[{"hash":"1835329052457294730","title":"Cardiac calcium signaling and transcription regulation","description":"The cluster shows strong enrichment for cardiac-related processes (regulation of cardiac muscle contraction; cardiac hypertrophy in response to stress) and calcium signaling pathways (NFAT/calcineurin signaling; calcium transporter activity), along with transcription-related terms (RNA Pol II\u2013mediated transcription, DNA binding, nuclear import). This combination points to a cohesive module where calcium signaling interfaces with transcriptional regulation in cardiac muscle, despite some broad developmental terms present.","confidence":"High","size":29,"edges":325,"triangles":1954,"max_degree":28,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045944","count":8},{"id":"GO:0086004","count":7},{"id":"GO:0001824","count":7},{"id":"GO:0043588","count":7},{"id":"GO:0043388","count":7}]},{"hash":"1471268799303937294","title":"Neural and sensory system development","description":"The cluster is dominated by terms related to nervous system development, axonogenesis, visual perception, and sensory perception of pain, suggesting a cohesive theme of neural and sensory organ formation and function. While other terms touch on broader development (heart development, multicellular organism development) and some stress-related responses (glucose stimulus, dsRNA response), the strongest signal points to neural and sensory processes. ","confidence":"Medium","size":29,"edges":148,"triangles":337,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071333","count":11},{"id":"GO:0007601","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0043330","count":11},{"id":"GO:0007399","count":11}]},{"hash":"44868933619979162","title":"Neural development and innate immune signaling cluster","description":"The top GO terms reveal two connected themes: neural development and neural signaling (brain/forebrain development, neural tube closure, synaptic plasticity regulation, dopamine response) alongside innate immune processes (defense against Gram-positive bacteria, LPS signaling, innate immune response, LPS response, JNK cascade regulation). This suggests a group of proteins involved in cross-talk between neural development/signaling and immune pathways, rather than a single, purely neural or purely immune function. Despite no direct interactions in the edges, the functional annotations consistently point to a dual role in neurodevelopment and immune signaling.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0031663","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0048168","count":5}]},{"hash":"474392041258072222","title":"DNA replication and recombination","description":"Most terms cluster around DNA processing: DNA replication, DNA strand displacement, and reciprocal meiotic recombination, suggesting a genome maintenance theme. Some terms are obsolete or peripheral (glycosylation, chondroitin sulfate biosynthesis) or reflect stress responses, which may be incidental. Overall, the cluster appears to be centered on nucleic acid metabolism and genome integrity.","confidence":"Medium","size":29,"edges":15,"triangles":0,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0009636","count":4},{"id":"GO:0050853","count":3},{"id":"GO:0007519","count":3},{"id":"GO:0030206","count":3}]},{"hash":"43385805599796176","title":"Potassium Ion Transport and Membrane Potential","description":"The top GO terms cluster around intracellular potassium ion homeostasis, stabilization of membrane potential, and potassium ion transmembrane transport, pointing to proteins that regulate potassium flux and maintain membrane potential (i.e., potassium channels/transporters). Other terms like sensory perception or thermogenesis appear less central to this core function, so the dominant theme is potassium transport and membrane potential maintenance.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030007","count":6},{"id":"GO:0030322","count":6},{"id":"GO:0097623","count":5},{"id":"GO:1990573","count":5},{"id":"GO:0002024","count":5}]},{"hash":"643316773237931854","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":392,"triangles":3335,"max_degree":28,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":25},{"id":"GO:0031047","count":25},{"id":"GO:0048701","count":16},{"id":"GO:0006260","count":16},{"id":"GO:0000398","count":16}]},{"hash":"66221495617405621","title":"Thermo-sensory GPCR signaling cluster","description":"The top GO terms indicate strong enrichment for temperature-related processes (diet-induced thermogenesis, cellular response to temperature stimulus) and GPCR-mediated signaling (positive regulation of GPCR signaling, dopamine receptor signaling, acetylcholine metabolism), with additional cues from prostaglandin signaling and immune response. This suggests a group of proteins involved in stimulus-triggered, GPCR-based signaling that connects thermosensation and neurochemical communication with immune context, rather than a single, narrow function. ","confidence":"Medium","size":29,"edges":171,"triangles":176,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0001991","count":15},{"id":"GO:0007195","count":15}]},{"hash":"1076783796101645975","title":"Immune Signaling and Developmental Pathways","description":"The cluster centers on immune-related signaling (T cell receptor signaling and B cell differentiation) alongside developmental signaling (Wnt and ephrin pathways, prostaglandin response, morphogenesis, and apoptosis execution), suggesting a cohesive theme of signal transduction guiding immune activation and tissue development.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":23},{"id":"GO:0050852","count":23},{"id":"GO:0048013","count":23},{"id":"GO:0090263","count":23},{"id":"GO:0097194","count":21}]},{"hash":"380209153327692501","title":"Developmental Signaling and Differentiation","description":"The top GO terms cluster around developmental processes (forebrain development, skin development, prostate glandular differentiation, single fertilization) and regulatory signaling (positive regulation of GTPase activity, TORC1 signaling), suggesting a theme of development-linked signaling pathways. The terms are diverse, including reproduction, hypoxia response, and meiosis regulation, which indicates a broad developmental/signaling cluster rather than a tightly focused single function. Confidence reflects this moderate cohesion across multiple developmental and signaling processes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0043547","count":11},{"id":"GO:1904263","count":11},{"id":"GO:0007338","count":11},{"id":"GO:0043588","count":10},{"id":"GO:0071456","count":10}]},{"hash":"1216542745670816356","title":"RNA processing and translation regulation","description":"These proteins show strong enrichment for post-transcriptional control functions: regulation of mRNA splicing via the spliceosome (both positive and negative), regulation of mRNA stability in response to stress, poly(A) tail regulation, and regulation of translational initiation, plus ncRNA-mediated gene silencing. Together, these terms point to a cohesive role in RNA processing and controlling translation under stress.","confidence":"High","size":29,"edges":41,"triangles":19,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0031047","count":20},{"id":"GO:0048026","count":20},{"id":"GO:0048025","count":19},{"id":"GO:0060211","count":18}]},{"hash":"789524010629499481","title":"Neural GPCR Signaling and Perception","description":"The top GO terms cluster around nervous system development and function, including enteric nervous system development, visual perception, morphine response, and prepulse inhibition, all pointing to neuronal signaling and sensory processing. The notable mention of G protein-coupled receptor internalization reinforces a GPCR-mediated signaling theme, common in neural communication. Prostaglandin signaling and regulation of interleukin-1 beta production appear as ancillary, but the dominant signal is neural GPCR signaling and sensory perception.","confidence":"High","size":29,"edges":53,"triangles":45,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048484","count":4},{"id":"GO:0043388","count":4},{"id":"GO:0071380","count":3},{"id":"GO:0032651","count":3},{"id":"GO:0002024","count":3}]},{"hash":"911495595952479284","title":"Unknown","description":"The GO terms are highly diverse, spanning development (hippocampus and atrial septum morphogenesis), chromatin/nucleosome assembly, spindle organization, transcription, and even immune isotype switching. There isn\u2019t a single clear biological function or pathway linking the majority of proteins, so a cohesive cluster function cannot be inferred from these terms.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0048298","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0003290","count":2},{"id":"GO:0006334","count":2}]},{"hash":"1947497516341180114","title":"Rho GTPase-driven actin remodeling and migration","description":"These proteins converge on Rho GTPase signaling and actin cytoskeleton remodeling, highlighted by lamellipodium/filopodium assembly, actin crosslinking, and cell migration. The top GO terms repeatedly reflect regulation of Rho signaling, GTPase activity, and actin dynamics, indicating a cohesive role in cytoskeletal remodeling and motility. Some terms (heart development, grooming behavior) may reflect broader developmental or behavioral contexts of these pathways.","confidence":"High","size":29,"edges":20,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0046328","count":3},{"id":"GO:2000821","count":3}]},{"hash":"1779295480810739936","title":"Nephron and vascular morphogenesis","description":"The cluster's top GO terms show strong emphasis on metanephric distal/proximal tubule development, mesonephric duct development, and lymph vessel morphogenesis, pointing to kidney nephron formation and associated vasculature. While there are ancillary terms related to cartilage condensation and immune interactions, the kidney/nephron development signal is dominant.","confidence":"High","size":29,"edges":11,"triangles":2,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":27},{"id":"GO:0001502","count":18},{"id":"GO:0010572","count":17},{"id":"GO:0036303","count":16},{"id":"GO:0072287","count":16}]},{"hash":"1404670422183230363","title":"Embryonic development and tissue differentiation","description":"The GO terms point to multiple embryonic differentiation programs across skeletal, neural, and cardiac tissues (cartilage and cranial skeleton morphogenesis, endocardial and lens differentiation, trigeminal nerve development), with BMP signaling and transcriptional regulation also represented. While spliceosome assembly is noted, the prevailing pattern centers on vertebrate organogenesis and tissue specification, suggesting this cluster reflects developmental differentiation processes.","confidence":"High","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0051216","count":2},{"id":"GO:0048701","count":2}]},{"hash":"1257303227834260073","title":"Developmental signaling and transcription regulation","description":"This cluster features terms tied to development (hair follicle morphogenesis, trophoblast giant cell differentiation) alongside transcriptional control (DNA-templated transcription, RNA polymerase II\u2013mediated transcription) and signals like calcium and growth processes, suggesting proteins that coordinate developmental signaling with gene expression. Some terms are broad, but the overall theme is development-linked transcriptional regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0007204","count":3},{"id":"GO:0016049","count":3},{"id":"GO:2000134","count":2}]},{"hash":"1615253338100979387","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"The cluster is dominated by terms related to excitatory synaptic signaling, including glutamatergic transmission, excitatory postsynaptic potentials, calcium ion transport, and regulation of short- and long-term synaptic plasticity, which together point to proteins functioning in neuronal communication and plasticity. A few terms (e.g., angiogenesis) are less directly aligned but do not override the main neuronal theme.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0007205","count":3},{"id":"GO:0048172","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0045766","count":3}]},{"hash":"1224223260548631436","title":"Lectin-mediated immune signaling","description":"This cluster is dominated by GO terms for the lectin-based immune response, including complement activation via the lectin pathway and stimulatory C-type lectin receptor signaling, along with leukocyte recruitment features (tethering/rolling). These together point to a coherent theme of lectin-mediated innate immune activation. The kidney/developmental terms (nephrogenesis, mesonephric duct morphogenesis) appear incidental to the main signal, so the central function is lectin-driven immunity.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":16},{"id":"GO:0002223","count":16},{"id":"GO:0036303","count":15},{"id":"GO:0072287","count":15},{"id":"GO:0010572","count":15}]},{"hash":"1113353721808568664","title":"Metanephric kidney morphogenesis","description":"The top GO terms are dominated by metanephric and mesonephric development (distal tubule morphogenesis, proximal tubule development, mesonephric duct development, etc.), indicating a cohesive theme of renal morphogenesis. Immune-related terms (complement activation, leukocyte tethering) appear among the top terms but are less representative of the cluster's core signal. Overall, the proteins are best characterized as involved in nephron/renal structure formation, hence the label Metanephric kidney morphogenesis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":20},{"id":"GO:0071226","count":17},{"id":"GO:0036303","count":15},{"id":"GO:0072287","count":15},{"id":"GO:0010572","count":15}]},{"hash":"532721049944204096","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":15},{"id":"GO:0033280","count":14},{"id":"GO:0042787","count":12},{"id":"GO:0030433","count":10},{"id":"GO:1903265","count":9}]},{"hash":"519608978284589567","title":"Steroid and vitamin D hormone biosynthesis","description":"These proteins appear enriched for biosynthesis of steroid hormones (aldosterone, cortisol, progesterone) and calcitriol (vitamin D), plus retinoid-related metabolism. The presence of epoxygenase P450 pathways and related monooxygenase activity supports a lipid-signaling/hormone biosynthesis theme, with sex differentiation as a downstream relevance. Overall, the cluster centers on steroid and vitamin D hormone production and related P450-mediated metabolism.","confidence":"High","size":29,"edges":24,"triangles":11,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0019383","count":29},{"id":"GO:2001037","count":29},{"id":"GO:0042904","count":29},{"id":"GO:0032342","count":29},{"id":"GO:0010193","count":29}]},{"hash":"1558112565778209889","title":"Blood coagulation, fibrinolysis, and complement activation","description":"The top GO terms are dominated by coagulation (blood coagulation, plasminogen activation, fibrinolysis) and complement activation (classical and lectin pathways), pointing to a vascular/hemostatic and innate immune function for this cluster. While there are also terms for Wnt signaling and midbrain development, which may reflect broader regulatory roles of some proteins, the strongest, most cohesive signal centers on coagulation and complement pathways.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0045766","count":6},{"id":"GO:0042730","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0031639","count":6}]},{"hash":"1705717536361375421","title":"Unknown","description":"The GO terms span a mix of biosynthetic processes (antibiotic, biotin, cobalamin), various catabolic pathways (triglyceride, 3-phenylpropionate, uracil), oxidative detoxification, and even brain development, with no clear, single functional theme dominating the cluster. This heterogeneity makes a cohesive, intuitive label unlikely.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0009102","count":6},{"id":"GO:0007420","count":5},{"id":"GO:0042952","count":5},{"id":"GO:0019433","count":5}]},{"hash":"1240349823571175375","title":"Cell adhesion and motility signaling","description":"The most represented GO terms are cell-matrix adhesion, platelet aggregation, lamellipodium assembly, and ephrin receptor signaling, all pointing to adhesion interfaces and actin-driven motility and signaling. While other terms touch development and morphogenesis, the core theme across the frequent terms is adhesion-related interactions and migratory signaling, suggesting the cluster centers on proteins involved in cell\u2013matrix adhesion and cytoskeletal dynamics.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0070527","count":4},{"id":"GO:0021526","count":3},{"id":"GO:0030032","count":3},{"id":"GO:2000346","count":3}]},{"hash":"1450373967272922596","title":"Drosophila oogenesis and embryonic morphogenesis","description":"These terms collectively point to developmental processes during Drosophila oogenesis and embryogenesis, including follicle cell polarity and adhesion, BMP signaling, and germ layer formation, with eye development also represented. The cluster thus reflects morphogenesis and developmental signaling in insects, centered on the egg chamber/embryo context, despite a few outliers. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001744","count":4},{"id":"GO:0075015","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0007299","count":4},{"id":"GO:0045948","count":2}]},{"hash":"422012147892846547","title":"Lipid biosynthesis and fatty acid metabolism","description":"The top GO terms cluster around lipid-related processes: lipoteichoic acid biosynthesis, fatty acid biosynthesis, long-chain fatty acid metabolism, bile acid metabolism, and acetyl-CoA\u2013related biosynthetic steps, pointing to a lipid-centric metabolic theme. Some terms like seed germination or phenylpropanoid metabolism may reflect broader metabolic annotations or cross-species signals, but the dominant pattern supports lipid biosynthesis and fatty acid processing as the core function of this cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":5},{"id":"GO:0006633","count":4},{"id":"GO:0010030","count":4},{"id":"GO:0019654","count":4},{"id":"GO:0090410","count":4}]},{"hash":"678255025695920928","title":"Embryonic Kidney Development","description":"Most of the top GO terms point to metanephric/mesonephric tubule and duct development, i.e., kidney organogenesis, with supporting vascular and immune-related morphogenesis terms. The kidney development signals dominate, making this a coherent label for the cluster.","confidence":"High","size":29,"edges":21,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":25},{"id":"GO:0036303","count":24},{"id":"GO:0072287","count":24},{"id":"GO:0072218","count":24},{"id":"GO:0090403","count":24}]},{"hash":"1433631067812235805","title":"Developmental Regulation and Apoptosis","description":"Most top GO terms center on development (roof of mouth development, multicellular organism development) and regulation of cell fate and apoptosis (positive regulation of thymocyte apoptotic process, extrinsic apoptotic signaling). While some terms touch on stress responses or protease/coagulation regulation, the dominant theme appears to be developmental processes and their regulation. Therefore, this label captures the cluster\u2019s overall functional emphasis, albeit with some heterogeneity.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":4},{"id":"GO:0001558","count":3},{"id":"GO:0050819","count":3},{"id":"GO:0060021","count":2},{"id":"GO:0070245","count":2}]},{"hash":"1774961740497539764","title":"Chloroplast ribosome biogenesis and translation","description":"This cluster's dominant terms point to chloroplast protein synthesis machinery, with ribosome biogenesis and small subunit biogenesis, plus protein targeting to chloroplast and tRNA modification supporting translation. Other terms (cell cycle, glucose catabolism, stress responses) are less central, so the core theme is chloroplast ribosome assembly and translation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007049","count":9},{"id":"GO:0039707","count":7},{"id":"GO:0006007","count":7},{"id":"GO:0045036","count":7},{"id":"GO:0006400","count":6}]},{"hash":"905010215642207105","title":"Osteoclast differentiation and immune signaling","description":"The cluster centers on osteoclast differentiation, immune responses (LPS signaling, Gram-positive defense, IL-8), and cytoskeletal/podosome remodeling (actin organization, podosome assembly) with membrane localization and NO production, indicating a combined osteoclast/macrophage inflammatory signaling theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0031663","count":10},{"id":"GO:0071260","count":9},{"id":"GO:0030316","count":9},{"id":"GO:0050830","count":9},{"id":"GO:0045416","count":9}]},{"hash":"1002194010496634524","title":"Neuronal projection development and microtubule dynamics","description":"The cluster is dominated by GO terms related to axonogenesis, neuron projection development, and cytoskeletal microtubule organization, including both positive and negative regulation of microtubule polymerization/depolymerization, which together point to roles in neurite outgrowth and axonal development. Additional terms about nerve growth factor response and Rac signaling modulation support a neuronal signaling context that ties cytoskeletal dynamics to projection growth. Despite one intron-splicing term present, the prevailing pattern is neuronal projection development coupled with microtubule regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000372","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0031115","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0031175","count":2}]},{"hash":"596089365347430701","title":"Neuronal ion transport and signaling","description":"Top GO terms cluster around ion transmembrane transport (sodium, potassium, calcium), membrane depolarization, and synaptic signaling (excitatory postsynaptic potential and GABA signaling). The accompanying behavioral terms (startle response, locomotory behavior, circadian sleep/wake regulation) suggest involvement in neural circuits controlling movement, arousal, and sleep; collectively these proteins appear linked to neuronal excitability and neurotransmission.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":20},{"id":"GO:0060079","count":19},{"id":"GO:0071805","count":19},{"id":"GO:0098703","count":17},{"id":"GO:0045188","count":17}]},{"hash":"2171740724747258197","title":"Kinase signaling regulation and cell proliferation","description":"The top GO terms converge on regulation of signaling and kinase activity (positive/negative regulation of protein kinases, GTPase activity), along with mitotic cell cycle and proliferation. While a few terms (hypoxia response, mRNA transport, myelination) are broader, the dominant theme is regulated signal transduction driving cell growth and division, including autophosphorylation events. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":11},{"id":"GO:0071456","count":9},{"id":"GO:0051028","count":9},{"id":"GO:0071902","count":9},{"id":"GO:0000278","count":9}]},{"hash":"135259780610385329","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":132,"triangles":243,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015991","count":8},{"id":"GO:0016477","count":7},{"id":"GO:0043065","count":7},{"id":"GO:0008285","count":7},{"id":"GO:0090090","count":7}]},{"hash":"1149060924136709351","title":"Ubiquitination and NF-\u03baB/TNF Signaling","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes and various forms of ubiquitination (mono-, poly-, autoubiquitination, including K6-linked), indicating a core role in ubiquitin tagging and protein turnover. It also connects to inflammatory signaling pathways (NF-\u03baB, TNF) and innate immune signaling (NOD2), with a contextual note on vitamin D response, suggesting these proteins participate in regulating immune responses via ubiquitination. Overall, the theme is ubiquitination machinery coupled to inflammatory signaling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0016567","count":8},{"id":"GO:0032088","count":6},{"id":"GO:0070431","count":6},{"id":"GO:1903265","count":6}]},{"hash":"495164695003292271","title":"Ubiquitin-Proteasome-Mediated Proteolysis","description":"This cluster centers on ubiquitin-dependent proteolysis (ubiquitin-dependent protein catabolic process, protein polyubiquitination, SCF-dependent proteasomal degradation). The strong enrichment for these terms indicates proteins function together to tag substrates for proteasomal degradation, a core mechanism regulating cell-cycle events and oocyte maturation, with additional stress-related regulation (cadmium response). Overall, a cohesive ubiquitin-proteasome degradation module.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0000209","count":13},{"id":"GO:0031146","count":11},{"id":"GO:0071276","count":10},{"id":"GO:0042752","count":10}]},{"hash":"819995823444018783","title":"Mitochondrial respiration and gene expression","description":"The top GO terms include mitochondrial electron transport (NADH to ubiquinone) and core gene expression processes (DNA-templated transcription and translation), plus transcription regulation. This pattern suggests a cluster of proteins tied to energy production and the machinery of gene expression, possibly reflecting nuclear-encoded factors interfacing with mitochondrial function and general transcription/translation apparatus. While a few terms are less central (e.g., zinc response, TGF-beta signaling), they do not override the dominant theme. Confidence: High","confidence":"","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006120","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006412","count":2}]},{"hash":"941414242851005709","title":"Neuronal Exocytosis and Synaptic Transmission","description":"The cluster is dominated by GO terms for neurotransmitter secretion, exocytosis, and synaptic transmission (glutamatergic), indicating a theme of vesicle-mediated neuronal communication. Additional terms point to broader signaling regulation (NF-kappaB signaling, protein dephosphorylation) and cell morphology, but the core signal centers on neuronal secretory and synaptic processes, with some terms representing linked or ancillary pathways.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007269","count":5},{"id":"GO:0010838","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0051968","count":4},{"id":"GO:0007205","count":4}]},{"hash":"1196465779361830341","title":"Immune and developmental signaling","description":"The top GO terms cluster around immune signaling (T cell receptor signaling, B cell differentiation) and cell\u2013cell communication (integrin and ephrin receptor signaling) with development-related pathways (Wnt signaling, branching morphogenesis), suggesting a group of proteins involved in intercellular signaling during immune development and tissue morphogenesis. Some terms like apoptotic process and potassium ion transport are present but appear peripheral to the main theme.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":18},{"id":"GO:0050852","count":18},{"id":"GO:0048013","count":17},{"id":"GO:0090263","count":17},{"id":"GO:0006915","count":16}]},{"hash":"1667432626768964570","title":"Fatty acid and bile acid metabolism","description":"The proteins cluster around fatty acid biosynthesis and related lipid pathways\u2014long-chain and medium-chain fatty-acyl-CoA metabolism, and bile acid metabolism\u2014indicating a cohesive lipid metabolism module. A few unrelated terms exist, but the dominant signal supports a fatty acid-centric function.","confidence":"High","size":28,"edges":18,"triangles":1,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:1902987","count":8},{"id":"GO:0036112","count":8},{"id":"GO:0006633","count":7},{"id":"GO:0010030","count":7},{"id":"GO:0019654","count":7}]},{"hash":"1209697333122399077","title":"GPCR-cAMP Blood Pressure Signaling","description":"The cluster is enriched for GPCR pathways that activate or inhibit adenylate cyclase and downstream cAMP signaling, including dopamine and acetylcholine regulation, with strong ties to blood pressure control via renin-angiotensin and prostaglandin responses; immune and gut-development terms are present but secondary.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":28},{"id":"GO:0010579","count":28},{"id":"GO:0022900","count":28},{"id":"GO:0007190","count":28},{"id":"GO:0001991","count":24}]},{"hash":"1104955294817211565","title":"RNA splicing regulation and translation initiation","description":"The top terms cluster around post-transcriptional control of gene expression: spliceosome-mediated and alternative mRNA splicing, ncRNA-mediated gene silencing, regulation of translational initiation, and formation of the translation preinitiation complex, with auxiliary connections to mRNA tail shortening. This points to a cohesive theme of RNA processing and translation control rather than functions like immune signaling. ","confidence":"High","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0043029","count":4},{"id":"GO:0033280","count":4}]},{"hash":"431407668971531074","title":"Renin-angiotensin\u2013GPCR Cardiovascular Signaling","description":"The top terms cluster around cardiovascular regulation (blood pressure via renin-angiotensin, vascular smooth muscle differentiation), GPCR signaling and related pathways (dopamine and acetylcholine signaling, prostaglandin response), with additional immune-related terms, suggesting a theme of GPCR-mediated cardiovascular signaling with inflammatory modulation. Confidence: Medium","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":26},{"id":"GO:0007195","count":26},{"id":"GO:0060408","count":26},{"id":"GO:0007497","count":26},{"id":"GO:0006955","count":26}]},{"hash":"451413605199927153","title":"Multicellular Development and Calcium Signaling","description":"The cluster shows enrichment in developmental processes across tissues (lung and placenta development, multicellular organism development) and several calcium-related signaling activities (positive regulation of calcium-mediated signaling, calcium ion import). This pattern suggests a cohesive theme around developmental regulation guided by calcium signaling pathways. Some terms like long-term synaptic potentiation and manganese transport are ancillary but fit within broader signaling and metal ion transport roles in cells.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046638","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0050850","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0098703","count":3}]},{"hash":"132945235038718491","title":"Myeloid Immune Cell Differentiation","description":"Based on GO terms like myeloid progenitor cell differentiation, dendritic cell cytokine production, mast cell differentiation, and innate immune response, the cluster is best characterized by differentiation and activity of myeloid-derived immune cells and their innate signaling. Some development terms are present but are secondary to the immune differentiation theme.","confidence":"High","size":28,"edges":3,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002318","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0002371","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0060484","count":3}]},{"hash":"372868060575748403","title":"DNA Damage Response and Inflammatory Signaling","description":"The cluster\u2019s top GO terms center on stress-responsive signaling and transcriptional regulation, including p53-mediated apoptotic signaling in response to DNA damage, TNF and NF-kB pathways, and responses to lipopolysaccharide and ischemia. There is also a theme of transcriptional control and RNA processing, suggesting these proteins participate in coordinating DNA damage responses with inflammatory signaling and gene expression programs. Confidence: Medium","confidence":"","size":28,"edges":285,"triangles":1467,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042771","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0033209","count":3},{"id":"GO:0042347","count":3},{"id":"GO:0034051","count":3}]},{"hash":"2043193308961623071","title":"Neural tube and organ morphogenesis","description":"This cluster is strongly enriched for embryonic development terms: neural tube patterning and closure, forebrain morphogenesis, dorsal/ventral neural tube patterning, cochlea morphogenesis, heart looping, and negative regulation of cardiac muscle differentiation. Epithelial-mesenchymal signaling also supports morphogenesis processes. While a few terms relate to xenobiotic or prostaglandin responses, the dominant pattern points to coordinated tissue patterning and organ morphogenesis during development.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0021904","count":2},{"id":"GO:0071380","count":2},{"id":"GO:2000726","count":2},{"id":"GO:0090103","count":2}]},{"hash":"1051681358859357980","title":"Mitochondrial Translation and Metabolic Pathways","description":"Dominant GO term is mitochondrial translation, with eight proteins annotated to GO:0032543, suggesting the cluster centers on mitochondrial protein synthesis. Additional terms point to related metabolic processes (fatty acid catabolism, transamidation for tRNA biosynthesis) and organelle organization, which together imply a mitochondria-focused set involved in translation and energy metabolism. Some terms are obsolete or broad (nylon catabolic process, photosynthesis), but the core signal remains mitochondrial translation and linked metabolic functions.","confidence":"High","size":28,"edges":38,"triangles":14,"max_degree":9,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0032543","count":8},{"id":"GO:0009097","count":6},{"id":"GO:0019878","count":5},{"id":"GO:0009791","count":5},{"id":"GO:0009062","count":5}]},{"hash":"1326849591420501358","title":"Innate immune signaling and cellular stress response proteins","description":"The top GO terms show clear enrichment for innate immunity and defense against Gram-positive bacteria, including TLR4 signaling, suggesting a core immune signaling function; additional stress-response terms (cadmium, UV-A) indicate a broader cellular stress response role, while many other terms are peripheral. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0071492","count":3},{"id":"GO:0003016","count":3}]},{"hash":"2017290221738847530","title":"Ribosome biogenesis and rRNA maturation","description":"The dominant GO terms are about maturation and biogenesis of ribosomal RNA subunits (SSU/LSU) and overall ribosome assembly, including mRNA capping and export as supporting RNA processing steps. This points to a coherent theme of ribosome production and RNA maturation, with one outlier term (male gonad development) that appears less connected to the core function.","confidence":"High","size":28,"edges":4,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0000466","count":5},{"id":"GO:0006370","count":4},{"id":"GO:0006406","count":4}]},{"hash":"1395522423947021763","title":"Immune signaling and axon guidance proteins","description":"The GO terms span adaptive immune processes (T cell selection, helper T cell enhancement) and neural development/axon guidance (branchiomotor neuron axon guidance, semaphorin-plexin signaling), suggesting a shared theme around signaling and adhesion used by both immune cells and neurons. Therefore, labeling this cluster as immune signaling and axon guidance proteins reflects the dual functional theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045058","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0035397","count":2},{"id":"GO:0021785","count":2},{"id":"GO:0007413","count":2}]},{"hash":"1985051463009910162","title":"P450-Mediated Xenobiotic and Hormone Metabolism","description":"Top terms center on xenobiotic catabolic processes (coumarin, carbazole, camphor) and hormone biosynthesis (retinoic acid, aldosterone, progesterone), plus the epoxygenase P450 pathway. This points to a cluster enriched in cytochrome P450\u2013related metabolic functions bridging xenobiotic processing and steroid/hormone biosynthesis, with a few developmental terms likely annotations spillover. Overall, a cohesive theme is present but not exclusively restricted to a single process.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046226","count":5},{"id":"GO:0046232","count":5},{"id":"GO:0060065","count":5},{"id":"GO:0019383","count":4},{"id":"GO:2001037","count":4}]},{"hash":"517859838222449351","title":"Multicellular Development and Morphogenesis","description":"The top GO terms point to broad developmental processes across tissues (skin, forebrain, skeletal system, neural tube closure) and general multicellular growth, with supporting roles in transcriptional regulation and ubiquitin-mediated proteostasis, suggesting a cluster of proteins involved in development and tissue morphogenesis with regulatory coordination. However, the presence of ubiquitination and ERAD-related terms indicates additional regulatory layers beyond a single developmental pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0035264","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0000209","count":3}]},{"hash":"1196350451851055583","title":"Small GTPase signaling and cAMP regulation","description":"The top GO terms cluster around small GTPase-mediated signaling and cAMP-related regulation (Ras signaling, cAMP response, and PKA activity modulation), suggesting a module focused on intracellular signaling control. Additional terms like sarcomere organization and bud neck localization may reflect broader cytoskeletal and cell-cycle coordination linked to GTPase regulators.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":4},{"id":"GO:0042391","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0071320","count":3},{"id":"GO:0046580","count":3}]},{"hash":"122562554853470894","title":"Immune activation and renal morphogenesis","description":"The top GO terms cluster around immune/ inflammatory signals (complement activation via lectin pathway, platelet activation, leukocyte tethering/ rolling, response to fungal origin) alongside terms for metanephric/mesonephric development and lymph vessel morphogenesis, suggesting a theme that combines immune activation with kidney/urinary tract and lymphatic organ development. Some oxidative stress and senescence terms are present as well, but the dominant pattern ties immune signaling to renal/lymphatic morphogenesis.","confidence":"Medium","size":28,"edges":11,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":21},{"id":"GO:0010572","count":20},{"id":"GO:0071226","count":20},{"id":"GO:0036303","count":19},{"id":"GO:0072287","count":19}]},{"hash":"2154084013751764132","title":"Ribosome biogenesis and RNA modification","description":"The cluster is dominated by GO terms for ribosome biogenesis, cytoplasmic translation, and various RNA-processing activities (tRNA modification, RNA Pol III transcription, and pseudouridine synthesis). This suggests a core function in ribosome assembly and RNA metabolism, with a few peripheral terms (metal ion transport and microvillus assembly) likely representing secondary roles or housekeeping associations. Therefore, the label emphasizes the RNA/ribosome-centric nature of the cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0002181","count":3},{"id":"GO:0006400","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0042797","count":3}]},{"hash":"1033002128935806022","title":"RNA processing and translation initiation regulation","description":"The terms center on RNA processing and mRNA fate (stability, polyadenylation, tail shortening, splicing) and on translation initiation, including preinitiation complex formation and IRES-initiated translation, indicating a shared RNA metabolism/translation-control theme.","confidence":"High","size":28,"edges":374,"triangles":3176,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":19},{"id":"GO:0006378","count":17},{"id":"GO:1901407","count":16},{"id":"GO:0060211","count":15},{"id":"GO:0006446","count":15}]},{"hash":"2007741967701541714","title":"TLR signaling and inflammatory cytokine production","description":"These GO terms cluster around Toll-like receptor signaling and downstream inflammatory responses, including MyD88-dependent TLR signaling, TLR4/8/10 pathways, dsRNA response, diacyl lipopeptide detection, and positive regulation of IL-6, IL-18, and IFN-\u03b2. Collectively they point to innate immune sensing and initiation of inflammation, suggesting the proteins form a TLR-driven signaling module regulating cytokine production.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002755","count":16},{"id":"GO:0045410","count":16},{"id":"GO:0034166","count":14},{"id":"GO:0034158","count":14},{"id":"GO:0045359","count":14}]},{"hash":"42298100742526374","title":"Developmental Signaling and ECM Remodeling","description":"These proteins show notable enrichment for developmental signaling (Wnt signaling, angiogenesis, amelogenesis) and extracellular matrix remodeling (ECM disassembly, collagen catabolic process), pointing to roles in tissue development and morphogenesis. While translation-related terms appear, they do not define the cluster\u2019s primary function, which seems driven by development and matrix remodeling. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060211","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0031047","count":2}]},{"hash":"683957559835416427","title":"Glycan biosynthesis and cell-surface development","description":"The top GO terms cluster around glycosylation and carbohydrate biosynthesis (arabinogalactan protein metabolism, O-linked glycosylation via hydroxyproline, poly-N-acetyllactosamine biosynthesis, Lewis a epitope biosynthesis) and several development-related processes involving cell surface structures and tissue polarity/adhesion (follicle epithelium polarity, follicle cell adhesion, root hair development, insect visual primordium formation, seed coat mucilage). This suggests a coherent theme where glycan modification and glycoprotein components influence cell surface properties and developmental processes across species.","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":10},{"id":"GO:0001744","count":9},{"id":"GO:0042248","count":9},{"id":"GO:0007299","count":9},{"id":"GO:0080147","count":7}]},{"hash":"2074436260014491824","title":"Placental and embryonic morphogenesis","description":"The dominant terms (trophoblast giant cell differentiation, placental development, cartilage morphogenesis, left/right pattern formation, endocrine system development) point to embryonic development and tissue morphogenesis with a strong emphasis on placenta-related processes. Some additional terms about RNA splicing and transcription regulation likely reflect general developmental gene control rather than a distinct function, but they do not override the core theme. Thus the cluster is best described as placental and embryonic morphogenesis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":24},{"id":"GO:0060806","count":24},{"id":"GO:0060536","count":24},{"id":"GO:0035270","count":24},{"id":"GO:0060972","count":24}]},{"hash":"2221773023310982545","title":"Neural development and signaling regulators","description":"The cluster features GO terms tied to brain development, glutamatergic synaptic transmission, and regulation of signaling pathways (notably Rho-mediated), plus associated processes like apoptosis and development-related events (myoblast fusion, angiogenesis). While some terms are broader or cross-kingdom (e.g., ABA signaling), the dominant theme centers on neural development and signaling regulation, suggesting these proteins collectively participate in neural connectivity and developmental signaling rather than a single narrow function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007520","count":4},{"id":"GO:0009738","count":4},{"id":"GO:0034351","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0090153","count":4}]},{"hash":"2132453329387661835","title":"Embryonic Development and Organogenesis","description":"The top GO terms cluster around developmental processes across multiple tissues and stages, including trophoblast/placental differentiation, cartilage morphogenesis, endocrine system and pancreatic development, left/right patterning, and epithelial-to-mesenchymal transition in heart development, plus in utero embryonic development. This suggests a general theme of embryogenesis and organ formation, with a minor note that one term touches neuronal synaptic potentiation, which may reflect neural development rather than a core feature of the cluster. The lack of interactions (Edges 0) indicates the label is based on shared functional themes rather than a single molecular pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060972","count":2}]},{"hash":"185861585638395580","title":"Glycosylation and glycoprotein biosynthesis","description":"The cluster is enriched for glycan biosynthesis and post-translational O-glycosylation terms (arabinogalactan protein metabolism, Lewis a epitope biosynthesis, poly-N-acetyllactosamine biosynthesis, and hydroxyproline O-linked glycosylation). This points to a cohesive theme of glycoprotein modification and glycan assembly, common to extracellular matrices and cell surfaces, with related development and adhesion terms likely reflecting downstream roles in cell\u2013surface interactions. Therefore, a concise label emphasizing glycosylation processes best captures the shared function of these proteins.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001744","count":5},{"id":"GO:0075015","count":5},{"id":"GO:0042248","count":5},{"id":"GO:0007299","count":5},{"id":"GO:0080147","count":4}]},{"hash":"1493891848894069761","title":"Developmental signaling and vesicle trafficking proteins","description":"These proteins are linked to multiple developmental processes (nervous system, kidney, liver development) and key signaling pathways (Smoothened, Roundabout). They also relate to intracellular trafficking (endosome to melanosome transport) and proteostasis (ubiquitin-dependent ERAD), suggesting a theme of development-associated signaling and trafficking rather than a single precise function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0006508","count":4},{"id":"GO:0042832","count":3},{"id":"GO:0035646","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1023692521318941379","title":"Embryonic organogenesis and tissue differentiation","description":"The top GO terms cluster around differentiation and morphogenesis across multiple developing tissues (placenta, cartilage, endocrine organs, heart, pancreas, bone), suggesting a theme of embryonic organ formation and tissue specification. A few terms related to immune response and cardiac electrophysiology are present but less central.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060972","count":5}]},{"hash":"1656953635228336920","title":"Embryonic Development and Morphogenesis","description":"Based on GO terms dominated by developmental processes such as endocrine system development, EMT in heart cushion formation, left/right patterning, placental and pancreatic cell development, and cartilage morphogenesis. These together point to embryogenesis and tissue/t organ morphogenesis as the core theme of the cluster; the additional general processes may support gene expression during development but do not override the developmental focus.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0035270","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0060972","count":14},{"id":"GO:0060707","count":14},{"id":"GO:0060806","count":14}]},{"hash":"1345075860580708149","title":"Embryonic and Organ Morphogenesis","description":"The prominent GO terms relate to development across multiple organs (midbrain, pituitary, pancreas) and in utero embryonic development, indicating a shared theme of embryogenesis and organ formation. Transcriptional regulation by RNA Pol II (positive/negative) also aligns with developmental control. A single term about lipopolysaccharide response is somewhat discordant but does not negate the overall developmental theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032496","count":10},{"id":"GO:0030901","count":9},{"id":"GO:0000122","count":8},{"id":"GO:0045944","count":7},{"id":"GO:0001701","count":7}]},{"hash":"1126726096053710318","title":"Vertebrate embryogenesis and organogenesis","description":"These proteins show enrichment for GO terms tied to embryonic development across multiple tissues (neural crest migration, cranial skeleton morphogenesis, inner ear development, cartilage development, ureteric bud branching, trophoblast giant cell differentiation, embryonic organs). Although a couple of terms relate to transcriptional regulation and complement activation, the dominant pattern points to vertebrate embryogenesis and tissue morphogenesis as a unifying theme. The lack of edges suggests the label is derived from GO-term patterns rather than network structure.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0060707","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0001755","count":5},{"id":"GO:0090190","count":5}]},{"hash":"1748320122987733224","title":"Embryonic development and differentiation pathways","description":"The top GO terms are dominated by embryonic development, placental/trophoblast differentiation, tissue morphogenesis, and left-right patterning, indicating a cohesive cluster of proteins involved in developmental differentiation rather than general housekeeping processes. Some terms about RNA processing appear, but the prevailing signal centers on embryonic development and morphogenesis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060707","count":27},{"id":"GO:0060806","count":27},{"id":"GO:0060536","count":27},{"id":"GO:0035270","count":27},{"id":"GO:0060972","count":27}]},{"hash":"882822931936085907","title":"Heart development and conduction system","description":"The top terms point to cardiac morphogenesis (e.g., right atrium formation), Notch signaling in heart field regulation, and SA node action potential control, indicating a focus on heart development and electrical conduction. Supporting terms on venous differentiation and cytoskeletal remodeling further align with cardiac morphogenesis, while ubiquitination and vitamin D response may reflect broader developmental context. Overall, the cluster appears to center on heart formation and its electrophysiology, with some peripheral processes.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0097284","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0033280","count":4},{"id":"GO:0003270","count":4}]},{"hash":"1973284913715895135","title":"ER Stress and Secretory Pathway Regulation","description":"The top GO terms center on endoplasmic reticulum functions, including ER to Golgi vesicle transport and ER calcium homeostasis, plus several items about negative regulation related to unfolded protein response and apoptotic signaling. This points to a group of proteins involved in ER homeostasis and secretory pathway control, with a few neural-development terms that may reflect context rather than core function. Therefore, labeling as ER Stress and Secretory Pathway Regulation captures the main theme across the cluster.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0051025","count":1},{"id":"GO:0032469","count":1},{"id":"GO:0021702","count":1},{"id":"GO:1904721","count":1}]},{"hash":"1422763052705608641","title":"Immune Signaling and Angiogenesis Regulators","description":"This cluster includes GO terms for adaptive immune processes (defense against virus, T-helper 1 lineage commitment, IL-4 signaling, B cell differentiation) and for angiogenesis and endothelial migration, with ERK cascade regulation. The combination suggests proteins involved in coordinating immune signaling with vascular development/remodeling, such as inflammation-driven angiogenesis, hence the label.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0070374","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0043536","count":4},{"id":"GO:0007417","count":4}]},{"hash":"1744409336639326259","title":"Triglyceride and Lipoprotein Metabolism","description":"The top terms cluster around triglyceride catabolic and biosynthetic processes, triglyceride homeostasis, and remodeling/regulation of lipoprotein particles (LDL/VLDL), indicating a cohesive module in triglyceride turnover and lipoprotein metabolism. A few terms touch on detox/oxidation aspects, but the dominant signal is triglyceride metabolism and lipoprotein homeostasis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":15},{"id":"GO:0098869","count":10},{"id":"GO:0034374","count":10},{"id":"GO:0055114","count":9},{"id":"GO:0070328","count":9}]},{"hash":"813043880199481505","title":"Vascular and cartilage morphogenesis","description":"This cluster centers on developmental tissue formation, especially morphogenesis and vascular formation: coronary artery morphogenesis, endothelial cell chemotaxis, smooth muscle migration, and cell\u2013matrix adhesion, plus cartilage condensation. A few terms relate to signaling or immunity, but the dominant pattern is developmental morphogenesis and angiogenesis.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0048846","count":3},{"id":"GO:0048010","count":3},{"id":"GO:0050859","count":3}]},{"hash":"1251501929300451565","title":"ECM-Mediated Skeletal-Muscle Development","description":"The cluster shows strong signals for integrin-mediated signaling, ECM remodeling (hyaluronan metabolism, metallopeptidase activity), and myoblast fusion, which together underpin skeletal development and muscle formation. Embryonic cranial skeleton morphogenesis reinforces this theme, while DNA replication suggests proliferative growth; a minority of immune/dsRNA terms appear incidental.","confidence":"Medium","size":27,"edges":43,"triangles":16,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007229","count":8},{"id":"GO:1905050","count":8},{"id":"GO:0006260","count":8},{"id":"GO:0030212","count":8},{"id":"GO:0048701","count":7}]},{"hash":"551976599874116669","title":"Antiviral Innate Immune Signaling","description":"This cluster is enriched for innate immune functions and antiviral responses: innate immune response, response to interferon-alpha, and negative regulation of viral genome replication. It also includes T cell receptor signaling, suggesting adaptive immune involvement, and translational/translation initiation regulation by eIF2\u03b1 phosphorylation, reflecting host gene-expression control during antiviral defense. The presence of mRNA processing hints at broader RNA-processing roles linked to immune signaling. Overall, the dominant theme is antiviral/immune signaling, with some auxiliary RNA-processing and translation-control connections. ","confidence":"Medium","size":27,"edges":8,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045071","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0006397","count":6},{"id":"GO:0048013","count":5},{"id":"GO:0009636","count":5}]},{"hash":"830152680970412731","title":"Neuronal adhesion and synapse formation","description":"The cluster\u2019s terms cluster around neural development: cell-cell adhesion (homophilic/heterophilic), synapse assembly, and specific axonal localization, plus chemorepulsion guiding interneuron migration. These point to neuronal connectivity and guidance processes, with some peripheral terms like skeletal development or Notch regulation not altering the main theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0033138","count":4},{"id":"GO:0045746","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0007156","count":4}]},{"hash":"127566028164638288","title":"Neuronal adhesion and axon development","description":"The cluster is enriched for neural-related functions, notably homophilic cell-cell adhesion, neuron projection development, and localization to paranodes in axons, indicating proteins involved in neuronal connectivity and axon organization. While some terms (e.g., mesenchyme development) are less specific, the core theme centers on neuronal adhesion and axon guidance.","confidence":"High","size":27,"edges":325,"triangles":2335,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0060484","count":3},{"id":"GO:1903465","count":3},{"id":"GO:0002175","count":3}]},{"hash":"1423702788683307326","title":"Ubiquitin-Dependent ERAD and Proteostasis","description":"The top GO terms cluster around ubiquitin-mediated protein quality control, especially ER-associated degradation (ERAD) and regulation of deubiquitination, implying these proteins participate in ubiquitin-regulated proteostasis and elimination of misfolded proteins in the ER, with additional links to autophagy and vesicle trafficking.","confidence":"High","size":27,"edges":36,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":8},{"id":"GO:2000157","count":5},{"id":"GO:1903094","count":5},{"id":"GO:1904378","count":5},{"id":"GO:0071732","count":4}]},{"hash":"852414396375036941","title":"Thermosensory and Retina Signaling","description":"This cluster centers on temperature-related senses (thermogenesis, temperature stimulus, pain perception) and phototransduction/retina development, with accompanying calcium signaling and membrane potential regulation. Together these terms point to a shared theme of sensory/light signaling and neuronal/excitable-cell calcium dynamics, despite some peripheral immune-related terms present. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0042493","count":14},{"id":"GO:0042742","count":13}]},{"hash":"45198593642790128","title":"Neural signaling and thermosensory behavior","description":"The top GO terms cluster around nervous system functions: sensory perception of pain, locomotory and visual learning behaviors, and GPCR/GTPase signaling pathways, with a subset tied to cellular responses to temperature. This points to neural communication and temperature-related behavioral responses as the core theme, with energy metabolism (electron transport chain) likely supporting these processes. Confidence that this label captures the cluster\u2019s function is Moderate, given the mix of neural/behavioral terms with broader metabolic terms.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0008542","count":10},{"id":"GO:0007626","count":9}]},{"hash":"2301839543020552647","title":"Multi-tissue development and signaling","description":"The top GO terms point to organ-specific development (enteric nervous system, kidney glomerulus, nipple morphogenesis, lung connective tissue, oligodendrocyte differentiation) combined with broad signaling activities (calcium release, GTPase regulation) and processes like inflammation, vascular permeability, and mucus secretion. This suggests a cluster of proteins involved in developmental programs across multiple tissues and their signaling dynamics, rather than a single tissue- or pathway-specific function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048484","count":4},{"id":"GO:0051209","count":4},{"id":"GO:0043114","count":3},{"id":"GO:0072224","count":3},{"id":"GO:0070257","count":3}]},{"hash":"506796416222303075","title":"Calcium-Driven Synaptic Transmission and Plasticity","description":"Based on the top terms, the cluster is dominated by neuronal signaling processes: calcium-ion\u2013mediated responses, regulation of synaptic vesicle exocytosis, neurotransmitter secretion, and long-term potentiation, all pointing to calcium-dependent synaptic transmission and plasticity. Other terms (PI signaling, VEGF receptor signaling) may complement these pathways, while mitotic cell cycle and ABA signaling appear less central to the core theme. Overall, the terms coalesce around calcium-controlled synaptic activity and plastic changes.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:2000300","count":5},{"id":"GO:0071277","count":5},{"id":"GO:0009738","count":5},{"id":"GO:0048015","count":5}]},{"hash":"1783533889267760946","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":12},{"id":"GO:0000398","count":12},{"id":"GO:0071031","count":12},{"id":"GO:0015074","count":12},{"id":"GO:0039702","count":12}]},{"hash":"1076717645158275406","title":"Notch-ERK Developmental Signaling","description":"This cluster appears tied to developmental signaling and differentiation, highlighted by Notch signaling and positive regulation of ERK1/ERK2 cascade. The mix of terms covering somitogenesis, spinal cord neuron specification, lateral line nerve development, megakaryocyte development, and macrophage foam cell differentiation suggests a broad role for signaling pathways in lineage choice and tissue development, with protein ubiquitination and rDNA heterochromatin formation indicating coordinated transcriptional and epigenetic regulation during these processes.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010742","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0070374","count":3},{"id":"GO:0007219","count":3},{"id":"GO:1902083","count":3}]},{"hash":"554314993736960164","title":"Developmental Transcription Regulators","description":"Most terms center on DNA-templated transcription and regulation of transcription-related activity, with several entries indicating developmental processes in brain regions (cerebellar cortex and hippocampus) and heart development. There are also terms related to nuclear processes (DNA replication initiation, protein export from nucleus) and signaling regulation, suggesting a set of proteins that regulate gene expression during development and tissue-specific signaling.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006469","count":2},{"id":"GO:0021695","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0021766","count":2}]},{"hash":"653486609277223257","title":"Synaptic plasticity and spine morphogenesis","description":"The top GO terms cluster around neuronal synapses and spine biology: long-term synaptic depression, regulation of excitatory postsynaptic potential, dendritic spine morphogenesis, and actin cytoskeleton organization, indicating changes in synaptic strength and structure. Behavioral terms like social and grooming behavior, plus localization patterns related to neural tissue, support a neural circuit function theme. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051660","count":5},{"id":"GO:0060292","count":5},{"id":"GO:0046328","count":4},{"id":"GO:0060997","count":4},{"id":"GO:0035176","count":4}]},{"hash":"260261722901997674","title":"Neural and cardiac signaling regulators","description":"The top GO terms point to neural signaling (excitatory postsynaptic potential, visual perception) and cardiac-related processes (heart rate regulation, heart development), with calcium transport and calcineurin-NFAT signaling bridging these domains. The mix suggests proteins that modulate signaling in both nervous system and heart, potentially via calcium-dependent pathways, rather than a single specialized process. Confidence: Medium","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:2001046","count":3},{"id":"GO:2000637","count":2},{"id":"GO:2000678","count":2},{"id":"GO:0007601","count":2}]},{"hash":"731170752627322879","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0019076","count":4},{"id":"GO:0071031","count":4},{"id":"GO:0015074","count":4}]},{"hash":"606216123651535254","title":"Monoamine Neurotransmission and Behavioral Regulation","description":"The most represented terms cluster around monoamine metabolism and signaling (dopamine catabolic process; octopamine biosynthetic and signaling pathways) along with behavioral phenotypes (memory; responses to amphetamine and ethanol), suggesting a theme of neuromodulation driving behavior. A few other terms (maternal behavior, wing development, leukocyte migration) seem less central to this core theme but are present in the set. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":5},{"id":"GO:0007613","count":5},{"id":"GO:0050900","count":4},{"id":"GO:0048149","count":4},{"id":"GO:0042420","count":4}]},{"hash":"1729399500477181689","title":"Vesicle trafficking and exocytosis","description":"The top GO terms point to intracellular transport along the secretory and endosomal pathways, including Golgi-to-plasma membrane transport, endosome-to-melanosome transport, and regulation of synaptic vesicle exocytosis, suggesting the cluster is enriched for vesicle trafficking and exocytosis\u2013related proteins. Additional terms related to brain development and stress responses may reflect context-specific roles or regulatory connections, but the dominant theme is vesicular transport and exocytosis regulation across cellular compartments.","confidence":"Medium","size":27,"edges":113,"triangles":100,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043001","count":7},{"id":"GO:0090324","count":7},{"id":"GO:0010796","count":5},{"id":"GO:2000300","count":5},{"id":"GO:0031384","count":5}]},{"hash":"1004354237755988193","title":"Neurodevelopment: axon guidance and adhesion","description":"The top terms cluster around nerve maturation, axon guidance (e.g., branchiomotor neuron axon guidance), axonal fasciculation, nerve structural organization (trigeminal nerve), and cell adhesion (homophilic cell-cell adhesion, general cell adhesion), together pointing to proteins involved in neural development and connectivity. A single outlier term (complement activation) is less related, but the overall pattern strongly supports a neural development and adhesion theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0021682","count":4},{"id":"GO:0060445","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0021785","count":4}]},{"hash":"1036352260404610354","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000480","count":5},{"id":"GO:0000447","count":5},{"id":"GO:0000472","count":5},{"id":"GO:0000398","count":4},{"id":"GO:0050830","count":4}]},{"hash":"1328149254784390230","title":"Immune receptor signaling and ubiquitin regulation","description":"The cluster is dominated by GO terms for innate and adaptive immune receptor signaling (stimulatory C-type lectin receptor, Fc-epsilon receptor, and T cell receptor pathways). Co-occurring ubiquitin-related processes (deubiquitination and proteasomal pathways) suggest regulation of signaling via the ubiquitin-proteasome system, making this a coherent theme around immune signaling with ubiquitin-mediated control.","confidence":"High","size":27,"edges":163,"triangles":723,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":16},{"id":"GO:0016579","count":13},{"id":"GO:0038095","count":10},{"id":"GO:0050852","count":10},{"id":"GO:0090263","count":10}]},{"hash":"910356785265353426","title":"Mitosis and APC/C-mediated ubiquitination","description":"The terms cluster around mitosis and ubiquitin-mediated regulation: cell division, mitotic cell cycle, and anaphase-promoting complex-dependent catabolic process, plus K11-linked ubiquitination and sister chromatid cohesion, pointing to APC/C-driven mitotic progression. TORC1 signaling and histone H3-K79 methylation hint at chromatin/growth coordination in the cycle; the metal ion response terms are likely secondary.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0031145","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1177491135837544694","title":"DNA replication and mitotic control with stress signaling","description":"This cluster centers on core cell cycle processes (DNA replication, spindle-kinetochore attachment, intra-S DNA damage checkpoint) and includes signaling and stress-response terms (apoptotic regulation, NFAT signaling, cardiac hypertrophy, angiogenesis). The combination suggests proteins involved in coordinating cell cycle progression with cellular stress responses and related signaling pathways.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:2001241","count":4},{"id":"GO:0070262","count":4},{"id":"GO:1903799","count":4},{"id":"GO:0051531","count":3}]},{"hash":"929176609699877449","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006295","count":1},{"id":"GO:1901536","count":1},{"id":"GO:1901224","count":1},{"id":"GO:0034198","count":1},{"id":"GO:1902187","count":1}]},{"hash":"269644675099346085","title":"Developmental signaling and morphogenesis","description":"This cluster prominently features GO terms related to developmental processes (nervous system development, limb bud formation, salivary gland morphogenesis, general multicellular organism development) and signaling pathways (BMP, ERK/MAPK), suggesting proteins that coordinate tissue growth and structure formation. A secondary immune-related term (complement activation) is less central to the core theme, making a developmental signaling/morphogenesis role the most representative overall.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0060445","count":4},{"id":"GO:0060484","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0007275","count":4}]},{"hash":"2088267548746534962","title":"ECM Remodeling and Endosomal Trafficking","description":"The GO terms cluster around extracellular matrix-related processes (basement membrane organization, amelogenesis, embryo implantation) and membrane trafficking activities (receptor recycling, endosome size), suggesting a functional theme where ECM remodeling is linked to vesicle trafficking. Some outliers (peptidoglycan catabolic process, obsolete terms) may reflect annotation noise, but the core signal supports ECM organization with trafficking.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071711","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0007566","count":2},{"id":"GO:0097186","count":2},{"id":"GO:0006355","count":1}]},{"hash":"1374513658557251515","title":"GPCR Signaling and Immune Regulation","description":"The cluster\u2019s top GO terms center on G protein-coupled receptor (GPCR) signaling and its regulation, plus immune and inflammatory processes (immune response, response to lipopolysaccharide, prostaglandin response, regulation of inflammatory response). This suggests proteins that participate in GPCR-mediated signal transduction with roles in immune modulation, making the GPCR-immune axis a cohesive functional theme for the cluster.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035625","count":3},{"id":"GO:0050728","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0001991","count":2},{"id":"GO:0007195","count":2}]},{"hash":"1452167368258224958","title":"Sensory Detection and Synaptic Regulation","description":"The top terms cluster around sensory perception (pain detection via temperature and mechanical stimuli; sour taste; salt aversion) together with homeostatic and signaling regulation (sodium ion homeostasis, pH response, and regulation of synaptic activity/ neurotransmitter secretion). Despite no reported interactions, these terms point to a coherent theme of sensory signaling and modulation of neurotransmission.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090116","count":2},{"id":"GO:0050965","count":1},{"id":"GO:0071467","count":1},{"id":"GO:0035179","count":1},{"id":"GO:0035199","count":1}]},{"hash":"1865618988776256327","title":"Developmental and Cytoskeletal Signaling","description":"Many terms point to development and tissue formation (multicellular development, skin development). Several terms reflect signaling and cytoskeletal dynamics (Arp2/3 actin nucleation, phosphorylation, GTPase activity). A few terms indicate broader cellular processes like mitotic cell cycle and mRNA transport, plus stress/immune responses (hypoxia, defense to Gram-positive bacteria). This suggests a cluster centered on developmental signaling with cytoskeletal regulation, rather than a single focused function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0071456","count":5},{"id":"GO:2000601","count":5}]},{"hash":"148205209198218189","title":"Glycogen, starch, and sugar metabolism","description":"Proteins in this cluster are dominated by GO terms for glycogen catabolic and biosynthetic processes, starch and alpha-glucan metabolism, and various sugar-related pathways (maltose, sucrose, oligosaccharides). This suggests a cohesive theme of carbohydrate metabolism and glycan biosynthesis rather than a single enzymatic function, even though there are no interaction edges to tie specific proteins. Overall, the cluster centers on carbohydrate metabolism and glycan synthesis activities.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005980","count":4},{"id":"GO:0010493","count":4},{"id":"GO:0005978","count":3},{"id":"GO:0044245","count":3},{"id":"GO:0005983","count":3}]},{"hash":"402229010403610721","title":"Cilium-Associated Trafficking and Visual Perception","description":"Top terms indicate strong links to cilium biology (cilium assembly), vesicle trafficking (receptor recycling, endosome size), and sensory functions (visual perception, sensory neuron guidance, pheromone response). The presence of mitotic cell cycle and GTPase regulation terms suggests overlap with cell-cycle control, a known feature of many ciliary proteins. This points to proteins involved in cilium-dependent trafficking and photoreceptive signaling.","confidence":"High","size":26,"edges":309,"triangles":2244,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":13},{"id":"GO:0000278","count":13},{"id":"GO:0043547","count":11},{"id":"GO:0001881","count":10},{"id":"GO:0060271","count":10}]},{"hash":"2246206866826176232","title":"Neuronal signaling and sensory processing","description":"The cluster centers on neural signaling and sensory functions, with prominent terms for dopaminergic synaptic transmission, visual perception/learning, cocaine response, prostaglandin signaling, and ERK cascade regulation, all pointing to neuronal activity and sensory processing. While a couple of terms (macrophage chemotaxis, heart development) are less aligned, the dominant theme is neuronal signaling and sensory perception.","confidence":"High","size":26,"edges":92,"triangles":45,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0048148","count":19},{"id":"GO:0007601","count":19},{"id":"GO:0007507","count":19}]},{"hash":"580317177259319021","title":"Renal nephron and duct morphogenesis","description":"The top GO terms are dominated by metanephric nephron/ tubule and mesonephric duct development, indicating a cohesive role in kidney morphogenesis and nephrogenesis (proximal/distal tubules, ascending limb, duct formation). While there are a few vascular/immune-related terms present, they appear secondary to the strong kidney development signal, suggesting the cluster centers on renal organogenesis with possible related tissue remodeling. ","confidence":"High","size":26,"edges":86,"triangles":288,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0036303","count":14},{"id":"GO:0072287","count":14},{"id":"GO:0010572","count":14},{"id":"GO:0072218","count":14},{"id":"GO:0090403","count":14}]},{"hash":"11570106924350912","title":"DNA Repair and Genome Maintenance","description":"This cluster centers on base-excision repair, DNA recombination, and apoptotic processes, suggesting a theme of genome integrity maintenance and cell fate decisions; it also includes a nuclear migration term, hinting at broader chromosomal dynamics. A few plant-specific terms appear (abscisic acid homeostasis, chloroplast movement) that are not core to this core DNA-damage response signal.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":5},{"id":"GO:0007568","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0031022","count":3}]},{"hash":"1352616853788807691","title":"GPCR signaling in vascular, neural, and immune regulation","description":"The top GO terms are dominated by GPCR-related signaling and its regulatory roles in cardiovascular function (e.g., regulation of blood pressure via renin-angiotensin, dopamine receptor signaling, acetylcholine metabolism, prostaglandin response, and GPCR pathway modulation). Immune processes (immune response, IL-1\u03b2 production) and vascular smooth muscle differentiation also appear, suggesting a coherent theme around GPCR-mediated signaling coordinating vascular, neural, and immune functions, with a few terms related to development or cytolysis likely reflecting broader regulatory roles or annotation noise.