{"hash":"696763563988587519","title":"Deubiquitinases regulate immune signaling","description":"The top GO terms show negative regulation of multiple immune signaling pathways (IL-8, IL-2, NOD1/2, CD40, death receptor signaling) and specific deubiquitination activities across several lysine linkages (K48, K29, K11, K6), pointing to a cluster of deubiquitinases modulating immune signaling. Despite only four proteins, the GO profile strongly supports a theme of immune-signal dampening by DUB activity.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_063710709.1","go_terms":["GO:1902042","GO:2000347","GO:2000349","GO:0071108","GO:0071947","GO:1990167","GO:0032495","GO:1990168","GO:0002385","GO:0002677","GO:0070433","GO:0035871","GO:0032691","GO:0043124","GO:0070536","GO:0032703","GO:2000352","GO:0001922","GO:0002634","GO:0034140","GO:0035523","GO:0034148","GO:0072573","GO:0044313","GO:0070429","GO:0032717","GO:0016567"]},{"accession":"XP_063722266.1","go_terms":["GO:0000722","GO:0090398","GO:0010082","GO:0000724","GO:0060250","GO:0080038","GO:0045842","GO:0032876","GO:1990683","GO:0071901","GO:0016925","GO:0034184"]},{"accession":"XP_063728375.1","go_terms":[]},{"accession":"XP_063725329.1","go_terms":["GO:0000470","GO:0006417","GO:0006412"]}],"graph":[],"all_go_terms":{"GO:0032717":1,"GO:1902042":1,"GO:0070433":1,"GO:0070429":1,"GO:2000349":1,"GO:0032703":1,"GO:0071108":1,"GO:0035523":1,"GO:0035871":1,"GO:0044313":1,"GO:0034148":1,"GO:0032495":1,"GO:0002677":1,"GO:0001922":1,"GO:0072573":1,"GO:0071947":1,"GO:0002385":1,"GO:0070536":1,"GO:0002634":1,"GO:1990168":1,"GO:2000352":1,"GO:0016567":1,"GO:0032691":1,"GO:0043124":1,"GO:1990167":1,"GO:0034140":1,"GO:2000347":1,"GO:0045842":1,"GO:1990683":1,"GO:0032876":1,"GO:0034184":1,"GO:0060250":1,"GO:0000722":1,"GO:0010082":1,"GO:0080038":1,"GO:0071901":1,"GO:0016925":1,"GO:0090398":1,"GO:0000724":1,"GO:0006412":1,"GO:0000470":1,"GO:0006417":1},"recipe_readded":["XP_063724692.1","XP_063719965.1","XP_063725895.1","XP_063723982.1","XP_063729136.1","XP_063725203.1","XP_063720168.1","XP_063717596.1","XP_063727205.1","XP_063725226.1","XP_063728634.1","XP_063711549.1","XP_063726955.1","XP_063728766.1","XP_063724284.1","XP_063729802.1","XP_063721108.1","XP_063721134.1","XP_063729798.1","XP_063714894.1"]}