[{"hash":"614923239977611699","title":"Thermogenesis and cardiovascular signaling","description":"The cluster shows strong enrichment for diet-induced thermogenesis and cellular response to temperature, along with electron transport chain activity and GPCR-activated adenylate cyclase signaling, all of which tie energy metabolism to cardiovascular functions such as heart development and blood pressure regulation. This combination suggests a module linking thermogenic energy expenditure with GPCR/cAMP-mediated heart and vascular signaling, even though some terms (pain perception, locomotion) may reflect broader tissue expression. Overall, the group appears to cluster around metabolic energy production coupled to cardiovascular signaling pathways.","confidence":"Medium","size":29,"edges":14,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":18},{"id":"GO:0019233","count":18},{"id":"GO:0071502","count":18},{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14}]},{"hash":"932635466136583443","title":"Unknown","description":"The GO terms span a broad and disparate set of cellular processes\u2014from ribosomal export and GTPase regulation to tight junction assembly and brain renin-angiotensin signaling\u2014without a single unifying function or connectivity. This makes it hard to assign a cohesive, specific label to the cluster; the proteins do not appear to form a common functional module.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0010513","count":2},{"id":"GO:0002035","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0043547","count":2}]},{"hash":"196638770134044146","title":"SHH/ROBO signaling in neural development","description":"The cluster is enriched for neural development and axon guidance terms, notably smoothened signaling (SHH pathway) and Roundabout signaling (ROBO), along with downstream ERK cascade regulation, and nervous system development and axon guidance. While kidney development and ossification show broader developmental roles, the strongest cohesive theme is neural development and axon pathfinding driven by SHH/ROBO signaling networks. Minor terms related to phospholipid homeostasis and mast cell chemotaxis appear as peripheral processes.","confidence":"High","size":29,"edges":213,"triangles":526,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007224","count":13},{"id":"GO:0035385","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0043552","count":13},{"id":"GO:0001822","count":13}]},{"hash":"897273402951555844","title":"Antibiotic stress response and DNA replication","description":"The prominent GO terms cluster around antibiotic interaction (nylon catabolic process; beta-lactamase activity regulation; beta-lactam antibiotic catabolic process; response to antibiotic) and DNA replication/cell cycle processes (DNA replication; centrosome cycle; positive regulation of nuclear events related to replication). Some terms appear less coherent with a single cohesive function (innate immune response; embryonic skeletal morphogenesis), likely annotation noise. Overall, the dominant theme combines antibiotic response with replication-related activities, justifying this label.","confidence":"Medium","size":29,"edges":17,"triangles":15,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019876","count":15},{"id":"GO:0033252","count":15},{"id":"GO:0030655","count":15},{"id":"GO:0046677","count":15},{"id":"GO:0045087","count":10}]},{"hash":"110052336472435658","title":"Deubiquitination in Immune Signaling","description":"Top GO terms center on deubiquitination of various ubiquitin linkages (K63, K29, K6, K33) and ubiquitin-dependent protein turnover, along with negative regulation of NOD2 and TLR5 signaling and LPS tolerance, plus germinal center formation regulation; together these point to a module of deubiquitinating control of innate immune signaling and adaptive responses.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":3},{"id":"GO:1990168","count":3},{"id":"GO:0070433","count":3},{"id":"GO:0044313","count":3},{"id":"GO:0071947","count":3}]},{"hash":"540550570718997850","title":"Immune transcription and cytokine signaling cluster","description":"Based on the top GO terms, this cluster is dominated by transcriptional regulation (RNA polymerase II\u2013mediated transcription) intertwined with immune signaling (cytokine production, macrophage differentiation, interleukin-4 response) and wound-healing processes. The strongest and most coherent theme appears to be transcriptional control during immune responses and cytokine signaling, with a few outlier terms (retina development, fatty acid homeostasis) likely reflecting broader or ancillary roles. Overall, the cluster seems to represent an immune-related transcriptional module.","confidence":"Medium","size":29,"edges":378,"triangles":3276,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":17},{"id":"GO:0035470","count":14},{"id":"GO:0030225","count":11},{"id":"GO:0006990","count":11},{"id":"GO:1990440","count":11}]},{"hash":"1179384612857727899","title":"Visual and auditory sensory development","description":"The top GO terms cluster around sensory perception (visual and sound) and retinal cone cell development, suggesting a focus on sensory system development. In addition, intracellular signal transduction and thrombin-activated receptor signaling, plus peptidyl-serine phosphorylation, point to signaling pathways that drive development and differentiation. Secretory granule localization and regulation of filopodium assembly hint at secretory and cytoskeletal remodeling involved in sensory cell maturation, with heart development indicating broader vertebrate developmental signaling. Overall, the cluster seems to group proteins tied to sensory system development and related signaling processes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0070493","count":5},{"id":"GO:0018105","count":4},{"id":"GO:0007605","count":4}]},{"hash":"1434259758812003377","title":"GPCR-Calcium Signaling in Nervous and Cardiovascular Systems","description":"This cluster is dominated by GO terms related to GPCR signaling activating adenylyl cyclase, calcium release, prostaglandin response, and cardiovascular regulation, with supporting terms for neural/sensory functions. The electron transport chain term is less central, suggesting the core theme is GPCR-mediated calcium signaling across nervous, sensory, and cardiovascular contexts.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":10},{"id":"GO:0010579","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0035025","count":8},{"id":"GO:0045777","count":8}]},{"hash":"1243051539520858606","title":"Unknown","description":"The top GO terms span both immune cell differentiation and skeletal muscle development, with additional unrelated processes like renal sodium absorption and ubiquitination regulation, showing no single cohesive function linking the proteins. This lack of a coherent theme means a concise, representative label is not apparent. ","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":5},{"id":"GO:0043380","count":5},{"id":"GO:0007519","count":5},{"id":"GO:0070294","count":5},{"id":"GO:1900477","count":5}]},{"hash":"291048918609212896","title":"Ubiquitination and Autophagy-Lysosome Trafficking","description":"The top terms point to ubiquitin-mediated protein modification and intracellular trafficking toward lysosomal degradation, including endosome-to-lysosome transport, reticulophagy, and Cvt pathway targeting. This suggests a shared role in protein turnover via ubiquitin signals and autophagy-lysosome pathways, with additional links to cytoskeletal signaling and immune pathways that often intersect with stress responses.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0030199","count":2},{"id":"GO:0008333","count":2},{"id":"GO:0032258","count":2}]},{"hash":"452318181992386880","title":"Spliceosome regulation and translation initiation","description":"The cluster is driven by GO terms centered on RNA processing via the spliceosome (regulation of alternative splicing, small-subunit processome assembly, mRNA export) and regulation of translation initiation (eIF4F complex assembly, IRES-dependent initiation, translational initiation regulation). Together, these terms indicate a cohesive module coordinating post-transcriptional RNA maturation with control of translation, justifying a label focused on spliceosome-regulated RNA processing and translation initiation.","confidence":"High","size":29,"edges":93,"triangles":211,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":11},{"id":"GO:0048026","count":11},{"id":"GO:0000381","count":9},{"id":"GO:0034462","count":8},{"id":"GO:0006378","count":8}]},{"hash":"1568197520868929261","title":"Unknown","description":"The GO terms span immune signaling (B cell receptor pathway), muscle development (skeletal muscle and muscle fiber development), core gene expression processes (DNA replication, DNA-templated transcription, mRNA export) and even xenobiotic/immune responses (response to interleukin-12, response to cocaine). This combination does not point to a single coherent biological process or function linking all proteins, suggesting the cluster reflects a mix of roles rather than a unified pathway.","confidence":"","size":29,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050853","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0007519","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0015074","count":4}]},{"hash":"457601307001164564","title":"Rho GTPase signaling and membrane dynamics","description":"This cluster is driven by GO terms centering on Rho/GTPase regulation (GO:0035023, GO:0043087) and broader GTPase activity, plus membrane-related processes such as plasma membrane repair and synaptic vesicle priming/assembly. The combination suggests coordinated control of cytoskeletal signaling and membrane trafficking in neural and vascular contexts, with additional but less central themes around angiogenesis and immune degranulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0001778","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0030948","count":5},{"id":"GO:0051092","count":4}]},{"hash":"712327440396457649","title":"Ribosome Biogenesis and Translation Initiation","description":"The top GO terms are dominated by translation-related processes, including translation reinitiation, formation of the translation preinitiation complex, and ribosome biogenesis, suggesting this cluster groups proteins involved in ribosome assembly and initiation of protein synthesis. A few terms touch on cell division and development, but the core signal points to components of the ribosome machinery and its regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002188","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0006378","count":6},{"id":"GO:0000747","count":5}]},{"hash":"1914468217208509425","title":"Ribosome Biogenesis and Cell Cycle","description":"The Top Terms include cell division and cell cycle (8 hits), ribosome biogenesis and ribosomal export/translation, and cell septum assembly, which together point to a theme of growth-related processes where ribosome production and protein synthesis support progression through the cell cycle and division.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0007049","count":8},{"id":"GO:1901001","count":7},{"id":"GO:1903833","count":7},{"id":"GO:0000747","count":7}]},{"hash":"246550064791386836","title":"Vertebrate organ development and neural signaling","description":"The cluster is enriched for developmental GO terms across heart, kidney, salivary gland and myoblast differentiation, plus nervous system terms like paranode localization and transmission of nerve impulse, and signaling pathways (Smoothened, adenosine receptor, STAT phosphorylation). This points to a module of proteins that coordinate development and neural signaling across multiple tissues rather than a single tissue function.","confidence":"Medium","size":29,"edges":231,"triangles":918,"max_degree":26,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":17},{"id":"GO:0002175","count":14},{"id":"GO:0045663","count":14},{"id":"GO:0034164","count":14},{"id":"GO:0060168","count":14}]},{"hash":"2004905959688953550","title":"ECM remodeling and cell adhesion","description":"Based on the top GO terms, the cluster centers on integrin-mediated signaling, regulation of extracellular matrix assembly, hyaluronan metabolism, and cell migration/adhesion, with supportive links to coagulation and complement activation. This combination points to extracellular matrix remodeling and adhesion dynamics as the core function of the proteins, consistent with tissue remodeling and migration processes (potentially wound healing).","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0007229","count":14},{"id":"GO:1901202","count":12},{"id":"GO:0070208","count":12},{"id":"GO:0007596","count":12},{"id":"GO:0006929","count":12}]},{"hash":"519087623599425366","title":"Cholesterol-Responsive Vesicle Transport","description":"The top GO terms point to cellular responses to cholesterol and ER-to-Golgi vesicle transport, with paranodal junction assembly suggesting membrane-associated signaling at specialized cell\u2013cell interfaces. While several terms are obsolete or reflect broad developmental or pathological contexts, the most coherent theme across the cluster is membrane-related trafficking and cholesterol-responsive signaling, justifying a label focused on vesicle transport linked to cholesterol. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071397","count":6},{"id":"GO:0030913","count":6},{"id":"GO:1902960","count":5},{"id":"GO:1902262","count":5},{"id":"GO:0060764","count":5}]},{"hash":"1177724676261930166","title":"Unknown","description":"The top GO terms span a wide and seemingly unrelated mix of processes (cell migration/adhesion, blood coagulation, extracellular matrix metabolism, plant-specific chlorophyll biosynthesis and stamen formation, dendrite regeneration, ubiquitin-dependent degradation). With no interactions (Edges 0, Triangles 0) and no common functional thread, there is no coherent theme tying these proteins together. I label it Unknown with None confidence.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0070208","count":9},{"id":"GO:0006929","count":8},{"id":"GO:0007596","count":7},{"id":"GO:0030212","count":7},{"id":"GO:0045123","count":7}]},{"hash":"931232875033240021","title":"Embryonic Eye Morphogenesis and Early Neural Development","description":"This cluster is dominated by GO terms tied to embryonic eye development (embryonic eye morphogenesis, camera-type eye development, in utero embryonic development, embryonic hindlimb morphogenesis) and neural-related membrane assembly (presynaptic and postsynaptic). While a couple terms are less related (osteoblast development, triglyceride homeostasis), the strongest theme is eye morphogenesis and early neural development, justifying the label.","confidence":"High","size":29,"edges":8,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0002076","count":5},{"id":"GO:0001701","count":5}]},{"hash":"1919060024652459945","title":"Sperm\u2013egg interaction and fertilization","description":"The top GO terms heavily point to fertilization-related functions: binding of sperm to the zona pellucida, regulation of the acrosome reaction, and processes tied to reproductive development and sperm activation (e.g., membrane ion transport and cell signaling), with supplementary terms about proteoglycan biosynthesis and secondary sexual characteristics that can relate to reproductive biology. While some terms (like blood coagulation) are less directly tied to fertilization, the dominant theme is sperm-egg recognition and fertilization-related processes, justifying a label around fertilization-related functions.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0075015","count":4},{"id":"GO:0018146","count":4},{"id":"GO:0008283","count":3},{"id":"GO:1902476","count":3}]},{"hash":"2084027092592977914","title":"Phosphorylation Signaling Regulation","description":"The cluster is enriched for terms centered on phosphorylation control (positive regulation of serine/threonine kinase activity, autophosphorylation, and dephosphorylation) and regulation of GTPase activity, pointing to phosphorylation-driven signaling networks. The presence of heart development and EMT terms suggests involvement in developmental signaling contexts, along with cell cycle regulation. Overall, a cohesive theme is modulation of signaling through phosphorylation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071902","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0031954","count":7},{"id":"GO:0006470","count":7},{"id":"GO:0007507","count":6}]},{"hash":"2289683544561136097","title":"Innate immune NF-\u03baB signaling and autophagy","description":"This cluster is dominated by terms related to innate immunity, defense against virus, and NF-\u03baB pathway regulation, plus autophagy. The convergence on innate antiviral responses and NF-\u03baB-driven signaling, with autophagy as a linked process, suggests a coherent innate immune/NF-\u03baB-autophagy module, despite a few outlier terms.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":7},{"id":"GO:0051607","count":7},{"id":"GO:0043123","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0006914","count":6}]},{"hash":"319827585179177357","title":"GPCR-cAMP Thermoregulation and Sensory Signaling","description":"This cluster is dominated by GO terms tied to activation of adenylate cyclase and GPCR signaling that stimulates adenylate cyclase, plus multiple terms related to temperature responses, thermogenesis, prostaglandin signaling, and sensory processes (pain perception and opsin/visual signaling). The inclusion of energy metabolism (electron transport chain) suggests a neuronal/thermogenic metabolism link, supporting a theme where GPCR-cAMP signaling modulates thermoregulation and broad sensory functions. Overall, the proteins appear to participate in a GPCR-driven signaling module impacting temperature-based responses and sensory pathways.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":20},{"id":"GO:0002024","count":19},{"id":"GO:0010579","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0022900","count":19}]},{"hash":"1807643533646474898","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000289","count":7},{"id":"GO:0002107","count":6},{"id":"GO:0000467","count":6},{"id":"GO:0010606","count":6},{"id":"GO:0006261","count":6}]},{"hash":"1554728292196308622","title":"Axon guidance and paranodal adhesion","description":"The top GO terms cluster around neural development and cell adhesion: axon extension and guidance, paranodal junction assembly, juxtaparanode localization, and glutamatergic synaptic transmission. The mix of adhesion-related terms (homophilic/heterophilic adhesion, substrate adhesion) supports a role in axon\u2013glia interactions and node/paranode organization, key for neural connectivity. Some terms like coronary artery morphogenesis or symbiont entry are less central but may reflect shared adhesion or trafficking aspects. Overall, the cluster likely represents neuronal adhesion and axon guidance components at nodes/paranodes and associated synaptic machinery.","confidence":"Medium","size":29,"edges":28,"triangles":1,"max_degree":5,"top_function":"wound healing","top_go_terms":[{"id":"GO:0014909","count":13},{"id":"GO:0071205","count":12},{"id":"GO:0030913","count":12},{"id":"GO:0048846","count":11},{"id":"GO:0060982","count":11}]},{"hash":"667530671504355571","title":"Ubiquitin-dependent antiviral innate immune signaling","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes and various ubiquitination types (K63-linked, K6-linked) together with defense against virus and innate immune response, plus NF-\u03baB activation and regulation of apoptosis. This pattern points to a group of proteins coordinating antiviral immunity through ubiquitin-mediated signaling, including inflammatory/NF-\u03baB pathways, with some links to immune cell processes like V(D)J recombination. Overall, the shared function appears to be ubiquitin-regulated antiviral innate immune signaling.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0051607","count":9},{"id":"GO:0045087","count":9},{"id":"GO:0070535","count":9},{"id":"GO:0042981","count":9}]},{"hash":"1020514351307597603","title":"Immune activation and inflammatory signaling","description":"Based on the top GO terms, the cluster is enriched for immune-related processes such as defense response to Gram-positive bacteria, interleukin-8 production, T cell costimulation, and lipopolysaccharide signaling, indicating a cohesive theme around immune activation and inflammatory signaling. While a couple of terms relate to neural development and myelination, these are less central to the dominant immune-associated terms observed. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0045416","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0031295","count":3}]},{"hash":"992530628736080151","title":"Epigenetic Regulation and Autophagy","description":"The top GO terms point to epigenetic control (epigenetic programming of gene expression, DNA demethylation regulation) together with autophagy, and several lines of negative regulation affecting signaling and protein turnover. This suggests a cluster centered on regulatory mechanisms that modulate gene expression and cellular quality control pathways, rather than a single straightforward pathway. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043569","count":7},{"id":"GO:0006914","count":5},{"id":"GO:1900458","count":5},{"id":"GO:2000059","count":5},{"id":"GO:0060669","count":5}]},{"hash":"1526963061300439236","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":16},{"id":"GO:0045087","count":16},{"id":"GO:1902187","count":15},{"id":"GO:0007014","count":15},{"id":"GO:2000637","count":15}]},{"hash":"1683265699847376394","title":"Innate Immune Activation in Macrophages and Dendritic Cells","description":"This cluster is dominated by GO terms tied to innate immunity: defense against Gram-positive bacteria, macrophage activation, and detection of lipopolysaccharide, plus regulation of dendritic cell cytokine production. These suggest a shared role in innate immune sensing and activation of antigen-presenting cells. Additional terms like pinocytosis and signaling pathways (e.g., Wnt) can reflect endocytic uptake and signal transduction processes common in immune cell activation, reinforcing the central theme of innate immune response.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0014728","count":3}]},{"hash":"1452459939397789852","title":"Unknown","description":"GO terms span diverse areas including transport of amino acids and glucose, glycosylation, lens development, grooming behavior, and immune activation. These appear unconnected functionally, and the absence of edges supports a non-cohesive cluster. Therefore no coherent function label; Unknown.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080144","count":2},{"id":"GO:0034488","count":2},{"id":"GO:0007625","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0060905","count":2}]},{"hash":"1591019183404609213","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0007014","count":7},{"id":"GO:2000637","count":7},{"id":"GO:0061158","count":7},{"id":"GO:1902187","count":7}]},{"hash":"2108514924660782479","title":"Antiviral Innate Immune Signaling","description":"The cluster centers on innate immune response and defense against viruses, with terms highlighting antiviral defense and viral defense pathways. It also features NF-kappaB-related transcription regulation, TNF and IL-17 signaling, and host suppression of viral release, all pointing to a coherent antiviral immune signaling theme. While there are accessory terms related to RNA metabolism, peptide processing, and cytoskeletal regulation, the dominant pattern is innate antiviral defense and cytokine signaling.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":18},{"id":"GO:0051607","count":17},{"id":"GO:0051092","count":17},{"id":"GO:0072089","count":16},{"id":"GO:0010586","count":16}]},{"hash":"1398806933923420986","title":"Actin Cytoskeleton Remodeling and Protrusion Formation","description":"Top GO terms indicate strong enrichment for actin cytoskeleton organization, lamellipodium/filopodium assembly, and regulation of Rho signaling, with additional signals for endosomal transport and cell-cycle regulation. This combination suggests a cohesive set of proteins involved in dynamic actin remodeling to form membrane protrusions (lamellipodia/filopodia) and associated trafficking, i.e., cell migration and related processes.","confidence":"High","size":28,"edges":330,"triangles":2399,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0046847","count":2},{"id":"GO:1903526","count":2},{"id":"GO:0030036","count":2}]},{"hash":"325564222453620009","title":"Synaptic plasticity and actin remodeling","description":"This cluster is enriched for GO terms tied to long-term synaptic potentiation and synapse structural plasticity, plus TRK receptor signaling, small GTPase\u2013mediated signaling, and actin filament branching, all pointing to regulation of synaptic architecture through cytoskeletal dynamics and signaling; podosome assembly and substrate adhesion\u2013dependent spreading further emphasize adhesion\u2013driven cytoskeleton remodeling that can support synaptic remodeling and neuronal communication.","confidence":"Medium","size":28,"edges":71,"triangles":68,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900273","count":4},{"id":"GO:0048011","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0034260","count":3}]},{"hash":"674960724193464980","title":"Membrane Nutrient Transporters","description":"The top GO terms are dominated by transport of small molecules across membranes (D-glucose transmembrane transport, myo-inositol transport, pantothenate transport, biotin transport) and sodium export, suggesting a cluster of transporter proteins responsible for uptake and efflux of nutrients and cofactors. While there are also terms like protein ubiquitination and mRNA processing present, the clear transport theme provides a cohesive function for this cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0006397","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0008292","count":3}]},{"hash":"418136281298056492","title":"Muscle Development and Calcium Signaling","description":"Based on the top GO terms, the cluster centers on skeletal and cardiac muscle development (skeletal muscle fiber development; skeletal muscle tissue development; positive regulation of cardiac muscle hypertrophy in response to stress) and calcium-dependent signaling (detection of calcium ion; calcineurin-NFAT signaling cascade). This suggests a cohesive theme around muscle formation/activity governed by calcium/NFAT pathways. Some terms like Schwann cell development and epithelial-to-mesenchymal transition may reflect broader developmental roles of these proteins, but the strongest signal is muscle-related differentiation and Ca2+-mediated signaling.","confidence":"Medium","size":28,"edges":67,"triangles":12,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":6},{"id":"GO:1903244","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0050853","count":4}]},{"hash":"2094884902478154823","title":"Ubiquitin-Proteasome Degradation and Immune-Circadian Regulation","description":"The dominant GO terms point to ubiquitin-dependent proteolysis (including SCF-mediated pathways and ERAD) and polyubiquitination, i.e., protein turnover. The additional terms connect this core to innate immune responses and circadian rhythm regulation, suggesting a cohesive cluster of proteins that tie proteostasis to immune signaling and clock control.","confidence":"High","size":28,"edges":10,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":23},{"id":"GO:0031146","count":14},{"id":"GO:0042752","count":14},{"id":"GO:0000209","count":12},{"id":"GO:0051607","count":11}]},{"hash":"1254495453098247901","title":"Developmental transcription and chromatin regulation","description":"This cluster centers on transcriptional regulation and chromatin state control (negative regulation of RNA Pol II transcription, histone methylation control, heterochromatin formation) with several terms tied to development (brain and gonad development, fertilization). The combination suggests proteins involved in regulating gene expression during development through chromatin remodeling and transcriptional control, rather than a single pathway. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0007338","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0061086","count":3},{"id":"GO:0008584","count":3}]},{"hash":"1115321471853373366","title":"B and T cell receptor signaling and differentiation","description":"This cluster\u2019s top GO terms are dominated by adaptive immune processes: B cell receptor signaling, positive regulation of dendritic cell differentiation, and regulation of memory T cell differentiation, along with the ERK/MAPK cascade relation and GTPase activity regulation. These together point to lymphocyte activation and differentiation as the core theme, with some outliers (morphine response, renal/skeletal muscle terms) that are less central to the main function. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0070374","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0043547","count":3},{"id":"GO:2001200","count":3}]},{"hash":"27620581589769278","title":"Innate Immune Response and Cell Division","description":"These proteins are enriched for innate immune response and defense against Gram-positive bacteria, indicating an immune-related function. There are also significant counts for cell division and mitotic cell cycle, suggesting involvement in proliferation. While some terms relate to nervous system development and apoptotic clearance, these are less dominant, so the name focuses on the two strongest themes: innate immunity and cell division.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0051301","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0043277","count":5}]},{"hash":"996928976332547555","title":"Immune signaling and vascular remodeling","description":"This cluster shows strong enrichment for immune-related processes (adaptive immune response; complement activation via the lectin pathway) alongside vascular remodeling activities (angiogenesis; endothelial cell migration; vasoconstriction; plasminogen activation) and signaling events (ERK cascade; receptor tyrosine kinase activation; protein localization to the cell surface). The combination suggests proteins that mediate immune modulation of vascular function and remodeling, with some neuronal signaling terms likely reflecting shared signaling pathways rather than a neuronal-specific function. Confidence: High","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0045907","count":11},{"id":"GO:0051968","count":10},{"id":"GO:0001867","count":10},{"id":"GO:0070374","count":9},{"id":"GO:0002250","count":9}]},{"hash":"161800931870964282","title":"Ubiquitin-Dependent NF-kappaB Immune Signaling","description":"The dominant GO terms emphasize ubiquitin-mediated protein degradation and autoubiquitination (including K6-linked ubiquitination), coupled with innate immune response and NF-kappaB activation, as well as downstream inflammatory signaling (IL-17) and apoptosis regulation. This points to a cohesive set of proteins that regulate immune signaling through ubiquitin tagging and NF-kappaB pathways, with impacts on cell fate during inflammation.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0051865","count":10},{"id":"GO:0051092","count":9},{"id":"GO:0045087","count":8},{"id":"GO:0035372","count":8}]},{"hash":"1612372434328476780","title":"B cell signaling and actin remodeling","description":"Top GO terms indicate immune signaling (B cell receptor signaling pathway) together with small GTPase/Rac-mediated signaling and cytoskeletal assembly (lamellipodium and microspike), suggesting a theme of immune signal transduction linked to actin remodeling. Some terms appear broader or obsolete, but the core pattern points to proteins involved in B cell signaling and cytoskeletal dynamics during lymphocyte activation and movement.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0050853","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0007264","count":4}]},{"hash":"2162145167219655646","title":"Transcription Regulation and Protein Turnover","description":"The cluster centers on processes that control gene expression and protein homeostasis, including DNA-templated transcription, SCF-ubiquitin proteasomal degradation, and protein polyubiquitination, along with TORC1 signaling and regulation of GTPase activity. Additional hints like mRNA transport and phosphatase activity (peptidyl-serine dephosphorylation) suggest coordinated regulation of transcription and protein turnover in response to cellular signals and stress (e.g., cadmium ion response), rather than a single, narrow function.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071276","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0051028","count":3},{"id":"GO:0038202","count":3},{"id":"GO:0031146","count":3}]},{"hash":"509885231400405609","title":"Auditory and neural development","description":"Proteins in this cluster are enriched for GO terms related to inner ear development, sensory perception of sound, brain development, and neuron cell-cell adhesion, pointing to a cohesive theme of neural-sensory development. Additional terms like roof of mouth development and primitive streak formation suggest broader embryonic developmental roles. The absence of edges doesn't negate this interpretation, but the mix of sensory-neural and craniofacial/developmental terms best supports an overall \u201cauditory and neural development\u201d label. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0030168","count":6},{"id":"GO:0007626","count":5},{"id":"GO:0060021","count":5}]},{"hash":"674085082156291585","title":"GPCR-AC signaling and energy metabolism","description":"The top GO terms cluster around GPCR signaling that activates adenylate cyclase, alongside mitochondrial energy production and thermogenesis, with vascular, inflammatory, and calcium signaling components. This suggests a theme where GPCR-mediated signaling modulates energy metabolism and related physiological responses (thermogenesis, blood pressure) together with inflammatory and calcium signaling aspects.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":22},{"id":"GO:0022900","count":22},{"id":"GO:0007190","count":22},{"id":"GO:0045777","count":22},{"id":"GO:0002024","count":20}]},{"hash":"28864715949897929","title":"Cardiac development and signaling with stress responses","description":"The cluster is enriched for heart development and angiogenesis terms, suggesting a cardiac/vascular focus. Additional terms related to glucocorticoid response, cAMP signaling, muscle activity, redox balance, and cell cycle/proliferation point to broader signaling and growth/stress response programs that couple cardiac development with metabolic and mitotic regulation. Overall, the data support a cohesive label around cardiac development and associated signaling pathways.","confidence":"High","size":28,"edges":50,"triangles":127,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0051384","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0000086","count":4}]},{"hash":"1263284868876497151","title":"Immuno-vascular inflammation and coagulation","description":"These terms point to an immune-vascular inflammatory program: innate immune activation via lectin pathways and C-type lectin signaling, adaptive immunity, angiogenesis and endothelial migration, vasoconstriction, ERK signaling, and coagulation. The proteins likely participate in coordinating inflammation, blood vessel remodeling, and clot formation.","confidence":"High","size":28,"edges":59,"triangles":73,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0002223","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0043536","count":5}]},{"hash":"399420304324093948","title":"Neurovascular inflammation and remodeling","description":"This cluster shows enrichment for inflammation and vascular remodeling terms: response to lipopolysaccharide, blood coagulation, regulation of fibrinogen, sprouting angiogenesis, smooth muscle cell migration and proliferation. There are also neuronal terms related to synapse assembly and glutamatergic transmission, which may reflect multifunctional proteins or cross-talk between neural and vascular processes. Overall, the dominant pattern points to neurovascular inflammatory remodeling rather than a single, isolated function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0051965","count":6},{"id":"GO:0090050","count":6},{"id":"GO:0051968","count":6},{"id":"GO:0098869","count":6}]},{"hash":"2002816453669145067","title":"Angiogenesis and ECM Remodeling","description":"This cluster is dominated by GO terms related to angiogenesis, cell-matrix adhesion, and collagen fibril organization, indicating proteins involved in blood vessel formation and extracellular matrix remodeling. ERK signaling terms support endothelial proliferation and migration, while metabolic terms like triglyceride homeostasis and leptin response may reflect vascular\u2013metabolic crosstalk. Overall, the functions cohere around vascular growth and ECM remodeling rather than a single enzymatic activity.","confidence":"High","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007160","count":10},{"id":"GO:0045766","count":9},{"id":"GO:0001525","count":9},{"id":"GO:0043536","count":9},{"id":"GO:0070374","count":9}]},{"hash":"461595250255401044","title":"Innate antiviral defense and NF-kappaB signaling","description":"The cluster is dominated by GO terms related to innate immunity and antiviral defense (defense response to virus, innate immune response) and inflammatory signaling (inflammatory response, positive regulation of canonical NF-kappaB signal transduction, NLRP3 inflammasome assembly). A few terms about neuronal processes (synapse assembly, dopamine receptor signaling) may reflect neuroimmune crosstalk, but the core pattern centers on antiviral innate immunity and NF-kB\u2013mediated inflammation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051607","count":10},{"id":"GO:0045087","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0051092","count":9},{"id":"GO:0043123","count":9}]},{"hash":"883958445279519344","title":"Neurovascular development and axon guidance","description":"This cluster combines vascular development processes (coronary artery morphogenesis, vasoconstriction, smooth muscle migration, blood coagulation, plasminogen activation) with neuronal development and axon connectivity (axon extension, paranodal junction assembly, juxtaparanodal protein localization, and glutamatergic synaptic transmission), suggesting a cohesive role in coordinated neurovascular patterning and axon guidance at nerve\u2013vessel interfaces.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060982","count":6},{"id":"GO:0048846","count":6},{"id":"GO:0030913","count":5},{"id":"GO:0045907","count":5},{"id":"GO:0014909","count":5}]},{"hash":"78493115111727274","title":"Innate immune signaling and NF-\u03baB regulation","description":"The cluster is enriched for innate immune response, defense against virus, MHC I biosynthesis, and NOD2 signaling, with involvement of K63-linked ubiquitination and NF-\u03baB regulation. These points together suggest a core role in innate immune signaling and NF-\u03baB\u2013mediated transcription, with a few developmental terms likely representing annotation noise. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0032088","count":5},{"id":"GO:0045345","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0070431","count":4}]},{"hash":"2238700587792117462","title":"Axon Guidance and Neuronal Development","description":"Top GO terms indicate a cohesive theme of neural connectivity, with multiple entries for axon guidance (retinal ganglion cell, commissural neuron), dendrite development, and ERK signaling, plus extracellular matrix organization that supports guidance and synaptic wiring. Inflammatory response and environmental enrichment terms may reflect activity-dependent plasticity, but the core signal centers on neural development and axon pathfinding.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045987","count":3},{"id":"GO:0006954","count":2},{"id":"GO:0060666","count":2},{"id":"GO:0048843","count":2},{"id":"GO:0016358","count":2}]},{"hash":"1404859924854415578","title":"Regulation of immune signaling and secretion","description":"The cluster shows enrichment in immune-related terms (adaptive immune response, response to LPS) along with signals regulating secretion and signaling (calcium release, hormone secretion, ERK cascade) and ubiquitination, suggesting a network coordinating immune signaling and regulated secretion. Some outliers exist (reproductive process, osteoclast differentiation), but the core theme is immune signaling and secretion regulation.","confidence":"Medium","size":27,"edges":155,"triangles":351,"max_degree":26,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051281","count":6},{"id":"GO:0046887","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0032496","count":6},{"id":"GO:0048609","count":6}]},{"hash":"1711465570401182155","title":"RNA processing and translation initiation","description":"The cluster shows enrichment in small-subunit processome assembly, mRNA polyadenylation/export, and assembly of the translation initiation machinery (eIF4F; IRES-dependent initiation), plus translational regulation and regulatory ncRNA silencing, indicating a coherent RNA metabolism/translation control module.","confidence":"High","size":27,"edges":18,"triangles":2,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0034462","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0097010","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006406","count":3}]},{"hash":"1930048775975905631","title":"Chromosome maintenance and mitosis machinery","description":"This cluster is dominated by GO terms tied to DNA replication, mitotic cell cycle, centromere-associated chromatin assembly (CENP-A), cell division, and microtubule severing, pointing to proteins involved in chromosome maintenance and progression through mitosis. A few terms related to ER transport and defense responses are less central or potentially incidental, but do not override the core signal. Overall, the set most plausibly represents a chromosomal maintenance/mitosis module.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0070651","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0061641","count":4}]},{"hash":"835832520264108416","title":"Unknown","description":"The top terms cover distinct domains: immune-related processes (response to fungal origin, germinal center formation, follicular dendritic cell differentiation, IL-12 regulation, NF-kappaB activity) and cardiac/mechanical terms (SA node signaling, response to mechanical stimulus, muscle stretch, SA node action potential regulation) plus hepatocyte apoptosis. With no shared core function or pathway and no edges linking proteins, there is no coherent theme to label a specific function for this cluster beyond a broad, mixed set of roles.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002238","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0035994","count":2},{"id":"GO:0045083","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1975457535528085025","title":"Unknown","description":"The top GO terms are highly diverse, spanning sensory perception of sound, RNA processing (splicing, mRNA capping), nucleolar localization, protein complex formation (tetramerization), microtubule-based movement, acrosome reaction, and signaling regulation, with some terms marked obsolete. There is no coherent, shared biological process linking these proteins, so a single interpretable function label isn\u2019t evident.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0007340","count":2},{"id":"GO:1902570","count":2}]},{"hash":"1734169919207809513","title":"Actin-driven cell motility and endocytosis","description":"The terms cluster around dynamic actin remodeling (cytoskeleton reorganization, actin filament branching, ruffle and podosome assembly), endocytosis, and regulation of cell shape/polarity and adhesion, with connections to T cell signaling and synaptic plasticity. These together point to a theme of actin-driven processes governing cell movement, membrane trafficking, and polarity across immune and neuronal contexts.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":9},{"id":"GO:0006897","count":9},{"id":"GO:0071963","count":9},{"id":"GO:1900026","count":8},{"id":"GO:0051835","count":8}]},{"hash":"1261632578915638462","title":"Neural GPCR-cAMP signaling and thermogenic regulation","description":"The cluster\u2019s top GO terms are dominated by GPCR signaling activating adenylate cyclase and cAMP production, plus calcium release and neural-associated processes (pain perception, fear), with thermogenesis and energy-related terms (diet-induced thermogenesis, electron transport chain). This suggests a core theme around GPCR-cAMP signaling in neural and metabolic regulation, including thermogenic responses.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0035025","count":12},{"id":"GO:0007190","count":12}]},{"hash":"843496211267481587","title":"Innate immune activation and leukocyte recruitment","description":"Dominant terms indicate activation of innate immune pathways, especially complement activation via the lectin pathway, leukocyte tethering/rolling, phagocytosis recognition, basophil activation, and platelet activation, consistent with immune cell recruitment and pathogen response. A few terms related to cartilage condensation and metanephric development appear less related to immunity and may reflect broader GO annotations. Overall, the cluster seems to group proteins involved in initiating and coordinating innate immune responses and leukocyte interactions.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":18},{"id":"GO:0071226","count":15},{"id":"GO:0001502","count":14},{"id":"GO:0050901","count":14},{"id":"GO:0072218","count":14}]},{"hash":"1360224308501705849","title":"Cytoskeleton Dynamics and Vesicle Trafficking","description":"The top GO terms cluster around tubulin complex assembly, small GTPase signaling, mitochondrial fission, and ER-to-Golgi vesicle transport, all features of cytoskeleton remodeling and vesicular trafficking. Terms like regulation of filopodium assembly and nervous system development further support a theme of actin/microtubule dynamics connected to membrane trafficking, with broader relevance to organelle maintenance and phospholipid homeostasis.","confidence":"Medium","size":27,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007021","count":5},{"id":"GO:0007264","count":4},{"id":"GO:0000266","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0007399","count":4}]},{"hash":"2229363811679371655","title":"Immune Activation and Signaling","description":"The top GO terms cluster around innate and adaptive immune responses: responses to lipopolysaccharide and Gram-positive bacteria, T cell receptor signaling, GM-CSF\u2013stimulated pathways, and Rho-mediated signal transduction, all pointing to immune cell activation and inflammatory signaling. Positive regulation of angiogenesis may reflect immune-related tissue remodeling; a single term about dendritic spine morphogenesis is less central. Overall, the dominant theme is immune activation and signaling.","confidence":"High","size":27,"edges":116,"triangles":198,"max_degree":22,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0045766","count":25},{"id":"GO:0071222","count":25},{"id":"GO:0050830","count":25},{"id":"GO:0046827","count":25},{"id":"GO:0050852","count":25}]},{"hash":"763623037830852169","title":"Epidermal morphogenesis and angiogenesis signaling","description":"The top GO terms point to skin-related development, with keratinocyte proliferation and hair follicle morphogenesis, along with endothelial tube lumen extension indicating angiogenesis. Together these suggest a theme of epidermal morphogenesis coupled with vascular formation. Other terms (autophagy, protein deglycosylation, transcription by RNA pol III) imply broader cellular remodeling that can accompany tissue development, but the skin/vascular developmental cluster is the most coherent common thread.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":2},{"id":"GO:0006517","count":2},{"id":"GO:0097498","count":2},{"id":"GO:0010838","count":2},{"id":"GO:0031069","count":2}]},{"hash":"1266482462127304163","title":"Nuclear transcription and growth signaling","description":"These terms cluster around transcriptional activity (DNA-templated transcription, mRNA transport) and growth/regulatory signaling (positive regulation of serine/threonine kinase activity, GTPase activity, autophosphorylation, TGF-beta response), plus processes tied to the cell cycle and ribosome biogenesis. This suggests a group of proteins that coordinate transcription with cell growth, division, and stress responses such as hypoxia.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0071456","count":5},{"id":"GO:0051028","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0000278","count":5}]},{"hash":"1129292709411949212","title":"Coagulation and vascular-immune signaling","description":"This cluster features GO terms tied to blood coagulation, complement activation, leukocyte tethering/rolling, and sprouting angiogenesis, suggesting a common theme of coagulation and immune-vascular interaction during vessel remodeling; a few outlier terms are likely noise.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0090050","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0050873","count":4},{"id":"GO:0006590","count":3}]},{"hash":"1363296462571200027","title":"Mitochondrial apoptotic regulation","description":"The dominant terms describe checkpoints in apoptosis linked to mitochondria: cytochrome c release, regulation of mitochondrial depolarization, and negative regulation of apoptotic pathways (including extrinsic signaling). Secondary terms about endothelial activation and lipid metabolism suggest broader cellular context but do not override the central theme of mitochondrial apoptosis control.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043154","count":5},{"id":"GO:0001836","count":5},{"id":"GO:2001240","count":5},{"id":"GO:0051902","count":5},{"id":"GO:0042118","count":3}]},{"hash":"2104372618848150986","title":"Unknown","description":"The GO terms are highly heterogeneous (bone development, immune responses, vesicular transport, metabolism, neuromuscular processes, and host\u2013symbiont interactions) with no single dominant function linking the proteins, so a cohesive label isn\u2019t supported.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030282","count":4},{"id":"GO:0035456","count":3},{"id":"GO:0099638","count":3},{"id":"GO:0044381","count":3},{"id":"GO:0046597","count":3}]},{"hash":"2055616590723341973","title":"TLR4-NF-kappaB antiviral Th1 signaling","description":"A cluster dominated by toll-like receptor 4/TRAM-associated NF-kappaB and JNK pathway terms, linked to antiviral defense and Th1-type immune responses. The GO terms point to upstream innate sensing of pathogens (TLR4 signaling, NF-kappaB activation) and downstream adaptive skewing (IL-12 response, Th1, and suppression of IL-23), supporting a cohesive antiviral, Th1-promoting signaling module.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":14},{"id":"GO:0071260","count":12},{"id":"GO:0043123","count":12},{"id":"GO:0046330","count":11},{"id":"GO:0051607","count":11}]},{"hash":"71163528996116225","title":"Autophagy and Epigenetic Regulation","description":"The cluster is enriched for autophagy (GO:0006914) and epigenetic programming of gene expression (GO:0043045), with multiple entries mentioning negative regulation across various regulatory processes (ubiquitin-dependent proteolysis, DNA demethylation, NF-kappaB activity, etc.) and microtubule-associated protein localization. This points to a set of proteins involved in managing cellular quality control and epigenetic control, plus broader regulatory modulation, rather than a single linear pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":9},{"id":"GO:0035372","count":9},{"id":"GO:1900458","count":8},{"id":"GO:2000059","count":8},{"id":"GO:0060669","count":8}]},{"hash":"2196013909106508828","title":"Neural development and angiogenesis regulation","description":"This cluster is dominated by GO terms related to nervous system development (including olfactory bulb development, myelination, and general neural development) and to angiogenesis regulation (both positive and negative). The co-occurrence of neural maturation and vascular signaling suggests a neurovascular development theme, with a few immune/platelet-related terms likely reflecting broader neuro-immune interactions. Confidence: High","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0001525","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0042552","count":2}]},{"hash":"1472529073314759521","title":"Eye development and immune signaling regulators","description":"This cluster combines strong signals for camera-type eye development and multicellular organism development with numerous terms related to immune defense (defense response to virus, dsRNA response, T cell chemotaxis) and general regulatory processes (ubiquitin-dependent proteolysis, mitochondrial fission, protein targeting to membranes). The proteins likely play roles in developmental regulation that also modulate immune and cellular signaling pathways, rather than a single narrowly defined function.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007275","count":13},{"id":"GO:0042787","count":12},{"id":"GO:0043010","count":12},{"id":"GO:0032464","count":12},{"id":"GO:0002230","count":12}]},{"hash":"2293287230011616685","title":"Unknown","description":"The GO terms span host-symbiont dormancy, stress response, multiple biosynthetic pathways (biotin, menaquinone, antibiotic), lysosomal acidification, protein depalmitoylation, and neuronal processes (brain development, synaptic vesicle endocytosis), which do not reveal a single coherent function for the cluster. This functional heterogeneity suggests the cluster is not functionally cohesive, so Unknown with no confidence is appropriate.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0085014","count":8},{"id":"GO:0006950","count":8},{"id":"GO:0007420","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0055114","count":4}]},{"hash":"1183437420164202350","title":"Angiogenesis and vascular cell migration signaling","description":"The GO terms point to vascular development and cell movement, with VEGF and HGF receptor signaling, integrin-mediated signaling, smooth muscle/fibroblast migration, and coronary artery morphogenesis; a subset of terms also touches neuronal guidance and axon-related localization, suggesting shared adhesion/signaling pathways. Overall, the cluster seems centered on angiogenesis and vascular remodeling coupled with migratory signaling, with some overlap into guidance mechanisms.","confidence":"Medium","size":27,"edges":9,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0014909","count":6},{"id":"GO:0007229","count":5},{"id":"GO:0048010","count":5},{"id":"GO:0010763","count":5},{"id":"GO:0051965","count":5}]},{"hash":"339203463766075635","title":"Multisystem organ and nervous system morphogenesis","description":"The enriched terms point to developmental and morphogenetic processes across several organs (nervous system: axon guidance, paranodal junctions; cardiovascular: coronary artery and aortic valve morphogenesis; kidney: Loop of Henle development). Additional signals touch adipose differentiation, supporting a broad theme of multisystem development rather than a single pathway. The lack of edges suggests grouping by GO annotations rather than direct interactions, so this label captures a shared developmental function across proteins. Note: one term is obsolete and not informative.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0071205","count":8},{"id":"GO:0048846","count":8},{"id":"GO:0030913","count":8},{"id":"GO:0014909","count":8}]},{"hash":"1194033193886103925","title":"Neurovascular Inflammation and Oxidative Stress","description":"This cluster shows strong enrichment for oxidative stress response, inflammatory signaling (TNF, LPS), hypoxia response, and prostaglandin synthesis, along with CNS vascular processes like blood-brain barrier maintenance and blood pressure regulation, pointing to a neurovascular inflammatory/oxidative stress program.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0006979","count":6},{"id":"GO:0035633","count":6},{"id":"GO:0009750","count":6},{"id":"GO:0071456","count":6}]},{"hash":"840991916924496257","title":"Unknown","description":"The top GO terms span diverse themes\u2014cell growth, motility, sensory perception, calcium transport, metabolism (chitin and polysaccharide catabolism), spindle assembly, and cell cycle regulation\u2014without a single unifying function. This heterogeneity makes it hard to assign a coherent label that accurately represents the cluster.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":4},{"id":"GO:0007626","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0000272","count":3}]},{"hash":"890432369465975591","title":"Vascular development and BMP-driven osteogenesis","description":"The top GO terms point to vascular biology (blood/hemolymph coagulation, endothelial activation and differentiation, cell-matrix adhesion, angiogenesis) and to BMP signaling regulation with osteoblast differentiation, suggesting a coherent theme around BMP-mediated coordination of angiogenesis and bone morphogenesis. Some terms are species-specific (otolith tethering, hemolymph coagulation) but the dominant signal ties vascular development to skeletal bone formation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0002043","count":5},{"id":"GO:0030513","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0042118","count":4}]},{"hash":"502225275935173570","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":14},{"id":"GO:0007014","count":14},{"id":"GO:2000637","count":14},{"id":"GO:0061158","count":14},{"id":"GO:0006914","count":9}]},{"hash":"1544352717951249259","title":"Neural Development and Tissue Morphogenesis","description":"This cluster combines neural development processes (axon fasciculation/extension, myelination, synapse assembly) with broad tissue morphogenesis activities (collagen fibril organization, organ development such as metanephric tubules, lymph vessel and lung connective tissue development, nipple morphogenesis). The shared theme appears to be developmental wiring and remodeling across multiple tissues, with a strong emphasis on neural connectivity.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007413","count":5},{"id":"GO:0072237","count":5},{"id":"GO:0072287","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0036303","count":5}]},{"hash":"884311750556356281","title":"Innate immune signaling in skeletal muscle","description":"The top GO terms cluster around innate immune activation via TLR/MyD88 and NF-\u03baB, TNF production, and LPS response, all pointing to inflammatory signaling in muscle context; accompanying BMP/Wnt/vasculature terms suggest muscle tissue remodeling during inflammatory or developmental processes.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048741","count":3},{"id":"GO:0032760","count":3},{"id":"GO:0002755","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0031663","count":3}]},{"hash":"383195401217607808","title":"Neural development and synaptic signaling","description":"This cluster clearly centers on nervous system development and synaptic function, with terms about neural development, axon midline choice, synapse structure/activity regulation, and ionotropic glutamate receptor signaling. Additional terms touch on neural morphogenesis and neuron-specific protein/homeostasis processes (calcium homeostasis in ER, amyloid formation), reinforcing a neural/neuronal signaling theme, despite a few broader morphogenesis terms. Overall, the set seems best described by a neural development and synaptic signaling theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":1},{"id":"GO:0016199","count":1},{"id":"GO:0060670","count":1},{"id":"GO:0007399","count":1},{"id":"GO:1990000","count":1}]},{"hash":"1240549254836113506","title":"TLR-Mediated Innate Immunity","description":"This cluster is dominated by Toll-like receptor signaling and innate immune response terms (TLR2/4, LPS signaling, inflammatory response, defense against Gram-positive bacteria, IL-8 production), indicating a cohesive module of innate immune activation and inflammation. Some terms like angiogenesis and synapse-related processes may reflect broader inflammatory or neuroimmune contexts, but the core signal centers on TLR-driven innate immunity.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":13},{"id":"GO:0016525","count":13},{"id":"GO:0071260","count":13},{"id":"GO:0051965","count":13},{"id":"GO:0031663","count":13}]},{"hash":"273266344728802262","title":"Cell adhesion and tissue development","description":"This cluster centers on processes of cell-cell adhesion, migration, and tissue morphogenesis (skin and smooth muscle development), with supporting themes of cytoskeletal signaling (Rho), membrane protein remodeling, and post-translational modifications. While some terms (like symbiont entry) are more context-specific, the dominant signals point to adhesive and developmental functions shaping tissues.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051044","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0048745","count":2},{"id":"GO:0035024","count":2}]},{"hash":"68831714649027864","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0019076","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0010587","count":2},{"id":"GO:0071031","count":2}]},{"hash":"1296186224783632825","title":"Neuronal Development and Signaling","description":"The cluster shows enrichment for neural and sensory-related processes: positive regulation of ERK1/ERK2 signaling, nervous system development, visual perception, opsin-mediated signaling, and positive regulation of synapse assembly, all pointing to neuronal differentiation, synaptic maturation, and sensory pathway signaling. Additional terms like integrin signaling and regulation of GTPase activity support cytoskeletal remodeling and cell\u2013matrix interactions common in developing neurons; a couple of terms (heart development, defense response) are broader or less specific but do not override the overall neural-centric theme.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0051965","count":3}]},{"hash":"265964743945475996","title":"Transcriptional Regulation and Chromatin Silencing","description":"Most of the top GO terms describe transcriptional processes (DNA-templated transcription, RNA Pol II elongation, transcription initiation complex assembly regulation) and chromatin state (silent mating-type cassette heterochromatin formation). A subset mentions SREBP signaling, linking transcriptional control to lipid-regulatory pathways. A couple of terms refer to ER-Golgi transport, suggesting some proteins may have additional roles, but the dominant theme across the cluster is transcriptional regulation and chromatin remodeling.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0032933","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0006888","count":3}]},{"hash":"1021711948486272111","title":"GPCR Signaling Across Sensory and Developmental Processes","description":"This cluster\u2019s top GO terms cluster around G protein-coupled receptor (GPCR) signaling and its downstream effects: adrenergic receptor signaling with adenylate cyclase activation, cAMP pathways, and phototransduction (rhodopsin-type GPCR signaling). Additional terms touch on sensory perception (pain), heart development, and cell cycle/division, which are all processes commonly modulated by GPCR signaling and related GTPase and PI biosynthesis regulation. The convergence on GPCR-mediated signaling across sensory, developmental, and metabolic contexts makes this labeling representative of the cluster\u2019s function.","confidence":"High","size":26,"edges":137,"triangles":406,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0043547","count":8},{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":7}]},{"hash":"135301918699839931","title":"Neurodevelopment and vascular formation","description":"The terms tilt toward neural/sensory development (memory, response to amphetamine, axonogenesis, otic vesicle formation) with involvement in vascular remodeling (endothelial migration, regulation of angiogenesis). Some other terms like pigmentation and bone development reflect broader developmental programs, but the central theme is neurodevelopment paired with vascular formation. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007613","count":7},{"id":"GO:0001975","count":6},{"id":"GO:0043473","count":6},{"id":"GO:0060348","count":6},{"id":"GO:0016525","count":6}]},{"hash":"987543394255930796","title":"Neural development and transcriptional regulation","description":"The cluster is enriched for terms prioritizing transcription elongation by RNA polymerase II (and its positive regulation), along with nervous system development and sensory perception of sound, pointing to proteins involved in neural development through transcriptional control. Some terms relate to histone modification and DNA repair regulation, which may reflect broader chromatin-associated functions or historical annotations. Overall, a coherent theme centers on neural development governed by transcriptional regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0006368","count":3},{"id":"GO:0032968","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0006355","count":3}]},{"hash":"343192994947876004","title":"Neural development and axon guidance","description":"Proteins in this cluster are enriched for hedgehog (Smoothened) signaling, Roundabout (ROBO) signaling, and nervous system development, with brain and kidney development terms and synaptic vesicle exocytosis regulation also present. The dominant themes center on neural patterning, axon guidance, and synaptic machinery, suggesting a cohesive neural development and connectivity theme, despite some broader developmental terms.","confidence":"High","size":26,"edges":88,"triangles":83,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007224","count":7},{"id":"GO:0035385","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0031384","count":7},{"id":"GO:0001822","count":7}]},{"hash":"527155233211655464","title":"Cerebellar development and neural signaling","description":"The strongest GO terms point to cerebellar cortex formation, Bergmann glial differentiation, and axon regeneration, indicating a cluster enriched for cerebellar development and neuron-glia interactions. Additional terms like visual perception and insulin/T cell signaling suggest broader neural and developmental signaling roles, but the core theme appears to be cerebellar structure formation and related neural processes.","confidence":"High","size":26,"edges":142,"triangles":341,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021697","count":16},{"id":"GO:0048679","count":16},{"id":"GO:0060020","count":16},{"id":"GO:0050852","count":16},{"id":"GO:2001275","count":16}]},{"hash":"1924907309375271035","title":"Neural and Pancreatic Development","description":"The top GO terms point to neural lineage specification across spinal cord and brain (motor neuron, oligodendrocyte, GABAergic interneuron differentiation; subpallium neuron fate commitment) and endocrine pancreas development (pancreatic A cell fate, endocrine pancreas development), with related transcriptional regulation and circadian controls. This suggests a coherent theme of developmental programs governing neural and pancreatic endocrine cell fates.","confidence":"High","size":26,"edges":318,"triangles":2442,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":23},{"id":"GO:0031018","count":19},{"id":"GO:0060163","count":19},{"id":"GO:0060435","count":19},{"id":"GO:0021520","count":19}]},{"hash":"2104486815918695509","title":"Glutamatergic Synapse Formation and Signaling","description":"The cluster\u2019s GO terms cluster around neuronal synapses and excitatory neurotransmission (dendrite development, glutamate secretion, receptor localization to synapse, excitatory postsynaptic potential regulation, and membrane potential regulation), indicating a coherent theme of glutamatergic synapse formation and signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016358","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0097120","count":2},{"id":"GO:2000463","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1698596554596289781","title":"Vertebrate Embryogenesis and Organ Morphogenesis","description":"The top GO terms indicate broad embryonic development and tissue morphogenesis across multiple organs (lymph node development, mesendoderm development, chorio-allantoic fusion, eyelid development, hindlimb morphogenesis, cranial skeleton morphogenesis) along with transcription regulation processes, suggesting a cohesive theme of vertebrate embryogenesis and organ formation. While some terms relate to immune system development, they can be seen as part of lymphoid organ formation during development, reinforcing the developmental focus of the cluster.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048535","count":2},{"id":"GO:0048382","count":2},{"id":"GO:0060710","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0000122","count":2}]},{"hash":"2036868106717570622","title":"Mitotic chromosome condensation and centromere assembly","description":"This cluster is dominated by mitosis- and chromatin-related terms: mitotic cell cycle, mitotic chromosome condensation, and CENP-A containing chromatin assembly, indicating a focus on centromere function and chromosome segregation. Other represented processes like ribosome biogenesis and transcription suggest baseline cellular maintenance, with ER-to-Golgi transport and ubiquitin-dependent ERAD as minor associations.","confidence":"High","size":26,"edges":18,"triangles":4,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1136849254589887445","title":"Angiogenesis and organ morphogenesis signaling","description":"This cluster centers on angiogenesis and organ development (including heart and kidney morphogenesis) with supporting roles in signaling pathways (NF-kappaB), and secretory/exocytotic processes, suggesting a cohesive module coordinating vascular development and organ formation. Anomalous terms like karyogamy may reflect annotation noise, but the dominant theme is developmental signaling across cardiovascular and renal contexts.","confidence":"Medium","size":26,"edges":35,"triangles":22,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043123","count":5},{"id":"GO:0000742","count":4},{"id":"GO:0060315","count":4},{"id":"GO:0055010","count":4},{"id":"GO:0007205","count":4}]},{"hash":"2059056654610036678","title":"Neural and sensory organ development","description":"The top GO terms center on brain and sensory organ development (brain development, inner ear development), neuronal adhesion, and related locomotion, suggesting a group function in neural/sensory system formation. Some terms point to unrelated processes (lipopolysaccharide response, antibiotic biosynthesis) or obsolescence, indicating annotation noise; nonetheless the dominant theme supports neural and sensory organ development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0021983","count":6},{"id":"GO:0007158","count":5},{"id":"GO:0007626","count":4},{"id":"GO:0007420","count":4}]},{"hash":"673734258278404159","title":"Proteasome-ubiquitin turnover and cell cycle regulation","description":"The cluster is dominated by proteasome assembly and ubiquitin-dependent protein degradation, with additional signals for mitotic cell cycle and ribosomal export, suggesting a theme of protein quality control linked to cell division. Other GO terms indicate transcription regulation and GTPase activity, which may reflect coordinated control of gene expression and signaling during proliferation. Overall, these proteins appear to function in proteostasis in the context of cell cycle progression, with some auxiliary roles in translation/export and regulation.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043248","count":5},{"id":"GO:0006511","count":5},{"id":"GO:0035914","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0051301","count":4}]},{"hash":"386118758880293548","title":"Axon Guidance and Neuronal Migration","description":"The cluster is dominated by terms related to neural development, including axon guidance (motor neuron and peripheral nervous system neuron axonogenesis), axon extension, and neuron migration (lateral motor column), as well as specialized axonal domain localization (juxtaparanode) and paranodal junction assembly, indicating a cohesive function in establishing neural connections. Some peripheral terms appear but do not override the central neural development theme.","confidence":"High","size":26,"edges":64,"triangles":28,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0071205","count":8},{"id":"GO:0048846","count":8},{"id":"GO:0030913","count":8},{"id":"GO:0014909","count":8}]},{"hash":"1096859300856804750","title":"DNA Repair and Oxidative Stress Response","description":"Most of the top GO terms point to DNA maintenance and cellular stress handling: base-excision repair and DNA recombination indicate DNA repair processes, while cellular redox homeostasis and responses to hydrogen peroxide and xenobiotic stimuli reflect oxidative and chemical stress responses. The enrichment in cell-cycle regulation (positive regulation of G1/S transition) fits with DNA damage surveillance that couples repair with cell-cycle progression. A few terms involve signaling pathways (cAMP response, phosphatidylinositol dephosphorylation) that modulate stress signaling and cell fate decisions, and a distant hint at renal water transport suggests broader signaling crosstalk. Overall, the cluster seems to group proteins involved in genome maintenance and stress-response signaling.","confidence":"High","size":26,"edges":74,"triangles":44,"max_degree":15,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":7},{"id":"GO:0007568","count":6},{"id":"GO:0006310","count":6},{"id":"GO:0042493","count":5},{"id":"GO:1900087","count":4}]},{"hash":"1503995267073183602","title":"Rac Signaling in Dendritic Spine Development","description":"This cluster centers on Rac-driven cytoskeletal remodeling and membrane dynamics that underpin dendritic spine morphogenesis and hippocampal development. Key terms point to Rac signaling, lamellipodium/ruffle assembly, and positive regulation of dendritic spine development, suggesting a shared role in shaping synaptic structures and neuronal connectivity, with membrane lipid homeostasis supporting these processes.","confidence":"High","size":26,"edges":20,"triangles":9,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":6},{"id":"GO:0010628","count":6},{"id":"GO:0010592","count":5},{"id":"GO:0016601","count":5},{"id":"GO:0061001","count":5}]},{"hash":"1019759628609881787","title":"Cell cycle and proteostasis","description":"The top GO terms cluster around cell division, cell cycle, and ribosome biogenesis, with supporting ubiquitin-mediated proteostasis (ERAD, autophagy) and protein modification, suggesting a coordinated role in cell growth and division. Some immune-related terms appear, but the core signal is growth/division and protein homeostasis.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0000747","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0006313","count":4}]},{"hash":"1742129942825112428","title":"Nephrogenesis and Podocyte Development","description":"The dominant terms reference metanephric mesenchyme migration and podocyte development, indicating kidney development (nephrogenesis). Endodermal differentiation and aldosterone-related regulation broaden the developmental and hormonal context, while immune signals appear as supporting context. Overall, the strongest theme is kidney development and nephron formation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:2000860","count":3},{"id":"GO:0032757","count":3},{"id":"GO:0034383","count":3},{"id":"GO:2000590","count":3},{"id":"GO:0070994","count":3}]},{"hash":"1785651783545891466","title":"Neural development and synapse assembly","description":"This cluster is strongly enriched for neural-related processes, including retina development, regulation of nervous system-driven respiration, and explicit synaptic organization terms (inhibitory synapse assembly, postsynaptic membrane assembly). While there are some broader development and metabolic terms, the predominant signals point to neuronal development and synaptic structure as the core theme.","confidence":"High","size":26,"edges":315,"triangles":2375,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":16},{"id":"GO:0002087","count":16},{"id":"GO:0002076","count":16},{"id":"GO:0006366","count":13},{"id":"GO:1904862","count":12}]},{"hash":"872923995951797298","title":"Vesicle trafficking and protein sorting","description":"This cluster is enriched for GO terms related to vesicle transport between the ER and Golgi, endocytosis, and vacuolar targeting (including the Cvt pathway), indicating a core role in intracellular transport and protein sorting. A few immune/metabolic terms appear but are not the primary signal. Confidence: High","confidence":"","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0006623","count":3},{"id":"GO:0006958","count":3}]},{"hash":"726929383955902537","title":"Neural development and myelination","description":"This cluster is dominated by CNS-development terms such as synapse assembly, myelination, corpus callosum development, axonal fasciculation, and cell adhesion, with supporting signals from receptor tyrosine kinase pathways and extracellular matrix organization. While a few terms are generic developmental processes, the overall pattern strongly points to neural development and myelinating glial function.","confidence":"High","size":26,"edges":9,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0042552","count":6},{"id":"GO:0035987","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0007169","count":5}]},{"hash":"1187446522475717619","title":"Endomembrane trafficking and ER\u2013Golgi organization","description":"Many terms converge on the endomembrane system: COPI vesicle coating, protein localization to the ER tubular network, endomembrane system organization, and regulation of vesicle exocytosis, plus plasma membrane repair. While some terms touch on broader signaling regulation (NF-kappaB, ERK, VEGF, IL-8), the dominant theme is membrane trafficking and ER\u2013Golgi maintenance. So the name reflects a module of proteins involved in endomembrane trafficking and ER-Golgi organization.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0032757","count":2},{"id":"GO:0030948","count":2},{"id":"GO:0001778","count":2}]},{"hash":"628052577955115618","title":"Leukocyte Activation and Recruitment","description":"The dominant GO terms point to immune cell activation and trafficking, including basophil activation, leukocyte tethering/rolling, phagocytosis recognition, platelet activation, and arachidonate secretion related to inflammatory signaling. While developmental terms like cartilage condensation and metanephric morphogenesis appear, the strongest pattern is immune-related processes involving leukocyte activation and recruitment, suggesting this cluster centers on inflammation and immune cell interactions.","confidence":"Medium","size":26,"edges":96,"triangles":181,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001502","count":9},{"id":"GO:0006910","count":9},{"id":"GO:0010572","count":9},{"id":"GO:0045575","count":9},{"id":"GO:0050901","count":9}]},{"hash":"595380724540575663","title":"Neural guidance and embryonic epithelial polarity","description":"The cluster combines neuronal guidance and migration signals (dopaminergic/serotonergic axon guidance, neuron remodeling, neuron migration) with epithelial planar polarity and organogenesis cues (planar/dichotomous subdivision in lung branching morphogenesis, maintenance of organ identity, cell adhesion), implying a developmental program where polarity cues intersect neural pathfinding.","confidence":"Medium","size":26,"edges":265,"triangles":1443,"max_degree":25,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060489","count":5},{"id":"GO:0016322","count":5},{"id":"GO:0042249","count":5},{"id":"GO:0036514","count":5},{"id":"GO:0007156","count":5}]},{"hash":"1349215584800454926","title":"Coagulation and Angiogenesis","description":"This cluster centers on blood vessel biology, with core terms for coagulation, fibrinolysis, plasminogen activation, platelet activation, and angiogenesis, suggesting a vascular remodeling/hemostasis theme, while metabolic and regenerative terms may reflect broader tissue responses.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0042730","count":6},{"id":"GO:0031639","count":6},{"id":"GO:0070328","count":5},{"id":"GO:0044320","count":5}]},{"hash":"987776756672939198","title":"Female reproductive development and prostaglandin/lipid metabolism","description":"This cluster's frequent terms point to development of female reproductive tissues (uterus and gonad) alongside lipid mediator pathways (prostaglandin biosynthesis; triglyceride metabolism). While terms like xenobiotic catabolic processes and cell-cycle regulation appear, the strongest common thread is reproductive tissue development linked with prostaglandin- and lipid-related signaling/metabolism, suggesting a module of proteins involved in female reproductive development and lipid signaling.","confidence":"Medium","size":26,"edges":138,"triangles":335,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":19},{"id":"GO:0060065","count":19},{"id":"GO:0006641","count":18},{"id":"GO:0008585","count":18},{"id":"GO:0048565","count":18}]},{"hash":"2030383656141615520","title":"Platelet Activation and Coagulation with Angiogenesis","description":"The top terms cluster around platelet activation, regulation of platelet aggregation, fibrinolysis/plasminogen activation, complement activation, and cell-matrix adhesion, all components of thrombosis and vascular remodeling. The presence of SMAD signaling and transcriptional regulation further supports a vascular/angiogenic context, tying coagulation to endothelial and matrix interactions. Therefore, this label captures the core theme of platelet/coagulation processes with angiogenesis.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0030168","count":7},{"id":"GO:0045766","count":6},{"id":"GO:0033689","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0042730","count":6}]},{"hash":"757582710186006912","title":"Innate Antiviral Immunity","description":"This cluster centers on innate immune defense, especially antiviral responses, dsRNA sensing, interferon-beta production, and NF-kappaB regulation, with links to xenophagy and broader pathogen defense (bacteria and virus signals).","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0043330","count":2},{"id":"GO:1904417","count":2}]},{"hash":"2028214218688495983","title":"DNA Transposition and Proviral Latency","description":"These proteins are enriched for DNA transposition and DNA integration, and for establishment of integrated proviral latency and defense response to virus, indicating a theme around mobile genetic elements and viral genome integration. Some cell cycle and hormone biosynthesis terms appear but the dominant signal favors transposon/provirus-related functions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0006313","count":6},{"id":"GO:0015074","count":6},{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0046718","count":4}]},{"hash":"1031135316581231162","title":"NF-\u03baB\u2013driven antiviral innate immunity","description":"Cluster is defined by strong enrichment for innate immune and antiviral functions, including positive regulation of canonical NF-kappaB signaling, defense response to virus, innate immune response, and autophagy. While a few terms relate to unrelated processes (e.g., plant brassinosteroid signaling, placental morphogenesis), the dominant theme centers on antiviral innate immunity and NF-\u03baB\u2013mediated signaling, with autophagy as a key antiviral mechanism.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043123","count":16},{"id":"GO:0051092","count":15},{"id":"GO:0051607","count":15},{"id":"GO:0045087","count":15},{"id":"GO:0006914","count":12}]},{"hash":"777499262711709274","title":"Innate immune response and autophagy","description":"The cluster is enriched for innate immune response and autophagy-related GO terms, including negative regulation of viral material transport, host suppression of viral release, and ubiquitination processes (notably K63-linked), plus regulation of NF-kappaB signaling. Together these suggest a coordinated host defense network involving immune signaling, ubiquitin-mediated regulation, and autophagic pathways in antiviral defense.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0006914","count":10},{"id":"GO:1901253","count":10},{"id":"GO:0031664","count":10}]},{"hash":"861113391943823597","title":"Innate Immunity and NF-kappaB Signaling","description":"This cluster is tied together by strong enrichment for innate immune response and antiviral defense, highlighted by terms like innate immune response, defense response to virus, and (positive regulation of) NF-kappaB signaling. Autophagy and ubiquitin-related regulation further align with antiviral defense and signaling turnover. Some other terms (microtubule localization, placental morphogenesis, brassinosteroid signaling) appear less directly related and may reflect broader functional contexts or annotation noise, but the dominant theme remains innate immunity and NF-kappaB\u2013driven signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":15},{"id":"GO:0051092","count":14},{"id":"GO:0051607","count":12},{"id":"GO:0043123","count":12},{"id":"GO:0035372","count":11}]},{"hash":"3497988090238674","title":"NF-kappaB-driven antiviral innate immunity","description":"The top GO terms-center on canonical NF-kappaB signaling, innate immune response, defense against virus, and MHC class I biosynthesis-support a coherent module of NF-kB\u2013mediated antiviral defense and antigen presentation, with autophagy linking viral clearance and immune signaling. While a few terms are less directly related, the dominant pattern points to an innate immune/NF-kB function cluster.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043123","count":14},{"id":"GO:0051092","count":12},{"id":"GO:0051607","count":12},{"id":"GO:0045087","count":12},{"id":"GO:0045345","count":11}]},{"hash":"779516680157131296","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":11},{"id":"GO:2000637","count":11},{"id":"GO:0061158","count":11},{"id":"GO:1902187","count":11},{"id":"GO:0043569","count":8}]},{"hash":"1594895604441870830","title":"Unknown","description":"The top GO terms span female pregnancy, xenobiotic response, trachea formation, cardiac muscle regulation, and B cell signaling, indicating diverse developmental and immune processes without a single unifying function. Because there's no cohesive theme tying the 26 proteins together, a generic Unknown label with None confidence is most appropriate.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007565","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0060440","count":2},{"id":"GO:0043433","count":2}]},{"hash":"744356548446896424","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":18},{"id":"GO:0007014","count":18},{"id":"GO:2000637","count":18},{"id":"GO:0061158","count":18},{"id":"GO:0018032","count":14}]},{"hash":"2009333393875242600","title":"Innate Immune Activation and NF-kB Regulation","description":"The GO terms cluster around innate immune sensing and inflammatory signaling, including detection of LPS, macrophage activation, dendritic cell cytokine production, defense against bacteria, and regulation of NF-kB signaling, plus ubiquitin-proteasome\u2013dependent protein turnover. Together these indicate a cohesive theme of macrophage/dendritic cell\u2013driven innate immune responses with NF-kB\u2013mediated cytokine production, despite a couple of outliers related to DNA transposition. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0043124","count":3}]},{"hash":"690031770619278654","title":"Mitochondrial respiration and metabolite transport","description":"The top GO terms converge on mitochondrial energy production (cristae formation, proton motive force-driven ATP synthesis) and related protein complex assembly, with accompanying transport roles for ammonium and carbon dioxide, suggesting a cohesive cluster centered on mitochondrial metabolism and metabolite movement, despite some outlier developmental terms.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":2},{"id":"GO:0060325","count":1},{"id":"GO:0035786","count":1},{"id":"GO:0015986","count":1},{"id":"GO:0042407","count":1}]},{"hash":"1207103816007840167","title":"Transcription Regulation and Germ Cell Development","description":"The cluster shows enrichment for transcription-related processes (DNA-templated transcription; negative regulation of transcription by RNA polymerase II), along with DNA replication and rRNA maturation, pointing to central nuclear gene-expression machinery. The presence of spermatogenesis and male gonad development terms suggests germ cell development contexts, while the T cell receptor V(D)J recombination term hints at immune system-related processes. Overall, the common thread appears to be nuclear gene expression and development, especially in germline contexts, with some immune-associated annotations. Confidence: Medium","confidence":"","size":25,"edges":22,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1722930022820187965","title":"Developmental signaling and tissue morphogenesis","description":"This cluster shows enrichment for developmental signaling (Wnt pathway, MAPK cascade) and morphogenesis processes, including eye photoreceptor/cone differentiation and skin morphogenesis, suggesting proteins that coordinate signaling cues to drive tissue differentiation and form. Some chromatin-related terms are present but less central to the main theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048681","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0016055","count":1},{"id":"GO:0000196","count":1}]},{"hash":"1608276200311961497","title":"GPCR-Mediated Signaling and Visual Perception","description":"The cluster centers on GPCR-driven signaling with downstream cAMP and calcium regulation (adenylate cyclase activation, cAMP signaling, calcium release), and includes regulation of opsin-mediated signaling and visual perception, pointing to photoreceptor/retinal pathways. It also encompasses dopaminergic/aminergic signaling (response to amphetamine) and GTPase activity, suggesting a broader neuromodulatory GPCR network. Overall, the GO terms converge on GPCR signaling influencing neural and visual functions.","confidence":"High","size":25,"edges":76,"triangles":265,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007190","count":17},{"id":"GO:0007507","count":16},{"id":"GO:0006468","count":16},{"id":"GO:0001975","count":16},{"id":"GO:0007601","count":16}]},{"hash":"1365816346987655941","title":"GPCR-MAPK signaling in heart and inflammation","description":"These proteins cluster around GPCR signaling and downstream MAPK/ERK activation, as indicated by terms like activation of adenylate cyclase, positive regulation of ERK1/ERK2 cascade, and GPCR signaling. Additional terms point to prostaglandin- and opsin-mediated signaling and inflammatory or defense responses, alongside heart development and cell proliferation. Together, they suggest a functional module of GPCR-driven signaling with cardiovascular and inflammatory roles.","confidence":"Medium","size":25,"edges":7,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0001975","count":6},{"id":"GO:0007190","count":6},{"id":"GO:0070374","count":5},{"id":"GO:0042742","count":5}]},{"hash":"992883423568905010","title":"Cranial Skeleton Morphogenesis and Wnt Signaling","description":"The top GO terms show strong enrichment for embryonic cranial skeleton morphogenesis and positive regulation of canonical Wnt signaling, indicating proteins involved in cranial skeletogenesis and Wnt pathway regulation. Additional terms related to transcription, DNA replication, and signaling/adhesion (ephrin signaling, focal adhesion) suggest these proteins participate in broader cell signaling and adhesion dynamics accompanying morphogenesis. Overall, the cluster seems best characterized by a link between cranial skeletal development and Wnt pathway activity.","confidence":"Medium","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":12},{"id":"GO:0090263","count":11},{"id":"GO:0006260","count":11},{"id":"GO:0045944","count":10},{"id":"GO:0050852","count":9}]},{"hash":"366489095329019374","title":"Developmental morphogenesis and transcription regulation","description":"Despite the lack of edges, the dominant GO terms center on organ development and morphogenesis (eye, inner ear, pituitary, lung-related epithelial branching) and transcriptional control (RNA polymerase II activity and its negative regulation). This pattern suggests a cluster representing developmental regulation of sensory and endocrine organs, with transcriptional regulation as a core mechanism. Some outliers may reflect noise or annotation artifacts but do not undermine the main theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0021983","count":6},{"id":"GO:0042128","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0043010","count":5}]},{"hash":"1877527506684114353","title":"Hemostasis: Platelet Coagulation and Fibrinolysis","description":"This cluster is dominated by terms for blood coagulation, platelet aggregation, fibrinolysis, plasminogen activation, and regulation of platelet activity, pointing to a core hemostasis module. Additional terms on angiogenesis and IL-1\u2013related signaling hint at vascular remodeling and inflammatory context often associated with coagulation processes, supporting a cohesive label around hemostasis and platelet control.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090331","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0045766","count":4},{"id":"GO:0035641","count":4},{"id":"GO:1902042","count":4}]},{"hash":"834303061348088195","title":"Embryonic organogenesis and gene expression","description":"The cluster centers on developmental processes, with terms for in utero embryonic development, heart and pancreas morphogenesis, and neuron maturation, suggesting an emphasis on organogenesis during development. It is complemented by core gene-expression terms (DNA-templated transcription and translation), indicating these proteins are involved in regulating development via transcription and protein synthesis. A few stress/immune terms (response to lipopolysaccharide, response to cold) are present but less prominent, implying they are secondary associations. Overall, it seems to reflect developmental gene-expression programs guiding organ formation.","confidence":"Medium","size":25,"edges":18,"triangles":16,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":4},{"id":"GO:0042551","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1677528731899484982","title":"Interferon-responsive bone and neural development proteins","description":"These proteins show enrichment for interferon-\u03b1/\u03b2 response terms alongside bone mineralization/morphogenesis and neural/muscular processes (e.g., synaptic vesicle clustering, postural control). Additional terms like brown fat differentiation and insulin-related glucose transport point to metabolic signaling. Taken together, the cluster appears to group immune signaling with skeletal and neural development, justifying a label that spans these related domains.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046597","count":3},{"id":"GO:0050873","count":3},{"id":"GO:0035456","count":2},{"id":"GO:0030282","count":2},{"id":"GO:0099638","count":2}]},{"hash":"371358733313776174","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":8},{"id":"GO:0051865","count":7},{"id":"GO:0043123","count":7},{"id":"GO:0016567","count":6},{"id":"GO:0071260","count":6}]},{"hash":"1969141686781857309","title":"Metabolism, Methylation, and Cell-Cycle Regulation","description":"The cluster centers on diverse metabolic processes (biotin biosynthesis, nitrogen utilization, uracil catabolism) and xenobiotic response, with strong signals for cell-cycle progression (cell division, mitotic cell cycle). It also includes methylation-related functions (RNA guanine-N7 methylation and protein methylation) and ER-to-Golgi transport, suggesting an integrated program of metabolism, gene-expression modification, and intracellular trafficking that supports growth and stress responses.","confidence":"Medium","size":25,"edges":5,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035690","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0019740","count":3},{"id":"GO:0006212","count":3}]},{"hash":"1034575238043289458","title":"Neuronal development and synapse/axon guidance","description":"The top GO terms cluster around nervous system development, synapse assembly, axon extension, ephrin signaling, and cell-adhesion, indicating roles in neural formation and connectivity. Although ossification appears, the predominant signal is neural development and synaptic/axon guidance processes, suggesting the proteins work together in establishing neural networks and synaptic function.","confidence":"High","size":25,"edges":8,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0043931","count":6},{"id":"GO:0051291","count":5},{"id":"GO:0090051","count":4},{"id":"GO:0051965","count":4}]},{"hash":"475720172032292786","title":"Innate antiviral signaling and autophagy","description":"The terms show innate antiviral defense, NF-\u03baB/TNF signaling, antiviral ubiquitination, and autophagy, plus microtubule trafficking of viral material, pointing to a coordinated innate response to viruses.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":15},{"id":"GO:0045087","count":15},{"id":"GO:1901253","count":13},{"id":"GO:1903265","count":13},{"id":"GO:0035372","count":13}]},{"hash":"1993351974671278557","title":"Innate Immunity and NF-\u03baB Signaling with Autophagy","description":"The top terms cluster around innate immune responses (innate immune response, defense against virus) and regulation of the NF-\u03baB pathway (positive regulation of canonical NF-\u03baB signaling), alongside autophagy and ubiquitin-related processes, suggesting a cohesive group of proteins involved in antiviral immunity and NF-\u03baB\u2013mediated signaling with autophagic/ubiquitin turnover.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":10},{"id":"GO:0045087","count":9},{"id":"GO:0051607","count":8},{"id":"GO:0043123","count":8},{"id":"GO:0051865","count":8}]},{"hash":"415313847589160419","title":"Cardiac sarcomere organization and contraction","description":"Top GO terms are dominated by sarcomere organization and cardiac muscle contraction, with supporting terms about heart rate regulation and sarcomere regulation. This points to a cohesive theme of heart muscle structure and function, despite a couple of peripheral terms related to vascular development and BMP signaling. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0021942","count":2},{"id":"GO:0071773","count":2},{"id":"GO:0003065","count":2}]},{"hash":"1971331592182434589","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0051402","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0051028","count":3}]},{"hash":"1916607011509041204","title":"Vesicle Trafficking and Signaling","description":"Based on GO terms, the cluster centers on membrane trafficking and signaling processes: endosome-to-plasma membrane transport, synaptic vesicle clustering, and ether lipid metabolism, which influence membrane dynamics; plus insulin-responsive glucose import suggesting metabolic signaling. While immune (interferon) and skeletal/bone-related terms are present, the dominant theme appears to be lipid/vesicle transport and associated signaling pathways that could apply across neuromuscular and immune contexts.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046485","count":3},{"id":"GO:0035456","count":3},{"id":"GO:0030282","count":3},{"id":"GO:0099638","count":3},{"id":"GO:0044381","count":3}]},{"hash":"162224028196639053","title":"Multi-tissue development and organogenesis","description":"The top GO terms cluster around development and maturation across diverse tissues: skin, bone ossification, retina layer formation, and heart-related signaling. There's also a connection to vascular regulation, multicellular development, and tissue-specific responses, suggesting a broad developmental theme rather than a single pathway. Some terms reflect tissue stress responses, but they still align with developmental and organizational processes in organisms. Overall, this cluster seems best described as multi-tissue development and organogenesis.","confidence":"High","size":25,"edges":265,"triangles":1616,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030948","count":23},{"id":"GO:0043588","count":15},{"id":"GO:0043931","count":15},{"id":"GO:0010842","count":15},{"id":"GO:0086029","count":15}]},{"hash":"1640691075832743906","title":"Innate Immune Activation and Signaling","description":"This cluster is strongly enriched for innate immune functions: cellular response to fungal origin, phagocytosis recognition, stimulatory C-type lectin receptor signaling, leukocyte tethering or rolling, basophil activation, and NK cell chemotaxis regulation. While a few terms relate to developmental processes (cartilage condensation, metanephric/distal tubule morphogenesis, mesonephric duct development), the dominant signal is immune activation and leukocyte interactions, pointing to an innate immune signaling core within the cluster.","confidence":"High","size":25,"edges":27,"triangles":13,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":12},{"id":"GO:0001502","count":12},{"id":"GO:0010572","count":12},{"id":"GO:0002223","count":12},{"id":"GO:0006910","count":11}]},{"hash":"73304192326477682","title":"Protein quality control and trafficking","description":"This cluster centers on processes that maintain protein folding and proper localization, including unfolded protein response, ER stress management, chaperone-assisted refolding, and SRP-dependent targeting to membranes. The terms strongly point to protein homeostasis and processing, with some peripheral members (e.g., iron-sulfur cluster assembly and fungal-specific processes) that may reflect broader cellular stress contexts in these organisms. ","confidence":"Medium","size":25,"edges":183,"triangles":658,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":9},{"id":"GO:1903382","count":9},{"id":"GO:0006880","count":9},{"id":"GO:0016226","count":9},{"id":"GO:0034620","count":9}]},{"hash":"184776673446930822","title":"Neural development and cholinergic signaling","description":"The cluster is dominated by nervous system-related terms: axon guidance regulation, Schwann and retina development, radial glia\u2013neuron interactions, and G protein-coupled acetylcholine receptor signaling, along with receptor clustering and cholinergic synaptic transmission. While a couple terms touch on other organogenesis (podocytes, brown fat), the central theme is neural development and cholinergic signaling.","confidence":"High","size":25,"edges":293,"triangles":2150,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:1905815","count":3},{"id":"GO:0072249","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0032224","count":3},{"id":"GO:0014044","count":3}]},{"hash":"565047180111229966","title":"Embryonic Development and Innate Immunity Regulation","description":"The set includes terms tied to embryonic development and angiogenesis, along with complement activation (classical and alternative) and membrane attack complex regulation, suggesting innate immune signaling during development. Additional terms on necroptosis (ripoptosome assembly) and chromatin/modification (histone deubiquitination and methylation) imply epigenetic control of gene expression in these processes. Together, they point to a theme of developmental regulation intertwined with innate immune pathways rather than a single, narrow function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0006957","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0001970","count":2}]},{"hash":"1039487492635670763","title":"ECM Remodeling and EMT with Endothelial Migration","description":"This cluster is dominated by extracellular matrix organization terms (collagen and fibronectin fibril organization) and epithelial-to-mesenchymal transition, along with endothelial cell migration, pointing to ECM remodeling and EMT-driven cell movement. Additional signals like integrin signaling, endocytosis, and innate immune responses suggest coordinated cell-ECM communication and immune modulation during remodeling and angiogenesis.","confidence":"High","size":25,"edges":27,"triangles":0,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":19},{"id":"GO:0045087","count":19},{"id":"GO:1905590","count":18},{"id":"GO:0001837","count":18},{"id":"GO:0010886","count":18}]},{"hash":"888651689760120620","title":"Cell Division and Chromosome Segregation","description":"The top GO terms are dominated by mitotic and meiotic chromosome separation and general cell division, with additional signals for regulation of DNA replication and cell-cycle-related nuclear import/desumoylation. A few vesicle transport terms appear, but they don\u2019t define the cluster; the core theme is proteins involved in chromosome segregation and cell-cycle control.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051306","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0051307","count":3}]},{"hash":"190198737257162040","title":"Neural-vascular adhesion and morphogenesis","description":"This cluster centers on GO terms tied to cell-matrix adhesion and tissue morphogenesis, including calcium-independent adhesion, somitogenesis, coronary artery morphogenesis, and axon-related processes (paranodal junction assembly, juxtaparanode localization, and axon extension). While there is a visible inflammatory signal (response to lipopolysaccharide) in the mix, the strongest shared theme is adhesion and developmental morphogenesis across neural and vascular contexts, suggesting a core role in building and guiding tissues where nerves and blood vessels interact. Confidence: Medium","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0007596","count":8},{"id":"GO:0007161","count":8},{"id":"GO:0032496","count":8},{"id":"GO:0030913","count":8}]},{"hash":"687430708066642069","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":13},{"id":"GO:0045087","count":10},{"id":"GO:0035372","count":9},{"id":"GO:0006914","count":8},{"id":"GO:1903265","count":8}]},{"hash":"1662855306339552762","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":16},{"id":"GO:0007014","count":16},{"id":"GO:2000637","count":16},{"id":"GO:0061158","count":16},{"id":"GO:0051092","count":15}]},{"hash":"956043158810775409","title":"Angiogenesis and vascular morphogenesis","description":"The cluster centers on vascular development, with GO terms for endothelial migration/chemotaxis, endothelial/ cell-matrix adhesion, and coronary artery morphogenesis, plus related processes like blood coagulation and angiogenesis regulation. This cohesive set points to vessel formation and endothelial interactions as the core theme, despite some ECM/remodeling and glial terms that may reflect broader tissue remodeling contexts.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014909","count":3},{"id":"GO:0035767","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0042066","count":3},{"id":"GO:0007596","count":2}]},{"hash":"526964829667331672","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":22},{"id":"GO:0051607","count":22},{"id":"GO:0043123","count":22},{"id":"GO:0045087","count":22},{"id":"GO:1902187","count":19}]},{"hash":"2303698240393215550","title":"Cardiovascular GPCR-cAMP signaling and calcium regulation","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling, activation of adenylate cyclase, and calcium release, pointing to GPCR-cAMP pathways that control vascular tone and cardiac function. Prostaglandin response, blood pressure regulation, and vascular smooth muscle differentiation further reinforce a cardiovascular signaling theme. Inflammation and coagulation terms appear as secondary connections, while electron transport chain terms may reflect cardiac energy demands rather to core cluster function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0045777","count":21},{"id":"GO:0035025","count":20},{"id":"GO:0007190","count":19}]},{"hash":"456881388945200784","title":"Integrin signaling and cell adhesion in immunity","description":"The top GO terms center on integrin-mediated signaling and regulation of cell motility, pointing to adhesive and migratory functions. Additional terms reflect immune signaling (NF-kappaB, Notch) and interactions at cell junctions or barriers (dendritic cell regulation, septate junctions, vascular development), suggesting a broader theme of surface signaling coordinating adhesion/movement with immune and developmental processes. This combination supports a concise label focused on adhesive signaling with immune context, though the cluster spans related developmental and barrier-related roles as well.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":3},{"id":"GO:2000145","count":2},{"id":"GO:1901223","count":2},{"id":"GO:0046813","count":2},{"id":"GO:0043128","count":2}]},{"hash":"200126635396310838","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":19},{"id":"GO:0007014","count":19},{"id":"GO:0061158","count":19},{"id":"GO:0007026","count":19},{"id":"GO:0006914","count":18}]},{"hash":"2055001130464079625","title":"Neuronal signaling and behavioral regulation","description":"The cluster shows enrichment for neural signaling and behavior-related processes: sensory perception of pain, locomotory behavior, temperature stimulus response, neuropeptide signaling, calcium ion release, and regulation of monoaminergic signaling (serotonin and dopamine) and opsin signaling. Together these terms point to a cohesive network governing nociception, movement, and thermogenic/metabolic responses, rather than a single tightly connected pathway; the zero edges suggest functional similarity rather than direct interactions, though 11 proteins were re-added by ReCIPE.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0002024","count":9},{"id":"GO:0007626","count":9},{"id":"GO:0071502","count":9},{"id":"GO:0007218","count":8}]},{"hash":"1395719615649194096","title":"Developmental Morphogenesis and Patterning","description":"The GO terms cluster around embryonic development and tissue morphogenesis across multiple organ systems (mesoderm, left-right patterning, cartilage and palate, hair follicles, pancreas, placenta) and Hedgehog pathway regulation, with splicing contributing to gene expression during development \u2014 a unifying theme of developmental patterning and morphogenesis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045880","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0007498","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0031069","count":2}]},{"hash":"1020280350255402534","title":"Skeletal development and signaling","description":"The cluster is dominated by bone-related terms: skeletal system development, bone mineralization, and positive regulation of signaling pathways (Notch target transcription and Smoothened/Hedgehog signaling). While there are a few broader developmental terms (AV node development, reproductive development), the strong emphasis on bone formation and key developmental signaling pathways supports a cohesive label around skeletal development and its signaling regulators.","confidence":"High","size":24,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":4},{"id":"GO:0003162","count":3},{"id":"GO:0007221","count":3},{"id":"GO:0097211","count":3},{"id":"GO:2000354","count":3}]},{"hash":"1312466227870328275","title":"Developmental regulation and tissue organization","description":"The terms point to broad roles in gene expression control (DNA-templated transcription, mRNA processing) and cell proliferation (mitotic cell cycle, telomere maintenance), coupled with developmental and tissue-context functions (forebrain development, visual perception, fat cell differentiation, cell-matrix adhesion, septate junction assembly, response to muscle stretch). This suggests a cluster involved in development and the structural organization of tissues rather than a single, cohesive pathway. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0030900","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0090528","count":2}]},{"hash":"576796845352246319","title":"Neural development and forebrain formation","description":"The cluster shows strong representation of neural development terms (neural tube closure, nervous system development, forebrain development), indicating proteins likely involved in brain formation. Other terms (ribosomal subunit export, response to nitric oxide, lipid metabolism) are present but less central, so the dominant theme is neural development with some peripheral functions.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0010667","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0000056","count":2}]},{"hash":"188760140671907142","title":"Auditory-vestibular neural signaling and sensory processing","description":"This cluster centers on neural signaling and sensory pathways, with strong representation of auditory/vestibular components (mechanical stimulus detection for hearing, vestibulocochlear nerve development, lateral geniculate nucleus development) alongside broad neurotransmitter-related processes (serotonin, dopamine pathways, cholinergic transmission, membrane depolarization) and motor/sensory integration (locomotory behavior, heart rate regulation). Together these terms suggest a cohesive theme of neurons mediating sensory perception and downstream neural signaling.","confidence":"High","size":24,"edges":27,"triangles":16,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":12},{"id":"GO:0007210","count":10},{"id":"GO:0071805","count":10},{"id":"GO:0033603","count":10},{"id":"GO:0001988","count":10}]},{"hash":"1468010852294109390","title":"Unknown","description":"Top terms span nuclear transport, DNA replication regulation, hormone metabolism, ion transport, cytoskeletal shaping, signaling, and endothelial proliferation; the functions are too diverse to define a single cohesive theme for this cluster.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051028","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0035725","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0008360","count":2}]},{"hash":"553648463135824629","title":"Insect pheromone lipid biosynthesis and secretion","description":"The cluster is enriched for multiple fatty acid elongation and biosynthetic terms (long-chain, very long-chain, monounsaturated, unsaturated, saturated) alongside pheromone metabolic process and courtship behavior, pointing to production of lipid-based pheromones and mating signals. The presence of transport terms (post-Golgi vesicle-mediated transport, endosome-to-vacuole pathway) supports secretory trafficking for pheromone release. A single hedgehog/Smoothened signaling term is less central but may reflect lipid-related signaling. Overall, a cohesive theme of pheromone lipid biosynthesis and secretion is evident.