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":21},{"id":"GO:0007195","count":21},{"id":"GO:0060408","count":21},{"id":"GO:0007497","count":21},{"id":"GO:0006955","count":21}]},{"hash":"1226176528862151305","title":"GPCR-Mediated Immune and Vascular Regulation","description":"The cluster is dominated by GPCR signaling terms (positive regulation of GPCR signaling; dopamine and acetylcholine signaling; prostaglandin response) and cardiovascular-related processes (renin-angiotensin\u2013linked blood pressure regulation, vascular smooth muscle differentiation), with supporting immune-associated terms (immune response, IL-1\u03b2 production, cytolysis). This points to a coherent theme where GPCR pathways coordinate immune responses with vascular and cardiovascular functions, despite one outlier developmental term. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":21},{"id":"GO:0007195","count":21},{"id":"GO:0060408","count":21},{"id":"GO:0007497","count":21},{"id":"GO:0006955","count":21}]},{"hash":"1697055238330328625","title":"Arabinogalactan Protein Glycosylation and AGP Biosynthesis","description":"The top GO terms point strongly to arabinogalactan proteins (AGPs) and their glycosylation pathways, including arabinogalactan protein metabolic process, poly-N-acetyllactosamine biosynthesis, Lewis a epitope biosynthesis, and plant mucilage/seed coat glycan production, with related plant development processes like root hair formation. This indicates a cohesive theme of plant cell surface glycoprotein biosynthesis and modification centered on AGPs, despite a few outlier terms.","confidence":"High","size":26,"edges":32,"triangles":5,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":13},{"id":"GO:0001744","count":8},{"id":"GO:0042248","count":8},{"id":"GO:0007299","count":8},{"id":"GO:0030311","count":8}]},{"hash":"483265948472198863","title":"Neuronal mitochondrial dynamics with GPCR trafficking","description":"The top terms converge on mitochondrial organization and fission, intracellular distribution, and membrane dynamics, with supporting mentions of GPCR internalization, morphine response, and brain development, suggesting a neuronal module coordinating mitochondrial behavior with GPCR trafficking. ","confidence":"High","size":26,"edges":38,"triangles":0,"max_degree":12,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0048312","count":5},{"id":"GO:0007006","count":4},{"id":"GO:0000266","count":4},{"id":"GO:0007049","count":4}]},{"hash":"1320095904722637825","title":"Chlorophyll and Quinone Biosynthesis","description":"The GO terms show strong enrichment for chlorophyll biosynthesis and several quinone biosynthesis processes (plastoquinone, phylloquinone, menaquinone, vitamin K), plus heme O biosynthesis, indicating a cohesive focus on pigment and redox-cofactor production. While there are some fatty-acid beta-oxidation terms present, the dominant signal is pigment/cofactor biosynthesis, supporting this label.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0033540","count":3},{"id":"GO:0019254","count":3},{"id":"GO:0032194","count":2},{"id":"GO:0009234","count":2}]},{"hash":"2267847629376137467","title":"Unknown","description":"The top GO terms span bone formation and mineralization, neural signaling (synaptic vesicle clustering and neuromuscular processes), immune responses (interferon signaling and biotic stimuli), and general vesicle transport, reflecting disparate, multifunctional roles rather than a single cohesive function for the cluster; thus a concise, representative label cannot be derived.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030282","count":3},{"id":"GO:0097091","count":3},{"id":"GO:0060349","count":3},{"id":"GO:0099638","count":3},{"id":"GO:0044381","count":3}]},{"hash":"1161053644482048996","title":"Ribosome and Translation Machinery","description":"Most of the top GO terms are centered on translation and ribosome function: cytoplasmic translation (GO:0006412) with many associated terms (initiation, elongation, termination, ribosome disassembly) and even mitochondrial translation, indicating the cluster groups proteins involved in the protein synthesis machinery. While a few terms touch RNA decay or glial proliferation, the dominant theme is ribosome- and translation-related processes, justifying this label.","confidence":"High","size":26,"edges":313,"triangles":2338,"max_degree":25,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":23},{"id":"GO:0032790","count":7},{"id":"GO:2000767","count":7},{"id":"GO:0002184","count":7},{"id":"GO:0070125","count":7}]},{"hash":"433334826732938747","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":16,"triangles":20,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042273","count":8},{"id":"GO:0000463","count":8},{"id":"GO:0000466","count":8},{"id":"GO:0000462","count":8},{"id":"GO:0000398","count":7}]},{"hash":"297023476412114714","title":"Gene expression and RNA processing during development","description":"This cluster is dominated by RNA metabolism and protein synthesis terms (splicing, rRNA maturation, translation initiation/reinitiation, transcription) with a developmental context (multicellular development, cardiac muscle apoptotic process), suggesting a cohesive role in gene expression control during development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001731","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0006349","count":5}]},{"hash":"1917901046936260335","title":"Rho/Rac signaling and cytoskeletal remodeling","description":"The dominant GO terms center on regulation of Rho and Rac signaling, lamellipodium assembly, cell migration, and adhesion-dependent spreading, indicating a cohesive theme of actin cytoskeleton remodeling driving cell movement. While insulin signaling and heart development appear among the terms, the core cluster is best described by cytoskeletal dynamics and migratory behavior.","confidence":"High","size":26,"edges":32,"triangles":2,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":17},{"id":"GO:0008286","count":16},{"id":"GO:0097113","count":15},{"id":"GO:0016477","count":15},{"id":"GO:0030032","count":15}]},{"hash":"1187320862856855401","title":"NOD1/2 Signaling and Necroptosis Regulation","description":"GO terms indicate enrichment for NOD1/2 signaling pathways, TLR signaling regulation, and necroptosis, with involvement of poly- and monoubiquitination, suggesting a module focused on innate immune sensing and ubiquitin-mediated cell death control. Some terms related to axon extension and cell cycle appear peripherally, but the core theme is innate immune signaling and programmed necroptosis regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0070427","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0030516","count":3}]},{"hash":"1980184692590716276","title":"Neural development and morphogenesis","description":"This cluster is dominated by GO terms related to neural development (brain development, neural crest cell migration) and embryonic morphogenesis, with supporting involvement of Wnt signaling and calcium modulation during development. The terms point to developmental processes shaping neural tissues and overall embryonic structure, rather than metabolic or immune functions.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001755","count":2},{"id":"GO:2001015","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0007223","count":2}]},{"hash":"515555826756190897","title":"Developmental actin remodeling and GTPase signaling","description":"The top GO terms point to actin cytoskeleton organization (actin crosslink formation, microspike assembly) and regulation of GTPase activity, along with developmental processes like bone and heart development. This suggests a cluster of proteins involved in actin-based remodeling and signaling during development and tissue morphogenesis. While some immune signaling terms appear, the cohesive theme is cytoskeletal dynamics coupled with developmental regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060348","count":6},{"id":"GO:0051764","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0070493","count":4}]},{"hash":"1057714252495983728","title":"Dopaminergic and Glycinergic Brain Signaling","description":"This cluster shows a pattern of brain development terms (striatum and thalamus development, adenohypophysis development) together with neurotransmission-related terms (dopamine uptake, dopamine catabolic process, glycinergic synaptic transmission), suggesting a neural signaling theme in brain development. A few terms pertain to cell cycle or ubiquitination, but the dominant signal aligns with dopamine- and glycine-mediated neural communication.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0021756","count":7},{"id":"GO:0021794","count":6},{"id":"GO:0042420","count":6},{"id":"GO:0070979","count":6},{"id":"GO:0007091","count":6}]},{"hash":"915730035493991972","title":"Unknown","description":"Top GO terms span development, regulation, signaling, cell division, and metabolism with no clear common function. With no edges connecting proteins, there is no cohesive pathway linking them, so a single, interpretable label cannot be assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0006469","count":2},{"id":"GO:0045944","count":2},{"id":"GO:1902527","count":2},{"id":"GO:0032465","count":2}]},{"hash":"1970716638278371769","title":"RNA modification and mRNA processing","description":"The top terms cluster around RNA modification: tRNA methylation, wobble uridine modification, mRNA capping, and related protein modification, suggesting a set of RNA-modifying enzymes and RNA-processing factors. Some terms like interleukin-1 response or cocaine response likely reflect broader signaling roles or annotation noise, but the dominant theme is RNA modification.","confidence":"Medium","size":26,"edges":219,"triangles":854,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0070555","count":4},{"id":"GO:0018027","count":4},{"id":"GO:0010189","count":4},{"id":"GO:1901052","count":4},{"id":"GO:0030488","count":4}]},{"hash":"1247159329218456056","title":"Neural development and sensory organ morphogenesis","description":"This cluster centers on neural formation and sensory organ development, as shown by terms like axonal fasciculation, convergent extension in neural plate elongation, cochlea morphogenesis, and vocalization/social behavior. Adherens junction localization also points to developing neural tissue where cell-cell adhesion is key. Immune signaling terms appear tangentially, but the dominant theme is neural development and sensory organ morphogenesis.","confidence":"Medium","size":26,"edges":28,"triangles":0,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0071625","count":3},{"id":"GO:0090179","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0032088","count":3}]},{"hash":"1669990519620699697","title":"Developmental Signaling and Organogenesis","description":"This cluster centers on organ and nervous system development (kidney, heart, nervous system, dendrite regulation) and key signaling pathways (Smoothened/Hedgehog, Roundabout/ROBO). It also includes proliferation and immune signaling (T cell receptor). Together these terms suggest proteins involved in broad developmental signaling programs that coordinate organogenesis and neural maturation across tissues, rather than a single tissue-specific function.","confidence":"High","size":26,"edges":273,"triangles":1559,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":9},{"id":"GO:0007224","count":9},{"id":"GO:0035385","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0050852","count":9}]},{"hash":"732676739491951166","title":"Membrane Nutrient Transporters","description":"Proteins in this cluster are linked to transmembrane transport of diverse nutrients and ions, including biotin, pantothenate, glucose, myo-inositol, and amino acids, across plasma membranes and vacuolar membranes. The dominant GO terms point to transporter activity rather than a single biosynthetic function; one outlier term (acetylcholine biosynthetic process) is unlikely to reflect the core theme, but the overall pattern supports membrane nutrient transport roles.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008292","count":4},{"id":"GO:0015878","count":4},{"id":"GO:0071436","count":4},{"id":"GO:0015798","count":4},{"id":"GO:0015887","count":4}]},{"hash":"1277048827191131448","title":"Translation machinery and mitochondrial energy metabolism","description":"This cluster is dominated by translation-related GO terms (cytoplasmic translation, translation, ribosomal large subunit assembly), alongside mitochondrial ATP synthesis and electron transport, suggesting a core theme around protein synthesis coupled with mitochondrial energy production. Additional terms about prenylated protein processing and nuclear envelope organization indicate peripheral related processes, but the central signal centers on translation machinery and mitochondrial metabolism.","confidence":"Medium","size":26,"edges":163,"triangles":346,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0051412","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0042775","count":2}]},{"hash":"375480174007853933","title":"ER\u2013Golgi Vesicle Trafficking and Golgi Inheritance","description":"The top GO terms point to transport between the ER and Golgi, including retrograde transport, plus Golgi inheritance and Golgi-to-vacuole routing, indicating a core function in the secretory pathway and Golgi dynamics during cell division. Neuronal process terms may reflect broader vesicle trafficking roles, but the central theme is ER\u2013Golgi trafficking and Golgi remodeling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0048313","count":2}]},{"hash":"1698297255819899585","title":"Complement-Platelet Activation Network","description":"The top GO terms cluster around immune-related processes: activation of complement pathways (lectin and alternative), regulation of complement activation, membrane attack complex activation, platelet activation, and leukocyte tethering/rolling, which together point to innate immune defense involving complement and platelets. Some neural development terms appear but are likely incidental; the central theme appears to be complement-mediated immune activation and platelet interactions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":2},{"id":"GO:0050901","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0021680","count":1},{"id":"GO:2001241","count":1}]},{"hash":"522813513889613958","title":"Cartilage and bone morphogenesis","description":"This cluster is dominated by terms tied to skeletal development and extracellular matrix (ECM) remodeling, including cartilage formation (growth plate cartilage development), collagen catabolic processes, and embryonic cranial skeleton morphogenesis. The inclusion of ECM disassembly and proteolysis supports a theme of matrix remodeling essential for skeletal formation. Some terms like amelogenesis and midbrain development appear as peripheral signals but don\u2019t override the dominant skeletogenic pattern.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0022617","count":4},{"id":"GO:0030574","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0003417","count":4}]},{"hash":"602565408277197624","title":"Ubiquitin-Dependent Protein Degradation (ERAD)","description":"The strongest signal in this cluster is ubiquitin-dependent protein catabolic process (GO:0042787) with 15 proteins and ubiquitin-dependent ERAD pathway (GO:0030433) with 8, indicating a proteostasis/ubiquitin-proteasome degradation theme. While other terms cover diverse areas (circadian regulation, development, etc.), the dominant ubiquitin-mediated degradation annotations best explain the cluster\u2019s shared function. The lack of network edges suggests these proteins cluster by annotation rather than direct interactions, but the proteostasis pattern remains clear.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0030433","count":8},{"id":"GO:0051260","count":8},{"id":"GO:0033280","count":7},{"id":"GO:0042752","count":7}]},{"hash":"2275007414347740622","title":"Glial BBB establishment and neural signaling","description":"The top GO terms point to CNS-related barrier functions (establishment of glial blood-brain barrier) and neural communication (synaptic transmission), with several adhesion and stress response terms suggesting cell-contacts and mechanosensitive contexts. While a few terms are peripheral or noisy (viral process, prostate development), the strongest coherent theme centers on glial barrier maintenance and neural signaling aspects, implying a cluster enriched for CNS barrier and neuronal interaction functions.","confidence":"Medium","size":26,"edges":24,"triangles":0,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0060857","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0007161","count":2}]},{"hash":"596643281054857902","title":"Renal/Metanephric Morphogenesis","description":"Based on the prominent GO terms related to metanephric tubule and duct development (distal/proximal tubules, mesonephric duct) and broader renal morphogenesis, the cluster appears to reflect kidney/urinary tract organogenesis. Some terms (e.g., cartilage condensation, leukocyte tethering) seem less connected and may be noise, but the renal development signal is strong and coherent.","confidence":"High","size":26,"edges":35,"triangles":3,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":19},{"id":"GO:0001502","count":17},{"id":"GO:0036303","count":16},{"id":"GO:0072287","count":16},{"id":"GO:0010572","count":16}]},{"hash":"1707294545273535134","title":"Cardiovascular development and endothelial differentiation","description":"The term set centers on heart formation (cardiac right atrium morphogenesis, Notch-regulated cardioblast proliferation) and vascular differentiation (venous endothelial cell differentiation), with related processes like cell migration and calcium signaling, consistent with a cluster of proteins involved in cardiogenesis and vascular development; vitamin D response and calcium import reflect calcium signaling links in these processes.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":8},{"id":"GO:0033280","count":8},{"id":"GO:0003270","count":8},{"id":"GO:0003213","count":8},{"id":"GO:0060843","count":8}]},{"hash":"778576190373100706","title":"Bacterial Metabolism: Biosynthesis and Catabolism","description":"These proteins map to a broad set of bacterial metabolic processes, including biosynthesis (antibiotics, PHB, menaquinone), redox/oxidant detoxification, and various catabolic pathways (uracil, triglycerides) plus nitrogen utilization and proteolysis. The diversity and lack of a single dominant pathway or edges indicate a general metabolic cluster rather than a specific function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0017000","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0009234","count":3}]},{"hash":"1150166936607965176","title":"Neural Development with Innate Immune Signaling","description":"The top GO terms cluster around axonal fasciculation, synapse assembly, and myelination, which point to neural development and neural membrane trafficking. The presence of innate immune components (innate immune response, TLR7/9 signaling) indicates an accompanying immune signaling role within this cluster. A few terms like bone development and follicle-stimulating hormone response appear less central, but do not override the neural-immune theme.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0006612","count":3},{"id":"GO:0048681","count":2},{"id":"GO:0045087","count":2}]},{"hash":"637743628739025368","title":"Cardiac development and electrophysiology","description":"The top GO terms cluster around heart formation and electrical activity, including morphogenesis of cardiac structures (outflow tract, left ventricle), regulation of atrial and SA node action potentials, Purkinje signaling, and calcium handling via the sarcoplasmic reticulum\u2014together reflecting cardiac development linked to excitation-contraction signaling.","confidence":"High","size":25,"edges":53,"triangles":18,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903244","count":10},{"id":"GO:0043931","count":10},{"id":"GO:0007275","count":10},{"id":"GO:0098910","count":8},{"id":"GO:0014808","count":8}]},{"hash":"830377079678143807","title":"Cell Growth and Protein Homeostasis","description":"The cluster centers on core cellular processes\u2014DNA replication, cell division, transcription, ribosome biogenesis, ER-Golgi transport, proteasomal degradation, and ER-stress\u2013induced apoptosis\u2014indicating a theme of growth and protein handling rather than a single pathway; some neural-development terms may be incidental.","confidence":"Medium","size":25,"edges":48,"triangles":45,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046677","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0042254","count":5}]},{"hash":"1158912048311188184","title":"Heterochromatin Formation & Chromatin Regulation","description":"The top GO terms point to heterochromatin formation and chromatin-based transcription control (silent mating-type silencing, rDNA heterochromatin, histone phosphorylation/methylation regulation, RNAP I transcription). A few terms touch on germline and epithelial differentiation, but the dominant signal is chromatin organization and transcriptional regulation.","confidence":"Medium","size":25,"edges":204,"triangles":778,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0030466","count":14},{"id":"GO:0007338","count":14},{"id":"GO:0002227","count":13},{"id":"GO:0033128","count":13},{"id":"GO:1901837","count":13}]},{"hash":"1151665459454290979","title":"Embryonic neural and cardiac organogenesis","description":"The terms cluster around embryonic organogenesis, especially heart development and cranial skeleton morphogenesis, with neural development and motor neuron guidance (neuron migration, medial motor column differentiation) and epithelial maturation. This suggests a coordinated developmental program governing neural and cardiac tissue formation during embryogenesis, under transcriptional regulation.","confidence":"High","size":25,"edges":68,"triangles":15,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001759","count":9},{"id":"GO:0000122","count":8},{"id":"GO:0048701","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0003350","count":8}]},{"hash":"1442826852119122835","title":"Unknown","description":"The GO terms span diverse processes\u2014from cell proliferation and development (retina and midgut) to various signaling pathways (dopamine/acetylcholine signaling, GTPase regulation, prostaglandin response) and immune involvement\u2014showing no cohesive, single functional theme for the cluster. ","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008283","count":14},{"id":"GO:0008284","count":14},{"id":"GO:0060041","count":14},{"id":"GO:0043547","count":14},{"id":"GO:0001991","count":13}]},{"hash":"2231540545993153461","title":"Immune development and developmental morphogenesis","description":"This cluster shows a strong mix of immune-related signaling (T cell receptor signaling, beta selection, mast cell degranulation) and developmental/morphogenetic processes (embryonic cranial skeleton morphogenesis, axon extension) along with cytoskeletal and adhesion regulation. The recurrent themes suggest proteins involved in signaling during immune development and cell movement/shape changes essential for morphogenesis, rather than a single, narrow pathway. ","confidence":"Medium","size":25,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":16},{"id":"GO:0006260","count":16},{"id":"GO:0051893","count":15},{"id":"GO:0043552","count":15},{"id":"GO:0043366","count":15}]},{"hash":"1319624676546916029","title":"Lipid Biosynthesis and Fatty Acid Metabolism","description":"The top terms cluster around lipid-related processes: lipoteichoic acid biosynthesis, fatty acid biosynthesis, long-chain fatty acid metabolism, and bile acid metabolism, pointing to a core theme of lipid metabolism. While some terms refer to plant-specific or broader metabolic pathways (seed germination regulation, phenylpropanoid metabolism), the dominant signal is lipid biosynthesis and utilization. ","confidence":"Medium","size":25,"edges":143,"triangles":345,"max_degree":21,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070395","count":10},{"id":"GO:0006633","count":9},{"id":"GO:0010030","count":9},{"id":"GO:0019654","count":9},{"id":"GO:0090410","count":9}]},{"hash":"988783504862370803","title":"Unknown","description":"The top GO terms come from very different biological contexts (insect eye development and follicular epithelium polarity/adhesion; plant cell wall biosynthesis and plasmodesmata organization; infection structure formation), with no clear, single process linking the proteins. There are no interaction signals (edges/triangles), so a unified functional theme is not evident.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":6},{"id":"GO:0006310","count":4},{"id":"GO:0001744","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0007299","count":4}]},{"hash":"1329770088230157091","title":"Plant arabinogalactan protein glycosylation and mucilage biosynthesis","description":"This cluster is dominated by GO terms tied to arabinogalactan protein (AGP) metabolism and O-linked glycosylation via hydroxyproline, plus mucilage biosynthesis in seed coats and related plant developmental processes (root hair development, cell adhesion). The recurring theme is plant extracellular matrix and cell wall glycoprotein biosynthesis/modification, with AGP glycosylation as a central motif. Some terms may reflect broader or cross-kingdom annotations, but the strongest signal points to plant glycoprotein\u2013glycan biology.","confidence":"High","size":25,"edges":59,"triangles":81,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":9},{"id":"GO:0080147","count":8},{"id":"GO:0001744","count":8},{"id":"GO:0048354","count":8},{"id":"GO:0042248","count":8}]},{"hash":"1289602838041277381","title":"Neural development and synaptic localization","description":"The cluster prominently features GO terms tied to nervous system development, dendritic spine morphogenesis, and receptor localization to synapse, all pointing to neuronal differentiation and synaptic organization. Additional terms about Golgi and centrosome-related localization suggest protein trafficking relevant to synapse formation, supporting a neural-development/synaptic-focus theme.  ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0097120","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0051683","count":1}]},{"hash":"940486094476777068","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039702","count":2}]},{"hash":"67846942771222272","title":"Synaptic organization and signaling","description":"This cluster is centered on synapse structure and signaling: postsynaptic density clustering, vesicle trafficking, active zone cytoskeleton, and receptor recycling. Some terms about retina and bone development may reflect broader developmental roles, but the strong representation of synaptic organization terms makes \u201cSynaptic organization and signaling\u201d a good label.","confidence":"High","size":25,"edges":292,"triangles":2126,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0002087","count":15},{"id":"GO:0002076","count":15},{"id":"GO:0060041","count":15},{"id":"GO:0008285","count":12},{"id":"GO:0006366","count":11}]},{"hash":"1051886475074400448","title":"Synaptic Vesicle Cycling and Developmental Signaling","description":"The most represented GO terms center on regulation of synaptic vesicle endocytosis and exocytosis, pointing to neural synaptic function. Supporting terms describe neural/vascular development and signaling pathways (retina layer formation, branching in blood vessel morphogenesis, Wnt calcium-modulating pathway, calcineurin-NFAT signaling), suggesting a cohesive theme of developmental signaling in neural and vascular contexts. A term about polysaccharide catabolic process is less clearly connected. Overall, the cluster seems to reflect coordinated regulation of synaptic vesicle dynamics together with broader developmental signaling.","confidence":"Medium","size":25,"edges":46,"triangles":22,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":9},{"id":"GO:0010842","count":9},{"id":"GO:0000272","count":9},{"id":"GO:0051531","count":8},{"id":"GO:0010800","count":8}]},{"hash":"867897650224391618","title":"Vertebrate nephrogenesis and organ morphogenesis","description":"This cluster centers on kidney development (metanephric proximal/distal tubules, mesonephric duct development) and related organ morphogenesis processes, with additional signals of skeletal and vascular/immune morphogenesis (cartilage condensation, lymph vessel morphogenesis, leukocyte rolling, platelet activation). The dominant theme is embryonic organogenesis with a strong emphasis on nephrogenesis, though other morphogenetic terms are present.","confidence":"Medium","size":25,"edges":123,"triangles":494,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":16},{"id":"GO:0001502","count":16},{"id":"GO:0036303","count":15},{"id":"GO:0072287","count":15},{"id":"GO:0010572","count":15}]},{"hash":"327472722695272357","title":"Prokaryotic cell division and ribosome biogenesis","description":"The cluster features terms tied to ribosome biogenesis, small subunit assembly, and cell division processes (cell cycle and septum assembly), suggesting core growth and division machinery in prokaryotes. It also includes genome dynamics-related terms (DNA transposition, conjugation), which can accompany growth phases in bacteria, with additional stress-response modifiers (salt and amino acid starvation) that modulate these processes. Overall, it points to a theme of bacterial growth coupled with genome dynamics rather than a single specialized pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0000747","count":2},{"id":"GO:1901001","count":2}]},{"hash":"898879377269798329","title":"Schwann cell development and PNS myelination","description":"The top terms strongly point to peripheral nervous system myelination and Schwann cell development (myelination in PNS and Schwann cell development), with NF-kappaB/NFAT signaling suggesting regulatory pathways in glial cells. While some terms touch on broader developmental or immune signaling, the core signals consistently align with Schwann cell biology and PNS myelination.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0043029","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0051531","count":4},{"id":"GO:1903244","count":4}]},{"hash":"1554627463957184050","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043123","count":7},{"id":"GO:0006469","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0045921","count":4},{"id":"GO:0002755","count":4}]},{"hash":"2155327666735839301","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around differentiation and morphogenesis during embryonic development\u2014trophoblast giant cell differentiation, placental development, left-right patterning, cartilage morphogenesis, endocrine system development, and pancreatic cell development\u2014along with an EMT-related process in heart formation. While a couple of terms (mRNA splicing, protein ubiquitination) reflect general cellular machinery, the dominant signal is embryonic tissue specification and organ patterning, suggesting proteins involved in developmental regulation rather than a single functional module. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060972","count":5}]},{"hash":"962334228072903086","title":"DNA replication and repair cluster","description":"The terms strongly point to genome maintenance: DNA replication, nucleotide-excision repair, double-strand break repair via classical NHEJ, and translesion synthesis are classic DNA repair processes. Ancillary terms related to RNA processing and intracellular transport appear, but the dominant signal ties to genome integrity maintenance, so this label best captures the cluster.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071035","count":2},{"id":"GO:0042276","count":2},{"id":"GO:0006297","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0097680","count":2}]},{"hash":"1115753577767697337","title":"Kidney and Lymphatic Morphogenesis","description":"The top GO terms cluster around developmental morphogenesis, especially metanephric kidney development (proximal/distal tubule, mesonephric duct) and lymphatic vessel morphogenesis, indicating a coordinated program for kidney and lymphatic formation. Some terms relating to immune cell trafficking and cellular stress appear but are secondary to the core kidney/lymphatic developmental theme.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0036303","count":20},{"id":"GO:0072287","count":20},{"id":"GO:0010572","count":20},{"id":"GO:0072218","count":20},{"id":"GO:0090403","count":20}]},{"hash":"1327654755272653716","title":"Unknown","description":"The top GO terms span immune activation (complement lectin pathway, leukocyte rolling, response to fungal origin, arachidonate signaling) and organ morphogenesis (metanephric kidney structures, mesonephric/lymphatic development), with no single cohesive function uniting these terms, so a well-defined cluster label isn\u2019t apparent.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0090238","count":7},{"id":"GO:0036303","count":6},{"id":"GO:0072287","count":6},{"id":"GO:0010572","count":6}]},{"hash":"1833810705158195683","title":"Apoptosis and cellular stress signaling","description":"The top GO terms point to apoptosis-related processes (extrinsic apoptotic signaling, mitochondrial fragmentation in apoptosis, and suppression of host apoptosis) and stress responses (unfolded protein response, hypoxia, and glucose starvation). While there are a few cell-cycle or growth-related terms (cell division, fertilization, osteoblast proliferation), the dominant theme is cell death signaling and cellular stress pathways.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytokinesis","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0097192","count":3},{"id":"GO:0009566","count":3},{"id":"GO:0042149","count":3},{"id":"GO:1903896","count":3}]},{"hash":"1503478718279746274","title":"Signaling and cytoskeleton regulation","description":"The terms emphasize modulation of signaling (tyrosine phosphorylation, GTPase activity), actin dynamics (Arp2/3\u2013mediated nucleation), and related cellular processes (mitotic cell cycle, cytoplasm-to-vacuole targeting), with auxiliary references to transcription and nuclear transport. This suggests a cohesive theme around how cells regulate signaling and the cytoskeleton, with links to cell cycle and transport.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0032258","count":2},{"id":"GO:0000278","count":2}]},{"hash":"232589935271978867","title":"Embryonic Development and Lineage Differentiation","description":"This cluster centers on developmental processes, including in utero embryonic development, neuron maturation, and differentiation of multiple lineages (erythrocyte and granulocyte). While there are immune and transcriptional regulation signals present, the dominant theme is embryonic development and cell differentiation across lineages, rather than a single specific pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":7},{"id":"GO:0042551","count":7},{"id":"GO:0001701","count":7},{"id":"GO:0055114","count":7},{"id":"GO:0032496","count":7}]},{"hash":"144304232145120765","title":"Developmental transcriptional regulation and organ morphogenesis","description":"The cluster shows strong enrichment for transcriptional regulation by RNA polymerase II (both negative and positive regulation), plus organ development and morphogenesis terms (midbrain development, pancreas development/morphogenesis, tissue remodeling, growth), suggesting a core role in developmental gene regulation and organ formation. Some metabolic/immune response terms appear, but do not override the primary theme. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0032496","count":10},{"id":"GO:0030901","count":10},{"id":"GO:0045944","count":8},{"id":"GO:0035264","count":8}]},{"hash":"692140393163426892","title":"IL-1\u2013NF-\u03baB Immune Activation","description":"This cluster centers on immune signaling: cellular response to interleukin-1, T cell costimulation and apoptotic processes, and activation of NF-\u03baB, suggesting IL-1\u2013driven, NF-\u03baB\u2013mediated T cell\u2013immune activation; the presence of platelet activation and adhesion terms likely reflects inflammatory cell interactions and tissue remodeling associated with immune responses.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":4},{"id":"GO:0031295","count":3},{"id":"GO:0010812","count":3},{"id":"GO:0030168","count":3},{"id":"GO:0034116","count":3}]},{"hash":"1660344566413079808","title":"Tissue and organ morphogenesis with immune signaling","description":"This cluster's top GO terms cluster around morphogenesis and tissue development (cartilage condensation; lymph vessel morphogenesis; metanephric development), with additional immune-related activity (complement pathway) and adhesion regulation. While not all terms point to a single function, the recurring theme is developmental processes shaping tissues and organs, with supporting immune and cell interaction roles. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0071226","count":4},{"id":"GO:0051873","count":4},{"id":"GO:0060355","count":4}]},{"hash":"1157159732377985526","title":"Unknown","description":"The terms are highly heterogeneous, spanning viral release, bacterial cell-wall catabolism, membrane potential, cytoskeletal assembly, and various developmental processes, with no unifying function. The cluster has no edges or triangles, and the GO annotations do not point to a single coherent pathway, so there is no reliable thematic label beyond Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":2},{"id":"GO:0016998","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0060081","count":2},{"id":"GO:0043149","count":2}]},{"hash":"1322736874685035328","title":"Embryonic and organ development","description":"This cluster is enriched for diverse developmental processes across multiple tissues (heart, eye, placenta, gonads, prostate, habenula, etc.), including organogenesis and morphogenesis. The presence of muscle development (myoblast proliferation) and transcriptional regulation terms further supports a unifying theme of developmental programs driving tissue formation, rather than a single tissue-specific function.","confidence":"High","size":24,"edges":63,"triangles":10,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":9},{"id":"GO:0021986","count":9},{"id":"GO:0001890","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0060527","count":8}]},{"hash":"931258890215604070","title":"Estrogen-Responsive Anti-inflammatory Vascular Regulation","description":"The terms converge on dampening inflammatory processes (IL-1\u03b2 production, acute inflammation, leukocyte proliferation, smooth muscle chemotaxis) and modulation of signaling (ERK cascade), with added oxidative detoxification and estradiol response, pointing to a cohesive role in estrogen-influenced vascular inflammation and stress responses.","confidence":"High","size":24,"edges":275,"triangles":2002,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":24},{"id":"GO:0032355","count":23},{"id":"GO:0070373","count":23},{"id":"GO:1904706","count":23},{"id":"GO:1905804","count":23}]},{"hash":"460380811523057024","title":"Mitochondrial Translation and Respiration","description":"The cluster is strongly enriched for translation-related terms (translation, negative regulation of translation, and rRNA base methylation) alongside mitochondrial respiratory chain components (electron transport chain and Complex I assembly). This points to a cohesive module involved in mitochondrial protein synthesis and energy production, i.e., mitochondrial translation machinery linked to respiration. Peripheral terms such as brain development or obsolete GO terms are less central to the main theme.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0010259","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0017148","count":2}]},{"hash":"527615204203767377","title":"Immune transcriptional regulation in macrophages","description":"The cluster centers on transcription by RNA polymerase II and DNA-templated transcription, with immune-related terms like macrophage differentiation, cellular response to interleukin-4, and MHC class II biosynthesis. This combination suggests proteins that regulate gene expression in macrophages and other immune cells, linking transcriptional control to immune signaling and antigen presentation, as well as tissue repair processes.","confidence":"High","size":24,"edges":272,"triangles":1939,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0045348","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0071353","count":7},{"id":"GO:0035470","count":7}]},{"hash":"241487792013902195","title":"DNA Damage Response and Repair","description":"The cluster shows strong representation of DNA metabolism and stress response processes: base-excision repair, DNA replication, DNA recombination, and apoptotic process, along with cellular responses to hydrogen peroxide and xenobiotic stimuli, which together point to genome maintenance under oxidative/detox stress. Some obsolete terms may be noise but do not disrupt the overall theme of DNA damage response.","confidence":"High","size":24,"edges":220,"triangles":1049,"max_degree":22,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0070301","count":7},{"id":"GO:0042493","count":7},{"id":"GO:0006310","count":7},{"id":"GO:0007568","count":7},{"id":"GO:0006284","count":7}]},{"hash":"1870533264460924052","title":"Biosynthesis of lipids, steroids, and secondary metabolites","description":"These proteins appear enriched for diverse biosynthetic processes, including lipid/sphingolipid metabolism, steroid (estrogen, glucocorticoid) biosynthesis, and various secondary metabolite pathways (antibiotics, tropane alkaloids, melanin, etc.). The unifying theme is broad metabolite production rather than a single pathway, justifying a label around broad biosynthesis activity.","confidence":"High","size":24,"edges":102,"triangles":188,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":17},{"id":"GO:0055114","count":15},{"id":"GO:0042619","count":14},{"id":"GO:0030148","count":13},{"id":"GO:0006703","count":13}]},{"hash":"1501551266258840037","title":"Endosomal trafficking and synaptic signaling","description":"This cluster is dominated by GO terms describing vesicle trafficking and sorting (Golgi to endosome transport, endocytosis, early endosome to Golgi transport, multivesicular body sorting) and, in parallel, neuronal communication (excitatory postsynaptic potential, regulation of long-term synaptic plasticity). Although there are also terms related to immune signaling and growth, the strongest and most coherent theme across the proteins is endosomal/vesicle transport with synaptic function, justifying this label.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0050852","count":5},{"id":"GO:0048169","count":5},{"id":"GO:0051291","count":5},{"id":"GO:0071985","count":5}]},{"hash":"1840040406507487583","title":"Ribosome biogenesis and translation","description":"The terms cluster around protein synthesis: translation, ribosome biogenesis (including small subunit), tRNA processing/modification, and SRP-dependent targeting to membranes, which together define the ribosome/translation machinery and its assembly. Cell cycle/division terms may reflect growth coordination but do not outweigh the core translation theme.","confidence":"High","size":24,"edges":95,"triangles":255,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0007049","count":4},{"id":"GO:0006400","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3}]},{"hash":"1055613937290088369","title":"Actin-driven vesicle trafficking and organelle assembly","description":"The top GO terms show a strong emphasis on actin filament polymerization and regulation of vesicle exocytosis (synaptic and exosomal), as well as organelle biogenesis (melanosomes) and trafficking pathways (CVT). Additional terms touch on developmental and cellular differentiation contexts (cochlea morphogenesis, kidney size, macrophage differentiation), all of which commonly rely on actin-driven cytoskeletal remodeling and vesicle transport. Together, they point to a cohesive theme of cytoskeletal control of vesicle movement and organelle assembly across development and immune contexts.","confidence":"Medium","size":24,"edges":110,"triangles":247,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090103","count":24},{"id":"GO:0030838","count":24},{"id":"GO:1903542","count":24},{"id":"GO:2000300","count":24},{"id":"GO:0032258","count":24}]},{"hash":"1306907988160742359","title":"Ribosome Biogenesis and rRNA Maturation","description":"Top GO terms strongly indicate rRNA maturation (LSU/SSU/5.8S) and ribosomal large subunit biogenesis, supported by related RNA processing activities (methylation, splicing, transcription). This suggests proteins cluster around ribosome assembly and RNA maturation pathways, with a few developmental terms likely reflecting broader roles in multicellular organisms.","confidence":"High","size":24,"edges":229,"triangles":1356,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000463","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0000466","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0006351","count":5}]},{"hash":"1324004318366091411","title":"Metanephric kidney morphogenesis","description":"The top GO terms are dominated by metanephric kidney development and tubule morphogenesis (proximal/distal tubules, mesonephric duct), with several explicit references to metanephric development. A few terms touch on immune or vascular processes, but the strongest signal across the cluster points to kidney morphogenesis as the core theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":12},{"id":"GO:0036303","count":11},{"id":"GO:0072287","count":11},{"id":"GO:0010572","count":11},{"id":"GO:0072218","count":11}]},{"hash":"1455418862436538148","title":"Neuronal spine morphogenesis and synaptic signaling","description":"These terms cluster around actin cytoskeleton remodeling driven by Rho signaling, promoting dendritic spine formation and lamellipodium-like structures, along with adhesion components at synapses (adherens/tight junctions) that support excitatory neurotransmission. The inclusion of excitatory postsynaptic potential regulation and social/grooming behaviors suggests involvement in neural circuits and synaptic plasticity.","confidence":"High","size":24,"edges":248,"triangles":1488,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0030036","count":6},{"id":"GO:0046328","count":5},{"id":"GO:0060997","count":5},{"id":"GO:0070830","count":5}]},{"hash":"1182992142542001154","title":"Diverse Solute Transporters","description":"These proteins share strong GO signals for transmembrane transport of a wide range of substrates (sialic acid, nitrate, galactose, arabinose, fucose, vitamins, and related compounds) and vesicular neurotransmitter loading, indicating a common function as membrane transporters handling diverse solutes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0035461","count":2}]},{"hash":"378732196938867485","title":"Rho/Rac-Driven Immune Signaling","description":"The top GO terms point to regulation of Rho and Rac pathways and lamellipodium (actin) assembly, coupled with immune-related processes such as NK T cell differentiation and dendritic cell apoptosis, suggesting a coordinated role of cytoskeletal remodeling in immune signaling and cell interactions, with ubiquitination as a regulatory layer.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:2001275","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0030032","count":4},{"id":"GO:0098761","count":4},{"id":"GO:0071260","count":4}]},{"hash":"1978244174069953359","title":"Calcium and GPCR signaling in cardiac and neural development","description":"Top GO terms indicate calcium regulation and GPCR signaling with links to heart development and neural guidance, suggesting a module of proteins involved in calcium- and GPCR-mediated signaling during cardiac and neural development. The label reflects the shared functional theme across the terms.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060347","count":3},{"id":"GO:0010573","count":3},{"id":"GO:0070528","count":3},{"id":"GO:0036514","count":2},{"id":"GO:2000852","count":2}]},{"hash":"2091274514351968742","title":"Embryonic development and cell cycle control","description":"The top GO terms reveal strong signals for embryonic development (cranial skeletal system, dorsal root ganglion, metanephros morphogenesis) along with regulation of the cell cycle, DNA damage response, and intracellular transport/localization. This suggests a cluster of proteins coordinating developmental programs with cell cycle progression and genome maintenance, including nuclear import and microtubule-associated transport. Therefore, a concise label capturing both developmental and cell-cycle aspects is appropriate.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":17},{"id":"GO:0007050","count":16},{"id":"GO:0016477","count":15},{"id":"GO:0006607","count":15},{"id":"GO:0003338","count":15}]},{"hash":"2134428214689054218","title":"Complement Activation Pathway Proteins","description":"The top GO terms are dominated by complement activation via lectin and classical pathways, indicating the cluster centers on immune complement activity. Other terms are sporadic and less coherent (tendon development, aldosterone secretion, podocyte development, channel clustering, cuticle development, etc.), suggesting some annotation noise. Overall, the common thread is involvement in the complement system.","confidence":"Medium","size":24,"edges":30,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0006958","count":3},{"id":"GO:0045715","count":2},{"id":"GO:0035989","count":2},{"id":"GO:2000860","count":2}]},{"hash":"1659842434920064053","title":"Developmental signaling and protein modification","description":"These proteins are enriched for multicellular organism development terms (including neural tube formation, kidney development, and ommatidial rotation) and for post-translational regulation (ubiquitination and phosphorylation, including ERK signaling). The combination implies a module coordinating developmental signaling with protein modification and trafficking, so a label focusing on developmental signaling and PTMs fits well.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0016318","count":2},{"id":"GO:0001841","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0010801","count":2}]},{"hash":"405343004097482511","title":"Angiogenesis and vascular regulation","description":"The cluster shows enrichment for positive regulation of angiogenesis and vasoconstriction, along with terms tied to vascular homeostasis and development (e.g., Wnt signaling, blood pressure regulation, embryonic development), suggesting a cohesive theme around endothelial signaling and vascular formation; some terms are broader or ancillary but do not contradict this vascular-focused view.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":4},{"id":"GO:0045907","count":3},{"id":"GO:0042593","count":3},{"id":"GO:0060828","count":3},{"id":"GO:0003050","count":3}]},{"hash":"913941294755542105","title":"Coagulation, fibrinolysis, and vascular remodeling","description":"The Top Terms show strongest enrichment for coagulation and fibrinolysis (fibrinolysis, plasminogen activation, blood coagulation) and vascular remodeling processes (angiogenesis, endothelial barrier establishment). Lectin pathway complement activation further links to immune-vessel interactions. Some terms (midbrain development, response to lipopolysaccharide, transcription regulation) appear less central and may reflect pleiotropy or broader regulatory roles, but the dominant signal centers on hemostasis and vascular dynamics.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":9},{"id":"GO:0045766","count":8},{"id":"GO:0001867","count":8},{"id":"GO:0031639","count":8},{"id":"GO:0071333","count":6}]},{"hash":"1542074457717780220","title":"Nervous system development and axon guidance","description":"The top terms cluster around neural development, axon guidance (Roundabout signaling), and neuronal signaling pathways (ERK/PI3K), with related motor behaviors and balance, suggesting a theme of nervous system development and neural connectivity rather than peripheral processes. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0000186","count":2},{"id":"GO:0050885","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0043931","count":2}]},{"hash":"2216290343486804597","title":"Neuronal adhesion and synapse assembly","description":"The top GO terms show strong enrichment for cell-cell adhesion (heterophilic and homophilic) and synapse-assembly\u2013related processes, along with nervous system development, indicating proteins involved in neuronal connectivity and synapse formation; other developmental terms appear less central but may reflect broader roles in development.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":10},{"id":"GO:0007156","count":9},{"id":"GO:0051965","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0048105","count":7}]},{"hash":"2285953397469434572","title":"Acetyl-CoA Linked Lipid Metabolism","description":"Most terms point to acetyl-CoA\u2013driven lipid metabolism: fatty acid biosynthesis, long-chain fatty acid metabolism, and acetyl-CoA formation from acetate. Phenylpropanoid metabolism also ties to acetyl-CoA\u2013derived precursors. A few terms (seed germination regulation, bile acid metabolism) are peripheral or cross-species artifacts, but the central theme is acetyl-CoA\u2013linked lipid pathways.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":5},{"id":"GO:0010030","count":5},{"id":"GO:0019654","count":5},{"id":"GO:0090410","count":5},{"id":"GO:0043041","count":5}]},{"hash":"2119306073433461325","title":"Nuclear transport and chromatid dynamics","description":"The proteins show strong enrichment for nuclear import/export processes (NLS-bearing protein import, ribosomal protein import, RNA import, mRNA export, nuclear pore complex assembly) together with chromatid cohesion and separation terms (meiotic cohesion, mitotic separation), indicating a cluster centered on nuclear transport machinery and chromosome segregation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051754","count":5},{"id":"GO:0006607","count":4},{"id":"GO:0060188","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000060","count":4}]},{"hash":"1934043920210026380","title":"Ribosome Biogenesis and RNA Processing","description":"The cluster\u2019s top GO terms are dominated by ribosome biogenesis (GO:0042254), ribosomal large subunit biogenesis (GO:0042273), and rRNA processing (GO:0000447), with DNA-templated transcription (GO:0006351) and mitotic cell cycle (GO:0000278) also represented. This combination points to nucleolar, growth-related functions centered on assembling ribosomes and processing rRNA, with broader ties to transcription and cell-cycle progression in proliferating cells. Unknown terms like development or cilium assembly may reflect broader cellular contexts rather than core functions of the cluster.","confidence":"High","size":24,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0000447","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0043966","count":4},{"id":"GO:0006351","count":4}]},{"hash":"1685985033592697040","title":"Deubiquitinases Regulating Signaling and Apoptosis","description":"The top GO terms cluster around deubiquitination across multiple linkage types (K6, K63, K27, K48) and negative regulation of signaling pathways (CD40, IL-1\u03b2) as well as apoptosis, pointing to a group of proteins that modulate ubiquitin signaling to control immune signaling and cell death. Some terms related to neuronal signaling and ion homeostasis are present but appear less central, with the dominant theme being ubiquitin-mediated regulation of signaling and apoptosis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000352","count":3},{"id":"GO:1902042","count":3},{"id":"GO:0006883","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0044313","count":2}]},{"hash":"258343967380919780","title":"Ubiquitin-Proteasome Pathway and Histone Regulation","description":"This cluster is dominated by ubiquitination-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, K6- and K48-linked ubiquitination) and histone catabolic/regulatory terms, suggesting roles in protein turnover and chromatin remodeling. The presence of terms related to JNK signaling and TNF pathways indicates stress-response connections that often involve ubiquitin tagging. Overall, the proteins likely function together in ubiquitin-mediated degradation with chromatin regulation as a co-theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0051865","count":8},{"id":"GO:0085020","count":8},{"id":"GO:1903265","count":7},{"id":"GO:0036205","count":7}]},{"hash":"1547763561936359992","title":"Mitochondrial Translation and Fatty Acid Oxidation","description":"Based on the GO terms, the cluster is enriched for mitochondrial translation and fatty acid beta-oxidation, suggesting proteins involved in mitochondrial protein synthesis together with energy metabolism through lipid catabolism. The explicit mitochondrial translation term (GO:0032543) and beta-oxidation terms (GO:0033539, GO:0033540) provide a cohesive theme, while some terms like response to antibiotic or obsolete processes may be incidental noise. Overall, this label reflects the core mitochondrial-centric functions of the cluster.","confidence":"High","size":24,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0032543","count":2},{"id":"GO:0018189","count":2}]},{"hash":"322279065771395876","title":"DNA Repair and Genome Maintenance","description":"This cluster is strongly enriched for DNA-directed processes: base-excision repair and DNA recombination, along with DNA catabolic processes, indicating a core function in DNA damage repair and genome maintenance. While there are additional terms related to redox homeostasis and RNA stability, the dominant signal centers on DNA repair pathways, suggesting the proteins work together to preserve genomic integrity.","confidence":"High","size":24,"edges":264,"triangles":1775,"max_degree":23,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":7},{"id":"GO:0006310","count":7},{"id":"GO:2001153","count":6},{"id":"GO:1903507","count":6},{"id":"GO:0046856","count":6}]},{"hash":"468585659632537072","title":"Neuronal metabolism and development","description":"The GO terms show core energy pathways (glucose metabolism, glycolysis, TCA cycle) and mitochondrial-related processes, alongside neural development and migration terms (cerebellar cortex development, tangential migration, neuron apoptotic process). This suggests a cluster of proteins linked to neuronal energy metabolism with CNS development processes, rather than a solely metabolic or purely developmental group.","confidence":"Medium","size":24,"edges":270,"triangles":1897,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0051402","count":2},{"id":"GO:0061732","count":2}]},{"hash":"1489754439527841276","title":"Immune-coagulation and tissue regeneration","description":"The cluster is enriched for complement activation (lectin pathway), proteolysis, and platelet activation, with additional signals for cell migration and skeletal muscle tissue regeneration. This points to proteins involved in early immune/coagulation responses that drive tissue repair and remodeling after injury. Some terms are obsolete, but the core theme is immune/coagulation linked to tissue regeneration.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0010572","count":3},{"id":"GO:0016477","count":2},{"id":"GO:2001275","count":2}]},{"hash":"567209001123540892","title":"Cell signaling and differentiation regulators","description":"The top GO terms point to regulation and execution of differentiation across multiple lineages (fat cell, oligodendrocyte, follicular dendritic cells) and to modulation of signaling processes (intracellular signal transduction, GPCR signaling, GTPase activity regulation, kinase activity regulation, ubiquitination, and pinocytosis). The combination suggests these proteins function as regulators of signaling pathways and cellular differentiation rather than a single, shared pathway. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045444","count":7},{"id":"GO:0035556","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0048709","count":7},{"id":"GO:0048549","count":7}]},{"hash":"1873434421277434915","title":"Embryogenesis and organ morphogenesis","description":"This cluster centers on embryonic development and tissue morphogenesis, with terms for placental formation, neural tube closure, left-right patterning, EMT in heart cushions, cartilage and endocrine organ development.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060972","count":3}]},{"hash":"367091563131045380","title":"Vesicle trafficking and ER-Golgi transport","description":"The top GO terms point to intracellular protein transport and vesicle trafficking, including COPII-coated vesicle loading, ER-to-Golgi vesicle transport, and plasma membrane to endosome transport, plus regulation of vacuole fusion. These consistently indicate a core function in the secretory pathway and vesicular transport, with other terms likely reflecting broader or context-dependent roles. Confidence: High","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0098586","count":2},{"id":"GO:0032715","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0032889","count":1}]},{"hash":"474469361192387766","title":"Steroid Lipid Biosynthesis and Transport","description":"This cluster is dominated by GO terms related to steroid hormone production and lipid trafficking\u2014progesterone biosynthesis, glucocorticoid metabolism, cholesterol transport, bile acid biosynthesis, and ceramide transport\u2014suggesting a common theme of lipid metabolism and steroid biosynthesis, with other development terms possibly reflecting downstream hormonal effects.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006701","count":2},{"id":"GO:0032367","count":2},{"id":"GO:0070859","count":2},{"id":"GO:0008211","count":2},{"id":"GO:0080060","count":2}]},{"hash":"1049471190619381977","title":"Cerebellar cortex development and axon regeneration","description":"Dominated by cerebellar cortex formation and Bergmann glial differentiation, with regulation of axon regeneration as a core function, this cluster centers on cerebellar neural development and connectivity. Secondary signals such as insulin signaling and cell cycle regulation are present but do not override the central cerebellar theme.","confidence":"High","size":23,"edges":125,"triangles":293,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048679","count":23},{"id":"GO:2001275","count":23},{"id":"GO:0021697","count":23},{"id":"GO:0060020","count":23},{"id":"GO:0050852","count":23}]},{"hash":"632168134340145549","title":"Developmental transcriptional regulation","description":"Most terms point to transcription by RNA polymerase II and DNA-templated transcription, with several development- and differentiation-related terms (endocrine pancreas development, osteoblast differentiation, outflow tract morphogenesis). This suggests a cluster of proteins involved in controlling gene expression during development and tissue specification, rather than a single pathway, though immune/stress-related terms are present as less central signals.","confidence":"High","size":23,"edges":159,"triangles":429,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0006351","count":8},{"id":"GO:0071353","count":7},{"id":"GO:0045669","count":7},{"id":"GO:1990440","count":7}]},{"hash":"436767675184848290","title":"Axon Guidance and Planar Polarity Signaling","description":"The cluster is enriched for axon guidance terms (anterior/posterior guidance, dopaminergic neuron guidance) and planar polarity signaling (planar polarity pathway components and localization in establishment of polarity), with supporting terms related to cell adhesion and remodeling. Though there are a few terms on apoptotic cell recognition and satellite cell biology, the dominant theme centers on neural wiring and cell polarity coordination.","confidence":"High","size":23,"edges":230,"triangles":1348,"max_degree":22,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0033564","count":10},{"id":"GO:0036514","count":10},{"id":"GO:0034446","count":10},{"id":"GO:0014816","count":10},{"id":"GO:0043654","count":10}]},{"hash":"423873161801060387","title":"Neuronal synapse formation and behavior","description":"The cluster is enriched for terms tied to synapse development and function (dendritic spine morphogenesis, synapse organization, receptor clustering, excitatory postsynaptic potential) alongside behavioral and sensory terms (vocalization, social behavior, grooming, sensory perception of sound). This points to a cohesive module of proteins governing synaptic connectivity and the neural circuits underlying social communication and behavior.","confidence":"High","size":23,"edges":39,"triangles":27,"max_degree":9,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0060997","count":15},{"id":"GO:0071625","count":12},{"id":"GO:0046328","count":10},{"id":"GO:0050808","count":10},{"id":"GO:2000009","count":10}]},{"hash":"1600719212944474493","title":"Retroviral DNA replication and integration","description":"The cluster centers on processes typical of retroviral lifecycles: viral entry into the host, reverse transcription (RNA-templated DNA synthesis), and integration of viral DNA into the host genome, culminating in proviral latency. Additional terms about DNA replication/recombination and host-symbiont interactions reinforce a theme of intracellular viral genome maintenance and latency within host cells.","confidence":"High","size":23,"edges":150,"triangles":485,"max_degree":19,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0006260","count":5},{"id":"GO:0043137","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4}]},{"hash":"2222454272370121303","title":"Dopaminergic and Adrenergic GPCR\u2013cAMP Signaling","description":"The top GO terms center on dopamine receptor signaling and adenylate cyclase\u2013activating/adrenergic receptor signaling, all converging on cAMP pathways, with supporting terms for phototransduction and heart development. This suggests a cohesive cluster of proteins involved in GPCR-mediated regulation of cAMP, especially via dopaminergic and adrenergic receptors. ","confidence":"High","size":23,"edges":136,"triangles":362,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060158","count":22},{"id":"GO:0007603","count":22},{"id":"GO:0010513","count":22},{"id":"GO:0071880","count":22},{"id":"GO:0043950","count":22}]},{"hash":"438919140141416578","title":"Actin Cytoskeleton Remodeling","description":"This cluster is dominated by GO terms tied to actin dynamics, including actin filament polymerization, bundle assembly, and cortical patch assembly/localization, as well as processes like phagocytosis and platelet aggregation that depend on actin remodeling to drive cell shape changes and membrane activities. While a couple terms relate to chromatin, the overarching theme is actin cytoskeleton organization and remodeling.","confidence":"High","size":23,"edges":98,"triangles":315,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032508","count":12},{"id":"GO:0006909","count":10},{"id":"GO:0071963","count":10},{"id":"GO:0051017","count":10},{"id":"GO:0006348","count":10}]},{"hash":"420654273443328317","title":"Unknown","description":"The terms span neural development (oligodendrocyte differentiation, enteric nervous system development), calcium signaling (release of sequestered calcium into cytosol), chromosome/nuclear maintenance (telomere localization and regulation) and RNA processing (piRNA processing), plus cell division (spindle assembly). There is no single, coherent function tying these diverse terms together, so a unique, representative cluster name cannot be assigned beyond Unknown.","confidence":"","size":23,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048709","count":4},{"id":"GO:0048484","count":3},{"id":"GO:0051209","count":3},{"id":"GO:0070198","count":3},{"id":"GO:1904357","count":3}]},{"hash":"2293914449008418358","title":"Ribosome biogenesis and cell division","description":"The top GO terms cluster around ribosome production and function (cytoplasmic translation, ribosome biogenesis, ribosomal subunit export, tRNA modification) alongside cell cycle and division processes (cell division, cell cycle, cell septum assembly). This combination suggests a coordinated role in protein synthesis machinery and proliferation.","confidence":"High","size":23,"edges":163,"triangles":552,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0000747","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0002181","count":7},{"id":"GO:0000055","count":7}]},{"hash":"2097366161103213305","title":"Immune\u2013Metabolic Signaling","description":"The cluster shows strong representation of immune-related terms (defense response to bacterium, response to lipopolysaccharide, cytolysis) alongside metabolic and signaling terms (electron transport chain, regulation of membrane potential, GPCR signaling, diet-induced thermogenesis, blood pressure). This suggests proteins that link immune defense with cellular energy metabolism and broader signaling pathways, rather than a single narrow function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019835","count":10},{"id":"GO:0032496","count":10},{"id":"GO:0014063","count":10},{"id":"GO:0045777","count":10},{"id":"GO:0002024","count":10}]},{"hash":"248995949009919789","title":"mRNA processing and translation initiation regulation","description":"The cluster is enriched for GO terms covering translation initiation and its regulation (including preinitiation complex formation, translation reinitiation, and IRES-dependent viral initiation) together with spliceosome-mediated mRNA processing (cis splicing, alternative splicing regulation). This points to a coherent module where mRNA maturation and control of translation initiation are linked, justifying a label that reflects both processes.","confidence":"High","size":23,"edges":212,"triangles":1099,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":16},{"id":"GO:0001731","count":15},{"id":"GO:0006446","count":15},{"id":"GO:0075522","count":15},{"id":"GO:0075525","count":15}]},{"hash":"1258032048737244064","title":"Unknown","description":"The top GO terms span angiogenesis, glial growth, MHC I antigen processing, differentiation, leukotriene synthesis, angiotensin maturation, cell signaling, symbiont entry, and development, which do not converge on a single clear function or pathway for this protein set. This suggests a mixed or context-dependent cluster rather than a cohesive theme.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0045766","count":4},{"id":"GO:0042066","count":4},{"id":"GO:0019885","count":3},{"id":"GO:0030154","count":3},{"id":"GO:0019370","count":3}]},{"hash":"1633435122556558168","title":"Neural Development Signaling Regulation","description":"Most terms point to neural development and associated signaling pathways (neuron development, retinal ganglion cell axon guidance, ERK cascade, GTPase activity, phosphorylation). The presence of NF-kappaB regulation and IL-6 modulation aligns with signaling control in neural contexts, while a couple terms reflect metabolic aspects that can accompany neural activity. Overall, the cluster appears centered on neural development and its signaling regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":4},{"id":"GO:0070374","count":3},{"id":"GO:0090648","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0031290","count":2}]},{"hash":"1833207884274026820","title":"Neural development and axon guidance","description":"The cluster\u2019s top GO terms are dominated by nervous system development and axon pathfinding, including branchiomotor neuron axon guidance, axonal fasciculation, trigeminal nerve structural organization, ventral trunk neural crest cell migration, and multicellular organism development. While a few terms touch on other processes (angiogenesis, sarcomere organization, thyroid hormone response, megakaryocyte development, symbiont entry), the core signal points to neural development and neural crest\u2013driven nerve organization.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097067","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0021785","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0007413","count":2}]},{"hash":"772633736216842816","title":"GPCR-Mediated Pain Signaling and Calcium Entry","description":"The cluster centers on GPCR signaling and nociception, with multiple terms for detecting chemical and mechanical pain and for calcium influx across the plasma membrane, suggesting a coherent GPCR\u2013calcium\u2013pain signaling module. Additional terms for kinase regulation and cell migration support a broader signaling context but do not override the primary theme.","confidence":"Medium","size":23,"edges":27,"triangles":7,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":3},{"id":"GO:0050968","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0050966","count":3},{"id":"GO:0002268","count":2}]},{"hash":"1203320815874747559","title":"Developmental signaling and neurogenesis","description":"This cluster centers on developmental processes across multiple organs (kidney, heart) and neural formation, highlighted by Hedgehog (Smoothened) and ROBO signaling, along with neurogenesis and synapse assembly, indicating a cohesive theme of developmental signaling guiding organogenesis and neural connectivity.","confidence":"High","size":23,"edges":191,"triangles":738,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0035385","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0050852","count":6}]},{"hash":"1671215153992343988","title":"Placental and Embryonic Organogenesis","description":"The terms cluster around embryonic development with strong emphasis on placental/trophoblast differentiation, endocrine system development, and organogenesis (including cartilage morphogenesis and left-right patterning), plus an EMT process in heart/valve formation, indicating a coherent theme of embryonic and placental development.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071287","count":3},{"id":"GO:0090394","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1237186806383205482","title":"Mitochondrial respiration and energy metabolism","description":"The cluster is dominated by terms tied to oxidative phosphorylation and mitochondrial energy production, including mitochondrial electron transport (cytochrome c to oxygen), aerobic respiration, and proton transmembrane transport. Cofactor biosynthesis for heme (porphyrin-containing compounds) and related metabolic processes support the respiratory chain, while phosphorylation/dephosphorylation suggests regulatory control of these pathways. Overall, the group centers on mitochondrial energy metabolism and respiration.","confidence":"High","size":23,"edges":250,"triangles":1709,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0046677","count":2},{"id":"GO:1902600","count":2}]},{"hash":"1520222243942078704","title":"Angiogenesis and Endothelial Cell Migration","description":"The cluster is enriched for GO terms focusing on vascular development and endothelial dynamics, including angiogenesis, endothelial cell migration, VEGF signaling effects, and angioblast migration, indicating a cohesive theme around blood vessel formation and vascular remodeling (despite one or two outliers like axonogenesis).","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904706","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0010735","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0043407","count":3}]},{"hash":"970191109180417148","title":"Neuronal Synaptic Plasticity and Cytoskeletal Remodeling","description":"This cluster shows enrichment in GO terms related to neuronal signaling and synaptic function (regulation of long-term neuronal synaptic plasticity; excitatory postsynaptic potential; sensory perception of touch; cochlea morphogenesis) and cytoskeletal and junctional processes (actin filament polymerization; stress fiber assembly; adherens junction organization). The convergence suggests proteins coordinating synaptic activity with actin remodeling and cell\u2013cell adhesion during neural development and sensory organ formation.","confidence":"Medium","size":23,"edges":19,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":3},{"id":"GO:0051496","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0090051","count":3},{"id":"GO:0035264","count":3}]},{"hash":"1020807932707715268","title":"ECM Remodeling and Proteolysis","description":"The cluster is dominated by terms tied to extracellular matrix degradation and basement membrane remodeling (basement membrane disassembly, collagen catabolic process, bradykinin catabolic, proteolysis-related terms), plus developmentally relevant processes like epithelial tube branching in lung morphogenesis. This pattern points to a cohesive theme of proteolytic remodeling of the ECM, with broader implications for development and tissue morphogenesis, rather than isolated signaling events. While some terms are broader (e.g., regulation of catalytic activity, neural/immune terms), the ECM proteolysis signal is strong and specific.","confidence":"High","size":23,"edges":243,"triangles":1575,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0050790","count":21},{"id":"GO:0034769","count":21},{"id":"GO:0010813","count":21},{"id":"GO:2000179","count":21},{"id":"GO:0051603","count":21}]},{"hash":"633664964539159265","title":"Cytoskeleton Remodeling and Cell Adhesion","description":"The cluster is enriched for GO terms related to cell adhesion, actin filament organization, lamellipodium assembly, and signaling pathways (HGF/Met and VEGF receptors) that drive cytoskeleton dynamics and cell movement. Although a couple of terms are unrelated or obsolete, the dominant theme ties to actin remodeling and adhesion signaling, suggesting a cohesive role in cytoskeleton-mediated cell adhesion and migration.