaling), suggesting a cohesive theme of preserving genome stability at chromosome ends and during replication. Some mitochondrial tRNA aminoacylation and lysylation terms appear as outliers, possibly reflecting multifunctional proteins or annotation noise, but do not override the dominant telomere/DNA maintenance signal.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072581","count":2},{"id":"GO:0071915","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0007093","count":2},{"id":"GO:0006260","count":2}]},{"hash":"2292632997800128576","title":"Nuclear architecture and bone remodeling regulation","description":"The cluster mixes bone-related processes (positive regulation of osteoblast differentiation, positive regulation of collagen biosynthetic process, regulation of bone remodeling) with nuclear organization terms (nuclear matrix anchoring at nuclear membrane, centromere clustering, centrosome localization, regulation of DNA-templated transcription), suggesting proteins that connect nuclear architecture to osteogenesis. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":2},{"id":"GO:0045669","count":2},{"id":"GO:0090292","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0072766","count":2}]},{"hash":"264931614461029703","title":"Carbohydrate and amino acid metabolism with quorum sensing","description":"The top GO terms point to diverse metabolic activities focused on carbohydrates (D-xylose, rhamnose, carbohydrate phosphorylation) and amino acids (L-glutamine), plus biosynthesis routes (thiamine, PRPP) and a signaling cue (quorum sensing). This suggests a metabolically focused cluster with occasional signaling associations rather than a single, tight pathway. Confidence: Medium","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":3},{"id":"GO:0046835","count":3},{"id":"GO:0009229","count":2},{"id":"GO:0009228","count":2},{"id":"GO:0006015","count":2}]},{"hash":"1742710944948709791","title":"Chromatin organization and nucleosome assembly","description":"The top GO terms cluster around chromatin architecture, nucleosome assembly, and histone modification (e.g., H3K27me3, H3K4me3) with heterochromatin organization, indicating proteins involved in chromatin packaging and nuclear architecture. Despite a couple terms being obsolete, the overall theme points to chromatin organization and nucleosome dynamics.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":7},{"id":"GO:0098532","count":7},{"id":"GO:0070828","count":7},{"id":"GO:0016584","count":7},{"id":"GO:0097298","count":7}]},{"hash":"1998949282279092618","title":"Nuclear transport, mitosis, and telomere maintenance","description":"This cluster centers on nuclear organization and regulation: nuclear transport components (nuclear pore assembly, protein import into nucleus), mitotic control (G2/M transition), mitotic nuclear envelope dynamics (membrane reassembly), and telomere maintenance (telomerase regulation and telomere capping). The recurring theme is proteins involved in nuclear structure and division, with telomere regulation as a related nuclearlike function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0032212","count":1},{"id":"GO:0010389","count":1},{"id":"GO:0042308","count":1},{"id":"GO:0051973","count":1}]},{"hash":"1521176412435685600","title":"Histone modification and nucleosome assembly","description":"The top GO terms are dominated by histone modification (H3K27 trimethylation; H3K4 dimethylation/trimethylation; H3 acetylation) and nucleosome assembly, pointing to chromatin regulation. A few development- or stress-related terms appear but are likely secondary or reflect pleiotropy; overall the cluster centers on chromatin remodeling and histone modification.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098532","count":2},{"id":"GO:0044648","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0080182","count":2},{"id":"GO:2001040","count":2}]},{"hash":"2301439355890294471","title":"Retrotransposon and Proviral Integration","description":"The top GO terms cluster around DNA transposition, retrotransposition, DNA integration, and proviral latency, indicating a focus on mobile genetic elements and genome integration events (including proviral latency and viral entry into host nucleus). While there are a few general cellular processes (translation, tRNA/mRNA pseudouridine synthesis) mentioned, they are peripheral to the dominant transposon/provirus theme. Overall, the cluster seems centered on retroelement activity and genome integration mechanisms.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0075713","count":1}]},{"hash":"2044183646962273028","title":"Golgi vesicle trafficking and SNARE assembly","description":"Dominant GO terms describe vesicle transport between ER and Golgi, intra-Golgi transport, SNARE complex assembly, and Golgi ribbon formation, indicating a core role in Golgi-centric secretory trafficking. Degranulation terms for eosinophils, natural killer cells, and neutrophils reflect secretory granule release via vesicle fusion, reinforcing the vesicle trafficking theme. Overall, the cluster likely groups proteins involved in Golgi-mediated vesicle transport and related vesicle fusion processes.","confidence":"High","size":8,"edges":14,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0035493","count":5},{"id":"GO:0048280","count":5},{"id":"GO:0006891","count":5},{"id":"GO:0043308","count":4}]},{"hash":"1189020695320517682","title":"Neurodevelopment and Forebrain Patterning","description":"This cluster centers on embryonic development with a strong emphasis on neural fate and brain patterning, including neuron migration, forebrain development, cerebral cortex regionalization, and motor neuron differentiation. While there are a few outliers touching on broader developmental processes (primitive streak formation, craniofacial and organogenesis events), the dominant signal is neural development and forebrain specification during early development.","confidence":"High","size":8,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":6},{"id":"GO:0001764","count":5},{"id":"GO:0061452","count":5},{"id":"GO:0030900","count":5},{"id":"GO:0060971","count":5}]},{"hash":"766132246436783930","title":"Neural development and synapse assembly","description":"The top GO terms point to neural development and synapse formation (axonal fasciculation, CNS development, positive regulation of synapse assembly), indicating a cluster enriched for neuronal wiring processes. Some terms such as angiogenesis, phagocytosis, and sarcomere organization are less central but may reflect context-specific roles in neural tissues.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":2},{"id":"GO:0000187","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007417","count":2},{"id":"GO:0048671","count":2}]},{"hash":"1066726347595063623","title":"Fibrosis regulation and ECM remodeling","description":"The proteins appear enriched for processes related to tissue remodeling and fibrotic regulation, including negative regulation of collagen biosynthesis, hepatic stellate cell activation, and fibroblast migration, along with oxidative stress responses and coagulation. Some terms like nitrogen fixation and renal transport are outliers, but the dominant theme centers on fibrosis modulation and extracellular matrix dynamics.","confidence":"Medium","size":8,"edges":18,"triangles":17,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009399","count":4},{"id":"GO:2000490","count":4},{"id":"GO:0032966","count":4},{"id":"GO:0009636","count":4},{"id":"GO:0007596","count":4}]},{"hash":"750009753585120629","title":"Neuronal development and synapse formation","description":"The top GO terms cluster around brain development, synapse assembly, and GABAergic synaptic transmission, with Purkinje cell development and axon guidance signaling reinforcing a neural development and connectivity theme. There are a few non-neural terms (ureter maturation, lipid tube assembly, blood vessel maturation) that may reflect broader or multi-functional proteins or annotation noise, but the overall pattern is strongly neural and synaptic.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0007416","count":5},{"id":"GO:0035799","count":4},{"id":"GO:0060489","count":4},{"id":"GO:0016339","count":4}]},{"hash":"1200225046103203164","title":"Unknown","description":"The GO terms span metabolism (nicotinamide nucleotide metabolism, prostaglandin biosynthesis, fatty acid import, glucose transport), immune-related activities (complement activation, cytokine production), ciliary motility regulation, and behavior (startle response, feeding behavior). This broad mix lacks a single coherent function or pathway tying the proteins together, so there isn\u2019t a clear, specific label beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046496","count":1},{"id":"GO:0018095","count":1},{"id":"GO:0060296","count":1},{"id":"GO:2000253","count":1},{"id":"GO:0001516","count":1}]},{"hash":"270186962877499796","title":"Oocyte development and fertilization signaling","description":"The terms cluster around reproductive biology: oocyte development, sperm-egg interaction (binding to zona pellucida), acrosomal exocytosis, and hormone signaling (FSH, GnRH), with supporting roles for cell-matrix adhesion and TGF-beta receptor assembly, suggesting a group of proteins involved in gamete interaction and oogenesis. Some terms appear peripheral (e.g., maltose transport, heart morphogenesis), but the core theme fits reproduction and fertilization processes.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0032753","count":1},{"id":"GO:0015768","count":1},{"id":"GO:0097211","count":1},{"id":"GO:2000368","count":1}]},{"hash":"706279019539234962","title":"Endosomal trafficking and autophagy regulation","description":"Based on the enriched GO terms, the proteins cluster around endosomal-lysosomal trafficking and autophagy control, including transport between membrane compartments (plasma membrane to endosome, endosome to Golgi, lysosome localization) and regulation of autophagosome maturation, with Rab/Rap GTPase signaling and GTPase activity emphasizing vesicle trafficking control.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:1903527","count":5},{"id":"GO:0043553","count":3},{"id":"GO:1901098","count":3},{"id":"GO:0034499","count":3},{"id":"GO:0048227","count":3}]},{"hash":"1606218384228699166","title":"Membrane transport of nutrients and ions","description":"The top GO terms are dominated by transmembrane transport activities for diverse substrates (phosphate and sodium ions, nitrite, dehydroascorbic acid, xenobiotics), pointing to a coherent theme of membrane transporters handling small molecules and ions. Some metabolism-related terms (fucose and lactose biosynthesis) may reflect related pathways or substrate contexts, and one outlier term on replicative senescence appears unrelated. Overall, the cluster centers on membrane transport functions.","confidence":"High","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1904728","count":8},{"id":"GO:0070837","count":8},{"id":"GO:0042891","count":8},{"id":"GO:0006004","count":8},{"id":"GO:0015707","count":8}]},{"hash":"830955497167396417","title":"Embryonic Development and Patterning","description":"The GO terms cluster around embryogenesis and tissue morphogenesis, including mesoderm development, left-right patterning, placental and cartilage formation, and EMT events in heart cushion formation, with additional signals for endocrine and pancreatic lineage development. This points to a cohesive theme of early developmental processes and organ patterning rather than a single molecular activity.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5}]},{"hash":"1166991262429676441","title":"Innate Immune Receptor Signaling and Phagocytosis","description":"The top GO terms cluster around phagocytosis recognition, C-type lectin receptor signaling, and Fc-gamma receptor signaling, plus basophil and platelet activation, indicating a shared role in innate immune recognition and phagocytic/immune activation processes. Some morphogenesis terms appear less related and may reflect broader or pleiotropic functions, but the dominant theme is immune cell activation and phagocytosis.","confidence":"High","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":7},{"id":"GO:0001502","count":5},{"id":"GO:0051873","count":5},{"id":"GO:0002223","count":5},{"id":"GO:0038094","count":5}]},{"hash":"229024615292546951","title":"Immune cell differentiation and signaling","description":"The cluster is driven by terms for dendritic cell and B cell differentiation, cytokine production and signaling (including STAT and BMP pathways), and immune-related processes, suggesting a core theme of immune cell development and signal transduction. Some terms reference vascular and nervous system development, indicating broader developmental context, but the dominant signal is immune differentiation and signaling.","confidence":"Medium","size":7,"edges":10,"triangles":10,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042523","count":7},{"id":"GO:2001200","count":7},{"id":"GO:0001923","count":7},{"id":"GO:0030513","count":7},{"id":"GO:1904597","count":7}]},{"hash":"522440718680918613","title":"Fungal Stress Response and Development","description":"The GO terms point to protein folding and ER stress management (unfolded protein response, chaperone-related refolding) alongside fungal-specific processes (beta-glucan cell wall biosynthesis, karyogamy, cell morphogenesis, membrane targeting). This suggests a coordinated fungal growth and development program that is modulated by cellular stress and protein quality control, rather than a single, narrow function. ","confidence":"Medium","size":7,"edges":15,"triangles":14,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1903382","count":5},{"id":"GO:1900035","count":5},{"id":"GO:0000742","count":5},{"id":"GO:0000902","count":5},{"id":"GO:0034620","count":5}]},{"hash":"764393331543715896","title":"Embryonic organ morphogenesis and muscle differentiation","description":"This cluster centers on developmental and morphogenetic processes across multiple tissues, with GO terms including sinus venosus morphogenesis, cardiac right ventricle formation, diaphragm development, metanephric nephron morphogenesis, and S-shaped body morphogenesis, plus regulatory roles in myoblast proliferation and skeletal muscle differentiation, and circadian control of gene expression. Together, these suggest proteins involved in embryonic organogenesis and muscle development rather than a single tissue pathway.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0003236","count":7},{"id":"GO:0003219","count":7},{"id":"GO:0070368","count":7},{"id":"GO:0032922","count":7},{"id":"GO:0072050","count":7}]},{"hash":"881905304890341709","title":"Multitissue Differentiation Regulators","description":"The top GO terms cluster around differentiation across many tissues (neurons, enterocytes, pancreatic B cells, ureter, erythrocytes, adipocytes) and include BMP/TGF-beta\u2013related signaling, suggesting a general theme of regulation of cell differentiation and developmental signaling rather than a single tissue-specific function. This implies the proteins contribute to lineage commitment and differentiation programs across multiple lineages.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032911","count":7},{"id":"GO:0035799","count":7},{"id":"GO:2000977","count":7},{"id":"GO:0003309","count":7},{"id":"GO:1903703","count":7}]},{"hash":"1237905686314349232","title":"DNA damage response and RNA processing factors","description":"The top GO terms show a mix of DNA-related processes (DNA replication, DNA recombination, SOS response) and RNA metabolism/rRNA maturation (SSU/LSU rRNA maturation, RNA exon ligation, spliceosomal disassembly, RNA-protein cross-linking) along with stress granule localization. This suggests a cluster of proteins involved in nucleic acid maintenance and RNA processing, especially under stress, hence the combined label. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0070389","count":2},{"id":"GO:0000462","count":2},{"id":"GO:1903608","count":2},{"id":"GO:0006310","count":2}]},{"hash":"1974756214056820228","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010838","count":2},{"id":"GO:0035799","count":2},{"id":"GO:1904938","count":2},{"id":"GO:0048925","count":2},{"id":"GO:1903142","count":2}]},{"hash":"1157724618089630734","title":"Nucleotide salvage and catabolic metabolism","description":"The top GO terms cluster around nucleotide salvage (UMP salvage) and interconversion (purine nucleoside interconversion) as well as various nucleotide catabolic processes (uridine, deoxyguanosine, overall nucleotide catabolism), pointing to a cohesive theme of nucleotide turnover. A few immune-related terms (interleukin-2 production, T cell differentiation) appear but are likely contextual rather than defining the cluster\u2019s main function.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070970","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0046115","count":2},{"id":"GO:0019686","count":2}]},{"hash":"1692505805148931143","title":"Immune-vascular signaling","description":"This cluster's terms strongly emphasize immune defense (adaptive immune response, antibacterial humoral response, defense against Gram-positive bacteria, NK cell\u2013mediated cytotoxicity) alongside vascular remodeling cues (angiogenesis, endothelial cell chemotaxis via VEGF signaling). While nervous system terms are present (nerve impulse transmission, mechanosensation, heart rate regulation), the dominant theme appears to be the interplay between immune activity and vascular dynamics, suggesting a shared signaling axis in inflammation or tissue remodeling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":3},{"id":"GO:0050910","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0019731","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1378500385406948648","title":"Axon guidance and neuronal migration","description":"The top GO terms cluster around neural development: axonal fasciculation, regulation of axon extension, branching morphogenesis of a nerve, and cerebral cortex radial glia-guided migration, suggesting roles in guiding axons and neuron positioning. Some terms reference general organelle organization (ER tubular networks, nuclear pore assembly), but the neural-development signals are the strongest theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000172","count":2},{"id":"GO:0051292","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0071787","count":2},{"id":"GO:0032581","count":2}]},{"hash":"2255043011097253710","title":"Actin Cytoskeleton Remodeling","description":"The top GO terms cluster around actin-related processes (actin filament depolymerization, cortical actin cytoskeleton organization, smooth muscle contraction), indicating a shared theme of actin cytoskeleton remodeling and related motility/contraction functions. While metabolism and developmental terms appear, the dominant signal is cytoskeletal dynamics and its regulation, possibly linked to HGF signaling that promotes cytoskeletal changes.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":3},{"id":"GO:0009247","count":2},{"id":"GO:0019417","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0030900","count":2}]},{"hash":"2002045200561530554","title":"Ribosome biogenesis and translation initiation","description":"The strongest signals are LSU rRNA maturation and the formation of the translation preinitiation complex, with TORC1 signaling linking growth to ribosome production. These together point to ribosome assembly and the initiation of protein synthesis as the core function of the cluster. Other terms (mRNA transport, GTPase regulation, and peptidyl-serine dephosphorylation) may reflect broader regulatory connections, while developmental terms are peripheral. ","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051028","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0038202","count":2}]},{"hash":"542562967158597614","title":"Hair follicle development and cytoskeletal organization","description":"The GO terms cluster around skin/hair follicle biology (hair follicle cell proliferation, melanosome assembly), cell polarity/junctions (apical junction assembly), and cytoskeletal remodeling (actin filament branching, Cdc42/Ras signaling, nuclear migration, mitochondrial distribution). This suggests a coherent function in hair follicle morphogenesis with a strong emphasis on cytoskeletal dynamics and cell adhesion. ","confidence":"Medium","size":7,"edges":4,"triangles":1,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0032966","count":4},{"id":"GO:0051291","count":4},{"id":"GO:1903232","count":3},{"id":"GO:0071338","count":3},{"id":"GO:0043297","count":3}]},{"hash":"2237375325265093295","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071031","count":7},{"id":"GO:0000462","count":7},{"id":"GO:1903608","count":7},{"id":"GO:0071049","count":7},{"id":"GO:0006268","count":7}]},{"hash":"1910570807741468875","title":"Viral assembly and release","description":"Most prominent GO terms are virion assembly, viral release from host cell, and fusion of virus membrane with host plasma membrane, pointing to a core theme of viral life cycle and virus\u2013host interactions. Some other terms relate to host RNA processing and lipid droplet organization, which can be involved in viral replication or be incidental. An outlier term for sepals formation is likely annotation noise. Overall, the cluster centers on viral assembly and egress processes.","confidence":"Medium","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":"protein folding","top_go_terms":[{"id":"GO:0010610","count":5},{"id":"GO:1901407","count":4},{"id":"GO:0000381","count":4},{"id":"GO:0019064","count":3},{"id":"GO:0010849","count":3}]},{"hash":"1120500545745782631","title":"Vacuolar amino acid transport","description":"Most GO terms are about transmembrane import of amino acids (serine, arginine, histidine, tyrosine, asparagine) into the vacuole, suggesting a clustered function in vacuolar amino acid import/transport. A couple of terms (cell migration, potassium starvation response) are less central but do not override the main theme. Confidence: Medium","confidence":"","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":2},{"id":"GO:0007205","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0006867","count":2},{"id":"GO:0090516","count":2}]},{"hash":"168772078051062728","title":"Oxidative Stress Response and Redox Regulation","description":"The cluster is enriched for GO terms related to responses to hydrogen peroxide and oxidative-reduction processes, plus associated stress signaling and mitochondrial redox activity, indicating a cohesive redox-homeostasis module.","confidence":"High","size":7,"edges":16,"triangles":16,"max_degree":6,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0070301","count":4},{"id":"GO:0017004","count":4},{"id":"GO:0022417","count":4},{"id":"GO:0033195","count":4},{"id":"GO:0042345","count":4}]},{"hash":"769250007328245561","title":"Unknown","description":"The listed GO terms span multiple, seemingly unrelated biological areas: development (gastrulation, cerebral cortex development), hematopoiesis (megakaryocyte and erythrocyte differentiation), epigenetic/DNA methylation, metabolism (lipoate), defense (response to fungicide, lipopolysaccharide), and neural signaling (serotonin secretion). This dispersion indicates no single coherent functional theme for the cluster, suggesting the proteins are functionally diverse or noisy.","confidence":"","size":7,"edges":11,"triangles":5,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051572","count":5},{"id":"GO:0045654","count":5},{"id":"GO:0043046","count":5},{"id":"GO:0007369","count":4},{"id":"GO:0009106","count":4}]},{"hash":"1016413001131711427","title":"Neural development and sensory perception","description":"The shared GO terms cluster around nervous system development, sensory perception (pain and vision), dendrite morphogenesis, and potassium ion transport, pointing to neuronal differentiation and function. Transcriptional regulation and nuclear export also fit developmental coordination. Overall, the proteins appear to be linked to neural development and sensory signaling.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0046827","count":6},{"id":"GO:0007399","count":5}]},{"hash":"312633228574969428","title":"Unknown","description":"The top GO terms are highly diverse, including cellular response to ionizing radiation, regulation of actin assembly, translational elongation and fidelity, membrane raft polarization, myelination, transcytosis, eisosome assembly, apoptosis signaling, and substantia nigra development. This lack of a shared biological theme or pathway among the terms suggests there isn't a coherent function tying these proteins together, so a single meaningful label cannot be assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071479","count":1},{"id":"GO:0032232","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0006414","count":1},{"id":"GO:0001766","count":1}]},{"hash":"987104371509393439","title":"ECM remodeling and cell adhesion regulation","description":"The top GO terms cluster around extracellular matrix disassembly and regulation of cell\u2013cell adhesion molecules (cadherin-mediated adhesion, adhesion molecule production), which together point to extracellular matrix remodeling and cell\u2013cell interaction control. While lipid localization, cholesterol biosynthesis regulation, excretion, and some mitochondrial processes appear, the strongest and most cohesive signal is ECM remodeling and adhesion dynamics.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010876","count":5},{"id":"GO:0010918","count":5},{"id":"GO:1903905","count":5},{"id":"GO:0045541","count":5},{"id":"GO:0007588","count":5}]},{"hash":"284319231751332621","title":"Broad developmental morphogenesis across tissues","description":"The proteins are enriched for a range of developmental GO terms, including peripheral nervous system development, heart development, somitogenesis, photoreceptor axon guidance, and megakaryocyte development, along with cell adhesion and signaling (TGF-beta, Rho). This pattern points to a general role in morphogenesis and tissue development across multiple lineages rather than a single, specific function.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007422","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0001756","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1641592501290132968","title":"Insect larval neurodevelopment and morphogenesis","description":"The GO terms cluster around developmental processes during larval stages, especially neural development (neurogenesis, CNS remodeling) and tissue morphogenesis (larval salivary gland morphogenesis), with supports from growth-factor signaling and DNA metabolism regulation. Some terms, like \"vagina development\" and an obsolete fusion term, are less informative, but the dominant theme is larval development and neural/tissue morphogenesis in insects. Therefore this label is a reasonable representation of the cluster.","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060068","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0022008","count":3},{"id":"GO:0007436","count":2}]},{"hash":"1356560227407022162","title":"Nucleotide Biosynthesis and Cofactor Metabolism","description":"The top GO terms cluster around nucleotide metabolism and cofactor biosynthesis (AMP salvage, NAD+ and CoA biosynthesis, various nucleotide phosphorylations and interconversions). Brain and liver development terms likely reflect tissue expression context rather than core function. Overall, the group points to a cohesive theme of nucleotide and cofactor production and modification.","confidence":"High","size":7,"edges":16,"triangles":16,"max_degree":6,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0044209","count":6},{"id":"GO:0015937","count":4},{"id":"GO:0015951","count":4},{"id":"GO:0046705","count":4},{"id":"GO:0046041","count":4}]},{"hash":"2063302161953508013","title":"Cerebellar development and neural differentiation","description":"The top GO terms point to neural development and cerebellar lineage, including cerebellar cortex formation, Bergmann glial cell differentiation, forebrain development, and regulation of axon regeneration. While there are also growth and signaling terms (insulin signaling, CDK activity regulation) that touch on broader cell-cycle and metabolic processes, the strongest and most coherent signal across the cluster is neural development and cerebellar differentiation, suggesting proteins that participate in cerebellar formation and neuronal differentiation programs.