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045880","count":2},{"id":"GO:0007619","count":1},{"id":"GO:0034625","count":1},{"id":"GO:0042810","count":1},{"id":"GO:0006892","count":1}]},{"hash":"954898533630150467","title":"Ubiquitin-mediated innate antiviral defense","description":"This cluster centers on innate antiviral defense and ubiquitin-dependent processes, with repeated signals for defense response to virus, innate immune response, and protein ubiquitination (including K6-linked ubiquitination) and autophagy, plus ERAD-related terms. The co-occurrence suggests proteins that act in antiviral defense through ubiquitin signaling and protein quality control.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0048535","count":1},{"id":"GO:0006914","count":1}]},{"hash":"1435575419030807381","title":"Neural development and synapse formation","description":"The top GO terms cluster around neural and synaptic processes, including brain and nervous system development, inner ear development, locomotory behavior, and especially positive regulation of synapse assembly and dendritic spine morphogenesis. Although a few terms (cartilage development, blood coagulation, apoptosis, NF-kappaB signaling) are broader or ancillary, the dominant theme is neural development and synaptic/morphogenetic remodeling. Confidence: High","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0007420","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0007399","count":4}]},{"hash":"1875290496154365720","title":"Reproductive development and morphogenesis","description":"The top GO terms cluster around fertilization-related processes (prevention of polyspermy; regulation of sperm binding to the zona pellucida) and developmental/morphogenetic pathways (embryonic fin morphogenesis, maternal axis specification, hepatocyte growth factor signaling). There are also related roles in tissue remodeling and growth regulation (proteolysis, cuticle molting). Together, these point to a group of proteins involved in early development and reproductive signaling, with some lineage-specific morphogenesis elements. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060468","count":3},{"id":"GO:0048012","count":3},{"id":"GO:0048632","count":3},{"id":"GO:0018996","count":3},{"id":"GO:2000360","count":3}]},{"hash":"1230121386060178103","title":"Rho GTPase and Actin Cytoskeleton Regulators","description":"This cluster is dominated by GO terms for regulation of Rho signaling and actin cytoskeleton organization, centered on small GTPase pathways. The presence of neural-related terms (sensory perception of sound, long-term synaptic depression, social behavior) suggests these proteins are involved in neuronal signaling and synaptic plasticity, in addition to cytoskeletal remodeling. The combination points to a cohesive function in GTPase-driven cytoskeletal dynamics within neurons, with supporting growth signaling (IGF receptor pathway) and GTPase activity regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0030036","count":5},{"id":"GO:0007264","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0060292","count":4}]},{"hash":"96267468533603313","title":"Immune signaling and phagocytosis","description":"Top GO terms indicate activation of signaling pathways (ERK cascade, integrin signaling) and immune processes (innate immune response, T cell receptor signaling, beta selection) as well as engulfment of apoptotic cells. Together these point to a module centered on immune cell signaling and clearance of dying cells, with other terms like skeletal development appearing less central. Confidence in this labeling is high.","confidence":"High","size":24,"edges":4,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0007229","count":4},{"id":"GO:0043652","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0045087","count":4}]},{"hash":"412310561191022419","title":"Proteoglycan Biosynthesis in Craniofacial Development","description":"The strongest signals are keratan sulfate proteoglycan biosynthetic process and embryonic neurocranium morphogenesis, pointing to extracellular matrix proteoglycans (GAGs) contributing to craniofacial development. Other metabolic terms appear as less coherent noise, but the core theme supports a proteoglycan- and craniofacial-development connection.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048702","count":11},{"id":"GO:0002002","count":11},{"id":"GO:0030205","count":11},{"id":"GO:0018146","count":11},{"id":"GO:0030206","count":11}]},{"hash":"265199680360679460","title":"RNA Processing and Transcription Regulation","description":"The terms cluster around RNA metabolism and gene expression control, including DNA replication, mRNA processing/splicing, ncRNA-mediated silencing, chromatin silencing, transcriptional regulation, and translation initiation, with a peripheral defense-response term. This supports a cohesive RNA-centric regulatory module.","confidence":"Medium","size":24,"edges":5,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0030466","count":4}]},{"hash":"1871429929701704762","title":"Developmental cell adhesion and morphogenesis (muscle, lung)","description":"The cluster shows strong hints of development-related processes, with terms like receptor clustering, heterophilic cell-cell adhesion, and recognition of apoptotic cells, plus muscle-specific and lung morphogenesis roles (skeletal muscle satellite cell activation/differentiation; lung morphogenesis and branching-related terms; planar orientation). While a few terms are broader, the dominant signal ties cell adhesion to morphogenesis across muscle and lung contexts, supporting a cohesive theme of developmental cell interactions shaping tissue formation.","confidence":"High","size":24,"edges":31,"triangles":7,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0043113","count":7},{"id":"GO:0043654","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0060490","count":5}]},{"hash":"687894819456107011","title":"Axon Guidance and Paranodal Assembly","description":"This cluster is dominated by terms related to axon guidance, paranodal junction assembly, and localization of proteins to juxtapos/ paranodal regions, pointing to neuronal development and axon organization. Additional terms about cell adhesion, integrin signaling, and cardiac/muscle morphogenesis likely reflect shared adhesion and migratory mechanisms in developing tissues, but the core theme appears to be neural connectivity and axon maturation.","confidence":"Medium","size":24,"edges":76,"triangles":36,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0071205","count":9},{"id":"GO:0048846","count":9},{"id":"GO:0030913","count":9},{"id":"GO:0014909","count":9}]},{"hash":"924051091034744660","title":"Metabolism and Neural Differentiation","description":"The cluster shows strong representation of metabolic processes (retinol metabolism, fructose biosynthesis, ethanol catabolic/oxidation) alongside neural differentiation terms (visceral motor neuron differentiation, midbrain dopaminergic neuron differentiation) and a cardiac muscle development term, suggesting a mix of metabolic regulation and neuronal development signals. While there is some noise from cytoskeletal and cell wall processes, the recurrent neural differentiation terms plus metabolism dominate, justifying a combined label centered on metabolism and neural development.","confidence":"Medium","size":24,"edges":206,"triangles":1174,"max_degree":22,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0042572","count":11},{"id":"GO:0046370","count":9},{"id":"GO:0006068","count":7},{"id":"GO:0006069","count":7}]},{"hash":"985690653854671465","title":"Neural connectivity and vascular development cues","description":"The cluster is dominated by neuronal development terms\u2014synapse assembly, axon extension/guidance, NMDA receptor clustering\u2014and cell adhesion/signaling (integrin signaling, cell-matrix adhesion), with vascular-related processes (PDGF receptor signaling, coronary artery morphogenesis, platelet aggregation). This suggests proteins coordinating neural connectivity with extracellular matrix and vascular cues.","confidence":"Medium","size":24,"edges":17,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007416","count":9},{"id":"GO:0060982","count":9},{"id":"GO:0048846","count":9},{"id":"GO:0048842","count":9},{"id":"GO:0010641","count":8}]},{"hash":"586828868959118976","title":"TLR/NF-kB Mediated Inflammatory Signaling","description":"The cluster is dominated by innate immune and inflammatory pathways: cellular response to lipopolysaccharide, TLR9 signaling, NF-kappaB regulation, IL-1\u2013mediated signaling, chemokine production, and neutrophil extravasation, with ERK cascade involvement, pointing to a coherent innate immune activation theme. An outlier term about synapse assembly is minor noise relative to the core inflammatory signals.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":7},{"id":"GO:0071222","count":7},{"id":"GO:0051965","count":6},{"id":"GO:0090197","count":6},{"id":"GO:2000391","count":6}]},{"hash":"578393188145524801","title":"Kidney and cartilage development with immune signaling","description":"The top GO terms indicate kidney morphogenesis (metanephric ascending thin limb development, distal tubule morphogenesis, mesonephric duct development) and cartilage condensation, pointing to organogenesis, while concurrent immune-related terms (leukocyte tethering/rolling, basophil activation, phagocytosis recognition, NK cell chemotaxis regulation) suggest immune modulation during development. This pattern supports a developmental program governing kidney and skeletal formation with integrated immune signaling.","confidence":"Medium","size":24,"edges":17,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":11},{"id":"GO:0071226","count":11},{"id":"GO:0072218","count":11},{"id":"GO:0006910","count":10},{"id":"GO:0010572","count":10}]},{"hash":"1388687793636526819","title":"Detoxification and Toxic-Substance Response","description":"The top GO terms are dominated by cellular oxidant detoxification and response to toxic substances, suggesting the cluster mainly comprises proteins involved in detoxification and oxidative stress responses. While there are other terms (oxygen transport, blood coagulation, muscle fiber contraction, adipose differentiation) present, they appear as more indirect annotations, making detox/oxidative stress the strongest unifying theme for this cluster.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":8},{"id":"GO:0009636","count":7},{"id":"GO:0009399","count":5},{"id":"GO:2000490","count":4},{"id":"GO:0007596","count":4}]},{"hash":"185647045787878982","title":"Bacterial steroid and lipid biosynthesis","description":"The cluster is enriched for steroid-related metabolism (androgen and glucocorticoid pathways) and lipid biosynthesis (methyl-branched fatty acids, poly-hydroxybutyrate) plus related catabolic processes, with additional microbial biosynthetic activity (antibiotics) and sporulation. This suggests a cohesive theme around bacterial steroid and lipid metabolic pathways and related biosynthesis, justifying the label. ","confidence":"Medium","size":24,"edges":75,"triangles":123,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":17},{"id":"GO:0042208","count":16},{"id":"GO:0017000","count":16},{"id":"GO:0008207","count":15},{"id":"GO:0006706","count":15}]},{"hash":"1225435189194927978","title":"Innate Antiviral Defense and Membrane Repair","description":"The cluster is dominated by GO terms related to innate immune response and defense against viruses, including host-mediated suppression of viral release and plasma membrane repair. Additional terms about NF-kappaB signaling and actin-related processes suggest coordinated signaling and cytoskeletal responses during antiviral defense, with some metabolic term noise. Overall, these terms point to a cohesive antiviral innate immunity theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045725","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0051260","count":6},{"id":"GO:0010804","count":6},{"id":"GO:0051092","count":5}]},{"hash":"2138658729005634386","title":"TLR/NF-\u03baB-driven innate immune activation","description":"The proteins cluster around innate immune sensing and NF-kappaB signaling, with terms for TLR signaling, LPS detection, antiviral defense, and production of inflammatory chemokines (e.g., CXCL1, CXCL5) and IL-23. The inclusion of platelet activation and mechanical-stimulus responses suggests integration with inflammatory coagulation and mechanotransduction, supporting a cohesive role in early immune/inflammatory signaling.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032747","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0051607","count":5},{"id":"GO:2000340","count":5},{"id":"GO:0071260","count":5}]},{"hash":"868075492098889491","title":"Innate antiviral inflammation via NF-kappaB signaling","description":"This cluster is dominated by GO terms for innate immune response, activation of canonical NF-kappaB signaling, and defense against viruses (including TNF and IL-17 pathways, and suppression of viral release). While a few terms touch on miRNA metabolism and stem cell proliferation, the predominant theme is innate immune signaling and antiviral defense mediated by NF-kappaB/TNF pathways. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":15},{"id":"GO:0051092","count":14},{"id":"GO:0043123","count":12},{"id":"GO:0051607","count":11},{"id":"GO:0072089","count":9}]},{"hash":"1410039416574398330","title":"Innate immunity, antiviral defense, and autophagy","description":"The top GO terms cluster around innate immune response, NF-kappaB regulation, autophagy, and antiviral processes, indicating coordinated immune signaling and autophagic control of viral components. Additional terms on ubiquitin-dependent proteolysis and epigenetic regulation fit into immune signaling and gene-expression modulation during defense. Some plant-specific or obsolete terms appear, but the dominant theme is innate immune defense linked to autophagy.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":13},{"id":"GO:0051092","count":12},{"id":"GO:0006914","count":11},{"id":"GO:1900458","count":11},{"id":"GO:2000059","count":11}]},{"hash":"791757838300783101","title":"Neuronal signaling and hypoxia response proteins","description":"The terms point to neural function (memory; neurotransmitter secretion) and signaling regulation (kinase/GTPase/autophosphorylation) with a hypoxia stress component, plus mRNA transport that supports local translation in neurons. A few terms about cell proliferation/mitosis are less consistent, so the theme is tentative.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":5},{"id":"GO:0051028","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0000278","count":4}]},{"hash":"540244888541477975","title":"Telomere maintenance and telomerase regulation","description":"This cluster is dominated by GO terms related to telomere maintenance, telomerase regulation, telomere capping, and localization to telomeric regions, with additional hints from ADP-ribosylation processes and mitotic spindle/cohesion terms. The shared focus on preserving telomere integrity and telomerase activity suggests a coherent function center around telomere maintenance rather than unrelated processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070212","count":11},{"id":"GO:0051225","count":11},{"id":"GO:1904357","count":11},{"id":"GO:0016055","count":11},{"id":"GO:0070198","count":11}]},{"hash":"1501225109823239354","title":"Inflammation-driven calcium signaling and coagulation","description":"The top GO terms cluster around inflammatory and vascular processes: regulation of IL-1\u03b2 production, Ca2+ release into the cytosol, prostaglandin response, and blood coagulation, with additional signals related to vascular smooth muscle differentiation. Some terms like grooming or phototransduction seem incidental and do not define the core function, which centers on inflammatory-vascular signaling.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":16},{"id":"GO:0051209","count":16},{"id":"GO:0071380","count":16},{"id":"GO:0007596","count":16},{"id":"GO:2000724","count":16}]},{"hash":"1174062520633964759","title":"Excitatory Synaptic Transmission and Memory","description":"The most represented terms center on excitatory synaptic signaling and memory formation (excitatory postsynaptic potential, long-term memory, memory), plus ion transport at synapses (calcium and potassium) and regulation of synaptic transmission. Together these suggest proteins functioning at excitatory neuronal synapses involved in learning and memory.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0007616","count":4},{"id":"GO:0006816","count":4},{"id":"GO:0007613","count":3},{"id":"GO:1901998","count":3}]},{"hash":"225311458059448408","title":"Inflammation and tissue remodeling signaling regulators","description":"This cluster shows a mix of regulatory signals related to transcriptional control and immune/tissue remodeling pathways, including BMP response, TNF production, angiogenesis regulation, dendritic cell antigen processing, integrin signaling, fibroblast migration, and chondrocyte proliferation, suggesting a cohesive module governing inflammatory responses and tissue remodeling processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0071773","count":2},{"id":"GO:0010751","count":2},{"id":"GO:0010748","count":2},{"id":"GO:0042535","count":2}]},{"hash":"2035940191990447645","title":"NF-kappaB-driven antiviral innate immunity","description":"This cluster centers on antiviral innate defense and NF-kappaB signaling, with frequent terms for canonical NF-kappaB activation, TNF-mediated signaling, and defense responses to virus. It also includes host-virus interaction processes such as suppression of viral release and intracellular transport of viral material, plus modulating layers like actin ubiquitination and miRNA-mediated gene silencing that support immune responses.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043123","count":15},{"id":"GO:1901253","count":14},{"id":"GO:0051092","count":14},{"id":"GO:1903265","count":14},{"id":"GO:1902187","count":14}]},{"hash":"1586606044754684953","title":"Unknown","description":"The top GO terms span mRNA processing, fat cell differentiation, mechanosensitive responses, telomere maintenance, insulin-related glucose import (obsolete), regulation of CDK activity, cell migration, blood coagulation, and calcium signaling. These functions are diverse and do not point to a single cohesive biological theme, and the cluster has no edges, suggesting heterogeneity rather than a shared function. Therefore, there isn\u2019t a reliable, specific label to assign. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006397","count":6},{"id":"GO:0045444","count":5},{"id":"GO:0035994","count":5},{"id":"GO:0032212","count":5},{"id":"GO:1904355","count":5}]},{"hash":"1953395946251185575","title":"Neural and sensory development with ion transport","description":"The cluster is dominated by terms related to neural and sensory system development and function, such as potassium ion transmembrane transport, axonal fasciculation, neuromast hair cell differentiation, trigeminal nerve organization, and calcium-modulating Wnt signaling. While there are some broader developmental terms (heart, metanephric development) present, the strongest coherent signal ties to nervous system and sensory organ development along with ion transport, justifying a neural/sensory development label with moderate confidence due to some pleiotropic terms.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0007413","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0072205","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1221432414824484301","title":"Innate Immunity and LPS Signaling","description":"The cluster is dominated by GO terms for innate immune response and cellular response to lipopolysaccharide, plus LPS-mediated signaling. A few terms touch on virus response, estrogen signaling, and angiogenesis, but the strongest signal is innate immune recognition of bacterial components, so a name focusing on innate immunity and LPS signaling fits best.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0043627","count":2},{"id":"GO:0032436","count":2}]},{"hash":"1328003644076106193","title":"Lipid Metabolism and Lipoprotein Homeostasis","description":"This cluster is dominated by GO terms tied to triglyceride and cholesterol handling (homeostasis, catabolic processes, lipase regulation), lipoprotein signaling, and lipid digestion. The frequent terms point to a cohesive function in lipid storage, mobilization, and lipoprotein metabolism, rather than other cellular processes. The lack of conflicting terms supports a clear lipid metabolism theme. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070328","count":4},{"id":"GO:0035994","count":3},{"id":"GO:0019433","count":3},{"id":"GO:0010886","count":3},{"id":"GO:0055096","count":3}]},{"hash":"55947025439366793","title":"Membrane repair with autophagy and signaling regulation","description":"This cluster centers on plasma membrane repair, autophagy, and negative regulation of growth signaling (IGF receptor and brassinosteroid pathways), with related ubiquitin-proteasome control, epigenetic regulation, and viral material transport/demethylation terms, suggesting a shared theme of cellular homeostasis through membrane maintenance, turnover control, and gene regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0001778","count":16},{"id":"GO:0043569","count":16},{"id":"GO:0006914","count":15},{"id":"GO:1900458","count":15},{"id":"GO:2000059","count":15}]},{"hash":"1492535175187605882","title":"Transcriptional Regulation and Cell Cycle","description":"The top GO terms are dominated by DNA-templated transcription and mitotic cell cycle, with several entries related to proliferation regulation, suggesting a collection of nuclear regulators controlling gene expression and cell division. Additional terms point to protein\u2013protein interactions and kinase signaling, along with mRNA transport, indicating a broader regulatory nexus rather than a single pathway. This combination supports labeling the cluster as involved in transcriptional control and cell cycle progression.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0070208","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0071456","count":3},{"id":"GO:0051028","count":3}]},{"hash":"523732592356486270","title":"Mammalian embryogenesis and gland morphogenesis","description":"The GO terms point to embryonic development and organ morphogenesis in mammals, including in utero development and trophoblast differentiation, mammary gland duct growth and epithelial proliferation, and salivary gland branching morphogenesis. Additional terms about angiogenesis and regulation of signaling and immune-related activities can accompany developmental processes, though they are less central to a single cohesive function. Overall, the cluster appears to reflect broad developmental and morphogenetic programs rather than a narrow cellular mechanism.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0006958","count":3},{"id":"GO:1902042","count":3}]},{"hash":"2277092700622497255","title":"Cell signaling regulation and proliferation","description":"These proteins appear enriched for terms governing regulation of signaling pathways (negative regulation of protein kinase activity, positive regulation of GTPase activity, NF-kappaB signaling, GPCR-related signaling), along with processes tied to growth and heart development (cell population proliferation, heart development) and transcription/mRNA transport. The combination suggests a cluster of proteins that modulate signaling output to control proliferation and developmental gene expression, rather than a single canonical pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0006469","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0007205","count":4}]},{"hash":"192469121297079487","title":"Ribosome biogenesis and translation; cell cycle","description":"The top GO terms show a strong emphasis on ribosome biogenesis (GO:0042254; GO:0042274) and cytoplasmic translation (GO:0002181), along with tRNA modification (GO:0006400), pointing to components of the protein synthesis machinery. Additionally, cell cycle and cell division terms (GO:0007049; GO:0051301) suggest coordination with cellular growth. Some unrelated terms like DNA transposition and conjugation appear but are less coherent with the main theme, so the label centers on ribosome biogenesis and translation in the context of cell cycle.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0006313","count":3},{"id":"GO:1901001","count":2},{"id":"GO:0000747","count":2}]},{"hash":"1688928313512286176","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030512","count":2},{"id":"GO:2000233","count":1},{"id":"GO:0006203","count":1},{"id":"GO:0046709","count":1},{"id":"GO:0045337","count":1}]},{"hash":"156379910083524567","title":"Developmental growth and metabolic signaling","description":"Top GO terms cluster around organismal development (spinal cord development, skin development, multicellular organism growth) and metabolic/energy signaling (TORC1 signaling, cellular response to glucose starvation), with additional representation of cardiac function and neuronal plasticity (cardiac muscle contraction, long-term synaptic potentiation, memory). This pattern suggests an overarching theme linking development with metabolic regulation and activity-dependent processes, making \u201cDevelopmental growth and metabolic signaling\u201d a concise, representative label. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0007613","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0060291","count":2}]},{"hash":"1827418972438139302","title":"Neural and Inner Ear Development","description":"The most represented terms include brain development, cochlea morphogenesis, inner ear development, and pituitary gland development, indicating a developmental program for neural and sensory organs. Transcriptional regulation terms further support gene expression control in development; some terms like locomotory behavior reflect downstream neural function. The overall theme is cohesive around neurodevelopment and sensory organ morphogenesis, despite some terms being obsolete or less specific.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0007626","count":5},{"id":"GO:0045317","count":5},{"id":"GO:0007420","count":5}]},{"hash":"1247213731465683873","title":"Dendritic development and synaptic plasticity","description":"Top GO terms indicate neuronal development and synaptic regulation, including dendrite development, synapse structural plasticity, and long-term synaptic depression. Several terms point to actin cytoskeleton dynamics and small GTPase signaling, essential for neurite outgrowth and synapse remodeling, reinforced by Wnt signaling modulation of synapses. A few terms reference centrosome localization and tight junction assembly, but they can reflect broader aspects of cell polarity and cytoskeletal organization relevant to neurons. Overall, the cluster seems to aggregate proteins involved in forming and modifying neuronal connections via cytoskeletal and signaling pathways.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051835","count":6},{"id":"GO:0016358","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0060292","count":5},{"id":"GO:0051660","count":5}]},{"hash":"429391205937942478","title":"Unknown","description":"The GO terms span several distinct domains (thrombin signaling, membrane repair, NF-kappaB activity, vision/phototransduction, saliva secretion, inflammatory signaling, etc.), and there are no network connections among the proteins. This lack of a cohesive, single-function theme makes it impossible to assign a meaningful, specific label.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070493","count":3},{"id":"GO:0001778","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0007601","count":2},{"id":"GO:0046541","count":2}]},{"hash":"2179981457095651721","title":"Ribosome biogenesis and cell division","description":"The cluster is dominated by GO terms for ribosome biogenesis and subunit export, ribosomal subunit assembly/biogenesis, and cell-cycle/mitotic division processes, suggesting a function in coordinating ribosome production with cell division.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0000278","count":4},{"id":"GO:1901001","count":4}]},{"hash":"667032086526869743","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":171,"triangles":630,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":9},{"id":"GO:0000398","count":8},{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0010610","count":6}]},{"hash":"44230209944233920","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0000472","count":6},{"id":"GO:0000480","count":6},{"id":"GO:0000447","count":5},{"id":"GO:0000462","count":5}]},{"hash":"1397740744824867485","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0071031","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0060303","count":2}]},{"hash":"1000725592047889510","title":"Cranial neural crest and axon guidance","description":"The terms cluster around neural crest\u2013driven cranial nerve development and axon pathfinding, including trigeminal nerve organization, branchiomotor neuron axon guidance, sympathetic neuron projection guidance, neural crest cell migration, and related morphogen signaling. This points to a cohesive theme of neural crest\u2013mediated cranial nerve development and axon guidance.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021637","count":4},{"id":"GO:0097491","count":4},{"id":"GO:0097490","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0048010","count":4}]},{"hash":"59197012612322252","title":"Neural development and synapse formation","description":"The cluster is dominated by terms related to neural development and brain structures (neuron cell\u2013cell adhesion, brain and cerebral cortex development, inner ear development, locomotory behavior, and positive regulation of synapse assembly), pointing to neural differentiation and synaptogenesis as the core function. A few outlier terms (xenobiotic response, nephron differentiation, and an obsolete histone methylation term) are present but do not negate the overall neural-focused theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007158","count":5},{"id":"GO:0048839","count":5},{"id":"GO:0007420","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0045317","count":4}]},{"hash":"2001987462463723152","title":"Photoreceptor Development and Vision Maintenance","description":"The top GO terms cluster around photoreceptor maintenance, visual perception, and differentiation, indicating a focus on visual system function. The RNA processing and translation terms likely reflect general gene-expression activity in these cells, but the dominant theme is photoreceptor biology.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045494","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0060219","count":2},{"id":"GO:0008380","count":2}]},{"hash":"910429697299992044","title":"Mitochondrial antiviral signaling and apoptosis","description":"The top GO terms cluster around mitochondria-related processes (positive regulation of mitochondrial fission, regulation of outer membrane permeabilization in apoptotic signaling, mitochondrial membrane targeting) together with antiviral/immune responses (cellular response to exogenous dsRNA, positive regulation of defense response to virus by host). This points to a shared function in mitochondria-mediated innate immune signaling and apoptosis; the development-related terms are broader annotations that may reflect pleiotropy or annotation noise rather than a central theme of the cluster.","confidence":"High","size":23,"edges":17,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090141","count":11},{"id":"GO:0007275","count":10},{"id":"GO:0043010","count":9},{"id":"GO:0032464","count":9},{"id":"GO:0002230","count":9}]},{"hash":"1509842039042278647","title":"Glutamatergic synapse function and plasticity","description":"Based on GO terms, the cluster centers on glutamatergic synaptic activity and plasticity, including receptor clustering at synapses, sodium/potassium ion transport across membranes, and glutamatergic synaptic transmission leading to excitatory postsynaptic potentials and long-term plasticity regulation. While a few terms (visual learning, adrenal development) are less directly tied, the dominant signals point to excitatory synapses and their plasticity.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0008542","count":3}]},{"hash":"1496804559395110706","title":"Organ Morphogenesis and Innate Immune Activity","description":"The top GO terms show two main themes: organ development/morphogenesis (metanephric tubule development, distal/proximal tubule morphogenesis, cartilage condensation) and innate immune processes (complement activation via lectin pathway, phagocytosis recognition, basophil activation, leukocyte tethering/rolling, NK cell chemotaxis regulation). The cluster appears to aggregate proteins involved in both developmental remodeling and innate immune signaling, suggesting a dual role or a shared set of extracellular or signaling functions. Given the spread across these areas and the lack of a tight single pathway, the label captures the dominant themes without over-committing to a narrow function.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072287","count":7},{"id":"GO:0001867","count":7},{"id":"GO:0036303","count":7},{"id":"GO:0072237","count":7},{"id":"GO:0001502","count":6}]},{"hash":"401980788286878413","title":"Cardiac Calcium Signaling and Contraction","description":"These GO terms cluster around calcium-dependent cardiac function: detection of calcium ions, regulation of calcium release for heart muscle contraction, AV node action potential regulation, and Purkinje-to-ventricular signaling, all central to excitation-contraction coupling in the heart. The inclusion of epinephrine response and ATPase-coupled calcium transporter regulation supports adrenergic modulation of cardiac activity. A few terms like skin development and ossification are less directly related, but the core signal is calcium-mediated cardiac contraction.","confidence":"High","size":23,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":6},{"id":"GO:0005513","count":6},{"id":"GO:0048741","count":6},{"id":"GO:0071872","count":5},{"id":"GO:0010881","count":5}]},{"hash":"1345920712538712229","title":"Amino acid and cofactor biosynthesis","description":"This cluster centers on biosynthetic and catabolic processes for amino acids (lysine, tyrosine), vitamins (biotin), and heme precursors, with additional signals for fatty acid homeostasis and insulin response. Despite some obsolete terms, the dominant theme is metabolic biosynthesis across amino acids and cofactors, indicating a cohesive metabolic module.","confidence":"Medium","size":23,"edges":192,"triangles":896,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":9},{"id":"GO:0042853","count":7},{"id":"GO:0006783","count":7},{"id":"GO:0033512","count":7},{"id":"GO:0006782","count":7}]},{"hash":"1157456078398338392","title":"Blood coagulation and innate immune activation","description":"The cluster's top GO terms cluster around platelet activation, fibrinolysis, plasminogen activation, and complement activation via the lectin pathway, pointing to hemostasis and innate immunity. Some developmental GO terms appear, which may reflect broader regulatory roles or annotation noise, but the strongest signal is coagulation-related and immune-related processes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":7},{"id":"GO:0030168","count":7},{"id":"GO:0001867","count":7},{"id":"GO:0042730","count":7}]},{"hash":"910831513530585859","title":"Embryogenesis and Organ Morphogenesis","description":"The proteins in this cluster are enriched for embryonic development and organ formation across tissues: in utero embryonic development, heart development (including outflow tract morphogenesis and cardiac muscle cell proliferation), placenta and eye morphogenesis, prostate glandular morphogenesis, and neuron maturation. The presence of DNA-templated transcription supports coordinated developmental gene regulation, suggesting a cohesive role in embryogenesis and organ morphogenesis rather than a single pathway.","confidence":"High","size":23,"edges":9,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0003148","count":6},{"id":"GO:0042551","count":5},{"id":"GO:0001890","count":5}]},{"hash":"1345021202391019779","title":"Golgi Vesicle Trafficking and Exocytosis","description":"This cluster is characterized by GO terms tied to Golgi-centered vesicle trafficking and exocytosis, including synaptic vesicle exocytosis, ER-to-Golgi and intra-Golgi transport, endosome-to-Golgi retrograde transport, and Golgi ribbon formation. While there are hints of neuronal contexts (dendritic spine regulation, Rho signaling), the dominant theme is Golgi-associated vesicle transport and membrane fusion.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016079","count":3},{"id":"GO:0042147","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0042144","count":3},{"id":"GO:0006891","count":3}]},{"hash":"1804518031523553856","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":9},{"id":"GO:1902187","count":9},{"id":"GO:0007014","count":9},{"id":"GO:2000637","count":9},{"id":"GO:0061158","count":9}]},{"hash":"1156648048356096584","title":"Neural development and synapse formation","description":"This cluster is enriched for neural connectivity and development processes: heterophilic and homophilic cell-cell adhesion, synapse assembly, axonal fasciculation, and myelination, pointing to neural development and the establishment of neural networks. While there are a few broader or unrelated terms (e.g., kidney development, symbiont entry), the dominant theme is neuronal adhesion and synapse formation, making this label representative. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0001822","count":5}]},{"hash":"87667820101497737","title":"DNA Integration and Transposition","description":"The cluster is dominated by GO terms for DNA integration, DNA transposition, and RNA-templated DNA biosynthesis, with related signals of proviral latency and virus defense, pointing to mobile genetic element activity and viral-host interactions.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0051607","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0006278","count":3},{"id":"GO:0046718","count":3}]},{"hash":"1608875147738008641","title":"Angiogenic MAPK/TOR signaling","description":"The cluster contains GO terms pointing to pro-angiogenic activity (angiogenesis) and key signaling cascades (ERK/MAPK, TOR signaling) with regulators of small GTPases, plus vesicle trafficking (COPII budding) and chemokine production (MCP-1). This combination suggests a cohesive theme around signaling networks that promote angiogenesis and growth while coordinating intracellular trafficking and inflammatory cues. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0071639","count":2},{"id":"GO:0035234","count":2}]},{"hash":"1346401871706439638","title":"Immune signaling and RNA regulation","description":"Based on the top terms, the cluster centers on modulation of immune signaling pathways (NF-\u03baB, TNF, IL-17) and RNA processing/gene silencing (miRNA metabolism and miRNA-mediated silencing), with additional links to cytoskeletal regulation (Rho signaling, actin ubiquitination) that can influence immune responses. This suggests a cohesive theme around signaling control in immunity coupled with RNA-based regulation, though the diverse terms yield only moderate specificity.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0072089","count":4},{"id":"GO:0010586","count":4},{"id":"GO:1903883","count":4},{"id":"GO:0001519","count":4}]},{"hash":"373066086354074228","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0051092","count":7},{"id":"GO:0051607","count":7},{"id":"GO:0007014","count":6},{"id":"GO:2000637","count":6}]},{"hash":"1850702342916928005","title":"Gene Regulation and Autophagy","description":"This cluster centers on regulatory processes governing gene expression and cellular turnover, highlighted by autophagy, epigenetic programming, and inhibition of protein degradation, with supporting links to immune signaling (NF-kappaB/MHC I). Despite some organism-specific terms, the dominant theme is regulation of transcriptional programs and protein homeostasis.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0006914","count":3},{"id":"GO:1900458","count":3},{"id":"GO:2000059","count":3},{"id":"GO:0060669","count":3}]},{"hash":"809084997293735150","title":"Neurodevelopment and neuronal maintenance","description":"This cluster is dominated by brain development, neural tube closure, and neuron apoptotic processes, with supporting terms for microtubule-based movement and protein synthesis/turnover, suggesting a coherent focus on neurodevelopment and neuronal maintenance; a few outliers (defense response, aging) exist but do not outweigh the neurodevelopmental theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000209","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0007018","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0071560","count":3}]},{"hash":"1452083018692543879","title":"Neural development and synaptic organization","description":"Most GO terms cluster around neural development and synaptic processes: neurogenesis, synapse organization/assembly, axonal fasciculation, dendritic spine regulation, and ERK signaling. While a few terms reference organ development (heart/kidney), the dominant theme is neuronal differentiation and synaptic connectivity, suggesting this cluster represents neurodevelopmental and synaptic maturation functions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0061000","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0014068","count":6},{"id":"GO:0050808","count":6}]},{"hash":"744785587408734771","title":"Regulated Signaling and Metabolic Pathways","description":"The top GO terms point to broad regulatory roles across signaling (ERK cascade), cell-cycle control (G1/S transition), vascular permeability, immune cell movement, and various metabolic/xenobiotic processes (vitamin D response, epoxygenase CYP pathways, xenobiotic catabolism). This suggests the proteins function as regulators across diverse pathways rather than a single, cohesive process. A few terms (e.g., vancomycin biosynthetic process) may reflect annotation noise. ","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0043116","count":4},{"id":"GO:0035865","count":4},{"id":"GO:1900087","count":4}]},{"hash":"868501564510141239","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007014","count":4},{"id":"GO:0018032","count":4},{"id":"GO:2000637","count":4}]},{"hash":"61279086939186959","title":"Mitochondrial Transport & Metabolic Regulation","description":"Top GO terms point to mitochondria: transport of citrate, NAD, pyrimidine nucleotides, and ornithine across membranes, the malate-aspartate shuttle, and mitochondrial membrane fission, with regulatory signals including insulin, IGF, amino acid starvation, and vitamin D response. The common thread is a set of proteins involved in mitochondrial transport and energy/metabolic regulation rather than a single pathway, justifying a label centered on mitochondrial transport and metabolism. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034198","count":5},{"id":"GO:0033280","count":4},{"id":"GO:1990519","count":4},{"id":"GO:0000066","count":4},{"id":"GO:0043490","count":4}]},{"hash":"2192426718466670643","title":"Inflammation and immune activation with development","description":"The top GO terms show strong involvement in immune and inflammatory processes (phagocytosis recognition; leukocyte tethering/rolling; basophil and platelet activation; arachidonate secretion; NK cell chemotaxis regulation; response to fungal origin). Some terms also point to developmental morphogenesis (cartilage condensation; mesonephric duct and metanephric tubule development). This pattern suggests proteins participating in immune/inflammatory signaling while also relating to developmental pathways, indicating multifunctional roles across these processes.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":23},{"id":"GO:0006910","count":23},{"id":"GO:0010572","count":23},{"id":"GO:0045575","count":23},{"id":"GO:0050901","count":23}]},{"hash":"109427089605533494","title":"Fatty acid metabolism and lipid biosynthesis","description":"The top GO terms cluster around fatty acid metabolism and biosynthesis (long-chain/medium-chain fatty acids, fatty acid biosynthetic/metabolic processes, and related import). While a few terms touch on other lipid or secondary metabolite pathways, the dominant signal is lipid metabolism, justifying a label focused on fatty acids and lipid biosynthesis.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0090410","count":4},{"id":"GO:0044539","count":4},{"id":"GO:0009698","count":4},{"id":"GO:0036112","count":4},{"id":"GO:0010030","count":4}]},{"hash":"1096173215956256339","title":"Coagulation, Fibrinolysis, and ECM Remodeling","description":"The cluster is dominated by GO terms for blood coagulation, plasminogen activation, and regulation of fibrinolysis, with supporting terms for extracellular matrix disassembly and mononuclear cell migration, implying a cohesive theme around hemostasis-associated ECM remodeling and related signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0042730","count":5},{"id":"GO:1902042","count":4},{"id":"GO:0031639","count":4},{"id":"GO:0021707","count":3}]},{"hash":"1229750141300522030","title":"Inflammation and leukocyte recruitment","description":"The top GO terms cluster around innate immune and inflammatory processes: positive regulation of chemokine production, leukocyte tethering or rolling, phagocytosis recognition, production of inflammatory mediators, and activation of platelets and basophils. These collectively indicate a module involved in immune cell recruitment and inflammatory signaling, with some metabolic or developmental terms present that are less central to this theme (e.g., endosomal acidification, carbohydrate/chitin-related processes). Overall, the cluster seems best described by inflammatory and leukocyte recruitment functions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0090197","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0006032","count":3},{"id":"GO:0002532","count":3},{"id":"GO:0050901","count":2}]},{"hash":"718245359458536425","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":16},{"id":"GO:0007014","count":16},{"id":"GO:2000637","count":16},{"id":"GO:0061158","count":16},{"id":"GO:0072089","count":12}]},{"hash":"597726701009103737","title":"Transposon activity and genome remodeling","description":"The top GO terms are dominated by DNA transposition and DNA integration, pointing to transposable elements and genome rearrangements as the central theme of this cluster. Other terms like apoptosis, aging, and responses to xenobiotics or LPS may reflect stress-related cellular states associated with genome instability, but the strongest signal is transposon-related activity.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0090305","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0097194","count":2}]},{"hash":"711700238504164925","title":"Plasminogen Activation and Fibrinolysis","description":"This cluster is dominated by plasminogen activation and fibrinolysis terms, indicating a core role in extracellular remodeling and clot dissolution. Additional terms on integrin-regulated cell adhesion, inflammatory cytokine regulation, and signaling cascades (JNK/ERK) alongside development terms (liver development, trophoblast differentiation) suggest broader involvement in tissue remodeling and development processes. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":5},{"id":"GO:0042730","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0033628","count":4},{"id":"GO:0032715","count":4}]},{"hash":"1247663236784687372","title":"Unknown","description":"The Top Terms span diverse developmental and biological contexts (brain region development, cell morphogenesis, transcription regulation, immune isotype switching, DNA damage signaling, adipose development), with no single cohesive function tying the proteins together. The lack of interconnected edges reinforces the absence of a unifying pathway, supporting an Unknown label.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000902","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0033138","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0021794","count":2}]},{"hash":"2118269492411310806","title":"Innate immune signaling and macrophage activation","description":"Proteins in this cluster are enriched for innate immune and inflammatory terms: Toll signaling pathway, NF-kappaB regulation, innate immune response, macrophage activation, dendritic cell cytokine production, and defense against Gram-positive bacteria, along with interferon signaling. This suggests a cohesive role in innate immune activation and antigen-presenting cell function, with actin dynamics potentially supporting cell movement and phagocytosis. One plant-related term about meristem organization appears as an outlier, but the dominant theme is clear.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008063","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0002730","count":3},{"id":"GO:0050830","count":3}]},{"hash":"1911245205536927784","title":"Unknown","description":"The top terms span immune defense (complement activation, phagolysosome assembly), development (eye morphogenesis, synapse and junction-related processes), and cell migration/adhesion, with no single coherent function tying the proteins together. Therefore there is no clear thematic label beyond Unknown.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0090528","count":3},{"id":"GO:0048593","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0034115","count":2}]},{"hash":"2196975590239424476","title":"Unknown","description":"The top GO terms are scattered across diverse metabolic processes (beta-ketoadipate pathway, triglyceride catabolic process, biotin biosynthesis, nitrogen utilization, uracil catabolic process, cellular oxidant detoxification) and include several obsolete terms. There is no clear single function or shared pathway that ties all 23 proteins together, suggesting the cluster does not represent a cohesive biological theme. Confidence in a specific, representative label is therefore None.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042952","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0019740","count":1},{"id":"GO:0009086","count":1}]},{"hash":"1475565210181664897","title":"Ubiquitin-Dependent Protein Turnover & NF-kB Signaling","description":"The cluster\u2019s top GO terms center on ubiquitin-dependent protein catabolic processes and ubiquitination (including K6-linked ubiquitination), plus activation of NF-kappaB signaling and regulation of apoptosis. Additional terms reference TNF-mediated signaling and immune-related processes (e.g., antiviral transport regulation, V(D)J recombination), suggesting a cohesive module where ubiquitin-mediated regulation governs immune signaling and cell fate. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:1901253","count":10},{"id":"GO:1903265","count":10},{"id":"GO:1903762","count":10},{"id":"GO:0051865","count":10}]},{"hash":"1190538071094328426","title":"Antiviral innate immunity and antigen presentation","description":"Proteins in this cluster are enriched for innate antiviral defense terms, including defense response to virus, innate immune response, and positive regulation of NF-kappaB signaling, along with positive regulation of MHC class I biosynthesis. The presence of autophagy further supports a coordinated antiviral response linking signaling, antigen processing, and trafficking. This combination suggests a cohesive antiviral immune module.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0046598","count":11},{"id":"GO:0043123","count":11},{"id":"GO:0045345","count":11},{"id":"GO:0051607","count":11},{"id":"GO:0045087","count":11}]},{"hash":"983518905771886445","title":"Neural development and synaptic signaling","description":"The terms cluster around neural development and neuronal signaling, including brain development, synaptic transmission regulation, serotonin metabolism, and receptor trafficking/clustering, with potassium transport supporting neuronal excitability, suggesting a cohesive neural development/synaptic regulation theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:1902742","count":2},{"id":"GO:0071805","count":1},{"id":"GO:0050806","count":1},{"id":"GO:0030818","count":1}]},{"hash":"1223585728977656616","title":"Unknown","description":"The top GO terms span iron-sulfur cluster biology (2Fe-2S assembly and iron-related transcription regulation) but also include membrane potential regulation, calcium release, prostaglandin response, and inflammatory cytokine production. With no edges connecting the proteins, there isn't a single coherent function or pathway that ties the members together. The mixture suggests either annotation noise or a very broad set of unrelated roles, making a precise label unreliable.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042391","count":2},{"id":"GO:1903026","count":1},{"id":"GO:0044571","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0034396","count":1}]},{"hash":"582095439060816185","title":"Cholesterol homeostasis and transport","description":"The top GO terms are dominated by cholesterol-related processes\u2014intestinal cholesterol absorption, cholesterol homeostasis, cholesterol efflux, and cellular response to cholesterol\u2014indicating a core theme of cholesterol metabolism. Some development terms appear, but the cholesterol-related terms provide the strongest, direct connection to the cluster\u2019s function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030299","count":7},{"id":"GO:0042633","count":6},{"id":"GO:0042632","count":6},{"id":"GO:0060037","count":6},{"id":"GO:0071397","count":6}]},{"hash":"642478899463232744","title":"Diverse Transmembrane Transporters","description":"GO terms indicate a broad set of transmembrane transport activities across membranes, spanning substrates such as xenobiotics, nitrite, potassium, phosphate, sugars (arabinose), sialic acid, vitamins, and other compounds. The common thread is membrane transport rather than a single pathway, suggesting this cluster consists of diverse membrane transporter proteins with varied substrates.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0015739","count":2}]},{"hash":"183297084063095887","title":"Axon Extension and Neuron Migration","description":"The dominant GO terms indicate neuronal development events\u2014axon extension and neuron migration\u2014with supporting roles in forebrain neuroblast division and cytoskeletal transport along actin. Signaling pathways such as VEGF and Wnt regulation also connect to neurite outgrowth and cell migration, reinforcing the neuronal-development theme. A few terms (peroxisome inheritance) are less central but do not negate the overall pattern.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048675","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0021873","count":1},{"id":"GO:0051661","count":1},{"id":"GO:0045033","count":1}]},{"hash":"275363729223768716","title":"Leukocyte signaling and adhesion","description":"This cluster is enriched for immune signaling terms (B cell receptor signaling, neutrophil chemotaxis, NK cell cytotoxicity) and adhesion-related processes (integrin signaling, epithelial cell\u2013cell adhesion, zonula adherens maintenance), suggesting proteins involved in leukocyte communication and cell\u2013cell/matrix adhesion.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:0030593","count":2},{"id":"GO:0045218","count":2},{"id":"GO:0034453","count":2},{"id":"GO:0007229","count":2}]},{"hash":"947862149643456162","title":"Antiviral NF-kappaB Signaling and Autophagy","description":"This cluster is dominated by GO terms tied to defense against viruses and regulation of NF-kappaB signaling (e.g., defense response to virus; positive regulation of canonical NF-kappaB signaling; NF-kappaB transcription factor activity). Autophagy is also represented, which often interfaces with antiviral responses and can be co-regulated with NF-kappaB pathways. A few terms appear unrelated (e.g., placenta morphogenesis), but the core theme centers on antiviral defense and NF-kappaB\u2013mediated regulation, possibly with modulation of ubiquitin-dependent degradation. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0090073","count":3},{"id":"GO:0006914","count":3}]},{"hash":"93761649403422098","title":"Innate immune activation and leukocyte trafficking","description":"Most terms cluster around innate immunity and inflammation: complement activation (lectin pathway), phagocytosis, leukocyte tethering/rolling, basophil activation, NK cell chemotaxis regulation, and response to fungal molecules. Some developmental terms may reflect pleiotropy of certain proteins, but the dominant signal is innate immune activation and leukocyte movement.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":16},{"id":"GO:0001502","count":13},{"id":"GO:0006910","count":13},{"id":"GO:0010572","count":13},{"id":"GO:0045575","count":13}]},{"hash":"693936463568791309","title":"Neural development and ion-channel signaling","description":"The most represented GO terms point to neural processes: potassium ion transmembrane transport, membrane hyperpolarization, and cellular response to cAMP, together with neuromuscular junction development. These, plus camera-type eye morphogenesis, suggest a theme of neural signaling and development mediated by ion channels and GPCR-related pathways. A few terms related to chemokine production are present but do not fit as cleanly; overall the cluster seems best described by neural development and ion-channel signaling.","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0071320","count":2},{"id":"GO:0048593","count":2},{"id":"GO:0060081","count":2},{"id":"GO:2000340","count":2}]},{"hash":"633679483145979795","title":"Pain signaling and dopaminergic/GABAergic neurotransmission","description":"The cluster centers on neural signaling and pain modulation, highlighted by terms for sensory perception of pain, morphine response, and regulation of dopamine and GABAergic synaptic transmission. Additional terms point to metabolic and inflammatory context (thermogenesis, prostaglandin response) that can influence neural activity, with a couple of broader terms (heart development, macrophage chemotaxis) suggesting incidental or broader systemic connections. Overall, the dominant theme is neural communication and pain modulation, with supportive metabolic and inflammatory cues.","confidence":"Medium","size":22,"edges":36,"triangles":5,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0071380","count":8},{"id":"GO:0008542","count":8}]},{"hash":"910408904590443696","title":"Platelet activation and actin remodeling","description":"The top GO terms cluster around platelet-related processes and actin cytoskeleton dynamics: lamellipodium assembly, actin filament severing, cytoplasmic actin-based contraction and integrin signaling, as well as platelet secretion and aggregation. Together these point to platelet activation coupled with actin-driven adhesion, spreading, and signaling. An outlier term like intestinal glucose absorption is noted but does not override the dominant platelet\u2013cytoskeleton theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090315","count":1},{"id":"GO:0032532","count":1},{"id":"GO:0070560","count":1},{"id":"GO:0060327","count":1},{"id":"GO:1900025","count":1}]},{"hash":"1077396726718717218","title":"Transmembrane Transporters","description":"Top GO terms are all about transmembrane transport, including potassium and sodium ion transport, nitrite and phosphate transport, and various nutrient and xenobiotic transports, indicating a cluster of membrane transporter proteins with diverse substrates. This pattern suggests a coherent theme of membrane transport activity across many substrates, justifying the label Transmembrane Transporters.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0006855","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0035435","count":2}]},{"hash":"659670575247395043","title":"Membrane Transporters (Various Substrates)","description":"The top GO terms show transmembrane transport for a wide range of substrates (ions, sugars, vitamins, aromatic compounds, etc.), indicating these proteins are broadly involved in membrane transport rather than a single substrate or pathway.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0015757","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0015751","count":2}]},{"hash":"845168501249467554","title":"Spermatogenesis and Transcription Regulation","description":"The cluster shows clear enrichment for male germ cell development and spermatogenesis (single fertilization, spermatogenesis, male gonad development) together with multiple transcriptional regulatory processes (DNA-templated transcription, negative regulation of transcription by RNA polymerase II, negative regulation of mRNA splicing, and regulation of nuclear export). This combination suggests a cohesive theme around transcriptional control during spermatogenesis, with some ancillary stress-related terms likely reflecting broader regulatory roles. ","confidence":"Medium","size":22,"edges":95,"triangles":187,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0008285","count":3}]},{"hash":"1587462708176992089","title":"Unknown","description":"The GO terms are highly diverse (bioluminescence, hypoxia response, GTPase regulation, mitosis, synaptic plasticity, somitogenesis, coagulation, cell adhesion, detoxification, and metabolism), with no coherent shared function or pathway. The lack of interaction evidence further suggests there isn\u2019t a single representative theme linking these proteins.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008218","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0031915","count":3}]},{"hash":"320772534683391102","title":"Embryonic organogenesis and tissue morphogenesis","description":"The top GO terms point to developmental processes during embryogenesis: pancreatic cell development, trophoblast differentiation, left-right patterning, cartilage morphogenesis, placental development, and EMT in heart development, along with endocrine system development. These collectively indicate a theme of embryo-driven organ formation and tissue structuring. A couple of terms (complement activation and regulation of platelet aggregation) are less connected to development and may be ancillary. Overall, the cluster appears to represent embryonic organogenesis and tissue morphogenesis.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0001867","count":5},{"id":"GO:0090331","count":5},{"id":"GO:0030199","count":5}]},{"hash":"174577169919630170","title":"PNS axon guidance and paranodal junction formation","description":"This cluster is enriched for nervous system development terms, especially axon guidance and the formation of specialized axonal domains. Prominent terms include motor neuron axon guidance, peripheral nervous system neuron axonogenesis, axon extension in guidance, and paranodal/juxtaparanode localization, pointing to roles in PNS axon pathfinding and paranodal junction formation. Some terms about general morphogenesis appear but do not outweigh the neuronal wiring signal.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0030913","count":9},{"id":"GO:0014909","count":9},{"id":"GO:0060982","count":9},{"id":"GO:0071205","count":9}]},{"hash":"335926925327096577","title":"Cellular stress response and cell cycle regulation","description":"The top GO terms point to stress response pathways (cadmium ion exposure, hydrogen peroxide, unfolded protein) alongside cell cycle processes (mitotic cell cycle, cell division), with additional signals from innate immunity and transcription. Together they suggest a cluster of proteins involved in coordinating stress signaling with cell proliferation, albeit with some breadth in terms. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0070301","count":6},{"id":"GO:0019233","count":5}]},{"hash":"1048562045376717497","title":"Angiogenesis Signaling Regulation","description":"The top GO terms cluster around regulation of signaling pathways involved in angiogenesis (negative regulation of VEGF receptor signaling, negative regulation of PDGFR signaling, and sprouting angiogenesis), as well as vascular-related processes like blood coagulation. This suggests a cohesive theme of modulating vascular signaling and angiogenic balance, with a few peripheral terms (eye morphogenesis, glycogen/aldosterone-related regulation) that may reflect broader signaling roles but are not central to the cluster. Confidence: Medium","confidence":"","size":22,"edges":30,"triangles":9,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":4},{"id":"GO:0045725","count":4},{"id":"GO:2000860","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0070543","count":3}]},{"hash":"218739291873781333","title":"Neuronal adhesion and axon guidance","description":"The cluster is enriched for nervous system development, axon guidance (Roundabout signaling), paranode-localized proteins, dendrite self-avoidance, and cell\u2013cell adhesion terms, pointing to neuronal patterning and connectivity. Some bone/muscle-related terms appear but are less representative of the dominant neural theme. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002175","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0045214","count":5},{"id":"GO:0007156","count":5}]},{"hash":"172715538438526561","title":"GPCR signaling and lipid metabolism","description":"This cluster features GO terms centered on GPCR-driven signaling (e.g., adenylate cyclase-activating adrenergic receptor signaling), receptor internalization, and processes like macrophage chemotaxis and angiogenesis, alongside cholesterol biosynthesis. The strongest common theme appears to be membrane-associated signaling and lipid metabolism, with downstream effects on immune/vascular signaling and neuronal regulation, despite some heterogeneous terms. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0009636","count":5},{"id":"GO:0006695","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0031623","count":4},{"id":"GO:0017000","count":4}]},{"hash":"2021123261844580355","title":"GPCR-Mediated Cardiovascular Signaling","description":"This cluster is dominated by GO terms tied to adenylate cyclase-activating GPCR signaling, prostaglandin response, calcium release, and blood pressure regulation, all central to cardiovascular function and vascular smooth muscle activity. Additional terms on coagulation and cardiac vascular smooth muscle differentiation reinforce a vascular/regulatory theme, while the electron transport chain and a few outliers (grooming behavior, obsolete viral suppression) appear ancillary or noise. Overall, the common thread is signaling pathways that govern cardiovascular tone, vascular response, and associated inflammatory mediators. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0045777","count":17},{"id":"GO:0032651","count":16},{"id":"GO:0051209","count":16}]},{"hash":"1284070343082707843","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902187","count":6},{"id":"GO:0007014","count":6},{"id":"GO:2000637","count":6},{"id":"GO:0061158","count":6},{"id":"GO:0072089","count":5}]},{"hash":"1386584742671421274","title":"Unknown","description":"The top GO terms are highly diverse, including responses to morphine, lead ions, and hydrogen peroxide; regulation of GPCR signaling; cell division and centrosome maintenance; peptidyl-tyrosine sulfation; and gluconeogenesis. There is no single cohesive function or pathway tying these terms together, and the lack of edges suggests no detectable functional module. Therefore, a concise, representative label cannot be determined.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043278","count":5},{"id":"GO:2000531","count":3},{"id":"GO:0008277","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006478","count":3}]},{"hash":"1167244429991246488","title":"NF-kB-driven antiviral innate immunity","description":"The cluster shows strong enrichment for innate immune response, defense response to virus, and NF-kappaB signaling terms, with autophagy also prominent, suggesting a coordinated antiviral innate immunity role governed by NF-\u03baB. A few terms (e.g., brassinosteroid signaling and placenta morphogenesis) may reflect annotation noise or cross-talk, but the core theme is coherent.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":19},{"id":"GO:0051092","count":18},{"id":"GO:0051607","count":18},{"id":"GO:0043123","count":18},{"id":"GO:0006914","count":17}]},{"hash":"191580192811634135","title":"Neuronal excitability and neurotransmission","description":"The top GO terms highlight ion transport, membrane depolarization, and excitatory postsynaptic potentials, pointing to neuronal excitability and synaptic signaling. Additional terms involve serotonin receptor signaling and dopamine secretion regulation, tying neuromodulation to autonomic control of heart rate. Developmental terms for brain regions (LGN, vestibulocochlear nerve) and locomotory behavior also align with neural function. Overall, the cluster centers on neural signaling and excitability.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0051899","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0007210","count":3}]},{"hash":"308900008517579460","title":"Transcription and apoptosis-related proteins","description":"This cluster's top GO terms cluster around DNA-templated transcription and multiple apoptotic processes across different cell types (hepatocytes, neurons, glial cells), with some hints of cell cycle involvement. Although there are a few transport-related terms, the dominant signal is transcriptional regulation coupled with programmed cell death, suggesting the proteins collectively participate in gene expression control and apoptosis pathways.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051568","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0097284","count":2},{"id":"GO:0051402","count":2}]},{"hash":"2253877102651923112","title":"Ubiquitin-Dependent Protein Degradation and Regulation","description":"The cluster is dominated by ubiquitination-related GO terms (polyubiquitination, ubiquitin-dependent ERAD, protein catabolic processes, autoubiquitination, histone H2A ubiquitination) and related regulatory roles (transcription, cell cycle, TNF signaling), pointing to a cohesive theme of ubiquitin-mediated protein turnover and its regulatory effects.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:1901253","count":8},{"id":"GO:0030433","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0000209","count":8}]},{"hash":"156337227136426365","title":"Unknown","description":"The terms cover muscle stretch response, cold response, mRNA processing, lipid catabolism, complement activation, calcium ion release, stem cell proliferation, and endothelial chemotaxis\u2014diverse processes with no single dominant theme. Therefore a coherent cluster label cannot be assigned.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0009409","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0019433","count":3}]},{"hash":"928609331189834520","title":"Thermogenesis-Linked Temperature Signaling","description":"The top GO terms cluster around thermogenesis and temperature response (diet-induced thermogenesis, cellular response to temperature stimulus) and signaling pathways such as GPCR-mediated adenylate cyclase signaling, calcium release, and Rho signaling, which together suggest temperature-driven metabolic and signaling adaptation. Additional terms touching skin development, blood pressure, angiogenesis, and pain indicate supportive roles in skin and vascular responses to thermal stress. Overall, the cluster seems to reflect a cohesive theme of thermogenesis-related signaling with ancillary skin/vascular context.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035025","count":8},{"id":"GO:0051209","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0019233","count":6}]},{"hash":"1542405432486434711","title":"Unknown","description":"The GO terms include spermatogenesis and intestinal epithelial cell development alongside several membrane transport and vesicle trafficking processes, with no clear single function uniting the cluster. The absence of a cohesive theme makes Unknown the most appropriate label.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007283","count":3},{"id":"GO:0060576","count":1},{"id":"GO:0060628","count":1},{"id":"GO:0046360","count":1},{"id":"GO:0044690","count":1}]},{"hash":"1166147989100853268","title":"Ubiquitin signaling and stress response","description":"The GO terms show a strong emphasis on ubiquitination and deubiquitination (K6- and K29-linked), indicating a core role for ubiquitin-mediated regulation. Additional terms involve stress and immune signaling modulation (hypoxia response, negative regulation of TLR3 signaling, extrinsic apoptotic pathway regulation) and supportive developmental/cell-cycle terms, suggesting a broader regulatory network centered on ubiquitin-dependent control of stress responses and immune signaling. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0071456","count":2},{"id":"GO:0048143","count":2},{"id":"GO:1903799","count":2},{"id":"GO:0048741","count":2}]},{"hash":"226915149593983722","title":"Developmental Apoptosis and Immune Signaling","description":"The top GO terms point to development-related processes (thymus and forebrain development, multicellular growth) alongside apoptotic pathways (extrinsic death receptor signaling, neuron and B cell apoptosis) and immune signaling (IL-5/IL-13 production). This suggests the proteins are involved in apoptosis within developmental and immune contexts rather than a single isolated function, justifying a label that combines development, apoptosis, and immune signaling. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048538","count":4},{"id":"GO:0051402","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0008625","count":3}]},{"hash":"46133136894353799","title":"TLR-driven innate immune activation","description":"The cluster shows a strong enrichment for innate immune and inflammatory terms: detection of LPS, TLR10 signaling, macrophage activation, inflammatory response, and defense against bacteria, suggesting an innate immune sensing and activation module. Some additional terms (axon extension, kidney size) are less central, but the core pattern supports a TLR-mediated immune/inflammatory function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048846","count":3},{"id":"GO:0032497","count":2},{"id":"GO:0002730","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0042116","count":2}]},{"hash":"1335483453419815770","title":"Transcriptional Regulation with Proteostasis","description":"This cluster centers on transcription-related processes (DNA-templated transcription and positive regulation of transcription by RNA Pol II) and protein homeostasis (SCF-dependent ubiquitin-proteasome degradation and polyubiquitination), with supporting signals of growth and muscle differentiation. While some stress/defense terms are present, the dominant common theme appears to be regulation of gene expression together with protein turnover, especially in developmental contexts.","confidence":"Medium","size":21,"edges":7,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0035914","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0031146","count":2}]},{"hash":"1811625814001542345","title":"ECM Remodeling and Vascular Adhesion","description":"The cluster is dominated by GO terms tied to extracellular matrix dynamics and cell\u2013matrix interactions (hyaluronan metabolism, negative regulation of ECM assembly, calcium-independent cell-matrix adhesion, heterotypic cell\u2013cell adhesion, and cellular extravasation). Coagulation and complement activation terms further point to vascular/inflammatory processes interacting with the ECM. Some terms like DNA replication or dendrite regeneration appear less aligned and may be noise, but the ECM/adhesion/coagulation theme is strong overall. ","confidence":"High","size":21,"edges":51,"triangles":19,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070208","count":7},{"id":"GO:0006260","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0030212","count":5},{"id":"GO:0045123","count":5}]},{"hash":"234907698133790355","title":"Organogenesis and Tissue Morphogenesis","description":"The top GO terms cluster around developmental processes across multiple organs (nephron morphogenesis, S-shaped body morphogenesis, umbilical cord morphogenesis, lung vasculature development, pancreatic cell fate commitment), indicating a common theme of organogenesis and tissue differentiation. A few terms touch on general cellular responses (e.g., xenobiotic response, DNA repair), but the dominant signal supports a developmental morphogenesis focus.","confidence":"Medium","size":21,"edges":104,"triangles":327,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003326","count":11},{"id":"GO:0003053","count":11},{"id":"GO:0048712","count":11},{"id":"GO:0071400","count":11},{"id":"GO:0009410","count":11}]},{"hash":"536121517198869793","title":"Cardiac conduction system development","description":"The top GO terms center on heart-specific processes: regulation of SA node and atrial/Purkinje signaling, outflow tract morphogenesis, and cardiac hypertrophy responses, all pointing to cardiac development and the heart\u2019s conduction system. Some non-cardiac terms (skin development, ossification, pancreatic cell apoptosis) may reflect pleiotropy or broader developmental roles, but the dominant signal is cardiac formation and electrophysiology, supporting this label.","confidence":"High","size":21,"edges":36,"triangles":31,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098907","count":9},{"id":"GO:1903244","count":8},{"id":"GO:0043588","count":7},{"id":"GO:0043931","count":7},{"id":"GO:0086029","count":7}]},{"hash":"960086830112237883","title":"Cardiac development and junctional signaling","description":"The top GO terms point to heart development and regulation/assembly of cell\u2013cell junctions (tight and adherens junctions), along with related signaling and apoptosis (e.g., JNK cascade). This suggests proteins involved in cardiac tissue formation/remodeling and junctional regulation. Some terms like adaptive immune response or synapse plasticity appear as broader annotations but do not override the main cardiac/junctional theme. ","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046328","count":4},{"id":"GO:0070830","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0002250","count":3}]},{"hash":"1061548530836920579","title":"Cerebellar neural development and signaling","description":"The top terms cluster around cerebellar development and neural signaling: cerebellar cortex formation, Bergmann glial cell differentiation, regulation of axon regeneration, and integrin-mediated signaling. While DNA replication and DNA-templated transcription are also present, they are broad housekeeping processes that don\u2019t define the cluster\u2019s function. Overall, the set appears focused on cerebellar neural development and related signaling pathways.","confidence":"Medium","size":21,"edges":39,"triangles":34,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0008285","count":6},{"id":"GO:0007229","count":4},{"id":"GO:0021697","count":4},{"id":"GO:0048679","count":4}]},{"hash":"706699513080195909","title":"Neural development with immune-vascular signaling regulation","description":"This cluster is enriched for neural/sensory development terms (inner ear development; positive regulation of synapse assembly) and for immune/vascular signaling modulation (negative regulation of ERK1/ERK2 cascade; negative regulation of VEGF receptor signaling; negative regulation of macrophage differentiation; monocyte chemotactic protein-1 production; blood coagulation). Additional terms point to endocrine and lipid signaling (positive regulation of aldosterone secretion; response to linoleic acid). Together, these suggest a theme of neural development coupled with immune and vascular signaling control.","confidence":"Medium","size":21,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0071639","count":4},{"id":"GO:0030948","count":4},{"id":"GO:0070373","count":4}]},{"hash":"173975660951049795","title":"Innate Immune Signaling and Leukocyte Activation","description":"This cluster is dominated by GO terms tied to innate immune recognition and activation, including C-type lectin receptor signaling, phagocytosis, basophil activation, and leukocyte tethering/rolling, as well as cellular responses to fungal origin. While a few development-related terms appear, the core theme centers on innate immune signaling and leukocyte activation rather than a single developmental pathway.","confidence":"High","size":21,"edges":129,"triangles":477,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":7},{"id":"GO:0001502","count":6},{"id":"GO:0006910","count":6},{"id":"GO:0010572","count":6},{"id":"GO:0045575","count":6}]},{"hash":"675185275327443574","title":"Hippo and neurotrophin developmental signaling","description":"The top GO terms indicate a convergence on developmental signaling, particularly Hippo pathway activity and neurotrophin TRK signaling, with linked heart and hippocampus development. While other terms relate to cell cycle, protein processing, and stress or immune responses, the dominant theme is developmental growth and neural development.","confidence":"Medium","size":21,"edges":27,"triangles":14,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035329","count":5},{"id":"GO:0048011","count":5},{"id":"GO:0051321","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0045736","count":5}]},{"hash":"1544991665129973422","title":"Signaling and Motility Regulation","description":"This cluster shows enrichment for terms related to regulation of signaling pathways (integrin-mediated signaling, canonical Wnt signaling, NF-kappaB), GTPase activity, and cell motility, with additional hints from cell cycle and neuron development. The inclusion of lysosome localization and proteasome assembly suggests coordinated protein turnover and trafficking to support signaling and cytoskeletal dynamics. Together, these imply a group of proteins that modulate signaling networks to control cell movement and adhesion.","confidence":"Medium","size":21,"edges":20,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0061462","count":3},{"id":"GO:0043248","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1285870376715172185","title":"Developmental adhesion and signaling","description":"This cluster\u2019s top GO terms cluster around functions in tissue development and cell interactions: leukocyte tethering/rolling and cell-matrix adhesion point to adhesion and trafficking; epithelial palatal shelf morphogenesis, smooth muscle migration, and metanephric limb development indicate morphogenesis and cell movement; Notch signaling regulation and ganglioside metabolism relate to developmental signaling and lipid-mediated modulation of signaling; the presence of synaptic transmission terms may reflect shared signaling mechanisms in neural development. Taken together, the proteins appear to converge on developmental processes governed by adhesion and signaling rather than a single, narrow pathway.","confidence":"Medium","size":21,"edges":32,"triangles":10,"max_degree":9,"top_function":"wound healing","top_go_terms":[{"id":"GO:0050901","count":11},{"id":"GO:0051968","count":8},{"id":"GO:1990134","count":8},{"id":"GO:0007161","count":8},{"id":"GO:0014909","count":8}]},{"hash":"1389148156858761062","title":"Developmental muscle, heart, vascular morphogenesis and neural guidance","description":"The GO terms cluster around developmental processes affecting muscle (skeletal muscle fiber development), heart development, and vascular branching, along with neural pathfinding and axon guidance (sympathetic and branchiomotor neurons, axonal fasciculation). This suggests a shared theme of coordinated morphogenesis across muscle, heart, vessels, and nervous system, with some signaling modulation (MAPK/ERK) and ion channel organization implicated. Overall, a cohesive developmental program across multiple tissues fits best, hence this label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0045163","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0001569","count":2}]},{"hash":"1445898184672343824","title":"Neuronal signaling and synaptic plasticity","description":"Top terms cluster around dendrite development, glutamate secretion, synapse structural plasticity, and neuromodulatory signaling, with supporting roles for protein dephosphorylation. While there are a couple of epithelial/polarity-related terms, the dominant pattern is neuronal communication and synaptic modulation, indicating a neuron-focused cluster involved in signaling and plasticity.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070433","count":4},{"id":"GO:0016358","count":4},{"id":"GO:0090557","count":4},{"id":"GO:0006470","count":4},{"id":"GO:0008285","count":4}]},{"hash":"767278343075290179","title":"Neuronal synapse organization and brain development","description":"The top terms are dominated by neural and synaptic processes (neuroligin clustering in postsynaptic membranes, synaptic vesicle clustering, and brain development), indicating a theme of synapse organization and neural development. Some epithelial differentiation terms are present but do not override the dominant neuronal signal.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072307","count":3},{"id":"GO:0097118","count":3},{"id":"GO:2000809","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0032465","count":2}]},{"hash":"1645419055045538390","title":"DNA replication and cell cycle regulation","description":"The cluster is dominated by GO terms for DNA recombination and DNA-templated replication, with a clear signal for positive regulation of the G1/S transition, indicating a core function in DNA replication and cell cycle control. While other terms touch on stress responses and signaling, the primary theme centers on genome duplication and cell cycle progression.","confidence":"Medium","size":21,"edges":6,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0006261","count":3},{"id":"GO:1900087","count":3},{"id":"GO:0071320","count":3},{"id":"GO:0045454","count":3}]},{"hash":"1194583966820656203","title":"Regulated signaling and adhesion","description":"The top GO terms cluster around modulation of signaling pathways (Notch, integrin-mediated, NF-kappaB), cell motility, and cell-surface interactions (receptor-mediated virion attachment), with links to development (retina vasculature) and immune regulation (dendritic cell activation). This suggests proteins that act as regulators at the cell surface, influencing signaling and adhesion processes across contexts, rather than a single canonical pathway. The connection is present but somewhat broad, hence a moderate confidence in the label.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000145","count":1},{"id":"GO:1901223","count":1},{"id":"GO:2001046","count":1},{"id":"GO:0046813","count":1},{"id":"GO:0043128","count":1}]},{"hash":"55979725628644584","title":"Vertebrate Embryonic Organ Development","description":"The cluster\u2019s top GO terms span development across multiple vertebrate organs (pituitary, midbrain, hindlimb, placenta, heart, eye, gonads, habenula), suggesting a common theme of embryonic organogenesis rather than a single pathway. The presence of a general transcription regulation term complements this as a broad regulatory layer active during development.","confidence":"Medium","size":21,"edges":8,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0021983","count":8},{"id":"GO:0030901","count":7},{"id":"GO:0035116","count":6},{"id":"GO:0001890","count":6}]},{"hash":"1621790112882081590","title":"Unknown","description":"There are no GO terms provided for this cluster, so I cannot infer a coherent shared function. The network is moderately dense (35 edges, 35 triangles) with up to 11 connections per node, and many proteins were re-added by ReCIPE, but without functional terms there is no basis to assign a specific biological theme.","confidence":"","size":21,"edges":35,"triangles":35,"max_degree":11,"top_function":null,"top_go_terms":[]},{"hash":"1362582668489476919","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":3},{"id":"GO:0000395","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0000381","count":2}]},{"hash":"938867628136937332","title":"TLR signaling and innate immune activation","description":"The GO terms point to toll-like receptor pathways (TLR10, TLR13, TRAM-dependent TLR4 signaling), detection of lipopolysaccharide, and defense responses to bacteria, plus regulation of dendritic cell cytokine production and JNK cascade activity. This combination strongly suggests a module focused on innate immune recognition and signaling via TLRs, leading to inflammatory and dendritic cell\u2013mediated responses. Confidence is high that the label captures the cluster\u2019s primary function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034178","count":1},{"id":"GO:0032497","count":1},{"id":"GO:0010572","count":1},{"id":"GO:0002730","count":1},{"id":"GO:0046330","count":1}]},{"hash":"92560221401563310","title":"Embryonic development and organ morphogenesis","description":"This cluster is strongly enriched for developmental and morphogenesis terms, including somite formation, left-right axis specification, trigeminal ganglion development, metanephric kidney development, coronary artery morphogenesis, and axon guidance. A few terms related to immune activation appear but do not override the dominant developmental signal, suggesting these proteins collectively participate in embryonic patterning and organ formation.","confidence":"High","size":21,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":14},{"id":"GO:0050901","count":13},{"id":"GO:0072218","count":13},{"id":"GO:0010572","count":10},{"id":"GO:0001757","count":9}]},{"hash":"490091707092371292","title":"GPCR Signaling and Transcription Regulation","description":"The top GO terms revolve around GPCR signaling (adenylate cyclase-activating adrenergic receptor signaling, adenosine receptor signaling) and receptor guanylyl cyclase signaling, coupled with intracellular signal transduction and regulation of DNA-templated transcription. The presence of hypoxia detection and cellular response to forskolin further supports a theme of GPCR-driven cAMP/cGMP signaling leading to transcriptional regulation.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071880","count":9},{"id":"GO:0001973","count":9},{"id":"GO:0006351","count":8},{"id":"GO:0006355","count":8},{"id":"GO:0030828","count":8}]},{"hash":"697148031089678884","title":"GPCR-ERK Signaling and Sensory/Behavioral Responses","description":"This cluster centers on signaling pathways, especially adenylate cyclase-activating GPCR signaling and the ERK1/2 cascade, and ties to sensory and behavioral outputs (pain perception, visual learning, cocaine-related behavior). Prostaglandin signaling and membrane potential regulation further support a theme of signal transduction influencing neural and behavioral phenotypes, with additional links to immune and cardiac development terms. Confidence is Medium.","confidence":"Medium","size":21,"edges":31,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":9},{"id":"GO:0008542","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0010759","count":9},{"id":"GO:0010579","count":9}]},{"hash":"1740661824216240502","title":"Axon fasciculation and neural development","description":"The top GO terms cluster around axonal fasciculation, paranode localization of axons, and trigeminal nerve development, with supporting roles from BMP signaling in neural development and broader multicellular development. Although immune-related terms appear, the dominant theme is neural development and axon organization, especially in cranial nerve pathways. This makes \"Axon fasciculation and neural development\" a concise and representative label.","confidence":"High","size":21,"edges":43,"triangles":8,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":5},{"id":"GO:0030513","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0002175","count":3}]},{"hash":"1798240555840459885","title":"Neurodevelopmental Signaling and Cell Cycle Control","description":"The top GO terms center on neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration) alongside cell cycle processes (G2/M transition, mitotic cell cycle, negative regulation of proliferation) and include broader signaling pathways (insulin receptor, T cell receptor signaling). This suggests proteins involved in developmental signaling that coordinate growth and differentiation with cell-cycle regulation, making the neurodevelopmental signaling with cell cycle control a coherent label. ","confidence":"Medium","size":21,"edges":61,"triangles":87,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021697","count":14},{"id":"GO:0048679","count":14},{"id":"GO:0060020","count":14},{"id":"GO:0050852","count":14},{"id":"GO:2001275","count":14}]},{"hash":"1036579895286670344","title":"Nucleotide salvage and catabolic metabolism","description":"The cluster shows strong signals for nucleotide salvage and catabolic processes (UMP salvage, nicotinate nucleotide salvage, nucleotide catabolic process, guanosine catabolic process), suggesting a cohesive nucleotide metabolism theme. Immune-related terms (interleukin-2 production, T cell differentiation) and platelet maturation appear sparsely and may reflect broader or multifunctional annotations, but they are less central to the core pattern. ","confidence":"Medium","size":21,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0036345","count":1},{"id":"GO:0009166","count":1},{"id":"GO:0046115","count":1},{"id":"GO:0046638","count":1},{"id":"GO:0034418","count":1}]},{"hash":"1480262562828527941","title":"DNA integration and transposition machinery","description":"The top GO terms are dominated by DNA integration, proviral latency, and transposition, paired with DNA replication and recombination, pointing to enzymes that mobilize and integrate genetic material and coordinate cell-cycle events. A couple terms also touch host entry and infection structure, which can accompany intracellular-mobile-element biology. Overall, the cluster most clearly reflects DNA mobility and genome integration.","confidence":"High","size":21,"edges":15,"triangles":4,"max_degree":8,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0075713","count":7},{"id":"GO:0046718","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0007059","count":5}]},{"hash":"835166658108058518","title":"Neurotransmitter uptake and glycine/monoamine signaling","description":"This cluster\u2019s GO terms are dominated by neurotransmitter transport and metabolism, especially glycine import/secretion and uptake of glycine, serotonin, and dopamine, along with innervation and glial growth aspects. DNA integration and defense response to virus appear as minor outliers and do not define the main theme. The label reflects the central function: neurotransmitter uptake and glycine/monoamine signaling in nervous system activity.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060384","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0051607","count":2},{"id":"GO:1903346","count":1},{"id":"GO:0061537","count":1}]},{"hash":"2013472424821191988","title":"Inflammation signaling and miRNA regulation","description":"The cluster\u2019s top GO terms highlight inflammatory signaling pathways (NF-kappaB, IL-17, TNF) and host defense, alongside RNA regulatory processes (miRNA metabolism and miRNA-mediated gene silencing). This suggests proteins involved in immune signaling with associated RNA regulatory roles, rather than a single tight complex. The label reflects the dominant theme of immune/inflammatory signaling coupled with miRNA regulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":7},{"id":"GO:0072089","count":5},{"id":"GO:0010586","count":5},{"id":"GO:1903883","count":5},{"id":"GO:0001519","count":5}]},{"hash":"1519706701364302047","title":"Retroviral DNA integration and latency","description":"We observe strong representation of DNA recombination, DNA integration, RNA-templated DNA biosynthetic process, and establishment of proviral latency, which together map to retroviral life cycle steps (reverse transcription, genome integration, and latency). The presence of symbiont entry into host cell aligns with intracellular infection, but the core theme is proviral integration and latency. DNA replication and redox-related terms may reflect host\u2013virus interaction contexts but do not override the viral-centric signal.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0046718","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0006260","count":3}]},{"hash":"714100494139699662","title":"Leukocyte Activation and Complement Pathways","description":"Top GO terms show strong enrichment for innate immune processes: complement activation via the lectin pathway, phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and modulation of NK cell chemotaxis. These together point to a cluster centered on leukocyte activation and recruitment during innate immune responses. Developmental terms for metanephric tubule morphogenesis, mesonephric duct development, and cartilage condensation appear as secondary associations and may reflect shared signaling or tissue contexts, but the dominant theme is immune activation and leukocyte interactions.","confidence":"Medium","size":21,"edges":71,"triangles":69,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":19},{"id":"GO:0001502","count":17},{"id":"GO:0006910","count":17},{"id":"GO:0010572","count":17},{"id":"GO:0045575","count":17}]},{"hash":"1498064592165210937","title":"Cross-tissue development and cell adhesion","description":"This cluster\u2019s top GO terms span neural development, cardiac cell adhesion, oocyte/germline localization, and paranodal junction assembly, with additional mentions of cytoskeletal localization and pseudopodium assembly. The common thread is broad developmental roles across multiple tissues rather than a single, cohesive function, suggesting a general involvement in developmental processes and cell\u2013cell/cytoskeletal organization across different tissues.","confidence":"Low","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":2},{"id":"GO:0048364","count":1},{"id":"GO:0006275","count":1},{"id":"GO:0001840","count":1},{"id":"GO:0060188","count":1}]},{"hash":"884190041750431510","title":"Immune Signaling Inhibitors and Vascular Regulation","description":"These proteins cluster around the theme of dampening inflammatory signaling and stabilizing vascular function, as evidenced by GO terms for negative regulation of IL-2 signaling, TLR9 signaling, and the p38 MAPK cascade, plus negative regulation of receptor-mediated pathways (PDGFR-beta) and vascular permeability. Additional terms related to responses to muramyl dipeptide and integrin-mediated adhesion support a broader immune-vascular regulatory role. Some terms (vestibular receptor morphogenesis, obsolete oxidation-reduction process) seem less directly related and may reflect annotation noise, but the core pattern points to immune signaling inhibition with vascular permeability control.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0043116","count":3},{"id":"GO:1902206","count":2},{"id":"GO:2000646","count":2},{"id":"GO:0060116","count":2}]},{"hash":"1927442642131891892","title":"Immune Activation and Leukocyte Migration","description":"This cluster is enriched for GO terms related to innate immune responses and leukocyte trafficking (e.g., response to fungal molecules, phagocytosis recognition, basophil activation, leukocyte tethering/rolling, arachidonate signaling), with a few tissue development terms that may reflect shared signaling pathways. The dominant theme is immune activation and recruitment of immune cells.","confidence":"Medium","size":21,"edges":206,"triangles":1257,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":21},{"id":"GO:0071226","count":21},{"id":"GO:0006910","count":20},{"id":"GO:0010572","count":20},{"id":"GO:0045575","count":20}]},{"hash":"441061325368848154","title":"Cardiovascular GPCR\u2013cAMP and calcium signaling","description":"This cluster centers on GPCR signaling that activates adenylate cyclase (cAMP production) and mobilizes intracellular calcium, with additional themes of prostaglandin response, blood pressure regulation, coagulation, and inflammatory regulation (IL-1\u03b2). While most terms indicate vascular signaling and smooth muscle/cardiac function, a few terms like electron transport chain may reflect general cellular energy demands. Overall, the proteins seem linked to vascular GPCR signaling and downstream Ca2+/cAMP pathways with inflammatory and coagulation associations.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0007190","count":21},{"id":"GO:0045777","count":21},{"id":"GO:0032651","count":20}]},{"hash":"283120906359245709","title":"Cardiovascular GPCR-cAMP signaling and inflammation","description":"The cluster is dominated by GO terms for GPCR-activated adenylate cyclase signaling, calcium mobilization, prostaglandin response, and regulation of vascular tone and cardiac smooth muscle differentiation, along with inflammatory (IL-1\u03b2) and coagulation processes, indicating a cohesive cardiovascular signaling and inflammatory regulation theme. An electron transport chain term may reflect energy requirements of these processes, but the core pattern centers on vascular signaling and inflammation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0045777","count":16},{"id":"GO:0035025","count":15},{"id":"GO:0007190","count":13}]},{"hash":"142595246199367440","title":"Embryonic organogenesis","description":"The top GO terms point to morphogenesis and development across multiple organs (heart structures like aortic valve and right atrium, pericardium, loop of Henle, inner ear, etc.), with regulatory hints from FGF production and hyaluronan synthesis. This suggests a general theme of embryonic organ formation rather than a single pathway. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0003180","count":7},{"id":"GO:0003344","count":7},{"id":"GO:0072070","count":7}]},{"hash":"814799418931447367","title":"NF-kappaB\u2013driven antiviral innate immunity and autophagy","description":"This cluster is dominated by GO terms for innate immune response, NF-kappaB signaling, and defense against virus, with autophagy also represented, suggesting a cohesive antiviral innate immune module where NF-kappaB controls antiviral gene expression and autophagic processes help restrict viral material. Some terms are outdated or peripheral, but the core theme remains clear.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":9},{"id":"GO:0045087","count":8},{"id":"GO:0043123","count":8},{"id":"GO:0051607","count":7},{"id":"GO:0006914","count":6}]},{"hash":"1733493893522022709","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":14},{"id":"GO:0007014","count":14},{"id":"GO:2000637","count":14},{"id":"GO:0061158","count":14},{"id":"GO:0051607","count":13}]},{"hash":"1477155314696859101","title":"Receptor signaling and angiogenesis regulation","description":"This cluster centers on cell-surface receptor signaling, including receptor clustering and internalization, with angiogenesis-related terms (angiogenesis and its regulation) and ECM-associated processes (collagen fibril organization). Additional topics such as guanylyl cyclase signaling and some neural-related terms suggest a broader theme of receptors integrating ECM cues and signaling pathways that modulate vessel formation, with some neural signaling components. Overall, the common thread is receptor-mediated signaling linked to angiogenesis and extracellular matrix interactions.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0007168","count":2},{"id":"GO:0060292","count":2}]},{"hash":"1932226555121787804","title":"Transcription and Translation Regulation","description":"The top GO terms center on DNA-templated transcription, transcriptional regulation by RNA polymerase II, and translation initiation/reinitiation, suggesting the cluster groups proteins involved in gene expression control at both transcriptional and translational levels. Some tissue-development terms may reflect annotation breadth or context-specific roles rather than a core shared function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0072520","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0033137","count":2},{"id":"GO:0033689","count":2}]},{"hash":"2114050096998615542","title":"Autophagy- and ubiquitin-mediated host defense","description":"The cluster centers on autophagy (GO:0006914) and ubiquitin-dependent protein catabolic processes (GO:0042787), with several entries related to antiviral and antibacterial defense (suppression of viral release, negative regulation of intracellular transport of viral material, regulation of LPS signaling). Additional terms on actin ubiquitination and protein localization to microtubules suggest cytoskeletal- and trafficking-informed quality control that supports immune responses. Collectively, these terms point to a cohesive theme of host defense mediated by autophagy and ubiquitin pathways, making the label representative and specific.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033280","count":7},{"id":"GO:0042787","count":7},{"id":"GO:0006914","count":6},{"id":"GO:1901253","count":6},{"id":"GO:0051092","count":6}]},{"hash":"486020976242568791","title":"Cytoskeletal remodeling and EMT signaling","description":"The top GO terms cluster around cytoskeletal structures (terminal web, actomyosin contractile ring, actin filament organization), processes of epithelial to mesenchymal transition, and related signaling (Wnt/calcium). There are also terms related to receptor recycling and development (nephron collecting duct), suggesting roles in developmental morphogenesis driven by cytoskeletal dynamics and endocytic trafficking. Despite some obsolete terms, the core theme points to cytoskeletal remodeling linked with EMT and developmental signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902896","count":3},{"id":"GO:0001921","count":3},{"id":"GO:0001837","count":2},{"id":"GO:0007223","count":2},{"id":"GO:1901841","count":2}]},{"hash":"2288040479380604802","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043123","count":10},{"id":"GO:1902187","count":9},{"id":"GO:0007014","count":9},{"id":"GO:2000637","count":9},{"id":"GO:0061158","count":9}]},{"hash":"903981604025516190","title":"Neuronal adhesion and paranode organization","description":"The cluster is dominated by GO terms for cell adhesion (homophilic/heterophilic and general adhesion) and neuron/axon-related organization (clustering of voltage-gated sodium channels; paranode localization; trigeminal nerve sensory development), indicating a shared function in neuronal cell-cell interactions and axon architecture. Some complement-related terms appear, but the clearest common theme is neural adhesion and paranodal/axonal organization.","confidence":"Medium","size":20,"edges":4,"triangles":1,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0006958","count":3}]},{"hash":"359716688115402467","title":"Developmental signaling and intracellular transport","description":"The top GO terms cluster around developmental signaling pathways (nervous system development; Roundabout signaling; negative regulation of migration in sprouting angiogenesis; ossification) together with intracellular transport and localization processes (melanosome transport; endosome to melanosome transport; stress fiber assembly; protein-containing complex localization). This suggests a theme where signaling cues guide development while coordinating vesicle/ cytoskeletal trafficking, rather than a single narrow function. Some terms like T cell receptor signaling are broader, but the overall pattern supports developmental signaling linked to intracellular transport.","confidence":"Medium","size":20,"edges":13,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090051","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0051496","count":9},{"id":"GO:0034629","count":9},{"id":"GO:0035646","count":9}]},{"hash":"2244349429538361691","title":"Chitin and peptidoglycan cell wall remodeling","description":"The GO terms point to both peptidoglycan and chitin metabolism (biosynthesis and catabolism), cell wall macromolecule turnover, and cellular responses to chitin, suggesting a common theme of cell wall remodeling and chitin signaling. Sporulation and membrane-related terms appear as ancillary context but do not override the core cell-wall focus. Overall, the cluster seems centered on processes that modify or respond to cell wall components.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046854","count":2},{"id":"GO:0021510","count":2},{"id":"GO:1902083","count":2},{"id":"GO:0009252","count":2},{"id":"GO:0009253","count":2}]},{"hash":"1085709142393560821","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032259","count":3},{"id":"GO:0036265","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0009820","count":2},{"id":"GO:0010252","count":2}]},{"hash":"527258788800736085","title":"Nutrient and ion membrane transport","description":"The top GO terms are dominated by transmembrane transport of various nutrients and ions (glucose, myo-inositol, pantothenate, biotin, sodium ions), suggesting the proteins function primarily in membrane transport rather than a single biosynthetic pathway. Some terms like lamellipodium assembly and symbiont entry are present but appear less representative of the overall cluster theme. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008292","count":3},{"id":"GO:0071436","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0015798","count":3},{"id":"GO:0015887","count":3}]},{"hash":"1825968749835710309","title":"Developmental transcriptional regulation","description":"The highest-level terms point to RNA polymerase II-driven transcription and DNA-templated transcription, while many other terms describe development across diverse tissues (muscle, lung vasculature, floor plate, retina, habenula, pancreas, somite). This suggests the cluster comprises proteins linked to transcription machinery that coordinate differentiation programs across multiple lineages, not a single tissue pathway. Therefore, the label Developmental transcriptional regulation fits.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0006351","count":9},{"id":"GO:0035914","count":8},{"id":"GO:0060426","count":6},{"id":"GO:0001756","count":6}]},{"hash":"1444415009109822254","title":"Tight junction regulation and actin remodeling","description":"Explanation: Top terms cluster around bicellular tight junction assembly (and its positive regulation), actin filament branching, and small GTPase\u2013driven signaling, with links to EGFR signaling and cell spreading. Together these suggest a functional module governing epithelial junction integrity and cytoskeletal dynamics.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010923","count":9},{"id":"GO:0070830","count":9},{"id":"GO:0045737","count":8},{"id":"GO:1903348","count":8},{"id":"GO:0007173","count":8}]},{"hash":"1773839231389426629","title":"Regulation of translation initiation","description":"The strongest signal in this cluster comes from GO terms related to initiating protein synthesis and its control: regulation of translational initiation, formation of the translation preinitiation complex, translation reinitiation, and IRES-dependent viral initiation/termination-reinitiation. This points to a core function centered on initiation of translation and its regulatory mechanisms, with some development-related terms likely reflecting pleiotropy rather than a primary cluster theme. Overall, the dominant pattern supports a label focused on translational initiation control.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3}]},{"hash":"198933546831960138","title":"Ribosome Biogenesis and Translational Initiation","description":"The dominant GO terms cluster around small-subunit processome assembly, eIF4F complex assembly, and various modes of translational initiation (including IRES-dependent initiation), along with mRNA export and regulation of translational initiation. This points to a cohesive role in ribosome biogenesis and initiation of protein synthesis, with some peripheral signals for mRNA handling and translation regulation.","confidence":"High","size":20,"edges":67,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0034462","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0097010","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0006406","count":2}]},{"hash":"1379034229272473211","title":"Signaling, immune activation, and ECM remodeling","description":"The top terms combine signaling (ERK1/2 cascade regulation) with immune (complement activation) and extracellular matrix (collagen fibril organization) processes, plus varied cellular stress and response pathways (amyloid-beta, TGF-beta, estradiol, nutrient). This suggests a cluster of proteins involved in signaling and stress responses in an immune/ECM context rather than a single cohesive pathway.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0043525","count":3}]},{"hash":"166137691633375906","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071031","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0019876","count":2},{"id":"GO:0033252","count":2},{"id":"GO:0030655","count":2}]},{"hash":"558490441977231770","title":"Neuronal monoaminergic signaling and synaptic transmission","description":"Based on the GO terms, the cluster centers on brain neurotransmission and sensory processing, with emphasis on monoaminergic pathways (dopamine, serotonin, cocaine response), synaptic communication (cholinergic transmission), neuronal excitability (membrane depolarization, potassium transport), and development of sensory pathways (LGN and vestibulocochlear nerve). These together point to a cohesive theme of neuronal signaling and sensory system function.","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":5},{"id":"GO:0007210","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0033603","count":4},{"id":"GO:0001988","count":4}]},{"hash":"623894806301268765","title":"Cardiac calcium/cAMP signaling","description":"This cluster is dominated by GO terms tied to heart development, regulation of cardiac muscle contraction, and calcium- and cAMP-mediated signaling (calcium release into cytosol; activation of adenylate cyclase; protein phosphorylation). Together these indicate signaling pathways that control cardiac function and excitation\u2013contraction coupling. A few terms about visual perception/opsin signaling reflect shared GPCR and cAMP signaling themes, but the core pattern centers on cardiac calcium and cAMP regulation.