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0048012","count":2},{"id":"GO:0048010","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0007015","count":2}]},{"hash":"2053568632168062103","title":"Steroid and lipid biosynthesis","description":"The cluster shows enrichment for multiple biosynthetic processes including sphingolipids, fatty acids, estrogens, glucocorticoids, and retinoic acid, pointing to a cohesive theme of lipid and steroid molecule biosynthesis; a few terms like melanin or plant alkaloid biosynthesis are peripheral but do not override the main lipid/steroid focus.","confidence":"High","size":23,"edges":124,"triangles":205,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0030148","count":11},{"id":"GO:0006703","count":11},{"id":"GO:0006710","count":11},{"id":"GO:0042438","count":11}]},{"hash":"1834041233194896530","title":"Amino acid catabolism and B6/NAD biosynthesis","description":"The cluster is dominated by GO terms related to amino-acid degradation (L-alanine, L-kynurenine, glyoxylate, pyruvate) and NAD biosynthesis via quinolinate, plus pyridoxine/vitamin B6 metabolism and related responses. This points to a cohesive theme around amino-acid flux and vitamin B6\u2013dependent pathways feeding into NAD biosynthesis, with Notch signaling appearing incidental rather than central. ","confidence":"Medium","size":23,"edges":243,"triangles":1575,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007219","count":10},{"id":"GO:0042853","count":10},{"id":"GO:0097053","count":10},{"id":"GO:0042866","count":9},{"id":"GO:0009436","count":9}]},{"hash":"1071326162013451550","title":"Nephron and lymphovascular morphogenesis","description":"The top GO terms cluster around metanephric nephron development (distal/ascending limb, proximal tubule, mesonephric duct) and lymphatic/vascular morphogenesis, with supporting immune-related processes (leukocyte rolling, complement activation, responses to fungal origin) and platelet activation. This suggests a coherent theme of kidney organogenesis coupled with vascular and immune remodeling, rather than a single isolated pathway. ","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":23},{"id":"GO:0036303","count":21},{"id":"GO:0072287","count":21},{"id":"GO:0010572","count":21},{"id":"GO:0072218","count":21}]},{"hash":"1824618547540125963","title":"Immune activation and inflammatory signaling","description":"These terms center on immune cell activation, cytokine production, and signaling pathways (STAT phosphorylation, NF-kappaB activity), with supportive hints of hematopoietic/vascular development (endothelial morphogenesis, megakaryocyte development). Overall, the cluster seems best described by immune activation and inflammatory signaling rather than a single specific pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042511","count":1},{"id":"GO:0001886","count":1},{"id":"GO:0035855","count":1},{"id":"GO:0050712","count":1},{"id":"GO:0002318","count":1}]},{"hash":"1086247928906345238","title":"Receptor Tyrosine Kinase Signaling and Cell Adhesion","description":"The cluster centers on cell-surface receptor signaling, including KIT signaling, with accompanying roles in cell adhesion and lysosome-associated trafficking. The presence of RTK-related downstream signaling terms (NF-kappaB, PI3K, PLC) and paranodal junction context supports a theme of membrane-initiated signaling coupled to cell\u2013cell contacts.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007166","count":2},{"id":"GO:0061462","count":2},{"id":"GO:0030913","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0007155","count":2}]},{"hash":"1853573825919766847","title":"DNA Damage Response and Checkpoint Signaling","description":"This cluster centers on cellular responses to DNA damage and replication stress, as shown by terms for mitotic/meiotic DNA damage checkpoints, nucleotide-excision repair, UV/ionizing radiation responses, and regulation of protein phosphorylation, indicating a coherent role in DNA damage signaling and repair across cell cycle contexts.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033314","count":1},{"id":"GO:0044778","count":1},{"id":"GO:0071479","count":1},{"id":"GO:0006468","count":1},{"id":"GO:0006289","count":1}]},{"hash":"316607112692328094","title":"Unknown","description":"The top GO terms span ubiquitination, mRNA processing, cell migration, calcium signaling, and various membrane/contractile processes, with a few very specific terms that don\u2019t clearly connect. This mix suggests no single coherent function characterizes the entire cluster, so a concise, representative label isn\u2019t evident.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0002268","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0071901","count":3}]},{"hash":"1286026004415677469","title":"Cholesterol handling with innate immune signaling","description":"The cluster\u2019s top GO terms are dominated by cholesterol transport, cholesterol metabolism, cholesterol efflux, and lipid storage, pointing to cholesterol homeostasis as the core theme. Additional terms for toll-like receptor 4 signaling and cellular response to lipopolysaccharide suggest an immune signaling component, with necroptotic process linking to inflammatory cell death. A neuromuscular balance term appears but seems secondary to the lipid/immune theme. Overall, cholesterol metabolism with an accompanying innate immune response signal best explains the cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032367","count":2},{"id":"GO:0008203","count":1},{"id":"GO:0070266","count":1},{"id":"GO:0033344","count":1},{"id":"GO:0071222","count":1}]},{"hash":"696880997423663655","title":"DNA Replication and Cell Cycle","description":"The top terms cluster around DNA replication and mitotic cell cycle processes, including DNA replication, initiation, primer synthesis, and telomere maintenance via recombination, which together suggest a core theme of genome duplication and cell division. Some terms (e.g., responses to superoxide, nitrogen fixation, and 3-methylcholanthrene) appear unrelated and indicate heterogeneity or broader roles of these proteins, but the dominant signal is replication and cell-cycle related.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:1902896","count":2},{"id":"GO:0000722","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0006269","count":1}]},{"hash":"1962434773655645400","title":"Unknown","description":"The GO terms are highly diverse (GPCR signaling, cell migration, regulation of kinase activity, calcium transport, pinocytosis, membrane depolarization in cardiac cells, and telomere maintenance/localization), with little evident unifying biological process or molecular function across all proteins. Because no single, representative theme emerges, a concise and confident cluster label cannot be assigned.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0002268","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0071901","count":3},{"id":"GO:0098703","count":3}]},{"hash":"1571026468652409451","title":"Renal morphogenesis with innate immune signaling","description":"The top GO terms blend kidney developmental processes (metanephric proximal/distal tubule and mesonephric duct development) with vascular/immune activities (lymph vessel morphogenesis, leukocyte tethering/rolling, stimulatory C-type lectin receptor signaling, and fungal-origin response), suggesting a cluster of proteins involved in nephrogenesis that also engages innate immune and vascular signaling pathways.","confidence":"Medium","size":22,"edges":172,"triangles":747,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":8},{"id":"GO:0036303","count":7},{"id":"GO:0072287","count":7},{"id":"GO:0010572","count":7},{"id":"GO:0072218","count":7}]},{"hash":"1130786749678119175","title":"Mechanosensory signaling and potassium homeostasis","description":"Top GO terms cluster around nociception and mechanosensory perception (pain and touch) together with potassium ion transport and membrane-potential regulation (export/import, transmembrane transport, resting potential, repolarization). This combination suggests a core role in sensory signaling in neurons and in maintaining ionic gradients needed for action potentials. The multicellular development term is broader and likely ancillary to the primary mechanosensory/ionic theme.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0007275","count":9},{"id":"GO:0030322","count":8},{"id":"GO:0030007","count":8},{"id":"GO:0050976","count":7}]},{"hash":"1537011063433044686","title":"Neurotransmitter metabolism and redox homeostasis","description":"The top GO terms cluster around monoamine turnover (dopamine catabolic process; negative regulation of serotonin secretion; neurotransmitter catabolic process) and redox balance (oxidation-reduction process; cell redox homeostasis). While there are also immune- or differentiation-related terms, the dominant theme is the interplay between neurotransmitter metabolism and cellular redox regulation, justifying this label.","confidence":"Medium","size":22,"edges":14,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006412","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0042420","count":3},{"id":"GO:0034720","count":3}]},{"hash":"1383264944915567480","title":"Neuronal signaling and ion transport","description":"These proteins are enriched for GO terms related to ion transport across membranes (K+, Na+, Ca2+), membrane depolarization, synaptic transmission (excitatory postsynaptic potential, GABA signaling), sensory perception (sound), and related behaviors (locomotion, conditioned taste aversion), suggesting neural excitability and signal processing.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":12},{"id":"GO:0060079","count":12},{"id":"GO:0035725","count":12},{"id":"GO:0007626","count":12},{"id":"GO:0001661","count":11}]},{"hash":"2199962852260470500","title":"Cardiovascular GPCR signaling and immune regulation","description":"The GO terms cluster around neurohumoral control of cardiovascular function (renin-angiotensin\u2013regulated blood pressure, GPCR signaling including dopamine receptor pathways, acetylcholine metabolism, prostaglandin response, and cardiac smooth muscle differentiation) as well as immune modulation (immune response, IL-1 beta regulation, cytolysis), suggesting a cohesive theme of cardiovascular signaling intertwined with immune regulation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":20},{"id":"GO:0007195","count":20},{"id":"GO:0060408","count":20},{"id":"GO:0007497","count":20},{"id":"GO:0006955","count":20}]},{"hash":"1863175099670375511","title":"Ion Transport and Osmotic Stress Response","description":"The cluster is dominated by GO terms related to ion transport across membranes (sodium import, potassium export) and intracellular potassium homeostasis, pointing to a core function in maintaining ionic balance. Several terms also reference cellular stress responses, including osmotic-stress\u2013induced apoptotic signaling and stress-related cardiac hypertrophy, suggesting these proteins participate in signaling pathways that link ion homeostasis to stress responses. Additional terms on GPCR signaling and immune signaling appear as broader, secondary roles. Overall, the unifying theme is ion transport/homeostasis intertwined with osmotic and stress signaling.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098719","count":6},{"id":"GO:0097623","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0030007","count":6},{"id":"GO:0007275","count":6}]},{"hash":"2056620179060010761","title":"Neural and inner ear development","description":"The top GO terms cluster around vertebrate nervous system and sensory organ development, especially brain and inner ear development, inner ear auditory receptor differentiation, and peripheral myelination, with additional signals of general somite and odontogenesis processes. This suggests a cohesive theme of neural and sensory tissue formation during development, making the label representative. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0048839","count":5},{"id":"GO:0007568","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0050901","count":4}]},{"hash":"81486037457189295","title":"Xenobiotic, vitamin, sugar, and ion transporters","description":"The Top Terms show transmembrane transport across diverse substrates (xenobiotics, vitamins, sugars like galactose, fructose, arabinose, and potassium ions) along with osmotic/stress responses, indicating a cluster of membrane transport proteins with broad substrate specificity.","confidence":"High","size":22,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":22},{"id":"GO:0035461","count":22},{"id":"GO:0071805","count":19},{"id":"GO:0042908","count":19},{"id":"GO:0042891","count":17}]},{"hash":"1161666763989997514","title":"Developmental cell adhesion and mechanotransduction","description":"This cluster centers on processes involving cell adhesion (integrin signaling and substrate adhesion-dependent spreading) and development (mammary gland development, embryonic cranial skeleton morphogenesis), with support from cellular responses to mechanical stimuli. While a few terms relate to innate immunity or pain, the dominant signals point to adhesion-mediated signaling guiding morphogenesis and tissue development.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0071372","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0030879","count":2}]},{"hash":"392334931111186919","title":"Mitochondrial respiration and Fe-S cluster biogenesis","description":"The top terms cluster around mitochondrial energy production\u2014mitochondrial electron transport, proton transmembrane transport, and aerobic respiration\u2014along with iron-sulfur (Fe-S) cluster assembly/maturation and protein import into the mitochondrial matrix. This points to a cohesive set of proteins involved in mitochondrial respiration and Fe-S cofactor biogenesis, with a few outliers (e.g., nitrogen fixation, nucleotide metabolism) that may reflect annotation noise. Confidence: High.","confidence":"","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":3},{"id":"GO:0016226","count":3},{"id":"GO:1902600","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0097428","count":2}]},{"hash":"594877399232084756","title":"Ribosome biogenesis and translation","description":"Mostly translation- and ribosome-related, with terms for translation, mRNA export, rRNA maturation, and initiation/reinitiation, indicating a cluster of ribosome biogenesis and protein synthesis machinery. A couple of peripheral terms (DNA repair, innate immune response) are also present.","confidence":"High","size":22,"edges":17,"triangles":16,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006406","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0006281","count":2},{"id":"GO:1901407","count":2}]},{"hash":"928744493867201814","title":"ER-Golgi trafficking and Wnt secretion","description":"The top GO terms cluster around the secretory pathway: COPI coating of Golgi vesicles, ER lumen protein retention, and positive regulation of ER exit, all pointing to protein trafficking from the ER through the Golgi to secretion. The inclusion of Wnt protein secretion, along with development-related terms (axis specification, placenta development) and related processes (egg-laying behavior, amyloid-beta regulation via secretory routes) supports a cohesive theme of protein trafficking and secretory signaling. Some terms like ozone response or triglyceride metabolism are less central, but the dominant signal is ER-Golgi transport and Wnt-mediated secretion.","confidence":"High","size":22,"edges":15,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0010193","count":3},{"id":"GO:0006641","count":3},{"id":"GO:0048205","count":3},{"id":"GO:0006621","count":3},{"id":"GO:0001893","count":3}]},{"hash":"1083656186416197025","title":"Developmental ECM remodeling","description":"Top GO terms point to collagen fibril organization, negative regulation of angiogenesis, and platelet aggregation, indicating extracellular matrix remodeling and vascular development. Additional terms cover actin nucleation and cell movement, ribosome biogenesis, and general development. Overall, the proteins appear to be involved in structural organization and developmental processes with cytoskeletal dynamics, rather than a single cohesive pathway. If forced to pick a label, Developmental ECM remodeling captures the recurring theme of ECM organization and morphogenesis reflected by the terms, with supporting roles for cytoskeletal changes and growth-related processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0070527","count":3},{"id":"GO:0050830","count":2},{"id":"GO:2000601","count":2}]},{"hash":"629916362899631359","title":"Neuronal Actin Remodeling and Insulin Signaling","description":"This cluster shows strong representation of actin cytoskeleton organization and actin-related processes (crosslinking, polymerization, filament bundling, ruffle assembly) along with neuronal development signals (dendrite development, excitatory postsynaptic potential) and regulation of insulin signaling, suggesting a theme of actin-driven membrane remodeling in neurons modulated by insulin.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051764","count":5},{"id":"GO:0030838","count":4},{"id":"GO:0046626","count":4},{"id":"GO:0016358","count":4},{"id":"GO:0030036","count":4}]},{"hash":"1037079927412417760","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039702","count":2}]},{"hash":"1383066595970140483","title":"Membrane Solute Transporters","description":"This cluster is dominated by transmembrane transport functions across multiple substrates (ions, sugars, xenobiotics, phosphate, nitrates) and includes a term on vesicular neurotransmitter loading, indicating a cohesive theme of diverse membrane transporter proteins. ","confidence":"High","size":22,"edges":49,"triangles":47,"max_degree":15,"top_function":"protein folding","top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0015757","count":4},{"id":"GO:0015751","count":4},{"id":"GO:0015739","count":4},{"id":"GO:0015706","count":4}]},{"hash":"636777783307436301","title":"Multitissue Development and Morphogenesis","description":"The top GO terms cluster around development and tissue morphogenesis across multiple organs\u2014nervous system and neuron development, synapse organization, skeletal and lens differentiation, endothelial morphogenesis, cell adhesion, and multicellular development. This suggests a general developmental/differentiation theme rather than a specialized pathway, so Multitissue Development and Morphogenesis is a representative and concise label.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0031175","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0050808","count":3}]},{"hash":"813336976947669885","title":"Immune Activation and Inflammation","description":"Based on GO terms enriched in this cluster, there is a clear emphasis on immune function: adaptive immune response, antigen processing and presentation via MHC class I, cell signaling related to immune interactions, and leukotriene biosynthesis. Additional terms for angiogenesis and multicellular development suggest tissue remodeling processes often linked to immune responses. The mix points to a cluster of proteins involved in host defense and inflammatory signaling, with possible growth/angiogenic context. Therefore the label Immune Activation and Inflammation captures the core theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0019885","count":2},{"id":"GO:0030154","count":2},{"id":"GO:0019370","count":2},{"id":"GO:0002005","count":2}]},{"hash":"504324922163060964","title":"Tissue Development and Morphogenesis","description":"This cluster shows recurring terms tied to shaping tissues and barriers, including tendon development, skin morphogenesis, cuticle development, and podocyte development, suggesting a shared role in tissue formation. Other terms related to lipoprotein clearance, aldosterone secretion, and complement activation appear less central, likely incidental associations.","confidence":"Medium","size":22,"edges":25,"triangles":24,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045715","count":1},{"id":"GO:0035989","count":1},{"id":"GO:2000860","count":1},{"id":"GO:0034381","count":1},{"id":"GO:2000478","count":1}]},{"hash":"2086394344918810288","title":"Neuronal morphogenesis and vesicle trafficking","description":"This cluster is enriched for neuronal development signals (brain development, axon guidance, dendritic spine morphogenesis) and intracellular trafficking processes (Golgi organization, ER-to-Golgi transport, Cvt pathway), suggesting proteins coordinating neuronal morphogenesis with vesicle trafficking.","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0032258","count":5},{"id":"GO:0060999","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0097178","count":5}]},{"hash":"633769418004515389","title":"Synapse Organization and Vesicle Trafficking","description":"The cluster is dominated by terms related to synapse architecture and vesicle dynamics: postsynaptic density clustering, regulation of receptor recycling, cytoskeletal organization at the active zone, and positive regulation of synaptic vesicle clustering. Together they point to synapse organization and vesicle trafficking. Some non-neuronal terms appear in the list, suggesting annotation noise, but the neuronal terms strongly define the cluster\u2019s core function.","confidence":"High","size":22,"edges":227,"triangles":1463,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0090122","count":7},{"id":"GO:0048444","count":7},{"id":"GO:2000331","count":7},{"id":"GO:0030245","count":7}]},{"hash":"505084391256996777","title":"Mitochondrial Transport and Energy Metabolism","description":"The cluster is dominated by GO terms related to mitochondrial function, including regulation of mitochondrial membrane permeability and multiple transmembrane transport processes (ATP, ADP, NAD, NAD transmembrane transport), as well as thermogenesis and mitochondrial protein localization/dynamics. The presence of diverse transport and energy-related terms (heme, pyridoxal phosphate, NAD, ADP) alongside mitochondrial context strongly suggests a cohesive theme around mitochondrial transport and energy metabolism.","confidence":"High","size":22,"edges":18,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046902","count":22},{"id":"GO:1990544","count":22},{"id":"GO:1990845","count":22},{"id":"GO:0015886","count":22},{"id":"GO:0034198","count":22}]},{"hash":"1178346946486175229","title":"Cell adhesion and migration signaling","description":"The top GO terms cluster around cell adhesion, lamellipodium assembly, Rac/Rho signaling, and chemotaxis (neutrophil chemotaxis, substrate adhesion-dependent spreading), with related vascular permeability and GPCR/cAMP signaling, indicating a cohesive theme of cytoskeletal remodeling and cell movement driven by adhesion signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0007224","count":2},{"id":"GO:0086023","count":1},{"id":"GO:0030032","count":1}]},{"hash":"1119424444310805084","title":"Coagulation and Innate Immune Defense","description":"This cluster centers on processes related to blood coagulation, classical complement activation, leukocyte migration, and defense against bacteria, pointing to a coordinated innate immune and hemostatic module. Additional terms like transcriptional regulation and developmental processes appear as less central or context-specific nearby signals, but do not override the dominant coagulation/immune theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0003050","count":3}]},{"hash":"1607165399529320044","title":"Neural signaling and sensory perception","description":"The enrichment centers on sensory and neural communication: pain perception, retina development and phototransduction, neuropeptide signaling, locomotory behavior, and responses to psychostimulants like amphetamine, all pointing to neuronal signaling and sensory processing. Calcium release regulation and GPCR-linked signaling further support neuronal signaling cascades. Some terms (thermogenesis, TNF regulation) are peripheral, but they do not override the dominant neural/sensory theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0060041","count":4},{"id":"GO:0007218","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0001975","count":4}]},{"hash":"721654224922353752","title":"Embryogenesis and placental morphogenesis","description":"Most top GO terms point to embryonic development and tissue morphogenesis across multiple organs (trophoblast giant cell differentiation, placenta development, left/right patterning, cartilage morphogenesis, pancreatic development). This pattern suggests the cluster comprises proteins involved in developmental regulation and organogenesis, with some general RNA processing roles that support gene regulation during development. Therefore, the label reflects the dominant theme of developmental differentiation and morphogenesis.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0060536","count":19},{"id":"GO:0035270","count":19},{"id":"GO:0060972","count":19}]},{"hash":"1562638365799500968","title":"Viral integration and release","description":"The top GO terms cluster around viral life cycle steps: DNA integration, proviral latency establishment, and viral release, indicating a theme of virus\u2013host interactions. Some other terms (neuronal/behavioral and development terms) seem less central or potentially noisy annotations, but the dominant signals point to viral integration and release. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0019076","count":3},{"id":"GO:0008344","count":2}]},{"hash":"77718026465185867","title":"Immune-signaling deubiquitinases","description":"GO terms point to multiple types of protein deubiquitination (K6/K63/K27/K48) and negative regulation of key immune pathways (NF-\u03baB, CD40, NOD1) and cytokine production, suggesting a cluster of DUBs that dampen immune signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044313","count":1},{"id":"GO:0070536","count":1},{"id":"GO:1990167","count":1},{"id":"GO:2000352","count":1},{"id":"GO:2000349","count":1}]},{"hash":"2252544659254633811","title":"Platelet-Immune Activation and Coagulation","description":"The terms cluster around immune processes (immune response, dendritic cell and monocyte chemotaxis) and platelet/coagulation pathways (platelet activation, blood coagulation, vasoconstriction), with associated signaling (ERK cascade, calcium release). This suggests a cohesive module where platelets interface with the immune system to regulate coagulation and vascular responses, supported by related signaling and lipid-associated processes. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006955","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0045907","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0007596","count":2}]},{"hash":"1802562179905085737","title":"TLR/NF-\u03baB\u2013driven innate inflammation","description":"The cluster is dominated by GO terms for innate immune response, TLR4 signaling, dsRNA response, and NF-\u03baB\u2013mediated inflammation, with broader defenses against Gram-positive bacteria and viruses and cytokine production, indicating a cohesive innate immune activation program.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043123","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0050830","count":4},{"id":"GO:0034142","count":4},{"id":"GO:0043330","count":4}]},{"hash":"1651682958181017637","title":"cGMP/cAMP Signaling in Light Sensing","description":"The terms cluster around cyclic nucleotide signaling (cGMP and cAMP), including their biosynthesis and receptor-mediated pathways (receptor guanylyl cyclase, adenylate cyclase activation), plus blue light signaling and general intracellular signal transduction. The inclusion of oocyte maturation regulation via cGMP adds a coherent link to the broader role of these second messengers in sensory and developmental signaling. This suggests proteins functioning in light-sensing and related signaling pathways driven by cyclic nucleotides.","confidence":"Medium","size":21,"edges":4,"triangles":1,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0070483","count":18},{"id":"GO:0035556","count":18},{"id":"GO:0009785","count":18},{"id":"GO:0006182","count":18},{"id":"GO:1900194","count":18}]},{"hash":"1616363736210122638","title":"Neuro-Muscular and Cardiac Development with Cell Cycle","description":"The cluster shows a strong representation of developmental processes across nervous system, muscle, and heart (axonogenesis, myoblast fusion, heart development, visual perception) along with cell cycle regulation (G2/M transition, mitotic cell cycle) and apoptosis control. This suggests a cohesive theme of coordinated tissue development and proliferative signaling, with an outlier term for abscisic acid signaling that may reflect cross-species annotation noise. Overall, the label captures the dominant developmental and proliferative functions.","confidence":"Medium","size":21,"edges":171,"triangles":795,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007409","count":21},{"id":"GO:0009738","count":21},{"id":"GO:0043065","count":21},{"id":"GO:0010800","count":21},{"id":"GO:0007520","count":21}]},{"hash":"826850503345203112","title":"Mitotic spindle assembly and cytoskeleton organization","description":"The cluster is dominated by GO terms related to mitosis and spindle/cytoskeleton dynamics (metaphase chromosome alignment, spindle pole separation, spindle midzone assembly, microtubule polarity, cytokinesis). These indicate a cohesive function in cell division machinery and cytoskeletal organization, with a few ancillary terms that are less central to this core theme. ","confidence":"High","size":21,"edges":129,"triangles":437,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0007080","count":21},{"id":"GO:0098971","count":21},{"id":"GO:0000073","count":21},{"id":"GO:0000915","count":21},{"id":"GO:0030951","count":21}]},{"hash":"303048338552117173","title":"MAPK and Immune Signaling Regulators","description":"This cluster is dominated by GO terms that regulate MAPK/ERK signaling (e.g., negative regulation of ERK cascade) and immune signaling pathways (NK cell cytotoxicity, T cell receptor signaling, TLR3 signaling), with some neural development terms (cerebellar cortex formation, axon regeneration) also present. The common thread appears to be modulators of intracellular signaling, particularly in immune contexts, rather than a single physiological process, so a label emphasizing signaling regulation is most representative.","confidence":"Medium","size":21,"edges":114,"triangles":274,"max_degree":17,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0070373","count":12},{"id":"GO:0042267","count":12},{"id":"GO:0000200","count":12},{"id":"GO:0050860","count":12},{"id":"GO:0048679","count":10}]},{"hash":"1253828078397729385","title":"Embryonic Development and Organogenesis","description":"The cluster contains multiple development-related terms (embryonic cranial skeleton morphogenesis, heart development, Schwann cell development, myoblast fusion, multicellular organism development) indicating a shared theme of tissue formation and organismal development. It also includes cell-cycle terms (DNA replication, G2/M transition), suggesting proliferation accompanies development. The abscisic acid-activated signaling term is likely annotation noise or cross-species misannotation and not central to the cluster. Overall, the label captures a developmental/organogenesis focus that ties the proteins together beyond a single tissue type.","confidence":"High","size":21,"edges":15,"triangles":3,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":12},{"id":"GO:0006260","count":12},{"id":"GO:0010800","count":11},{"id":"GO:0007520","count":11},{"id":"GO:0009738","count":11}]},{"hash":"1166718417718024134","title":"Neurotransmission and sensory signaling","description":"The cluster centers on neural signaling and sensory processing: terms for pain perception, vision/opsin signaling, response to amphetamine, and cellular responses to temperature, plus calcium/phosphorylation-driven signaling that modulates cardiac and vascular functions. This combination suggests a core theme of neurotransmission with sensory and autonomic regulation.","confidence":"High","size":21,"edges":37,"triangles":51,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":4},{"id":"GO:0001975","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0006468","count":3}]},{"hash":"1337002154058683062","title":"Cardiovascular GPCR signaling","description":"Top GO terms point to GPCR signaling and blood pressure regulation (adenylate cyclase-activating/inhibiting pathways, renin-angiotensin regulation) with involvement of prostaglandin signaling and acetylcholine metabolism, suggesting a cohesive set of proteins that modulate vascular tone via GPCR pathways. While electron transport and immune-related terms appear, the dominant theme is GPCR-mediated control of cardiovascular function, especially blood pressure. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":15},{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0001991","count":14},{"id":"GO:0007195","count":14}]},{"hash":"874677394918568186","title":"GPCR-Mediated Neuroendocrine Signaling","description":"The top GO terms cluster around G protein-coupled receptor signaling and related neuroendocrine processes: dopamine and acetylcholine signaling, prostaglandin responses, regulation of GPCR signaling, and RAAS-related pathways, along with diet-induced thermogenesis and temperature/pain responses. This suggests a cohesive theme of GPCR-driven signaling coordinating metabolic, vascular, and immune functions. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0071502","count":19},{"id":"GO:0001991","count":18},{"id":"GO:0007195","count":18}]},{"hash":"661821841775278594","title":"AGP glycosylation and seed mucilage biosynthesis","description":"The top GO terms point to arabinogalactan protein metabolism, mucilage biosynthetic processes in seed coat development, and related glycosylation pathways (Lewis a epitope, O-linked glycosylation). This indicates a cluster of secreted, glycosylated cell-wall proteins (AGPs) involved in seed mucilage production and AGP maturation via the secretory pathway (ER retention, polarity maintenance). Some related terms about epithelial polarity or infection structures may be incidental, but the core signal is AGP glycosylation and seed mucilage biosynthesis.","confidence":"Medium","size":21,"edges":38,"triangles":10,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":5},{"id":"GO:0006621","count":3},{"id":"GO:0080147","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0048354","count":3}]},{"hash":"1943796918937140618","title":"Steroid and eicosanoid biosynthesis","description":"The top GO terms point to biosynthetic pathways for lipid-derived hormones and mediators\u2014prostaglandins, aldosterone, cortisol, progesterone, and retinoic acid\u2014with involvement of epoxygenase P450 enzymes. This suggests the proteins in the cluster specialize in lipid/hormone biosynthesis and metabolism, with a possible ancillary role suggested by a few peripheral terms. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":19},{"id":"GO:0019383","count":18},{"id":"GO:2001037","count":18},{"id":"GO:0042904","count":18},{"id":"GO:0032342","count":18}]},{"hash":"1002808378340259356","title":"TNF/NF-kB inflammatory response and DNA damage signaling","description":"The cluster is driven by terms pointing to innate immune activation (cellular response to lipopolysaccharide, TNF-mediated signaling, regulation of NF-kappaB) and stress-induced apoptosis (intrinsic apoptotic signaling in response to DNA damage by p53), suggesting a module centered on inflammation and DNA damage responses. Some terms (mRNA splicing, cholesterol homeostasis) reflect general cellular maintenance rather than core function, but the dominant theme is inflammatory signaling tied to stress responses.","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0033209","count":3},{"id":"GO:0042347","count":3},{"id":"GO:0034051","count":3},{"id":"GO:0042771","count":3}]},{"hash":"106216008599793446","title":"Ribosome biogenesis and translation","description":"The top GO terms are centered on translation and ribosome biogenesis, including maturation and export of ribosomal subunits and rRNA processing, indicating proteins involved in ribosome assembly and protein synthesis.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0042254","count":10},{"id":"GO:0000462","count":4},{"id":"GO:0042273","count":3},{"id":"GO:0000055","count":3}]},{"hash":"873121529079501186","title":"Developmental Organ Morphogenesis and Differentiation","description":"Top GO terms are dominated by developmental and morphogenesis processes across organs (heart outflow tract, skeletal system, lens), with supporting signals for germ plasm localization and cilium assembly, indicating a focus on cellular differentiation and organ patterning during development. While there are some ubiquitin-proteasome and host-entry terms, the strongest cohesion is developmental organization and tissue morphogenesis, suggesting the cluster comprises proteins involved in embryonic development and differentiation of multiple organs.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0003151","count":3},{"id":"GO:0045451","count":2},{"id":"GO:0070306","count":2}]},{"hash":"2045938340095342027","title":"B cell activation and homeostasis","description":"Top GO terms indicate a cluster enriched for B cell\u2013related processes: B cell receptor signaling, positive regulation of B cell proliferation, and B cell homeostasis, suggesting activation and maintenance of B cell function. There are additional immune signaling terms (gamma-d delta T cell differentiation, T cell homeostasis) and actin cytoskeleton organization that can accompany immune cell signaling, while a few developmental terms appear at low frequency and do not define the core function. Overall, the prominent B cell\u2013related terms support labeling this cluster as B cell activation and homeostasis.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045588","count":2},{"id":"GO:0001782","count":2},{"id":"GO:0030890","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0030866","count":2}]},{"hash":"87934172914921724","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms cluster around embryogenesis and organogenesis, including trophoblast giant cell differentiation, placental development, left-right patterning, cartilage morphogenesis, and endocrine system development, plus epithelial-to-mesenchymal transition in heart formation. This points to a group of proteins involved in developmental differentiation and morphogenesis across tissues, with some involvement in general gene regulation (RNA processing and transcription). The lack of edges suggests these proteins share the general developmental theme rather than a single specific pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":18},{"id":"GO:0060806","count":17},{"id":"GO:0060536","count":17},{"id":"GO:0035270","count":17},{"id":"GO:0060972","count":17}]},{"hash":"1184509700550896686","title":"Vesicle trafficking and actin dynamics","description":"This cluster centers on vesicle transport and secretory pathways: endosome to melanosome transport, exosomal secretion, and synaptic vesicle exocytosis, plus regulation of actin filament polymerization. The presence of cytoplasmic-vacuolar targeting and related trafficking terms reinforces a cohesive vesicle- and cytoskeleton-focused theme, with some developmental terms likely reflecting downstream effects. ","confidence":"High","size":21,"edges":65,"triangles":69,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035646","count":17},{"id":"GO:1900026","count":17},{"id":"GO:0033144","count":17},{"id":"GO:0090103","count":16},{"id":"GO:0030838","count":16}]},{"hash":"1736371181418525236","title":"Splicing regulation and translation initiation","description":"The terms cluster around spliceosome-mediated alternative mRNA splicing and various facets of initiating translation, including preinitiation complex formation and IRES-dependent initiation, with additional notes on mRNA tail regulation and small-subunit processome assembly. This points to a cohesive post-transcriptional control module linking RNA processing to translation start. ","confidence":"High","size":21,"edges":7,"triangles":2,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":5},{"id":"GO:0000380","count":5},{"id":"GO:0060211","count":4},{"id":"GO:0006446","count":4},{"id":"GO:1901407","count":4}]},{"hash":"1994512937231235731","title":"Wnt-driven embryonic development and adhesion","description":"The top GO terms center on embryonic development (in utero, ventral spinal cord) and regulation of canonical Wnt signaling, with supporting evidence from heterophilic cell\u2013cell adhesion, suggesting a cluster of proteins involved in developmental signaling and tissue organization. Other terms like cholesterol response or membrane attack complex regulation are peripheral to this core theme. ","confidence":"Medium","size":21,"edges":49,"triangles":55,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0071397","count":4},{"id":"GO:0007157","count":3},{"id":"GO:0060828","count":3},{"id":"GO:0003050","count":3},{"id":"GO:1902960","count":3}]},{"hash":"1430963052517223038","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:0070102","count":2},{"id":"GO:0051044","count":2},{"id":"GO:0019985","count":1},{"id":"GO:0007098","count":1}]},{"hash":"581429409519986385","title":"Axon Guidance and Paranode Juxtaparanode Localization","description":"The top GO terms point to neuronal development and axon organization, including branchiomotor neuron axon guidance, neural crest migration, and sympathetic neuron projection extension, as well as protein localization to paranode and juxtaparanode regions of myelinated axons. Additional terms about collagen fibril organization and cell adhesion support extracellular matrix interactions relevant to neurite outgrowth and nerve wiring; a few terms about complement activation appear incidental. Overall, the cluster seems to reflect axon pathfinding and localization to specialized axonal domains, justifying this label.","confidence":"High","size":21,"edges":42,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045162","count":3},{"id":"GO:0002175","count":3},{"id":"GO:0006958","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0030199","count":2}]},{"hash":"1620831171661420481","title":"Neuronal signaling and ion transport proteins","description":"Most prominent terms are calcium ion transmembrane transport and excitatory postsynaptic potential, indicating neural signaling; other terms show regulatory and transport roles, implying a mixed but loosely connected set of signaling/transport proteins.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070588","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0006824","count":1},{"id":"GO:0009235","count":1},{"id":"GO:0015889","count":1}]},{"hash":"882375304834551556","title":"Ectodermal and neural tissue development","description":"GO terms point to development and maturation of ectoderm-derived structures and neural tissues (hair cycle, keratinization, epithelial maturation; cochlea morphogenesis; palate roof development; neural differentiation in brain and spinal cord; neurohypophysis development). The common thread is embryonic morphogenesis across multiple tissues rather than a specific pathway.","confidence":"Medium","size":21,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":2},{"id":"GO:0031424","count":2},{"id":"GO:0021526","count":1},{"id":"GO:0002070","count":1},{"id":"GO:0030917","count":1}]},{"hash":"1961866872170907292","title":"Membrane protein biogenesis and immune response","description":"The cluster features GO terms tied to membrane-associated processes (GPI anchor biosynthesis; endosome to plasma membrane transport; synaptic vesicle clustering) alongside immune-related responses (cellular oxidant detoxification, response to interferon-beta, response to biotic stimulus, host-mediated suppression of symbiont invasion). A few bone-related terms appear but the prominent themes center on membrane protein processing/trafficking and immune signaling, supporting this label.","confidence":"Medium","size":21,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0006506","count":2},{"id":"GO:0030282","count":1},{"id":"GO:0097091","count":1},{"id":"GO:0060349","count":1}]},{"hash":"1454063352927859766","title":"Integrin-Mediated Adhesion and Signaling","description":"The dominant terms are calcium-independent cell-matrix adhesion, heterotypic cell-cell adhesion, cellular extravasation, and the integrin-mediated signaling pathway, pointing to a cohesive theme of adhesion and downstream signaling governing cell movement and tissue organization. Some terms like endodermal differentiation and proteasome assembly appear less directly connected, likely reflecting broader, cross-species annotations, but the core cluster clearly centers on adhesion-related processes. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0007161","count":6},{"id":"GO:0034113","count":6},{"id":"GO:0045123","count":6},{"id":"GO:0007229","count":6},{"id":"GO:0035987","count":6}]},{"hash":"460158536076754811","title":"Steroid and Lipid Biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for steroids (estrogen, glucocorticoids), sphingolipids, fatty acids, retinoic acid, melanin, and other lipid-derived metabolites, suggesting proteins that participate in lipid- and steroid-biosynthesis pathways (with some pigment-related biosynthesis as well). Despite one obsolete term, the shared theme is assembly of lipid- and steroid-based compounds. ","confidence":"High","size":21,"edges":146,"triangles":501,"max_degree":19,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0030148","count":11},{"id":"GO:0006703","count":11},{"id":"GO:0006710","count":11},{"id":"GO:0042438","count":11}]},{"hash":"742724386023723797","title":"Myogenesis and Tissue Remodeling","description":"This cluster centers on muscle development and tissue remodeling. The top GO terms include myoblast differentiation, tissue remodeling, extracellular matrix disassembly, and morphogenesis-related processes such as apical constriction and growth-factor responses, pointing to roles in muscle cell formation and ECM remodeling during tissue morphogenesis, with additional ties to cell migration and inflammatory regulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045445","count":2},{"id":"GO:0048771","count":2},{"id":"GO:0090201","count":2},{"id":"GO:0003383","count":2},{"id":"GO:0051919","count":2}]},{"hash":"1976946002660145434","title":"Apoptotic cell clearance and angiogenesis regulation","description":"The Top Terms show apoptotic cell recognition and engulfment (GO:0043654, GO:0043652) together with modulation of vascular signaling, including VEGF pathway regulation (GO:1900748; GO:0016525, GO:2001027). Although oxidative stress and Notch signaling terms appear, the recurring themes are clearance of dying cells and control of angiogenesis, suggesting a cluster of proteins involved in tissue remodeling and immune clearance during development or stress. The edges are zero, indicating a dispersed set of related functions rather than a single pathway. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0043654","count":2},{"id":"GO:0045746","count":2}]},{"hash":"2034397475714817307","title":"Translation and tRNA modification","description":"The top GO terms are centered on protein synthesis and tRNA biology (translation, valyl-tRNA aminoacylation, tRNA wobble uridine modification, and regulation of translational fidelity), with supporting signals related to growth and trafficking (cell division, Golgi localization). This makes a concise, representative label Translation and tRNA modification.","confidence":"High","size":21,"edges":156,"triangles":622,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0006438","count":2},{"id":"GO:0006450","count":2},{"id":"GO:0009060","count":2}]},{"hash":"1120295911859522133","title":"Bone formation and connective tissue remodeling","description":"The terms cluster around bone biology and extracellular matrix processes: regulation of BMP signaling and osteoblast differentiation, collagen fibril organization, skeletal muscle satellite cell maintenance in regeneration, and fibroblast proliferation; together these point to skeletal tissue development and ECM remodeling, with some ancillary apoptosis/immune signals. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0045880","count":2},{"id":"GO:0045668","count":2},{"id":"GO:2000270","count":2}]},{"hash":"772799565592004858","title":"Unknown","description":"The top GO terms cover ubiquitin-dependent protein degradation, immune cell differentiation, cell migration, kinase activity regulation, calcium transport, endocytosis, membrane depolarization, and telomere/chromosome localization. These functions are diverse and do not converge on a single clear biological theme for the cluster, so there isn\u2019t a cohesive label beyond Unknown.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0002268","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0071901","count":5},{"id":"GO:0098703","count":5}]},{"hash":"1104933753628971670","title":"Axon Guidance and Paranodal Localization","description":"The terms cluster around neuron development, especially axon guidance and the assembly/localization of paranodal/juxtaparanodal regions, with references to branchiomotor/trigeminal neuron guidance, nerve organization, and semaphorin-plexin signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":8},{"id":"GO:0002175","count":8},{"id":"GO:0021785","count":8},{"id":"GO:0030913","count":8},{"id":"GO:0021637","count":8}]},{"hash":"1198854720141797448","title":"Localization and trafficking","description":"The terms cluster around transport and localization processes: ER-to-Golgi vesicle trafficking, mRNA localization in oocytes (bicoid, oskar), regulation of receptor localization at synapses, and vesicle transport related to polarity and axis specification. Peripheral terms like chloroplast fission and phycocyanobilin linkage are less central, but the dominant theme is subcellular localization and trafficking of molecules. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":1},{"id":"GO:0045450","count":1},{"id":"GO:0030722","count":1},{"id":"GO:2000311","count":1},{"id":"GO:1902684","count":1}]},{"hash":"821662245191201613","title":"ER Protein Folding and UPR","description":"Top terms cluster around endoplasmic reticulum protein folding, unfolded protein response, ERAD, and chaperone-related refolding, indicating a coherent ER quality-control and stress-response program; additional links to redox homeostasis and translation regulation under ER stress (with some plant-specific signaling cues).","confidence":"High","size":20,"edges":22,"triangles":17,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":10},{"id":"GO:0045454","count":10},{"id":"GO:0006986","count":10},{"id":"GO:0070389","count":9},{"id":"GO:0051301","count":9}]},{"hash":"2152661761006305967","title":"Unknown","description":"The terms span diverse, only loosely related themes\u2014development (forebrain, neural tube, cartilage), transcriptional regulation, stress responses (cadmium, ER stress), immune defense, and cell cycle\u2014without a single coherent function linking all proteins.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0071276","count":7},{"id":"GO:0030900","count":6},{"id":"GO:0001501","count":6},{"id":"GO:0001843","count":6}]},{"hash":"568065192269534266","title":"Steroid and lipid biosynthesis cluster","description":"The top GO terms show strong representation of steroid hormone biosynthesis (glucocorticoid, estrogen, testosterone) and very long-chain fatty acid biosynthesis, with additional related lipid/metabolite biosynthesis like poly-hydroxybutyrate and phylloquinone catabolism, plus some antibiotic biosynthetic/metabolic terms. This suggests a cohesive theme around production and processing of lipophilic metabolites, including steroid hormones and fatty acids, with broader secondary metabolic pathways also represented. Confidence: Medium","confidence":"","size":20,"edges":56,"triangles":47,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":16},{"id":"GO:0042619","count":14},{"id":"GO:0006704","count":13},{"id":"GO:0042761","count":13},{"id":"GO:0046677","count":13}]},{"hash":"1137022578159100027","title":"Sterol and Isoprenoid Biosynthesis","description":"The dominant GO terms point to pathways making isoprenoid lipids: monoterpene, geranyl diphosphate, farnesyl diphosphate biosynthesis, and cholesterol biosynthesis. These terms cluster around sterol and terpenoid production, with a few more general phosphorylation or transport terms that are less central. This supports labeling the cluster as related to sterol/isoprenoid biosynthesis.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006695","count":4},{"id":"GO:0046940","count":3},{"id":"GO:0046939","count":3},{"id":"GO:0016310","count":3},{"id":"GO:0006120","count":3}]},{"hash":"55075141372667848","title":"GPCR Signaling in Vascular and Neural Regulation","description":"The cluster is enriched for GO terms indicating GPCR-mediated signaling affecting vascular tone and blood pressure (vasoconstriction, renin-angiotensin regulation), dopaminergic and acetylcholine pathways, and neuroimmune/eicosanoid responses (dopamine receptor signaling, prostaglandin response). The recurrent theme is GPCR signaling modulating cardiovascular and neural functions, with some development/immune terms probably tied to broader signaling networks. ","confidence":"High","size":20,"edges":17,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045907","count":14},{"id":"GO:0001975","count":14},{"id":"GO:0008542","count":14},{"id":"GO:0001991","count":13},{"id":"GO:0007195","count":13}]},{"hash":"741770178847581425","title":"Multifunctional Signaling Pathway Network","description":"This cluster shows a mix of GO terms covering insulin signaling, T and B cell receptor signaling, integrin-mediated signaling, and various developmental differentiation processes (platelet formation, cerebellar cortex formation, Bergmann glial differentiation), plus apoptosis execution. The diversity of signaling contexts suggests proteins involved in a broad signaling network rather than a single cohesive pathway, so a general \u201cmultifunctional signaling\u201d label best fits.","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0030220","count":3},{"id":"GO:0021697","count":3},{"id":"GO:0050852","count":3}]},{"hash":"726518912300012425","title":"P450-driven steroid and retinoid metabolism","description":"The top GO terms cluster around steroid hormone metabolism (aldosterone, progesterone biosynthesis/metabolism), retinoid pathways (9-cis-retinoic acid biosynthesis), vitamin D response, prostaglandin biosynthesis, and epoxygenase P450 activity. Together these point to cytochrome P450\u2013mediated processing of steroids, retinoids, and related signaling molecules, with xenobiotic detox themes (camphor catabolic process, ozone response) that reinforce a P450-centric metabolic role. Thus this label captures the shared function of the cluster.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":11},{"id":"GO:0008585","count":9},{"id":"GO:0001516","count":9},{"id":"GO:0019383","count":8},{"id":"GO:2001037","count":8}]},{"hash":"1422781483109413239","title":"GPCR Signaling and Neuroendocrine Regulation","description":"The top GO terms cluster around G protein-coupled receptor signaling and its regulation (dopamine receptor signaling, regulation of GPCR signaling, acetylcholine metabolism, prostaglandin response) with vascular and organ-development links (renin-angiotensin\u2013related blood pressure regulation; smooth muscle and midgut development). While immune-related terms appear, the dominant theme is GPCR-mediated signaling and its influence on cardiovascular/gut development and neuroendocrine activity. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":15},{"id":"GO:0007195","count":15},{"id":"GO:0060408","count":15},{"id":"GO:0007497","count":15},{"id":"GO:0006955","count":15}]},{"hash":"656714147789605762","title":"Arabinogalactan Protein Glycosylation (AGP) Metabolism","description":"The top GO terms point to glycosylation processes centered on arabinogalactan proteins (AGPs) and related cell-wall/mucilage biosynthesis (AGP metabolic process; mucilage biosynthetic process; O-linked glycosylation via hydroxyproline; Lewis a epitope biosynthesis). AGPs are plant cell-surface glycoproteins involved in development processes such as root hair formation and seed coat mucilage production, which aligns with several plant-related terms in the list. Some terms come from other taxa, but the shared thread is AGP glycosylation and surface glycoprotein biosynthesis in plants.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":5},{"id":"GO:0006486","count":4},{"id":"GO:0010493","count":4},{"id":"GO:0080147","count":3},{"id":"GO:0001744","count":3}]},{"hash":"303371838988966893","title":"RNA metabolism and xenobiotic response","description":"The top terms cluster around RNA processing and stability (regulation of mRNA stability, RNA phosphodiester bond hydrolysis, transcription-related terms) along with stress-related processes (response to xenobiotic stimulus, redox homeostasis, signaling via phosphatidylinositol dephosphorylation). A single, kidney-specific term (positive regulation of renal water transport) is present but may reflect broader tissue-specific annotation. Overall, the cluster appears to link RNA metabolism with cellular defense and signaling responses, making this name a concise fit.","confidence":"Medium","size":20,"edges":64,"triangles":46,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:2001153","count":8},{"id":"GO:1903507","count":8},{"id":"GO:0046856","count":8},{"id":"GO:0043488","count":8},{"id":"GO:0045454","count":8}]},{"hash":"1734126087113334290","title":"Cardiac GPCR signaling and smooth muscle regulation","description":"Top terms converge on GPCR signaling with cardiovascular outcomes: blood pressure modulation, cardiac vascular smooth muscle differentiation, and muscle relaxation, along with acetylcholine and prostaglandin responses. This supports a cohesive GPCR-centric cardiovascular regulation theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0060408","count":11},{"id":"GO:0071380","count":11}]},{"hash":"1284600672439321827","title":"Unknown","description":"The top GO terms are scattered across RNA processing (mRNA splicing, snoRNP assembly, ribosomal export) and transcription/RNA regulation, plus signaling-related processes (ion transport, septate junction, glial BBB establishment, osteoclast differentiation). This diversity indicates no single shared function defining the cluster, so a specific functional label is not supported.","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:1903026","count":1},{"id":"GO:0032298","count":1},{"id":"GO:0000492","count":1},{"id":"GO:0000055","count":1}]},{"hash":"418267931581668960","title":"NF-kB Regulation and Adaptive Immunity","description":"This cluster is enriched for terms related to ubiquitination and negative regulation of NF-kappaB signaling, plus an adaptive immune response term, indicating a common theme of immune signaling and transcriptional regulation via NF-kB. Other terms touching on DNA repair, calcium transport, coagulation, and osteoclast development suggest broader connectivity in inflammation and immune-osteoclast cross-talk, but the strongest shared signal centers on NF-kB\u2013linked immune regulation rather than a single enzymatic function. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0043124","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0070588","count":2}]},{"hash":"356097638852649057","title":"Steroid Hormone Metabolism and Development","description":"The proteins show strong enrichment for steroid hormone biosynthesis/metabolism (aldosterone, progesterone, androgen) and hormone-related development (female gonad development). Additional terms for retinoic acid biosynthesis, vitamin D response, and epoxygenase P450 pathways point to shared involvement of cytochrome P450\u2013mediated metabolism and signaling. Together this suggests a cluster centered on hormone metabolism and related developmental pathways, with some xenobiotic metabolism context (camphor, ozone) mediated by P450 enzymes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":11},{"id":"GO:0008585","count":10},{"id":"GO:0008209","count":10},{"id":"GO:0019383","count":9},{"id":"GO:2001037","count":9}]},{"hash":"22246237836003785","title":"Meiosis Machinery and Nuclear Transport","description":"The top GO terms strongly point to meiotic chromosome segregation (female meiotic nuclear division, meiotic spindle elongation, centromeric sister chromatid cohesion) and nuclear import (NLS-bearing protein import into nucleus), suggesting a shared function around meiosis-related chromosome handling and nuclear trafficking. Additional terms (regulation of GTPase activity, desumoylation, TORC1 signaling) likely reflect broader regulatory layers that accompany meiosis. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":7},{"id":"GO:2001241","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0051754","count":7},{"id":"GO:0050790","count":6}]},{"hash":"1856384783359759025","title":"Vertebrate organogenesis: heart and nervous system","description":"These GO terms primarily point to vertebrate organogenesis, with strong emphasis on heart development (endocardial cushion migration, bundle of His/Purkinje structures, ventricular action potential regulation) and nervous system formation (nervous system development, dopaminergic axon guidance, corticospinal tract morphogenesis). A few terms reflect broader development such as ossification and marginal zone B cell differentiation, but the overall theme is organogenesis in heart and nervous system. Hence 'Vertebrate organogenesis: heart and nervous system' with Medium confidence.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0098911","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0086073","count":2},{"id":"GO:0021957","count":2}]},{"hash":"1556701743647090267","title":"Neural signaling and synaptic plasticity","description":"The top GO terms center on neuronal communication and plasticity, including social behavior, long-term synaptic depression, positive regulation of long-term neuronal synaptic plasticity, ephrin receptor signaling, and Rac pathway regulation, which together point to neural signaling networks and activity-dependent synaptic modulation. Some terms touch broader development (ey/skin morphogenesis, axial mesoderm formation), but the dominant pattern is neural signaling and plasticity mechanisms. Confidence: High","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0048681","count":2},{"id":"GO:0048170","count":2},{"id":"GO:0048320","count":2}]},{"hash":"1754210399947547684","title":"Innate Immunity and Tissue Remodeling","description":"These proteins show strong representation of innate immune signaling (innate immune response, defense against virus, LPS signaling, TLR signaling) along with cues for extracellular matrix and tissue remodeling (collagen fibril organization, regulation of angiogenesis, response to mechanical stimulus). This pattern suggests a core theme of immune-driven tissue remodeling rather than a single, cohesive metabolic or signaling pathway. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071372","count":4},{"id":"GO:0031663","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0071260","count":4}]},{"hash":"1875799443023647639","title":"Kidney morphogenesis and nephrogenesis","description":"The top terms are heavily skewed toward metanephric kidney development (distal/proximal tubule, mesonephric duct, tubule development, etc.), indicating a cohesive theme of nephrogenesis and renal morphogenesis. Additional terms touch on vascular/immune interactions, but the dominant signal points to kidney organ development and nephron formation.","confidence":"High","size":20,"edges":124,"triangles":368,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":14},{"id":"GO:0072287","count":14},{"id":"GO:0010572","count":14},{"id":"GO:0072218","count":14},{"id":"GO:0090403","count":14}]},{"hash":"823489301284237969","title":"Transmembrane Ion and Sugar Transporters","description":"The top GO terms repeatedly describe transmembrane transport of ions (K+, Na+), sugars (galactose, arabinose), and other small molecules, with an additional vesicular neurotransmitter loading term. This pattern indicates a cluster of membrane transporter proteins rather than a single substrate class, so a concise label like \"Transmembrane Ion and Sugar Transporters\" is appropriate.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0015757","count":4},{"id":"GO:0015751","count":4},{"id":"GO:0015739","count":4}]},{"hash":"1709817363110579640","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":3},{"id":"GO:0019076","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0015074","count":2}]},{"hash":"20448325459330242","title":"Neuronal synaptic signaling and plasticity","description":"The terms point to neuronal communication and synaptic changes, with emphasis on synaptic transmission (including GABAergic transmission), long-term potentiation, and vesicle priming. Additional terms related to Rho signaling and IP3 biosynthesis suggest connected intracellular signaling that modulates synapses, reinforcing a neural-communication theme. Overall, the cluster appears enriched for neuronal signaling and plasticity processes.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0060291","count":5},{"id":"GO:0032228","count":4},{"id":"GO:0060313","count":4},{"id":"GO:0016082","count":4}]},{"hash":"1180731858392775531","title":"Ribosome Biogenesis and Stress-Responsive Translation","description":"The cluster\u2019s strongest signals are ribosome-related (nuclear export of the large subunit, cytoplasmic translation, tRNA modification, and upregulation of gene expression), pointing to ribosome biogenesis and protein synthesis. Additional terms for Golgi to plasma membrane transport and stress responses suggest this ribosome-centric function operates within broader cellular trafficking and stress-adaptation contexts.","confidence":"High","size":20,"edges":9,"triangles":0,"max_degree":3,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0090051","count":6},{"id":"GO:0043001","count":6},{"id":"GO:0090324","count":6},{"id":"GO:0006400","count":5},{"id":"GO:0051301","count":5}]},{"hash":"1977242544480741550","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":9},{"id":"GO:0002188","count":9},{"id":"GO:0000398","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7}]},{"hash":"806377750865267176","title":"NOD-like immune signaling and ubiquitination","description":"This cluster is dominated by GO terms for NOD1/2 signaling pathways, protein ubiquitination, and intracellular signal transduction, suggesting a core theme of innate immune sensing and ubiquitin-mediated regulation. Additional terms like calcium import, pinocytosis regulation, and cell migration align with immune cell activation and movement, while follicular dendritic cell differentiation points to immune system involvement. Overall, the proteins appear to participate in NLR-mediated signaling and ubiquitin-dependent regulatory processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":8},{"id":"GO:0070427","count":8},{"id":"GO:0070431","count":8},{"id":"GO:0016567","count":8},{"id":"GO:0035556","count":8}]},{"hash":"853388941173616466","title":"Nuclear RNA export and processing","description":"This cluster is dominated by GO terms for exporting RNA from the nucleus (ribosomal subunits, mRNA, pre-miRNA) and for RNA processing (tRNA processing), pointing to a group centered on nucleocytoplasmic transport and RNA maturation. While there are a few terms related to cytoskeletal organization and development, the strongest signal is RNA export/processing, making this label representative and specific.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":5},{"id":"GO:0006406","count":5},{"id":"GO:0030953","count":4},{"id":"GO:0008033","count":4},{"id":"GO:0007270","count":4}]},{"hash":"1751752270535930128","title":"Vesicle trafficking and membrane exocytosis","description":"The top GO terms point strongly to membrane dynamics and cargo movement: Golgi-to-plasma-membrane transport, endocytic recycling, phospholipid homeostasis, and various aspects of vesicle exocytosis regulation. While there are ancillary developmental and chemotaxis terms, the cohesive theme across the cluster is vesicle trafficking and membrane remodeling, which ties together the transport steps and signaling that govern vesicle docking, fusion, and circulation in cells. Therefore the label reflects the central function of the group rather than isolated phenotypes.","confidence":"Medium","size":20,"edges":29,"triangles":3,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":5},{"id":"GO:0032456","count":5},{"id":"GO:0006893","count":5},{"id":"GO:2000300","count":5},{"id":"GO:0050919","count":5}]},{"hash":"478992009594613233","title":"Vesicle trafficking and exocytosis","description":"The top GO terms point to endomembrane transport (ER-to-Golgi), multivesicular body sorting, and various exocytosis and exocytosis-regulation processes, with some membrane repair and signaling associations. This suggests a cohesive theme of vesicle trafficking and membrane fusion events, rather than a single enzymatic function. Therefore, the label vesicle trafficking and exocytosis aptly captures the cluster\u2019s shared role.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0010796","count":2},{"id":"GO:0001778","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0031384","count":2}]},{"hash":"738144992714519867","title":"Collagen maturation and ER-Golgi transport","description":"This cluster centers on processes related to collagen biosynthesis and processing in the secretory pathway, including ER-to-Golgi transport, collagen fibril organization, and proline hydroxylation, which depends on oxygen. Zinc import may support metalloproteins involved in these steps. The combination strongly points to collagen maturation rather than unrelated functions.","confidence":"High","size":20,"edges":20,"triangles":1,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0030199","count":2},{"id":"GO:1901874","count":2},{"id":"GO:0018401","count":2},{"id":"GO:0032364","count":2}]},{"hash":"1823522288001883657","title":"Muscle calcium signaling and contraction","description":"Top GO terms indicate calcium ion detection, calcium release regulation, and promotion of heart contraction, along with skeletal muscle development, suggesting a core theme of calcium-dependent muscle function in cardiac and skeletal muscle. Some terms (GPI anchor biosynthesis, antibiotic/nylon catabolic processes, proteolysis) appear less directly related and may reflect annotation noise or multifunctionality. Overall, the cluster seems centered on muscle contraction and calcium signaling rather than a single non-muscle pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":3},{"id":"GO:0006508","count":2},{"id":"GO:0010881","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0098735","count":2}]},{"hash":"1712405333157499497","title":"Vertebrate Eye Development and Embryogenesis","description":"The cluster\u2019s top GO terms are dominated by eye morphogenesis and related embryonic development processes (embryonic eye morphogenesis, camera-type eye development, brain segmentation, primitive streak formation), with supporting transcriptional regulation terms (RNA polymerase II transcription). This points to a set of proteins involved in vertebrate embryogenesis, especially ocular development and associated morphogenetic events, rather than a narrow single-pathway function.","confidence":"Medium","size":20,"edges":133,"triangles":421,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0048048","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0035470","count":6},{"id":"GO:0002087","count":5}]},{"hash":"427691730736095910","title":"Innate Immune Signaling and Defense (TLR4/JNK)","description":"The terms point to a coherent innate immune theme: defense responses to Gram-positive bacteria and viruses, innate immune signaling, TLR4 pathway activity, dsRNA response, and JNK cascade regulation. While a couple terms (like male gonad development) are less related, the dominant signal is clearly innate immune recognition and downstream signaling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0051965","count":4}]},{"hash":"484143815101916498","title":"Cytoskeletal regulation and signaling","description":"The listed GO terms point to modulation of actin dynamics (negative regulation of Arp2/3\u2013mediated nucleation) along with broader signaling controls (positive regulation of protein serine/threonine kinase activity and GTPase activity). Stress- and growth-factor responses appear (cellular response to hypoxia, TGF-\u03b2 stimulus), plus cell cycle and translation-related processes that relate to cytoskeletal remodeling and cell division. Together, they suggest a cluster centered on regulating the cytoskeleton and associated signaling pathways under cellular stress.