{"hash":"2015586399404923928","title":"Metal-Stress Ubiquitin-Proteasome Regulation","description":"This cluster centers on ubiquitin-mediated proteolysis, with several GO terms for protein ubiquitination, SCF-dependent proteasomal degradation, and ubiquitin-dependent catabolic processes. The metal-response terms (arsenic, cadmium, methylmercury) suggest a stress context in which ubiquitination regulates protein turnover to cope with metal toxicity. The circadian regulation and synapse assembly terms may reflect broader regulatory roles in cells and neurons, but the dominant signal is ubiquitin-proteasome\u2013mediated degradation, especially under metal stress.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"members":[{"accession":"XP_055901184.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_013071606.1","go_terms":[]},{"accession":"XP_055861568.1","go_terms":[]},{"accession":"XP_055862654.1","go_terms":["GO:0006226","GO:0006229","GO:0035863","GO:0009220","GO:0046081"]},{"accession":"XP_055891422.1","go_terms":[]},{"accession":"XP_055891449.1","go_terms":[]}],"graph":[["XP_055862654.1","XP_055901184.1",0.502],["XP_013071606.1","XP_055901184.1",0.526],["XP_055901184.1","XP_055861568.1",0.611],["XP_055901184.1","XP_055891422.1",0.53],["XP_055901184.1","XP_055891449.1",0.695]],"all_go_terms":{"GO:1902916":1,"GO:0046685":1,"GO:0071406":1,"GO:0071276":1,"GO:0031146":1,"GO:0030174":1,"GO:0042787":1,"GO:0060386":1,"GO:0042752":1,"GO:0000209":1,"GO:0031571":1,"GO:1903378":1,"GO:0000083":1,"GO:0006229":1,"GO:0035863":1,"GO:0046081":1,"GO:0006226":1,"GO:0009220":1},"recipe_readded":[]}