{"hash":"1312974259224873422","title":"ER Stress Response and Apoptosis Regulation","description":"The top GO terms cluster around cellular response to unfolded protein and ER stress, including regulatory aspects of intrinsic apoptotic signaling in response to stress, which together point to a theme of protein quality control and cell survival under stress. Some terms like DNA replication and iron-sulfur cluster assembly are less aligned with this theme and may reflect broader cellular maintenance roles of the proteins. Overall, the dominant signal is ER stress and apoptosis regulation, so this label captures the core function of the cluster.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","members":[{"accession":"XP_007529022.1","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_007538970.1","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_007537229.2","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_007517613.1","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_007531781.1","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_007540052.1","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_007521645.2","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]}],"graph":[["XP_007537229.2","XP_007517613.1",0.744],["XP_007537229.2","XP_007521645.2",0.78],["XP_007537229.2","XP_007529022.1",0.739],["XP_007537229.2","XP_007531781.1",0.854],["XP_007537229.2","XP_007538970.1",0.875],["XP_007537229.2","XP_007540052.1",0.751],["XP_007538970.1","XP_007517613.1",0.636],["XP_007538970.1","XP_007521645.2",0.844],["XP_007538970.1","XP_007529022.1",0.809],["XP_007538970.1","XP_007531781.1",0.767],["XP_007538970.1","XP_007540052.1",0.789],["XP_007521645.2","XP_007517613.1",0.748],["XP_007521645.2","XP_007529022.1",0.762],["XP_007521645.2","XP_007531781.1",0.75],["XP_007521645.2","XP_007540052.1",0.672],["XP_007531781.1","XP_007517613.1",0.717],["XP_007531781.1","XP_007529022.1",0.73],["XP_007531781.1","XP_007540052.1",0.665],["XP_007540052.1","XP_007517613.1",0.715],["XP_007540052.1","XP_007529022.1",0.62],["XP_007517613.1","XP_007529022.1",0.811]],"all_go_terms":{"GO:0034620":7,"GO:1903751":7,"GO:0006260":7,"GO:1903382":7,"GO:0016226":7,"GO:1900035":7,"GO:0000902":7,"GO:1902037":7,"GO:0031204":7,"GO:0070880":7,"GO:0070389":7,"GO:0006880":7,"GO:0090084":7,"GO:0000742":7,"GO:0006616":7},"recipe_readded":[]}