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034316","count":6},{"id":"GO:0071456","count":6},{"id":"GO:0051028","count":6},{"id":"GO:0071902","count":6},{"id":"GO:0043547","count":6}]},{"hash":"676655887428100038","title":"Endocytosis and Signal Transduction","description":"The top GO terms point to broad signaling roles (GPCR signaling pathway, positive regulation of GTPase activity, calcium import) alongside vesicle trafficking (pinocytosis) and transcription-related processes, with some immune-related hints (vitamin D response, follicular dendritic cell differentiation). This pattern suggests a cluster centered on general signal transduction coupled to endocytic/trafficking activities, rather than a single specific pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0033280","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000278","count":4}]},{"hash":"845126970629281697","title":"Antigen presentation and immune activation","description":"This cluster is dominated by GO terms tied to antigen processing and presentation via MHC class II, innate immune response, cytokine production, B cell activation, and T cell costimulation, indicating a core function in immune recognition and signaling. A couple of terms related to nervous system development and GI epithelium maintenance are present but appear less central to the main theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002588","count":4},{"id":"GO:0071224","count":4},{"id":"GO:0045087","count":4},{"id":"GO:2001181","count":4},{"id":"GO:0050871","count":4}]},{"hash":"1200785520590057562","title":"Neural Sensory Perception and Signaling","description":"This cluster centers on sensory perception across modalities (vision, taste, pain) and neural signaling pathways (GPCR signaling, receptor internalization, cAMP-related processes) plus related behaviors like locomotion, indicating a theme of neuronal sensory processing and signaling rather than a single metabolic function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007614","count":3},{"id":"GO:0050908","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0051930","count":2},{"id":"GO:0007196","count":2}]},{"hash":"595922923854721452","title":"GPCR-Calcium Signaling Cluster","description":"The GO terms point to GPCR signaling that activates calcium flux and kinase regulation, plus related processes like calcium import/release and downstream signaling modulation. There are also neuronal differentiation and broader signaling roles (visual perception, SA node regulation, cell migration, pinocytosis) that can be linked through the overarching theme of calcium- and GPCR-driven signal transduction across diverse cell types. Overall, a unifying theme around calcium signaling and GPCR pathways best fits the cluster, with some terms reflecting tissue-specific contexts. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0021707","count":4},{"id":"GO:0051209","count":4},{"id":"GO:0007601","count":3}]},{"hash":"997243748597242051","title":"Insect mating, egg-laying, and circadian regulation","description":"The top GO terms are dominated by mating-related and reproductive behaviors (male mating behavior, female receptivity post-mating, regulation of egg-laying, negative regulation of egg-laying) and by circadian rhythm regulation, which together point to a cluster of proteins involved in insect reproductive behavior and clock-controlled egg-laying. Additional signals for inflammatory response and pigmentation appear but are secondary to the main theme of reproduction and circadian control. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0008345","count":2},{"id":"GO:0002209","count":2},{"id":"GO:0048042","count":2},{"id":"GO:0045434","count":2}]},{"hash":"42466670894302168","title":"Cell Growth and Differentiation Signaling","description":"The top GO terms cluster around growth and proliferation (cell growth, cell cycle), differentiation of multiple lineages (skeletal muscle, anterior lateral line, follicular dendritic cells), and regulation of signaling via ubiquitination and kinase activity. This suggests proteins involved in growth control, differentiation programs, and broader signaling regulation rather than a single pathway, so a concise label that reflects growth and differentiation signaling fits best.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0010745","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0035556","count":3}]},{"hash":"1102168213586109018","title":"Regulation of signaling and membrane dynamics","description":"The listed GO terms cluster around regulation of signaling pathways (e.g., insulin receptor signaling, protein kinase activity) and membrane-associated processes (calcium import, pinocytosis, membrane depolarization), with additional notes on cell migration and localization. This suggests a theme of proteins that modulate signaling and membrane/trafficking functions, rather than a single, cohesive pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002268","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0071901","count":2},{"id":"GO:0098703","count":2},{"id":"GO:0048549","count":2}]},{"hash":"1671891021239163997","title":"T and B cell activation and differentiation","description":"Despite no interactions, the top GO terms point to adaptive immunity, including germinal center formation, memory T cell differentiation, pro-T cell differentiation, type 2 immune response, and isotype switching regulation. This suggests the proteins cluster around T and B cell activation and differentiation processes, with ubiquitin-dependent and ubiquitin-regulation pathways potentially modulating immune signaling. Some terms (phototropism, kainate receptor activity) appear unrelated or noisy, indicating annotation artifacts rather than core functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009638","count":3},{"id":"GO:0002467","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0045497","count":3},{"id":"GO:2000312","count":3}]},{"hash":"1888908406349603237","title":"Unknown","description":"The GO terms cover a broad mix of developmental, immune, neural, adhesion, and structural processes with no clear single shared function, so a unified label is not apparent.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001200","count":5},{"id":"GO:0007155","count":4},{"id":"GO:0060445","count":4},{"id":"GO:0033564","count":4},{"id":"GO:0007157","count":4}]},{"hash":"288795552196038460","title":"Retroelement Mobility and Proviral Latency","description":"The GO terms cluster around DNA integration, DNA transposition, retrotransposition, and establishment of integrated proviral latency, with additional mentions of viral entry into host cells. This indicates a cohesive theme of mobile genetic elements and proviral maintenance, rather than a single canonical cellular process. Some apoptosis-related terms may reflect host response rather than core function, but the primary signal is retroelement/proviral activity.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1478927827695386399","title":"Developmental signaling and organogenesis","description":"The proteins cluster around developmental processes across multiple organs (kidney, heart, nervous system, hippocampus) and involve key signaling pathways (Smoothened/SHH, Roundabout/ROBO) and synapse assembly, suggesting a shared theme of developmental signaling guiding organogenesis and neural connectivity.","confidence":"High","size":19,"edges":159,"triangles":792,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":8},{"id":"GO:0001822","count":8},{"id":"GO:0007224","count":8},{"id":"GO:0035385","count":8},{"id":"GO:0007399","count":8}]},{"hash":"1507079889030039486","title":"Nuclear transcriptional and epigenetic regulation in development","description":"The cluster centers on nuclear control of gene expression and chromatin state (negative regulation of Pol II transcription, negative regulation of DNA demethylation, histone methylation), plus cell cycle and development processes (centrosome cycle, mitotic cycle, placenta morphogenesis, spermatid differentiation), suggesting a developmental regulatory program rather than a single pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042403","count":4},{"id":"GO:1901536","count":4},{"id":"GO:0045869","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0060669","count":4}]},{"hash":"1130893203826309433","title":"Ubiquitin-Dependent Proteolysis in Meiosis and Development","description":"Top GO terms center on ubiquitin-dependent protein catabolic processes with links to meiosis-related spindle assembly, oocyte maturation, and broader developmental processes, suggesting a cluster focused on proteostasis in reproductive development and embryogenesis; scattered terms about circadian regulation and metal response may reflect broader regulatory roles of the ubiquitin system.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0042752","count":12},{"id":"GO:0046685","count":10},{"id":"GO:0051436","count":10},{"id":"GO:0006516","count":10}]},{"hash":"1309988810626338870","title":"Mitotic cell cycle control and transcription","description":"The top terms are dominated by mitotic progression (G1/S and G2/M transitions, spindle pole separation, re-entry into mitosis) and DNA-templated transcription, with a related chromosome condensation motif. While a few terms touch on proliferation in specific tissues or signaling pathways, the central theme clearly centers on mitosis and transcriptional regulation, suggesting a cohesive cluster of cell-cycle control proteins.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042220","count":11},{"id":"GO:0000082","count":9},{"id":"GO:0010696","count":9},{"id":"GO:0046626","count":9},{"id":"GO:0000086","count":9}]},{"hash":"1288101416307799116","title":"Sterol and lipid biosynthesis","description":"The top GO terms cluster around sterol biosynthesis (ergosterol and cholesterol pathways), fatty acid and ether lipid metabolism, and related lipid-modifying steps, suggesting the proteins form a lipid biosynthesis-related group. Some other terms (ABA signaling, B cell chemotaxis, CNS myelin maintenance) may reflect broad or off-target annotations rather than a core shared function. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000272","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0006633","count":2},{"id":"GO:0046485","count":2},{"id":"GO:0006696","count":2}]},{"hash":"428455261052423597","title":"DNA replication and repair cell cycle cluster","description":"Top terms are dominated by DNA replication, DNA-templated transcription, mitotic cell cycle, and DNA repair, each with strong representation, indicating a core theme of genome maintenance and cell-cycle control. The presence of apoptosis terms (execution phase) and innate immune response suggests stress signaling linked to DNA damage and subsequent cell fate decisions, aligning with a DNA damage response framework. Overall, the cluster centers on genome maintenance with associated stress responses.","confidence":"High","size":19,"edges":25,"triangles":6,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":18},{"id":"GO:0006351","count":18},{"id":"GO:0000278","count":18},{"id":"GO:0006281","count":18},{"id":"GO:0045087","count":17}]},{"hash":"2245885171354945924","title":"GPCR-cAMP Signaling in Blood Pressure Regulation","description":"This cluster is driven by GO terms for G protein-coupled receptor signaling and adenylate cyclase/cAMP regulation, including dopamine receptor signaling, acetylcholine metabolism, prostaglandin response, and renin-angiotensin\u2013mediated blood pressure control. The pattern points to a cohesive GPCR/cAMP signaling module with roles in neuromodulation and cardiovascular regulation; a few terms like electron transport chain and posterior midgut development appear as less central contexts.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":15},{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0007190","count":15},{"id":"GO:0001991","count":14}]},{"hash":"1590431607344084825","title":"Neuronal synapse formation and plasticity","description":"This cluster is dominated by GO terms tied to synapse formation and plasticity (dendritic spine morphogenesis, regulation of excitatory postsynaptic potentials, synapse structural plasticity, and long-term synaptic depression) and behavior-related terms (social and vocalization behaviors, sensory perception of sound). A minority term about epithelial polarity or NF-kappaB sequestration is less central, but the core signal points to neuronal synapse development and activity-driven behavioral outputs.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0060997","count":3},{"id":"GO:0007253","count":3},{"id":"GO:2000463","count":3},{"id":"GO:0071625","count":3}]},{"hash":"1084766675519949425","title":"Cardiac and skeletal muscle regulation and calcium signaling","description":"The cluster is enriched for GO terms related to muscle function and signaling, including cardiac/skeletal muscle contraction, skeletal muscle fiber development, hypertrophy in response to stress, calcium ion detection, and calcineurin-NFAT signaling regulation, plus hypoxia response and kinase activity regulation. These together point to a cohesive theme of muscle physiology and its calcium-dependent signaling pathways, with some ancillary regulatory processes reflected by the other terms.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":6},{"id":"GO:0060048","count":5},{"id":"GO:0007613","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0000278","count":5}]},{"hash":"977658961062554664","title":"Cranial skeletal development","description":"The strongest signals are skeletal-development terms, especially embryonic cranial skeleton morphogenesis and skeletal system development, indicating a focus on craniofacial bone formation. Supporting terms suggest linked endocrine and signaling roles (erythropoietin signaling, parathyroid hormone regulation), with additional transcriptional and apoptotic processes. While there is some functional diversity, the dominant theme is cranial skeletal development, hence this label with Medium confidence. ","confidence":"Medium","size":19,"edges":43,"triangles":0,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0048701","count":2},{"id":"GO:2000830","count":2},{"id":"GO:0046826","count":2}]},{"hash":"709642410389651415","title":"Monosaccharide Transporters and Membrane Trafficking","description":"This cluster centers on monosaccharide transport: glucose, galactose, and fructose import across membranes, suggesting a shared role in sugar uptake. The GO terms also emphasize membrane localization to the plasma membrane and organelles (Golgi, phagophore assembly site), indicating coordinated trafficking of transport proteins. Some outlier terms exist, but the dominant theme is sugar transport coupled with membrane trafficking.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":2},{"id":"GO:0000042","count":2},{"id":"GO:0034497","count":2},{"id":"GO:0072661","count":2},{"id":"GO:0048733","count":1}]},{"hash":"1769199836276155661","title":"Ubiquitin-Dependent Proteolysis and Circadian Regulation","description":"The dominant GO terms point to ubiquitin-dependent protein catabolic processes (including SCF-dependent proteasomal degradation and autoubiquitination) and ubiquitin linkages (K6), with additional links to histone turnover and regulation of circadian rhythm, suggesting a cluster centered on ubiquitin\u2013proteasome system activity and its circadian control. The presence of related signaling and stress-response terms (TNF signaling, oxidative-stress\u2013induced apoptosis) supports a role in proteostasis and cellular stress responses tied to ubiquitination.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0042752","count":8},{"id":"GO:0085020","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0036205","count":8}]},{"hash":"2000162844076305030","title":"Neural development and transcriptional regulation","description":"This cluster is dominated by terms related to brain development (cerebral cortex development, neuron maturation, in utero embryonic development, pituitary gland development) and transcriptional control (DNA-templated transcription, regulation of transcription by RNA polymerase II), with chromatin modification hints (histone H3-K9 methylation). A few immune-related terms (response to lipopolysaccharide) and apoptosis appear but are secondary. Confidence reflects a coherent brain-development and transcriptional-regulation theme.","confidence":"High","size":19,"edges":11,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032496","count":8},{"id":"GO:0001701","count":8},{"id":"GO:0021983","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0051573","count":6}]},{"hash":"1404378987254496113","title":"RNA Processing and Translation","description":"The top GO terms are dominated by RNA metabolism and translation-related processes (translation initiation, translation reinitiation, mRNA splicing, RNA editing, and regulation of rRNA processing), pointing to a cohesive theme of RNA processing and protein synthesis control. A few outlier terms (lipid biosynthesis and nucleotide catabolism) are present but do not override the central RNA-focused signal.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0006378","count":3},{"id":"GO:0046067","count":2}]},{"hash":"2029365587825016176","title":"Unknown","description":"The GO terms are diverse (pain response, telomere maintenance, cell migration, calcium transport, pinocytosis, cardiac action potential) with no clear common function linking the proteins, so no meaningful cluster label beyond Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":6},{"id":"GO:0002268","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0071901","count":5},{"id":"GO:0098703","count":5}]},{"hash":"1178561081286560432","title":"Diverse Membrane Transporters","description":"The set of GO terms is dominated by transmembrane transport activities for potassium ions, nitrate, sugars like galactose and fucose, sialic acid, vitamins, and even neurotransmitter loading into synaptic vesicles; together they indicate a cluster of diverse membrane transporter proteins handling multiple substrates.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":7},{"id":"GO:0015739","count":6},{"id":"GO:0015706","count":6},{"id":"GO:0042891","count":6},{"id":"GO:0098700","count":6}]},{"hash":"1130948283341426098","title":"Ribosome Biogenesis and Cell Cycle","description":"This cluster is dominated by ribosome-related processes (ribosome biogenesis, ribosomal subunit export from nucleus, tRNA modification) and cell cycle components (cell cycle, cell division), indicating a cohesive group of proteins involved in ribosome assembly and coordination of protein synthesis with cell division.","confidence":"High","size":19,"edges":42,"triangles":20,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":18},{"id":"GO:0000055","count":18},{"id":"GO:0007049","count":18},{"id":"GO:0006400","count":16},{"id":"GO:0000747","count":16}]},{"hash":"1466619126354230103","title":"Presynaptic vesicle trafficking and neurotransmitter release","description":"The top GO terms cluster around presynaptic vesicle maturation, docking, and exocytosis, plus neurotransmitter secretion and related synaptic signaling (including Reelin-mediated pathways). This pattern points to a group of proteins functioning together in assembling, trafficking, and releasing neurotransmitters from presynaptic vesicles, with possible modulation by signaling pathways affecting synaptic plasticity. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007269","count":3},{"id":"GO:0099525","count":3},{"id":"GO:0016188","count":3},{"id":"GO:0038026","count":3},{"id":"GO:0048280","count":2}]},{"hash":"1817861367449443915","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning sensory perception of sound, cerebellar neuron differentiation, neuronal signaling, heart development and cardiac muscle contraction, calcium transport, acrosome reaction, and metabolism. There is no single dominant function or pathway shared by most proteins in this cluster, so a specific, representative label cannot be confidently assigned.  ","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0098703","count":2},{"id":"GO:0007340","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0007205","count":2}]},{"hash":"1759563736743954036","title":"Neural Development and ER-Golgi Trafficking","description":"The cluster is enriched for neural development terms (brain development, nervous system development, neural tube closure) and vesicle trafficking between the ER and Golgi (ER-Golgi and Golgi-ER transport), with ERK signaling and ER-stress\u2013related apoptotic pathways also represented. Together, these suggest a coherent theme around neural development supported by secretory pathway dynamics and signaling, even though some cell-cycle terms appear as well. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0007420","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0000278","count":4}]},{"hash":"2123075451771327340","title":"Cytoskeleton remodeling and phagocytosis","description":"Top GO terms cluster around phagocytosis, Rac-mediated actin remodeling, and cytoskeletal organization, with links to cell migration and dynein/flagellar assembly. This suggests a cohesive theme of cytoskeleton-driven remodeling and related cellular processes, including engulfment and motility; a few terms appear peripheral and may reflect incidental associations.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006911","count":2},{"id":"GO:0016601","count":2},{"id":"GO:0045725","count":2},{"id":"GO:0034383","count":2},{"id":"GO:2000574","count":1}]},{"hash":"61471241626379674","title":"Vertebrate neural and vascular development","description":"The top GO terms are dominated by neural development (axonogenesis, axon extension, corpus callosum development, forebrain development) and vascular signaling (VEGF receptor signaling), suggesting a common theme of developmental processes in vertebrate nervous and vascular systems. Some immune-related terms appear, likely reflecting shared signaling components rather than a single cohesive function, so the overall label centers on development rather than immunity. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0048846","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0071260","count":4}]},{"hash":"750695850609337499","title":"Organ development and tissue homeostasis","description":"The cluster is overall enriched for terms related to organogenesis and tissue maintenance, including lymph vessel morphogenesis, metanephric tubule development, multicellular organism growth, and homeostasis of cell numbers within a tissue, along with endocytic recycling and regulation of cell size. While innate immune response and platelet activation are present, the dominant theme appears to be developmental morphogenesis and maintenance of tissue architecture. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0036303","count":2},{"id":"GO:0072287","count":2},{"id":"GO:0010572","count":2},{"id":"GO:0072237","count":2}]},{"hash":"546834421255146755","title":"Ribosome Biogenesis and tRNA Modification","description":"This cluster is dominated by GO terms for ribosome biogenesis and tRNA modification (e.g., tRNA modification, ribosome biogenesis, ribosomal small subunit biogenesis), pointing to proteins involved in assembling and configuring ribosomes and translation machinery. Additional terms related to cell cycle and metabolism suggest growth coordination that accompanies ribosome production, but the core theme remains ribosome assembly and RNA processing. ","confidence":"Medium","size":19,"edges":83,"triangles":162,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006400","count":9},{"id":"GO:0007049","count":9},{"id":"GO:0000747","count":9},{"id":"GO:1901001","count":9},{"id":"GO:0039707","count":9}]},{"hash":"934928192019294775","title":"Unknown","description":"The top GO terms are highly heterogeneous, including animal development (prostate gland development, male sex differentiation), plant processes (negative regulation of chlorophyll biosynthetic process), cell cycle and APC-dependent catabolic processes, stress responses (cadmium ion, dsRNA), and ubiquitination, with several obsolete terms. This lack of a coherent, shared functional theme across the cluster suggests no interpretable single function for the group.","confidence":"","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030850","count":4},{"id":"GO:1902325","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0046661","count":4}]},{"hash":"674396081369279417","title":"Immune signaling and calcium dynamics","description":"This cluster is dominated by terms tied to signaling and calcium regulation (calcium release into cytosol, calcium import across the membrane, Wnt signaling, IL-1 response) and immune-related processes (follicular dendritic cell differentiation, cell migration, pinocytosis), suggesting a common theme of immune signaling modulated by calcium dynamics. An outlier term for mRNA processing is present, but the overall pattern points to signaling and calcium-related functions rather than a single core activity. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0071347","count":2},{"id":"GO:0002268","count":2}]},{"hash":"888630877848827818","title":"Unknown","description":"The top GO terms are highly diverse, including pain response, telomere maintenance via telomerase, cell cycle, dendritic cell differentiation, cell migration, kinase activity regulation, calcium transport, pinocytosis, and cardiac membrane depolarization. There is no single cohesive function linking these terms, so a generic or unknown label is most appropriate.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":6},{"id":"GO:0032212","count":5},{"id":"GO:0007049","count":5},{"id":"GO:0002268","count":4},{"id":"GO:0016477","count":4}]},{"hash":"2208177670253948378","title":"Mechanotransduction and Calcium Signaling","description":"These proteins show enrichment for responses to mechanical stimulus and calcium-related signaling (cellular response to mechanical stimulus; calcium ion import across plasma membrane; cell migration; PKC pathway signaling; heat/stress responses), suggesting a mechanotransduction/calcium signaling theme. Some terms appear as outliers (dendritic cell differentiation, telomere maintenance), likely annotation noise, but the core signals support the mechanosensitive calcium signaling interpretation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":6},{"id":"GO:0002268","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0071901","count":5},{"id":"GO:0098703","count":5}]},{"hash":"329217513810171729","title":"Unknown","description":"The top GO terms show a mix of membrane transport, endosomal processes, xenobiotic response, and various metabolic/biosynthetic activities, including a neuroscience-specific term and a bacterial cell wall biosynthesis term. The proteins have no reported interactions (edges/triangles are zero) and lack a unifying function, so there isn\u2019t a cohesive theme to name beyond Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0048388","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0045493","count":2},{"id":"GO:0021680","count":2}]},{"hash":"140226109442824773","title":"Inner ear development and hearing","description":"The top GO terms cluster around ear morphogenesis (cochlea morphogenesis, otolith morphogenesis), sensory perception of sound, and receptor localization to synapse, suggesting a shared role in inner ear development and auditory signaling. Some terms (DNA transposition, proteolysis, tRNA methylation) seem incidental and don\u2019t define a single cohesive theme, so the core signal remains inner ear and hearing functions.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0001935","count":2},{"id":"GO:0090103","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0071333","count":2}]},{"hash":"317776053967287797","title":"Mitotic progression and chromosome condensation","description":"The top GO terms are dominated by mitosis and cell cycle regulation: G1/S and G2/M transitions, kinetochore localization, spindle pole separation, re-entry into mitosis, and histone H3-S10 phosphorylation linked to chromosome condensation. This points to a cohesive set of proteins coordinating mitotic progression and chromosome dynamics, with transcription-related terms likely reflecting broader cell-cycle control; peripheral signals like insulin signaling regulation are less central. ","confidence":"High","size":18,"edges":111,"triangles":386,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":15},{"id":"GO:2000775","count":14},{"id":"GO:0033598","count":14},{"id":"GO:0006351","count":14},{"id":"GO:0000086","count":14}]},{"hash":"1417580778098169013","title":"Developmental transcription and MAPK signaling","description":"This cluster centers on transcriptional programs involved in development, with supporting signaling and inflammatory cues. The prominent GO terms include DNA-templated transcription and regulation of transcription factor activity, alongside developmental processes (face development, placental and chondrocyte growth, adipocyte differentiation) and signaling (p38 MAPK cascade) and immune response (lipopolysaccharide). This suggests a cohesive theme of developmental transcription regulation modulated by MAPK signaling, with some inflammatory context.","confidence":"Medium","size":18,"edges":19,"triangles":2,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0043433","count":8},{"id":"GO:2001275","count":8},{"id":"GO:0003430","count":8},{"id":"GO:0045444","count":8}]},{"hash":"1010809224250289563","title":"DNA replication and cell cycle regulation","description":"The top GO terms cluster around nuclear processes\u2014DNA replication, DNA-templated transcription, chromatin modification (histone H3 S10 phosphorylation) and chromosome condensation\u2014as well as cell-cycle control (G2/M transition). Some development- and signaling-related terms are present, but the core pattern points to fundamental nuclear activities governing proliferation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0042503","count":5},{"id":"GO:2000775","count":5},{"id":"GO:0033598","count":5}]},{"hash":"8256286285039213","title":"Regulation of signaling and protein degradation","description":"This cluster's top GO terms converge on controlling signaling outputs (T cell receptor signaling, JNK cascade regulation, cellular response to estrogen) and on protein homeostasis (negative regulation of autophagosome assembly, proteasomal degradation). Additional terms like DNA replication and neuron development hint at broader regulatory roles rather than a single pathway, suggesting a loose, multi-functional regulatory module rather than a tightly cohesive process.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0046330","count":3},{"id":"GO:0043433","count":3}]},{"hash":"457679567129739681","title":"Unknown","description":"Top terms are not provided, so there is no clear shared function or process to define a label for this cluster. Without GO term signals, a specific, representative name cannot be determined.","confidence":"","size":18,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[]},{"hash":"378631245742625902","title":"Amino acid and vitamin biosynthesis with signaling","description":"This cluster shows strong representation of amino acid and cofactor biosynthesis: L-serine biosynthesis, L-cysteine catabolic process, pyridoxine (vitamin B6) biosynthesis, and quinolinate (NAD) biosynthesis, plus iron-sulfur cluster maturation. There are also signaling-related terms (response to cAMP, Notch signaling pathway, response to glucocorticoid). The combination suggests a metabolic focus with regulatory signaling links, rather than a single clean pathway. The proposed name captures the core biosynthetic theme while noting the signaling annotations.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051591","count":8},{"id":"GO:0006564","count":8},{"id":"GO:0007219","count":7},{"id":"GO:0018283","count":7},{"id":"GO:0034516","count":7}]},{"hash":"1807480801342412113","title":"Blood Pressure Regulation via GPCR-AC Signaling","description":"The cluster shows strong enrichment for GO terms related to blood pressure regulation and GPCR-mediated activation of adenylate cyclase, including renin-angiotensin pathways and dopamine receptor signaling, along with acetylcholine metabolism and prostaglandin responses, indicating a cohesive cardiovascular signaling module. Some energy metabolism and development terms appear as ancillary signals, but the dominant pattern is GPCR-AC\u2013driven cardiovascular regulation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":14},{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0007190","count":14},{"id":"GO:0001991","count":12}]},{"hash":"195826606025015302","title":"N-terminal protein modifications and polyamine acetylation","description":"The cluster shows a clear pattern of post-translational modifications centered on N-terminal acetylation/propionylation (e.g., N-terminal peptidyl-methionine acetylation and N-terminal protein amino acid propionylation) and acetylation of polyamines (spermidine and spermine), suggesting a shared theme of protein N-terminal modifications and polyamine metabolism. Some terms like angiogenesis or leaf formation are outliers, but the dominant signal is PTMs involving acetylation and related amine chemistry.","confidence":"Medium","size":18,"edges":47,"triangles":48,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001525","count":16},{"id":"GO:0045150","count":13},{"id":"GO:0017196","count":12},{"id":"GO:0019491","count":12},{"id":"GO:0009447","count":12}]},{"hash":"1873664426470512155","title":"Cardiovascular GPCR signaling","description":"The proteins are enriched for GO terms related to GPCR signaling and cardiovascular regulation, including renin-angiotensin\u2013mediated blood pressure control, dopamine and acetylcholine signaling, prostaglandin response, and vascular smooth muscle differentiation. While there are also immune and developmental terms, the strongest common theme centers on GPCR-driven signaling impacting cardiovascular function. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":16},{"id":"GO:0007195","count":16},{"id":"GO:0060408","count":16},{"id":"GO:0007497","count":16},{"id":"GO:0006955","count":16}]},{"hash":"1143400516919033378","title":"GPCR-cAMP Signaling in Blood Pressure Regulation","description":"This cluster is dominated by GO terms related to GPCR signaling that modulates adenylate cyclase activity, including dopamine receptor signaling, renin-angiotensin\u2013dependent blood pressure regulation, prostaglandin response, and acetylcholine metabolism. While there are outliers such as electron transport chain and midgut development terms, the strongest signals point to cardiovascular GPCR-cAMP signaling pathways governing blood pressure.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":17},{"id":"GO:0010579","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0007190","count":17},{"id":"GO:0001991","count":14}]},{"hash":"2189399991523953237","title":"Developmental patterning and morphogenesis (Wnt signaling)","description":"The terms cluster around embryonic development and morphogenesis, with axis specification (anterior/posterior), hindlimb morphogenesis, organ boundary specification, and imaginal disc growth regulation, all tied to signaling activities, notably the Wnt pathway. Extracellular matrix remodeling (heparan sulfate proteoglycan catabolic process) supports coordinated morphogenetic processes. Overall, the cluster reflects development and patterning across tissues rather than a single biochemical function.","confidence":"High","size":18,"edges":39,"triangles":14,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0030200","count":2},{"id":"GO:0009948","count":1},{"id":"GO:0035116","count":1},{"id":"GO:0060030","count":1},{"id":"GO:0030282","count":1}]},{"hash":"160730674804131706","title":"Neuronal Morphogenesis and Axon Guidance","description":"The top GO terms cluster around neural development, including dendritic spine morphogenesis and development, axon guidance (commissural and motor neuron fasciculation), and synaptic plasticity, indicating a theme of neuronal connectivity and synapse formation. A few terms touch on broader developmental signaling (hedgehog/smoothened) or non-neural processes, but the dominant signal is neuronal morphogenesis and guidance.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":3},{"id":"GO:0002042","count":3},{"id":"GO:0045880","count":3},{"id":"GO:0071679","count":3},{"id":"GO:0001867","count":2}]},{"hash":"3877060513243338","title":"Steroid Hormone Biosynthesis and Temperature Response","description":"This cluster centers on steroid hormone biosynthesis (aldosterone and cortisol) and temperature-related responses (diet-induced thermogenesis, cellular response to temperature stimulus), with supporting signals like calcium release and vitamin D response. While there are also general cellular processes like ubiquitination and oligomerization, the strongest shared signal is endocrine/metabolic regulation under thermal stress, justifying a label around steroid biosynthesis combined with temperature responsiveness.","confidence":"Medium","size":18,"edges":17,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0051209","count":5},{"id":"GO:0032342","count":5}]},{"hash":"809059969329854245","title":"Neural development and lipid/ECM biosynthesis","description":"The cluster is characterized by neural-development terms (cerebellar Purkinje cell layer development; neurotrophin TRK receptor signaling) and membrane/ECM biosynthesis (glycosphingolipid, sterol, and chondroitin sulfate proteoglycan biosynthesis). This combination suggests proteins involved in neural differentiation and maintenance with membrane lipid composition and extracellular matrix remodeling. Some terms are obsolete, but the core theme remains neural development and lipid/ECM biosynthesis.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":4},{"id":"GO:0050650","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0016126","count":2}]},{"hash":"2253793647526730018","title":"Vascular and immune signaling","description":"The top GO terms cluster around vascular regulation (blood coagulation, blood pressure), immune cell recruitment (monocyte chemotaxis), and signaling cascades (ERK1/2), with complementary processes in renal function, xenobiotic response, and tissue development (collagen, lung, astrocyte). This suggests a unifying theme of systemic vascular-immune signaling rather than a single specific function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0045777","count":2},{"id":"GO:0090026","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0035815","count":2}]},{"hash":"2098317729761811856","title":"Plant cell wall polysaccharide biosynthesis","description":"This cluster is dominated by GO terms for plant cell wall component synthesis and modification, including homogalacturonan and glucuronoxylan biosynthesis, mucilage and plant-type secondary cell wall biogenesis, and related carbohydrate metabolism and glycosylation processes. An outlier term about skeletal muscle tissue regeneration appears incidental; overall, the proteins seem linked to plant cell wall polysaccharide production and glycosylation. ","confidence":"High","size":18,"edges":40,"triangles":17,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0071555","count":1},{"id":"GO:0010289","count":1},{"id":"GO:0006012","count":1},{"id":"GO:0009834","count":1}]},{"hash":"742187771516182683","title":"Rho-Actin Remodeling in Migration and Synaptic Signaling","description":"The top GO terms cluster around actin cytoskeleton organization, lamellipodium assembly, and positive regulation of GTPase activity, all pointing to Rho-actin\u2013driven remodeling. They are linked to cell migration and neural signaling pathways (ephrin receptor signaling, JNK cascade) and to synapse structural plasticity and even social behavior, indicating a shared theme of cytoskeletal dynamics governing movement and neuronal connectivity. Heart development appears as a broader developmental context, but the core signal is actin/Rho\u2013mediated remodeling affecting migration and synaptic function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0035023","count":5},{"id":"GO:0030036","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0051835","count":5}]},{"hash":"480417949563072028","title":"Developmental Transcription Regulators (Pol II)","description":"The cluster is enriched for GO terms related to transcription regulation by RNA polymerase II (both negative and positive), alongside developmental processes such as midbrain and cartilage development and broader multicellular organism development. This points to proteins that orchestrate transcriptional programs during development, likely transcription factors or regulators active in brain and tissue formation. Some terms like behavior or detoxification are broader associations, but the dominant theme is Pol II\u2013guided transcriptional control in development.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0045944","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0051216","count":4},{"id":"GO:0007275","count":3}]},{"hash":"2263095122458548053","title":"Immune signaling and RNA regulation","description":"This cluster shows several GO terms tied to immune pathways (positive regulation of TNF signaling, IL-17 signaling, and chemokine production) alongside RNA-based gene regulation (miRNA-mediated silencing and translation inhibition). Together they suggest proteins involved in modulating immune responses and post-transcriptional control, with a few housekeeping processes like actin ubiquitination and peptide amidation present as broader cellular functions.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":2},{"id":"GO:1903886","count":2},{"id":"GO:2000637","count":2},{"id":"GO:1902187","count":2},{"id":"GO:0072089","count":2}]},{"hash":"967235483171348494","title":"Platelet-leukocyte adhesion and complement activation","description":"Top terms point to immune cell adhesion and inflammatory signaling, with strong signals for platelet activation, leukocyte tethering/rolling, and lectin-pathway complement activation, plus integrin-mediated signaling. While there are some development- or junction-related terms (vascular morphogenesis, metanephric development, septate junction assembly) present, the dominant pattern centers on immune-vascular interactions and inflammatory responses. Confidence: Medium","confidence":"","size":18,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":3},{"id":"GO:0050901","count":3},{"id":"GO:0001867","count":3},{"id":"GO:2001046","count":3},{"id":"GO:0090528","count":3}]},{"hash":"1744990989933185238","title":"Mitotic Regulation and Growth Signaling Regulators","description":"The GO terms cluster around mitosis and cell division (mitotic spindle assembly, mitotic cell cycle, cell division) and key growth signaling pathways (ERK/MAPK cascade, TORC1). Additional terms point to adhesion and developmental signaling, suggesting these proteins broadly regulate proliferation and signaling contexts. So a name emphasizing mitotic control and growth signaling best fits the group.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0051301","count":2},{"id":"GO:1904263","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1683060768818739248","title":"Developmental morphogenesis and cytoskeletal signaling","description":"The terms point to organ and tissue development (aorta, ventricular septum, palate roof), combined with neuronal axon localization and regulation of Rho/small GTPase signaling, which collectively emphasize cytoskeletal dynamics during development. Additional terms on autophagy regulation and amino acid starvation suggest supportive cellular signaling and stress responses that can intersect with morphogenetic processes, supporting a cohesive theme around developmental morphogenesis driven by cytoskeletal signaling pathways.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0060021","count":1},{"id":"GO:0051058","count":1},{"id":"GO:2000785","count":1}]},{"hash":"423340895629093513","title":"Axon guidance and neural crest migration","description":"The top GO terms cluster around neural development focused on axon guidance and neural crest migration, including branchiomotor neuron axon guidance, trigeminal nerve organization, axonal fasciculation, sympathetic neuron projection guidance, and semaphorin-plexin signaling. Adhesion terms (heterophilic/homophilic cell\u2013cell adhesion) further support axon pathfinding and fasciculation, indicating a cohesive theme of neural wiring and crest-derived cell migration. ","confidence":"High","size":18,"edges":66,"triangles":69,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021785","count":6},{"id":"GO:0007413","count":6},{"id":"GO:0021637","count":6},{"id":"GO:0036486","count":6},{"id":"GO:0097490","count":6}]},{"hash":"468439707864721645","title":"Telomere Maintenance Regulators","description":"The top GO terms cluster around telomere maintenance, telomere capping, and telomeric localization, indicating a shared role in chromosome end protection; additional terms (Wnt signaling, spindle assembly, ADP-ribosylation) appear but do not define the core function, so a telomere-focused label is most representative.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070198","count":5},{"id":"GO:1904357","count":5},{"id":"GO:0032212","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0051225","count":5}]},{"hash":"752395443596327909","title":"P450-driven steroid and retinoid biosynthesis","description":"The top GO terms cluster around cytochrome P450\u2013mediated biosynthetic pathways: aldosterone, cortisol, progesterone, 9-cis-retinoic acid, calcitriol, and the epoxygenase P450 pathway. Additional terms point to xenobiotic metabolism (camphor catabolic process, ozone response), all of which are commonly mediated by P450 enzymes. This suggests a cohesive theme of P450-driven biosynthesis and detoxification. ","confidence":"High","size":18,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019383","count":15},{"id":"GO:2001037","count":15},{"id":"GO:0042904","count":15},{"id":"GO:0032342","count":15},{"id":"GO:0010193","count":15}]},{"hash":"736202977953870488","title":"Wnt signaling and bone morphogenesis regulators","description":"These proteins appear linked to developmental signaling and tissue morphogenesis, especially regulation of canonical Wnt signaling and bone formation processes. The strongest terms are involved with Wnt pathway regulation and osteoblast differentiation/ossification, while other terms point to morphogenesis in heart and various organs, plus supporting signaling cascades like ERK and GTPase activity. This suggests a cohesive theme around developmental signaling with a focus on bone formation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0045668","count":3},{"id":"GO:0071157","count":2},{"id":"GO:2001240","count":2},{"id":"GO:0003148","count":2}]},{"hash":"1225382551580329691","title":"ECM Organization and Cell Adhesion","description":"This cluster\u2019s top GO terms cluster around collagen fibril organization, tendon development, integrin biosynthetic process, and general cell adhesion, pointing to extracellular matrix (ECM) remodeling and cell\u2013matrix interactions as a unifying theme. While there are additional signals related to synapse maturation and pain response, the strongest and most frequent signals relate to ECM and adhesion processes, suggesting a connective tissue/adhesion-focused cluster with some neuronal overlap.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":3},{"id":"GO:0050873","count":2},{"id":"GO:0040015","count":2},{"id":"GO:0048235","count":2},{"id":"GO:0097119","count":2}]},{"hash":"1297317318412906804","title":"Complement-mediated inflammation and coagulation","description":"This cluster is dominated by GO terms linked to innate immune activation and coagulation: classical and lectin complement activation, response to lipopolysaccharide, and blood coagulation. Collagen catabolic process suggests ECM remodeling during inflammation. Some terms about midbrain development and transcription regulation appear but seem less connected; overall, the strongest signal is immune/inflammatory and coagulation-related, justifying this label.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0007596","count":7},{"id":"GO:0045944","count":7},{"id":"GO:0006958","count":7}]},{"hash":"558962980785169125","title":"Organogenesis and tissue development","description":"The proteins in this cluster are enriched for GO terms related to development and formation of organs and their supporting tissues\u2014somitogenesis and various organ morphogenesis (cardiac vasculature, pulmonary valve, renal glomeruli, renal interstitial fibroblasts). While a few terms touch on signaling regulation or metabolism, the dominant theme is organogenesis and tissue formation across multiple systems.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":15},{"id":"GO:0045668","count":15},{"id":"GO:0045821","count":14},{"id":"GO:0001756","count":14},{"id":"GO:0043433","count":14}]},{"hash":"488269760137803210","title":"P450-driven steroid hormone biosynthesis and xenobiotic metabolism","description":"The top GO terms point to cytochrome P450\u2013mediated processes: epoxygenase P450 pathways, biosynthesis of multiple steroids (aldosterone, cortisol, progesterone), and xenobiotic/carbazole/camphor catabolic activities. This suggests a cluster enriched for P450 enzymes handling both steroid hormone production and xenobiotic metabolism, with a few odd developmental terms likely noise.","confidence":"Medium","size":18,"edges":40,"triangles":18,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":10},{"id":"GO:0019383","count":9},{"id":"GO:2001037","count":9},{"id":"GO:0042904","count":9},{"id":"GO:0032342","count":9}]},{"hash":"270849109198410455","title":"Embryonic heart and vascular development","description":"Proteins are enriched for embryonic mesoderm-derived organogenesis, especially heart development and endothelial morphogenesis, with BMP signaling regulation supporting cardiovascular patterning. While kidney development and other growth terms appear, the core theme centers on heart and vascular formation during embryogenesis.","confidence":"High","size":18,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0048378","count":2},{"id":"GO:0030513","count":2},{"id":"GO:0007507","count":2}]},{"hash":"654648184004429418","title":"Ubiquitin-Dependent Protein Degradation","description":"The strongest signal in the terms is ubiquitin-dependent protein catabolic process, with a notable additional item on negative regulation of ubiquitination, suggesting a core theme around ubiquitin-mediated protein turnover. The other terms span diverse developmental and physiological processes (nervous system development, skeletal muscle differentiation, germinal center formation, swimming), indicating the cluster may be functionally heterogeneous beyond ubiquitin pathways. Hence the label highlights the central ubiquitin-proteasome\u2013related function while acknowledging broader, less cohesive annotations.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0007399","count":6},{"id":"GO:0009638","count":6},{"id":"GO:0035914","count":6},{"id":"GO:0002467","count":6}]},{"hash":"1420693722948309767","title":"Unknown","description":"The top GO terms are a mix of developmental, reproductive, and general cellular processes (e.g., germ-line encapsulation, pregnancy, prostate development, left-right asymmetry, translation initiation, deneddylation), with no clear single theme linking all proteins. This lacks a cohesive functional signal for a specific label.","confidence":"","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048140","count":2},{"id":"GO:0000338","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0007565","count":2}]},{"hash":"2024201059264773113","title":"Neuronal development and synaptic regulation","description":"The cluster shows a clear emphasis on neural development (substantia nigra development) and synaptic function (regulation of synaptic vesicle exocytosis and endocytosis) along with related behavioral context (fear response). Calcium import into mitochondria and redox homeostasis support neuronal signaling and energy needs, strengthening the neuronal/brain-focused theme. Some cell-cycle and gluconeogenesis terms appear but are less central to the dominant neural/synaptic pattern.","confidence":"Medium","size":18,"edges":19,"triangles":10,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0051291","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0090526","count":3},{"id":"GO:0036444","count":3}]},{"hash":"806045567134952385","title":"NF-kappaB\u2013mediated immune signaling","description":"Based on the top GO terms, the cluster centers on regulation of canonical NF-kappaB signaling together with innate immune response and T cell modulation (costimulation and apoptosis), with supporting links to calcium signaling and xenobiotic/antibiotic responses. This pattern points to a cohesive set of proteins involved in NF-kappaB\u2013driven immune signaling and cross-talk between innate and adaptive immunity rather than a metabolic or structural module.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":3},{"id":"GO:0051092","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0014808","count":2}]},{"hash":"855594773032187390","title":"Synaptic and Platelet Granule Secretion","description":"This cluster is driven by GO terms for neurotransmitter secretion, presynaptic dense core vesicle exocytosis, and synaptic vesicle maturation, alongside platelet degranulation and platelet formation. These collectively point to secretory vesicle processes in neurons and platelets, indicating a shared functional theme despite a few less central terms (pigmentation regulation, TNF signaling).","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007269","count":4},{"id":"GO:0035855","count":3},{"id":"GO:0099525","count":3},{"id":"GO:0048070","count":3},{"id":"GO:0002576","count":3}]},{"hash":"928395256372340238","title":"Cranial nerve development and axon guidance","description":"The GO terms strongly point to neural development and axon pathfinding, with multiple entries for cranial nerve-related processes: trigeminal ganglion development, facial nerve structural organization, vestibulocochlear nerve organization, branchiomotor and sensory neuron axon guidance, and axon extension in guidance. While a couple of terms reference leukocyte tethering/rolling and angiogenesis, these are less central to the cluster's core signal, which is neural development and axon navigation. Thus the label reflects the dominant theme and is likely representative of the cluster's function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050901","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0060978","count":2},{"id":"GO:0021828","count":2},{"id":"GO:0097374","count":2}]},{"hash":"1922993166758236286","title":"Neuroendocrine development and calcium signaling","description":"Top terms cluster around calcium signaling (cellular response to calcium ion; ryanodine receptor activity) and neuroendocrine development (axonogenesis; adenohypophysis morphogenesis; thyroid hormone metabolism). While a few terms (visual perception; obsolete glycosylation/biosynthesis) appear peripheral or outdated, the predominant theme appears to be calcium-dependent neural/endocrine development, justifying a label focusing on these processes.","confidence":"Medium","size":18,"edges":25,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042403","count":4},{"id":"GO:0035690","count":3},{"id":"GO:0071277","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0006486","count":3}]},{"hash":"1996351875996397679","title":"Axon fasciculation and synapse development","description":"The top GO terms cluster around neuronal connectivity: axon fasciculation, receptor clustering, cell adhesion, dendritic spine morphogenesis, and regulation of synapse assembly. Together they point to how neurons connect and form synapses, with adhesion-mediated processes guiding axon bundling and synaptic maturation. Some terms (e.g., craniofacial development, angiogenesis) may reflect broader developmental programs or shared adhesion mechanisms, but the core signal is neuronal adhesion-driven connectivity and synapse formation.","confidence":"Medium","size":18,"edges":34,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0034446","count":4},{"id":"GO:0097155","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0048671","count":3},{"id":"GO:0055114","count":3}]},{"hash":"481106110942536337","title":"Immune activation and signaling","description":"The terms cluster around immune cell activation and signaling, including NF-kappaB and JNK pathway regulation, STAT phosphorylation, B cell differentiation and germinal center formation, dendritic cell differentiation, neutrophil extravasation, and hypersensitivity. While one term references nervous system development, the dominant pattern is immune response and lymphoid activation, suggesting this cluster reflects general immune activation and signaling rather than a single specialized pathway.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0007399","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0042511","count":2},{"id":"GO:0002467","count":2}]},{"hash":"1411516667673675894","title":"Light-regulated flowering and signaling in plants","description":"The top GO terms cluster around light perception and signaling (red/far-red light, phototransduction, response to red light) and developmental control (positive regulation of flower development), with jasmonic acid signaling and regulatory processes suggesting a broader plant signaling module governing light-driven development and defense. This coherence supports labeling the cluster as a light-responsive flowering/signaling module in plants.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002805","count":2},{"id":"GO:0009867","count":2},{"id":"GO:0010218","count":2},{"id":"GO:0071158","count":2},{"id":"GO:2001178","count":2}]},{"hash":"2171359582454588930","title":"Unknown","description":"The GO terms are spread across diverse developmental contexts (placenta, wing cell fate, spermatid differentiation) and include protein processing, ER-associated proteolysis, unfolded protein response, oxidative stress response, and immune regulation. There isn't a coherent, single functional theme that ties most proteins together, so a specific label isn\u2019t justifiable.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":2},{"id":"GO:0042542","count":2},{"id":"GO:0016311","count":1},{"id":"GO:0009056","count":1},{"id":"GO:0035311","count":1}]},{"hash":"554584976151272157","title":"TLR Signaling and Cytokine Regulation","description":"The top GO terms are strongly centered on Toll-like receptor signaling (TLR8/10, MyD88-dependent) and related innate immune responses, including detection of bacterial lipopeptides, and regulation of cytokine production and interferon-beta. This points to a cohesive cluster of TLR-mediated innate immunity components, with some neuronal development terms (axon guidance/extension) appearing as secondary associations. Overall, the dominant theme is TLR-driven signaling and cytokine regulation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:0048681","count":2},{"id":"GO:0034166","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0034158","count":2}]},{"hash":"34951426362536781","title":"VEGF-Driven Endothelial Migration","description":"This cluster is dominated by GO terms related to endothelial cell migration and regulation of VEGF signaling, with additional hints of intracellular signal transduction and calcium signaling. Taken together, these annotations point to proteins involved in angiogenic signaling pathways that promote endothelial movement and vascular remodeling. Some transport terms are present but do not define the core function; the absence of edges suggests functional annotations span rather than indicate direct interactions. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":3},{"id":"GO:0043536","count":2},{"id":"GO:1900746","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0007205","count":2}]},{"hash":"1048035665081198028","title":"Kidney tubule and vascular morphogenesis","description":"The top GO terms cluster around metanephric tubule morphogenesis and lymph/vascular vessel morphogenesis, with additions on negative regulation of angiogenesis and VEGF signaling. This points to a shared theme of developmental tissue morphogenesis affecting kidney tubules and vascular structures, rather than a single, narrow pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072287","count":2},{"id":"GO:0072237","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0036303","count":2},{"id":"GO:0016525","count":2}]},{"hash":"1713430869851215144","title":"Glycinergic and monoaminergic neurotransmission","description":"The cluster is dominated by GO terms for glycinergic synaptic transmission and related glycine secretion, uptake, and regulation, as well as dopaminergic and serotonergic signaling (presentation includes dopamine uptake/catabolism and serotonin secretion). These points suggest a cohesive theme of CNS neurotransmitter signaling, with neural-development terms providing contextual background. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021984","count":5},{"id":"GO:0042066","count":5},{"id":"GO:0021794","count":5},{"id":"GO:0051583","count":5},{"id":"GO:1903346","count":5}]},{"hash":"994687475474990362","title":"Nuclear transcription and ribosome biogenesis","description":"The cluster\u2019s terms are dominated by DNA-templated transcription, transcription initiation, and DNA repair, alongside maturation and export steps for the large ribosomal subunit and preribosome assembly, indicating a shared role in nuclear gene expression control and ribosome maturation; a few outliers (sporulation, phenylacetate catabolic process) are less coherent with this theme but do not override the main signal.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0060355","count":2},{"id":"GO:0006367","count":1},{"id":"GO:0010124","count":1}]},{"hash":"1522873853129273398","title":"Ubiquitin-Proteasome Mediated Protein Degradation","description":"The dominant terms are ubiquitin-dependent protein catabolic processes and proteasome-mediated degradation, especially SCF-dependent ubiquitin ligation leading to proteasomal turnover. This suggests a cluster of proteins involved in tagging substrates for degradation and regulating protein levels. A few terms touch on circadian rhythm, stress responses to heavy metals, and cell-cycle related processes, which can be linked to ubiquitin-mediated control of metabolism, transcription, and division.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0031146","count":9},{"id":"GO:0021678","count":8},{"id":"GO:0000209","count":8},{"id":"GO:0042752","count":8}]},{"hash":"227313086734879520","title":"RNA Pol II Transcription Regulation","description":"Most of the top GO terms describe regulation of RNA polymerase II\u2013mediated transcription (DNA-templated transcription, positive regulation of transcription elongation by RNA Pol II, and preinitiation complex assembly). Although a few terms touch on DNA replication, Golgi retention, and growth factor signaling, the strongest signal in this cluster is transcriptional regulation by RNA Pol II, suggesting a module coordinating transcriptional output with cellular cues.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0045899","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0045053","count":2}]},{"hash":"314560008154271300","title":"Unknown","description":"The top terms span protein folding, cell cycle regulation, immune-related processes (MHC I antigen assembly, dendritic cell chemotaxis), reproductive interaction (sperm binding), signaling pathways, and development, with no single dominant function tying the proteins together. This suggests a heterogeneous mix rather than a coherent module.","confidence":"","size":17,"edges":63,"triangles":95,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006457","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0007339","count":1},{"id":"GO:0090398","count":1},{"id":"GO:2000510","count":1}]},{"hash":"164382200675910854","title":"Symbiont dormancy and stress response","description":"This cluster centers on dormancy signaling for a symbiont within a host and the plant-derived stress signaling that triggers it (e.g., cellular response to strigolactone), with subsidiary metabolic catabolic processes. ","confidence":"High","size":17,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":4},{"id":"GO:0006950","count":4},{"id":"GO:0019380","count":2},{"id":"GO:0006212","count":2},{"id":"GO:1902348","count":2}]},{"hash":"1884549166110093882","title":"RNA processing and translation initiation regulation","description":"The top GO terms cluster around post-transcriptional RNA processing (mRNA poly(A) tail regulation, splicing via the spliceosome, small-subunit processome assembly) and control of translation initiation (preinitiation complex formation, IRES-dependent initiation, and related processes). The combination suggests a coherent theme of coordinating gene expression at both mRNA maturation and the initiation of translation, with some terms referencing viral-like initiation mechanisms. This supports a label focused on RNA processing and translation initiation regulation.","confidence":"Medium","size":17,"edges":35,"triangles":37,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0060211","count":2},{"id":"GO:0006446","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0001731","count":2}]},{"hash":"279180113298785560","title":"Transmembrane Nutrient Transport and Osmotic Stress Response","description":"The cluster is dominated by GO terms for transmembrane transport of xenobiotics, vitamins, and sugars, plus phosphate and cation transport, along with cellular responses to glucose starvation and osmotic stress. This pattern points to membrane transport proteins coordinating uptake of nutrients (glucose, fructose, trehalose, vitamins, phosphate) and osmoregulation, rather than a single substrate class. The inclusion of insulin-stimulated glucose import further supports a theme of regulated nutrient uptake across membranes.","confidence":"High","size":17,"edges":21,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":15},{"id":"GO:0035461","count":15},{"id":"GO:0042149","count":14},{"id":"GO:1990539","count":14},{"id":"GO:0006970","count":14}]},{"hash":"2298835660606117973","title":"Calcium signaling and cardiovascular development","description":"The cluster centers on signaling changes, especially calcium release and phosphorylation, with several terms pointing to cardiovascular processes (heart development, blood coagulation, cell proliferation). While there is a visual perception/opsin signaling component, the recurring themes are calcium-mediated signaling and cardiovascular-related development, making this label a reasonable, cohesive characterization.","confidence":"Medium","size":17,"edges":33,"triangles":18,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0006468","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0022400","count":2},{"id":"GO:0051281","count":2}]},{"hash":"1250032497531259129","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0007507","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060586","count":3},{"id":"GO:0006398","count":3}]},{"hash":"1278625606385168347","title":"Metanephric kidney development","description":"This cluster is dominated by GO terms for metanephric and mesonephric duct morphogenesis and tubule development, indicating a renal development theme. A couple of immune/morphogenesis terms appear as peripheral context, but the core signal is kidney organogenesis and nephron/duct formation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":1},{"id":"GO:0072287","count":1},{"id":"GO:0010572","count":1},{"id":"GO:0072218","count":1},{"id":"GO:0090403","count":1}]},{"hash":"858346518454002675","title":"Transcription and RNA Processing","description":"The cluster's top GO terms center on transcriptional regulation by RNA polymerase II and DNA-templated transcription, with examples of RNA maturation (rRNA) and translation, suggesting a core theme of gene expression regulation and RNA processing. Additional terms such as ubiquitin-dependent protein catabolic process and mismatch repair indicate broader links to protein turnover and genome maintenance that commonly accompany expression-control machinery. Overall, the proteins seem grouped around transcriptional control and RNA processing with secondary roles in maintenance pathways.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006511","count":2}]},{"hash":"461183006562919528","title":"Ribosome Biogenesis and Translation","description":"This cluster is strongly associated with translation and ribosome biogenesis, including translation (GO:0006412), ribosome biogenesis (GO:0042254) and subunit biogenesis (GO:0042273, GO:1902626), as well as maturation of SSU/LSU rRNA (GO:0000462, GO:0000463) and small/large subunit assembly (GO:0000028, GO:0042254). These collectively indicate a cohesive ribosome-centered function; a few outlier terms (neural tube closure, viral mRNA export, single fertilization) are likely incidental annotations. Confidence: High","confidence":"","size":17,"edges":73,"triangles":167,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":6},{"id":"GO:0042273","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0000028","count":2}]},{"hash":"1982493573511845709","title":"Diverse solute membrane transporters","description":"The GO terms center on transmembrane transport across a variety of substrates (galactose, fructose, arabinose, sialic acid, phosphate, nitrate, potassium) and an osmotic stress response, indicating a cluster of membrane transporter proteins with broad substrate specificity and roles in nutrient uptake and osmoregulation. The lack of enzyme-specific terms and the repeated transport-related annotations support labeling this cluster as a group of solute transporters rather than catalytic proteins. Confidence is moderate because while transport is clear, the precise transporter family or mechanism may vary among members.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":2},{"id":"GO:0015757","count":2},{"id":"GO:1990539","count":2},{"id":"GO:0006970","count":2},{"id":"GO:0015751","count":2}]},{"hash":"1147863244610574803","title":"Ribosome Biogenesis and Cell Cycle","description":"Most terms cluster around ribosome assembly (ribosome biogenesis, small/large subunit export), tRNA modification, and cell cycle processes (cell division, septum assembly). While a single term about cellular fusion appears, the dominant signal is production of ribosomes and progression through the cell cycle, with supporting stress-response regulation. This supports a cohesive label focused on ribosome biogenesis intertwined with cell-cycle progression.","confidence":"High","size":17,"edges":13,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000747","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0042274","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0006400","count":6}]},{"hash":"796957194474791015","title":"Neuronal development and synaptic signaling","description":"This cluster shows enrichment for brain development (GO:0007420) and regulation of synaptic vesicle exocytosis (GO:2000300), plus negative regulation of short-term neuronal synaptic plasticity, indicating a common theme of neuronal development and synaptic function. A few terms related to cell cycle or intracellular transport appear but are less central, so the primary signal is neural development and synaptic regulation.","confidence":"Medium","size":17,"edges":84,"triangles":157,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010796","count":4},{"id":"GO:0007420","count":4},{"id":"GO:2000300","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0035023","count":3}]},{"hash":"755363909375624795","title":"Neural Development and Synaptic Signaling Regulation","description":"The GO terms cluster around neural development and synaptic plasticity (positive regulation of neuron projection development; long-term synaptic potentiation), with supporting regulatory signaling (GTPase activity) and a few vascular/renal terms that are less dominant; overall the dominant theme appears to be neural development and synaptic signaling regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0070433","count":2},{"id":"GO:0043547","count":2}]},{"hash":"704101150533995016","title":"Redox Homeostasis and Oxidative Stress Response","description":"The cluster is dominated by GO terms for maintaining redox balance and responding to oxidative stress (cell redox homeostasis, cellular oxidant detoxification, cellular response to oxidative stress, protein deglutathionylation). These core terms suggest a group of proteins involved in managing reactive species and redox state. A few terms touch on nucleotide biosynthesis or transcription regulation, and one developmental term may be incidental; however, the prevailing pattern points to redox regulation and detoxification as the cluster\u2019s main theme.","confidence":"High","size":17,"edges":127,"triangles":565,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":7},{"id":"GO:0098869","count":7},{"id":"GO:0030416","count":5},{"id":"GO:0055114","count":5},{"id":"GO:1903026","count":4}]},{"hash":"1167781367564020500","title":"Embryonic development and tissue morphogenesis","description":"This cluster contains GO terms spanning nervous system development (myelination, synapse organization) as well as tissue morphogenesis across multiple tissues (cartilage, hair follicles, palate) and broader embryonic development (endocrine system, left-right patterning, placenta-related regulation), suggesting a cohesive theme of developmental processes shaping diverse tissues during embryogenesis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0060707","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060021","count":1}]},{"hash":"297869310270332788","title":"Unknown","description":"The terms span transcription, cytoskeleton/microtubule dynamics, vesicle transport, ubiquitination, and T cell signaling, with no clear single theme tying them together. The empty edge structure also suggests no cohesive interaction pattern. Therefore there isn\u2019t a specific, representative label beyond Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0072321","count":1},{"id":"GO:0050862","count":1},{"id":"GO:0090063","count":1},{"id":"GO:0048491","count":1}]},{"hash":"1343973954714290518","title":"Unknown","description":"The set of GO terms spans RNA splicing, protein ubiquitination/degradation, signaling, apoptosis, and cytoskeletal assembly (septin ring), with no single cohesive function tying the proteins together, so a concise, representative label cannot be assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":1},{"id":"GO:1903265","count":1},{"id":"GO:1903762","count":1},{"id":"GO:0051865","count":1},{"id":"GO:0046328","count":1}]},{"hash":"1553975882872713265","title":"Developmental transcriptional regulation","description":"Top terms indicate strong involvement in transcriptional control by RNA polymerase II (including negative regulation and regulation of DNA-templated transcription) alongside diverse development-related processes (pituitary gland, midbrain, eye, cerebral cortex interneuron differentiation, spinal cord oligodendrocyte fate, and lung morphogenesis). This points to proteins that coordinate transcription during development, with a neural development emphasis but not exclusively neural. ","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0006366","count":6},{"id":"GO:0006355","count":6},{"id":"GO:0051216","count":5}]},{"hash":"622549981572492162","title":"Glutamatergic synaptic signaling and memory","description":"The top GO terms are dominated by neuronal functions: excitatory postsynaptic potential, glutamatergic synaptic transmission, calcium ion transport, and long-term memory, with additional signals related to neurotransmission and amphetamine response. While a few terms touch on development or signaling regulation, the strongest, most frequent signals point to glutamatergic synapse function and memory processes, making this an intuitive core theme for the cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0006469","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0001707","count":3},{"id":"GO:1901621","count":3}]},{"hash":"1632348787777411110","title":"Skeletal and striated muscle differentiation","description":"The cluster\u2019s top GO terms are dominated by muscle differentiation (myoblast, skeletal, and striated muscle differentiation) with a supporting note on tissue homeostasis; Notch pathway terms are present but far less represented, suggesting the primary theme is muscle cell development rather than signaling per se.