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0021697","count":7},{"id":"GO:0048679","count":7},{"id":"GO:0045736","count":7}]},{"hash":"1866631902316735821","title":"Embryonic bone and vascular development with nociception","description":"The cluster highlights developmental processes in which bone formation/remodeling (ossification), blood vessel formation (vasculogenesis), and neural tube closure are key, alongside pain-related signaling (sensory perception of pain, nociception). This suggests a coherent theme of embryonic skeletal and vascular development with associated sensory pathways.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":2},{"id":"GO:0001570","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0045778","count":1},{"id":"GO:0045779","count":1}]},{"hash":"2225643620007105740","title":"Reproductive development and gametogenesis","description":"The proteins are enriched for GO terms tied to reproductive processes across species\u2014luteinization, pollen and embryo sac development, and maternal pregnancy-related terms\u2014suggesting a common theme in gametogenesis and reproductive physiology. Some non-specific terms (fibroblast migration, hippo signaling, DNA repair) are less central but may reflect broader developmental roles; overall, the cluster centers on reproductive development.","confidence":"Medium","size":7,"edges":12,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001553","count":2},{"id":"GO:0010761","count":2},{"id":"GO:0035332","count":2},{"id":"GO:0006302","count":1},{"id":"GO:0009555","count":1}]},{"hash":"278320419913835140","title":"Hair Keratinization and Hair Cycle","description":"The dominant GO terms are keratinization and hair cycle, pointing to proteins involved in the formation and turnover of hair structures. This cluster likely represents hair structural proteins (keratins and companions) tied to the hair cycle.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":7},{"id":"GO:0042633","count":7}]},{"hash":"860831390063900946","title":"Vertebrate developmental transcription and signaling","description":"These proteins are enriched for vertebrate development terms (gastrulation, forebrain development, skeletal system morphogenesis) and for DNA-templated transcription, suggesting a role in transcriptional regulation during development. Additional terms point to signaling (PDGF, growth hormone) and cytoskeletal remodeling (actin depolymerization), which together imply coordinated developmental regulation rather than a single narrow pathway. Overall, the cluster seems to reflect vertebrate developmental transcriptional control and associated signaling.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0048304","count":2},{"id":"GO:0007369","count":1},{"id":"GO:0030900","count":1}]},{"hash":"1155334083441135668","title":"Sulfur metabolism and redox with tRNA modification","description":"The cluster\u2019s top GO terms heavily emphasize sulfur-related processes (transsulfuration, redox homeostasis, Mo-molybdopterin cofactor biosynthesis) and RNA tRNA modifications (wobble thiolation, seleno-modification), suggesting a core theme of sulfur-based metabolism and redox chemistry linked to tRNA modification. Some other terms (glycerol metabolism, developmental processes) may be context-specific noise, but do not override the main sulfur/redox signal.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0018192","count":5},{"id":"GO:0045454","count":5},{"id":"GO:0019346","count":5},{"id":"GO:0006777","count":5},{"id":"GO:0006071","count":5}]},{"hash":"1391414354290812385","title":"Amino acid metabolism and lipid biosynthesis","description":"The top GO terms indicate multiple amino acid\u2013related processes (glyoxylate, lysine, tryptophan, alanine) alongside lipid/sphingolipid biosynthesis and related transport and cofactor pathways (biotin, heme), with some signaling context. This points to a cluster centered on diverse metabolic activities spanning amino acid turnover and lipid biosynthesis rather than a single isolated function. ","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009436","count":4},{"id":"GO:0033362","count":3},{"id":"GO:0019441","count":3},{"id":"GO:0015908","count":3},{"id":"GO:0009102","count":3}]},{"hash":"1278699081694044932","title":"Multiorgan Development and Transcription Regulation","description":"The cluster pulls together diverse developmental processes (gonad, heart, face, prostate development) with transcriptional control terms, implying proteins that regulate developmental programs across multiple tissues at the transcription level.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0060528","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0007507","count":2}]},{"hash":"953294592525517275","title":"Dopaminergic GPCR signaling regulation and interneuron migration","description":"This cluster centers on terms related to dopamine receptor signaling inhibition, GPCR/adenylate cyclase pathways, and dopamine transport, with a notable link to cortical interneuron migration. While several other terms appear unrelated (e.g., cell wall catabolic processes and thymocyte differentiation), the core theme points to dopaminergic signaling regulation and neural development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":7},{"id":"GO:0090075","count":7},{"id":"GO:0007194","count":7},{"id":"GO:0016998","count":7},{"id":"GO:0040015","count":7}]},{"hash":"1312310295930601292","title":"Unknown","description":"The top GO terms are scattered across aging, gamete DNA methylation, immune migration and inflammatory responses, keratinocyte differentiation, metal ion response, chondrocyte regulation, Notch signaling, pancreatic and prostate gland development. There isn\u2019t a single coherent process or pathway linking these terms, suggesting no clear functional theme for the cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0002523","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0010042","count":2}]},{"hash":"867164734892387081","title":"Cardiac development and electrophysiology","description":"This cluster centers on heart morphogenesis and electrical activity: outflow tract morphogenesis, regulation of heart rate by cardiac conduction, AV node and His bundle\u2013related membrane depolarization, atrial action potential regulation, and calcium-driven transmembrane transport via high-voltage\u2013gated calcium channels, plus calcium-dependent cell\u2013matrix adhesion. While ossification and stress fiber assembly appear, the dominant theme is cardiac development and electrophysiology supported by calcium signaling and ECM interactions.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":5},{"id":"GO:0043149","count":3},{"id":"GO:0003151","count":3},{"id":"GO:0086091","count":3},{"id":"GO:0086045","count":3}]},{"hash":"547082909955849869","title":"Vertebrate organ development and patterning","description":"The top GO terms cluster around development of multiple organs (hypothalamus, heart, spleen, liver) and pattern specification, with nodal signaling linking to early vertebrate development. While some biosynthetic process terms appear, the dominant theme is organogenesis and developmental patterning, suggesting a developmental module rather than metabolism. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0021854","count":2}]},{"hash":"951885784627089539","title":"Steroid and lipid biosynthesis","description":"The top GO terms are dominated by lipid- and steroid-related biosynthetic and metabolic processes, including 3-keto-sphinganine metabolic process (sphingolipids), mycolic acid biosynthesis (lipid-rich cell walls), and testosterone biosynthetic process and steroid catabolic process. While a few terms like lung development or sporulation appear, the strongest signals point to lipid and steroid metabolism and biosynthesis as the cohesive theme of this cluster.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0031427","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0009710","count":3},{"id":"GO:0042619","count":3}]},{"hash":"202742430423187782","title":"Plant gravity sensing via amyloplasts","description":"The strongest signals in the GO terms are related to gravity sensing and amyloplast organization (detection of gravity, negative gravitropism, amyloplast organization), which is characteristic of plant cells. Additional terms like lipid droplet and mitochondrial dynamics suggest broader cellular housekeeping but do not override the gravity/amyloplast theme. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0032258","count":2},{"id":"GO:0009959","count":1},{"id":"GO:0090141","count":1},{"id":"GO:0034389","count":1}]},{"hash":"1011209921829477359","title":"Wnt signaling in embryonic development","description":"The top GO terms center on the Wnt signaling pathway and multiple embryonic development processes (left-right patterning, EMT in heart development, cartilage morphogenesis, endocrine development), indicating a coherent theme of Wnt-regulated developmental signaling. While there are a couple of exocytosis and phototaxis terms, they are less representative of the cluster\u2019s main function. Therefore, the label reflects the dominant theme of developmental signaling driven by Wnt.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0006904","count":1},{"id":"GO:0090522","count":1},{"id":"GO:0042331","count":1},{"id":"GO:0060707","count":1}]},{"hash":"1460198045077145804","title":"Chromatin Assembly and Epigenetic Regulation","description":"The dominant signals are nucleosome assembly and regulation of transcription by chromatin state, including histone modification processes and DNA methylation regulation. The presence of male gonad development and animal organ development hints at a developmental role, likely via chromatin- or epigenetic-mediated control of gene expression. Despite many terms being obsolete, the core theme points to chromatin organization coordinating transcription during development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901536","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0010216","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0035522","count":2}]},{"hash":"1625516284048240954","title":"Developmental gene regulation via chromatin remodeling","description":"The top terms cluster around chromatin assembly/remodeling, transcription initiation and Pol II\u2013mediated regulation, and heterochromatin formation, all pointing to chromatin-state control of gene expression. The developmental terms (osteoblast differentiation, pericardium and male gonad development) suggest this regulation is particularly relevant to development, while mRNA turnover/quality control terms imply coordinated transcription and RNA processing. Confident that the cluster reflects chromatin- and transcription-associated developmental regulation, with some broad developmental contexts included.","confidence":"Medium","size":7,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001649","count":5},{"id":"GO:0003344","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0071674","count":4}]},{"hash":"1518627022272396106","title":"Neural development and Wnt signaling","description":"The top GO terms suggest a strong emphasis on neural development processes (axonogenesis, neural tube closure) and signaling pathways (positive regulation of canonical Wnt signaling), along with related morphogenetic processes (centrosome cycle, tight junction regulation, angiogenesis). Although there are a couple of immune-related terms, the core pattern centers on neuronal development and Wnt-driven signaling during embryogenesis, making this a cohesive developmental group rather than an immune-focused cluster.","confidence":"Medium","size":7,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0031532","count":2},{"id":"GO:2000810","count":2},{"id":"GO:0007409","count":2}]},{"hash":"490773555630983732","title":"Neural development and synapse assembly regulation","description":"The top terms cluster around neural development and synaptic processes (forebrain development, positive regulation of synapse assembly, cell-matrix adhesion) and are tied to growth/survival signaling (PI3K/AKT, nitric oxide) and apoptotic modulation, suggesting a role in neural development and synapse establishment/maintenance. Some terms reference eye morphogenesis or adipogenesis, but the dominant theme is neural development and synaptic regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030900","count":4},{"id":"GO:0051897","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0034351","count":4}]},{"hash":"1459514885400438966","title":"Dopaminergic GPCR signaling regulation","description":"The top GO terms cluster around regulation of dopamine receptor signaling, dopamine transport, and GPCR- and adenylate cyclase\u2013mediated pathways, suggesting a shared theme of dopaminergic neurotransmission modulation. While a few terms touch on unrelated processes (cell wall catabolism, thymocyte differentiation), the dominant theme is dopaminergic GPCR signaling regulation. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":7},{"id":"GO:0090075","count":7},{"id":"GO:0007194","count":7},{"id":"GO:0016998","count":7},{"id":"GO:0040015","count":7}]},{"hash":"622066559709365457","title":"Placental and Embryonic Development","description":"GO terms point to embryogenesis with emphasis on placental differentiation (trophoblast giant cell differentiation, placenta development) and early organogenesis (left-right patterning, EMT in heart development, cartilage morphogenesis, pancreatic endocrine development). Together these terms define proteins involved in placental and embryonic development rather than late-stage tissue maintenance.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0003198","count":3}]},{"hash":"386070774305043759","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061146","count":2},{"id":"GO:0003222","count":2},{"id":"GO:0045662","count":2},{"id":"GO:0032331","count":2},{"id":"GO:0030326","count":2}]},{"hash":"2086481390518434817","title":"Unknown","description":"The top GO terms cover neural signaling (positive regulation of synaptic transmission, long-term neuronal synaptic plasticity, prepulse inhibition, regulation of sensory perception of pain) alongside signaling processes (MAPK activity, adenylate cyclase regulation) and unrelated processes (negative regulation of oocyte maturation, cell wall macromolecule catabolic process, response to fungicide, viral release from host cell). This dispersion suggests no single cohesive function linking the cluster, and the lack of edges supports a heterogeneous or misannotated set rather than a shared pathway.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":5},{"id":"GO:0051930","count":5},{"id":"GO:0000187","count":5},{"id":"GO:0007194","count":5},{"id":"GO:0016998","count":5}]},{"hash":"51411304140229657","title":"Neural Sensory Signaling and Differentiation","description":"The top GO terms cluster around neural function: detection of mechanical and temperature stimuli (pain, thermoception), cerebellar granule cell differentiation, and regulation of SNARE-mediated synaptic assembly, pointing to neural signaling and development as the cluster\u2019s main theme; less central terms like cell cycle regulation, angiogenesis, and PARP activity may reflect protein multifunctionality but do not redefine the cluster.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":3},{"id":"GO:0016049","count":3},{"id":"GO:0050966","count":2},{"id":"GO:0035544","count":2},{"id":"GO:0050960","count":2}]},{"hash":"454509927568796963","title":"RNA processing and ribosome assembly","description":"This cluster is dominated by RNA-centric processes: splicing via spliceosome, ribosomal large subunit biogenesis, and formation of the translation preinitiation complex, pointing to RNA processing and ribosome/translation machinery. Protein homooligomerization supports assembly aspects common to these complexes. Some terms (GPCR signaling regulation, ubiquitination, cadmium response, acetylcholine receptor clustering) are more divergent, but the core signal is RNA processing and ribosome assembly.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0008277","count":2}]},{"hash":"29132939848431313","title":"Dopaminergic-GABAergic Neurotransmission Regulation","description":"The cluster is dominated by neural signaling terms: dopamine signaling and transport, GPCR-mediated control of adenylate cyclase, acetylcholine receptor signaling, and GABAergic interneuron migration, all pointing to modulation of neuronal communication and fear/muscle regulation. A few terms (e.g., cell wall catabolic process, growth regulation) seem less connected and may reflect annotation noise; overall the theme centers on neuromodulatory signaling in the brain. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001662","count":5},{"id":"GO:0060160","count":4},{"id":"GO:0090075","count":4},{"id":"GO:0007194","count":4},{"id":"GO:0016998","count":4}]},{"hash":"950017944949367945","title":"Immune signaling and leukocyte adhesion","description":"This cluster centers on immune regulation and leukocyte trafficking, with GO terms about regulating NK and T cell activity, cytokine production, dendritic cell differentiation, neutrophil extravasation, and adhesion/cytoskeleton dynamics (actin organization by cell-cell adhesion, endothelial adhesion). The common theme is coordinated immune signaling coupled with leukocyte adhesion and movement.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090138","count":5},{"id":"GO:0002859","count":5},{"id":"GO:0043318","count":5},{"id":"GO:0002720","count":4},{"id":"GO:0045425","count":4}]},{"hash":"1511661936390603470","title":"Planar Cell Polarity in Morphogenesis","description":"The proteins are linked to planar cell polarity pathways that organize tissue architecture during branching morphogenesis (lung) and body hair orientation, along with adhesion and axon guidance cues. Top terms cluster around planar polarity establishment and morphogenesis across tissues (lung branching, body hair orientation) and guidance (dopaminergic/serotonergic axon guidance). This unifying theme of PCP signaling regulating morphogenesis and guidance justifies the name.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060489","count":5},{"id":"GO:1904938","count":5},{"id":"GO:0060490","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0048105","count":5}]},{"hash":"922220629544240882","title":"Neural development and tissue remodeling","description":"The top GO terms cluster around neural development and function\u2014neuron migration, adult locomotory behavior, and synaptic transmission\u2014along with tissue remodeling processes such as organ regeneration and changes in cell-matrix adhesion. Growth factor signaling (PDGF) and related cellular responses can drive migration and remodeling in development and repair, which fits the overarching theme, even though a few terms touch immune-related processes. Overall, the cluster seems to represent neural development with accompanying tissue remodeling.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0001764","count":6},{"id":"GO:0030816","count":6},{"id":"GO:0008344","count":6},{"id":"GO:0031100","count":6},{"id":"GO:0001954","count":6}]},{"hash":"123258081687767038","title":"Ubiquitin-Proteasome Regulation of the Cell Cycle","description":"The top GO terms point to ubiquitination (K48, K11, K6 linkages), SCF- and APC/C-dependent proteolysis, and neddylation, all central to targeted protein degradation. This is tightly linked to cell cycle control (anaphase-promoting complex activity) and related quality-control pathways (ERAD). Peroxisomal import and viral process are supportive contexts, but the core theme is ubiquitin-mediated proteasomal degradation governing mitosis. ","confidence":"High","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070936","count":3},{"id":"GO:0070979","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0051301","count":3}]},{"hash":"1619726113005372826","title":"Microtubule organization and spindle orientation","description":"The GO terms point to a core theme of microtubule dynamics and spindle/centrosome orientation, including minus-end-directed sliding, microtubule cytoskeleton polarity, mitotic metaphase chromosome alignment, and meiotic spindle orientation. Additional terms like chloroplast movement and root development reflect broader cytoskeletal roles in plant development, while stress granule disassembly appears secondary. Overall, the cluster is best described by microtubule organization and spindle positioning.","confidence":"Medium","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035617","count":3},{"id":"GO:0031534","count":2},{"id":"GO:0032487","count":2},{"id":"GO:0007080","count":2},{"id":"GO:0072092","count":2}]},{"hash":"519139292477654903","title":"Proteostasis and Translation Initiation","description":"The proteins in this cluster show strong links to protein turnover (proteasome-dependent ubiquitin-mediated degradation, endopeptidase activity, deneddylation) and the initiation of protein synthesis (translation preinitiation complex formation, IRES-dependent initiation, regulation of translational initiation). While a few terms touch on mitochondrial dynamics and signaling, the dominant theme ties proteolysis to regulation of translation, suggesting a coordinated proteostasis/translational control module.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043161","count":3},{"id":"GO:0010950","count":3},{"id":"GO:0000266","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0048140","count":3}]},{"hash":"845847488301411682","title":"Synapse maturation and neurotransmission proteins","description":"The top GO terms center on synapse maturation, postsynaptic density assembly (gephyrin clustering), and neurotransmitter secretion/chemical synaptic transmission, with a few peripheral terms (wound healing, fibroblast migration) that are less central. Overall, the cluster appears to comprise proteins involved in synapse formation and neuronal communication.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0090126","count":3},{"id":"GO:0042060","count":3},{"id":"GO:0010762","count":3},{"id":"GO:0060122","count":3},{"id":"GO:1903553","count":3}]},{"hash":"1123534787271398483","title":"Autophagy- and proteolysis cluster","description":"This cluster is best characterized by strong signals for autophagy (GO:0006914), proteolysis (GO:0006508), and protein autoprocessing (GO:0016540), as well as negative regulation of APP biosynthetic processing (GO:0042985). Together these terms point to roles in intracellular protein turnover and maturation rather than a single tissue-specific pathway. Some peripheral terms reflect broader cellular stress responses (xenobiotic stimulus, lipopolysaccharide response, immobilization stress) that can engage autophagy, while other terms (drinking behavior, retinal pigment epithelium development, renin-angiotensin regulation) are more divergent annotations. Overall, the core theme is proteolytic processing and autophagy-related regulation of proteins. ","confidence":"Medium","size":6,"edges":6,"triangles":2,"max_degree":4,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0042985","count":5},{"id":"GO:0016540","count":5},{"id":"GO:0006914","count":5},{"id":"GO:0042756","count":5},{"id":"GO:0002016","count":5}]},{"hash":"1883199478277601571","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":6},{"id":"GO:0033092","count":6},{"id":"GO:0035050","count":5},{"id":"GO:0060841","count":5},{"id":"GO:0043305","count":5}]},{"hash":"1790285047770510135","title":"Neuronal development and synaptic function","description":"The top GO terms cluster around neural development and signaling: radial glia\u2013guided migration, dendrite extension, fast calcium-dependent neurotransmitter exocytosis, and modulation of synaptic plasticity, with supportive roles for GTPase regulation and vesicle trafficking. While some terms reflect broader cellular processes like ribophagy or membrane repair, the dominant neural-specific themes justify labeling the cluster as neuronal development and synaptic function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":3},{"id":"GO:0001778","count":3},{"id":"GO:1905171","count":2},{"id":"GO:0021814","count":2},{"id":"GO:0045943","count":2}]},{"hash":"405191926189585184","title":"Neural development and GPCR signaling with cytoskeletal remodeling","description":"The cluster tops include brain/forebrain/spinal cord development and signaling pathways linked to G proteins and PLC-activating GPCRs, plus actin filament depolymerization and heterotrimerization. This pattern points to neural development coordinated by GPCR signaling and cytoskeletal remodeling, with additional general cellular processes like ribosome maturation and ubiquitin ligase activity likely supporting these functions.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0007369","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0007200","count":2}]},{"hash":"597574805624466488","title":"Developmental signaling and apoptosis","description":"The top GO terms point to broad signaling regulation (kinase activity, glucocorticoid signaling, nuclear transport) coupled with mitochondrial apoptosis markers (cytochrome c release) and neural development processes (neuron migration, synaptic plasticity). This suggests a cluster centered on signaling pathways that govern development and stress-related cell fate decisions, despite some heterogeneity like keratinocyte development. Confidence: Medium","confidence":"","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1902309","count":5},{"id":"GO:1900740","count":5},{"id":"GO:0000079","count":5},{"id":"GO:0042921","count":5},{"id":"GO:0046827","count":5}]},{"hash":"1927615268054048404","title":"Cell Polarity and Vesicle Trafficking","description":"The GO terms point to processes governing how the cell organizes its membrane and directs vesicle traffic: establishment/maintenance of cell polarity, regulation of microvillus assembly, Golgi vesicle budding, and phospholipid translocation. These collectively reflect a shared theme of polarized membrane trafficking and structural organization, with some additional signals related to signaling or sensory responses that may be context-dependent. Overall, a coherent theme around polarity and membrane trafficking with moderate confidence.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"establishment or maintenance of cell polarity","top_go_terms":[{"id":"GO:0000749","count":4},{"id":"GO:0045579","count":4},{"id":"GO:0032534","count":4},{"id":"GO:0007163","count":4},{"id":"GO:0048194","count":4}]},{"hash":"777683360259550698","title":"Developmental Differentiation and Adhesion","description":"The terms cluster around tissue development and differentiation (lung development and epithelial differentiation, myelination in the PNS, muscle fiber-type transitions) and cell-cell adhesion, suggesting a developmental/morphogenesis theme. Some outliers (ascospore formation, adenosine biosynthesis, inflammatory regulation) may reflect annotation noise or cross-species differences, so confidence is moderate.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031573","count":6},{"id":"GO:0098609","count":6},{"id":"GO:0030437","count":6},{"id":"GO:0030324","count":6},{"id":"GO:0022011","count":6}]},{"hash":"814447582597965028","title":"Unknown","description":"The listed GO terms are scattered across sensory perception (pain and thermoception), neural differentiation (cerebellar granule cell differentiation), general growth processes (cell growth, angiogenesis), and various regulatory activities (PARP activity, transcription regulation, telomere binding). With no convergent function or pathway emerging from the terms, and with mostly single-term associations, there isn\u2019t a cohesive theme to define a specific, informative label. Therefore, the cluster is best described as Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":1},{"id":"GO:0035544","count":1},{"id":"GO:0050960","count":1},{"id":"GO:0021707","count":1},{"id":"GO:0016049","count":1}]},{"hash":"1817071548475971250","title":"RNA polymerase II transcription and chromatin regulation","description":"The top terms are centered on RNA polymerase II transcription, including elongation and preinitiation complex assembly, with supporting chromatin regulation terms (chromatin maintenance and histone acetylation regulation). This points to a cluster of transcription machinery functioning in a chromatin context, rather than a single downstream pathway.