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0007601","count":9},{"id":"GO:0022400","count":8},{"id":"GO:0008284","count":8},{"id":"GO:0006468","count":8}]},{"hash":"1753987804459605373","title":"GPCR-cAMP Vasomotor Signaling and Metabolic Regulation","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling, activation of adenylate cyclase, vasoconstriction/blood pressure regulation, and related downstream pathways (ERK cascade, platelet activation). This points to a cohesive theme of GPCR-mediated cardiovascular signaling with accompanying metabolic regulation (thermogenesis, energy metabolism), with some broader signals like pain perception and temperature response likely reflecting shared signaling context. ","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0007190","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0030168","count":12}]},{"hash":"1355974830320279082","title":"Unknown","description":"The top GO terms span diverse, unrelated processes (triglyceride metabolism, xenobiotic catabolic pathways, epoxygenase P450 activity, sex differentiation, maternal/parturition processes, and regulatory roles like cell cycle timing and chemotaxis). There is no clear, single biological theme tying these terms together, so a concise, representative label cannot be assigned beyond Unknown.","confidence":"","size":20,"edges":18,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006641","count":14},{"id":"GO:0035865","count":13},{"id":"GO:1900087","count":13},{"id":"GO:0033072","count":13},{"id":"GO:0010760","count":13}]},{"hash":"736651778644849493","title":"Unknown","description":"The Top Terms span autophagy, immune signaling (NF-kappaB, IL-17), miRNA metabolism, ubiquitin-dependent protein turnover, developmental processes (placenta morphogenesis, stem cell proliferation, embryonic development), and even plant hormone signaling (brassinosteroid pathway). This broad mix lacks a single cohesive function or pathway to define a concise label, and several terms are obsolete, making a confident, representative name inappropriate.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0046597","count":4},{"id":"GO:0006914","count":3},{"id":"GO:1900458","count":3},{"id":"GO:0072089","count":3}]},{"hash":"87788139051970131","title":"Inflammation and GPCR-Calcium Signaling","description":"This cluster is dominated by inflammatory and immune-related terms (inflammatory response, regulation of IL-1 beta production, blood coagulation) along with prostaglandin E stimulus and GPCR signaling, plus calcium release into the cytosol. The convergence on GPCR-regulated signaling and calcium flux, together with xenobiotic/diet-induced thermogenesis hints, supports a cohesive inflammatory-immune signaling module with metabolic coupling. ","confidence":"High","size":20,"edges":86,"triangles":165,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0071502","count":9},{"id":"GO:0071380","count":8},{"id":"GO:0006954","count":8}]},{"hash":"1637943493846799217","title":"Vascular Angiogenesis and Blood Vessel Regulation","description":"The cluster centers on GO terms related to vascular development and angiogenesis, including negative regulation of VEGF receptor signaling, sprouting angiogenesis, and blood coagulation, suggesting a core function in vascular remodeling and signaling. While there are outliers related to eye morphogenesis and endocrine signals, the dominant theme ties to vascular growth, stabilization, and coagulation processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0032757","count":4},{"id":"GO:0010875","count":4},{"id":"GO:0030948","count":4},{"id":"GO:2000860","count":3}]},{"hash":"417950558872781346","title":"Unknown","description":"The GO terms span diverse processes (DNA transposition, transcription, deneddylation) and unrelated metabolic/hormone/retina development terms, with no shared function tying the proteins together and no edges connecting them, so there is no coherent cluster-wide theme to name beyond Unknown.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0090305","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000338","count":2},{"id":"GO:0006590","count":1}]},{"hash":"1177595385013459241","title":"Unknown","description":"The GO terms span interferon responses, bone development, endosomal trafficking, insulin-stimulated glucose import, neuromuscular and synaptic functions, and host-microbial interaction. This broad and diverse set lacks a single cohesive theme to define a concise, specific label, so Unknown is the most appropriate designation.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035456","count":3},{"id":"GO:0030282","count":3},{"id":"GO:0099638","count":3},{"id":"GO:0044381","count":3},{"id":"GO:0046597","count":3}]},{"hash":"1604061473576397490","title":"Ubiquitin-dependent TNF signaling and innate immunity","description":"The top GO terms cluster around ubiquitination processes (K63- and K6-linked), ubiquitin-dependent protein catabolic processes, and autoubiquitination, together with innate immune response and regulation of TNF-mediated signaling. This suggests the proteins function in ubiquitin-mediated control of inflammatory signaling and innate immune responses.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903265","count":11},{"id":"GO:0070534","count":11},{"id":"GO:0042787","count":11},{"id":"GO:0051865","count":11},{"id":"GO:0085020","count":10}]},{"hash":"2100010303571750863","title":"Dopaminergic neuron development and dopamine metabolism","description":"These terms strongly converge on dopamine production and degradation in developing neurons: dopamine biosynthetic process and dopamine catabolic process indicate dopamine metabolism; neuron maturation and positive regulation of neuron projection development point to neuronal growth and connectivity; in utero embryonic development suggests early neurodevelopment; cellular response to cAMP aligns with signaling in neurons. While a couple of terms are obsolete or less relevant, the dominant theme is dopaminergic neuron development and dopamine metabolism.","confidence":"High","size":20,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1902114","count":3},{"id":"GO:0071320","count":3},{"id":"GO:0042416","count":3},{"id":"GO:0042551","count":3},{"id":"GO:0001701","count":3}]},{"hash":"2247369702104612821","title":"Integrin signaling in cartilage and skeletal development","description":"This cluster is characterized by GO terms for integrin-mediated signaling and cell-matrix adhesion, together with cartilage development steps (cartilage condensation, chondrocyte differentiation) and skeletal system development. It also includes ERK signaling regulation and processes linked to tissue morphogenesis and vascular remodeling. Overall, the terms point to a cohesive module in which adhesion and ERK-dependent signaling drive cartilage formation and bone development, supporting a label focused on integrin signaling in skeletal morphogenesis.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007229","count":7},{"id":"GO:0043536","count":7},{"id":"GO:0042535","count":7},{"id":"GO:0060716","count":7},{"id":"GO:0070374","count":7}]},{"hash":"289285559745875460","title":"mRNA splicing and translation initiation","description":"This cluster is enriched for GO terms spanning mRNA processing (splicing via spliceosome, export, regulatory ncRNA-mediated gene silencing, processome assembly, polyadenylation) and translation initiation (preinitiation complex formation, initiation factor assembly, translation initiation, and IRES-dependent initiation). The co-occurrence of spliceosome-related processes with translation initiation machinery suggests a cohesive role in mRNA maturation and subsequent translation control, hence the label.","confidence":"High","size":20,"edges":177,"triangles":935,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0006406","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0048026","count":5}]},{"hash":"79507439728463042","title":"Endothelial-immune signaling and coagulation","description":"The cluster centers on vascular-immune interactions: angiogenesis, endothelial cell adhesion and survival, MAPK/ERK signaling, and immune pathways (adaptive response, complement) together with coagulation processes (platelet regulation, fibrin clot formation). This pattern supports a cohesive vascular-immune-coagulation theme rather than isolated functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0001867","count":5}]},{"hash":"1028865389472794158","title":"Immune cell activation and leukocyte trafficking","description":"This cluster is enriched for innate immune and leukocyte-related processes: cellular response to fungal origin, phagocytosis recognition, leukocyte tethering/rolling, basophil and platelet activation, and regulation of NK cell chemotaxis. While there are a couple of developmental terms present, the dominant pattern centers on immune activation and leukocyte movement and signaling.","confidence":"Medium","size":20,"edges":21,"triangles":5,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":14},{"id":"GO:0001502","count":13},{"id":"GO:0006910","count":13},{"id":"GO:0010572","count":13},{"id":"GO:0045575","count":13}]},{"hash":"1992957620856786550","title":"Developmental Regulation and Cell Cycle Control","description":"The cluster shows enrichment for development-related processes (uterus, brain, retina development) alongside cell cycle activities (mitotic cell cycle, cell division, APC-dependent catabolic process) and gene expression steps (transcription, translation initiation/reinitiation, chromatin modification by histone methylation). This suggests proteins involved in coordinating development with cell proliferation and gene-expression regulation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0051567","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1764414836904304045","title":"Calcium signaling in vascular inflammation and coagulation","description":"The cluster's top GO terms point to calcium release (intracellular Ca2+), inflammatory signaling (regulation of IL-1\u03b2 production, prostaglandin response), and vascular processes (blood coagulation, smooth muscle differentiation), suggesting a common theme of calcium-dependent regulation of vascular inflammation and coagulation pathways. Some terms like grooming behavior, phototransduction, and appetite regulation appear less directly related and may reflect broader gene pleiotropy or annotation across tissues, but do not contradict the main theme.","confidence":"Medium","size":20,"edges":56,"triangles":45,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":19},{"id":"GO:0051209","count":19},{"id":"GO:0071380","count":19},{"id":"GO:0007596","count":19},{"id":"GO:2000724","count":19}]},{"hash":"2002543704852438313","title":"Embryonic Organ Morphogenesis","description":"Top GO terms point to broad developmental and morphogenetic processes across multiple tissues (heart, limb, eye, placenta, habenula, gonads, prostate), with DNA-templated transcription indicating core regulatory programs guiding these events. This suggests a unifying theme of embryonic organogenesis and transcriptional control, making the label representative of the cluster.","confidence":"High","size":20,"edges":118,"triangles":288,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":7},{"id":"GO:0021986","count":7},{"id":"GO:0035116","count":6},{"id":"GO:0001890","count":6},{"id":"GO:0007507","count":6}]},{"hash":"811107467532756999","title":"Muscle and neural development and organization","description":"The top GO terms emphasize muscle-related processes (sarcomere organization, positive regulation of myoblast differentiation) along with neural development and structural organization (paranodal junction assembly, trigeminal nerve organization, ROBO, SHH, and BMP signaling, plus cell adhesion). This points to a cohesive theme of tissue patterning and development in muscle and nerve systems. Some terms appear less related (symbiont entry into host cell, obsolete redox), likely annotation noise, but do not change the overall interpretation.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0045663","count":2}]},{"hash":"1125211132878317811","title":"Hypoxia-related angiogenesis and cell cycle signaling","description":"The top GO terms show a focus on hypoxia response, angiogenesis-related branching in blood vessel morphogenesis, multicellular development, and signaling pathways involving kinase activity and GTPases, along with cell cycle processes. This pattern points to proteins coordinating vascular development and cell proliferation under low-oxygen conditions, despite a few outlier terms. Confidence: Medium","confidence":"","size":20,"edges":42,"triangles":7,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000742","count":7},{"id":"GO:0071456","count":6},{"id":"GO:0031954","count":6},{"id":"GO:0051028","count":5},{"id":"GO:0000278","count":5}]},{"hash":"8925206421861837","title":"Ubiquitin-Proteasome\u2013Mediated Protein Degradation","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes (ERAD, SCF-proteasomal degradation, K48/K63-linked ubiquitination, general ubiquitin-dependent degradation). These indicate a core function in tagging and degrading proteins. Additional terms related to transcription regulation and development suggest these proteolytic processes modulate gene expression and growth signals. Overall, the cluster centers on ubiquitin-proteasome\u2013mediated protein turnover and its regulatory links to transcription and development.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0001403","count":3}]},{"hash":"1312504388501795308","title":"Neural development and innate immune signaling","description":"Top GO terms largely indicate neural development (myelination, axonal fasciculation, synapse assembly, nerve impulse) and, separately, innate immune responses (LPS sensing). Because there are no interactions between proteins, the link is not strictly cohesive, but neural development is the dominant theme; the name emphasizes this primary function while noting possible immune annotations.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0014068","count":3}]},{"hash":"741243633829455688","title":"Plant mitosis and spindle assembly","description":"The dominant signals are mitosis-related (chromosome alignment, spindle assembly, cell division) and microtubule/cytoskeleton activities, with plant-specific processes (chloroplast movement, root development) and vesicle trafficking, suggesting a cluster centered on plant mitotic machinery and cytoskeleton dynamics.","confidence":"High","size":20,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048364","count":7},{"id":"GO:0035617","count":7},{"id":"GO:0007080","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0051301","count":5}]},{"hash":"1111992798038988791","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around nervous system development (axon guidance, retina and Schwann cell development, neuronal-glial interactions) and synaptic/cholinergic signaling (G protein-coupled acetylcholine receptor signaling, receptor clustering, synaptic transmission). This suggests a coherent module focused on neural patterning and neurotransmission, with a few non-neural terms likely reflecting shared developmental pathways or annotation breadth.","confidence":"High","size":20,"edges":186,"triangles":1070,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:1905815","count":6},{"id":"GO:0072249","count":6},{"id":"GO:0043113","count":6},{"id":"GO:0032224","count":6},{"id":"GO:0014044","count":6}]},{"hash":"2085625025850898208","title":"Embryonic Development and Lineage Differentiation","description":"The terms cluster around developmental and differentiation processes across tissues (in utero embryonic development, neuron maturation, granulocyte and erythrocyte differentiation, pituitary gland development), suggesting a theme of lineage specification and organ development. Some immune and metabolic terms appear as outliers, but the dominant pattern is developmental differentiation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":9},{"id":"GO:0042551","count":8},{"id":"GO:0043046","count":8},{"id":"GO:0030851","count":8},{"id":"GO:0045648","count":8}]},{"hash":"1334851736494651351","title":"Embryogenesis and Angiogenesis Regulators","description":"The top GO terms cluster around embryonic development, axis patterning, and both positive and negative regulation of growth and angiogenesis, including IGF, TGF-beta, and NO signaling, plus nerve growth factor production. This suggests a cohesive role in developmental signaling and vascular formation during early development.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043569","count":3},{"id":"GO:0001701","count":2},{"id":"GO:0010751","count":2},{"id":"GO:0032902","count":2},{"id":"GO:0016525","count":2}]},{"hash":"1560940287202182424","title":"Steroid Hormone Biosynthesis and Metabolism","description":"The top GO terms are dominated by steroid hormone biosynthesis and catabolic/metabolic processes (estrogen, testosterone, glucocorticoids, C21-steroid metabolism), with a related lipid biosynthesis term and a connection to lung development via glucocorticoids. This suggests a cohesive functional theme around production and breakdown of steroid hormones, making this a concise, representative label for the cluster.","confidence":"High","size":20,"edges":108,"triangles":156,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0006355","count":7},{"id":"GO:0030324","count":7},{"id":"GO:0008207","count":6},{"id":"GO:0006703","count":6}]},{"hash":"1020134238827440598","title":"Leukocyte activation and inflammation","description":"The top GO terms are dominated by immune-related processes: basophil activation, leukocyte tethering/rolling, phagocytosis recognition, cellular response to fungal molecules, and regulation of NK cell chemotaxis, together with inflammatory signaling such as arachidonate secretion and platelet activation. Although developmental terms appear (cartilage condensation, mesonephric duct/morphogenesis), the prevalent pattern points to immune cell activation and inflammatory responses, justifying this label.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":20},{"id":"GO:0006910","count":20},{"id":"GO:0010572","count":20},{"id":"GO:0045575","count":20},{"id":"GO:0050901","count":20}]},{"hash":"1344076135705389896","title":"Cell wall and capsule polysaccharide biosynthesis","description":"The top GO terms cluster around cell wall and capsule/envelope biosynthesis (capsule polysaccharide, cell wall polysaccharide, mycolate layer, chitin) with UDP-D-galactose metabolism supporting polymer formation, suggesting a shared function in envelope assembly across species. A few terms pertain to unrelated processes (developmental and mRNA tail processing), but the dominant theme is polysaccharide and cell wall biosynthesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0045227","count":3},{"id":"GO:0070592","count":3},{"id":"GO:0071769","count":3},{"id":"GO:0052573","count":3}]},{"hash":"245633272761368419","title":"Unknown","description":"The top GO terms span both neural development (embryonic development, Purkinje cell layer development, synapse maturation) and immune complement activation (classical, alternative, lectin pathways, and membrane attack complex), with additional unrelated terms like fertilization. There is no single cohesive function tying these terms together, suggesting the cluster represents diverse, non-overlapping processes rather than a specific shared function.","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0006957","count":2},{"id":"GO:0090528","count":2},{"id":"GO:0034392","count":2},{"id":"GO:0021680","count":2}]},{"hash":"244422885313992004","title":"Neuronal signaling and autonomic regulation","description":"This cluster centers on neural communication and autonomic control, with frequent terms for neurotransmitter signaling (serotonin, dopamine, cholinergic transmission), membrane depolarization, and regulation of heart rate and respiration. Developmental terms for sensory nerves (LGN and vestibulocochlear) also point to broader nervous system function, supporting a cohesive neurophysiological theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002087","count":20},{"id":"GO:0007210","count":19},{"id":"GO:0071805","count":19},{"id":"GO:0033603","count":19},{"id":"GO:0001988","count":19}]},{"hash":"2097133491753474767","title":"Unknown","description":"The terms span very diverse biological areas: cellular response to potassium ions, mitotic cell cycle regulation, antibiotic biosynthesis, immune cell chemotaxis, xenobiotic metabolism, P450 epoxygenase pathways, sex differentiation and maternal/parturition processes, and organofluorine metabolism. This lack of a single cohesive function or pathway among the proteins suggests no unified theme. Therefore the cluster is best labeled Unknown with no confidence in a representative function.","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035865","count":16},{"id":"GO:1900087","count":16},{"id":"GO:0033072","count":16},{"id":"GO:0010760","count":16},{"id":"GO:0042738","count":16}]},{"hash":"1552391576828159244","title":"Neural axon guidance and vascular morphogenesis","description":"These proteins cluster around two related themes: axon guidance and nerve development (negative regulation of axon extension, facial/trigeminal nerve organization, sympathetic neuron guidance) and vascular morphogenesis/angiogenesis (coronary/artery morphogenesis, VEGF/neuropilin signaling). The overlap suggests a shared role in guidance cues that shape both neural and vascular patterning, with receptor signaling (e.g., HGF receptor) supporting these pathways. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0048843","count":4},{"id":"GO:0048012","count":4},{"id":"GO:1902378","count":4},{"id":"GO:0021612","count":4},{"id":"GO:0061441","count":4}]},{"hash":"2033013411645238429","title":"NF-kappaB\u2013mediated innate immunity and autophagy","description":"The top GO terms show innate immune response, positive regulation of canonical NF-kappaB signaling, and autophagy, indicating a cluster of proteins involved in NF-kappaB\u2013driven immune signaling with autophagy regulation. While some plant- or obsolete-annotation terms appear, the dominant theme centers on NF-kappaB\u2013associated immune responses and autophagic processes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0006914","count":4},{"id":"GO:1900458","count":4}]},{"hash":"1115144911528693878","title":"Immune signaling and inflammatory regulation","description":"The Top Terms are dominated by immune/inflammatory pathways: positive regulation of TNF-mediated signaling, NF-kappaB activity, dendritic cell differentiation, chemokine production, and xenobiotic response, with additional terms on actin ubiquitination and miRNA-mediated gene silencing, suggesting regulation of immune signaling and inflammatory responses. The myelination term appears as a minor aspect and does not define the cluster; overall, the proteins appear to cluster around immune modulation and inflammatory signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0007014","count":2}]},{"hash":"597744748939959328","title":"Retina and phototransduction signaling cluster","description":"The top GO terms center on visual system processes\u2014phototransduction, visual perception, and retina development\u2014indicating these proteins are mainly involved in retina biology and light-vision signaling. Other terms like ERK and GTPase regulation may reflect broader signaling roles, but the dominant theme is retina/phototransduction. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035774","count":6},{"id":"GO:0007602","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0022400","count":6},{"id":"GO:0043547","count":6}]},{"hash":"1533183022238298577","title":"Unknown","description":"Top terms span ion transport, signaling, transcription, apoptosis, and miscellaneous localization and drug-response terms, with no single dominant process evident; thus a cohesive, specific label cannot be assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0019226","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0097271","count":1}]},{"hash":"1516540498412504078","title":"Cell signaling and motility cluster","description":"The top GO terms are dominated by intracellular signal transduction, cell migration, and cell-matrix adhesion, signaling pathways and interactions that govern movement and tissue remodeling. Additional terms like fat cell differentiation and response to muscle stretch fit into broader contexts of developmental and mechanical signaling. Some outliers (mRNA processing, telomere maintenance) are present but do not define the cluster\u2019s core function. Overall, these proteins seem linked by signaling roles related to cellular movement and adhesion.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006397","count":5},{"id":"GO:0035556","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0045444","count":4},{"id":"GO:0035994","count":4}]},{"hash":"212876219718557879","title":"Cell Signaling and Calcium Dynamics","description":"The top GO terms point to a broad signaling theme: Wnt signaling, GPCR-related signaling, endocytosis regulation (pinocytosis), and calcium release into cytosol, along with responses to mechanical stimuli, vitamin D, and pain, plus even cardiac-related action potential regulation. There isn\u2019t a single cohesive pathway driving all members; instead, the cluster seems enriched for general signaling and calcium-response functions across diverse contexts, justifying a high-level label rather than a single specific process.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048549","count":7},{"id":"GO:0016055","count":6},{"id":"GO:0071260","count":6},{"id":"GO:0033280","count":6},{"id":"GO:0048265","count":6}]},{"hash":"79276624579948362","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":10},{"id":"GO:2000637","count":10},{"id":"GO:0061158","count":10},{"id":"GO:1902187","count":10},{"id":"GO:0018032","count":9}]},{"hash":"1620660676904106217","title":"Ubiquitin-Dependent Antiviral Proteolysis","description":"The cluster is strongly enriched for ubiquitin-dependent protein catabolic process, with additional signals of antiviral readiness such as cellular response to exogenous dsRNA and defense response to virus by host, suggesting a core function in ubiquitin-mediated protein turnover tied to antiviral signaling. Other terms like eye development or mitochondrial fission may reflect broader regulatory roles or annotation bias, but the dominant theme centers on ubiquitin-mediated proteolysis in immune contexts.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0071360","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0043010","count":5},{"id":"GO:0032464","count":5}]},{"hash":"111217596240797578","title":"Fat Cell Differentiation and Calcium Signaling","description":"The top GO terms include fat cell differentiation and calcium ion release into the cytosol, along with lipid catabolism, protein modification and turnover, and endocytosis, suggesting a theme of adipocyte differentiation linked to calcium-dependent signaling and membrane/lipid remodeling. While the terms are diverse, the prominence of fat cell differentiation and calcium signaling provides a cohesive, interpretable label for this cluster.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0046475","count":2},{"id":"GO:0035508","count":2},{"id":"GO:0070212","count":2}]},{"hash":"638716744083991212","title":"Centromere-Kinetochore Assembly and Mitosis","description":"The GO terms are dominated by centromere/kinetochore-related processes (CENP-A chromatin assembly, kinetochore localization) and mitotic activities (cell division, microtubule severing), pointing to chromosome segregation machinery. Minor signals for RNA processing exist but do not override the mitotic theme.","confidence":"High","size":19,"edges":9,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0006406","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0034501","count":4}]},{"hash":"1664273400893454531","title":"Cytoskeletal signaling and cell adhesion","description":"The cluster centers on cytoskeletal-related processes (microtubule anchoring) and signaling cascades that link adhesion and intracellular responses (integrin signaling, GTPase regulation, phosphorylation). The presence of heart development/contraction terms and immune signaling (T cell/B cell pathways) suggests broadly connected signaling and cytoskeletal dynamics rather than a single specialized function, justifying a label around cytoskeletal signaling and cell adhesion.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034453","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1902750676965724039","title":"Cardiac development and actin cytoskeleton remodeling","description":"The cluster shows strong signals for heart development and cardiac muscle contraction, along with lamellipodium assembly and actin cytoskeleton reorganization, pointing to roles in cardiac tissue formation and cytoskeletal dynamics. Additional terms like cell migration, polarity establishment, and protein ubiquitination suggest regulatory processes coordinating movement and structure in cardiac cells.","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0033138","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0048549","count":4}]},{"hash":"1165312092837522176","title":"Unknown","description":"The GO terms show a broad mix: neural/nerve development (myelination), enamel formation (amelogenesis), tissue identity maintenance, centrosome localization, protein complex assembly, antiviral/innate immunity, cell cycle regulation, Rho signaling, and GPCR/thrombin signaling. No single cohesive function or pathway ties these together, so a meaningful, specific cluster label is not evident. Confidence: None","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0097186","count":2},{"id":"GO:0048496","count":2},{"id":"GO:0051661","count":2},{"id":"GO:0051291","count":2}]},{"hash":"628036038855951208","title":"Neuronal signaling and ion-channel transport","description":"This cluster centers on ion channels and membrane excitability (potassium, sodium, calcium transport; depolarization; excitatory postsynaptic potentials) and neurochemical signaling (serotonin and dopamine pathways), linking neural activity to startle responses and circadian sleep regulation, with a note of neuromuscular growth. Together these terms point to a coherent role in neural signaling and synaptic/neuromuscular communication.","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":12},{"id":"GO:0051899","count":11},{"id":"GO:0001964","count":11},{"id":"GO:0035725","count":11},{"id":"GO:0098703","count":11}]},{"hash":"2037866041696481879","title":"Transmembrane Solute Transporters","description":"Top GO terms all point to transmembrane transport across membranes, covering ions (K+, Na+), nitrates/nitrite, and diverse sugars/substrates. This pattern indicates a cluster of diverse solute transporters rather than a single catalytic activity.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055085","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0015757","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0015707","count":2}]},{"hash":"1372373783943616909","title":"Neural development and synapse formation","description":"This cluster is driven by neural-development terms: peripheral nervous system development, neuron migration, and positive regulation of synapse assembly, with supporting adhesion-related terms. While a couple of terms touch on unrelated processes, the dominant theme is neural development and synaptogenesis, suggesting these proteins cooperate in establishing neural circuits. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007422","count":2},{"id":"GO:1900747","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0051965","count":2}]},{"hash":"937726620501661532","title":"Tissue morphogenesis and developmental signaling","description":"This cluster\u2019s terms converge on developmental processes across tissues (bone ossification, brain development, multicellular growth) and on mechanisms of tissue organization (adherens junctions) plus cytoskeletal dynamics (stress fiber assembly) and signaling (ERK cascade) with regulatory layers such as ubiquitination. Together, these suggest proteins acting in growth, differentiation, and morphogenesis rather than a single specialized function, justifying a label around tissue morphogenesis and developmental signaling.","confidence":"Medium","size":19,"edges":29,"triangles":16,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":5},{"id":"GO:0055091","count":4},{"id":"GO:0034332","count":4},{"id":"GO:0051496","count":4},{"id":"GO:0016567","count":4}]},{"hash":"2146468943703021974","title":"Unknown","description":"The GO terms are diverse, including nervous system development (brain development, GABAergic synaptic transmission), cardiac regulation of ventricular action potential, and non-neural processes like ossification and keratinization. There is no single dominant biological function uniting these terms, suggesting the proteins may participate in multiple, tissue-specific processes. Because a cohesive theme cannot be inferred from these terms, I cannot assign a specific, representative label beyond Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086073","count":4},{"id":"GO:0016339","count":4},{"id":"GO:0045176","count":4},{"id":"GO:0098911","count":4},{"id":"GO:0043931","count":4}]},{"hash":"277849546880744423","title":"Neurodevelopment and Axon Guidance","description":"The top GO terms are strongly centered on nervous system development, neurogenesis, axon guidance, synapse assembly, and myelination, with supporting Hedgehog/Robo signaling phrases. While a couple terms touch on non-neural processes, the dominant theme is neural development and neural connectivity formation.","confidence":"High","size":19,"edges":116,"triangles":321,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0045663","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0035385","count":4}]},{"hash":"1677537810965400081","title":"Developmental Morphogenesis Signaling","description":"This cluster shows a pattern dominated by morphogenesis-related processes (pericardium morphogenesis, palatal shelf morphogenesis, epithelial apoptotic process in palatal morphogenesis) and signaling-related regulation (protein tyrosine kinase activity, nitric oxide biosynthesis, synaptic transmission). These suggest a coherent theme around developmental morphogenesis and associated cell signaling, with a few outlier metabolic terms that may reflect annotation noise. ","confidence":"Medium","size":19,"edges":49,"triangles":25,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019491","count":2},{"id":"GO:0061097","count":2},{"id":"GO:0071318","count":2},{"id":"GO:0006564","count":2}]},{"hash":"1184600462834912218","title":"Developmental and Immune Signaling with Mitochondrial Regulation","description":"These proteins show strong signals for developmental processes (multicellular development and eye development) while also highlighting immune defense regulation (positive regulation of defense response to virus, response to dsRNA) and mitochondrial dynamics/apoptosis (mitochondrial fission and outer membrane permeabilization). The combination suggests a theme where developmental signaling interfaces with immune stress responses and mitochondrial-mediated regulation, rather than a single, narrow function.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":11},{"id":"GO:0008284","count":10},{"id":"GO:0043010","count":9},{"id":"GO:0032464","count":9},{"id":"GO:0002230","count":9}]},{"hash":"1625529737354020655","title":"Auditory Synaptic Transmission","description":"This cluster centers on neural signaling linked to sound, as indicated by GO terms for vocalization behavior, sensory perception of sound, and chemical synaptic transmission, plus glutamate secretion. While a few terms relate to barrier formation and cell proliferation, the strongest signals point to auditory signaling and synaptic communication, supporting this label.","confidence":"Medium","size":19,"edges":66,"triangles":67,"max_degree":14,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0071625","count":13},{"id":"GO:0008285","count":10},{"id":"GO:0070433","count":10},{"id":"GO:0090557","count":10},{"id":"GO:0014047","count":9}]},{"hash":"1363639738381699036","title":"Sensory perception and neural development","description":"This cluster is driven by sensory-focused terms (visual perception, sensory perception of pain) and neural development processes (inner ear development, synapse assembly, ERK signaling), indicating a theme of sensory system development and neural communication.","confidence":"","size":19,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007601","count":7},{"id":"GO:0019233","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0051965","count":6}]},{"hash":"1594807916405902433","title":"Embryonic Development and Tissue Morphogenesis","description":"The cluster\u2019s GO terms are dominated by embryogenesis-related processes: cartilage morphogenesis, left-right pattern formation, trophoblast giant cell differentiation, and pancreatic cell development, indicating a role in development and tissue morphogenesis. A few terms (visual perception, dsRNA response, DNA replication) are broader or less specific to morphogenesis, but the strongest signal points to developmental differentiation and patterning.","confidence":"Medium","size":19,"edges":25,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:2001170","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0071360","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1215929462093082180","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":165,"triangles":876,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0006406","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0006656","count":3}]},{"hash":"1579565005671047014","title":"Innate Antiviral Defense and Autophagy","description":"This cluster centers on innate immune response and antiviral defense, with autophagy as a key mechanism (GO:0045087, GO:0006914), plus terms indicating modulation of viral replication and trafficking (GO:1901253, GO:0045869) and related membrane repair. Some outlier terms (e.g., plant- or development-related GO terms) seem incidental to the main antiviral/immune theme, but the core signals point to host defense and autophagy pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":7},{"id":"GO:0001778","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0006914","count":5},{"id":"GO:1900458","count":5}]},{"hash":"1315305216508513591","title":"Neural Development and Synaptic Signaling","description":"The cluster\u2019s top GO terms show a clear emphasis on neural-related processes such as short-term memory, excitatory postsynaptic potential, and retina layer formation, alongside broader signaling activities like protein phosphorylation and GTPase regulation. While there are a few unrelated terms (e.g., abscisic acid signaling, heart development), the strongest and most cohesive signal across the set is neural development and synaptic signaling, justifying a neural-centric label with moderate confidence due to some noise. ","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0006468","count":2}]},{"hash":"899655168508808719","title":"Glycine and monoaminergic neurotransmitter transport","description":"The cluster is dominated by GO terms for glycine import/secretion and glycinergic synaptic transmission, along with dopamine and serotonin uptake and related catabolic/regulatory processes. This suggests a cohesive theme around neurotransmitter transport and signaling at synapses, especially glycinergic and monoaminergic pathways, with some neural support context (perineurial glial growth).","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903346","count":11},{"id":"GO:0061537","count":11},{"id":"GO:0036233","count":11},{"id":"GO:0051610","count":11},{"id":"GO:0042066","count":11}]},{"hash":"1837781239923350951","title":"Angiogenesis and vascular endothelial regulation","description":"GO terms point to blood vessel formation and endothelial dynamics (angiogenesis, endothelial cell migration, vasoconstriction) as well as vascular/immune signaling (platelet activation, complement activation, adaptive immune response). ERK1/2 cascade regulation and negative regulation of cell-substrate adhesion further support a role in endothelial cell signaling and migration, consistent with angiogenic processes during inflammation or thrombotic events.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":10},{"id":"GO:0010572","count":6},{"id":"GO:0071226","count":6},{"id":"GO:0010812","count":5},{"id":"GO:0001525","count":5}]},{"hash":"916117061959010180","title":"Transposon and proviral integration","description":"The cluster is dominated by GO terms related to DNA transposition, DNA integration, and proviral latency establishment, which point to mobile genetic elements (transposons/retroelements) and viral genome integration processes. There are additional signals of host-virus interactions (defense response to virus) and related cellular processes, suggesting a theme around transposon/retroviral activity and viral-host interplay rather than a single housekeeping function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0007059","count":4},{"id":"GO:0006313","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0046718","count":4}]},{"hash":"218238722737982104","title":"Cell cycle, signaling, and endosomal trafficking","description":"The cluster shows strong representation of cell cycle and division terms (mitotic cell cycle, cell division) alongside signaling pathways (positive regulation of JNK cascade, positive regulation of canonical Wnt signaling) and endosomal transport processes (early endosome to late endosome, endosome to lysosome) and ubiquitination, all of which align with coordinated cell proliferation and membrane trafficking during tissue remodeling and wound healing/migration. Confidence: High","confidence":"","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090051","count":10},{"id":"GO:0071260","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0046330","count":9},{"id":"GO:0045022","count":8}]},{"hash":"1625773107959317574","title":"Neural Axon Guidance and Development","description":"The top GO terms are heavily centered on axon guidance across diverse neuron types (retinal ganglion, commissural, branchiomotor, sympathetic, vestibulocochlear) and broader neural development, with additional related morphogenesis terms. This suggests the proteins in this cluster function together in guiding neuronal projections and shaping neural structures during development.","confidence":"High","size":19,"edges":78,"triangles":131,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0060666","count":3},{"id":"GO:0048843","count":3},{"id":"GO:1902336","count":3},{"id":"GO:0071679","count":3},{"id":"GO:0097491","count":3}]},{"hash":"1788961478428974382","title":"Retinoid Metabolism","description":"This cluster is dominated by GO terms for retinal metabolic process and retinol metabolic process (each 18 mentions), indicating a core theme around vitamin A metabolism. While other terms point to diverse metabolic and stress-related processes (oxidative stress response, digestion, urine regulation, sorbitol and glucuronate pathways, prostaglandin response, endothelial apoptosis), the strongest signature is retinoid metabolism. Confidence: Medium","confidence":"","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":18},{"id":"GO:0042572","count":18},{"id":"GO:0071805","count":12},{"id":"GO:0006061","count":12},{"id":"GO:0035809","count":12}]},{"hash":"1932897904807617779","title":"NF-kappaB-mediated Innate Immunity and Autophagy","description":"The top GO terms cluster around innate immune response and NF-kappaB signaling, with several terms for positive regulation of NF-kappaB activity/signaling, plus ubiquitin-related regulation and autophagy. This points to a module where innate immune signaling is modulated by ubiquitin pathways and intersecting autophagy, despite some noise terms from other contexts. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0043123","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0070374","count":3}]},{"hash":"1755656007983558145","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0007014","count":5},{"id":"GO:2000637","count":5},{"id":"GO:0061158","count":5},{"id":"GO:1902187","count":5}]},{"hash":"2143487331962240461","title":"Steroid Hormone Biosynthesis and Lipid Metabolism","description":"This cluster is dominated by GO terms for biosynthesis of steroid hormones (estrogen, testosterone, glucocorticoids) and related lipid biosynthetic pathways (very long-chain fatty acids, sphingolipids, etc.), suggesting a cohesive module of lipid and steroid hormone production. The presence of multiple steroid biosynthesis terms alongside lipid biosynthetic terms supports a unifying function in steroid hormone production and broader lipid metabolism.","confidence":"High","size":19,"edges":62,"triangles":65,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0042619","count":10},{"id":"GO:0008207","count":9},{"id":"GO:0006703","count":9},{"id":"GO:0042761","count":9}]},{"hash":"1287997037679019848","title":"Neural development and axon guidance","description":"This cluster shows enriched terms for pyramidal neuron differentiation, axon guidance, synapse assembly, cell adhesion, and fasciculation, with collagen fibril organization supporting neural wiring. While there are some angiogenesis and complement-related terms at lower frequency, the dominant theme is neural development and axon pathfinding.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021859","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0033564","count":3},{"id":"GO:0051965","count":3}]},{"hash":"943342236864054460","title":"Paranodal Axon Guidance and Assembly","description":"This cluster centers on axon guidance across peripheral neural contexts (sympathetic, branchiomotor, trigeminal projections) and paranodal region features (localization to paranodes, paranodal junction assembly), with supporting semaphorin-plexin signaling; neural crest migration and retina development terms match the broader neural development theme. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":4},{"id":"GO:0071205","count":4},{"id":"GO:0097491","count":4},{"id":"GO:0021785","count":4},{"id":"GO:0030913","count":4}]},{"hash":"965676429100548090","title":"Immune signaling and cytokine production","description":"This cluster centers on innate and adaptive immune signaling, with terms for bacterial detection, cytokine production in immune responses, regulation of dendritic cell cytokine output, and non-canonical NF-kappaB signaling, plus Th17 differentiation. A few outlier terms exist, but the dominant theme is immune response and cytokine regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032515","count":1},{"id":"GO:0007094","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0048833","count":1},{"id":"GO:2000321","count":1}]},{"hash":"51484396409999379","title":"Thermogenesis and vascular GPCR signaling","description":"The top GO terms cluster around temperature-related responses (diet-induced thermogenesis; cellular response to temperature stimulus) together with vascular signaling processes (platelet activation; positive regulation of vasoconstriction) and GPCR/calcium signaling (adenylate cyclase-activating GPCR pathway; calcium release). This points to a cohesive theme of thermoregulatory and cardiovascular signaling, with some ancillary nociception context, rather than a single biosynthetic pathway. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0030206","count":4},{"id":"GO:0015015","count":4}]},{"hash":"308196769677265330","title":"Coagulation and fibrinolysis with complement activation","description":"The cluster is dominated by GO terms for blood coagulation, plasminogen activation, and fibrinolysis, plus complement activation via the lectin pathway, suggesting a core theme of hemostasis and innate immunity. Some terms (transcription regulation, development, fertilization) seem less connected, likely representing noise around a broader protein set. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0042730","count":4}]},{"hash":"1128637331315697128","title":"Cardiovascular development and endothelial differentiation","description":"Many top terms center on heart development (cardiac right atrium morphogenesis, Notch signaling in heart field cardioblast proliferation, venous endothelial cell differentiation). The inclusion of cellular response to mechanical stimulus and microtubule severing also aligns with mechanotransduction and cytoskeletal dynamics important for cardiovascular morphogenesis. While a few terms are peripheral, the dominant theme is cardiovascular development and vascular differentiation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0003213","count":3},{"id":"GO:0060843","count":3},{"id":"GO:0033280","count":3}]},{"hash":"1203634842474202536","title":"Innate Immunity and Chemokine Regulation","description":"The cluster is enriched for innate immune response, complement activation, and chemokine production terms, indicating a common theme of host defense and inflammatory signaling; while other terms are more diverse (symbiont entry, sarcomere organization), the dominant signal ties to innate immunity and chemokine regulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0046718","count":4},{"id":"GO:0045214","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1087550285384904419","title":"Innate antiviral defense and autophagy","description":"This cluster centers on ubiquitin-dependent protein catabolism, innate immune and antiviral defense, and autophagy, with related regulation of apoptosis and viral material transport, suggesting a cohesive set of proteins involved in antiviral innate immunity and autophagic degradation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0051607","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0006914","count":9},{"id":"GO:1901253","count":9}]},{"hash":"306048140899613471","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":9},{"id":"GO:0045087","count":8},{"id":"GO:0007014","count":7},{"id":"GO:2000637","count":7},{"id":"GO:0061158","count":7}]},{"hash":"1139870744935614541","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0002107","count":3},{"id":"GO:0000289","count":3},{"id":"GO:0000467","count":3},{"id":"GO:0010606","count":3}]},{"hash":"2035838224420514314","title":"Autophagy and Epigenetic Regulation","description":"The top term is autophagy, with many entries pointing to regulation of protein turnover and epigenetic programming, including DNA demethylation; while there are related signals in development and immune pathways, autophagy and its epigenetic context appear as the central theme tying the terms together.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":16},{"id":"GO:1900458","count":16},{"id":"GO:2000059","count":16},{"id":"GO:0060669","count":16},{"id":"GO:1901536","count":16}]},{"hash":"1175496860225252001","title":"Cardiac Sarcomere Organization and Contraction","description":"Most of the terms point to cardiac muscle biology\u2014sarcomere organization, regulation of sarcomere assembly, cardiac muscle contraction, and modulation of heart rate\u2014along with some vascular smooth muscle\u2013related processes and myotube development. This suggests the cluster captures components of cardiac muscle structure and function, with a few annotations that may reflect incidental or cross-domain terms (e.g., spicule insertion, motile ciliogenesis).","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048496","count":2},{"id":"GO:0003065","count":1},{"id":"GO:0045214","count":1},{"id":"GO:1904753","count":1},{"id":"GO:0060298","count":1}]},{"hash":"1990274756970691205","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":12},{"id":"GO:0007014","count":12},{"id":"GO:2000637","count":12},{"id":"GO:0061158","count":12},{"id":"GO:0072089","count":10}]},{"hash":"169994824171309117","title":"Negative regulation of signaling and gene expression","description":"This cluster\u2019s top GO terms center on down-regulating multiple processes: negative regulation of IGF receptor and brassinosteroid signaling, autophagy, ubiquitin-dependent protein turnover, epigenetic gene regulation (DNA demethylation, epigenetic programming), and even modulation of viral material transport/replication and NF-kappaB activity. The common thread is suppression or dampening of diverse cellular pathways, rather than activation, suggesting proteins that broadly act to down-regulate signaling and gene expression processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043569","count":4},{"id":"GO:0006914","count":3},{"id":"GO:1900458","count":3},{"id":"GO:2000059","count":3},{"id":"GO:0060669","count":3}]},{"hash":"1162930931012946574","title":"Ubiquitin-Mediated Regulation of Development and Immunity","description":"The top GO terms cluster around ubiquitination and ubiquitin-dependent proteolysis, indicating a core role in protein tagging and turnover. Several terms relate to innate immune responses to viruses and dsRNA, suggesting involvement in antiviral signaling. Development-related terms (eye development, multicellular organism development) imply roles in growth and tissue differentiation. The mix suggests a broader regulatory program in which ubiquitin-mediated processes coordinate development with immune responses and related cellular stress pathways, possibly including mitochondrial dynamics as part of cellular remodeling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":7},{"id":"GO:0033280","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0043010","count":5},{"id":"GO:0032464","count":5}]},{"hash":"1084525153083944716","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":8},{"id":"GO:0018032","count":8},{"id":"GO:2000637","count":8},{"id":"GO:1903886","count":8},{"id":"GO:0072089","count":8}]},{"hash":"570010824311854346","title":"Innate Immune Signaling and Antiviral Defense","description":"The cluster's top GO terms cluster around innate immunity and NF-kappaB signaling, including innate immune response, positive regulation of NF-kappaB transcription factor activity and canonical NF-kappaB signaling, defense response to virus, and MHC class I biosynthesis. Autophagy and regulation of ubiquitin-dependent protein catabolic process also align with immune regulation, suggesting a group of proteins involved in innate antiviral defense and NF-kB\u2013driven inflammatory signaling. Some plant-specific terms appear as noise but do not define the core function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0051092","count":6},{"id":"GO:0045345","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0043123","count":5}]},{"hash":"41028857853339719","title":"Unknown","description":"The Top Terms span diverse processes including integrin signaling, junction assembly, trophoblast differentiation, complement activation, growth regulation, fibrinolysis, chloroplast and mitochondrial protein handling, and responses to food, with no clear shared function or pathway linking them. The cluster has no edges or connectivity to suggest a cohesive biological role, so no single representative theme is evident.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":2},{"id":"GO:0090528","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0030307","count":2}]},{"hash":"55964922280829134","title":"Auditory Neural Signaling and Synaptic Transmission","description":"The cluster centers on sensory and neural communication: detection of sound-related stimuli, excitatory and inhibitory synaptic signaling (glutamatergic/excitatory potentials, GABA, serotonin, dopamine pathways), and ion transport through channels, all indicative of neuronal signaling and auditory processing, with related behavioral terms like locomotion and taste aversion supporting neural circuit involvement.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":11},{"id":"GO:0071805","count":11},{"id":"GO:0007626","count":11},{"id":"GO:0001661","count":11},{"id":"GO:0035725","count":11}]},{"hash":"428386109396657724","title":"Drosophila embryogenesis and germline formation","description":"This cluster's GO terms center on maternal axis specification and pole cell formation during Drosophila embryogenesis, plus stem cell proliferation, suggesting a theme of early insect development and germline formation; other terms reflect shared regulatory processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007311","count":1},{"id":"GO:0007279","count":1},{"id":"GO:0045998","count":1},{"id":"GO:0007014","count":1},{"id":"GO:0018032","count":1}]},{"hash":"2111338619709340827","title":"Pain sensing and ubiquitin signaling","description":"The cluster is driven by nociception-related terms (detection of mechanical and chemical stimuli involved in pain), indicating pain-sensing functions. It additionally features ubiquitination and proteasomal protein turnover, along with calcium release and cytokine signaling, suggesting a theme where pain signaling is tied to ubiquitin-regulated protein activity and inflammatory/calcium signaling. Some terms (like SA node action potential regulation) may reflect shared signaling components or annotation breadth rather than a core function, so the core theme appears to be nociceptive signaling coupled with ubiquitin-mediated regulation. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":5},{"id":"GO:0071260","count":4},{"id":"GO:0050968","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0098907","count":4}]},{"hash":"25243146927087375","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043569","count":8},{"id":"GO:1902187","count":7},{"id":"GO:0007014","count":7},{"id":"GO:2000637","count":7},{"id":"GO:0001778","count":7}]},{"hash":"468652497032316278","title":"DNA transcription and mitotic/cytoskeletal remodeling","description":"The cluster is driven by GO terms for DNA-templated transcription, mitotic spindle assembly, and actin filament depolymerization, pointing to core processes of transcriptional regulation coupled to cell division and cytoskeleton dynamics. The presence of tissue-specific development terms (male genitalia, hippocampus, heart) may reflect broad, cross-tissue roles or annotation bias in some proteins, but the dominant themes tie to genome regulation and mitosis-associated cytoskeletal changes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0090307","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0030539","count":2},{"id":"GO:0021766","count":2}]},{"hash":"2036585053923803508","title":"Developmental Signaling and Morphogenesis","description":"The GO terms converge on signaling pathways that guide tissue and organ morphogenesis (nerve growth factor signaling, midbrain and pericardial morphogenesis, endothelial barrier formation) and related cellular responses (cAMP signaling), with some immune-regulatory terms appearing ancillary. This suggests a broad theme of developmental signaling across tissues rather than a single pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038180","count":1},{"id":"GO:0050774","count":1},{"id":"GO:0071320","count":1},{"id":"GO:1902715","count":1},{"id":"GO:0033089","count":1}]},{"hash":"188330255061497436","title":"Cell Signaling Regulation","description":"This cluster centers on GO terms related to signaling pathways and their regulation (ERK cascade, insulin/IGF receptor signaling, cAMP response), with additional terms touching development processes like dendrite and microvillus assembly. The common thread is modulation of signal transduction rather than a single molecular function or complex, suggesting these proteins participate in broader signaling regulation and related differentiation processes; the lack of observed interactions also supports a functional grouping by signaling roles rather than physical association.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0045987","count":2},{"id":"GO:0046626","count":2},{"id":"GO:0051591","count":2}]},{"hash":"925546405936259314","title":"ER Proteostasis and Membrane Targeting","description":"Top GO terms point to protein folding quality control, unfolded protein response, and SRP-dependent targeting to the ER membrane, indicating a cluster focused on ER-associated proteostasis and trafficking. While a few terms are more general or unrelated (e.g., iron-sulfur metabolism, DNA replication), the dominant signal is proteins involved in managing protein folding, ER stress signaling, and cotranslational targeting to membranes. This supports a label of ER proteostasis and membrane targeting.","confidence":"High","size":18,"edges":55,"triangles":54,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0090084","count":7},{"id":"GO:1903382","count":7},{"id":"GO:0006880","count":7},{"id":"GO:0016226","count":7}]},{"hash":"1421078251421093380","title":"Ubiquitin-Dependent Protein Turnover","description":"Most proteins in this cluster are annotated with ubiquitin-related processes, including ubiquitin-dependent protein catabolic process, various deubiquitination activities (K6- and K29-linked), and free ubiquitin chain depolymerization, pointing to a shared function in ubiquitin signaling and protein degradation. A few terms (necroptosis, CNS morphogenesis, fear response) are peripheral annotations that likely reflect multifunctionality or annotation noise; they do not override the central ubiquitin-centric theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035616","count":1},{"id":"GO:0051568","count":1},{"id":"GO:1901026","count":1},{"id":"GO:1900425","count":1},{"id":"GO:0044313","count":1}]},{"hash":"1357366120636807609","title":"Embryonic patterning and organ development","description":"The terms converge on developmental biology, including left/right patterning, cartilage morphogenesis, pancreatic cell development, trophoblast differentiation, and EMT in heart/endocardial cushion formation, all pointing to embryogenesis and organ formation. A few metabolism/immune terms are present but do not override the core patterning/organogenesis signal.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060707","count":1}]},{"hash":"2169295789173844202","title":"Neuronal synaptic plasticity and receptor trafficking","description":"The cluster\u2019s top GO terms center on neural function and synaptic regulation, including visual learning, social behavior, and long-term synaptic depression, along with receptor internalization. These collectively suggest a focus on synaptic signaling and plasticity in neurons, with some ancillary transport processes that are less defining. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070212","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0031623","count":2}]},{"hash":"878780055390163019","title":"Mitochondria-Driven Stress and Apoptosis Signaling","description":"The top GO terms emphasize mitochondrial dynamics and intrinsic apoptosis (mitochondrial outer membrane permeabilization; ER stress-induced apoptotic signaling) along with stress-activated signaling (JNK cascade) and exosomal secretion, suggesting a core theme of mitochondria-associated stress responses leading to apoptosis. Some terms about migration and ectodermal fate are present but less central to the main cluster function.","confidence":"Medium","size":18,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001713","count":1},{"id":"GO:0045893","count":1},{"id":"GO:0010762","count":1},{"id":"GO:0048312","count":1},{"id":"GO:1990182","count":1}]},{"hash":"2261471948180301429","title":"Unknown","description":"The cluster includes GO terms across neuronal development, coagulation, reproduction, GPCR signaling, ECM organization, and cytoskeleton regulation, with no single dominant process, suggesting no cohesive theme to title the cluster meaningfully.","confidence":"","size":18,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0007213","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007566","count":2}]},{"hash":"1678889425431709109","title":"Actin-Driven Membrane Remodeling","description":"This cluster centers on GO terms for actin filament organization and cytoskeleton reorganization, combined with membrane-associated processes like plasma membrane tubulation, endocytosis regulation, and lipid tube assembly involved in organelle fission, all pointing to coordinated actin remodeling with membrane dynamics. A few terms (visual perception, multicellular development) are broader annotations that may reflect wider roles or annotation noise, but the dominant theme coherently links cytoskeletal rearrangement to membrane remodeling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0007015","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0097320","count":3},{"id":"GO:0000278","count":3}]},{"hash":"2104967707135723744","title":"Neural development and synaptic signaling","description":"This cluster is dominated by GO terms tied to nervous system development and synaptic function, including axon guidance, Schwann cell and retina development, radial glia\u2013neuronal interactions, and cholinergic GPCR signaling with receptor clustering. While a few terms touch on broader developmental processes (podocyte, brown fat, lung), the prominent neural-patterning and synaptic-related terms suggest a coherent neural development/synaptic signaling theme.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:1905815","count":5},{"id":"GO:0072249","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0032224","count":5},{"id":"GO:0014044","count":5}]},{"hash":"2243117745895640917","title":"RNA processing and translation initiation network","description":"The dominant GO terms cluster around RNA processing (small-subunit processome assembly, mRNA polyadenylation, mRNA export) and translation initiation (eIF4F complex assembly, IRES-dependent initiation, regulation of initiation), suggesting a module that links RNA biogenesis with translation control.","confidence":"Medium","size":18,"edges":87,"triangles":195,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0034462","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0097010","count":2},{"id":"GO:0075522","count":2}]},{"hash":"1605402892762834633","title":"Mitotic Cell Cycle and Division","description":"The top GO terms are dominated by cell division, mitotic cell cycle, and metaphase/anaphase transition, pointing to a cohesive theme around mitosis and chromosome segregation. Additional terms for protein ubiquitination and histone modification align with cell-cycle control and chromatin regulation, though some outliers (innate immune response, prostate development) may reflect multifunctional annotations or broader roles of the proteins. Overall, the cluster appears focused on mitotic processes with supporting regulatory activities.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000278","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0046661","count":3},{"id":"GO:0006463","count":3}]},{"hash":"1137458441740643299","title":"Embryonic organ and tissue morphogenesis","description":"These proteins show GO terms centered on morphogenesis and development across diverse embryonic tissues and organs (eye, hindlimb, heart/outflow tract, placenta, habenula, prostate). The shared theme is collective involvement in embryonic tissue formation rather than a single pathway, supporting a developmental role across multiple organ systems.","confidence":"High","size":18,"edges":104,"triangles":276,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0008584","count":7},{"id":"GO:0035116","count":6},{"id":"GO:0001890","count":6}]},{"hash":"1988121508926899020","title":"Neural signaling and brain development","description":"The top GO terms point to nervous system signaling (GABA receptor clustering, serotonin signaling, dopamine secretion), neuronal ion transport, autonomic heart-rate regulation, and development of brain-related structures (lateral geniculate nucleus, vestibulocochlear nerve), indicating a cohesive theme of neuronal communication and brain development.","confidence":"High","size":18,"edges":9,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":8},{"id":"GO:0007626","count":8},{"id":"GO:0002087","count":8},{"id":"GO:0097112","count":8},{"id":"GO:0007210","count":7}]},{"hash":"762878362507078194","title":"Ribosome and Translation Regulation","description":"This cluster is dominated by GO terms related to protein synthesis and ribosome dynamics, including cytoplasmic and mitochondrial translation, translational elongation, and ribosome disassembly, with mRNA decay tied to translation. Selenocysteine incorporation also points to specialized translation. A few outliers exist but do not outweigh the core theme of translation machinery and its regulation.","confidence":"High","size":18,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0001889","count":3},{"id":"GO:1902802","count":2},{"id":"GO:0001514","count":2}]},{"hash":"605623373231761541","title":"Organ Development and Signaling","description":"The proteins are linked to multiple organ developmental processes (retina vasculature, heart, uterus) and associated signaling pathways (KIT, neurotrophin/TRK, STAT), with additional terms for cell adhesion and stress response. This suggests a broad, multi-tissue developmental signaling theme rather than a single cohesive pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0061298","count":7},{"id":"GO:0043552","count":5},{"id":"GO:0010863","count":5},{"id":"GO:0038109","count":5},{"id":"GO:0007507","count":5}]},{"hash":"577806412928746427","title":"Neural development and axon guidance signaling","description":"The terms cluster around neural development and axon pathfinding: paranode localization, axon guidance (including retinal ganglion cell axon guidance), and regulation of extracellular matrix disassembly, suggesting a focus on neural connectivity. Additional terms reflect related signaling and transcriptional regulation (Wnt signaling, DNA-templated transcription) that commonly participate in neural development, with a few broader cellular processes appearing as incidental context. Overall, the dominant theme is neural development and axon guidance.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0090263","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045071","count":2},{"id":"GO:0006659","count":1}]},{"hash":"439929200736072274","title":"RNA processing and translation initiation","description":"These terms cluster around RNA metabolism and the control of translation: regulatory ncRNA-mediated gene silencing, regulation of mRNA splicing via spliceosome, formation of translation preinitiation complex, translation reinitiation, small-subunit processome assembly, eIF4F complex assembly, IRES-dependent viral translation initiation, and mRNA export, with blastocyst formation reflecting developmental expression. Together they point to proteins involved in RNA maturation and initiation of protein synthesis, justifying the label.","confidence":"High","size":18,"edges":108,"triangles":332,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":13},{"id":"GO:0048026","count":13},{"id":"GO:0001731","count":11},{"id":"GO:0002188","count":11},{"id":"GO:0034462","count":10}]},{"hash":"35175525915844294","title":"Axon Guidance and Embryonic Organogenesis","description":"The most represented terms cluster around axon extension, localization to the juxtaparanode, and paranodal junction assembly, indicating a central theme of axon guidance and neuronal connectivity. Additional terms cover embryonic organ morphogenesis (heart valve and coronary artery development) and loop of Henle development, suggesting the cluster also captures broader embryonic development processes. Overall, the dominant signal is axon guidance with accompanying organogenesis processes.","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071205","count":11},{"id":"GO:0048846","count":11},{"id":"GO:0030913","count":11},{"id":"GO:0014909","count":11},{"id":"GO:0060982","count":11}]},{"hash":"2291857883123031716","title":"ER Protein Folding and Stress Response","description":"The cluster is dominated by GO terms related to protein folding quality control in the endoplasmic reticulum, including cellular response to unfolded protein, SRP-dependent targeting to the ER membrane, and regulation of ER-stress\u2013related apoptotic signaling. While a few terms touch on oxidative stress and unrelated processes such as fungal cell wall biosynthesis and karyogamy, the prevailing theme is managing nascent protein folding and ER-associated stress responses, suggesting a cohesive functional cluster around ER protein handling.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":15},{"id":"GO:1903382","count":15},{"id":"GO:0006880","count":15},{"id":"GO:0016226","count":15},{"id":"GO:0034620","count":15}]},{"hash":"1674252876916934131","title":"Extracellular matrix remodeling and cell adhesion","description":"Based on the prominent ECM-related terms (hyalu ronan metabolism, negative regulation of ECM assembly, cell-matrix adhesion, extracellular extravasation) along with vascular/immune processes (blood coagulation, complement activation) and even a note on dendrite regeneration, the cluster appears to group proteins involved in ECM dynamics, cell adhesion, and associated vascular-immune interactions. The dendrite term is peripheral but may reflect ECM influence on neural repair. Overall, it\u2019s a coherent ECM/adhesion and vascular-immune module.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032508","count":4},{"id":"GO:0090305","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0030212","count":4},{"id":"GO:0045123","count":4}]},{"hash":"2084771757446181363","title":"Mitochondrial regulation of neural development and function","description":"This cluster centers on mitochondrial processes (protein import into the mitochondrial matrix, calcium import, mitophagy, ROS regulation) and neural development/signaling (neuron-neuron synaptic transmission, learning). Developmental terms like embryonic development and fin regeneration may reflect broader roles for mitochondria in growth and tissue remodeling. The shared focus on mitochondrial function that influences neural activity and development underpins the chosen label.","confidence":"High","size":18,"edges":13,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:2000378","count":3},{"id":"GO:0001701","count":2},{"id":"GO:0031101","count":2},{"id":"GO:1902017","count":2}]},{"hash":"186552446127958534","title":"Platelet lineage development and immune signaling","description":"The top GO terms cluster around platelet formation, megakaryocyte development, PDGFR-beta signaling, and integrin-mediated adhesion regulation, indicating platelet lineage biology. Additional terms for NK cell cytotoxicity and TLR3 signaling suggest broader immune signaling involvement, with some tissue migration and neural development terms likely reflecting broader adhesion and developmental roles of these proteins.","confidence":"Medium","size":18,"edges":17,"triangles":5,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0033629","count":10},{"id":"GO:0033277","count":10},{"id":"GO:0035791","count":10},{"id":"GO:0033630","count":10},{"id":"GO:0061582","count":10}]},{"hash":"1425867443742711196","title":"Arabinogalactan Protein Biosynthesis and Root Hair Development","description":"This cluster is dominated by terms related to Arabinogalactan Proteins (AGPs), AGP metabolic processes, and related cell-wall glycoprotein modifications (e.g., hydroxyproline O-glycosylation), plus processes like root hair development and seed coat mucilage biosynthesis. Those terms point to plant cell wall glycoprotein biosynthesis and epidermal differentiation as the common theme. Some terms (e.g., base-excision repair, DNA recombination, infection structure formation) are discordant and likely represent background noise. ","confidence":"Medium","size":18,"edges":124,"triangles":450,"max_degree":17,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0075015","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0030311","count":4}]},{"hash":"410568234417428023","title":"Inflammation and Prostaglandin GPCR Signaling","description":"These proteins are annotated with GO terms centered on inflammatory responses (inflammatory response, blood coagulation), prostaglandin E stimulus, and regulation of GPCR signaling, along with downstream calcium signaling and IL-1\u03b2 production. The convergence on prostaglandin-mediated GPCR signaling and inflammatory processes, plus related pain and thermogenesis cues, suggests a cohesive inflammatory signaling cluster.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0071380","count":9},{"id":"GO:0006954","count":9}]},{"hash":"435973887388205007","title":"Mitotic Division and Development","description":"Based on the top GO terms, the cluster is dominated by mitotic cell cycle and cell division signals (mitosis) such as mitotic cell cycle, cell division, and anaphase-promoting complex\u2013dependent catabolic processes. There are also development-related terms (fertilization, retina, and gonad development) and a defense/cadmium response term among the set, but the strongest and most frequent theme is cell division and mitotic control, with development terms likely reflecting broader roles in growth and differentiation. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0007338","count":6},{"id":"GO:0050830","count":5},{"id":"GO:2001162","count":5}]},{"hash":"1659435581443485891","title":"Mitochondrial gene expression and tRNA charging","description":"The cluster shows strong enrichment for mitochondrial-related processes: mitochondrial tRNA aminoacylation for Thr, Gly, Ser, Pro; translation and transcription activities; regulation of translational fidelity; and energy production via proton motive force-driven ATP synthesis, indicating a cohesive mitochondrial gene expression and protein synthesis module, with supporting tRNA charging and related biosynthetic steps.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0015986","count":2},{"id":"GO:0006450","count":2},{"id":"GO:0015966","count":2}]},{"hash":"2096471493388879480","title":"Unknown","description":"There is no single cohesive function tying these proteins together: the top GO terms span ribosomal RNA maturation, protein complex assembly, GTPase regulation, hypoxia and TGF-beta signaling responses, epithelial proliferation, defense against Gram-positive bacteria, histone methylation, and cellular fusion. With no edges or connectivity, the cluster appears heterogeneous rather than a unified pathway, so an Unknown label is appropriate.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070208","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0000463","count":5},{"id":"GO:0060770","count":5}]},{"hash":"316369765272259831","title":"Developmental cell cycle proteins","description":"This cluster is dominated by cell division and cell cycle terms (GO:0051301, GO:0007049), with additional developmental themes (nervous system and kidney development) and Hedgehog-related signaling (Smoothened). Mitochondrial dynamics and ribosomal export appear as supporting processes, but the core theme centers on cell cycle\u2013driven development.","confidence":"High","size":18,"edges":3,"triangles":0,"max_degree":3,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0000055","count":5},{"id":"GO:0001822","count":5}]},{"hash":"1734717243673458337","title":"NF-kappaB and Nuclear Receptor Signaling Regulators","description":"This cluster is governed by terms related to regulation of NF-kappaB signaling and retinoic acid receptor signaling (nuclear receptor pathways), with additional signals from SMAD-related phosphorylation, autophagy, and ubiquitin-mediated proteolysis. The mix suggests a group of proteins that broadly regulate signaling pathways and transcriptional responses, though some terms reflect developmental processes in different kingdoms, hence a moderate level of confidence.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0048384","count":5},{"id":"GO:0007182","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0007026","count":5}]},{"hash":"295911667555641008","title":"Innate immune response and autophagy regulation","description":"The most represented terms are innate immune response (GO:0045087) and autophagy (GO:0006914), suggesting a functional theme around host defense and protein turnover via autophagy. The presence of IL-17 signaling and regulation of ubiquitin-dependent proteolysis supports an immune signaling and degradation-control role. Some other terms (plant brassinosteroid signaling, placental morphogenesis, miRNA metabolism) may reflect broader multifunctionality or cross-species annotations, but the core cluster centers on innate immunity and autophagy regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0006914","count":5},{"id":"GO:1900458","count":5},{"id":"GO:0072089","count":5},{"id":"GO:2000059","count":5}]},{"hash":"2108685974324392783","title":"Organogenesis and BMP Signaling Regulators","description":"The cluster is enriched for GO terms related to embryonic development, especially heart and skeletal system development, cranial skeleton morphogenesis, and positive regulation of BMP signaling, suggesting a group involved in organ formation and developmental signaling. Some terms also point to transcription and cell cycle processes, but the dominant theme is developmental regulation and morphogenesis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0048701","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0007275","count":4}]},{"hash":"158253088590854795","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0072089","count":10},{"id":"GO:0010586","count":10},{"id":"GO:0051092","count":10},{"id":"GO:0035372","count":10},{"id":"GO:2000637","count":10}]},{"hash":"1110260947711897291","title":"Glycosaminoglycan and Proteoglycan Biosynthesis","description":"The top GO terms are heavily weighted toward glycosaminoglycan and proteoglycan biosynthesis (keratan sulfate proteoglycan, dermatan/chondroitin sulfate biosynthesis) and embryonic neurocranium morphogenesis, pointing to extracellular matrix proteoglycan production and related developmental processes as the core theme of this cluster. Other metabolic terms appear broad and less central, but do not override the clear proteoglycan/ECM signal.","confidence":"High","size":18,"edges":88,"triangles":206,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0048702","count":10},{"id":"GO:0002002","count":10},{"id":"GO:0030205","count":10},{"id":"GO:0018146","count":10},{"id":"GO:0030206","count":10}]},{"hash":"1391494781902299773","title":"GPCR-driven cGMP and cAMP Signaling","description":"This cluster is centered on G protein-coupled receptor pathways and second-messenger signaling. The top terms emphasize adenosine GPCR signaling, receptor guanylyl cyclase signaling, cGMP biosynthesis, and forskolin-induced cAMP responses, with supporting terms for intracellular signal transduction and sensory/blue light signaling. Together these point to a cohesive theme of GPCR-mediated signaling through cGMP and cAMP pathways, including elements of phototransduction and transcriptional regulation downstream of these signals.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001973","count":12},{"id":"GO:1904322","count":12},{"id":"GO:0030828","count":12},{"id":"GO:0007168","count":12},{"id":"GO:0052565","count":12}]},{"hash":"1414242886510586698","title":"Lipid and carbohydrate biosynthesis","description":"The cluster\u2019s top GO terms center on diverse biosynthetic pathways for lipids (sterol, wax, PHB) and sugars (galactose, rhamnose, ADP-L-glycero-manno-heptose), with a stray transcription-associated term suggesting regulatory roles. This mix points to proteins involved in multiple biosynthetic routes rather than a single, narrow function, so a broad label like lipid and carbohydrate biosynthesis fits best.","confidence":"Medium","size":18,"edges":58,"triangles":16,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0042619","count":4},{"id":"GO:0016126","count":3},{"id":"GO:0033499","count":3}]},{"hash":"1320702203294137664","title":"Dopaminergic signaling and cocaine-related behavior","description":"This cluster is dominated by neural-related GO terms: dopaminergic synaptic transmission, locomotory behavior, visual learning, and behavioral response to cocaine, plus related signaling (ERK cascade, protein phosphorylation). While a few terms touch on peripheral processes, the strongest and most coherent theme is dopamine-mediated neuronal signaling and reward/behavior, suggesting proteins function together in neural signaling and cocaine-associated behaviors.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":6},{"id":"GO:0010759","count":5},{"id":"GO:0071380","count":5},{"id":"GO:0006468","count":5},{"id":"GO:0070374","count":5}]},{"hash":"710234061574553786","title":"Notch-regulated morphogenesis and cell adhesion","description":"This cluster centers on developmental signaling and tissue formation, highlighted by negative regulation of Notch signaling and receptor clustering, plus multiple morphogenesis terms across lung, pericardium, hair, and smooth muscle contexts, as well as cell\u2013cell adhesion. Anomalous terms like learning or detoxification may reflect shared or incidental annotations but do not override the overall developmental/adherence theme.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045746","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0098869","count":4},{"id":"GO:0007612","count":4},{"id":"GO:0003344","count":4}]},{"hash":"1027211129281748459","title":"Developmental Signaling Across Tissues","description":"This cluster emphasizes broad developmental and signaling processes across multiple tissues, including angiogenesis, skeletal muscle and skin development, and nervous system development, alongside integrin- and B cell receptor\u2013mediated signaling and cell-cycle-related processes. The mix suggests a conglomerate of proteins involved in general developmental programs rather than a single tissue-specific function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0007519","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0050853","count":3}]},{"hash":"2267742697651350455","title":"Vertebrate Embryonic Organogenesis","description":"The top GO terms point to development of multiple vertebrate organs (pituitary, neural crest derivatives, pancreas, ureteric bud, digestive tract) and regulation of transcription during embryogenesis, suggesting a common theme of embryonic organogenesis and developmental gene regulation.","confidence":"High","size":18,"edges":48,"triangles":28,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":9},{"id":"GO:0090190","count":7},{"id":"GO:2000288","count":6},{"id":"GO:0021986","count":6},{"id":"GO:0006355","count":6}]},{"hash":"1254575355107284850","title":"Antiviral dsRNA sensing and defense","description":"These proteins appear tied to innate antiviral responses, as indicated by GO terms for cellular response to exogenous dsRNA and defense response to virus, along with receptor clustering and memory that can relate to signaling complexes and immune memory. Some terms like eye development are less central and may reflect broad annotations, but the predominant theme is dsRNA sensing and antiviral defense.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043010","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0007157","count":3},{"id":"GO:0050873","count":3},{"id":"GO:0043113","count":3}]},{"hash":"15512963533289673","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":8},{"id":"GO:0007014","count":8},{"id":"GO:2000637","count":8},{"id":"GO:0043569","count":8},{"id":"GO:0061158","count":8}]},{"hash":"2302817264540338249","title":"Ubiquitin-mediated antiviral defense","description":"Most frequent terms are ubiquitin-dependent protein catabolic process and protein ubiquitination, plus innate antiviral responses (defense response to virus, innate immune response, response to dsRNA), suggesting a cluster of proteins involved in ubiquitin-proteasome\u2013mediated regulation of antiviral defense. An outlier term about camera-type eye development appears incidental and does not redefine the cluster's main theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0033280","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0071360","count":6},{"id":"GO:0030433","count":5}]},{"hash":"207517135322589019","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0061158","count":7},{"id":"GO:1902187","count":7},{"id":"GO:2000637","count":7},{"id":"GO:0007014","count":7},{"id":"GO:0010586","count":6}]},{"hash":"347007749478671097","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0002107","count":4},{"id":"GO:0000289","count":4},{"id":"GO:0000467","count":4},{"id":"GO:0010606","count":4},{"id":"GO:0006261","count":4}]},{"hash":"2257209973825562919","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":8},{"id":"GO:2000637","count":8},{"id":"GO:0061158","count":8},{"id":"GO:1902187","count":8},{"id":"GO:0018032","count":6}]},{"hash":"1853089492358476912","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":14},{"id":"GO:0007014","count":14},{"id":"GO:2000637","count":14},{"id":"GO:0061158","count":14},{"id":"GO:0006914","count":13}]},{"hash":"314218456245660006","title":"TLR/MyD88-Dependent Transcriptional Regulation","description":"Reasoning: The cluster's top GO terms center on DNA-templated transcription and its regulation, with a clear signal from MyD88-dependent Toll-like receptor signaling and positive regulation of TNF production, pointing to innate immune signaling driving transcriptional programs. Pale hints of histone acetylation suggest potential chromatin remodeling accompanying transcriptional activation. The manganese ion response is incidental. Overall, this suggests a module of innate immune signaling converging on transcriptional control.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0002755","count":2},{"id":"GO:0032760","count":2},{"id":"GO:0043982","count":1}]},{"hash":"1311582877310662957","title":"Innate Immune Activation and Cytoskeletal Signaling","description":"The top GO terms are dominated by innate immune responses (defense against Gram-positive bacteria, LPS detection, macrophage activation, dendritic cell cytokine regulation) and cytoskeletal dynamics (actin filament severing), with TORC1-related metabolic signaling also linking to immune cell function. Some terms (splicing, gonad/kidney development) are less directly related, suggesting multifunctional proteins or annotation noise, but the core pattern points to immune activation and cytoskeletal/metabolic regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:1904263","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0032497","count":1}]},{"hash":"2022259771527626719","title":"Ubiquitin-Dependent Proteolysis and Circadian Regulation","description":"The top GO terms are dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, protein autoubiquitination, ERAD), indicating proteostasis driven by ubiquitination. The presence of a circadian rhythm regulation term suggests a connection to clock protein turnover, a context where ubiquitination governs protein stability. Together, these points indicate a cohesive theme around ubiquitin-mediated degradation with a circadian regulation component.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0051865","count":8},{"id":"GO:0051260","count":7},{"id":"GO:0042752","count":7},{"id":"GO:1901253","count":7}]},{"hash":"1848249056180096215","title":"Neuro-immune signaling and development","description":"This cluster combines neural functions (axonogenesis, neurotransmitter secretion, visual perception) with immune-related roles (innate immunity, defense against virus/bacteria, dendritic cell cytokine regulation) and signaling modulation (GPCR-PKC pathway, NF-kB signaling, kinase activity regulation). The overlap suggests proteins involved in the interplay between neural signaling and immune responses, rather than a single isolated function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1282888982697111237","title":"RNA Processing and Translation Initiation","description":"These terms cluster around RNA metabolism and control of gene expression at the level of RNA processing and translation: mRNA export, polyadenylation, small-subunit processome assembly, eIF4F complex assembly, and regulation of translational initiation (including IRES-dependent initiation). Together, they point to a cohesive module involved in ribosome biogenesis and post-transcriptional regulation of protein synthesis, with auxiliary hints of broader regulatory contexts like xenobiotic response. Confidence: Medium","confidence":"","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033234","count":2},{"id":"GO:0014718","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0034462","count":1},{"id":"GO:0006378","count":1}]},{"hash":"613208611374323445","title":"Neural Development and Signaling","description":"The cluster is dominated by terms tied to neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration) and key signaling pathways (insulin receptor and T cell receptor signaling). Additional terms about cell cycle/kinetochore localization and proliferation regulation suggest broader roles in development and cell proliferation, not limited to the nervous system. Overall, this set appears to capture developmental signaling with a neural emphasis.","confidence":"Medium","size":17,"edges":131,"triangles":612,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021697","count":14},{"id":"GO:0050852","count":14},{"id":"GO:0008285","count":14},{"id":"GO:2001275","count":14},{"id":"GO:0048679","count":14}]},{"hash":"2215743800542769248","title":"Unknown","description":"The proteins map to a highly diverse set of GO terms (cell division and mitotic chromosome alignment; cilium beat regulation; sebaceous gland development; palmitoylation; vacuole fusion; GPCR signaling regulation; gluconeogenesis regulation), with no clear shared function or pathway and no interactions, so there is no coherent theme to label beyond Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0007080","count":2},{"id":"GO:0090116","count":1},{"id":"GO:0048733","count":1},{"id":"GO:0018230","count":1}]},{"hash":"218981019346145244","title":"Phagocytosis and NF-\u03baB immune signaling","description":"The cluster\u2019s top GO terms cluster around immune functions: positive regulation of phagocytosis, phagocytosis recognition, B cell homeostasis, and lymph node development, plus activation of NF-\u03baB\u2013related signaling. This suggests a coherent theme of immune signaling that modulates phagocytosis via the NF-\u03baB pathway, with membrane/cilium localization reflecting receptor placement. Some terms may be broader or ancillary, but the dominant signal is phagocytosis linked to NF-\u03baB\u2013mediated immunity.","confidence":"Medium","size":17,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050766","count":3},{"id":"GO:0048535","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0001782","count":2}]},{"hash":"35451153716408516","title":"Gene expression regulation and chromatin modification","description":"The dominant terms are DNA-templated transcription and histone methylation, plus mRNA splicing, indicating regulation of gene expression at transcriptional and post-transcriptional levels. Additional terms (Wnt signaling, GPCR pathway regulation, osteoblast differentiation, nutrient response) suggest broader regulatory roles tied to signaling and development. Overall, the cluster appears to reflect regulatory modules controlling gene expression via chromatin state and RNA processing.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0051568","count":2},{"id":"GO:0051567","count":2},{"id":"GO:0034729","count":2}]},{"hash":"2101633515005045003","title":"Ubiquitin-mediated antiviral signaling and autophagy","description":"Proteins in this cluster are enriched for innate immune response and antiviral defense, with prominent ubiquitination-related processes (K63-linked ubiquitination, autoubiquitination, ubiquitin-dependent proteolysis) and autophagy, plus regulation of NF-kappaB signaling and suppression of viral release. This combination points to a coherent theme of ubiquitin-driven antiviral signaling and autophagic responses.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901253","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0070534","count":5},{"id":"GO:1903762","count":5},{"id":"GO:0045087","count":5}]},{"hash":"353113827364389912","title":"Placental labyrinthine vascular development","description":"The top GO terms include labyrinthine layer blood vessel development and branching involved in labyrinthine layer morphogenesis, which strongly point to placental vascular remodeling. Additional terms like regulation of bicellular tight junction assembly and positive regulation of the Wnt signaling pathway support coordinated epithelial barrier formation and signaling during placental morphogenesis, with prostaglandin-responsive signaling further tying into inflammatory/regulatory cues in placental tissue. While some terms are general (translation regulation, transcription factor activity), the placenta-focused terms dominate the theme, suggesting a cluster related to placental labyrinthine vascular development and morphogenesis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006449","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0034260","count":2},{"id":"GO:0042220","count":2}]},{"hash":"1700041468037011904","title":"Viral entry, genome integration, and cell cycle","description":"The cluster prominently features GO terms tied to viral processes: viral penetration into the host nucleus, DNA transposition, DNA integration, and establishment of integrated proviral latency, along with cell cycle and cell division terms. This combination points to proteins involved in viral/symbiont entry, genome integration, and modulation of the host cell cycle, with some additional translation and regulatory signals that may accompany those processes. Confidence: High","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0039651","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0075732","count":3}]},{"hash":"2075872849278610951","title":"Embryonic organ morphogenesis and transcription","description":"The top GO terms cluster around developmental morphogenesis (nephron tubule morphogenesis, S-shaped body morphogenesis, umbilical cord morphogenesis, pancreatic A cell fate commitment) and transcriptional control (transcription by RNA polymerase II). Other terms reflect associated regulatory and stress-responsive processes (oleic acid and xenobiotic responses, circadian regulation of heart rate, and double-strand break repair), suggesting a developmental program driven by transcriptional regulation.","confidence":"Medium","size":17,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0003326","count":15},{"id":"GO:0003053","count":15},{"id":"GO:0048712","count":15},{"id":"GO:0071400","count":15}]},{"hash":"471389712658483175","title":"Developmental growth signaling and proliferation","description":"This cluster's top GO terms emphasize growth-related signaling and tissue development (TORC1 signaling; mitotic cell cycle; cell population proliferation; responses to growth hormone; skin and seminiferous tubule development). A couple of terms are broader cellular processes (mRNA transport; cellular response to hypoxia) that can occur alongside development. Overall, the common theme is growth, development, and cellular proliferation signals.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0051028","count":3},{"id":"GO:0071456","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0072520","count":2}]},{"hash":"1093784272922293075","title":"Neuronal membrane transporters (ions and sugars)","description":"The Top Terms show transmembrane transport of ions (potassium, sodium), various sugars (glucose, galactose), and amino acids (proline), plus a neural signaling term (glutamatergic synaptic transmission) and related neural processes (visual learning, ethanol response). This pattern points to a set of transporter proteins with roles in neuronal membrane transport and neural signaling. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0015824","count":2}]},{"hash":"2150060942856647327","title":"Membrane amino acid and ion transporters","description":"The terms show amino acid import (lysine, arginine), GABA transport, and chloride/ion transport across membranes, plus carnitine transmembrane transport\u2014together pointing to membrane transport proteins. A few terms reflect broader cellular contexts (mitotic chromosome condensation, synaptic transmission) but do not override the dominant transport theme.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007076","count":2},{"id":"GO:0015812","count":2},{"id":"GO:0097639","count":2},{"id":"GO:0030644","count":2},{"id":"GO:0030321","count":2}]},{"hash":"1238494826927819366","title":"Unknown","description":"The terms combine fatty acid/lipid metabolism and biosynthesis with plant-specific processes (seed germination, phenylpropanoid metabolism) and bacterial pathways (lipoteichoic acid, menaquinone), giving no single cohesive function for all proteins. Therefore I label Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0006564","count":3},{"id":"GO:0090410","count":3},{"id":"GO:0044539","count":3},{"id":"GO:0009698","count":3}]},{"hash":"2265862025521184278","title":"Ubiquitin-Dependent NF-\u03baB/JNK Signaling and Apoptosis","description":"The cluster is strongly enriched for ubiquitin-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, various ubiquitin linkages) and signaling events (regulation of JNK cascade, activation of NF-\u03baB-inducing kinase), as well as apoptotic regulation. This points to a group of proteins involved in ubiquitin-mediated regulation of key signaling pathways (NF-\u03baB and JNK) and cell fate decisions, with ancillary ties to immune processes (V(D)J recombination). Therefore, a concise label focusing on ubiquitin-driven signaling and apoptosis best captures the shared function.","confidence":"High","size":17,"edges":5,"triangles":2,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0051865","count":10},{"id":"GO:0046328","count":9},{"id":"GO:0070535","count":6},{"id":"GO:0042981","count":6}]},{"hash":"1535425684929407538","title":"Mitotic Regulation by Ubiquitin-Proteasome","description":"The cluster centers on mitosis and cell division (mitotic cell cycle, cell division) and is enriched for ubiquitin-related processes (protein ubiquitination, proteasome regulatory particle assembly, APC-dependent catabolic process), indicating regulation of mitosis via ubiquitin-proteasome\u2013mediated proteolysis. Additional terms like ER-to-Golgi transport and cadmium response are present but secondary to the core theme of cell-cycle control through ubiquitin-mediated degradation.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0030433","count":3},{"id":"GO:2001162","count":3},{"id":"GO:0071276","count":3}]},{"hash":"1502492535691560080","title":"Embryonic organogenesis and nervous system development","description":"The top GO terms point to development across multiple tissues (nervous system, heart, skeletal, lung mesenchyme) and include signaling pathways related to organogenesis (FGFR signaling) and synapse formation. This suggests a cohesive theme of embryonic development and tissue morphogenesis rather than a single, narrow function, justifying a label focused on multi-tissue organogenesis and neural development.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0031663","count":4},{"id":"GO:0035607","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1362054814080561340","title":"Innate Antiviral Defense and Autophagy","description":"The cluster is enriched for innate immune and antiviral defense terms (defense response to virus, innate immune response) with autophagy also represented, suggesting a core theme of antiviral defense mechanisms. While other terms like cell cycle and mitochondrial protein import appear, they are less central to the cluster\u2019s primary function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4},{"id":"GO:1903070","count":3},{"id":"GO:0022417","count":2}]},{"hash":"1997014678847017439","title":"Renal epithelial and photoreceptor cell differentiation","description":"The top GO terms largely point to differentiation and maintenance of specialized epithelial and sensory cells, including podocyte and nephron tubule epithelial differentiation and photoreceptor cell maintenance (eye). A few terms touch on other cellular processes (endocytosis regulation, telomere tethering, and nucleokinesis), but the dominant signal is differentiation of renal epithelial and photoreceptor cells, suggesting a theme around epithelial/sensory cell fate programs.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048550","count":1},{"id":"GO:0072112","count":1},{"id":"GO:0072139","count":1},{"id":"GO:0045494","count":1},{"id":"GO:2001287","count":1}]},{"hash":"257450414930009973","title":"Steroid Hormone Biosynthesis and Metabolism","description":"The top GO terms cluster around biosynthesis and metabolism of steroid hormones (estrogen, testosterone, glucocorticoids) and related steroid catabolic processes, indicating a cohesive theme of steroid biosynthesis and hormone regulation.","confidence":"High","size":17,"edges":11,"triangles":7,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0042619","count":7},{"id":"GO:0008207","count":6},{"id":"GO:0006703","count":6},{"id":"GO:0042761","count":6}]},{"hash":"1072792628937042923","title":"Xenobiotic Metabolism and P450 Epoxygenase Pathway","description":"The top GO terms reveal a clear link to detoxification and metabolism of foreign compounds, notably xenobiotic catabolic processes and the epoxygenase P450 pathway, suggesting a shared function in xenobiotic processing. Some other terms (cell cycle, development) appear less connected and may reflect noise or broader regulatory roles, but the strongest consistent signal centers on P450-mediated metabolism and xenobiotic processing.","confidence":"Medium","size":17,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035865","count":10},{"id":"GO:1900087","count":10},{"id":"GO:0033072","count":10},{"id":"GO:0010760","count":10},{"id":"GO:0042738","count":10}]},{"hash":"1629881014188605100","title":"Lipid Biosynthesis and Remodeling","description":"The top GO terms are dominated by lipid-related biosynthetic processes (phosphatidylcholine, ether lipids, cardiolipin, triglycerides, CDP-diacylglycerol) and lipid remodeling, pointing to a cluster centered on lipid metabolism and membrane composition. A few development-related terms appear, but they seem peripheral to the main signal.","confidence":"High","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002071","count":7},{"id":"GO:0006663","count":7},{"id":"GO:0010143","count":7},{"id":"GO:2001246","count":7},{"id":"GO:0019432","count":7}]},{"hash":"995646250242451727","title":"Developmental migration and morphogenesis","description":"This cluster emphasizes developmental cell movement and tissue morphogenesis across multiple contexts (muscle, epithelium, vasculature) with adhesion and junction organization. The recurrent themes are cell migration, morphogenesis, angiogenesis, and neuronal junctions, reflecting coordinated remodeling during development.","confidence":"Medium","size":17,"edges":27,"triangles":11,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014909","count":11},{"id":"GO:0060740","count":10},{"id":"GO:0051968","count":10},{"id":"GO:1990134","count":10},{"id":"GO:0002042","count":10}]},{"hash":"1829445295980801643","title":"Cerebellar neural development and glial differentiation","description":"The top GO terms strongly point to neural development in the cerebellum (cerebellar cortex formation, Bergmann glial differentiation) and glial/neuronal maturation (Schwann cell development, axon regeneration, excitatory postsynaptic potential), indicating a theme of CNS/PNS neural development and synaptic signaling. Some metabolic or immune-related terms appear but do not define the cluster's primary function.","confidence":"High","size":17,"edges":101,"triangles":324,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021697","count":12},{"id":"GO:0050852","count":12},{"id":"GO:0008285","count":12},{"id":"GO:2001275","count":12},{"id":"GO:0048679","count":12}]},{"hash":"1012055525065639918","title":"NF-kappaB/JNK-mediated immune signaling","description":"This cluster is enriched for GO terms tied to NF-\u03baB and JNK signaling, inflammatory responses, IL-17 production, and regulation of B and T cell functions, indicating an immune signaling and inflammation module. A peripheral term about tRNA export appears incidental. Overall, the label reflects an NF-\u03baB/JNK\u2013driven immune signaling theme.","confidence":"High","size":17,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046330","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0016064","count":3}]},{"hash":"1176413339211646404","title":"Wnt-driven EMT and ECM remodeling","description":"The cluster is dominated by Wnt signaling and processes related to extracellular matrix organization (fibronectin and collagen fibril organization) and epithelial-to-mesenchymal transition, along with endothelial cell migration and integrin signaling. This pattern suggests a coherent program of Wnt-mediated EMT coupled with ECM remodeling and cell adhesion/movement, with a few immune-related terms likely secondary. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":4},{"id":"GO:1905590","count":3},{"id":"GO:0001837","count":3},{"id":"GO:0010886","count":3},{"id":"GO:0030199","count":3}]},{"hash":"2219016704752147839","title":"Embryonic organ morphogenesis","description":"The top GO terms cluster around embryonic development and morphogenesis across multiple organs (pituitary gland, heart, cranial skeleton, hindlimb, eye, digestive tract, placenta, endocrine pancreas) plus neural crest migration and neuron survival. This suggests the proteins broadly participate in embryonic organ formation rather than a single tissue-specific pathway, hence a label emphasizing multi-organ morphogenesis. ","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0043524","count":5},{"id":"GO:0048701","count":5},{"id":"GO:0035116","count":5},{"id":"GO:0001890","count":5}]},{"hash":"1927693181095490575","title":"Vascular development and endothelial barrier function","description":"Top terms converge on vascular and cardiovascular development: Notch signaling modulation, sprouting angiogenesis, aortic valve morphogenesis, blood-brain barrier maintenance, and blood coagulation all point to endothelial/vessel formation and barrier integrity. A few terms relate to broad developmental processes (blastocyst formation, polyspermy prevention) but do not override the vascular theme. ","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045746","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0034394","count":3},{"id":"GO:0007596","count":2}]},{"hash":"1868947321732214696","title":"TLR-driven innate immune activation","description":"This cluster centers on toll-like receptor signaling (TLR9 and TLR13), detection of lipopolysaccharide, and downstream inflammatory processes such as chemokine production, nitric oxide biosynthesis, and JNK signaling, indicating a cohesive group of proteins involved in innate immune sensing and response to bacterial components. The presence of a development term like male gonad development is likely incidental and not reflective of the core function of the cluster.","confidence":"High","size":17,"edges":18,"triangles":0,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0034162","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0045429","count":5},{"id":"GO:0090197","count":5}]},{"hash":"1626093844319298768","title":"Nucleocytoplasmic transport and RNA export","description":"The top GO terms are dominated by nuclear import, nuclear pore organization, and mRNA export in response to heat stress, pointing to a core function in nucleocytoplasmic transport and RNA trafficking among the proteins in this cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0060188","count":1},{"id":"GO:0072417","count":1},{"id":"GO:0031990","count":1}]},{"hash":"69067283591302417","title":"C-type lectin signaling and leukocyte activation","description":"The top GO terms show a strong focus on innate immunity, including stimulatory C-type lectin receptor signaling, phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and NK cell chemotaxis regulation, all pointing to C-type lectin\u2013driven immune responses and leukocyte activation. A few developmental terms appear (cartilage condensation, nephrogenic morphogenesis) which may be incidental noise rather than defining features of the cluster. Overall, the cluster is best described as an innate immune and leukocyte activation module centered on C-type lectin signaling.","confidence":"High","size":17,"edges":113,"triangles":449,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":14},{"id":"GO:0001502","count":13},{"id":"GO:0006910","count":13},{"id":"GO:0010572","count":13},{"id":"GO:0045575","count":13}]},{"hash":"1448688782241424568","title":"Stress-Response Cell Cycle and Apoptosis Regulation","description":"The cluster centers on mitotic cell cycle, DNA replication, apoptotic processes, and proteasomal protein degradation, with links to nuclear export and transcription factor regulation. Together these terms point to a module coordinating cell cycle control, quality control via proteolysis, and stress-induced apoptosis (e.g., cadmium exposure; ABA signaling), though some terms like angiogenesis are less cohesive. Confidence: Medium","confidence":"","size":17,"edges":15,"triangles":4,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046827","count":9},{"id":"GO:0043433","count":7},{"id":"GO:0071276","count":7},{"id":"GO:0032436","count":7},{"id":"GO:0000278","count":7}]},{"hash":"1839137538771356816","title":"Unknown","description":"The top GO terms span disparate areas (endothelial chemotaxis, male gonad development, GTPase regulation, stress response, ribosomal RNA maturation, histone modification, and even symbiont dormancy), with no clear, cohesive function linking all proteins. A single intuitive label isn\u2019t supported by the data.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035767","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0043547","count":3},{"id":"GO:1904643","count":3}]},{"hash":"2251464491918988012","title":"Platelet Activation and Coagulation Signaling","description":"The top GO terms cluster around platelet activation, blood coagulation, vasoconstriction, and calcium release, with related signaling pathways (ERK cascade, serotonin/dopamine signaling, opsin signaling) and even an immune response to LPS. This suggests a coherent theme of platelet-driven coagulation and vascular signaling with modulatory neuroendocrine cues.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0032496","count":7},{"id":"GO:0030168","count":7},{"id":"GO:0045907","count":7}]},{"hash":"2208402536584015378","title":"Innate Antiviral Immunity and Autophagy","description":"These proteins are enriched for antiviral defense and innate immune processes, notably defense response to virus and innate immune response, along with autophagy. The presence of NF-kappaB signaling regulation terms supports a role in immune signaling control related to antiviral responses, making this cluster best described as an innate antiviral immunity and autophagy module.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051607","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0051092","count":10},{"id":"GO:0043123","count":10},{"id":"GO:0006914","count":8}]},{"hash":"1364712099513650574","title":"Mitochondrial Apoptosis and Dynamics","description":"The top GO terms cluster around mitochondrial outer membrane permeabilization, apoptotic signaling, and mitochondrial fusion/fission, with regulation of membrane potential and general apoptotic processes. While a few terms touch on endocytosis or development, the dominant signal is mitochondrial involvement in apoptosis and morphology, justifying a label focused on mitochondrial apoptosis and dynamics.","confidence":"Medium","size":17,"edges":13,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0072583","count":2},{"id":"GO:1901030","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0070584","count":2}]},{"hash":"842506072488434230","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0046835","count":3},{"id":"GO:0006189","count":2},{"id":"GO:0006541","count":2},{"id":"GO:0007420","count":2}]},{"hash":"2163722875448020315","title":"Nucleobase and purine transport","description":"Most of the top GO terms describe import/transport of nucleobases and related metabolites (guanine, adenine, uracil, hypoxanthine, xanthine, urate) across the plasma membrane, indicating a common function as nucleobase/purine transporters. The presence of some obsolete terms doesn't change the core theme, while the TNF production term appears incidental. Thus, the cluster likely represents nucleobase and purine transport activity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098710","count":2},{"id":"GO:0098721","count":2},{"id":"GO:0035344","count":2},{"id":"GO:0042906","count":2},{"id":"GO:1903825","count":2}]},{"hash":"199068433299656283","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":8},{"id":"GO:2000637","count":8},{"id":"GO:0061158","count":8},{"id":"GO:1902187","count":8},{"id":"GO:0018032","count":7}]},{"hash":"2096150028001452052","title":"Unknown","description":"Top GO terms span diverse, unrelated metabolic processes (multiple catabolic pathways and vitamin biosynthesis) plus cell wall remodeling and an outlier development term, with no evident shared pathway or interactions. This lack of cohesive functional theme justifies an Unknown label.