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":2},{"id":"GO:0007219","count":1},{"id":"GO:0051168","count":1},{"id":"GO:0045746","count":1},{"id":"GO:0045445","count":1}]},{"hash":"2293614292912594756","title":"Proteostasis and signaling components","description":"The cluster centers on protein turnover and synthesis (ubiquitin-dependent ERAD, proteasome assembly, translation) and also includes signaling- and development-related terms (TGF-beta response, innate immunity, heart development, long-term potentiation). This points to proteins involved in maintaining proteome homeostasis while modulating signaling pathways across developmental and immune contexts.","confidence":"Medium","size":17,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0070682","count":2},{"id":"GO:0071560","count":2}]},{"hash":"893812473120190897","title":"Neurodevelopment and TGF-beta signaling","description":"This cluster features neural development terms (forebrain development, neural tube closure) and a cellular response to transforming growth factor beta stimulus, along with related signaling and transcriptional regulation terms, indicating proteins involved in vertebrate neurodevelopment and associated signaling cascades.","confidence":"High","size":17,"edges":36,"triangles":27,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071560","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0001843","count":4}]},{"hash":"1300758440490828525","title":"Microglial TLR-MyD88 innate immune activation","description":"This cluster is dominated by GO terms for microglial cell activation and Toll-like receptor signaling (including TLR8 and TLR10) with MyD88 dependency, alongside downstream cytokine responses (interferon-beta, Th1 differentiation, IL-5, IL-17). The cohesive theme is microglial sensing of microbial components via TLRs and mounting innate immune responses with cytokine production, suggesting a microglia-centered innate immune module.","confidence":"High","size":17,"edges":10,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001774","count":13},{"id":"GO:0034166","count":13},{"id":"GO:0034158","count":13},{"id":"GO:0002755","count":13},{"id":"GO:0045359","count":13}]},{"hash":"1712626591185853118","title":"Embryonic organogenesis and neural-sensory development","description":"The top GO terms cluster around development of multiple organs (face/craniofacial skeleton, heart, retina) and neural/sensory systems (neuron migration, motor neuron differentiation, visual perception), indicating a cohesive vertebrate embryonic development program that spans organogenesis and neural-sensory differentiation.","confidence":"High","size":17,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":10},{"id":"GO:0048701","count":10},{"id":"GO:0007601","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0003350","count":10}]},{"hash":"1111869840868734683","title":"Ubiquitin-dependent proteolysis","description":"This cluster is strongly enriched for ubiquitin-related processes, including ubiquitin-dependent protein catabolic process, autoubiquitination, and K6-linked ubiquitination, with additional links to histone ubiquitination and related regulatory pathways. The common thread is ubiquitin-mediated protein turnover and regulation, making this an intuitive label for the protein group.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0051865","count":8},{"id":"GO:1903265","count":7},{"id":"GO:0085020","count":7},{"id":"GO:0036205","count":7}]},{"hash":"1849690337746898800","title":"Ribosome Biogenesis and Translation Initiation","description":"Based on the top GO terms, the cluster centers on ribosome biogenesis and translation initiation: maturation of LSU-rRNA, ITS1 processing to separate rRNA, and formation of the translation preinitiation complex. While other terms point to development and signaling (multicellular growth, neural tube closure, hypoxia response, TGF-beta), these likely reflect broader regulatory contexts rather than a single non-ribosomal function. The strongest common theme is components and steps involved in ribosome assembly and initiation of protein synthesis, supporting this label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0035264","count":9},{"id":"GO:0010659","count":7},{"id":"GO:0071456","count":7},{"id":"GO:0000463","count":7},{"id":"GO:0071560","count":7}]},{"hash":"1487963768251790957","title":"Embryonic development and organ differentiation","description":"The top GO terms cluster around developmental processes across multiple tissues and stages, including primitive streak formation, pituitary and gonad development, heart morphogenesis, neuro- and myeloid lineage differentiation, and erythrocyte/granulocyte differentiation, indicating a cohesive theme of embryonic development and tissue differentiation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0045648","count":7},{"id":"GO:0090009","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0048935","count":6}]},{"hash":"1199455904000818645","title":"Extrinsic Apoptosis and Complement Activation","description":"This cluster centers on GO terms about regulating extrinsic apoptotic signaling, activation-induced T cell death, and both classical and alternative complement activation (including MAC activation). These immune-related processes strongly connect to apoptosis and the complement system, suggesting a coherent functional theme despite some developmental terms present. ","confidence":"High","size":17,"edges":30,"triangles":15,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":4},{"id":"GO:0006924","count":4},{"id":"GO:0001970","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0006957","count":3}]},{"hash":"739589481930499122","title":"Heart and kidney organogenesis with cell adhesion","description":"Most top GO terms point to developmental processes for organs (heart development, kidney development, glomerular capillary formation) and cell-cell adhesion, suggesting a morphogenesis-focused cluster centered on organ formation and tissue cohesion. Rho signaling regulation and related cytoskeletal cues align with morphogenic cell movements, while occasional neuronal/dendritic spine terms appear as broader cytoskeletal regulation signals. Overall, the cluster seems to represent organogenesis with emphasis on heart and kidney development and adhesion between cells. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0097194","count":2}]},{"hash":"1127814501764191564","title":"Neural development and axon guidance","description":"Most terms point to nervous system development and axon guidance (corticospinal tract morphogenesis, dopaminergic neuron axon guidance, sensory perception of sound, synaptic vesicle clustering). A few terms touch on heart-related development, but the dominant signal is neural development and neural connectivity. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086073","count":1},{"id":"GO:0021957","count":1},{"id":"GO:0003273","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0036514","count":1}]},{"hash":"1794726477542157328","title":"Endothelial Adhesion and Sprouting Angiogenesis","description":"The top GO terms point to heterophilic cell-cell adhesion and cell-matrix adhesion, along with endothelial cell proliferation, chemotaxis, and sprouting angiogenesis, all within inflammatory and developmental contexts. This suggests a cohesive role in endothelial adhesion processes driving angiogenic sprouting under inflammatory/developmental cues.","confidence":"High","size":17,"edges":39,"triangles":17,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":11},{"id":"GO:0007275","count":11},{"id":"GO:0032496","count":10},{"id":"GO:0071260","count":10},{"id":"GO:0007160","count":10}]},{"hash":"2068698448550967421","title":"RNA Methylation and Modification","description":"The cluster is dominated by GO terms for RNA methylation and related RNA modification steps\u2014tRNA methylation, wobble uridine modification, mRNA capping, guanine-N7 methylation, and rRNA modification\u2014indicating a cohesive set of proteins involved in RNA processing/modification rather than a single metabolic pathway. Co-occurring terms like cellular growth and senescence may reflect cellular states rather than core function.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030488","count":6},{"id":"GO:0002098","count":6},{"id":"GO:0006370","count":6},{"id":"GO:0090398","count":6},{"id":"GO:0000154","count":6}]},{"hash":"2134127523217329328","title":"Immune response and vascular remodeling","description":"The top GO terms point to innate immune activation (complement pathway, response to lipopolysaccharide, leukocyte migration) together with vascular-related processes (angiogenesis, fibrinolysis, plasminogen activation). Although a couple of outlier terms (midbrain development, transcriptional regulation) are present, the dominant signal links immune/inflammatory responses to remodeling of the vasculature.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0030901","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1598846157373736284","title":"Ubiquitin-Dependent Innate Immunity","description":"The cluster is enriched for ubiquitination-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, polyubiquitination, K6-linked ubiquitination) together with innate immune defense terms (innate immune response, defense response to virus) and NF-kB signaling, indicating a cohesive role in ubiquitin-mediated regulation of antiviral immune signaling and protein turnover.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0045087","count":8},{"id":"GO:0051607","count":8},{"id":"GO:1903265","count":7},{"id":"GO:0051865","count":7}]},{"hash":"1966673198998863225","title":"Neuronal ion channels and synaptic transmission","description":"This cluster centers on neuronal signaling: ion transport (potassium, sodium) across membranes, various synaptic transmissions (glycinergic, GABA), and excitatory postsynaptic potentials, with themes of sensory processing (sound perception, vestibulocochlear development) and behavior. The converging GO terms point to neural excitability and communication, especially in auditory and related behavioral pathways.","confidence":"High","size":17,"edges":50,"triangles":46,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":16},{"id":"GO:0007626","count":16},{"id":"GO:0060079","count":16},{"id":"GO:0001661","count":16},{"id":"GO:0035725","count":16}]},{"hash":"2218302948833261277","title":"Developmental organogenesis and cell adhesion","description":"The top GO terms converge on development across multiple organs (kidney, salivary gland, nervous system) and processes tied to cell-cell adhesion (including homophilic adhesion), suggesting the proteins function in tissue morphogenesis and organ formation rather than a single, narrow pathway. The absence of edges supports a more varied developmental role rather than a tight interaction module.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001200","count":4},{"id":"GO:0045214","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0016337","count":3},{"id":"GO:0061000","count":3}]},{"hash":"891075541185515438","title":"Cardiac Development and Electrical Activity","description":"This cluster centers on heart formation and function: regulation of atrial and SA node action potentials, left ventricular and outflow tract morphogenesis, and calcium release from the sarcoplasmic reticulum, all pointing to cardiac development and excitation-contraction coupling. Some terms like skin development or ossification appear incidental, but the dominant signal is cardiac morphology and electrical activity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098910","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0014808","count":4},{"id":"GO:0003151","count":3}]},{"hash":"939123929878867967","title":"Neural Development and Signaling","description":"These terms cluster around neural differentiation and signaling (axonogenesis, visual perception, excitatory postsynaptic potential) while also including vascular/heart development (VEGF pathway, heart development) and general cell signaling and cycle control (mitotic processes, apoptosis). The common theme appears to be proteins coordinating developmental signaling with a neural emphasis, so Neural Development and Signaling seems representative. ","confidence":"Medium","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030948","count":13},{"id":"GO:0007409","count":11},{"id":"GO:0009738","count":11},{"id":"GO:0043065","count":11},{"id":"GO:0010800","count":11}]},{"hash":"1075822901145556839","title":"Immune cell adhesion and extravasation","description":"This cluster is enriched for GO terms related to immune signaling and cell adhesion, including integrin-mediated signaling, heterotypic cell-cell adhesion, cellular extravasation, and T cell activation. Coagulation appears among terms, tying immune adhesion to inflammatory processes and ECM interactions, together pointing to leukocyte adhesion/migration through the vascular wall and surrounding matrix.","confidence":"High","size":16,"edges":110,"triangles":440,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0002291","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0031104","count":3},{"id":"GO:0034113","count":3}]},{"hash":"1042170795153237456","title":"Unknown","description":"The top GO terms point to several unrelated processes (cell cycle, autophagy/ubiquitination, TLR/MyD88 signaling, neuronal migration, dopamine signaling, and organ size regulation), with no clear shared function across all proteins. This suggests a heterogeneous cluster rather than a single pathway, so Unknown is the appropriate label.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0016239","count":2},{"id":"GO:0002755","count":2},{"id":"GO:0035564","count":2},{"id":"GO:0060161","count":2}]},{"hash":"196881126100475843","title":"Innate Immunity and Coagulation","description":"The top GO terms reveal a clear immune-focused theme: defense response to Gram-positive bacteria, immune response, and complement activation via the lectin pathway, alongside blood coagulation. These points strongly to innate immune defense and coagulation processes. A couple of terms relate to RNA processing and protein complex assembly, which are less central here, but do not overshadow the dominant immune/coagulation signal.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0070208","count":2}]},{"hash":"109014903881772146","title":"Cardiovascular GPCR signaling and immune regulation","description":"This cluster is dominated by terms connecting GPCR signaling (adenylate cyclase-inhibiting dopamine receptor signaling, GPCR pathway regulation, prostaglandin response), cardiovascular processes (renin-angiotensin\u2013regulated blood pressure, vascular smooth muscle differentiation, acetylcholine metabolism), and immune/inflammatory responses (immune response, IL-1\u03b2 production, cytolysis). Together they point to signaling networks that govern vascular function and immune modulation, hence a cardiovascular GPCR signaling and immune regulation cluster.","confidence":"High","size":16,"edges":14,"triangles":0,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":14},{"id":"GO:0007195","count":14},{"id":"GO:0060408","count":14},{"id":"GO:0007497","count":14},{"id":"GO:0006955","count":14}]},{"hash":"927955526806496122","title":"Neural excitability and synaptic signaling","description":"The top GO terms cluster around neural signaling: membrane depolarization and excitatory postsynaptic potentials, sodium/potassium ion transport, and glycinergic/GABAergic synapses, along with sensory processes like sound perception. This points to a module of neuronal excitability and synaptic transmission involved in auditory and general sensory signaling.","confidence":"High","size":16,"edges":115,"triangles":495,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":16},{"id":"GO:0051899","count":15},{"id":"GO:0071805","count":15},{"id":"GO:0035725","count":15},{"id":"GO:0050910","count":14}]},{"hash":"198731311652217823","title":"Ethanol and Lipid Metabolism with Redox","description":"The cluster shows strong representation of ethanol-related processes (ethanol catabolic/oxidation, pyruvate fermentation to ethanol), along with lipid metabolism topics (retinol metabolism, prostaglandin metabolism, fatty acid biosynthesis) and redox-associated terms (oxidation/NADH). This points to a cohesive theme around alcohol handling and lipid biosynthesis with energy-redox steps, despite some obsolete GO entries. ","confidence":"Medium","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006069","count":10},{"id":"GO:0006068","count":10},{"id":"GO:0042572","count":10},{"id":"GO:0055114","count":10},{"id":"GO:0006633","count":8}]},{"hash":"269187921158105231","title":"Regulation of signaling and protein turnover","description":"This cluster is characterized by terms pointing to modulation of signaling pathways (JNK cascade, GTPase activity, TNF signaling, GABAergic transmission) and ubiquitin-dependent processes (autoubiquitination, protein catabolic process), suggesting proteins that regulate signaling networks and protein stability rather than a single function. The dosage compensation term appears incidental. ","confidence":"High","size":16,"edges":15,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009048","count":3},{"id":"GO:0040009","count":2},{"id":"GO:0032228","count":2},{"id":"GO:0048147","count":2},{"id":"GO:0043547","count":2}]},{"hash":"341443470398556935","title":"DNA damage-induced apoptosis with inflammatory signaling","description":"The cluster combines strong signals of DNA damage response (p53-mediated, cell cycle arrest) with both intrinsic and extrinsic apoptotic pathways, plus inflammatory cytokine production (IL-8, IL-1, IL-17) and LPS/T cell receptor signaling, suggesting a set of proteins involved in stress-induced apoptosis coupled with immune/inflammatory responses.","confidence":"Medium","size":16,"edges":17,"triangles":2,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006977","count":3},{"id":"GO:0032757","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0050852","count":2}]},{"hash":"675222761419494991","title":"GPCR-Mediated Blood Pressure Regulation","description":"The top GO terms cluster around regulation of arterial blood pressure via renin-angiotensin, dopamine receptor signaling, acetylcholine metabolism, prostaglandin response, and general GPCR signaling, suggesting a cohesive theme of GPCR-driven cardiovascular/neuroendocrine regulation. Outlier terms like posterior midgut development and immune response are present but do not override the core signal. Confidence that this label captures the cluster\u2019s function is high.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":9},{"id":"GO:0007195","count":9},{"id":"GO:0060408","count":9},{"id":"GO:0007497","count":9},{"id":"GO:0006955","count":9}]},{"hash":"467272912647884548","title":"Calcium-Dependent Signaling and Metabolic Regulation","description":"The cluster features terms centered on calcium release into the cytosol and GPCR signaling, coupled with energy/metabolic processes (electron transport chain, thermogenesis) and systemic responses (blood pressure regulation, coagulation) as well as sensory processes (phototransduction, pain, temperature). This points to a theme of calcium-mediated signaling linked to metabolic and systemic regulation, albeit across diverse physiological contexts.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":11},{"id":"GO:0002024","count":11},{"id":"GO:0007603","count":11},{"id":"GO:0051281","count":11},{"id":"GO:0010579","count":11}]},{"hash":"1460347109934240470","title":"Cardiovascular GPCR-cAMP Signaling","description":"The top GO terms cluster around GPCR signaling that activates or inhibits adenylate cyclase and downstream cAMP pathways, with connections to blood pressure regulation (positive regulation of blood pressure, renin-angiotensin system) and related signaling (dopamine and acetylcholine receptor pathways). While some terms like electron transport and immune response appear, the dominant theme is GPCR-cAMP signaling linked to cardiovascular regulation, suggesting the proteins function in modulating vascular signaling and pressure. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0007190","count":9},{"id":"GO:0035025","count":9}]},{"hash":"1545250453159957094","title":"Cardiovascular GPCR Signaling","description":"The cluster is dominated by GO terms for GPCR signaling and cardiovascular regulation, including positive regulation of blood pressure, adenylate cyclase-activating GPCR pathways, dopamine receptor signaling, and acetylcholine metabolism. This points to GPCR-driven control of vascular tone and cardiac signaling as the core theme, with additional terms relating to energy metabolism and development as broader context. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":11},{"id":"GO:0010579","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0001991","count":10},{"id":"GO:0007195","count":10}]},{"hash":"1813394697253217165","title":"Unknown","description":"The GO terms are highly diverse (development in pituitary and cartilage, various transport and immune functions, xenobiotic and LPS responses) with no single shared pathway or function evident among the proteins. The absence of edges and a coherent theme supports labeling Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0042391","count":2},{"id":"GO:0032496","count":2}]},{"hash":"2080263687391546458","title":"Unknown","description":"The GO terms span RNA splicing, DNA integration and proviral latency, host apoptosis activation in symbiotic contexts, muscle cell migration, actin cytoskeleton remodeling, transcriptional regulation, and various developmental processes (trophoblast differentiation, placenta development, cartilage morphogenesis). There is no clear, single functional theme linking these proteins, so a cohesive, high-level label is not apparent.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0014839","count":2}]},{"hash":"1540681888024713534","title":"Unknown","description":"The top GO terms span neural behavior, MAPK signaling, spermatid development, cell cycle, vesicle transport, exosomal secretion, bone ossification, keratinization, and GABAergic synaptic transmission, with no clear single pathway or function tying them together. This broad mix lacks a cohesive, representative theme for the cluster, so no confident label can be assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035641","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0007286","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0006890","count":4}]},{"hash":"2007501123287066550","title":"Vesicle trafficking and exocytosis","description":"Proteins in this group cluster around vesicle cycling: calcium-dependent exocytosis, endocytosis regulation, and vesicle transport (including clathrin-mediated endocytosis and synaptic vesicle coating). The combination of exocytosis and endocytosis terms with transport and cytoskeletal signaling (Rho) supports a cohesive vesicle trafficking theme, with some signaling-related terms offering broader context. Confidence: Medium","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":2},{"id":"GO:0045806","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0050715","count":2},{"id":"GO:0019933","count":2}]},{"hash":"28096841122320133","title":"RNA processing and mRNA stability under stress","description":"The top GO terms cluster around RNA metabolism: mRNA splicing (including alternative splicing), mRNA decay and catabolic processes, regulation of mRNA stability in response to stress, and mitochondrial mRNA polyadenylation. Together these indicate a cohesive function in RNA processing, maturation, and turnover under stress conditions, justifying a single, specific label for the cluster.","confidence":"High","size":16,"edges":15,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":3},{"id":"GO:0070478","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0033129","count":2},{"id":"GO:0097222","count":2}]},{"hash":"1188155415228179959","title":"mRNA processing and translation initiation control","description":"The cluster centers on RNA maturation and translation initiation regulation, with GO terms for mRNA splicing (spliceosome), polyadenylation and poly(A) tail regulation, and steps of translation initiation (preinitiation complex formation, regulation of initiation, reinitiation, and IRES-dependent translation). This suggests a cohesive theme linking RNA processing to translational control.","confidence":"High","size":16,"edges":30,"triangles":23,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":11},{"id":"GO:0045292","count":10},{"id":"GO:0001731","count":9},{"id":"GO:0002188","count":9},{"id":"GO:0060211","count":8}]},{"hash":"452971811885966083","title":"Cell adhesion and tissue morphogenesis","description":"This cluster centers on GO terms related to cell adhesion (cell-cell adhesion; homophilic/heterophilic adhesion; cell-cell junction organization) and tissue morphogenesis (endothelial barrier establishment; ossification; endocardial cushion migration; corticospinal tract morphogenesis; apical protein localization), spanning neural, cardiac, vascular, and skeletal contexts. The presence of one outlier term (marginal zone B cell differentiation) suggests some heterogeneity, but the common theme is adhesion-driven tissue organization. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045176","count":4},{"id":"GO:0002315","count":4},{"id":"GO:1903142","count":4},{"id":"GO:0021957","count":4},{"id":"GO:0007157","count":4}]},{"hash":"1227006276599204481","title":"Axon guidance and neural signaling","description":"These terms cluster around nervous system development, axon guidance (Roundabout), ERK/MAPK signaling, and GABAergic synaptic transmission, indicating a group of proteins involved in neural development and synaptic signaling. Ribosomal export terms are incidental.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0070374","count":3}]},{"hash":"1902340255664847005","title":"Vertebrate Development and Neural Assembly","description":"The strongest terms cluster around vertebrate development and neural formation, including multicellular organism development, skeletal system development, neural tube closure, and positive regulation of synapse assembly, suggesting a group of proteins involved in developmental and neural connectivity processes. Some terms are unrelated (radiation response, defense, translational processes), but the core signal points to developmental and neural roles.","confidence":"Medium","size":16,"edges":47,"triangles":36,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071479","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0051965","count":3}]},{"hash":"959747764983798934","title":"Cellular responses to diverse stimuli","description":"The GO terms point to responses to lipopolysaccharide, mechanical stimuli, muscle stretch, pain, TNF signaling, and other cues, plus calcium signaling and morphogenesis. This suggests a broad collection of stimulus-response and signaling processes rather than a single specific function, so a concise label \"Cellular responses to diverse stimuli\" captures the cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0048148","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0051281","count":3}]},{"hash":"966823419995873355","title":"Proteostasis and Protein Turnover","description":"The cluster is dominated by proteasome-related terms (proteasome regulatory particle assembly; proteasomal protein catabolic process; positive regulation of proteasomal protein catabolic process) and protein unfolding, pointing to protein quality control and turnover as the central theme. Some vesicle transport and oxidative phosphorylation terms appear, but the strongest signal centers on proteostasis.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071712","count":7},{"id":"GO:0070682","count":7},{"id":"GO:0051260","count":7},{"id":"GO:0072389","count":6},{"id":"GO:1901800","count":6}]},{"hash":"236852296481417847","title":"Immune signaling with calcium and cGMP regulation","description":"The cluster is dominated by immune-related GO terms (T cell receptor signaling, neutrophil chemotaxis, interferon production, macrophage CSF stimulus), suggesting a core function in immune signaling. Additional terms point to intracellular signaling modulation via calcium release and cGMP metabolic processes, indicating coordinated signaling dynamics. A few terms (retinal cone development, lipid catabolic regulation) appear peripheral. Overall, the proteins likely participate in immune signaling with concurrent regulation of calcium- and cGMP-mediated pathways.","confidence":"Medium","size":16,"edges":31,"triangles":9,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0010753","count":4},{"id":"GO:0036006","count":4},{"id":"GO:0032729","count":4},{"id":"GO:0046069","count":4}]},{"hash":"461824533379377342","title":"Unknown","description":"These terms span nitrogen metabolism (nitrate assimilation), immune/stress responses (response to lipopolysaccharide, response to ethanol, nitric oxide biosynthesis), organellar inheritance and development (mitochondrion inheritance, myelin maintenance, sebaceous gland differentiation), and fungal lipid pathways (MIPC metabolism, ergosterol biosynthesis regulation, unsaturated fatty acid biosynthesis). There is no single cohesive biological process that links all of these terms, making a confident, unified label inappropriate.","confidence":"","size":16,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0032496","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0006675","count":2}]},{"hash":"1685341177311559248","title":"Fungal cell wall biosynthesis and ER stress response","description":"The cluster is dominated by the fungal-type beta-glucan biosynthetic term, which strongly indicates a focus on fungal cell wall construction. Additional terms highlight secretory pathway activity (protein targeting to membranes, SRP-dependent translocation) and ER-related stress responses (unfolded protein response, ER stress-induced signaling), suggesting a cohesive theme around cell wall biosynthesis in fungi and related protein quality control processes. Medium","confidence":"","size":16,"edges":105,"triangles":455,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070880","count":15},{"id":"GO:0006880","count":15},{"id":"GO:1903751","count":15},{"id":"GO:0006260","count":15},{"id":"GO:0016226","count":15}]},{"hash":"2050620900434616463","title":"Vertebrate CNS development and patterning","description":"Based on the GO terms, the cluster centers on transcriptional regulation during embryonic development with a strong emphasis on neural tube patterning and neural differentiation (floor plate development, spinal cord interneuron differentiation, amacrine cell differentiation, oligodendrocyte fate) alongside somitogenesis. While there are also broader organ morphogenesis terms (lung vasculature, pulmonary valve), the dominant signal is vertebrate neural development and patterning.","confidence":"High","size":16,"edges":117,"triangles":521,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0001756","count":9},{"id":"GO:0060426","count":9},{"id":"GO:0035881","count":9},{"id":"GO:0033504","count":9}]},{"hash":"545979629058192719","title":"Embryonic morphogenesis and adhesion with inflammatory signaling","description":"This cluster centers on embryonic development processes (osteoblast development, neural crest formation, digit morphogenesis) and cell-matrix adhesion, suggesting roles in tissue formation and remodeling. The presence of innate immune response and cytokine production terms indicates inflammatory signaling associated with development or tissue homeostasis. Additional terms point to broader regulatory and physiological roles (transcriptional regulation, renal sodium handling, blood pressure), which may reflect pleiotropic functions in developing organs. Overall, a cohesive label is embryonic morphogenesis and adhesion with inflammatory signaling.","confidence":"Medium","size":16,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002076","count":4},{"id":"GO:0014029","count":4},{"id":"GO:0042733","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0045087","count":4}]},{"hash":"1407362996143410551","title":"Mitochondrial Calcium Handling and Metabolism","description":"The dominant GO terms point to mitochondrial calcium import and regulation, combined with carbohydrate and fatty acid metabolic processes, implying a cohesive theme of mitochondrial energy metabolism coupled to calcium signaling. Although there are no network edges, the enrichment suggests a functional module focused on mitochondrial metabolism and calcium homeostasis rather than a single physical pathway. Heart development and some niche biosynthetic terms appear less central to the core theme, likely reflecting broader annotations.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0036444","count":2},{"id":"GO:0051561","count":2},{"id":"GO:1904070","count":1}]},{"hash":"1500016690495943836","title":"Endothelial and Renal Signaling Regulation","description":"The terms cluster around vascular signaling control (negative regulation of VEGF receptor signaling and ERK cascade) and kidney/epithelial processes (aldosterone secretion, podocyte development, blood pressure regulation). A few metabolic terms (cholesterol efflux, gluconeogenesis) suggest broader homeostatic roles; overall they point to a module of endothelial-renal signaling regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":4},{"id":"GO:0045715","count":3},{"id":"GO:0070373","count":3},{"id":"GO:0045776","count":3},{"id":"GO:0050673","count":3}]},{"hash":"1302905874740262749","title":"Cardiac and Vascular Signaling and Remodeling","description":"The top GO terms cluster around calcium-regulated cardiac muscle signaling, contraction, and hypertrophy responses, with additional terms tied to vascular branching and signaling pathways. This pattern suggests a group of proteins involved in heart muscle function and remodeling, potentially coupled with vascular development and related signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007018","count":2},{"id":"GO:0061026","count":2},{"id":"GO:0051531","count":1},{"id":"GO:0010800","count":1},{"id":"GO:1903244","count":1}]},{"hash":"1294399175391081943","title":"Mesodermal organogenesis and vascular development","description":"These proteins cluster around organ formation and vascular development in mesoderm-derived tissues, with strong signals for cardiac vascular smooth muscle development, pulmonary valve and lung differentiation, and kidney glomerular/vasculature formation, plus somite development. The set points to coordinated development of heart, lung, and kidney vasculature rather than a single metabolic or regulatory pathway.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0045821","count":16},{"id":"GO:0001756","count":16},{"id":"GO:0043433","count":16},{"id":"GO:0060948","count":16},{"id":"GO:0072141","count":16}]},{"hash":"1596850787883617273","title":"Hormone-responsive metabolic signaling genes","description":"This cluster shows GO terms tied to hormonal signaling (glucagon, glucocorticoid, cAMP) and metabolic/physiological responses (amino acids, lactation, muscle growth regulation, ethanol response), suggesting a set of proteins involved in endocrine signaling and metabolic adaptation rather than a single pathway. The presence of obsolete terms and no network edges further indicates broad regulatory roles rather than direct physical interactions in this dataset.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0048633","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0033762","count":2},{"id":"GO:0019452","count":2}]},{"hash":"606604796195643510","title":"Unknown","description":"The top GO terms are mutually diverse (fatty acid metabolism, ectoine biosynthesis/catabolism, a fungal toxin biosynthetic process, and neuronal and bone remodeling terms), and with no connectivity (edges or triangles) these proteins do not form a cohesive functional module. Therefore a single, descriptive label cannot be confidently assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0001561","count":2},{"id":"GO:0097089","count":2},{"id":"GO:0042400","count":2},{"id":"GO:1902181","count":2}]},{"hash":"1814097753748800196","title":"Metanephric kidney development","description":"The Top Terms are dominated by metanephric nephron and tubule morphogenesis terms (proximal/distal tubules, ascending limb, mesonephric duct development), with a couple of inflammatory signals as less-represented outliers. This points to a cluster centered on metanephric kidney development rather than a general immune/process cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":2},{"id":"GO:0036303","count":1},{"id":"GO:0072287","count":1},{"id":"GO:0010572","count":1},{"id":"GO:0072218","count":1}]},{"hash":"1852369207544504998","title":"Organ Development and Hormone Signaling","description":"The cluster features several development- and organ-function related terms, including endodermal differentiation, camera-type eye morphogenesis, metanephric podocyte development, and renal albumin absorption, as well as aldosterone secretion and cAMP-PKA signaling. While there are immune-related terms (complement activation, granulocyte differentiation, PDGFR signaling), the dominant pattern points to organ development and hormonal regulation rather than a single specific pathway. ","confidence":"Medium","size":16,"edges":40,"triangles":5,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045715","count":4},{"id":"GO:2000860","count":4},{"id":"GO:2000478","count":4},{"id":"GO:0030853","count":4},{"id":"GO:0006958","count":4}]},{"hash":"578466612858520135","title":"Diverse Metabolic Processes","description":"The top GO terms indicate a mix of catabolic and biosynthetic metabolism (lipids, nucleotides, phenylpropanoids, biotin, antibiotics) plus detoxification and regulatory pathways, with no single shared pathway tying all proteins together. This suggests broad metabolic versatility rather than a specific function module, so a broad label like this best fits without over-committing.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":8},{"id":"GO:0098869","count":8},{"id":"GO:0017000","count":8},{"id":"GO:2000124","count":8},{"id":"GO:0009102","count":8}]},{"hash":"12087419370288487","title":"Kinase and GTPase signaling regulation","description":"The cluster is enriched for terms about regulating kinase and GTPase activities (e.g., positive regulation of GTPase activity, negative regulation of protein tyrosine kinase activity, and positive regulation of serine/threonine kinase activity) and includes signaling-related responses such as TGF-beta stimulus and hypoxia, suggesting a focus on modulating signal transduction. Some terms such as histone acetylation and mRNA transport appear peripheral or obsolete, but the core theme remains signaling pathway regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0071560","count":4},{"id":"GO:0061099","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0098907","count":4}]},{"hash":"1334026753526554755","title":"Cardiac development and signaling","description":"Based on the top GO terms, the cluster is centered on heart biology: heart development, SA node action potential regulation, and cardiac muscle hypertrophy in response to stress, plus regulation of protein kinase activity, which ties into cardiac signaling pathways. While a few terms (e.g., visual perception, mRNA transport) are less directly related, the dominant theme is cardiac development and signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0051028","count":3}]},{"hash":"1716347045808304519","title":"Dendritic cell development and innate immune signaling","description":"These proteins are enriched for terms related to dendritic cell differentiation and function (e.g., positive regulation of dendritic cell differentiation, dendritic cell cytokine production) and other myeloid lineage processes (myeloid progenitor differentiation, negative regulation of macrophage activation) as well as innate immune response and signaling (STAT phosphorylation). The combination of differentiation, cytokine production, and immune signaling points to a cluster centered on dendritic cell lineage development and innate immune activity, with some hematopoietic lineage connections (e.g., megakaryocyte development) that reflect broader myeloid context. Confidence reflects a coherent theme across the dominant terms. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0086091","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0042511","count":2}]},{"hash":"10244003959435397","title":"Unknown","description":"The top GO terms include GPCR signaling, follicular dendritic cell differentiation, cell migration, serine/threonine kinase regulation, calcium import, pinocytosis, membrane depolarization in cardiac cells and telomere maintenance processes. This mix spans multiple unrelated pathways and cellular contexts, with no single coherent function tying all 16 proteins together, so a specific functional label cannot be confidently assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0002268","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0071901","count":3},{"id":"GO:0098703","count":3}]},{"hash":"23659103947910110","title":"Cell Cycle and Signaling Regulators","description":"This cluster combines genes involved in mitosis (mitotic cell cycle, spindle assembly, cytokinesis), DNA repair, transcription, and key signaling pathways (Wnt, NF-kappaB) as well as ubiquitination. The common theme is regulatory proteins that coordinate cell division with signal transduction and gene expression, rather than a single pathway, suggesting a cohesive label around cell-cycle and signaling regulation. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002027","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0006302","count":2}]},{"hash":"1752667389546057811","title":"Nervous system signaling and stress responses","description":"Top GO terms point to neural function: memory and glutamatergic synaptic transmission suggest neuronal signaling, reinforced by ventral spinal cord development and synapse-related activity. The other terms indicate cellular stress and signaling contexts affecting the nervous system, including hypoxia response, inflammatory signaling (LPS), mechanical stimulus response, vitamin D responsiveness, vasoconstriction regulation, and apoptotic control. Taken together, the cluster appears to capture proteins involved in nervous system signaling with concurrent stress/immune responsiveness, giving a coherent, if broad, neural-centric signature.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007613","count":4},{"id":"GO:0051968","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0071456","count":3}]},{"hash":"355766433064179791","title":"Wnt signaling in muscle and neural development","description":"Top GO terms cluster around Wnt signaling and diverse developmental processes in muscle and nervous system, including cardiac muscle contraction regulation, skeletal muscle fiber development, chondrocyte development, and astrocyte activation/memory. This supports a unifying theme of developmental signaling guiding tissue specification in muscle and brain, though some terms (e.g., cellulose catabolic process) may be annotation noise. Overall, the cluster captures signaling-driven development of musculoskeletal and neural tissues.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007223","count":2},{"id":"GO:0086004","count":2},{"id":"GO:0048143","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0003151","count":2}]},{"hash":"1206758066035373933","title":"Cell Cycle and DNA Replication","description":"The terms predominantly describe cell division and DNA maintenance (DNA replication, cell cycle, chromatid cohesion, and meiosis-related cytokinesis). A few terms refer to development/morphogenesis, but the core signal is cell-cycle\u2013related, supporting labeling as 'Cell Cycle and DNA Replication'.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007111","count":1},{"id":"GO:0007409","count":1},{"id":"GO:0015914","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0006260","count":1}]},{"hash":"438187035550389671","title":"Innate immune defense and extracellular proteolysis","description":"This cluster centers on innate immune responses (defense against Gram-positive bacteria, complement activation, leukocyte migration, and chemokine regulation) and extracellular proteolytic processes (plasminogen activation, fibrinolysis). While a couple terms touch on unrelated processes like angiogenesis or clot liquefaction, the dominant themes are immune defense and proteolysis in the extracellular space, suggesting a cohesive functional group around innate immunity and proteolytic remodeling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0031639","count":3}]},{"hash":"1924939887655355727","title":"Broad Metabolism: Amino Acid, Sugar, and Isoprenoid Biosynthesis","description":"This cluster's GO terms span amino acid biosynthesis (methionine, threonine, homoserine), carbohydrate metabolism (galactose, galacturonate, fucose salvage, carbohydrate phosphorylation), and the mevalonate/isoprenoid pathway (farnesyl diphosphate biosynthesis, cholesterol biosynthesis), suggesting a broad metabolic role rather than a single pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009086","count":3},{"id":"GO:0006695","count":3},{"id":"GO:0000435","count":3},{"id":"GO:0061623","count":2},{"id":"GO:0009092","count":2}]},{"hash":"1878147954102828129","title":"Membrane Sugar and Ion Transporters","description":"This cluster centers on diverse transmembrane transport activities, including sugar (glucose/fructose/trehalose), vitamin, phosphate, xenobiotic, and sodium-dependent organic cation transport, along with stress-related responses to glucose starvation and osmotic stress. The common theme is transporter proteins mediating uptake/export of small molecules and ions across membranes.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":9},{"id":"GO:0035461","count":9},{"id":"GO:0042149","count":6},{"id":"GO:1990539","count":6},{"id":"GO:0006970","count":6}]},{"hash":"1919882339125005866","title":"Neural development and axonogenesis with apoptosis regulation","description":"The cluster prominently features axonogenesis and regulation of axon regeneration, alongside cell polarity establishment and apoptosis-related processes, indicating neural development and neuronal survival signaling. Metabolic and prostaglandin-responsive terms (glucose/PGE stimulus) suggest coordination of growth, signaling, and survival in developing neural tissue. ","confidence":"High","size":15,"edges":92,"triangles":319,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097194","count":15},{"id":"GO:0010954","count":15},{"id":"GO:0071333","count":15},{"id":"GO:0048679","count":15},{"id":"GO:0071380","count":15}]},{"hash":"558009294029643029","title":"Sulfur-containing amino acid metabolism","description":"The GO terms cluster around transsulfuration, hydrogen sulfide biosynthesis, serine biosynthesis/catabolism, and coenzyme M biosynthesis, pointing to sulfur-related amino acid metabolism as the core function. While some terms like DNA-templated transcription and cell division show up due to network connectivity, the dominant theme is sulfur-containing amino acid pathways. Confidence: Medium","confidence":"","size":15,"edges":89,"triangles":277,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0009097","count":4},{"id":"GO:0019346","count":4}]},{"hash":"2024592937789412959","title":"Immune signaling and vascular/hematopoietic development","description":"The top GO terms point to regulation of immune signaling pathways (STAT phosphorylation, Fc receptor signaling, NK T cell activation, IL-1 production) alongside endothelial/vascular development and hematopoietic lineages (endothelial morphogenesis, capillary formation, megakaryocyte development) and cell\u2013cell adhesion, suggesting a cluster of proteins coordinating immune regulation with vascular and blood cell development.","confidence":"Medium","size":15,"edges":70,"triangles":161,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042511","count":1},{"id":"GO:0001886","count":1},{"id":"GO:0035855","count":1},{"id":"GO:0016337","count":1},{"id":"GO:0071656","count":1}]},{"hash":"448437239497989706","title":"Plant flavonoid and lignin biosynthesis","description":"The top GO terms center on anthocyanin and cyanidin-3-O-glucoside biosynthesis, lignin metabolic processes, and related phenylpropanoid pathways (with supporting signals like genistein response and xenobiotic-related metabolism), pointing to a cluster of plant secondary metabolite biosynthesis, especially flavonoids and lignin. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":6},{"id":"GO:0017000","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0006711","count":4},{"id":"GO:0033485","count":4}]},{"hash":"143663709947615505","title":"Ribosome Biogenesis and Starvation Response","description":"This cluster centers on protein synthesis machinery (translation, ribosome biogenesis, large subunit assembly, translational termination) combined with starvation- and stringent-response signals, indicating a coordinated adjustment of translation and ribosome production under nutrient limitation. The presence of RNA pol II transcription and metabolic process terms suggests broader transcriptional and metabolic remodeling accompanying this translational program.","confidence":"High","size":15,"edges":83,"triangles":242,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":3},{"id":"GO:0042594","count":2},{"id":"GO:0015968","count":2},{"id":"GO:0000027","count":2}]},{"hash":"937874860900551311","title":"DNA Replication and Cell Cycle Regulation","description":"The top GO terms are dominated by DNA replication, mitotic cell cycle, DNA-templated transcription, and DNA repair, pointing to nuclear processes that maintain genome integrity and coordinate division. Additional terms like apoptosis execution, positive regulation of protein processing, and various stimulus responses suggest downstream signaling connections, but the core theme remains genome maintenance and cell-cycle control.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":14},{"id":"GO:0000278","count":13},{"id":"GO:0006351","count":12},{"id":"GO:0006281","count":12},{"id":"GO:0097194","count":11}]},{"hash":"128865821338992286","title":"GPCR-mediated vascular signaling and platelet activation","description":"This cluster centers on GPCR-related signaling tied to cardiovascular regulation and platelet function. The top terms include platelet activation; positive regulation of vasoconstriction and blood pressure via renin-angiotensin; dopamine receptor signaling that inhibits adenylate cyclase; regulation of acetylcholine metabolism; prostaglandin response; and general GPCR signaling pathway regulation, all suggesting a cohesive theme of GPCR-driven control of vascular tone, hemodynamics, and related signaling cascades. Some broader terms like immune response and posterior midgut development are present but appear ancillary to the core GPCR- and vascular-focused theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030168","count":8},{"id":"GO:0045907","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0001991","count":7},{"id":"GO:0007195","count":7}]},{"hash":"1437511272571058363","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around developmental processes and tissue formation across multiple organs (lens differentiation, heart-related EMT, left-right patterning, cartilage morphogenesis, placental development), with actin remodeling supporting morphogenesis. An outlier immune term exists but does not override the central theme of differentiation and organogenesis.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0051014","count":3},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2}]},{"hash":"1610775466000766920","title":"Embryogenesis and transcriptional regulation","description":"These proteins show a pattern of embryonic development terms (eye morphogenesis, in utero development) together with core transcriptional activity terms (RNA polymerase II\u2013mediated transcription and its negative regulation). The mix suggests a theme around developmental processes coordinated by transcriptional control, encompassing differentiation across multiple tissues. Hence, the label Embryogenesis and transcriptional regulation best captures the cluster\u2019s shared function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0048048","count":5},{"id":"GO:0001701","count":5},{"id":"GO:0001547","count":4},{"id":"GO:0060528","count":4}]},{"hash":"2170733142737007100","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0000388","count":1},{"id":"GO:0006396","count":1},{"id":"GO:0075522","count":1}]},{"hash":"703473203770169451","title":"Ciliary signaling and larval behavior regulation","description":"This cluster combines ciliary processes (intraciliary transport, cilium assembly, Smoothened signaling) with neural signaling and behavior-related terms (neuropeptide signaling, neuromuscular transmission, larval locomotion, mating-related turning, egg-laying, behavioral defense). The recurrent theme is that ciliary signaling pathways influence neural communication and behavioral outputs in larval/insect contexts, justifying a label that highlights both ciliary function and behavior regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042073","count":1},{"id":"GO:0007224","count":1},{"id":"GO:0060271","count":1},{"id":"GO:0010459","count":1},{"id":"GO:1901045","count":1}]},{"hash":"1394160822843911916","title":"Organogenesis Gene Regulation","description":"The top GO terms point to transcriptional control (RNA polymerase II transcription and related activity) alongside organ development across multiple tissues (somitogenesis; cardiac vascular smooth muscle development; pulmonary valve morphogenesis; renal structures). This combination suggests proteins that coordinate gene expression during organ formation, with some circadian regulation and metabolic context (glycolytic process) accompanying developmental programs. The label captures both the transcriptional and organogenesis themes without overfitting any single tissue. ","confidence":"Medium","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0043433","count":8},{"id":"GO:0032922","count":8},{"id":"GO:0045821","count":7},{"id":"GO:0001756","count":7}]},{"hash":"1000607173509616569","title":"Diverse signaling and transport regulation","description":"The Top Terms show multiple signaling-related processes (negative regulation of cAMP-dependent protein kinase activity; positive regulation of adenylate cyclase activity), along with transport/localization aspects (protein export from nucleus; protein localization to bud neck; potassium ion transmembrane transport) and regulatory controls (regulatory ncRNA-mediated gene silencing). There are a few outliers (defense response to Gram-positive bacterium; aerotaxis; response to antipsychotic drug; meiotic cell cycle regulation), suggesting the cluster is not driven by a single function but rather a collection of signaling and transport-related processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046827","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0031047","count":2},{"id":"GO:2000480","count":1},{"id":"GO:0097332","count":1}]},{"hash":"1344250748207664437","title":"Regulators of Signaling and Membrane Trafficking","description":"These proteins appear to modulate signaling pathways (ERK cascade, Rho signaling, opsin signaling) and membrane trafficking (Golgi to plasma membrane transport), with additional links to post-translational modification (ubiquitination, desumoylation) and immune signaling (IL-1\u03b2). While a couple of terms are less clearly connected (viral release, cell wall catabolic process), the dominant pattern is regulatory factors influencing signaling and trafficking, justifying a label focused on signaling regulation and membrane transport.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0006893","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0016998","count":1}]},{"hash":"1489994838094390814","title":"Ribosome biogenesis and rRNA maturation","description":"The top GO terms are centered on ribosome biogenesis and maturation of LSU rRNA (including 5.8S rRNA) and RNA methylation, indicating the cluster comprises proteins involved in large ribosomal subunit assembly and rRNA processing/modification. While a few other terms touch on broader cellular processes, the dominant signal is ribosome-related functions.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0036265","count":3}]},{"hash":"479869173553466933","title":"Neural development and brain morphogenesis","description":"This cluster shows neural development terms: forebrain development, neural tube closure, and dendrite morphogenesis, indicating a brain-related developmental function. While there are broader terms like DNA-templated transcription and DNA repair, the neural-focused terms dominate, supporting a neural development label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0030900","count":2}]},{"hash":"782157326301657509","title":"Unknown","description":"The GO terms span neural plasticity, reproduction, RNA processing, ion transport, and development, with no single shared function linking them and no edges among proteins, so there isn\u2019t a cohesive theme to name the cluster.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":2},{"id":"GO:0048172","count":2},{"id":"GO:0007283","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0006851","count":1}]},{"hash":"889426270634750973","title":"Viral entry and genome integration","description":"The top GO terms cluster around viral-host interactions and genome modification, including entry into the host nucleus, proviral latency, RNA-templated DNA synthesis, DNA integration, and retrotransposition. Related terms for DNA replication and host processing (e.g., proteolysis, siRNA regulation) may reflect downstream processing of viral elements. Together these terms point to a theme of viral genome entry, replication, and integration, with retroelement activity as a supporting aspect.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":2},{"id":"GO:1903704","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0006508","count":1}]},{"hash":"1514114742733526610","title":"Starch and sucrose catabolism","description":"The cluster shows GO terms for starch catabolic process and sucrose catabolic process, indicating a theme of carbohydrate breakdown among the proteins. The obsolete GO term adds little interpretive value, and there are no network edges to further support functional coupling, so the label is based on the annotated carbohydrate metabolism functions.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005983","count":1},{"id":"GO:0005987","count":1},{"id":"GO:0090305","count":1}]},{"hash":"8909517975875996","title":"Platelet activation and coagulation","description":"The dominant GO terms\u2014platelet activation, fibrinolysis, plasminogen activation, and blood coagulation (common pathway)\u2014strongly indicate a hemostasis/coagulation cluster. Endothelial cell apoptotic regulation and triglyceride homeostasis appear less central, and a behavior term is likely noise; overall, the theme is coagulation with fibrinolysis.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030168","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0031639","count":3},{"id":"GO:1902042","count":3},{"id":"GO:0035641","count":2}]},{"hash":"311273345048409757","title":"Mitochondrial import and chaperone folding","description":"The top GO terms cluster around mitochondrial protein targeting/insertion and chaperone-mediated transport and folding, with supporting signals for proteostasis (quality control) and related cytoskeletal processes. This points to a cohesive group of proteins involved in mitochondrial protein import and chaperone-assisted folding, with a few peripheral terms that may reflect additional roles.","confidence":"Medium","size":15,"edges":38,"triangles":42,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":3},{"id":"GO:0006626","count":3},{"id":"GO:0072321","count":3},{"id":"GO:0007021","count":2},{"id":"GO:0045657","count":2}]},{"hash":"1935546485777497538","title":"Ubiquitin-Proteasome System and ERAD","description":"This cluster is dominated by ubiquitin-mediated protein turnover terms: SCF-dependent ubiquitination, ubiquitin-dependent proteasomal degradation, ERAD, and specific ubiquitin linkages (K48, K11), plus autoubiquitination. A peroxisome import term and a late NF-kappaB regulation term also point to broader ubiquitin signaling roles. Overall, the proteins likely function in ubiquitin\u2011driven proteolysis and quality control, especially ER-associated degradation. ","confidence":"High","size":15,"edges":73,"triangles":166,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":8},{"id":"GO:0031571","count":6},{"id":"GO:0030433","count":6},{"id":"GO:1902916","count":6},{"id":"GO:0042787","count":6}]},{"hash":"1149814265266916598","title":"Neuronal signaling, ion transport, and plasticity","description":"The cluster centers on neural communication and learning, with terms for glutamatergic and GABAergic synaptic transmission, excitatory postsynaptic potentials, and positive regulation of long-term potentiation, plus behavior-related terms (startle, locomotion, sound perception, conditioned taste aversion) and Na+/K+ ion transport. This combination points to a cohesive neural circuit module governing neurotransmission, plasticity, and sensory-driven behaviors.","confidence":"High","size":15,"edges":13,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0001661","count":4},{"id":"GO:0035725","count":4}]},{"hash":"557130236024763108","title":"Unknown","description":"The GO terms are highly diverse (sporulation, necroptosis/apoptosis regulation, placental development, Wnt signaling, pancreatic cell proliferation, and chromosome segregation), with no single cohesive function tying the cluster together. Therefore, Unknown with no confidence.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030435","count":2},{"id":"GO:1902443","count":2},{"id":"GO:0060712","count":2},{"id":"GO:1902527","count":2},{"id":"GO:0007059","count":2}]},{"hash":"1607754057760508153","title":"ER-Golgi Vesicle Transport & Endocytosis","description":"This cluster is enriched for vesicle trafficking between the ER and Golgi (retrograde and ER-to-Golgi transport), as well as general protein transport and endocytosis, indicating a core role in the secretory pathway. Other terms like signaling and differentiation may reflect regulatory context but do not override the central trafficking theme.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035900","count":3},{"id":"GO:0030521","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0006897","count":2}]},{"hash":"1864241366478170655","title":"Glycan biosynthesis and glycoprotein cell-surface processes","description":"Most top GO terms point to glycan biosynthesis and glycoprotein metabolism (arabinogalactan protein metabolism, O-linked glycosylation via hydroxyproline, poly-N-acetyllactosamine biosynthesis) and cell-surface roles such as adhesion and polarity. The presence of plant- and animal/insect-associated terms suggests a cluster of proteins involved in glycan assembly and glycoprotein-mediated cell surface functions rather than a single organism-specific pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080147","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0048354","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0042248","count":3}]},{"hash":"1302024724027946647","title":"Immune signaling and metabolic regulation","description":"The top GO terms cluster around immune cell activity (T cell activation, neutrophil chemotaxis, xenophagy) with accompanying metabolic regulation (lipid catabolism, fat cell differentiation, glucose response). This suggests a broader program of signaling at the intersection of immune responses and metabolism rather than a single enzymatic function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007165","count":2},{"id":"GO:0045445","count":2},{"id":"GO:0002317","count":2},{"id":"GO:0098792","count":2},{"id":"GO:0050994","count":2}]},{"hash":"1743938899950872831","title":"Xenobiotic and Metabolite Membrane Transport","description":"The top GO terms show strong enrichment for transmembrane transport of xenobiotics, vitamins, amino acids, heme, and cholesterol, plus xenobiotic export, indicating a shared function as membrane transporters for diverse small molecules. The presence of a mitochondrial-related term (cytochrome complex assembly) doesn't contradict this, as many transport processes occur in mitochondria or involve mitochondrial carrier systems. Overall, these proteins appear to form a transport-associated cluster for small molecule movement across membranes.","confidence":"High","size":15,"edges":25,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":12},{"id":"GO:0042891","count":12},{"id":"GO:0035461","count":12},{"id":"GO:0017004","count":6},{"id":"GO:0046618","count":6}]},{"hash":"696549372036119962","title":"Bacterial Cell Division and Peptidoglycan Synthesis","description":"This cluster is dominated by GO terms centered on cell division, cell wall organization, and peptidoglycan biosynthesis, with supporting terms on cell shape regulation, suggesting proteins involved in bacterial cell envelope biogenesis and cytokinesis. A few terms reflect plant/animal processes (chlorophyll, GPCR signaling, morphine), but they are less represented and likely noise. Confidence: High.","confidence":"","size":15,"edges":3,"triangles":0,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0071555","count":3},{"id":"GO:0009252","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0055059","count":3}]},{"hash":"1467819854228093327","title":"Ubiquitin-Dependent NF-\u03baB Signaling in Innate Immunity","description":"The top terms cluster around ubiquitination processes (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination) and NF-\u03baB pathway activation (I\u03baB phosphorylation, TNF-mediated signaling) alongside innate immune response. This points to proteins coordinating ubiquitin-mediated regulation with NF-\u03baB\u2013driven inflammatory signaling in innate immunity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0032088","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0071260","count":4},{"id":"GO:0016567","count":4}]},{"hash":"1047337720709493444","title":"Unknown","description":"The top GO terms span immune signaling (NOD2 pathway, NF-kappaB regulation, follicular dendritic cell differentiation), cell movement, calcium transport, endocytosis, and even cardiac action potential processes, with no single cohesive theme tying all proteins together. The lack of a clear shared function or interaction pattern suggests this cluster does not represent a single, interpretable biological module.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":9},{"id":"GO:0071260","count":8},{"id":"GO:0070431","count":8},{"id":"GO:0002268","count":7},{"id":"GO:0016477","count":7}]},{"hash":"639215896818141023","title":"Erythrocyte maturation and blood oxygen transport","description":"The cluster is driven by red blood cell\u2013related processes: erythrocyte maturation, enucleate differentiation, and oxygen transport, with hypoxia response supporting RBC function. Coagulation terms add a blood homeostasis aspect. A few terms related to immune signaling or endocytosis are present but appear incidental, so the dominant theme centers on erythrocyte biology and hemostasis.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":2},{"id":"GO:0045061","count":2},{"id":"GO:0043249","count":1},{"id":"GO:0043353","count":1},{"id":"GO:0015671","count":1}]},{"hash":"462141997952525417","title":"Mitosis and ubiquitin regulation","description":"The dominant GO terms point to cell division processes (mitotic cell cycle, microtubule-based movement) and protein ubiquitination, which commonly regulate progression through mitosis and apoptosis. Several terms also touch on cell survival and cytoskeletal dynamics, suggesting a theme of cell-cycle control and ubiquitin-mediated regulation; immune-related terms appear less central to the cluster\u2019s core function. Confidence reflects this moderate cohesiveness.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0071260","count":2},{"id":"GO:0045627","count":2},{"id":"GO:0043066","count":2}]},{"hash":"135142932260204488","title":"GPCR-Regulated Neuroimmune Signaling","description":"This cluster centers on GPCR-mediated signaling and its systemic regulation, including dopamine and acetylcholine pathways and prostaglandin responses, as well as blood pressure regulation via the renin-angiotensin axis and vascular differentiation. Immune-related terms (cytolysis, IL-1 beta production, immune response) co-occur, suggesting a broader signaling context across neuroendocrine and immune systems. A midgut development term may be an outlier. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":6},{"id":"GO:0007195","count":6},{"id":"GO:0060408","count":6},{"id":"GO:0007497","count":6},{"id":"GO:0006955","count":6}]},{"hash":"234120051563434748","title":"Auditory-vestibular neural signaling and dopamine secretion","description":"Most terms describe neuronal signaling in auditory/vestibular pathways (sound perception, vestibulocochlear nerve development, glycinergic synapses, acetylcholine receptor signaling, membrane depolarization) and dopaminergic modulation (dopamine secretion, drug response, cocaine). An outlier term about ovulation rhythm doesn\u2019t change the overall theme. Therefore the cluster represents auditory-vestibular neural signaling with dopamine regulation.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":15},{"id":"GO:0060112","count":15},{"id":"GO:0060012","count":15},{"id":"GO:0021562","count":15},{"id":"GO:2001023","count":15}]},{"hash":"4162129623399784","title":"Inflammatory Leukocyte Adhesion and Migration","description":"This cluster centers on leukocyte trafficking and activation during inflammation, as shown by terms for neutrophil extravasation, monocyte activation, macrophage fusion, and integrin-mediated cell adhesion. Additional related terms (keratinocyte migration, proteolysis, TNFSF11/RANKL production, and pain perception) support a tissue-remodeling and inflammatory milieu where immune cells migrate to sites of injury or inflammation and interact with neighboring cells.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0019233","count":3},{"id":"GO:2000309","count":2},{"id":"GO:2000391","count":2},{"id":"GO:0033630","count":2}]},{"hash":"2178580722793370440","title":"Ubiquitin-Proteasome Proteolysis in Meiosis","description":"The top terms are ubiquitin-dependent protein catabolic processes and SCF-dependent proteasomal degradation, pointing to ubiquitin-proteasome\u2013mediated proteolysis. Related terms like spindle assembly in female meiosis I and oocyte maturation suggest this proteolysis regulates meiotic progression and early development, with metal-response terms serving as secondary context. Overall, the cluster appears to center on controlled protein turnover during meiosis and maturation.","confidence":"High","size":14,"edges":18,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0031146","count":13},{"id":"GO:0046685","count":12},{"id":"GO:0051436","count":12},{"id":"GO:0006516","count":12}]},{"hash":"2199615833080513964","title":"Sugar and ion transport under osmotic stress","description":"The cluster centers on plasma membrane transport, especially sugar uptake (fructose, glucose, trehalose) and various ion/organic transport processes, with an emphasis on osmotic stress and nutrient-starvation responses. Together these terms suggest a group of transporters adapting membrane transport to changing osmotic and nutrient conditions.","confidence":"High","size":14,"edges":75,"triangles":201,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":13},{"id":"GO:1990539","count":13},{"id":"GO:0006970","count":13},{"id":"GO:0052106","count":13},{"id":"GO:0006817","count":13}]},{"hash":"445352751133110782","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":17,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015012","count":6},{"id":"GO:0006711","count":6},{"id":"GO:0030205","count":6},{"id":"GO:0030210","count":6},{"id":"GO:0050427","count":6}]},{"hash":"1087606308547183691","title":"Metabolic signaling and energy homeostasis","description":"This cluster combines terms tied to metabolism and energy production (electron transport chain, thermogenesis) with signaling pathways (GPCR signaling, GTPase regulation) and physiological regulation (blood pressure, proliferation), plus tissue- and sensation-related terms (retina development, pain perception, temperature response). The shared theme appears to be signaling networks that regulate cellular energy state and systemic physiology across tissues, rather than a single specific function. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008283","count":7},{"id":"GO:0008284","count":7},{"id":"GO:0060041","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0045777","count":6}]},{"hash":"2241005996395287064","title":"GPCR signaling in blood pressure regulation","description":"The top GO terms point to GPCR pathways that activate or inhibit adenylyl cyclase and regulate arterial pressure (positive regulation of blood pressure, renin-angiotensin system, dopamine and acetylcholine signaling). While a few terms like electron transport, immune response, and midgut development appear, the dominant pattern is GPCR-mediated signaling linked to cardiovascular control, suggesting this as the core theme of the cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0007190","count":11},{"id":"GO:0001991","count":10}]},{"hash":"726520356630951173","title":"Acetylation-driven chromatin regulation and polyamine metabolism","description":"Top terms cluster around multiple acetylation processes (N-terminal, peptidyl-lysine, spermidine, spermine) and chromatin-related regulation (subtelomeric heterochromatin formation), with additional signals for development (leaf formation, angiogenesis) and polyamine metabolism (putrescine, ectoine biosynthesis). This suggests a cohesive theme where acetylation modulates chromatin state and gene expression, intertwined with polyamine metabolism. Confidence: Medium","confidence":"","size":14,"edges":54,"triangles":98,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":8},{"id":"GO:0006348","count":8},{"id":"GO:0017198","count":8},{"id":"GO:0018003","count":8},{"id":"GO:0017196","count":7}]},{"hash":"1171260557725885139","title":"Mitochondrial dynamics and innate immune signaling","description":"This cluster is dominated by mitochondrial-related terms (morphogenesis, stress-induced fusion, inner mitochondrial membrane organization, inheritance) suggesting a focus on mitochondrial maintenance. It also includes immune signaling terms (regulation of TLR3 signaling and IL-2 production), indicating a link between mitochondria and innate immune pathways. Some terms touch on membrane organization and matrix interactions, which may be peripheral but still align with the broader theme of organelle-membrane dynamics influencing immune signaling.","confidence":"Medium","size":14,"edges":43,"triangles":58,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045541","count":5},{"id":"GO:0070584","count":5},{"id":"GO:1990046","count":5},{"id":"GO:0034141","count":5},{"id":"GO:0022617","count":5}]},{"hash":"1633595059257196871","title":"GPCR-cAMP signaling in blood pressure regulation","description":"This cluster is dominated by GO terms related to GPCR signaling that modulates adenylate cyclase activity (activation and inhibition), and several terms point to blood pressure regulation (positive regulation of blood pressure; renin-angiotensin\u2013mediated arterial blood pressure). Additional terms involve acetylcholine and dopamine receptor signaling and prostaglandin responses, all of which can be linked to GPCR-cAMP pathways. A couple terms (electron transport chain, posterior midgut development) are less directly connected and may reflect broader or pleiotropic roles, but the central theme remains GPCR-driven signaling impacting cardiovascular regulation and related processes.