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007117","count":2},{"id":"GO:0070827","count":1},{"id":"GO:0001193","count":1},{"id":"GO:0060303","count":1},{"id":"GO:0006368","count":1}]},{"hash":"404988192990014041","title":"Neural Development and Brain Morphogenesis","description":"The top terms are dominated by neural development and brain formation processes, including pyramidal neuron development, brain morphogenesis, and Notch signaling, plus peripheral nervous system myelination, indicating a cohesive theme of neural differentiation and brain structure formation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0007219","count":2},{"id":"GO:0010036","count":1},{"id":"GO:0021860","count":1}]},{"hash":"2098237604147581712","title":"Ribosome biogenesis and rRNA maturation","description":"Most of the enriched terms describe maturation and assembly of ribosomal RNA and ribosomal subunits (SSU/LSU), i.e., ribosome biogenesis. A few terms touch on mRNA splicing and vesicle transport, but these are less representative. Thus, the cluster likely comprises proteins involved in ribosome assembly and rRNA processing.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0048568","count":3}]},{"hash":"554375579404254639","title":"RNA processing and translation regulation in stress granules","description":"This cluster centers on post-transcriptional RNA regulation: spliceosome-mediated mRNA splicing, splice site recognition, mRNA modification and stabilization, and related RNA metabolism, together with assembly of the translation initiation factor 4F complex and localization to cytoplasmic stress granules. The combination suggests a coordinated role in linking RNA processing to translation control under stress conditions.","confidence":"High","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5},{"id":"GO:1903608","count":3},{"id":"GO:1905663","count":3},{"id":"GO:0097010","count":3}]},{"hash":"2209048702821896550","title":"Translational control and protein homeostasis","description":"This cluster is driven by translation as a core function (GO:0006412) and includes terms related to regulating protein turnover (negative regulation of ubiquitin ligase activity and ubiquitin-dependent catabolic processes) and protein stability, with links to cell cycle regulation and p53-mediated signaling, indicating a theme around controlling protein synthesis, stability, and cell-cycle\u2013associated stress responses.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:1904667","count":1},{"id":"GO:0071157","count":1},{"id":"GO:0032986","count":1},{"id":"GO:0072717","count":1}]},{"hash":"860537275463596262","title":"Neural development and synaptic signaling","description":"The cluster is enriched for nervous system\u2013related terms, including cerebral cortex development, glomerulus development, glutamate receptor signaling, and chemical synaptic transmission, with calcium ion transport supporting neuronal signaling. While there are outliers like cell cycle regulation and acrosome reaction, the dominant pattern centers on neural development and synaptic communication, with bitter taste signaling also aligning with GPCR-mediated sensory signaling.","confidence":"Medium","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0040019","count":5},{"id":"GO:0021987","count":5},{"id":"GO:0006816","count":5},{"id":"GO:0000086","count":5},{"id":"GO:0050913","count":5}]},{"hash":"1165111532598675270","title":"Viral entry, assembly, and release","description":"The top GO terms cluster around viral processes: fusion of virus membrane with host plasma membrane (entry), virion assembly, and viral release from host cell, suggesting a cohesive theme of viral life-cycle steps despite some noisy, unrelated terms present. ","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":4},{"id":"GO:0045843","count":3},{"id":"GO:1901407","count":2},{"id":"GO:0019064","count":1},{"id":"GO:0010849","count":1}]},{"hash":"1192012025631999107","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0031247","count":4},{"id":"GO:0033574","count":4},{"id":"GO:0046295","count":4},{"id":"GO:0009103","count":4},{"id":"GO:0046839","count":4}]},{"hash":"493658148066428759","title":"Vertebrate Organogenesis","description":"The top GO terms point to development across multiple vertebrate tissues (forebrain, face, ureter, heart, Harderian gland), indicating a broad organogenesis program rather than a single pathway. While some metabolic terms appear, the strongest signal is embryonic organ development, supporting a label like Vertebrate Organogenesis.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035799","count":6},{"id":"GO:0030900","count":6},{"id":"GO:0070384","count":6},{"id":"GO:0048738","count":6},{"id":"GO:0015976","count":6}]},{"hash":"1338159081005732919","title":"Cytoskeletal dynamics and cell polarity","description":"The top GO terms cluster around actin remodeling and signaling that control cell shape and movement (actin filament branching; Cdc42 and Ras signal transduction), as well as processes tied to establishing and maintaining cell junctions and polarity (apical junction assembly; nuclear migration). These features are core to cytoskeletal organization and epithelial polarity, with additional terms related to organelle positioning (mitochondria distribution) and development, which are often driven by similar cytoskeletal and polarity mechanisms. Overall, the dominant theme points to cytoskeletal dynamics coordinating cell polarity and junctional organization, with some developmental processes piggybacking on these pathways.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007286","count":5},{"id":"GO:1903232","count":3},{"id":"GO:0071338","count":3},{"id":"GO:0043297","count":3},{"id":"GO:0007097","count":3}]},{"hash":"1379120765814061655","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006626","count":5},{"id":"GO:0006458","count":5},{"id":"GO:0009408","count":5},{"id":"GO:1900035","count":5},{"id":"GO:0030433","count":5}]},{"hash":"283670399701460055","title":"Nuclear Transport and Proteostasis","description":"This cluster\u2019s top GO terms cluster around nuclear processes: ubiquitin-dependent protein catabolic process points to proteostasis, and terms about nuclear import (NLS-bearing proteins imported into the nucleus) plus spindle organization emphasize nuclear functions during cell division. While a few terms touch signaling and metabolism, the strongest signal is regulation of nuclear proteins via turnover and transport.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006511","count":2},{"id":"GO:0007051","count":2},{"id":"GO:0043547","count":1},{"id":"GO:0000061","count":1},{"id":"GO:1901181","count":1}]},{"hash":"1741637070771898828","title":"Nuclear RNA Processing and Transcription Regulation","description":"The cluster shows clear enrichments for nuclear processes related to RNA synthesis and processing: transcription regulation by RNA polymerase II, mRNA splicing via spliceosome, and ribosomal subunit export from the nucleus, along with dephosphorylation as a regulatory step. Brain development and autophagy/xenobiotic responses appear as additional, less central themes, but the dominant signal centers on nuclear gene expression and RNA processing activities. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0000055","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0000398","count":2}]},{"hash":"2067827023611164646","title":"Diverse solute transmembrane transport","description":"The top GO terms indicate transport of a wide range of solutes across membranes (xenobiotics, vitamins, dehydroascorbic acid, nitrite, phosphate ions) and related transport activities, suggesting a cluster of membrane transporter proteins handling diverse substrates. Some entries relate to metabolism (fucose, lactose biosynthesis) but the dominant theme is transmembrane transport, supporting a label focused on solute transporters.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":6},{"id":"GO:0035461","count":6},{"id":"GO:1904728","count":4},{"id":"GO:0070837","count":4},{"id":"GO:0042891","count":4}]},{"hash":"2298601737522738392","title":"Unknown","description":"The top terms span DNA replication and transcription (nuclear processes) together with membrane transport, signaling, cytoskeletal organization, and bud neck localization, suggesting a highly heterogeneous set of functions rather than a single unifying role. There isn't a clear common theme tying all proteins together, so a specific functional label isn't justifiable.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0000733","count":2},{"id":"GO:0097271","count":1},{"id":"GO:0042391","count":1}]},{"hash":"1948278712078878748","title":"MVB-Mediated Protein Turnover and Trafficking","description":"Most of the GO terms converge on endosomal/MVB pathways and vacuolar sorting, including intralumenal vesicle formation and ubiquitin-dependent/independent protein catabolism via the MVB pathway, as well as related Golgi retention. While there are hints of membrane dynamics during the cell cycle and nuclear architecture, the dominant theme is vesicle trafficking to the vacuole and protein turnover through the MVB route, making this a coherent, specific label for the cluster.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031468","count":1},{"id":"GO:0007080","count":1},{"id":"GO:0043328","count":1},{"id":"GO:0045053","count":1},{"id":"GO:0006997","count":1}]},{"hash":"279712420299133988","title":"Unknown","description":"The top GO terms span a wide range of developmental and tissue-specific processes (heart, fat tissue, gonads, uterus, eye, habenula) and regulatory roles with no single unifying function. There isn\u2019t a cohesive biological theme linking these terms, so a specific functional label isn\u2019t apparent.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050728","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0043066","count":2},{"id":"GO:2000288","count":2},{"id":"GO:0060527","count":2}]},{"hash":"303547053828649807","title":"Embryonic organogenesis and tissue differentiation","description":"The top GO terms point to development and morphogenesis across multiple tissues (pancreas, kidney branching, lens proliferation, muscle differentiation, neural crest migration, digestive tract morphogenesis, etc.), with regulatory processes like transcriptional regulation also involved. This suggests a broad theme of embryonic organ development and differentiation across tissues, rather than a single, specific pathway. ","confidence":"Medium","size":6,"edges":8,"triangles":3,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":6},{"id":"GO:0048557","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0090190","count":4},{"id":"GO:2001111","count":4}]},{"hash":"2194102713261721691","title":"Fatty acid biosynthesis","description":"This cluster is dominated by GO terms for fatty acid biosynthesis, including long-chain fatty acid biosynthetic process, malonyl-CoA biosynthetic process, and general fatty acid biosynthetic process, with a few peroxisomal-related metabolism terms, suggesting a core function in fatty acid synthesis.","confidence":"High","size":6,"edges":12,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0044268","count":2},{"id":"GO:0042759","count":2},{"id":"GO:2001295","count":2},{"id":"GO:0006633","count":2}]},{"hash":"1995550031510976775","title":"Neuronal Synaptic Signaling and Plasticity","description":"The top GO terms cluster around neuronal communication and plasticity: neurotransmitter secretion, synaptic vesicle exocytosis, calcium signaling, dendrite extension, and long-term potentiation. A couple of terms touch on broader developmental processes, but the strongest signals are clearly related to synaptic function and neuronal growth.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903861","count":2},{"id":"GO:0060487","count":2},{"id":"GO:0030948","count":2},{"id":"GO:0032465","count":2},{"id":"GO:2000300","count":2}]},{"hash":"964916929160560506","title":"Glutamatergic Synaptic Transmission","description":"This cluster is dominated by terms tied to excitatory neurotransmission at glutamatergic synapses (EPSP, glutamatergic synaptic transmission, sodium ion transport), implying roles in excitatory signaling and ion channel activity. Other terms about optic nerve morphogenesis and drug responses seem incidental to the core glutamatergic signaling theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0097011","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0021631","count":3},{"id":"GO:0000186","count":3}]},{"hash":"1322691597455862303","title":"Sperm-Egg Recognition and Fusion","description":"Reasoning: the strongest signals are sperm-egg recognition, fusion of sperm to the egg membrane, and heterotypic cell-cell adhesion, which together point to fertilization and gamete interaction. Other terms (mitochondrial processes, TLR4 signaling, heart patterning) are present but do not override the fertilization theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034113","count":3},{"id":"GO:0007338","count":2},{"id":"GO:0035036","count":2},{"id":"GO:0007342","count":2},{"id":"GO:0002042","count":2}]},{"hash":"881059755554034531","title":"Lipid Biosynthesis and Myelin/Sebaceous Differentiation","description":"The cluster centers on lipid-related biosynthetic processes (unsaturated fatty acid biosynthesis, ergosterol biosynthetic regulation, MIPC sphingolipid metabolism) and lipid-rich tissue maintenance (myelin maintenance, sebaceous gland differentiation). These co-occuring terms suggest a cohesive theme around lipid metabolism and lipid-rich tissue maintenance, with supporting signals and stress responses (nitric oxide biosynthesis, nitrate assimilation, sulfur dioxide response) that can intersect with lipid pathways; mitochondrial inheritance may reflect energy/lipid dynamics. This yields a concise, representative label.","confidence":"Medium","size":6,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006809","count":6},{"id":"GO:0006636","count":6},{"id":"GO:0042128","count":6},{"id":"GO:0032286","count":6},{"id":"GO:0000001","count":6}]},{"hash":"848944295089778694","title":"Nucleotide Biosynthesis and Development","description":"This cluster is dominated by nucleotide metabolism terms (PRPP biosynthetic process, nucleoside metabolic process, AMP biosynthetic process, urate biosynthetic process) and related phosphorylation/regulation of catalytic activity, pointing to a core role in nucleotide production and turnover. The presence of development terms (nervous system development, bone development, animal organ regeneration) alongside metabolic terms suggests either multi-functional proteins or broad annotation but the central theme remains nucleotide metabolism. ","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006015","count":2},{"id":"GO:0031505","count":2},{"id":"GO:0031100","count":2},{"id":"GO:0034418","count":2},{"id":"GO:0009116","count":2}]},{"hash":"351717393836217440","title":"Developmental gene regulation","description":"The frequent GO terms cluster around developmental processes (forebrain development, neural tube closure, multicellular organism development, skeletal system development) and transcription (DNA-templated transcription), suggesting these proteins are involved in regulating gene expression during development. Some terms also reflect stress responses, but the core theme appears developmental and transcriptional, justifying a Developmental gene regulation label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030900","count":6},{"id":"GO:0006349","count":6},{"id":"GO:0071276","count":6},{"id":"GO:0001403","count":6},{"id":"GO:0050830","count":6}]},{"hash":"2088491407323307430","title":"Neurodevelopmental signaling and glial differentiation","description":"This cluster is dominated by terms tied to nervous system development and neural cell fate, including dendrite development, astrocyte differentiation, and BMP/PI3K signaling pathways, with supporting roles for cell adhesion/migration and receptor trafficking. While a couple of terms are broader developmental or signaling contexts, the strongest signals point to neural/glial differentiation and associated signaling networks.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032729","count":5},{"id":"GO:0019226","count":5},{"id":"GO:1902955","count":5},{"id":"GO:0001954","count":5},{"id":"GO:0043491","count":5}]},{"hash":"331298032854025121","title":"Antiviral innate immunity and autophagy","description":"The top GO terms point to an antiviral defense module: autophagy (GO:0006914), regulated NF-kappaB signaling (GO:0043123), and RIG-I\u2013mediated antiviral responses (GO:1900246, GO:0051092), along with negative control of IL-1 beta production (GO:0050713) and suppression of viral material transport. Taken together, these terms suggest proteins in this cluster collaborate to coordinate innate immune signaling with autophagic processes to limit viral replication.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:1901536","count":5},{"id":"GO:0050713","count":5},{"id":"GO:1901253","count":5},{"id":"GO:0045869","count":5}]},{"hash":"561671142035571947","title":"Ubiquitin-regulated autophagy in innate immunity","description":"The cluster centers on autophagy (GO:0006914) and ubiquitination (GO:0051865, GO:0085020) with explicit ties to innate immune response (GO:0045087) and stress signaling (regulation of JNK cascade, Rho signaling). This suggests a coherent theme where ubiquitin-mediated regulation intersects autophagy and innate immune signaling, despite some peripheral terms likely noise (e.g., tissue-specific branching). ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903762","count":2},{"id":"GO:1901253","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0035024","count":2}]},{"hash":"134277901251301074","title":"Brain and spinal cord development","description":"The strongest signals are brain development, forebrain development, and spinal cord development, suggesting a central theme of CNS formation. While some terms (DNA-templated transcription, actin depolymerization, growth hormone signaling) are broader, they can participate in developmental regulation, but do not override the CNS-focused pattern. Overall, the cluster appears tied to neural development and CNS patterning.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0007369","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1125357056311767456","title":"GTPase-regulated trafficking","description":"This cluster centers on GO terms like positive regulation of GTPase activity and endocytic recycling, pointing to control of small GTPase\u2013driven membrane trafficking as a core function. The presence of broad developmental terms (heart, brain regions, hair follicle, melanosome) suggests pleiotropy rather than a single tissue-specific role, so the label emphasizes the common trafficking/regulatory mechanism rather than a precise tissue function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0000060","count":5},{"id":"GO:0042176","count":5},{"id":"GO:0032456","count":5},{"id":"GO:0021762","count":5}]},{"hash":"1754395578741987149","title":"Ubiquitin-dependent proteostasis and innate immunity","description":"This cluster centers on ubiquitin-dependent protein catabolic processes and ER-associated degradation, with additional links to innate immune defense and viral response. Supporting terms include TORC1 signaling regulation, response to amino acid starvation, apoptosis, and microtubule localization, suggesting a coordinated role in proteostasis under stress that intersects immune signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0035372","count":3},{"id":"GO:0034198","count":3},{"id":"GO:0042787","count":3}]},{"hash":"1054852500391017593","title":"Regulators of erythrocyte and megakaryocyte differentiation","description":"Most terms point to hematopoietic lineage differentiation, especially erythrocyte and megakaryocyte differentiation (e.g., GO:0045654, GO:0045648). Other terms present are less directly connected (stress responses, cortical development, signaling), but the core theme is blood-cell lineage regulation. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045654","count":5},{"id":"GO:0010269","count":5},{"id":"GO:0010725","count":5},{"id":"GO:0060992","count":5},{"id":"GO:0021987","count":5}]},{"hash":"1324226542103698485","title":"Circadian transcription regulation","description":"This cluster centers on circadian rhythm control and transcription, evidenced by multiple terms for circadian regulation of gene expression and DNA-templated transcription, plus positive regulation of circadian rhythm. While other terms touch diverse processes, the strongest shared theme is circadian gene expression control.","confidence":"High","size":6,"edges":10,"triangles":7,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032922","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0042753","count":6},{"id":"GO:1905695","count":5},{"id":"GO:0070384","count":5}]},{"hash":"253848008701666935","title":"Cardiac conduction and atrial calcium signaling","description":"This cluster is dominated by GO terms tied to heart rhythm regulation and electrophysiology, including regulation of heart rate by cardiac conduction, membrane depolarization during AV node and His bundle APs, and regulation/repolarization of atrial cardiac muscle cell APs, plus calcium ion transport via high-voltage-gated calcium channels. These point to a cohesive theme of atrial/AV-node conduction and calcium-dependent action potential signaling in the heart. A couple of terms about mechanical sensation and thermoception are less related, but do not override the cardiac-focused pattern. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":5},{"id":"GO:0086091","count":5},{"id":"GO:0086045","count":5},{"id":"GO:0050966","count":5},{"id":"GO:0061577","count":5}]},{"hash":"713037095217823173","title":"Unknown","description":"The top terms are highly diverse (neural signaling regulation, muscle relaxation, GPCR/adenylate cyclase activity, immune differentiation, and even cell wall catabolic processes), with no clear shared function or pathway linking the proteins. The network shows no edges or triangles, supporting a lack of cohesive cluster biology, so no sensible specific label can be assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060160","count":2},{"id":"GO:0090075","count":2},{"id":"GO:0007194","count":2},{"id":"GO:0016998","count":2},{"id":"GO:0040015","count":2}]},{"hash":"1556219725557159813","title":"Cardiac conduction and action potential regulation","description":"This cluster is dominated by GO terms tied to heart rhythm and electrical activity (regulation of heart rate by cardiac conduction, regulation of ventricular and atrial action potentials, AV node depolarization). There are also notes on heart development (outflow tract morphogenesis) and calcium channel\u2013mediated calcium transport, which together point to cardiac electrophysiology and related development processes. A few terms (bone ossification, Wnt signaling) are less central but do not overwhelm the core cardiac theme.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903244","count":5},{"id":"GO:0086091","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0098911","count":5},{"id":"GO:0003151","count":4}]},{"hash":"49370625856900937","title":"Embryogenesis and neural morphogenesis","description":"The top GO terms cluster around embryonic development and neural patterning, including in utero embryonic development, neuron migration, and cortical layer formation, all pointing to early development and brain morphogenesis. While there are a few less central terms (ossification, N-myristoylation), the dominant signal is embryogenesis with neural morphogenesis. This supports a label of embryonic development and neural patterning in this cluster.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0001503","count":2},{"id":"GO:0010064","count":1},{"id":"GO:0018008","count":1}]},{"hash":"672627211660838457","title":"Muscle satellite cell activation and myoblast fusion","description":"The cluster shows strong signals for skeletal muscle development and repair, including myoblast fusion and satellite cell activation involved in skeletal muscle regeneration, with supportive hints from hypoxia response and general development processes; a few terms appear unrelated (pancreatic B cell apoptotic process, pain perception), but the dominant theme is muscle precursor activation and fusion.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097050","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0019233","count":2}]},{"hash":"1314134056170602133","title":"Mitochondrial Transport and Metabolic Regulation","description":"This cluster centers on membrane transport of multiple metabolites (glycine, NAD, thiamine pyrophosphate, citrate, thiosulfate) and mitochondrial processes (membrane fission, adaptive thermogenesis), with several terms tying into insulin signaling and glucose-stimulated responses. The combination suggests a theme of transport-linked energy metabolism and mitochondrial regulation, with insulin-responsive metabolic control as a common thread.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036233","count":6},{"id":"GO:0090149","count":6},{"id":"GO:0035352","count":6},{"id":"GO:0030974","count":6},{"id":"GO:1990845","count":6}]},{"hash":"2010550969870337342","title":"Acetylation and hexosamine metabolism","description":"The top GO terms show multiple acetylation-related processes (spermidine/spermine acetylation, N-terminal acetylation/propionylation, and related modifications) alongside sugar metabolism (glucosamine and N-acetylglucosamine pathways) and mycothiol biosynthesis, suggesting a cohesive theme around acetylation-driven regulation and sugar metabolism. Some outliers like subtelomeric heterochromatin formation and angiogenesis may reflect annotation noise or broader links, but the dominant pattern is acetylation-linked modification and related metabolic pathways.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":5},{"id":"GO:0032918","count":4},{"id":"GO:0061606","count":4},{"id":"GO:0032919","count":4},{"id":"GO:0006041","count":4}]},{"hash":"1568736238357103568","title":"Zinc Ion Transport and Homeostasis","description":"This cluster is dominated by GO terms related to zinc ion import, intracellular zinc ion homeostasis, detoxification, and metal transport, indicating a shared role in zinc handling. A couple terms (limb development, asparagine transport) are less clearly tied to zinc, but the zinc-related terms predominate, supporting a zinc homeostasis/transport theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":1},{"id":"GO:0006830","count":1},{"id":"GO:0006882","count":1},{"id":"GO:0044749","count":1},{"id":"GO:1903615","count":1}]},{"hash":"1697965059404764200","title":"Unknown","description":"The top terms cover a highly diverse set of functions, including immune defense, transcription, cell cycle, neural development, stress responses, and cell adhesion. There isn\u2019t a single coherent biological theme binding these proteins, so a meaningful, specific label isn\u2019t evident.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0030900","count":4},{"id":"GO:0071222","count":4}]},{"hash":"458920741749420962","title":"Retina development and vasculature","description":"This cluster's GO terms cluster around eye/retina biology, notably camera-type eye photoreceptor cell differentiation and retina vasculature development, with regulation of VEGF signaling supporting vascular growth. Additional terms on integrin signaling and microglia development suggest tissue organization and immune involvement in the retina. Overall, the set points to retinal development with a focus on photoreceptor maturation and vascularization.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":4},{"id":"GO:0014005","count":3},{"id":"GO:0071404","count":3},{"id":"GO:2000680","count":3},{"id":"GO:0043128","count":3}]},{"hash":"285921775042097580","title":"Unknown","description":"No GO terms are provided for this cluster, so there is no basis to identify a shared function or process among the proteins. Without functional terms or enrichment data, any label would be speculative. Therefore, this cluster is Unknown with no confidence.","confidence":"","size":6,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[]},{"hash":"1705954824664713540","title":"Developmental differentiation and morphogenesis","description":"This cluster's GO terms cluster around embryonic development and tissue morphogenesis, notably placental/trophoblast differentiation, left-right patterning, cartilage morphogenesis, and EMT in heart development. Supporting terms on transcriptional regulation during development align with this theme, making \"Developmental differentiation and morphogenesis\" a coherent, specific label for the group.