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":2},{"id":"GO:0019394","count":2},{"id":"GO:0034194","count":2},{"id":"GO:0009063","count":2},{"id":"GO:0019596","count":2}]},{"hash":"543845398633152788","title":"Ubiquitin-Dependent Proteostasis and Autophagy","description":"The top GO terms converge on ubiquitin-dependent protein catabolic processes and autophagy, including ubiquitin-dependent degradation and autoubiquitination. Additional terms hint at circadian rhythm regulation and immune signaling (TNF and IL-17 pathways), suggesting a broader role in stress response and inflammation. Together these indicate a proteostasis-focused cluster whose members coordinate protein turnover with autophagic pathways and cross-talk to immune and circadian signaling. Despite some obsolete terms, the core theme appears coherent: proteostasis and its regulation under stress conditions.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0042752","count":5},{"id":"GO:1901253","count":5},{"id":"GO:1903265","count":5},{"id":"GO:1903762","count":5}]},{"hash":"1447246192146784233","title":"Unknown","description":"The GO terms span inflammatory signaling, iron/metabolite transport, endocytosis and proteolysis, bone resorption, and distinct plant development processes, with no single cohesive function linking all proteins. This makes a concise, representative label impractical.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":4},{"id":"GO:0033572","count":3},{"id":"GO:0045830","count":3},{"id":"GO:0010103","count":3},{"id":"GO:1904382","count":3}]},{"hash":"1824699515043272876","title":"Unknown","description":"The top terms span coagulation and complement activation, various developmental processes (endoderm differentiation, eye morphogenesis), transcriptional regulation, and signaling/neuronal maintenance, with no single cohesive function dominating. Therefore there isn\u2019t a clear, representative label for this cluster.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0006351","count":3},{"id":"GO:2000860","count":2}]},{"hash":"2148394380280982842","title":"Calcium signaling in sensory, thermogenic, and visual processes","description":"These terms converge on calcium release into the cytosol and its regulation, repeatedly tied to sensory (pain), temperature/thermogenic responses, and vision (phototransduction, visual learning). The presence of ERK1/ERK2 cascade regulation and IL-1 beta production hints at broader signaling integration, suggesting a cohesive theme of calcium-dependent signaling coordinating sensory, thermogenic, and visual processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0051281","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0071502","count":5}]},{"hash":"2141372847309323738","title":"Toll-like Receptor Signaling Cluster","description":"The top GO terms are dominated by Toll-like receptor signaling pathways (TLR3, TLR7, TLR9), suggesting a cohesive innate immune signaling theme. Other terms touch on development and apoptosis (axonogenesis, skeletal muscle differentiation, mitochondrial membrane permeability regulation), which may reflect multifunctional proteins or downstream cross-talk. Overall, the cluster appears centered on immune signaling with some developmental/apoptotic associations.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034138","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0034162","count":2},{"id":"GO:0034154","count":2},{"id":"GO:0007409","count":2}]},{"hash":"1372265425082350075","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are dominated by ribosome biogenesis, cytoplasmic translation, tRNA modification, and ribosomal subunit export from the nucleus, indicating a cluster of proteins involved in ribosome assembly and use for protein synthesis. There are also cell cycle/division terms, reflecting the link between ribosome production and cell proliferation. A few stress-response terms appear, but they seem less central to the main theme. Overall, this cluster centers on ribosome-related biogenesis and translation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007049","count":9},{"id":"GO:0051301","count":6},{"id":"GO:1901001","count":6},{"id":"GO:0000747","count":6},{"id":"GO:0042274","count":6}]},{"hash":"1722037211605533985","title":"Lipid signaling and adipogenesis","description":"The cluster shows enrichment for fat cell differentiation and vitamin D response, pointing to adipocyte biology and lipid-related signaling. Additional terms like intracellular signal transduction, calcium ion release, and glycerophospholipid catabolic processes suggest coordinated signaling and membrane lipid remodeling relevant to adipogenesis. Because these terms collectively center on lipid signaling and adipocyte formation rather than a single precise pathway, a label focused on lipid signaling and adipogenesis seems most representative.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":7},{"id":"GO:0042787","count":6},{"id":"GO:0045444","count":6},{"id":"GO:0035556","count":6},{"id":"GO:0051209","count":5}]},{"hash":"2361834113810282","title":"Nucleobase Transport Across Plasma Membrane","description":"The proteins show a strong enrichment for import/transport of adenine, guanine, uracil, hypoxanthine, xanthine, and urate across the plasma membrane, indicating a shared role as nucleobase/purine transporters; ancillary terms about antibiotic response and ubiquitin-dependent protein catabolism appear ancillary to this core function.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098710","count":2},{"id":"GO:0098721","count":2},{"id":"GO:0035344","count":2},{"id":"GO:0042906","count":2},{"id":"GO:1903825","count":2}]},{"hash":"100872744991836742","title":"NF-kB and TLR signaling regulation","description":"The cluster is enriched for GO terms tied to immune/inflammatory signaling and cell fate control, notably positive regulation of canonical NF-kappaB signaling, regulation of Toll-like receptor signaling, and processes affecting apoptosis, necroptosis, and calcium signaling. This pattern suggests a theme around immune signaling pathways and how they govern cell survival and death.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0043066","count":5},{"id":"GO:0000209","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0043123","count":4}]},{"hash":"135392144840665642","title":"Immune modulation and coagulation","description":"The GO terms cluster around T cell activation and costimulation, regulation of inflammatory mediators (negative IL-6, positive IL-10), and pathways linking growth factor signaling, platelet activation, and blood coagulation, with additional signals from JNK cascade and osteoclast differentiation. Together they suggest a theme of coordinated immune responses with hemostasis and potential bone-immune interactions; note that one term (trophoblast giant cell differentiation) may reflect shared signaling nodes rather than a placenta-specific process.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0032715","count":3},{"id":"GO:0032733","count":3},{"id":"GO:0048012","count":3},{"id":"GO:0007596","count":3}]},{"hash":"103766527067402011","title":"Lipid signaling in reproduction and circadian rhythms","description":"These GO terms cluster around lipid metabolism and signaling (lipid catabolic process, phospholipid metabolic process, arachidonate secretion, lipoxygenase pathway) as well as reproductive biology (acrosome assembly, sperm axoneme assembly) and circadian rhythm-related terms (rhythmic process, regulation of circadian sleep/wake cycle). The common thread appears to be lipid-mediated signaling influencing both sperm-related functions and circadian regulation, so the label emphasizes lipid signaling with reproductive and rhythmic contexts.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016042","count":1},{"id":"GO:0019372","count":1},{"id":"GO:0001675","count":1},{"id":"GO:0043303","count":1},{"id":"GO:0007288","count":1}]},{"hash":"673797759490371795","title":"Autophagy-regulating proteins","description":"This cluster centers on autophagy (GO:0006914) and includes several regulatory terms that modulate protein turnover, epigenetic programming, and immune-related processes (e.g., MHC class I biosynthesis), plus negative regulation of various cellular pathways. The mix suggests a group of proteins that coordinate autophagy with broader cellular regulation, rather than a single, narrowly defined function. Confidence reflects the central autophagy signal but acknowledges diverse regulatory associations. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":9},{"id":"GO:1900458","count":9},{"id":"GO:2000059","count":9},{"id":"GO:0060669","count":9},{"id":"GO:1901536","count":9}]},{"hash":"152581722578371406","title":"Immune signaling and RNA regulation","description":"The terms indicate a mix of immune signaling regulation (IL-17 and TNF pathways), RNA-based control (miRNA metabolism and silencing), and broader regulatory processes (apoptosis, GTPase activity, ubiquitination, and peptide modification). This suggests a cluster of proteins broadly involved in modulating immune responses and gene expression rather than a single, cohesive pathway, hence a broad but representative label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072089","count":2},{"id":"GO:0010586","count":2},{"id":"GO:1903883","count":2},{"id":"GO:0001519","count":2},{"id":"GO:1903265","count":2}]},{"hash":"951698905150740838","title":"ER protein folding and ERAD quality control","description":"The cluster\u2019s dominant GO terms center on endoplasmic reticulum processes: protein folding in the ER, ER-associated degradation (ERAD), and ubiquitin-proteasome\u2013mediated protein quality control, with redox homeostasis and hypoxia as contextual stress responses. This suggests a cohesive group of proteins involved in ER maturation and subsequent degradation of misfolded proteins, rather than disparate cellular roles. Translational frameshifting and tRNA import may reflect broader stress-linked regulation but are less central to the core theme.","confidence":"High","size":16,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0097428","count":2},{"id":"GO:0006452","count":2},{"id":"GO:0034975","count":2}]},{"hash":"603434213406361883","title":"Osteoclast Actin Remodeling and Adhesion Signaling","description":"The top GO terms point to small GTPase\u2013mediated signaling, actin cytoskeleton reorganization, podosome and filopodium assembly, and adherens junction organization, all of which are central to osteoclast development and their dynamic cytoskeletal/adhesive structures. This cluster appears to capture proteins coordinating signaling with actin-based adhesion structures essential for osteoclast function.","confidence":"High","size":16,"edges":92,"triangles":282,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007264","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0036035","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0006626","count":4}]},{"hash":"412777342470736699","title":"Embryonic organogenesis","description":"This cluster is enriched for terms describing development and morphogenesis of multiple embryonic organs (eye/retina, osteoblast-containing tissues, digestive tract, pancreas) and includes transcriptional regulation steps, suggesting a shared role in orchestrating embryonic organ formation.","confidence":"High","size":16,"edges":73,"triangles":140,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002076","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0002087","count":5},{"id":"GO:0060041","count":5},{"id":"GO:0006351","count":4}]},{"hash":"1605877051252380049","title":"Transmembrane nutrient and xenobiotic transport","description":"The cluster\u2019s GO terms cluster around moving small molecules across membranes: vitamins, xenobiotics, sugars (glucose, fructose, trehalose), and ions (potassium), with an osmotic stress response. This points to a cohesive theme of membrane transporters handling diverse solutes and osmotic challenges.","confidence":"High","size":16,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":15},{"id":"GO:0006855","count":15},{"id":"GO:0042908","count":14},{"id":"GO:0071805","count":13},{"id":"GO:0042891","count":11}]},{"hash":"1255446066367146558","title":"Osteoclastogenesis and cytoskeletal signaling","description":"Top GO terms point to osteoclast development, podosome/actin cytoskeleton remodeling, and signaling pathways (small GTPases, ephrin, and Wnt) coordinating cell adhesion, calcium signaling, and protein turnover. The cluster appears to represent proteins involved in osteoclast differentiation and the cytoskeletal dynamics essential for bone resorption, with ubiquitination regulating component turnover.","confidence":"High","size":16,"edges":64,"triangles":92,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":4},{"id":"GO:0034332","count":4},{"id":"GO:0071803","count":4},{"id":"GO:0051281","count":4},{"id":"GO:0016567","count":4}]},{"hash":"1389436910788990690","title":"Neural ion channels and synaptic endocytosis","description":"This cluster centers on ion transmembrane transport (K+, Na+) and clathrin-dependent endocytosis, with accompanying neural signaling terms (serotonin/dopamine pathways) and sensory system development notes. The combination suggests a theme of neuronal excitability and synaptic vesicle cycling, making the label representative of the cluster\u2019s function.","confidence":"Medium","size":16,"edges":8,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0072583","count":2},{"id":"GO:1901407","count":2}]},{"hash":"335062681893956866","title":"Actin dynamics with mRNA processing in cell migration","description":"The cluster combines strong signals for actin-related remodeling (stress fiber and filopodium assembly) and cell movement (fibroblast migration, axon guidance) with RNA metabolism and translational control (P-body assembly, deadenylation-dependent decapping, regulation of translational initiation). This suggests a coordinated module where cytoskeletal dynamics and local mRNA processing regulate migratory behavior, possibly involving Golgi-associated trafficking. ","confidence":"Medium","size":16,"edges":30,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051496","count":2},{"id":"GO:0000042","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0007411","count":2},{"id":"GO:1900363","count":2}]},{"hash":"455621853036541258","title":"Neural development and cell-cycle/DNA processes","description":"The top GO terms combine clear neural development signals (nervous system development, dendrite morphogenesis, neural tube closure, multicellular organism development) with core cell-cycle and DNA-maintenance activities (mitotic cell cycle, DNA replication, DNA repair, DNA-templated transcription, apoptosis). This suggests proteins involved in neural development that also coordinate proliferation and genome maintenance during development. While an immune signaling term appears, the dominant theme is neurodevelopment linked with proliferative/DNA-related processes, justifying this label.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":14},{"id":"GO:0006260","count":13},{"id":"GO:0007399","count":12},{"id":"GO:0048813","count":12},{"id":"GO:0050852","count":12}]},{"hash":"899766879005833228","title":"Ribosome maturation and mitochondrial translation","description":"The Top Terms include maturation of 5.8S and LSU rRNA (ribosome biogenesis), translation and translational elongation, and maintenance of translational fidelity, indicating a core role in ribosome assembly and protein synthesis. Additional terms point to mitochondrial quality control (regulated autophagy) and stress response (cellular response to ionizing radiation), suggesting linked mitochondrial maintenance. A couple of terms such as angiogenesis and actin regulation are less directly related and may reflect broader cellular processes or noise.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":1},{"id":"GO:0000463","count":1},{"id":"GO:1903955","count":1},{"id":"GO:1903146","count":1},{"id":"GO:0006412","count":1}]},{"hash":"545804298860552836","title":"Membrane transporters for ions and nutrients","description":"The cluster\u2019s top GO terms are all related to transmembrane transport of diverse substrates, including ions (potassium, sodium), sugars (galactose, arabinose), nitrate/nitrite, sialic acid, vitamins, and other small molecules. This points to a cohesive function as membrane transport proteins handling a variety of substrates, rather than a single substrate or non-transport role. Therefore, the name reflects the shared function across the cluster.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0015757","count":4},{"id":"GO:0015706","count":4},{"id":"GO:0015707","count":4},{"id":"GO:0015751","count":4}]},{"hash":"2163689284727254750","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":107,"triangles":406,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":10},{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0006369","count":7},{"id":"GO:0000463","count":6}]},{"hash":"548084611904126927","title":"Inflammation, Temperature, and Vascular Signaling","description":"This cluster is enriched for terms tying thermal and pain responses (cellular response to temperature stimulus, sensory perception of pain, diet-induced thermogenesis) with inflammatory and vascular processes (regulation of IL-1\u03b2, prostaglandin response, calcium release, blood coagulation, and vascular smooth muscle differentiation). The mix suggests a shared theme of stress-induced inflammation and vascular signaling, though the exact connections are varied, so the label is moderately confident.","confidence":"Medium","size":16,"edges":8,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0018298","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0042391","count":16},{"id":"GO:0019233","count":16},{"id":"GO:0071502","count":16}]},{"hash":"2096640634935100699","title":"Neuronal axon guidance and adhesion signaling","description":"The top GO terms cluster around neuronal development: dopaminergic and serotonergic axon guidance, GPCR-mediated acetylcholine signaling, receptor clustering, and both homophilic and heterophilic cell-cell adhesion. These together point to signaling and adhesion events guiding axon pathfinding in neurons. A few terms about broader development (lung morphogenesis, brown fat differentiation) are present but do not override the central neuronal guidance theme. Confidence: High","confidence":"","size":16,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061097","count":4},{"id":"GO:0043113","count":3},{"id":"GO:0007213","count":3},{"id":"GO:0050873","count":3},{"id":"GO:0060489","count":3}]},{"hash":"1091246613292339722","title":"Leukocyte adhesion and complement activation","description":"This cluster is dominated by GO terms tied to immune cell interactions and innate responses: leukocyte tethering/rolling, basophil and platelet activation, phagocytosis recognition, and complement activation via the lectin pathway. While a couple of terms pertain to development (cartilage condensation, kidney morphogenesis) they seem peripheral to the main signal. Overall, the proteins likely participate in leukocyte recruitment and innate immune activation.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0071226","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0060355","count":4},{"id":"GO:0051873","count":4}]},{"hash":"2188324432310895950","title":"Unknown","description":"The terms span autophagy, ubiquitin-dependent protein catabolism, miRNA metabolism, epigenetic regulation, development (placenta morphogenesis, stem cell proliferation), and antiviral/immune signaling, with no single dominant function linking all proteins, and the network shows no edges, so a cohesive label is not supported.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":3},{"id":"GO:1900458","count":3},{"id":"GO:0072089","count":3},{"id":"GO:2000059","count":3},{"id":"GO:0060669","count":3}]},{"hash":"1886013469827184681","title":"Cytoskeletal signaling in development","description":"Top GO terms cluster around signaling (cellular response to transforming growth factor beta stimulus), cytoskeletal dynamics (microtubule-based movement, mitotic spindle assembly) and protein interactions (homooligomerization, heterotrimerization, GTPase regulation). Developmental terms (spinal cord development) support a developmental context. Immune-related terms may be incidental. Overall, the cluster appears to reflect proteins coordinating signaling with cytoskeletal remodeling during development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071560","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0090307","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0021510","count":3}]},{"hash":"197123821621638506","title":"Unknown","description":"The top GO terms span immune defense (complement activation lectin pathway; defense response to Gram-positive bacterium), protein turnover (ubiquitin-dependent proteolysis), secretion regulation, cell cycle, and various stress responses (cadmium, oxidative stress-induced neuronal apoptosis). There is no single unifying function linking these terms, and the cluster has no edges or apparent connectivity, making a coherent, specific label inappropriate. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050714","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0042787","count":3}]},{"hash":"1720080741191528214","title":"Inflammation and vascular signaling","description":"These terms cluster around inflammatory signaling (regulation of IL-1\u03b2 production, prostaglandin response), calcium signaling (calcium release into cytosol), and vascular processes (blood coagulation, vascular smooth muscle differentiation), suggesting a group of proteins involved in immune-to-vascular communication and coagulation pathways. Some terms like grooming behavior and phototransduction may reflect broader or pleiotropic annotations. Overall, the cluster appears to represent inflammation- and vascular-related signaling. ","confidence":"Medium","size":16,"edges":10,"triangles":2,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":8},{"id":"GO:0051209","count":8},{"id":"GO:0071380","count":8},{"id":"GO:0007596","count":8},{"id":"GO:2000724","count":8}]},{"hash":"1429772869253831242","title":"Heart development and cell cycle regulation","description":"The top terms include heart development and anterior/posterior pattern specification, pointing to developmental patterning roles. Also present are terms for G1/S transition, DNA replication, and cell cycle, suggesting a link to proliferation during development. Additional terms on peptidyl-tyrosine phosphorylation and adhesion-dependent spreading indicate coordinated signaling and cell interactions during development. Overall, the cluster appears tied to heart development with concurrent cell cycle control. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009952","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0050731","count":2},{"id":"GO:1900087","count":1}]},{"hash":"624161286522618588","title":"Mitotic Ubiquitination and Proteasomal Degradation","description":"Top GO terms indicate heavy involvement in ubiquitin-proteasome\u2013mediated protein turnover, especially SCF- and APC/C-dependent degradation, with K11- and K48-linked ubiquitination, ERAD components, and neddylation, all linked to mitotic progression and DNA damage checkpoints. This suggests a cohesive role in regulating mitosis through targeted proteolysis.","confidence":"High","size":16,"edges":49,"triangles":59,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":8},{"id":"GO:0070979","count":8},{"id":"GO:0051301","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0031145","count":7}]},{"hash":"891470533641390654","title":"Organ morphogenesis and neural development","description":"The top GO terms cluster around tissue and organ formation (valve formation, coronary morphogenesis, lung branching morphogenesis) and neural development processes (axon extension, synapse assembly, locomotory and sensory specialization). This mix suggests proteins involved in broad developmental programs across multiple organs, with a clear neural development component, rather than a single, specific pathway. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0060982","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0048846","count":4}]},{"hash":"1516625445370765381","title":"Mitochondrial electron transport and flavin biosynthesis","description":"This cluster shows strong enrichment for mitochondrial processes: mitochondrial electron transport (cytochrome c to oxygen), protein import into the mitochondrial matrix, and assembly of respiratory chain complex IV, indicating a role in mitochondrial respiration. Additionally, terms for FAD, FMN, and riboflavin biosynthesis point to flavin cofactor production essential for flavoproteins in the respiratory chain. Other terms like protein folding and phosphorylation may reflect ancillary chaperone or regulatory roles, but the dominant theme is mitochondrial energy metabolism and cofactor biosynthesis.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":3},{"id":"GO:0030150","count":3},{"id":"GO:0033617","count":2},{"id":"GO:0050790","count":2},{"id":"GO:0006457","count":2}]},{"hash":"1948994923109954045","title":"Angiogenesis and heart development","description":"This cluster centers on vascular formation and heart biology, with supporting terms for cell adhesion and mechanotransduction, plus fibrinolysis and platelet regulation, indicating a cardiovascular development/remodeling theme. Some terms like lens fiber differentiation and extrinsic apoptotic signaling are peripheral, but do not negate the dominant vascular/heart development signal.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1902042","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0007155","count":4},{"id":"GO:0051092","count":3}]},{"hash":"488002029080973859","title":"Lectin receptor\u2013driven innate immune activation","description":"The cluster is dominated by immune-related GO terms, including stimulatory C-type lectin receptor signaling, phagocytosis recognition, basophil activation, leukocyte tethering/rolling, and regulation of NK cell chemotaxis, pointing to a theme of lectin-mediated innate immune activation and leukocyte recruitment. Some developmental terms (cartilage condensation, mesonephric duct/metanephric morphogenesis) likely reflect broader annotation overlap and are less indicative of the core function.","confidence":"High","size":16,"edges":37,"triangles":21,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002223","count":14},{"id":"GO:0001502","count":13},{"id":"GO:0006910","count":13},{"id":"GO:0010572","count":13},{"id":"GO:0045575","count":13}]},{"hash":"1119972874273672274","title":"ER Stress and Protein Folding","description":"The most represented GO terms cluster around protein folding and ER-related quality control\u2014chaperone-assisted refolding, unfolded protein response, and SRP-dependent translocation to the ER. These points together with stress-related apoptotic regulation suggest the cluster chiefly reflects ER stress response and protein quality control.","confidence":"High","size":16,"edges":100,"triangles":325,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":7},{"id":"GO:0006260","count":7},{"id":"GO:0090084","count":6},{"id":"GO:1903382","count":6},{"id":"GO:0006880","count":6}]},{"hash":"7520737509366078","title":"Unknown","description":"The terms mix autophagy, ubiquitin-mediated proteolysis, immune signaling (NF-kappaB, IL-17), and diverse development-related processes (stem cell proliferation, placenta morphogenesis, miRNA metabolism), with some plant-specific terms. There isn\u2019t a single coherent function that ties these proteins together, suggesting heterogeneous roles or annotation noise rather than a defined pathway. Therefore, no precise, representative label can be assigned beyond Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:0006914","count":5},{"id":"GO:1900458","count":5},{"id":"GO:0072089","count":5},{"id":"GO:2000059","count":5}]},{"hash":"555715625765869507","title":"Ubiquitination and Autophagy Regulation","description":"Top GO terms highlight negative regulation of ubiquitin-dependent protein catabolic processes, K63-linked ubiquitination, and autoubiquitination, together with autophagy. Additional terms touch on epigenetic programming and signaling regulation, but the core group centers on ubiquitin signaling and autophagy control proteins. This combination suggests a functional cluster focused on the interplay between ubiquitination and autophagy.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:2000059","count":8},{"id":"GO:0060669","count":8},{"id":"GO:0070534","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0006914","count":7}]},{"hash":"28156723857686914","title":"Autophagy and Epigenetic Immune Regulation","description":"The top GO terms center on autophagy and linked processes (epigenetic programming, regulation of ubiquitin-dependent proteolysis, DNA demethylation), with immune-related terms such as MHC class I biosynthesis and antiviral regulation, and a developmental context (placental morphogenesis). This pattern suggests a coherent theme where autophagy intersects with epigenetic control and immune function, including antigen presentation and antiviral defenses, across development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":7},{"id":"GO:1900458","count":7},{"id":"GO:2000059","count":7},{"id":"GO:0060669","count":7},{"id":"GO:1901536","count":7}]},{"hash":"2092561267938748031","title":"Autophagy and proteostasis regulation","description":"The top terms are heavily dominated by autophagy (GO:0006914) and the negative regulation of ubiquitin-dependent protein catabolic processes, indicating a core focus on cellular quality control and protein turnover. Additional signals from RNA metabolism and epigenetic regulation further support a broader regulatory theme governing gene expression under stress, with other developmental and immune annotations likely reflecting broader regulatory roles. Overall, labeling this cluster as autophagy and proteostasis regulation captures the most representative shared function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":14},{"id":"GO:1900458","count":14},{"id":"GO:0072089","count":14},{"id":"GO:2000059","count":14},{"id":"GO:0060669","count":14}]},{"hash":"2141600267732041145","title":"Endothelial migration and angiogenesis regulation","description":"The cluster is dominated by GO terms tied to endothelial cell movement and blood vessel formation, including positive regulation of endothelial cell migration, negative regulation of angiogenesis, and related signaling such as ERK cascade, plus cell-matrix adhesion. While oxidative detoxification and some miscellaneous processes appear, the core motif is vascular endothelial dynamics and angiogenic control.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0043536","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0016525","count":3}]},{"hash":"278842313036922650","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0090262","count":2},{"id":"GO:2001209","count":2},{"id":"GO:0032968","count":2}]},{"hash":"1593773127001072885","title":"GCN2-Driven Starvation Response","description":"The top GO terms point to amino acid starvation signaling and translational control, notably GCN2-mediated signaling and positive regulation of translational initiation in response to starvation, along with related stress responses (UV-C, hydrogen peroxide) and ribosome biogenesis. While there are some development-related terms, the strongest and most recurrent theme is the integrated stress response centered on translation regulation during nutrient deprivation, justifying this label as representative of the cluster\u2019s function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060733","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0051301","count":2}]},{"hash":"647326349756714610","title":"Prostaglandin-driven lipid signaling and reproductive development","description":"The top GO terms are centered on prostaglandin biosynthesis, eye vascular development, and reproductive processes (sex differentiation, maternal parturition), suggesting a theme of prostaglandin-related signaling connected to development and reproduction. Additional terms about epoxygenase P450 and xenobiotic metabolism point to broader lipid metabolism and detoxification contexts, but prostaglandin pathways and reproductive development appear to be the core theme of this cluster.","confidence":"Medium","size":16,"edges":5,"triangles":1,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0001516","count":5},{"id":"GO:0061298","count":5},{"id":"GO:0035865","count":4},{"id":"GO:1900087","count":4},{"id":"GO:0033072","count":4}]},{"hash":"336787302861723366","title":"Innate immune activation and leukocyte recruitment","description":"This cluster is strongly enriched for immune-related terms: complement activation (lectin pathway), phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and regulation of NK cell chemotaxis, pointing to innate immune activation and leukocyte\u2013endothelium interactions. Some developmental terms appear, but the dominant signal is immune response and leukocyte recruitment.","confidence":"High","size":16,"edges":100,"triangles":381,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":13},{"id":"GO:0001502","count":11},{"id":"GO:0006910","count":11},{"id":"GO:0010572","count":11},{"id":"GO:0045575","count":11}]},{"hash":"34157382655030227","title":"Regulators of signal transduction","description":"The top GO terms point to multiple negative regulatory roles in signaling pathways (BMP signaling, calcium signaling, peptidyl-tyrosine phosphorylation) and GPCR-mediated signaling, plus receptor clustering. Although there are a few developmental terms (embryo implantation, spermatogenesis, dendritic spine development), the common thread is regulation and modulation of signal transduction and receptor organization, rather than a single cohesive pathway. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0007566","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0050732","count":2}]},{"hash":"454379644637812031","title":"Cardiac GPCR-cAMP signaling and heart development","description":"Based on the top GO terms, the cluster centers on GPCR signaling that activates adenylate cyclase and increases cAMP, which is a key pathway in cardiac signaling, together with regulation of cardiac muscle contraction, heart development, and blood pressure control. The presence of related terms like protein phosphorylation and opsin-mediated signaling supports a broader GPCR/cAMP influence in heart-related functions. The electron transport chain term is less central to this theme but may reflect mitochondrial energy in cardiac cells.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":10},{"id":"GO:0010579","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0045777","count":9},{"id":"GO:0022400","count":8}]},{"hash":"1472004050475106196","title":"Unknown","description":"The top GO terms are diverse, spanning symbiont dormancy in a host, general stress response, lipid catabolism, neuronal signaling (excitatory postsynaptic potential and its regulation), DNA replication, calcium release, and other unrelated processes. This lack of a single cohesive function or pathway linking the proteins suggests there is no clear common theme for the cluster; thus an Unknown label with no confidence is appropriate.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":5},{"id":"GO:0006950","count":5},{"id":"GO:0046475","count":3},{"id":"GO:0060079","count":2},{"id":"GO:0090394","count":2}]},{"hash":"632423632189191697","title":"Leukocyte recruitment and activation","description":"The top GO terms are dominated by immune-related processes: leukocyte tethering/rolling, phagocytosis recognition, basophil activation, NK cell chemotaxis regulation, and cellular responses to fungal molecules, plus inflammatory mediators like arachidonate secretion and platelet activation. Together these point to a cluster of proteins involved in initiating and modulating immune cell trafficking and activation during inflammation, with some developmental terms present likely due to shared signaling pathways.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":16},{"id":"GO:0006910","count":16},{"id":"GO:0010572","count":16},{"id":"GO:0045575","count":16},{"id":"GO:0050901","count":16}]},{"hash":"1053129568258257063","title":"Fatty acid metabolism","description":"The top GO terms are dominated by fatty acid biosynthesis, long- and medium-chain acyl-CoA synthesis, and beta-oxidation/catabolic processes, indicating the proteins in this cluster are mainly involved in fatty acid metabolic pathways and acyl-CoA turnover. Some terms are regulatory or unrelated (e.g., enterobactin biosynthesis), but the prevailing theme is lipid metabolism.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009239","count":1},{"id":"GO:0045892","count":1},{"id":"GO:0010124","count":1},{"id":"GO:1900535","count":1},{"id":"GO:0045717","count":1}]},{"hash":"1915880868663606059","title":"Melanocyte migration and skin patterning","description":"This cluster is highlighted by terms tied to melanocyte biology, including migration and adhesion, as well as planar cell polarity and skin-related development. While there are a few immune-related terms present (innate response and IL-12 signaling), the dominant signals center on pigment cell development and skin patterning, with planar polarity contributing to proper tissue organization. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001501","count":7},{"id":"GO:0014068","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0042517","count":6},{"id":"GO:0002318","count":6}]},{"hash":"314581071032455003","title":"Neuroimmune Signaling and Pain Response","description":"Top GO terms indicate a core immune response (innate immunity, cellular response to lipopolysaccharide, defense against Gram-positive bacteria, interferon-beta production) alongside neural-related terms (axonogenesis, corpus callosum development, dopamine response) and a pain-related behavior term. The combination suggests a module where immune signaling intersects neural development and nociception, i.e., a neuroimmune/pain-associated cluster rather than a purely immune or purely neural set.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0045359","count":3},{"id":"GO:1903351","count":3}]},{"hash":"1343359796219690179","title":"ECM remodeling and vascular regulation","description":"The cluster\u2019s top GO terms point to extracellular matrix organization and remodeling (elastic fiber assembly, cell-matrix adhesion), along with vascular processes (vasoconstriction, angiogenesis) and proteolytic activity (plasminogen activation) plus coagulation. These together suggest a cohesive theme around extracellular matrix\u2013mediated structural remodeling and vascular regulation, with some immune and neural terms present as peripheral associations. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0034394","count":3},{"id":"GO:0072378","count":3}]},{"hash":"1863849204458540894","title":"Angiogenesis Regulators in Embryonic Development","description":"This cluster centers on regulation of blood vessel formation and related developmental signaling. The top GO terms cluster around angiogenesis (positive and negative regulation), VEGF signaling modulation, BMP response, and embryonic development processes (in utero development, bronchial epithelium development). Additional terms for nitric oxide signaling regulation and TNF production hint at coordinated vascular-immune development. Overall, the proteins likely function as a developmental module coordinating vascular formation and signaling during embryogenesis rather than a single specialized pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045766","count":6},{"id":"GO:0016525","count":6},{"id":"GO:0001701","count":5},{"id":"GO:1902548","count":5},{"id":"GO:0061743","count":5}]},{"hash":"1965799605655663069","title":"Ubiquitination Pathways and NF-\u03baB Signaling","description":"Top GO terms point to ubiquitin-dependent protein catabolic processes, multiple ubiquitin linkages (K6, K63, linear), autoubiquitination, and histone ubiquitination, plus positive regulation of canonical NF-\u03baB signaling and TNF-mediated pathways and suppression of necroptosis. This pattern indicates a cohesive set of proteins involved in ubiquitin-mediated protein turnover and chromatin modification that modulate inflammatory signaling, aligning the cluster around ubiquitination machinery and NF-\u03baB\u2013related regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0085020","count":7},{"id":"GO:1903265","count":7},{"id":"GO:0036205","count":7},{"id":"GO:0070534","count":7}]},{"hash":"1496985938247955262","title":"Embryonic and sensory organ morphogenesis","description":"The Top Terms include optic nerve morphogenesis, compound eye photoreceptor differentiation, sensory perception of sound, nephric duct morphogenesis, and pericyte differentiation, all pointing to development and shaping of sensory organs and other tissues during embryogenesis. While some terms (spindle assembly, forskolin response, poly-ADP-ribosylation) reflect general cellular processes, the overarching theme is morphogenesis and organ development, especially in sensory systems. Confident that this label captures the cluster\u2019s core function, with some additional cellular processes involved.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0001751","count":1},{"id":"GO:1904322","count":1}]},{"hash":"1069929953732856536","title":"Unknown","description":"The top GO terms are a mix of immune differentiation (dendritic cells, memory T cells), skeletal muscle development (tissue and fiber), kidney function, and some unrelated/obsolete terms, suggesting no single coherent function ties the proteins together. Because there isn\u2019t a clear, unified theme, the appropriate label is Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0043380","count":3},{"id":"GO:0007519","count":3},{"id":"GO:0070294","count":3},{"id":"GO:1900477","count":3}]},{"hash":"145357620484249839","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007014","count":9},{"id":"GO:2000637","count":9},{"id":"GO:0061158","count":9},{"id":"GO:1902187","count":9},{"id":"GO:0018032","count":7}]},{"hash":"141197892083856509","title":"Cellular maintenance and gene regulation","description":"The cluster centers on processes that preserve cellular integrity, including plasma membrane repair, autophagy, regulation of protein turnover, and epigenetic programming. While some terms are plant- or development-specific or obsolete, the shared theme is cellular homeostasis\u2014keeping membranes intact, controlling protein quality, and modulating gene expression.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0001778","count":5},{"id":"GO:0006914","count":4},{"id":"GO:1900458","count":4},{"id":"GO:2000059","count":4},{"id":"GO:0060669","count":4}]},{"hash":"569914659461463277","title":"Drosophila sensory organ morphogenesis and mitosis","description":"The top terms point to antennal morphogenesis, sensory organ precursor cell division, and mitotic processes (mitotic spindle assembly, regulation of cytokinesis), together suggesting a cluster tied to insect sensory organ development and associated cell division. While some terms are obsolete, the remaining non-obsolete terms support this cohesive theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0051311","count":1},{"id":"GO:1990001","count":1},{"id":"GO:0048800","count":1},{"id":"GO:0045035","count":1}]},{"hash":"1460962610560757202","title":"Endothelial immune-angiogenic signaling","description":"The top GO terms point to vascular biology and immune-related signaling: angiogenesis, endothelial cell migration, blood coagulation, vasoconstriction, IL-6 response, and cell-surface pattern-recognition receptor signaling, all indicating endothelial cells integrating inflammatory cues to regulate blood vessel formation and function. A peripheral term about transmission of nerve impulse is less central, so the core theme remains endothelial-immune-angiogenic signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034394","count":4},{"id":"GO:0051971","count":4},{"id":"GO:0045766","count":3},{"id":"GO:0002752","count":3},{"id":"GO:0001525","count":3}]},{"hash":"238186333844794663","title":"Cytoskeleton Dynamics and Adhesion","description":"The top GO terms cluster around cytoskeletal regulation and cell-matrix interactions, including negative regulation of microtubule depolymerization, actin filament-based transport, focal adhesion assembly, and tight junction assembly. While a few terms relate to specific developmental contexts (megakaryocyte development, vagus nerve development, proboscis morphogenesis), the dominant signal is cytoskeletal remodeling and adhesion-related processes, suggesting this cluster reflects cytoskeleton dynamics and cell\u2013matrix adhesion rather than a single specific pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007182","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0048041","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0070830","count":1}]},{"hash":"593894248336125790","title":"Proteoglycan and GAG Biosynthesis","description":"Proteins in this cluster are annotated with several glycosaminoglycan and proteoglycan biosynthetic terms, including chondroitin sulfate, dermatan sulfate, and heparan sulfate biosynthesis/modification, as well as proteoglycan biosynthetic processes. This points to a core theme of extracellular matrix assembly and proteoglycan production, with supporting signals from cell adhesion and developmental processes. Some terms are obsolete, but the conserved thread is proteoglycan/ECM biosynthesis and associated signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0015015","count":2},{"id":"GO:0007155","count":1}]},{"hash":"782826414663467585","title":"Unknown","description":"The GO terms span hormone signaling regulation, cell spreading, antibiotic biosynthesis, reproductive binding, protein folding, senescence, synaptic vesicle cycling, immune cell chemotaxis, ER stress responses, and MHC I antigen assembly. This broad, disparate mix lacks a single cohesive biological theme, making a specific, high-level cluster label unsupported.","confidence":"","size":15,"edges":48,"triangles":87,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0033144","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0007339","count":2},{"id":"GO:0006457","count":2}]},{"hash":"924648025691416064","title":"Neural signaling and sensory processing","description":"This cluster centers on neuronal signaling and sensory pathways, with terms for hearing (sensory perception of sound), vestibulocochlear nerve development, visual pathway development (lateral geniculate nucleus), and broad synaptic activity (membrane depolarization, cholinergic transmission) plus neuromodulation (serotonin signaling, dopamine secretion) and excitability (potassium transport). Together, they point to proteins involved in neural communication and sensory processing across modalities.","confidence":"High","size":15,"edges":37,"triangles":15,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0007210","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0033603","count":1},{"id":"GO:0001988","count":1}]},{"hash":"2008323037976450701","title":"Neuronal Secretory Trafficking","description":"This cluster shows neural-related terms (axonal fasciculation, visual perception) alongside intracellular trafficking and secretion processes (COPI vesicles, ER-to-Golgi transport, Wnt secretion), suggesting a shared theme of neural development driven by secretory pathway activity. Some terms are broader developmental processes, but the majority point to neuronal trafficking and protein secretion.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0048205","count":1},{"id":"GO:0035964","count":1},{"id":"GO:0032525","count":1}]},{"hash":"1218403710710730532","title":"Rac-driven dendritic spine morphogenesis","description":"The top GO terms converge on Rac protein signal transduction and actin cytoskeleton remodeling, especially processes like lamellipodium/ruffle assembly and dendritic spine morphogenesis, with hippocampus development as a neuronal context. This suggests the cluster comprises proteins involved in Rac-driven remodeling of the neuronal cytoskeleton to enable spine formation, a core aspect of synaptic development. Some terms point to broader roles in cell migration and complex assembly, but the strongest signal is neuronal spine morphogenesis.","confidence":"High","size":15,"edges":59,"triangles":75,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045792","count":11},{"id":"GO:0010592","count":11},{"id":"GO:0097178","count":11},{"id":"GO:0060999","count":11},{"id":"GO:0016601","count":11}]},{"hash":"1278217480446023517","title":"Neural development and organogenesis","description":"The top GO terms span neural development and function (long-term synaptic potentiation, telencephalon development, memory) and several organogenesis processes (odontogenesis, nail development, bone mineralization, renal system development). This mix suggests proteins involved in developmental programs across tissues with a strong neural component. The absence of edges further indicates a broad, non-specific cluster rather than a single pathway, so the label emphasizes neural development in the context of broader organogenesis.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":2},{"id":"GO:0042475","count":2},{"id":"GO:0021537","count":1},{"id":"GO:0051560","count":1},{"id":"GO:0035994","count":1}]},{"hash":"2068116733992511583","title":"Neural development and myelination","description":"The cluster is dominated by terms related to nervous system development, myelination, corpus callosum development, and synapse assembly, with supporting signaling and mechanotransduction roles. While some terms touch broader developmental processes (collagen organization, fat cell differentiation, kidney development) the strongest theme centers on neural development and maturation, including RTK signaling that guides neural differentiation and synaptic formation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0007169","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0071260","count":2}]},{"hash":"844665419646384773","title":"Mitochondrial Transport and Metabolism","description":"This cluster is dominated by GO terms for transport of metabolites into and out of mitochondria (ADP, NAD, citrate, pyrimidine nucleotides) and key metabolic shuttles (malate-aspartate), along with mitochondrial membrane fission. The recurring theme is mitochondrial metabolite exchange and energy metabolism, with a nod to insulin/IGF signaling effects on mitochondria. This suggests proteins in this cluster collectively support mitochondrial transport, metabolism, and dynamics rather than a single transporter protein family.","confidence":"High","size":15,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":14},{"id":"GO:0000066","count":14},{"id":"GO:0043490","count":14},{"id":"GO:0090149","count":14},{"id":"GO:0032869","count":14}]},{"hash":"1231935798126192566","title":"Coagulation and Tissue Remodeling","description":"This cluster centers on hemostasis and regulatory processes affecting wound healing and fibrosis, including platelet aggregation, blood coagulation, and negative regulation of fibroblast migration and hepatic stellate cell activation. While some terms (oxygen transport, receptor-mediated endocytosis, nitrogen fixation, slow-twitch muscle contraction) are less directly tied to coagulation, the dominant signals point toward vascular remodeling and tissue repair functions.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":3},{"id":"GO:0016049","count":2},{"id":"GO:0016311","count":2},{"id":"GO:2000490","count":2},{"id":"GO:0007596","count":2}]},{"hash":"594554013505358350","title":"Hair follicle morphogenesis and skin keratinization","description":"This cluster is dominated by GO terms related to skin and epithelial differentiation: hair follicle morphogenesis and keratinization, which points to a core theme of skin/follicle development. Additional terms about tissue remodeling (blood vessel remodeling, fibroblast migration) and protein ubiquitination suggest dynamic epidermal remodeling and regulation. Immune-related terms are present but seem secondary to the keratinized epidermal theme.","confidence":"Medium","size":15,"edges":49,"triangles":55,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":3},{"id":"GO:0031424","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0042832","count":3}]},{"hash":"717348726451926176","title":"Unknown","description":"The terms are a mix of barrier/junction-related processes and various developmental and immune/neural functions, with no single dominant theme tying the proteins together. This suggests no cohesive, interpretable function for the cluster as a whole.","confidence":"","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0001713","count":1},{"id":"GO:0034115","count":1},{"id":"GO:0070830","count":1},{"id":"GO:0001766","count":1}]},{"hash":"188984674399190475","title":"RNA processing and translational initiation regulation","description":"This cluster is enriched for RNA metabolism and control of protein synthesis: spliceosome- and ncRNA-mediated regulation, mRNA splicing and stability, mRNA export, polyadenylation, ribosome biogenesis via small-subunit processome assembly, and regulation of translational initiation including eIF4F assembly and IRES-dependent translation. The common theme is post-transcriptional control of gene expression at both RNA processing and translation levels.","confidence":"High","size":15,"edges":89,"triangles":311,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0010610","count":9},{"id":"GO:0034462","count":7},{"id":"GO:0006378","count":7}]},{"hash":"703080781502085282","title":"Translation initiation and ribosome assembly","description":"The main terms point to translation initiation, preinitiation complex formation, elongation, and small-subunit processome assembly, indicating a cluster tied to translational control and ribosome biogenesis. A few actin-related terms are present but secondary to the translation-focused signals.","confidence":"High","size":15,"edges":22,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032232","count":3},{"id":"GO:0006446","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0000147","count":2},{"id":"GO:0006414","count":2}]},{"hash":"2074199570496221727","title":"RNA Processing and Ribosome Biogenesis","description":"The top GO terms are dominated by RNA processing/splicing (GO:0000380, GO:0000381) and mRNA polyadenylation (GO:0006378), plus ribosome-related assembly and translation initiation (GO:0034462, GO:0097010, GO:0075522). This points to a cohesive cluster of proteins involved in RNA maturation (splicing/processing) and ribosome biogenesis/translation, with some regulatory terms as secondary associations.","confidence":"High","size":15,"edges":18,"triangles":8,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":3},{"id":"GO:0000380","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0051533","count":2}]},{"hash":"74280688821890322","title":"Cofactor biosynthesis and RNA modification","description":"The cluster is enriched for biosynthetic processes of cofactors (biotin and menaquinone) and post-translational/RNA modification activities (lipoylation, tRNA methylation, N-terminal peptidyl-glycine methylation, peptidylthioaspartate methylation), suggesting a cohesive theme around cofactor assembly and molecular modification; a few antibiotic-related terms may reflect broader secondary metabolism contexts.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":4},{"id":"GO:0009234","count":4},{"id":"GO:0030488","count":3},{"id":"GO:0018013","count":2},{"id":"GO:0017000","count":2}]},{"hash":"830411117829979812","title":"Ribosome Biogenesis and Translation Initiation","description":"The cluster is dominated by GO terms tied to ribosome assembly and initiation of translation, including ribosome biogenesis, formation of the translation preinitiation complex, translation itself, eIF4F complex assembly, and IRES-dependent translation, with supporting signals of stress-related mRNA stability regulation and small-subunit processome assembly, indicating a cohesive role in the production and initiation of protein synthesis.","confidence":"High","size":15,"edges":50,"triangles":31,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0071805","count":2}]},{"hash":"67186403224069423","title":"Organogenesis and developmental signaling (heart/retina)","description":"The top GO terms point to organ development and morphogenesis (retina layer formation, heart development, EMT) with signaling involvement (Wnt calcium pathway, regulation of DNA binding, and protein kinase activity). Additional terms related to neuronal excitability (potassium channel clustering, synaptic vesicle endocytosis) and metabolism (glycogen catabolism, insulin secretion) suggest a cluster of proteins coordinating developmental signaling with cellular energy states and excitability. Overall, it fits a developmental signaling/organogenesis theme rather than a single metabolic pathway.","confidence":"Medium","size":15,"edges":15,"triangles":2,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010842","count":10},{"id":"GO:1900242","count":10},{"id":"GO:0043388","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0045163","count":7}]},{"hash":"1873805941267641938","title":"Unknown","description":"The enriched terms span signaling (Notch), various amino acid and vitamin-related metabolic processes (kynurenine and alanine catabolism, pyridoxine biosynthesis), translation, and stress responses (glucocorticoid, vitamin B6). This mix lacks a single cohesive biological theme, suggesting the cluster may be functionally diverse or multifunctional rather than representing one clear pathway.","confidence":"","size":15,"edges":27,"triangles":30,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":4},{"id":"GO:0051591","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0006412","count":2}]},{"hash":"353220593558716325","title":"SNARE-driven synaptic vesicle trafficking and exocytosis","description":"These terms converge on SNARE-mediated vesicle trafficking related to exocytosis at the synapse, including SNARE complex assembly, docking/priming, and vesicle fusion in ER-Golgi and Golgi-to-plasma membrane pathways, plus receptor insertion and plasticity-related processes like LTP. ","confidence":"High","size":15,"edges":23,"triangles":10,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":4},{"id":"GO:0090161","count":4},{"id":"GO:0035493","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0006888","count":4}]},{"hash":"228385595518913988","title":"Chromatin Acetylation and Regulation","description":"The cluster is dominated by GO terms tied to acetylation (histone H4 acetylation; N-terminal and peptidyl acetylations on serine, glutamic acid, and lysine; peptidyl-lysine acetylation) and a term for subtelomeric heterochromatin formation, which together point to chromatin modification and regulation via acetylation. Some metabolic terms appear incidental (annotation noise or broad associations), but the acetylation/chromatin theme is strong.","confidence":"High","size":15,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":11},{"id":"GO:0010125","count":10},{"id":"GO:0001525","count":10},{"id":"GO:0060358","count":10},{"id":"GO:0017198","count":10}]},{"hash":"872520767916194066","title":"Calcium\u2013MAPK signaling in heart and retina","description":"The GO terms point to regulation of MAPK pathways (ERK1/2, p38) together with calcium handling via RyR and SR calcium release, in contexts of heart development and visual perception, plus vascular signaling via VEGF\u2014all suggesting a cluster coordinating calcium signaling and MAPK regulation in cardiac and retinal development.","confidence":"High","size":15,"edges":24,"triangles":17,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070373","count":4},{"id":"GO:0030948","count":4},{"id":"GO:0042994","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1846053487984212916","title":"Ribosome Biogenesis and Cell Cycle","description":"The cluster is enriched for GO terms related to ribosome biogenesis and ribosomal small subunit biogenesis, as well as tRNA modification, cell cycle, and cell division, pointing to a coordinated role in ribosome production and cell proliferation. Some less central terms about oxidative stress responses appear but do not override the core theme. ","confidence":"High","size":15,"edges":96,"triangles":352,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":7},{"id":"GO:0007049","count":7},{"id":"GO:0006400","count":7},{"id":"GO:0051301","count":7},{"id":"GO:1902083","count":6}]},{"hash":"884390700904374389","title":"Tissue development and inflammatory response","description":"The top GO terms include multiple organ development processes (nipple morphogenesis, lung connective tissue development, metanephric glomerulus development, endocardial cushion development) together with inflammatory-related terms (inflammatory response, macrophage activation), suggesting a cluster of proteins involved in broad tissue morphogenesis alongside immune activity rather than a single, tight pathway. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0072224","count":2},{"id":"GO:0003197","count":2}]},{"hash":"68433315540217234","title":"Synaptic organization and receptor trafficking","description":"This cluster is dominated by neuronal synapse-related terms: postsynaptic membrane assembly, synaptic vesicle clustering, regulation of receptor recycling, and terminal button organization, all core to synapse structure and neurotransmission. Additional retina development and circadian wakefulness terms point to broader neuronal signaling roles, and APP metabolism aligns with neuronal processing at synapses. Together these suggest a cohesive theme of synaptic organization and receptor trafficking in neurons.","confidence":"High","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":9},{"id":"GO:0050783","count":6},{"id":"GO:0097104","count":6},{"id":"GO:0001919","count":6},{"id":"GO:0097091","count":6}]},{"hash":"2127479920745814474","title":"Redox Homeostasis and Detoxification","description":"The cluster is dominated by GO terms for cellular oxidant detoxification, cell redox homeostasis, and glutathione metabolism, pointing to a shared role in managing oxidative stress. Prostaglandin biosynthesis and starvation response suggest linked metabolic and inflammatory signaling, while nucleotide-excision repair indicates DNA damage response under stress. A few calcium signaling/muscle contraction terms are present but represent a smaller portion, so the core theme remains redox/detoxification and stress adaptation.","confidence":"High","size":15,"edges":49,"triangles":121,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0001516","count":5},{"id":"GO:0045454","count":5},{"id":"GO:0006749","count":5},{"id":"GO:0009072","count":4}]},{"hash":"545011575995068527","title":"RNA Processing and Translation Initiation","description":"This cluster is dominated by splicing-related terms (spliceosome, processome), mRNA export, and regulation of mRNA stability, with additional signals for translation initiation complex assembly and IRES-dependent initiation. Together these terms point to a post-transcriptional RNA metabolism module that controls mRNA maturation, export, and early translation, including ncRNA-mediated gene silencing.","confidence":"High","size":15,"edges":103,"triangles":430,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0010610","count":8},{"id":"GO:0000398","count":7},{"id":"GO:0006378","count":6}]},{"hash":"1881812608207965771","title":"Amino acid biosynthesis and metabolism","description":"The top GO terms are dominated by amino acid biosynthetic processes (lysine and arginine) with related metabolic activities (fatty acid catabolism, peptide catabolism) and some translation/protein-synthesis\u2013related terms (mitochondrial translation, ER organization). While the terms are somewhat diverse, the common thread is amino acid metabolism linked to broader cellular metabolism and protein handling, so the label reflects this overarching theme. ","confidence":"Medium","size":15,"edges":36,"triangles":63,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0009089","count":4},{"id":"GO:0019877","count":4},{"id":"GO:0019878","count":3},{"id":"GO:0006526","count":3},{"id":"GO:0019876","count":2}]},{"hash":"1387620851293780641","title":"Embryonic Organ Development","description":"This set centers on developmental processes across multiple tissues and organs (lens, digestive tract, neural crest, pancreas, limb buds, ureteric bud), highlighting morphogenesis and organ formation rather than a single pathway. The presence of a few unrelated terms (e.g., transcription regulation) does not override the overall developmental theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001111","count":3},{"id":"GO:0048557","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0031018","count":3},{"id":"GO:0035767","count":3}]},{"hash":"222668942435220529","title":"Central Carbon Metabolism (Glycolysis & TCA)","description":"The cluster is dominated by terms for core energy metabolism, notably glycolysis and the TCA cycle, with supporting pathways like alanine and amino acid catabolism and pyruvate-to-acetyl-CoA regulation. While there are a few signaling terms (Notch, insulin response), the strongest signals point to metabolic flux and energy production rather than a single signaling cascade, making a central metabolism label appropriate.","confidence":"Medium","size":15,"edges":101,"triangles":405,"max_degree":14,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006099","count":6},{"id":"GO:0042853","count":4},{"id":"GO:0006096","count":4},{"id":"GO:0032869","count":3},{"id":"GO:0097053","count":3}]},{"hash":"2009153809518031886","title":"GPCR-Driven cGMP Signaling Pathway","description":"The cluster centers on GPCR-mediated signaling (adenosine and adrenergic pathways) and receptor guanylyl cyclase signaling, with strong representation of cGMP biosynthesis and downstream signaling, plus related blue-light/phytotransduction contexts. This suggests a cohesive theme of intracellular signaling initiated by GPCRs that converges on cGMP production and related regulatory cascades, with some cross-talk to cAMP pathways (forskolin response) but a clear emphasis on cGMP signaling.","confidence":"High","size":15,"edges":13,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035556","count":9},{"id":"GO:0001973","count":8},{"id":"GO:1904322","count":8},{"id":"GO:0030828","count":8},{"id":"GO:0007168","count":8}]},{"hash":"869814932857992620","title":"Xenobiotic Metabolism and P450 Epoxygenase Pathway","description":"The cluster is driven by GO terms tied to detoxification and processing of xenobiotic/organic compounds, notably carbazole catabolic process, xenobiotic catabolic process, and the epoxygenase P450 pathway, suggesting a shared function in xenobiotic metabolism. Other terms like vancomycin biosynthesis also point to metabolic processing, while some terms (e.g., sex differentiation, maternal processes) may reflect pleiotropy or broader expression. Overall, the dominant theme is detoxification/metabolism of external compounds via P450-related pathways.","confidence":"Medium","size":15,"edges":9,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":14},{"id":"GO:0035865","count":13},{"id":"GO:1900087","count":13},{"id":"GO:0033072","count":13},{"id":"GO:0010760","count":13}]},{"hash":"1290663998559526224","title":"Neuronal Synapse Organization and Signaling","description":"The top GO terms point to synaptic structure and function\u2014postsynaptic membrane assembly, synaptic vesicle clustering, receptor recycling, and terminal button organization\u2014plus APP metabolism and retinal development, all indicating a cluster of proteins involved in synapse assembly, maintenance, and signaling, with brain/retina-specific roles and circadian regulation cues. This cohesive theme supports a neuronal synaptic function label.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0050783","count":11},{"id":"GO:0097104","count":11},{"id":"GO:0001919","count":11},{"id":"GO:0060041","count":11},{"id":"GO:0097091","count":11}]},{"hash":"1077350200110391233","title":"ER stress response and secretory pathway","description":"This cluster is dominated by GO terms related to handling unfolded proteins, ER-associated stress responses, and cotranslational targeting to membranes, which together point to the secretory pathway and protein quality control. Peripheral terms about fungal cell wall biosynthesis and immune signaling may reflect contextual cues (host\u2013fungal interactions) but do not define the core function of the cluster. ","confidence":"Medium","size":15,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":3},{"id":"GO:0090084","count":2},{"id":"GO:1903382","count":2},{"id":"GO:0006880","count":2},{"id":"GO:0016226","count":2}]},{"hash":"1294629434171332954","title":"Negative regulation of MAPK and immune receptor signaling","description":"The cluster is enriched for GO terms describing negative regulation of signaling, particularly MAPK/ERK cascades and immune receptor signaling (TCR, IL-2), as well as growth factor receptor pathways (VEGF, PDGFR). This suggests a common function in dampening receptor-mediated signaling and downstream MAPK activity; a few terms (e.g., vestibular morphogenesis) may be less connected and represent noise or broader roles. ","confidence":"High","size":15,"edges":103,"triangles":430,"max_degree":14,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0030948","count":12},{"id":"GO:0050860","count":11},{"id":"GO:0070373","count":11},{"id":"GO:0000200","count":11},{"id":"GO:1902206","count":9}]},{"hash":"1781567269182661056","title":"Phytochrome-based red/far-red light signaling and transcription","description":"This cluster centers on plant light sensing, especially red/far-red phototransduction and detection of visible light, with signaling pathways leading to transcriptional regulation. Chromophore/tetrapyrrole linkage terms reinforce the idea of phytochrome-like photoreceptors carrying a tetrapyrrole chromophore, linking light perception to gene expression and downstream cellular responses.","confidence":"High","size":15,"edges":71,"triangles":155,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":6},{"id":"GO:0009585","count":5},{"id":"GO:0000160","count":5},{"id":"GO:0009584","count":5},{"id":"GO:0018298","count":5}]},{"hash":"797696948315250712","title":"Fungal mating and DNA replication with stress response","description":"The top terms emphasize karyogamy (mating-related cellular fusion) and DNA replication, pointing to fungal reproductive/cell-cycle processes. Additional terms cover fungal cell wall biosynthesis, protein folding and ER stress responses, and oxidative stress signaling, suggesting a cluster tied to fungal growth/reproduction with concurrent stress management. While diverse, the dominant fungal mating/replication signals make this label representative.","confidence":"Medium","size":15,"edges":80,"triangles":227,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":10},{"id":"GO:0006260","count":10},{"id":"GO:0090084","count":9},{"id":"GO:1903382","count":9},{"id":"GO:0006880","count":9}]},{"hash":"1209199880018074795","title":"Vertebrate Embryonic Development and Gene Regulation","description":"The top GO terms cluster around broad vertebrate development (brain/forebrain, hindlimb, placenta, embryonic structures) and a central role in transcriptional regulation (negative regulation of transcription by RNA polymerase II), suggesting proteins that coordinate developmental processes through gene expression control rather than a single tissue-specific function. Minor terms like triglyceride homeostasis may reflect metabolic coordination during development, but the dominant theme is developmental regulation. ","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0008584","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0030900","count":4}]},{"hash":"2005525709111344372","title":"Coagulation and Complement Activation","description":"The cluster\u2019s top GO terms concentrate on blood coagulation, fibrinolysis, plasminogen activation, and complement pathways (classical and lectin), with negative regulation of platelet aggregation and adaptive immune response also represented. This points to a cohesive theme around hemostasis intertwined with innate/adaptive immunity, with some peripheral stress responses (hypoxia, UV protection) that may be incidental. ","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0009650","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1731519590069308102","title":"EMT-Associated Stress Signaling and Transcription Regulation","description":"These proteins show GO terms tied to epithelial to mesenchymal transition, transcriptional regulation by RNA polymerase II, hypoxia response, calcium and oxidative signaling, and cytoskeletal transport, suggesting a shared role in signaling networks that drive cell-state changes and stress responses, with EMT as a core anchor and transcriptional control as a common thread. Some terms also touch on development, supporting a broader role in tissue remodeling contexts. Confidence in a single cohesive theme is moderate due to the diverse functions present.","confidence":"Medium","size":15,"edges":16,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001837","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0035774","count":2},{"id":"GO:1901841","count":2},{"id":"GO:0035191","count":2}]},{"hash":"1846532113756967606","title":"Steroid Hormone Biosynthesis and Lipid Metabolism","description":"This cluster is strongly enriched for steroid hormone biosynthesis terms (estrogen, testosterone, androgen catabolic process, and glucocorticoid biosynthesis) and related lipid/n.long-chain fatty acid biosynthesis, indicating a unit focused on steroid production and lipid metabolism. Less central terms like antibiotic biosynthesis and poly-hydroxybutyrate biosynthesis appear as noise relative to the dominant steroid/lipid theme.","confidence":"High","size":15,"edges":56,"triangles":92,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":10},{"id":"GO:0006355","count":10},{"id":"GO:0055114","count":9},{"id":"GO:0042619","count":9},{"id":"GO:0008207","count":8}]},{"hash":"1027308810536140573","title":"Autophagy and Epigenetic Regulation","description":"The top GO terms prominently feature autophagy, epigenetic programming of gene expression, and related regulation of proteostasis, suggesting a cluster centered on cellular quality control and gene-expression regulation. Some outlier terms (placenta morphogenesis, NF-kappaB, MHC I biosynthesis) may reflect broader regulatory contexts or annotation noise, but the shared theme points to autophagy and epigenetic regulation of cellular function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006914","count":2},{"id":"GO:1900458","count":2},{"id":"GO:2000059","count":2},{"id":"GO:0060669","count":2},{"id":"GO:1901536","count":2}]},{"hash":"1992978087760333457","title":"Regulation of signaling and gene expression","description":"The top GO terms point to broad regulatory processes: NF-kappaB signaling, IL-17 signaling, autophagy, ubiquitin-dependent protein degradation, miRNA metabolism, and epigenetic regulation (DNA demethylation). While there are outlier terms related to development and plant signaling, the common thread is modulation of signaling pathways and gene expression as a central theme in this cluster.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":8},{"id":"GO:0006914","count":7},{"id":"GO:1900458","count":7},{"id":"GO:0072089","count":7},{"id":"GO:2000059","count":7}]},{"hash":"1660909176747282992","title":"Endocytosis and Receptor Signaling","description":"The top GO terms cluster around membrane trafficking and receptor-mediated signaling, including clathrin-dependent endocytosis, GPCR internalization, and insulin receptor signaling. Several terms reflect cellular responses to external stimuli (interleukin-4, xenobiotic stimulus), suggesting a shared role in receptor cycling and signal propagation. Although there are developmental terms (heart and retina development), these can reflect tissue-specific roles of endocytic signaling pathways, making this a concise umbrella name.","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0071353","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0072583","count":2}]},{"hash":"1156869761004494337","title":"DNA Damage Response and Transcription Regulation","description":"This cluster centers on proteins implicated in sensing and signaling DNA damage and in regulating transcription in response to that damage (gamma radiation response, p53-related pathways, transcription termination and elongation regulation, and potential apoptosis downstream). A few terms like ribosome biogenesis and DNA transposition are less directly tied but may reflect broader stress responses or annotation overlap. Overall, the dominant theme is DNA damage signaling coupled with transcriptional control.","confidence":"Medium","size":15,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0042273","count":1},{"id":"GO:0031564","count":1},{"id":"GO:0042256","count":1}]},{"hash":"742568663157390676","title":"Neural development and synaptic function","description":"The terms cluster around brain development, behaviors mediated by neural circuits (adult locomotory and grooming behavior), and synaptic vesicle endocytosis, with supporting neuronal cellular processes such as depalmitoylation and lysosomal acidification. While a few metabolism-related terms appear, the dominant pattern is neural development and synaptic regulation, justifying this label.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0008344","count":4},{"id":"GO:0043473","count":4},{"id":"GO:0007042","count":3},{"id":"GO:0016042","count":3}]},{"hash":"1134976250361310299","title":"Developmental signaling and epithelial polarity","description":"Top GO terms reflect signaling pathways and cellular processes involved in development and tissue organization, notably Wnt signaling (GO:0016055), Rho-mediated signal transduction, and establishment of epithelial cell polarity with tight junction assembly. The presence of brain development and synapse plasticity terms suggests broader roles in nervous system development, while angiogenesis points to vascular aspects of growth. Taken together, these terms indicate a theme around developmental signaling that organizes cell polarity and tissue architecture rather than a single, narrow function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0016055","count":3}]},{"hash":"1827285474054101060","title":"Unknown","description":"The GO terms span viral integration and proviral latency, host-symbiont entry, apoptotic processes, and several Drosophila developmental terms (oskar mRNA regulation, posterior head segmentation, muscle development) with no obvious shared pathway. Because there is no uniting biological theme across the cluster, a single interpretable label cannot be assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0046718","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0046011","count":2},{"id":"GO:1902108","count":2}]},{"hash":"1531703387243883873","title":"Regulated cell motility and adhesion signaling","description":"This cluster centers on GO terms related to controlling cell movement and adhesion, including regulation of cell motility, integrin-mediated signaling, and Notch signaling, with supporting terms in development (retina vasculature) and junction assembly. While a viral attachment term is an outlier, the dominant pattern is signaling pathways that modulate how cells move and interact with their environment.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000145","count":5},{"id":"GO:1901223","count":5},{"id":"GO:2001046","count":5},{"id":"GO:0046813","count":5},{"id":"GO:0043128","count":5}]},{"hash":"314282736501270826","title":"Glutathione-dependent detoxification and oxidative stress response","description":"The cluster shows strong enrichment for oxidative detoxification and glutathione metabolism (GO:0098869, GO:0006749), along with toxin catabolic processes and starvation response, pointing to a core function in redox balance and detox pathways. While some terms relate to DNA repair and calcium signaling, these are secondary and do not define the main theme. Overall, detoxification and oxidative stress response best represent the cluster.","confidence":"Medium","size":15,"edges":101,"triangles":406,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":14},{"id":"GO:0009072","count":13},{"id":"GO:0006749","count":13},{"id":"GO:0060316","count":13},{"id":"GO:0014810","count":13}]},{"hash":"1768844850313155060","title":"Neuronal signaling and sensory processing","description":"This cluster is enriched for ion transport across membranes and membrane depolarization, core aspects of neuronal excitability, together with synaptic signaling pathways (GABA, serotonin, dopamine), sensory perception (sound detection), and related behaviors (locomotion, conditioned taste aversion). The common thread is neuronal communication driving sensory processing and behavior.","confidence":"High","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":12},{"id":"GO:0035725","count":12},{"id":"GO:0060079","count":12},{"id":"GO:0051899","count":11},{"id":"GO:0007626","count":11}]},{"hash":"606283333772844234","title":"Neural Development and Innate Immune Signaling","description":"These top GO terms show strong neural development signals (synapse assembly, myelination, axonal fasciculation, otolith morphogenesis) alongside innate immune and inflammatory responses (innate immune response, cytokine production, LPS response). The mix suggests proteins involved in nervous system development that also participate in immune/inflammatory signaling, indicating possible neuroimmune crosstalk or broad annotation rather than a single narrow function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":10},{"id":"GO:0042552","count":8},{"id":"GO:0007413","count":8},{"id":"GO:0014068","count":8},{"id":"GO:0032474","count":8}]},{"hash":"930177060335196822","title":"Neural development and ion channel clustering","description":"This cluster shows strong signals for nervous system development terms such as nerve development and axon paranode localization, along with ion channel-related processes like clustering of voltage-gated potassium channels and sodium ion transport. While other terms touch on immune and vascular signaling, the most prominent and recurring themes are neural development and ion channel organization, justifying a neural-center label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0045163","count":3},{"id":"GO:0038095","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0035725","count":3}]},{"hash":"2210549493910761589","title":"DNA Integration and Transposition","description":"This cluster is dominated by GO terms related to movement and integration of DNA, including DNA integration, DNA transposition, and integrated proviral latency, suggesting a theme around transposable elements and proviral genomes. Additional terms about cell cycle and chromosome segregation may reflect host genome dynamics during element activity, with some signaling and stress-response terms appearing as ancillary responses. Overall, the core theme aligns with mobility of genetic elements and proviral integration.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0010880","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007059","count":2},{"id":"GO:0006313","count":2}]},{"hash":"494507222529238954","title":"ERAD-Glycoprotein Quality Control","description":"The cluster is dominated by GO terms for ubiquitin-dependent glycoprotein ERAD, mannose trimming of N-glycans, and retrograde transport from the ER to the cytosol, pointing to a shared role in glycoprotein quality control and degradation; a few terms, like histone mRNA catabolic process, appear peripheral.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071044","count":2},{"id":"GO:0016925","count":2},{"id":"GO:1904381","count":1},{"id":"GO:0036509","count":1},{"id":"GO:0036512","count":1}]},{"hash":"1103714509398795880","title":"Retina development and phototransduction","description":"Two of the top terms are specifically about retina: retina development in camera-type eye and phototransduction. Although there are additional terms related to signaling and ubiquitination, the retina-related terms strongly define the cluster\u2019s functional theme, supporting a vision/eye development interpretation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032691","count":4},{"id":"GO:0032717","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0035774","count":3}]},{"hash":"805588489905470594","title":"Neurotransmitter Uptake and Synaptic Regulation","description":"This cluster is dominated by terms for neurotransmitter transport and synaptic signaling, especially glycine uptake/transport and glycinergic regulation, with additional entries for dopamine and serotonin uptake and general regulation of synaptic transmission. The presence of proline transport and glycine-related processes aligns with neuronal transporter activity and synaptic maintenance, supporting a single theme of neuronal neurotransmitter handling and synaptic regulation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903346","count":1},{"id":"GO:0061537","count":1},{"id":"GO:0036233","count":1},{"id":"GO:0051610","count":1},{"id":"GO:0042066","count":1}]},{"hash":"1975840362822213582","title":"Developmental Growth and RNA-Based Regulation","description":"This cluster centers on developmental processes such as multicellular growth, skin development, stem cell proliferation, and placental morphogenesis, indicating a theme of developmental growth. It is complemented by RNA- processing and regulatory activities (mRNA splicing, miRNA metabolism) and proteostasis-related processes (autophagy, ubiquitin-mediated protein turnover), suggesting coordination between gene expression control and protein homeostasis during development. The plant-specific brassinosteroid signaling term points to a broader, cross-kingdom growth-regulation context. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0006914","count":2},{"id":"GO:1900458","count":2}]},{"hash":"353431924057520221","title":"Immune signaling and lymphocyte differentiation","description":"The top GO terms center on adaptive immunity: B cell receptor signaling, dendritic cell differentiation, memory T cell differentiation, and regulation of mast cell cytokine production, indicating a cluster dominated by immune signaling and lymphocyte development. Some non-immune terms in the list may reflect noise or broader annotations, but the core theme is immune signaling. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:2000312","count":3},{"id":"GO:0048008","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0043380","count":2}]},{"hash":"2106979419978527584","title":"Ubiquitination and Transcriptional Signaling","description":"The top GO terms point to post-translational regulation via ubiquitination and PARylation, plus DNA-templated transcription, with accompanying signaling-related processes (calcium release, muscle stretch response, and differentiation). This suggests a cluster of proteins involved in regulating gene expression through PTMs and signaling pathways, rather than a single cohesive pathway, hence a broad label focused on ubiquitination and transcriptional signaling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0051209","count":2},{"id":"GO:0046475","count":2}]},{"hash":"309303956299336257","title":"Regulation of development and immune responses","description":"This set of GO terms points to proteins involved in broad regulatory roles that affect both development (eye/multicellular development, regulation of protein interactions) and immune signaling (protein ubiquitination, dsRNA response, defense against virus, T cell chemotaxis, vitamin D response, mitochondrial fission). The mix suggests a general regulatory cluster rather than a single pathway, so a medium confidence label reflecting this cross-domain regulation is appropriate.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0033280","count":5},{"id":"GO:0043010","count":4},{"id":"GO:0032464","count":4},{"id":"GO:0002230","count":4}]},{"hash":"1345993204147854252","title":"Embryonic Tissue Development","description":"Most terms cluster around developmental and tissue formation processes across multiple organs (bone mineralization, chondrocyte differentiation, alveolus and digestive tract development, cardiac muscle proliferation), indicating a general developmental/differentiation theme for the proteins. Some terms (DNA integration, gravitropism, Golgi transport regulation) are outliers, but do not negate the overall developmental signal.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009958","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0048286","count":1},{"id":"GO:0030282","count":1},{"id":"GO:0030501","count":1}]},{"hash":"2129052728397224012","title":"Neuronal Ion Transport and Behavioral Regulation","description":"The cluster prominently features GO terms for potassium and sodium ion transmembrane transport, salt-stress response, and neural/behavioral processes (locomotory/adult walking behavior, response to cocaine, regulation of neuron apoptosis). Together, these imply a theme of neural ion homeostasis influencing signaling and behavior, with neuroprotection aspects. Some outliers (blood coagulation, obsolete protein-chromophore linkage) are unrelated but do not negate the core neural/ion-transport signal.","confidence":"Medium","size":14,"edges":71,"triangles":194,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0018298","count":2},{"id":"GO:0007626","count":2}]},{"hash":"1743951270692697231","title":"Ion transport and cyclic nucleotide signaling","description":"The top GO terms point to membrane ion transport (potassium and sodium), membrane hyperpolarization, and cellular responses to cAMP and cGMP, suggesting a core theme around ion transport and cyclic nucleotide signaling. Other terms like aerotaxis, sensory pain perception, and gastric acid secretion are less directly tied and may reflect broader or species-specific annotations, but the dominant pattern supports ion transport coupled with cyclic nucleotide signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0010754","count":4},{"id":"GO:0098719","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0009454","count":4}]},{"hash":"809899817009066721","title":"Rho-regulated actin dynamics and cell motility","description":"The terms converge on actin cytoskeleton remodeling (lamellipodium/microspike assembly, crosslinking), Rho signaling regulation, and adhesion/polarity, pointing to coordinated cytoskeletal changes driving cell movement and shape. A heart development term may reflect morphogenesis-related actin dynamics but does not override the core theme.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007155","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0031532","count":3},{"id":"GO:0030035","count":3}]},{"hash":"1849828855112806210","title":"Telomere protection and NHEJ DNA repair","description":"The top GO terms are dominated by telomere-related and NHEJ repair activities (double-strand break repair via nonhomologous end joining, protection from NHEJ at telomeres, telomeric loop formation), suggesting a core function in telomere maintenance and DNA repair. Other signaling and developmental terms appear less central, so the label centers on telomere upkeep and DSB repair.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006303","count":2},{"id":"GO:0031848","count":2},{"id":"GO:0031627","count":2},{"id":"GO:0050852","count":1},{"id":"GO:0071364","count":1}]},{"hash":"2232159638567364181","title":"Ubiquitin-Dependent Proteolysis","description":"The top GO terms cluster around ubiquitin tagging and proteasomal degradation (ubiquitin-dependent protein catabolic process, polyubiquitination, K48/K6-linked ubiquitination, autoubiquitination, SCF-dependent degradation, ERAD), with related processes like histone catabolic activity and downstream signaling/apoptotic responses. This pattern indicates a core function in marking proteins for destruction via the ubiquitin-proteasome system, hence the label.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0000209","count":6},{"id":"GO:0085020","count":5},{"id":"GO:1903265","count":5},{"id":"GO:0036205","count":5}]},{"hash":"2247774792122311016","title":"Liver Fatty Acid Oxidation and BCAA Catabolism","description":"These proteins are enriched for fatty acid oxidation pathways (long-/medium-chain beta-oxidation, acyl-CoA oxidation) and carnitine-mediated transport, along with catabolism of branched-chain amino acids like leucine and valine. The inclusion of liver development and post-embryonic development terms suggests a hepatic, developmentally regulated metabolic context, making the label a coherent, specific summary of the cluster\u2019s predominant functions. ","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046939","count":2},{"id":"GO:0019254","count":2},{"id":"GO:0033540","count":2},{"id":"GO:0051793","count":2},{"id":"GO:0001889","count":2}]},{"hash":"416079080196051280","title":"TNF and NF-kB inflammatory signaling and apoptosis","description":"The top GO terms are dominated by TNF-mediated signaling, non-canonical NF-kappaB regulation, and intrinsic apoptotic signaling pathways, which together point to inflammatory/stress signaling and programmed cell death as the core theme of this cluster. There are a few outlier terms (e.g., keratinization, Golgi localization) that likely reflect broader cellular annotations or noise, but the dominant signal supports an inflammatory/apoptotic module. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0051683","count":2},{"id":"GO:0043154","count":2},{"id":"GO:0071901","count":2},{"id":"GO:0031424","count":2}]},{"hash":"293788048356557235","title":"Antiviral Interferon Response","description":"The top GO terms are dominated by responses to type I/II/III interferons and defense against virus, including negative regulation of viral genome replication. This points to a cluster of proteins involved in antiviral signaling and interferon-mediated immune responses. A few terms (GPI-anchor attachment, rhabdomere membrane biogenesis, autophagy targeting, dendrite extension, protein catabolic regulation) are more general or cell-type specific; they may reflect pleiotropic roles of these proteins or dataset noise, but they do not negate the central antiviral theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034341","count":1},{"id":"GO:0034340","count":1},{"id":"GO:0045071","count":1},{"id":"GO:0034342","count":1},{"id":"GO:0051607","count":1}]},{"hash":"1167428136859923246","title":"ERAD-Proteasome Regulation and Vesicle Trafficking","description":"The top GO terms emphasize ubiquitin-dependent ER-associated degradation and proteasome-mediated protein catabolic processes, along with protein deglycosylation and regulatory aspects of vesicle formation and receptor internalization. While there are also terms related to mitochondrial dynamics and cell cycle structures, the strongest signal is proteostasis via ERAD and proteasomal degradation, coupled with trafficking and endosomal processes. This suggests a cluster centered on protein quality control and membrane trafficking pathways.","confidence":"Medium","size":14,"edges":31,"triangles":43,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0032436","count":6},{"id":"GO:0045648","count":6},{"id":"GO:0071226","count":6},{"id":"GO:0006517","count":5}]},{"hash":"490848961120577138","title":"Unknown","description":"The top GO terms are diverse, including transcription, several developmental processes, and cell division, but also stress responses and transport terms. There isn\u2019t a single coherent function or pathway that ties these terms together, so a clear, specific label isn\u2019t supported.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0030707","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0043588","count":2}]},{"hash":"725469270437560219","title":"Unknown","description":"The top GO terms include Wnt signaling, cell cycle, tRNA modification, rRNA processing, nucleotide catabolic processes, and isoprenoid biosynthesis, spanning signaling, RNA biology, and metabolism with no clear single theme. There isn\u2019t a cohesive function that ties the cluster together, so a specific label isn\u2019t justifiable.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0006400","count":2},{"id":"GO:2000233","count":2},{"id":"GO:0006203","count":2}]},{"hash":"1115105963454504404","title":"Viral integration and host DNA metabolism","description":"The top GO terms emphasize DNA-centric processes (recombination, replication, repair, RNA-templated DNA biosynthesis) and viral/symbiont interactions (viral entry into the nucleus, proviral latency, host apoptosis activation, RNAi modulation). This points to a cluster of proteins involved in exploiting host DNA machinery during infection and maintaining proviral genomes, rather than a single metabolic pathway.","confidence":"Medium","size":14,"edges":66,"triangles":210,"max_degree":11,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0044209","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0006281","count":3},{"id":"GO:0039651","count":3}]},{"hash":"2290110076767367017","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":81,"triangles":260,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0007035","count":2},{"id":"GO:0045454","count":2},{"id":"GO:1905639","count":1},{"id":"GO:0016554","count":1}]},{"hash":"1843745284615789923","title":"Rho/Rac GTPase\u2013Mediated Cytoskeletal Remodeling in Immune Cells","description":"Enriched terms converge on Rho/Rac GTPase signaling and actin-based structures (lamellipodium/filopodium) with adhesion-dependent spreading, pointing to cytoskeletal remodeling. Immune-related terms (B cell maturation, IL-4 production, NK T cell differentiation) suggest this remodeling supports immune cell migration and signaling; heart development terms may reflect broader developmental roles of these pathways.","confidence":"High","size":14,"edges":19,"triangles":3,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":11},{"id":"GO:0030032","count":10},{"id":"GO:1900026","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0032633","count":10}]},{"hash":"1041383382167617270","title":"Neural development and sensory function","description":"The top GO terms cluster around neural and sensory biology: retina layer formation, visual perception, Schwann cell development, clustering of voltage-gated potassium channels, and regulation of synaptic vesicle endocytosis, all pointing to neural development and neuronal signaling. Some terms like heart development or epithelial-to-mesenchymal transition reflect broader developmental contexts but don\u2019t override the dominant neural/sensory theme. Overall, the cluster seems best described by neural development and sensory function.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0045163","count":7},{"id":"GO:0010842","count":7},{"id":"GO:0009738","count":7},{"id":"GO:0007601","count":7}]},{"hash":"871799839590870238","title":"Symbiont dormancy entry in host and stress response","description":"Dominant GO terms point to dormancy entry of symbiont in host and general stress response, suggesting a shared theme around dormant/survival states and host stress signaling. The other terms are sparse and cover diverse processes, and there are no edges, indicating a loose grouping rather than a tight functional module.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":9},{"id":"GO:0006950","count":9},{"id":"GO:0035329","count":1},{"id":"GO:0007611","count":1},{"id":"GO:0045165","count":1}]},{"hash":"2229337571376674863","title":"Developmental morphogenesis regulators","description":"These GO terms cluster around development and tissue morphogenesis, including heart development, eye morphogenesis, axis specification, and regulation of growth/signaling pathways (GTPase activity, cAMP signaling). The mix also touches on vascular and adipose remodeling and immune-related processes like phagocytosis, suggesting a broader role in developmental regulation of organogenesis and tissue morphogenesis rather than a single specific pathway.","confidence":"Medium","size":14,"edges":51,"triangles":97,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0043950","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0048632","count":2},{"id":"GO:0007313","count":2}]},{"hash":"1443380262554796017","title":"Embryonic eye and neural development","description":"The top GO terms point to embryonic morphogenesis with a focus on eye-related structures (embryonic camera-type eye morphogenesis, lens fiber cell differentiation) and neural development (axonogenesis, brain region development, somitogenesis). While a few terms are peripheral (erythrocyte differentiation, vitamin D regulation), the central theme is early vertebrate development, particularly eye and neural formation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006309","count":1},{"id":"GO:0030218","count":1},{"id":"GO:0001756","count":1},{"id":"GO:0060021","count":1},{"id":"GO:0045602","count":1}]},{"hash":"1827920026208675691","title":"Calcium-dependent signaling and cytoskeletal remodeling","description":"These proteins cluster around calcium signaling and cytoskeletal dynamics, with terms on regulation of calcium channels and import, calcium-modulated signaling in neurons and insulin secretion, muscle contraction, EMT-related motility, and actomyosin/cytoskeletal organization. The common thread is calcium acting as a central regulator that links signaling to structural remodeling across development, muscle function, and neuronal processes.","confidence":"High","size":14,"edges":11,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048168","count":6},{"id":"GO:0001837","count":5},{"id":"GO:0007223","count":5},{"id":"GO:0035774","count":5},{"id":"GO:1901841","count":5}]},{"hash":"1889175301866710895","title":"Developmental Signaling and Morphogenesis","description":"The cluster includes organ development terms (kidney, nervous system, heart), major signaling pathways (Smoothened/Hedgehog, Roundabout/Robo), and broader signaling (T cell receptor, small GTPase) along with cytoskeletal and organelle dynamics (filopodium regulation, mitochondrial fission). This suggests a cohesive theme of signaling-driven development and morphogenesis across tissues.","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0007399","count":5}]},{"hash":"534365110129523156","title":"Inflammatory signaling and cytokine regulation","description":"This cluster centers on immune-related GO terms: response to lipopolysaccharide, inflammatory response, IL-6 production regulation, and ERK signaling, plus GPCR and Rho pathway involvement. Together they suggest proteins involved in inflammation and cytokine signaling, with some outliers (heart development, cocaine response) that may reflect pleiotropy or annotation noise. Overall, a coherent theme around inflammatory signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0010579","count":2},{"id":"GO:0048148","count":2}]},{"hash":"1156120924281454419","title":"Neural development and axon guidance signaling","description":"The cluster\u2019s top GO terms cluster around nervous system development, axon guidance, ROBO signaling, and Hedgehog/Smoothened pathways, all central to neural pathfinding and maturation. Although a few terms touch immune signaling, the dominant theme is neural development and guidance, with ERK/MAPK signaling modulators often implicated in such processes.","confidence":"High","size":14,"edges":14,"triangles":5,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002551","count":9},{"id":"GO:0035385","count":9},{"id":"GO:0043931","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0043552","count":9}]},{"hash":"691470814017038387","title":"Calcium signaling in muscle and heart function","description":"GO terms show a strong emphasis on calcium ion regulation and calcium-activated signaling (regulation of SA node action potential, high-voltage calcium channel activity, calcium import, Wnt calcium pathway) and on muscle-related processes (diaphragm contraction). Other terms like EMT and cytoskeletal transport can be connected to broader calcium-dependent cellular regulation. Overall, the cluster reflects calcium-mediated signaling driving muscle and heart function.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098907","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0001837","count":3},{"id":"GO:0007223","count":3},{"id":"GO:0035774","count":3}]},{"hash":"2280413598200556482","title":"Embryonic Organ Morphogenesis","description":"The top GO terms center on embryonic and organ morphogenesis across heart, eye/retina, prostate, ovary, and bone, with a general transcription component, suggesting a cluster of development-related proteins involved in early organogenesis across multiple tissues.","confidence":"Medium","size":14,"edges":9,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055010","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0001701","count":4},{"id":"GO:0060528","count":4},{"id":"GO:0006366","count":4}]},{"hash":"346326868044638055","title":"Glycinergic and Monoaminergic Neurotransmission","description":"The terms cluster around glycine signaling and transport (import/secretion and glycinergic transmission regulation) and uptake of dopamine and serotonin, plus related neurotransmission processes. This points to a function centered on neurotransmitter handling at synapses, with possible glial involvement in CNS development. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":4},{"id":"GO:1903346","count":3},{"id":"GO:0061537","count":3},{"id":"GO:0036233","count":3},{"id":"GO:0051610","count":3}]},{"hash":"239062772322247974","title":"AGP and HRGP Glycosylation in Plants","description":"This cluster is dominated by terms related to arabinogalactan proteins (AGPs), hydroxyproline-rich glycoproteins (HRGPs), and their glycosylation and metabolism, as well as plant-specific processes like root hair development, seed coat mucilage, and cell-wall\u2013associated glycoprotein biosynthesis. Some outlier terms mention eye or neural development, likely annotation noise, but the core signal points to plant extracellular glycoproteins and their modifications.","confidence":"Medium","size":14,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0048593","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0030311","count":3}]},{"hash":"1808495390093759827","title":"Calcium signaling in neural and vascular development","description":"The terms point to calcium-centric signaling across neural and vascular contexts: a calcium-modulating Wnt pathway, calcium channel-related regulation, and calcium import control, alongside neural functions (astrocyte activation, visual perception) and vascular branching. This suggests a common thread of calcium-dependent signaling influencing neural and vascular development and function, with additional associations to insulin secretion and amyloid-related processes. Given the mix of calcium-focused terms and related neural/vascular processes, this label captures the core shared theme without over-committing to a single pathway.","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007223","count":2},{"id":"GO:0048143","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0001837","count":1}]},{"hash":"2259455340747183309","title":"Neural signaling and gene regulation","description":"The terms cluster around neural signaling (sensory perception of sound; GABAergic synaptic transmission) and gene regulation (ncRNA-mediated silencing; regulation of mRNA splicing; STAT phosphorylation), with supportive developmental/differentiation processes (cadherin-mediated adhesion, nephron tubule differentiation, endothelial barrier establishment) and even pigment biosynthesis. This blend suggests a theme centered on neural development and regulation of signaling and gene expression, though the connections are broad across contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0051932","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0048023","count":2}]},{"hash":"116669088574196208","title":"GTPase-driven signaling in neural development","description":"This cluster centers on small GTPase-mediated signal transduction and brain development, with associated terms like ERK1/ERK2 cascade regulation and neurotransmitter receptor transport, suggesting proteins involved in neural signaling and development. Some terms (e.g., mating projection growth, cell wall glucan biosynthesis) are peripheral or reflect broader signaling roles, but the dominant theme is GTPase-driven signaling in neural contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090051","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0007264","count":3},{"id":"GO:0090334","count":3},{"id":"GO:0050852","count":3}]},{"hash":"1155800539052203579","title":"Unknown","description":"The top GO terms span DNA repair, telomere maintenance, immune signaling (mast cell and monocyte regulation), and inner-ear development/vestibular functions, with no single dominant function tying the proteins together; plus there are no interactions shown (0 edges), so there isn\u2019t a cohesive theme to label.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":1},{"id":"GO:0000723","count":1},{"id":"GO:0032765","count":1},{"id":"GO:0048752","count":1},{"id":"GO:1900625","count":1}]},{"hash":"2292550277083807415","title":"Cell Cycle and RNA Processing Proteins","description":"This cluster is dominated by cell cycle and division terms (cell division, cell cycle) along with RNA processing and translation terms (tRNA modification, mRNA polyadenylation, cytoplasmic translation), suggesting a group of proteins involved in cell-cycle regulation and gene expression machinery. A few terms appear unrelated (sensory perception of sound) and may reflect annotation noise. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0001300","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0006378","count":2}]},{"hash":"314312331948766908","title":"Unknown","description":"The top GO terms are highly diverse (ubiquitination, cold response, calcium release, lipid catabolism, various differentiation and signaling processes, and endocytosis) with no clear shared function or pathway tying the proteins together. The absence of edges and cohesive themes suggests the cluster does not represent a single, interpretable biological role, so a concise, representative label cannot be assigned beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0051209","count":1},{"id":"GO:0046475","count":1},{"id":"GO:0035508","count":1}]},{"hash":"1554614098792258682","title":"Immune signaling regulation and cytotoxic granzyme production","description":"This cluster is enriched for GO terms related to modulation of immune signaling pathways (e.g., negative regulation of interleukin-2 signaling, TLR9 signaling, and p38 MAPK cascade) and processes affecting receptor signaling and cell adhesion, along with a term for positive regulation of granzyme B production, suggesting involvement in cytotoxic immune responses. The muramyl dipeptide response supports innate immune sensing, while some terms (like vestibular receptor morphogenesis) appear peripheral or as noise. Overall, the proteins likely participate in immune signaling regulation with cytotoxic potential.","confidence":"Medium","size":14,"edges":44,"triangles":68,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:1902206","count":2},{"id":"GO:2000646","count":2},{"id":"GO:0060116","count":2},{"id":"GO:0071225","count":2}]},{"hash":"897346001381412348","title":"Propeptide Processing and Hormone Maturation","description":"Most terms relate to processing and secretion of peptide hormones and growth factors: insulin processing, renin secretion, peptide pheromone maturation, dibasic protein processing, and nerve growth factor production. These processes involve proteolytic maturation of propeptides at dibasic sites to yield active peptides, suggesting a shared functional theme of peptide maturation and regulated release. A couple of terms (negative regulation of LDL receptor activity, zygotic axis determination) are less tightly connected and appear as noise relative to the core theme.","confidence":"Medium","size":14,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1905598","count":2},{"id":"GO:0002001","count":2},{"id":"GO:0030070","count":2},{"id":"GO:0007323","count":2},{"id":"GO:0010989","count":2}]},{"hash":"908325070291241631","title":"Antiviral innate immunity and NF-kappaB signaling","description":"The cluster is dominated by GO terms related to innate immune response (GO:0045087), defense response to virus (GO:0051607), and positive regulation of canonical NF-kappaB signal transduction (GO:0043123). Autophagy (GO:0006914) and regulation of ubiquitin-dependent protein catabolic processes (GO:2000059) reinforce a theme of antiviral defense and NF-kB\u2013mediated regulation, with autophagy often linked to immune responses. Some terms such as miRNA metabolic process and developmental processes are less directly connected but may reflect broader regulatory roles; nonetheless, the core signal points to antiviral innate immunity and NF-kappaB-driven responses.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0051607","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0051092","count":4},{"id":"GO:0006914","count":3}]},{"hash":"405558454276167953","title":"Neuronal Synaptic Function and Circadian Regulation","description":"Based on the top GO terms, the cluster is enriched for neuronal communication and circadian biology: glutamate secretion, synaptic vesicle endocytosis/uncoating, and limbic system development, along with circadian sleep/wake cycle terms. While there are general transcription/tRNA processing terms also present, the strongest signals point to synaptic transmission and circadian regulation, suggesting a cluster of neuronal signaling components with circadian context.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0042748","count":2},{"id":"GO:0021761","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0000722","count":1}]},{"hash":"212145255185649880","title":"Autophagy and Membrane Repair Regulators","description":"The cluster\u2019s top GO terms are dominated by autophagy and plasma membrane repair, pointing to a core role in cellular stress responses related to membrane maintenance. Additional terms indicate broad regulatory functions (protein turnover, epigenetic programming, transcription factor activity), suggesting these proteins act as regulators coordinating membrane dynamics, autophagy, and gene expression, despite some outlier annotations likely reflecting noise. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0001778","count":4},{"id":"GO:0006914","count":3},{"id":"GO:1900458","count":3},{"id":"GO:2000059","count":3},{"id":"GO:0060669","count":3}]},{"hash":"1465700309264051813","title":"Neuronal Excitability and Synaptic Transmission","description":"The top GO terms are dominated by ion transport (potassium and sodium), membrane depolarization, excitatory postsynaptic potentials, and neuronal action potential propagation, which together point to proteins involved in generating and modulating neuronal electrical signaling and synaptic communication. A few terms related to cell adhesion or development appear but are not primary drivers of this cluster's theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0051899","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0070830","count":3}]},{"hash":"1331976153596769817","title":"Unknown","description":"The top terms are highly diverse, spanning innate immunity, metal stress, cell cycle, metabolism, neural development, transcription, and nuclear transport, with no single coherent function uniting them. This suggests a mixed or heterogeneous cluster rather than a specific, narrowly defined process.","confidence":"","size":14,"edges":13,"triangles":8,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0071276","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0006006","count":4},{"id":"GO:0021695","count":4}]},{"hash":"2137483789459830456","title":"Coagulation and ECM Remodeling with Immune Activation","description":"The predominance of GO terms like blood coagulation, hyaluronan metabolic process, cellular extravasation, heterotypic cell-cell adhesion, complement activation, and negative regulation of extracellular matrix assembly centers on vascular and extracellular matrix (ECM) dynamics, immune signaling, and protein turnover. This suggests a cohesive theme around coagulation, ECM remodeling, and immune interactions rather than a single plant-specific pathway, even though some terms (chlorophyll biosynthetic process, stamen formation) may reflect annotation noise or cross-species data. Confidence reflects the moderate alignment across several related processes, balanced against the plant-specific terms.","confidence":"Medium","size":14,"edges":25,"triangles":20,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":8},{"id":"GO:0030212","count":7},{"id":"GO:0045123","count":7},{"id":"GO:0034113","count":7},{"id":"GO:0006511","count":7}]},{"hash":"65004280822136493","title":"Plant cell wall development and seed mucilage biosynthesis","description":"Rationale: The top GO terms are dominated by plant-specific processes related to epidermal cell wall formation, including root hair development, cell wall organization, and seed coat mucilage biosynthesis, with a notable emphasis on hydroxyproline-based glycosylation typical of plant cell walls. A few terms are broader or cross-kingdom, but the prevailing signal is plant epidermal/cell wall biosynthesis. ","confidence":"Medium","size":14,"edges":21,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0080147","count":4},{"id":"GO:0071555","count":3},{"id":"GO:0042754","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0075015","count":2}]},{"hash":"820191788606196445","title":"Cytosolic/ER proteostasis and ribosome QC","description":"Based on GO terms for cytosolic ubiquitin-proteasome\u2013mediated protein quality control, ribosome-associated degradation, and ER-to-cytosol transport, the cluster appears to represent proteostasis and ribosome QC processes. Some terms are unrelated or archaic (e.g., menaquinone biosynthesis, AMP salvage), suggesting annotation noise, but the dominant signals point to proteostasis mechanisms.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0071712","count":2},{"id":"GO:0071629","count":2},{"id":"GO:0051974","count":2}]},{"hash":"152860139979762788","title":"Macrophage lipid clearance and apoptotic clearance","description":"The top GO terms center on macrophage lipid handling and clearance, including HDL particle clearance, foam cell differentiation, and apoptotic cell clearance, suggesting a macrophage-driven lipid clearance and phagocytosis role. Some transcription/biogenesis terms appear, but the dominant signals point to macrophage-associated lipid clearance and apoptotic cell removal.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051044","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0010983","count":2},{"id":"GO:0043277","count":2},{"id":"GO:2000172","count":2}]},{"hash":"1488733897690688089","title":"Keratinocyte inflammatory and wound-healing responses","description":"This cluster centers on keratinocyte differentiation and multiple inflammatory/wound-healing processes (negative/positive regulation of inflammation, prostaglandin signaling, IL-1\u03b2 regulation, calcium signaling, and coagulation), suggesting a skin barrier and immune response theme; a few terms (like visual perception) appear unrelated and may reflect annotation noise.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0050728","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0030216","count":3}]},{"hash":"470652353443633894","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:1902187","count":6},{"id":"GO:0007014","count":6},{"id":"GO:2000637","count":6},{"id":"GO:0045087","count":6}]},{"hash":"1867086796398113233","title":"Neural development and axon guidance","description":"This cluster is dominated by neural- and connectivity-related GO terms: nervous system development, axonal fasciculation, positive regulation of synapse assembly, and both heterophilic and homophilic cell-cell adhesion, all of which point to neuronal wiring and synapse formation. Additional terms like protein localization to the paranode region of the axon and trigeminal nerve development reinforce the emphasis on axon organization and cranial nerve development. While a few terms touch on ossification and endothelial signaling, the central theme is neural development and connectivity. High","confidence":"","size":14,"edges":12,"triangles":3,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0043931","count":5}]},{"hash":"1850732802581732025","title":"Unknown","description":"The GO terms are highly diverse and do not converge on a single biological process; they include regulation of IL-1\u03b2 production, calcium signaling, prostaglandin response, blood coagulation, vascular differentiation, viral chemokine suppression, grooming behavior, phototransduction, appetite regulation, and osmotic-stress\u2013related apoptosis. With no network edges or coherent functional theme linking the proteins, there isn\u2019t a clear, representative function to name the cluster.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":14},{"id":"GO:0051209","count":14},{"id":"GO:0071380","count":14},{"id":"GO:0007596","count":14},{"id":"GO:2000724","count":14}]},{"hash":"1978563507788780159","title":"Unknown","description":"The GO terms are highly diverse (oxidation-reduction, GM-CSF/EGF/glucocorticoid stimuli, prostaglandin biosynthesis, detoxification, pinocytosis regulation, cardiac relaxation, smell perception, LPS response) with no clear common function, and there are no edges among the proteins, so a cohesive, specific label cannot be determined.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0071364","count":2},{"id":"GO:0071385","count":2},{"id":"GO:0001516","count":2}]},{"hash":"2178729307799904912","title":"Unknown","description":"The top terms span RNA processing, transcription regulation, development, and stress responses with no single cohesive function tying them together; the mix includes RNA methylation, neural tube and skeletal development, rRNA maturation, and environmental responses, making a clear, specific label inappropriate.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0036265","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0000463","count":3}]},{"hash":"708937867073066568","title":"Unknown","description":"The top GO terms are diverse (cell motility regulation, Notch signaling, integrin signaling, dendritic cell activation, retina vasculature development, LDL response, and virion attachment), and with zero edges among the proteins there\u2019s no clear, cohesive functional theme linking them. This suggests the cluster does not represent a single, interpretable biological function rather than a miscellaneous collection. ","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000145","count":1},{"id":"GO:1901223","count":1},{"id":"GO:2001046","count":1},{"id":"GO:0046813","count":1},{"id":"GO:0043128","count":1}]},{"hash":"1751257899285371877","title":"Synaptic Transmission Regulation and Drug Response","description":"The top GO terms point to modulation of synaptic activity (both negative and positive regulation of glutamatergic transmission), sensory processing and learning (visual learning, prepulse inhibition, regulation of sensory perception of pain), and responses to drugs (morphine, amphetamine). The presence of potassium ion transport also fits neuronal excitability. One outlier term about cell wall macromolecule catabolic process likely reflects annotation noise rather than a core feature of the cluster. Overall, the proteins co-cluster around neural signaling and drug-response functions.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":2},{"id":"GO:0051967","count":2},{"id":"GO:0043278","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0051930","count":2}]},{"hash":"471958870833290221","title":"Membrane dynamics and vesicle trafficking","description":"The cluster centers on terms tied to membrane repair, vesicle transport along actin filaments, and other membrane-associated processes, with additional hints from cell polarity and organelle inheritance (bud neck, centrosome localization) and signaling pathways (VEGF, thrombin receptor) that influence cell movement and division. This suggests a cohesive theme around membrane dynamics and trafficking driving polarity and inheritance.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070493","count":4},{"id":"GO:0001778","count":4},{"id":"GO:0097271","count":3},{"id":"GO:0021873","count":3},{"id":"GO:0051661","count":3}]},{"hash":"456656858590136318","title":"Embryonic organogenesis and axis patterning","description":"The top GO terms cluster around development of multiple organs (heart, inner ear, cochlea, uterus) and anterior/posterior axis specification, with regulation of the Wnt signaling pathway. This points to a cohesive theme of embryonic organogenesis and body patterning, with Wnt signaling as a key axis, though a few terms may reflect ancillary vascular or endocrine roles.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0048839","count":2},{"id":"GO:0009952","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0090103","count":2}]},{"hash":"1017907016993843352","title":"Skeletal ECM Remodeling and Ossification","description":"This cluster shows strong hints of extracellular matrix organization, bone development, and ossification (GO:0030198, GO:0060348, GO:0001503), with proteoglycan cross-linking (GO:0019800) and angiogenesis regulation (GO:0045765) also represented. Together these terms point to proteins involved in skeletal extracellular matrix construction and mineralization, i.e., bone formation and ECM remodeling. Some terms (e.g., CNS development, antibacterial peptide regulation) may reflect pleiotropic roles of ECM components or incidental associations, but the dominant signal is skeletal ECM dynamics. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0030198","count":3},{"id":"GO:0007417","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0001970","count":3},{"id":"GO:0045765","count":3}]},{"hash":"760286392676283901","title":"Developmental Signaling and Morphogenesis","description":"The cluster includes GO terms tied to developmental processes and tissue formation, such as fertilization, angiogenesis, Hedgehog signaling (Smoothened), visual perception, skin development, and axon guidance, suggesting a common theme of developmental signaling and morphogenesis. There are also terms related to cellular stress and mitophagy, which can accompany remodeling during development, but the strongest pattern is developmental signaling and organogenesis. Confidence: Medium","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":2},{"id":"GO:0002042","count":2},{"id":"GO:0045880","count":2},{"id":"GO:0035694","count":2},{"id":"GO:0033554","count":2}]},{"hash":"845976972817384891","title":"Ribosome biogenesis and cytoplasmic translation","description":"This cluster is dominated by GO terms for translation, ribosome biogenesis (both small and large subunits), and maturation of rRNA, plus cytoplasmic translation and related assembly steps, pointing to a set of proteins involved in ribosome production and protein synthesis. A couple of terms like gastrulation and cellular fusion are less representative.","confidence":"High","size":13,"edges":51,"triangles":100,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0042273","count":2}]},{"hash":"1222245232085782553","title":"Actin Remodeling and MAPK Signaling","description":"The top GO terms cluster around actin cytoskeleton dynamics (dendritic spine development, lamellipodium/podosome assembly) and signaling pathways (small GTPase\u2013mediated signaling, ERK1/2 cascade). This points to proteins involved in cytoskeletal remodeling tied to MAPK signaling, with a few trafficking or cytokine-response terms appearing as ancillary connections.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060999","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0071803","count":3}]},{"hash":"1566923218084667572","title":"Cardiac conduction and endothelial adhesion","description":"These proteins appear enriched for cardiovascular development and cell\u2013cell adhesion: ventricular action potential regulation and His\u2013Purkinje adhesion reflect heart conduction, while cadherin-mediated adhesion and endothelial barrier establishment point to vascular and epithelial tissue organization. Nephron tubule differentiation hints at broader organ development. Together, the cluster likely represents cardiovascular/vascular development with adhesion signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0098911","count":3},{"id":"GO:0086073","count":3},{"id":"GO:0071681","count":3},{"id":"GO:0048023","count":2}]},{"hash":"977833148890069634","title":"Nuclear mRNA Splicing and Translation Initiation","description":"The top GO terms are dominated by splicing-related processes (splicesome-mediated mRNA processing, small-subunit processome assembly) and mRNA export, with additional signals for translation initiation complex assembly and IRES-dependent translation. This points to a cluster of proteins involved in nuclear RNA processing and the initiation of translation, with some links to RNA-mediated gene regulation under stress. Confidence: High","confidence":"","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0010610","count":7},{"id":"GO:0006378","count":7},{"id":"GO:0045292","count":7}]},{"hash":"833227882368652028","title":"Embryonic development and organ morphogenesis","description":"The top GO terms cluster around embryonic and neural development, including neural plate development, embryonic body morphogenesis, kidney vesicle formation, midbrain dopaminergic neuron differentiation, and heart-related tissue organization. Additional terms point to chromatin regulation and nuclear import, consistent with gene-expression programs driving development. An outlier term about host-symbiont response is present but does not dominate the theme. ","confidence":"Medium","size":13,"edges":69,"triangles":204,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":8},{"id":"GO:0001840","count":5},{"id":"GO:1904948","count":5},{"id":"GO:1904501","count":5},{"id":"GO:0006607","count":5}]},{"hash":"1423238058474092632","title":"TLR-driven innate immunity and inflammation","description":"The cluster\u2019s top GO terms center on innate immune sensing (lipopolysaccharide detection, TLR10 signaling), macrophage activation and dendritic cell cytokine regulation, and inflammatory response. These collectively indicate a group of proteins involved in initiating and propagating immune responses to bacterial components, with emphasis on TLR-mediated pathways and inflammatory signaling. A few terms about chromatin localization or actin remodeling may be ancillary, but the dominant theme is innate immune activation.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":3},{"id":"GO:0032497","count":2},{"id":"GO:0002730","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0042116","count":2}]},{"hash":"1206061688115425882","title":"Cholesterol-Dependent Neural and Epidermal Development","description":"The terms cluster around cholesterol metabolism (regulation and homeostasis) and developmental signaling affecting neural and epidermal lineages, including smoothened signaling in neural tube patterning, spinal cord motor neuron differentiation, epidermal cell differentiation, and keratinocyte proliferation. This suggests a shared theme where cholesterol-related signaling intersects with Hedgehog/Smoothened pathways to drive neural and skin development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":2},{"id":"GO:0043407","count":1},{"id":"GO:0045606","count":1},{"id":"GO:0021522","count":1},{"id":"GO:0072203","count":1}]},{"hash":"299008085059724733","title":"Cardiac GPCR Signaling and Energy Metabolism","description":"The cluster centers on GPCR-mediated signaling (adenylate cyclase activation, GPCR signaling, opsin-related signaling) with downstream phosphorylation and GTPase regulation, and includes heart-related terms (heart development, blood pressure). The electron transport chain term adds an energy metabolism aspect, fitting a cardiovascular signaling and metabolic module. ","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":12},{"id":"GO:0008284","count":11},{"id":"GO:0010579","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0043547","count":11}]},{"hash":"16688648433906626","title":"Dopamine and Adrenergic GPCR-cAMP Signaling","description":"The cluster is dominated by GO terms for GPCR signaling that activates adenylyl cyclase and increases cAMP, including dopamine receptor signaling and adrenergic receptor signaling. Related terms point to broader signaling roles (PI biosynthesis, GTPase regulation) and physiological outcomes like thermogenesis and heart-related signaling, all consistent with catecholamine-mediated GPCR-cAMP pathways.","confidence":"High","size":13,"edges":33,"triangles":6,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0007603","count":8},{"id":"GO:0007507","count":8}]},{"hash":"1607083471275974560","title":"Neural development and dopaminergic neuron differentiation","description":"The top GO terms cluster around neural development, especially neural plate development and midbrain dopaminergic neuron differentiation, which points to roles in neural fate specification and maturation. Additional terms cover neurogenesis-related processes such as cell cycle regulation, apoptosis, cell migration, and centrosome separation, with Wnt signaling modulation aligning with neural patterning. Overall, this cluster seems to coordinate neural development with dopaminergic neuron differentiation.","confidence":"High","size":13,"edges":56,"triangles":126,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":6},{"id":"GO:0007050","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0043065","count":4},{"id":"GO:0015991","count":4}]},{"hash":"56962589049299816","title":"Fatty acid oxidation and carnitine metabolism","description":"The top GO terms are dominated by fatty acid beta-oxidation and the carnitine metabolic process, suggesting enzymes involved in lipid-derived energy production. Some related terms about adipose development or starvation support a metabolic-energy theme, though a few items appear noisy.","confidence":"Medium","size":13,"edges":10,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019254","count":2},{"id":"GO:0033540","count":2},{"id":"GO:0042595","count":1},{"id":"GO:0006471","count":1}]},{"hash":"1957423752795749966","title":"Neural crest migration and axon guidance","description":"The top terms cluster around neural crest\u2013derived cell migration and axon guidance, including ventral trunk neural crest migration, trigeminal nerve organization, branchiomotor neuron axon guidance, sympathetic neuron projection guidance/extension, and semaphorin-plexin signaling, with supporting heterophilic adhesion. This points to a cohesive neural development theme focused on migration and axon pathfinding.","confidence":"High","size":13,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":5},{"id":"GO:0002042","count":5},{"id":"GO:0021637","count":4},{"id":"GO:0097491","count":4},{"id":"GO:0097490","count":4}]},{"hash":"42493226209279471","title":"Genome maintenance and protein homeostasis","description":"The cluster contains DNA replication and recombination terms, pointing to genome maintenance, alongside protein folding/trafficking and stress-regulation terms, suggesting a link to cellular protein quality control and stress response. Together, these signals indicate a theme of preserving genome and proteome integrity under stress.","confidence":"Medium","size":13,"edges":25,"triangles":13,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0070389","count":3},{"id":"GO:0031204","count":3},{"id":"GO:1900035","count":3},{"id":"GO:0090084","count":3}]},{"hash":"481825888727742780","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms for translation, ribosome biogenesis, cytoplasmic translation, and ribosomal subunit export from the nucleus, pointing to proteins involved in ribosome assembly and protein synthesis. The presence of cell cycle and cell division terms may reflect coordination with growth and proliferation, but the central theme remains ribosome-related processes.","confidence":"Medium","size":13,"edges":51,"triangles":95,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0007049","count":4},{"id":"GO:1901001","count":3},{"id":"GO:1903833","count":3}]},{"hash":"102243564644066217","title":"Ubiquitin-Dependent Autophagy and NF-\u03baB Regulation","description":"These proteins cluster around ubiquitin-mediated processes (autoubiquitination, ubiquitin-dependent degradation), autophagy, and inflammatory signaling (NF-\u03baB, TNF). The shared GO terms suggest a cohesive role in protein turnover via ubiquitination coupled with autophagic and NF-\u03baB\u2013mediated regulatory pathways, indicating a specific functional module despite sparse interaction data.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:1901253","count":3},{"id":"GO:1903762","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0042787","count":3}]},{"hash":"1999747876424302918","title":"Steroid Hormone Biosynthesis and Metabolism","description":"The top GO terms are dominated by steroid hormone biosynthesis and metabolism (estrogen, testosterone, glucocorticoids, C21-steroid hormone processes) along with steroid biosynthetic and catabolic activity. A few additional terms (very long-chain fatty acid biosynthesis; sporulation) appear but are less central. Taken together, the cluster likely represents enzymes and factors involved in steroidogenesis and hormone metabolism.","confidence":"High","size":13,"edges":25,"triangles":12,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008207","count":9},{"id":"GO:0006703","count":9},{"id":"GO:0042761","count":9},{"id":"GO:0006710","count":9},{"id":"GO:0061370","count":9}]},{"hash":"1550972893472455393","title":"Sensory perception and signaling","description":"The Top Terms show a clear emphasis on sensory processes (pain, visual perception/learning) and responses to stimuli (temperature, prostaglandin, morphine), with protein phosphorylation indicating signaling activity. Though there are outliers like heart development and macrophage chemotaxis, the strongest shared theme across the cluster is sensory perception and related signaling pathways. ","confidence":"Medium","size":13,"edges":63,"triangles":164,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0007601","count":7},{"id":"GO:0071380","count":6}]},{"hash":"1765070532198184065","title":"Neural and sensory organ development","description":"This cluster is dominated by GO terms related to neural and sensory tissue morphogenesis and differentiation\u2014axonogenesis, axon fasciculation, optic nerve and compound eye photoreceptor differentiation, and vestibular receptor morphogenesis\u2014suggesting a cohesive theme of neural/sensory development, despite a few outlier terms. ","confidence":"Medium","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":9},{"id":"GO:1902960","count":9},{"id":"GO:0001751","count":9},{"id":"GO:1904238","count":9},{"id":"GO:0021631","count":9}]},{"hash":"658169363075309022","title":"Embryonic and male reproductive development regulation","description":"This cluster centers on developmental regulation, especially embryogenesis and male reproductive tissue formation. Terms include in utero embryonic development, sclerotome development, male gonad development, and regulation of prostate gland morphogenesis, with supporting BMP signaling regulation and prostaglandin response signals, suggesting a cohesive developmental signaling module.","confidence":"Medium","size":13,"edges":27,"triangles":14,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:1904684","count":2},{"id":"GO:0045671","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0050732","count":2},{"id":"GO:0008584","count":2}]},{"hash":"840623041812058537","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":9,"triangles":1,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0010610","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0090503","count":3}]},{"hash":"189110877042912451","title":"Mitotic cell cycle regulation and APC-dependent proteolysis","description":"The strongest signals are cell division, mitotic cell cycle, and anaphase-promoting complex\u2013dependent catabolic process, plus K11-linked ubiquitination, pointing to coordinated control of mitosis via APC-mediated protein degradation. Other terms show broader signaling responses (LPS, vitamin D, estradiol) and angiogenesis, which may reflect secondary or context-specific connections but do not redefine the core theme. Overall, the cluster centers on mitotic regulation and targeted proteolysis.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0031145","count":2}]},{"hash":"67378631959668985","title":"GPCR-AC-PKC Signaling in Physiological Regulation","description":"The terms cluster around G protein-coupled receptor signaling, especially adenylate cyclase activation and PKC pathways, with downstream physiological effects including blood pressure regulation, renal sodium excretion, and smooth muscle contraction; a few outliers like electron transport and photoreceptor maintenance are less directly connected but may reflect broader cellular signaling contexts.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070528","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0045777","count":3}]},{"hash":"665357103493533655","title":"ER stress response and protein folding quality control","description":"The top GO terms cluster around unfolded protein response, ER stress-induced apoptosis regulation, chaperone-assisted protein folding, and SRP-dependent cotranslational targeting to membranes, pointing to protein quality control in the secretory pathway and stress signaling. A few terms (e.g., DNA replication) appear less representative, likely outliers. Overall, the dominant theme is managing misfolded proteins and ER stress.","confidence":"High","size":13,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0090084","count":4},{"id":"GO:1903382","count":4},{"id":"GO:0006880","count":4},{"id":"GO:0016226","count":4}]},{"hash":"454939735500612885","title":"Stress-Activated Translation and Spliceosome Components","description":"This cluster blends RNA processing (spliceosomal snRNP assembly and spliceosome catalytic steps) with translational regulation under stress signals (GCN2-mediated signaling; translation initiation in response to starvation; responses to UV-C and oxidative stress). The co-occurrence of splicing machinery terms with translation- and stress-related GO terms suggests a coherent module where RNA processing factors and stress-induced translational control are co-regulated.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000387","count":1},{"id":"GO:0000349","count":1},{"id":"GO:0060733","count":1}]},{"hash":"480686588493437532","title":"Leukocyte Activation and Trafficking","description":"The cluster is dominated by immune-related terms: leukocyte tethering/rolling, phagocytosis recognition, basophil activation, NK cell chemotaxis regulation, and arachidonate (inflammatory lipid) secretion, indicating a core theme of immune cell activation and recruitment. A few developmental terms may reflect broader signaling contexts or overlap, but the primary signal remains leukocyte activation and trafficking.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":13},{"id":"GO:0006910","count":13},{"id":"GO:0010572","count":13},{"id":"GO:0045575","count":13},{"id":"GO:0050901","count":13}]},{"hash":"1404061694331667349","title":"ER-Golgi trafficking and cell division with viral processing","description":"This cluster shows strong signals for ER to Golgi vesicle transport and inter-Golgi transport, along with cell division-related terms (DNA-templated transcription and mitotic sister chromatid separation). The presence of viral process and viral protein processing terms suggests viral interactions or processing, and several terms relate to proteasomal protein degradation. Taken together, the dominant theme seems to be vesicle trafficking coupled with cell cycle roles, with some viral processing context.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0016032","count":2},{"id":"GO:0051306","count":2}]},{"hash":"3771765556468619","title":"Hormone Signaling and Cell Cycle Regulation","description":"The top GO terms point to regulatory signaling pathways (regulation of GPCR signaling; steroid hormone receptor complex assembly; male sex differentiation) alongside cell cycle control (metaphase/anaphase transition). While a few terms touch on metabolism or other processes, the dominant theme across the cluster is hormonal signaling intertwined with regulation of cell division.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008277","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0090526","count":3},{"id":"GO:0006478","count":3},{"id":"GO:1902391","count":3}]},{"hash":"125548173502542648","title":"Nervous System and Eye Morphogenesis","description":"The cluster shows strong enrichment for neural/visual development terms, including protein localization to the paranode region of the axon, compound eye photoreceptor cell differentiation, and optic nerve morphogenesis, indicating a shared function in nervous system and visual system development. While a few terms touch on broader differentiation (e.g., pericyte differentiation, nephric duct morphogenesis), the prominent themes point to neurodevelopment and eye morphogenesis as the core of this protein group.","confidence":"High","size":13,"edges":72,"triangles":228,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":12},{"id":"GO:1902948","count":12},{"id":"GO:1902771","count":12},{"id":"GO:1902997","count":12},{"id":"GO:1902955","count":12}]},{"hash":"792269169220633563","title":"Ubiquitin-Proteasome System","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes, including polyubiquitination, SCF-dependent proteasomal degradation, ERAD, and autoubiquitination, with additional links to ubiquitin-related signaling (TNF/JNK). This strongly indicates proteins functioning in tagging substrates for degradation via the ubiquitin-proteasome system, so the name reflects the core theme of ubiquitination-driven proteolysis.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0000209","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0085020","count":5}]},{"hash":"681902115153957684","title":"Vertebrate neural and sensory development","description":"This cluster centers on neural development (PNS and motor neuron differentiation) and sensory organ formation (eye, inner ear), plus embryonic patterning events (primitive streak, anterior/posterior specification), with transcriptional regulation. Together these terms point to vertebrate neural and sensory system development and patterning as the common theme.","confidence":"High","size":13,"edges":14,"triangles":2,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0048935","count":8},{"id":"GO:0090009","count":8},{"id":"GO:0048839","count":7},{"id":"GO:0021524","count":6}]},{"hash":"1650211754062238088","title":"Unknown","description":"The top GO terms span skeletal development (bone mineralization, endochondral ossification), immune regulation (humoral response, B cell differentiation), adhesion (cadherin-mediated cell-cell adhesion), apoptosis (release of cytochrome c), and various developmental processes (implantation, vascular smooth muscle proliferation, imaginal disc eversion). The functions are diverse with no clear single theme or cohesive pathway, and there are no network edges to tie them together, so a generalized Unknown label is most appropriate.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030282","count":2},{"id":"GO:0001958","count":1},{"id":"GO:0002925","count":1},{"id":"GO:0044331","count":1},{"id":"GO:0090200","count":1}]},{"hash":"999934210916930728","title":"Neurodevelopment and axon guidance signaling","description":"This cluster is enriched for nervous system development, neurogenesis, myelination, and key signaling pathways such as Hedgehog (smoothened) and ROBO (Roundabout), suggesting a cohesive neural development and axon guidance module; other terms like kidney development and immune signaling are less central.","confidence":"High","size":13,"edges":76,"triangles":265,"max_degree":12,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007224","count":8},{"id":"GO:0035385","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0001822","count":7},{"id":"GO:0050852","count":7}]},{"hash":"771529958127797181","title":"Lung branching morphogenesis and ECM remodeling","description":"Most terms point to development and morphogenesis of the lung, notably epithelial tube branching and branching morphogenesis in the lung, and collagen catabolic/ECM remodeling processes. While other terms (bone ossification, thyroid hormone response, neuropeptide catabolic processes, and T cell activity) appear, the strong clustering around lung development and extracellular matrix remodeling suggests the core theme is lung morphogenesis and associated tissue remodeling.","confidence":"Medium","size":13,"edges":69,"triangles":216,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":11},{"id":"GO:0060448","count":11},{"id":"GO:0035593","count":11},{"id":"GO:0001957","count":11},{"id":"GO:2000179","count":11}]},{"hash":"1627022756289448691","title":"Neuronal adhesion signaling and ion transport","description":"The cluster shows enrichment in neuron-focused processes: reelin signaling, neuronal action potential propagation, and integrin-mediated signaling tied to cell-matrix adhesion and actin dynamics, plus calcium and potassium ion transport. These themes point to neuronal connectivity and excitability, modulated by adhesion and cytoskeletal remodeling. Some terms (vasculogenesis, LDL response) are more general but do not overwhelm the dominant neural signaling and adhesion pattern.","confidence":"Medium","size":13,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":3},{"id":"GO:0070588","count":3},{"id":"GO:0038026","count":2},{"id":"GO:0071404","count":2},{"id":"GO:0007160","count":2}]},{"hash":"624035188924543652","title":"Proteostasis and transcription regulation","description":"This cluster's most represented GO terms are ubiquitin-dependent protein catabolic process and DNA-templated transcription, which point to roles in protein degradation and gene expression control. While other terms touch on development, signaling, and immune response, they do not define a single cohesive pathway beyond general cellular regulation. Thus, a concise label focusing on proteostasis and transcriptional control captures the core theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0006351","count":3},{"id":"GO:2000584","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0048839","count":2}]},{"hash":"1170397978908610571","title":"Ribosome Biogenesis and Translation","description":"The top GO terms overwhelmingly reference ribosome assembly and protein synthesis (translation, ribosome biogenesis, small subunit biogenesis, rRNA maturation). This points to a core function in ribosome production and function. Some cell cycle and developmental terms appear as secondary associations, but the dominant theme is ribosome-related processes.","confidence":"High","size":13,"edges":28,"triangles":17,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0071447","count":3},{"id":"GO:0001843","count":2}]},{"hash":"1874135033834522394","title":"Neural development and GABAergic synapses","description":"The cluster\u2019s dominant GO terms center on nervous system development and synaptic activity, notably GABAergic transmission and synapse assembly, pointing to neural differentiation and inhibitory signaling. Related terms like inner ear development support a neural/tinued tissue context, while ossification and keratinization appear less central. Overall, the group seems tied to neural development with inhibitory synaptic signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0051932","count":2},{"id":"GO:0031424","count":2}]},{"hash":"1380124805419189539","title":"Mitotic Regulation and Ribosome Biogenesis","description":"The cluster is dominated by mitosis- and cell division-related GO terms (cell division; mitotic cell cycle; anaphase-promoting complex-dependent catabolic process) and by ubiquitination and chromatin modification processes (K11-linked ubiquitination; histone methylation). In addition, ribosome biogenesis is indicated by box C/D snoRNP assembly and maturation of LSU rRNA, suggesting coordination between cell cycle progression and ribosome assembly. A few terms like cellular response to cadmium ion appear as secondary stress responses, but the core signal points to mitotic control coupled with ribosome biogenesis.","confidence":"High","size":13,"edges":61,"triangles":148,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1748920453823263041","title":"Neural Sensory Signaling and Behavioral Responses","description":"The proteins appear to participate in neural signaling and sensory-response pathways. Dominant terms include sensory perception of pain, behavioral response to cocaine, visual learning, and responses to temperature and prostaglandin stimuli, all tied to neuronal signaling (calcium release and ERK cascade regulation). Although a few terms relate to heart development and thermogenesis, the common link is signaling-driven responses to external stimuli in neural circuits.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0051209","count":7},{"id":"GO:0071380","count":7},{"id":"GO:0008542","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1181833580947597670","title":"Endochondral ossification and cartilage development","description":"The cluster shows multiple GO terms tied to skeletal cartilage formation, including endochondral ossification, cartilage condensation, and growth plate chondrocyte development, suggesting a primary focus on cartilage/bone development. While immune-related terms like complement activation and adaptive immune response appear among the top terms, they are less central to the cluster\u2019s main function.","confidence":"Medium","size":13,"edges":76,"triangles":264,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0045162","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0001958","count":1}]},{"hash":"310152790749934245","title":"Hemidesmosome Assembly and Adhesive Signaling","description":"The top terms highlight adhesion-related processes (hemidesmosome assembly, substrate adhesion-dependent cell spreading, receptor clustering) and signaling regulation (protein tyrosine kinase activity), pointing to a cohesive theme of cell\u2013matrix adhesion and junctional signaling. Additional vascular permeability and migration terms support a broader context of barrier-associated adhesion dynamics, while apoptotic/Notch terms likely reflect signaling cross-talk rather than core function. Confidence: Medium","confidence":"","size":13,"edges":15,"triangles":2,"max_degree":7,"top_function":"wound healing","top_go_terms":[{"id":"GO:0061097","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0043116","count":4},{"id":"GO:0034446","count":4},{"id":"GO:0031581","count":4}]},{"hash":"1910226182389690711","title":"Developmental signaling and tissue morphogenesis","description":"This cluster centers on developmental processes across multiple tissues, including heart and nervous system development, angiogenesis, and axon guidance, coupled with several signaling pathways (Hedgehog via Smoothened, Slit-Robo, STAT phosphorylation, and NF-kappaB). While a few terms (e.g., mast cell chemotaxis) are less core, the overarching theme is developmental signaling and morphogenesis across cardiovascular and nervous systems.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0002551","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0042511","count":4},{"id":"GO:0007507","count":4}]},{"hash":"64461999436214609","title":"Immune Activation and Cell Adhesion","description":"Based on the most frequent GO terms, this cluster centers on immune cell communication and activation: heterophilic cell-cell adhesion, T cell co-stimulation, dendritic cell differentiation, IL-4 production, and NK cell\u2013mediated cytotoxicity. While there are a few development-related terms (pronephric glomerulus, larval muscle) and a spermatid differentiation term, these are less represented, so the dominant signal is immune signaling and cell-contact processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0031295","count":3},{"id":"GO:0070059","count":2},{"id":"GO:0039021","count":2}]},{"hash":"1792746032368358799","title":"Cell fate signaling and transcriptional regulation","description":"This cluster concentrates on core signaling pathways (Wnt, Hippo, T cell receptor) and downstream transcriptional programs, plus related apoptotic and differentiation processes, with immune-stimulus responses (LPS, GM-CSF) reinforcing a theme of cell fate decisions governed by signaling and gene regulation.","confidence":"High","size":13,"edges":72,"triangles":227,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":10},{"id":"GO:0060044","count":10},{"id":"GO:0071222","count":10},{"id":"GO:0090263","count":10},{"id":"GO:0050852","count":10}]},{"hash":"553046983509088125","title":"Growth, Metabolism, and Development Network","description":"The top GO terms span metabolic processes (fatty acid beta-oxidation, L-alanine, L-kynurenine catabolism), developmental signaling (Notch pathway) and organ development (liver, adipose), along with core processes like DNA replication and transcription. This mix suggests proteins that connect metabolic activity with growth and tissue development rather than a single, narrow function. The label reflects a broad regulatory hub linking metabolism and development.","confidence":"Medium","size":13,"edges":55,"triangles":149,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006635","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0042853","count":3}]},{"hash":"1381482403652919180","title":"ER Stress Response and Protein Folding","description":"The dominant term is cellular response to unfolded protein, with SRP-dependent cotranslational targeting to the ER, pointing to ER protein folding and quality control; negative regulation of ER-stress\u2013related apoptotic signaling reinforces this theme. Some terms (iron-sulfur cluster assembly, beta-glucan biosynthesis) seem ancillary or noisy but do not override the core ER-centric pattern.","confidence":"High","size":13,"edges":36,"triangles":38,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":4},{"id":"GO:1903382","count":4},{"id":"GO:0006880","count":4},{"id":"GO:0016226","count":4},{"id":"GO:0034620","count":4}]},{"hash":"1214693938940624978","title":"Arabinogalactan protein glycosylation and plant development","description":"This cluster centers on arabinogalactan proteins (AGPs) and related glycosylation processes (e.g., hydroxyproline O-glycosylation, poly-N-acetyllactosamine, Lewis a epitopes) and plant-specific developmental events such as root hair formation and seed coat mucilage biosynthesis, indicating a theme of plant cell surface glycoprotein modification and its role in development.","confidence":"High","size":13,"edges":36,"triangles":30,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0075015","count":5},{"id":"GO:0042248","count":4},{"id":"GO:0030311","count":4},{"id":"GO:0048354","count":4},{"id":"GO:0080147","count":4}]},{"hash":"1822181156508028037","title":"Unknown","description":"The 13 proteins show highly diverse GO terms, including transcription regulation, translation (mitochondrial), development (cardiac and cartilage), and metabolism (dUMP and triglycerides). There is no single unifying function or pathway that predominates; thus a cohesive, specific label cannot be assigned.","confidence":"","size":13,"edges":75,"triangles":255,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045618","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0003231","count":1},{"id":"GO:1903779","count":1},{"id":"GO:0046079","count":1}]},{"hash":"1809412332365376144","title":"Integrin-Driven Angiogenesis and ECM Remodeling","description":"The cluster is dominated by terms tied to angiogenesis and vascular remodeling, including integrin-mediated signaling, endothelial cell migration, and ERK cascade regulation. Hyaluronan metabolism and metallopeptidase activity point to extracellular matrix remodeling that supports new vessel formation, while PDGF receptor signaling adds a growth-factor signaling layer. Collectively, these terms describe an angiogenic program centered on integrin signaling and ECM dynamics; a minor component like response to fungal origin may reflect broader immune-vascular interactions but does not define the main theme.","confidence":"High","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007229","count":9},{"id":"GO:0071226","count":8},{"id":"GO:0030212","count":7},{"id":"GO:1905050","count":7},{"id":"GO:0010641","count":7}]},{"hash":"1615662289521418299","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007014","count":6},{"id":"GO:0018032","count":6},{"id":"GO:2000637","count":6},{"id":"GO:1903886","count":6},{"id":"GO:0072089","count":6}]},{"hash":"1661602249825669820","title":"Angiogenesis and vascular development signaling","description":"The cluster shows a clear emphasis on angiogenesis and vascular formation, with terms like angiogenesis, positive regulation of endothelial cell migration, and mesoderm formation, plus signaling pathway involvement such as ERK1/ERK2 cascade. There are also non-cohesive terms like lipopolysaccharide biosynthesis that may reflect noise or multi-functional proteins, but the dominant signal points to vascular development and angiogenic regulation. Confidence is medium.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0071374","count":2},{"id":"GO:0048680","count":2},{"id":"GO:0043536","count":2}]},{"hash":"1195678611133919149","title":"AGP Glycosylation and Root Hair/Mucilage Biosynthesis","description":"GO terms point to arabinogalactan protein metabolic and glycosylation processes (poly-N-acetyllactosamine, Lewis a epitope), plus root hair development and seed mucilage biosynthesis, suggesting a plant cell-surface glycoprotein program central to AGP biosynthesis and function. Some terms are less directly linked (e.g., insect visual primordium formation), but the dominant pattern supports this theme.","confidence":"High","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":4},{"id":"GO:0075015","count":3},{"id":"GO:0080147","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0042248","count":2}]},{"hash":"1354236742675713046","title":"Unknown","description":"The Top Terms cover a wide and seemingly unrelated mix of processes (immune/inflammatory regulation, calcium signaling, prostaglandin response, coagulation, vascular differentiation, behavior, phototransduction, appetite regulation, and osmotic-stress\u2013related apoptosis). There isn\u2019t a single coherent biological theme tying these proteins together, so a precise functional label isn\u2019t supported.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":13},{"id":"GO:0051209","count":13},{"id":"GO:0071380","count":13},{"id":"GO:0007596","count":13},{"id":"GO:2000724","count":13}]},{"hash":"774738787411434136","title":"Cell cycle regulators and division proteins","description":"The top GO terms are dominated by cell cycle and cell division (GO:0007049 and GO:0051301), indicating the core function of this cluster centers on progression through the cell cycle and mitosis. Other terms such as chloroplast targeting and various signaling or stress-related processes appear auxiliary or annotation-noise, so the main theme remains cell-cycle related. Hence the label reflects the most represented function across the proteins. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0007049","count":5},{"id":"GO:1900383","count":4},{"id":"GO:1901187","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0048265","count":3}]},{"hash":"1211586823298282771","title":"Axon guidance and synaptic signaling","description":"This cluster is enriched for terms related to neuronal development and synaptic function, including axonal fasciculation and axon extension (axonal guidance) and neurotransmission components like potassium/sodium transport, excitatory postsynaptic potential, and GABA signaling. Although a small subset includes NF-kappaB signaling and defense responses, the dominant pattern points to axon guidance and synaptic activity, hence this label.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007413","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0071805","count":4},{"id":"GO:0001661","count":4},{"id":"GO:0035725","count":4}]},{"hash":"1182443065680919079","title":"Nervous system development and axon guidance","description":"Most of the top GO terms are about neural development and signaling\u2014axon guidance (dorsal/ventral), Schwann cell development, retina development, neuronal-glial interactions, and cholinergic GPCR signaling\u2014indicating a cluster enriched for nervous-system patterning and synaptic communication. A few terms pertain to other organ morphogenesis, but the dominant theme is neural development and axon guidance. ","confidence":"Medium","size":13,"edges":45,"triangles":43,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:1905815","count":3},{"id":"GO:0072249","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0032224","count":3},{"id":"GO:0014044","count":3}]},{"hash":"1634178006705517049","title":"Synaptic vesicle trafficking and endocytosis","description":"This cluster groups proteins involved in the full cycle of synaptic vesicle life, including endocytosis, synaptic vesicle recycling, and various vesicle transport routes (anterograde and retrograde) between presynaptic zones, endosomes, Golgi, ER, and related compartments. The terms reflect a cohesive vesicle trafficking program in neurons, reinforced by the neuronal development term for Purkinje cells, suggesting a neural context for synaptic vesicle dynamics.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036465","count":1},{"id":"GO:0021691","count":1},{"id":"GO:0030100","count":1},{"id":"GO:0006897","count":1},{"id":"GO:0048490","count":1}]},{"hash":"1470890694582087223","title":"Auditory and sensory system development","description":"Most prominent terms are related to auditory and sensory development and perception: auditory receptor cell development, detection of mechanical stimulus involved in sensory perception of sound, and development of the principal sensory nucleus of the trigeminal nerve. These suggest a common theme around sensory system development, particularly hearing and somatosensory pathways. The remaining GO terms appear ancillary (immune and signaling) and may reflect annotation noise or multifunctionality, but do not override the sensory signal.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0060117","count":2},{"id":"GO:0050910","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0035023","count":2}]},{"hash":"278937074117398378","title":"Meiosis and cell division with bud neck localization","description":"The top GO terms are dominated by cell cycle, cell division, and meiosis-related processes (cell cycle, spermatogenesis, meiotic metaphase chromosome alignment, cell division). Additionally, protein localization to the bud neck and conjugation with cellular fusion strongly point to yeast-like mating/division machinery. While a few terms touch on broader morphogenesis (embryonic cell shape, neuron projection development), the core theme ties to reproductive cell division and associated cellular localization. Confidence: High","confidence":"","size":13,"edges":4,"triangles":1,"max_degree":3,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0007049","count":5},{"id":"GO:0007283","count":5},{"id":"GO:0051311","count":4},{"id":"GO:0097271","count":4},{"id":"GO:0051301","count":4}]},{"hash":"2266776899460736904","title":"Unknown","description":"The top GO terms span very different areas (mitochondrial dynamics, eye development, antiviral/dsRNA responses, development, T cell chemotaxis, membrane targeting, and apoptotic signaling) with no clear shared function among the proteins. Without a cohesive theme, I cannot assign a meaningful label beyond Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090141","count":6},{"id":"GO:0043010","count":5},{"id":"GO:0032464","count":5},{"id":"GO:0002230","count":5},{"id":"GO:0007275","count":5}]},{"hash":"1218453347530300134","title":"Cardiac mechanotransduction and immune signaling","description":"This cluster highlights terms related to mechanical stimulus responses and SA node\u2013related cardiac signaling (cellular response to mechanical stimulus; regulation of SA node cell action potential), suggesting a mechanotransduction theme in cardiac tissue. It also includes immune-related terms (chemokine production, IL-12 regulation, NF-kappaB activity), indicating concurrent immune signaling involvement. The combination points to a mixed set of functions spanning cardiac mechanosensing and inflammatory regulation rather than a single, cohesive function. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":2},{"id":"GO:0045083","count":2},{"id":"GO:2000340","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0071651","count":2}]},{"hash":"674390647776858626","title":"Membrane signaling, endocytosis, and adhesion dynamics","description":"The cluster\u2019s GO terms are centered on signaling at the plasma membrane (GPCR and thrombin pathways, insulin signaling, prostaglandin response), membrane trafficking (clathrin-dependent endocytosis, GPCR internalization), and cytoskeletal/adhesion connections (Rho signaling, focal adhesion assembly, dynein-driven movement), suggesting a cohesive theme of membrane signaling coupled to trafficking and adhesion dynamics.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0030989","count":4},{"id":"GO:0048041","count":4},{"id":"GO:0070493","count":4},{"id":"GO:0010572","count":3}]},{"hash":"1898766512373995730","title":"Neural signaling and regulatory processes","description":"The cluster's terms strongly point to neural activity: excitatory postsynaptic potential, transmission of nerve impulse, and potassium ion transmembrane transport indicate neuronal signaling. Additional terms on mRNA processing and regulation of translational initiation by eIF2 alpha phosphorylation suggest post-transcriptional control, while innate immune response and skeletal development may reflect broader multifunctionality. Overall, the cluster most plausibly represents neural signaling plus associated regulatory processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0001954","count":2},{"id":"GO:0060079","count":2}]},{"hash":"227299398750019504","title":"Unknown","description":"The GO terms are highly diverse, spanning mechanical stimulus response, hormone and nutrient responses (vitamin D, glucocorticoid, cAMP), stress pathways (hypoxia, hydrogen peroxide), developmental processes (myoblast differentiation, adenohypophysis morphogenesis, cuticle development), and apoptosis regulation, with no single cohesive function tying the proteins together. This makes a single representative label unlikely.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0045445","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0008365","count":2}]},{"hash":"1887823700081582494","title":"Unknown","description":"The GO terms cover insect development (oskar mRNA translation regulation, posterior head segmentation, epithelial migration) and apoptosis, but also include bacterial cell wall processes (peptidoglycan turnover, muramic acid catabolic activity) and general metabolism, showing no single cohesive function for all proteins. This makes a confident, specific label impractical.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046011","count":1},{"id":"GO:1902108","count":1},{"id":"GO:0007427","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0035289","count":1}]},{"hash":"451592749067233389","title":"Calcium-Mediated Sensory Signaling","description":"This cluster centers on calcium ion release/regulation and signaling pathways (ERK cascade) with several sensory-related GO terms (visual perception, phototransduction, pain perception) suggesting a shared theme of stimulus-triggered signaling in sensory contexts, though some terms are broad and less directly linked.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0019233","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0007596","count":4}]},{"hash":"557190737983122390","title":"Unknown","description":"The terms span epigenetic modification, various tissue development processes (heart, uterine and tarsal glands, myotube), ciliary assembly/motility, immune signaling, and metabolism, with no single dominant function tying the proteins together. This broad, heterogeneous mix suggests there is no coherent theme for a specific cluster label.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097676","count":2},{"id":"GO:1903709","count":2},{"id":"GO:1903699","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0032635","count":2}]},{"hash":"2243825951295475523","title":"Vascular remodeling with innate immunity","description":"The top terms cluster around angiogenesis, endothelial cell migration, and vascular regulation, coupled with innate immune signaling (complement lectin pathway and pattern-recognition receptor signaling) and cell-matrix adhesion, suggesting a coordinated vascular-immune remodeling program.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035641","count":5},{"id":"GO:0001867","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0060244","count":3},{"id":"GO:0045766","count":3}]},{"hash":"1983035718122824181","title":"Embryonic morphogenesis and organogenesis","description":"This cluster centers on embryonic development and morphogenesis: gastrulation and convergent extension, organogenesis, pancreas development, cartilage condensation, and related growth regulation. The GO terms point to tissue patterning, cell migration, and growth control during development, suggesting a cohesive developmental program. ","confidence":"Medium","size":12,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0060770","count":1},{"id":"GO:0042074","count":1},{"id":"GO:0060028","count":1},{"id":"GO:0060215","count":1}]},{"hash":"23113868750539254","title":"Unknown","description":"The top GO terms span adaptive immune response, signaling (JNK cascade regulation), neuronal development (dendritic spine morphogenesis), yeast cell cycle processes (bud neck localization, septation signaling), DNA repair (preincision complex stabilization), histone ubiquitination, apoptotic regulation, and viral processes. This broad dispersion indicates no single cohesive function tying the cluster together, so a concise, representative label cannot be confidently assigned.","confidence":"","size":12,"edges":12,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0031030","count":1},{"id":"GO:0006293","count":1}]},{"hash":"357170709311374656","title":"Ion Transport and Vesicle Trafficking","description":"Proteins in this cluster are enriched for transmembrane ion transport (potassium and sodium) and intracellular trafficking processes (endosome-to-Golgi retrograde transport, lysosomal transport, dense core granule transport), plus some reproductive-related steps like acrosome assembly and spermatid development. This combination points to a common theme of membrane transport and vesicle trafficking, with some lineage-specific roles in reproduction. The label aims to reflect the dominant transport-oriented pattern without overfitting to a single process.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0042147","count":1},{"id":"GO:1904811","count":1},{"id":"GO:0007290","count":1}]},{"hash":"448579186176971883","title":"Cytoskeletal dynamics and membrane remodeling","description":"The top GO terms point strongly to cell movement and shape changes (regulation of fibroblast migration, regulation of filopodium assembly, membrane addition during cytokinesis) and membrane composition (phospholipid homeostasis) plus signaling (Rap-mediated pathways) and processes of morphogenesis (kidney size, cardiac conduction). Together, they suggest a cohesive function in cytoskeletal remodeling, cell migration, and membrane trafficking, rather than a single, narrow enzyme activity. ","confidence":"High","size":12,"edges":20,"triangles":9,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010762","count":9},{"id":"GO:0031584","count":9},{"id":"GO:0035564","count":9},{"id":"GO:0051291","count":9},{"id":"GO:0010514","count":9}]},{"hash":"1080754391107908119","title":"Transcriptional Repression and Ubiquitin Regulation","description":"The top GO terms center on negative regulation of transcription by RNA polymerase II, together with ubiquitin-related processes (protein ubiquitination and ERAD) and chromatin/DNA methylation regulation, suggesting these proteins act in gene expression control and protein quality/degradation pathways. Some terms (peroxisome import and developmental processes) are less tightly connected but may reflect broader regulatory roles. Overall, the cluster appears to comprise regulators of transcription and protein homeostasis.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0045886","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0016558","count":2}]},{"hash":"1882923273117538000","title":"Developmental neurovascular remodeling","description":"This cluster\u2019s terms center on vascular development (angiogenesis), neural/synaptic assembly and organization (postsynaptic/presynaptic membrane processes), and embryonic development (in utero development, parturition), with an additional immune-related term (complement activation) that can play a role in developmental remodeling. Taken together, these suggest a theme of coordinated neurovascular development and synaptic formation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":1},{"id":"GO:1902960","count":1},{"id":"GO:0007567","count":1},{"id":"GO:0097104","count":1},{"id":"GO:0001701","count":1}]},{"hash":"1546740577075376531","title":"Amino acid and cofactor biosynthesis","description":"This cluster\u2019s GO terms are dominated by biosynthetic pathways for amino acids and cofactors (beta-alanine, lysine via aminoadipic acid, biotin, tetrahydromethanopterin) and related antibiotic biosynthesis, suggesting a group of enzymes involved in building small molecules, with translation and RNA-regulation terms reflecting basic cellular machinery also present.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019483","count":2},{"id":"GO:0006212","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0006915","count":2}]},{"hash":"292798465054583089","title":"Regulation of cell proliferation and development","description":"This cluster centers on growth, division, and developmental regulation, including root development, apoptosis modulation, negative control of proliferation, cell division, and DNA replication regulation. It also touches on signaling (Wnt pathway inhibition), cell migration, stress responses (stress granule disassembly), and protein quality control (ubiquitin-dependent ERAD). Together these terms suggest a theme of coordinated control of cell fate, growth, and development, with ancillary connections to stress response; the viral process term may reflect host\u2013virus interaction context rather than core function. ","confidence":"Medium","size":12,"edges":42,"triangles":79,"max_degree":9,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0048364","count":5},{"id":"GO:0043065","count":4},{"id":"GO:0016032","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0051301","count":4}]},{"hash":"533541381337963255","title":"Cerebral cortex development and signaling","description":"This cluster centers on brain development, with cortical layer formation, forebrain neuroblast division, and signaling pathways (VEGF and Wnt) that govern neurogenesis and cell migration. Additional terms on actin-based vesicle transport, centrosome maintenance, and peroxisome inheritance reflect cellular organization during neural development, pointing to cortex formation and related signaling processes.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0021873","count":1},{"id":"GO:0051661","count":1},{"id":"GO:0045033","count":1},{"id":"GO:1900748","count":1}]},{"hash":"464581909412889668","title":"Wnt signaling in oogenesis with cytoskeleton dynamics","description":"The top GO terms converge on Wnt signaling, oocyte axis specification, follicle cell stalk formation, and microtubule cytoskeleton organization, all indicative of Drosophila oogenesis and early development, with supporting notes about cytoskeletal remodeling (and some apoptosis/immune-related terms that may reflect broader stress signaling). This combination suggests a cohesive theme around signaling during egg development and cytoskeletal coordination.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0045773","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0042771","count":2}]},{"hash":"1041526474391484692","title":"Regulators of TNF/IL-1/TLR NF-\u03baB signaling","description":"The top GO terms cluster around inflammatory signaling (LPS response, TNF and IL-1 signaling, TLR pathways) with multiple entries for negative regulation of NF-\u03baB and TLR signaling, suggesting these proteins modulate inflammatory responses rather than act as direct effectors. An outlier term related to embryo axis specification is likely noise, but the core theme is clear: regulation of inflammatory signaling networks.","confidence":"High","size":12,"edges":25,"triangles":22,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0034051","count":1},{"id":"GO:0042771","count":1},{"id":"GO:0042347","count":1},{"id":"GO:0033209","count":1}]},{"hash":"1945152142692618533","title":"Neural development and axon signaling","description":"Most top terms center on neuronal development and signaling: paranode axon localization, nerve impulse transmission, Hedgehog signaling, and CAM-mediated cell adhesion; adenosine receptor signaling and STAT phosphorylation also align with neural communication. A single cohesive theme is neural development and axon-based signaling.","confidence":"High","size":12,"edges":14,"triangles":10,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":5},{"id":"GO:0002175","count":5},{"id":"GO:0045663","count":5},{"id":"GO:0034164","count":5},{"id":"GO:0060168","count":5}]},{"hash":"75544579305154403","title":"Axon Guidance and Neural Migration","description":"The terms are dominated by neuronal development, particularly axon guidance and neuron migration (seminal terms like semaphorin-plexin signaling in axon guidance, branchiomotor neuron axon guidance, axonal fasciculation, neuron projection extension, and neural crest migration). A couple of outliers (phagocytosis, motile cilium assembly) appear less central but do not override the clear theme of neuronal pathfinding and migration.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006911","count":2},{"id":"GO:0044458","count":2},{"id":"GO:0021637","count":2},{"id":"GO:0097491","count":2},{"id":"GO:0097490","count":2}]},{"hash":"1565032894148269532","title":"Heart and skeletal development signaling","description":"The top GO terms cluster around skeletal system development, heart development, and multicellular organism development, with related signaling pathways such as PDGFR and PI3K/AKT signaling and VEGF response. This indicates a cohesive developmental signaling module coordinating heart and bone formation with vascular cues, despite the presence of a couple outlier terms like synapse assembly. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0043065","count":4}]},{"hash":"2077684739685839805","title":"Retroviral integration and latency","description":"The GO terms cluster around steps of a retroviral life cycle: RNA-templated DNA biosynthesis (reverse transcription), DNA integration into the host genome, DNA replication/recombination, viral entry into the host nucleus, and establishment of integrated proviral latency, with additional signals of host RNAi suppression. This theme best explains the combined terms, suggesting a retroviral/ proviral context rather than typical host-only processes.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0039651","count":3},{"id":"GO:0006310","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0006278","count":3}]},{"hash":"1761786200087810847","title":"Embryonic organogenesis and morphogenesis","description":"This cluster is enriched for developmental morphogenesis terms across multiple organs (hindlimb, placenta, heart, eye, male gonad, outflow tract) and for transcriptional regulation by RNA Pol II, indicating coordinated embryonic development and organ formation.","confidence":"High","size":12,"edges":61,"triangles":174,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035116","count":4},{"id":"GO:0001890","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0048048","count":4},{"id":"GO:0000122","count":4}]},{"hash":"2207548728830256032","title":"Dopaminergic signaling and vision processing","description":"The cluster is dominated by GO terms tied to neural signaling and plasticity, including dopaminergic synaptic transmission, visual perception, and visual learning, along with ERK/MAPK pathway involvement via protein phosphorylation. This points to a cohesive theme of neural communication with vision-related processing and reward-related signaling. Less central terms like heart development or macrophage chemotaxis appear peripheral to this main neural/vision-focused motif. Confidence: High","confidence":"","size":12,"edges":53,"triangles":116,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":9},{"id":"GO:0008542","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0010759","count":9},{"id":"GO:0048148","count":9}]},{"hash":"1132090707866304247","title":"Axon Guidance and Neuronal Signaling","description":"Top terms cluster around neural growth and signal transduction\u2014positive regulation of axon extension, ephrin receptor signaling, Wnt signaling, and regulation of focal adhesion\u2014alongside neuronal responses to dopamine. Some terms are more general or obsolete, but the strongest theme is axon guidance and neuronal signaling pathways, with cytoskeletal and adhesion components. Confidence is Medium. ","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045773","count":3},{"id":"GO:0000186","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0051301","count":3}]},{"hash":"37996133828996235","title":"Neuronal signaling and migration regulation","description":"Dominant terms point to neural signaling and plasticity: regulation of excitatory postsynaptic potential, cellular response to dopamine, and tangential migration from the subventricular zone to the olfactory bulb; JNK cascade modulation also aligns with signaling control. Other terms such as Th1 immune response and kidney size appear less connected, suggesting a broader set of functions, but the core cluster centers on neuronal signaling and migration.","confidence":"Medium","size":12,"edges":7,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046330","count":5},{"id":"GO:0035564","count":5},{"id":"GO:0035751","count":5},{"id":"GO:0042088","count":5},{"id":"GO:0090394","count":5}]},{"hash":"1976988603008239212","title":"Unknown","description":"The terms are highly heterogeneous: stress-response (immobilization stress, potassium ion response), xenobiotic metabolism and P450 pathways, cell cycle regulation, and reproductive/development terms, with no edges linking proteins into a single coherent function. Without a unifying theme, it's not possible to assign a specific label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035902","count":3},{"id":"GO:0035865","count":2},{"id":"GO:1900087","count":2},{"id":"GO:0033072","count":2},{"id":"GO:0010760","count":2}]},{"hash":"1939262305439285951","title":"Ubiquitin-regulated genome maintenance","description":"The top GO terms show strong representation of ubiquitination (protein ubiquitination, polyubiquitination) alongside DNA replication and recombination, and telomere capping regulation. This pattern points to a theme of ubiquitin-mediated control of genome maintenance processes, with additional signals related to cellular signaling (TGF-beta) and vitamin D responses that can intersect with ubiquitin pathways. The mix suggests a broader but coherent role in ubiquitin-dependent regulation of genome stability and related signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000209","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0043066","count":3}]},{"hash":"878435154566192215","title":"Bacterial stress-responsive metabolism and quinone biosynthesis","description":"The cluster blends stress-related GO terms (response to hypoxia, UV protection, nucleotide-excision repair) with diverse biosynthetic and catabolic processes, especially quinone biosynthesis (menaquinone, phylloquinone) and fatty acid metabolism, suggesting a broad bacterial metabolic module tied to energy/redox balance and stress adaptation rather than a single specific pathway.","confidence":"Medium","size":12,"edges":12,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0009650","count":2}]},{"hash":"415389928370554035","title":"Unknown","description":"The top GO terms span angiogenesis, development, immune antigen presentation, neural plasticity, reproduction, and kidney podocyte development, with no clear shared function across the proteins. Because the set lacks a single cohesive biological theme, there isn't a concise, representative label beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0019885","count":3},{"id":"GO:0008542","count":2}]},{"hash":"1399447345787454936","title":"Stress and Defense Response with Host Interaction","description":"The top GO terms point to stress response, detoxification, and defense-related processes (dormancy in host-associated symbionts, antibiotic biosynthesis, detoxification). While there are also signaling-related terms (immune activation, endothelial migration, insulin regulation, behavior), the dominant themes are stress defense and host-microbe interaction, making this a cohesive high-level label. ","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":4},{"id":"GO:0006950","count":4},{"id":"GO:0098869","count":3},{"id":"GO:0015996","count":3},{"id":"GO:0017000","count":2}]},{"hash":"1119664504710123795","title":"Neuronal signaling and circadian regulation","description":"The cluster is characterized by neuronal-related terms (locomotory behavior, startle response, long-term potentiation) and circadian sleep regulation, along with ion transport (potassium and calcium). This points to a neuronal signaling/circadian function; a few outliers (blood coagulation, GTPase regulation) likely reflect multifunctional proteins rather than the core theme.","confidence":"Medium","size":12,"edges":6,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007626","count":6},{"id":"GO:1900273","count":5},{"id":"GO:0045188","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0098703","count":5}]},{"hash":"1972033713519150090","title":"Coagulation, complement activation, and angiogenesis","description":"The GO terms point to coagulation and fibrinolysis (complement activation, plasminogen activation, fibrinolysis), plus platelet activation, endothelial migration, and angiogenesis, all within an immune-vascular context. ERK signaling and adaptive immune response add a layer of signal transduction and immune involvement, suggesting a thromboinflammatory program that links coagulation, complement activity, and blood vessel remodeling. ","confidence":"High","size":12,"edges":8,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0042730","count":7},{"id":"GO:1902042","count":6},{"id":"GO:0031639","count":6},{"id":"GO:0002250","count":5}]},{"hash":"1509132597326617534","title":"Glycosylation and carbohydrate biosynthesis","description":"The cluster is driven by GO terms tied to glycan assembly and carbohydrate metabolism (protein N-linked glycosylation, poly-N-acetyllactosamine biosynthetic process, mucilage biosynthesis, general carbohydrate metabolic process), with several development- and signaling-related terms likely reflecting broader roles of glycosylation in development and intercellular interactions. The strongest unifying theme is glycosylation and carbohydrate biosynthesis pathways.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006487","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0042248","count":1},{"id":"GO:0030311","count":1},{"id":"GO:0036011","count":1}]},{"hash":"1956863225816969570","title":"Neural development and axon guidance","description":"The cluster shows a cohesive signal around neural development and neurite pathfinding, including anterior/posterior axon guidance, fasciculation of sensory neuron axons, neuron remodeling, and astrocyte development. Additionally, extracellular matrix disassembly and substrate adhesion-dependent spreading point to coordinated tissue morphogenesis and cell migration accompanying neural development. ","confidence":"Medium","size":12,"edges":51,"triangles":111,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0033564","count":3},{"id":"GO:0043652","count":3},{"id":"GO:0014002","count":2},{"id":"GO:0097155","count":2},{"id":"GO:0016322","count":2}]},{"hash":"1905807932042400953","title":"Stress-Responsive Translational Regulation","description":"This cluster's top terms include translation (GO:0006412) and negative regulation of translation, plus a stress response term (response to immobilization stress), indicating a theme of translational control under stress.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0035902","count":2},{"id":"GO:0046373","count":1},{"id":"GO:0045493","count":1},{"id":"GO:0006683","count":1}]},{"hash":"1769516048700040920","title":"Diverse solute transporters","description":"The top GO terms reveal multiple transmembrane transport activities across a range of substrates (xenobiotics, nitrite, potassium, phosphate, sialic acid, arabinose, hydroxyphenylacetate, vitamin transport, etc.), with no single substrate common to all. This suggests a cluster of membrane transporter proteins with diverse substrate specificities rather than a single, substrate-specific transporter family. Therefore, a concise label like \u201cDiverse solute transporters\u201d captures the shared function. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0035435","count":3},{"id":"GO:0015739","count":3}]},{"hash":"850980177669292769","title":"Melanin biosynthesis and pigmentation","description":"This cluster is dominated by GO terms for melanin biosynthesis, melanosome organization, and pigmentation, including melanin production from tyrosine, pointing to pigment cell biology (melanocytes) and related pathways. The brain development terms (neuroblast proliferation, ventricular zone division) and face morphogenesis can be connected to neural crest\u2013derived pigment cells, providing a developmental context for pigmentation. A few terms (like cellulose catabolism and an obsolete oxidation-reduction term) appear as noise, but they do not outweigh the pigment-related theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048023","count":2},{"id":"GO:0021847","count":2},{"id":"GO:0032438","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006583","count":2}]},{"hash":"1445642356712945775","title":"Coronary vascular morphogenesis","description":"This cluster is dominated by GO terms tied to coronary angiogenesis, VEGF signaling in endothelial cells, and coronary artery morphogenesis, with accompanying endothelial migration and heart-development terms, indicating a cohesive role in coronary vessel formation. A couple of terms (mitotic spindle attachment and axon guidance) appear less related and may reflect broader cellular processes, but the vascular/heart morphogenesis theme is strong. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060978","count":3},{"id":"GO:0048010","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0048842","count":3},{"id":"GO:0035265","count":2}]},{"hash":"707867122245012990","title":"Angiogenesis and Endothelial Morphogenesis","description":"The cluster is strongly enriched for GO terms related to angiogenesis, vascular endothelial growth factor signaling, endothelial cell migration and proliferation, venous vessel morphogenesis, and organ morphogenesis, suggesting a shared role in blood vessel formation and vascular development. A single RNA splicing term appears incidental and does not override the dominant vascular theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008380","count":1},{"id":"GO:0045766","count":1},{"id":"GO:0001525","count":1},{"id":"GO:0048845","count":1},{"id":"GO:0030947","count":1}]},{"hash":"2239571616433778864","title":"Rho-driven cytoskeleton and polarity","description":"The top GO term is regulation of Rho protein signal transduction (5), which ties to actin cytoskeleton dynamics and junction/polarity processes (paranodal junction assembly, epithelial polarity). While the cluster includes diverse terms (paranode localization, thyroid response, lens differentiation, glucose absorption), the common thread appears to be Rho-mediated control of cytoskeleton and cell polarity. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0048549","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0002175","count":2},{"id":"GO:0097067","count":2}]},{"hash":"1420755424265233795","title":"Microtubule-Driven Transport and Cytoskeleton Regulation","description":"This cluster centers on regulation of the cytoskeleton and microtubule-based movement, including intracellular transport (even viral cargo) along microtubules, plus regulators like GTPases. Developmental terms such as neuron projection morphogenesis and spermatid development suggest cytoskeletal remodeling during development, reinforcing the core theme of cytoskeleton dynamics and intracellular transport.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051493","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0007018","count":1},{"id":"GO:0019060","count":1},{"id":"GO:0075521","count":1}]},{"hash":"215659290321947188","title":"Innate antiviral immune signaling","description":"This cluster is dominated by innate immune and antiviral terms: innate immune response, defense response to virus, dsRNA response, and NOD-like receptor signaling, indicating a cohesive antiviral innate signaling role. Some terms like mitochondrial fission, calcium release, and ubiquitin-dependent degradation may reflect downstream signaling or cellular stress linked to immune activation, while a couple of development terms appear as less central annotations.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0051607","count":4},{"id":"GO:0008284","count":3},{"id":"GO:0090141","count":3},{"id":"GO:0007275","count":3}]},{"hash":"2175403148820486493","title":"Membrane trafficking and developmental processes","description":"Top terms center on membrane dynamics (phospholipid homeostasis; plasma membrane\u2013endosome transport) and development (spermatid, nervous system development; kidney size regulation). The overlap of membrane trafficking-related terms with broad developmental programs points to a cluster of proteins involved in membrane dynamics coordinating developmental processes, rather than a single pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0048227","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1153873713400120857","title":"Neuronal development and synapse organization","description":"The cluster is enriched for GO terms related to nervous system development, synapse organization, and dendrite development, indicating a cohort of proteins involved in neural differentiation and formation of synaptic connections. A few minor terms about immune signaling and protein regulation appear but do not dominate the theme; overall the shared function points to neural development and synaptic maturation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0061060","count":1},{"id":"GO:1903094","count":1}]},{"hash":"4694712965834377","title":"Actin Cytoskeleton Remodeling and Golgi-Exocytosis","description":"The terms center on actin cytoskeleton organization/remodeling, Rho signaling regulation, Golgi localization, exocytosis, and cell polarity, indicating a coordinated role in cytoskeletal dynamics and vesicle trafficking at the Golgi.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0051683","count":4},{"id":"GO:0030036","count":4},{"id":"GO:2000009","count":3},{"id":"GO:0006887","count":3}]},{"hash":"446925165672581273","title":"Developmental Signaling and Cell Fate","description":"The top GO terms point to broad developmental roles (heart development, compound eye development) and pathways that govern cell fate (hippo signaling, cell fate commitment). The presence of apoptosis-related terms fits developmental remodeling, while glucocorticoid and TNF responses suggest stress-modulated development and immune or tissue homeostasis. Taken together, the cluster seems to reflect developmental signaling and differentiation processes across tissues, with ancillary roles in apoptosis and stress responses rather than a single cohesive function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0035329","count":1},{"id":"GO:0007611","count":1},{"id":"GO:0045165","count":1},{"id":"GO:0008635","count":1}]},{"hash":"1802073893706977462","title":"Neurodevelopment and metabolism","description":"The top GO terms cluster around embryonic and neural development (in utero embryonic development, pituitary gland development, neuron maturation) with supporting neural signaling (cellular response to cAMP, dopamine catabolic process). Metabolic and redox-related terms (beta-alanine biosynthesis, lipoate metabolic process, redox homeostasis) suggest a coordinated developmental program with metabolic regulation. An additional transcriptional regulation/epigenetic hint (regulation of DNA-templated transcription, histone demethylation) aligns with developmental gene control. Overall, these proteins appear linked to neural development and associated metabolic processes.","confidence":"Medium","size":11,"edges":13,"triangles":12,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":6},{"id":"GO:0006355","count":6},{"id":"GO:0021983","count":6},{"id":"GO:0042551","count":5},{"id":"GO:0071320","count":5}]},{"hash":"763591463536687609","title":"Developmental transcription regulators","description":"The cluster shows strong signals for transcriptional regulation by RNA polymerase II (both positive and negative), pointing to transcriptional control. Coupled with several developmental and neural patterning terms (rhombomere 5 development, brain segmentation, segment specification, pronephric glomerulus development, collateral sprouting of injured axon), the theme appears to be transcriptional regulation involved in developmental and neural patterning. Some outlier terms (blood coagulation, oxidative stress response, respiration) are present but don\u2019t override the primary signal. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0030194","count":3},{"id":"GO:0021571","count":3},{"id":"GO:0070301","count":3},{"id":"GO:0045944","count":3}]},{"hash":"40850237625082866","title":"Unknown","description":"The terms span immune/stress responses, neural development and sensory functions, and hematopoietic processes with no clear shared pathway or strong connectivity, so there is no cohesive theme to assign a specific label.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0035094","count":2},{"id":"GO:0043200","count":2},{"id":"GO:1904645","count":2}]},{"hash":"474006221765903472","title":"Neural development and cholinergic signaling","description":"The top GO terms point to neural development processes such as axon guidance, retina and Schwann cell development, radial glia\u2013mediated migration, and neuronal\u2013glial interactions, along with cholinergic signaling pathways (G protein-coupled acetylcholine receptor signaling and cholinergic synaptic transmission). This suggests the proteins in the cluster collectively participate in neural development and related cholinergic signaling, with some additional roles in general morphogenesis. Overall, a cohesive theme is neural development with emphasis on cholinergic signaling.","confidence":"Medium","size":11,"edges":38,"triangles":63,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1905815","count":4},{"id":"GO:0072249","count":4},{"id":"GO:0043113","count":4},{"id":"GO:0032224","count":4},{"id":"GO:0014044","count":4}]},{"hash":"1216720469279841089","title":"RNA Processing and Ribosome Biogenesis","description":"The cluster is enriched for spliceosome- and rRNA-related processes (mRNA splicing, SSU maturation, preribosome and large subunit biogenesis), plus P-body assembly and RNA regulation, indicating a cohesive RNA processing and ribosome biogenesis program.","confidence":"High","size":11,"edges":40,"triangles":66,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006369","count":4},{"id":"GO:0045292","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0042273","count":3}]},{"hash":"1045684722634113641","title":"Dopaminergic signaling and sensory processing","description":"The terms cluster around neural signaling and response to stimuli: dopaminergic synaptic transmission, visual perception and learning, pain perception, and behavioral responses to drugs (morphine, cocaine). ERK1/2 pathway regulation and prostaglandin-related responses further support neuromodulatory signaling. While a couple terms (heart development, macrophage chemotaxis) are less directly linked, the dominant theme is nervous system signaling and sensory/drug responses.","confidence":"Medium","size":11,"edges":21,"triangles":9,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":9},{"id":"GO:0008542","count":9},{"id":"GO:0043278","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0010759","count":9}]},{"hash":"1879321288981312759","title":"Innate Immune Activation and Leukocyte Trafficking","description":"The top GO terms cluster around innate immune responses and leukocyte interactions\u2014cellular response to fungal origin, phagocytosis recognition, basophil activation, leukocyte tethering/rolling, platelet activation, and arachidonate secretion\u2014suggesting a representative theme of immune activation and inflammatory signaling. A few development-related terms appear but do not dominate the set, so an immune-focused label is most appropriate.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001502","count":9},{"id":"GO:0071226","count":9},{"id":"GO:0006910","count":8},{"id":"GO:0010572","count":8},{"id":"GO:0045575","count":8}]},{"hash":"373720919909778649","title":"Dorsal-Ventral Axis Patterning","description":"This cluster's GO terms strongly point to embryonic axis formation and polarity\u2014specifically polarization and maternal specification of the dorsal/ventral axis, plus midbrain-hindbrain boundary development\u2014suggesting a core theme of developmental patterning. Additional terms (cholesterol transport, integrin activation, phagolysosome assembly) appear ancillary rather than central to this theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002642","count":2},{"id":"GO:0030917","count":2},{"id":"GO:0032367","count":2},{"id":"GO:0007311","count":2},{"id":"GO:2001274","count":2}]},{"hash":"1744897584551255236","title":"Mitochondrial Transporters and Metabolic Shuttles","description":"The top GO terms cluster around transport across the mitochondrial membrane and associated metabolic shuttles (ADP, NAD, citrate, malate-aspartate shuttle, pyrimidine nucleotide import, ornithine transport), indicating these proteins function as mitochondrial carriers involved in metabolite exchange and energy metabolism; insulin-related terms likely reflect regulatory signaling context rather than a different function.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090149","count":5},{"id":"GO:0000002","count":5},{"id":"GO:1990519","count":4},{"id":"GO:0000066","count":4},{"id":"GO:0043490","count":4}]},{"hash":"2151845859400129085","title":"Rho-Integrin Signaling and Stress Response","description":"This cluster shows enrichment in cytoskeletal/adhesion signaling (Rho regulation and integrin signaling) together with regulatory processes like protein ubiquitination and calcineurin-NFAT signaling. It also includes stress-related terms (response to fungal origin, autophagy, ER stress regulation) and growth-related processes (DNA replication, organ growth), suggesting a set of proteins involved in signaling networks that coordinate growth and cellular stress responses rather than a single pathway. ","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0051531","count":3},{"id":"GO:0071226","count":3}]},{"hash":"1886800636341934489","title":"Hypoxia-driven stress signaling and RNA regulation","description":"These proteins show a strong tilt toward cellular stress responses under low-oxygen conditions: hypoxia response, EMT, astrocyte activation, and ROS generation. The concurrent presence of calcium signaling cues and regulation of RNA processing and mRNA transport suggests an integrated program of signal transduction and post-transcriptional control in stressed cells, potentially in neural/glial contexts. Overall, a cohesive theme of hypoxia-associated stress signaling with RNA regulation.","confidence":"Medium","size":11,"edges":48,"triangles":114,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001837","count":10},{"id":"GO:0090281","count":10},{"id":"GO:0071456","count":10},{"id":"GO:0042554","count":10},{"id":"GO:0051028","count":10}]},{"hash":"2119090169508814441","title":"Oxidative stress response and inflammatory signaling","description":"The cluster centers on GO terms related to detoxification of oxidants and redox homeostasis, with links to inflammatory signaling pathways (MAPK cascade regulation and I-kappaB phosphorylation) and prostaglandin biosynthesis. While there are some accompanying metabolic terms, the dominant theme is redox management coupled with inflammatory signal transduction.","confidence":"Medium","size":11,"edges":42,"triangles":92,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0045454","count":4},{"id":"GO:0055114","count":4},{"id":"GO:2000255","count":4},{"id":"GO:0001516","count":4}]},{"hash":"1053768189533544837","title":"Gene Expression and Protein Assembly","description":"This cluster is dominated by GO terms for translation and DNA-templated transcription, and by multiple terms about protein oligomerization (heterooligomerization and homotetramerization). Together they point to core gene-expression processes and the assembly/organization of protein complexes, despite a few metabolic or stress-related terms that are less representative. ","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006351","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0006120","count":1},{"id":"GO:0006729","count":1}]},{"hash":"103206424036821537","title":"Craniofacial bone development and ECM adhesion","description":"This cluster centers on skeletal and craniofacial morphogenesis, with terms like skeletal system development, roof of mouth development, and bone trabecula formation, plus BMP signaling regulation. The simultaneous enrichment for cell-matrix and cell-substrate adhesion highlights extracellular matrix interactions that drive tissue shaping during bone/craniofacial formation. A few reproductive-related terms appear but are not the primary theme; the dominant signal is craniofacial bone development and ECM adhesion.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0010811","count":3},{"id":"GO:0060021","count":2},{"id":"GO:0097211","count":2}]},{"hash":"536041730356143905","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902187","count":3},{"id":"GO:0007014","count":3},{"id":"GO:2000637","count":3},{"id":"GO:0061158","count":3},{"id":"GO:0070431","count":2}]},{"hash":"2006563238245899947","title":"Vascular Adhesion and ECM Remodeling","description":"The cluster is dominated by GO terms related to vascular and extracellular matrix interactions, including blood coagulation, integrin-mediated signaling, cellular extravasation, heterotypic cell\u2013cell adhesion, and hyaluronan metabolism. These collectively point to processes governing cell adhesion, ECM engagement, and movement through blood vessels. Some terms appear as outliers (plant-specific chlorophyll biosynthesis, stamen formation), likely noise or cross-species annotations, but the core signal centers on ECM interaction and vascular adhesion.","confidence":"Medium","size":11,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0006511","count":4},{"id":"GO:0007229","count":4},{"id":"GO:0006471","count":3},{"id":"GO:0030212","count":3}]},{"hash":"1561486084126686799","title":"Lipid metabolism and vitamin biosynthesis","description":"Dominated by fatty acid beta-oxidation and ketone body biosynthesis terms, with key vitamin biosynthesis (menaquinone, phylloquinone) and related catabolic processes; these point to a unifying theme of lipid-energy metabolism and vitamin biosynthesis. Some outliers (antibiotic biosynthesis, liver/adipose development) are present but don't redefine the core theme.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006635","count":9},{"id":"GO:0017000","count":7},{"id":"GO:0009234","count":6},{"id":"GO:0010124","count":6},{"id":"GO:0042372","count":6}]},{"hash":"591254414411429410","title":"Vascular morphogenesis and EMT signaling","description":"The cluster centers on developmental processes: branching morphogenesis of blood vessels, epithelial-to-mesenchymal transition, and Wnt-related signaling, with supporting developmental terms such as collecting duct development. Some terms are obsolete or may reflect broader cytoskeletal processes, but the dominant themes point to morphogenesis and EMT signaling in development.","confidence":"Medium","size":11,"edges":23,"triangles":10,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001569","count":3},{"id":"GO:0001837","count":2},{"id":"GO:0007223","count":2},{"id":"GO:1901841","count":2},{"id":"GO:0002086","count":2}]},{"hash":"2279064258583176579","title":"RNA processing and translation initiation machinery","description":"The cluster centers on RNA metabolism and gene expression control: regulatory ncRNA-mediated silencing, spliceosome-regulated mRNA splicing, small-subunit processome assembly, mRNA export, and assembly of translation initiation complexes (eIF4F) and IRES-driven initiation. While a few terms are obsolete or development-related, the core themes tie to RNA maturation, export, and initiation of translation, pointing to a coordinated RNA-processing/translation machinery function.","confidence":"Medium","size":11,"edges":48,"triangles":112,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":10},{"id":"GO:0048026","count":10},{"id":"GO:0034462","count":6},{"id":"GO:0006378","count":6},{"id":"GO:0097010","count":6}]},{"hash":"1102220044517340081","title":"Immune and neural development signaling cluster","description":"The top GO terms point to immune processes (mast cell chemotaxis, TH1 response, IL-23 regulation) and neural development signals (Roundabout signaling, nervous system development, spermatid development), with ERK cascade and PI3K activity as central signaling pathways. The presence of ossification hints at bone development, but the common thread appears to be signaling networks that coordinate immune and neural/developmental processes. Thus a label emphasizing immune and neural development signaling best captures the cluster's core theme, despite some peripheral terms.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002551","count":10},{"id":"GO:0035385","count":10},{"id":"GO:0043931","count":10},{"id":"GO:0071260","count":10},{"id":"GO:0070374","count":10}]},{"hash":"2200548935960826122","title":"Ribosome biogenesis and translation","description":"Dominant terms center on translation and ribosome biogenesis, including export of the ribosomal large subunit from the nucleus and regulation of translational elongation, with additional signals related to mRNA turnover and cell cycle\u2013related proliferation. This suggests a cohesive theme of ribosome assembly and protein synthesis machinery driving cellular growth. ","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0001514","count":2}]},{"hash":"807736248950239117","title":"TLR4-mediated inflammatory response to Gram-positive bacteria","description":"The top GO terms converge on innate immune signaling via TLR4, recognizing Gram-positive bacterial components like lipoteichoic acid, triggering inflammatory cytokine and chemokine production (IL-8, IL-1\u03b2, chemokines), and overall inflammatory defense.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046330","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0034142","count":4}]},{"hash":"512003305107537918","title":"Hypoxia-Responsive Signaling and Cell Proliferation","description":"Top GO terms point to hypoxia response, mitotic cell cycle, and regulation of kinase activity and phosphorylation, suggesting proteins in this cluster participate in hypoxia-triggered signaling that modulates cell proliferation and protein modification. Some terms like mRNA transport and smooth muscle development are less central but may reflect broader regulatory roles. Overall, the cluster appears to be a hypoxia-associated signaling module linked to cell cycle regulation and post-translational changes.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0071902","count":2}]},{"hash":"828273491627284731","title":"Neurodevelopmental signaling and brain formation","description":"The cluster is enriched for nervous system development, brain development, and neurogenesis, with Hedgehog (Smoothened) and Slit-Robo signaling highlighted, pointing to neural patterning and axon guidance. While a few terms relate to kidney development or ossification, the dominant theme is neural development and associated signaling pathways, making this a cohesive neurodevelopment cluster.","confidence":"High","size":11,"edges":35,"triangles":44,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0022008","count":3}]},{"hash":"1283229790073633951","title":"Negative regulation of signaling pathways","description":"The top GO terms cluster around inhibition of signaling across multiple systems: VEGF receptor signaling, T cell receptor signaling, ERK/MAPK cascades, IL-2 signaling, PDGFR signaling, and integrin-mediated adhesion, indicating a general role as broad negative regulators of signaling networks. An outlier term about vestibular morphogenesis is likely incidental noise. ","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":10},{"id":"GO:0050860","count":10},{"id":"GO:0070373","count":10},{"id":"GO:0000200","count":10},{"id":"GO:1902206","count":9}]},{"hash":"359450272147319592","title":"Chemical and xenobiotic stress response","description":"The cluster shows proteins linked to responses to a variety of chemical stresses and xenobiotics (lipopolysaccharide, camphor, aluminum ion, herbicide, xenobiotic stimulus, ethanol) and redox homeostasis, suggesting a common role in detoxification and environmental response. A development-related term is present but not dominant, so the core theme appears to be chemical stress response and related inflammation regulation.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0002677","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0019383","count":2}]},{"hash":"1303092714954078828","title":"Dopamine and Adrenergic GPCR Signaling","description":"The cluster is enriched for GO terms tied to GPCR-mediated signaling, especially dopamine receptor signaling and adenylate cyclase-activating adrenergic receptor signaling, along with downstream cAMP and PLC pathways. Related terms like thermogenesis and heart development can be downstream effects of sympathetic GPCR activity, supporting a cohesive dopamine/adrenergic signaling module.","confidence":"High","size":11,"edges":8,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008283","count":4},{"id":"GO:0007603","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0010513","count":4},{"id":"GO:0043950","count":4}]},{"hash":"1139800486178136898","title":"Glutamatergic synapse regulation","description":"Top GO terms point to modulation of glutamatergic transmission, NMDA receptor clustering, and synapse assembly, suggesting proteins involved in shaping glutamatergic synapses. Adhesion and integrin signaling terms may reflect synaptic adhesion processes that support synapse formation and maintenance, reinforcing the neuronal synapse theme. Overall, the cluster seems centered on glutamatergic synapse function.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":5},{"id":"GO:0010641","count":4},{"id":"GO:0070527","count":4},{"id":"GO:2000821","count":4},{"id":"GO:0007416","count":4}]},{"hash":"59527483681958973","title":"Lipid mediator biosynthesis and xenobiotic metabolism","description":"The strongest signals are prostaglandin biosynthesis and epoxygenase P450 pathways, pointing to lipid mediator production. Reproductive roles (sex differentiation and maternal parturition) align with prostaglandin signaling, while xenobiotic catabolic processes and organofluorine metabolism suggest detoxification-related functions that commonly accompany lipid signaling networks. Together, these terms define a theme around lipid mediator synthesis coupled with xenobiotic metabolism, justifying this label.","confidence":"Medium","size":11,"edges":22,"triangles":17,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":10},{"id":"GO:0035865","count":8},{"id":"GO:1900087","count":8},{"id":"GO:0033072","count":8},{"id":"GO:0010760","count":8}]},{"hash":"658061090428209136","title":"Cortical development and GPCR signaling","description":"The cluster centers on cortical layer formation and synapse assembly, with GPCR-mediated signaling (adenylate cyclase and PLC pathways) as a core mechanism. The presence of angiogenesis-related terms suggests neurovascular development in the cortex, while the electron transport chain term reflects neuronal metabolic activity. Altogether, these terms point to cerebral cortex maturation involving GPCR-driven signaling and associated vascular remodeling.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0007189","count":6},{"id":"GO:1900747","count":6},{"id":"GO:0016525","count":6},{"id":"GO:0007200","count":6}]},{"hash":"334318830254210383","title":"Ciliary motility and intraflagellar transport","description":"This cluster's terms cluster around cilia/flagella functions: cilium movement, intraciliary transport, and inner dynein arm assembly, with related processes like left-right symmetry determination and spindle localization, all pointing to a shared role in ciliary motility and intraflagellar transport, with some overlap into microtubule-based mitotic processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034063","count":1},{"id":"GO:0007368","count":1},{"id":"GO:0072382","count":1},{"id":"GO:0035721","count":1},{"id":"GO:1990048","count":1}]},{"hash":"608395342768964770","title":"Innate immune response to Gram-positive bacteria","description":"The top GO terms are dominated by innate immune response and defense against Gram-positive bacteria, indicating the cluster\u2019s primary function is immune defense. Some mitosis-related terms appear among less frequent annotations, which may reflect annotation overlap or multifunctional proteins, but the prevailing signal supports an immune-focused cluster.","confidence":"High","size":11,"edges":36,"triangles":44,"max_degree":10,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0050830","count":9},{"id":"GO:0046827","count":7},{"id":"GO:0051316","count":6},{"id":"GO:0000189","count":6}]},{"hash":"1496331352986176326","title":"Microtubule dynamics and cytoskeletal organization","description":"The top terms highlight microtubule-directed processes (plus- and minus-end sliding, axonemal depolymerization, mitotic chromosome alignment) and general cytoskeletal/orientational roles, suggesting a cluster centered on microtubule dynamics and cytoskeletal architecture. Some terms reflect broader developmental or adhesion contexts, but they can be linked to the overarching theme of cytoskeletal regulation. ","confidence":"High","size":11,"edges":22,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0021693","count":4},{"id":"GO:0009904","count":3},{"id":"GO:0031534","count":3},{"id":"GO:0048364","count":3},{"id":"GO:0000743","count":3}]},{"hash":"929647299554723838","title":"DNA replication, repair, and mitosis machinery","description":"This cluster shows strong representation of DNA-templated transcription, DNA replication, and DNA repair alongside mitotic cell cycle processes such as centrosome separation, spindle organization, and kinetochore-microtubule attachment. Together these terms point to proteins involved in genome maintenance and chromosome segregation during cell division. Some obsolete terms appear, but the core signal aligns with DNA maintenance and mitotic machinery. ","confidence":"High","size":11,"edges":22,"triangles":15,"max_degree":10,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0006281","count":11},{"id":"GO:0006260","count":11},{"id":"GO:0000278","count":11},{"id":"GO:0051316","count":9}]},{"hash":"1174033654146367280","title":"Embryonic Development and Tissue Differentiation","description":"The cluster\u2019s GO terms cluster around developmental and differentiation processes across multiple tissues (cartilage, placenta, pancreas, endocrine system) and body plan organization (left-right patterning), indicating a group of proteins involved in embryonic development and organ differentiation rather than a single pathway.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000083","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0043066","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0060536","count":2}]},{"hash":"2201479382055972073","title":"Cell cycle and ribosome biogenesis","description":"The cluster is enriched for cell division and mitotic cell cycle terms, along with ribosome biogenesis and nucleolar ribosomal subunit export, pointing to a coordinated program of cell proliferation and protein synthesis. Developmental terms like smoothened signaling and brain development appear, but the dominant signal centers on cell cycle progression and ribosome assembly.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0000278","count":7},{"id":"GO:0007224","count":6},{"id":"GO:0000747","count":5},{"id":"GO:0042254","count":5}]},{"hash":"1127304745485246059","title":"Amino Acid Biosynthesis and Central Carbon Metabolism","description":"The cluster is dominated by biosynthetic processes for several amino acids (serine, tyrosine) and central carbon metabolism (pyruvate, glyoxylate), with additional terms touching on cell wall organization and regulatory/cofactor-related processes (response to cAMP, response to vitamin B6, Fe-S cluster assembly). This combination points to a cohesive metabolic focus on amino acid production and central metabolism, complemented by cell envelope and regulatory/cofactor maintenance activities.","confidence":"Medium","size":11,"edges":50,"triangles":126,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042866","count":5},{"id":"GO:0006564","count":5},{"id":"GO:0051591","count":4},{"id":"GO:0019878","count":4},{"id":"GO:0071555","count":4}]},{"hash":"920587583580748333","title":"DNA Repair and Meiotic Recombination","description":"The top GO terms cluster around DNA-related processes: DNA-templated transcription, DNA recombination, synaptonemal complex assembly, translesion synthesis, and mitotic spindle assembly checkpoint, which together point to genome maintenance during replication and meiosis. Other terms like xenobiotic response, virus defense, and metabolism may reflect broader cellular roles or annotation noise, but the dominant signal supports a DNA repair/recombination theme.","confidence":"Medium","size":11,"edges":14,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0002098","count":2},{"id":"GO:0090267","count":2}]},{"hash":"15525233370091428","title":"Vitamin B6 biosynthesis and amino acid metabolism","description":"This cluster shows enrichment for pyridoxine biosynthetic process and multiple amino acid metabolism terms (L-serine biosynthesis, L-alanine catabolism, L-valine catabolism, L-kynurenine catabolic), suggesting a link to vitamin B6-related metabolism and amino acid turnover. Some other terms (DNA repair, cAMP response, Fe-S cluster iron incorporation) may reflect generalized cellular functions or cofactors, but the dominant signals point to B6 and amino acid metabolism.","confidence":"Medium","size":11,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008615","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0042853","count":2},{"id":"GO:0006564","count":2},{"id":"GO:0006574","count":2}]},{"hash":"1419439046536556421","title":"Regulation of signaling, transcription, and cell cycle","description":"This cluster centers on regulatory processes that coordinate signaling (including NF-kappaB) with gene expression (transcription, translation, mRNA transport) and cell cycle events (mitosis, cytokinesis), plus regulatory layers like ubiquitination and nuclear import. The common theme is modulation of multiple core cellular processes rather than a single pathway or function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0051028","count":2}]},{"hash":"99624837766724799","title":"Immune cell activation and leukocyte trafficking","description":"The top GO terms cluster around immune responses, including phagocytosis recognition, leukocyte tethering/rolling, basophil activation, NK cell chemotaxis regulation, cellular response to fungal origin, and inflammatory mediator (arachidonate) secretion, as well as platelet activation, suggesting a cohesive theme of immune activation and leukocyte recruitment; a few developmental terms appear as related signaling contexts but do not contradict this core theme.