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0007190","count":13},{"id":"GO:0001991","count":12}]},{"hash":"820782221789792092","title":"GPCR-driven vascular-immune signaling","description":"This cluster is dominated by GO terms centered on GPCR signaling, including positive regulation of GPCR signaling, dopamine receptor signaling, and prostaglandin/acetylcholine-related signaling, which are all downstream of GPCR activity. The presence of vascular-related terms (renin-angiotensin and cardiac vascular smooth muscle differentiation) alongside immune/inflammatory terms (immune response, IL-1beta production, cytolysis) suggests a unifying theme of GPCR-regulated signaling that links vascular function with immune responses. A developmental term (posterior midgut development) appears ancillary, not defining the core theme. ","confidence":"High","size":14,"edges":5,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":7},{"id":"GO:0007195","count":7},{"id":"GO:0060408","count":7},{"id":"GO:0007497","count":7},{"id":"GO:0006955","count":7}]},{"hash":"1474852261195388966","title":"GPCR Signaling in Immunity and Cardiovascular Regulation","description":"The proteins show strong representation of GPCR-related processes (positive GPCR signaling, dopamine receptor signaling, prostaglandin response, acetylcholine metabolism) alongside immune activity (immune response, IL-1\u03b2 production, cytolysis) and a cardiovascular cue (renin-angiotensin\u2013mediated blood pressure). This suggests a coherent theme around GPCR-driven signaling that links inflammatory responses with cardiovascular regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030168","count":10},{"id":"GO:0001991","count":9},{"id":"GO:0007195","count":9},{"id":"GO:0060408","count":9},{"id":"GO:0007497","count":9}]},{"hash":"1764275636458118988","title":"Unknown","description":"The GO terms are spread across heart and uterus development, visual perception, calcium signaling regulation, GTPase activity, cell migration, and dendritic spine development. This mix suggests no single cohesive function for the cluster, so a precise label cannot be assigned.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0071407","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0051281","count":2}]},{"hash":"512103916861390359","title":"Nucleobase Transporters","description":"The top GO terms are dominated by transport of nucleobases and related metabolites (adenine, hypoxanthine, guanine, uracil, xanthine, urate) across the plasma membrane, indicating a cluster of nucleobase/nucleoside transporters; a solitary glycosylation term appears incidental.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:1903825","count":2},{"id":"GO:0042906","count":2},{"id":"GO:0098702","count":2},{"id":"GO:0035344","count":2}]},{"hash":"1483040140779432462","title":"Mitotic spindle and centrosome cycle","description":"The strongest terms are spindle assembly and centrosome cycle, which pointe to mitosis and cell division as the core theme of this cluster. While there are additional terms related to growth, migration, and signaling, they appear as supportive or peripheral contexts. Thus the label Mitotic spindle and centrosome cycle best represents the dominant function of the protein cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":4},{"id":"GO:0051225","count":4},{"id":"GO:0007098","count":4},{"id":"GO:0002268","count":3},{"id":"GO:0016477","count":3}]},{"hash":"647313234625243343","title":"Pain perception and neuronal signaling","description":"The cluster\u2019s top GO terms repeatedly point to sensory detection of pain (mechanical and chemical stimuli) and neuron development, with supporting signaling pathway terms (integrin signaling, ERK cascade, MAPKK activity). While metabolic terms appear, the strongest signals align with neuronal signaling and pain perception, suggesting a theme around how neurons sense and respond to painful stimuli and develop. Confidence in this thematic label is Moderate, given some unrelated terms present.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000186","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0050966","count":2},{"id":"GO:0050968","count":2}]},{"hash":"34333903458924602","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":7,"triangles":0,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000472","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0043966","count":2}]},{"hash":"1688845208223244198","title":"Neural Development and Signaling","description":"The Top Terms cluster around neural development and signaling: neuronal migration from the subventricular zone to the olfactory bulb, Wnt signalosome assembly, dopamine receptor signaling, regulation of excitatory postsynaptic potential, mechanotransduction, neuromuscular balance, and neuronal metabolic signaling (CAMKK\u2013AMPK). Together these point to neural development, synaptic regulation, and motor/balance functions. An outlier term about kidney size likely reflects pleiotropy rather than a core cluster theme, so it does not outweigh the neural-focused interpretation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035564","count":7},{"id":"GO:0071260","count":7},{"id":"GO:0022028","count":7},{"id":"GO:1905279","count":7},{"id":"GO:1905289","count":7}]},{"hash":"97152292284601358","title":"Neuronal development and synapse assembly","description":"The top GO terms cluster around nervous system development, neuron cell\u2013cell adhesion, and synapse assembly (with additional terms on inner ear development), suggesting a common role in neural development and synaptic organization. Some terms (e.g., hematopoietic differentiation, transcription regulation) may reflect broader or pleiotropic functions, but the neural theme is predominant.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007158","count":4},{"id":"GO:0071347","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0030851","count":4},{"id":"GO:0045648","count":4}]},{"hash":"2253971679967094324","title":"Mitochondrial metabolite transport and nutrient signaling","description":"The cluster centers on transport and handling of metabolic intermediates (NAD transmembrane transport, malate-aspartate shuttle, alpha-ketoglutarate transport, manganese ion transport) and responsiveness to nutrient cues (insulin/IGF stimuli, amino acid starvation, insulin signaling), which together point to mitochondrial metabolite transport and nutrient-sensing processes that can influence metabolic regulation and, in a tissue context like liver, regeneration. The liver regeneration term adds tissue-context relevance but does not override the primary metabolic theme.","confidence":"Medium","size":14,"edges":12,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0097421","count":7},{"id":"GO:0015886","count":6},{"id":"GO:0034198","count":6},{"id":"GO:1990314","count":6},{"id":"GO:0035352","count":6}]},{"hash":"1039110597681507474","title":"Retrotransposons and Proviral Integration","description":"The dominant GO terms cluster around DNA transposition, retrotransposition, DNA integration, and proviral latency, which point to mobile genetic elements and viral integration into host genomes. Additional hints of symbiont/virus entry and virus\u2013host interactions support this theme, with a peripheral note about splicing machinery that can be involved in genome processing during such events. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":2},{"id":"GO:0015074","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0032197","count":1},{"id":"GO:0046718","count":1}]},{"hash":"494124124298929030","title":"Virion Assembly and Virus-Host Interaction","description":"Dominant terms center on steps of the viral life cycle\u2014virion assembly, fusion of the viral membrane with the host, and release from the host cell\u2014pointing to virus-related processes. Additional terms about leukocyte migration and protein secretion regulation suggest host response and trafficking involvement, though a few outliers (like sepal formation) are less related. Overall, the cluster seems anchored in viral entry/assembly/egress and host interactions.","confidence":"Medium","size":14,"edges":5,"triangles":1,"max_degree":2,"top_function":"protein folding","top_go_terms":[{"id":"GO:1901407","count":5},{"id":"GO:0019076","count":4},{"id":"GO:0050900","count":4},{"id":"GO:0019064","count":4},{"id":"GO:2000276","count":4}]},{"hash":"2193981116422943698","title":"Cell Cycle and Ribosome Biogenesis","description":"The cluster is dominated by GO terms tied to cell division, mitotic processes (mitotic spindle assembly, mitotic cell cycle), DNA-templated transcription, and ribosome biogenesis, with supporting points from protein ubiquitination. This combination points to a cohesive theme of cell-cycle progression coupled with protein synthesis and turnover. A few terms like neuron projection development and invasive growth may reflect broader regulatory connections or annotation noise, but they do not outweigh the central cell-cycle/ribosome biogenesis signal.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0051301","count":4}]},{"hash":"1684730036709849856","title":"Calcium signaling and membrane trafficking regulation","description":"The GO terms cluster around signaling modulation and membrane-associated processes: calcium ion import, membrane depolarization in cardiac cells, pinocytosis regulation, and modulation of serine/threonine kinase activity. There are also notes of vitamin D response and cell growth regulation, suggesting broader signaling and growth control, while dendritic cell differentiation and telomere localization appear more peripheral. Overall, the proteins seem tied to signaling control with emphasis on calcium dynamics and membrane-related processes.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0001558","count":4},{"id":"GO:0002268","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0071901","count":3}]},{"hash":"486848238249262730","title":"Lipid catabolism and membrane lipid remodeling","description":"The top terms are dominated by triglyceride catabolic/mobilization processes and phospholipid catabolic remodeling (phosphatidylcholine and phosphatidylethanolamine), indicating a core theme of lipid metabolism and membrane lipid turnover. A few outliers relate to immune or synaptic processes, likely from multifunctional proteins, but the lipid-related terms are the strongest signal. Confidence: Medium","confidence":"","size":14,"edges":31,"triangles":20,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0051963","count":2},{"id":"GO:0036153","count":2},{"id":"GO:2000480","count":2}]},{"hash":"1640083205196325381","title":"Neurotransmission and sensory perception","description":"The top GO terms cluster around neural signaling and sensory processing: ion transport (potassium, sodium) across membranes, excitatory postsynaptic potentials, and GABA signaling, along with locomotory behavior and sensory modalities (visual perception, touch) and conditioned taste aversion. These collectively point to neuronal communication and sensory circuitry. A few terms (viral release, cell wall macromolecule catabolic process) appear as noise and are not core to the cluster\u2019s theme, but do not overshadow the dominant neuronal function signal.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":9},{"id":"GO:0007626","count":9},{"id":"GO:0060079","count":9},{"id":"GO:0001661","count":9},{"id":"GO:0035725","count":9}]},{"hash":"1503586649405438978","title":"Ribosome Biogenesis and RNA Processing","description":"The frequent terms include ribosome biogenesis and small subunit biogenesis, plus tRNA modification, which together point to roles in ribosome assembly and RNA maturation. While glucose catabolism and cell cycle features are present, the dominant signal is ribosome-related RNA processing.","confidence":"Medium","size":14,"edges":9,"triangles":0,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042135","count":3},{"id":"GO:0006400","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0000747","count":3},{"id":"GO:1901001","count":3}]},{"hash":"376651714825393167","title":"Mitosis and cell cycle control","description":"The cluster is dominated by GO terms related to cell division, the cell cycle, and mitosis (cell division, cell cycle, mitotic cell cycle, exit from mitosis, mitotic regulation), with supporting terms for transcription regulation and organelle inheritance, suggesting a cohesive role in mitotic progression and cell-cycle control, with related trafficking processes that support mitosis.","confidence":"High","size":14,"edges":8,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0051291","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0071985","count":2}]},{"hash":"886439933256237859","title":"Unknown","description":"The top GO terms are highly diverse, spanning ubiquitination, various ion and intercellular transports, protein assembly, developmental processes (foregut morphogenesis, left/right nervous system asymmetry), germ line maintenance in both sexes, and inflammatory signaling. There is no clear, cohesive biological theme tying these proteins together, so a simple unknown label with no confidence is most appropriate.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0034214","count":1},{"id":"GO:0010496","count":1},{"id":"GO:0030727","count":1}]},{"hash":"1397986597797903209","title":"NF-kB driven immune signaling","description":"Most frequent terms center on T cell receptor signaling, I-kappaB phosphorylation (NF-\u03baB activation), and defense/inflammatory responses, pointing to a cluster of proteins involved in immune signaling. Developmental GO terms appear but are less central; the core theme is NF-\u03baB\u2013related immune/inflammatory signaling.","confidence":"Medium","size":14,"edges":18,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0070208","count":3}]},{"hash":"1103561460450309633","title":"Developmental differentiation and transcription regulation","description":"These terms cluster around differentiation in multiple tissues (intestinal epithelium, skeletal muscle) and regulation of gene expression (RNA polymerase II transcription) plus related processes like glucocorticoid response and ubiquitin-dependent proteolysis. The common thread is broad developmental differentiation coupled with transcriptional control, rather than a single, cohesive pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060575","count":1},{"id":"GO:0048642","count":1},{"id":"GO:0018027","count":1},{"id":"GO:0006469","count":1},{"id":"GO:0035914","count":1}]},{"hash":"509789866110769808","title":"Small Molecule Metabolism","description":"The terms cluster around metabolic transformations of small organic compounds (retinol/retinal, ethanol, fatty acids, GABA, putrescine, proline, stilbenes) with both biosynthetic and catabolic processes. This pattern suggests proteins involved in broad metabolite processing rather than a single, tightly defined pathway, hence a general metabolism label.","confidence":"Medium","size":14,"edges":88,"triangles":331,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":5},{"id":"GO:0006069","count":4},{"id":"GO:0006068","count":4},{"id":"GO:0006633","count":4},{"id":"GO:0009450","count":3}]},{"hash":"775193476444405522","title":"Unknown","description":"The terms span vesicle trafficking (ER to Golgi), calcium/NFAT signaling, adenosine biosynthesis, spindle-kinetochore attachment, cardiovascular remodeling, DNA damage checkpoints, vascular branching, and responses to cocaine, DNA replication, and meiotic recombination signaling. This broad mix lacks a single cohesive theme or shared biological process that ties all proteins together, so a specific functional label is not justifiable from the given GO terms. Therefore, Unknown.","confidence":"","size":14,"edges":13,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0051531","count":1},{"id":"GO:0046086","count":1},{"id":"GO:0051315","count":1},{"id":"GO:1903244","count":1}]},{"hash":"1051329366572528130","title":"Unknown","description":"The top GO terms span diverse biological themes: fat cell differentiation, cilium assembly, dendritic cell differentiation, cell migration, signaling regulation, calcium transport, endocytosis, cardiac membrane depolarization, and telomeric protein localization. There is no single coherent functional theme tying these processes together, suggesting a heterogeneous cluster rather than a unified biological module. Confidence: None","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":3},{"id":"GO:0060271","count":3},{"id":"GO:0002268","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0071901","count":2}]},{"hash":"538007317164915874","title":"Neurotransmitter signaling and behavior","description":"This cluster centers on neural signaling pathways and behavior-related processes, with GO terms like octopamine biosynthesis and signaling, dopamine catabolic process, and G protein-coupled acetylcholine receptor signaling, plus behavioral associations such as maternal behavior and behavioral response to ethanol, and even visual perception. A few terms (fibrinolysis, leukocyte migration) appear as outliers noise but do not define the main theme. Hence, a label focusing on nervous signaling and behavior fits best.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":2},{"id":"GO:0050900","count":1},{"id":"GO:0007601","count":1},{"id":"GO:0048149","count":1},{"id":"GO:0006589","count":1}]},{"hash":"1031448159306856756","title":"Mitotic progression and transcriptional regulation","description":"Based on the GO terms, the cluster is dominated by mitotic processes (G2/M transition, re-entry into the cell cycle, spindle pole separation, chromosome condensation) and DNA-templated transcription, indicating coordinated transcriptional control during cell division. Additional signals related to growth and proliferation (angiogenesis, mammary gland epithelial cell proliferation, insulin signaling) support a proliferative phenotype, but the core theme remains mitosis with transcriptional regulation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0000086","count":5},{"id":"GO:0060291","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0046826","count":4}]},{"hash":"1057174663177304568","title":"Microtubule nucleation and spindle assembly","description":"The GO terms cluster around gamma-tubulin complex localization, microtubule nucleation at MTOCs/spindle poles, and mitotic spindle assembly, pointing to centrosome/MTOC-driven microtubule organization and chromosome segregation as the shared theme. Other terms are present but less central to this core function.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045907","count":2},{"id":"GO:0051415","count":1},{"id":"GO:0051417","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0033566","count":1}]},{"hash":"122123327723153797","title":"Apoptosis and necroptosis regulation with TLR signaling","description":"This cluster is enriched for regulation of apoptotic and necroptotic pathways (apoptosis, necroptosis, ripoptosome), along with regulation of Toll-like receptor signaling and protein ubiquitination. The co-occurrence suggests a module controlling cell death in the context of innate immune signaling, with ubiquitin-mediated regulation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":3},{"id":"GO:0034121","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0060544","count":3}]},{"hash":"1574831077562887491","title":"Intracellular cholesterol and sterol transport","description":"This cluster centers on cholesterol/sterol transport and metabolism, with terms like cholesterol transport, sterol import, bile acid metabolism, and regulation of cholesterol metabolism. Additional related terms (intracellular sterol transport, ER to Golgi ceramide transport, ER organization, and plasma membrane sterol distribution) point to coordinated lipid trafficking and lipid homeostasis within cellular compartments, suggesting a cohesive theme of intracellular lipid handling and trafficking rather than a single isolated process.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008206","count":1},{"id":"GO:0032383","count":1},{"id":"GO:0035376","count":1},{"id":"GO:0030301","count":1},{"id":"GO:0090181","count":1}]},{"hash":"362864455569263108","title":"Dopaminergic Neuronal Signaling and Sensory Perception","description":"The top GO terms point to neural signaling and sensory processing\u2014dopaminergic synaptic transmission, visual perception and learning, pain perception, and drug-related behavioral responses\u2014tueled by ERK/MAPK signaling. A few terms like heart development and tight junction regulation are less central, but the prevailing theme supports nervous-system signaling and sensory/drug response roles.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071380","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0048148","count":10},{"id":"GO:0007601","count":10},{"id":"GO:0007507","count":10}]},{"hash":"834021776963489431","title":"GPCR signaling and immune modulation","description":"The cluster\u2019s top GO terms cluster around GPCR-related signaling (positive regulation of GPCR signaling, dopamine receptor signaling, prostaglandin response, acetylcholine metabolism regulation) along with immune/inflammatory terms (immune response, regulation of IL-1\u03b2 production, cytolysis). This points to proteins involved in GPCR-mediated signaling with cross-talk to immune outputs, even though a midgut development term is present, the dominant theme is signaling and immune modulation. ","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":12},{"id":"GO:0001991","count":11},{"id":"GO:0007195","count":11},{"id":"GO:0060408","count":11},{"id":"GO:0007497","count":11}]},{"hash":"97923724458318984","title":"Metabolic energy pathways and lipid synthesis","description":"The cluster shows enrichment in fatty acid biosynthesis, galactose catabolic processes, and pyruvate fermentation to ethanol, all pointing to core energy metabolism and lipid-related pathways. Additional terms like prostaglandin metabolism and response to copper ion indicate broader metabolic and stress-related roles, while the presence of extracellular signal regulation hints at signaling-context linkage. Overall, the proteins appear to participate in diverse metabolic processes tied to energy production and lipid metabolism rather than a single specific function.","confidence":"Medium","size":13,"edges":53,"triangles":93,"max_degree":10,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0006633","count":7},{"id":"GO:0006116","count":7},{"id":"GO:0006693","count":7},{"id":"GO:0046688","count":7}]},{"hash":"651825989047661554","title":"Inflammation and coagulation","description":"The cluster is enriched for immune-related terms (defense response to Gram-positive bacterium, leukocyte migration, regulation of chemokine production) and vascular components (blood coagulation, regulation of arterial pressure), suggesting a dominant theme of inflammatory signaling linked to coagulation. Other terms like DNA-templated transcription and multicellular growth are broad, but the strongest signal points to immune/inflammatory and coagulation processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0042127","count":3}]},{"hash":"532502012002419166","title":"Cardio-neural signaling and ECM regulation","description":"This cluster\u2019s terms span regulation of cardiac conduction and blood coagulation (cardiovascular), neuron projection development (neural), EGFR signaling (growth signaling), thyroid hormone transport (endocrine), and extracellular matrix assembly (tissue remodeling). The common thread is regulatory modulation of signaling pathways affecting heart, brain, and the ECM, suggesting proteins that coordinate signaling and remodeling across these tissues.","confidence":"Medium","size":13,"edges":55,"triangles":117,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0032930","count":2},{"id":"GO:0010951","count":2},{"id":"GO:2000266","count":1},{"id":"GO:1903779","count":1},{"id":"GO:0014067","count":1}]},{"hash":"212183839972813520","title":"Sugar and ion transporters under osmotic stress","description":"Based on the GO terms, there are multiple sugar transport (galactose, fructose, arabinose, sialic acid) and ion transport (potassium, sodium, phosphate) activities, along with cellular responses to glucose starvation and osmotic stress. This pattern points to a cluster of membrane transport proteins focused on carbohydrate uptake and ion balance, with osmotic stress responsiveness as a unifying theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":1},{"id":"GO:0015757","count":1},{"id":"GO:1990539","count":1},{"id":"GO:0006970","count":1},{"id":"GO:0015751","count":1}]},{"hash":"1905804039659277414","title":"Neural development and myelination","description":"This cluster is enriched for neural development and myelination terms (neurogenesis, nervous system development, myelination) along with muscle differentiation and broader developmental processes (somitogenesis, cardiac vascular smooth muscle development) and transcriptional regulation (RNA polymerase II\u2013mediated transcription, circadian regulation). The dominant theme ties to development of neural and muscle lineages, with transcriptional control as a core mechanism.","confidence":"High","size":13,"edges":52,"triangles":110,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0042552","count":5},{"id":"GO:0022008","count":5},{"id":"GO:0045663","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1995715832060985407","title":"RNA Splicing and Cell Cycle","description":"Enriched GO terms point to nuclear RNA processing (mRNA splicing via spliceosome, cis splicing) and transcription (DNA-templated), together with mitotic cell cycle and cell division. This suggests a cluster of proteins involved in RNA processing and regulation of cell proliferation. Some development-related terms (skin, brain) appear but are broad and likely secondary annotations. Overall, the core theme is RNA splicing linked to cell cycle regulation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0043588","count":3}]},{"hash":"733498431016232539","title":"Ubiquitin-Dependent Proteolysis and Signaling","description":"This cluster is dominated by GO terms for ubiquitination and ubiquitin-dependent protein catabolic processes (protein turnover), including protein ubiquitination and autoubiquitination. Additional terms point to ubiquitin\u2019s role in signaling pathways (regulation of JNK cascade, TNF signaling) and apoptosis, suggesting a cohesive theme around ubiquitin-mediated regulation of protein turnover and cell fate. Some immune and regulatory terms (adaptive immune response, vitamin D response, dosage compensation) reflect broader regulatory roles associated with ubiquitin systems, but the core pattern centers on ubiquitin-dependent proteolysis and related signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0016567","count":7},{"id":"GO:1903265","count":6},{"id":"GO:1903762","count":6},{"id":"GO:0051865","count":6}]},{"hash":"444020800681378080","title":"Central metabolism and quinone biosynthesis","description":"The top GO terms point to core energy and primary metabolism: several amino acid catabolic pathways (valine, alanine, phenylacetate), TCA cycle/2-oxoglutarate metabolism, and importantly the biosynthesis of quinones (phylloquinone, menaquinone) that function in the respiratory chain. While antibiotic biosynthesis is present, the dominant pattern emphasizes metabolism feeding energy production and redox cofactor assembly, justifying a label centered on central metabolism and quinone biosynthesis.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0009234","count":4},{"id":"GO:0006574","count":4},{"id":"GO:0010124","count":4},{"id":"GO:0006635","count":4}]},{"hash":"14780969255658061","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0071031","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0039702","count":4}]},{"hash":"1928763016752632545","title":"Viral Entry and Proviral Latency","description":"This cluster centers on steps by which viral elements enter host cells, integrate into the host genome, and establish latency. The prominent terms\u2014viral penetration into the host nucleus, DNA integration, and establishment of integrated proviral latency\u2014strongly point to a viral genome\u2013host interaction theme, with supporting DNA replication and recombination processes that facilitate genome maintenance and integration. Some terms also reflect host-symbiont interactions and apoptosis, which can occur in virus\u2013host dynamics.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0043137","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3}]},{"hash":"950396681978840252","title":"Embryogenesis and organogenesis","description":"The cluster\u2019s top GO terms point to developmental processes (in utero embryonic development, neuron maturation, multicellular organism growth, pancreas morphogenesis) and transcriptional regulation, suggesting these proteins collectively participate in embryonic tissue formation and organ development. Lipid metabolism signals (cholesterol efflux, fatty acid oxidation) may reflect metabolic regulation accompanying development but are less central to the core theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":6},{"id":"GO:0042551","count":6},{"id":"GO:0055114","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0035264","count":4}]},{"hash":"347924179834443650","title":"Cortical neuron development and axonogenesis","description":"Based on dominant GO terms such as cerebral cortex development, axonogenesis, and regulation of axon regeneration, the cluster appears to represent neural development and neurite/axon growth in cortical neurons. The presence of astral microtubule organization and regulation of cell polarity further supports cytoskeletal remodeling and polarity establishment needed for axon formation, while additional terms reflect broader cellular processes that are less central to the main theme.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030953","count":3},{"id":"GO:0021987","count":3},{"id":"GO:0097194","count":2},{"id":"GO:0010954","count":2},{"id":"GO:0071333","count":2}]},{"hash":"2094755175888296868","title":"Apoptosis and cellular stress responses","description":"The terms cluster around apoptotic processes in multiple cell types (glial, neuron, cardiac muscle) and cellular stress responses such as hypoxia, suggesting a shared theme of programmed cell death and stress signaling, with ancillary mentions of ribosome biogenesis and protein interactions.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0034349","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0051402","count":3},{"id":"GO:0070208","count":3}]},{"hash":"195747415939586385","title":"Photoreception and Visual Signal Transduction","description":"The dominant GO terms point to vision-related processes: visual perception, phototransduction, and regulation of opsin-mediated signaling, with calcium transport and dephosphorylation aligning with the phototransduction cascade. Some terms (heart development, myoblast fusion) seem less connected to vision and likely reflect broader, pleiotropic roles, but the core theme across the cluster is visual signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0007520","count":2},{"id":"GO:0007602","count":2},{"id":"GO:0071472","count":2}]},{"hash":"1816871223320257778","title":"ER-Golgi Transport and Lipid Homeostasis","description":"This cluster is dominated by GO terms for ER-to-Golgi vesicle transport, ER-associated degradation, and lipid regulation (SREBP signaling and cholesterol homeostasis), suggesting proteins involved in ER processing and lipid metabolism control. Additional terms like RNA methylation and actin capping appear peripheral, but the core theme ties ER trafficking to lipid homeostasis. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0051016","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0032933","count":3}]},{"hash":"1671761870710846471","title":"Central carbon metabolism and amino acid biosynthesis","description":"The cluster\u2019s top GO terms cluster around core metabolism: glycolysis, the TCA cycle, oxaloacetate metabolism, and biosynthetic pathways for amino acids and cofactors (lysine, biotin, porphyrin). Despite some obsolete terms, the shared theme is central carbon flux and biosynthesis, indicating a cohesive metabolic module rather than unrelated functions.","confidence":"High","size":13,"edges":72,"triangles":225,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":6},{"id":"GO:0006099","count":5},{"id":"GO:0006782","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0006351","count":3}]},{"hash":"1370159035934541462","title":"Bacterial metabolism and sporulation","description":"This cluster gathers GO terms across antibiotic biosynthesis, multiple metal and nutrient transports (iron, arsenate), lignin and cellulose catabolism, nitrate assimilation, and critical bacterial lifecycle processes such as FtsZ-dependent cytokinesis and sporulation. The connection point is microbial metabolism and lifecycle transitions, with sporulation/cytokinesis providing a cohesive bacterial-specific thread amid the diverse metabolic processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0030168","count":4},{"id":"GO:1901684","count":3},{"id":"GO:0046274","count":3}]},{"hash":"2192724230960325770","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043491","count":2},{"id":"GO:0006924","count":2},{"id":"GO:0006569","count":1},{"id":"GO:0043420","count":1},{"id":"GO:0034354","count":1}]},{"hash":"491083646657016156","title":"Membrane transport of ions and metabolites","description":"The top GO terms are dominated by various transmembrane transport activities (potassium ion, nitrate, sialic acid, vitamin transport) and vesicular processes (neurotransmitter loading into synaptic vesicles), which points to a core theme of membrane transport and trafficking. While a few terms (visual perception, ascospore formation, metanephric development) are unrelated to transport, the strongest and recurring signal across the cluster is transport across membranes and its role in neural signaling and sensory functions, suggesting the cluster groups proteins involved in membrane transport mechanisms.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0007601","count":2},{"id":"GO:0072205","count":2},{"id":"GO:0030437","count":2},{"id":"GO:0048168","count":2}]},{"hash":"1328262955445736312","title":"Unknown","description":"Top terms are heterogeneous, spanning cell cycle/DNA replication and diverse signaling or tissue-specific processes (androgen/insulin signaling, pain, axon regeneration, smooth muscle contraction). There is no single cohesive function linking these terms, so a unified label is not well-supported. None","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060765","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0007098","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0072428","count":2}]},{"hash":"1732869613660686954","title":"Neural development and axon guidance","description":"The top terms are dominated by nervous system development and neuron-specific processes (nervous system development, corticospinal tract morphogenesis, dopaminergic neuron axon guidance, sensory perception of sound, synaptic vesicle clustering), with a few cardiac-related outliers. This suggests the cluster centers on neural development and neural signaling rather than a broad mix of functions.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086073","count":1},{"id":"GO:0021957","count":1},{"id":"GO:0003273","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0036514","count":1}]},{"hash":"1923815230198006535","title":"Developmental and Neurovascular Signaling Cluster","description":"The GO terms point to developmental processes across tissues (kidney and spinal cord), together with vascular regulation (angiogenesis and vasoconstriction), immune complement activity, and neural signaling/memory (glutamatergic transmission and memory) plus thyroid hormone production. This suggests a broad developmental signaling cluster with neurovascular and endocrine aspects rather than a single, narrowly defined function.","confidence":"Medium","size":13,"edges":14,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0072218","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0021517","count":2},{"id":"GO:0016525","count":2}]},{"hash":"325954955745587806","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0097171","count":2},{"id":"GO:0009718","count":2},{"id":"GO:0009243","count":2},{"id":"GO:0009103","count":2}]},{"hash":"449993541524111037","title":"Auditory system development and epithelial adhesion","description":"The top terms point to inner-ear/cardiovascular or neural functions: sensory perception of sound, otolith tethering, and transmission of nerve impulse indicate auditory/vestibular roles. Concurrently, cell\u2013matrix adhesion and basement membrane\u2013related terms (cell-matrix adhesion, glomerular basement membrane development, integrin signaling) suggest a structural/adhesive context supporting these tissues. Calcium transport and integrin signaling further support tight coupling between adhesion and signaling in sensory structures. Some terms (triglyceride catabolic process, immune regulation) appear less related and may reflect broader or unrelated annotations. Overall, the cluster seems driven by inner-ear development and associated signaling and adhesion mechanisms.","confidence":"Medium","size":13,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090528","count":5},{"id":"GO:0007160","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0035889","count":3},{"id":"GO:0002853","count":3}]},{"hash":"518433428863590028","title":"Embryonic organogenesis and tissue morphogenesis","description":"The cluster\u2019s terms are dominated by embryonic development and tissue differentiation across multiple lineages (placental/trophoblast, cartilage, heart/em EMT, pancreas, brown fat, endocrine development, left-right patterning). A splicing term appears but the overall signal points to coordinated organogenesis and morphogenesis rather than a single molecular function, supporting a label focused on embryonic development themes.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2}]},{"hash":"2244051654896011601","title":"Vertebrate development and mechanotransduction","description":"The proteins share multiple GO terms tied to tissue development (telencephalon and skin) and to mechanical signaling and adhesion (cell-matrix adhesion, integrin signaling, response to muscle stretch, and regulation of heart contraction force). This pattern suggests a cluster of factors involved in development and in sensing/responding to mechanical cues across tissues. Some DNA replication/repair and hypoxia terms appear ancillary, but the core theme is development plus mechanotransduction.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0021537","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0098735","count":2},{"id":"GO:0043588","count":2}]},{"hash":"1519053769981023598","title":"Myelination and Paranode Axon Maintenance","description":"The dominant GO terms point to myelination and localization of proteins to the paranode region of axons, suggesting that this cluster centers on myelinated nerve fiber structure and axon\u2013glial interfaces; other terms reflect broader developmental and immune-modulatory processes but do not outweigh the neural paranode signal.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0043031","count":2},{"id":"GO:1904597","count":2},{"id":"GO:0060484","count":2}]},{"hash":"1874856665475928733","title":"Cell-cycle regulation and stress-response signaling","description":"This cluster features GO terms spanning cell cycle (GO:0007049) and various stress- and signaling-related processes (response to heat, regulation of kinase activity, calcium transport, endocytosis), suggesting proteins involved in coordinating cell cycle progression with cellular stress responses and signaling pathways. The terms are diverse and do not point to a single pathway, but the recurring themes of cell cycle and stress signaling provide a coherent, high-level label.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0002268","count":2}]},{"hash":"1317048756333094159","title":"MAPK and Growth Factor Signaling Regulators","description":"The cluster\u2019s top GO terms include ERK1/ERK2 cascade and EGFR signaling, which point to MAPK and growth factor\u2013driven signaling. Additional terms like regulation of extracellular matrix assembly, cardiac conduction, and angiotensin-related processes suggest broader regulatory roles linking signaling to cardiovascular and ECM contexts. Overall, the proteins appear to participate in signaling pathway regulation with a focus on MAPK/growth factor signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070371","count":2},{"id":"GO:2000266","count":1},{"id":"GO:1903779","count":1},{"id":"GO:0014067","count":1},{"id":"GO:0003051","count":1}]},{"hash":"1318436349679864955","title":"Unknown","description":"The top GO terms span diverse areas (fat body development, hemoglobin/heme metabolism, immune response, wound healing, various developmental processes, and neural/vascular development) with no clear single function tying the proteins together; plus there are no edges to suggest a cohesive module. This prevents a confident, specific label. ","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007505","count":2},{"id":"GO:0020027","count":2},{"id":"GO:0050900","count":2},{"id":"GO:2001268","count":2},{"id":"GO:0015886","count":2}]},{"hash":"2037752283518753130","title":"Immune and neuronal signaling regulators","description":"This cluster\u2019s top GO terms point to modulation of key signaling pathways across immune (MAPK cascade, T cell signaling, IL-6, TLR9) and neural contexts (axon regeneration, dendritic spine development, membrane depolarization). The shared theme is regulation of signaling activity in both immune and nervous systems, suggesting a cohesive role as regulators of signaling in these cell types.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":11},{"id":"GO:0000200","count":11},{"id":"GO:0050860","count":11},{"id":"GO:0048679","count":10},{"id":"GO:0034165","count":10}]},{"hash":"1701090258539663688","title":"Stress-Responsive Signaling and Transcription Regulation","description":"The GO terms point to calcium-calcineurin-NFAT signaling, nuclear import, transcription by RNA Pol II, hypoxia response, and autophagy, all of which connect signaling to transcriptional regulation under stress. Some terms about development (vascular morphogenesis, photoreceptor morphogenesis) may reflect broader regulatory programs but do not derail the core theme. Overall, this suggests a stress-responsive signaling and transcriptional control module.","confidence":"Medium","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051531","count":10},{"id":"GO:0006607","count":10},{"id":"GO:1903244","count":10},{"id":"GO:0006469","count":10},{"id":"GO:0071456","count":10}]},{"hash":"398266374356376596","title":"Neuronal development and apoptosis regulation","description":"The top terms concentrate on axonogenesis, axon regeneration, and establishment of cell polarity, which together point to neuronal morphogenesis and wiring. The presence of apoptosis-related terms (execution phase of apoptosis and regulation of programmed cell death) aligns with developmental pruning and neuron survival decisions. Metabolic signaling terms (glucose/insulin response, prostaglandin signaling) are present but appear secondary to the core neuronal development theme.","confidence":"High","size":12,"edges":12,"triangles":0,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097194","count":12},{"id":"GO:0010954","count":12},{"id":"GO:0071333","count":12},{"id":"GO:0048679","count":12},{"id":"GO:0071380","count":12}]},{"hash":"2096169573695357242","title":"Redox homeostasis and oxidative stress response","description":"This cluster is dominated by GO terms related to redox biology: cellular redox homeostasis, oxidation-reduction processes, cellular response to oxidative stress, and protein deglutathionylation, indicating a coordinated management of reactive oxygen species and redox balance. While a few terms are less aligned (methylamine metabolism, neural crest migration, and RNA polymerase II regulation), the strongest signal points to redox regulation and detoxification mechanisms.","confidence":"High","size":12,"edges":64,"triangles":201,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0045454","count":4},{"id":"GO:0030416","count":4},{"id":"GO:0098869","count":4},{"id":"GO:2000255","count":3}]},{"hash":"1319913877851952886","title":"Neural development and axon guidance signaling","description":"This cluster's top GO terms cluster around nervous system development, neurogenesis, myelination, axon guidance, and signaling pathways (Roundabout/Robo, Smoothened/Hedgehog), pointing to a cohesive theme of neural development and axon pathfinding. A single term about symbiont entry seems out of place and likely annotation noise, but does not obscure the overall neural-focused pattern.","confidence":"High","size":12,"edges":63,"triangles":192,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0045663","count":2},{"id":"GO:0035385","count":2},{"id":"GO:0048598","count":2}]},{"hash":"1436599128950292083","title":"Neural transcription regulation and redox signaling","description":"This cluster combines transcription-related terms (DNA-templated transcription, positive regulation of DNA binding, nuclear transport regulation) with neural development (axonogenesis) and redox biology (cell redox homeostasis, deglutathionylation, cytochrome complex assembly). The common thread appears to be redox-modulated transcriptional/signaling processes that influence neural differentiation and axon formation. Confidence: Medium.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0043388","count":6},{"id":"GO:0007409","count":5},{"id":"GO:0046826","count":5},{"id":"GO:0006351","count":5}]},{"hash":"971912670345032946","title":"Redox Detoxification and DNA Repair","description":"The cluster is dominated by GO terms related to oxidative stress management (cellular oxidant detoxification, redox homeostasis, glutathione metabolism) and DNA repair (nucleotide-excision repair), suggesting a cohesive role in protecting against oxidative damage and preserving genome integrity. Additional linked terms (response to estradiol, calcium signaling regulation, ERK cascade modulation) imply broader stress-response signaling, but redox detoxification and DNA repair are the most representative themes.","confidence":"High","size":12,"edges":63,"triangles":191,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":7},{"id":"GO:0045454","count":6},{"id":"GO:2000255","count":6},{"id":"GO:0060316","count":6},{"id":"GO:0014810","count":6}]},{"hash":"1975198225554114063","title":"T Cell Activation and Immune Signaling","description":"The cluster shows strong representation of T cell receptor signaling and thymic development terms (GO:0050852, GO:0043366), along with immune-stimulated responses such as GM-CSF signaling and LPS response (GO:0097011, GO:0071222). Additional terms related to transcriptional regulation (GO:0006351), Wnt signaling (GO:0090263), and ion transport (GO:0006813) suggest coordinated signaling and transcriptional control typical of T cell activation and differentiation. Confidence reflects a coherent immune-focused theme with some breadth due to related pathways\u2014Medium.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0097011","count":6},{"id":"GO:0071222","count":6},{"id":"GO:0006813","count":6}]},{"hash":"1768003978931333422","title":"Innate Gram-Positive Bacterial Defense & NF-\u03baB Signaling","description":"The cluster centers on innate immunity to bacteria, with terms for defense against Gram-positive bacteria, detection of bacteria, and positive regulation of canonical NF-\u03baB signaling, indicating components of bacterial sensing that activate NF-\u03baB-driven defense; related terms about host interaction and cell wall processes support this theme, though a few terms touch on general stress or wall remodeling.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0044117","count":2}]},{"hash":"168408008577875259","title":"RNA Processing and Transcription Machinery","description":"This cluster centers on RNA metabolism and transcription control: splicing and spliceosome assembly, rRNA and tRNA maturation/processing, histone mRNA metabolism, transcription termination, and mRNA decay. These functions collectively indicate a cohesive role in RNA maturation and gene-expression regulation, with some stress-related GO terms reflecting context-specific regulation under drought/ABA conditions.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":12},{"id":"GO:0030490","count":9},{"id":"GO:0009414","count":9},{"id":"GO:0009737","count":9},{"id":"GO:0008334","count":9}]},{"hash":"2014293658824412695","title":"Neuronal signaling and sensory perception","description":"The cluster is enriched for terms tied to neural activity and sensory processing, including regulation of membrane potential, dopamine receptor signaling, and acetylcholine metabolism, with a note of sensory perception of sound. While there are a few outlier terms related to development and immune response, the core signals point to neuronal communication and sensory function.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042391","count":2},{"id":"GO:0018298","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0070309","count":2}]},{"hash":"1556992722344472190","title":"Vertebrate Development and Differentiation","description":"The terms point to broad developmental roles across multiple vertebrate tissues (heart, gonads, cartilage, uterus, pituitary) and include regulation of transcription, actin dynamics, and apoptosis, suggesting a general developmental/differentiation program rather than a single pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0021983","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0006355","count":4}]},{"hash":"1382154595353941028","title":"Neural and cartilage development","description":"The GO terms cluster around developmental programs in neural tissues (brain development, inner ear development, neuron cell-cell adhesion, glial signaling) and skeletal/cartilage formation (cartilage development, embryonic skeletal system development, pituitary development), suggesting a cohesive theme of developmental processes across neural and skeletal systems.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051216","count":3},{"id":"GO:0007626","count":2},{"id":"GO:0048839","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0007158","count":2}]},{"hash":"1901525138183382833","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039702","count":2}]},{"hash":"1394002808060510531","title":"Metabolite Transmembrane Transporters","description":"The top GO terms are dominated by transmembrane transport of various small metabolites (glucose, biotin, myo-inositol, pantothenate) and sodium, indicating a cohesive theme of nutrient/ion transport across membranes. A few outlier terms (hypoxia response, rRNA maturation, apoptosis) are less consistent with this theme, suggesting they may be incidental annotations. ","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":3},{"id":"GO:0008292","count":2},{"id":"GO:0015878","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015798","count":2}]},{"hash":"494229835230212288","title":"Embryonic development and organ morphogenesis","description":"The top GO terms converge on developmental differentiation and morphogenesis across tissues: placenta and trophoblast differentiation, cartilage morphogenesis, endocrine and pancreatic development, left-right patterning, EMT in heart structures, and nervous system development. Although a couple terms like B cell receptor signaling and phototropism appear, the strongest signal is developmental patterning and organ formation, suggesting this cluster groups proteins involved in embryonic tissue specification and morphogenesis. Therefore the label reflects this central theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2}]},{"hash":"36661452702645368","title":"Neuronal sensory signaling and Na+ transport","description":"The cluster shows GO terms focused on sensory detection (temperature, mechanical, sour taste) and salt-related responses, plus sodium ion homeostasis and transmembrane transport, along with regulation of synaptic activity and neurotransmitter secretion. Taken together, these terms point to proteins involved in sensory neuron signaling and Na+-dependent ion transport/homeostasis, making this label representative despite one obsolete term. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050965","count":1},{"id":"GO:0071467","count":1},{"id":"GO:0035179","count":1},{"id":"GO:0035199","count":1},{"id":"GO:0055078","count":1}]},{"hash":"1348497738815279011","title":"Sterol and lipid biosynthesis","description":"This cluster is enriched for GO terms tied to lipid production and sterol metabolism: fatty acid biosynthetic process, ether lipid metabolic process, ergosterol biosynthetic process, cholesterol biosynthetic process via lathosterol, and related sterol oxidation steps. Additional terms reference lipid-rich tissues like myelin maintenance and sebaceous gland differentiation, which commonly involve lipid synthesis. Together these terms indicate a cohesive theme around synthesis and modification of sterols and lipids.","confidence":"Medium","size":12,"edges":16,"triangles":6,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":4},{"id":"GO:0046485","count":4},{"id":"GO:0006696","count":4},{"id":"GO:0032286","count":4},{"id":"GO:0033490","count":4}]},{"hash":"949147614981304417","title":"Immune signaling and hematopoietic development","description":"The cluster centers on immune regulation and blood cell formation: complement activation, Fc receptor signaling, NK T cell activation regulation, and IL-1 production modulation point to immune signaling; megakaryocyte development and myeloid progenitor differentiation indicate hematopoiesis; STAT phosphorylation relates to signaling pathways, with a few terms like AV node action potential suggesting broader signaling contexts. Overall, a cohesive theme of immune signaling intertwined with hematopoietic development emerges.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0006929","count":2},{"id":"GO:0042511","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0071656","count":2}]},{"hash":"26747243250238072","title":"DNA replication and mitosis","description":"The cluster is enriched for cell cycle and DNA replication terms: DNA replication, meiotic cell cycle, mitotic spindle\u2013kinetochore attachment, and mitotic checkpoint signaling, which together point to cell-cycle\u2013related functions. Some other terms appear less related (plant cell wall biosynthesis, adenosine biosynthesis, vascular branching, cocaine response, cardiac hypertrophy), likely reflecting broader or species-specific annotations, but the core signal supports a DNA replication/mitosis theme.","confidence":"High","size":12,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0051321","count":2},{"id":"GO:2001009","count":2},{"id":"GO:0051531","count":1},{"id":"GO:0046086","count":1}]},{"hash":"846566643255781140","title":"Neural development and synaptic signaling","description":"Based on the top GO terms, the cluster is enriched for nervous system development, neuron axon guidance, and synaptic vesicle clustering, including corticospinal tract morphogenesis and dopaminergic neuron guidance, as well as sensory perception of sound. These collectively point to neural development and synaptic organization as the core theme. A few terms (e.g., marginal zone B cell differentiation, indole-3-methanol response) appear as outliers, but they do not dominate the overall functional signal. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086073","count":2},{"id":"GO:0021957","count":2},{"id":"GO:0003273","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0036514","count":2}]},{"hash":"216484873273901710","title":"RNA Splicing Machinery","description":"This cluster\u2019s GO annotations are dominated by spliceosome and RNA splicing processes, including spliceosomal tri-snRNP complex assembly and mRNA processing; together they point to a core function in RNA maturation. A few additional terms related to apoptosis and inflammatory signaling are present but appear peripheral to the central RNA splicing theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000244","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0045292","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0097194","count":1}]},{"hash":"1465547536826504968","title":"Unknown","description":"The terms are a mix of developmental, signaling, ribosome biogenesis, spindle checkpoint, and several cell-wall related processes (peptidoglycan biosynthesis, cell wall organization, cell wall macromolecule catabolic process, chitin catabolic process) plus sporulation. There is no clear, unifying function connecting these terms across the 12 proteins, so a single coherent label cannot be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060037","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0000462","count":2},{"id":"GO:1901925","count":1},{"id":"GO:0071555","count":1}]},{"hash":"1447621254764495174","title":"Ubiquitin-Proteasome Proteostasis Regulation","description":"The cluster is dominated by GO terms tied to ubiquitin-related protein regulation (deubiquitination, autoubiquitination, proteasomal degradation regulation) and sumoylation, pointing to a core theme of maintaining protein homeostasis. Additional terms touch on translation and autophagy regulation, suggesting broader involvement in proteostasis and protein turnover, with a few outliers that may reflect related signaling roles. Overall, the strongest, most coherent signal is ubiquitin/SUMO-mediated control of protein degradation and turnover.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":6},{"id":"GO:1901799","count":5},{"id":"GO:1903265","count":5},{"id":"GO:0021888","count":5},{"id":"GO:0051865","count":5}]},{"hash":"1438796232808878440","title":"ER Quality Control and Receptor Endocytosis","description":"Several top GO terms point to ER-associated glycoprotein processing (mannose trimming in ERAD) and to membrane trafficking events (receptor internalization and receptor-mediated endocytosis). While other terms reflect general growth or metabolism, the strongest shared theme is protein maturation/quality control in the ER coupled with endocytic trafficking, suggesting this as the core function of the cluster.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904382","count":3},{"id":"GO:0016049","count":2},{"id":"GO:0098707","count":2},{"id":"GO:0010082","count":2},{"id":"GO:0007039","count":2}]},{"hash":"1180847478524605303","title":"Chitin metabolism and cuticle development","description":"Dominant terms are chitin catabolic process and chitin-based cuticle development, pointing to roles in chitin remodeling and exoskeleton formation. Some inflammatory signaling terms are present, but the core theme likely reflects chitin polysaccharide turnover and cuticle biosynthesis in the cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0090197","count":1}]},{"hash":"1312602570662358363","title":"ER stress\u2013driven vesicle transport and cytoskeleton dynamics","description":"The top GO terms cluster around translation initiation and reinitiation, microtubule-based movement, Golgi-to-ER vesicle transport, and ER-stress\u2013related apoptotic signaling, suggesting a cohesive theme of coordinating protein synthesis with vesicle trafficking and cytoskeleton dynamics under ER stress. While a couple of terms (development, platelet activation) are less directly connected, the strongest signal is ER stress\u2013associated trafficking and cytoskeleton regulation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0043547","count":2}]},{"hash":"8782018020881247","title":"Core energy metabolism and lipid biosynthesis","description":"These proteins cluster around core energy metabolism: glycolysis, TCA cycle, gluconeogenesis, and conversion of pyruvate to acetyl-CoA, plus malonyl-CoA\u2013driven fatty acid biosynthesis and amino-acid catabolism (lysine and leucine) feeding into acetyl-CoA. The link to sodium transport likely reflects associated energetic processes rather than a common pathway, but the dominant theme is central carbon metabolism and lipid biosynthesis.","confidence":"High","size":12,"edges":53,"triangles":141,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0033512","count":6},{"id":"GO:0019878","count":6},{"id":"GO:0006096","count":5},{"id":"GO:0006099","count":5},{"id":"GO:0042759","count":4}]},{"hash":"1488278727353062986","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":64,"triangles":200,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006450","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0015012","count":1},{"id":"GO:0030205","count":1}]},{"hash":"1806017467950384249","title":"Developmental signaling and cell death regulation","description":"This cluster combines developmental processes (spongiotrophoblast development, sensory organ precursor cell division, pancreatic cell proliferation), cell cycle aspect (chromosome segregation), and regulation of cell death (necroptosis, apoptosis regulation, ubiquitination) with signaling pathways (Wnt). This suggests proteins that coordinate development with controlled cell fate decisions and death pathways.","confidence":"Medium","size":12,"edges":10,"triangles":0,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902443","count":4},{"id":"GO:0060712","count":4},{"id":"GO:1902527","count":4},{"id":"GO:0007059","count":4},{"id":"GO:0070266","count":4}]},{"hash":"1496343353037549771","title":"Innate Immune Signaling and Macrophage Activation","description":"The cluster is driven by innate immune and macrophage-related terms: innate immune response, regulation of macrophage activation, and cell surface receptor signaling, with arachidonic acid\u2013related inflammatory signaling. A few terms about metabolism or development are likely secondary noise, but the dominant theme is innate immunity.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0043030","count":2},{"id":"GO:0090238","count":2},{"id":"GO:0007166","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0061298","count":2}]},{"hash":"157966664363208797","title":"Vacuolar proton transport and ion homeostasis","description":"These proteins cluster around vacuolar and proton-driven transport processes: multiple GO terms point to vacuole targeting, vacuolar acidification, and vacuole organization, as well as proton transmembrane transport and proton-motive-force\u2013driven ATP synthesis; plus copper and sodium ion homeostasis. The overall pattern is a functional theme of vacuolar/ion transport rather than mitochondrion-targeting or muscle regulation, despite a few unrelated terms present.","confidence":"Medium","size":12,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":1},{"id":"GO:0007035","count":1},{"id":"GO:0006878","count":1},{"id":"GO:0015991","count":1},{"id":"GO:0007033","count":1}]},{"hash":"280875406669296050","title":"Immune Signaling and Protein Turnover","description":"The cluster\u2019s top GO terms cluster around immune processes (T cell activation via TCR-MHC interaction) and proteostasis (ubiquitin-dependent protein catabolic process, proteasome assembly), with accompanying themes of cell adhesion and development. This suggests a shared focus on immune signaling coupled with regulation of protein turnover, even though some terms reflect broader developmental processes or coagulation. Overall, the most coherent theme centers on immune-related signaling intertwined with proteolytic regulation.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0007596","count":9},{"id":"GO:0006511","count":8},{"id":"GO:0002291","count":8},{"id":"GO:0007161","count":8},{"id":"GO:0031104","count":8}]},{"hash":"1057787708287383073","title":"RNAP II Transcription Regulation","description":"This cluster is dominated by GO terms pointing to RNA polymerase II\u2013mediated transcription regulation (negative regulation of RNAP II regulatory region DNA binding, negative regulation of transcription by RNAP II, DNA-templated transcription, and DNA binding). While there are unrelated terms related to redox/oxidative stress and ER folding, the transcription control terms are the most prominent, suggesting a core role in RNAP II\u2013driven transcription regulation.","confidence":"Medium","size":12,"edges":13,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0043388","count":1}]},{"hash":"504188084955587432","title":"Developmental and Immune Regulation","description":"Developmental and Immune Regulation is chosen because the terms cover embryonic development and tissue morphogenesis (lung epithelium, melanocyte differentiation, cuticle-related processes), alongside immune-related regulation (TNF production, complement activation, dendritic cell antigen processing). This points to a broad role in development with concurrent immune/modulatory functions, rather than a single pathway or tissue-specific function.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0033564","count":1},{"id":"GO:1901509","count":1},{"id":"GO:0010751","count":1},{"id":"GO:0060481","count":1}]},{"hash":"26982210950830895","title":"Ubiquitin-Dependent Proteolysis Regulators","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic process and negative regulation of protein ubiquitination, suggesting these proteins function in ubiquitin-mediated protein turnover. While some terms touch on development and immune-related processes, the unifying theme appears to be regulation of ubiquitin-proteasome\u2013mediated protein degradation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0007399","count":4},{"id":"GO:0009638","count":4},{"id":"GO:0035914","count":4},{"id":"GO:0002467","count":4}]},{"hash":"115497159556994480","title":"Neural differentiation and mitotic cytoskeleton dynamics","description":"The cluster centers on cytoskeletal/microtubule processes essential for cell division (cell cycle, microtubule nucleation, FtsZ/cytokinesis, cell division) and protein polymerization, with additional terms pointing to neural development and mechanosensory regulation. This suggests a cohesive theme of cytoskeleton-driven mitosis in a neural development context, justifying the label.","confidence":"Medium","size":11,"edges":29,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":8},{"id":"GO:1905792","count":8},{"id":"GO:0007020","count":8},{"id":"GO:2000767","count":8},{"id":"GO:0030182","count":8}]},{"hash":"1819883682612009995","title":"Steroid, retinoid, and secosteroid biosynthesis","description":"This cluster shows a coherent theme of biosynthesis for signaling molecules: multiple steroid hormones (cortisol, aldosterone, progesterone), a secosteroid (calcitriol), and a retinoid (9-cis-retinoic acid). The presence of the epoxide-forming P450 pathway and related metabolism, plus a note on sex differentiation, supports a hormone- and lipid-signaling\u2013focused set of functions rather than unrelated catabolic or structural processes. Confidence in this label is high.","confidence":"","size":11,"edges":15,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019383","count":3},{"id":"GO:2001037","count":3},{"id":"GO:0042904","count":3},{"id":"GO:0032342","count":3},{"id":"GO:0010193","count":3}]},{"hash":"2166917329800678388","title":"Thermal Stress Signaling with Ion Transport","description":"The cluster centers on responses to temperature and metabolic cues (temperature stimulus, diet-induced thermogenesis) and links these to cellular signaling pathways (cAMP signaling, GTPase activity regulation, guanylyl cyclase signaling). Ion transport terms (sodium import, potassium export) further tie the response to ionic changes across membranes, suggesting a theme of temperature/metabolic sensing coupled to signaling and ion flux. Some terms like pain perception and heart development appear as outliers, likely reflecting broad annotations rather than core function of this cluster.","confidence":"Medium","size":11,"edges":13,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0002024","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0043547","count":4}]},{"hash":"346047012673921322","title":"Detox and Redox Stress Metabolism","description":"This cluster\u2019s terms include diverse metabolic processes (retinol/retinal, arabinose catabolism, glutathione biosynthesis, lactone and progesterone metabolism) but are strongest in stress and redox-related activities (response to cadmium, water deprivation, tissue homeostasis, oxidation-reduction). Together they point to a module focused on redox balance and detoxification under stress, with metabolic context.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":11},{"id":"GO:0042574","count":11},{"id":"GO:0009414","count":9},{"id":"GO:0070485","count":9},{"id":"GO:0001894","count":9}]},{"hash":"2218317703660258743","title":"ER-Golgi trafficking and inflammatory mediators","description":"GO terms point to two themes: ER-Golgi transport and inflammatory signaling. COPI coating of Golgi vesicles, protein retention in the ER lumen, and positive regulation of protein exit from the ER suggest a secretory/trafficking role, while production of molecular mediators and positive regulation of chemokine production reinforce an inflammatory angle. Some terms (chitin catabolic process, placenta development, amyloid-beta regulation) are less clearly connected, likely reflecting broader annotations, but they do not negate the core pattern.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0090197","count":1},{"id":"GO:0048205","count":1}]},{"hash":"298050889759140351","title":"Embryonic organ morphogenesis and metabolism","description":"Top GO terms suggest involvement in embryonic development of digestive tract, eye, inner ear, and vasculature, with retinoic acid signaling and various metabolic processes, indicating proteins linked to early organ formation and metabolic activity.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048566","count":10},{"id":"GO:0042904","count":10},{"id":"GO:0019544","count":10},{"id":"GO:0015976","count":10},{"id":"GO:0031076","count":10}]},{"hash":"745144477880413091","title":"Unknown","description":"There are no GO terms provided to guide a functional label, so no clear shared theme can be inferred from this cluster despite its dense connectivity.","confidence":"","size":11,"edges":49,"triangles":119,"max_degree":10,"top_function":null,"top_go_terms":[]},{"hash":"655857374693518871","title":"Unknown","description":"GO terms span redox processes, immune cytotoxicity, reproduction, lipoprotein biosynthesis, and signaling with no single cohesive function, making a representative label unreliable.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0017004","count":1},{"id":"GO:0019430","count":1},{"id":"GO:0042267","count":1},{"id":"GO:0007283","count":1}]},{"hash":"510421145756891304","title":"Neural MAPK Signaling and Stress Response","description":"This cluster centers on MAPK pathways, with GO terms for p38MAPK and ERK cascades and responses to phorbol esters, along with transcriptional regulation. The presence of nervous system development and axon regeneration terms suggests a neural context where MAPK signaling influences survival, differentiation, and repair, possibly linking stress signals to gene expression and apoptosis. ","confidence":"High","size":11,"edges":25,"triangles":27,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1904628","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0038066","count":2},{"id":"GO:0070371","count":2}]},{"hash":"2167979353893817279","title":"Axonogenesis and apoptosis regulation in neural development","description":"The terms cluster around neural development processes: axonogenesis and regulation of axon regeneration, establishment of cell polarity, and apoptosis control (execution phase and programmed cell death). Additional terms related to cellular responses to prostaglandin E and glucose signaling suggest metabolic and signaling cues that modulate neural growth and survival. Together, these indicate a cohesive theme of neural development with coordinated growth and survival signaling.","confidence":"Medium","size":11,"edges":12,"triangles":3,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097194","count":11},{"id":"GO:0010954","count":11},{"id":"GO:0071333","count":11},{"id":"GO:0048679","count":11},{"id":"GO:0071380","count":11}]},{"hash":"638108096964017347","title":"Signaling, stress, and growth regulators","description":"This cluster contains GO terms that revolve around regulation of signaling pathways (notably cAMP/PKA activity), cellular stress responses (ER stress\u2013related apoptosis), metabolism (glycolysis regulation), and growth-related processes (stem cell proliferation and blood vessel branching), plus related regulatory activities (protein destabilization, histone modification, and differentiation). The mix suggests proteins that serve as regulators of signaling and cellular fate under stress or growth conditions, rather than a single concrete pathway. ","confidence":"Medium","size":11,"edges":21,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:2000481","count":4},{"id":"GO:1902237","count":3},{"id":"GO:0045650","count":3},{"id":"GO:2000480","count":2},{"id":"GO:0071572","count":2}]},{"hash":"1446495470432664652","title":"mRNA splicing and translational regulation","description":"This cluster is enriched for spliceosome-mediated mRNA processing (cis splicing, alternative splicing), mRNA stability regulation, ncRNA-mediated gene silencing, and components of translation initiation. Together these terms point to coordinated post-transcriptional control of mRNA maturation and translation, suggesting a cohesive function in RNA processing and protein synthesis.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0010610","count":9},{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0060211","count":8}]},{"hash":"852629301427023899","title":"GPCR Signaling in Cardiovascular and Immune Regulation","description":"The top GO terms converge on GPCR-mediated signaling (dopamine receptor signaling, GPCR pathway regulation, acetylcholine metabolism, prostaglandin response) and cardiovascular processes (renin-angiotensin regulation, vascular smooth muscle differentiation), with immune-related terms (cytolysis, IL-1 beta production) also present. This points to a coherent cluster centered on GPCR-driven communication that links cardiovascular regulation with immune signaling, though a distant development term appears as an outlier. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":9},{"id":"GO:0007195","count":9},{"id":"GO:0060408","count":9},{"id":"GO:0007497","count":9},{"id":"GO:0006955","count":9}]},{"hash":"1409454651465342359","title":"Developmental signaling and morphogenesis","description":"The cluster features GO terms tied to development and morphogenesis across tissues (axonogenesis, photoreceptor morphogenesis, blood vessel branching) along with signaling regulation (NFAT/calcineurin, kinase activity) and stress responses (hypoxia, autophagy). This suggests a broad theme of developmental signaling and morphogenic processes rather than a single specific pathway, justifying a label centered on development and morphogenesis.","confidence":"Medium","size":11,"edges":13,"triangles":10,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051531","count":11},{"id":"GO:0006607","count":11},{"id":"GO:1903244","count":11},{"id":"GO:0006469","count":11},{"id":"GO:0071456","count":11}]},{"hash":"596469601170315622","title":"Telomere maintenance regulation and capping","description":"This cluster is dominated by GO terms about telomere maintenance (including regulation via telomerase and telomere lengthening), telomere capping, and telomeric DNA binding, suggesting a core theme of telomere integrity regulation. Other terms touch on broader DNA-related processes (PARylation) and cell-cycle contexts (spindle assembly), but the telomere-focused terms are the strongest signal.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070212","count":6},{"id":"GO:0070198","count":5},{"id":"GO:1904357","count":5},{"id":"GO:0032212","count":5},{"id":"GO:0051225","count":5}]},{"hash":"269502324936030062","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0001731","count":3}]},{"hash":"2004327200744519296","title":"Transmembrane Ion and Sugar Transporters","description":"The top GO terms are dominated by transmembrane transport of multiple ions (potassium, sodium, phosphate, sialic acid) and sugars (galactose, fructose, arabinose), pointing to a group of membrane transporter proteins with broad substrate specificity. Additionally, mentions of cellular responses to glucose starvation and osmotic stress align with transporter activity under stress conditions. Despite no reported interactions, the cohesive theme is a transporter-centric cluster.