{"hash":"1465139504394124018","title":"p53-driven transcriptional stress and cell cycle control","description":"This cluster centers on stress-responsive regulation of transcription and translation, with a strong emphasis on the p53 signaling axis, cell cycle control, and protein stability. GO terms for p53-mediated signal transduction, cellular response to transcription inhibitors (actinomycin D), and regulation of the cell cycle, combined with ubiquitin-dependent protein turnover and stabilization, point to a coordinated module that links transcriptional stress to cell cycle regulation through ubiquitin pathways.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"members":[{"accession":"XP_060047877.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"XP_007524549.2","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"XP_007530989.1","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"XP_007538773.1","go_terms":["GO:0031564","GO:0045903","GO:0006353","GO:0006412","GO:1990145","GO:0046677","GO:0006351","GO:0045947","GO:0006437","GO:0034605","GO:0000455","GO:0042254"]}],"graph":[["XP_007530989.1","XP_060047877.1",0.614],["XP_007530989.1","XP_007524549.2",0.597],["XP_007530989.1","XP_007538773.1",0.746],["XP_060047877.1","XP_007538773.1",0.803],["XP_060047877.1","XP_007524549.2",0.767],["XP_007524549.2","XP_007538773.1",0.829]],"all_go_terms":{"GO:2000059":3,"GO:0032986":3,"GO:1901798":3,"GO:0050821":3,"GO:0006412":4,"GO:0072717":3,"GO:0071157":3,"GO:0071158":3,"GO:1904667":3,"GO:0045947":1,"GO:0006353":1,"GO:0006351":1,"GO:0034605":1,"GO:0006437":1,"GO:0046677":1,"GO:0031564":1,"GO:0042254":1,"GO:0000455":1,"GO:0045903":1,"GO:1990145":1},"recipe_readded":[]}