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":10},{"id":"GO:0006910","count":10},{"id":"GO:0010572","count":10},{"id":"GO:0045575","count":10},{"id":"GO:0050901","count":10}]},{"hash":"517619792249077905","title":"Adipocyte lipid signaling and differentiation","description":"The cluster shows enrichment in fat cell differentiation and glycerophospholipid catabolic processes, with hints of PI3K signaling involvement, which together point to adipocyte lipid metabolism and differentiation as a core theme. Calcium release and pinocytosis may reflect general cellular uptake and signaling processes in adipose tissue, while a couple of terms appear less related, but do not undermine the central adipose/metabolic signal. ","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":2},{"id":"GO:0060665","count":2},{"id":"GO:0051209","count":1},{"id":"GO:0046475","count":1},{"id":"GO:0035508","count":1}]},{"hash":"2222382969658436191","title":"Glycan biosynthesis and cell wall assembly","description":"The cluster is dominated by GO terms for cell wall organization and teichoic acid/glycan biosynthesis (e.g., formation of infection structure, teichoic acid biosynthetic process, O-linked glycosylation, keratan sulfate proteoglycan biosynthesis). This points to a common theme of glycan construction and cell envelope assembly, with teichoic acid and related glycosylation pathways as a core signal, though a few terms about mammalian development appear as potential noise. Overall, the label reflects the main functionalSignals in the cluster.","confidence":"Medium","size":11,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0071555","count":4},{"id":"GO:0016266","count":4},{"id":"GO:0018146","count":3},{"id":"GO:0036108","count":3}]},{"hash":"994599134818954009","title":"Zinc Ion Transport and Homeostasis","description":"The cluster shows strong representation of zinc-related processes: zinc ion import across the plasma membrane, intracellular zinc ion homeostasis, detoxification of zinc, and response to zinc ion starvation, which together point to a coherent theme of zinc handling. Some coagulation and cell adhesion terms appear but are less central to the dominant zinc transport/homeostasis theme.","confidence":"High","size":11,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0034224","count":1},{"id":"GO:0010312","count":1},{"id":"GO:0006830","count":1}]},{"hash":"730623893211978646","title":"Neural development and synaptic signaling","description":"This cluster centers on neuron development, synapse formation and glutamatergic transmission, with accompanying signaling pathways (PDGF and insulin receptor signaling) and adhesion/cell-spreading cues (integrin signaling, substrate adhesion). These collectively point to proteins involved in neural growth, connectivity, and synaptic communication, despite occasional inclusion of other pathway terms.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010641","count":5},{"id":"GO:0051968","count":5},{"id":"GO:0034446","count":4},{"id":"GO:0007229","count":4},{"id":"GO:0050852","count":4}]},{"hash":"570739418177836815","title":"Steroid hormone biosynthesis and fatty acid biosynthesis","description":"The cluster centers on multiple GO terms for steroid biosynthesis (estrogen, testosterone, glucocorticoid, C21-steroid metabolism) and includes a related fatty acid biosynthetic term, suggesting a cohesive role in steroidogenesis and lipid biosynthesis pathways. Some outliers (sporulation, redox) are less central to the core theme.","confidence":"High","size":11,"edges":12,"triangles":1,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008207","count":6},{"id":"GO:0006703","count":6},{"id":"GO:0042761","count":6},{"id":"GO:0006710","count":6},{"id":"GO:0061370","count":6}]},{"hash":"601995759077211474","title":"Diverse tissue development","description":"The top GO terms cluster around developmental processes across multiple tissues (thymus, placenta, heart, Schwann cells, visual perception). While a few terms point to signaling or stress responses (MAPK, ABA signaling, cadmium response), the strongest signal is multi-tissue development, suggesting these proteins are associated with broad developmental programs rather than a single pathway. ","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0048538","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0007507","count":3}]},{"hash":"461647910672107650","title":"Transcription Regulation and Chromatin Remodeling","description":"The dominant terms point to regulation of transcription by RNA polymerase II and DNA-templated transcription, complemented by chromatin-related processes such as rDNA heterochromatin formation and histone acetylation. This suggests a cohesive theme around transcription control coupled with chromatin state, with a few peripheral terms. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0051017","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006355","count":2}]},{"hash":"1904123153643684362","title":"RNA Splicing and Translation Initiation","description":"Given the top GO terms, the cluster is enriched for translation initiation (translation reinitiation and formation of translation preinitiation complex) and RNA processing (mRNA splice site recognition), suggesting a functional group involved in preparing and initiating protein synthesis via RNA processing. While a few terms touch on developmental processes, the strongest shared signal centers on RNA metabolism and translation, justifying the label RNA Splicing and Translation Initiation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006376","count":2},{"id":"GO:0070586","count":1},{"id":"GO:0042074","count":1}]},{"hash":"794000407483506467","title":"Sterol and Fatty Acid Biosynthesis","description":"This cluster is dominated by lipid metabolism terms: cholesterol biosynthesis via lathosterol, ergosterol biosynthetic process, various sterol oxidations, fatty acid biosynthetic process, and related ether lipid metabolism. These converging lipid-related functions suggest a cohesive role in sterol and fatty acid biosynthesis, with a few outliers like sebaceous gland differentiation and CNS myelin maintenance that reflect tissue-specific lipid roles. Overall, the dominant theme is sterol and fatty acid synthesis across membranes and lipids.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046485","count":1},{"id":"GO:0006675","count":1},{"id":"GO:0001949","count":1},{"id":"GO:0080064","count":1},{"id":"GO:0033490","count":1}]},{"hash":"680237702906142084","title":"Developmental Regulation and Cellular Homeostasis","description":"The top terms span developmental processes (spinal cord development, placenta morphogenesis), cytoskeletal/microtubule movement, autophagy, and regulation of protein turnover and epigenetic programming. Together they point to a set of regulators that influence development while modulating gene expression, protein degradation, and intracellular trafficking, rather than a single specific pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0021510","count":3},{"id":"GO:0007018","count":3},{"id":"GO:0006914","count":2},{"id":"GO:1900458","count":2},{"id":"GO:2000059","count":2}]},{"hash":"737528796501016627","title":"Cortical Neuron Migration and Synapse Development","description":"This cluster is enriched for terms related to cerebral cortex development and neuron migration (layer formation in cerebral cortex; ventral spinal cord development; cerebral cortex tangential migration; positive regulation of lateral motor column neuron migration). It also includes receptor localization to synapse and increased excitatory postsynaptic potential, pointing to roles in synapse formation and cortical neuronal signaling. Additional transport terms (endosome-Golgi trafficking) are present but appear ancillary to the dominant neuronal development theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0042147","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0021819","count":1}]},{"hash":"379866961440803615","title":"Innate Immunity and Secretory Pathway","description":"The cluster combines innate immune terms (innate immune response; defense against Gram-negative bacteria and protozoa; cellular response to interferon-beta) with ER/secretory pathway processes (protein retention in ER lumen, protein transport, glycosylation). This suggests proteins involved in processing and secreting immune effectors, tying innate defense to the secretory machinery. Some terms like cuticle development and autophosphorylation regulation are less central to this theme, but do not override the core signal of immunity linked to secretion.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031953","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0097370","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0050829","count":1}]},{"hash":"598128658145584341","title":"Nucleobase and Urate Transport Across Plasma Membrane","description":"Most terms point to import and transport of nucleobases and related compounds (guanine, adenine, uracil, hypoxanthine, xanthine, urate) across the plasma membrane, indicating a transport-focused cluster. A couple of outlier terms about proteasome assembly and pinocytosis regulation are present but do not override the dominant transport theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098710","count":2},{"id":"GO:0098721","count":2},{"id":"GO:0035344","count":2},{"id":"GO:0042906","count":2},{"id":"GO:1903825","count":2}]},{"hash":"1195655357086046768","title":"TLR-Driven Innate Immune Activation","description":"Top GO terms indicate innate immune recognition and activation, with emphasis on lipopolysaccharide detection, Toll-like receptor 10 signaling, macrophage activation, dendritic cell cytokine regulation, and defense against bacteria. While a few non-immune annotations appear, the dominant signal points to a cluster of proteins involved in pathogen sensing and innate immune responses.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0032497","count":1},{"id":"GO:0002730","count":1},{"id":"GO:0050830","count":1},{"id":"GO:0042116","count":1}]},{"hash":"656501506475516469","title":"Autophagy Regulation under Oxidative Stress","description":"The cluster\u2019s GO terms cluster around autophagy (including mitochondrial autophagy) and oxidative stress response, with indications of survival signaling (AKT activation) and anti-apoptotic regulation. While a couple of terms (deglycosylation/deglycation) are less directly tied, the dominant themes point to cellular stress management via autophagy and prosurvival signaling.","confidence":"Medium","size":10,"edges":11,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":2},{"id":"GO:1903073","count":1},{"id":"GO:0006979","count":1},{"id":"GO:0006914","count":1},{"id":"GO:0006517","count":1}]},{"hash":"1661373143139461401","title":"Cardiovascular GPCR-cAMP Signaling and Coagulation","description":"Top GO terms indicate GPCR-mediated adenylate cyclase activation, calcium release, prostaglandin response, blood pressure regulation, vascular smooth muscle differentiation, and coagulation, suggesting a cohesive cardiovascular signaling and coagulation module. The electron transport chain term is less central but may reflect energy aspects of signaling; overall, the theme is vascular signaling with inflammatory/inflammatory-related regulation.","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0045777","count":9},{"id":"GO:0007190","count":9},{"id":"GO:0032651","count":8}]},{"hash":"2098090391330374660","title":"Sarcomere and Cytoskeletal Organization","description":"Most of the proteins have GO terms related to muscle architecture and sarcomeric organization (cardiac muscle contraction, skeletal muscle fiber development, sarcomere organization), plus cytoskeletal and membrane-associated processes (terminal web assembly). A few terms touch on trafficking and neuronal components, but the dominant signal points to muscle cytoskeleton organization and function, which inspired the name.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001837","count":2},{"id":"GO:1902896","count":2},{"id":"GO:0051000","count":2},{"id":"GO:1902966","count":2},{"id":"GO:0060048","count":2}]},{"hash":"2252460045779694302","title":"Inflammation and Coagulation Signaling","description":"This cluster centers on immune activation and coagulation/remodeling pathways, with terms like cellular response to interleukin-1, NF-kappaB signaling, adaptive immune response, and complement activation alongside platelet activation, plasminogen activation, and fibrinolysis. Angiogenesis and apoptotic processes further tie into tissue remodeling during inflammation. A minor, less connected term about glutamatergic synaptic transmission appears incidental.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":4},{"id":"GO:0007250","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0030168","count":3}]},{"hash":"1844305974840257178","title":"Axon Guidance and Ganglion Development","description":"This cluster is enriched for GO terms centered on axon guidance across multiple neuron types (retinal ganglion, commissural, sympathetic, branchiomotor, vestibulocochlear, dorsal root) and broader ganglion morphogenesis (facioacoustic, dorsal root). There is a secondary signal of vascular morphogenesis, but the dominant theme points to neuronal pathfinding and formation of cranial/sensory ganglia. Thus, the proteins likely function in neural wiring and ganglion development, justifying a label focused on axon guidance and ganglion development.","confidence":"High","size":10,"edges":31,"triangles":42,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060666","count":2},{"id":"GO:0048843","count":2},{"id":"GO:1902336","count":2},{"id":"GO:0071679","count":2},{"id":"GO:0097491","count":2}]},{"hash":"1687124447255030058","title":"ER Protein Folding and ERAD Quality Control","description":"The cluster\u2019s top GO terms cluster around endoplasmic reticulum handling of proteins, notably ER protein folding and chaperone-assisted refolding, plus ER-associated degradation (ubiquitin-dependent ERAD). This points to a cohesive theme of ER quality control and stress response. Peripheral terms such as apoptotic process, redox homeostasis, and others may reflect downstream stress signaling or cross-talk with broader cellular pathways, while a few terms appear more context-dependent.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0070389","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0070212","count":2}]},{"hash":"352233775092152778","title":"Unknown","description":"The top terms are spread across synaptic signaling, learning, development, chromatin modification, nucleotide biosynthesis, cilium movement, and differentiation, with no shared function or network connectivity among the proteins. Because there is no cohesive theme tying the proteins together, a meaningful single-label name cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":2},{"id":"GO:0007612","count":2},{"id":"GO:0030282","count":2},{"id":"GO:0051568","count":1},{"id":"GO:0021591","count":1}]},{"hash":"1691558674775511304","title":"Thermogenic GPCR-cAMP Calcium Signaling","description":"These proteins cluster around thermogenic and signaling processes: diet-induced thermogenesis, cellular response to temperature stimulus, and activation of adenylate cyclase via GPCRs, plus calcium release and electron transport, pointing to a thermogenesis-linked GPCR-cAMP-calcium signaling theme. Some GO terms touch xenobiotic response, IL-1 beta regulation, and blood pressure, which may reflect broader stress and inflammatory signaling present in the same proteins but are not central to the main theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3}]},{"hash":"89566284623813627","title":"Amino acid and GABA transport","description":"This cluster is largely defined by membrane transport terms for amino acids (lysine, arginine, leucine) and gamma-aminobutyric acid, plus related transmembrane transport regulation (e.g., carnitine). A couple of macrophage activation terms appear incidental and do not define the main function. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015812","count":1},{"id":"GO:0097639","count":1},{"id":"GO:0043030","count":1},{"id":"GO:0042116","count":1},{"id":"GO:0097638","count":1}]},{"hash":"1966786525506459567","title":"Angiogenesis Regulation and Endothelial Function","description":"The top GO terms are dominated by angiogenesis and its regulation, including both positive and negative regulation, plus endothelial migration, blood vessel biology, and coagulation-related processes. This points to a vascular biology cluster focused on how blood vessels grow and remodel, with supporting signals from endothelial and innate immune pathways. Some terms related to exocytosis and lipid homeostasis likely reflect endothelial secretory and metabolic roles, but the core theme remains angiogenesis and vascular endothelium signaling.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0016525","count":5},{"id":"GO:0045921","count":5},{"id":"GO:0045907","count":5},{"id":"GO:0070328","count":5}]},{"hash":"2024095708001486455","title":"Unknown","description":"The top GO terms cover diverse processes with little overlap: synapse assembly, endosome/phagosome dynamics, spermatogenesis, APP biosynthesis regulation, embryonic cleavage, rRNA maturation, nucleotide and thiamine metabolism, and oxidative regulation. Because there is no dominant function or pathway linking the majority of terms, and the cluster has no edges, it appears to be a mixed set rather than a cohesive module. Therefore the label Unknown with None.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0007032","count":1},{"id":"GO:0044655","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0042985","count":1}]},{"hash":"2166724350301148486","title":"Neural development and ECM adhesion","description":"This cluster\u2019s top GO terms cluster around developmental processes, notably neural development (astrocyte development, fasciculation of sensory neuron axon, neuron remodeling) and extracellular matrix\u2013related interactions (ECM disassembly, substrate adhesion\u2013dependent spreading, heterophilic adhesion), with additional broad development terms (system, somite, and hair follicle development). The common thread appears to be development shaped by cell adhesion and ECM remodeling, with a neural emphasis.","confidence":"Medium","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0014002","count":5},{"id":"GO:0097155","count":5},{"id":"GO:0016322","count":5},{"id":"GO:0001942","count":5},{"id":"GO:0022617","count":5}]},{"hash":"1227285430918910612","title":"Unknown","description":"The listed GO terms cover oxidative stress, metabolism, cell division, signaling, defense, and development across potentially different species, with no clear shared function or strong connectivity among the proteins. This lack of a cohesive theme or interaction pattern makes a concise, representative label unreliable.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":3},{"id":"GO:2000531","count":2},{"id":"GO:0090526","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0010288","count":2}]},{"hash":"147440675100343112","title":"Nuclear RNA Processing and Ribosome Export","description":"This cluster is dominated by GO terms for mRNA export from the nucleus, ribosomal subunit export, and tRNA processing, plus import of RNA-binding/splicing-related proteins into the nucleus, which together point to a cohesive role in nuclear RNA maturation and ribosome biogenesis/export. A few terms touch on centrosome/kinetochore regulation, but the strongest signal is nuclear RNA processing and ribosome transport.","confidence":"Medium","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":5},{"id":"GO:0008033","count":3},{"id":"GO:0000056","count":3},{"id":"GO:0035048","count":3},{"id":"GO:0010824","count":3}]},{"hash":"704918838616290879","title":"Unknown","description":"The top GO terms span DNA repair, oxidative stress regulation, glial proliferation, T-helper 2 differentiation, p38MAPK signaling, IL-13 production, cell junction maintenance, epithelial polarity establishment, endothelial apoptosis, and neural development, with no single unifying function evident. The breadth suggests multiple distinct roles or annotation noise rather than a cohesive cluster function.","confidence":"","size":10,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006284","count":2},{"id":"GO:0010310","count":1},{"id":"GO:0060252","count":1},{"id":"GO:0045630","count":1},{"id":"GO:1900745","count":1}]},{"hash":"1062054927766276868","title":"RNA export and helicase activity regulation","description":"This cluster is characterized by GO terms linked to poly(A)+ mRNA export from the nucleus and to positive regulation of helicase activity, plus a broad cue for ATP-dependent activity. The combination suggests a functional module in RNA processing/export and control of RNA helicases. The sparse connectivity (one edge, no triangles) and the note about proteins re-added by RECIPE imply a small, cohesive group with a common RNA-related role, supporting this naming.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":1},{"id":"GO:0016973","count":1},{"id":"GO:0051096","count":1}]},{"hash":"1621201952181121733","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0071375","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0006260","count":2}]},{"hash":"671922441854253816","title":"Viral integration and proviral latency","description":"The top GO terms cluster around DNA recombination, DNA integration, RNA-templated DNA biosynthesis, DNA replication, and explicit processes like establishment of integrated proviral latency and viral entry into host cells, which together point to retroviral-like genome integration and persistence in the host. Additional terms about host nucleus entry, symbiont-mediated host effects, and regulation of the cell cycle further support viral manipulation of the host to facilitate replication and latency, with possible suppression of host RNAi defenses. Confidence is High","confidence":"","size":10,"edges":19,"triangles":16,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0006278","count":2}]},{"hash":"1605482646026953927","title":"Plant cell wall synthesis and root hair development","description":"Most top GO terms point to plant-specific processes, including root hair development, cell wall organization, and rhamnogalacturonan II biosynthesis, suggesting a cohesive theme of plant cell wall construction and related development (with stilbenoid response supporting plant defense). The presence of a few immune signaling terms (lymphocyte/macrophage chemotaxis, IL-1 production, I-kappaB phosphorylation, calcium regulation) appears discordant and likely represents annotation noise or cross-species artifacts. Overall, the dominant signal is plant cell wall\u2013related function.","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0080147","count":1},{"id":"GO:0010306","count":1},{"id":"GO:0071555","count":1},{"id":"GO:0048247","count":1},{"id":"GO:0050918","count":1}]},{"hash":"1361240737410950471","title":"Unknown","description":"This cluster shows a mix of immune-related regulatory GO terms (negative regulation of IL-2 signaling, TLR9 signaling, and p38MAPK, plus granzyme B production) with a couple of unrelated terms (vestibular morphogenesis and an obsolete mitotic cycle term). The functions do not converge on a single coherent biological theme, so there is no reliable unifying label beyond Unknown.","confidence":"","size":10,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902206","count":1},{"id":"GO:2000646","count":1},{"id":"GO:0060116","count":1},{"id":"GO:0071225","count":1},{"id":"GO:0033629","count":1}]},{"hash":"1949652416782714437","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030490","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0045948","count":1},{"id":"GO:0034402","count":1}]},{"hash":"1621022221216626381","title":"Neuronal excitability and synaptic transmission","description":"The top GO terms concentrate on potassium and sodium ion transmembrane transport, membrane depolarization, excitatory postsynaptic potentials, and neuronal action potential propagation, with a focus on regulation of synaptic transmission. This points to a cluster of proteins involved in neuronal signaling and excitability. A few terms relate to other processes like tight junctions or vasculogenesis, but the dominant pattern is neuronal signaling.","confidence":"High","size":10,"edges":17,"triangles":15,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0051899","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0070830","count":3}]},{"hash":"1677604452919291408","title":"Plant metabolism and defense signaling","description":"The top GO terms cover amino acid biosynthesis (tyrosine, phenylalanine, lysine), biotin and fatty acid-related processes, and catabolic pathways like kynurenine, alongside plant-specific processes such as fruit ripening and systemic acquired resistance via salicylic acid. This pattern suggests a cluster centered on plant primary metabolism integrated with signaling and defense responses, rather than a single narrow pathway. ","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055089","count":4},{"id":"GO:0006571","count":4},{"id":"GO:0032869","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0097053","count":4}]},{"hash":"1082101537884884559","title":"Mitotic spindle and microtubule dynamics","description":"The GO terms cluster around microtubule-based processes\u2014plus- and minus-end directed sliding, kinetochore attachments, metaphase chromosome alignment, and microtubule polarity\u2014indicating proteins involved in spindle organization and mitotic progression, with a few peripheral terms related to chloroplast movement or junction maintenance.","confidence":"High","size":10,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009904","count":2},{"id":"GO:0031534","count":2},{"id":"GO:0048364","count":2},{"id":"GO:0060404","count":2},{"id":"GO:0033624","count":2}]},{"hash":"286615618731430817","title":"Insect cuticle pigmentation and xenobiotic response","description":"The top GO terms center on adult chitin-containing cuticle pigmentation and its regulation, suggesting a pigmentation-focused cluster. Additional terms point to xenobiotic and alkaloid responses (pyrethroid, alkaloid, xenobiotic stimulus) and related signaling, which together indicate a link between pigment-related pathways and detox/response processes in insects. The combination implies a coherent theme around pigment production in the adult insect cuticle with concurrent detox/response signaling.","confidence":"High","size":10,"edges":12,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048085","count":2},{"id":"GO:0006587","count":2},{"id":"GO:0048082","count":2},{"id":"GO:0046684","count":2},{"id":"GO:0042136","count":2}]},{"hash":"1141482755275013607","title":"Ribosome biogenesis and nucleotide metabolism","description":"Top GO terms cluster around ribosomal processes (translation, translational termination, ribosomal large subunit assembly) and nucleotide metabolism (dGTP metabolic process, deoxyguanosine salvage, DNA biosynthetic process), with some signals of energy-related respiration (mitochondrial electron transport, ubiquinone biosynthesis). This combination suggests a functional module focused on ribosome biogenesis and nucleotide metabolism, with some ancillary links to energy production pathways. ","confidence":"Medium","size":10,"edges":41,"triangles":91,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0071897","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0006744","count":1},{"id":"GO:0006415","count":1}]},{"hash":"117045765709776237","title":"Calcium-dependent signaling and cytoskeletal dynamics in development","description":"These terms cluster around calcium-regulated signaling pathways (Wnt/Ca2+, calcium channel regulation, Ca2+-dependent processes) and cytoskeletal remodeling (actomyosin contractile structures, cytoskeleton-dependent transport, EMT). The presence of developmental processes (kidney/organ development) and muscle contraction further supports a unifying theme: Ca2+-driven signaling coordinating cytoskeletal dynamics during development and morphogenesis.","confidence":"High","size":10,"edges":35,"triangles":63,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001837","count":10},{"id":"GO:0007223","count":10},{"id":"GO:0035774","count":10},{"id":"GO:1901841","count":10},{"id":"GO:0035191","count":10}]},{"hash":"495917796223378325","title":"Embryonic Development and Organ Morphogenesis","description":"This cluster\u2019s top GO terms cluster around developmental and morphogenetic processes across multiple organs\u2014embryo development, general organ morphogenesis, and specific cardiac development (aortic valve morphogenesis, endocardial cushion cell development) as well as kidney development (loop of Henle). Other terms touch on reproductive and extracellular matrix processes, with a few general physiology signals. Overall, the dominant theme is developmental/morphogenetic activity across tissues, especially heart-related development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006508","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0003180","count":3},{"id":"GO:0072070","count":3}]},{"hash":"100230366094815032","title":"Retroelement Transposition and Proviral Integration","description":"The cluster is defined by GO terms for DNA transposition, DNA integration, RNA-templated DNA biosynthesis, and establishment of integrated proviral latency, indicating retroelement/transposon activity and genome integration; accompanying translation/rRNA processes appear as background.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0006313","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0002181","count":2}]},{"hash":"1496358081473275609","title":"RNA Splicing Regulation and mRNA Decay","description":"This cluster is strongly enriched for GO terms tied to RNA processing: regulatory ncRNA-mediated gene silencing, positive regulation of splicing via the spliceosome, cis-splicing via the spliceosome, and nonsense-mediated decay, indicating a core theme of RNA metabolism and transcript quality control. A few terms (DNA replication, signaling, adhesion) appear tangentially, but the dominant signal is RNA splicing regulation and mRNA surveillance.","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0045292","count":3},{"id":"GO:0000184","count":3},{"id":"GO:0006260","count":3}]},{"hash":"711372662990791574","title":"Immune signaling modulation","description":"The cluster centers on regulation of immune signaling pathways (IL-2, TLR9, p38 MAPK) and cytotoxic effector function (granzyme B production), with additional links to pathogen sensing and receptor signaling. This pattern suggests a theme of tuning immune responses rather than a single metabolic or structural function, despite one unrelated vestibular term present. ","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902206","count":2},{"id":"GO:2000646","count":2},{"id":"GO:0060116","count":2},{"id":"GO:0071225","count":2},{"id":"GO:0033629","count":2}]},{"hash":"159313730845996872","title":"DNA replication and chromatin assembly","description":"Top GO terms point to DNA replication, centromeric chromatin assembly (CENP-A) and regulation of replication initiation, indicating a core theme around genome duplication and chromatin organization during the cell cycle. Additional terms cover cell division, microtubule severing, and ER-to-Golgi transport, suggesting broader mitotic and cellular logistics in this cluster. Taken together, the proteins likely participate in replication and chromatin assembly tasks along with mitotic progression.","confidence":"Medium","size":10,"edges":23,"triangles":17,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0061641","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0051301","count":3}]},{"hash":"935628664512611865","title":"Neurodevelopment and Growth Factor Signaling","description":"The cluster centers on neural development terms (hippocampus development; neuron apoptotic regulation) and signaling pathway modulation (TGF-\u03b2 signaling, BMP signaling). Dephosphorylation terms (protein and peptidyl-threonine dephosphorylation) suggest regulation of signaling cascades, with sprouting angiogenesis aligning with growth factor\u2013driven development. A few terms like meristem identity and exosomal secretion are less related, but the core theme points to neural development coordinated with growth-factor signaling.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043525","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0002040","count":2},{"id":"GO:1903542","count":2},{"id":"GO:0010074","count":1}]},{"hash":"585944897941037554","title":"ER Stress and Protein Folding","description":"The cluster is dominated by GO terms related to handling and quality control of proteins in the secretory pathway, including cellular response to unfolded proteins, SRP-dependent cotranslational targeting to the ER membrane, and chaperone-assisted protein refolding. These together point to ER-associated protein folding and trafficking as the core function, with some secondary signals like oxidative stress\u2013related apoptosis and fungal-specific processes appearing as less central signals. ","confidence":"High","size":10,"edges":40,"triangles":83,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":4},{"id":"GO:1903382","count":4},{"id":"GO:0006880","count":4},{"id":"GO:0016226","count":4},{"id":"GO:0034620","count":4}]},{"hash":"523395510589298222","title":"Immune signaling and defense responses","description":"The GO terms are dominated by immune-related processes: lipopolysaccharide-mediated signaling, defense response to Gram-positive bacteria, and positive regulation of IL-4 production, pointing to cytokine signaling and immune activation. While there are a few development- or endothelial/apoptotic terms, the overall theme centers on immune signaling and inflammatory defense, making this label a concise summary of the cluster\u2019s function. ","confidence":"Medium","size":10,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031663","count":2},{"id":"GO:1900074","count":1},{"id":"GO:0048535","count":1},{"id":"GO:0048566","count":1},{"id":"GO:0072577","count":1}]},{"hash":"1693803228113437622","title":"Neural signaling and locomotor behavior","description":"These proteins are annotated with neural communication and movement-related functions, such as serotonin receptor signaling, dopamine secretion, cholinergic and micturition-related synaptic transmission, and membrane depolarization. The presence of brain development terms (lateral geniculate nucleus and vestibulocochlear nerve development) alongside locomotory behavior and autonomic regulation (heart rate response) points to a cluster centered on neuronal signaling and motor/behavior outputs.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0033603","count":6},{"id":"GO:0001988","count":6},{"id":"GO:0021771","count":6}]},{"hash":"477149344227711795","title":"Immune and Neural Development Signaling","description":"The cluster contains GO terms indicating immune signaling (Th1 type response, T cell receptor signaling, IL-23 regulation), neural development and guidance (brain development, Roundabout/ROBO signaling, Smoothened pathway), and broader signaling cascades (JNK regulation, mechanotransduction). This combination suggests a theme of signaling pathways that influence development and immune responses across tissues, rather than a single, tightly focused function.","confidence":"Medium","size":10,"edges":16,"triangles":16,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046330","count":4},{"id":"GO:0042088","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0032707","count":4},{"id":"GO:0007224","count":4}]},{"hash":"960670931818626557","title":"Autophagy and Epigenetic Regulation","description":"The top GO terms highlight autophagy as a central function, with multiple entries tied to regulation of proteostasis (ubiquitin-dependent protein catabolic process), and epigenetic programming of gene expression. Additional terms touch on development (placenta morphogenesis) and immune-related processes (MHC I biosynthesis, NF-kappaB), suggesting a cluster that links autophagy with chromatin-level gene regulation and broader cellular regulation rather than a single pathway. Some terms appear species- or context-specific, but the core signal points to autophagy-related regulation and epigenetic control as the unifying theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":8},{"id":"GO:1900458","count":8},{"id":"GO:2000059","count":8},{"id":"GO:0060669","count":8},{"id":"GO:1901536","count":8}]},{"hash":"1152036694264530967","title":"Innate antiviral NF-\u03baB signaling cluster","description":"This cluster is best described by the strong representation of innate immune and antiviral terms, notably defense response to virus, innate immune response, and positive regulation of canonical NF-\u03baB signaling. These converge on NF-\u03baB\u2013mediated antiviral signaling. Autophagy and ubiquitin-related regulation further support immune signaling cross-talk, while other terms may reflect broader regulatory connections rather than a separate function. Overall, the core theme is innate antiviral signaling through NF-\u03baB.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0006914","count":4}]},{"hash":"1947529573066750217","title":"Autophagy and Immune Signaling Regulators","description":"The cluster\u2019s top terms center on autophagy and immune-related signaling, including positive regulation of IL-17 signaling, antiviral transport regulation, and ubiquitin-dependent proteolysis, suggesting proteins that modulate stress responses and immune pathways. Some terms appear plant- or development-focused, but the predominant theme is regulation of autophagy and immune signaling processes.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0006914","count":3},{"id":"GO:1900458","count":3},{"id":"GO:0072089","count":3},{"id":"GO:2000059","count":3}]},{"hash":"2076069778149963140","title":"Mitotic progression and cell division","description":"Based on the top GO terms, the cluster is enriched for transitions into and out of mitosis (G1/S, G2/M, re-entry into cell cycle), spindle pole separation, chromosome condensation, and general cell division. This suggests a core function in mitotic control and proliferation. While there are growth signaling terms (insulin signaling, leptin response), the dominant theme is mitotic progression.","confidence":"High","size":10,"edges":9,"triangles":4,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000086","count":9},{"id":"GO:0010696","count":9},{"id":"GO:0046626","count":9},{"id":"GO:0033598","count":9},{"id":"GO:0000082","count":9}]},{"hash":"570390954736398673","title":"Ubiquitin-Dependent Cell Cycle Regulation","description":"This cluster centers on cell cycle control, with terms for G1/S and G2/M transitions, mitosis, and regulation of the cell cycle, alongside ubiquitin-mediated processes (polyubiquitination, ERAD, and ubiquitin-dependent protein catabolic processes). The convergence of cell-cycle progression and ubiquitin-dependent degradation suggests proteins that regulate mitosis by tagging key regulators for proteasomal turnover, possibly coupled with transcriptional regulation in cell-cycle control. ","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0042787","count":3}]},{"hash":"1988227481198565531","title":"Mitochondrial respiration and NAD/NADH metabolism","description":"The top GO terms cluster around mitochondrial energy production: tricarboxylic acid cycle, mitochondrial electron transport (NADH to ubiquinone), 2-oxoglutarate metabolism, and nicotinamide nucleotide metabolism. These indicate a focus on respiration and redox cofactor turnover within mitochondria. A few peripheral terms (folate metabolism, RNA decapping) are less connected to the core function, suggesting some noise but not overriding the dominant mitochondrial energy theme.","confidence":"High","size":10,"edges":15,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006099","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0006103","count":2},{"id":"GO:0046496","count":1}]},{"hash":"357845228756227842","title":"Diverse Metabolic Biosynthesis and Degradation","description":"This cluster's top GO terms span triglyceride catabolism, biotin and antibiotic biosynthesis, beta-ketoadipate and uracil catabolism, nitrogen utilization, and P450-related oxidation pathways. Together they point to broad metabolic capabilities (both biosynthesis and degradation) rather than a single tight function. The lack of edges suggests the proteins contribute to various metabolic processes, so the label reflects a general metabolic theme rather than a specific pathway.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":6},{"id":"GO:0042952","count":5},{"id":"GO:0009102","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0017000","count":5}]},{"hash":"1667520584750400916","title":"Immune activation and leukocyte recruitment","description":"This cluster shows a strong representation of immune-related GO terms: phagocytosis recognition, basophil activation, leukocyte tethering/rolling, and regulation of NK cell chemotaxis, as well as responses to fungal molecules, indicating innate immune activation and leukocyte recruitment. A few terms relate to developmental processes (cartilage condensation, metanephric morphogenesis, mesonephric duct development), which may be annotations from broader signaling pathways or cross-annotation. Overall, the dominant signal is immune cell activation and trafficking. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001502","count":7},{"id":"GO:0006910","count":7},{"id":"GO:0010572","count":7},{"id":"GO:0045575","count":7},{"id":"GO:0050901","count":7}]},{"hash":"1156367258729212247","title":"Unknown","description":"The Top Terms are highly heterogeneous, covering animal development (male sex differentiation, prostate gland development), hormone signaling (steroid hormone receptor complex assembly), plant metabolism (photosynthesis), immune response (cellular response to type I interferon), and various metabolic/process terms, with no clear shared function or cohesive biological theme. The lack of interactions (Edges: 0, Triangles: 0) further supports that no single unifying function ties the cluster together, so an Unknown label is most appropriate.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0046661","count":4},{"id":"GO:0006463","count":4},{"id":"GO:0015979","count":4},{"id":"GO:0030850","count":4},{"id":"GO:0071357","count":4}]},{"hash":"859222722695405708","title":"Motor neuron differentiation and axon guidance","description":"Cluster centered on neuronal development, especially motor neuron differentiation and axon guidance. The top GO terms point to various motor neuron lineages (motor column, visceral/motor neuron differentiation), cerebellar and midbrain neuronal differentiation, and axon guidance, consistent with a group of proteins involved in neural connectivity and growth cone dynamics (supported by actin filament regulation). A few terms related to cardiac development or fungal cell wall biosynthesis appear less representative. ","confidence":"High","size":10,"edges":16,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055014","count":2},{"id":"GO:0021524","count":2},{"id":"GO:0030835","count":2},{"id":"GO:1904948","count":2},{"id":"GO:0090334","count":2}]},{"hash":"105061809959941355","title":"Diverse Membrane Transport","description":"The Top Terms overwhelmingly point to transmembrane transport across a variety of substrates (xenobiotics, nitrite, ions, sugars, vitamins, and related metabolites). This pattern indicates a cluster of transporter proteins with broad substrate specificity rather than a single substrate focus. The lack of network edges does not change this functional theme, so a label centered on membrane transport is most representative.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0015739","count":2}]},{"hash":"1916050433273917599","title":"Neurodevelopment and cholinergic signaling","description":"The GO terms repeatedly point to nervous system development and neuron\u2013glia interactions: axon guidance, retina development, Schwann cell development, radial glia migration, and cholinergic signaling components. These collectively suggest a cluster centered on neural development and acetylcholine-related signaling, with a few peripheral development terms (podocytes, brown fat, lung) that are less central to the theme.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1905815","count":1},{"id":"GO:0072249","count":1},{"id":"GO:0043113","count":1},{"id":"GO:0032224","count":1},{"id":"GO:0014044","count":1}]},{"hash":"1662960705811532951","title":"Glycosylation and proteoglycan biosynthesis","description":"The cluster is dominated by GO terms related to glycosylation and carbohydrate modification (protein glycosylation, fucosylation, keratan sulfate proteoglycan biosynthetic process, L-fucose catabolic process), with a clear emphasis on keratan sulfate proteoglycans. Additional terms touch on neural development and immune cell movement, which can be influenced by extracellular matrix glycoproteins and glycans. Overall, the set likely represents glycan biosynthesis and proteoglycan formation, with secondary links to neural and immune processes, despite some obsolete annotations.","confidence":"Medium","size":10,"edges":21,"triangles":13,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":4},{"id":"GO:0005975","count":2},{"id":"GO:0036065","count":2},{"id":"GO:0018146","count":2},{"id":"GO:0021799","count":1}]},{"hash":"161044584836745883","title":"ER-Golgi Transport and Wnt Secretion","description":"Dominant terms center on ER-to-Golgi vesicle traffic and COPI-coated vesicles (COPI coating, budding, ER lumen retention) and specifically on regulation of Wnt protein secretion, suggesting the core function is the secretory pathway and Wnt signaling. Some developmental terms (axis specification, placental development) likely reflect downstream roles of Wnt signaling or maternal-effect processes, but the primary theme is vesicle trafficking in the early secretory pathway and Wnt secretion.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0048205","count":2},{"id":"GO:0035964","count":2},{"id":"GO:0032525","count":2},{"id":"GO:0061357","count":2}]},{"hash":"1763518876137553883","title":"Innate Immunity and Autophagy","description":"The top GO terms are dominated by innate immune response and autophagy, including IL-17\u2013mediated signaling and ubiquitin-related regulation, suggesting the proteins participate in immune regulation and cellular waste processing. Some terms relate to RNA metabolism and broader developmental signals, which may reflect annotation breadth rather than core function for this cluster. Overall, the cluster centers on innate immune mechanisms with autophagy involvement.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0006914","count":6},{"id":"GO:1900458","count":6},{"id":"GO:0072089","count":6}]},{"hash":"2124441236575455805","title":"Ribosome Biogenesis and Translation","description":"The dominant GO terms center on ribosome biogenesis (large subunit biogenesis, ribosome biogenesis) and translation, indicating a core role in making and translating ribosomes. The presence of mRNA export from the nucleus suggests coordination between transcription/export and ribosome production, while a few transcription and trafficking terms imply broader RNA metabolism and vesicle-related processes accompanying protein synthesis. Overall, the cluster appears to reflect components involved in ribosome assembly and mRNA translation, with ancillary links to RNA processing and trafficking.","confidence":"Medium","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0070676","count":2},{"id":"GO:0001172","count":1}]},{"hash":"1089471556150219098","title":"Immune signaling and cell adhesion","description":"The top terms cluster around immune cell communication (neutrophil chemotaxis; B cell receptor signaling; NK cell-mediated cytotoxicity) and adhesion processes (integrin signaling; epithelial and zonula adherens cell-cell adhesion), suggesting a theme of immune signaling coupled with adhesion interactions. A few terms are more general or unrelated (e.g., neuron projection development), indicating the connection is not perfectly tight, so the label is plausible but not definitive.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":1},{"id":"GO:0045218","count":1},{"id":"GO:0034453","count":1},{"id":"GO:0007229","count":1},{"id":"GO:0043552","count":1}]},{"hash":"493365694338765726","title":"Synaptic Vesicle Fusion and Golgi Trafficking","description":"The top GO terms point to vesicle docking, priming, and fusion in synapses, plus transport between endosomes and the Golgi and vesicle fusion events involving the Golgi and presynaptic membranes. Norepinephrine secretion and Golgi disassembly further support a secretory/trafficking role. Collectively, these terms describe a cluster centered on neuronal vesicle trafficking and the secretory pathway, especially at the synapse and Golgi/endosome interfaces.","confidence":"High","size":9,"edges":11,"triangles":0,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0051469","count":4},{"id":"GO:0010807","count":4},{"id":"GO:0016081","count":4},{"id":"GO:0090166","count":4},{"id":"GO:0045022","count":4}]},{"hash":"112970429366732416","title":"Apoptosis and Immune Response","description":"The cluster is dominated by terms related to programmed cell death (execution phase of apoptosis, apoptotic nuclear changes, apoptotic signaling) and immune/inflammatory signaling (response to TNF, response to lipopolysaccharide), with supportive stress signaling (DNA damage checkpoint). While a few terms reference development or sensory processes as outliers, the core theme centers on apoptosis and inflammatory response under cellular stress.","confidence":"Medium","size":9,"edges":12,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048535","count":1},{"id":"GO:0097296","count":1},{"id":"GO:0030262","count":1},{"id":"GO:0097194","count":1},{"id":"GO:0000077","count":1}]},{"hash":"1849108565955313642","title":"Mitochondrial dynamics and vesicle trafficking","description":"These proteins cluster around mitochondrial behavior (mitochondrion inheritance, intracellular distribution of mitochondria) and vesicle/secretory processes (exosomal secretion, conjugation with cellular fusion), suggesting a core role in mitochondrial dynamics and intercellular trafficking. Additional GO terms tied to energy-demanding heart contraction and anti-apoptotic signaling in neurons fit with mitochondria-dependent regulation of survival and contractile function, while terms related to cell adhesion/migration hint at cytoskeletal transport and vesicle movement. Overall, the common theme appears to be organelle dynamics coupled with vesicle-mediated communication.","confidence":"Medium","size":9,"edges":19,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0060047","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0060355","count":2}]},{"hash":"1049884770328744829","title":"Cardiovascular and limb development","description":"The top GO terms cluster around heart development, cardiac myofibril assembly, and angiogenesis, with supporting terms for limb development and related growth processes, suggesting the proteins are involved in cardiovascular and limb development rather than a single molecular function.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0071456","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0001824","count":2},{"id":"GO:0008284","count":2}]},{"hash":"288192954816752628","title":"Ubiquitin-mediated innate immune signaling","description":"The top GO terms point to innate immune response and ubiquitin-related regulation (K63-linked ubiquitination, autoubiquitination, ubiquitin-dependent proteolysis), along with TNF/NF-kappaB signaling and apoptotic regulation. This combination suggests a cohesive set of proteins involved in ubiquitin-modulated innate immune signaling and antiviral responses.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901253","count":5},{"id":"GO:0051092","count":5},{"id":"GO:1903265","count":5},{"id":"GO:0070534","count":5},{"id":"GO:1903762","count":5}]},{"hash":"348585205034611778","title":"Meiotic chromosome pairing and cohesion","description":"The GO terms focus on meiotic chromosome events\u2014homologous pairing, sister chromatid cohesion during meiosis I (centromeric), and linear element/axis assembly\u2014besides general cell division, indicating a cluster centered on meiotic chromosome cohesion and pairing mechanisms.","confidence":"High","size":9,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032876","count":1},{"id":"GO:0031619","count":1},{"id":"GO:0010789","count":1},{"id":"GO:0061781","count":1},{"id":"GO:0051754","count":1}]},{"hash":"2173409022388165917","title":"Developmental regulation and stress responses","description":"Most terms emphasize development and gene regulation (multicellular development, neural tube closure, skeletal development, DNA-templated transcription, imprinting regulation) with additional signals for cellular stress and apoptosis (ER stress\u2013induced intrinsic apoptotic pathway, cadmium response, defense response). This suggests a cluster centered on developmental gene regulation with associated stress responses, rather than a single specific pathway.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0001403","count":5},{"id":"GO:0001843","count":5},{"id":"GO:0071276","count":5}]},{"hash":"879467986583976194","title":"Organ morphogenesis and tissue development","description":"The cluster shows GO terms tied to development and organogenesis in multiple tissues (pancreas, kidney/nephron, lung, umbilical cord, brain), plus patterning/differentiation terms, pointing to a common theme of tissue formation and cell fate specification rather than a single pathway. A couple of outliers (DNA repair, xenobiotic response) exist but do not override the main developmental signal.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0003326","count":7},{"id":"GO:0003053","count":7},{"id":"GO:0048712","count":7},{"id":"GO:0071400","count":7},{"id":"GO:0009410","count":7}]},{"hash":"900899452301462938","title":"Cell Cycle and Ubiquitin-Dependent Proteolysis","description":"The top GO terms are dominated by core cell-cycle processes (cell cycle, DNA replication, mitotic cell cycle, cell division) and proteostasis via ubiquitination and proteasomal degradation (SCF-dependent ubiquitin pathways, ERAD, protein ubiquitination). This suggests a cluster centered on cell-cycle progression tightly coordinated with regulated protein degradation, with a possible nod to ciliogenesis (cilium assembly) as related to cell-cycle control.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0060271","count":2}]},{"hash":"1685012428741958628","title":"Innate immune activation and leukocyte trafficking","description":"The top GO terms cluster around innate immunity and leukocyte behavior: complement activation via the lectin pathway, phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and negative regulation of NK cell chemotaxis. While cartilage condensation and mesonephric duct development appear in the list, the dominant signal is innate immune activation and leukocyte recruitment, suggesting the proteins\u2019 primary role is in inflammatory defense and cell trafficking.  ","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0001502","count":4},{"id":"GO:0006910","count":4},{"id":"GO:0010572","count":4},{"id":"GO:0045575","count":4}]},{"hash":"1221042619433468204","title":"Neurotransmitter and nutrient membrane transporters","description":"The top GO terms are dominated by transmembrane transport activities for diverse substrates (glucose, myo-inositol, pantothenate, biotin, glycine) and neurotransmitter-related uptake/secretion, along with sodium export. This pattern indicates a cluster of membrane transport proteins (likely solute carriers) that mediate substrate movement across the plasma membrane, with a neurochemical context suggested by acetylcholine biosynthesis and glycine/serotonin terms.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008292","count":2},{"id":"GO:0071436","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0015798","count":2},{"id":"GO:0015887","count":2}]},{"hash":"1855891835761115490","title":"Macrophage and dendritic cell immune activation","description":"The GO terms cluster around innate immunity (macrophage activation, dendritic cell cytokine regulation, defense against Gram-positive bacteria, and LPS detection), with additional signals of cell adhesion and actin remodeling that support immune cell migration and phagocytosis; a couple of developmental terms appear to reflect annotation spillover, but the dominant theme is immune activation in innate immune cells.","confidence":"High","size":9,"edges":31,"triangles":55,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060658","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0007156","count":1},{"id":"GO:0032497","count":1},{"id":"GO:0002730","count":1}]},{"hash":"609800230265902374","title":"Unknown","description":"The enriched GO terms span neural development, neurotransmitter biosynthesis, immune and stress responses, epigenetic regulation, and metal ion responses, with no single dominant process. The cluster also has no edges or connections, suggesting no coherent functional linkage among proteins; thus a specific label cannot be derived.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042416","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0010725","count":2},{"id":"GO:0014063","count":2}]},{"hash":"342931439192677663","title":"Lipid mediator biosynthesis and xenobiotic metabolism","description":"The cluster includes GO terms for prostaglandin biosynthesis and epoxygenase P450 pathways, plus xenobiotic and camphor catabolic processes, all pointing to lipid mediator production and xenobiotic metabolism. The presence of related immune and reproductive terms likely reflects broader roles or pleiotropy, but the core theme remains metabolic processing of lipids and xenobiotics. ","confidence":"Medium","size":9,"edges":26,"triangles":35,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":7},{"id":"GO:0019383","count":5},{"id":"GO:0035865","count":4},{"id":"GO:1900087","count":4},{"id":"GO:0033072","count":4}]},{"hash":"543818454441711044","title":"Autophagy-Linked Immune Regulation","description":"Top GO terms cluster around autophagy, epigenetic programming, and immune-related processes (MHC class I biosynthesis, NF-kappaB regulation) with links to viral interactions, suggesting a shared function in cellular quality control and immune signaling where autophagy intersects with antigen presentation and gene expression. Some terms appear plant- or development-focused, so the core theme is inferred from the stronger autophagy and immune-related annotations.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":4},{"id":"GO:1900458","count":4},{"id":"GO:2000059","count":4},{"id":"GO:0060669","count":4},{"id":"GO:1901536","count":4}]},{"hash":"1591099079712881720","title":"Acetyl-CoA production and fatty acid biosynthesis","description":"This set centers on acetyl-CoA production from multiple inputs (pyruvate, leucine) and its use in lipid synthesis. GO terms include pyruvate dehydrogenase activity, glycolysis, gluconeogenesis, malonyl-CoA biosynthesis, and long-chain fatty acid biosynthesis, plus leucine catabolism to acetyl-CoA. Together these indicate mitochondrial central carbon metabolism driving energy production and fatty acid biosynthesis. Confidence in this label is High.","confidence":"","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006086","count":4},{"id":"GO:0006213","count":4},{"id":"GO:0033512","count":4},{"id":"GO:0006096","count":4},{"id":"GO:0042759","count":4}]},{"hash":"1616330660741444568","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":27,"triangles":39,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0000398","count":5},{"id":"GO:0030260","count":4}]},{"hash":"248671440609150576","title":"RNA processing and translation initiation complex","description":"The proteins are enriched for mRNA maturation and export (polyadenylation, small-subunit processome, mRNA export), spliceosome-associated regulation, and initiation of translation (preinitiation complex formation, EF4F complex assembly, IRES-dependent initiation), indicating a cohesive cluster of RNA processing and translation machinery, with some ncRNA-mediated regulatory interactions.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0048026","count":3},{"id":"GO:1901407","count":3}]},{"hash":"90267507791630454","title":"Mitochondrial Transport and Metabolic Shuttles","description":"This cluster centers on transport of metabolites across the mitochondrial membranes (ADP, NAD, citrate, pyrimidine nucleotides) and associated metabolic shuttles (malate-aspartate), plus a note on mitochondrial dynamics (membrane fission). Insulin/IGF signaling terms appear cosmetically, but the dominant theme is mitochondrial metabolite transport and exchange.","confidence":"High","size":9,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":3},{"id":"GO:0000066","count":3},{"id":"GO:0043490","count":3},{"id":"GO:0090149","count":3},{"id":"GO:0032869","count":3}]},{"hash":"531504232855043651","title":"Transmembrane solute transport","description":"Top GO terms show diverse transmembrane transport activities for sugars, vitamins, nitrate, potassium ions, and xenobiotics, plus osmotic stress response. The common theme is membrane transporter functions handling a variety of solutes, justifying a label around transmembrane solute transport.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":9},{"id":"GO:0035461","count":9},{"id":"GO:0006855","count":9},{"id":"GO:0071805","count":6},{"id":"GO:0071332","count":6}]},{"hash":"324540285887301473","title":"Skeletal ECM Remodeling and Signaling","description":"The cluster features terms tied to skeletal development, including cartilage condensation and bone remodeling, along with proteoglycan metabolism (heparan sulfate proteoglycans) and related ECM components, suggesting a focus on extracellular matrix remodeling in skeletal tissues. Additional terms point to membrane-associated processes (GPI anchor biosynthesis), endocytosis, and regulation of signaling pathways (EGFR) and angiogenesis, indicating coordinated cell-surface signaling that could modulate skeletal formation. Overall, the strongest theme centers on skeletal development and ECM interactions, with supporting membrane and signaling context.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0001502","count":1},{"id":"GO:0046849","count":1},{"id":"GO:0006506","count":1},{"id":"GO:0030202","count":1}]},{"hash":"45705274400225988","title":"Neuronal signaling and metabolic regulation","description":"The top terms highlight neuronal function (neurotransmitter secretion, memory) and metabolic control (insulin secretion in response to glucose). Supportive signals for calcium-mediated pathways (Wnt calcium modulating pathway) and stress responses (hypoxia, apoptosis) further point to signaling processes bridging neural and endocrine contexts. Some outliers (karyogamy, EMT) may reflect broader developmental signaling connections, but the core theme is neural communication paired with metabolic regulation. ","confidence":"Medium","size":9,"edges":21,"triangles":14,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":5},{"id":"GO:0043065","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0007613","count":5},{"id":"GO:0007269","count":5}]},{"hash":"730529414602056843","title":"Muscle Development and Cytoskeletal Remodeling","description":"The cluster is dominated by terms for skeletal muscle fiber development and adaptation, and mesenchyme migration, with actin cytoskeleton organization, pointing to muscle differentiation and cytoskeletal remodeling as the core theme. There are also hints of epigenetic and trafficking regulation (histone acetylation, regulation of endocytosis), but the strongest signal centers on muscle-related development and cytoskeletal dynamics.","confidence":"Medium","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0043983","count":7},{"id":"GO:0000147","count":7},{"id":"GO:0002121","count":7},{"id":"GO:0030100","count":7},{"id":"GO:0090131","count":7}]},{"hash":"535362785929827895","title":"Neural, Sensory, and Inflammatory Signaling","description":"Most terms cluster around neural/sensory biology (pain perception, temperature response, enteric nervous system development, locomotion) together with inflammatory signaling (IL-1\u03b2 regulation, prostaglandin response) and intracellular signaling (calcium release). This points to a neural-immune-sensory signaling theme, possibly involving gut-brain and metabolic regulation, rather than a single precise process.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0048484","count":4},{"id":"GO:0019076","count":4}]},{"hash":"115833549582023971","title":"Cerebellar Neural Development and Signaling","description":"The cluster is dominated by terms tied to cerebellar development (cerebellar cortex formation, Bergmann glial differentiation), neural connectivity (axon regeneration, dendritic spine development), and brain signaling (insulin/insulin receptor pathways), suggesting proteins involved in cerebellar neural development and associated signaling. An outlier term for T cell receptor signaling is present but does not overwhelm the neural/cerebellar theme.","confidence":"Medium","size":9,"edges":12,"triangles":3,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021697","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0008285","count":8},{"id":"GO:2001275","count":8},{"id":"GO:0048679","count":8}]},{"hash":"2195244385145633924","title":"Vertebrate embryonic and sensory organ development","description":"The top GO terms cluster around broad embryonic development and organogenesis across multiple tissues and sensory systems (brain, ear, eye, heart, placenta, limb, axis specification), plus associated functions like sensory perception and muscle proliferation. This points to a general theme of vertebrate development and sensory organ formation rather than a single specific pathway. ","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0007605","count":5},{"id":"GO:0007507","count":5}]},{"hash":"1021578332659414731","title":"Fungal proteostasis and ER stress","description":"The majority of top GO terms relate to unfolded protein response, chaperone-assisted refolding, and SRP-dependent targeting to the ER membrane, pointing to a proteostasis/secretory pathway cluster; additional terms for fungal cell wall synthesis and mating (beta-glucan biosynthesis, karyogamy) suggest a fungal context, but the core theme is protein folding and ER stress management.","confidence":"High","size":9,"edges":32,"triangles":60,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":6},{"id":"GO:1903382","count":6},{"id":"GO:0006880","count":6},{"id":"GO:0016226","count":6},{"id":"GO:0034620","count":6}]},{"hash":"998368252570601335","title":"Arabinogalactan protein\u2013related plant cell wall glycoproteins","description":"The cluster is driven by GO terms related to arabinogalactan protein metabolism, polysaccharide/glycoprotein biosynthesis (e.g., poly-N-acetyllactosamine, O-linked glycosylation) and plant-specific developmental processes like root hair and seed coat mucilage formation, together pointing to plant cell wall AGP glycoproteins involved in cell expansion and mucilage/root hair development.","confidence":"High","size":9,"edges":9,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046326","count":2},{"id":"GO:0030316","count":2},{"id":"GO:0075015","count":1},{"id":"GO:0042248","count":1},{"id":"GO:0030311","count":1}]},{"hash":"2266931659026485735","title":"Chloroplast gene expression and protein turnover","description":"This cluster combines GO terms related to DNA-templated transcription and DNA biosynthesis (gene expression) with photosynthesis-related activity (chloroplast energy production) and protein quality control/turnover (protein folding in ER, proteasome-related processes). The collection points toward chloroplast-associated processes involving gene expression and subsequent protein homeostasis, hence a label focusing on chloroplast gene expression and protein turnover.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0071897","count":2},{"id":"GO:0006810","count":1},{"id":"GO:0019684","count":1},{"id":"GO:0055114","count":1}]},{"hash":"1777081673654293073","title":"Ubiquitination and Viral Protein Processing","description":"The cluster shows strong representation of ubiquitin-dependent protein catabolic processes (including autoubiquitination and K48-linked ubiquitination), pointing to ubiquitin-proteasome\u2013related functions; coupling these with terms on viral protein processing and viral replication suggests a theme around host\u2013virus interactions and protein turnover.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032508","count":4},{"id":"GO:0090305","count":4},{"id":"GO:1901315","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0090263","count":4}]},{"hash":"628592992178417348","title":"NF-kappaB/TNF inflammatory signaling with autophagy","description":"These proteins show enrichment for NF-kappaB signaling and TNF-mediated pathways, along with autophagy, pointing to a cluster centered on inflammatory signaling and cellular stress responses. While other terms like miRNA metabolism and retinoic acid receptor signaling appear, the strongest signals are canonical NF-kappaB regulation and autophagy, suggesting a functional grouping around immune/inflammatory signaling and related regulatory processes.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043123","count":7},{"id":"GO:0006914","count":6},{"id":"GO:0010586","count":6},{"id":"GO:1901536","count":6},{"id":"GO:0001519","count":6}]},{"hash":"1513833407101163409","title":"Autophagy and Cellular Regulation","description":"The Top Terms include autophagy ( GO:0006914 ) as a central process, with many items pointing to regulation of various cellular pathways (e.g., ubiquitin-dependent proteolysis, miRNA metabolism, intracellular transport of viral material). The presence of developmental terms (stem cell proliferation, placenta morphogenesis) and signaling-related terms (brassinosteroid signaling, IL-17 signaling) suggests these proteins act as broad regulators across multiple pathways rather than a single, cohesive function. Taken together, the cluster appears to represent regulators of cellular processes with autophagy as a core component, hence the Autophagy and Cellular Regulation label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":9},{"id":"GO:1900458","count":9},{"id":"GO:0072089","count":9},{"id":"GO:2000059","count":9},{"id":"GO:0060669","count":9}]},{"hash":"1024914542941186193","title":"Innate immune cell activation and migration","description":"The top terms cluster around innate immune response, formation of immunological synapses, dendritic cell chemotaxis, and cytoskeletal structures (lamellipodium/microspike) involved in cell movement and cell-cell contact, suggesting a function in immune cell activation and migration. Some terms (e.g., positive regulation of viral entry) are less central and may be less informative, but the predominant theme is innate immune signaling together with actin-driven motility and synapse formation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0001771","count":2},{"id":"GO:0046598","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0060124","count":2}]},{"hash":"967480442483752339","title":"Axon guidance and cell adhesion in development","description":"This cluster centers on developmental signaling and neural connectivity, with multiple GO terms pointing to axon guidance (anterior/posterior guidance, Robo signaling) and cell-cell adhesion (homophilic/heterophilic). Additional terms relate to developmental processes (BMP signaling regulation, skeletal system and multicellular development) suggesting a broader developmental role that includes neural wiring and tissue organization.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030513","count":5},{"id":"GO:0046718","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0033564","count":4},{"id":"GO:0035385","count":4}]},{"hash":"1488714669354308875","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0061158","count":8},{"id":"GO:1902187","count":8},{"id":"GO:2000637","count":8},{"id":"GO:0007014","count":8},{"id":"GO:0006914","count":7}]},{"hash":"27605522275936599","title":"Unknown","description":"Top GO terms are highly heterogeneous, spanning transcription, methylation, metabolism, apoptosis/necroptosis, development, and immune responses across different organisms. There is no clear, cohesive function uniting these terms for this cluster, so a specific, representative label cannot be confidently assigned.","confidence":"","size":9,"edges":32,"triangles":58,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006479","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0042981","count":2},{"id":"GO:0042595","count":2}]},{"hash":"220950521883854734","title":"Immune Inflammation and Apoptotic Signaling","description":"Top GO terms point to immune and stress responses: inflammatory response and response to lipopolysaccharide, with signaling cascades such as JNK and extrinsic apoptotic pathway activation, and B cell apoptotic processes. There is also transcriptional regulation (positive regulation of miRNA transcription, gene expression) and an NF-kappaB-related term. This pattern suggests a module coordinating immune activation, inflammatory signaling, and programmed cell death, possibly in B cells or other immune cells, with ancillary links to transcriptional control. The angiogenesis-related term may reflect inflammation-associated vascular changes rather than a core pathway.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902895","count":3},{"id":"GO:1902043","count":2},{"id":"GO:0046330","count":2},{"id":"GO:0001783","count":2},{"id":"GO:0010467","count":2}]},{"hash":"1525969805718237638","title":"Embryonic Neurodevelopment and Ubiquitin-DNA Damage Response","description":"The cluster combines terms for in utero embryonic development and neuron projection development with ubiquitination pathways, ERAD, histone modification, and DNA damage response regulation. This suggests a cohesive role in early development where ubiquitin-mediated protein quality control and genome maintenance intersect with neuronal differentiation. Some terms are obsolete, but the core signal points to embryonic neural development tied to ubiquitin-dependent regulation of DNA repair and chromatin remodeling.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0001701","count":9},{"id":"GO:0085020","count":9},{"id":"GO:0010976","count":9},{"id":"GO:0070076","count":9},{"id":"GO:0030433","count":9}]},{"hash":"640422649666163305","title":"Unknown","description":"The top GO terms span animal processes (blood coagulation, cellular extravasation, endodermal differentiation, visual perception) and plant processes (chlorophyll biosynthesis, stamen formation), plus general topics like protein heterotrimerization and ubiquitin-dependent proteolysis, with no single coherent theme linking all terms. This suggests no clear shared function for the cluster, so an Unknown label is most appropriate.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0034113","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0007601","count":2}]},{"hash":"910377533906428163","title":"ECM Remodeling and Cell Adhesion","description":"The cluster\u2019s top GO terms converge on extracellular matrix regulation (negative regulation of ECM assembly, hyaluronan metabolism), integrin signaling, and various cell\u2013cell/cell\u2013matrix adhesion and migration processes (cellular extravasation, substrate-dependent migration, heterotypic adhesion). Coagulation and complement components appear but seem ancillary to the dominant theme of matrix organization and cell adhesion/migration, suggesting a functional cluster centered on ECM remodeling and cell interactions.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901202","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0006929","count":2},{"id":"GO:0006956","count":2}]},{"hash":"2000933383054770561","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006284","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0090305","count":2}]},{"hash":"1812866343849757113","title":"Cardiac development and stress-response signaling","description":"These proteins show prominent cardiac-associated terms such as Purkinje to ventricular signaling and positive regulation of cardiac muscle hypertrophy in response to stress, suggesting a cardiac development and stress-response theme. Other terms span broader development (multicellular organism development, skin and bone maturation) and environmental response (temperature, caffeine, pain perception), which may reflect ancillary roles or pleiotropy in a multi-tissue cluster. Overall, the strongest coherent signal is heart development and stress signaling, supporting the chosen label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0002024","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0043931","count":5}]},{"hash":"831404212551577237","title":"Axon guidance and synapse assembly","description":"The top GO terms are dominated by neural development functions, especially axon guidance and positive regulation of synapse assembly, with specific mentions of paranode localization and trigeminal nerve development, indicating a focus on neural connectivity and axon pathfinding. A few peripheral terms related to vascular or immune processes appear weaker and less representative of the core theme. Overall, the cluster appears to group proteins involved in neural connectivity and axon guidance.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007411","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0002175","count":4},{"id":"GO:0021740","count":4},{"id":"GO:0038033","count":4}]},{"hash":"538561456235502929","title":"Unknown","description":"The top GO terms span sensory perception, cardiac muscle relaxation, developmental processes, and xenobiotic metabolism with no single, coherent biological theme linking them, suggesting a heterogeneous set rather than a unified function. Therefore, a specific, high-confidence label cannot be assigned.","confidence":"","size":9,"edges":13,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055119","count":2},{"id":"GO:0007608","count":2},{"id":"GO:0035865","count":2},{"id":"GO:1900087","count":2},{"id":"GO:0033072","count":2}]},{"hash":"590860987773783714","title":"GPCR-Calcium Signaling in Cardiovascular Regulation","description":"The dominant GO terms point to GPCR-mediated signaling that activates adenylate cyclase, along with calcium release, prostaglandin responses, and cardiovascular processes such as blood pressure control, vascular smooth muscle differentiation, and coagulation. These features suggest a cluster focused on signaling networks that regulate heart and vessel function, with inflammation-related terms (IL-1\u03b2, prostaglandin response) reflecting cross-talk with immune pathways. While a couple of terms (electron transport chain, grooming behavior) may be less central, the core theme is GPCR-driven calcium signaling in cardiovascular contexts.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0045777","count":9},{"id":"GO:0032651","count":8},{"id":"GO:0051209","count":8}]},{"hash":"154854439435648576","title":"Neuronal adhesion and synaptic vesicle clustering","description":"The top terms point to neuronal cell\u2013cell adhesion and synaptic organization, including positive regulation of protein localization to the synapse and synaptic vesicle clustering, which together suggest a core function in synapse assembly/maintenance and vesicle organization. Supporting terms like cholesterol biosynthesis and oxidative detoxification may reflect membrane biology and cellular stress responses but do not override the central synaptic theme. Confidence: High","confidence":"","size":9,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007158","count":2},{"id":"GO:0098869","count":2},{"id":"GO:1902474","count":2},{"id":"GO:2000809","count":2},{"id":"GO:0050783","count":1}]},{"hash":"271206660441223249","title":"Negative regulation of immune and receptor signaling","description":"This cluster centers on downregulation of signaling pathways at the cell surface, including IL-2, TLR9, and PDGF receptor signaling, as well as regulation of protein tyrosine kinase activity and integrin-mediated adhesion. Additional terms point to vascular permeability control and receptor turnover, supporting a theme of modulating receptor signaling rather than promoting activation. A couple of outliers (vestibular morphogenesis, muramyl dipeptide response) exist but do not override the core pattern.","confidence":"Medium","size":9,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043116","count":5},{"id":"GO:0034394","count":5},{"id":"GO:0061097","count":5},{"id":"GO:1902206","count":4},{"id":"GO:2000646","count":4}]},{"hash":"1982661503410066769","title":"Neuronal signaling and sensory development","description":"The cluster shows key neural activity features: ion transport (potassium, calcium) underlying excitability and signaling, excitatory postsynaptic potentials, and monoamine pathways (serotonin signaling, dopamine secretion). The inclusion of circadian sleep regulation and heart rate modulation via autonomic pathways, plus development terms for the lateral geniculate nucleus and vestibulocochlear nerve, points to both neuronal communication and sensory pathway development.","confidence":"High","size":9,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":8},{"id":"GO:0045188","count":6},{"id":"GO:0098703","count":6},{"id":"GO:0001964","count":6},{"id":"GO:0060079","count":6}]},{"hash":"124260962115341180","title":"Axon Guidance and Neural Crest Migration","description":"GO terms indicate a cohesive focus on neural development, especially axon pathfinding (sympathetic and branchiomotor neuron guidance, axonal extension, fasciculation) and neural crest cell migration, with semaphorin-plexin signaling as a key mechanism. Additional terms on trigeminal nerve organization and related junctions support this theme, while vessel branching and basement membrane references are secondary context; overall the cluster centers on neuronal wiring and formation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021637","count":3},{"id":"GO:0097491","count":3},{"id":"GO:0097490","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0036486","count":3}]},{"hash":"2261460728936439686","title":"Membrane transporters for sugars and nutrients","description":"The dominant GO terms describe transmembrane transport of diverse solutes (glucose, galactose, trehalose, nitrate, potassium ions, vitamins/xenobiotics) and related osmotic/fructose responses, indicating a cluster of membrane transport proteins mediating solute uptake and osmotic balance.","confidence":"High","size":9,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":8},{"id":"GO:0035461","count":8},{"id":"GO:0006855","count":8},{"id":"GO:0071805","count":6},{"id":"GO:0071332","count":6}]},{"hash":"666603256279270978","title":"Vascular development and coagulation","description":"The cluster shows a strong enrichment for angiogenesis and endothelial migration terms (GO:0045894, GO:0043536, GO:0045907) along with coagulation-related terms (GO:0072378, GO:0072377), pointing to functions in blood vessel formation, vascular regulation, and clotting. Other terms like protein localization to the cell surface and pattern recognition signaling may reflect ancillary endothelial or immune-sensing roles but do not redefine the main vascular/coagulation theme. Confidence: Medium","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072378","count":4},{"id":"GO:0034394","count":3},{"id":"GO:0006517","count":3},{"id":"GO:0006397","count":2},{"id":"GO:0045766","count":2}]},{"hash":"43758529428154134","title":"Angiogenesis Regulation and Vascular Remodeling","description":"The cluster is driven by GO terms that center on blood vessel formation and its regulation (both negative and positive angiogenesis), endothelial cell migration, and ECM organization, with supplementary signals related to coagulation and inflammatory vascular signaling, indicating a cohesive theme of vascular development and remodeling.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0045766","count":3},{"id":"GO:0002752","count":3},{"id":"GO:0001525","count":3}]},{"hash":"1282099416896810573","title":"Plant Strigolactone Response and Shoot Formation","description":"GO terms point to plant-specific signaling and development (cellular response to strigolactone; secondary shoot formation) with additional metabolic biosynthesis/catabolism processes, suggesting a cluster centered on growth regulation linked to strigolactone pathways plus broader metabolism. Confidence reflects partial but not definitive functional linkage.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042952","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0009102","count":1},{"id":"GO:1902348","count":1},{"id":"GO:0006212","count":1}]},{"hash":"1343679751148529724","title":"Developmental differentiation and apoptosis signals","description":"Top GO terms indicate development- and differentiation-related processes (central nervous system morphogenesis, endodermal differentiation, brown fat cell differentiation, epithelial integrity) with occasional links to apoptosis (extrinsic apoptotic signaling, mitochondrial fragmentation) and metabolic regulation (glucose import). This mix points to a broad developmental/differentiation program with ancillary survival/metabolic facets, rather than a single, tightly defined pathway. Confidence is limited due to heterogeneity and lack of shared direct function.","confidence":"Low","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021551","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0045715","count":2},{"id":"GO:0035160","count":2},{"id":"GO:0035987","count":2}]},{"hash":"750191346260050913","title":"Biosynthesis and protein acetylation","description":"The top GO terms point to multiple biosynthetic pathways (mycothiol, arginine, glucosamine, melatonin) alongside several acetylation-related processes (peptidyl-lysine N6-acetylation, N-terminal acetylation, histone acetylation). This suggests a shared focus on biosynthetic activity and protein modification via acetylation, despite some obsolete terms that reduce coherence. ","confidence":"Medium","size":9,"edges":21,"triangles":17,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":9},{"id":"GO:0001525","count":9},{"id":"GO:0060358","count":9},{"id":"GO:0017198","count":9},{"id":"GO:0006041","count":9}]},{"hash":"399453917675157418","title":"Fat cell differentiation and lipid metabolism","description":"The strongest signal is fat cell differentiation (3 hits), supported by adjacent lipid-related terms such as glycerophospholipid catabolic process and calcium signaling that can intersect adipocyte biology and lipid handling. While other terms touch on immune regulation and protein modification, the dominant theme centers on adipogenesis and lipid metabolism, justifying this label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":3},{"id":"GO:0051209","count":2},{"id":"GO:0046475","count":2},{"id":"GO:0035508","count":2},{"id":"GO:0070212","count":2}]},{"hash":"2210074822109649630","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":6},{"id":"GO:0007014","count":6},{"id":"GO:2000637","count":6},{"id":"GO:0061158","count":6},{"id":"GO:0006914","count":5}]},{"hash":"604885408725567838","title":"Membrane repair and innate immune autophagy","description":"This cluster centers on plasma membrane repair, innate immune response, and autophagy (with related signaling like Rho and NF-kappaB), suggesting a theme of cellular membrane damage response and autophagic innate immunity. While a couple of terms relate to development or plant signaling and may be annotation noise, the core terms consistently point to membrane-associated stress responses and immune/autophagic processes.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001778","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1661231180443726767","title":"Neural development and axon guidance","description":"The strongest terms are axonal fasciculation and axon extension involved in axon guidance, which strongly indicate neural development and connectivity formation. Embryonic development and behavior-related terms also support a neural-development theme, while a few immune/defense terms appear as potential noise or cross-annotation. Overall, the cluster appears best described by neural development and axon guidance, with some discordant terms. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0048846","count":3},{"id":"GO:0045766","count":2},{"id":"GO:0002357","count":2},{"id":"GO:0001701","count":2}]},{"hash":"2264108072574227407","title":"Immune signaling and inflammatory responses","description":"The GO terms point to a core theme of immune/inflammatory signaling: cellular response to lipopolysaccharide, TNF-mediated signaling, NF-kappaB regulation, and interferon-beta response, plus an apoptosis pathway linked to p53. This suggests proteins in the cluster collectively participate in immune stress and inflammatory signaling. A few terms (endosome transport, bone mineralization, symbiont invasion suppression) are more peripheral or reflect broader signaling roles, but they do not override the dominant immune/inflammatory theme.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0034051","count":3},{"id":"GO:0042771","count":3},{"id":"GO:0042347","count":3},{"id":"GO:0033209","count":3}]},{"hash":"478814209478386474","title":"Embryonic skeletal and cardiovascular development","description":"The top GO terms cluster around embryonic formation of the skeletal system (cranial skeleton morphogenesis, skeletal system development) and cardiovascular development (heart development, angiogenesis), with supporting developmental signaling (ERK, PI3K pathways). This suggests proteins function together in embryonic skeletal and heart/vascular development, justifying the label. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0010800","count":3},{"id":"GO:0031663","count":3}]},{"hash":"789092602621172189","title":"Membrane transport of sugars and ions","description":"This cluster is defined by transmembrane transport terms for multiple substrates (glucose, galactose, fructose, trehalose, nitrate/nitrite, potassium) and includes an osmotic stress response term, pointing to a coordinated set of transporters involved in nutrient uptake and osmotic adaptation. The shared theme across GO terms is substrate transport across the membrane, spanning sugars and inorganic ions. Overall, this label best captures the central function of the cluster.","confidence":"High","size":8,"edges":11,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":1},{"id":"GO:0071332","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0015757","count":1},{"id":"GO:0015706","count":1}]},{"hash":"815797322112582761","title":"Diverse solute transporters","description":"This cluster is dominated by transmembrane transport GO terms for a wide range of substrates (ions like K+, Na+; sugars such as galactose and arabinose; nitrate/nitrite; sialic acid; vitamins; and other solutes). The shared function appears to be broad solute transport across membranes rather than a single substrate class, suggesting a group of diverse membrane transport proteins. ","confidence":"High","size":8,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0015751","count":3}]},{"hash":"85544781802559716","title":"RNA processing and translation initiation","description":"The cluster centers on RNA maturation and export processes (small-subunit processome, mRNA polyadenylation/export) and the assembly of translation initiation machinery (eIF4F complex) and related initiation pathways, suggesting a functional grouping around RNA processing coupled to initiation of translation.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0034462","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0097010","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0006406","count":2}]},{"hash":"1682446332864139852","title":"Cardiac GPCR\u2013cAMP Signaling and Inflammation","description":"The cluster is enriched for GPCR signaling terms that activate adenylate cyclase and cAMP ( adrenergic and dopamine pathways ), plus related heart development, prostaglandin response, inflammatory response, and even blood coagulation. This suggests a cohesive theme of GPCR-mediated signaling in cardiovascular contexts with inflammatory involvement; phototransduction and PI biosynthesis terms may reflect broader GPCR/regulatory networks. Therefore a label focusing on cardiac GPCR\u2013cAMP signaling, with an inflammatory component, best captures the shared function.","confidence":"Medium","size":8,"edges":16,"triangles":10,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0007603","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0045745","count":3}]},{"hash":"1478349487116288362","title":"Unknown","description":"The top terms span translation, inflammatory signaling, calcium signaling, prostaglandin response, coagulation, vascular differentiation, and even behavior/vision-related processes, which are too heterogeneous to define a single cohesive function. This lack of a clear shared theme makes it difficult to assign a precise, representative label with confidence.","confidence":"","size":8,"edges":16,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0032651","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0007596","count":2}]},{"hash":"1529841982691581530","title":"Ribosome Biogenesis and Translational Regulation","description":"The cluster is dominated by GO terms for ribosome biogenesis and translation, with related mentions of translational fidelity maintenance, indicating proteins involved in ribosome assembly and control of protein synthesis; a few other terms (e.g., stress signaling and cell cycle-related processes) appear but do not overshadow the core theme.","confidence":"High","size":8,"edges":25,"triangles":40,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0046330","count":2},{"id":"GO:0045903","count":1},{"id":"GO:0046677","count":1}]},{"hash":"82768262383769509","title":"Unknown","description":"The GO terms span neuronal localization to paranodes, sensory nucleus development, VEGF signaling affecting endothelial chemotaxis, and several immune regulatory processes (NK cell, mast cell, TLR9 signaling, NF-kB). The diversity and inclusion of obsolete terms indicate no single cohesive function tying all proteins together, suggesting a heterogeneous set rather than a distinct pathway.","confidence":"","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":2},{"id":"GO:0021740","count":2},{"id":"GO:0038033","count":2},{"id":"GO:1904604","count":2},{"id":"GO:0002859","count":2}]},{"hash":"182868368628276840","title":"Cytoskeleton remodeling and cell migration","description":"The GO terms cluster around fibroblast migration, filopodium assembly, membrane addition during cytokinesis, and Rap signaling, suggesting a shared theme of cytoskeletal dynamics and membrane remodeling driving cell movement and division.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010762","count":1},{"id":"GO:0031584","count":1},{"id":"GO:0035564","count":1},{"id":"GO:0051291","count":1},{"id":"GO:0010514","count":1}]},{"hash":"1709937183861504485","title":"Negative Regulation of Signaling Pathways","description":"The GO terms cluster around downregulation of signaling activities across immune and inflammatory pathways, including regulation of protein tyrosine kinase activity, TLR signaling, p38 MAPK cascade, PDGFR signaling, and integrin-mediated adhesion. While a couple terms touch on vestibular morphogenesis or receptor responses, the dominant theme is inhibition of signaling processes, suggesting proteins that dampen signaling rather than activate it. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043116","count":3},{"id":"GO:0061097","count":3},{"id":"GO:1902206","count":2},{"id":"GO:2000646","count":2},{"id":"GO:0060116","count":2}]},{"hash":"551414044057914386","title":"Negative regulation of immune signaling","description":"The GO terms co-occurring in this cluster predominantly describe inhibitory or dampening roles in immune-related pathways (e.g., negative regulation of IL-2 signaling, TLR9 signaling, p38MAPK cascade, and integrin-mediated adhesion), along with responses to muramyl dipeptide and modulation of granzyme B production, pointing to a theme of immunoregulation and immune signaling attenuation. A non-immune term (vestibular receptor morphogenesis) likely represents noise. Overall, the cluster appears to group proteins involved in downregulating immune signaling pathways.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902206","count":6},{"id":"GO:2000646","count":6},{"id":"GO:0060116","count":6},{"id":"GO:0071225","count":6},{"id":"GO:0033629","count":6}]},{"hash":"1176842788130029426","title":"Developmental and Lipid Regulation","description":"The terms point to broad developmental processes across multiple organs (eye, heart valve, loop of Henle, embryo) and lipid-related activities (fat cell differentiation, LDL response, ganglioside metabolism), with some vascular regulation (fibrinogen). This suggests a cluster of proteins involved in general development with supporting metabolic regulation rather than a single pathway.","confidence":"Medium","size":8,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0043010","count":2},{"id":"GO:0003180","count":2},{"id":"GO:0001573","count":2},{"id":"GO:0045598","count":2}]},{"hash":"698828748714378782","title":"Proteasome-Mediated Protein Degradation and Quality Control","description":"The cluster is dominated by GO terms related to the ubiquitin-proteasome system and ER-associated degradation, such as positive regulation of proteasomal protein catabolic process and proteasome regulatory particle assembly, indicating a cohesive role in protein quality control and turnover; other terms appear more peripheral.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:2001171","count":2},{"id":"GO:0071712","count":2},{"id":"GO:1901800","count":2},{"id":"GO:0070682","count":2},{"id":"GO:0030433","count":2}]},{"hash":"880636256780687153","title":"Viral Entry and Genome Integration","description":"The top GO terms point to virus/symbiont entry into host cells and integrated proviral latency, including DNA integration, suggesting a virus\u2013host interaction and genome integration theme; the surrounding cell wall and glycosylation terms are less representative and could reflect incidental annotations.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0030244","count":1},{"id":"GO:0036108","count":1}]},{"hash":"70715361750154284","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":16,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":3},{"id":"GO:0035455","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000266","count":2}]},{"hash":"2198446573478016132","title":"Transmembrane Solute Transport","description":"The terms center on transport of multiple solutes across membranes (K+, sugars, nitrates/nitrite, trehalose, etc.) and an osmotic stress response, indicating a cluster of membrane transport proteins involved in solute uptake and osmoregulation.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0071332","count":5},{"id":"GO:1904659","count":5},{"id":"GO:0015757","count":5},{"id":"GO:0015706","count":5}]},{"hash":"2046878560440795635","title":"Golgi vesicle trafficking and SNARE assembly","description":"The terms cluster around Golgi apparatus\u2013focused vesicle transport (ER-to-Golgi, intra-Golgi, vesicle fusion with Golgi) and SNARE complex assembly, indicating a cohesive module of proteins driven by SNARE-mediated Golgi trafficking; occasional links to synaptic potentiation and insulin signaling appear peripheral.","confidence":"High","size":8,"edges":10,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":4},{"id":"GO:0090316","count":4},{"id":"GO:0042147","count":4},{"id":"GO:0035493","count":4},{"id":"GO:0060291","count":4}]},{"hash":"1786492952359303013","title":"Mitotic progression and ubiquitin-mediated degradation","description":"The dominant GO terms are about mitosis and cell-cycle transitions (exit from mitosis, chromosome segregation, G2/M transition). Several terms highlight ubiquitin-proteasome\u2013mediated proteolysis (SCF-dependent, K6-linked ubiquitination), which is key for timely mitotic protein turnover. Additional terms for DNA repair and embryonic development appear but are less central, suggesting the core function is mitotic regulation via ubiquitin-mediated degradation, with some pleiotropic associations.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0010458","count":8},{"id":"GO:0031146","count":8},{"id":"GO:0007059","count":8},{"id":"GO:0016032","count":8},{"id":"GO:0070911","count":8}]},{"hash":"1009089233879490933","title":"Fungal proteostasis and secretory pathway","description":"Clustering terms point to protein homeostasis and targeting to the secretory pathway in fungal cells, with emphasis on unfolded protein response and ER stress\u2013regulated apoptotic signaling, chaperone-assisted folding, and SRP-dependent targeting to membranes. Some terms hint at fungal-specific processes like beta-glucan biosynthesis and karyogamy, but the dominant theme is proteostasis and protein trafficking rather than a single metabolic process.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":6},{"id":"GO:0090084","count":5},{"id":"GO:1903382","count":5},{"id":"GO:0006880","count":5},{"id":"GO:0016226","count":5}]},{"hash":"9587332708702520","title":"Endothelial Morphogenesis and Signaling","description":"These proteins cluster around endothelial and heart development signals: coronary vasculature development, regulation of VEGF and HGF signaling, endothelial tube morphogenesis, and heart trabecula formation. The GO terms also include BMP and TNF-related responses, suggesting coordination of vascular growth and tissue morphogenesis. Overall, the dominant theme is endothelial morphogenesis and vascular signaling in cardiovascular development.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060976","count":1},{"id":"GO:0071356","count":1},{"id":"GO:1900748","count":1},{"id":"GO:1901509","count":1},{"id":"GO:1902548","count":1}]},{"hash":"1526484544962371148","title":"Ubiquitin-mediated proteolysis under stress","description":"This cluster is dominated by GO terms for ubiquitination and proteasomal degradation (SCF-dependent ubiquitin-protein catabolic process, protein polyubiquitination, positive regulation of polyubiquitination) and includes stress-response terms (cellular response to methylmercury, cadmium ion, oxidative stress-induced apoptotic signaling). While there are some cell cycle/DNA replication-related terms, the ubiquitin-proteasome axis and stress responsiveness best explain the cluster\u2019s shared function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071406","count":2},{"id":"GO:1903378","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0042752","count":2},{"id":"GO:0031571","count":2}]},{"hash":"1630226731638661727","title":"Plant amino acid biosynthesis and defense","description":"This cluster is driven by several amino acid biosynthesis terms (lysine, tyrosine, phenylalanine) and biotin biosynthesis, alongside lipid metabolism and plant-specific responses such as systemic acquired resistance and fruit ripening. The combination suggests a cohesive theme of plant metabolism linked to defense and developmental signaling, rather than a single narrowly defined pathway.","confidence":"Medium","size":8,"edges":25,"triangles":40,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":4},{"id":"GO:0055089","count":3},{"id":"GO:0006571","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0009102","count":3}]},{"hash":"1324449509151168020","title":"Metabolic Biosynthesis and Nutrient Response","description":"This cluster includes multiple metabolic and biosynthetic processes (biotin biosynthesis, protoporphyrinogen IX biosynthesis) along with catabolic pathways (L-alanine, L-kynurenine) and metal/cofactor related functions (iron incorporation into metallo-sulfur clusters, vitamin B6), plus regulatory responses (cAMP, antibiotic). The Notch signaling term is likely an outlier or annotation noise; overall the group centers on metabolism and cofactor biology with some stress/regulatory links. Therefore, Metabolic Biosynthesis and Nutrient Response seems representative, with Medium confidence.","confidence":"Medium","size":8,"edges":23,"triangles":32,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0097053","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0042853","count":3}]},{"hash":"2257321073839615174","title":"Unknown","description":"Top terms are largely disparate, with several pointing to DNA mobility and proviral integration (DNA transposition, DNA integration, integrated proviral latency) but others describe unrelated processes (cell division, immunoglobulin production in mucosal tissue, intestinal absorption, behavior). There is no single coherent function linking all proteins in this cluster, so Unknown with no confidence is appropriate.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":1},{"id":"GO:0007059","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0046718","count":1}]},{"hash":"846398534210541756","title":"Autophagy and ubiquitin-mediated signaling","description":"The cluster is centered on autophagy with strong links to ubiquitin-mediated regulation (K6-linked ubiquitination, ERAD, deubiquitination). This points to a shared role in cellular quality control and modulation of inflammatory signaling (NF-kappaB, TNF) and membrane repair, despite several older/obsolete annotations.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":3},{"id":"GO:1901536","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0051092","count":3}]},{"hash":"1590758558293963579","title":"Ubiquitin-Dependent Protein Turnover and Signaling","description":"This cluster shows a strong theme of ubiquitin-mediated protein degradation and regulation (ubiquitin-dependent protein catabolic process, autoubiquitination, and K48-linked ubiquitination), suggesting proteasome-driven turnover. Related terms for apoptosis regulation, integrin signaling, hypoxia response, and developmental and metabolic processes indicate broader regulatory roles tied to protein stability and signaling, rather than a single pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043065","count":3},{"id":"GO:0045071","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0051865","count":3}]},{"hash":"2178592347141146798","title":"Neuronal proteostasis and amyloid clearance","description":"The top terms converge on ubiquitin-dependent protein catabolic processes, ERAD-related degradation, lysosome targeting, and amyloid-beta clearance, all pointing to neuronal protein quality control and clearance of protein aggregates; neural development terms further support a neural context.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:2000060","count":6},{"id":"GO:0007568","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0010867","count":4}]},{"hash":"219691139709307462","title":"Tagatose-6-phosphate/Lactose Catabolism","description":"The GO terms are dominated by sugar catabolic processes, especially D-tagatose-6-phosphate catabolism and lactose catabolic via tagatose-6-phosphate, implying these proteins participate in tagatose-6-phosphate\u2013dependent carbohydrate breakdown. Some unrelated terms appear (e.g., spindle attachment, obsolete terms), likely annotation noise, but the core signal points to tagatose/lactose metabolism.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042997","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0019433","count":2},{"id":"GO:2001059","count":2},{"id":"GO:1902777","count":2}]},{"hash":"999749542789817259","title":"Retina phototransduction and eye development","description":"The top terms include phototransduction and retina development in a camera-type eye, plus dopaminergic regulation of synaptic transmission, pointing to a retina/eye-focused functional cluster. While there are broader terms (ERK signaling, metabolic regulation), the strongest signals are tied to retinal function and eye development.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032226","count":2},{"id":"GO:0035774","count":1},{"id":"GO:0007602","count":1},{"id":"GO:1900136","count":1},{"id":"GO:0044252","count":1}]},{"hash":"634464301896320850","title":"Neural signaling and neurotransmission","description":"The terms converge on neuronal communication: serotonin and dopamine-related signaling, cholinergic synaptic transmission, membrane depolarization, and potassium-driven excitability, plus autonomic heart-rate regulation. Developmental terms for LGN and vestibulocochlear nerve suggest neural structure formation. Together, they reflect a cohesive theme of neural signaling, synaptic activity, and neuronal development.","confidence":"High","size":8,"edges":16,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0033603","count":7},{"id":"GO:0001988","count":7},{"id":"GO:0021771","count":7}]},{"hash":"1739174358456047504","title":"Steroid hormone and lipid biosynthesis","description":"The GO terms are dominated by steroid hormone biosynthesis and metabolism (estrogen, testosterone, glucocorticoids, androgens) with supporting lipid biosynthesis terms (very long-chain fatty acids, sphingolipids) and related redox processes. This suggests the cluster groups proteins involved in steroid hormone production and associated lipid pathways.","confidence":"High","size":8,"edges":18,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008207","count":2},{"id":"GO:0006703","count":2},{"id":"GO:0042761","count":2},{"id":"GO:0006710","count":2},{"id":"GO:0061370","count":2}]},{"hash":"1686869251020838469","title":"Protein acetylation enzymes","description":"The GO terms are dominated by acetylation-related processes (histone H4 acetylation, peptidyl-lysine N6-acetylation, N-terminal peptidyl-glutamic acid acetylation), suggesting enzymes that add acetyl groups. While there are some biosynthetic terms (mycothiol, arginine, melatonin, glucosamine), the acetylation annotations provide the most coherent shared function for this cluster, indicating a focus on acetyltransferase activity rather than a single, unified biosynthetic pathway.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":8},{"id":"GO:0001525","count":8},{"id":"GO:0060358","count":8},{"id":"GO:0017198","count":8},{"id":"GO:0006041","count":8}]},{"hash":"276975116073693159","title":"Mitotic Division and ER-Golgi Trafficking in Development","description":"This cluster centers on mitosis-related terms (cell division, mitotic cell cycle, mitotic spindle assembly) and vesicle trafficking between ER and Golgi (COPII budding and retrograde transport), with brain development and multicellular growth indicating a developmental context.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0090114","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0035264","count":3}]},{"hash":"313746916519172024","title":"Beta-lactamase regulation and antibiotic degradation","description":"The top GO terms are centered on antibiotic-related functions, especially response to antibiotic, regulation of beta-lactamase activity, and beta-lactam antibiotic catabolic (degradative) processes, suggesting the cluster is linked to antibiotic resistance or processing. Some terms appear as unrelated noise (e.g., autophagy targeting to vacuole, nylon catabolic, histone methylation), but the core theme around beta-lactamase and antibiotic degradation points to a coherent functional group.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0070814","count":2},{"id":"GO:0019876","count":1},{"id":"GO:0033252","count":1}]},{"hash":"1880479994305814291","title":"Neuronal signaling and autonomic regulation","description":"The top GO terms point to neurotransmission and neuromodulation (serotonin signaling, dopamine secretion, cholinergic transmission, membrane depolarization) together with behavioral outputs (locomotory behavior) and autonomic control (heart rate regulation). The presence of development terms for brain structures (lateral geniculate nucleus, vestibulocochlear nerve) further supports a CNS-focused, synaptic signaling cluster. Overall, these proteins appear to function in neural signaling pathways that influence behavior and autonomic responses.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":6},{"id":"GO:0007210","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0033603","count":4},{"id":"GO:0001988","count":4}]},{"hash":"1724086151404000371","title":"Neural Development and Signaling","description":"The top GO terms cluster around nervous system development and function (axon guidance, cerebellar Purkinje cell layer development, motor learning) and include embryonic development with signaling pathways (BMP, VEGF, HGF receptor signaling, nitric oxide). This suggests proteins linked to developmental processes, particularly neural development, rather than a single specific pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048843","count":1},{"id":"GO:0001701","count":1},{"id":"GO:1902548","count":1},{"id":"GO:0061743","count":1},{"id":"GO:0071773","count":1}]},{"hash":"1680554116323122129","title":"Ribosome Biogenesis and ER Protein Quality Control","description":"This cluster centers on translation and ribosome assembly, with strong signals for ER stress responses and protein quality control, including unfolded protein response and proteasomal degradation, plus related trafficking. The presence of these GO terms suggests a coherent theme around coordinating protein synthesis with ER-associated quality control and degradation pathways, rather than a single viral or vesicle-specific function. Confidence: Medium","confidence":"","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000027","count":3},{"id":"GO:0019079","count":3},{"id":"GO:2001171","count":2},{"id":"GO:0071712","count":2}]},{"hash":"359640441595284296","title":"Gametogenesis and DNA replication regulation","description":"The cluster\u2019s top GO terms cluster around germ cell development (karyogamy, spermatogenesis, spermatid development) while also highlighting DNA replication and transcription/splicing processes, suggesting proteins that function in reproductive cell maturation with coordinated regulation of transcription and genome replication.","confidence":"Medium","size":7,"edges":16,"triangles":16,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0006260","count":2},{"id":"GO:1903026","count":1}]},{"hash":"1538461302063944378","title":"Lymphocyte Activation and Antibody Differentiation","description":"The terms cluster around immune cell regulation, especially B and T cell activity: B cell differentiation and IgG isotype switching, cytokine production, and positive signaling (JNK cascade) accompany T cell activation and activation-induced cell death; immunological synapse formation and immune signaling are prominent, with some development-related terms included. This suggests a cohesive theme of lymphocyte activation, differentiation, and regulation of immune responses. Hedgehog-related and neuromuscular terms are less central but present as supporting signals in broader developmental contexts. Confidence: High.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:2001241","count":3},{"id":"GO:0006924","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0045880","count":3}]},{"hash":"1056635714199631470","title":"Unknown","description":"The listed GO terms span many unrelated processes (actin nucleation regulation, fertilization, ribosomal RNA maturation, chromatin modification, cell fusion, immune defense, hypoxia, TGF-beta signaling, and ERAD), with no common pathway uniting them and no edges connecting the proteins, so a cohesive label cannot be assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034316","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0060770","count":2},{"id":"GO:0051568","count":2}]},{"hash":"1705429972862676682","title":"Proteostasis and ER stress response","description":"The enriched GO terms center on unfolded protein response, ER stress, and SRP-dependent cotranslational targeting to membranes, pointing to a shared role in protein folding and trafficking through the secretory pathway. Oxidative stress and apoptotic signaling terms further support a cellular stress/quality-control theme, with some yeast-specific processes appearing incidental rather than core to the cluster\u2019s function.