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0042149","count":2},{"id":"GO:0015757","count":2},{"id":"GO:1990539","count":2}]},{"hash":"2202167895304056607","title":"Eye morphogenesis and lens development","description":"The cluster is dominated by GO terms tied to eye development, notably camera-type eye development, embryonic eye morphogenesis, and lens epithelial cell proliferation, with supporting transcription-related terms, suggesting a coherent group of proteins functioning in eye and lens formation.","confidence":"High","size":11,"edges":46,"triangles":101,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0031018","count":6},{"id":"GO:0071353","count":4},{"id":"GO:0035470","count":4},{"id":"GO:0006351","count":4}]},{"hash":"134805253357659549","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning insulin and islet peptide processing, various transport and catabolic processes, embryonic and larval development, and several reproductive-related activities (sperm capacitation, sperm-zona binding, hatching behavior). This lack of a clear, cohesive biological theme across the cluster makes it difficult to assign a single, representative function label. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030070","count":2},{"id":"GO:0043252","count":2},{"id":"GO:0048566","count":1},{"id":"GO:0042089","count":1},{"id":"GO:0035187","count":1}]},{"hash":"1269232594587263663","title":"Exocytosis and Golgi vesicle trafficking","description":"These proteins are strongly linked to vesicle trafficking and exocytosis, including SNARE-mediated fusion, Golgi transport to the plasma membrane, and synaptic vesicle exocytosis, with also NK cell degranulation. The common theme is regulated vesicle fusion and trafficking through the Golgi-to-membrane pathway, spanning neuronal and immune cell contexts.","confidence":"High","size":11,"edges":40,"triangles":72,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":7},{"id":"GO:0035493","count":7},{"id":"GO:0098967","count":7},{"id":"GO:0006891","count":7},{"id":"GO:0006888","count":7}]},{"hash":"2153179000399352437","title":"Mitotic Progression and Proteasome-Mediated Degradation","description":"The top GO terms center on mitosis and chromosome segregation (G2/M transition, exit from mitosis) and the SCF-dependent ubiquitin-proteasome degradation pathway, indicating a coherent mitotic control and protein turnover program. While DNA repair and other processes appear, the dominant theme is cell-cycle regulation intertwined with proteasomal activity, suggesting the cluster reflects mitotic progression with regulated proteolysis.","confidence":"High","size":11,"edges":52,"triangles":141,"max_degree":10,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0007059","count":11},{"id":"GO:0031146","count":11},{"id":"GO:0070911","count":11},{"id":"GO:0016032","count":11},{"id":"GO:0000086","count":11}]},{"hash":"2053854027076773006","title":"Glycolysis and Carbohydrate Metabolism","description":"The top GO terms cluster around glycolysis and carbohydrate processing, including canonical glycolysis, glycolysis from storage polysaccharide through glucose-1-phosphate, fructose-6-phosphate metabolism, and glycogen catabolic processes, with carbohydrate phosphorylation highlighting energy-yielding steps. Additional terms for biotin and antibiotic biosynthesis point to broader metabolic biosynthesis tied to carbohydrate metabolism. Overall, the dominant signal is glycolytic energy metabolism.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":4},{"id":"GO:0061621","count":2},{"id":"GO:0093001","count":2},{"id":"GO:0006002","count":2},{"id":"GO:0005980","count":2}]},{"hash":"1554218576904339344","title":"Cardiac contraction and calcium signaling","description":"The terms strongly cluster around cardiac muscle function: myofibril assembly, regulation of cardiac muscle contraction, muscle relaxation, and calcium ion release into the cytosol, pointing to a theme of cardiomyocyte contractility and calcium handling. Some other terms (retina layer formation, transcription regulation, oxidative processes) are present but less representative of the core function. ","confidence":"High","size":11,"edges":17,"triangles":11,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000678","count":9},{"id":"GO:0055003","count":9},{"id":"GO:0035191","count":9},{"id":"GO:0086004","count":9},{"id":"GO:0042994","count":9}]},{"hash":"1677420434116530079","title":"Actin Cytoskeleton Remodeling and Signaling","description":"This cluster is enriched for actin-based remodeling processes (stress fiber and filopodium assembly, substrate adhesion-dependent spreading) and regulatory signaling (ubiquitination, ERK1/2 cascade), indicating coordinated cytoskeletal dynamics and signal transduction. The inclusion of mitochondrial fission and neuronal GABAergic transmission suggests broader links between cytoskeletal changes, organelle dynamics, and synaptic signaling, including mechanosensation-related processes. ","confidence":"Medium","size":11,"edges":9,"triangles":0,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0033138","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0043149","count":5},{"id":"GO:0050975","count":5}]},{"hash":"1241053198685701381","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0055114","count":2},{"id":"GO:0006212","count":2},{"id":"GO:0019740","count":2},{"id":"GO:0045984","count":2}]},{"hash":"160637649119274638","title":"Growth, gene expression, and secretory trafficking","description":"Top GO terms point to core cellular processes: DNA-templated transcription and ribosome biogenesis (gene expression), cell division and growth, and essential vesicle trafficking from ER to Golgi (COPII-coated vesicles). Although brain development is listed, it likely reflects differentiation-linked growth that depends on protein synthesis and secretion. The combination suggests a cluster centered on fundamental growth and protein-manufacturing pathways with an active secretory transport component.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0043966","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006351","count":3}]},{"hash":"97142263903087821","title":"Organelle biogenesis and vesicle trafficking","description":"Best label reflects a cluster rich in processes tied to organelle assembly and intracellular trafficking, including melanosome assembly, regulation of exocytosis and exosome secretion, Cvt pathway targeting, and actin-mediated vesicle movement. While some terms touch development (cochlea/kidney size/macrophage differentiation) or ribosome biogenesis, the strongest shared thread is organelle biogenesis and vesicle trafficking.","confidence":"Medium","size":11,"edges":13,"triangles":0,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0090103","count":2},{"id":"GO:0030838","count":2},{"id":"GO:1903542","count":2},{"id":"GO:2000300","count":2}]},{"hash":"814479870365327928","title":"Viral integration and host innate immune signaling","description":"This cluster centers on viral entry and genome integration processes (DNA transposition, retrotransposition, integrated proviral latency, DNA integration) and host defense modulation (regulation of toll-like receptor signaling, apoptosis activation, ubiquitination, and cell cycle regulation). The co-occurrence of these related GO terms suggests a theme of virus\u2013host genome interactions together with innate immune responses, rather than a single enzyme class.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0034121","count":4},{"id":"GO:0000209","count":4},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0032197","count":3}]},{"hash":"253921200573340577","title":"Sodium-phosphate transport and metal ion response","description":"The cluster shows GO terms centered on sodium-dependent phosphate transport and its positive regulation, integrated with terms for metal ion responses (arsenate, lead, mercury). This suggests a theme around transport of phosphate coupled with cellular responses to metal ions, even though a few terms (like GTPase regulation and antibiotic/metabolism terms) are less coherent with the core pattern. Overall, the most representative shared function appears to be ion transport and metal stress response.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":2},{"id":"GO:1901684","count":1},{"id":"GO:2000120","count":1},{"id":"GO:0010288","count":1},{"id":"GO:0046689","count":1}]},{"hash":"968933569520372329","title":"Stress Response and Metabolic Signaling","description":"The cluster features GO terms for response to xenobiotic stimulus and stress, glucose starvation, and signaling (Wnt), along with regulation of mRNA stability and nucleotide/metabolic salvage processes, suggesting a cohesive theme of stress-responsive signaling linked to metabolic regulation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0043488","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2}]},{"hash":"1113309920297229828","title":"Ubiquitin-Proteasome Regulation & Circadian Rhythm","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic processes and SCF-dependent ubiquitination, indicating a strong link to proteostasis via the ubiquitin-proteasome system. The concurrent enrichment for regulation of circadian rhythm suggests these proteins may coordinate protein turnover with daily cycles. While other terms touch on metal stress or synapse components, the core theme is ubiquitin-mediated proteolysis with circadian regulation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0031146","count":4},{"id":"GO:0042752","count":4},{"id":"GO:1902916","count":3},{"id":"GO:0046685","count":3}]},{"hash":"1716952648992084970","title":"Ribosome Biogenesis and Cell Growth","description":"The top terms cluster around ribosome biogenesis and related translation machinery (ribosome biogenesis, small subunit biogenesis, tRNA modification) together with cell cycle and septum assembly, suggesting a core group of proteins involved in growth and division. Metabolic terms like glucose catabolic process hint at energy provisioning for these biosynthetic activities, reinforcing the growth-related theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0006400","count":2},{"id":"GO:0000747","count":2},{"id":"GO:1901001","count":2},{"id":"GO:0039707","count":2}]},{"hash":"158675066694516611","title":"Ribosome biogenesis and cell division","description":"This cluster is dominated by GO terms related to ribosome assembly and translation (tRNA modification; ribosome biogenesis; ribosomal small subunit biogenesis), suggesting a core translation machinery theme. It also includes cell cycle and cell septum assembly terms, indicating coordination with cell division. Although some metabolic and stress-related terms appear, the strongest signal ties protein synthesis capacity to cell division, supporting a growth/proliferation cluster.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006400","count":8},{"id":"GO:0007049","count":8},{"id":"GO:0000747","count":8},{"id":"GO:1901001","count":8},{"id":"GO:0039707","count":8}]},{"hash":"1356183535606890180","title":"Neuronal axon guidance and synapse formation","description":"The terms converge on neuronal connectivity: retinal ganglion cell axon guidance, motor neuron axon fasciculation, dendritic spine morphogenesis, synapse assembly, and ephrin signaling point to axon pathfinding and synaptogenesis, with adhesion and ERK/MAPK pathway involvement indicating downstream signaling in these processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0043654","count":3}]},{"hash":"2093514016037212534","title":"Unknown","description":"The top GO terms show a wide and diverse set of processes\u2014neuromuscular posture, skeletal muscle differentiation, hormone biosynthesis regulation, protein sumoylation, IL-1\u03b2 production, estrous cycle, heparin response, mesangial cell proliferation, ischemia response, and insulin response\u2014without a single cohesive function tying them together. This heterogeneity suggests there isn\u2019t a clear, shared theme for this cluster, so the label Unknown is most appropriate. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":2},{"id":"GO:0046886","count":1},{"id":"GO:0035914","count":1},{"id":"GO:0033233","count":1},{"id":"GO:0050725","count":1}]},{"hash":"285343197770967112","title":"DNA Transcription and Cell Cycle in Development","description":"This cluster centers on DNA-templated transcription and key cell cycle processes (G1/S transition, mitotic checkpoints, cell division), with several development-associated terms across tissues. The co-occurrence of transcription regulation and cell cycle terms suggests a theme of transcriptional control coupled to proliferation during development, making this a coherent label despite some diverse outliers.","confidence":"Medium","size":10,"edges":18,"triangles":6,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0060749","count":4},{"id":"GO:0033327","count":4},{"id":"GO:0071481","count":3},{"id":"GO:0000082","count":3}]},{"hash":"138232586616500911","title":"Mitosis and Chromosome Segregation","description":"The cluster centers on cell division with processes like centromeric CENP-A chromatin assembly, microtubule dynamics (severing and movement), and DNA repair by homologous recombination, all key to chromosome maintenance and spindle-driven segregation during mitosis; vesicle trafficking terms may reflect division-related membrane remodeling as a broader cellular context.","confidence":"High","size":10,"edges":21,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0061641","count":2},{"id":"GO:0051260","count":2}]},{"hash":"117090907396964566","title":"Embryonic and Organ Morphogenesis","description":"The cluster centers on embryonic development and organ morphogenesis across multiple tissues (eye, pancreas, prostate, ovary, heart), with related growth and differentiation terms. This suggests a cohesive developmental program rather than a single tissue-specific function, justifying the Embryonic and Organ Morphogenesis label.","confidence":"High","size":10,"edges":10,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0001701","count":5},{"id":"GO:0001547","count":4},{"id":"GO:0042753","count":4}]},{"hash":"1790229363376691359","title":"Fungal secretory pathway and cell wall biosynthesis","description":"The top terms highlight fungal-type beta-glucan biosynthesis and protein targeting to membranes (SRP-dependent cotranslational and post-translational), which together indicate secretion and membrane trafficking feeding cell wall assembly. While there are miscellaneous terms for DNA replication, iron-sulfur cluster assembly, and apoptosis regulation, the most coherent signal is secretory/membrane targeting linked to fungal cell wall biosynthesis.","confidence":"Medium","size":10,"edges":15,"triangles":1,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000902","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0046827","count":3},{"id":"GO:0070880","count":3},{"id":"GO:0006880","count":3}]},{"hash":"1018752994770797185","title":"Unknown","description":"The cluster's top GO terms span gas vesicle organization, vesicle transport, ribosome assembly, cilium movement, DNA replication/transcription, signaling, protein catabolic processes, and photosynthesis. This broad mix includes both prokaryotic and eukaryotic processes with no single unifying function, making a cohesive label unlikely. ","confidence":"","size":10,"edges":13,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031412","count":6},{"id":"GO:1990048","count":6},{"id":"GO:0000027","count":6},{"id":"GO:0003341","count":6},{"id":"GO:0006260","count":5}]},{"hash":"11537094154905075","title":"Cerebellar development and neural regeneration","description":"The cluster\u2019s top GO terms strongly emphasize cerebellar neurodevelopment (cerebellar cortex formation; Bergmann glial cell differentiation) and neural repair processes (regulation of axon regeneration). While insulin receptor signaling appears, and there are immune signaling terms, the cerebellar development and regeneration theme best captures the prevalent functions across the proteins. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0048679","count":9},{"id":"GO:2001275","count":9},{"id":"GO:0008286","count":9},{"id":"GO:0008285","count":9},{"id":"GO:0021697","count":9}]},{"hash":"525553326552654564","title":"Axonogenesis and apoptosis regulation","description":"The top terms include axonogenesis and regulation of axon regeneration, indicating neuronal growth/guidance. There are clear apoptosis-related terms (execution phase of apoptosis, positive regulation of programmed cell death), signaling a role in cell survival/death control. Additional terms related to prostaglandin E and glucose stimulus suggest broader signaling contexts, but the dominant themes point to neural development and survival signaling.","confidence":"Medium","size":10,"edges":19,"triangles":11,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097194","count":10},{"id":"GO:0010954","count":10},{"id":"GO:0071333","count":10},{"id":"GO:0048679","count":10},{"id":"GO:0071380","count":10}]},{"hash":"7350334670158435","title":"Cardiovascular GPCR-cAMP signaling cluster","description":"The strongest signals are in blood pressure regulation and GPCR-cAMP signaling: positive regulation of blood pressure, activation/inhibition of adenylate cyclase, and pathways linked to renin-angiotensin and dopamine receptor signaling, plus acetylcholine metabolism and prostaglandin responsiveness. This points to a cohesive theme of cardiovascular hormonal signaling and second-messenger (cAMP) control. Electron transport chain and immune response terms are present but primary relevance appears to cardiovascular signaling networks.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0007190","count":9},{"id":"GO:0001991","count":8}]},{"hash":"491622462233601190","title":"Prostaglandin-driven vascular and inflammatory signaling","description":"The cluster features strong representation of prostaglandin biosynthesis and vascular processes (endothelial adhesion, vasoconstriction, coagulation) plus inflammatory responses (lipopolysaccharide and pain). Some terms relate to vitamin D signaling, gonad and retina development, but the dominant pattern is prostaglandin-associated vascular and inflammatory regulation.","confidence":"Medium","size":10,"edges":3,"triangles":1,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0008585","count":4},{"id":"GO:0001516","count":4},{"id":"GO:0071603","count":4},{"id":"GO:0045986","count":3}]},{"hash":"1887742304070287493","title":"Neuronal amino acid transport and GABA synthesis","description":"The top GO terms point to transport of several amino acids (glutamate, serine, threonine, D-aspartate) across membranes and GABA biosynthesis, which together suggest neuronal amino acid handling and neurotransmitter metabolism. The inclusion of transmembrane transport and brain-related terms like prostaglandin response and brain renin-angiotensin system further supports a neural context. This cluster is best described as brain-relevant amino acid transport and GABA-related function.","confidence":"Medium","size":10,"edges":37,"triangles":69,"max_degree":9,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0009449","count":3},{"id":"GO:0015826","count":3},{"id":"GO:0051938","count":3},{"id":"GO:0032329","count":3}]},{"hash":"1194036471493920404","title":"Hepatic lipid metabolism and mitochondrial energy","description":"Based on the GO terms, the proteins are linked to lipid metabolism (cholesterol metabolism, fatty acid beta-oxidation, acetyl-CoA/propionyl-CoA pathways) and mitochondrial energy processes, with a liver-focused context (liver development) and hormonal regulation. This suggests a cohesive cluster centered on liver-associated lipid catabolism and mitochondrial energy production. ","confidence":"Medium","size":10,"edges":34,"triangles":62,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":6},{"id":"GO:0008203","count":4},{"id":"GO:0009725","count":4},{"id":"GO:0006550","count":4},{"id":"GO:0019619","count":4}]},{"hash":"1511943633057422418","title":"Embryonic development and signaling","description":"The cluster is dominated by developmental GO terms (heart, forebrain, skeletal system development, neural tube closure), suggesting roles in embryogenesis and tissue patterning. Additional terms point to transcriptional regulation (DNA-templated transcription) and signaling pathway modulation (negative regulation of canonical Wnt signaling), consistent with coordinated development and cell proliferation (mitotic cell cycle). A few terms like T cell receptor signaling and response to toxic substances are less directly tied but may reflect broader signaling roles or annotation noise, yet the overall theme remains developmental and signaling-centered.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0009636","count":5},{"id":"GO:0051436","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0001501","count":4}]},{"hash":"2021078740914378345","title":"Immune and neuronal signaling regulators","description":"The proteins span several immune-related signaling pathways (ERBB2 signaling, T cell receptor signaling, Toll-like receptor signaling, ERK cascade regulation, IL-6 production) and neuronal processes (axon regeneration, dendritic spine development, membrane depolarization). This suggests they act as regulators of broad signal transduction with roles in both immune and nervous system contexts.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038128","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0070373","count":1},{"id":"GO:0048679","count":1},{"id":"GO:0034165","count":1}]},{"hash":"1785511275740675909","title":"Sulfur metabolism and tRNA thiolation","description":"The terms converge on sulfur biology: transsulfuration, redox homeostasis, tRNA wobble uridine thiolation, urmylation, and molybdenum cofactor biosynthesis\u2014all sulfur- or sulfur-cofactor\u2013related processes. A couple of terms about development or cell cycle are likely annotation noise, but the core appears to be sulfur trafficking and sulfur-dependent modification pathways.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0018192","count":2},{"id":"GO:0019346","count":2},{"id":"GO:0032447","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0035335","count":2}]},{"hash":"1048217127073247401","title":"MAPK and TGF\u03b2 Signaling Regulators","description":"The cluster is enriched for GO terms around MAPK pathway regulation (JNK, p38), cellular response to TGF-\u03b2, and apoptosis, with additional signals about GTPase activity and development. Despite some outliers, the dominant theme is signaling regulation in stress and developmental contexts leading to apoptosis, so a label reflecting MAPK/TGF-\u03b2\u2013mediated signaling and cell death is appropriate.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0002035","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0016998","count":2},{"id":"GO:0007507","count":2}]},{"hash":"630985114893841252","title":"Unknown","description":"The GO terms span many unrelated areas (visual learning, spermatogenesis, various negative regulations) with little common functional thread, so there is no coherent theme tying these proteins into a single, interpretable cluster function.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0018298","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0040015","count":2},{"id":"GO:0045019","count":1}]},{"hash":"1968809866498059732","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning nitrogen/nitrate metabolism, sterol and lipid biosynthesis, mitochondrial inheritance, and various development/differentiation processes across different cell types and organisms. There isn\u2019t a single coherent biological theme linking these terms, so a simple, unified label is not apparent.","confidence":"","size":10,"edges":16,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0006809","count":3}]},{"hash":"2108483049811721555","title":"Cardiovascular and skeletal muscle development","description":"The GO terms center on heart formation, skeletal muscle differentiation, and endothelial cell migration in angiogenesis, suggesting a developmental theme focused on mesoderm-derived tissues (heart, muscle, and vasculature). Other terms touch on signaling and protein processing but do not override this common developmental thread. Overall, proteins appear linked to formation and differentiation of cardiac, muscular, and vascular tissues rather than housekeeping functions.","confidence":"Medium","size":10,"edges":11,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":1},{"id":"GO:0006487","count":1},{"id":"GO:0035307","count":1},{"id":"GO:0046827","count":1},{"id":"GO:0035414","count":1}]},{"hash":"1366094942044931907","title":"Innate defense against Gram-positive bacteria and peptidoglycan remodeling","description":"The top GO terms point to defense responses to Gram-positive bacteria, detection of bacteria, and upregulation of antibacterial peptide biosynthesis, coupled with cell wall processes and peptidoglycan turnover/catabolic activity. This suggests a cohesive theme of host innate immunity targeting Gram-positive pathogens, including remodeling of peptidoglycan components as part of the defense response (with a minor related lipid remodeling term present). ","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0036151","count":2},{"id":"GO:0044117","count":1},{"id":"GO:0071555","count":1},{"id":"GO:0032827","count":1}]},{"hash":"1532176144751192317","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006458","count":10},{"id":"GO:0006469","count":10},{"id":"GO:0032781","count":10},{"id":"GO:0051259","count":10},{"id":"GO:0070389","count":10}]},{"hash":"1077725876799356025","title":"Mitochondrial steroidogenesis and cholesterol transport","description":"Most terms tie mitochondria (cristae formation, ATP synthesis, protein complex assembly) with steroid metabolism (progesterone biosynthesis, cholesterol transport, bile acid regulation, glucocorticoid metabolism). The shared theme is mitochondrial energy production fueling steroid biosynthesis and cholesterol handling, with a few developmental terms likely reflecting broader tissue roles.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0035786","count":1},{"id":"GO:0015986","count":1},{"id":"GO:0042407","count":1},{"id":"GO:0006701","count":1}]},{"hash":"1136115680950928536","title":"Post-transcriptional RNA processing and translation control","description":"The cluster shows strong enrichment for regulation of mRNA splicing, stability, and poly(A) tail dynamics, along with multiple steps in translational initiation and preinitiation complex formation, and even IRES-dependent translation, indicating a cohesive post-transcriptional gene expression program focused on RNA processing and translation control.","confidence":"High","size":10,"edges":27,"triangles":45,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0048025","count":7},{"id":"GO:0060211","count":6},{"id":"GO:0006446","count":6},{"id":"GO:1901407","count":6}]},{"hash":"505657441240942829","title":"Embryonic development and organ morphogenesis","description":"The GO terms cluster around embryonic development and organ morphogenesis across multiple tissues (digit, CNS, mesoderm, renal, heart), suggesting a general developmental program rather than a single tissue-specific function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042733","count":2},{"id":"GO:0007417","count":2},{"id":"GO:0072001","count":2},{"id":"GO:0001707","count":2},{"id":"GO:0046825","count":2}]},{"hash":"393307183213878431","title":"Calcium-regulated cardiac signaling and vesicle dynamics","description":"The GO terms converge on calcium-dependent signaling that controls cardiac muscle function (calcineurin-NFAT, calcium release regulation, phosphorylation), plus broader calcium-modulating pathways and vascular morphogenesis. The inclusion of synaptic vesicle exocytosis/endocytosis regulation suggests coordinated calcium- and phosphorylation-driven vesicle trafficking. Together, these indicate a theme of calcium-driven signaling impacting cardiac physiology and vesicle dynamics.","confidence":"Medium","size":10,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":3},{"id":"GO:0010800","count":3},{"id":"GO:1903244","count":3},{"id":"GO:0007223","count":3},{"id":"GO:0001569","count":3}]},{"hash":"1208247096648460750","title":"MiRNA silencing and post-translational modification","description":"The cluster includes clear signals for RNA-based regulation (positive regulation of miRNA-mediated gene silencing and miRNA-mediated gene silencing by inhibition of translation) alongside protein-processing activities (actin ubiquitination and peptide amidation; including obsolete amidation). While there are outliers related to immune signaling and antiviral responses, the most coherent pattern centers on miRNA-mediated gene regulation and post-translational modification, suggesting a dual theme of RNA-level control and protein maturation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":3},{"id":"GO:0015701","count":2},{"id":"GO:1903886","count":2},{"id":"GO:2000637","count":2},{"id":"GO:1902187","count":2}]},{"hash":"898829779006969850","title":"Unknown","description":"The terms span brain development, immune/cytokine regulation, B cell apoptosis, transcription and ribosome export, intracellular transport, synaptic plasticity, myoblast fusion, and membrane repair, with no single cohesive function tying the cluster together. There are no edges connecting proteins, suggesting a lack of a unified functional module. Therefore, no clear common theme can be inferred.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:1900017","count":3},{"id":"GO:0001783","count":3},{"id":"GO:0045943","count":2},{"id":"GO:0010796","count":2}]},{"hash":"600421694817165614","title":"Neural synaptic plasticity and mRNA processing","description":"The top GO terms cluster around neural functions: learning, glutamatergic synaptic transmission, and positive regulation of synaptic plasticity, pointing to neuronal signaling and plasticity. Additionally, mRNA processing, alternative splicing regulation, and formation of translation preinitiation complexes suggest neuron-specific gene expression control and local protein synthesis, which are key for synaptic changes. Some terms (mechanical stimulus, hypoxia) may reflect broader cellular stress contexts but do not override the central neural theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":2},{"id":"GO:0007612","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0006397","count":2}]},{"hash":"485654003670785992","title":"Golgi-to-ER Vesicle Transport","description":"Top GO terms cluster around retrograde and intra-Golgi vesicle transport (Golgi to ER, endosome-to-Golgi, ER-to-Golgi), Golgi ribbon formation, and vesicle fusion with the Golgi, indicating a cohesive role in Golgi-ER trafficking and Golgi network maintenance.","confidence":"High","size":10,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0048280","count":2},{"id":"GO:0090161","count":2},{"id":"GO:0006891","count":2},{"id":"GO:0042147","count":2}]},{"hash":"1548974746795742720","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by translation (cytoplasmic translation) and ribosome biogenesis/assembly (large and small subunits), indicating proteins tied to ribosome production and protein synthesis. A few outlier terms (eye-antennal disc morphogenesis, ecdysone response, hormone-mediated apoptotic signaling) may reflect broader regulatory connections or incidental annotations, but the core signal clearly points to ribosome assembly and translation.","confidence":"High","size":10,"edges":32,"triangles":40,"max_degree":8,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0042273","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1950070631346243512","title":"Nucleolar transcription and ribosome biogenesis","description":"The top terms point to transcription activities in the nucleolus (rRNA transcription by RNA Pol I, tRNA transcription by RNA Pol III, RNA-templated transcription) and ribosome biogenesis, along with nucleologenesis and chromatin regulation by ncRNA. Together these indicate a coherent theme of nucleolar transcription driving ribosome assembly and related RNA processes.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000448","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0031048","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0042790","count":1}]},{"hash":"1378113526460896435","title":"Neural development and axon guidance","description":"Cluster is dominated by GO terms tied to neural development and connectivity, including long-term neuronal synaptic plasticity, axon fasciculation, and photoreceptor differentiation, along with MAPK signaling regulation and cell adhesion/migration. While some terms relate to broader developmental processes (interleukin-27 signaling, axial mesoderm formation, salivary gland boundary specification), the strongest signals center on neuronal development and axon pathfinding, suggesting a cohesive theme of neural wiring and signaling. This supports labeling the cluster as Neural development and axon guidance.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0048170","count":7},{"id":"GO:0043408","count":7},{"id":"GO:1904237","count":7},{"id":"GO:0070106","count":7},{"id":"GO:0048320","count":7}]},{"hash":"1890985832312489873","title":"Fertilization: sperm\u2013zona pellucida interaction","description":"The cluster\u2019s top GO terms are dominated by fertilization-related processes: binding of sperm to zona pellucida, penetration of zona pellucida, and regulation of acrosome reaction, pointing to a theme of sperm-egg recognition and acrosome activity. Some terms about mammary gland development and lactose biosynthesis are present but appear as peripheral connections; overall the functional signal centers on fertilization-related events.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":5},{"id":"GO:0030879","count":4},{"id":"GO:0007341","count":4},{"id":"GO:0060055","count":3},{"id":"GO:0005989","count":3}]},{"hash":"1824227796390764378","title":"Neurodevelopment and Craniofacial Morphogenesis","description":"The set of GO terms mainly points to developmental processes in the nervous system (neuron differentiation in various regions) and craniofacial structures (palate, cochlea, cartilage, epithelial maturation). A few terms touch other organ systems (neurohypophysis, ureteric bud) but the unifying theme is embryonic development across neural and craniofacial tissues, with some membrane biosynthesis involvement. Confidence in this label is Medium.","confidence":"","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021526","count":10},{"id":"GO:0002070","count":10},{"id":"GO:0030917","count":10},{"id":"GO:0021985","count":10},{"id":"GO:0051216","count":10}]},{"hash":"1942518617816095050","title":"Adhesion-Driven Cell Migration and Rac Signaling","description":"The Top Terms cluster strongly centers on cell adhesion, migration, lamellipodium assembly, and regulation of Rac signaling, indicating proteins involved in adhesion-dependent cytoskeletal remodeling and movement. Immune-related terms (IL-7 response, NK T cell differentiation) and insulin signaling are present but appear ancillary to the core theme of adhesion and motility.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:1904643","count":2},{"id":"GO:1902168","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0030032","count":2}]},{"hash":"1329038243733881701","title":"Golgi-ER vesicle trafficking and SNARE assembly","description":"The top GO terms cluster around vesicle transport between the ER and Golgi, intra-Golgi trafficking, Golgi-to-vacuole transport, and SNARE complex assembly/docking, indicating a cohesive function in Golgi-ER vesicle trafficking and SNARE-mediated membrane fusion. Some neuronal secretion terms are present but likely reflect shared SNARE machinery rather than a distinct neuronal role.","confidence":"High","size":10,"edges":12,"triangles":4,"max_degree":5,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048280","count":6},{"id":"GO:0006891","count":6},{"id":"GO:0006888","count":6},{"id":"GO:0090161","count":6},{"id":"GO:0006896","count":6}]},{"hash":"1433196060128464717","title":"Axon Guidance & Neural Crest Migration","description":"The top GO terms cluster around neural development, including neural crest cell migration, axon extension and fasciculation, and projections of sympathetic and trigeminal neurons, as well as semaphorin-plexin signaling for axon guidance, indicating a cohesive theme of neuronal pathfinding and migration during development; the lectin pathway term appears incidental.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002042","count":2},{"id":"GO:0021785","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0036486","count":2}]},{"hash":"2064684847473898807","title":"Complement activation and inflammatory signaling","description":"This cluster is dominated by complement pathway terms (classical and alternative activation) and membrane attack complex regulation, with supportive immune signaling (IL-4 production, ERK cascade) and angiogenesis/development terms, suggesting a theme of complement-driven inflammatory and vascular signaling, potentially in development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0001701","count":2},{"id":"GO:0001970","count":2},{"id":"GO:0006957","count":2},{"id":"GO:0045766","count":2}]},{"hash":"1633611802904660997","title":"Circadian Sleep Regulation and Cholinergic Signaling","description":"The top terms cluster around rhythmic processes, sleep, and circadian sleep/wake regulation, together with regulation of cholinergic synaptic transmission and acetylcholine-gated channels, suggesting a shared role in circadian control of sleep and cholinergic signaling in the nervous system. A few ancillary terms (endosome/lysosome localization, cuticle biosynthesis, tube diameter) appear as secondary cellular processes but do not redefine the main theme.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903049","count":2},{"id":"GO:0048511","count":2},{"id":"GO:0035158","count":2},{"id":"GO:0032222","count":2},{"id":"GO:0030431","count":2}]},{"hash":"1592624766172255703","title":"Nucleotide metabolism and RNA editing","description":"The top GO terms cluster around nucleotide metabolism (uridine, cytidine, UMP salvage, deoxycytidine, guanine catabolism) and RNA processing/editing (tRNA wobble A-to-I editing), suggesting a cohesive theme of nucleotide biosynthesis/catabolism and RNA modification. Some broader annotations (antibiotic response, xenobiotic degradation) appear, but do not drive the core function of the cluster.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0046109","count":3},{"id":"GO:0019858","count":3},{"id":"GO:0009972","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0002100","count":3}]},{"hash":"1243128030064973197","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000186","count":8},{"id":"GO:0070671","count":8},{"id":"GO:0070935","count":8},{"id":"GO:0097194","count":7},{"id":"GO:0010954","count":7}]},{"hash":"916606160843463197","title":"Plant lipid and phenylpropanoid metabolism","description":"The GO terms center on lipid metabolism (fatty acid biosynthesis; long-chain fatty acid metabolism) and a secondary metabolism pathway (phenylpropanoid metabolism), with an indication of plant biology through the seed germination regulation term. While some terms are broad, the recurring lipid/phenylpropanoid theme plus a plant-specific process supports a plant lipid/secondary metabolism cluster.","confidence":"Medium","size":10,"edges":17,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":1},{"id":"GO:0010030","count":1},{"id":"GO:0019654","count":1},{"id":"GO:0090410","count":1},{"id":"GO:0043041","count":1}]},{"hash":"502182788087349041","title":"Mitochondrial translation and telomere maintenance","description":"These proteins prominently show mitochondrial tRNA aminoacylation and translation terms, alongside telomere maintenance and DNA replication/cell-cycle signals. The mix suggests a cluster where mitochondrial protein synthesis interfaces with genome maintenance pathways, rather than a single strict pathway. Therefore the label captures both the mitochondrial translation core and the accompanying telomere-related annotations.","confidence":"Medium","size":10,"edges":18,"triangles":13,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006430","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0070200","count":5},{"id":"GO:0070154","count":5},{"id":"GO:0070145","count":5}]},{"hash":"1686305487518402819","title":"Viral integration, latency, and retrotransposition","description":"The top terms cluster around DNA processing and viral life-cycle steps\u2014DNA recombination, replication, DNA integration, retrotransposition, viral entry into host cells, and proviral latency\u2014indicating a theme of viral genome handling and integration into host DNA, with related transposition activity. This makes a label focused on viral integration/latency most representative, with supporting DNA metabolism terms.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0008033","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0015074","count":2}]},{"hash":"1084857655172569791","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0006458","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0032781","count":2}]},{"hash":"834480776623594693","title":"Cell motility and vesicle signaling","description":"These terms cluster around cell movement and signaling: lamellipodium assembly, cell migration, and synaptic vesicle exocytosis point to cytoskeletal dynamics and vesicle trafficking; polarity maintenance and PI3K signaling reinforce directional motility. Although a few terms are less related (apoptosis, triglyceride storage), the dominant theme is motility-associated processes with vesicle signaling.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016079","count":2},{"id":"GO:0097194","count":1},{"id":"GO:0016477","count":1},{"id":"GO:0030032","count":1},{"id":"GO:0010890","count":1}]},{"hash":"980060155906925694","title":"Epithelial morphogenesis and junction signaling","description":"This cluster is dominated by terms related to tissue architecture and signaling in epithelial contexts: placental branching morphogenesis, glomerular basement membrane development, smooth septate junction assembly, and regulation of integrin-mediated signaling. These point to processes governing epithelial cell adhesion, basement membrane formation, and cell\u2013cell junctions, suggesting a cohesive theme of tissue morphogenesis and barrier formation. While a few terms touch on immune complement activation or neural synaptic regulation, they appear secondary to the central epithelial development/signaling theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":2},{"id":"GO:2000312","count":2},{"id":"GO:0048168","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0060672","count":2}]},{"hash":"552617407531961737","title":"Multi-tissue embryonic morphogenesis","description":"The top GO terms cluster around developmental morphogenesis across various tissues (heart, eye, limb, placenta, gonads, brain), indicating a shared involvement in embryonic organ formation rather than a single tissue-specific function.","confidence":"High","size":9,"edges":13,"triangles":6,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060527","count":6},{"id":"GO:2000288","count":6},{"id":"GO:0003148","count":6},{"id":"GO:0048048","count":6},{"id":"GO:0007507","count":6}]},{"hash":"452547166516935110","title":"Cell division and cytoskeletal dynamics","description":"This cluster is anchored by GO terms related to cell cycle, cytokinesis, microtubule nucleation, and protein polymerization, pointing to coordinated control of division and cytoskeletal organization. While a couple of terms reference neuron differentiation and immune signaling, they are only single occurrences, so the dominant theme remains cell division and cytoskeletal dynamics.","confidence":"High","size":9,"edges":19,"triangles":19,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":1},{"id":"GO:1905792","count":1},{"id":"GO:0007020","count":1},{"id":"GO:2000767","count":1},{"id":"GO:0030182","count":1}]},{"hash":"1301240720268880795","title":"Unknown","description":"Top GO terms are from neural development, plant morphogenesis, epithelial development, metabolism, and mRNA localization, spanning diverse species and tissues with no single coherent function. Because the terms do not converge on a shared biological process, there isn't a clear, specific label that accurately represents the cluster.","confidence":"","size":9,"edges":31,"triangles":53,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0021937","count":5},{"id":"GO:0048482","count":5},{"id":"GO:0021526","count":5},{"id":"GO:0008045","count":5},{"id":"GO:0030032","count":5}]},{"hash":"1056307314667833519","title":"Endothelial barrier and coagulation regulation","description":"The strongest signals cluster around endothelial barrier establishment, positive regulation of blood coagulation, and calcium-dependent cell-cell adhesion, with proteolysis and LDL signaling aligning with vascular signaling/remodeling; while transcriptional repression and a defense term appear, they are less central to the vascular/coagulation theme.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0050830","count":2},{"id":"GO:0044130","count":2},{"id":"GO:1903142","count":2},{"id":"GO:0030194","count":2}]},{"hash":"549086577786287717","title":"RNA processing and transcription machinery","description":"The top GO terms cluster around RNA maturation and processing (tRNA processing, spliceosomal assembly, mRNA splicing via spliceosome, mRNA processing, maturation of SSU-rRNA, histone mRNA metabolism) and transcription termination (RNA polymerase II). This points to proteins involved in RNA processing and transcription regulation. A couple of stress-response terms (water deprivation, abscisic acid) may reflect broader regulatory connections or annotation noise, but do not alter the main RNA-centric theme.","confidence":"High","size":9,"edges":33,"triangles":66,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":3},{"id":"GO:0000245","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0030490","count":2}]},{"hash":"955720539084942054","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":26,"triangles":32,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0042766","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0006366","count":3}]},{"hash":"1035723237716499763","title":"Unknown","description":"The top GO terms span multiple, disparate systems (kidney development; bone remodeling; GABAergic synaptic transmission; pH and zinc response; CO2 transport; fluid shear stress), with no single cohesive function uniting the cluster. Therefore a precise, representative label is not justifiable. ","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0045672","count":4},{"id":"GO:0032230","count":4},{"id":"GO:0009268","count":4},{"id":"GO:0010043","count":4}]},{"hash":"2017406880249140343","title":"Embryonic organogenesis and placental morphogenesis","description":"These GO terms cluster around embryonic development and organ formation (palate and endocrine system development, heart EMT in endocardial cushion formation, left-right patterning, placental and cartilage morphogenesis, pancreatic cell development), with a minor spliceosome term as a potential outlier.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060707","count":5}]},{"hash":"1750065583449828228","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015012","count":1},{"id":"GO:0030205","count":1},{"id":"GO:0006711","count":1},{"id":"GO:0030210","count":1},{"id":"GO:0050427","count":1}]},{"hash":"169463530099572816","title":"Neural development and glycinergic/monoaminergic signaling","description":"This cluster features GO terms tied to neural development (adenohypophysis and thalamus development, glial growth) alongside neurotransmission processes (glycinergic synaptic transmission, dopamine uptake/ catabolism, serotonin secretion). The shared theme appears to be proteins involved in developing neural circuits and regulating both glycinergic and monoaminergic signaling.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021984","count":2},{"id":"GO:0042066","count":2},{"id":"GO:0021794","count":2},{"id":"GO:0051583","count":2},{"id":"GO:1903346","count":2}]},{"hash":"1722639976246830976","title":"Unknown","description":"The GO terms span immune cell migration, T cell differentiation, neural stem cell maintenance, endothelial proliferation, glycosylation processes, and even DNA transposition/integration, with no single cohesive biological theme linking all proteins. The scattered functional signals suggest there isn\u2019t a clear, common function for this cluster beyond miscellaneous cellular processes.","confidence":"","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0036071","count":1},{"id":"GO:0002522","count":1},{"id":"GO:0042355","count":1},{"id":"GO:0021799","count":1},{"id":"GO:0006486","count":1}]},{"hash":"1529797425304155057","title":"Insect neuropeptide signaling and larval behavior","description":"The top GO terms emphasize neuropeptide signaling, neuromuscular transmission, and larval locomotory behavior, together with behavioral regulation (e.g., egg-laying, mating) and molting-related cuticle processes. This points to a cohesive theme of neuroendocrine control of insect larval development and behavior, rather than disparate processes. ","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0010459","count":1},{"id":"GO:1901045","count":1},{"id":"GO:0002209","count":1},{"id":"GO:0007218","count":1}]},{"hash":"1015039141572742641","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning dormancy in symbionts, stress response, immune differentiation, cell migration, kinase regulation, calcium transport, pinocytosis, insulin-related glucose import, cardiac depolarization, and telomere localization. There is no single shared function or pathway linking these terms, and the cluster shows no connectivity, so a coherent label cannot be assigned. ","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2},{"id":"GO:0002268","count":1},{"id":"GO:0016477","count":1},{"id":"GO:0071901","count":1}]},{"hash":"1240973504989666408","title":"Axonal Domain Organization and Myelination","description":"The enriched GO terms point to neural development and axonal organization\u2014paranode/juxtaparanode protein localization, CNS development, myelination, and synapse assembly\u2014titting the idea of a module of neural development and myelin-related proteins. A few terms are non-neural, but the dominant signal is neuronal maturation and axon-domain organization.","confidence":"High","size":9,"edges":30,"triangles":51,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007432","count":7},{"id":"GO:0007156","count":7},{"id":"GO:0001822","count":7},{"id":"GO:0071206","count":7},{"id":"GO:0002175","count":7}]},{"hash":"2030874503797040985","title":"Transmembrane Transporters for Sugars and Metabolites","description":"The top GO terms cluster around transmembrane transport of various substrates (sialic acid, galactose, arabinose, fucose, nitrates, vitamins) and related metabolite handling, including neurotransmitter loading into vesicles. This suggests the proteins function as membrane transporters or components of vesicular transport systems, collectively mediating intake and distribution of sugars and other nutrients/metabolites. ","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":1},{"id":"GO:0015706","count":1},{"id":"GO:0042891","count":1},{"id":"GO:0098700","count":1},{"id":"GO:0035461","count":1}]},{"hash":"2106780194296316934","title":"Nervous system development and myelination","description":"Most of the top GO terms point to neural development and axon-associated processes: CNS development, myelination, protein localization to paranode/juxtaparanode regions, and positive regulation of synapse assembly. While a few terms relate to non-neural tissues (salivary gland/kidney) or neutrophil clearance, the dominant theme is nervous system development and myelination, suggesting this cluster represents neuronal maturation and myelin-related organization.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007432","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0071206","count":3},{"id":"GO:0002175","count":3}]},{"hash":"1911998171903626663","title":"Neural development and synapse formation","description":"This cluster is dominated by terms tied to central nervous system development and synaptic organization, including NMDA receptor clustering, receptor localization to synapse, ventral spinal cord development, and midbrain-hindbrain boundary formation, with polarity specification of dorsal/ventral axis and integrin activation contributing to cell adhesion during neural development. A few terms (immunoglobulin production, insulin response) appear ancillary or noisy, but do not override the main neural/synaptic theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002642","count":1},{"id":"GO:0033622","count":1},{"id":"GO:0032367","count":1},{"id":"GO:0007311","count":1},{"id":"GO:2001274","count":1}]},{"hash":"1619654363741679938","title":"Auditory neural signaling","description":"The terms cluster around neural transmission and synaptic activity related to hearing: nerve impulse transmission, glycinergic synaptic transmission, membrane depolarization, sensory perception of sound, and vestibulocochlear nerve development, with supportive links to dopamine secretion. A couple of outliers (adaptive immune response, ovulation rhythm) appear unrelated, but the dominant theme is auditory neural signaling.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051971","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0007605","count":1},{"id":"GO:0060112","count":1},{"id":"GO:0060012","count":1}]},{"hash":"1395655790700651622","title":"Mitochondrial membrane lipid biosynthesis and remodeling","description":"The top GO terms are dominated by lipid metabolism and remodeling\u2014phosphatidylcholine, cardiolipin, ether lipids, and triglycerides\u2014along with platelet activating factor biosynthesis and mitochondrial ATP synthesis, pointing to coordinated membrane lipid biosynthesis/remodeling with a mitochondrial focus. ","confidence":"High","size":9,"edges":20,"triangles":19,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0002071","count":4},{"id":"GO:0016024","count":4},{"id":"GO:0019432","count":4},{"id":"GO:0006663","count":4},{"id":"GO:0008611","count":4}]},{"hash":"775706100707453821","title":"Steroid and lipid biosynthesis","description":"These proteins are dominated by GO terms centered on the biosynthesis of lipids and steroid-derived compounds, including sphingolipids, fatty acids, retinoic acid, estrogens, and glucocorticoids. The cluster also touches on related pigment biosynthesis (melanin) and other lipid-signaling molecules, pointing to a cohesive role in the production of lipid- and steroid-based metabolites. A redox term appears peripherally but does not override the core biosynthetic theme.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030148","count":9},{"id":"GO:0006703","count":9},{"id":"GO:0006710","count":9},{"id":"GO:0042438","count":9},{"id":"GO:0006666","count":9}]},{"hash":"1585412286745028347","title":"ECM remodeling and tissue morphogenesis","description":"The GO terms point to extracellular matrix remodeling (basement membrane disassembly, collagen catabolic process) and skeletal/organ development (bone resorption, intramembranous ossification, epithelial tube branching in lung morphogenesis). Additional regulatory/catabolic terms (regulation of catalytic activity, neuropeptide catabolic process, thyroid hormone response) support a broader remodeling and developmental theme rather than a single isolated function. Confidence: Medium","confidence":"","size":9,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050790","count":1},{"id":"GO:0097067","count":1},{"id":"GO:0034769","count":1},{"id":"GO:0051603","count":1},{"id":"GO:0060441","count":1}]},{"hash":"1081114003493730620","title":"N-glycan trimming and ERAD pathway","description":"The top terms cluster around N-linked glycosylation and mannose trimming steps in the ER and Golgi, including ubiquitin-dependent ERAD and retrograde transport from ER to cytosol, which together point to glycoprotein maturation and quality control processes. The presence of trimming on multiple mannose branches and Golgi trimming reinforces a cohesive theme of N-linked glycan processing, with a peripheral note of immunoglobulin production in mucosa. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:1904382","count":1},{"id":"GO:0036509","count":1},{"id":"GO:0036511","count":1},{"id":"GO:0036510","count":1}]},{"hash":"1606085540448370004","title":"Cytoskeleton dynamics and cell cycle regulation","description":"The top terms cluster around spindle assembly, actin filament bundle assembly, and cell migration, pointing to cytoskeletal organization and cellular movement. Additional terms such as negative regulation of serine/threonine kinase activity and telomere maintenance tie into cell division and signaling control, suggesting a broader theme of division-related regulation. Some terms (vitamin D response, follicular dendritic cell differentiation) appear more peripheral noise. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":4},{"id":"GO:0051225","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0033280","count":4},{"id":"GO:0016567","count":4}]},{"hash":"2044477949583800506","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050873","count":1},{"id":"GO:0040015","count":1},{"id":"GO:0048235","count":1},{"id":"GO:0006189","count":1}]},{"hash":"1964399296480426434","title":"Retinoic acid signaling and reproductive tissue development","description":"The top GO terms center on retinoic acid signaling and cellular responses to RA, with transcriptional regulation, plus developmental processes relevant to male gonad and prostate gland development, and related growth pathways such as JNK and TGF-beta. This suggests a coherent theme of RA-mediated developmental signaling in reproductive tissues, with ancillary links to broader growth and immune-related processes.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048384","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0060528","count":2},{"id":"GO:0006351","count":2},{"id":"GO:1904179","count":2}]},{"hash":"562480512943233915","title":"Unknown","description":"The terms cover a broad mix of development, reproduction, molting, and sensory responses in nematodes, with no single shared function tying the nine proteins together. Therefore Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043050","count":1},{"id":"GO:0006508","count":1},{"id":"GO:2000360","count":1},{"id":"GO:0060468","count":1},{"id":"GO:0007313","count":1}]},{"hash":"298931614489654685","title":"SNARE-Mediated Synaptic Exocytosis and Golgi Trafficking","description":"This cluster centers on synaptic vesicle trafficking and exocytosis, with GO terms for SNARE complex assembly, vesicle docking, neurotransmitter release, and insertion of receptors, plus intra-Golgi and ER-Golgi transport\u2014together pointing to a core synaptic neurotransmission and Golgi trafficking program.","confidence":"High","size":8,"edges":9,"triangles":0,"max_degree":3,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0060291","count":4},{"id":"GO:0001916","count":3},{"id":"GO:0061669","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0035493","count":3}]},{"hash":"1825279306350149117","title":"Neuronal spine morphogenesis and Rac signaling","description":"Interpretation: The top GO terms cluster around neuronal development and actin-cytoskeleton remodeling, including positive/negative regulation of dendritic spine morphogenesis, Rac signaling, and lamellipodium assembly, with hippocampus development supporting a brain-specific context. While a few terms are less directly connected (e.g., mitotic spindle assembly), the dominant theme points to proteins that regulate spine formation and cytoskeletal dynamics in neurons.","confidence":"High","size":8,"edges":12,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0032966","count":3},{"id":"GO:0051291","count":3},{"id":"GO:0000186","count":3},{"id":"GO:0021766","count":3}]},{"hash":"400773684667138794","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":9,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0097171","count":2},{"id":"GO:0031247","count":1},{"id":"GO:0019373","count":1},{"id":"GO:0006045","count":1},{"id":"GO:0046295","count":1}]},{"hash":"2002550193784379326","title":"Smooth muscle differentiation and relaxation","description":"The GO terms cluster around smooth muscle development (enteric and cardiac vascular smooth muscle differentiation), muscle relaxation, and neurotransmitter signaling (acetylcholine metabolism and GPCR pathways), suggesting a cohesive theme of smooth/cardiac muscle regulation and development with related neural signaling.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060408","count":4},{"id":"GO:0071380","count":4},{"id":"GO:0045745","count":4},{"id":"GO:0019835","count":4},{"id":"GO:2000724","count":4}]},{"hash":"2027031396750050299","title":"GPCR-Mediated Signaling and Cardiovascular Regulation","description":"This cluster centers on GO terms involving G protein-coupled receptor (GPCR) signaling and its regulation, including dopamine receptor signaling, acetylcholine metabolism, renin-angiotensin\u2013related blood pressure control, and prostaglandin response, all of which tie into cardiovascular and neural signaling. Some terms (midgut development, cytolysis, immune modulation) are less directly linked, but the dominant pattern is GPCR signaling and its cardiovascular implications, justifying this label as a specific, representative theme for the cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":8},{"id":"GO:0007195","count":8},{"id":"GO:0060408","count":8},{"id":"GO:0007497","count":8},{"id":"GO:0006955","count":8}]},{"hash":"35764134055173450","title":"Ribosome biogenesis and translation initiation","description":"This cluster is dominated by GO terms related to ribosome assembly (ribosomal large subunit biogenesis, maturation of LSU rRNA) and translation-related events (formation of translation preinitiation complex, translation reinitiation), indicating proteins primarily involved in the protein synthesis machinery. A few ancillary terms reflect broader cellular responses but do not define the main function of the group.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:1905705","count":2},{"id":"GO:0010659","count":2}]},{"hash":"1253206002825474388","title":"Spliceosome and nucleosome assembly factors","description":"Although the set includes diverse roles, the strongest recurring signals are terms for assembly of RNA-protein complexes (spliceosomal complex assembly, tri-snRNP complex assembly) and nucleosome assembly, suggesting involvement in macromolecular complex assembly, particularly RNA splicing and chromatin packaging. A few other GO terms (development, signaling, cell surface localization) appear less central, likely reflecting multifunctionality or annotation noise, but the core theme remains assembly-related.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072553","count":1},{"id":"GO:0000245","count":1},{"id":"GO:0006334","count":1},{"id":"GO:1903586","count":1},{"id":"GO:0048872","count":1}]},{"hash":"1667299014561916409","title":"Cardiac sarcomere organization and contraction","description":"Most enriched terms point to heart muscle structure and function: sarcomere organization, cardiac muscle contraction, and regulation of heart rate by epinephrine. Negative regulation of vascular smooth muscle cell proliferation/migration also fits cardiovascular regulation, supporting a cardiac/sarcomeric theme. A couple terms appear unrelated (spicule insertion) or obsolete, but the core signal is cardiac muscle function, justifying the label.","confidence":"High","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060298","count":4},{"id":"GO:1904706","count":4},{"id":"GO:0034609","count":4},{"id":"GO:1904753","count":4},{"id":"GO:0045214","count":4}]},{"hash":"2259348603626490314","title":"Immune signaling and cell migration","description":"This cluster is driven by immune-related GO terms (follicular dendritic cell differentiation; regulation of T cell receptor signaling) along with GPCR signaling and calcium import, plus cell migration and endocytic processes, suggesting a cohesive theme of immune cell signaling and trafficking. Some outlier terms exist, but the dominant pattern points to immune signaling pathways and migratory behavior.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002268","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0032342","count":2},{"id":"GO:1903244","count":2},{"id":"GO:0008627","count":2}]},{"hash":"1076766252587923997","title":"Glycinergic and monoaminergic neural signaling","description":"The GO terms point to synaptic transmission involving glycine (glycinergic) as well as monoamines like dopamine and serotonin, suggesting a cluster centered on neurotransmission in neurons. Although a few development-related terms appear, the prominent pattern is glycinergic and monoaminergic signaling within the neural context.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021984","count":3},{"id":"GO:0042066","count":3},{"id":"GO:0021794","count":3},{"id":"GO:0051583","count":3},{"id":"GO:1903346","count":3}]},{"hash":"1306785450249682175","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0071902","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007275","count":3}]},{"hash":"1637763693665358711","title":"Integrin-mediated leukocyte adhesion and migration","description":"The top GO terms cluster around integrin-dependent adhesion and signaling (heterotypic adhesion, integrin-mediated adhesion, cell-substrate junctions), along with substrate-dependent migration and extravasation, plus immune cell\u2013related processes (neutrophil chemotaxis, T cell activation). This combination suggests proteins that coordinate integrin signaling to promote leukocyte adhesion to endothelial/extracellular matrices and subsequent migration into tissues, i.e., immune cell trafficking.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034113","count":2},{"id":"GO:0045123","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0006929","count":2},{"id":"GO:0002291","count":2}]},{"hash":"594797498756983774","title":"Steroid and lipid biosynthesis","description":"These proteins are associated with biosynthesis of lipids and steroid-related compounds (sphingolipids, fatty acids, estrogen, glucocorticoids, retinoic acid), suggesting a lipid/hormone biosynthesis cluster; melanin and tropane alkaloid terms reflect broader biosynthetic roles.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030148","count":8},{"id":"GO:0006703","count":8},{"id":"GO:0006710","count":8},{"id":"GO:0042438","count":8},{"id":"GO:0006666","count":8}]},{"hash":"2013694097792183836","title":"Neural Development and Axon Guidance","description":"This cluster is dominated by GO terms related to neural development, including sensory neuron axon guidance, branchiomotor neuron axon guidance, facial nerve organization, trigeminal ganglion development, and cerebellar Purkinje cell layer development, plus GnRH neuronal migration. A few terms touch on vascular/immune processes, but the strongest signal is neural patterning and axon pathfinding, indicating the proteins mainly participate in nervous system development rather than immunity.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0060978","count":2},{"id":"GO:0021828","count":2},{"id":"GO:0002042","count":2},{"id":"GO:0097374","count":2}]},{"hash":"1896626070184035814","title":"Ubiquitin-Proteasome System Components","description":"The top GO terms center on ubiquitination (K48, K11), SCF-dependent proteasomal degradation, ER-associated degradation, histone catabolic processes, and transcription-related regulation, indicating a cluster of proteins involved in tagging substrates for proteasomal degradation and related chromatin regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051865","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0036205","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1923874762538422681","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039702","count":2}]},{"hash":"433576856882241318","title":"Neural development and axon guidance signaling","description":"The most represented terms are nervous system development and axon guidance, with ROBO (Roundabout) and Smoothened pathways indicating axon navigation and hedgehog signaling in neural contexts. ERK1/2 cascade regulation supports active signal transduction during development. While some terms like kidney development or T cell signaling are broader, the dominant pattern points to neural wiring and development.","confidence":"High","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0050852","count":4}]},{"hash":"2170426577128454286","title":"Ribosome biogenesis and translation","description":"This cluster is driven by multiple translation- and ribosome-related terms: cytoplasmic translation, ribosome biogenesis, and ribosomal subunit export, with tRNA modification also tying into translation fidelity. Other terms like cell division or hepatocyte apoptosis appear less central, but may reflect growth and stress connections to protein synthesis. Overall, the dominant theme is ribosome function and protein synthesis.","confidence":"High","size":8,"edges":9,"triangles":0,"max_degree":5,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006400","count":3},{"id":"GO:0042832","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0002181","count":3}]},{"hash":"1882683914399279178","title":"Ciliary Assembly and Photoreceptor Trafficking","description":"Top GO terms cluster around cilium assembly, intraflagellar transport, photoreceptor outer segment organization, and localization to ciliary, plasma membrane, and Golgi compartments, with a link to kidney development. This pattern indicates a coherent role in ciliogenesis and targeted trafficking in sensory (retinal) and renal cells, especially photoreceptor cells, where ciliary transport to the outer segment is essential.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060828","count":1},{"id":"GO:0061512","count":1},{"id":"GO:0035845","count":1},{"id":"GO:0060271","count":1},{"id":"GO:0090002","count":1}]},{"hash":"1786579807671158159","title":"Viral assembly and host cell stress response","description":"The cluster includes GO terms for viral processes (viral release from host cell, virion assembly, viral capsid assembly) indicating involvement in the viral life cycle, along with host-response and protein-folding-related terms (response to unfolded protein, chaperone-mediated assembly, protein import into mitochondrial intermembrane space, chaperone/refolding). This combination suggests proteins tied to viral assembly and concurrent host cell stress responses, including chaperone activity and organelle import during infection.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0051131","count":1},{"id":"GO:0045041","count":1},{"id":"GO:0006986","count":1}]},{"hash":"404429444396901318","title":"Viral replication and host immune evasion","description":"The top GO terms point to viral life cycle steps (viral RNA genome replication, viral protein processing) and host defense modulation (symbiont-mediated suppression of IRF3 signaling, perturbation of host ubiquitin-like protein modification), indicating a theme of virus-host interaction and immune evasion. A few terms about vitamin D response or keratinocyte differentiation seem peripheral to this core viral-centric pattern, suggesting incidental associations rather than central function. Overall, the cluster likely represents viral infection processes and host immune modulation.","confidence":"High","size":8,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0039648","count":1},{"id":"GO:0019082","count":1},{"id":"GO:0033128","count":1},{"id":"GO:1901837","count":1}]},{"hash":"1834909045529644070","title":"Retroviral DNA integration and latency","description":"The top GO terms point to viral infection and retroviral life-cycle steps, including entry into the host nucleus, reverse transcription (RNA-templated DNA biosynthesis), DNA integration into the host genome, DNA recombination, and establishment of proviral latency, with supporting notes on replication and host apoptotic interactions. This cohesive theme suggests a cluster centered on retroviral genome integration and latency processes. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903704","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1433200310802778598","title":"Cell wall polysaccharide biosynthesis and glycosylation","description":"The cluster\u2019s top GO terms cluster around cell wall construction and carbohydrate processing, including cell wall organization, teichoic acid biosynthesis, cellulose biosynthesis, various forms of protein O-linked glycosylation, and UDP-glucose metabolism. This points to a shared function in building and decorating cell wall polysaccharides, with glycosylation pathways as a key common thread; a few terms (like immunoglobulin production) may reflect annotation noise but do not override the main theme.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0018243","count":2},{"id":"GO:0030213","count":2},{"id":"GO:0002378","count":2},{"id":"GO:0019350","count":2}]},{"hash":"1997678520068118917","title":"Developmental cell adhesion and migration","description":"These terms collectively emphasize adhesion, migration, and guidance processes central to development. Evidence includes integrin-mediated adhesion and substrate-dependent spreading, sprouting angiogenesis\u2013related cell migration, axon extension and synapse assembly, and Drosophila-specific developmental contexts like follicle cell stalk formation and tracheal growth.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002042","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0045987","count":1},{"id":"GO:0030713","count":1}]},{"hash":"1630827909702695542","title":"Inflammatory Cytokine Signaling","description":"The top GO terms cluster around NF-kappaB activation and responses to interleukins (IL-1, IL-6, IL-8) and production of inflammatory mediators, which together point to immune/inflammatory signaling as the core function of this cluster. While carbohydrate catabolic and chitin-related terms appear, they are less cohesive with the primary inflammatory theme, suggesting additional, secondary associations.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0007250","count":4},{"id":"GO:0071347","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0070741","count":3},{"id":"GO:0072606","count":3}]},{"hash":"1411370662684812469","title":"Lipid Biosynthesis and Sterol Metabolism","description":"The top GO terms are dominated by lipid-related processes, notably cholesterol esterification, monounsaturated fatty acid biosynthesis, and sphingolipid metabolism (MIPC), suggesting a core theme of lipid biosynthesis and sterol processing. Other terms like tarsal gland development or nitric oxide biosynthesis appear as peripheral annotations, adding some noise but not outweighing the lipid-centric signal. Therefore, the label Lipid Biosynthesis and Sterol Metabolism is a reasonable, though not perfectly exclusive, cluster name.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0034435","count":2},{"id":"GO:1903699","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0006809","count":2}]},{"hash":"1481414559539325580","title":"Steroid and eicosanoid biosynthesis","description":"The cluster is best labeled by lipid-derived hormone production, with multiple GO terms for prostaglandin biosynthesis and biosynthesis of cortisol, aldosterone, and progesterone, plus epoxygenase CYP pathways, indicating steroid/eicosanoid metabolism as the core function; some extra terms (camphor catabolic process, ozone response, tongue muscle differentiation) are likely incidental annotations.","confidence":"Medium","size":8,"edges":8,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":2},{"id":"GO:0019383","count":1},{"id":"GO:2001037","count":1},{"id":"GO:0042904","count":1},{"id":"GO:0032342","count":1}]},{"hash":"1604403961522518179","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":2},{"id":"GO:0046444","count":2},{"id":"GO:0034628","count":2},{"id":"GO:0006747","count":2},{"id":"GO:1990966","count":2}]},{"hash":"1595495281520888901","title":"Glycoprotein glycosylation in development","description":"This cluster combines glycosylation-related terms (arabinogalactan protein metabolism, O-linked glycosylation via hydroxyproline, Lewis a epitope biosynthesis, poly-N-acetyllactosamine biosynthesis) with developmental and cell-surface processes (root hair development, insect visual primordium formation, follicle epithelium polarity, and cell adhesion), suggesting a shared theme where glycan modifications of cell-surface proteins regulate adhesion, polarity, and morphogenesis across species.