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018003","count":2},{"id":"GO:0060707","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0032298","count":1},{"id":"GO:0000055","count":1}]},{"hash":"2161657567739915010","title":"VEGF-mediated neural-immune development signaling","description":"The cluster\u2019s GO terms span neural activity (nerve impulse transmission, axon regeneration), immune differentiation/regulation (dendritic cells, B cells, macrophages), and VEGF-related vascular signaling (endothelial cell chemotaxis, VEGF receptor signaling, VEGF-activated PDGF signaling). This suggests a shared theme of VEGF-centered signaling coordinating neural, immune, and developmental processes, hence the label focused on VEGF-mediated neural-immune development signaling.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":3},{"id":"GO:0038033","count":3},{"id":"GO:0060665","count":3},{"id":"GO:0042523","count":3},{"id":"GO:2001200","count":3}]},{"hash":"367745848498598991","title":"Ubiquitin-Proteasome Regulation of NF-\u03baB Signaling","description":"This cluster is dominated by GO terms related to ubiquitin-dependent protein catabolic processes, proteasomal degradation (including K48-linked ubiquitination), and regulation of NF-\u03baB and TNF signaling, with an additional note of B cell receptor signaling. The common thread appears to be regulation of protein turnover and inflammatory signaling pathways by ubiquitination, rather than a single metabolic or structural function. This suggests a cohesive group of ubiquitin-proteasome\u2013related regulators shaping immune signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0046676","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0051092","count":2}]},{"hash":"807910112672316869","title":"Proteostasis and ER stress regulation","description":"The cluster\u2019s GO terms repeatedly point to protein quality control and stress responses, especially ER stress, ER-associated degradation (ERAD), and protein deubiquitination, implying a shared role in maintaining proteostasis. While other terms touch on transcription regulation and DNA repair, the strongest signal is proteostasis/ER stress related processes.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097237","count":2},{"id":"GO:0006517","count":2},{"id":"GO:0033132","count":2},{"id":"GO:0006357","count":2},{"id":"GO:1902236","count":2}]},{"hash":"1042697152255964876","title":"TGF-beta/SMAD signaling in development","description":"These proteins appear linked to TGF-beta receptor signaling and SMAD-mediated transcription, supported by GO terms for SMAD complex assembly and phosphorylation, and DNA-templated transcription. Additional terms emphasize morphogenesis and boundary formation in the mesoderm (paraxial mesoderm, heart valve morphogenesis) and neural patterning (axon guidance, dorsal convergence). Collectively, the cluster seems to represent TGF-beta/SMAD-driven developmental signaling shaping mesodermal morphogenesis and related patterning.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007179","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0007183","count":4},{"id":"GO:0048859","count":3},{"id":"GO:0048340","count":3}]},{"hash":"312442662598910695","title":"Heart Development and Cardiac Electrophysiology","description":"The GO terms are dominated by cardiac-focused processes: outflow tract and left ventricular morphogenesis, multicellular heart development, and regulation of atrial and SA node action potentials, plus Purkinje signaling. While a few terms touch on skin and ossification, the strongest signal ties to heart formation and the cardiac conduction system, suggesting this cluster centers on cardiac development and electrical activity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0003151","count":5},{"id":"GO:0098910","count":5},{"id":"GO:0003220","count":5},{"id":"GO:0097050","count":5},{"id":"GO:0043588","count":5}]},{"hash":"220754702473016188","title":"Neural development and synaptic signaling","description":"The top GO terms are dominated by brain- and nervous system-related processes (substantia nigra development, visual perception) and synaptic organization (glycine receptor clustering), along with signaling modulation (negative regulation of protein kinase activity) and related cellular responses. Although there are some peripheral terms (molybdenum cofactor biosynthesis, muscle fiber development), the prominent theme is neural development and synaptic signaling, with supporting evidence from hypoxia response and gene expression regulation in neural contexts.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1085807919291277164","title":"Cardiac contraction and GPCR signaling","description":"The terms are dominated by cardiac-related functions (cardiac muscle contraction, heart development) and GPCR signaling pathways (acetylcholine and tachykinin receptor signaling, GPCR internalization) with supporting signaling regulators (peptidyl-threonine phosphorylation, Rac signaling). This suggests a cluster of proteins involved in cardiac muscle function and its GPCR-regulated signaling cascades, rather than metabolism or development of other tissues.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":2},{"id":"GO:0018107","count":2},{"id":"GO:0048538","count":2},{"id":"GO:0015758","count":2},{"id":"GO:0002031","count":2}]},{"hash":"13512569064189512","title":"Unknown","description":"The terms are a mix of chromatin modification and cell-cycle related processes (e.g., histone ubiquitination, transcription regulation during G2/M, DNA replication initiation) alongside several developmental morphogenesis terms and immunology-related processes. This broad spread suggests no single cohesive function tying all proteins together, making a clear interpretable label difficult. Therefore, Unknown with None confidence.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090055","count":2},{"id":"GO:0090282","count":2},{"id":"GO:0070535","count":2},{"id":"GO:0090419","count":2},{"id":"GO:1903468","count":2}]},{"hash":"1286327647516381889","title":"Extracellular Matrix Remodeling in Development","description":"The cluster is dominated by GO terms related to extracellular matrix degradation and remodeling (collagen catabolic process, basement membrane disassembly) and organ morphogenesis signals (lung branching), with supporting hints from bone resorption and proteolysis. Taken together, these terms point to matrix remodeling processes essential for developmental tissue patterning, though a few terms are tangential or broad.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035593","count":5},{"id":"GO:0045453","count":5},{"id":"GO:0050790","count":5},{"id":"GO:0030574","count":5},{"id":"GO:0060441","count":5}]},{"hash":"547393432987513507","title":"Bacterial energy metabolism and quinone biosynthesis","description":"Top terms indicate catabolic pathways for amino acids and fatty acids, glycolysis, and biosynthesis of quinones (menaquinone and phylloquinone), with a note of antibiotic biosynthesis. This points to a microbial metabolic module focused on energy production and cofactor biosynthesis, rather than a single isolated function. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":4},{"id":"GO:0010124","count":4},{"id":"GO:0006635","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0009234","count":4}]},{"hash":"491819236227509859","title":"ER stress response and protein folding","description":"The block\u2019s strongest signals are endoplasmic reticulum\u2013related: protein folding in the ER, response to unfolded proteins, and translation initiation regulation in response to ER stress, all hallmarks of the unfolded protein response and ER quality control. A few terms touch broader areas (innate immunity, mesoderm formation, hormone signaling), but the dominant theme centers on ER stress and protein folding.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046825","count":3},{"id":"GO:0006626","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0034975","count":2}]},{"hash":"1513849589092238361","title":"Neural development and synaptic signaling","description":"The GO terms point to nervous system\u2013related processes: dendrite extension, cortical neuron migration, calcium-dependent neurotransmitter release, and regulation of synaptic plasticity, plus ERBB2 signaling. While a few terms (angiogenesis, ribophagy) are broader, the dominant theme centers on neural development and synaptic function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0016525","count":5},{"id":"GO:1905171","count":3},{"id":"GO:0021814","count":3},{"id":"GO:0045943","count":3},{"id":"GO:0045945","count":3}]},{"hash":"1598808018542669835","title":"B cell activation and STAT signaling","description":"The top GO terms are dominated by immune-related processes, notably positive regulation of STAT tyrosine phosphorylation and immunoglobulin production, along with B cell apoptotic processes and TRAIL production, suggesting a core theme of B cell signaling and antibody-related activity. A few neural-related terms (paranodal junction assembly, regulation of oligodendrocyte differentiation) appear as secondary signals, which may reflect multi-function proteins or cluster noise but do not override the primary immune signature. Therefore, the cluster is best described as B cell activation and STAT signaling, with some potential neural context. ","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042511","count":2},{"id":"GO:0002377","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0030913","count":2},{"id":"GO:0048713","count":1}]},{"hash":"289579254030707437","title":"Neuronal signaling and neurodevelopment","description":"This cluster\u2019s terms cluster around nervous system function: response to acetylcholine, regulation of norepinephrine secretion, inhibitory postsynaptic potential, optic nerve morphogenesis, and calcium ion import across the membrane, all pointing to neurotransmission and neural development. Additional terms related to neural regulation of respiration and amyloid fibril formation further support a neural context, while a couple outliers (e.g., acrosome reaction) may reflect broader calcium- or signaling-related processes. Overall, the dominant theme is neural signaling and development.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1905920","count":5},{"id":"GO:0002087","count":5},{"id":"GO:0007340","count":5},{"id":"GO:1905144","count":5},{"id":"GO:0071294","count":5}]},{"hash":"1649884116172703407","title":"Unknown","description":"The GO terms are highly diverse (pollen sperm differentiation, tRNA and snoRNA processing, RNA phosphodiester bond hydrolysis, chromosome condensation, apoptosis in response to DNA damage, axonal fasciculation, and AMPA receptor clustering) with no clear shared biology or consistent protein interactions. This lack of a cohesive functional theme suggests no reliable single-label inference for the cluster.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048235","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0000294","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0034965","count":1}]},{"hash":"369851641999401235","title":"Ubiquitin-dependent proteostasis and ER stress","description":"The top GO terms cluster around ubiquitin-related processes (protein autoubiquitination and deubiquitination) and protein quality control, including deglycosylation and ER-associated degradation (ERAD), as well as ER stress\u2013related apoptosis regulation. Despite a few outliers (DNA repair and transcription regulation), the dominant theme is maintaining proteome integrity through ubiquitin cycling and ER quality control.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":3},{"id":"GO:0097237","count":2},{"id":"GO:0006517","count":2},{"id":"GO:0033132","count":2},{"id":"GO:0006357","count":2}]},{"hash":"1431868987523123787","title":"Unknown","description":"The Top Terms cover a mix of immune regulation, core nuclear processes (DNA replication, transcription, dephosphorylation, DNA damage signaling), cell adhesion, and diverse developmental contexts (fungal ascospore formation, lung development, myelination, fiber type switching). There is no single coherent pathway or function that ties these terms together, suggesting the proteins are functionally diverse or the annotations are broad; thus no specific, representative label can be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0016311","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0031573","count":1}]},{"hash":"2111302315968965143","title":"Budding Yeast Cytokinesis and Bud Neck Organization","description":"The top GO terms converge on cell cycle progression (mitotic cell cycle, DNA replication, cell cycle) and cytokinesis-related processes at the bud neck (protein localization to bud neck, septin ring assembly, division septum assembly) along with polarity maintenance, suggesting a cohesive module controlling budding-site\u2013directed cell division and cytoskeletal organization.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902857","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0097271","count":2},{"id":"GO:0030011","count":2}]},{"hash":"2163219477060000353","title":"Translation machinery and initiation complex","description":"The cluster is dominated by translation-related terms, especially translation (GO:0006412) and eukaryotic translation initiation factor 4F complex assembly (GO:0097010), indicating involvement in protein synthesis initiation and ribosome function. Some unrelated metabolic/transcription terms appear, but the strongest signal centers on translation machinery. ","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006729","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0051291","count":1},{"id":"GO:0043496","count":1}]},{"hash":"2173992535190860758","title":"T Cell Activation and Endosomal Trafficking","description":"The top GO terms show two clear themes: T cell\u2013related signaling and proliferation (T cell receptor signaling, positive regulation of alpha-beta T cell proliferation, interferon production) alongside multiple vesicle/trafficking processes (endosome to lysosome transport, early to late endosome transport, endosome to Golgi transport, Cvt pathway). This suggests a cluster centered on immune signaling coupled with intracellular endosomal trafficking pathways. Some mitotic cell cycle terms appear but are less representative of the main theme. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0032729","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0032258","count":2},{"id":"GO:0008333","count":2}]},{"hash":"559763214137352922","title":"Membrane Transporters","description":"The top GO terms are dominated by various transmembrane transport activities (nitrite, phosphate, sodium, xenobiotic, dehydroascorbic acid), indicating proteins that move substrates across membranes. Although a couple terms relate to carbohydrate metabolism, the prevailing signal is transporter function rather than a single metabolic pathway. ","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904728","count":4},{"id":"GO:0070837","count":4},{"id":"GO:0042891","count":4},{"id":"GO:0006004","count":4},{"id":"GO:0015707","count":4}]},{"hash":"608600656218713758","title":"Ribosome biogenesis and RNA transcription machinery","description":"Core terms cluster around ribosome biogenesis and translation, with multiple RNA polymerase I/II/III transcription processes, plus rRNA modification and snoRNP assembly. This points to a cohesive role in ribosome production and RNA processing.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0006360","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0042797","count":1}]},{"hash":"628532486586772470","title":"Embryonic Development and Growth","description":"The top GO terms cluster around embryogenesis and tissue development across multiple organs (embryonic organ development, seminiferous tubule/spinal cord/skin development) together with general growth and proliferation (multicellular organism growth, cell population proliferation, embryonic cleavage) and related cell cycle processes (mitotic sister chromatid cohesion). This suggests the proteins collectively participate in embryonic development and associated cellular proliferation, despite one obsolete aging term present. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072520","count":4},{"id":"GO:0021510","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0048568","count":4}]},{"hash":"97284534555907462","title":"Ribosome biogenesis and translation","description":"The cluster's GO terms are dominated by ribosome-related processes: cytoplasmic translation, ribosome biogenesis, and ribosomal large subunit assembly, plus SRP-dependent cotranslational targeting to membranes, indicating a shared involvement in ribosome function and protein synthesis. Other terms seem incidental.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":1},{"id":"GO:0071353","count":1},{"id":"GO:0006614","count":1},{"id":"GO:0032147","count":1},{"id":"GO:0002181","count":1}]},{"hash":"1743550259962096242","title":"Ribosome Biogenesis and Translation","description":"Top terms point to the ribosome and translation: cytosolic ribosome assembly (GO:0042256), rRNA maturation/processing (GO:0000462, GO:0006364), and translation-related processes (GO:0006412, GO:0045727, GO:0006354). This suggests proteins involved in ribosome biogenesis and the ribosome's translational activity. A few terms related to DNA damage response and gamma radiation are present but appear incidental and not central to the cluster.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000462","count":3},{"id":"GO:0031564","count":2},{"id":"GO:0071480","count":1},{"id":"GO:1902164","count":1}]},{"hash":"340173765042272281","title":"Chromatin Regulation and Transcription","description":"The strongest signals are DNA-templated transcription and histone methylation (H3K4 and H3K79), indicating chromatin modification as a core function. The presence of cell division and RNA cap methylation terms supports a transcriptional program tied to the cell cycle. Some terms also point to vesicle trafficking and proteostasis, suggesting additional, broader regulatory roles. Overall, the cluster is best described by chromatin-based transcriptional control with ancillary cellular processes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0034729","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006890","count":2}]},{"hash":"942725512792341704","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071383","count":2},{"id":"GO:0000154","count":1},{"id":"GO:0048254","count":1},{"id":"GO:0000244","count":1},{"id":"GO:0000447","count":1}]},{"hash":"1789402807591878848","title":"Germinal center and adaptive immune differentiation","description":"Top terms show a coherent theme around adaptive immune cell development and function, including germinal center formation, dendritic cell differentiation, pro-T cell differentiation, memory T cell differentiation, and isotype switching regulation. Some non-immune terms appear but are likely background noise; the dominant signal reflects B/T cell\u2013related differentiation and germinal center processes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002467","count":3},{"id":"GO:0042787","count":3},{"id":"GO:2001200","count":3},{"id":"GO:1900477","count":3},{"id":"GO:0072156","count":3}]},{"hash":"396251017374348095","title":"Ion transport and electrochemical gradient maintenance","description":"This cluster shows multiple GO terms tied to transmembrane ion transport and maintaining electrochemical gradients (monoatomic cation transport, potassium and sodium ion homeostasis, copper transport, and gradient establishment). These converge on membrane transport and potential regulation, suggesting the proteins function in ion transport rather than the other, more diverse terms that appear only peripherally (testosterone response, stilbene catabolism, lipopolysaccharide biosynthesis, fast-twitch muscle regulation). Overall, the ion transport/electrochemical gradient theme best represents the cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"establishment or maintenance of cell polarity","top_go_terms":[{"id":"GO:0099132","count":5},{"id":"GO:0033574","count":5},{"id":"GO:0009103","count":5},{"id":"GO:0046839","count":5},{"id":"GO:0031448","count":5}]},{"hash":"1702304270502914698","title":"Synaptic signaling and vesicle trafficking","description":"This cluster shows a theme around neuronal signaling and intracellular transport: terms for long-term potentiation/depression and excitatory postsynaptic potential indicate synaptic plasticity, while GO terms for small GTPase signaling and ER\u2013Golgi trafficking (Golgi ribbon formation, Golgi to vacuole transport) suggest coordinated trafficking related to synaptic function. Together, these functions imply proteins involved in modulating synaptic activity and vesicle/secretory pathway dynamics.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000251","count":2},{"id":"GO:0051660","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0007264","count":2}]},{"hash":"313493544859234961","title":"mRNA splicing and translation regulation","description":"The cluster's GO terms cluster around post-transcriptional RNA processing: regulation of mRNA splicing and spliceosome activity, mRNA modification and stabilization, and also assembly/regulation of the translation initiation machinery (eIF4F). This suggests a cohesive theme of coordinating mRNA maturation with initiation of translation.","confidence":"High","size":5,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1905663","count":2},{"id":"GO:0097010","count":2},{"id":"GO:0016556","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0048255","count":2}]},{"hash":"1174904392587872316","title":"Neuronal signaling and sensory processing","description":"The GO terms cluster around nervous system functions: GABA signaling, excitatory postsynaptic potentials, sensory perception of sound, locomotory behavior, conditioned taste aversion, and autonomic heart rate regulation, which together point to proteins involved in neuronal signaling and sensory processing. Ion transmembrane transport terms (sodium and potassium) support neuronal excitability. A defense response and an obsolete MAPK term appear incidental to the dominant neural theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":4},{"id":"GO:0042742","count":4},{"id":"GO:0050910","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0035725","count":3}]},{"hash":"1405937904892560919","title":"Spindle assembly and nuclear migration","description":"Top GO terms are dominated by microtubule- and spindle-related processes (minus-end directed microtubule sliding; establishment of meiotic spindle orientation; mitotic metaphase chromosome alignment and recapture; microtubule cytoskeleton polarity) and nuclear movements associated with conjugation/karyogamy, indicating a shared role in spindle assembly and nuclear relocation during cell division or mating. Some less direct terms related to development may reflect broader microtubule-dependent morphogenesis, but the dominant theme is spindle- and nuclear-directed processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031534","count":1},{"id":"GO:0032487","count":1},{"id":"GO:0000742","count":1},{"id":"GO:0007080","count":1},{"id":"GO:0000743","count":1}]},{"hash":"496579401870310450","title":"Dopaminergic GPCR Signaling Regulation","description":"The top GO terms are dominated by dopamine-related regulation: negative regulation of dopamine receptor signaling, dopamine transport, and an adenylate cyclase\u2013inhibiting GPCR signaling pathway, all pointing to modulation of dopaminergic neurotransmission via GPCRs and cAMP pathways. Some other terms touch xenobiotic response or growth, but they are less representative of the cluster\u2019s main theme. Overall, the cluster appears to center on neural dopaminergic signaling regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0060160","count":4},{"id":"GO:0090075","count":4},{"id":"GO:0007194","count":4},{"id":"GO:0016998","count":4}]},{"hash":"663967993528902753","title":"Epithelial polarity and tight junction assembly","description":"This cluster centers on establishment/maintenance of epithelial apical/basal polarity and bicellular tight junction assembly, with related apical protein localization and Golgi-to-plasma membrane transport. The liver/kidney development terms likely reflect tissue-specific contexts, but the core signal is epithelial polarity and junction formation.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045197","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0034379","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0045956","count":3}]},{"hash":"1411953242664223512","title":"Cytoskeleton Dynamics and Cell Polarity","description":"The top GO terms center on actin filament branching, Cdc42 and Ras signaling, apical junction assembly, and nuclear migration, all of which point to cytoskeletal remodeling and cell polarity. Other terms about mitochondrial distribution and intracellular transport also align with cytoskeleton-mediated trafficking, suggesting a cohesive theme around cellular architecture and signaling rather than a single specialized process.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903232","count":1},{"id":"GO:0071338","count":1},{"id":"GO:0043297","count":1},{"id":"GO:0007097","count":1},{"id":"GO:0046579","count":1}]},{"hash":"1927857189609860290","title":"Ubiquitin-Proteasome Proteolysis and Cytokinesis","description":"The cluster is dominated by GO terms for ubiquitin-dependent proteolysis (SCF-dependent, K48/K6 linkages) and proteasomal degradation, plus cell-cycle\u2013related processes like metaphase/anaphase transition and septin ring/bud neck localization, suggesting a cohesive role in ubiquitin-mediated protein turnover that governs cytokinesis and cell-cycle events.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0085020","count":3},{"id":"GO:0007250","count":3},{"id":"GO:0097271","count":3}]},{"hash":"897238597412030527","title":"Inflammatory Cytokine Production","description":"The top GO terms center on interleukin-4 and interleukin-23 production, inflammatory response, LPS response, and NF-kappaB signaling, plus nitric oxide biosynthesis, indicating an innate immune/inflammatory signaling module. Some terms related to development (forebrain, cardiac ventricle formation) are less directly connected and may reflect pleiotropy or annotation breadth, but the dominant theme is cytokine production and inflammatory signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072602","count":3},{"id":"GO:0032747","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0042346","count":2}]},{"hash":"1780608280313922119","title":"Meiotic DNA Repair and Chromosome Cohesion","description":"The cluster pulls together proteins involved in meiosis (female meiosis sister chromatid cohesion; meiosis I; synaptonemal complex assembly) with DNA damage response and repair mechanisms (double-strand break repair via synthesis-dependent strand annealing; cellular response to hydroxyurea/camptothecin/cisplatin; response to toxic substances), as well as apoptotic regulation, suggesting a coherent group focused on meiotic genome maintenance and damage-induced checkpoint responses.","confidence":"High","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0072711","count":2},{"id":"GO:0032508","count":2},{"id":"GO:0045003","count":2},{"id":"GO:0072757","count":2},{"id":"GO:0072719","count":2}]},{"hash":"758736796168989181","title":"Golgi vesicle trafficking and protein quality control","description":"Interpretation: The cluster highlights Golgi-related vesicle transport and protein quality control, including retention in the Golgi, vesicle formation, and ubiquitin-mediated regulation, with ties to stress responses (stress granule disassembly, inclusion body assembly) and DNA repair/transcription regulation under cellular stress.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000158","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0090261","count":2},{"id":"GO:0030420","count":2},{"id":"GO:0048219","count":2}]},{"hash":"1906751878059463092","title":"Regulation of transcription and cell differentiation","description":"Based on the top GO terms, this cluster centers on regulation of gene expression and differentiation across tissues, with transcriptional control and differentiation of lung epithelium and myoblasts, complemented by signaling pathway regulation (JNK, TGF-\u03b2/BMP) and related processes.