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":5},{"id":"GO:1903382","count":5},{"id":"GO:0006880","count":5},{"id":"GO:0016226","count":5},{"id":"GO:0034620","count":5}]},{"hash":"461976751212134958","title":"Developmental Transcriptional Regulation and Signaling","description":"This set includes GO terms centered on DNA-templated transcription and transcription factor activity regulation, as well as multiple development-related processes (Wnt signaling, sclerotome, pancreatic, prostate morphogenesis, and skeletal muscle satellite cell maintenance). The common thread appears to be proteins involved in controlling gene expression during development and associated signaling pathways, despite the diverse tissue contexts. Confidence: Medium.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043433","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0014834","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006313","count":1}]},{"hash":"306572370984749924","title":"Embryonic development and cell junctions","description":"The cluster is dominated by developmental processes (root and neural plate development, dorsal identity, oocyte localization) and by cell\u2013cell adhesion/junction assembly (desmosomes, adherens junctions) plus cytoskeletal localization. This points to proteins coordinating tissue morphogenesis and cell junction formation during development.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":5},{"id":"GO:0001840","count":5},{"id":"GO:0080034","count":5},{"id":"GO:0086073","count":5},{"id":"GO:0072699","count":5}]},{"hash":"2230974749259277915","title":"Vertebrate Developmental and Transcriptional Regulation","description":"The cluster is enriched in vertebrate developmental terms (in utero embryonic development, pituitary gland development, retina development, osteoblast development) and transcription regulation by RNA polymerase II, with supporting signals related to cAMP signaling and metabolic processes. This suggests a coherent theme of developmental differentiation accompanied by transcriptional control, rather than a single metabolic pathway. Therefore, a label focusing on vertebrate development and transcriptional regulation is appropriate.","confidence":"Medium","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006366","count":2}]},{"hash":"711771081038815598","title":"Axon guidance and neural development","description":"The dominant GO terms cluster around neural development and axon pathfinding\u2014Smoothened and Roundabout signaling, axon guidance, and paranode localization\u2014indicating roles in nervous system development and neural circuit formation. ERK cascade regulation also aligns with signaling during development. A few outliers (kidney development, myoblast differentiation, T cell signaling) appear less central but do not override the neural-focused theme. Confidence: High","confidence":"","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0050852","count":3}]},{"hash":"195425523375471532","title":"Dopaminergic signaling and synaptic plasticity","description":"The top terms cluster around dopamine-related synaptic transmission, learning, and reward-related behaviors (visual learning, cocaine response), with ERK/MAPK signaling and phosphorylation as key plasticity mechanisms, suggesting a brain-centric theme of dopamine-mediated neural plasticity, despite a few outlier terms like heart development and macrophage chemotaxis.","confidence":"Medium","size":7,"edges":14,"triangles":10,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":5},{"id":"GO:0008542","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0010759","count":5},{"id":"GO:0006468","count":5}]},{"hash":"1011041265159492958","title":"Neurodevelopment and Pigmentation","description":"The cluster shows GO terms tied to neural development (positive regulation of neuroblast proliferation; ventricular zone neuroblast division) alongside pigmentation-related processes (melanin biosynthetic process from tyrosine; melanin biosynthetic process; pigmentation; melanosome organization). These two themes suggest a broader developmental context rather than a single enzymatic function, spanning neural proliferation/division and pigment production in developmentally active organisms. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002052","count":2},{"id":"GO:0018996","count":1},{"id":"GO:0043050","count":1},{"id":"GO:0048023","count":1},{"id":"GO:0021847","count":1}]},{"hash":"1963173762486880150","title":"Calcium-Regulated Signaling in Differentiation and Muscle","description":"The cluster highlights calcium-related signaling: negative regulation of calcium import, calcium channel activity, the Wnt/calcium pathway, and terms tied to muscle contraction (diaphragm contraction) and secretion (insulin release). EMT and other differentiation-related terms suggest a role in development, all linked by calcium-dependent signaling. This combination supports a label centered on calcium-regulated signaling governing differentiation and muscle-associated processes, though the diversity reduces the certainty to a Medium level.","confidence":"Medium","size":7,"edges":15,"triangles":20,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":5},{"id":"GO:0000742","count":5},{"id":"GO:0001837","count":4},{"id":"GO:0007223","count":4},{"id":"GO:0035774","count":4}]},{"hash":"1872075653082333097","title":"Muscle and adipose cell signaling","description":"The top GO terms center on muscle-related processes (calcium release into cytosol, response to muscle stretch, and regulation linked to muscle contraction), adipogenesis (fat cell differentiation), and lipid turnover (glycerophospholipid catabolism), with additional signals in general cellular signaling and protein turnover (poly-ADP-ribosylation, pinocytosis, proteasome assembly). Together they suggest a theme of signaling and differentiation in muscle and fat cells, with supporting roles for lipid metabolism and protein homeostasis. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0051209","count":2},{"id":"GO:0046475","count":2},{"id":"GO:0035508","count":2},{"id":"GO:0070212","count":2}]},{"hash":"979399280729855906","title":"Neural development and synaptic connectivity","description":"The top GO terms cluster around nervous system development, positive regulation of synapse assembly, and glutamatergic synaptic transmission, with supporting roles for cell adhesion and axonal fasciculation. These collectively point to proteins shaping neural wiring and synapse formation, including sensory structures like the inner ear and neurovascular signaling contexts; a few immune-related terms are present but do not outweigh the neural signal.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0035249","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0007157","count":2}]},{"hash":"664647386390489250","title":"Neural and Cardiac Development","description":"The cluster\u2019s top GO terms cluster around nervous system formation (axonogenesis, Schwann cell development, excitatory synaptic activity) alongside cardiovascular development (heart development, angiogenesis). This points to a shared theme of developmental programs governing neural and heart/vascular maturation, with some proliferation-related terms likely reflecting growth processes during development; a plant signaling term appears incidental. Overall, the proteins seem tied to neural and cardiovascular development and maturation.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":6},{"id":"GO:0009738","count":6},{"id":"GO:0000086","count":6},{"id":"GO:0007409","count":6},{"id":"GO:0010800","count":6}]},{"hash":"677857470873150413","title":"Golgi-to-plasma membrane trafficking and recycling","description":"The top GO terms center on Golgi-to-plasma membrane transport and endocytic recycling, indicating a membrane trafficking core. Related terms for membrane addition during cytokinesis, cell fusion, and Rap-mediated signaling further tie trafficking to membrane dynamics in migration and development.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006893","count":3},{"id":"GO:0032456","count":3},{"id":"GO:0010762","count":2},{"id":"GO:0031584","count":2},{"id":"GO:0035564","count":2}]},{"hash":"2140508336750041985","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045493","count":1},{"id":"GO:0016042","count":1},{"id":"GO:2000344","count":1},{"id":"GO:2000884","count":1},{"id":"GO:0007283","count":1}]},{"hash":"1320500963350036351","title":"Multicellular Development and Pigmentation","description":"Most top GO terms cluster around developmental processes across tissues (brain, retina, gonads) and organismal growth, with pigmentation as another developmental trait. A few terms for rRNA maturation and spindle orientation seem more general/cellular, possibly annotation noise, but the dominant theme is multicellular development and growth. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0000463","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0043473","count":3},{"id":"GO:0008584","count":3}]},{"hash":"1051869149160146144","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning vision-related processes (phototransduction, visual learning) and muscle/calcium signaling plus immune and neurotransmitter metabolism, with no clear single shared function or pathway across the proteins. There are no observed interactions (Edges 0), making it hard to anchor a cohesive label.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030827","count":1},{"id":"GO:1901898","count":1},{"id":"GO:0019934","count":1},{"id":"GO:0007603","count":1},{"id":"GO:0042428","count":1}]},{"hash":"2008781871589932499","title":"Complement and Platelet Immune Activation","description":"The cluster centers on GO terms for complement activation (classical and alternative), platelet activation, and phagolysosome assembly, with supporting signals for cell adhesion and angiogenesis. This pattern points to a functional module of immune defense in which complement drives defense, platelets participate in activation and adhesion, and phagolysosome processing mediates pathogen clearance. A few development-related terms appear, but the dominant theme remains immune activation and platelet\u2013phagocyte interactions.","confidence":"Medium","size":7,"edges":9,"triangles":3,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0006590","count":3},{"id":"GO:0001845","count":3},{"id":"GO:0039573","count":3}]},{"hash":"1157374866352789858","title":"Angiogenesis and Endothelial Signaling","description":"This cluster is dominated by terms related to blood vessel formation and endothelial cell behavior (angiogenesis, endothelial migration, Tie signaling, ERK cascade). The inclusion of inflammatory (IL-6 response) and coagulation terms suggests a vascular biology context where angiogenic signaling intersects with inflammatory and hemostatic processes, making \u201cAngiogenesis and Endothelial Signaling\u201d a representative label.","confidence":"High","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":1},{"id":"GO:0002752","count":1},{"id":"GO:0001525","count":1},{"id":"GO:0072377","count":1},{"id":"GO:0043536","count":1}]},{"hash":"362777675015018535","title":"Developmental and immune differentiation signals","description":"The cluster\u2019s top GO terms cluster around development and immune differentiation, notably mesodermal cell differentiation (GO:0048333), negative regulation of Notch signaling (GO:0045746), recognition of apoptotic cell (GO:0043654), and positive regulation of B cell differentiation (GO:0045579). This suggests a shared theme in developmental signaling and immune cell differentiation, even though a few terms relate to general ion transport or metabolism (copper/calcium transport, epoxygenase P450 pathways) that may reflect broader cellular roles or annotation noise. ","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043654","count":2},{"id":"GO:0048333","count":2},{"id":"GO:0045746","count":2},{"id":"GO:0006825","count":1},{"id":"GO:0032534","count":1}]},{"hash":"72815933273955084","title":"Diverse biosynthetic pathways","description":"Top GO terms span multiple biosynthetic processes (sterol, biotin, ubiquinone, polyamine, chlorophyll) and RNA-related steps (tRNA wobble modification, ribosomal export), plus nodulation. This mix points to proteins involved in a range of biosynthetic and related activities rather than a single specific function, justifying the label. Confidence: Medium","confidence":"","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0002098","count":2},{"id":"GO:0016126","count":1},{"id":"GO:0009877","count":1},{"id":"GO:0019505","count":1},{"id":"GO:0000056","count":1}]},{"hash":"33597359969269815","title":"Ubiquitin-Proteasome Regulation in Neuronal Circadian Control","description":"A cluster dominated by ubiquitin-dependent protein catabolic processes (including SCF-dependent degradation) and circadian rhythm regulation, with neuronal context such as synapse assembly and neuron-intrinsic apoptotic signaling, suggesting a coherent role for ubiquitin-proteasome pathways in neuronal circadian control and stress responses.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0042752","count":5},{"id":"GO:0031571","count":4},{"id":"GO:0060386","count":4},{"id":"GO:0031146","count":4}]},{"hash":"190904317460416078","title":"Organogenesis and vascular morphogenesis","description":"The terms center on development and morphogenesis of tissues, especially vascular/endothelial structures (endothelial barrier establishment, endothelial tube lumen extension) and heart/kidney organ systems (mitral valve formation, nephron tubule differentiation), with cadherin-mediated cell adhesion supporting tissue organization. Some annotations (melanin biosynthesis, STAT phosphorylation) are less connected, but the dominant theme is organogenesis with a vascular/structure-formation emphasis.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048023","count":2},{"id":"GO:1903263","count":2},{"id":"GO:0044331","count":2},{"id":"GO:0072307","count":2},{"id":"GO:1903142","count":2}]},{"hash":"1823163166033275286","title":"Inflammation and vascular regulation","description":"The cluster shows strong representation of inflammatory response, LPS response, IL-1\u03b2 production, blood coagulation, and vasoconstriction, pointing to a coordinated immune and vascular function. Some terms about pain and locomotion are present but appear secondary to the core inflammatory/vascular theme.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0045907","count":3}]},{"hash":"1694495377437160248","title":"DNA Replication and Cellular Stress Proteostasis","description":"This cluster combines GO terms for DNA replication and cell division with multiple proteostasis and stress-response pathways (ER unfolded protein response, ER-associated degradation, proteasomal degradation, stress granule disassembly, and translesion synthesis). The concurrence of genome duplication processes with protein quality control and ER stress\u2013related processes suggests a cohesive theme of coordinating DNA replication with proteostasis under cellular stress, with vesicle transport possibly supporting these quality-control activities.","confidence":"Medium","size":7,"edges":8,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019079","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0035617","count":3},{"id":"GO:2001171","count":2},{"id":"GO:0071712","count":2}]},{"hash":"1474466281246649526","title":"Neural development and embryogenesis","description":"The terms are dominated by neural development and embryonic processes: positive regulation of neural precursor proliferation, neuron projection development, dopamine biosynthesis, and in utero embryonic development/gastrulation. While some terms (glycolysis, LPS response) are more general or stress-related, they appear as secondary signals, making neural differentiation and early development the most representative theme of this cluster.","confidence":"High","size":7,"edges":14,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:2000179","count":3},{"id":"GO:0042416","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0010725","count":2}]},{"hash":"1502529813431503892","title":"C-type lectin receptor\u2013driven innate immune signaling","description":"The strongest GO terms point to innate immune sensing and leukocyte activation: stimulatory C-type lectin receptor signaling, phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and NK cell chemotaxis regulation. These collectively support a label of innate immune signaling/activation, though a few cartilage/ossification-related terms appear as less-connected outliers.","confidence":"Medium","size":7,"edges":14,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":4},{"id":"GO:0010572","count":4},{"id":"GO:0001957","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0006910","count":3}]},{"hash":"553226867521017855","title":"Calcium signaling and actin remodeling","description":"This cluster is dominated by calcium-related signaling terms (calcium modulation in Wnt, calcium channel activity, calcium import regulation) along with actin filament organization and muscle-related processes (diaphragm contraction). The presence of insulin secretion regulation and EMT hints at broader signaling-driven remodeling. Together, these point to calcium-dependent signaling coupled with cytoskeletal dynamics as the core theme.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0001837","count":7},{"id":"GO:0007223","count":7},{"id":"GO:0035774","count":7},{"id":"GO:0010886","count":7},{"id":"GO:1901841","count":7}]},{"hash":"200323264633612890","title":"Epigenetic Chromatin Regulation","description":"Consistent signals come from GO terms referencing heterochromatin assembly, H3K9 dimethylation, and DNA methylation, all indicative of chromatin state control and epigenetic modification. While several terms related to cardiac development and light response appear, they are less cohesive with the core chromatin theme and may be false positives or species-specific annotations. Overall, the cluster centers on epigenetic regulation of chromatin rather than a single developmental pathway.","confidence":"Medium","size":7,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033697","count":2},{"id":"GO:0036123","count":2},{"id":"GO:0010425","count":2},{"id":"GO:0036302","count":2},{"id":"GO:0009416","count":2}]},{"hash":"174934186810995107","title":"RNA Processing and mRNA Decay","description":"The top GO terms are dominated by RNA metabolism activities: splicing (spliceosomal assembly, mRNA splicing), rRNA maturation, and mRNA turnover (P-body assembly, deadenylation-dependent decapping), plus transcription termination and nuclear import. This points to a cohesive cluster of proteins involved in RNA processing, surveillance, and transport, with a few secondary associations such as chromatin-related terms. Confidence: High","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":5},{"id":"GO:0000245","count":3},{"id":"GO:1990141","count":3},{"id":"GO:0030490","count":3},{"id":"GO:0033962","count":3}]},{"hash":"1298025122061502816","title":"Cell Cycle Regulation and Mitochondrial Metabolism","description":"This cluster centers on cell cycle control (cell cycle, regulation of cell cycle, positive regulation of cell population proliferation) and mitochondrial energy pathways (oxidative phosphorylation, TCA cycle, acetyl-CoA biosynthesis, succinyl-CoA metabolism), with supporting signals from RNA processing and iron-sulfur cluster assembly that tie metabolism to growth. The shared themes suggest coordinated cell growth with energy production.","confidence":"Medium","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1903705","count":1},{"id":"GO:0008284","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0071850","count":1},{"id":"GO:1903862","count":1}]},{"hash":"222618903467971726","title":"Plant Biosynthesis and Ribosome Biogenesis","description":"These proteins appear to participate in multiple biosynthetic pathways (sterol, biotin, ubiquinone, polyamine, chlorophyll) and in ribosome-related processes (rRNA methylation, export of the small subunit), with nodulation and chlorophyll biosynthesis indicating plant-specific biology. The shared theme is a plant-centered set of metabolic biosynthesis activities coupled with ribosome biogenesis, rather than a single highly specific function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":3},{"id":"GO:0009877","count":3},{"id":"GO:0019505","count":3},{"id":"GO:0000056","count":3},{"id":"GO:0090398","count":3}]},{"hash":"1718576515427969850","title":"Nucleotide Biosynthesis and Salvage","description":"This cluster shows strong enrichment for deoxyribonucleoside salvage, dGTP and TMP biosynthesis, and broader DNA biosynthetic processes, indicating a coherent role in maintaining the nucleotide pools needed for DNA replication and repair. A single Wnt signaling term exists but does not dominate the set; the nucleotide metabolism theme best explains the cluster.","confidence":"High","size":7,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0006180","count":2},{"id":"GO:0046070","count":2},{"id":"GO:0043097","count":2},{"id":"GO:0071897","count":2}]},{"hash":"1043363578977631230","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":13,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0000463","count":2},{"id":"GO:1903608","count":2},{"id":"GO:0045003","count":2},{"id":"GO:0070870","count":2}]},{"hash":"579592859528597293","title":"Embryonic Development and Transcription Regulation","description":"Proteins in this cluster are enriched for transcription-related GO terms (DNA-templated transcription; negative regulation of transcription by RNA polymerase II) and for diverse embryonic morphogenesis processes (hindlimb, heart, eye, placenta, habenula, gonads, prostate). This points to a set of transcriptional regulators that coordinate gene expression during embryonic development across multiple tissues, justifying the label.","confidence":"High","size":7,"edges":16,"triangles":16,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0035116","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1604531592454354773","title":"Cell cycle regulation and signaling","description":"The cluster is best described as cell cycle control and signaling regulation, since major terms center on regulating cell cycle progression, kinase activity, and signaling pathways (insulin and glucocorticoid), with support from protein interactions and growth-related processes; some terms are developmental or vesicular, but the core theme is growth/division control via signaling.","confidence":"Medium","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:0048496","count":2},{"id":"GO:0007050","count":2},{"id":"GO:0000011","count":2},{"id":"GO:0015991","count":2}]},{"hash":"990860597235957212","title":"GPCR Signaling and Epithelial Polarity","description":"The cluster centers on GPCR-related signaling pathways (adenylate cyclase-inhibiting GPCR signaling, sphingosine-1-phosphate receptor signaling, forskolin response) and processes maintaining epithelial cell architecture (apical/basal polarity, tight junction assembly). The inclusion of phototransduction and taste-related terms reflects sensory GPCR signaling, reinforcing a common theme of GPCR-driven communication, with epithelial polarity providing a unifying cellular context. Some cell cycle terms appear tangentially, but overall the dominant pattern is signaling and polarity. ","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0070830","count":5},{"id":"GO:0007603","count":5},{"id":"GO:0007193","count":5}]},{"hash":"548871156302390786","title":"Nucleotide, amino acid, and cofactor biosynthesis","description":"This cluster\u2019s top GO terms span several biosynthetic pathways: purine nucleotides and nucleobases, L-histidine biosynthesis, S-adenosylmethionine (SAM) biosynthesis, 10-formyltetrahydrofolate biosynthesis, poly-hydroxybutyrate biosynthesis, and antibiotic biosynthetic processes. Together they point to a collection of proteins involved in diverse biosynthetic and cofactor-producing processes rather than a single specific function, justifying a label focused on biosynthesis. ","confidence":"Medium","size":7,"edges":13,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0006556","count":2}]},{"hash":"588273869220921931","title":"Actin Dynamics and Vesicle Exocytosis Regulation","description":"The cluster shows strong representation of actin polymerization, stress fiber assembly, and formin-nucleated actin cable assembly, together with regulation of synaptic vesicle exocytosis, suggesting a core theme of actin-driven remodeling linked to membrane trafficking and secretion. Peripheral terms on lipid homeostasis and development may relate to membranes or organogenesis but do not override the central actin/vesicle regulation signal.","confidence":"Medium","size":7,"edges":16,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050885","count":4},{"id":"GO:0042632","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0055091","count":3},{"id":"GO:0051496","count":3}]},{"hash":"1323267047695543309","title":"Cytoskeleton remodeling and cell adhesion signaling","description":"The terms converge on cytoskeletal dynamics and cell\u2013cell interfaces: microtubule binding regulation, cleavage furrow formation, filopodium assembly, adherens junction protein localization, and substrate-dependent cell spreading, all of which reflect coordinated remodeling and adhesion signaling driving cell movement and organization. While some GO terms relate to broader signaling and immune processes, the dominant theme is cytoskeletal organization and junctional signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904528","count":2},{"id":"GO:0036089","count":2},{"id":"GO:1903912","count":2},{"id":"GO:0032005","count":2},{"id":"GO:1904703","count":2}]},{"hash":"243570060338392228","title":"Glycan biosynthesis and AGP-related development","description":"The cluster is enriched for glycan/glycoprotein processes (poly-N-acetyllactosamine biosynthesis; O-linked glycosylation via hydroxyproline; Lewis a epitope biosynthesis) and arabinogalactan protein metabolism, with several plant-development terms (root hair development, seed coat mucilage biosynthesis). This points to a unifying theme of glycosylation and glycoprotein-mediated cell-surface development, spanning plant contexts and broader developmental roles. ","confidence":"Medium","size":7,"edges":14,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0030311","count":2},{"id":"GO:0018258","count":2},{"id":"GO:0048354","count":2}]},{"hash":"589784540746857609","title":"Amino acid biosynthesis and catabolism","description":"This cluster shows strong representation of both amino acid biosynthetic (tryptophan, threonine, isoleucine, serine) and catabolic/related processes (amine catabolic, transsulfuration) along with links to central metabolism (pyruvate biosynthesis), and even a cyanide metabolic angle. The shared theme is amino acid metabolism in both building blocks and breakdown pathways, making this label representative.","confidence":"High","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006565","count":4},{"id":"GO:0009310","count":3},{"id":"GO:0000162","count":3},{"id":"GO:0019499","count":3},{"id":"GO:0042866","count":3}]},{"hash":"2033499983368043596","title":"Unknown","description":"The GO terms include development (root, neural plate, oocyte), cell cycle regulation, cytoskeletal localization, primitive pseudopodium assembly, and Toll-like receptor signaling, reflecting diverse roles with no obvious single shared function.","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":4},{"id":"GO:0048364","count":3},{"id":"GO:0001840","count":3},{"id":"GO:0080034","count":3},{"id":"GO:0086073","count":3}]},{"hash":"1878948323156819659","title":"Neural development and neuroimmune signaling","description":"The Top Terms strongly emphasize CNS neuron development, dendrite morphogenesis, corpus callosum development, and dopamine-related responses, pointing to neural development and neurosignaling. At the same time, innate immune terms (innate immune response, LPS response, defense against Gram-positive bacteria, interferon-beta production) suggest immune signaling components. The cluster appears to include proteins involved in brain development with concurrent immune signaling, supporting a neuroimmune interpretation. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021954","count":4},{"id":"GO:0048813","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0071222","count":4}]},{"hash":"1610946967563003700","title":"Viral genome integration and latency","description":"The top GO terms cluster around virus-host interactions: entry of symbionts/viruses into host cells and nuclei, proviral latency establishment, and DNA integration, DNA replication, and recombination, along with host transcription regulation and RNA interference processing\u2014together representing viral genome integration and manipulation of host cells.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0006310","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0006278","count":2}]},{"hash":"97861538136116181","title":"Immune Response Modulation","description":"This cluster centers on immune signaling and regulation: multiple terms point to negative regulation of key signaling pathways (IL-2, TLR9, p38 MAPK, PDGFR\u03b2) and a term for positive regulation of granzyme B production, suggesting modulation of immune/cytotoxic responses. Additional terms like response to muramyl dipeptide and regulation of integrin-mediated adhesion align with immune receptor signaling and cell interactions. A single outlier (vestibular receptor morphogenesis) may reflect annotation noise rather than a true functional link. Medium","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902206","count":4},{"id":"GO:2000646","count":4},{"id":"GO:0060116","count":4},{"id":"GO:0071225","count":4},{"id":"GO:0033629","count":4}]},{"hash":"806651543182039139","title":"Meiosis and DNA Recombination Machinery","description":"The top terms cluster around meiotic chromosome events (synaptonemal complex assembly, sister chromatid cohesion in female meiosis, oocyte maturation) and DNA recombination/replication processes (DNA recombination, DNA duplex unwinding, replication stress response). While there are some stress or inflammatory response terms present, the dominant signals point to meiosis and DNA repair/recombination machinery as the core function of this protein set.","confidence":"High","size":7,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0032508","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0002526","count":2},{"id":"GO:0001556","count":1}]},{"hash":"2220758133029184464","title":"Mitotic Chromosome Alignment and Spindle Regulation","description":"The top GO terms collectively point to mitotic processes: spindle orientation checkpoint signaling, sister chromatid biorientation, and establishment of protein localization to chromosomes are core aspects of chromosome segregation during mitosis. Additional terms like protein dephosphorylation and general signal transduction suggest regulatory control of this process. Some outliers (P granule assembly, neurotrophin signaling) may reflect broader regulatory roles or annotation noise, but the dominant theme is mitotic chromosome handling and spindle regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":2},{"id":"GO:1903863","count":2},{"id":"GO:0031107","count":2},{"id":"GO:0031578","count":2},{"id":"GO:0031134","count":2}]},{"hash":"2176923235560594583","title":"Chromatin Modification and Transcription Regulation","description":"The top GO terms are dominated by transcriptional regulation and chromatin modification activities, including negative regulation of RNA Pol II transcription, histone methylation, and PRMT-mediated arginine methylation, pointing to a cluster focused on controlling gene expression through chromatin state and transcription machinery. While some terms touch on apoptosis or development, the strongest, coherent signal is chromatin-associated transcriptional control.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0034970","count":2},{"id":"GO:0043985","count":2},{"id":"GO:0019919","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1332312099821971357","title":"Neural Development and Dendrite Morphogenesis","description":"The top GO terms are dominated by nervous system development, forebrain development, neural tube closure, and dendrite morphogenesis, pointing to neural structure and development as the core theme. While there are additional, less central terms related to ER-stress\u2013induced apoptosis, cadmium response, and general cell cycle/DNA replication, they appear peripheral to the main function. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070059","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0007399","count":3}]},{"hash":"1003725311556442729","title":"Protein catabolism and amino acid degradation","description":"This cluster centers on protein turnover and amino acid degradation, with strong signals from proteolysis and peptide catabolic process, plus allantoin and ureide catabolic pathways suggesting nitrogen recycling. Obsolete lysine biosynthesis terms and a few developmental/behavioral terms likely reflect annotation noise rather than a cohesive core function. The absence of interactions (edges/triangles) further points to a weakly cohesive signal beyond catabolic processes.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0009791","count":2},{"id":"GO:0035641","count":1},{"id":"GO:0019878","count":1},{"id":"GO:0043171","count":1}]},{"hash":"1638318470047686553","title":"Developmental gene regulation","description":"The top terms cluster around RNA-based control of gene expression (miRNA silencing and miRNA metabolism) and protein homeostasis (ubiquitin-dependent degradation and autophagy), with supporting developmental processes (stem cell proliferation, placenta morphogenesis) and adhesion. This suggests a cohesive theme of regulating development through gene expression and protein turnover, hence \u201cDevelopmental gene regulation.\u201d ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000637","count":3},{"id":"GO:0007160","count":2},{"id":"GO:0006914","count":2},{"id":"GO:1900458","count":2},{"id":"GO:0072089","count":2}]},{"hash":"1817455334891863015","title":"Lipid metabolism and membrane trafficking","description":"Proteins in this cluster are enriched for lipid-related processes, including fatty acid metabolic process, triglyceride catabolic process, and depalmitoylation, along with a term on negative regulation of Golgi to plasma membrane transport. These lipid metabolism and membrane trafficking signals appear as the strongest shared themes, with other terms being less central, supporting a label focused on lipid processing and membrane trafficking. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002084","count":3},{"id":"GO:0042997","count":3},{"id":"GO:0006631","count":3},{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2}]},{"hash":"673745251941060967","title":"Unknown","description":"The terms include blood coagulation, complement activation, cell adhesion, ECM regulation, and ubiquitin-dependent protein catabolism, but also plant-specific processes (chlorophyll biosynthesis, stamen formation) and neural remodeling (dendrite regeneration), with no clear shared pathway and no edges among proteins. This lack of a cohesive function makes a single meaningful label untenable.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0030212","count":4},{"id":"GO:0045123","count":4},{"id":"GO:0034113","count":4},{"id":"GO:0006511","count":4}]},{"hash":"43086788114436618","title":"Unknown","description":"The terms span neuronal localization/development, immune signaling regulation, and differentiation/angiogenesis, with several obsolete entries. They do not converge on a single biological function or pathway, so a specific, representative label cannot be confidently assigned.","confidence":"","size":7,"edges":18,"triangles":21,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":1},{"id":"GO:0021740","count":1},{"id":"GO:0038033","count":1},{"id":"GO:1904604","count":1},{"id":"GO:0002859","count":1}]},{"hash":"1071272824070179496","title":"Immune Activation and Antigen Presentation","description":"The cluster shows strong representation of immune-related processes: adaptive immune response, antigen processing and presentation via MHC class Ib, monocyte differentiation, and neutrophil-mediated responses, plus regulation of TLR signaling and mast cell activity. While there are a few non-immune terms in the mix, the majority of terms point to activation and modulation of immune responses, including innate and adaptive arms. This justifies a label focused on immune activation and antigen presentation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030224","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0048007","count":1},{"id":"GO:0021740","count":1},{"id":"GO:0038033","count":1}]},{"hash":"2279197923028550914","title":"Inflammation and vascular signaling","description":"Most of the top GO terms point to inflammatory and vascular processes (regulation of IL-1 beta production; cellular response to prostaglandin E; blood coagulation; positive regulation of cardiac vascular smooth muscle cell differentiation). The calcium release term supports signaling events connected to these pathways. A few terms relate to neural/behavioral aspects (grooming, phototransduction, appetite), which are less central to the core theme, likely reflecting broader multifunctionality or annotation noise. Overall, the cluster is best described as an inflammation- and vascular-signaling module.","confidence":"Medium","size":7,"edges":10,"triangles":3,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":7},{"id":"GO:0051209","count":7},{"id":"GO:0071380","count":7},{"id":"GO:0007596","count":7},{"id":"GO:2000724","count":7}]},{"hash":"1083493398270133091","title":"Mitotic spindle organization and cell cycle control","description":"The Top Terms are dominated by mitosis-related processes (mitotic spindle organization, centrosome separation, spindle-kinetochore attachment, and G1 DNA damage checkpoint signaling), indicating a cohesive theme around the mitotic apparatus and cell cycle regulation. While there are a few unrelated stress-response terms, they are not as prominent, so the core function of the cluster appears to center on mitosis and cell-cycle control.","confidence":"High","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071333","count":6},{"id":"GO:0043330","count":6},{"id":"GO:0051316","count":4},{"id":"GO:0000189","count":4},{"id":"GO:0007070","count":4}]},{"hash":"1983970508810597810","title":"Unknown","description":"The top GO terms include diverse lipid metabolism (prostaglandin, unsaturated fatty acid and ergosterol/sphingolipid processes), sterol regulation, nitric oxide and nitrogen metabolism, and even organism-specific differentiation and nervous system maintenance. This broad mix lacks a single cohesive function or pathway that ties the proteins together across contexts, making a concise representative label difficult. ","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":3},{"id":"GO:0001949","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0006636","count":2},{"id":"GO:0032443","count":2}]},{"hash":"1016010891837605296","title":"Lipid metabolism and sterol biosynthesis","description":"This cluster\u2019s top terms cluster around lipid-related processes: fatty acid biosynthesis and response, cholesterol esterification (even if obsolete), and regulation of sterol biosynthesis (ergosterol), along with adipocyte differentiation and myelin-associated lipid maintenance. While a few terms (mitochondrial inheritance, photoinhibition, nitric oxide biosynthesis) are peripheral, the dominant signal points to lipid metabolism and sterol biosynthesis as the shared function.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010205","count":2},{"id":"GO:0010873","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0050872","count":2}]},{"hash":"606472713110623875","title":"Polysaccharide biosynthesis and carbohydrate metabolism","description":"The top GO terms point to sugar metabolism and production of complex carbohydrates (glycogen biosynthesis; galactose, glucose-1-phosphate, and GDP-mannose metabolism) as well as biosynthesis of surface polysaccharides like O antigens and lipopolysaccharides, with cell wall organization also appearing. These together suggest a cohesive theme around polysaccharide biosynthesis and carbohydrate metabolic processes; the gravity detection term seems unrelated and likely an annotation outlier. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":1},{"id":"GO:0046115","count":1},{"id":"GO:0006148","count":1},{"id":"GO:0009243","count":1},{"id":"GO:0019388","count":1}]},{"hash":"58367227606761178","title":"Neuronal signaling and sensory system development","description":"The top GO terms cluster around neurotransmitter signaling (serotonin, dopamine), synaptic transmission (cholinergic), and membrane depolarization, coupled with developmental terms for sensory pathways (lateral geniculate nucleus, vestibulocochlear nerve) and behaviors like locomotion and autonomic regulation, indicating a group of proteins involved in neuronal signaling and sensory system development.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0033603","count":7},{"id":"GO:0001988","count":7},{"id":"GO:0021771","count":7}]},{"hash":"545907143392215721","title":"Zinc ion uptake and homeostasis","description":"This cluster is dominated by GO terms related to zinc biology: zinc ion import across the plasma membrane, intracellular zinc ion homeostasis, detoxification, and cellular responses to zinc ion status. These points indicate proteins involved in zinc transport and maintenance of zinc levels. Other terms (limb development, interferon-beta response) are less central and likely incidental. Therefore, a label centered on zinc transport and homeostasis best represents the cluster.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0034224","count":2},{"id":"GO:0010312","count":2},{"id":"GO:0006830","count":2},{"id":"GO:0006882","count":2},{"id":"GO:0006831","count":2}]},{"hash":"1416408401026760188","title":"Membrane nutrient transporters","description":"Most GO terms describe transmembrane transport of small molecules (glucose, myo-inositol, pantothenate, biotin, thiamine) or ions (sodium), suggesting these proteins function as membrane transporters or solute carriers. An outlier term for acetylcholine biosynthesis exists, but the dominant pattern supports a transporter-focused cluster. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008292","count":1},{"id":"GO:0071436","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0015887","count":1}]},{"hash":"807976367607946101","title":"Nephron Morphogenesis and Actin Remodeling","description":"The top GO terms strongly point to kidney development, with glomerulus morphogenesis and nephron tubule epithelial cell differentiation, accompanied by actin cytoskeleton remodeling processes (actin filament bundle assembly, lamellipodium organization, actin polymerization regulation, and membrane organization). This suggests a cluster of proteins coordinating nephron morphogenesis through dynamic cytoskeletal and membrane reorganization.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072102","count":3},{"id":"GO:0051017","count":2},{"id":"GO:0097581","count":2},{"id":"GO:2000251","count":2},{"id":"GO:0072160","count":2}]},{"hash":"1419245061566935896","title":"Developmental morphogenesis and cytoskeletal regulation","description":"The terms point to developmental processes (mesenchyme migration, skeletal muscle development/adaptation, substantia nigra development) and cytoskeletal/endocytic dynamics (actin patch assembly, regulation of endocytosis, mitochondrial inheritance), suggesting a theme around tissue morphogenesis supported by cytoskeletal remodeling rather than a single narrow function.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043983","count":1},{"id":"GO:0000147","count":1},{"id":"GO:0002121","count":1},{"id":"GO:0030100","count":1},{"id":"GO:0090131","count":1}]},{"hash":"13868301316268750","title":"Ribosome biogenesis and development","description":"The prominent ribosome-related terms (ribosome biogenesis, rRNA maturation, RNA methylation) indicate a core role in protein synthesis, while the concurrent development terms (skin, spinal cord, seminiferous tubule, growth, proliferation) suggest these proteins are also involved in tissue development and growth programs.","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0072520","count":2}]},{"hash":"941223110604743260","title":"ER Protein Folding and Quality Control","description":"The cluster is dominated by GO terms related to protein folding, chaperone-assisted refolding, ER targeting/membrane translocation, and ER-associated degradation, along with redox homeostasis and stress responses. These together point to a module focused on correct protein maturation and quality control in the endoplasmic reticulum, despite a few outlier terms (like DNA replication) that may reflect noise or multifunctionality. ","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0031204","count":6},{"id":"GO:1900035","count":6},{"id":"GO:0090084","count":6}]},{"hash":"760307536167439042","title":"Cytoplasmic translation and ribosome biogenesis","description":"This cluster shows strong enrichment for cytoplasmic translation and ribosome-related processes (cytoplasmic translation, ribosome biogenesis, SRP-dependent cotranslational targeting to membrane, ribosomal large subunit assembly). A few single-count terms touch on immune signaling and development, but the dominant theme is the protein synthesis machinery, so the label reflects the core function of the cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0046632","count":1},{"id":"GO:0071353","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006614","count":1}]},{"hash":"102621699609785149","title":"Developmental signaling and differentiation","description":"This cluster centers on developmental cues and cell fate decisions, with enrichment in Wnt signaling regulation, myoblast fusion, and keratinocyte differentiation, plus neural synaptic transmission and apoptosis regulation, all pointing to roles in tissue development and differentiation across multiple cell types. Some terms are obsolete or non-mammalian, but the core recurring theme is signaling and differentiation processes shaping development.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":5},{"id":"GO:0001324","count":4},{"id":"GO:0035249","count":4},{"id":"GO:0043065","count":4},{"id":"GO:0006915","count":4}]},{"hash":"217260841457488139","title":"BMP-driven cartilage and tooth mineralization","description":"The GO terms point to BMP signaling and responses (cellular response to BMP stimulus; SMAD regulation) with downstream effects on cartilage development and tooth mineralization, suggesting a BMP-regulated skeletal/dental tissue formation theme. Additional terms related to extracellular matrix remodeling (peptide cross-linking) and vascular-associated processes can accompany mineralization contexts, supporting a cohesive axis around BMP-mediated skeletal and dental tissue formation. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018149","count":1},{"id":"GO:0007596","count":1},{"id":"GO:1903225","count":1},{"id":"GO:0090027","count":1},{"id":"GO:0061036","count":1}]},{"hash":"1050546147712026583","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0000453","count":1},{"id":"GO:0050843","count":1},{"id":"GO:0019354","count":1},{"id":"GO:0017183","count":1}]},{"hash":"2086179313397141684","title":"Cytoskeletal Dynamics in Muscle and Development","description":"The cluster\u2019s top GO terms center on actin cytoskeleton remodeling (actin cortical patch assembly), endocytosis regulation, and cell movement (mesenchyme migration), with strong signals for skeletal muscle fiber development/adaptation. These point to a theme of cytoskeletal remodeling driving muscle and developmental processes, with broader contributions to neural development such as substantia nigra development. Overall, the dominant signal is cytoskeletal dynamics linked to development and tissue formation.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043983","count":6},{"id":"GO:0000147","count":6},{"id":"GO:0002121","count":6},{"id":"GO:0030100","count":6},{"id":"GO:0090131","count":6}]},{"hash":"1275890797806433061","title":"Unknown","description":"The top GO terms span neural signaling (membrane potential, calcium release, phototransduction, grooming behavior, appetite), inflammatory/prostaglandin responses, coagulation, and vascular differentiation, with no single cohesive function tying all six proteins together. This diversity suggests the cluster does not represent one specific biological process.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042391","count":3},{"id":"GO:0032651","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0007596","count":2}]},{"hash":"1361120662149573738","title":"Ribosome biogenesis and translation initiation","description":"The top terms center on RNA processing and ribosome assembly (small-subunit processome), mRNA export, and initiation of translation (eIF4F complex assembly and related initiation pathways), indicating a cluster focused on ribosome biogenesis and translation control. Some obsolete terms appear, but the core theme remains RNA maturation and protein synthesis initiation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034462","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0097010","count":1},{"id":"GO:0075522","count":1},{"id":"GO:0006406","count":1}]},{"hash":"969832797950533883","title":"DNA Repair, Telomere Maintenance, and Immune Recombination","description":"The cluster shows strong signals for DNA damage response and telomere biology, including nonhomologous end joining (double-strand break repair), telomere maintenance and telomeric loop formation, and V(D)J recombination, plus associated B cell differentiation. This points to a cohesive theme of genome integrity and immune system\u2013related recombination, with some peripheral terms likely reflecting noise or broader biological contexts.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061408","count":2},{"id":"GO:0048316","count":1},{"id":"GO:0010833","count":1},{"id":"GO:2000685","count":1},{"id":"GO:1904975","count":1}]},{"hash":"2140724865023146996","title":"Unknown","description":"The top GO terms are diverse and sparse, covering neural development (paranode axon localization, trigeminal nerve development), endothelial/VEGF signaling, embryonic development, and immune regulation (NK cell activity, IL-1 signaling, NF-kB, mast cell activation). There isn\u2019t a single coherent function or pathway tying these proteins together, and several terms are obsolete or only weakly connected, so no clear label emerges beyond Unknown.","confidence":"","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":1},{"id":"GO:1902960","count":1},{"id":"GO:0021740","count":1},{"id":"GO:0038033","count":1},{"id":"GO:0001701","count":1}]},{"hash":"297251562155136627","title":"Negative Regulators of Immune Signaling","description":"This cluster is dominated by GO terms for downregulating signaling pathways involved in inflammation and immunity (e.g., VEGF, IL-2, TLR9, and p38 MAPK cascades, and integrin-mediated adhesion), plus a muramyl dipeptide response, indicating modulation of innate immune signaling. The presence of granzyme B regulation adds a cytotoxic dimension but the overall pattern points to immune signaling inhibition and regulation.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":5},{"id":"GO:1902206","count":4},{"id":"GO:2000646","count":4},{"id":"GO:0060116","count":4},{"id":"GO:0071225","count":4}]},{"hash":"121477610353810385","title":"Unknown","description":"These GO terms show a scattered mix of plant development and stress-related processes (jasmonic acid response, vegetative growth, seed growth, secondary cell wall biogenesis, osmotic stress) alongside unrelated terms (viral process, shelterin complex assembly) and an obsolete deubiquitination term. There is no clear, cohesive functional theme linking all six proteins, so a single, specific label cannot be confidently assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035522","count":1},{"id":"GO:0009753","count":1},{"id":"GO:1900033","count":1},{"id":"GO:1905615","count":1},{"id":"GO:0016032","count":1}]},{"hash":"816521832962244180","title":"RNA processing and translation regulation","description":"Top GO terms point to RNA metabolism and gene expression control, including ncRNA-mediated silencing, mRNA splicing via the spliceosome, processome assembly, mRNA export, polyadenylation, and assembly of translation initiation complexes (eIF4F) or IRES-dependent initiation. Together these terms suggest a functional cluster of proteins involved in RNA processing and regulating translation rather than a single isolated process.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0034462","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0097010","count":2}]},{"hash":"2204332454086409801","title":"Unknown","description":"This cluster shows a highly heterogeneous mix of GO terms (habituation; embryonic development; IL-2 signaling regulation; mitotic spindle and contractile ring processes; vestibular morphogenesis; immune and adhesion-related responses), with no single dominant function tying the proteins together. Connectivity is minimal (Edges: 1, Triangles: 0) and several terms are obsolete or unrelated, suggesting either annotation noise or a non-coherent collection rather than a shared biological process. Therefore Unknown with no clear functional theme.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046959","count":2},{"id":"GO:0045204","count":2},{"id":"GO:0001701","count":2},{"id":"GO:1902206","count":2},{"id":"GO:2000646","count":2}]},{"hash":"1896678560363075688","title":"Unknown","description":"The top GO terms cover a wide and seemingly unrelated mix of processes (blood coagulation, acute-phase response, cell adhesion/extravasation, ubiquitin-dependent protein degradation, and plant-specific processes like chlorophyll biosynthesis and stamen formation). There\u2019s no clear common function or theme tying these proteins together, suggesting annotation noise or cross-species/artefactual associations. Therefore no cohesive label can be assigned with confidence.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":1},{"id":"GO:0006471","count":1},{"id":"GO:0030212","count":1},{"id":"GO:0045123","count":1},{"id":"GO:0034113","count":1}]},{"hash":"2238591130210171969","title":"Unknown","description":"There is no connectivity or shared GO terms among these proteins (0 edges, 0 triangles, and no top terms), so there isn\u2019t a detectable common function to label. The lack of functional signal leads to the Unknown classification.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"416948051494443801","title":"Developmental signaling and differentiation","description":"This cluster shows a broad set of GO terms tied to signaling pathways that regulate development and differentiation across tissues\u2014neural transmission, axon organization, BMP and Hedgehog signaling, adenosine receptor signaling, and STAT phosphorylation\u2014along with tissue development terms like kidney and salivary gland specification and myoblast differentiation. The common theme is developmental signal transduction rather than a single precise process, so a general label capturing developmental signaling/differentiation is appropriate.","confidence":"Medium","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":3},{"id":"GO:0002175","count":2},{"id":"GO:0045663","count":2},{"id":"GO:0034164","count":2},{"id":"GO:0060168","count":2}]},{"hash":"1231063454505433213","title":"Unknown","description":"The top GO terms cover several disparate processes (epithelial\u2013mesenchymal transition, insulin signaling, calcium regulation, cytoplasmic transport, digestion, kidney development, and hypoxia) with no single coherent biological theme tying them together, suggesting the cluster does not reflect a specific, unified function.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001837","count":2},{"id":"GO:0035774","count":2},{"id":"GO:0032869","count":2},{"id":"GO:1901841","count":2},{"id":"GO:0035191","count":2}]},{"hash":"278247353861481417","title":"Unknown","description":"Top GO terms span several unrelated processes (cell division, meiotic chromosome events, antigen processing via MHC, lysosome targeting, vesicle trafficking, plant gravitropism, synaptonemal complex assembly, and neuronal transport), with no clear common function tying the cluster together. Therefore no coherent label can be assigned beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0051307","count":1},{"id":"GO:0048007","count":1},{"id":"GO:0043007","count":1},{"id":"GO:0043323","count":1}]},{"hash":"976048167271401309","title":"Integrin signaling and cell adhesion in skin development","description":"The top GO terms cluster around integrin-mediated signaling and multiple adhesion-related processes (cell-matrix and heterotypic cell-cell adhesion, cellular extravasation) together with skin development and related differentiation, indicating a theme of adhesion-driven signaling guiding skin/tissue organization. Some terms (aging, neuronal ER stress regulation) are less connected but do not override the dominant adhesion/epithelial development signal.","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0045123","count":2}]},{"hash":"2057842704837250292","title":"Cadherin-Driven Adhesion and Developmental Signaling","description":"A cluster with GO terms focused on cell adhesion (homophilic and cadherin-mediated) and developmental processes (synapse assembly, multicellular growth). While immune signaling terms (TLR9 pathway, lipopolysaccharide response) appear, the dominant theme is adhesion-mediated cell\u2013cell interactions guiding development, making this a cohesive adhesion-development cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0034162","count":2},{"id":"GO:0008584","count":2}]},{"hash":"1225363229505164450","title":"Autophagy and Immune Signaling Regulation","description":"Many top terms point to autophagy and inflammatory signaling (autophagy; NF-kappaB-related regulation; IL-17 signaling), plus RNA processing and ubiquitin-dependent protein turnover, suggesting a module centered on cellular stress response linking autophagy with immune signaling. A developmental term appears but likely reflects shared regulatory networks rather than a core function. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0006914","count":4},{"id":"GO:1900458","count":4},{"id":"GO:0072089","count":4},{"id":"GO:2000059","count":4}]},{"hash":"1951090696269635144","title":"Immune signaling and T cell regulation","description":"This set of GO terms is dominated by immune-related functions: negative regulation of TLR9 signaling, negative regulation of T cell receptor signaling, negative regulation of interferon-alpha production, and both positive (granzyme B production, CD8 T cell proliferation) and regulatory aspects of immune activity, suggesting the cluster reflects modulation of innate and adaptive immune responses, particularly T cell activity. A few terms (megakaryocyte development, iron homeostasis) are less directly connected but do not override the central immune-oriented theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034164","count":2},{"id":"GO:0071663","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0061000","count":2},{"id":"GO:0050860","count":2}]},{"hash":"1130922804037782132","title":"Glutathione-Dependent Detoxification","description":"The top terms center on detoxification and glutathione metabolism (glutathione metabolic and derivative biosynthetic processes, cellular oxidant detoxification, xenobiotic catabolic process), suggesting the proteins work together in redox balance and detox pathways; other terms appear incidental rather than defining the cluster.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0035726","count":2},{"id":"GO:1901687","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0009072","count":2}]},{"hash":"652063180141794304","title":"Immune activation and neutrophil recruitment","description":"Dominant terms indicate immune activation and inflammation: positive regulation of T cell proliferation, dendritic cell differentiation, and CD8+ T cell activity; positive regulation of neutrophil extravasation; and modulation of NK cell cytotoxicity, plus endothelial morphogenesis connected to inflammatory responses. A minor development term (trigeminal nerve nucleus development) appears incidental. Overall, the cluster centers on immune cell activation and neutrophil recruitment during inflammation.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001812","count":2},{"id":"GO:2000566","count":2},{"id":"GO:0021740","count":2},{"id":"GO:2001200","count":2},{"id":"GO:1904604","count":2}]},{"hash":"393459567076961692","title":"Unknown","description":"The terms span very different biological areas (epithelial\u2013mesenchymal transition, plant brassinosteroid signaling, mitotic DNA damage checkpoints, chromosome condensation regulation, miRNA processing regulation, calcium detection, lymphangiogenesis, morphine response, and actomyosin ring assembly). They do not converge on a single clear function or pathway, suggesting the cluster is heterogeneous or non-specific. Therefore no confident, representative label can be assigned.","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001837","count":6},{"id":"GO:0009742","count":6},{"id":"GO:0031573","count":6},{"id":"GO:1905213","count":6},{"id":"GO:0051343","count":6}]},{"hash":"142160994698127472","title":"Unknown","description":"The GO terms span calcium signaling, lipid catabolism, post-translational modification, adipocyte and macrophage differentiation, immune regulation, and endocytosis, with no clear cohesive function tying them together, so a specific label isn\u2019t justifiable.","confidence":"","size":6,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0046475","count":3},{"id":"GO:0035508","count":3},{"id":"GO:0070212","count":3},{"id":"GO:0045444","count":3}]},{"hash":"255151551500746181","title":"ER protein folding and secretory pathway","description":"The cluster\u2019s terms emphasize unfolded protein response and ER-associated protein folding, SRP-dependent targeting to the membrane, and secretory pathway-related processes, with insulin secretion regulation reinforcing the secretory context; together they indicate ER quality control and maturation of secreted proteins.","confidence":"High","size":6,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032024","count":2},{"id":"GO:0090084","count":1},{"id":"GO:1903382","count":1},{"id":"GO:0006880","count":1},{"id":"GO:0016226","count":1}]},{"hash":"585073898322986867","title":"Broad-spectrum transmembrane transport","description":"The GO terms cluster around various transmembrane transport processes for ions (potassium), sugars (glucose, galactose, fructose, trehalose), vitamins, and xenobiotics, plus a related osmotic stress response, indicating a group of transport proteins with broad substrate specificity.","confidence":"High","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":6},{"id":"GO:0042908","count":6},{"id":"GO:0035461","count":6},{"id":"GO:0006855","count":6},{"id":"GO:0071332","count":5}]},{"hash":"371964398339824478","title":"Calcium signaling and cytoskeletal contraction","description":"The GO terms cluster around calcium regulatory processes (negative regulation of Ca2+ import, Wnt calcium modulation, regulation of Ca2+ channel activity) and cytoskeletal/contractile functions (diaphragm contraction, actomyosin contractile ring assembly, cytoskeleton-dependent transport). This points to a common theme of calcium-driven signaling coordinating cytoskeletal dynamics and muscle-like contraction, with a few terms that appear less connected (e.g., EMT, digestion) possibly representing unrelated aspects of the proteins. ","confidence":"Medium","size":6,"edges":7,"triangles":4,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090281","count":4},{"id":"GO:0001837","count":3},{"id":"GO:0007223","count":3},{"id":"GO:0035774","count":3},{"id":"GO:1901841","count":3}]},{"hash":"428037706561952127","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":9,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000245","count":1},{"id":"GO:1990141","count":1}]},{"hash":"659778742955394827","title":"Embryonic Organ Development","description":"These proteins are associated with embryonic development and organogenesis across multiple tissues (lung, pituitary, forebrain, hindlimb, placenta, heart, eye, muscle, gonads, prostate), indicating a shared role in broad morphogenetic programs rather than a single pathway.","confidence":"High","size":6,"edges":12,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":4},{"id":"GO:0021983","count":4},{"id":"GO:0021846","count":4},{"id":"GO:0035116","count":4},{"id":"GO:0001890","count":4}]},{"hash":"1080867532595300698","title":"Developmental Cytoskeleton Remodeling and Cell Migration","description":"A cluster with strong representation for actin organization, endocytosis regulation, and mesenchyme migration, paired with development-related processes such as skeletal muscle fiber/muscle adaptation and brain region development. This suggests proteins involved in cytoskeletal remodeling and cell movement during development, with some broader cellular processes also appearing.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043983","count":6},{"id":"GO:0000147","count":6},{"id":"GO:0002121","count":6},{"id":"GO:0030100","count":6},{"id":"GO:0090131","count":6}]},{"hash":"288548047079684655","title":"Developmental signaling and cell division control","description":"The terms point to signaling related to development and tissue remodeling (EMT, lymphangiogenesis) alongside cell cycle regulation (mitotic checkpoint, chromosome condensation), calcium signaling, and various signaling responses (e.g., morphine). The presence of a plant-specific brassinosteroid pathway term alongside animal development terms suggests a broad signaling theme rather than a single precise pathway, but the cohesive thread is signaling processes that govern growth, remodeling, and cell division.","confidence":"Medium","size":6,"edges":7,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001837","count":4},{"id":"GO:0009742","count":4},{"id":"GO:0031573","count":4},{"id":"GO:1905213","count":4},{"id":"GO:0051343","count":4}]},{"hash":"2178636780732926014","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903608","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0071031","count":2}]},{"hash":"2148836738850304354","title":"Diverse Biosynthetic Pathways","description":"The top GO terms cluster around multiple biosynthetic processes (sterol, chlorophyll, biotin, polyamine, resorcinol, daunorubicin) with a few RNA-processing entries (rRNA methylation, ribosomal subunit export), suggesting a broad metabolic and biosynthetic scope rather than a single cohesive function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":3},{"id":"GO:0009877","count":3},{"id":"GO:0019505","count":3},{"id":"GO:1901771","count":3},{"id":"GO:0000056","count":3}]},{"hash":"1260731655888372401","title":"Translation and Translational Regulation","description":"The dominant GO terms all point to protein synthesis and its control\u2014translation mechanics (initiation, elongation, termination, cytoplasmic translation), selenocysteine incorporation, and related mRNA decay\u2014with antibiotic response plausibly linked to ribosome interaction; glial proliferation and cell division likely reflect contexts where translation is upregulated.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0014009","count":2},{"id":"GO:0000288","count":2},{"id":"GO:0001514","count":2}]},{"hash":"1954019883340235708","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034247","count":1},{"id":"GO:0035900","count":1},{"id":"GO:0072684","count":1},{"id":"GO:0016180","count":1},{"id":"GO:0006378","count":1}]},{"hash":"1560035885494416955","title":"Steroid hormone biosynthesis and metabolism","description":"The top GO terms are dominated by biosynthesis and metabolic processes for estrogens, testosterone, glucocorticoids, and other steroids, including both biosynthesis and catabolic directions. This points to a cohesive theme around steroid hormone production and turnover. Some terms like very long-chain fatty acid biosynthesis appear as related lipid pathways, but the core signal remains steroid biosynthesis/metabolism.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0008207","count":2},{"id":"GO:0006703","count":2},{"id":"GO:0042761","count":2},{"id":"GO:0006710","count":2}]},{"hash":"172999789834665790","title":"Vascular development and VEGF signaling","description":"This cluster is dominated by GO terms tied to blood vessel formation and endothelial processes, including positive regulation of angiogenesis, regulation of endothelial tube morphogenesis, and positive regulation of VEGF signaling, plus collagen fibril organization and embryonic development. A few neural terms appear but are likely incidental; the core theme centers on vascular development and VEGF pathway modulation.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":1},{"id":"GO:0021859","count":1},{"id":"GO:0030199","count":1},{"id":"GO:0001701","count":1},{"id":"GO:0006957","count":1}]},{"hash":"1105485763034513324","title":"Embryonic patterning and organogenesis","description":"This cluster shows strong representation of embryonic development and patterning terms (anterior/posterior, proximal/distal patterning, hindbrain and eye development, pancreas and digestive tract formation), suggesting proteins involved in early body plan specification and organogenesis. Some metabolic terms are present but do not dominate; the developmental theme is primary.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051591","count":6},{"id":"GO:0009954","count":6},{"id":"GO:0048566","count":6},{"id":"GO:0030902","count":6},{"id":"GO:0015976","count":6}]},{"hash":"674811019682231125","title":"Neural development and cholinergic signaling","description":"The six proteins share GO terms largely tied to nervous system development and synaptic communication, including axon guidance, retina and Schwann cell development, neuronal-glial interactions, and G protein-coupled acetylcholine signaling, with some outlier terms related to other organ systems. This suggests a cohesive theme around neural development and cholinergic synaptic signaling, albeit with some noise from non-neural developmental terms.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905815","count":1},{"id":"GO:0072249","count":1},{"id":"GO:0043113","count":1},{"id":"GO:0032224","count":1},{"id":"GO:0014044","count":1}]},{"hash":"2066516486181052192","title":"Sensory Neural Development Signaling","description":"This cluster shows enrichment for neural and sensory development terms, including olfactory lobe development and the principal sensory nucleus of the trigeminal nerve, along with BMP signaling. Immune-related terms appear but are less central, so the primary theme is developmental signaling in sensory neural contexts, yielding a Medium confidence.","confidence":"Medium","size":6,"edges":11,"triangles":6,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021740","count":4},{"id":"GO:0002859","count":4},{"id":"GO:1904604","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0033004","count":4}]},{"hash":"1759779641621354106","title":"Nuclear actin dynamics and transcription regulation","description":"The top GO terms combine actin filament regulation and dynamics with RNA polymerase II\u2013related transcription processes (preinitiation complex assembly, transcription regulation, and DNA-templated transcription). This points to proteins that partake in actin remodeling with nuclear roles in transcription or chromatin modulation, possibly actin-related factors involved in Pol II regulation. While one term about neuroblast proliferation is less informative, the dominant pattern suggests an actin\u2013transcription regulatory module.","confidence":"Medium","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042989","count":2},{"id":"GO:0051123","count":1},{"id":"GO:0006357","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0007406","count":1}]},{"hash":"2223471218808106121","title":"Vesicle trafficking and autophagy","description":"This cluster\u2019s top GO terms are dominated by intracellular transport within the secretory/endosomal system (ER to Golgi, early endosome to Golgi) and autophagy, with supporting signals from GTPase activity regulation, suggesting a cohesive role in vesicle movement and autophagic processes. While a few terms point to unrelated biology, the strongest shared theme is vesicle trafficking coupled to autophagy.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006914","count":1},{"id":"GO:0016358","count":1},{"id":"GO:0045212","count":1},{"id":"GO:0034498","count":1}]},{"hash":"185023068468594664","title":"Developmental Morphogenesis and Cell Cycle","description":"The proteins show strong representation of developmental processes (multicellular organism development, skeletal system development, skin development, photoreceptor axon guidance, dendritic spine morphogenesis) alongside cell cycle-related terms (cell division, G1/S transition) and DNA-templated transcription, suggesting a cluster centered on developmental morphogenesis with concurrent roles in cell proliferation. This combination supports the chosen label as representative. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0000082","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0072499","count":2}]},{"hash":"2167140862852267533","title":"Immune signaling regulation","description":"This cluster centers on modulation of immune signaling pathways, with multiple GO terms tied to regulation or dampening of signaling in immune contexts (e.g., negative regulation of IL-2 signaling, TLR9 signaling, p38 MAPK cascade, VEGF/PDGFR signaling) and NK cell\u2013related activity. The combination suggests a set of proteins that fine-tune immune responses and inflammatory signaling, rather than a single isolated pathway, though a few terms (e.g., muramyl dipeptide response) hint at pattern recognition and innate sensing. Overall, the theme is immune signaling regulation.","confidence":"Medium","size":6,"edges":12,"triangles":9,"max_degree":5,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0042267","count":5},{"id":"GO:0030948","count":4},{"id":"GO:1902206","count":3},{"id":"GO:2000646","count":3},{"id":"GO:0060116","count":3}]},{"hash":"1684301664911640473","title":"Developmental and Immune Regulation","description":"The proteins show a mix of developmental processes (stem cell proliferation, embryonic placenta morphogenesis) and broad regulatory/trophic controls (autophagy, ubiquitin-mediated protein turnover, miRNA metabolism), plus immune-related signaling (IL-17 pathway) and antiviral transport/replication regulation. The common thread is general regulatory control of development, gene expression, and host defense, rather than a single specific pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":4},{"id":"GO:1900458","count":4},{"id":"GO:0072089","count":4},{"id":"GO:2000059","count":4},{"id":"GO:0060669","count":4}]},{"hash":"857494353065646367","title":"Unknown","description":"There is no shared GO signal among the proteins (Top Terms is empty) and only one low-connectivity edge, so a coherent functional label cannot be inferred.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"675559732921354248","title":"ER stress and proteostasis","description":"This cluster centers on ER unfolded protein response and proteasomal degradation regulation, suggesting a protein quality-control theme. Additional links to ER-associated misfolded protein handling, Golgi vesicle transport, and energy metabolism (ATP production, aerobic respiration regulation) imply a broad proteostasis/trafficking network with metabolic coordination.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2001171","count":2},{"id":"GO:0071712","count":2},{"id":"GO:1901800","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0048219","count":2}]},{"hash":"1952547128117208237","title":"Proteostasis and cell-cycle stress response","description":"This cluster centers on protein quality control and ER-associated processes (ER unfolded protein response, ERAD, proteasomal degradation, vesicle transport), with supporting hints from protein complex formation and energy regulation. The presence of transcriptional and cell-cycle terms suggests these proteins also participate in broader stress-response signaling that bridges proteostasis with growth and division. Overall, the dominant theme is proteostasis intertwined with stress-responsive regulation and cell-cycle coordination.","confidence":"Medium","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042754","count":2},{"id":"GO:0006351","count":2},{"id":"GO:2001171","count":2}]},{"hash":"1990761423430116869","title":"Unknown","description":"The set of Top Terms is highly diverse, including metabolic biosynthesis (L-arginine, AMP, urate, PRPP), proteolysis, fungal-type cell wall organization, and several development terms (nervous system, bone, organ regeneration). With no edges connecting proteins and no clear common function, there\u2019s no coherent unifying theme to label a specific function for this cluster. Therefore, Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0031505","count":1},{"id":"GO:0006167","count":1},{"id":"GO:0007399","count":1}]},{"hash":"611735029211911346","title":"Unknown","description":"The top GO terms are scattered across carbohydrate biosynthesis (glycogen, sucrose, starch) and lipid/glycan metabolism, plus diverse developmental processes (root hair development, imaginal disc-derived leg segmentation, seed coat mucilage biosynthesis, epithelial polarity maintenance, and Notch signaling-related somitogenesis). This diversity provides no single cohesive function or organism-specific theme to label the cluster.","confidence":"","size":6,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":2},{"id":"GO:0005985","count":2},{"id":"GO:0019252","count":2},{"id":"GO:0046488","count":2},{"id":"GO:0042248","count":2}]},{"hash":"173772890151278236","title":"Ubiquitin-Dependent Translation Initiation and Cell Cycle","description":"The top GO terms show a clear thread around ubiquitin signaling (K11-linked ubiquitination, ubiquitin-dependent ERAD, APC/C-dependent catabolic process) together with translation initiation and preinitiation complex formation, including viral IRES-driven translation. This suggests a functional cluster where ubiquitin-mediated regulation intersects with control of translation initiation and cell-cycle\u2013related proteolysis, despite the absence of network edges in this particular dataset.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0075525","count":2}]},{"hash":"962374224400496256","title":"Ubiquitin-Proteasome Regulation of Mitosis","description":"This cluster is dominated by ubiquitination and proteasome-dependent protein turnover linked to cell cycle control. Terms for SCF-dependent ubiquitination, K11- and K6-linked ubiquitin chains, and G2/M transition point to mitotic regulation, with embryonic development and neuron projection terms likely reflecting broader growth coordination tied to cell cycle progression. Overall, the common theme is ubiquitin-mediated proteolysis driving mitosis.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001701","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0031146","count":6},{"id":"GO:0070979","count":6},{"id":"GO:0000086","count":6}]},{"hash":"2030716995263330801","title":"Cardiac Development and Embryogenesis","description":"The top GO terms concentrate on heart development, cardiac muscle cell proliferation, and embryonic development (in utero), indicating a developmental program focused on heart formation and growth. While other terms touch transcription regulation or immune modulation, the heart/embryogenesis signal is the strongest, justifying this label.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0050728","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0060038","count":3},{"id":"GO:0050796","count":3}]},{"hash":"1058174604946083243","title":"Calcium-Responsive Kinase Signaling","description":"The cluster centers on calcium signaling and regulation of kinase activity, with terms like cellular response to calcium ion, positive regulation of peptidyl-threonine phosphorylation, positive regulation of GTPase activity, and both positive/negative regulation of protein kinase activity suggesting a calcium-dependent signaling module. Some terms (developmental and catabolic processes) are less connected, but the core theme is signaling regulation via calcium and phosphorylation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000272","count":2},{"id":"GO:0071277","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0010800","count":2}]},{"hash":"1318490800271489557","title":"Steroid Hormone Metabolism in Development","description":"These proteins show strong enrichment for steroid-related processes (estrogen, testosterone, androgen, steroid catabolic, very long-chain fatty acid biosynthesis) indicating a core theme of steroid hormone metabolism. The nearby development-related terms (retina development, heart left/right patterning, neuron migration) suggest these steroid pathways intersect with developmental regulation. Together, they point to a cluster centered on steroid hormone metabolism with developmental implications. ","confidence":"Medium","size":6,"edges":12,"triangles":10,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":4},{"id":"GO:0060041","count":3},{"id":"GO:0060971","count":3},{"id":"GO:0001764","count":3},{"id":"GO:0008207","count":3}]},{"hash":"57111752153573669","title":"Neural circadian arousal and locomotion signaling","description":"The top terms converge on circadian sleep/wake regulation, startle and locomotor behavior, and neuromodulator signaling (serotonin and dopamine), supported by neuronal ion transport (potassium and calcium). Sensory pathway development terms (LGN, vestibulocochlear nerve) further point to neural circuit integration. Together these suggest proteins involved in neural circuits governing circadian arousal and movement.","confidence":"High","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045188","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0098703","count":4},{"id":"GO:0001964","count":4},{"id":"GO:0007210","count":3}]},{"hash":"238740098796089587","title":"Neuronal development and synaptic signaling","description":"The terms cluster around brain development, neuronal action potential propagation, and positive regulation of synaptic transmission, with supporting roles for potassium transport and actin-mediated dynamics, all pointing to neuronal development and synaptic function. Some terms (embryo implantation, vasculogenesis, endosome transport) are tangential, but the dominant theme is neuronal development and signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0070830","count":1},{"id":"GO:2001212","count":1},{"id":"GO:0019227","count":1},{"id":"GO:0071805","count":1}]},{"hash":"1892776523621403363","title":"Unknown","description":"The Top Terms span inflammatory signaling (IL-1\u03b2 production, prostaglandin response), blood coagulation, calcium signaling, vascular differentiation, and even sensory/behavioral processes (grooming, phototransduction, appetite). This wide, disparate mix lacks a single coherent function or pathway tying the proteins together, so a meaningful specific label cannot be inferred.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":3},{"id":"GO:0051209","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0007596","count":3},{"id":"GO:2000724","count":3}]},{"hash":"1491598076789353644","title":"Unknown","description":"The GO terms span inflammatory signaling, calcium flux, coagulation, vascular differentiation, viral immune evasion, behavior, vision, appetite, and stress responses with no single cohesive function tying them together, so there is no clear, interpretable cluster theme.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":6},{"id":"GO:0051209","count":6},{"id":"GO:0071380","count":6},{"id":"GO:0007596","count":6},{"id":"GO:2000724","count":6}]},{"hash":"729476396424983484","title":"GCN2-mediated amino acid starvation signaling","description":"The top GO terms center on GCN2-mediated signaling and responses to amino acid starvation (e.g., leucine starvation, regulatory effects on translation initiation), with additional terms indicating broad cellular stress responses (UV-C, oxidative, acidic pH). This suggests a coherent theme around signaling and translational control during nutrient stress, rather than unrelated processes, hence a label focused on GCN2-driven amino acid starvation signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060733","count":1},{"id":"GO:0071494","count":1},{"id":"GO:0071264","count":1},{"id":"GO:0072755","count":1},{"id":"GO:0070301","count":1}]},{"hash":"367737271940297912","title":"Embryonic Organ Development","description":"The top GO terms are dominated by developmental processes across multiple organs\u2014lung alveolus development, embryonic digestive tract development, liver development, and in utero embryonic development\u2014indicating proteins associated with embryogenesis and organ formation. A few terms related to metabolism and stress response appear less connected to this theme and may be secondary. Overall, the cluster most coherently maps to embryonic organ development. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":2},{"id":"GO:0048286","count":1},{"id":"GO:0046111","count":1},{"id":"GO:0048566","count":1},{"id":"GO:0070256","count":1}]},{"hash":"216297357809195105","title":"Vascular and Skeletal Development Signaling","description":"This cluster features SMAD signaling, ERK/MAPK cascade, and regulation of endothelial cell migration, alongside developmental processes for kidney, male gonad, and skeletal system, plus extracellular matrix remodeling via hyaluronan catabolism. Together these terms suggest a shared theme of developmental signaling governing vascular remodeling and organ morphogenesis.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060395","count":2},{"id":"GO:0030214","count":2},{"id":"GO:0043536","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0008584","count":2}]},{"hash":"1150655028469196565","title":"Autophagy-immune regulation cluster","description":"This cluster is dominated by GO terms linking autophagy (GO:0006914), ubiquitination (e.g., K6-linked ubiquitination; ERAD), and immune signaling (T cell proliferation, negative regulation of activated T cell proliferation, NF-kappaB and TNF pathways). Lymph node development also points to immune system involvement. While a neuron-related term (anterograde synaptic vesicle transport) appears, the overall pattern centers on autophagy and ubiquitin-mediated regulation intersecting with immune signaling, particularly T cell modulation and inflammatory pathways. Confidence reflects the plausible, but not exclusive, linking of these processes.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":4},{"id":"GO:0048535","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0042098","count":3},{"id":"GO:0048490","count":3}]},{"hash":"829215211421651806","title":"Unknown","description":"The GO terms span eye morphogenesis, hormone secretion, coagulation, lipid response, signaling regulation, angiogenesis, synapse maintenance, protein oligomerization, brown fat differentiation, and foam cell differentiation, showing no single cohesive function or pathway linking all members.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048593","count":3},{"id":"GO:2000860","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0070543","count":2},{"id":"GO:2000584","count":2}]},{"hash":"1554830917074607272","title":"Triglyceride Catabolism and Phospholipid Remodeling","description":"The top GO terms are dominated by triglyceride catabolic processes and phospholipid catabolic processes (phosphatidylethanolamine and phosphatidylcholine catabolic processes), plus triglyceride mobilization and remodeling, pointing to a lipid metabolism cluster focused on triglyceride breakdown and phospholipid remodeling. Some outliers (defense response, retina formation, PI3K signaling regulation) are present but infrequent and do not define the group.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046338","count":2},{"id":"GO:0010898","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0036153","count":2},{"id":"GO:0006642","count":2}]},{"hash":"1325487945121965965","title":"Neural development and axon guidance","description":"This cluster is driven by GO terms tied to neural development and axon pathfinding, including ephrin receptor signaling, CNS projection neuron axonogenesis, fasciculation of sensory neuron axons, and corpus callosum development, pointing to neural wiring and synaptic connectivity roles. Some terms like axial mesoderm formation and apoptotic process appear ancillary and do not override the main theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048320","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0099557","count":2},{"id":"GO:0060044","count":2},{"id":"GO:0048013","count":2}]},{"hash":"226331077702097281","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902187","count":3},{"id":"GO:0007014","count":3},{"id":"GO:2000637","count":3},{"id":"GO:0061158","count":3},{"id":"GO:0006914","count":2}]},{"hash":"1028106989641532047","title":"Unknown","description":"The GO terms span diverse processes from endocytosis and signaling (pinocytosis, Wnt signaling, calcium release) to lipid metabolism, differentiation (fat cells and foam cells), mechanotransduction, PARylation, and proteasome assembly, with no clear single theme binding the cluster. Therefore no cohesive functional label can be confidently assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048549","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0051209","count":1},{"id":"GO:0046475","count":1},{"id":"GO:0035508","count":1}]},{"hash":"1268036187934258336","title":"Cytoskeleton dynamics and Rho-GTPase signaling","description":"Top GO terms cluster around cytoskeletal organization and signaling, including microtubule localization, GTPase activation, and Rho pathway regulation, with supporting hints from microvillus assembly and related morphogenesis processes. While a few entries touch on development or immune aspects, the core shared function appears to be cytoskeletal dynamics and Rho-mediated signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0019933","count":2},{"id":"GO:0046007","count":2},{"id":"GO:0022007","count":2},{"id":"GO:0090103","count":2}]},{"hash":"1599121520251050659","title":"Ubiquitin-Dependent Protein Degradation","description":"The prominent GO terms cluster around ubiquitin tagging and subsequent proteolysis, including K48- and K63-linked ubiquitination, autoubiquitination, and ubiquitin-dependent protein catabolic processes, indicating a core theme of ubiquitin-mediated degradation; other signals like TNF signaling, histone catabolism, and vitamin D response are less central but may reflect broader regulatory roles.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070936","count":3},{"id":"GO:0085020","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0036205","count":3},{"id":"GO:0042787","count":3}]},{"hash":"421707734178325211","title":"Innate antiviral cytokine signaling","description":"This cluster\u2019s top GO terms are centered on cytokine-mediated signaling and antiviral defense (cytokine-mediated signaling pathway, defense response to virus, innate immune response), pointing to a coordinated role in innate antiviral immunity. A few additional terms touch on transcription regulation and trafficking, but they are less representative of the core function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019221","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0034968","count":1},{"id":"GO:0006355","count":1}]},{"hash":"1836974041313910515","title":"Innate antiviral NF-kappaB signaling and autophagy","description":"The cluster is characterized by multiple GO terms centered on innate immune responses, defense against virus, and positive regulation of canonical NF-kappaB signaling, plus autophagy. This suggests the proteins collectively participate in antiviral innate immunity with NF-kappaB pathway engagement and autophagic processes. Some terms (e.g., plant brassinosteroid signaling, placenta morphogenesis) are less clearly related and may reflect broader GO annotations or cross-species annotations, but the core theme appears to be antiviral immune signaling and autophagy.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035372","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0045087","count":3}]},{"hash":"392595215827616571","title":"Ribosome biogenesis and translation initiation","description":"GO terms clustered around small-subunit processome assembly, eIF4F complex assembly, IRES-dependent translation initiation, and mRNA export, suggesting a shared role in ribosome biogenesis and initiation of translation, with related mRNA processing. This points to a cohesive function in forming ribosomal components and initiating protein synthesis.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0034462","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0097010","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006406","count":3}]},{"hash":"2051586858902453734","title":"Unknown","description":"The GO terms for this cluster span mating projection regulation, vesicle exocytosis, cell migration, organ development, and signaling, with no single cohesive function connecting the members. This diversity makes a meaningful, specific label difficult to justify, so the cluster is best described as Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031384","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0010796","count":3},{"id":"GO:0010762","count":2},{"id":"GO:0035564","count":2}]},{"hash":"1497071509178741700","title":"Planar polarity and tissue morphogenesis","description":"Top terms cluster around planar cell polarity and cell\u2013cell adhesion, including establishment of planar polarity, planar orientation (hair), and homophilic/heterophilic adhesion, with supporting hints from neuronal development (serotonergic axon guidance) and organ morphogenesis (lung branching, mitral valve formation). This suggests the proteins participate in coordinating tissue organization and neural development through planar polarity and adhesion mechanisms.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097150","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0060490","count":2},{"id":"GO:0048105","count":2},{"id":"GO:0002315","count":2}]},{"hash":"1514233438189870830","title":"Regulated Signaling and Receptor Clustering","description":"The cluster\u2019s GO terms center on membrane-associated signaling: receptor clustering and GPCR-mediated acetylcholine signaling, plus several regulatory cues to signaling pathways (negative regulation of BMP signaling, peptidotyrosine phosphorylation). There are also outlying terms related to development and coagulation, suggesting the proteins may participate in broader signaling and cell-surface organization across biological contexts. Overall, the core theme appears to be regulation of signaling and receptor organization, with additional involvement in developmental and hemostatic processes, hence a cautious but reasonable label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0007566","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0007213","count":2}]},{"hash":"840363680912876827","title":"Translation fidelity and tRNA metabolism","description":"The strongest GO terms are regulation of translational fidelity and tRNA metabolic process, which together point to roles in accurate protein synthesis and tRNA handling. The few other terms about obsolete amino acid catabolism are likely noise. With these translation-focused signals dominating, a concise label is Translation fidelity and tRNA metabolism.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006450","count":1},{"id":"GO:1900829","count":1},{"id":"GO:1900832","count":1},{"id":"GO:0006399","count":1}]},{"hash":"1221531257878069575","title":"ER Proteostasis and Quality Control","description":"The cluster centers on endoplasmic reticulum\u2013associated protein folding and quality control (GO:0034975, GO:0030433) and ubiquitin-proteasome\u2013mediated surveillance (GO:0071630), with redox balance (GO:0045454) supporting proteostasis. This suggests a coherent theme of protein maturation, folding, and degradation within cells.","confidence":"Medium","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045454","count":4},{"id":"GO:0097428","count":4},{"id":"GO:0006452","count":4},{"id":"GO:0034975","count":4},{"id":"GO:0030433","count":4}]},{"hash":"539679485955064576","title":"Unknown","description":"There are no GO terms listed for this cluster to guide a functional label, so no coherent theme can be inferred from the provided data. The five proteins and their network connectivity alone do not reveal a shared biological process.","confidence":"","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[]},{"hash":"85436744400103884","title":"Cytoskeleton and cell-adhesion dynamics","description":"The top GO terms point to actin filament organization, lamellipodium assembly, tight junction assembly, and substrate adhesion-dependent cell spreading, all indicative of cytoskeletal remodeling and cell\u2013cell or cell\u2013matrix adhesion processes. While a few terms (e.g., NMDA receptor clustering, parathyroid development) are less directly related, the dominant signal across the cluster is cytoskeletal organization and adhesion dynamics. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":1},{"id":"GO:0007015","count":1},{"id":"GO:0009952","count":1},{"id":"GO:1903760","count":1},{"id":"GO:0030032","count":1}]},{"hash":"1646236959284619642","title":"Mitochondrial Translation and Ribosome Biogenesis","description":"The cluster is dominated by translation-related GO terms (cytosolic translation and mitochondrial translation) and ribosome biogenesis (preribosome assembly, large-subunit assembly). The presence of mitochondrial translation and complex IV assembly terms, along with copper ion homeostasis, suggests a theme around mitochondrial protein synthesis and assembly of the respiratory apparatus, with copper homeostasis supporting respiration. This points to a cohesive function in mitochondrial ribosome function and assembly rather than disparate roles.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0007308","count":1},{"id":"GO:0006825","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0006878","count":1}]},{"hash":"3815832862022624","title":"Membrane dynamics and cell migration","description":"This cluster centers on processes related to cell movement, membrane remodeling, and cytoskeletal changes, including regulation of fibroblast migration, regulation of filopodium assembly, and membrane addition at the cytokinesis site. The presence of terms tied to cell movement and membrane dynamics suggests a cohesive theme around how membranes and the cytoskeleton coordinate cell migration and related processes, despite some auxiliary terms. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010762","count":5},{"id":"GO:0031584","count":5},{"id":"GO:0035564","count":5},{"id":"GO:0051291","count":5},{"id":"GO:0010514","count":5}]},{"hash":"1239254578661222802","title":"Unknown","description":"The proteins in this cluster are linked to a wide range of processes, including interferon immune responses, bone development, endosomal trafficking, insulin-stimulated glucose uptake, neuromuscular/posture control, and neuronal vesicle organization. There is no clear, single biological theme tying these GO terms together, and the lack of edges suggests no strong functional connection among them, so a neutral Unknown label with no confidence is appropriate.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035456","count":2},{"id":"GO:0030282","count":2},{"id":"GO:0099638","count":2},{"id":"GO:0044381","count":2},{"id":"GO:0046597","count":2}]},{"hash":"187100297233346200","title":"Ribosome biogenesis and translation initiation","description":"The top terms center on small-subunit processome assembly, translation initiation (including eIF4F complex and IRES-dependent initiation), and mRNA export, pointing to a role in ribosome biogenesis and the initiation of translation. Despite a few obsolete terms, the shared theme is RNA processing that supports ribosome assembly and protein synthesis rather than regulatory silencing. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0034462","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0097010","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006406","count":3}]},{"hash":"772687613797458639","title":"Developmental signaling and cell adhesion","description":"This cluster centers on growth factor and receptor signaling (PDGF, neurotrophin TRK, integrin pathways) together with cytoskeletal and adhesion-related processes (actin filament dynamics, cell spreading, caveolin-mediated endocytosis, integrin signaling). The presence of heart development and branching morphogenesis terms reinforces a developmental theme, while Fc receptor and B cell differentiation terms indicate signaling contexts in immune cells. Overall, it reflects coordinated signaling and adhesion mechanisms guiding development and cellular interactions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904531","count":3},{"id":"GO:0072584","count":3},{"id":"GO:0010641","count":3},{"id":"GO:0048011","count":3},{"id":"GO:0034446","count":3}]},{"hash":"1832647658619657164","title":"Cell signaling and organelle trafficking","description":"The terms cluster around signaling regulation (insulin response, glucocorticoid signaling, and negative regulation of protein kinase activity) alongside organelle-related processes (vacuolar acidification, proton transport, and Golgi localization). This suggests proteins that couple intracellular signaling with organelle function and trafficking rather than a single linear pathway. While some terms like membrane depolarization and keratinocyte development are more context-specific, they can fit under broader cellular signaling and maturation themes.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":2},{"id":"GO:0015991","count":2},{"id":"GO:0071901","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0042921","count":2}]},{"hash":"1257439568582395725","title":"Leukocyte Activation and Phagocytosis","description":"The top GO terms point to immune-related processes: phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and inflammatory signaling via arachidonate secretion, plus cellular responses to fungal origin. While a couple terms touch development (cartilage condensation, mesonephric duct morphogenesis), the predominant theme centers on leukocyte activation and innate immune responses, suggesting this cluster reflects immune cell\u2013mediated interactions. Confidence: Medium.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":1},{"id":"GO:0006910","count":1},{"id":"GO:0010572","count":1},{"id":"GO:0045575","count":1},{"id":"GO:0050901","count":1}]},{"hash":"2010057451035872011","title":"Chromatin regulation and transcription control","description":"This cluster centers on DNA-templated transcription and chromatin-related processes, including heterochromatin formation, nucleosome density, and chromatin silencing, plus links to cell-cycle regulation. Despite a couple of unrelated terms, the dominant GO terms point to transcriptional control through chromatin state.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000183","count":3},{"id":"GO:0048146","count":2},{"id":"GO:0051726","count":2},{"id":"GO:0036091","count":2}]},{"hash":"38374851010658215","title":"Axon Guidance and Dendrite Development","description":"The top GO terms show strong emphasis on neuronal connectivity, including dendrite development and multiple axon guidance processes (retinal ganglion, commissural, sympathetic). Together with related signaling (ERK cascade) and ECM involvement, this points to neurite outgrowth and axon pathfinding as the cluster's core function.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016358","count":2},{"id":"GO:0060666","count":1},{"id":"GO:0048843","count":1},{"id":"GO:1902336","count":1},{"id":"GO:0071679","count":1}]},{"hash":"329508870715456283","title":"Cardiovascular morphogenesis","description":"The terms cluster around developmental morphogenesis of heart structures and vasculature (aortic valve morphogenesis, ventricular trabecula myocardium morphogenesis, pericardium morphogenesis, endothelial proliferation) and related signaling/mechanical cues (ERK cascade regulation, cellular response to mechanical stimulus). While some items touch on broader developmental processes (germ cell migration, axis specification), the strongest and most consistent theme is heart and vascular development, justifying this label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003180","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0008354","count":2},{"id":"GO:0003222","count":2},{"id":"GO:0001938","count":2}]},{"hash":"1555024959682425088","title":"Negative regulation of ER stress\u2013induced apoptosis","description":"The top GO terms point strongly to suppression of apoptosis triggered by ER stress, including intrinsic and extrinsic pathways, as well as ER calcium homeostasis and unfolded protein response components. This suggests the cluster comprises proteins that help dampen ER-stress\u2013related cell death, with some neuronal context hints (e.g., Purkinje cell differentiation). Overall, a cohesive theme of ER stress\u2013linked apoptosis Regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904721","count":1},{"id":"GO:1902045","count":1},{"id":"GO:0060702","count":1},{"id":"GO:0032469","count":1},{"id":"GO:1902042","count":1}]},{"hash":"1827706595631180117","title":"Ribosome biogenesis and translation initiation","description":"This cluster is dominated by GO terms for ribosome assembly, cytoplasmic translation, and formation of translation preinitiation complexes, plus SRP-dependent cotranslational targeting to membranes. Together they point to the ribosomal machinery and the early stages of protein synthesis, suggesting these proteins function in ribosome biogenesis and translation initiation/targeting. A few other terms (spliceosome regulation, IL-4 response, viral life cycle) appear incidental rather than defining the cluster.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0048025","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1713839924950650784","title":"Diverse solute membrane transporters","description":"The top GO terms show multiple transmembrane transport activities for a range of substrates (nitrite, potassium, phosphate, sialic acid, arabinose, 4-hydroxyphenylacetate, vitamins, etc.), indicating a cluster of membrane transporter proteins with diverse substrate specificities. DNA-templated transcription appears only once and is unlikely to define the group; overall, the dominant function is transport across membranes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0035435","count":1}]},{"hash":"1072358764235269208","title":"Neuronal signaling and membrane dynamics","description":"The most represented terms include regulation of synaptic transmission (GABAergic), regulation of dopamine secretion, IP3 biosynthesis, and protein localization to cortical microtubule cytoskeleton, plus plasma membrane repair. These point to a core theme of signaling control intertwined with membrane and cytoskeletal processes, which fits a neuronal signaling and membrane dynamics label. Some terms about VEGF/immune regulation are peripheral, but the dominant signal is neuronal signaling and membrane/cytoskeleton regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":3},{"id":"GO:0060313","count":2},{"id":"GO:1904468","count":2},{"id":"GO:0072699","count":2},{"id":"GO:0032228","count":2}]},{"hash":"361079080153318961","title":"Neural development and axonogenesis","description":"This cluster is labeled Neural development and axonogenesis because the top GO terms predominantly point to nervous system development and axon-related processes, including optic nerve morphogenesis, central nervous system projection neuron axonogenesis, fasciculation of sensory neuron axons, vestibular receptor cell morphogenesis, and photoreceptor differentiation. A few terms reference broader morphogenesis or non-neural tissues (e.g., pericyte and nephric duct morphogenesis), but the strongest and most recurrent signals describe neural development and axon pathfinding.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":3},{"id":"GO:1902960","count":3},{"id":"GO:0001751","count":3},{"id":"GO:1904238","count":3},{"id":"GO:0021631","count":3}]},{"hash":"583993692578294979","title":"Developmental processes","description":"The top GO terms are dominated by developmental processes across multiple tissues (nipple morphogenesis, lung connective tissue development, metanephric glomerulus development, caudal fin development, notochord cell vacuolation), suggesting a theme of organismal development. A few inflammatory and cellular housekeeping terms appear but are outnumbered by development-related terms, so the cluster likely reflects developmental pathways rather than a single tissue-specific function. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0072224","count":2},{"id":"GO:0007035","count":1}]},{"hash":"1265062227343020022","title":"Neuronal Excitability and Neurotransmission","description":"The cluster\u2019s terms cluster around ion channel activity and membrane depolarization (potassium and sodium transport) and excitatory postsynaptic potential, core aspects of neuronal signaling. Additional terms involve dopamine and serotonin signaling, linking to neuromodulation and heart-rate regulation via baroreceptor responses, plus development and function of sensory pathways (vestibulocochlear nerve, lateral geniculate nucleus) and sound detection, pointing to broader sensory processing. Together, they suggest a cohesive theme of neuronal excitability, neurotransmission, and sensory processing.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0051899","count":5},{"id":"GO:0050910","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0060079","count":5}]},{"hash":"831757903675035936","title":"Meiotic Chromosome Segregation","description":"The top GO terms are strongly centered on meiosis-related chromosome handling: chromosome segregation, meiotic spindle midzone assembly, and sister chromatid cohesion in male meiosis. While there are some apoptosis and signaling terms present, they are less representative of the main function. Thus, labeling the cluster as Meiotic Chromosome Segregation reflects the dominant theme among the annotated functions.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007059","count":1},{"id":"GO:0051257","count":1},{"id":"GO:0007065","count":1},{"id":"GO:0001808","count":1},{"id":"GO:0071380","count":1}]},{"hash":"812950471940050160","title":"DNA replication and telomere maintenance","description":"Most represented GO terms point to genome maintenance: DNA replication, DNA unwinding, telomere capping, and localization to telomeric regions, with supporting DNA repair activity. A few terms (Wnt signaling, insulin response, development) are less central and likely incidental. Overall, the cluster centers on replication-associated and telomere-related processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006268","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0016055","count":1},{"id":"GO:0043504","count":1},{"id":"GO:1904355","count":1}]},{"hash":"2148862904227565485","title":"Extrinsic Apoptosis Signaling and Immune Regulation","description":"Predominant GO terms point to extrinsic apoptotic signaling and the execution phase, with supporting associations to immune processes such as thymus development, T cell selection, B cell proliferation regulation, and an LPS response. This pattern suggests a cohesive cluster of proteins involved in stress-induced apoptosis intertwined with immune development and regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097194","count":2},{"id":"GO:0000077","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0048538","count":2}]},{"hash":"721725169914950029","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030970","count":1},{"id":"GO:0010936","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0097051","count":1},{"id":"GO:0036010","count":1}]},{"hash":"237369114529539537","title":"Heart development and erythrocyte/megakaryocyte differentiation","description":"The top GO terms cluster around developmental processes in the heart (endocardial cushion development, aortic valve morphogenesis, cardioblast fate, cardiac muscle regeneration) and hematopoietic differentiation (erythrocyte and megakaryocyte differentiation). This suggests the proteins collectively relate to both cardiovascular development and blood cell lineage differentiation, rather than a single narrow function. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010725","count":2},{"id":"GO:0045648","count":2},{"id":"GO:0045654","count":2},{"id":"GO:0061026","count":1},{"id":"GO:0007510","count":1}]},{"hash":"1015108920831054734","title":"Unknown","description":"The GO terms span very diverse processes across different species (nematode pharyngeal pumping, chitin-based cuticle/molting, reproduction and polyspermy, fin morphogenesis, immune/inflammatory signaling, metabolism, and proteolysis), with no clear, cohesive theme tying them together into a single functional cluster. This lack of a unifying function makes a reliable specific label inappropriate.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0006032","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0043050","count":1}]},{"hash":"47281321896314268","title":"Embryonic neural and skeletal development","description":"The GO terms point to broad embryonic development across tissues (cranial skeleton morphogenesis, hindbrain rhombomere development, motor neuron and muscle differentiation, eye and organ development), suggesting involvement in early embryogenesis and patterning rather than a single pathway.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":4},{"id":"GO:0021524","count":3},{"id":"GO:0098528","count":3},{"id":"GO:0043010","count":3},{"id":"GO:0021570","count":3}]},{"hash":"1780454766722966019","title":"Unknown","description":"The GO terms cover a wide and disparate set of processes (calcium signaling, plant stomatal closure, ERBB2/mammalian signaling, neuronal dendrite extension, insulin response, and redox/glutathione biosynthesis) with no clear, single biological theme connecting them. The absence of shared pathways and no interactions among proteins further suggest a heterogeneous cluster rather than a coherent functional group.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060548","count":1},{"id":"GO:0071277","count":1},{"id":"GO:0090332","count":1},{"id":"GO:1903861","count":1},{"id":"GO:0080148","count":1}]},{"hash":"1227057863816582601","title":"Steroid-regulated Embryonic Development","description":"The cluster includes developmental processes such as retina development, embryonic heart tube left/right patterning, and neuron migration, alongside multiple steroid hormone biosynthesis/metabolism terms. This suggests a theme where steroid pathways influence embryonic development and patterning, leading to a cohesive, though broad, developmental-steroid connection.