{"hash":"1007342996507567600","title":"TLR-NFkB cytokine signaling cluster","description":"Most of the top GO terms point to innate immune signaling: TLR2 and TLR4 pathways with MyD88, NF-kB activation, and downstream cytokine production (e.g., IL-18, CCL5). The presence of terms for positive regulation of NF-kB signaling and TLR pathways supports a cohesive theme of Toll-like receptor\u2013driven immune responses and cytokine modulation. A few terms reference antifungal peptide production and translation or mitochondrial processes, which may reflect broader cellular readiness or housekeeping but do not define the cluster's primary function.","confidence":"High","size":12,"edges":31,"triangles":32,"max_degree":9,"top_function":null,"members":[{"accession":"XP_067947036.1","go_terms":["GO:0002755","GO:0045410","GO:2000340","GO:0070671","GO:0090073","GO:0034137","GO:2000494","GO:0032738","GO:0034145","GO:0002781","GO:0071651","GO:0071650","GO:0035669","GO:0070935","GO:0035665","GO:0043123"]},{"accession":"XP_067928847.1","go_terms":["GO:0009607","GO:0050884","GO:0097091","GO:0044381","GO:0060349","GO:0046597","GO:0035456","GO:0035455","GO:0030282","GO:0099638"]},{"accession":"XP_067932942.1","go_terms":[]},{"accession":"XP_067935212.1","go_terms":["GO:0006412"]},{"accession":"XP_067936398.1","go_terms":["GO:0006412"]},{"accession":"XP_067941745.1","go_terms":["GO:0046902","GO:0070940","GO:0030150","GO:1903740","GO:2000134","GO:0010867"]},{"accession":"XP_067942530.1","go_terms":["GO:0033617","GO:0009060"]},{"accession":"XP_067947848.1","go_terms":["GO:0006744","GO:1904808"]},{"accession":"XP_067951332.1","go_terms":["GO:0033617"]},{"accession":"XP_067933664.1","go_terms":["GO:0019878","GO:0009239","GO:0042759"]},{"accession":"XP_067935237.1","go_terms":["GO:0006450","GO:0006431","GO:0006438","GO:0006428","GO:0006429","GO:0006412","GO:0000372"]},{"accession":"XP_067949229.1","go_terms":["GO:0051341"]}],"graph":[["XP_067947848.1","XP_067949229.1",0.894],["XP_067935212.1","XP_067928847.1",0.503],["XP_067935212.1","XP_067932942.1",0.825],["XP_067935212.1","XP_067933664.1",0.663],["XP_067935212.1","XP_067935237.1",0.592],["XP_067935212.1","XP_067936398.1",0.614],["XP_067935212.1","XP_067942530.1",0.661],["XP_067935212.1","XP_067949229.1",0.726],["XP_067935212.1","XP_067951332.1",0.568],["XP_067947036.1","XP_067935237.1",0.884],["XP_067932942.1","XP_067933664.1",0.908],["XP_067932942.1","XP_067935237.1",0.955],["XP_067932942.1","XP_067951332.1",0.84],["XP_067928847.1","XP_067935237.1",0.846],["XP_067928847.1","XP_067942530.1",0.624],["XP_067928847.1","XP_067941745.1",0.809],["XP_067928847.1","XP_067936398.1",0.522],["XP_067928847.1","XP_067951332.1",0.841],["XP_067936398.1","XP_067935237.1",0.977],["XP_067936398.1","XP_067941745.1",0.753],["XP_067936398.1","XP_067942530.1",0.808],["XP_067936398.1","XP_067949229.1",0.898],["XP_067933664.1","XP_067935237.1",0.572],["XP_067933664.1","XP_067949229.1",0.505],["XP_067949229.1","XP_067941745.1",0.597],["XP_067949229.1","XP_067951332.1",0.856],["XP_067942530.1","XP_067935237.1",0.703],["XP_067942530.1","XP_067941745.1",0.649],["XP_067951332.1","XP_067935237.1",0.889],["XP_067951332.1","XP_067941745.1",0.561],["XP_067935237.1","XP_067941745.1",0.97]],"all_go_terms":{"GO:0071651":1,"GO:0043123":1,"GO:2000494":1,"GO:0002781":1,"GO:0071650":1,"GO:0034145":1,"GO:0002755":1,"GO:0034137":1,"GO:0045410":1,"GO:0070935":1,"GO:0035669":1,"GO:0032738":1,"GO:0035665":1,"GO:0090073":1,"GO:0070671":1,"GO:2000340":1,"GO:0009607":1,"GO:0097091":1,"GO:0030282":1,"GO:0060349":1,"GO:0050884":1,"GO:0046597":1,"GO:0035456":1,"GO:0099638":1,"GO:0044381":1,"GO:0035455":1,"GO:0006412":3,"GO:2000134":1,"GO:0030150":1,"GO:0070940":1,"GO:1903740":1,"GO:0046902":1,"GO:0010867":1,"GO:0009060":1,"GO:0033617":2,"GO:0006744":1,"GO:1904808":1,"GO:0009239":1,"GO:0042759":1,"GO:0019878":1,"GO:0000372":1,"GO:0006428":1,"GO:0006438":1,"GO:0006429":1,"GO:0006431":1,"GO:0006450":1,"GO:0051341":1},"recipe_readded":[]}