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":4},{"id":"GO:0060487","count":3},{"id":"GO:0032465","count":3},{"id":"GO:0043547","count":3},{"id":"GO:2000009","count":3}]},{"hash":"1327500773373059318","title":"Hair Keratinization","description":"The cluster\u2019s top GO terms are hair cycle and keratinization, which together point to processes involved in hair follicle biology and keratin-based structural formation. This makes \u201cHair Keratinization\u201d a concise and representative label for the protein set.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":5},{"id":"GO:0031424","count":4}]},{"hash":"1236071633509847028","title":"Hair Keratinization Proteins","description":"The top GO terms are keratinization and hair cycle, indicating these proteins are involved in the structural keratinization process and hair follicle biology. The cluster broadly corresponds to keratin-related components active during hair growth, suggesting a coherent hair/epidermal differentiation function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":5},{"id":"GO:0042633","count":5}]},{"hash":"209812476690496553","title":"Embryonic Development and Signaling","description":"The terms cluster around embryonic development (gastrulation, forebrain and spinal cord development) and signaling activities (positive regulation of GTPase activity, GPCR signaling), with occasional mentions of translation initiation and cytoskeletal remodeling that accompany growth; the core theme is embryonic development coupled with signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0007369","count":1},{"id":"GO:0030900","count":1}]},{"hash":"2108428092142169530","title":"GPCR-cAMP Signaling in Stimulus Responses","description":"The terms cluster around G protein-coupled receptor signaling (including adenosine signaling and prostaglandin pathways) and downstream activation of protein kinase A, which ties into cAMP-mediated processes such as renal water homeostasis, urine volume regulation, and the acrosome reaction. Various environmental responses (ethanol, hypoxia) can intersect with GPCR signaling, supporting a common theme of receptor-mediated cellular responses to diverse stimuli.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0071380","count":5},{"id":"GO:0071361","count":5},{"id":"GO:1900194","count":4},{"id":"GO:0034199","count":4},{"id":"GO:0003091","count":4}]},{"hash":"824277709038657633","title":"Developmental signaling and immune regulation","description":"This cluster shows enrichment for developmental processes (nervous system and heart development) and signaling pathways (BMP and STAT) alongside immune-related activities (dendritic cell differentiation, neutrophil clearance, NK cell regulation) and cell adhesion, suggesting a theme of signaling-mediated development with immune modulation. A single outlier term on subtelomeric heterochromatin formation is less representative of the cluster\u2019s main function.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":2},{"id":"GO:0042523","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0030513","count":2}]},{"hash":"1498403920382848753","title":"Lipid metabolism and xenobiotic detoxification","description":"The set includes GO terms tied to lipid biology (positive regulation of phosphatidic acid biosynthetic process; triglyceride homeostasis; ketone metabolism) and detoxification (xenobiotic catabolic process), with circadian regulation of gene expression potentially modulating metabolism. Although a few terms relate to development or immune signaling, the core signals cluster around metabolic regulation of lipids and xenobiotic processing, suggesting these proteins function in metabolic and detox pathways.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1905695","count":5},{"id":"GO:0070384","count":5},{"id":"GO:0038097","count":5},{"id":"GO:0055012","count":5},{"id":"GO:0042738","count":5}]},{"hash":"446031314766524200","title":"Embryonic and tissue differentiation with transcriptional regulation","description":"The cluster includes GO terms for blood lineage differentiation (erythrocyte and granulocyte), early embryonic processes (primitive streak formation), and nervous system\u2013related development (PNS neurons, cerebral cortex, cochlea morphogenesis), plus transcriptional/epigenetic regulation (RNA Pol II regulation, miRNA transcription, histone deacetylation). This points to a broad theme of developmental differentiation across tissues, coordinated by transcriptional and epigenetic control.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045648","count":3},{"id":"GO:0090009","count":2},{"id":"GO:0048935","count":2},{"id":"GO:0070932","count":2},{"id":"GO:0000122","count":2}]},{"hash":"2204881086376921701","title":"Actin cytoskeleton remodeling and ubiquitin turnover","description":"The enriched GO terms point to actin dynamics, including Arp2/3-mediated actin nucleation and positive regulation of GTPase activity, suggesting a cytoskeleton remodeling theme. Concurrently, ubiquitin-dependent processes (ERAD, protein polyubiquitination, and ubiquitin-dependent catabolism) indicate a link to protein quality control and turnover. Some developmental or obsolete terms appear in the list but do not define the core cluster; the dominant signal is actin cytoskeleton regulation together with ubiquitin-mediated proteolysis. This combination suggests proteins involved in coordinating cytoskeletal remodeling with protein degradation pathways, rather than a single isolated function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0034314","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0007568","count":2}]},{"hash":"1925784759069754314","title":"Unknown","description":"There are no shared GO terms or interactions among the five proteins (Edges 0, Triangles 0, Max Degree 0), and the Top Terms list is empty. With no functional signal to tie the proteins together, I cannot assign a coherent function\u2014thus the appropriate label is Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"977249844134491866","title":"TNF/NF-\u03baB Signaling and Ubiquitination","description":"The cluster is dominated by GO terms linking ubiquitination (K6-linked ubiquitination; ubiquitin-dependent proteolysis) with NF-\u03baB pathway activation (IKK activation; I\u03baB phosphorylation) and TNF-mediated signaling, plus regulation of apoptosis, indicating a coherent module around TNF-induced NF-\u03baB signaling controlled by ubiquitin processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085020","count":5},{"id":"GO:0007250","count":5},{"id":"GO:0042787","count":5},{"id":"GO:1901253","count":5},{"id":"GO:2000620","count":5}]},{"hash":"1965042316343962884","title":"Developmental cell adhesion and signaling","description":"These terms cluster around receptor clustering and cell\u2013cell adhesion (heterophilic adhesion, hemidesmosome assembly) and various developmental morphogenesis processes (lung morphogenesis, axon guidance, astrocyte and muscle differentiation). Although some entries are tissue-specific, the common theme is intercellular signaling and adhesion guiding tissue development, hence the label Developmental cell adhesion and signaling.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":2},{"id":"GO:0060489","count":2},{"id":"GO:1904938","count":2},{"id":"GO:0014816","count":2},{"id":"GO:0014002","count":2}]},{"hash":"1681247705595405390","title":"Actin Cytoskeleton Remodeling and Cell Polarity","description":"Based on the top GO terms, the cluster centers on actin cytoskeleton dynamics and cell shape/polarity, with frequent mentions of establishment/maintenance of cell polarity, microspike assembly, actin cortical patch localization, and regulation of Rho signaling, plus mitotic actomyosin contractile ring assembly. While a few terms refer to signaling pathways (JUN phosphorylation, IL-2, endothelin, TGF-\u03b2), the dominant theme is cytoskeletal remodeling and polarized cell behavior.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071963","count":3},{"id":"GO:0030035","count":3},{"id":"GO:1900042","count":3},{"id":"GO:1903475","count":3},{"id":"GO:0051666","count":3}]},{"hash":"496028367737548567","title":"Embryogenesis and Neurodevelopment","description":"The top GO terms cluster around developmental processes, notably embryogenesis (primitive streak formation, multicellular organism development) and neural/eye development (forebrain and retina development), with supporting terms like cell division and actin filament remodeling that are common during morphogenesis. This suggests the proteins are enriched for roles in early development and neural differentiation rather to general housekeeping functions.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0030900","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0090009","count":2},{"id":"GO:0007338","count":2}]},{"hash":"247995840479852781","title":"Unknown","description":"The top GO terms span skeletal muscle development, immune cell differentiation (germinal centers, dendritic and pro-T cell differentiation, IgE isotype regulation), ubiquitin-dependent protein catabolism, distal tubule morphogenesis, and renal sodium absorption, with no single coherent biological process unifying them. This lack of a common function or pathway linking the set suggests the cluster cannot be confidently labeled with a specific, unified function.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":4},{"id":"GO:0002467","count":3},{"id":"GO:0042787","count":3},{"id":"GO:2001200","count":3},{"id":"GO:1900477","count":3}]},{"hash":"667870691506631650","title":"Neural development and sensory perception","description":"The top terms center on sensory stimulus detection (pain and thermoception) and cerebellar granule cell differentiation, suggesting a brain-related function with sensory processing and neural development. Additional terms like cell growth and protein modifications may reflect broader neuronal growth or regulation, but the core theme appears neural development coupled with sensory signaling. Confidence: Medium","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":2},{"id":"GO:0035544","count":2},{"id":"GO:0050960","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0016049","count":2}]},{"hash":"1584462247091512641","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":1},{"id":"GO:0001308","count":1},{"id":"GO:0016441","count":1},{"id":"GO:0034063","count":1},{"id":"GO:2000637","count":1}]},{"hash":"233833562426364908","title":"Developmental cell organization","description":"These proteins span developmental processes (imaginal disc-derived wing morphogenesis, spermatogenesis) and core cellular-architecture pathways (positive regulation of non-motile cilium assembly, spindle orientation, ER-to-Golgi vesicle transport, autophagy, transcription). The common thread is coordination of cellular structure and organization during development, despite the diversity of specific GO terms.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902857","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0007476","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0006914","count":1}]},{"hash":"861984714584129182","title":"Reproductive development and TGF-\u03b2 signaling","description":"The top GO terms point to developmental processes in reproductive tissues (digestive tract development, uterus development, female gonad development) and signaling via the TGF-\u03b2 pathway (TGF-\u03b2 receptor signaling, SMAD complex assembly). While there are also general intracellular trafficking terms (Golgi/lysosome related), the shared theme appears to be reproductive organ development driven by TGF-\u03b2 signaling. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048565","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0008585","count":2},{"id":"GO:0007179","count":1},{"id":"GO:0045053","count":1}]},{"hash":"1128641767156746619","title":"Embryonic Development and Organ Morphogenesis","description":"The top GO terms point to developmental and morphogenetic processes across multiple tissues, including placental differentiation, left/right pattern formation, EMT in heart development, cartilage morphogenesis, endocrine organ development, and endothelial migration. These collectively suggest a theme of embryonic organogenesis and tissue differentiation, despite some lineage-specific terms, making this a cohesive cluster for development/morphogenesis.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0003198","count":3}]},{"hash":"2009893256972394001","title":"Neuromuscular development and muscle movement","description":"The top terms highlight somatic motor neuron differentiation, neuromuscular movement, and neurofilament cytoskeleton organization, suggesting a cohesive role in neuromuscular development and motor function. Translations and collagen biosynthesis appear as incidental terms reflecting general cellular processes rather than the core theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046898","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0050884","count":1},{"id":"GO:0021523","count":1}]},{"hash":"183979189515802476","title":"Neuro-immune-vascular signaling regulators","description":"The set of GO terms points to regulators of signaling across several systems: neural (transmission of nerve impulse, heart rate regulation), immune (dendritic cell differentiation, IL-4 production, macrophage activation), and vascular/epithelial interactions (VEGF-driven endothelial chemotaxis, cell adhesion). The common theme is modulation of intercellular signaling and communication among nervous, immune, and vascular contexts, with some developmental/adhesive processes also linked. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0086091","count":4},{"id":"GO:0019226","count":4},{"id":"GO:0038033","count":4},{"id":"GO:0060665","count":4},{"id":"GO:0002860","count":4}]},{"hash":"1433438541264303125","title":"Spliceosome assembly and RNA processing","description":"This cluster is dominated by RNA processing and splicing functions, including spliceosomal snRNP and complex assembly, mRNA splicing via the spliceosome, and broader RNA maturation processes (tRNA processing, rRNA maturation, histone mRNA metabolism), suggesting a core spliceosome/RNA processing module.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":3},{"id":"GO:1990141","count":3},{"id":"GO:0008033","count":3},{"id":"GO:0000387","count":3},{"id":"GO:0030490","count":3}]},{"hash":"1966712973226147361","title":"Unknown","description":"The top GO terms span diverse and largely unrelated biological areas (fungal ascospore formation, neural and cardiac development, cone photoresponse recovery, nuclear import, calcium signaling, germ cell proliferation, and adrenergic response), with no clear common function tying the proteins together.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030437","count":3},{"id":"GO:0048708","count":3},{"id":"GO:0003151","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0060048","count":3}]},{"hash":"1782983889801534203","title":"DNA-Templated Transcription Regulation and miRNA Processing","description":"The cluster centers on transcription-related processes (DNA-templated transcription, termination regulation, and transcription antitermination) and RNA handling (pre-miRNA processing, miRNA catabolic process, mRNA stabilization), suggesting a cohesive theme of transcription control coupled with microRNA maturation and turnover; some terms about kidney development and osmotic stress appear but are less central.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0070934","count":4},{"id":"GO:0060567","count":4},{"id":"GO:0031054","count":4},{"id":"GO:0031564","count":4}]},{"hash":"101829091354278829","title":"Immune receptor signaling and ubiquitin regulation","description":"Top terms center on immune receptor signaling (T cell receptor and C-type lectin receptor pathways) and inflammatory signaling (TNF-mediated), with an additional cue for ubiquitin-related regulation (deubiquitination). This combination points to a cluster focused on immune signaling and post-translational control, though some terms are tangential. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0061418","count":1},{"id":"GO:0002223","count":1},{"id":"GO:0016579","count":1}]},{"hash":"507952626157605247","title":"Tissue Development and Differentiation","description":"Top terms emphasize development and differentiation across several tissues\u2014skin, skeletal system, and prostate gland development\u2014as well as multicellular organism development. Some terms indicate environmental or regulatory contexts (vitamin D response, hypoxia) that can modulate developmental programs. Because the terms point to broad developmental processes rather than a single pathway, the cluster is best described as Tissue Development and Differentiation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031915","count":2},{"id":"GO:0060528","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0051260","count":2}]},{"hash":"749483740082744635","title":"Meristem Identity Signaling Regulation","description":"The GO terms cluster around developmental signaling and regulation of growth-factor\u2013related pathways, including maintenance of meristem identity and regulation of TGF-beta/BMP signaling. This points to a set of proteins that modulate signaling cascades in development (especially meristem-related) rather than performing a single enzymatic action. Confidence: Medium","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000173","count":4},{"id":"GO:0071560","count":4},{"id":"GO:0042006","count":4},{"id":"GO:0030514","count":4},{"id":"GO:0061191","count":4}]},{"hash":"25660493423524000","title":"Chromatin assembly and DNA replication","description":"The strongest signals are centromeric chromatin assembly (CENP-A) and establishment of protein localization to chromatin, plus DNA replication, which together point to a nuclear chromatin maintenance/duplication theme. ER-related terms appear but are less central, so the core label emphasizes chromatin-related functions. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030970","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0070389","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0061641","count":2}]},{"hash":"2048863912330729126","title":"DNA Repair and Damage Response","description":"The top GO terms point to DNA damage repair processes (nucleotide-excision repair, SDSA) and cellular responses to replication stress and DNA-damaging agents (hydroxyurea, camptothecin, cisplatin, pyrimidine dimer repair), indicating genome maintenance as the cluster's core function. The translation term likely reflects co-occurring ribosomal proteins present in the cluster rather than a primary function.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0032508","count":2},{"id":"GO:0072711","count":2},{"id":"GO:0045003","count":2},{"id":"GO:0072757","count":2}]},{"hash":"558908462663641516","title":"Ubiquitin-mediated degradation and autophagy","description":"This cluster centers on protein turnover and quality control, with multiple terms for ubiquitin-dependent proteolysis and autophagy (including autophagy of mitochondrion and the Cvt pathway) and related protein modification (ufmylation). The cadmium response further supports a stress-related proteostasis role, making a cohesive theme around proteolysis and cellular cleaning under stress.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0045892","count":1},{"id":"GO:0051726","count":1},{"id":"GO:0018192","count":1}]},{"hash":"1311786005535154807","title":"Unknown","description":"The GO terms span lipid biosynthesis, amino acid metabolism, methionine cycle, sporulation, photosynthetic carbon pathway, and general nutrient response, with no single pathway or shared process tying them together. The lack of edges and low connectivity further suggests these annotations do not define a cohesive functional module.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006656","count":2},{"id":"GO:0061179","count":2},{"id":"GO:0033353","count":1},{"id":"GO:0030435","count":1},{"id":"GO:0009097","count":1}]},{"hash":"978370280734975564","title":"Unknown","description":"This cluster lacks edges and has a scattered mix of GO terms (including obsolete entries) with no clear shared function. Without a consistent biological theme among the proteins, a meaningful label cannot be inferred.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019556","count":1},{"id":"GO:0019557","count":1},{"id":"GO:0035955","count":1},{"id":"GO:0007091","count":1},{"id":"GO:0072189","count":1}]},{"hash":"1710047975501483348","title":"B cell receptor and Fc receptor signaling","description":"These proteins cluster around adaptive immune signaling, especially pathways tied to B cell receptor signaling and Fc\u03b5 receptor signaling, with cytokine regulation (IL-2/IL-3) and KIT-related signaling. The GO terms strongly point to B cell activation and antibody receptor\u2013mediated signaling, with related modulation of other immune pathways and angiogenesis in immune contexts. This supports labeling the cluster as a B cell receptor and Fc receptor signaling module.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":4},{"id":"GO:1900042","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0045401","count":3}]},{"hash":"79948634987117745","title":"Immune cell differentiation and cytokine signaling","description":"This cluster is dominated by GO terms related to immune system development and cytokine pathways, including positive regulation of dendritic cell and B cell differentiation, positive regulation of cytokine production, and STAT signaling. These together suggest a core theme of immune cell development and cytokine-mediated signaling, with supporting terms touching wound healing and endothelial morphogenesis that may reflect broader inflammatory contexts.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042523","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0001923","count":2},{"id":"GO:0030513","count":2},{"id":"GO:1904597","count":2}]},{"hash":"2016981114910748299","title":"Neural development and sensory organ formation","description":"The top GO terms indicate neural development (neuron projection development, neuron migration, transmission of nerve impulse) and sensory-structure formation (lens fiber differentiation, olfactory placode morphogenesis). The inclusion of regulation of Rho signaling suggests cytoskeletal changes underlying neurite outgrowth and neuronal migration. Although some terms touch broader developmental processes, the dominant pattern points to nervous system and sensory organ formation, justifying this label.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0001501","count":3}]},{"hash":"2253690625581419133","title":"Developmental Signaling Network","description":"The terms point to broad developmental processes (multicellular organism development, forebrain development) and a range of signaling pathway regulations (NF-kappaB, ERK cascade, estrogen receptor signaling, PDGF and LDL-related responses). This suggests a general theme of signaling involved in development rather than a single specific function, hence a developmental signaling cluster with immune-related differentiation aspects.","confidence":"Low","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0007275","count":2},{"id":"GO:1990859","count":1},{"id":"GO:0030900","count":1},{"id":"GO:0045579","count":1}]},{"hash":"2204456016230338831","title":"Leukocyte activation and immune communication","description":"The top GO terms point to leukocyte signaling and intercellular interaction (NK cell cytotoxicity regulation, dendritic cell differentiation, IL-4 production, macrophage activation modulation, humoral immunity, neutrophil degranulation, cell recognition, and cell adhesion), indicating a theme of immune cell activation and communication. An outlier term for bitter taste detection may reflect shared receptors in some immune cells, but the dominant pattern is leukocyte coordination and immune response.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002860","count":1},{"id":"GO:2001200","count":1},{"id":"GO:0045404","count":1},{"id":"GO:0043031","count":1},{"id":"GO:0008037","count":1}]},{"hash":"1680953442490749379","title":"Ubiquitin-Proteasome\u2013Mediated Cell Cycle Regulation","description":"The top GO terms cluster around ubiquitin-dependent proteolysis (SCF-dependent ubiquitin ligase activity and general ubiquitin-dependent catabolic process) and mitotic/cell-cycle processes (G1 DNA damage checkpoint signaling, spindle assembly in meiosis). This points to a cohesive theme of proteasome-driven control of the cell cycle, with supporting links to chromatin and transcription regulation during G1/S. A few terms related to stress responses (cadmium, neuronal apoptotic signaling) appear but do not dominate. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031571","count":3},{"id":"GO:0000083","count":3},{"id":"GO:0051436","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0071276","count":3}]},{"hash":"446750608774881718","title":"Unknown","description":"The top GO terms are diverse and cover unrelated processes (retinol/retinal metabolism, poly-hydroxybutyrate biosynthesis, sporulation, lung development, hormone biosynthesis, etc.), with no clear shared function tying the four proteins together. Confidence: None","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042619","count":2},{"id":"GO:0042574","count":2},{"id":"GO:0042572","count":2},{"id":"GO:0031427","count":1}]},{"hash":"439074961598848774","title":"Immune cell recruitment and adhesion","description":"The enrichment centers on immune cell movement (dendritic cell and B cell chemotaxis), macrophage cytokine production, and cell-cell adhesion, suggesting a module focused on immune cell trafficking and interaction. Some apoptosis and coagulation-related terms appear but overall the theme is immune recruitment and communication.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030195","count":2},{"id":"GO:2000270","count":2},{"id":"GO:0033159","count":2},{"id":"GO:0072137","count":2},{"id":"GO:0007157","count":2}]},{"hash":"1958639872380919612","title":"Pentose phosphate pathway components","description":"The top GO terms show explicit links to pentose phosphate shunt and pentose catabolic processes, suggesting the proteins are involved in pentose metabolism. Some other terms appear obsolete or unrelated, indicating noise, but the PPP-related terms provide the main thematic signal. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0035551","count":1},{"id":"GO:0034396","count":1},{"id":"GO:0034724","count":1}]},{"hash":"642260686515872620","title":"Ubiquitin-regulated ER-Golgi protein processing","description":"This cluster centers on GO terms involving regulation of ubiquitin-specific protease activity, ER-to-Golgi vesicle transport, and Golgi-associated protein processing, with an additional oxidative stress response signal. The combination suggests a coordinated role in protein quality control and trafficking through the secretory pathway under stress conditions, despite some terms being less directly connected. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000158","count":3},{"id":"GO:0034599","count":3},{"id":"GO:1903007","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0070414","count":3}]},{"hash":"1561455326774408965","title":"Actin-Driven Endocytosis and Signaling","description":"The terms emphasize actin cytoskeleton remodeling (actin filament branching, ruffle and podosome assembly, cell polarity) paired with endocytosis and receptor signaling (T cell receptor and ephrin pathways), suggesting proteins coordinate membrane trafficking with actin dynamics to modulate cell shape, adhesion, and immune signaling.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0090135","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0070830","count":3}]},{"hash":"1282111278560955541","title":"Actin Cytoskeleton Organization and Centrosome Localization","description":"Based on the top GO terms, the proteins cluster around actin cytoskeleton dynamics (actin filament polymerization and actin cytoskeleton organization) and centrosome localization, with related regulation of cell shape. This suggests a cohesive role in organizing actin structures and positioning the centrosome, rather than a single metabolic pathway; some broader terms may reflect multifunctionality but do not override the dominant cytoskeletal theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":2},{"id":"GO:0051660","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0006695","count":1}]},{"hash":"476721680015400625","title":"Ion transport and metal ion homeostasis","description":"The top GO terms are dominated by transmembrane transport of ions and small charged molecules (monoatomic cation, proton, potassium, manganese, and polyamine transport) and manganese ion homeostasis, suggesting a cluster centered on membrane transport and metal ion regulation. A few outliers related to signaling or autophagy are present, but the core theme remains ion transport/homeostasis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000749","count":1},{"id":"GO:0099132","count":1},{"id":"GO:1905122","count":1},{"id":"GO:1903249","count":1},{"id":"GO:0030026","count":1}]},{"hash":"1648339853862461375","title":"Growth factor signaling and cytoskeleton remodeling","description":"The cluster is enriched for terms tied to receptor tyrosine kinase signaling (e.g., collagen-activated pathways, VEGF receptor signaling, HGF response) that drive actin cytoskeleton reorganization and cell migration (cortical actin organization, fibroblast migration). This points to a cohesive theme of growth factor\u2013mediated signaling leading to cytoskeletal dynamics and movement. Some terms (forebrain development, certain differentiation processes) are less directly connected, likely reflecting pleiotropy, but the dominant signal is signaling-cytoskeleton remodeling.