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0060971","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0008207","count":1},{"id":"GO:0006703","count":1}]},{"hash":"455563206124780801","title":"Cell Junctions and Signaling","description":"The cluster shows enrichment for junction assembly terms (paranodal and septate junctions), suggesting a core theme around cell-cell junction formation. It also includes signaling-related terms (Notch, integrin, NF-kappaB) and mechanosensory detection, indicating a cohesive, junction-linked signaling/mechanotransduction theme, despite low connectivity among proteins.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":2},{"id":"GO:0050910","count":2},{"id":"GO:2000145","count":1},{"id":"GO:1901223","count":1},{"id":"GO:2001046","count":1}]},{"hash":"2092172231538080158","title":"Innate antiviral defense and ubiquitin-regulated apoptosis","description":"This cluster centers on antiviral innate immunity (defense response to virus, innate immune response, regulation of TLR signaling) and on programmed cell death control (apoptosis and necroptosis), with a notable emphasis on ubiquitination processes (protein polyubiquitination, histone ubiquitination). The lack of edges does not diminish the functional coherence around immune signaling and apoptosis regulation. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0060544","count":2}]},{"hash":"2069012911955882504","title":"Dendritic Spine Morphogenesis and Rac Signaling","description":"The top GO terms cluster around actin-driven remodeling pertinent to neuronal synapses\u2014lamellipodium/ruffle assembly, Rac signaling, and especially dendritic spine development and morphogenesis (with hippocampus-related terms). While a few terms touch on general trafficking and oligomerization, the dominant signal is Rac-regulated spine remodeling and neuronal spine morphogenesis.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":2},{"id":"GO:0045792","count":2},{"id":"GO:0010592","count":2},{"id":"GO:0097178","count":2},{"id":"GO:0032966","count":2}]},{"hash":"494860192330515200","title":"Spliceosome and RNA Processing","description":"The top GO terms are dominated by mRNA splicing via the spliceosome (GO:0000398) and spliceosomal snRNP assembly (GO:0000387), with an additional RNA maturation term for rRNA processing (GO:0000463). This constellation points to a cluster of proteins involved in RNA processing and splicing machinery, with some incidental cell-cycle or apoptotic regulation signals. The emphasis on spliceosome-related functions supports this concise label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0043066","count":1},{"id":"GO:0007049","count":1},{"id":"GO:2000825","count":1},{"id":"GO:0000387","count":1}]},{"hash":"490151222302499194","title":"Specialized autophagy: nucleophagy and glycophagy","description":"The top GO terms point to autophagy-related processes: autophagosome assembly, targeting to vacuoles in autophagy, and specific forms like nucleophagy and glycophagy, along with piecemeal microautophagy of the nucleus. Stress-response terms (hydrogen peroxide, metal exposure) also connect to autophagy induction. Taken together, these proteins likely participate in selective autophagy pathways and organelle turnover.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035096","count":2},{"id":"GO:0071211","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0010288","count":2},{"id":"GO:0000045","count":2}]},{"hash":"1643168407899349958","title":"Mitotic spindle assembly and checkpoint","description":"This cluster\u2019s top GO terms are centered on mitosis-related processes: attachment of spindle microtubules to kinetochores, spindle organization, centrosome separation, and spindle assembly/checkpoint signaling. While a few terms hint at broader signaling pathways (phorbol ester response, neurotrophin signaling, growth regulation), the dominant theme is mitotic spindle dynamics and checkpoint control.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0051316","count":5},{"id":"GO:0000189","count":5},{"id":"GO:0007070","count":5},{"id":"GO:0007100","count":5},{"id":"GO:1904628","count":5}]},{"hash":"1755180242167120850","title":"Mitotic Spindle & Checkpoint Signaling","description":"The cluster is dominated by GO terms tied to mitotic spindle dynamics (spindle organization, kinetochore attachment, centrosome separation) and mitotic/dna damage checkpoint signaling, indicating a cohesive role in mitosis regulation. A couple of older or broader terms appear but do not outweigh the spindle-centric theme.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0051316","count":4},{"id":"GO:0000189","count":4},{"id":"GO:0007070","count":4},{"id":"GO:0007100","count":4},{"id":"GO:1904628","count":4}]},{"hash":"344281706866303979","title":"Unknown","description":"The cluster's top GO terms span inflammatory signaling (IL-1\u03b2 production), calcium release, prostaglandin response, blood coagulation, and vascular differentiation, yet also include behavioral/sensory terms (grooming, phototransduction, appetite). These functions do not converge on a single clear biological theme, making a specific, representative label difficult; thus Unknown.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032651","count":5},{"id":"GO:0051209","count":5},{"id":"GO:0071380","count":5},{"id":"GO:0007596","count":5},{"id":"GO:2000724","count":5}]},{"hash":"1563864800549725406","title":"Axon growth and ECM signaling","description":"This cluster centers on integrin and ephrin signaling, Wnt pathway regulation, and extracellular matrix remodeling (hyaluronan metabolism and metallopeptidase activity), all of which point to neuronal axon guidance and growth through cell\u2013ECM adhesion and signaling. The presence of ubiquitination also suggests regulation of protein turnover within this pathway. The single edge and no triangles indicate these terms reflect a broader functional theme rather than a tightly connected protein complex.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0045071","count":3},{"id":"GO:0030212","count":3},{"id":"GO:1905050","count":3}]},{"hash":"54771428907841602","title":"Actin Cytoskeleton Regulation and Microvilli Dynamics","description":"The GO terms cluster around actin filament dynamics (severing, capping), cytoskeleton-driven cell motility, and regulation of microvillus length and membrane organization, suggesting an actin-based control of microvilli and associated membrane domains.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032532","count":1},{"id":"GO:1990000","count":1},{"id":"GO:1903906","count":1},{"id":"GO:0060327","count":1},{"id":"GO:0061156","count":1}]},{"hash":"334844240606887864","title":"Axon guidance and neural development","description":"Based on the prominent nervous system terms (nervous system development; axon guidance; Roundabout signaling pathway) and supporting neuronal signaling cascades (JNK/ERK), the cluster appears to center on neural development and axonal pathfinding. While there are a few immune-related terms in the list, the strongest cohesive theme is neural development and axon guidance, with signaling pathways that can also operate in neurons. Confidence in this thematic label is moderate due to the mixed immune-related terms.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":3},{"id":"GO:0042088","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0032707","count":3},{"id":"GO:0035385","count":3}]},{"hash":"543076543586279983","title":"Mitochondrial stress signaling and apoptosis","description":"The top GO terms cluster around mitochondrial processes (mitochondrial outer membrane permeabilization, ER stress\u2013induced apoptotic signaling), stress-related kinase pathways (JNK cascade, protein kinase regulation), and trafficking/secretion (exosomal release, endosome-to-Golgi transport), together with regulation of cell migration. This suggests a cohesive theme of cellular stress sensing and signaling involving mitochondria that modulates survival, migration, and intercellular communication.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010762","count":3},{"id":"GO:0048312","count":3},{"id":"GO:1990182","count":3},{"id":"GO:0090051","count":3},{"id":"GO:0090334","count":3}]},{"hash":"1911559242326586122","title":"NF-kappaB-driven inflammation and cytokine regulation","description":"The proteins show strong representation of NF-kappaB signaling and cytokine (IL-6) production, along with regulation of TLR pathways and ubiquitin-related processes, pointing to an immune/inflammatory module where NF-kappaB controls cytokine responses and protein turnover of signaling components.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":3},{"id":"GO:0045410","count":2},{"id":"GO:0090073","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0000209","count":2}]},{"hash":"1381266451722080263","title":"Mitotic spindle and checkpoint control","description":"The Top Terms cluster centers on mitotic spindle dynamics (attachment to kinetochores, spindle organization, centrosome separation) and checkpoint signaling (mitotic and G1 DNA damage checkpoints), indicating a coherent theme of mitosis and cell-cycle control. Some unrelated terms appear, but the dominant signal is spindle function and chromosome segregation during cell division. ","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0051316","count":5},{"id":"GO:0000189","count":5},{"id":"GO:0007070","count":5},{"id":"GO:0007100","count":5},{"id":"GO:1904628","count":5}]},{"hash":"1634090740883135641","title":"Unknown","description":"This cluster includes GO terms across diverse pathways\u2014mycothiol biosynthesis (bacterial redox cofactor), angiogenesis, multiple acetylation events (peptidyl and histone acetylation), glucosamine and arginine biosynthesis, and melatonin biosynthesis\u2014along with several obsolete terms. The lack of a common, cohesive function across these terms suggests annotation noise rather than a single biological theme. Therefore I cannot assign a meaningful, specific label.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0060358","count":3},{"id":"GO:0017198","count":3},{"id":"GO:0006041","count":3}]},{"hash":"535880568802486776","title":"Neuronal and Cardiac Development","description":"The cluster is enriched for neural differentiation terms (midbrain dopaminergic neuron differentiation, cerebellar Purkinje cell precursor signaling, visceral motor neuron differentiation, medial motor column neuron differentiation) and includes atrial cardiac muscle cell development, suggesting a shared theme around development of neural and cardiac lineages; a few peripheral terms (gonad development, prostaglandin biosynthesis, platelet aggregation, and fungal cell wall regulation) appear as lesser contributors.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":2},{"id":"GO:0070527","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0055014","count":1},{"id":"GO:0021524","count":1}]},{"hash":"1241527373728897654","title":"Transmembrane transporters (nutrients and xenobiotics)","description":"The top GO terms are dominated by various transmembrane transport processes (vitamin, xenobiotic, daunorubicin, monoatomic anion, and methionine transport), suggesting a cluster of membrane transporter proteins. A few outlier terms (antigen processing via MHC I, nodulation, plant vascular patterning) may reflect annotation noise or multi-function proteins, but the central theme is transport across membranes for nutrients and xenobiotics.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0019885","count":2},{"id":"GO:0009877","count":2}]},{"hash":"17111680851899647","title":"Transcriptional Regulation and Differentiation Control","description":"This cluster is enriched for transcription-related terms (DNA-templated transcription, regulation of transcription) and multiple entries about negative regulation of differentiation across several lineages (osteoblast, astrocyte, pancreatic cells), with an epigenetic hint from histone deacetylation. Although other terms like circadian heart rate and xenobiotic response are present, the core signal points to transcriptional/epigenetic control of cell fate decisions.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":5},{"id":"GO:0060766","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0070932","count":3},{"id":"GO:0006355","count":3}]},{"hash":"212095485958530560","title":"ER protein quality control and membrane trafficking","description":"This cluster is dominated by GO terms related to endoplasmic reticulum (ER) protein handling: ERAD maintenance of unfolded proteins, ER-associated degradation pathways, ER stress negative regulation, and tail-anchored membrane protein insertion into the ER membrane, along with deglycosylation and sumoylation processes. These point to a cohesive theme of ER protein folding/quality control and trafficking, despite a few noisy or unrelated terms present.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1904378","count":3},{"id":"GO:0071816","count":2},{"id":"GO:0006517","count":2},{"id":"GO:1902236","count":2},{"id":"GO:0000028","count":2}]},{"hash":"179632522764847920","title":"Nucleoside Transport & Ribosome Biogenesis","description":"The cluster shows clear signals for nucleoside transport (cytidine, purine, and pyrimidine nucleoside transport) and ribosome biogenesis (small subunit biogenesis and ribosome biogenesis), suggesting a theme around supplying nucleotides for RNA synthesis and ribosome assembly, essential for cell growth. Some other terms (cell division, stress response) may reflect broader growth regulation, but the core link is nucleotide transport with ribosome production.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015861","count":1},{"id":"GO:0015860","count":1},{"id":"GO:0015864","count":1},{"id":"GO:0055072","count":1},{"id":"GO:0051301","count":1}]},{"hash":"811987922403436661","title":"tRNA aminoacylation and translation (mitochondrial)","description":"The top GO terms center on aminoacyl-tRNA synthetase activities (lysyl-, aspartyl-, asparaginyl-, etc.), general translation, and tRNA wobble modification, with clear emphasis on mitochondrial tRNA charging. This points to a cohesive function in tRNA aminoacylation and ribosome-driven protein synthesis, particularly in mitochondria; a few telomere/DNA recombination terms may reflect secondary roles or annotation noise.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006422","count":4},{"id":"GO:0010833","count":4},{"id":"GO:0070154","count":4},{"id":"GO:0006310","count":4}]},{"hash":"342504526538594758","title":"Neural development and ECM remodeling","description":"This cluster centers on neural development processes\u2014such as neural tube formation, somitogenesis, spinal cord association neuron specification, and dendrite regeneration\u2014alongside extracellular matrix (ECM) dynamics like hyaluronan metabolism and ECM assembly regulation, plus cell adhesion/extravasation terms. The combination suggests a theme of morphogenesis in neural tissues coupled with ECM remodeling and cell\u2013cell interactions. Some immune-related terms (complement activation, coagulation) may reflect broader vascular or developmental contexts rather than a single pathway. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001756","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0030212","count":2},{"id":"GO:0045123","count":2},{"id":"GO:0034113","count":2}]},{"hash":"1253338332307875941","title":"Membrane trafficking and signaling","description":"The proteins appear to cluster around membrane dynamics and signaling: synaptic vesicle exocytosis, clathrin-dependent endocytosis, membrane tubulation, and filopodium regulation point to vesicle trafficking and cytoskeletal coordination, while GPCR signaling and cell adhesion/migration suggest membrane-associated signaling and interactions. Some GO terms are obsolete or metabolic (insulin/glucose import), which may reflect annotation noise rather than a core function, but the prevailing theme is membrane trafficking intertwined with signaling and cytoskeletal dynamics.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0007155","count":2},{"id":"GO:0097473","count":2}]},{"hash":"2019834989347561516","title":"Developmental Morphogenesis and Patterning","description":"The top terms cluster around embryonic development and tissue morphogenesis across multiple organs (mesoderm development, left/right patterning, cartilage and hair follicle morphogenesis, palate development), suggesting a shared theme of developmental patterning rather than a single pathway. A noisy item about heat-stress transcription is present but does not override the overarching developmental signal.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061408","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0007498","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0031069","count":1}]},{"hash":"853829950842309772","title":"Unknown","description":"No shared GO terms are provided, and the small cluster with 5 proteins and only 2 edges shows no clear common function to label.","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"716764051630973622","title":"Redox homeostasis and detoxification","description":"Dominant GO terms cluster around redox balance and detoxification (cell redox homeostasis; cellular oxidant detoxification; glutathione derivative biosynthetic process; xenobiotic catabolic process; response to L-ascorbic acid), with prostaglandin biosynthesis and insulin response as related signals; overall this suggests a group of proteins involved in managing oxidative stress and detoxifying harmful compounds.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0035726","count":1},{"id":"GO:1901687","count":1}]},{"hash":"1101798865804600268","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070671","count":2},{"id":"GO:0070935","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0030212","count":2},{"id":"GO:1905050","count":2}]},{"hash":"1677774511706478109","title":"Mitotic spindle organization and cell cycle control","description":"The top terms concentrate on mitotic spindle organization, centrosome separation, and checkpoint signaling, pointing to a role in mitosis and cell cycle progression; a glucose metabolic process and a PMA-responsive signaling term appear, likely reflecting broader cellular functions captured in the cluster, but the dominant pattern supports a mitosis-focused cluster.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":3},{"id":"GO:0051316","count":2},{"id":"GO:0000189","count":2},{"id":"GO:0007070","count":2},{"id":"GO:0007100","count":2}]},{"hash":"1475072669858420408","title":"Broad-Substrate Membrane Transporters","description":"Top GO terms describe transmembrane transport of diverse substrates (xenobiotics, sugars, ions, vitamins, etc.), indicating these proteins function as broad-specificity membrane transporters rather than a single-substrate transporter.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0035435","count":1},{"id":"GO:0015739","count":1}]},{"hash":"1511309151106443724","title":"Neuronal development and synapse maturation","description":"The strongest signals are neuronal-focused: cerebellar Purkinje cell layer development, synapse maturation, and adhesion terms (heterophilic cell-cell adhesion, cell-matrix adhesion) point to neuronal wiring and synapse formation, supported by PKC signaling regulation in neuronal contexts. The other terms (thyroid hormone generation, single fertilization, complement activation, phagolysosome assembly) are less related to this theme and may reflect broader multi-function annotations or context-specific roles. Overall, the core functions align with neuronal development and synaptic connectivity.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006590","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0021680","count":4},{"id":"GO:0090036","count":4},{"id":"GO:0007157","count":4}]},{"hash":"437142217114394503","title":"Mitochondrial Metabolite Transport and Fission","description":"The cluster is dominated by GO terms for transport of nucleotides and metabolites across mitochondrial membranes (pyrimidine import, ADP/NAD/citrate transport, malate-aspartate shuttle) and includes mitochondrial membrane fission, with additional notes on insulin/IGF-related metabolic signaling. This combination points to a cohesive theme of mitochondrial metabolite exchange and dynamics, rather than a single, unrelated function.","confidence":"High","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":4},{"id":"GO:0000066","count":4},{"id":"GO:0043490","count":4},{"id":"GO:0090149","count":4},{"id":"GO:0032869","count":4}]},{"hash":"2241788309022934902","title":"Embryonic development and morphogenesis","description":"These GO terms cluster around developmental processes across multiple tissues, including left/right patterning, mesoderm formation, cartilage morphogenesis, placenta-related differentiation, hair follicle morphogenesis, endocardial cushion EMT, and endocrine system development. The common thread is embryonic development and tissue morphogenesis rather than a single pathway, justifying a general development/morphogenesis label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060707","count":2}]},{"hash":"1431147495422577728","title":"Neurodevelopment and synaptic signaling","description":"This cluster's top GO terms are centered on nervous system development and neuronal function, including axonogenesis, Schwann cell development, excitatory postsynaptic potentials, and visual perception. While there are also terms like heart development, the strongest signal is neural development and synaptic activity, justifying a neurofocused label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0008284","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0043065","count":2}]},{"hash":"1760101334675908569","title":"Unknown","description":"The top GO terms are highly diverse, spanning rRNA maturation, histone methylation, cell cycle regulation, viral mRNA export, defense against bacteria, hypoxia response, TGF-beta signaling, and ubiquitin-mediated ERAD. There is no single cohesive biological function or pathway linking these terms, and the cluster shows no edges or strong connections, so a meaningful specific label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0060770","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0046784","count":2}]},{"hash":"1963638372822786406","title":"Aminoacyl-tRNA Synthetases","description":"Top terms are dominated by multiple aminoacyl-tRNA synthetase activities (cysteinyl-, leucyl-, methionyl-, isoleucyl-, valyl-tRNA aminoacylation) and translation, pointing to a cluster of tRNA charging enzymes essential for protein synthesis, with a minor outlier term likely incidental.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006423","count":1},{"id":"GO:0010125","count":1},{"id":"GO:0006450","count":1},{"id":"GO:0006429","count":1},{"id":"GO:0006431","count":1}]},{"hash":"864556626523850736","title":"Embryonic Neural Development and Synaptic Assembly","description":"This cluster features GO terms tied to embryonic development (in utero embryonic development and parturition) and neural communication structures (postsynaptic membrane assembly and presynaptic membrane organization), indicating a focus on neural development and synapse formation during early development. Although there are also terms related to angiogenesis and complement activation, the dominant pattern points to embryonic/neural maturation and synaptic assembly, justifying the name.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":1},{"id":"GO:1902960","count":1},{"id":"GO:0007567","count":1},{"id":"GO:0097104","count":1},{"id":"GO:0001701","count":1}]},{"hash":"428041959457734700","title":"Tubule and lymphatic morphogenesis","description":"This cluster is driven by repeated terms for kidney tubule development/morphogenesis and lymph vessel morphogenesis, indicating a morphogenesis-focused theme across renal and lymphatic systems. The remaining terms occur only once and seem incidental to this primary pattern.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072237","count":2},{"id":"GO:0072287","count":2},{"id":"GO:0036303","count":2},{"id":"GO:0032497","count":1},{"id":"GO:0002730","count":1}]},{"hash":"1602278731036775524","title":"mRNA capping and cap methylation","description":"The GO terms point to the core process of 7-methylguanosine mRNA capping and the recruitment of the capping enzyme to RNA polymerase II, along with methylation of the cap. This suggests the cluster comprises proteins involved in co-transcriptional mRNA capping and cap modification; the limited terms indicate a focused RNA processing function.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":1},{"id":"GO:0036031","count":1},{"id":"GO:0032259","count":1}]},{"hash":"960804580170934420","title":"Unknown","description":"The GO terms are very diverse and do not point to a single shared function or pathway for these four proteins; only one term relates to mitochondria distribution and others span development, signaling, and cellular processes, with no interactions (edges) among them. This suggests no cohesive functional theme for the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048312","count":2},{"id":"GO:1901001","count":1},{"id":"GO:0010762","count":1},{"id":"GO:0031584","count":1},{"id":"GO:0035564","count":1}]},{"hash":"240500045590664425","title":"Photostress Response and Lens Development","description":"The GO terms clustered here are dominated by light/heat stress responses (response to UV-A, response to high light intensity, regulation of cellular response to heat, stress-activated MAPK cascade) and a specific annotation for lens fiber cell morphogenesis, suggesting a cohesive theme around photic stress handling and eye lens development. Some terms (e.g., muscle contraction, intracellular transport) are less directly connected, but the strongest pattern supports a label centered on photic stress response with lens development context.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070141","count":2},{"id":"GO:1900034","count":2},{"id":"GO:1905907","count":2},{"id":"GO:0009644","count":2},{"id":"GO:0006936","count":2}]},{"hash":"615361386589583330","title":"Developmental signaling and morphogenesis","description":"The top terms include Hedgehog (smoothened) signaling, ROBO (Roundabout) signaling, and T cell receptor signaling, along with kidney and nervous system development and regulation of morphogenetic processes. This pattern suggests a group of proteins involved in developmental signaling networks governing organogenesis and tissue patterning across multiple systems.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0007399","count":3}]},{"hash":"2005626516507488533","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006858","count":1},{"id":"GO:0006897","count":1},{"id":"GO:0072356","count":1},{"id":"GO:0001881","count":1}]},{"hash":"1742931973325933766","title":"Translation Machinery and Ribosome Biogenesis","description":"The proteins are enriched for translation-related GO terms (translation, translational termination) and ribosome assembly (ribosomal large subunit biogenesis), suggesting a focus on protein synthesis and ribosome biogenesis. Some transcription-related terms are present but far less representative, so the dominant theme is translation machinery.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006415","count":2},{"id":"GO:0042273","count":1},{"id":"GO:0031564","count":1},{"id":"GO:1902164","count":1}]},{"hash":"1147711202256370893","title":"DNA transposition and proviral integration","description":"The top GO terms cluster around DNA mobility: transposition and integration (DNA transposition, DNA integration, proviral latency), with supporting signals from chromosome segregation and cell cycle terms. This suggests a theme centered on mobile genetic elements and proviral integration, rather than a single classical cellular pathway. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0007059","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1071419390208887346","title":"Neural development and ECM remodeling","description":"The cluster's top GO terms indicate a focus on neural development (astrocyte development, axon fasciculation, neuron remodeling) alongside broader vertebrate development (somite, hair follicle, system development). It also features extracellular matrix remodeling and cell adhesion processes (ECM disassembly, substrate adhesion-dependent spreading, heterophilic cell-cell adhesion). Together these terms suggest a module of proteins involved in developmental tissue formation with a particular emphasis on neural patterning and ECM-mediated cell interactions.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"wound healing","top_go_terms":[{"id":"GO:0014002","count":4},{"id":"GO:0097155","count":4},{"id":"GO:0016322","count":4},{"id":"GO:0001942","count":4},{"id":"GO:0048731","count":4}]},{"hash":"466050001378584318","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000463","count":3},{"id":"GO:1903608","count":3},{"id":"GO:0001111","count":3},{"id":"GO:0045003","count":3},{"id":"GO:0070870","count":3}]},{"hash":"1089742876787754473","title":"Unknown","description":"The top GO terms span diverse, mostly unrelated processes (DNA-templated transcription, rRNA maturation, histone methylation) and include stress/immune responses (hypoxia, TGF-beta signaling, defense against Gram-positive bacteria) as well as viral mRNA export. With no interactions among members and no clear unifying function, there isn\u2019t a coherent label to assign beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0060770","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0000747","count":2}]},{"hash":"1383140004924442098","title":"Dopaminergic Synaptic Transmission and Drug Response","description":"The terms show a clear emphasis on brain signaling and drug-related processes: dopaminergic synaptic transmission, morphine and cocaine responses, sensory pain perception, visual learning, and MAPK/ERK signaling in neurons. While there is one term related to macrophage chemotaxis, many entries point to neural communication and behavioral responses, supporting a label centered on neuronal signaling and drug responsiveness rather than immune function.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010759","count":4},{"id":"GO:0071380","count":4},{"id":"GO:0006468","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0008542","count":4}]},{"hash":"997716082347418097","title":"Ribosome biogenesis and translation","description":"The cluster centers on translation machinery and ribosome assembly, including translation, initiation complex and small-subunit processome assembly, plus mRNA export and regulation of translational initiation, indicating a cohesive theme of ribosome biogenesis and protein synthesis with a minor outlier in mitochondrial function.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006120","count":1},{"id":"GO:0034462","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0097010","count":1}]},{"hash":"968937503553607861","title":"Unknown","description":"The listed GO terms cover apoptosis, prostaglandin signaling, platelet activation, cytoskeletal remodeling, and a few unrelated processes, with no edges connecting the proteins. This makes it difficult to identify a single coherent function for the cluster, so a generic Unknown label is appropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":1},{"id":"GO:0060313","count":1},{"id":"GO:0010572","count":1},{"id":"GO:0097194","count":1},{"id":"GO:0008637","count":1}]},{"hash":"858449551442313383","title":"DNA repair and telomere maintenance","description":"The cluster\u2019s GO terms predominantly relate to genome integrity: DSB repair via nonhomologous end joining, interstrand cross-link repair, telomere maintenance and telomeric loop formation, and responses to DNA-damaging stimuli (X-ray, bleomycin). While seed development/germination and B cell differentiation appear in the list, they seem peripheral or reflective of broader recombination processes; the central theme is DNA damage response and telomere biology.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048316","count":1},{"id":"GO:0010833","count":1},{"id":"GO:2000685","count":1},{"id":"GO:1904975","count":1},{"id":"GO:0009845","count":1}]},{"hash":"500014866532661880","title":"RNA metabolism and translation under stress","description":"These proteins show links to RNA processing/export (mRNA export from nucleus; small-subunit processome), ribosome assembly, and translation control (eIF4F complex assembly; IRES-dependent initiation; translational elongation regulation), with additional stress-related terms (ischemia, hypoxia) and metabolic signaling (insulin stimulus). The common theme is regulation of RNA metabolism and translation in response to cellular stress and metabolic cues.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034462","count":1},{"id":"GO:0002931","count":1},{"id":"GO:0032869","count":1},{"id":"GO:0045451","count":1},{"id":"GO:0006378","count":1}]},{"hash":"1682385190072899256","title":"Light-Response and MAPK Stress Signaling","description":"The GO terms cluster around responses to light and UV-A, regulation of cellular response to heat, and especially the stress-activated MAPK cascade, with an eye-related term (lens fiber cell morphogenesis) suggesting a possible ocular context. While other terms are more general (e.g., muscle contraction, intracellular transport), the dominant theme is light-induced stress signaling, making this a reasonable, compact label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070141","count":1},{"id":"GO:1900034","count":1},{"id":"GO:1905907","count":1},{"id":"GO:0009644","count":1},{"id":"GO:0006936","count":1}]},{"hash":"243796493230671705","title":"Sugar and ion transmembrane transporters","description":"The top GO terms cluster around transport across membranes for sugars (glucose, fructose, galactose, trehalose, fructose import) and inorganic ions (potassium, nitrate, nitrite), along with a related osmotic stress response. This suggests a cluster of membrane transporter proteins with broad substrate specificity (likely sugar and ion transporters), rather than enzymes or signaling proteins, possibly resembling MFS-like transporters or similar carriers.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0071332","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015706","count":3}]},{"hash":"561867946689429126","title":"Unknown","description":"The top GO terms span multiple developmental processes (eye, brain, embryonic development) and some immune signaling, with an obsolete entry and very sparse connections, so there is no single coherent function linking these four proteins.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000320","count":1},{"id":"GO:2000177","count":1},{"id":"GO:0035947","count":1},{"id":"GO:0043010","count":1},{"id":"GO:0033092","count":1}]},{"hash":"1536306185746284227","title":"Developmental transcriptional regulation","description":"The top GO terms cluster around diverse developmental processes (lung vasculature, somitogenesis, floor plate development, multiple differentiation pathways) along with general transcriptional activity (DNA-templated transcription, RNA polymerase II). This points to proteins that regulate development through transcriptional control across different tissues, rather than a single tissue-specific function.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060426","count":2},{"id":"GO:0001756","count":2},{"id":"GO:0033504","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006366","count":2}]},{"hash":"1442978119586622731","title":"Unknown","description":"The top GO terms are scattered across innate immune signaling, RNA processing and localization in oocytes, and various development and differentiation processes, with no single cohesive function tying the proteins together. This makes a clear, specific label unreliable.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":2},{"id":"GO:0045451","count":1},{"id":"GO:0008103","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0000184","count":1}]},{"hash":"2074373558946837904","title":"Extracellular matrix remodeling and coagulation","description":"The top GO terms cluster around extracellular matrix dynamics and vascular/immune processes (blood coagulation, hyaluronan metabolism, extracellular matrix assembly, cell adhesion, and extravasation), indicating a cohesive theme of ECM remodeling and coagulation/immune interactions, despite some unrelated terms in the list.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0030212","count":3},{"id":"GO:0045123","count":3},{"id":"GO:0034113","count":3},{"id":"GO:0006511","count":3}]},{"hash":"1461420769241668821","title":"Translational Regulation and Cell Cycle Control","description":"The GO terms cluster around translation (translation; regulation of translation) and regulation of the cell cycle, with a virus-response term, suggesting a theme of coordinating protein synthesis with cell-cycle progression rather than metabolism. Some obsolete biosynthetic terms are present, so the core signal is translation control linked to cell-cycle regulation.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045787","count":1},{"id":"GO:0006417","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0009615","count":1},{"id":"GO:0009089","count":1}]},{"hash":"1937303503421380844","title":"Neural development and immune signaling","description":"The Top Terms center on nervous system development, axon guidance/extension, and related signaling (e.g., positive regulation of axon extension, negative regulation of axonogenesis, nervous system development, JNK cascade, focal adhesion), with a notable emphasis on dopamine-related signaling. Immune terms (T cell receptor signaling, mast cell degranulation) appear but likely reflect shared signaling components rather than a cohesive immune function, so the label captures the dominant neural development theme with some cross-talk. ","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046330","count":3},{"id":"GO:0031647","count":3},{"id":"GO:0051893","count":3},{"id":"GO:0000278","count":3},{"id":"GO:1903351","count":3}]},{"hash":"1123542825251683005","title":"ER-associated Protein Processing and Trafficking","description":"The top GO terms cluster around processes linked to the endoplasmic reticulum and membrane-related protein handling: tail-anchored protein insertion into the ER membrane, deglycosylation, GPCR internalization regulation, ER stress\u2013related apoptotic signaling, and protein sumoylation. While there are also broader terms like ribosomal assembly and transcription regulation, the recurring theme is membrane-protein biogenesis, modification, and trafficking within the ER context.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071816","count":4},{"id":"GO:0006517","count":4},{"id":"GO:0060334","count":4},{"id":"GO:1902236","count":4},{"id":"GO:0000028","count":4}]},{"hash":"886882974464003244","title":"Calcium signaling in EMT and cytoskeletal dynamics","description":"The terms focus on calcium-dependent signaling (calcium channel regulation, calcium-related pathways, insulin secretion coupling to calcium) and on epithelial-to-mesenchymal transition, cytoskeletal remodeling (actomyosin, contractile structures, transport), plus related developmental contexts. This points to a cohesive module where calcium signaling modulates EMT-related plasticity and cytoskeletal organization, consistent with the inclusion of muscle/diaphragm contraction and developmental processes like metanephric development. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001837","count":4},{"id":"GO:0007223","count":4},{"id":"GO:0035774","count":4},{"id":"GO:1901841","count":4},{"id":"GO:0035191","count":4}]},{"hash":"1556548052477766454","title":"Mitochondrial Respiration and ROS Defense","description":"This cluster centers on mitochondrial electron transport (GO:0006122) and oxidative stress handling (GO:0098869, GO:0042743), with proton transmembrane transport supporting membrane potential, suggesting a coherent module of respiration and detoxification of reactive oxygen species. Some terms like photosynthesis are peripheral or context-specific, but the dominant signals support this mitochondrial energy production and ROS protection theme.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006122","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0015992","count":1},{"id":"GO:0006470","count":1}]},{"hash":"1031234104198957173","title":"Redox homeostasis and antioxidant metabolism","description":"The top GO terms converge on redox balance and antioxidant defense (cell redox homeostasis, glutathione metabolism, removal of superoxide radicals, oxidation-reduction processes) alongside links to aerobic respiration and stress responses, indicating a cohesive redox/antioxidant functional cluster for these proteins.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0019646","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0019430","count":2},{"id":"GO:0019483","count":2}]},{"hash":"1099022163811085315","title":"Nucleolar transcription and chromatin regulation","description":"This cluster centers on nucleolar transcription by RNA Pol I, nucleolar chromatin organization, and links to chromosome cohesion and DNA replication fidelity, suggesting a cohesive role in nucleolar transcriptional control and genome maintenance during the cell cycle.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901838","count":1},{"id":"GO:0045876","count":1},{"id":"GO:0070816","count":1},{"id":"GO:1990700","count":1},{"id":"GO:0051026","count":1}]},{"hash":"2219778994669133851","title":"Light and heat stress signaling with growth regulation","description":"This cluster centers on GO terms related to responses to UV-A and high light, and includes stress-activated MAPK cascade and negative regulation of cell growth and intracellular transport. Together these suggest a theme of environmental stress sensing and signaling that modulates growth and cellular processes, even though some terms (lens morphogenesis, muscle contraction) may reflect tissue-specific roles. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070141","count":2},{"id":"GO:1900034","count":2},{"id":"GO:1905907","count":2},{"id":"GO:0009644","count":2},{"id":"GO:0006936","count":2}]},{"hash":"1078818046408384447","title":"ECM Remodeling and EMT with Integrin Signaling","description":"The top GO terms cluster around extracellular matrix organization (fibronectin and collagen fibrils), epithelial-to-mesenchymal transition, and endothelial cell migration, with integrin-mediated signaling also highlighted. This points to a cohesive module of ECM remodeling and cell adhesion/migration processes, where integrin signaling modulates adhesion and movement. Some terms (endocytosis, immune regulation) appear ancillary but do not overshadow the central ECM/EMT theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905590","count":1},{"id":"GO:0001837","count":1},{"id":"GO:0010886","count":1},{"id":"GO:0030199","count":1},{"id":"GO:0043542","count":1}]},{"hash":"1049147182135854323","title":"Chromatin organization and nucleosome assembly","description":"This cluster\u2019s top GO terms center on chromatin structure and nucleosome dynamics (nucleosome assembly, heterochromatin organization, protein localization to chromatin), indicating a shared role in chromatin organization and nuclear architecture, despite some obsolescence in terms. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":3},{"id":"GO:0006334","count":3},{"id":"GO:0097298","count":3},{"id":"GO:0098532","count":3},{"id":"GO:0016584","count":3}]},{"hash":"670485877820163000","title":"Translation initiation and preinitiation complex assembly","description":"This cluster is dominated by GO terms related to translation initiation, preinitiation complex formation, and associated processes (IRES-dependent initiation, eIF4F complex assembly, translation reinitiation). While a minority of terms touch on RNA processing or silencing, the strongest signals point to ribosome recruitment and initiation of translation, indicating a role in translation initiation control and complex assembly.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0048026","count":3}]},{"hash":"2281001622374332454","title":"Unknown","description":"The four proteins link to a wide variety of processes (neural development, blood coagulation, embryo implantation, BMP signaling, phosphorylation regulation, calcium import, receptor clustering, spermatogenesis, stress fiber assembly, and GPCR signaling). There is no single, cohesive function that unites these terms beyond generic regulatory roles, so a specific, representative label is not supported by the data.","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":1},{"id":"GO:0007596","count":1},{"id":"GO:0007566","count":1},{"id":"GO:0030514","count":1},{"id":"GO:0050732","count":1}]},{"hash":"1495693586066390628","title":"DNA replication and mitotic cell cycle","description":"The strongest GO signals are for DNA replication and cell cycle transitions (G1/S, G2/M) and mitosis, suggesting these proteins mainly participate in DNA duplication and chromosome segregation. A few terms on nervous system development and RNA localization appear secondary, indicating some multifunctionality but not a unifying theme beyond cell division. ","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0045773","count":2},{"id":"GO:0000086","count":2}]},{"hash":"1653665185727545269","title":"NF-kappaB signaling and stress-responsive growth","description":"The top GO terms point to canonical NF-kappaB signaling, apoptosis regulation, xenobiotic response, and cell growth, suggesting a theme of stress- or insult-responsive signaling that modulates survival and growth via NF-kappaB\u2013related pathways and PTMs like methylation. Some terms (sterol biosynthesis, nodulation, ribosomal export) are less clearly connected and may reflect incidental hits in this small cluster, but the dominant pattern centers on NF-kappaB\u2013mediated stress responses affecting growth and apoptosis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006479","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0043065","count":2},{"id":"GO:2001015","count":2}]},{"hash":"1785604237966286296","title":"Musculoskeletal development regulation","description":"The top GO terms cluster around regulation of differentiation in musculoskeletal lineages: negative regulation of osteoblast differentiation, negative regulation of myotube differentiation, and regulation of skeletal muscle fiber development. Other terms touch on broader chromatin/telomere regulation and protein quality control, but the dominant signal is regulation of musculoskeletal development.  ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070845","count":4},{"id":"GO:0045668","count":4},{"id":"GO:0060766","count":4},{"id":"GO:0070932","count":4},{"id":"GO:0090050","count":4}]},{"hash":"571430964226097868","title":"Biosynthesis and RNA/Protein Modification","description":"The GO terms cluster around multiple biosynthetic pathways (sterol, biotin, polyamine, ubiquinone), suggesting metabolic production roles, and also include RNA and protein modification processes (rRNA methylation, peptidyl-arginine hydroxylation, protein methylation) plus ribosomal subunit export. This points to a broader theme of metabolism combined with RNA/protein modification and ribosome biogenesis, rather than a single cohesive pathway. Confidence: Medium","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":1},{"id":"GO:0009877","count":1},{"id":"GO:0006479","count":1},{"id":"GO:0000056","count":1},{"id":"GO:0090398","count":1}]},{"hash":"686551560692559510","title":"Cartilage and Bone Formation","description":"The cluster centers on endochondral and intramembranous ossification, cartilage condensation, and growth plate chondrocyte development, indicating a primary role in skeletal formation. While a few terms concern broader developmental morphogenesis, the dominant signal is cartilage/bone formation.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":2},{"id":"GO:0001502","count":2},{"id":"GO:1903225","count":2},{"id":"GO:2000860","count":2},{"id":"GO:0003431","count":2}]},{"hash":"1394679913956058454","title":"Unknown","description":"The GO terms span cell division, transcription, membrane dynamics, signaling, and development with no single dominant process or pathway linking all proteins; the terms are too heterogeneous to assign a coherent, specific function label, so the cluster remains Unknown. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0010762","count":2},{"id":"GO:0006360","count":2},{"id":"GO:0031584","count":2},{"id":"GO:0035564","count":2}]},{"hash":"1119083332121402430","title":"Unknown","description":"The top GO terms describe highly disparate processes (ribosomal RNA maturation, epithelial proliferation regulation in prostate development, histone methylation, cellular fusion, viral mRNA export, defense against Gram-positive bacteria, mitotic spindle regulation, hypoxia response, TGF-beta signaling, and ubiquitin-dependent ERAD). With no edges or cohesion among proteins, there is no clear shared function to label; thus Unknown with no confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":1},{"id":"GO:0060770","count":1},{"id":"GO:0051568","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0046784","count":1}]},{"hash":"1280767094261764567","title":"Microbial metabolism and biosynthesis","description":"This cluster is dominated by GO terms for biosynthetic and catabolic metabolism in bacteria, including antibiotic biosynthesis, menaquinone and phylloquinone biosynthesis, fatty acid beta-oxidation, and amino/phenylacetate/valine catabolism. A few stress-related terms (UV-A response, regulation of heat response) occur but are less represented, suggesting metabolism-focused functional grouping rather than a single stress pathway.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0010124","count":2},{"id":"GO:0042372","count":2},{"id":"GO:0006635","count":2}]},{"hash":"49925663958097245","title":"Nuclear DNA replication and telomere maintenance","description":"The top GO terms are strongly dominated by nuclear DNA metabolism: DNA replication, DNA-templated transcription, and mRNA processing, plus telomere maintenance and telomere capping. While terms like fat cell differentiation and response to muscle stretch appear, they are less central to the dominant theme of DNA replication/transcription and telomere regulation, suggesting a cluster of proteins with a primary role in nuclear genome maintenance with some peripheral regulatory connections.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0045444","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0032212","count":3}]},{"hash":"1933725829533712109","title":"ER Stress Response and Protein Quality Control","description":"This cluster centers on GO terms related to unfolded protein response, ER stress signaling, and SRP-dependent targeting to the ER, pointing to roles in protein folding, trafficking to the membrane, and stress-related apoptosis regulation. Some terms (fungal mating and cell wall biosynthesis) appear less connected and may reflect noise or incidental associations.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":4},{"id":"GO:1903382","count":4},{"id":"GO:0006880","count":4},{"id":"GO:0016226","count":4},{"id":"GO:0034620","count":4}]},{"hash":"1742665707762683068","title":"Vascular development and ECM-adhesion signaling","description":"The GO terms point to processes involved in blood vessel formation and ECM interactions, including blood coagulation, smooth muscle development, integrin signaling, cell adhesion, and extracellular matrix remodeling (hyaluronan metabolism, extravasation). While one term hints at craniofacial development and another at erythrocyte differentiation, the dominant theme is vascular development coupled with ECM-mediated adhesion and signaling, making the proposed label representative of the cluster\u2019s function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0006929","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0048745","count":2},{"id":"GO:0060324","count":2}]},{"hash":"1584068625569642694","title":"Proteostasis and Autophagy","description":"The top GO terms cluster around protein quality control and degradation: aggresome assembly and autophagy point to cellular proteostasis, with involvement in ubiquitin-dependent degradation pathways. Some terms are more developmental or signaling-based, but the dominant theme is protein homeostasis and degradation pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070842","count":2},{"id":"GO:0006914","count":1},{"id":"GO:1900458","count":1},{"id":"GO:0072089","count":1},{"id":"GO:2000059","count":1}]},{"hash":"1421230151890274493","title":"Chromatin organization and nucleosome assembly","description":"The top GO terms are dominated by chromatin-related processes\u2014nucleosome assembly, heterochromatin organization, histone modifications, and establishment/localization to chromatin\u2014indicating a chromatin structural/regulatory cluster. A few terms about stress granules or P-bodies appear but are not central to the main theme.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":1},{"id":"GO:0006334","count":1},{"id":"GO:0097298","count":1},{"id":"GO:0098532","count":1},{"id":"GO:0016584","count":1}]},{"hash":"1378145857745336263","title":"Regulation of NK and T cell responses","description":"The set of GO terms centers on immune regulation, with multiple entries about regulation of NK cell cytotoxicity, cytotoxic T cell differentiation, adaptive immune response, and tolerance induction, indicating a cluster tied to cytotoxic lymphocyte control and adaptive immunity. A few terms about symbiont entry or fat cell proliferation are outliers.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045404","count":2},{"id":"GO:0002859","count":2},{"id":"GO:0045065","count":2},{"id":"GO:0002860","count":2},{"id":"GO:0002652","count":2}]},{"hash":"1667142793113206597","title":"Neuronal signaling and autonomic regulation","description":"These proteins map to neurotransmitter signaling (serotonin and dopamine), synaptic transmission (including cholinergic and micturition-related), and membrane depolarization, with additional terms for autonomic heart rate regulation and CNS development (lateral geniculate nucleus and vestibulocochlear nerve). The common thread is neural signaling coupled with autonomic control and brain development.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0033603","count":4},{"id":"GO:0001988","count":4},{"id":"GO:0021771","count":4}]},{"hash":"641991700657156523","title":"Ubiquitin-Dependent Degradation and Immune Signaling","description":"The dominant GO terms are ubiquitination and ubiquitin-dependent protein catabolic processes, including autophagy and ERAD, with concurrent hints of immune signaling (NF-kappaB, TNF pathways) and T cell proliferation. This suggests a functional cluster tied to protein turnover that modulates immune responses.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0048535","count":2},{"id":"GO:0006914","count":2},{"id":"GO:0085020","count":2}]},{"hash":"1173560544346956909","title":"Blood coagulation and fibrinolysis","description":"The top GO terms are dominated by blood coagulation and fibrinolysis, with related negative regulation terms, indicating a primary theme around coagulation cascade and clot dissolution. A few other terms appear unrelated (e.g., molybdenum cofactor biosynthesis, receptor clustering), but the coagulation/fibrinolysis cluster is the strongest shared function among these proteins.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0051918","count":2},{"id":"GO:0042730","count":2},{"id":"GO:0018315","count":1}]},{"hash":"991861545928711652","title":"Regulation of cell proliferation and apoptosis","description":"The top GO terms are dominated by processes that control cell growth, division, and survival (cell division; positive regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of canonical Wnt signaling; axon extension), with cell migration also implicated. This points to a theme of growth control, proliferation restraint, and cell fate decisions, potentially extending to neural development. A couple of terms (response to cocaine, nodulation) seem peripheral noise. Overall, the label reflects the core shared function of the cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0090090","count":2}]},{"hash":"637531582909355685","title":"Immune signaling regulation and cytotoxic activity","description":"The terms cluster around dampening of immune signaling (negative regulation of IL-2 signaling, TLR9 signaling, and p38 MAPK cascade), regulation of receptor turnover and cell adhesion, and cytotoxic effector potential (positive regulation of granzyme B production). A couple of terms appear less related (e.g., vestibular morphogenesis), but the dominant pattern points to immune response modulation and cytotoxic regulation.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902206","count":4},{"id":"GO:2000646","count":4},{"id":"GO:0060116","count":4},{"id":"GO:0071225","count":4},{"id":"GO:0033629","count":4}]},{"hash":"1849853586198189880","title":"Cardiovascular GPCR Signaling and Calcium Dynamics","description":"This cluster is dominated by GO terms tied to GPCR signaling leading to adenylate cyclase activation, calcium release, prostaglandin responses, and regulation of blood pressure, plus cardiac vascular smooth muscle differentiation and coagulation. These collectively point to signaling pathways that regulate vascular tone and cardiovascular function, with calcium dynamics playing a central role. The electron transport chain term is a broader cellular energy facet, but the prominent theme remains cardiovascular signaling and calcium regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":4},{"id":"GO:0022900","count":4},{"id":"GO:0007190","count":4},{"id":"GO:0045777","count":4},{"id":"GO:0032651","count":3}]},{"hash":"884643390503072910","title":"Embryonic Morphogenesis and Epithelial Migration","description":"The cluster shows strong enrichment for developmental morphogenesis terms (CNS morphogenesis, axis elongation, somitogenesis, nail development) and epithelial processes (cell\u2013cell adhesion, epithelial cell migration), suggesting roles in embryonic tissue patterning and epithelial dynamics. A few entries relate to host\u2013pathogen interactions, but the dominant theme is development and morphogenesis, making this label representative of the group's function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0010888","count":1},{"id":"GO:0021551","count":1},{"id":"GO:0010745","count":1}]},{"hash":"1205333090821387709","title":"Neuronal development and heterophilic adhesion","description":"The most represented term is heterophilic cell-cell adhesion, pointing to adhesion-mediated interactions. The presence of cerebellar Purkinje cell layer development and in utero embryonic development terms supports a neural development context. Additional terms related to lysosome targeting and receptor internalization suggest membrane trafficking tied to receptor turnover in developing neurons, reinforcing a neuronal development/adhesion theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:1902960","count":2},{"id":"GO:0010572","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0006622","count":2}]},{"hash":"220912172606146138","title":"Unknown","description":"The top GO terms are a mixed bag: several acetylation-related processes (histone acetylation, peptidyl-lysine acetylation, N-terminal acetylation) alongside diverse metabolic and developmental processes (mycothiol biosynthesis, glucosamine metabolism, L-arginine biosynthesis, melatonin biosynthesis, angiogenesis). This broad and cross-species mix suggests no single cohesive function for the cluster, making a specific, intuitive label unreliable.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0060358","count":4},{"id":"GO:0017198","count":4},{"id":"GO:0006041","count":4}]},{"hash":"1880133911856226190","title":"Immune Activation and Leukocyte Trafficking","description":"The top GO terms cluster around immune cell activation and recruitment, including phagocytosis recognition, leukocyte tethering/rolling, basophil activation, and regulation of NK cell chemotaxis, as well as inflammatory signaling such as arachidonate secretion. Some developmental terms (mesonephric duct and distal tubule morphogenesis) appear but do not define the main theme; overall the proteins are best labeled as involved in immune activation and leukocyte trafficking.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":4},{"id":"GO:0006910","count":4},{"id":"GO:0010572","count":4},{"id":"GO:0045575","count":4},{"id":"GO:0050901","count":4}]},{"hash":"2244131048652754230","title":"Unknown","description":"The GO terms are highly heterogeneous, including meiotic recombination and DNA repair, transcription regulation, plant reproductive development, and unrelated processes like blood coagulation and aldosterone secretion, with no clear shared function or interaction among the proteins.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007131","count":1},{"id":"GO:0045892","count":1},{"id":"GO:0009553","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006351","count":1}]},{"hash":"723218555832116165","title":"Innate immune sensing and macrophage activation","description":"The terms point to innate immune recognition of bacterial components (LPS) and macrophage/dendritic cell activation, with accompanying cytoskeletal signaling; other terms appear peripheral or species-specific noise.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032497","count":1},{"id":"GO:0002730","count":1},{"id":"GO:0042700","count":1},{"id":"GO:0050830","count":1},{"id":"GO:0007189","count":1}]},{"hash":"1787034399330647650","title":"Neuronal signaling and synaptic transmission","description":"The top GO terms cluster around neural signaling and synaptic activity, including serotonin receptor signaling, dopamine secretion, cholinergic synaptic transmission, membrane depolarization, and potassium transport. Development terms for auditory/visual pathways and locomotion further support a neural circuitry context, pointing to neuronal communication and regulation of neural activity.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007210","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0033603","count":1},{"id":"GO:0001988","count":1},{"id":"GO:0021771","count":1}]},{"hash":"72766990799338981","title":"Cell stress and quality-control responses","description":"The terms cluster around stress-related processes (ischemia, response to cocaine), detection of misfolded proteins, and apoptotic regulation, with supporting nuclear processes like pore complex assembly and Cajal body localization. Together these suggest a theme of cellular stress management and nuclear protein quality control rather than a single specific pathway.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0002931","count":3},{"id":"GO:0014823","count":3},{"id":"GO:0051973","count":3},{"id":"GO:1904871","count":3}]},{"hash":"1142746242968683875","title":"Broad Developmental Signaling","description":"This cluster combines GO terms tied to various signaling pathways and developmental processes across multiple tissues, including neuronal guidance (axon guidance, nervous system development, ROBO pathway), growth and maturation (ossification, spermatid development), and general immune signaling (mast cell chemotaxis, T cell receptor signaling) as well as common signaling regulators (ERK cascade, ubiquitination). The terms point to a broad, cross-tissue set of signaling events rather than a single, cohesive function, so a generic \u201cdevelopmental signaling\u201d label fits best.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002551","count":2},{"id":"GO:0035385","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0007399","count":2}]},{"hash":"297705038263788369","title":"Ribosome Biogenesis and RNA Processing","description":"Top terms cluster around ribosome production and RNA maturation (cytosolic ribosome assembly, rRNA maturation/processing, preribosome assembly, and rRNA base methylation), with additional signals from mRNA capping and tRNA methylation. This dominant ribosome/ RNA-processing theme supports labeling the cluster as ribosome biogenesis and related RNA processing.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":1},{"id":"GO:0042256","count":1},{"id":"GO:0097310","count":1},{"id":"GO:0019062","count":1},{"id":"GO:0039520","count":1}]},{"hash":"1892777381657260974","title":"Unknown","description":"This cluster's top GO terms are highly diverse (ribosomal RNA maturation, prostate development, histone methylation, cell fusion, viral mRNA export, immune defense, mitotic regulation, hypoxia, TGF-beta signaling, ubiquitin ERAD), with no shared pathway or clear functional theme. There are no edges and only three proteins, making it impossible to identify a cohesive biological function. Therefore, Unknown with no confidence is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":1},{"id":"GO:0060770","count":1},{"id":"GO:0051568","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0046784","count":1}]},{"hash":"552803124343773068","title":"Mitochondrial DNA replication and genome maintenance","description":"The top GO terms center on mitochondrial genome maintenance and DNA metabolism, including mitochondrial DNA repair, mitochondrial genome maintenance, DNA recombination, replication fork dynamics (reversal and progression), and related DNA unwinding/repair processes. While a few telomere-associated terms appear, the core signal points to mitochondrial genome maintenance and general DNA replication/repair functions. Confidence in this label is medium.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":1},{"id":"GO:0032508","count":1},{"id":"GO:0043504","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0051974","count":1}]},{"hash":"51843117258432167","title":"Lens light-stress signaling and morphogenesis","description":"The top GO terms cluster around responses to UV-A and high light, plus a stress-activated MAPK cascade, and notably lens fiber cell morphogenesis. This suggests proteins in the cluster participate in light/heat stress signaling that shapes lens development, with additional regulatory steps affecting transport and protein interactions. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070141","count":3},{"id":"GO:1900034","count":3},{"id":"GO:1905907","count":3},{"id":"GO:0009644","count":3},{"id":"GO:0006936","count":3}]},{"hash":"1940324509056781014","title":"Unknown","description":"The terms span inflammatory signaling, calcium dynamics, prostaglandin response, coagulation, and vascular differentiation, but also include neural/behavioral and vision-related processes, with no single cohesive function tying all together. This small cluster does not map to a clear, common biological theme, so a specific label isn\u2019t justifiable.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032651","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0007596","count":2},{"id":"GO:2000724","count":2}]},{"hash":"1227049472274107032","title":"Ion transport and ionic homeostasis","description":"These terms cluster around membrane-based movement of ions (Na+, K+, H+) across membranes, including proton translocation and vacuolar acidification, which ties to cell volume regulation and salt stress response. The common theme is ion transport and maintenance of ionic/osmotic balance, rather than a single signaling pathway.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098719","count":1},{"id":"GO:0031547","count":1},{"id":"GO:0097623","count":1},{"id":"GO:0007035","count":1},{"id":"GO:0006884","count":1}]},{"hash":"1296080918996049404","title":"Ubiquitin-regulated immune signaling and apoptosis","description":"The top GO terms point to adaptive immune response, regulation of NF-kappaB and JNK signaling, and apoptosis control, with multiple ubiquitination processes (including K63- and K6-linked) highlighted. This suggests proteins in the cluster work together to modulate immune signaling and cell fate via ubiquitin-mediated regulation, connecting immune cell recruitment (neutrophil chemotaxis) to core signaling pathways. Confidence in this cohesive theme is High.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0030593","count":2}]},{"hash":"786726353506373341","title":"Auditory glutamatergic synapse","description":"This cluster centers on GO terms for glutamate secretion and chemical synaptic transmission, with an additional cue from sensory perception of sound, which together point to a role in glutamatergic signaling at auditory synapses. While some terms (like basolateral membrane localization or autophagy) are less central, the dominant theme is neuronal communication in the auditory system, aligning with glutamatergic synaptic function. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0014047","count":1},{"id":"GO:0070830","count":1},{"id":"GO:0006914","count":1},{"id":"GO:1903361","count":1},{"id":"GO:1901536","count":1}]},{"hash":"2277700594433474134","title":"Broad Negative Regulation of Diverse Cellular Processes","description":"The terms are dominated by negative regulation across diverse biological processes (e.g., cell migration, gluconeogenesis, stress response) with only a few other regulatory or unrelated actions, indicating a general regulatory role rather than a single pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090051","count":2},{"id":"GO:0045721","count":2},{"id":"GO:1901001","count":1},{"id":"GO:0010762","count":1},{"id":"GO:0031584","count":1}]},{"hash":"1225744167396505255","title":"Unknown","description":"There is no shared GO-term signal to define a common function among the three proteins, and no top terms are provided, so no clear theme emerges.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"176420108542657905","title":"Developmental morphogenesis and tissue remodeling","description":"The top GO terms point to embryo and tissue formation processes across species (somitogenesis, neural tube formation, spinal cord neuron specification, stamen formation) and related extracellular remodeling (hyaluronan metabolism, cell adhesion, extravasation), plus regulatory processes like ubiquitin-dependent protein catabolism. This suggests a theme of developmental patterning and morphogenesis with associated cellular interactions, even if some terms are plant-specific; hence the label reflects a cohesive developmental remodeling function. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001756","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0030212","count":3},{"id":"GO:0045123","count":3},{"id":"GO:0034113","count":3}]},{"hash":"618463912610976846","title":"Neural and Sensory Organ Morphogenesis","description":"The top GO terms center on development and differentiation of neural and sensory tissues (compound eye photoreceptor differentiation, optic nerve morphogenesis, CNS projection neuron axonogenesis, sensory perception of sound). Additional terms point to signaling and regulatory processes (forskolin response, JNK activity, poly-ADP-ribosylation) that can influence neural development. Some terms like pericyte and nephric duct morphogenesis indicate broader morphogenetic processes, but the core cluster appears to reflect formation and differentiation of neural and sensory structures.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001751","count":1},{"id":"GO:1904322","count":1},{"id":"GO:1903744","count":1},{"id":"GO:0070212","count":1},{"id":"GO:0021631","count":1}]},{"hash":"648420134356483840","title":"Redox Regulation and Oxidative Stress Response","description":"The top GO terms point to redox biology: negative regulation of peptidyl-cysteine S-nitrosylation and cellular response to hydroperoxide, with an obsolete related term about oxidative stress-induced neuron death. Although the cluster is small and contains no edges, the common theme appears to be modulation of redox state and peroxide/oxidative stress responses, suggesting proteins that participate in redox regulation. Confidence in this label is moderate given limited annotation depth.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902083","count":1},{"id":"GO:1903204","count":1},{"id":"GO:0071447","count":1}]},{"hash":"1107273540921587540","title":"Cardiac Development and Valvulogenesis","description":"The top GO terms cluster around heart development and morphogenesis, including cardiac muscle regeneration, cardioblast fate, endocardial cushion formation, and aortic valve morphogenesis, indicating a coherent theme of cardiac development; a few terms appear unrelated and may reflect background annotations.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061026","count":3},{"id":"GO:0007510","count":3},{"id":"GO:0033600","count":3},{"id":"GO:0090295","count":3},{"id":"GO:0003180","count":3}]},{"hash":"1317192943099818037","title":"GTPase-regulated vesicle trafficking and endosome transport","description":"These proteins are connected by small GTPase signaling and membrane trafficking processes, notably positive regulation of GTPase activity and endosome-to-lysosome transport. While a few terms reflect peripheral or historical annotations (e.g., certain polarity and development terms), the dominant theme is GTPase-driven vesicle trafficking. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0061000","count":1},{"id":"GO:1902647","count":1},{"id":"GO:0007289","count":1},{"id":"GO:0030037","count":1}]},{"hash":"1757789166479612817","title":"Unknown","description":"The top terms are inconsistent: DNA recombination and double-strand break repair pair with lymphocyte differentiation and an obsolete ERAD term, with no shared function or interaction pattern. This makes it unclear what biological role ties these proteins, so Unknown with None confidence.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904378","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0030217","count":1},{"id":"GO:0030183","count":1},{"id":"GO:0097680","count":1}]},{"hash":"1345132241014026098","title":"Unknown","description":"No GO terms are listed for this cluster (Top Terms is empty), and with only a single edge and no clear common function, there is no defensible shared biological role to name. Thus I cannot assign a specific label; Unknown is the appropriate designation with no confidence.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"827058758790233184","title":"Unknown","description":"There are no GO terms or connections to define a shared function for these three proteins, and edges/triangles are absent, so a coherent biological theme cannot be inferred. The mention of additional proteins by ReCIPE does not provide a meaningful functional link for this cluster. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"668033501651784149","title":"Sugar and ion transmembrane transporters","description":"This cluster\u2019s GO terms predominantly reflect transmembrane transport across membranes, including sugars (glucose, galactose, fructose, trehalose), vitamins, xenobiotics, and ions like potassium, along with an osmotic stress response. This pattern strongly suggests a group of membrane transporter proteins with broad sugar and ion substrate specificity.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0071332","count":2}]},{"hash":"1662775708791350447","title":"Ubiquitination and Autophagy in Immune Signaling","description":"The top terms cluster around post-translational modification (ubiquitination and SUMOylation), protein degradation pathways (autophagy, ERAD), and immune-related processes (lymph node development, T cell proliferation). Although some terms are obsolete, these repeatedly point to regulation of immune signaling via ubiquitin/SUMO pathways and associated degradation mechanisms, suggesting this cohesive theme for the cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048535","count":2},{"id":"GO:0090309","count":2},{"id":"GO:0006914","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0085020","count":2}]},{"hash":"2034893565572353186","title":"Unknown","description":"The top terms are highly disparate, spanning mitochondrial processes (mitochondrial inheritance, mtDNA replication, mitochondrion morphogenesis), cell adhesion (cadherin-mediated), podocyte development, immune/polarity (T cell polarity), and dopaminergic synaptic transmission, with several terms marked obsolete. There isn\u2019t a single coherent biological theme tying these proteins together, suggesting the cluster is not functionally cohesive. Therefore an Unknown label is most appropriate.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1901585","count":2},{"id":"GO:2000049","count":2},{"id":"GO:0072249","count":2},{"id":"GO:0070584","count":2},{"id":"GO:0045541","count":2}]},{"hash":"1394960298274477481","title":"Ubiquitin-Dependent Protein Turnover","description":"These proteins show a strong emphasis on ubiquitin-related regulation, including ubiquitin-dependent protein catabolic processes and deubiquitination (including K33-linked deubiquitination). Supporting terms touch on nuclear import and RNA-related regulation, which can tie into ubiquitin-mediated turnover of nuclear proteins. Overall, the common theme is ubiquitin-mediated protein regulation and degradation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990168","count":3},{"id":"GO:0090526","count":3},{"id":"GO:0008380","count":3},{"id":"GO:0006977","count":3},{"id":"GO:0006607","count":3}]},{"hash":"804676122981960785","title":"Excitatory synaptic signaling and ion transport","description":"The dominant GO terms point to neuronal communication: excitatory postsynaptic potential and transmembrane transport of sodium and potassium ions, which are core to synaptic transmission and neuronal excitability. The presence of actin filament organization supports synaptic structuring, while calcium-related terms and the other single-hit annotations suggest additional, more peripheral roles. Overall, the cluster seems to reflect neuronal signaling with a focus on ion transport across membranes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0001837","count":1},{"id":"GO:0007223","count":1}]},{"hash":"265057967562755235","title":"Cardiac Electrophysiology and Calcium Signaling","description":"GO terms cluster around membrane potential regulation and calcium transport, with emphasis on cardiac-specific processes like bundle of His depolarization/repolarization and atrial muscle membrane dynamics. While a few terms point to endocrine or sensory roles, the core theme is ion channel\u2013driven electrical activity in excitable tissues, especially the heart; given the small protein set, this label is plausible though tentative.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060081","count":1},{"id":"GO:0060453","count":1},{"id":"GO:0086048","count":1},{"id":"GO:0032342","count":1},{"id":"GO:0050968","count":1}]},{"hash":"710557716278954814","title":"Actin Remodeling in Oligodendrocyte Development","description":"The top GO terms cluster around actin cytoskeleton dynamics (parallel actin filament bundle assembly, lamellipodium/stress fiber assembly, actin filament severing) and oligodendrocyte development/myelination, suggesting these proteins are linked to actin remodeling processes during oligodendrocyte maturation and myelin formation. Some immune and mitochondrial regulation terms are present but do not define the primary theme. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030046","count":2},{"id":"GO:2000402","count":2},{"id":"GO:0031643","count":2},{"id":"GO:0090140","count":2},{"id":"GO:0051497","count":2}]},{"hash":"1009005582239250672","title":"Neural Axon Guidance and Eye Morphogenesis","description":"This cluster's top GO terms converge on neural development and connectivity, including axonogenesis and fasciculation of sensory neuron axons, and CNS projection neuron axonogenesis, along with eye-related morphogenesis such as compound eye photoreceptor differentiation and optic nerve morphogenesis. The combination suggests a shared theme of neural wiring and sensory organ development, especially along the eye/optic nerve axis.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":3},{"id":"GO:1902960","count":3},{"id":"GO:0001751","count":3},{"id":"GO:1904238","count":3},{"id":"GO:0021631","count":3}]},{"hash":"1582649351169720634","title":"Cell Cycle and Division","description":"The top GO terms are dominated by cell division and cell cycle (GO:0051301 and GO:0007049), each with three proteins, suggesting the cluster is centered on proliferative or mitotic processes. A ribosomal large subunit export from nucleus term appears with the same count but is less central to the overall theme, so the core signal is cell cycle/division rather than general RNA export or other peripheral processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0010762","count":2},{"id":"GO:0031584","count":2}]},{"hash":"142543806869445522","title":"Unknown","description":"No shared GO terms or network connectivity are provided to link these proteins into a common function. The cluster shows zero edges/triangles and no top terms, so a coherent label cannot be inferred from the data available.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"181006758626593678","title":"Spliceosome and RNA Processing","description":"The cluster shows strong emphasis on RNA processing and splicing: spliceosomal complex assembly, mRNA splicing via spliceosome, maturation of SSU-rRNA, and mRNA decapping/P-body-related processes, along with nuclear import and transcription termination\u2014together pointing to a cohesive RNA metabolism/splicing module.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000245","count":1},{"id":"GO:1990141","count":1},{"id":"GO:0030490","count":1},{"id":"GO:0033962","count":1},{"id":"GO:0006369","count":1}]},{"hash":"1509251052706787702","title":"Nervous system development and glutamate synapse signaling","description":"The cluster shows strong representation of nervous system development terms (axon midline choice point recognition, nervous system development, morphogenesis) along with synaptic signaling components (ionotropic glutamate receptor signaling, regulation of synapse structure/activity) and neural plasticity (collateral sprouting). This pattern suggests proteins involved in neuronal development and glutamatergic synaptic function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016199","count":1},{"id":"GO:0060670","count":1},{"id":"GO:0007399","count":1},{"id":"GO:1990000","count":1},{"id":"GO:0060672","count":1}]},{"hash":"508361054594117205","title":"Unknown","description":"There are no GO terms or interactions linking these proteins (no edges, no shared annotations), so a coherent functional theme cannot be inferred from the data provided.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1170720568633233531","title":"Developmental chromatin regulation","description":"Based on the top GO terms, the cluster centers on chromatin-level control (histone modification and ubiquitination) with links to development (embryonic and neuron projection development) and DNA damage signaling, suggesting a developmental chromatin regulation module.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0001701","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0010976","count":3},{"id":"GO:0070076","count":3},{"id":"GO:0030433","count":3}]},{"hash":"2246718646918210641","title":"Ubiquitin-Proteasome\u2013Mediated Proteolysis in Meiosis","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes (including SCF-dependent proteasomal pathways) and meiosis-related events such as oocyte maturation and spindle assembly in female meiosis I, indicating a shared function in regulated proteolysis guiding meiotic cell-cycle progression. Additional terms connected to circadian rhythm regulation and neuronal signaling likely reflect broader roles of proteostasis and ubiquitin systems, but the dominant theme appears to be ubiquitin-proteasome\u2013driven protein turnover in meiosis and cell-cycle control.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001556","count":2},{"id":"GO:0042752","count":2},{"id":"GO:0031571","count":2},{"id":"GO:0007057","count":2},{"id":"GO:0006516","count":2}]},{"hash":"171639748320343428","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007014","count":2},{"id":"GO:0018032","count":2},{"id":"GO:2000637","count":2},{"id":"GO:1903886","count":2},{"id":"GO:0072089","count":2}]},{"hash":"356627713987215897","title":"Large subunit ribosome biogenesis and export","description":"The GO terms center on maturation and assembly of the large ribosomal subunit (including 5.8S and LSU rRNA processing), preribosome assembly, and nuclear export, indicating proteins in this cluster function in ribosome biogenesis rather than other processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":1},{"id":"GO:0000466","count":1},{"id":"GO:0000463","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0000055","count":1}]},{"hash":"655350348392295739","title":"Unknown","description":"The Top Terms are diverse and only loosely related, spanning immune-related processes (lymph node development, T cell proliferation, NF-kappaB activity) and broad protein regulation (ubiquitination, sumoylation, ERAD, autophagy, vesicle transport). There isn\u2019t a single cohesive function that ties the cluster together, so a concise, specific label isn\u2019t evident beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048535","count":1},{"id":"GO:0090309","count":1},{"id":"GO:0006914","count":1},{"id":"GO:1901536","count":1},{"id":"GO:0085020","count":1}]},{"hash":"601011384213309602","title":"Glutathione-dependent detoxification and redox metabolism","description":"The cluster\u2019s GO terms are centered on glutathione metabolism and related detoxification pathways (glutathione metabolic and derivative biosynthesis, xenobiotic catabolic and cellular detoxification of nitrogen compounds), with supporting signals of redox-related responses (ascorbic acid, insulin signaling) and basic amino acid metabolism. This pattern points to a shared function in antioxidant defense and detoxification processes mediated by glutathione and related redox chemistry.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030511","count":2},{"id":"GO:0035726","count":1},{"id":"GO:1901687","count":1},{"id":"GO:0032869","count":1},{"id":"GO:0009072","count":1}]},{"hash":"1787190322703039425","title":"Unknown","description":"The GO terms are highly diverse, ranging from ion transport and ER vesicle trafficking to mating signal transduction, cell cycle, tRNA modification, and plasmid partitioning, with no clear common function tying the proteins together. The lack of edges and a unifying biological process suggests no coherent cluster theme can be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0099133","count":1},{"id":"GO:0006859","count":1},{"id":"GO:0099132","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0000750","count":1}]},{"hash":"1924927523316407218","title":"Embryonic organ morphogenesis","description":"The proteins appear connected through developmental morphogenesis across several organs, highlighted by GO terms for pancreatic cell fate, nephron morphogenesis, S-shaped body morphogenesis, umbilical cord morphogenesis, and lung vasculature development, suggesting a shared role in organogenesis; other terms like circadian regulation or xenobiotic response are present but less central to the core theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003326","count":3},{"id":"GO:0003053","count":3},{"id":"GO:0048712","count":3},{"id":"GO:0071400","count":3},{"id":"GO:0009410","count":3}]},{"hash":"1995621605116272060","title":"Ribosome Biogenesis and RNA Processing","description":"This cluster is driven by GO terms for ribosomal large subunit biogenesis and LSU rRNA maturation, with several related RNA processing steps (e.g., ITS1 cleavage, rRNA transcription/processing). The presence of spliceosome and transcription-related terms suggests broader RNA maturation roles, but the dominant theme centers on ribosome assembly and rRNA processing, making this a cohesive RNA-centric functional group.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0043629","count":3},{"id":"GO:1990120","count":3},{"id":"GO:1903608","count":3}]},{"hash":"2106883838283081809","title":"Ribosome biogenesis and rRNA processing","description":"The cluster is strongly linked to ribosome assembly and rRNA maturation, as highlighted by terms for ribosomal large subunit biogenesis (GO:0042273) and LSU rRNA maturation (GO:0000463), with supporting activity in ITS1 rRNA processing (GO:0000464). While a few terms are obsolete or pertain to other RNA processing paths, the dominant signal points to proteins involved in ribosome biogenesis and rRNA processing.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0043629","count":1},{"id":"GO:1990120","count":1},{"id":"GO:1903608","count":1}]},{"hash":"1856447005068964159","title":"Neuronal cytoskeleton dynamics and transport","description":"The GO terms point to cytoskeleton regulation, microtubule-based movement, and neuron projection morphogenesis, indicating a focus on neuronal cytoskeleton dynamics and intracellular transport along microtubules. Some terms about viral intracellular transport and non-neuronal processes are present but appear as outliers relative to the core neuronal transport theme. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051493","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0007018","count":1},{"id":"GO:0019060","count":1},{"id":"GO:0075521","count":1}]},{"hash":"1694620200852929994","title":"Unknown","description":"The top GO terms are diverse (face morphogenesis, eye development, valve morphogenesis, lipid metabolism, kidney development, lipoprotein response) with only single representations, and the network has minimal connectivity (one edge, no triangles). There is no single coherent function tying these proteins together, so a specific, representative label cannot be derived.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0043010","count":1},{"id":"GO:0003180","count":1},{"id":"GO:0001573","count":1},{"id":"GO:0045598","count":1}]},{"hash":"55561932280688292","title":"Unknown","description":"The terms span neural development (paranode localization, trigeminal nerve development), vascular signaling (VEGF pathway), and various immune/differentiation processes, with no single dominant shared function among the proteins; therefore no coherent label can be assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":1},{"id":"GO:0021740","count":1},{"id":"GO:0038033","count":1},{"id":"GO:1904604","count":1},{"id":"GO:0002859","count":1}]},{"hash":"1318834347133009002","title":"Neuronal synaptic signaling and membrane-cytoskeleton dynamics","description":"This cluster is driven by GO terms related to neuronal signaling (regulation of GABAergic synaptic transmission and dopamine secretion), IP3-mediated signaling, and localization of proteins to the cortical microtubule cytoskeleton, plus membrane repair. While some terms (e.g., TNF, vascular remodeling) are less directly tied to neurons, the strongest and most frequent signals point toward synaptic signaling and membrane/cytoskeletal dynamics.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051345","count":2},{"id":"GO:0060313","count":1},{"id":"GO:1904468","count":1},{"id":"GO:0072699","count":1},{"id":"GO:0032228","count":1}]},{"hash":"1414754445189120516","title":"Lymphocyte development and activation","description":"The top terms cluster around lymph node development, T/B cell differentiation and proliferation, NF-kappaB signaling, and IL-17 pathways, pointing to a cohesive lymphocyte development and activation program; autophagy and apoptotic regulation suggest survival control in these cells.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048535","count":2},{"id":"GO:0061470","count":2},{"id":"GO:0006914","count":2},{"id":"GO:0042981","count":2},{"id":"GO:0090073","count":2}]},{"hash":"1368407023213681364","title":"Unknown","description":"The top GO terms are highly diverse and span animal developmental processes (somitogenesis, spinal cord association neuron specification), plant-specific processes (chlorophyll biosynthetic process, stamen formation), and miscellaneous functions (blood coagulation, hyaluronan metabolism, ubiquitin-dependent protein catabolic process, cell-cell adhesion). With only single-term representations and no shared pathway or function linking these terms, there is no coherent theme tying the proteins together. The evidence (edges 0, no shared terms beyond single annotations) does not support a specific functional label, so labeling as Unknown is most appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001756","count":1},{"id":"GO:0007596","count":1},{"id":"GO:0006471","count":1},{"id":"GO:0030212","count":1},{"id":"GO:0045123","count":1}]},{"hash":"662194580674501128","title":"Mitochondrial inner-membrane protein import","description":"These proteins cluster around mitochondrial targeting and inner-membrane insertion, as indicated by GO terms related to protein targeting to mitochondrion and protein insertion into the mitochondrial inner membrane. The presence of these terms suggests a shared role in mitochondrial protein import/assembly, despite the terms being historical/obsolete in some annotations.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":2},{"id":"GO:0072321","count":2},{"id":"GO:0045039","count":2}]},{"hash":"210918678301018365","title":"Ubiquitin-mediated chromatin regulation and NF-kappaB signaling","description":"These terms cluster around ubiquitin-related control of chromatin state (histone ubiquitination and acetylation), as well as immune-related processes (V(D)J recombination, NF-kappaB signaling) and transcriptional regulation (dosage compensation). The presence of ubiquitin pathways (K63- and K6-linked ubiquitination), ERAD, and NF-kB activation hints at a shared theme of ubiquitin-driven chromatin and transcriptional regulation linked to immune and cellular stress responses.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070535","count":2},{"id":"GO:0042981","count":2},{"id":"GO:0090073","count":2},{"id":"GO:0085020","count":2},{"id":"GO:0007250","count":2}]},{"hash":"308026006006415832","title":"ER protein maturation and stress signaling","description":"Many of the most represented terms point to endoplasmic reticulum\u2013associated protein maturation and quality control (e.g., tail-anchored protein insertion into the ER membrane, deglycosylation, and ER-stress\u2013related signaling). Additional terms reference post-translational modification and signaling regulation that can influence ER function or protein trafficking, with some terms only loosely linked to ER biology. Overall, the cluster appears best described by an ER-centric theme, though not all terms fit perfectly.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071816","count":2},{"id":"GO:0006517","count":2},{"id":"GO:0060334","count":2},{"id":"GO:1902236","count":2},{"id":"GO:0000028","count":2}]},{"hash":"909833512983779458","title":"Protein and RNA Modifications","description":"The cluster\u2019s GO terms mainly reflect macromolecule modification processes, including protein post-translational modifications (sumoylation, urmylation, lipidation) and RNA modifications (tRNA wobble thiolation, t6A biosynthesis). While a few terms touch other processes, the dominant theme is molecular modification pathways, implying these proteins participate in modification biology rather than a single, isolated function.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0018192","count":1},{"id":"GO:0016925","count":1},{"id":"GO:0002143","count":1},{"id":"GO:0044805","count":1},{"id":"GO:0034727","count":1}]},{"hash":"379185411346523263","title":"Nucleotide metabolism and DNA replication initiation","description":"Based on the top GO terms, the cluster is dominated by nucleotide metabolism activities: purine ribonucleotide interconversion, various nucleotide phosphorylation and biosynthesis processes, and AMP salvage. The presence of DNA replication initiation suggests a link to supplying nucleotides for DNA synthesis or replication-related functions. The liver and brain development terms appear less coherent with the main signal and may be incidental annotations. Overall, the main theme is nucleotide metabolism with a possible connection to DNA replication.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015951","count":2},{"id":"GO:0046940","count":2},{"id":"GO:0046039","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0007420","count":2}]},{"hash":"1438743711903366658","title":"Developmental ubiquitin signaling and chromatin remodeling","description":"This cluster centers on GO terms linking ubiquitination (including K6-linked ubiquitination and ubiquitin-dependent pathways) with chromatin-related processes (histone modification/ubiquitination) and DNA repair, alongside embryonic and neuron development terms. Together, these suggest a theme of ubiquitin- and chromatin-mediated regulation during development and genome maintenance.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0001701","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0010976","count":3},{"id":"GO:0070076","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1468997039848196378","title":"Unknown","description":"The GO terms are highly diverse and only appear once each, spanning proteasomal regulation, insulin signaling/catabolism, bradykinin catabolism, viral processes, membrane transport and respiration, and various forms of protein oligomerization. With no clear common function linking the proteins and no interactions (edges), there is no coherent theme to name the cluster beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":1},{"id":"GO:1901143","count":1},{"id":"GO:0010815","count":1},{"id":"GO:0016032","count":1},{"id":"GO:1902600","count":1}]},{"hash":"2079157186518389914","title":"Viral Translation Initiation and Reinitiation","description":"The top GO terms are dominated by translation-related processes: IRES-dependent viral translational initiation, formation of translation preinitiation complex, regulation of translational initiation, translation reinitiation, and viral termination-reinitiation, pointing to a cluster centered on the machinery and regulation of translation initiation, including viral mechanisms. There are also a couple of terms about DNA replication and meiosis, which may reflect broader cellular processes or annotation noise, but do not override the clear translation-focused signal. Confidence in this label reflecting the cluster\u2019s primary function is Medium. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0007127","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0001731","count":2}]},{"hash":"1858976171819993360","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":1},{"id":"GO:0006353","count":1},{"id":"GO:0036265","count":1},{"id":"GO:0098507","count":1},{"id":"GO:0048535","count":1}]},{"hash":"500504740576267557","title":"Epigenetic Regulation and Developmental Differentiation","description":"The top GO terms point to epigenetic control via CpG methylation and several differentiation-related processes across tissues (macrophage, hemangioblast, endocardial cushion, and tracheal system). The cluster seems to center on gene expression regulation coupled with lineage specification, rather than a single, cohesive pathway, so a label that combines epigenetic regulation with differentiation best fits.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":3},{"id":"GO:0044027","count":3},{"id":"GO:0070932","count":2},{"id":"GO:0033600","count":2},{"id":"GO:0030225","count":2}]},{"hash":"2021471035180707053","title":"Ribosome Biogenesis and rRNA Maturation","description":"The Top Terms include ribosomal large subunit biogenesis and maturation of LSU rRNA, plus specific rRNA processing steps like ITS1 cleavage, all pointing to nucleolar assembly and maturation of ribosomes. While an unrelated spliceosome term appears, the dominant theme is ribosome biogenesis and rRNA processing, suggesting these proteins function in ribosome assembly and RNA maturation. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0043629","count":3},{"id":"GO:1990120","count":3},{"id":"GO:0000464","count":3}]},{"hash":"1899022137862675385","title":"Mitochondrial rRNA processing and translation","description":"The GO terms center on maturation of 5.8S and LSU rRNAs from tricistronic mitochondrial transcripts and on translation, with supporting hints of mitochondrial autophagy regulation. Together, they suggest a cluster of proteins involved in mitochondrial ribosome maturation and mitochondrial protein synthesis.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":1},{"id":"GO:0000463","count":1},{"id":"GO:1903955","count":1},{"id":"GO:1903146","count":1},{"id":"GO:0006412","count":1}]},{"hash":"2036553150445349561","title":"Dopamine Metabolism and Neurodevelopment","description":"The cluster features dopamine biosynthetic and catabolic processes, neuron maturation, and neuron projection development, along with embryonic development terms, pointing to a role in neural development associated with dopamine metabolism rather than generic metabolism.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902114","count":3},{"id":"GO:0071320","count":3},{"id":"GO:0042416","count":3},{"id":"GO:0042551","count":3},{"id":"GO:0001701","count":3}]},{"hash":"2041989482185063634","title":"Plant metabolism and defense","description":"The top GO terms show core metabolism (fatty acid homeostasis; multiple amino acid and cofactor biosynthetic processes) together with plant-specific developmental and immune responses (fruit ripening and systemic acquired resistance via salicylic acid). This mix suggests a cohesive theme of plant metabolic pathways tied to defense and development rather than a single, isolated pathway.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055089","count":2},{"id":"GO:0006571","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0097053","count":2}]},{"hash":"804682611181517413","title":"Unknown","description":"The top GO terms are a mixed assortment (metabolic, immune differentiation, tissue development, ion transport, and assorted regulatory processes) with no clear, shared function tying the three proteins together. There isn\u2019t a coherent theme to justify a specific label, so Unknown is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008295","count":1},{"id":"GO:2001200","count":1},{"id":"GO:0043380","count":1},{"id":"GO:0007519","count":1},{"id":"GO:0070294","count":1}]},{"hash":"1787591609585581143","title":"Embryonic Development and Differentiation","description":"The GO terms point to broad developmental and organogenesis processes across tissues (left-right patterning, in utero development, eye and lens formation, hypothalamic migration, lung and goblet cell differentiation, neural precursor and T cell proliferation), suggesting a general theme of embryonic development rather than a single pathway.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:2000320","count":1},{"id":"GO:2000177","count":1},{"id":"GO:0035947","count":1},{"id":"GO:0043010","count":1}]},{"hash":"1150678826338886179","title":"Innate defense against Gram-positive bacteria","description":"Top GO terms point to detection of bacteria and innate immune defense, especially against Gram-positive bacteria, along with peptidoglycan turnover/catabolic processes and cell-wall related interactions. Together these terms suggest the proteins function in recognizing bacterial cell wall components and mounting host defense responses to Gram-positive pathogens.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009254","count":2},{"id":"GO:0016045","count":2},{"id":"GO:0044117","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0032827","count":2}]},{"hash":"404761953048947261","title":"Neuronal Excitability and Neurotransmission","description":"This cluster is dominated by GO terms for ion transport across membranes (potassium and sodium), membrane depolarization, and excitatory postsynaptic potentials, along with signaling related to serotonin receptors and dopamine secretion, pointing to neuronal excitability and synaptic neurotransmission. Some developmental terms exist (neural structures development), but the prevailing theme centers on neuronal ion-channel\u2013mediated signaling and neurotransmitter release.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0051899","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0060079","count":2},{"id":"GO:2001046","count":2}]},{"hash":"677862792182812847","title":"Unknown","description":"The top terms are scattered and many are obsolete, with no clear shared function tying the three proteins together. Terms span sporulation, various metabolic pathways (shikimate, one-carbon, triglyceride, pyridoxine biosynthesis) and inflammatory response, and there are no observed interactions (edges) among them, so a cohesive label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0030435","count":3},{"id":"GO:0071268","count":2},{"id":"GO:0019632","count":2},{"id":"GO:0000002","count":2}]},{"hash":"599718004649376573","title":"Ubiquitin-Dependent ERAD and Protein Ubiquitination","description":"The top GO terms are dominated by ubiquitin-related processes, notably ubiquitin-dependent ERAD pathway and protein polyubiquitination, which together point to ubiquitin-mediated protein quality control and degradation. The presence of several unrelated or obsolete terms suggests some annotation noise, but the core signal across the cluster appears to be ubiquitin tagging and ER-associated degradation. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0034198","count":2},{"id":"GO:0000463","count":1}]},{"hash":"143086023365224926","title":"Lipid metabolism and lysosome-mediated LDL clearance","description":"The GO terms point to lipid handling and clearance (cholesterol metabolism, triglyceride homeostasis, LDL particle clearance, response to LDL) and lysosomal targeting (protein targeting to lysosome) with amyloid-beta clearance, suggesting a cohesive role in lysosome-driven lipid processing and lipoprotein turnover.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902960","count":1},{"id":"GO:0006622","count":1},{"id":"GO:0097242","count":1},{"id":"GO:0002092","count":1},{"id":"GO:0070328","count":1}]},{"hash":"1177169047517725399","title":"Angiogenesis and vascular morphogenesis","description":"This cluster centers on terms tied to blood vessel formation and endothelial tube formation, including positive regulation of angiogenesis, VEGF signaling, and endothelial morphogenesis, with supporting ECM remodeling (collagen fibril organization). While there are some neurodevelopment terms present, the vascular development signals predominate, making the vascular morphogenesis theme the most representative. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":1},{"id":"GO:0021859","count":1},{"id":"GO:0030199","count":1},{"id":"GO:0001701","count":1},{"id":"GO:0006957","count":1}]},{"hash":"1382502977445730105","title":"Ergosterol and sphingolipid biosynthesis","description":"The top GO terms emphasize ergosterol biosynthesis, its regulation, unsaturated fatty acid and ether lipid metabolism, and sphingolipid (mannosyl-inositol phosphorylceramide) metabolism, pointing to a coherent lipid biosynthesis theme in fungal membranes. Some terms (nitrate assimilation, myelin maintenance) are less directly connected, but the strongest cluster signal is sterol/sphingolipid metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006675","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0006636","count":2}]},{"hash":"1216575032068570015","title":"Sugar and osmotic stress transport","description":"The GO terms cluster around membrane transport of sugars (fructose, glucose, trehalose) and other solutes, plus an osmotic stress response, suggesting these proteins function as transporters that help balance osmotic pressure by importing/sipping sugars and related solutes.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071332","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0006970","count":3},{"id":"GO:0015771","count":3},{"id":"GO:0019852","count":3}]},{"hash":"1497179877505067288","title":"Drosophila development and cell division","description":"GO terms cluster around Drosophila development (antenna and eye/sensory organ formation) and core cell-cycle events (meiotic/metaphase chromosome alignment, spindle assembly, cytokinesis) with ubiquitin-mediated protein turnover; together they point to developmental cell division processes in Drosophila.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051311","count":1},{"id":"GO:1990001","count":1},{"id":"GO:0048800","count":1},{"id":"GO:0045035","count":1},{"id":"GO:0045849","count":1}]},{"hash":"2260889988337275490","title":"Steroid Hormone Biosynthesis","description":"The proteins show enrichment for C21-steroid hormone metabolic and multiple steroid biosynthetic processes (estrogen, androgen, glucocorticoid), suggesting a cluster centered on steroidogenesis, with accompanying lipid biosynthesis aspects.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008207","count":3},{"id":"GO:0006703","count":3},{"id":"GO:0042761","count":3},{"id":"GO:0006710","count":3},{"id":"GO:0061370","count":3}]},{"hash":"1488660557113502003","title":"Genome Integration and Transposition","description":"The top GO terms highlight DNA transposition, DNA integration, and proviral latency, pointing to a function related to genome mobility and integration of mobile genetic elements (transposons/retroviruses) into the host genome, with some broader transcription and cell cycle context. This combination suggests a cohesive theme around genome integration processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042797","count":1},{"id":"GO:0032728","count":1},{"id":"GO:0006359","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0007059","count":1}]},{"hash":"2051284816613764496","title":"Embryonic organ development","description":"The top GO terms point to development of organs in the embryonic period across multiple tissues (lung, liver, digestive tract, in utero embryonic development), suggesting a shared role in embryogenesis and organ formation. While there are a few metabolism/immune-related terms mixed in, the dominant signal is embryonic organogenesis, making this a coherent label for the cluster given the small protein set.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048286","count":1},{"id":"GO:0046111","count":1},{"id":"GO:0048566","count":1},{"id":"GO:0070256","count":1},{"id":"GO:0043103","count":1}]},{"hash":"535586923091542875","title":"Metabolism and Protein Acetylation","description":"The top GO terms point to core biosynthetic and metabolic processes (mycothiol biosynthesis, arginine and glucosamine metabolism) alongside protein modification via acetylation (peptidyl-lysine and N-terminal acetylation). A few terms appear obsolete or unrelated (angiogenesis, sporulation), suggesting annotation noise, but the cluster seems centered on metabolic biosynthesis and regulation through acetylation. Confidence: Medium","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0060358","count":3},{"id":"GO:0017198","count":3},{"id":"GO:0006041","count":3}]},{"hash":"1257714851018690597","title":"P450-Mediated Xenobiotic Metabolism","description":"The strongest signals are xenobiotic-related processes and the epoxygenase P450 pathway, including xenobiotic catabolic process, organofluorine metabolism, and oxidative deethylation, pointing to a shared function in detoxification and metabolism of foreign compounds via cytochrome P450 enzymes. While other terms (potassium response, cell cycle regulation, etc.) appear. Overall, the theme is coherent but not exclusively tight, so confidence is Medium.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035865","count":3},{"id":"GO:1900087","count":3},{"id":"GO:0033072","count":3},{"id":"GO:0010760","count":3},{"id":"GO:0042738","count":3}]},{"hash":"2152108621380046021","title":"Unknown","description":"There is no shared GO signal or connectivity among the proteins (empty top terms, and edges/triangles are zero), so a common function cannot be inferred; thus the cluster is Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2262102715847320260","title":"Lymphoid immune development and NF-kB signaling","description":"The top GO terms cluster around lymph node development, T follicular helper cell differentiation, B cell homeostasis, and T cell proliferation, with activation of NF-kappaB signaling (NIK) and related pathways. Autophagy and apoptosis regulation also appear, which are commonly involved in lymphoid cell survival and immune activation. This combination suggests a coherent theme of adaptive immune development and signaling in lymphoid organs.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048535","count":2},{"id":"GO:0006914","count":2},{"id":"GO:0061470","count":2},{"id":"GO:0042981","count":2},{"id":"GO:0090073","count":2}]},{"hash":"1887598336980844291","title":"Ubiquitin-Mediated Immune Signaling","description":"The cluster is dominated by GO terms linking adaptive immune response and regulation of innate sensing (RIG-I), along with protein ubiquitination and autoubiquitination. This points to a common theme of ubiquitin-dependent control of immune signaling, with some neurotransmitter-related terms likely representing ancillary annotations rather than core cluster function. Overall, the primary signal is immune regulation via ubiquitination.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0039536","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0090263","count":1}]},{"hash":"354957705068379338","title":"Neurotransmitter signaling and synaptic excitability","description":"The top GO terms point to neuronal communication and excitability, including excitatory postsynaptic potential, serotonin/dopamine signaling, cholinergic synaptic transmission, and membrane depolarization. Developmental terms for brain structures are supplementary but still reflect neural pathway involvement, supporting a cohesive theme of neurotransmission and synaptic activity.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0007210","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0033603","count":2},{"id":"GO:0001988","count":2}]},{"hash":"299317474211267115","title":"Unknown","description":"The GO terms are highly heterogeneous with no single cohesive function across the proteins, spanning blood coagulation, eye morphogenesis, brown fat differentiation, synapse maintenance, and various signaling/regulatory processes. This mix does not support a clear, representative label beyond Unknown.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000860","count":1},{"id":"GO:0007596","count":1},{"id":"GO:0070543","count":1},{"id":"GO:2000584","count":1},{"id":"GO:0048593","count":1}]},{"hash":"1612152533032100747","title":"Immune response regulation and cytokine signaling","description":"This cluster's GO terms are dominated by immune-related processes: NK cell and cytotoxic T cell regulation, IL-4 production, and modulation of IL-1 signaling, plus tolerance induction. Although a few terms touch on nervous system development or VEGF signaling, the strongest common theme is immune response modulation and cytokine signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":1},{"id":"GO:0021740","count":1},{"id":"GO:0038033","count":1},{"id":"GO:0045404","count":1},{"id":"GO:0002859","count":1}]},{"hash":"2036819961479686412","title":"Immune-driven angiogenic remodeling","description":"This cluster shows terms tied to innate immunity (phagolysosome assembly, complement activation, leukocyte tethering) and to angiogenesis/vascular remodeling (positive regulation of sprouting angiogenesis, platelet activation), suggesting a shared theme of immune-mediated vascular changes. Some terms like embryonic development and thyroid hormone generation are broader but do not override the dominant immune-angiogenesis signals.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006590","count":2},{"id":"GO:0001845","count":2},{"id":"GO:0039573","count":2},{"id":"GO:0090050","count":2},{"id":"GO:0010572","count":2}]}]