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010571","count":3},{"id":"GO:0007098","count":3},{"id":"GO:0030900","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0002333","count":2}]},{"hash":"1391555052458555582","title":"Stress-Responsive RNA Processing and Translation","description":"The Top Terms point to post-transcriptional regulation: translation initiation via the eIF4F complex, mRNA modification and splicing, and mRNA stabilization, alongside cellular stress responses (ischemia, hypoxia). This suggests a coherent cluster of proteins involved in managing gene expression at the RNA level under stress. Some terms related to telomere maintenance and insulin signaling appear less connected and may reflect broader signaling links or annotation noise, but the core theme remains RNA processing and translation control under stress.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1905663","count":2},{"id":"GO:0097010","count":2},{"id":"GO:0002931","count":2},{"id":"GO:0016556","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1757971096151070607","title":"Unknown","description":"The GO terms span very different biological contexts (nuclear import, ascospore formation, astrocyte differentiation, cardiac and skeletal muscle processes, myelination, calcium channel regulation, germ cell proliferation, NF-kappaB signaling) with no unifying function or pathway. With edges and connections absent, there isn\u2019t a cohesive theme to anchor a specific label, so Unknown is most appropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":2},{"id":"GO:0030437","count":1},{"id":"GO:0048708","count":1},{"id":"GO:0060048","count":1},{"id":"GO:0022011","count":1}]},{"hash":"433913481210028378","title":"Actin-driven neuronal dendrite development and synaptic plasticity","description":"This cluster centers on actin cytoskeleton dynamics, with terms for actin nucleation and filament formation, Rac signaling, and neuronal dendrite development and synaptic plasticity, suggesting a shared role in shaping neuronal morphology and synaptic function. Some terms reference endothelial tight junctions, but the core signal is neural actin remodeling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":2},{"id":"GO:0061028","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0090140","count":2}]},{"hash":"800156068522462750","title":"RNA processing and mRNA export","description":"The top GO terms cluster around RNA metabolism: helicase activity and ATP-dependent activity suggest RNA remodeling, while poly(A)+ mRNA export from the nucleus directly points to the export pathway. Together, these indicate a cohesive role in RNA processing and nucleus-to-cytoplasm mRNA transport. The stem cell maintenance term is less clearly connected, so the core theme remains RNA processing/export.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902455","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0016973","count":1}]},{"hash":"1518057384005444817","title":"RNA processing and translation regulation","description":"The top GO terms cluster around mRNA splicing (spliceosome), mRNA modification and stabilization, and regulation of translational initiation, with an additional term tied to assembly of the eIF4F complex. This points to coordinated RNA processing and control of translation as the shared function of these proteins.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905663","count":2},{"id":"GO:0097010","count":2},{"id":"GO:0016556","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0048255","count":2}]},{"hash":"828346610361105915","title":"Translation initiation and mRNA processing","description":"Dominated by translation initiation terms (formation of translation preinitiation complex; eukaryotic translation initiation factor 4F complex assembly; translation reinitiation) and supported by RNA processing and mRNA metabolism terms (mRNA modification; mRNA splicing, splice site recognition; mRNA stabilization). ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:1905663","count":1},{"id":"GO:0097010","count":1},{"id":"GO:0016556","count":1}]},{"hash":"627194679507107432","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0060487","count":2},{"id":"GO:0032465","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0045944","count":2}]},{"hash":"1747395170771045884","title":"Membrane Ion Transport","description":"The top terms include monoatomic cation transmembrane transport, proton transmembrane transport, and potassium ion import, which strongly point to ion movement across membranes. Some terms are tangential, but the dominant theme across the terms is membrane ion transport.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0099132","count":3},{"id":"GO:1903249","count":3},{"id":"GO:0033574","count":3},{"id":"GO:0015991","count":3},{"id":"GO:1990573","count":3}]},{"hash":"1350628483605168429","title":"Cardiac conduction and HV calcium channel signaling","description":"The GO terms point to heart electrical activity, including regulation of heart rate by cardiac conduction, membrane depolarization during AV node and bundle of His cell action potentials, and calcium ion transport via high voltage-gated calcium channels. While a few terms relate to morphology or other tissues, the core cluster centers on cardiac electrophysiology and calcium signaling, justifying a label focused on cardiac conduction and HV calcium channels.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050804","count":1},{"id":"GO:0003151","count":1},{"id":"GO:0086091","count":1},{"id":"GO:0086045","count":1},{"id":"GO:0050966","count":1}]},{"hash":"905155429865886680","title":"Cardiac electrophysiology and heart development","description":"The cluster shows GO terms centered on cardiac electrical activity and development\u2014regulation of heart rate by cardiac conduction, AV node/His bundle action potential depolarization, atrial action potentials, and HV calcium channel transport\u2014with outflow tract morphogenesis also represented. A few terms about pain/temperature appear less connected.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0003151","count":3},{"id":"GO:0086091","count":3}]},{"hash":"261894654933845451","title":"Cartilage Proteoglycan Biosynthesis","description":"This cluster centers on cartilage formation and extracellular matrix assembly, with terms for endochondral ossification, cartilage development, and proteoglycan biosynthesis of chondroitin/dermatan sulfate. Sulfation and UDP-glucuronate metabolism further support glycosaminoglycan production, while semicircular canal formation and Smoothened signaling link to skeletal and cartilage-related patterning. Overall, the proteins likely participate in cartilage ECM biosynthesis and maturation.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":2},{"id":"GO:0050650","count":1},{"id":"GO:0045880","count":1},{"id":"GO:0050653","count":1},{"id":"GO:0051923","count":1}]},{"hash":"1316993740019280858","title":"Regulation of synaptic vesicle cycling","description":"The top GO terms point to regulation of synaptic vesicle endocytosis and exocytosis, plus an excitatory postsynaptic potential, indicating a shared role in vesicle cycling at neuronal synapses. Several other terms (nucleolus localization, xenobiotic response, ossification, hair follicle proliferation, substantia nigra development, mitosis) appear ancillary or incidental, but the core signal is clearly presynaptic vesicle regulation. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":2},{"id":"GO:1902570","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0021762","count":2}]},{"hash":"492801694880244438","title":"Unknown","description":"The top GO terms are extremely diverse, including plant-specific processes (photosynthesis, chlorophyll biosynthesis, photoreceptor outer segment localization) and unrelated animal processes (muscle contraction, male sex differentiation, fat pad development), with only single-term annotations. There is no coherent shared function or pathway linking these terms, suggesting no clear common theme for the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097237","count":1},{"id":"GO:0046661","count":1},{"id":"GO:0006939","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0015979","count":1}]},{"hash":"1059884824714581277","title":"Neurodevelopment and Neuronal Migration","description":"The top GO terms cluster around neural development and neuron migration\u2014neuroblast proliferation regulation, nerve branching morphogenesis, and tangential migration to the olfactory bulb\u2014supported by Wnt signaling and neuronal organelle distribution (Golgi localization, mitochondria distribution). A neural survival context is also hinted by ER stress\u2013related apoptotic signaling regulation, making a neural development/migration theme most coherent despite one outlier term.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":1},{"id":"GO:0022028","count":1},{"id":"GO:1904887","count":1},{"id":"GO:1902692","count":1},{"id":"GO:0051683","count":1}]},{"hash":"1848213369770212371","title":"Unknown","description":"Top terms span diverse processes (cell cycle, plasmid partitioning/conjugation, LPS biosynthesis, stress responses, and ER membrane protein insertion) with no single cohesive function, so there is no clear shared theme for the cluster. ","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0099132","count":1},{"id":"GO:0030541","count":1},{"id":"GO:0018108","count":1},{"id":"GO:0009103","count":1}]},{"hash":"570885145542711228","title":"Rac-dependent actin remodeling and endocytosis","description":"These GO terms cohere around actin cytoskeleton dynamics (actin filament branching, ruffle/podosome assembly), Rac and small GTPase signaling, cell polarity, and endocytosis/engulfment. Together they point to Rac-mediated cytoskeletal remodeling that drives membrane protrusions and uptake processes, so the label reflects the cluster\u2019s likely function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090135","count":2},{"id":"GO:0071803","count":2},{"id":"GO:0034260","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0016601","count":2}]},{"hash":"2156793342747269915","title":"Bacterial lipid metabolism and envelope biosynthesis","description":"The GO terms cluster around fatty acid import and biosynthesis, lipoteichoic acid biosynthesis, and menaquinone biosynthesis, plus related acetyl-CoA, propionate, and carnitine metabolism. This points to lipid metabolism and cell envelope assembly typical of bacteria (especially Gram-positive via lipoteichoic acid). Some terms like bioluminescence or seed germination seem unrelated or noisy. Overall, a cohesive theme is bacterial lipid and envelope metabolism.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010124","count":1},{"id":"GO:0044539","count":1},{"id":"GO:0070395","count":1},{"id":"GO:0009437","count":1},{"id":"GO:0008218","count":1}]},{"hash":"308725728328451216","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071031","count":4},{"id":"GO:0006346","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0045898","count":4},{"id":"GO:0001208","count":4}]},{"hash":"974937874275305648","title":"NF-kappaB signaling and cell survival","description":"These proteins cluster around NF-kappaB pathway activation (positive regulation of canonical NF-kappaB signaling and NF-kappaB transcription factor activity) and related anti-apoptotic and inflammatory processes, with supporting terms like LPS-mediated signaling and autophagy regulation. The mix suggests a theme of NF-kappaB\u2013driven survival and inflammatory signaling, even though other terms are more peripheral.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031663","count":1},{"id":"GO:0010508","count":1},{"id":"GO:0051092","count":1},{"id":"GO:0070830","count":1},{"id":"GO:0051897","count":1}]},{"hash":"2287230647429407012","title":"Developmental signaling and cytoskeleton remodeling","description":"The top GO terms cover developmental processes across tissues (forebrain, ventricular muscle, B cell differentiation) and signaling pathways triggered by growth factors (HGF, VEGF, collagen receptor signaling), together with actin cytoskeleton organization and cell migration. This suggests a cohesive theme of growth factor\u2013driven signaling coordinating cytoskeletal remodeling during development and cellular movement.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":4},{"id":"GO:0035729","count":4},{"id":"GO:0002333","count":4},{"id":"GO:0006939","count":4},{"id":"GO:0030866","count":4}]},{"hash":"1309762529785801330","title":"Meiotic DSB Repair and Synaptonemal Complex Assembly","description":"The cluster is dominated by GO terms tying together meiotic double-strand break repair, recombination, and synaptonemal complex assembly (e.g., repair involved in meiotic recombination, SDSA, female meiosis sister chromatid cohesion). These are core features of meiosis-specific chromosome pairing and recombination, with additional links to DNA damage responses and cell-cycle checkpoints that accompany meiosis. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1990918","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0072711","count":3},{"id":"GO:0045003","count":3},{"id":"GO:0072757","count":3}]},{"hash":"489491127414637091","title":"DNA repair and genome maintenance","description":"The cluster\u2019s terms are dominated by DNA repair pathways (nucleotide excision repair, gap filling, error-prone and error-free translesion synthesis), UV-C response, and DNA replication, all pointing to maintaining genome integrity. While a couple of terms touch RNA modification (pseudouridine synthesis), the strongest signal is DNA damage response and replication maintenance.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000455","count":1},{"id":"GO:0031119","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0071897","count":1},{"id":"GO:0002206","count":1}]},{"hash":"2219603299623610705","title":"Ubiquitin-Mediated NF-kB Signaling","description":"The strongest shared signal among the terms is protein K48-linked ubiquitination and positive regulation of canonical NF-kappaB signaling, which together point to ubiquitin-dependent control of NF-kB activation in immune signaling (C-type lectin receptor pathways also relate to innate immunity). Other terms in the list appear more peripheral (BMP signaling, meiosis, leucine starvation), but the central theme is ubiquitin-mediated modulation of NF-kB in immune contexts.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1990253","count":3},{"id":"GO:0043951","count":3},{"id":"GO:0030509","count":3},{"id":"GO:0051026","count":3},{"id":"GO:0042276","count":3}]},{"hash":"1412830194305027260","title":"Gastrulation and mesoderm development signaling","description":"This cluster\u2019s top GO terms cluster around gastrulation, mesoderm development, and key signaling pathways (BMP signaling, FGFR signaling), with proteoglycan biosynthesis linking ECM components to signaling during morphogenesis. A few unrelated/obsolete terms are present, but the core theme is developmental signaling in early embryogenesis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007369","count":1},{"id":"GO:0015012","count":1},{"id":"GO:0007498","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0021772","count":1}]},{"hash":"1329605165590666534","title":"Membrane Transport","description":"This cluster shows a strong enrichment for various transport GO terms (molybdate, cysteine, methionine, lipoprotein, xenobiotic, ceramide), indicating a membrane transport module. Some unrelated terms like antigen processing for MHC I and nucleotide excision repair appear but likely reflect broad annotations of multi-function proteins. Overall, the data point to a transport-focused cluster with moderate confidence.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015689","count":4},{"id":"GO:0042883","count":4},{"id":"GO:0019885","count":4},{"id":"GO:0017004","count":4},{"id":"GO:0015821","count":4}]},{"hash":"1709125713096132500","title":"Unknown","description":"The top GO terms are highly diverse, spanning prostaglandin biosynthesis, cytokine production, fatty acid import, complement activation, startle response, glucose transport, TNF response, acrosome assembly, lipoprotein oxidation regulation, and bladder development. There isn't a single coherent function that clearly binds these four proteins; thus a confident, specific label cannot be assigned. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":2},{"id":"GO:0001816","count":2},{"id":"GO:0044539","count":2},{"id":"GO:0006957","count":2},{"id":"GO:0001964","count":2}]},{"hash":"346203277987844367","title":"Glycolysis and energy metabolism","description":"The proteins are enriched for glycolysis-related processes (canonical glycolysis, pyruvate biosynthesis, ATP biosynthesis) and responses to energy-relevant signals (glucose, insulin, epinephrine, cAMP, ATP), suggesting a cluster centered on cellular energy production and energy-sensing signaling. A few terms like programmed cell death appear but are not dominant, reinforcing the core theme of metabolic energy regulation.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042866","count":3},{"id":"GO:0010226","count":2},{"id":"GO:0009749","count":2},{"id":"GO:0012501","count":2},{"id":"GO:0006754","count":2}]},{"hash":"1988413369936835419","title":"Neural synaptic plasticity and calcium signaling","description":"The top GO terms cluster around synaptic activity and memory-related processes (long-term synaptic potentiation, excitatory postsynaptic potential, short-term memory) and calcium dynamics (positive regulation of release of sequestered calcium into cytosol), with supporting hints of neuronal development (axonogenesis) and some muscle-related processes (sarcomere organization, heart development). This suggests the proteins function together mainly in neural signaling and activity-dependent plasticity, modulated by calcium signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0071872","count":2},{"id":"GO:0007614","count":2},{"id":"GO:0051281","count":2}]},{"hash":"893534563671163836","title":"Cell cycle and endosomal trafficking","description":"The top GO terms show strong signals for cell division and nuclear dynamics (cell cycle, nuclear membrane reassembly, mitotic chromosome alignment, nucleus organization), complemented by vesicle trafficking processes (multivesicular body sorting, intralumenal vesicle formation, protein transport to vacuole, Golgi retention). This suggests the cluster\u2019s proteins link mitotic/nuclear functions with endosomal sorting and vesicle trafficking, possibly coordinating chromosome handling with protein turnover.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0031468","count":1},{"id":"GO:0007080","count":1},{"id":"GO:0043328","count":1},{"id":"GO:0045053","count":1}]},{"hash":"62979222947246512","title":"Mitochondrial respiration and mitophagy","description":"The GO terms cluster around mitochondria: mitochondrial autophagy (mitophagy), assembly of respiratory chain complexes (complex IV and respirasome), and regulation of cytochrome c release; these point to a coherent theme of mitochondrial maintenance and respiration. A few terms such as lung development or alkaloid biosynthesis appear incidental, but do not dominate the set. Therefore the label reflects the primary function of the proteins: mitochondrial respiration and turnover.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035335","count":1},{"id":"GO:0052046","count":1},{"id":"GO:0046685","count":1},{"id":"GO:0000422","count":1},{"id":"GO:0033617","count":1}]},{"hash":"1494727737841981018","title":"Embryonic neural development and brain patterning","description":"The top GO terms cluster around embryogenesis with a strong neural development signal: forebrain development, cerebral cortex regionalization, neuron migration, and brain-region differentiation, with additional terms like primitive streak formation. While there are a few broader embryonic processes included, the dominant theme is neural development and brain patterning, making this label representative. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0001764","count":2},{"id":"GO:0061452","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1895906182482788951","title":"Lipid metabolism and signaling","description":"The proteins show GO terms clustered around lipid metabolism, including triglyceride catabolism, fatty acid metabolism, and phospholipid dephosphorylation, with endocannabinoid signaling regulation suggesting lipid-mediated signaling roles. Some terms are unrelated or obsolete, so the link isn\u2019t perfect, but the dominant theme is lipid-centric metabolism and signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":3},{"id":"GO:0046839","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0097755","count":3},{"id":"GO:2000124","count":3}]},{"hash":"2115215145897534171","title":"Membrane Metabolite Transport and Mitochondrial Dynamics","description":"These proteins are enriched for transmembrane transport of small metabolites (glycine, NAD, thiamine pyrophosphate, citrate, thiosulfate) across plasma and mitochondrial membranes. The inclusion of mitochondrial membrane fission and insulin-related signaling terms suggests a role in coordinating metabolic flux with mitochondrial dynamics and insulin response.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0036233","count":2},{"id":"GO:0090149","count":2},{"id":"GO:0035352","count":2},{"id":"GO:0030974","count":2},{"id":"GO:1990845","count":2}]},{"hash":"1620639381040572764","title":"Unknown","description":"The four proteins are linked to a scattered mix of metabolic processes (biosynthesis and catabolism of lipids, vitamins, pigments, and related molecules) plus general terms like response to toxic substances and nitrogen utilization. There is no clear, single biological function that unites these GO terms, so a cohesive, specific label isn\u2019t justifiable.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":1},{"id":"GO:0009636","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0019740","count":1}]},{"hash":"2115150855871219354","title":"Neural adhesion and synapse formation","description":"The cluster centers on cell adhesion signaling (integrin pathways, cell-matrix and heterotypic adhesion) and synaptic functions (neurotransmitter secretion, synapse assembly), with associated glial regulation and developmental terms. This points to a cohesive theme of adhesion-mediated signaling and neural synapse development, even though some terms reflect broader developmental processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":3},{"id":"GO:0045123","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0034113","count":3}]},{"hash":"810082021793352038","title":"Actin-driven cell motility and polarity","description":"This cluster centers on actin cytoskeleton dynamics (ruffle assembly, actin cortical patch assembly, barbed-end capping) and processes related to cell movement and polarity (positive regulation of motility and establishment of cell polarity). Neuronal spine maintenance and various signaling responses (IL-1, hydrogen peroxide) appear as broader contexts that often accompany cytoskeletal remodeling. Overall, the proteins likely participate in actin-mediated remodeling that promotes cell migration and shape organization.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902951","count":1},{"id":"GO:0097178","count":1},{"id":"GO:0000147","count":1},{"id":"GO:2000814","count":1},{"id":"GO:0071347","count":1}]},{"hash":"2007252996044943930","title":"Embryonic development and neural differentiation","description":"This cluster centers on developmental signaling and differentiation across embryonic tissues: muscle (myoblast differentiation), neural lineage (dendrite and astrocyte differentiation, axon fasciculation), and skeletal morphogenesis (notochord, cranial skeleton). The PI3K/AKT signaling term ties these processes as a common developmental pathway, suggesting a coordinated program of embryogenesis and neural-skeletal differentiation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043491","count":3},{"id":"GO:0045663","count":3},{"id":"GO:0048701","count":2},{"id":"GO:0050773","count":2},{"id":"GO:1904237","count":2}]},{"hash":"24200129268515977","title":"Hematopoiesis and Bone Development Signaling","description":"The top GO terms point to blood cell formation and granulocyte differentiation (hemopoiesis, granulocyte differentiation), IL-2 production, and bone-related signaling (BMP pathway, osteoblast differentiation, regulation of FGF receptor signaling), suggesting a cluster centered on hematopoietic and skeletal lineage development and their signaling networks. There is some breadth (e.g., mammary gland development, iron-regulated translation), but the core theme ties to hematopoietic and bone differentiation pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901522","count":2},{"id":"GO:0060749","count":2},{"id":"GO:0045994","count":2},{"id":"GO:0045669","count":1},{"id":"GO:0030854","count":1}]},{"hash":"375642403022423269","title":"NF-kappaB signaling and immune activation","description":"The GO terms cluster around activation/regulation of the NF-kappaB pathway (canonical NF-kappaB signaling), TNF-mediated signaling, and adaptive immune response, with additional notes on RIG-I pathway regulation and apoptotic process\u2014together pointing to NF-kappaB\u2013driven immune signaling as the core function. A skin development term appears non-central to the main theme. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0043588","count":2},{"id":"GO:0007250","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0043123","count":2}]},{"hash":"520424518064325705","title":"Ubiquitin-dependent NF-\u03baB and TNF signaling","description":"Proteins are enriched for ubiquitin-dependent proteolysis and K6-linked ubiquitination, with links to NF-\u03baB activation and TNF-mediated signaling, plus regulation of apoptosis. This points to a cohesive theme of ubiquitin-controlled inflammatory signaling and cell fate decisions.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0085020","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0051092","count":2},{"id":"GO:1901253","count":2}]},{"hash":"1575920301158820688","title":"RNA and protein methylation","description":"The cluster shows enrichment for RNA guanine-N7-methylation and multiple protein methylation processes (N-terminal peptidyl-alanine trimethylation, peptidyl-lysine monomethylation), suggesting a shared function in methyltransferase activities on RNA and proteins, often tied to translation-related contexts. The presence of the translation GO term supports this link, though some other biosynthetic terms may be incidental. Overall, a cohesive theme around methylation biology.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:1901052","count":1},{"id":"GO:0018012","count":1},{"id":"GO:0042372","count":1},{"id":"GO:0036265","count":1}]},{"hash":"960679456738621731","title":"Ubiquitin-Proteasome Pathway Components","description":"The top GO terms point to ubiquitin-dependent protein degradation (including ERAD), with emphasis on K48- and K6-linked ubiquitination and related signaling such as NF-\u03baB\u2013inducing kinase activity. This indicates the cluster groups proteins involved in ubiquitin-mediated proteolysis and processing, rather than a single, narrow enzymatic function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0085020","count":3},{"id":"GO:0007250","count":3},{"id":"GO:1901253","count":3}]},{"hash":"1276141164462553200","title":"Actinobacterial sporulation and cell-wall metabolism","description":"The cluster\u2019s top GO terms cluster around sporulation (GO:0030435) and various metabolic/acetylation processes (spermidine/spermine acetylation, N-terminal propionylation, N-acetylglucosamine and glucosamine metabolism) as well as mycothiol biosynthesis, which is characteristic of Actinobacteria and linked to cell-wall biosynthesis and redox defense. Although rDNA heterochromatin formation is an outlier, the overall pattern points to sporulation-associated metabolism and cell-wall-related modifications in actinobacterial species (e.g., Streptomyces). Confidence: Medium.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":2},{"id":"GO:0030435","count":1},{"id":"GO:0032918","count":1},{"id":"GO:0061606","count":1},{"id":"GO:0032919","count":1}]},{"hash":"511424719455180840","title":"Embryonic development and lineage differentiation","description":"The top terms cluster around development and lineage specification (mesoderm development, ectodermal fate, blastocyst development, heart valve formation), with some immune lineage and gene-regulation terms (NK T cell proliferation, lymphoid progenitor differentiation, miRNA transcription) appearing as well. Despite the diversity, the strongest shared theme is developmental processes guiding differentiation across multiple lineages. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001866","count":4},{"id":"GO:0002320","count":4},{"id":"GO:0061614","count":4},{"id":"GO:0007429","count":4},{"id":"GO:0003199","count":4}]},{"hash":"1348227634725603702","title":"Epigenetic Transcription Regulation","description":"The top GO terms cluster around negative regulation of transcription by RNA polymerases I and II and chromatin-related processes (histone acetylation, heterochromatin formation), indicating a shared function in epigenetic control of gene expression. Some development-related terms appear, but they likely reflect broader regulatory roles rather than a single developmental pathway.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0090009","count":2},{"id":"GO:0048935","count":2},{"id":"GO:0072520","count":1},{"id":"GO:0043966","count":1}]},{"hash":"311611643710136774","title":"Neurodevelopment and brain regionalization","description":"The GO terms are dominated by neural development and brain patterning: neuron migration, forebrain development, cerebral cortex regionalization, and motor neuron differentiation. Some terms touch on broader embryonic patterning, but the prevailing signal is neurodevelopmental processes.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001764","count":4},{"id":"GO:0061452","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0060971","count":4},{"id":"GO:0003309","count":4}]},{"hash":"989058032718874918","title":"Cardiac development and conduction system","description":"The top GO terms are clearly centered on heart formation and electrical activity: outflow tract morphogenesis, heart development, regulation of heart rate by cardiac conduction, and specific cardiac action potential phases (AV node, His bundle, atrial) with calcium channel transport. Some terms about pain or ossification appear less directly related but can reflect broader embryonic development contexts; overall the cluster aligns best with cardiac development and the cardiac conduction system.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0003151","count":3},{"id":"GO:0086091","count":3}]},{"hash":"48408372099919739","title":"Pancreas and liver development with insulin secretion","description":"The top GO terms are dominated by endoderm-derived organ development, especially pancreas and liver, and associated hormone secretion (insulin and peptide hormones). While there are terms about barrier formation and tight junctions, the strongest signals point to organogenesis of endodermal tissues and related endocrine function, particularly pancreatic insulin secretion and liver development.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007492","count":1},{"id":"GO:0090277","count":1},{"id":"GO:0060872","count":1},{"id":"GO:0060856","count":1},{"id":"GO:0048873","count":1}]},{"hash":"2014949570709466013","title":"Steroid and lipid hormone biosynthesis","description":"The GO terms are dominated by lipid/hormone\u2013related processes\u2014prostaglandin, brassinosteroid, bile acid, testosterone, and aldosterone biosynthesis, plus vitamin D response and hormone-driven parturition\u2014pointing to a shared theme of lipid hormone production and signaling. Some outliers (alkaloid/camphor catabolism) exist, but the central pattern supports a steroid and lipid hormone biosynthesis cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":4},{"id":"GO:0033280","count":4},{"id":"GO:1900087","count":4},{"id":"GO:0010268","count":4},{"id":"GO:0060137","count":4}]},{"hash":"2266020202178459451","title":"Polyamine acetylation and amino sugar metabolism","description":"The top GO terms cluster around acetylation events (spermidine/spermine, N-terminal) and sugar-related metabolism (glucosamine, N-acetylglucosamine) plus mycothiol biosynthesis, suggesting a theme of acetylation chemistry intertwined with amino sugar pathways common in prokaryotes; a few entries (angiogenesis, leucine import regulation) appear as outliers or annotation noise.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032918","count":3},{"id":"GO:0061606","count":3},{"id":"GO:0032919","count":3},{"id":"GO:0006041","count":3},{"id":"GO:0010125","count":3}]},{"hash":"1656391207134756578","title":"Developmental Morphogenesis and Cell Adhesion","description":"The terms point to tissue development and maturation (urogenital tract, vasculature, Purkinje cells) alongside cell\u2013cell adhesion processes (calcium-dependent adhesion, intermicrovillar adhesion) and neural signaling (synaptic transmission, GABAergic). This combination suggests a theme around morphogenesis and adhesion with neural signaling involvement, rather than a single narrow function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035799","count":2},{"id":"GO:0060489","count":2},{"id":"GO:0016339","count":2},{"id":"GO:0001955","count":2},{"id":"GO:0007268","count":2}]},{"hash":"230474545118467156","title":"Innate lipoprotein sensing via TLRs and NLRP3","description":"The top GO terms point to detection of bacterial lipopeptides (diacyl and general), TLR signaling pathways (TLR4, TLR8), and NLRP3 inflammasome regulation, suggesting a shared role in innate immune sensing and inflammatory signaling. A couple of development-related terms appear unrelated, but the immune signaling terms dominate, supporting this functional theme.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070340","count":2},{"id":"GO:0007413","count":2},{"id":"GO:1900227","count":2},{"id":"GO:0070100","count":2},{"id":"GO:0034158","count":2}]},{"hash":"1223307330191375109","title":"Diverse Membrane Transporters","description":"The Top Terms are dominated by transmembrane transport functions for a variety of solutes (phosphate and sodium ions, nitrite, dehydroascorbic acid, xenobiotics), which points to a cluster of membrane transporter proteins with broad substrate specificity. Some terms like lactose biosynthesis are metabolic, but the strongest signal is transporter activity, suggesting a label for diverse solute transporters.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904728","count":3},{"id":"GO:0070837","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0006004","count":3},{"id":"GO:0015707","count":3}]},{"hash":"415238463991727374","title":"Embryonic organogenesis and muscle development","description":"The top terms cluster around developmental processes such as myoblast fusion, heart development, ossification, angiogenesis, and multicellular organism development, suggesting the proteins are involved in embryonic tissue morphogenesis and organ formation. A couple of terms (potassium channel clustering, Fc-epsilon receptor signaling) are less directly related and may reflect multifunctional proteins or broader annotations, but the dominant theme is developmental morphogenesis. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007520","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0001525","count":3}]},{"hash":"1550043184623402003","title":"ER Stress and Protein Quality Control","description":"These proteins cluster around endoplasmic reticulum (ER)\u2013associated quality control, including responses to toxic substances, unfolded protein handling, ER-associated degradation (ERAD), protein deglycosylation, and deubiquitination. While there are some regulatory terms related to transcription and DNA binding, the dominant signals point to ER stress management and protein quality control mechanisms.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097237","count":3},{"id":"GO:0006517","count":3},{"id":"GO:0033132","count":3},{"id":"GO:0006357","count":3},{"id":"GO:1902236","count":3}]},{"hash":"1750772999214563665","title":"Ubiquitin-regulated stress and immune signaling","description":"The top GO terms cluster around ubiquitin-related regulation (deubiquitination; ubiquitin ligase activity) and immune signaling pathways (TNF-mediated signaling; C-type lectin receptor signaling). There are also stress and transcriptional regulation themes (response to zinc and salt stress; hypoxia-associated transcription). Taken together, the proteins appear to participate in a module where ubiquitin-mediated regulation interfaces with immune/stress signaling, despite some terms being obsolete or variably connected. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061418","count":2},{"id":"GO:0002223","count":2},{"id":"GO:0016579","count":2},{"id":"GO:0010043","count":2},{"id":"GO:0006521","count":2}]},{"hash":"330004513944428930","title":"Immune cell activation and differentiation regulation","description":"The GO terms cluster around how immune cells activate and differentiate (dendritic cells, NK cells, B cells, macrophages), including cytokine signaling (IL-4 production, STAT phosphorylation) and regulation of immune responses. While there are a couple of terms related to neural or cardiovascular processes, the dominant theme is immune signaling and immune cell state regulation, suggesting these proteins function in modulating immune cell activity and development.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0086091","count":1},{"id":"GO:0019226","count":1},{"id":"GO:0038033","count":1},{"id":"GO:0060665","count":1},{"id":"GO:0002860","count":1}]},{"hash":"862332765991665900","title":"RNA Splicing and Processing Machinery","description":"The cluster\u2019s top GO terms are dominated by RNA metabolism topics\u2014tRNA processing, rRNA maturation, spliceosome assembly and RNA splicing\u2014indicating a cohesive function in RNA processing and spliceosome machinery. A couple of terms (hair cycle, pericentric heterochromatin formation) are less directly connected but do not outweigh the central RNA-processing theme.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":2},{"id":"GO:1990141","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0000387","count":2},{"id":"GO:0030490","count":2}]},{"hash":"1269044216633929237","title":"Embryonic organ morphogenesis (heart, muscle, kidney)","description":"The top GO terms point to morphogenesis and organ development across several tissues\u2014heart (sinus venosus morphogenesis, right ventricle formation), skeletal muscle differentiation, diaphragm development, and nephron tubule morphogenesis\u2014suggesting a broad theme of embryonic organogenesis and tissue differentiation. Some terms like circadian regulation or glucose-responsive transcription are peripheral, but the common thread remains developmental morphogenesis. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003236","count":3},{"id":"GO:0003219","count":3},{"id":"GO:0070368","count":3},{"id":"GO:0032922","count":3},{"id":"GO:0072050","count":3}]},{"hash":"1737207777528044886","title":"Selective organellar autophagy","description":"GO terms indicate autophagy targeting specific organelles (Cvt pathway, mitophagy, nucleus piecemeal autophagy), suggesting the cluster comprises proteins involved in organelle-selective autophagy rather than general transcription or signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032258","count":2},{"id":"GO:0000422","count":2},{"id":"GO:0044805","count":2},{"id":"GO:0034727","count":2},{"id":"GO:0006501","count":2}]},{"hash":"58514436479870868","title":"Developmental signaling and morphogenesis regulators","description":"This cluster shows a mix of GO terms focused on signaling and developmental regulation, including regulation of calcineurin-NFAT signaling, morphogenesis, cell migration, ciliogenesis, and insulin/IGF signaling, suggesting broad developmental signaling roles rather than a single cohesive process.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":2},{"id":"GO:0007480","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0021816","count":1},{"id":"GO:1900087","count":1}]},{"hash":"1613391806677596836","title":"ER Stress and Protein Quality Control","description":"The top GO terms cluster around endoplasmic reticulum protein handling, including deglycosylation, ER-associated degradation, unfolded protein response, deubiquitination, and regulation of ER-stress\u2013related apoptosis, all pointing to ER quality control and stress response; additional terms like transcription regulation, DNA repair, and NK cell modulation appear as broader associations, but the dominant signal is ER folding/homeostasis. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097237","count":3},{"id":"GO:0006517","count":3},{"id":"GO:0033132","count":3},{"id":"GO:0006357","count":3},{"id":"GO:1902236","count":3}]},{"hash":"1629097098840420253","title":"Inflammation and programmed cell death signaling","description":"These proteins appear tied to inflammatory signaling and programmed cell death, including necroptosis, apoptosis execution, and NF-kappaB pathway regulation, with connections to wound healing and immune response.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060545","count":1},{"id":"GO:0042060","count":1},{"id":"GO:0043123","count":1},{"id":"GO:0097527","count":1},{"id":"GO:0048538","count":1}]},{"hash":"566752049925671412","title":"Innate Immune Activation and Phagocytosis","description":"This cluster is enriched for GO terms related to innate immune signaling, including activation of non-canonical NF-kappaB pathways, innate immune response-activating signaling, and dendritic cell chemotaxis, as well as processes promoting phagocytosis. The presence of phagocytosis and dendritic cell\u2013associated terms suggests a theme around immune cell activation and function, with supportive links to protein folding and ER stress that can accompany immune responses. While a few terms touch on cell cycle regulation and senescence, the dominant signal points to innate immune activation and phagocytic/dendritic cell activity.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"protein folding","top_go_terms":[{"id":"GO:1901224","count":3},{"id":"GO:0071157","count":3},{"id":"GO:0050766","count":3},{"id":"GO:1900026","count":3},{"id":"GO:2000510","count":3}]},{"hash":"1967339395015792143","title":"Angiogenesis and ECM remodeling during development","description":"These proteins show strong signals for angiogenesis (sprouting angiogenesis, endothelial migration) and extracellular matrix organization (collagen fibril organization), both key to vascular development and tissue remodeling. Additional terms related to development (spinal cord development) and ancillary processes like lipid transport and immune signaling suggest a broader theme of developmental vascular-ECM remodeling with supporting metabolic and immune roles. Confidence: Medium","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035813","count":2},{"id":"GO:0043542","count":2},{"id":"GO:0002040","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0016540","count":2}]},{"hash":"2002029913910684217","title":"Neural signaling and synaptic function","description":"The top GO terms cluster around neuronal activity: responses to acetylcholine, regulation of norepinephrine secretion, inhibitory postsynaptic potential, calcium ion import, optic nerve morphogenesis, and nervous-system\u2013level regulation of respiration. Despite a few outliers (e.g., acrosome reaction, CoA-transferase regulation), the majority point to neural signaling and calcium-dependent synaptic processes. Confidence: High","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905920","count":3},{"id":"GO:0002087","count":3},{"id":"GO:0007340","count":3},{"id":"GO:1905144","count":3},{"id":"GO:0071294","count":3}]},{"hash":"2242646904620231618","title":"Neural development and signaling","description":"These proteins are enriched for GO terms tied to neural differentiation and signaling, including transmission of nerve impulse, dendrite development, astrocyte differentiation, and BMP/PI3K-Akt signaling. Additional terms on cell adhesion and migration align with neural tissue morphogenesis. A few broader developmental terms are present, but the dominant theme is neural development and neuronal signaling.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":2},{"id":"GO:1902955","count":2},{"id":"GO:0001954","count":2},{"id":"GO:0043491","count":2},{"id":"GO:0050773","count":2}]},{"hash":"393126120929079339","title":"Cardiac conduction and action potentials","description":"The cluster shows strong enrichment for heart-related terms (outflow tract morphogenesis, regulation of heart rate by cardiac conduction, AV node and His bundle action potentials, atrial muscle action potential regulation, HV calcium channel\u2013mediated calcium transport), pointing to proteins involved in cardiac electrical activity and impulse propagation, despite a couple unrelated terms in the mix. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":1},{"id":"GO:0086091","count":1},{"id":"GO:0086045","count":1},{"id":"GO:0050966","count":1},{"id":"GO:0061577","count":1}]},{"hash":"53872390833130370","title":"Arthropod cuticle development and innate immune signaling","description":"Rationale: Most terms describe arthropod chitin-containing cuticle development and molting (ecdysis), with additional signaling related to innate immunity (NF-kappaB activation, IL-1/IL-6/IL-8 responses) and apoptosis. A single seemingly unrelated term (lung development) may be incidental. Overall, the cluster centers on arthropod cuticle biology plus immune signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":3},{"id":"GO:0007250","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0072606","count":2}]},{"hash":"578245280216758333","title":"Unknown","description":"The GO terms are extremely diverse, spanning mitotic DNA damage checkpoints, cell adhesion, fungal ascospore formation, lung and neural development, fiber-type transitions, locomotion, adenosine synthesis, inflammation regulation, and epithelial differentiation. There isn\u2019t a single coherent functional theme tying these proteins together, suggesting the cluster does not represent a specific, easily interpretable biological function. ","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031573","count":3},{"id":"GO:0098609","count":3},{"id":"GO:0030437","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0022011","count":3}]},{"hash":"2292403835789374024","title":"Unknown","description":"The GO terms are highly heterogeneous, ranging from DNA-templated transcription and cell cycle regulation to various developmental processes (forebrain development, sprouting angiogenesis, chorionic trophoblast differentiation, blood circulation) and even plant-specific metabolism and mRNA stabilization. With no evident shared pathway and no edges linking the proteins, there isn't a coherent functional theme to define a specific label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0070345","count":1},{"id":"GO:0030900","count":1},{"id":"GO:0051726","count":1},{"id":"GO:0002040","count":1}]},{"hash":"90236871165231948","title":"Vertebrate organ development","description":"This cluster is dominated by developmental terms spanning multiple organs (forebrain, face, ureter, cardiac muscle, Harderian gland), suggesting a general theme of embryonic organogenesis across tissues, with other terms being less central or ancillary.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035799","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0070384","count":3},{"id":"GO:0048738","count":3},{"id":"GO:0015976","count":3}]},{"hash":"900235258969800075","title":"Nuclear transport and mitotic chromosome dynamics","description":"This cluster centers on nuclear transport (nuclear import/export and protein shuttling) and mitotic chromosome processes (alignment and nuclear envelope remodeling). The top terms repeatedly reference nuclear import/export, regulation of protein import, and mitotic chromosome events, suggesting a cohesive theme around nuclear transport and mitosis.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006409","count":3},{"id":"GO:0006607","count":2},{"id":"GO:0042306","count":2},{"id":"GO:0007077","count":2},{"id":"GO:0075733","count":2}]},{"hash":"1054950924821323809","title":"Vertebrate embryogenesis and mesoderm formation","description":"The dominant GO terms point to embryogenesis\u2014blastocyst formation, mesoderm differentiation, notochord morphogenesis, and brain region development\u2014while other terms appear as noise or inconsistent annotations (e.g., plant brassinosteroid response). This suggests a core theme of vertebrate embryogenesis and germ layer formation, but the presence of unrelated terms lowers confidence.","confidence":"Low","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:2001034","count":1},{"id":"GO:0009741","count":1},{"id":"GO:0060275","count":1},{"id":"GO:0035574","count":1}]},{"hash":"619065097069985660","title":"RNA Pol II transcription initiation and chromatin remodeling","description":"The top terms cluster around transcription initiation at RNA polymerase II promoters and chromatin remodeling coupled to initiation (GO:0006367, GO:0045815), with a nearby signal of cell-cycle transcription regulation (GO:0010971). The lack of edges suggests annotation-based grouping rather than a defined complex, but the shared focus on transcription initiation and chromatin dynamics justifies this label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031496","count":1},{"id":"GO:0061412","count":1},{"id":"GO:0043969","count":1},{"id":"GO:0045815","count":1},{"id":"GO:0010971","count":1}]},{"hash":"759076436336053926","title":"Ribosome Biogenesis and Translation Initiation","description":"The Top Terms show cytosolic ribosome assembly, formation of translation preinitiation complexes, translational initiation, translation, and export-related steps for ribosomal subunits, all pointing to roles in ribosome assembly and the initiation phase of protein synthesis. A few terms related to splicing or DNA-binding regulation appear minor in comparison. Overall, the cluster is best described by ribosome biogenesis and translation initiation functions.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042256","count":1},{"id":"GO:0002176","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0045947","count":1},{"id":"GO:0006413","count":1}]},{"hash":"2232320020869655237","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0048254","count":2},{"id":"GO:0006356","count":2},{"id":"GO:1990258","count":2},{"id":"GO:0031167","count":2}]},{"hash":"1444095525680508337","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034344","count":1},{"id":"GO:0002230","count":1},{"id":"GO:0071031","count":1},{"id":"GO:0000462","count":1},{"id":"GO:1903608","count":1}]},{"hash":"2259782230956314777","title":"Developmental signaling and transcription control","description":"This cluster is characterized by embryonic development terms (gastrulation, forebrain development, spinal cord development) alongside various signaling pathways (GPCR signaling, growth hormone response, glucose-mediated signaling) and transcription regulation, suggesting proteins that function in development through signaling and transcriptional control.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0007369","count":1},{"id":"GO:0030900","count":1},{"id":"GO:0007200","count":1},{"id":"GO:0030042","count":1}]},{"hash":"1785546353202665190","title":"DNA replication and transcription processes","description":"The top GO terms are dominated by DNA replication and related activities (DNA replication, primer synthesis, unwinding), along with DNA-templated transcription and recombination, with a note of viral genome replication. Some terms concern maturation of rRNA\u2014an RNA-processing hint rather than core replication\u2014plus a single ubiquitin-specific protease activity term as an outlier. Together, the core theme is DNA replication and transcription machinery, with minor RNA processing associations.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006268","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006269","count":2},{"id":"GO:0019079","count":2}]},{"hash":"263671028041987425","title":"Drosophila egg chamber development and protein trafficking","description":"Top GO terms indicate a focus on ovarian/follicle cell lineage development and epithelial morphogenesis in Drosophila, combined with intracellular trafficking processes such as ubiquitin-dependent endocytosis and multivesicular body\u2013mediated protein sorting. The mix of egg chamber formation, germarium-related development, and polarity maintenance, alongside trafficking pathways, supports a cohesive module centered on Drosophila ovarian development and protein trafficking.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070086","count":1},{"id":"GO:0045450","count":1},{"id":"GO:1904669","count":1},{"id":"GO:0043328","count":1},{"id":"GO:0043162","count":1}]},{"hash":"130843517124619646","title":"mRNA splicing and translation initiation regulation","description":"The proteins cluster around RNA metabolism, with terms for splicing regulation via the spliceosome (positive/negative regulation), splice site recognition, mRNA modification and stabilization, and initiation of translation (eIF4F complex assembly; regulation of translational initiation). This suggests a functional theme of RNA processing and translation control.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1905663","count":3},{"id":"GO:0097010","count":3},{"id":"GO:0016556","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0048255","count":3}]},{"hash":"1157946688579391581","title":"Growth-factor signaling and cytoskeleton remodeling in development","description":"The top GO terms cluster around growth factor receptor signaling (HGF, VEGF, collagen-activated RTKs), regulation of JUN kinase activity, and actin cytoskeleton organization, along with processes like fibroblast migration and development of heart and vascular tissues, suggesting a shared theme of signaling-driven cytoskeletal remodeling during development across multiple tissues.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0035729","count":3},{"id":"GO:0002333","count":3},{"id":"GO:0006939","count":3},{"id":"GO:0030866","count":3}]},{"hash":"374017333204510463","title":"Membrane Transport and Ion Homeostasis","description":"This cluster centers on membrane transport of ions and small molecules (oxalate, bicarbonate, sulfate, and L-aspartate) and processes tied to membrane potential and intracellular pH. Additional terms like gastric acid secretion, sperm capacitation, and sporulation reflect ion- and pH-dependent biological activities. Together, these terms suggest proteins primarily involved in transport across membranes and maintenance of ionic balance, rather than a single metabolic pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019532","count":1},{"id":"GO:0048240","count":1},{"id":"GO:0030435","count":1},{"id":"GO:0051454","count":1},{"id":"GO:0006355","count":1}]},{"hash":"2117068632898290852","title":"Nucleotide Metabolism and DNA Replication Initiation","description":"These proteins share multiple GO terms tied to nucleotide metabolism (purine interconversion, various nucleotide phosphorylation/ salvage pathways, CDP/GTP metabolism) and DNA replication initiation, suggesting a common role in providing nucleotides for DNA synthesis. The brain and liver development annotations are broad tissue terms and likely not central to the core function of the cluster.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015951","count":3},{"id":"GO:0046041","count":3},{"id":"GO:0046705","count":3},{"id":"GO:0006270","count":3},{"id":"GO:0046939","count":3}]},{"hash":"1093147308774512193","title":"Neuronal differentiation and brain development","description":"These GO terms converge on neural development and neuron differentiation across CNS regions (spinal cord, cerebral cortex, subpallium, forebrain) and include neuron migration and neuron fate commitment. Although a couple terms touch broader organogenesis (endocrine pancreas, bronchiole development), the dominant signal is neural lineage specification, supporting a label centered on neuronal differentiation and brain development.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021530","count":3},{"id":"GO:0021520","count":3},{"id":"GO:0021892","count":3},{"id":"GO:0060163","count":3},{"id":"GO:0031018","count":3}]},{"hash":"1628006888608306923","title":"Wnt-mediated Development and Cell Differentiation","description":"The GO terms cluster around broad developmental processes across multiple tissues, including gland development (harderian and lacrimal), neural lineage differentiation (forebrain radial glial cells, astrocyte fate, neuroblast division), and immune cell differentiation (B cell and dendritic cell). The presence of canonical Wnt signaling terms related to EMT and apoptosis, along with chromatin remodeling, suggests a general theme of developmental signaling guiding cell fate decisions across tissues, rather than a single, highly specific function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070384","count":3},{"id":"GO:0044334","count":3},{"id":"GO:0021861","count":3},{"id":"GO:0045578","count":3},{"id":"GO:2001200","count":3}]},{"hash":"1927297901813919890","title":"Unknown","description":"The GO terms cover a wide range of cellular processes\u2014energy metabolism, transport, ubiquitin turnover, signaling, protein assembly, development and lifespan, and even viral processes\u2014without a unifying function. Because there is no clear shared pathway or function among the proteins, a single cohesive label cannot be justified.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":1},{"id":"GO:0071432","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0010992","count":1},{"id":"GO:0008286","count":1}]},{"hash":"687387716890131627","title":"Embryonic development and tissue differentiation","description":"The top GO terms point to broad developmental and differentiation processes across multiple tissues (brain/forebrain, neuron migration, heart development, gonad development, pancreatic cell differentiation). The presence of both organ-specific development terms and a general regulatory term (negative regulation of transcription by RNA polymerase II) suggests a cluster of proteins involved in coordinating embryonic development and tissue differentiation rather than a single, cohesive pathway. Confidence: Medium.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0001764","count":1}]},{"hash":"484235533068610863","title":"Cytoskeleton remodeling and cell polarity","description":"The top GO terms cluster around actin filament dynamics (actin filament branching; Cdc42 and Ras signaling), junction formation (apical junction assembly), and organelle positioning (melanosome assembly; intracellular distribution of mitochondria) \u2013 all pointing to coordinated cytoskeletal remodeling that establishes and maintains cell polarity and organelle trafficking. Some terms appear tangential, but the dominant theme is cytoskeleton-driven polarity and trafficking.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903232","count":3},{"id":"GO:0071338","count":3},{"id":"GO:0043297","count":3},{"id":"GO:0007097","count":3},{"id":"GO:0046579","count":3}]},{"hash":"1500820809357622887","title":"Vesicle trafficking and exosome biogenesis","description":"The GO terms cluster around MVB- and vacuole-directed protein transport (ubiquitin-dependent and -independent), exosomal secretion, and related membrane trafficking processes. Additional terms like cilium assembly and regulation of adherens junctions reflect vesicle delivery pathways that influence cell adhesion and migration. Taken together, this cluster points to a vesicle trafficking/secretion module, especially MVB/exosome\u2013mediated routes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043328","count":1},{"id":"GO:0060271","count":1},{"id":"GO:1990182","count":1},{"id":"GO:1903387","count":1},{"id":"GO:0031286","count":1}]},{"hash":"800670985149112643","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060743","count":2},{"id":"GO:0001824","count":2},{"id":"GO:0035050","count":1},{"id":"GO:0060841","count":1},{"id":"GO:0043305","count":1}]},{"hash":"1534763282893969663","title":"Unknown","description":"The GO terms in this cluster are very diverse (growth-factor responses, T cell homeostasis, development, and various RNA-processing processes) with no clear, single shared function linking the proteins. Because there is no cohesive theme, I label this cluster Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044344","count":1},{"id":"GO:0002635","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0097403","count":1}]},{"hash":"2272767930946200979","title":"Actin Cytoskeleton Remodeling Signaling","description":"The terms show a common theme of actin dynamics (filament branching, stress fibers, podosome assembly) coordinated by signaling pathways (Rac, ephrin, T cell receptor) and processes involving cell polarity, adhesion (tight junctions), phagocytosis, and synaptic plasticity. This points to a cluster of proteins that collectively regulate actin remodeling in response to signaling to control cell shape, movement, and junctional structures.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090135","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0051496","count":3},{"id":"GO:0050852","count":3}]},{"hash":"433500045194054562","title":"NF-kappaB signaling and adaptive immunity","description":"This cluster centers on NF-kappaB activation/regulation and TNF signaling, with links to immune response and antigen presentation (MHC I biosynthesis, adaptive immunity). Some terms are flagged obsolete, but the core theme is immune activation via NF-kappaB.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0007182","count":2},{"id":"GO:0043123","count":2},{"id":"GO:1903265","count":2}]},{"hash":"132499338060011471","title":"Lipoprotein metabolism and cholesterol transport","description":"The top GO terms cluster around lipoprotein biology: very-low-density lipoprotein particle assembly; chylomicron remnant clearance; cholesterol metabolic process; cholesterol efflux; lipoprotein metabolic process. There is a cohesive theme of lipid transport and cholesterol handling. A couple of terms (transcription by RNA polymerase I, nucleotide-excision repair) seem unrelated to the main theme, likely background noise or tool artifact.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006360","count":1},{"id":"GO:0070816","count":1},{"id":"GO:0006289","count":1},{"id":"GO:0034379","count":1},{"id":"GO:0048261","count":1}]},{"hash":"2234408297762869115","title":"Developmental transcriptional regulation","description":"This cluster shows GO terms centered on transcriptional control (negative regulation of transcription by RNA polymerase II, miRNA transcription) along with broad developmental processes (mesoderm and ectoderm development, lymphoid lineage differentiation, heart-related EMT). The common thread is regulation of gene expression during development and cell fate decisions, rather than a single pathway. Confidence: Medium","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0001866","count":2},{"id":"GO:0002320","count":2},{"id":"GO:0061614","count":2},{"id":"GO:0007429","count":2}]},{"hash":"1814923271579984484","title":"Hair Keratinization","description":"The dominant GO terms are keratinization and hair cycle, suggesting these proteins are involved in hair follicle keratin formation and cycling. The shared annotations point to keratin-related structural proteins or regulators tied to hair growth, justifying a label focused on hair keratinization.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":3},{"id":"GO:0042633","count":3}]},{"hash":"1941784788310021987","title":"Vascular and cardiac development with actin signaling","description":"This cluster shows a strong tilt toward developmental processes in the vasculature and heart (e.g., ventricular cardiac muscle cell development, VEGF signaling, collagen-RTK signaling) as well as cytoskeletal remodeling and cell migration (cortical actin organization, fibroblast migration, JUN kinase regulation). While a few terms touch other lineages (forebrain, B cell differentiation), the convergence on vascular/cardiac development and actin-mediated signaling provides a coherent theme for the proteins in this cluster.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0035729","count":3},{"id":"GO:0002333","count":3},{"id":"GO:0006939","count":3},{"id":"GO:0030866","count":3}]},{"hash":"2074816124185375694","title":"Mitotic progression and DNA replication","description":"The top GO terms converge on DNA replication, kinetochore localization, meiotic recombination repair, and cell-cycle regulation, including CDK activity and checkpoint signaling. This points to proteins involved in coordinating genome replication with chromosome segregation during cell division, hence a label reflecting mitotic progression and DNA replication control.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034501","count":2},{"id":"GO:1990918","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0043508","count":1},{"id":"GO:0005983","count":1}]},{"hash":"1522292251072592143","title":"Unknown","description":"The proteins show a wide, inconsistent mix of GO terms (development, metabolism, chemotaxis, differentiation, angiogenesis, etc.) with no shared pathway and no edges, so there is no cohesive theme to label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":1},{"id":"GO:0000162","count":1},{"id":"GO:0046104","count":1},{"id":"GO:0006935","count":1},{"id":"GO:0030154","count":1}]},{"hash":"116818408468258093","title":"Mitotic cell cycle regulation","description":"These proteins appear linked to cell-cycle progression and mitosis, with GO terms for G1/S and G2/M transitions, cell division, spindle pole separation, and chromosome condensation. While there are also proliferative signaling terms (insulin receptor, Wnt), the dominant theme is regulation of mitotic entry/exit and overall cell division.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046626","count":2},{"id":"GO:0060070","count":2},{"id":"GO:0000082","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051301","count":2}]},{"hash":"2119943168861000614","title":"Unknown","description":"The set of GO terms covers disparate processes: immune signaling, multiple developmental processes, metal ion and oxidative stress responses, and nutrient signals, with no clear, shared function across the proteins and no network connectivity. Therefore no cohesive cluster theme can be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071353","count":2},{"id":"GO:0060325","count":2},{"id":"GO:0060135","count":1},{"id":"GO:0030324","count":1},{"id":"GO:0010269","count":1}]},{"hash":"659358562297043220","title":"Chromosome segregation and spindle/cytoskeleton dynamics","description":"The terms point to processes governing chromosome segregation and spindle orientation, including sister chromatid biorientation, centromeric cohesion, spindle orientation checkpoint signaling, and septin ring organization/disassembly. Together these suggest a common theme of chromosome dynamics and cytoskeletal remodeling in cell division, with one outlier neuronal signaling term likely annotation noise. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051388","count":1},{"id":"GO:0031134","count":1},{"id":"GO:0090219","count":1},{"id":"GO:0032186","count":1},{"id":"GO:0031578","count":1}]},{"hash":"242687582861684056","title":"Neuronal development and dendrite signaling","description":"Based on GO terms, there is emphasis on transmission of nerve impulse, regulation of dendrite development, astrocyte differentiation, BMP and PI3K signaling, and cell adhesion/migration \u2014 all pointing to neural development and dendritic/neuronal maturation with glial interactions.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":3},{"id":"GO:1902955","count":3},{"id":"GO:0001954","count":3},{"id":"GO:0043491","count":3},{"id":"GO:0050773","count":3}]},{"hash":"1440724807176415712","title":"Neural signaling and development","description":"This cluster centers on GO terms like transmission of nerve impulse, dendrite development, astrocyte differentiation, and related signaling pathways (e.g., BMP signaling, PI3K/AKT), suggesting a cohesive theme of neuronal signaling and neural development rather than non-neural processes.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":3},{"id":"GO:1902955","count":3},{"id":"GO:0001954","count":3},{"id":"GO:0043491","count":3},{"id":"GO:0050773","count":3}]},{"hash":"1146804149246205413","title":"Organ development and tissue morphogenesis","description":"These GO terms cluster around developmental morphogenesis and organ formation, including keratinocyte proliferation, hair follicle and gland development, and lung development, with hints of Hedgehog signaling and mesenchymal-epithelial interactions guiding branching and cell migration. This suggests a cohesive theme of organ morphogenesis and tissue patterning.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010838","count":3},{"id":"GO:0008589","count":3},{"id":"GO:0008078","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0070384","count":3}]},{"hash":"595305751922986573","title":"Calcium-dependent cell adhesion and actin cytoskeleton regulation","description":"The top GO terms are dominated by calcium-dependent cell\u2013cell adhesion and regulation of actin cytoskeleton organization linked to cell\u2013cell adhesion, including pseudopodium assembly and localization to cortical microtubule cytoskeleton. This points to a cohesive theme of adhesion-driven cytoskeletal dynamics that underpin epithelial interactions and morphogenesis. Some terms (neuronal differentiation, heart rate regulation) are broader or less directly connected, but the core cluster clearly centers on adhesion and cytoskeletal regulation. Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086091","count":1},{"id":"GO:0031274","count":1},{"id":"GO:0060769","count":1},{"id":"GO:0016339","count":1},{"id":"GO:0090138","count":1}]},{"hash":"628102911543081160","title":"Rab GTPase\u2013mediated vesicle trafficking and membrane targeting","description":"The cluster is dominated by GO terms tied to Rab signaling and GTPase activity, plus geranylgeranylation which anchors Rab proteins to membranes and enables trafficking. Together with protein transport and membrane targeting regulation, this suggests a Rab GTPase\u2013driven vesicle trafficking program. Some terms appear organism-specific (e.g., swim bladder inflation, iridophore differentiation) and less central to the core function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050771","count":2},{"id":"GO:0032482","count":2},{"id":"GO:0048798","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0090630","count":1}]},{"hash":"1373624403386132131","title":"Axon guidance and neuronal signaling","description":"GO terms point to ephrin receptor signaling, axon extension/axogenesis regulation, ERK signaling, and cytoskeletal remodeling, all consistent with neuronal development and axon guidance; peripheral terms like T cell receptor signaling may reflect shared signaling motifs rather than a separate function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0045956","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0050852","count":2}]},{"hash":"887346241126499887","title":"Mammalian organ development and transcriptional regulation","description":"This cluster\u2019s top terms center on developmental processes across various mammalian tissues, notably glandular and reproductive organs (male gonad development, prostate gland acinus development, Harderian gland development) plus general transcriptional regulation (DNA-templated transcription) and signaling control (NF-kappaB). The common theme is developmental regulation of organ/tissue formation with transcriptional control, though the terms are diverse beyond a single pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0060528","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0008584","count":2}]},{"hash":"1117605064076465564","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035050","count":3},{"id":"GO:0060841","count":3},{"id":"GO:0043305","count":3},{"id":"GO:0001544","count":3},{"id":"GO:0061146","count":3}]},{"hash":"1682009375900570618","title":"Unknown","description":"The GO terms span diverse biological themes, including lipid metabolism (unsaturated fatty acid biosynthesis, ergosterol regulation, MIPC metabolism) and various tissue- or process-specific roles (nitric oxide biosynthesis, nitrate assimilation, mitochondrial inheritance, CNS myelin maintenance, sebaceous gland differentiation). This lack of a single coherent function suggests the proteins do not share a unified biological role in this cluster.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006809","count":3},{"id":"GO:0006636","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0000001","count":3}]},{"hash":"6886344701987699","title":"Immune Cell Differentiation and Germinal Center Formation","description":"Top terms point strongly to immune system development and differentiation, with germinal center formation, dendritic cell differentiation, and pro-T cell differentiation being prominent. Additional terms about isotype switching and ubiquitin-dependent proteolysis fit the broader context of immune cell maturation and function. While some terms touch on other developmental processes, the immune-related signals dominate, supporting a label focused on immune differentiation and germinal center biology.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":2},{"id":"GO:0002467","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0060806","count":1},{"id":"GO:2001200","count":1}]},{"hash":"1538366043134635849","title":"Unknown","description":"There are no GO terms or network connections to tie these proteins to a common function. With zero edges/triangles and no top terms, there is no apparent biological theme to guide a label. Therefore the cluster is best labeled Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"874421597766162995","title":"Ubiquitin-Dependent NF-kappaB Signaling","description":"The top GO terms include ubiquitin-related processes (K6-linked ubiquitination and ubiquitin-dependent protein catabolic process) and a term for activation of NF-kappaB-inducing kinase, which together suggest a core function in ubiquitin-mediated regulation of NF-kappaB signaling. Other terms appear more tissue- or process-specific or are obsolete, likely reflecting annotation noise, but the ubiquitination and NF-kappaB-related terms provide a cohesive theme for this cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0032508","count":1},{"id":"GO:0085020","count":1},{"id":"GO:0007250","count":1}]},{"hash":"1774165047537709577","title":"Unknown","description":"The top GO terms span developmental processes (skin, multicellular development, morphogenesis), protein quality control (ubiquitin-dependent ERAD, polyubiquitination), intracellular trafficking (ER to Golgi transport), and signaling (NF-kappaB). There is no single cohesive function connecting these terms, so a confident, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0006888","count":2}]},{"hash":"2211988450384461889","title":"Developmental transcriptional regulation and neural differentiation","description":"The GO terms point to regulation of gene expression during development, with chromatin remodeling and negative regulation of transcription by RNA polymerase II being core signals. Several terms specifically reflect neural development (forebrain radial glial cell differentiation, astrocyte fate commitment), as well as Wnt signaling roles in development, suggesting a theme of developmental transcriptional control guiding neural differentiation, despite a few non-neural morphogenesis terms present. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0003203","count":2},{"id":"GO:0070384","count":1},{"id":"GO:0045578","count":1}]},{"hash":"582238930420772148","title":"Unknown","description":"These GO terms span skeletal muscle development, immune cell differentiation, endocrine system development, organ morphogenesis, ubiquitin-dependent protein catabolic process, and even cell cycle regulation\u2014essentially a broad mix with no single, shared function. With no edges and no cohesive GO theme, there isn\u2019t a clear cluster-defining biology to label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":2},{"id":"GO:0002467","count":1},{"id":"GO:0042787","count":1},{"id":"GO:0060806","count":1},{"id":"GO:2001200","count":1}]},{"hash":"133956845463473255","title":"ER-Golgi Trafficking and Protein Processing","description":"Most terms point to the secretory pathway, with ER-to-Golgi vesicle transport, Golgi retention, and general protein processing dominating the set. While a few terms relate to oxidative stress or centrosomal regulation, the strongest signal is trafficking and processing through the ER-Golgi axis, supporting a label focused on the secretory pathway. Confidence in this label is Moderate.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":1},{"id":"GO:2000158","count":1},{"id":"GO:0034599","count":1},{"id":"GO:1903007","count":1},{"id":"GO:0006888","count":1}]},{"hash":"1520669053397490008","title":"Thermal Response and Membrane Potential","description":"This cluster is dominated by terms tied to temperature-related responses (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis) and to membrane potential/proton transport, suggesting a shared theme around cellular heat sensing and energy regulation. Some unrelated terms appear, but the core enrichment points to thermal response coupled with energetic/ionic regulation.","confidence":"Low","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0042391","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0015991","count":1}]},{"hash":"817665020764759291","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003309","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0031018","count":2},{"id":"GO:0021516","count":2},{"id":"GO:0000122","count":2}]},{"hash":"544389744369340408","title":"Developmental transcriptional regulation","description":"The cluster showing terms for transcription regulation (negative regulation of transcription by RNA polymerase II; DNA-templated transcription) alongside several embryonic and developmental processes (left-right pattern formation, placenta development, cartilage morphogenesis, EMT in endocardial cushion formation) suggests proteins that modulate transcription during development. While terms span multiple processes, the common theme is transcriptional control in a developmental context.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0046022","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0010729","count":2}]},{"hash":"305376857231537174","title":"Hemostasis and endothelial barrier regulation","description":"Based on the GO terms, the proteins cluster around blood coagulation, regulation of coagulation, and maintenance of endothelial barrier/permeability, with supporting signals involving GPCR pathways and cell-matrix interactions. The presence of seminal clot liquefaction also ties into coagulation processes, though some terms (e.g., response to yeast, biomineral development) are less directly connected, making this a coherent but not exclusively tight cluster around vascular/hemostatic regulation.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902947","count":2},{"id":"GO:0070684","count":2},{"id":"GO:0045415","count":2},{"id":"GO:0007596","count":2},{"id":"GO:1900738","count":2}]},{"hash":"87321956437991095","title":"Zinc ion transport and homeostasis","description":"The GO terms center on zinc handling: import across the plasma membrane, intracellular zinc ion homeostasis, and detoxification of zinc, plus responses to zinc ion availability and related metal ion transport. Although a couple development-related terms appear, the dominant signal is zinc uptake and maintenance, suggesting a cohesive zinc transport/homeostasis module.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":1},{"id":"GO:0006830","count":1},{"id":"GO:0006882","count":1},{"id":"GO:0044749","count":1},{"id":"GO:1903615","count":1}]},{"hash":"430684240720109500","title":"Unknown","description":"There is no coherent functional theme across the top GO terms; the terms span fungal development (ascospore formation), neural/glial differentiation, nuclear import, various muscle-related processes, myelination, calcium channel regulation, germ cell proliferation, NF-\u03baB signaling, and muscle differentiation regulation. With such diverse processes represented, there isn\u2019t a single representative function for the cluster. Therefore, Unknown. ","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030437","count":2},{"id":"GO:0048708","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0022011","count":2}]},{"hash":"1087028532013932027","title":"GPCR\u2013Adenylyl Cyclase Signaling and Blood Pressure","description":"GO terms point to GPCR-mediated activation of adenylate cyclase and subsequent cAMP signaling, with direct ties to vascular tone and blood pressure regulation and smooth muscle relaxation. The presence of both activation and negative regulation terms suggests a modulatory balance within this pathway. Some outlier terms may reflect broader annotations, but the core theme centers on GPCR\u2013adenylyl cyclase signaling affecting cardiovascular/muscle regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007190","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0060160","count":2}]},{"hash":"2096544570270339495","title":"Unknown","description":"The GO terms span GPCR signaling (dopamine receptor pathway, prostaglandin response), cell proliferation, DNA replication/repair, and tRNA processing\u2014no single cohesive function ties these proteins together in this small cluster, suggesting a mix of unrelated roles. ","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007191","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0008033","count":1},{"id":"GO:0072581","count":1}]},{"hash":"569958677452118540","title":"Dopaminergic GPCR Signaling Regulation","description":"The top GO terms cluster around regulation and modulation of dopamine receptor signaling, dopamine transport, and adenylate cyclase activity via GPCR pathways, suggesting a shared function in dopaminergic signaling control. Some terms touch on broader developmental or metabolic processes, but the dominant theme is GPCR-mediated regulation of dopamine signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060160","count":2},{"id":"GO:0090075","count":2},{"id":"GO:0007194","count":2},{"id":"GO:0016998","count":2},{"id":"GO:0040015","count":2}]},{"hash":"1196779064432434479","title":"Dopaminergic GPCR signaling modulation","description":"This cluster is dominated by GO terms tied to dopamine signaling and GPCR pathways, including negative regulation of dopamine receptor signaling, negative regulation of adenylate cyclase activity, and GPCR-mediated acetylcholine signaling, plus dopamine transport. Neural-related terms (cerebral cortex interneuron migration) further support a dopaminergic/neural signaling theme. A few terms (cell wall catabolic process, thymocyte differentiation) appear unrelated and may reflect annotation noise. Overall, the data point to modulation of dopaminergic GPCR signaling as the core function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060160","count":3},{"id":"GO:0090075","count":3},{"id":"GO:0007194","count":3},{"id":"GO:0016998","count":3},{"id":"GO:0040015","count":3}]},{"hash":"115660518373448256","title":"Broad-spectrum membrane transporters","description":"The cluster\u2019s GO terms are dominated by various transmembrane transport activities (phosphate, nitrite, sodium, xenobiotic, dehydroascorbic acid), suggesting a shared role in transporting diverse substrates across membranes. A few metabolic or regulatory terms appear, but they are peripheral to the main transporter theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904728","count":3},{"id":"GO:0070837","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0006004","count":3},{"id":"GO:0015707","count":3}]},{"hash":"1553321872225939092","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007010","count":1},{"id":"GO:0044205","count":1},{"id":"GO:0006207","count":1},{"id":"GO:0051491","count":1},{"id":"GO:0048678","count":1}]}]