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0080147","count":1},{"id":"GO:0001744","count":1},{"id":"GO:0048354","count":1},{"id":"GO:0075015","count":1},{"id":"GO:0042248","count":1}]},{"hash":"1601689431369011327","title":"Unknown","description":"The TOP terms cover both glycosylation processes (N-glycan fucosylation, protein glycosylation, Lewis a epitope biosynthesis) and immune/regulatory signals (leukocyte migration, CD4+ regulatory T cell differentiation, calcineurin-NFAT signaling), along with neuronal development terms (neuronal stem cell maintenance, radially oriented cortical cell migration) and metabolism (adenosine biosynthesis). The wide spread of functions with only single-term support suggests no single cohesive theme, so a precise, representative label cannot be confidently assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036071","count":1},{"id":"GO:0002522","count":1},{"id":"GO:0042355","count":1},{"id":"GO:0021799","count":1},{"id":"GO:0006486","count":1}]},{"hash":"1428533096066621694","title":"ER Stress Response and Protein Folding","description":"This cluster is dominated by GO terms for ER-associated protein folding and the unfolded protein response, including ER stress\u2013driven translation initiation, plus redox-related processes (redox homeostasis, hydrogen peroxide response, deglutathionylation). The presence of cytochrome complex assembly hints at broader redox connections. Together, these terms point to ER quality control and redox regulation under stress.","confidence":"High","size":8,"edges":15,"triangles":10,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":5},{"id":"GO:0034975","count":5},{"id":"GO:0070389","count":4},{"id":"GO:0006986","count":4},{"id":"GO:0036494","count":4}]},{"hash":"1522174965588760699","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around developmental processes across tissues and organs\u2014endocrine system development, left-right pattern formation, EMT in heart development, cartilage and pancreatic development, and placental formation\u2014with supportive roles for gene expression regulation (splicing and transcription). This suggests a cohesive theme of embryogenesis and tissue morphogenesis rather than a single biochemical function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0000055","count":3}]},{"hash":"958512915089435508","title":"Metal ion transport and chemical stress response","description":"The cluster\u2019s top terms cluster around metal ion transport (zinc/cadmium) and responses to chemical stimuli (curcumin, catechin), suggesting a cohesive theme of metal ion handling combined with xenobiotic/chemical stress responses, though a few terms (glycoside catabolic process, cell adhesion, host-cell entry regulation) are less related. ","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1904643","count":1},{"id":"GO:1902168","count":1},{"id":"GO:0007155","count":1},{"id":"GO:0046689","count":1},{"id":"GO:0016139","count":1}]},{"hash":"873464379480686737","title":"Unknown","description":"There are no GO terms or connections provided to unify the 8 proteins, and the graph has no edges or triangles, so no common functional theme can be inferred. Therefore, the cluster is labeled Unknown with no confidence.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"361637616946942151","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044205","count":4},{"id":"GO:0006207","count":4},{"id":"GO:0006015","count":3},{"id":"GO:0019557","count":2},{"id":"GO:0043419","count":2}]},{"hash":"603374067056909959","title":"Unknown","description":"The top GO terms span immune signaling (TLR9, LPS response), hormonal responses (estrogen stimulus, ovulation rhythm), and neural/sensory processes (sound perception, vestibulocochlear development, glycinergic transmission, dopamine regulation). There isn\u2019t a single cohesive function tying all terms together, suggesting diverse or mixed roles; thus a concise representative label isn\u2019t determinable.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071391","count":2},{"id":"GO:0034162","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0060112","count":2}]},{"hash":"1306844116906024940","title":"Cell Cycle Signaling and DNA Replication","description":"These proteins show enrichment in mitotic processes (kinetochore-microtubule attachment, intra-S checkpoint signaling), DNA replication, and meiosis checkpoints, alongside signaling pathways linked to stress responses (calcineurin-NFAT, cardiac hypertrophy) and development (blood vessel morphogenesis). While there are outliers related to cocaine response, the core theme centers on cell cycle regulation and signal transduction governing proliferation and genome maintenance.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051531","count":7},{"id":"GO:0046086","count":7},{"id":"GO:0051315","count":7},{"id":"GO:1903244","count":7},{"id":"GO:0031573","count":7}]},{"hash":"1082990082005501001","title":"Translation machinery and regulation","description":"The top GO terms are dominated by translation and ribosome-related processes (translation, cytoplasmic and mitochondrial translation, ribosome disassembly, regulation of translational termination, and translational fidelity). A few terms like glial proliferation or RNA-templated transcription are less representative, but do not override the main theme. Thus the cluster most likely corresponds to the protein synthesis machinery and its regulation.","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0032790","count":1},{"id":"GO:0006449","count":1},{"id":"GO:2000767","count":1},{"id":"GO:0002184","count":1}]},{"hash":"1830967115279175823","title":"Transcription Regulation & Chromatin Dynamics","description":"Top GO terms cluster around DNA-templated transcription, transcription regulation (Pol I), and chromatin-related processes (rDNA heterochromatin, telomere maintenance), suggesting a theme of nuclear gene-expression control and chromatin state.","confidence":"Medium","size":7,"edges":11,"triangles":10,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0031647","count":6},{"id":"GO:0016479","count":5},{"id":"GO:0010882","count":5},{"id":"GO:0032204","count":5}]},{"hash":"2275692133623631955","title":"Protein phosphorylation regulators","description":"The cluster is dominated by GO terms tied to phosphorylation, especially positive regulation of peptidyl-threonine phosphorylation and protein phosphorylation, pointing to a shared role in phosphorylation-mediated signaling. Other terms like ABA signaling and development contexts may reflect broader system-specific roles of these proteins, but phosphorylation-based regulation is the common thread.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010800","count":6},{"id":"GO:0006468","count":6},{"id":"GO:0009738","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0014044","count":6}]},{"hash":"1539906684140570278","title":"Neural growth signaling and cytoskeleton","description":"Top terms in this cluster point to cytoskeletal remodeling and neural development, with multiple terms involving focal adhesion regulation, actin cytoskeleton reorganization, axon extension, and dopamine response. While there are some cell-cycle and immune-related terms present, the dominant theme is neural growth signaling coupled to cytoskeletal dynamics, justifying a label centered on neural development and cytoskeletal regulation.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0051893","count":4},{"id":"GO:0000186","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0043366","count":4}]},{"hash":"2084423945500884351","title":"Transcription Regulation & RNA Processing","description":"This cluster centers on transcription control (DNA-templated transcription; negative regulation of transcription elongation by RNA polymerase II) and RNA metabolism (miRNA processing; maintenance of RNA location), with NF-kappaB signaling linking to transcriptional regulation. Some terms are obsolete or peripheral, but the dominant theme ties to transcription regulation and RNA processing.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061428","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0034244","count":2},{"id":"GO:0009190","count":2},{"id":"GO:0090282","count":2}]},{"hash":"2095866685899417495","title":"Neural vesicle trafficking and exosome regulation","description":"The top GO terms cluster around synaptic vesicle exocytosis, multivesicular body sorting, and exosome secretion, with supporting brain development and actin dynamics terms, suggesting a coherent role in neural vesicle trafficking and exosome biology.","confidence":"High","size":7,"edges":6,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000300","count":4},{"id":"GO:0071985","count":4},{"id":"GO:0045956","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0031384","count":4}]},{"hash":"1985951014982871439","title":"Mitochondrial import and cristae maintenance","description":"The top terms cluster around mitochondria: protein import into the intermembrane space, cristae formation, and mitochondrial calcium ion homeostasis, along with related metabolic processes. While a couple terms touch signaling (NF-kappaB regulation, estrogen response), the core theme is mitochondrial structure and metabolism, so the name reflects the dominant function of the cluster. ","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0045041","count":2},{"id":"GO:0051560","count":2},{"id":"GO:0042407","count":2}]},{"hash":"2259644669005487684","title":"Unknown","description":"The top GO terms include regulation of DNA-templated transcription, membrane potential regulation, pH changes, transport, secretion, and even viral RNA genome replication, which appear scattered across diverse cellular processes. Given there are no edges and no clear functional theme tying these terms together, there isn't a coherent label to assign beyond Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0010796","count":2},{"id":"GO:0031384","count":2},{"id":"GO:0039694","count":2},{"id":"GO:0007399","count":2}]},{"hash":"1154940930982345914","title":"Cardiac muscle contraction and heart development","description":"The cluster is dominated by terms related to cardiac muscle function and electrophysiology, including cardiac muscle contraction, regulation of SA node action potential, sarcomere organization, and clustering of voltage-gated potassium channels, as well as heart development and related muscle structure. Some terms (e.g., bone ossification, Fc-epsilon receptor signaling) appear peripheral and may reflect annotation noise or multi-function proteins, but the core theme clearly aligns with cardiac muscle architecture and function.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0038095","count":2}]},{"hash":"2113179591359719872","title":"Neural and sensory development","description":"This cluster is dominated by GO terms tied to development of neural and sensory tissues (hippocampus development, neuron migration, retinal cone cell development, brain ventricle development), with supporting cellular processes like actin-based vesicle transport. A few terms (membrane repair, sperm binding) are less related, but the main signal is neural/sensory tissue development.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0021766","count":2},{"id":"GO:0001764","count":2},{"id":"GO:1903477","count":2},{"id":"GO:0060474","count":2},{"id":"GO:0046549","count":2}]},{"hash":"926531667042822880","title":"Calcium-Triggered Mitophagy","description":"Top GO terms point to calcium ion transport and regulation of store-operated calcium entry, together with autophagy of mitochondrion. This pattern suggests the cluster centers on mitochondrial calcium handling that links to mitophagy, i.e., calcium-dependent mitochondrial quality control.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006816","count":1},{"id":"GO:2001256","count":1},{"id":"GO:0000422","count":1}]},{"hash":"1732268628537407451","title":"Unknown","description":"The top GO terms span sensory perception (sound) and rhodopsin biosynthesis alongside developmental processes (oogenesis, skeletal development), various catabolic glycan/lipid pathways, transcription regulation, and calcium homeostasis, showing no single cohesive biological theme for this protein set. Hence no clear, representative cluster label can be drawn.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0048477","count":3},{"id":"GO:0016063","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1060208452137144544","title":"Cytoskeleton Remodeling and Intracellular Transport","description":"This cluster is enriched for GO terms related to mitosis and cytoskeletal processes (mitotic spindle pole separation, metaphase chromosome alignment, actomyosin ring assembly, microtubule polarity) and intracellular trafficking (Golgi to plasma membrane transport, anterograde dendritic transport of receptor complexes). While a couple terms touch on signaling and immune regulation, the dominant theme across the terms is cytoskeleton dynamics and vesicular transport.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":2},{"id":"GO:0050718","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0006893","count":1},{"id":"GO:0007080","count":1}]},{"hash":"1679099204473300520","title":"Embryonic development and organ morphogenesis","description":"This cluster centers on embryonic development and organ formation, featuring placental/trophoblast differentiation, heart-related EMT and patterning, cartilage morphogenesis, and endocrine system development, with supporting transcriptional/splicing processes. The GO terms collectively point to broad developmental regulation rather than a single pathway, suggesting a general embryogenesis/morphogenesis theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0035270","count":3}]},{"hash":"2125606459139270807","title":"Neural RNA Splicing and Transcription Regulation","description":"The top GO terms are dominated by mRNA processing and spliceosome-related activities (spliceosomal tri-snRNP assembly; regulation of alternative splicing; mRNA processing) along with transcription regulation and chromatin remodeling, with a few neural-context terms (nervous system development, sensory perception). This pattern points to a cluster of proteins involved in gene expression control via RNA processing in neural development contexts.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0000244","count":2},{"id":"GO:0045087","count":2}]},{"hash":"1930273876657876522","title":"Ubiquitin-Dependent Deubiquitination and Degradation","description":"The top GO terms are dominated by deubiquitination activities (K6-linked, K48-linked, and monoubiquitinated deubiquitination) along with ubiquitin-dependent protein catabolic process, indicating a shared role in ubiquitin-mediated regulation of protein turnover; other terms about development or CNS morphogenesis are less central annotations. The lack of edges does not negate the Ub-centric theme suggested by the enriched terms, supporting a label focused on ubiquitin-related processing.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010838","count":2},{"id":"GO:0060035","count":2},{"id":"GO:0044313","count":1},{"id":"GO:0048149","count":1},{"id":"GO:0035520","count":1}]},{"hash":"1999583956427155211","title":"RNA processing and translation control","description":"The top GO terms point to post-transcriptional regulation of gene expression, especially translational initiation (both negative regulation and cap-independent initiation) and RNA processing/editing (mRNA destabilization and adenosine-to-inosine editing). While a couple of terms relate to reproduction-related processes (meiotic cell cycle, karyogamy, stem cell maintenance) which can be broader in function, the strongest signal across the cluster centers on RNA-level regulation and translation control. This supports a coherent, gene-expression\u2013level theme rather than entirely separate functions.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045947","count":2},{"id":"GO:1903679","count":1},{"id":"GO:0007329","count":1},{"id":"GO:0080009","count":1},{"id":"GO:0019827","count":1}]},{"hash":"529619849385799819","title":"Unknown","description":"The GO terms in this cluster are spread across reproduction (egg activation, male pronucleus assembly), immune response (leukocyte chemotaxis), metabolism (sterol biosynthesis), signaling (phosphatidylinositol dephosphorylation, GTPase regulation), cytoskeleton (intermediate filament organization), and development (neuron development). There is no clear, single cohesive function tying the proteins together, so a unified functional label is not supported. ","confidence":"","size":7,"edges":17,"triangles":21,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071391","count":1},{"id":"GO:0035335","count":1},{"id":"GO:0035039","count":1},{"id":"GO:0007343","count":1},{"id":"GO:0002233","count":1}]},{"hash":"1520500952986145122","title":"Potassium Transport and Membrane Potential Regulation","description":"The cluster's top GO terms are dominated by potassium ion transport and membrane potential processes (intracellular potassium homeostasis, regulation of resting membrane potential, membrane repolarization in cardiac action potential, and potassium transport), indicating a cohesive theme of cellular excitability and ion homeostasis, with some tangential terms related to cardiac remodeling or mechanosensation. Overall, the data point to a functional unit centered on ion balance and membrane potential control.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050976","count":2},{"id":"GO:0030322","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0030007","count":2},{"id":"GO:0060075","count":2}]},{"hash":"1299263571476903411","title":"Unknown","description":"The top GO terms show a mixed set: Notch signaling pathway alongside multiple amino acid catabolic and biosynthetic processes (alanine, kynurenine/tryptophan, lysine) and lipid/heme biosynthesis terms. Several terms are labeled obsolete, and there isn't a clear, unifying biological process tying all proteins together. Because the cluster appears to mix signaling and metabolism with inconsistent term labels, I cannot assign a specific, representative function.","confidence":"","size":7,"edges":12,"triangles":10,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007219","count":4},{"id":"GO:0042853","count":4},{"id":"GO:0097053","count":4},{"id":"GO:0006686","count":3},{"id":"GO:0006783","count":3}]},{"hash":"1660379308801777370","title":"Myeloid Immune Activation and Differentiation","description":"This cluster centers on signaling and regulation within the myeloid/hematopoietic lineage: dendritic cell cytokine production, myeloid progenitor differentiation, regulation of macrophage activation, integrin activation, and modulation of inflammatory mediators (IL-1) and cell activation, plus JAK-STAT signaling and megakaryocyte development. The Purkinje cell development term appears incidental noise rather than a core theme. Overall, it reflects immune cell activation and differentiation rather than a single specific process.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0021680","count":1},{"id":"GO:0042511","count":1},{"id":"GO:0045957","count":1},{"id":"GO:0035855","count":1},{"id":"GO:0033623","count":1}]},{"hash":"1067677705019830948","title":"TNF-TRAIL Extrinsic Apoptosis Signaling","description":"The cluster is driven by GO terms centered on extrinsic apoptotic signaling in the absence of ligand and positive regulation of TNF and TRAIL production, reflecting a theme of death-receptor\u2013mediated apoptosis and TNF family cytokine signaling, with some immune-regulatory context. The occasional terms about immune signaling and protein homotrimerization fit the TNF/TRAIL cytokine machinery, supporting a cohesive label around extrinsic apoptosis and TNF/TRAIL pathways.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002741","count":1},{"id":"GO:0097192","count":1},{"id":"GO:0097252","count":1},{"id":"GO:2001241","count":1},{"id":"GO:0048922","count":1}]},{"hash":"2120335660287741360","title":"Neuronal adhesion and synapse assembly","description":"Dominant GO terms point to nervous system development, neuron adhesion, and synapse assembly, including axon guidance and sensory-related terms. While a few terms touch on cardiac/bone processes, the prevailing theme is neural connectivity and synapse formation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1172286655285890784","title":"Inflammation and leukocyte chemotaxis","description":"The top GO terms point to immune signaling and leukocyte recruitment (blood coagulation, dendritic cell and monocyte chemotaxis, inflammatory mediator production, chemokine regulation), indicating a cluster of proteins involved in inflammation and immune cell trafficking. A few terms on ribosome biogenesis and translation appear but are less central. Overall, the theme is inflammatory signaling and leukocyte chemotaxis.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0002407","count":2},{"id":"GO:0090026","count":2},{"id":"GO:0042273","count":1},{"id":"GO:0006413","count":1}]},{"hash":"1628442408111030223","title":"Estrogen signaling and cytoskeletal morphogenesis","description":"This cluster is driven by estradiol response and key signaling cascades (calcineurin-NFAT, ERK), alongside lamellipodium assembly and morphogenesis (face morphogenesis), with supporting terms tied to immune cell movement (neutrophil chemotaxis, CSF stimulus). The common thread appears to be hormone- and growth-factor\u2013mediated signaling that promotes cytoskeletal remodeling and morphogenetic/ migratory processes.","confidence":"Medium","size":7,"edges":13,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032355","count":7},{"id":"GO:0051531","count":4},{"id":"GO:0070373","count":4},{"id":"GO:0030032","count":4},{"id":"GO:0010954","count":4}]},{"hash":"635887322660163849","title":"Protein homeostasis and cell cycle regulation","description":"This cluster centers on protein turnover and modification (sumoylation, ubiquitin-proteasome-related processes, deubiquitination), along with translation and mitosis/cell division, all of which relate to proteostasis and cell-cycle control. A cadmium response term supports stress-related regulation, while GnRH neuron development appears less connected.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0016925","count":2},{"id":"GO:0006412","count":2},{"id":"GO:1903071","count":2},{"id":"GO:0051301","count":2}]},{"hash":"122465636400057388","title":"Unknown","description":"The GO terms cover a wide range of unrelated processes (tRNA modification, plant anthocyanin biosynthesis, redox/obsolescent processes, hematopoietic differentiation, interleukin-1 response, protein dimethylation, vitamin E biosynthesis, etc.), with no single cohesive function uniting the cluster. This scattered functional profile suggests no clear shared theme among the proteins.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002098","count":3},{"id":"GO:0009718","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0010725","count":2},{"id":"GO:0045648","count":2}]},{"hash":"438991463851340603","title":"Amino acid metabolism (biosynthesis & catabolism)","description":"The top GO terms point strongly to amino acid metabolism, with explicit inputs for threonine, tyrosine, glutamate, alanine, and histidine pathways (catabolic or biosynthetic). While a few terms reference fatty acid biosynthesis or redox processes and several entries are obsolete, the recurring theme is amino acid turnover, making 'Amino acid metabolism' a reasonable cluster label.","confidence":"Medium","size":7,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0019518","count":4},{"id":"GO:0006571","count":3},{"id":"GO:0019551","count":3},{"id":"GO:0042853","count":3}]},{"hash":"2080842996267215300","title":"Immune signaling and antigen presentation","description":"The top GO terms point to immune-related processes: regulation of NF-kappaB, antigen processing and presentation via MHC II, and positive regulation of antibacterial peptide production. Coupled with proteolysis and ERAD-related terms, the cluster seems to link immune signaling with protein quality control, processes often intertwined during immune responses. A couple of terms (xylan catabolic process, renin-angiotensin regulation) appear ancillary or species-specific, but the core theme centers on immune surveillance and antigen handling.","confidence":"Medium","size":7,"edges":16,"triangles":14,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007253","count":2},{"id":"GO:0006397","count":2},{"id":"GO:1904378","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0045493","count":1}]},{"hash":"2091639981788429303","title":"Unknown","description":"The terms span disparate areas from translation and tRNA aminoacylation to inflammatory signaling and various catabolic processes, with no clear, cohesive functional theme tying all seven proteins together. This suggests no well-defined common function for the cluster. ","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0006425","count":1}]},{"hash":"1656950006349679580","title":"Steroid and retinoid hormone biosynthesis","description":"The GO terms cluster around biosynthesis of steroid hormones (aldosterone, cortisol, progesterone), vitamin D (calcitriol) and retinoids (9-cis-retinoic acid), with involvement of epoxygenase P450 pathways. This suggests a unifying theme of lipid/hormone synthesis and metabolism mediated by cytochrome P450 enzymes, despite a few outlier terms.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0019383","count":1},{"id":"GO:2001037","count":1},{"id":"GO:0042904","count":1},{"id":"GO:0032342","count":1},{"id":"GO:0010193","count":1}]},{"hash":"1940647403039904687","title":"Ribosome biogenesis and cell division","description":"Most terms point to ribosome biogenesis and components of translation (ribosome and tRNA modification) and to cell growth activities (cell cycle and septum assembly). While a few entries reference metabolism and stress responses, the dominant signal ties to the machinery for assembling ribosomes and supporting cell proliferation, hence the label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006400","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0000747","count":3},{"id":"GO:1901001","count":3},{"id":"GO:0039707","count":3}]},{"hash":"2235683136300311813","title":"Unknown","description":"The GO terms span inflammation, extracellular matrix organization, platelet regulation, metabolism, chloroplast targeting, RNA surveillance, and cell-cycle processes, with no clear shared function. The set is diverse and includes an obsolete term and plant-specific process, and there are no network edges to support a cohesive function, so a single, representative label is not identifiable.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0090331","count":2},{"id":"GO:0039707","count":1},{"id":"GO:0006007","count":1}]},{"hash":"1389175360039560464","title":"Unknown","description":"The top GO terms span both immune-system activities (complement activation, platelet activation, leukocyte interactions) and various developmental processes (kidney/mesonephric duct morphogenesis, lymph vessel development), with no clear single common function linking all proteins. Therefore a cohesive, specific label isn\u2019t justifiable; this cluster is best described as Unknown with None confidence.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":5},{"id":"GO:0071226","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0036303","count":4},{"id":"GO:0072287","count":4}]},{"hash":"642507487298662773","title":"Dendritic spine morphogenesis and synaptic organization","description":"The top GO term is dendritic spine morphogenesis, with several related terms pointing to neuronal development, axon regeneration, cell polarity, receptor clustering, integrin-mediated adhesion, and actin cytoskeleton dynamics, all indicative of neuronal structure formation and synaptic organization. Peripheral signals like insulin signaling and bone mineralization appear secondary to the dominant neural development theme.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":4},{"id":"GO:0048679","count":3},{"id":"GO:2000114","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0008286","count":3}]},{"hash":"1973412570717140119","title":"Neuronal axonogenesis and apoptosis regulation","description":"Top GO terms are dominated by axon development and cell fate control (axonogenesis, regulation of axon regeneration, execution phase of apoptosis, and positive regulation of programmed cell death), with supporting signals from cellular responses to stimuli and polarity. This combination suggests a cohesive theme around neuronal growth or maintenance and the regulation of survival via apoptosis pathways.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097194","count":6},{"id":"GO:0010954","count":6},{"id":"GO:0071333","count":6},{"id":"GO:0048679","count":6},{"id":"GO:0071380","count":6}]},{"hash":"711558596067669857","title":"Mitotic Cell Division and Microtubule Dynamics","description":"The dominant terms cluster around cell cycle, division, and mitotic cytokinesis, with microtubule nucleation pointing to spindle and cytoskeletal roles. Some terms on translation regulation and protein polymerization may reflect broader cellular growth, while a couple (neuron differentiation, IL-4 response) could be annotation noise. Overall, the cluster is best described as components involved in mitosis and microtubule dynamics.","confidence":"Medium","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":5},{"id":"GO:1905792","count":5},{"id":"GO:0007020","count":5},{"id":"GO:2000767","count":5},{"id":"GO:0030182","count":5}]},{"hash":"621242355955763846","title":"Tissue and Neural Development","description":"The top terms point to developmental processes across multiple tissues and cell types\u2014axonogenesis, myoblast fusion, Schwann cell development, heart development, and visual perception\u2014suggesting a theme of broad morphogenesis and tissue-specific differentiation. Regulatory signals (phosphorylation, apoptotic regulation, hormonal responses) further support a cluster centered on developmental control rather than a single pathway. While some terms (e.g., abscisic acid signaling) may reflect annotation breadth or cross-kingdom data, the dominant pattern is cross-tissue development and differentiation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010800","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0007601","count":3}]},{"hash":"1859761199447195205","title":"Glycolysis and glycogen catabolism","description":"The cluster is enriched for terms tied to carbohydrate metabolism and energy production, especially canonical glycolysis and glycolysis from storage polysaccharides (glucose-1-phosphate), along with glycogen catabolic process and fructose-6-phosphate metabolism. These collectively indicate functions in glycolytic energy yield and mobilization of glucose from glycogen. Some minor terms (uracil catabolic process, nitrogen utilization, creatinine catabolic process) are peripheral and do not define the core theme. ","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":3},{"id":"GO:0061621","count":2},{"id":"GO:0093001","count":2},{"id":"GO:0006002","count":2},{"id":"GO:0005980","count":2}]},{"hash":"973365135005253059","title":"Cell Cycle Regulation","description":"Most frequent terms are cell division and cell cycle, indicating proteins involved in cell cycle progression; secondary hints (GPCR/cAMP signaling and vesicle transport) suggest supporting regulatory and trafficking roles, but the core theme is cell cycle control.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0030817","count":3},{"id":"GO:1903554","count":3},{"id":"GO:0010353","count":3}]},{"hash":"792427923047886141","title":"RNA Modification Enzymes","description":"These proteins cluster around RNA modification activities: tRNA methylation and wobble uridine modification, rRNA modification, and mRNA capping, indicating a core function in RNA maturation and processing. Auxiliary terms related to protein modification and aging appear as secondary associations, but the dominant theme points to RNA modification enzymes. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0018027","count":2},{"id":"GO:0010189","count":2},{"id":"GO:1901052","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0002098","count":2}]},{"hash":"2069441967304608360","title":"Actin Cytoskeleton Remodeling and Endocytosis","description":"The cluster centers on actin-driven processes: phagocytosis and endocytosis regulation, postsynaptic and general actin cytoskeleton organization, and assembly of actin-based structures (skeletal muscle thin filaments and the mitotic contractile ring). This points to a cohesive function in actin remodeling that coordinates membrane trafficking, cell division, and cytoskeletal architecture.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006909","count":6},{"id":"GO:0043981","count":6},{"id":"GO:0009825","count":6},{"id":"GO:0030240","count":6},{"id":"GO:1903475","count":6}]},{"hash":"1564269130517254565","title":"RNP Biogenesis and RNA Processing","description":"The cluster centers on RNA-protein complexes and RNA maturation, with GO terms for ribosome biogenesis, snRNA/pseudouridine synthesis, box H/ACA snoRNP assembly, and telomerase RNA stabilization/localization/assembly. These point to assembly and modification of RNPs (snoRNPs, telomerase) and related transcription- and chromatin-related RNA processing steps. A single outlier term (GABA transport) is likely noise. Overall, the theme is coherent around RNA processing and RNP biogenesis.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0031120","count":1},{"id":"GO:0000454","count":1},{"id":"GO:0000493","count":1},{"id":"GO:0090669","count":1}]},{"hash":"2290029955430280406","title":"Neural signaling and vascular regulation","description":"The top GO terms point to neurotransmitter signaling (dopamine secretion, GABAergic transmission, dopamine receptor signaling, acetylcholine metabolism) and signaling cascades (ERK, Rho). The presence of vascular-related terms (blood coagulation, angiogenesis regulation, blood pressure control) suggests cross-talk between neural signaling and vascular pathways. Together, these proteins likely participate in coordinating neural signals with vascular dynamics, hence the label Neural signaling and vascular regulation. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0032228","count":2},{"id":"GO:0035025","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0014059","count":2}]},{"hash":"2000262134341138036","title":"Unknown","description":"The top terms span transcription regulation, sarcomere organization, ubiquitin pathways and protein turnover, ER targeting, interferon response, and signaling regulation, with no clear shared function or network connectivity. This heterogeneity prevents a concise, representative label.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0030433","count":1},{"id":"GO:0000160","count":1},{"id":"GO:0006355","count":1}]},{"hash":"410953143922111232","title":"Multisystem Development and Morphogenesis","description":"The proteins in this cluster are annotated with GO terms spanning neural differentiation (medial motor column neuron differentiation), heart development (atrial cardiac muscle cell development), kidney development (nephric duct elongation, nephron tubule epithelial cell differentiation), immune regulation (regulation of T cell homeostatic proliferation), and cell motility (lamellipodium assembly), plus examples from plants (seed morphogenesis) and insects (positive regulation of eclosion). The common thread is developmental processes and tissue morphogenesis across diverse systems, rather than a single specific function. This broad cross-tissue theme explains the mix of terms and makes a single, precise function label challenging, hence the multisystem development-oriented name.","confidence":"Medium","size":6,"edges":8,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0021526","count":3},{"id":"GO:0030032","count":3},{"id":"GO:2000346","count":3},{"id":"GO:0045805","count":3}]},{"hash":"305191295680964493","title":"Mitochondrial dynamics and innate immune signaling","description":"Several top GO terms point to mitochondrial morphogenesis, inner membrane organization, and inheritance (mitochondrial dynamics), suggesting a mitochondrial-centric module. Additional terms involve positive regulation of TLR3 signaling and interleukin-2 production, hinting at potential cross-talk between mitochondrial function and innate immune pathways. Some terms (extracellular matrix disassembly, cholesterol biosynthesis regulation) are less central. Overall, the core signal is mitochondria with possible immune signaling interactions, so the name reflects the main theme with caveats.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045541","count":3},{"id":"GO:0070584","count":3},{"id":"GO:1990046","count":3},{"id":"GO:0034141","count":3},{"id":"GO:0022617","count":3}]},{"hash":"2266563167298341419","title":"Zinc Ion Transport and Homeostasis","description":"The proteins show a consistent pattern around zinc handling\u2014zinc import across membranes, intracellular zinc homeostasis, detoxification of zinc, and responses to zinc ion starvation\u2014suggesting a functional cluster dedicated to zinc uptake and maintenance, with a minor outlier term (limb development) likely unrelated. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006830","count":1},{"id":"GO:0044749","count":1},{"id":"GO:0070574","count":1},{"id":"GO:0034224","count":1},{"id":"GO:0060173","count":1}]},{"hash":"54814535443135749","title":"Axon guidance and synapse organization","description":"This cluster is enriched for neural connectivity processes: axonal fasciculation, axon guidance, and synapse organization are dominant GO terms, suggesting functional coherence in nervous system development and neural connectivity. Other terms (morphogenesis, vascular signaling, immune regulation) are less central but compatible with broad developmental contexts.","confidence":"Medium","size":6,"edges":8,"triangles":1,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":4},{"id":"GO:0007411","count":3},{"id":"GO:0006936","count":3},{"id":"GO:0048701","count":3},{"id":"GO:2000830","count":3}]},{"hash":"1325266601951038461","title":"Metanephric kidney development","description":"The top GO terms are dominated by metanephric development: distal tubule morphogenesis, proximal tubule development, ascending limb development, and mesonephric duct development, pointing to embryonic kidney morphogenesis. Additional terms about lymph vessel morphogenesis and leukocyte interactions appear as secondary themes or noise. Overall, the cluster aligns with metanephric kidney development.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":1},{"id":"GO:0072287","count":1},{"id":"GO:0010572","count":1},{"id":"GO:0072218","count":1},{"id":"GO:0090403","count":1}]},{"hash":"893307411110659506","title":"Plant developmental transcription regulation and histone acetylation","description":"The top terms cluster around transcription (DNA-templated transcription and its regulation) and histone acetylation, with developmental processes such as microgametogenesis and somatic embryogenesis also represented, suggesting a cohesive role in chromatin modification and transcription control during plant development.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055046","count":1},{"id":"GO:0045466","count":1},{"id":"GO:0010262","count":1},{"id":"GO:0043981","count":1},{"id":"GO:0006355","count":1}]},{"hash":"526293225396925734","title":"Unknown","description":"The terms span many distinct processes (receptor clustering, GPCR signaling, epithelial and keratinocyte development, placental morphogenesis, visual perception, surfactant homeostasis, fibrinolysis, ovarian follicle development, macrophage regulation), with little cohesive function tying them together. This diversity suggests no single, interpretable cluster function can be confidently assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":2},{"id":"GO:0043129","count":2},{"id":"GO:0042730","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0071073","count":2}]},{"hash":"1154372438651167209","title":"Unknown","description":"The top GO terms are highly diverse (innate immune response, developmental processes in multiple organs, cell cycle regulation, chlorophyll biosynthesis, and drug/ion responses) with no single shared function, plus zero edges linking the proteins, making it unlikely to represent a cohesive biological module.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0055059","count":2},{"id":"GO:0007346","count":2},{"id":"GO:0071909","count":2},{"id":"GO:1902325","count":2}]},{"hash":"1863865665574395396","title":"Unknown","description":"The top terms are highly diverse (neural fold formation, thrombocyte differentiation, interleukin-6 production, cell cycle regulation, gluconeogenesis regulation, etc.) with several obsolete terms, showing no single cohesive function. As a result, there isn\u2019t a clear shared theme to label the cluster beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035948","count":2},{"id":"GO:1903699","count":1},{"id":"GO:2000219","count":1},{"id":"GO:0044154","count":1},{"id":"GO:0001842","count":1}]},{"hash":"1787158227796206982","title":"Unknown","description":"The GO terms mix carbohydrate metabolism (chitin catabolic process, carbohydrate metabolic process) with inflammatory signaling (production of molecular mediator involved in inflammatory response, positive regulation of chemokine production) but there is no coherent, strongly supported shared function across the proteins (no edges or connectivity), so a definite, intuitive label cannot be determined.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0090197","count":1}]},{"hash":"2234097161389754878","title":"Diverse Substrate Transporters","description":"The top GO terms point to a family of membrane transport activities across a wide range of substrates: nitrate transmembrane transport, sialic acid transport, various sugar transports (galactose, arabinose, fucose), vitamin transport, and even neurotransmitter loading into synaptic vesicles. This pattern strongly indicates a cluster of transport proteins with broad substrate specificity rather than a single-pathway function, justifying a label centered on diverse substrate transport activity.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0035461","count":2}]},{"hash":"1118178711819592567","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":2},{"id":"GO:0060999","count":2},{"id":"GO:0071803","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0043547","count":2}]},{"hash":"681483160409752974","title":"mRNA processing and translation initiation regulation","description":"The cluster focuses on regulation of mRNA stability and poly(A) tail dynamics, along with multiple facets of translation initiation (including preinitiation complex formation and IRES-mediated initiation) and ribosome-associated processing (small-subunit processome), suggesting a cohesive theme of controlling mRNA fate and the start of protein synthesis.","confidence":"High","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":4},{"id":"GO:0060211","count":3},{"id":"GO:0006446","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0000381","count":3}]},{"hash":"380970356721853830","title":"Ribosome biogenesis and rRNA maturation","description":"The cluster is strongly enriched for ribosome-related processes, with multiple terms for maturation and biogenesis of both LSU- and SSU-rRNA, and general ribosomal subunit assembly. Other terms like mRNA splicing, ubiquitination, and development appear but do not define the cluster\u2019s main theme; overall these proteins appear linked to ribosome production and rRNA processing.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0000463","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000466","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0000209","count":6}]},{"hash":"1016352750296141855","title":"Unknown","description":"The GO terms span coagulation, proteostasis, immune signaling, cell adhesion, neural regeneration, development, and plant reproduction, with no single coherent theme across the cluster. The diversity suggests there isn\u2019t a shared core function to label succinctly, so a precise, representative name cannot be determined.","confidence":"","size":6,"edges":7,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0006511","count":4},{"id":"GO:0002291","count":4},{"id":"GO:0007161","count":4},{"id":"GO:0031104","count":4}]},{"hash":"2117896361723300195","title":"Mechanotransduction and Calcium Signaling","description":"The terms center on sensing and responding to mechanical stimuli (cellular response to mechanical stimulus, detection of mechanical stimulus) and involve calcium signaling and kinase pathways (calcium ion import, GPCR/PKC signaling, kinase activity regulation), with supporting processes like cell migration and ubiquitination. While some GO terms are obsolete or immune-related, the core pattern is mechanical cue sensing linked to signaling and cytoskeletal remodeling. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0016477","count":4}]},{"hash":"2005628399622046227","title":"ER-Golgi Vesicle Transport and Pigmentation","description":"Top GO terms indicate core vesicle trafficking between ER and Golgi (COPII coating; ER-to-Golgi; intra-Golgi transport) with supportive involvement in autophagy and pigment-related melanosome assembly/pigmentation, suggesting a cohesive theme of intracellular vesicle transport linked to pigment granule formation. A few unrelated terms (DNA replication) appear as noise. Confidence: High","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048208","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0042338","count":1},{"id":"GO:0006891","count":1},{"id":"GO:0006914","count":1}]},{"hash":"2197091087108887679","title":"Kidney tubule and duct morphogenesis","description":"GO terms are largely about metanephric kidney development, including distal and proximal tubule morphogenesis and mesonephric duct development, with related metanephric limb development terms. A few terms touch on immune or vascular processes, but the dominant theme is embryonic kidney morphogenesis.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":1},{"id":"GO:0072287","count":1},{"id":"GO:0010572","count":1},{"id":"GO:0072218","count":1},{"id":"GO:0090403","count":1}]},{"hash":"873947213037680531","title":"Splicing Regulation and RNA Processing","description":"The top GO terms cluster around mRNA splicing and spliceosome-driven regulation (GO:0000380, GO:0048026), with additional signals for RNA processing and ncRNA-mediated gene silencing, suggesting a primary theme of RNA maturation and splicing control. Peripheral terms like xenobiotic response and rRNA maturation exist but are less central to the main theme. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000380","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0006289","count":3},{"id":"GO:0016575","count":3}]},{"hash":"1022636561260695461","title":"Unknown","description":"The terms are diverse (retinol and galactose metabolism, immune response to LPS, transcription regulation, development, redox/oxidation, copper ion response, respiratory and gland development) with no clear shared function. Several GO terms are obsolete, indicating no cohesive functional theme for this cluster. Therefore, no reliable single label can be assigned.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042572","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0042208","count":2}]},{"hash":"1249900443788391634","title":"Bacterial cell wall and capsule biosynthesis","description":"The top GO terms heavily point to assembly of cell envelope components: capsule polysaccharide biosynthesis, peptidoglycan biosynthetic process, and cell wall organization. These together strongly suggest a shared function in bacterial cell wall/capsule biosynthesis. Some other terms (redox processes, amino acid/cytokinin catabolism) appear more peripheral or cross-species annotation noise, not defining the core theme. ","confidence":"High","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006574","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0009823","count":2},{"id":"GO:0007049","count":2}]},{"hash":"1841562001648876971","title":"Embryonic organogenesis and vascular development","description":"Reason: The terms cluster around morphogenesis of multiple organs (cartilage, kidney/mesonephros, lymphatics) and associated vascular/immune processes (blood coagulation, platelet activation, leukocyte rolling), pointing to a broad theme of embryonic organogenesis with vascular development.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":3},{"id":"GO:0036303","count":2},{"id":"GO:0072287","count":2},{"id":"GO:0010572","count":2},{"id":"GO:0072218","count":2}]},{"hash":"1952349187067966123","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006189","count":1},{"id":"GO:0071268","count":1},{"id":"GO:0008615","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0009099","count":1}]},{"hash":"812431822764961227","title":"Unknown","description":"The top GO terms are highly diverse, spanning immune differentiation, cell migration, kinase regulation, calcium transport, endocytosis, telomere dynamics, and membrane depolarization, with no clear shared function linking all proteins.","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002268","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0071901","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0048549","count":3}]},{"hash":"19629744518627452","title":"Auditory synaptic transmission","description":"The terms cluster around hearing-related neural signaling: ion transport and membrane depolarization drive synaptic activity; excitatory postsynaptic potentials and glycinergic transmission are central to auditory neurons; sensory perception of sound and vestibulocochlear nerve development reinforce a hearing-focused function. A few terms are less directly related but do not override the main theme.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051899","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0007605","count":3}]},{"hash":"2015586399404923928","title":"Metal-Stress Ubiquitin-Proteasome Regulation","description":"This cluster centers on ubiquitin-mediated proteolysis, with several GO terms for protein ubiquitination, SCF-dependent proteasomal degradation, and ubiquitin-dependent catabolic processes. The metal-response terms (arsenic, cadmium, methylmercury) suggest a stress context in which ubiquitination regulates protein turnover to cope with metal toxicity. The circadian regulation and synapse assembly terms may reflect broader regulatory roles in cells and neurons, but the dominant signal is ubiquitin-proteasome\u2013mediated degradation, especially under metal stress.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1902916","count":1},{"id":"GO:0046685","count":1},{"id":"GO:0071406","count":1},{"id":"GO:0071276","count":1},{"id":"GO:0031146","count":1}]},{"hash":"1503887897656204427","title":"Eye Development and Pigmentation","description":"Based on the top GO terms, there is a clear tilt toward ocular development and pigmentation, including ciliary body morphogenesis, eye pigmentation, and melanin metabolism, with some related endothelial cell migration that could pertain to ocular vasculature. While DNA repair (base-excision repair) and nuclear transport (NLS-bearing protein import into nucleus) terms appear, they are less specific to this cluster\u2019s main theme, so the label reflects the strongest shared function among the proteins.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006284","count":1},{"id":"GO:0097510","count":1},{"id":"GO:0006607","count":1},{"id":"GO:0061428","count":1},{"id":"GO:0060438","count":1}]},{"hash":"299915599031833076","title":"Cholesterol metabolism and transport","description":"The Top Terms are dominated by cholesterol-related processes (cholesterol metabolic process, intracellular cholesterol transport, cholesterol efflux, lipid storage), indicating a shared function in cholesterol handling and lipid metabolism. Several other terms point to broader lipid catabolism, fitting the same general theme, though a few outliers (LPS response, necroptotic process) do not alter the main lipid-centric pattern.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043420","count":1},{"id":"GO:0019441","count":1},{"id":"GO:0008203","count":1},{"id":"GO:0032367","count":1},{"id":"GO:0070266","count":1}]},{"hash":"2299592472631661470","title":"Ribosome Biogenesis and Stress Signaling","description":"The top GO terms indicate ribosome biogenesis and activation of protein kinase activity, with concurrent oxidative stress response, suggesting a theme where protein synthesis processes are linked to signaling pathways and cellular stress responses. This points to a cohesive cluster involved in ribosome assembly alongside kinase-driven stress signaling and protective responses.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0032147","count":2},{"id":"GO:0006979","count":2},{"id":"GO:0051583","count":1},{"id":"GO:0032091","count":1}]},{"hash":"1789782544587742187","title":"Calcium-NFAT Signaling and Transcription Regulation","description":"This cluster centers on calcium-dependent signaling (calcineurin-NFAT and calcium-modulating pathways) together with transcriptional activation (RNA Pol II) and nuclear import, suggesting a module where calcium signals regulate gene expression via nuclear access, especially under stress-related contexts like cardiac hypertrophy, angiogenesis, and hypoxia. Some terms, such as cuticle development, seem unrelated and likely reflect annotation noise.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0051531","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0010800","count":3},{"id":"GO:1903244","count":3}]},{"hash":"824531925255390014","title":"Hypoxia-induced angiogenesis","description":"The top terms are dominated by angiogenesis and branching in blood vessels, plus a hypoxia response, indicating a module of proteins coordinating vascular development under low-oxygen conditions. Regulatory signals such as NFAT/calcineurin, transcriptional regulation, and phosphorylation further support a signaling/ transcriptional control cluster tied to angiogenesis rather than a metabolic module.","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":4},{"id":"GO:0001569","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0051531","count":2}]},{"hash":"752863380453636397","title":"Beta-lactam Antibiotic Catabolism and Beta-lactamase Regulation","description":"This cluster is dominated by GO terms relating to degradation/catabolism of beta-lactam antibiotics and regulation of beta-lactamase activity, with additional signals of antibiotic response, suggesting a coherent theme of antibiotic degradation and resistance regulation among the proteins.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030655","count":3},{"id":"GO:0019876","count":3},{"id":"GO:0033252","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0097194","count":2}]},{"hash":"1684666291407911288","title":"Circadian Transcription Regulation","description":"The top GO terms are strongly centered on circadian rhythm regulation and transcription (positive regulation of circadian rhythm, DNA-templated transcription, circadian regulation of gene expression), pointing to proteins that regulate circadian gene expression. Other terms related to hormonal signaling and lipid metabolism appear only sparsely, and do not define the main theme of the cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042753","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0032922","count":2},{"id":"GO:0071391","count":1},{"id":"GO:0070328","count":1}]},{"hash":"1141418124212896105","title":"Tendon, skin, and podocyte development","description":"The top GO terms include tendon development, skin morphogenesis, and positive regulation of metanephric podocyte development, which together indicate tissue-specific development programs across connective tissue, skin, and kidney. There are outliers related to lipoprotein processing and immune pathways, but the strongest cohesive theme is tissue morphogenesis. ","confidence":"Medium","size":5,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045715","count":1},{"id":"GO:0035989","count":1},{"id":"GO:2000860","count":1},{"id":"GO:0034381","count":1},{"id":"GO:2000478","count":1}]},{"hash":"1679052864205226163","title":"Membrane sugar and ion transporters","description":"The cluster's GO terms predominantly reflect transmembrane transport of sugars (galactose, fructose, arabinose, sialic acid) and various ions (potassium, phosphate, nitrate), plus osmotic stress and glucose starvation responses. This pattern points to membrane transport proteins involved in nutrient uptake and osmoregulation, hence the label.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":1},{"id":"GO:0015757","count":1},{"id":"GO:1990539","count":1},{"id":"GO:0006970","count":1},{"id":"GO:0015751","count":1}]},{"hash":"1995524007781579307","title":"Actin Cytoskeleton Remodeling and Endocytosis","description":"The top GO terms cluster around actin-based processes: postsynaptic and cytokinetic actin organization, muscle thin filament assembly, and phagocytosis/endocytosis regulation, all pointing to actin cytoskeleton remodeling coupled with membrane trafficking. Some unrelated terms (histone acetylation) appear as minor references, but the dominant signal describes actin dynamics and endocytic regulation.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006909","count":3},{"id":"GO:0043981","count":3},{"id":"GO:0009825","count":3},{"id":"GO:0030240","count":3},{"id":"GO:1903475","count":3}]},{"hash":"1943952162229349515","title":"Anthocyanin and lignin biosynthesis","description":"The top GO terms show strong enrichment for anthocyanin-containing compound biosynthesis and cyanidin 3-O-glucoside biosynthetic processes, along with lignin metabolic processes. These point to the phenylpropanoid pathway producing flavonoid pigments and lignin, with auxiliary terms (like antibiotic biosynthesis and genistein response) likely reflecting related secondary metabolite pathways or cross-references. Overall, a cohesive theme of plant secondary metabolite biosynthesis, especially flavonoids and lignin, is evident.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0006711","count":2},{"id":"GO:0033485","count":2}]},{"hash":"2010059327470986109","title":"Ubiquitin-Mediated Degradation and JNK Regulation","description":"This cluster is dominated by GO terms related to ubiquitination (autoubiquitination, K63-linked ubiquitination) and ubiquitin-dependent protein catabolic processes, including both positive and negative regulation, plus the GO term for regulation of the JNK cascade. The combination points to proteins involved in tagging substrates for degradation and modulating JNK signaling, indicating a cohesive ubiquitin-regulated functional theme rather than disparate processes.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":5},{"id":"GO:0070534","count":5},{"id":"GO:0046328","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0060669","count":3}]},{"hash":"365341338134480291","title":"Peptidoglycan turnover and Gram-positive defense","description":"The cluster centers on bacterial cell wall processes (peptidoglycan turnover/catabolic and cell wall organization) coupled with host defense responses against Gram-positive bacteria, including detection of bacteria and antibacterial peptide production.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044117","count":1},{"id":"GO:0071555","count":1},{"id":"GO:0032827","count":1},{"id":"GO:0016045","count":1},{"id":"GO:0061060","count":1}]},{"hash":"822412040387556164","title":"GTPase and TORC1 Nutrient Signaling","description":"The top GO terms point to GTPase activity regulation and heterotrimerization of G proteins, glucose- and nutrient-responsive signaling, and TORC1 pathway regulation, with vesicle trafficking and development terms adding context. Together they suggest a cohesive theme of signaling networks that sense nutrients (glucose) and regulate growth via GTPases and TORC1, linking trafficking and development to growth control.","confidence":"Medium","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0010255","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1162521167935497151","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0045892","count":3},{"id":"GO:0048813","count":3},{"id":"GO:0044209","count":3}]},{"hash":"1330401542329569700","title":"Negative Regulation of Signaling Pathways","description":"The GO terms point to dampening of signaling across diverse contexts\u2014ERK1/2 cascade, IL-6 production/signaling, insulin receptor signaling, and related immune/neural processes. Some terms also touch on neuronal development and hematopoietic lineage regulation, suggesting a broader role in inhibiting signaling events rather than specific pathway activation. No edges are shown, but the recurring theme is negative regulation of signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":2},{"id":"GO:0048679","count":2},{"id":"GO:0034165","count":2},{"id":"GO:1900165","count":2},{"id":"GO:0035855","count":2}]},{"hash":"288888367364834053","title":"Carbohydrate Catabolism and Related Metabolism","description":"The GO terms cluster around carbohydrate breakdown and related energy pathways, including pentose-phosphate shunt activity and catabolism of glucosamine, N-acetylglucosamine, and neuraminic acid, plus proteolysis. A couple terms relate to more distant processes (telomere maintenance, mitochondrial RNA modification), so the label best captures the core theme without overfitting.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0000722","count":1},{"id":"GO:0072670","count":1},{"id":"GO:0046944","count":1}]},{"hash":"1347842798865905995","title":"Cell Adhesion and Signaling","description":"The top GO terms are dominated by integrin-mediated signaling and cell-matrix/heterotypic adhesion, with additional terms for T cell activation and coagulation; though ubiquitin-dependent proteolysis and proteasome assembly also appear, the common thread across most terms is adhesion-related signaling and matrix interactions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0006511","count":4},{"id":"GO:0002291","count":4},{"id":"GO:0007161","count":4}]},{"hash":"698241047860331535","title":"Diverse cellular stimulus responses","description":"This cluster shows enrichment for multiple distinct stimulus-response terms (glucose stimulus, estradiol, TNF, dsRNA) along with related metabolic, signaling, and transport processes (insulin secretion regulation, potassium import, cardiac relaxation, pigment granule dispersal, BMP signaling regulation, and protein oligomerization). The commonality is broad\u2014proteins involved in responding to diverse cellular cues rather than a single cohesive pathway\u2014so a label like \u201cDiverse cellular stimulus responses\u201d best captures the cluster's overall theme.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":3,"top_function":"nervous system process","top_go_terms":[{"id":"GO:0071333","count":5},{"id":"GO:0043330","count":5},{"id":"GO:0055119","count":4},{"id":"GO:0032355","count":3},{"id":"GO:0051876","count":3}]},{"hash":"1034799910641522456","title":"Inflammation and Signal Transduction","description":"A set of terms centers on immune/inflammatory regulation (defense against bacteria; negative regulation of inflammatory response) while also highlighting broad signaling pathways (ERK/MAPK cascade; GPCR-related dopamine signaling) and cellular processes (membrane potential, proteolysis), suggesting proteins involved in inflammatory signaling with neural and cardiovascular signaling components.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":2},{"id":"GO:0043278","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0050728","count":2},{"id":"GO:0042391","count":2}]},{"hash":"2212502502014837606","title":"Translation initiation and ribosome export","description":"The GO terms cluster around translation initiation\u2014formation of preinitiation and initiation complexes, cap-dependent and IRES-dependent initiation, and export of ribosomal subunits\u2014indicating a shared role in initiating protein synthesis. A couple of differentiated-cell terms appear as noise, but the dominant theme is translation machinery.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061101","count":1},{"id":"GO:0000055","count":1},{"id":"GO:1902416","count":1},{"id":"GO:0001732","count":1},{"id":"GO:0006446","count":1}]},{"hash":"966478986842746638","title":"Ubiquitin-Dependent Turnover and NF-kappaB/JNK Regulation","description":"The top GO terms cluster around ubiquitin-dependent protein catabolism and regulation of signaling pathways, especially NF-kappaB and JNK cascades, as well as apoptosis. Terms such as ubiquitin-dependent protein catabolic process, protein autoubiquitination, regulation of JNK cascade, and activation of NF-kappaB-inducing kinase point to ubiquitin-mediated control of cell survival signaling. Some items (e.g., dosage compensation, viral material transport regulation) are peripheral, but the dominant theme is ubiquitin-mediated regulation of signaling and apoptosis, justifying this label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:1903265","count":4},{"id":"GO:1903762","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0046328","count":4}]},{"hash":"1080131746816167732","title":"Actin Cytoskeleton Remodeling","description":"The cluster is dominated by GO terms describing actin dynamics (ruffle assembly, stress fiber and actin filament polymerization) and cellular responses to mechanical stimuli, indicating a primary theme of actin remodeling and cell motility. Some vesicle trafficking terms appear, but the strongest signal is actin-driven structural rearrangement. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0097178","count":3},{"id":"GO:0051496","count":3},{"id":"GO:1902236","count":3},{"id":"GO:1903215","count":3}]},{"hash":"262183619244867582","title":"Neuronal sphingolipid metabolism and synaptic function","description":"This cluster combines lipid metabolism terms centered on sphingolipids (ceramide catabolic, sphingosine biosynthesis/catabolic) with neural/synaptic contexts (synaptic vesicle fusion, Purkinje cell layer development). The presence of long-chain fatty acid biosynthesis reinforces a lipid-centric theme in neurons, suggesting a role in membrane dynamics and neurotransmission. A few terms like dorsal closure or hatching behavior appear less connected and may reflect broader annotations, but the core theme remains neuronal lipid metabolism and synaptic activity.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031629","count":1},{"id":"GO:0046514","count":1},{"id":"GO:0035187","count":1},{"id":"GO:0046512","count":1},{"id":"GO:0042759","count":1}]},{"hash":"854490829486563465","title":"Embryonic Tissue Morphogenesis","description":"Most terms describe embryonic development and morphogenesis in diverse tissues (forebrain, hindlimb, inner ear, skull, digestive tract, pancreas, uterus). The common thread is tissue morphogenesis during embryogenesis rather than a single specific pathway, so Embryonic Tissue Morphogenesis is a concise, representative label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0048565","count":2},{"id":"GO:0048853","count":2}]},{"hash":"460033130914622449","title":"Unknown","description":"The top terms are a mix of DNA repair (mismatch repair, negative regulation of DNA recombination) and a variety of transport-related processes (sialic acid, nitrate, galactose, fucose, vitamin transport, and even neurotransmitter loading), with one obsolete annotation. This diversity does not reveal a coherent single function or pathway tying the proteins together, so a single interpretable label is not supported.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006298","count":1},{"id":"GO:0045910","count":1},{"id":"GO:0015739","count":1},{"id":"GO:0015706","count":1},{"id":"GO:0042891","count":1}]},{"hash":"1650599377355448143","title":"Unknown","description":"The top GO terms are dispersed across development, reproduction, metabolism, and immune-related processes (e.g., embryonic digestive tract development, sperm capacitation, hatching and larval behaviors, insulin processing, LDL receptor-related processes, cytokine production), and there are no network connections (edges) tying them into a single coherent function. This lack of a clear, shared theme makes a specific, representative label untenable.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048566","count":2},{"id":"GO:0042089","count":2},{"id":"GO:0035187","count":2},{"id":"GO:0030070","count":2},{"id":"GO:0032802","count":2}]},{"hash":"1466424642745211852","title":"Calcium-Dependent Cardiac and Vascular Signaling","description":"The top GO terms point to calcium-regulated signaling pathways (calcineurin-NFAT, calcium-modulating Wnt pathway) that influence cardiac hypertrophy, cardiac contraction via calcium release, and vascular branching, with additional roles in phosphorylation and GTPase regulation. Together these terms suggest a cohesive module centered on calcium-mediated signaling in heart and blood vessels, with broader regulatory connections to exocytosis and transcriptional control.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0010800","count":3},{"id":"GO:1903244","count":3},{"id":"GO:0007223","count":3}]},{"hash":"1970555841478035873","title":"RNA metabolism and translation regulation","description":"These proteins show GO terms that converge on RNA-level control of gene expression, including transcriptional regulation, mRNA processing/splicing, poly(A) tail regulation, and initiation/reinitiation of translation (with links to stress responses like hypoxia). This suggests a cohesive cluster centered on coordinating transcription and translation through RNA processing steps.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0006351","count":2}]},{"hash":"771607759079261442","title":"mRNA processing and translational control","description":"The top GO terms cluster around mRNA maturation (poly(A) tail shortening, alternative splicing, small-subunit processome) and the initiation of translation (preinitiation complex formation, IRES-dependent initiation). This suggests the proteins act together to regulate RNA processing and the start of protein synthesis, including viral translation mechanisms. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0060211","count":4},{"id":"GO:0006446","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0000381","count":4},{"id":"GO:0001731","count":4}]},{"hash":"1733954316965249587","title":"Ubiquitin-mediated protein degradation","description":"The top GO terms are dominated by ubiquitination processes (monoubiquitination, autoubiquitination, K48- and K6-linked ubiquitination) and ubiquitin-dependent protein catabolic pathways, indicating a cluster centered on ubiquitin-tagged protein turnover; a few peroxisome-related terms appear but are less central to the core function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016558","count":2},{"id":"GO:0006513","count":2},{"id":"GO:0031648","count":2},{"id":"GO:1903265","count":2},{"id":"GO:0051865","count":2}]},{"hash":"335316683488726126","title":"Unknown","description":"The GO terms are diverse: regulation of BMP signaling and osteoclast differentiation suggest development/bone biology, but the cluster also includes transmembrane transport of sugars and immune-related regulation, with no clear shared function. Because there is no cohesive theme tying these terms together, this cluster should be labeled Unknown.","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002787","count":1},{"id":"GO:0019800","count":1},{"id":"GO:0015757","count":1},{"id":"GO:0001970","count":1},{"id":"GO:0045671","count":1}]},{"hash":"1652198228554131818","title":"Spliceosome Components","description":"Most of the prominent GO terms are about RNA splicing and spliceosome assembly (splicing via spliceosome, spliceosomal tri-snRNP complex assembly, RNA splicing, mRNA processing), indicating the cluster captures proteins involved in pre-mRNA splicing and spliceosome machinery. A few other terms exist but are not central to the cluster\u2019s main function. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0000244","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0008380","count":1},{"id":"GO:1905705","count":1}]},{"hash":"1027101975711145887","title":"P450-Mediated Steroid and Retinoid Metabolism","description":"The top GO terms cluster around biosynthesis of steroid hormones (aldosterone, cortisol, progesterone), calcitriol (vitamin D), and 9-cis-retinoic acid, all products of cytochrome P450\u2013mediated metabolism. The presence of the epoxygenase P450 pathway and xenobiotic-related terms (camphor catabolic process, ozone response) further supports a cohesive theme of P450-driven lipid and vitamin metabolism, justifying a label focused on this shared function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019383","count":4},{"id":"GO:2001037","count":4},{"id":"GO:0042904","count":4},{"id":"GO:0032342","count":4},{"id":"GO:0010193","count":4}]},{"hash":"2075529440284396763","title":"Histone acetylation and heterochromatin regulation","description":"The cluster\u2019s top GO terms are dominated by histone acetylation (H4-K5, H4-K12, and H3 acetylation) and heterochromatin formation/boundary maintenance, suggesting a core theme of chromatin modification and heterochromatin regulation. Some related terms (e.g., cellular senescence) can be linked to heterochromatin changes, supporting a chromatin-focused interpretation despite a few peripheral terms.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043981","count":1},{"id":"GO:0071392","count":1},{"id":"GO:0043983","count":1},{"id":"GO:0000183","count":1},{"id":"GO:0031453","count":1}]},{"hash":"1793850676169236371","title":"RNA processing and translation initiation regulation","description":"The top GO terms cluster around RNA maturation and control of translation initiation: mRNA deadenylation, regulation of translational initiation, spliceosome-mediated splicing, formation of the translation preinitiation complex, IRES-dependent viral translation, and small-subunit processome assembly, suggesting a cohort involved in RNA processing and initiation of translation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0060211","count":4},{"id":"GO:0006446","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0000381","count":4},{"id":"GO:0001731","count":4}]},{"hash":"19375970012276188","title":"Oxidative stress response and immune signaling","description":"The GO terms include removal of superoxide radicals, cellular response to selenium ion, and positive regulation of interferon-beta production, which collectively point to defense against oxidative stress and immune signaling. Although translation-related terms appear, they are less defining for the cluster than the stress- and immune-related terms, making an oxidative stress/immune signaling theme the most representative. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0042797","count":1},{"id":"GO:0032728","count":1},{"id":"GO:0019430","count":1},{"id":"GO:0001302","count":1}]},{"hash":"2006175406830261063","title":"RNA Splicing and Translation Regulation","description":"Based on the prominent GO terms\u2014mRNA splicing via spliceosome and its regulation, regulation of mRNA stability in stress, regulatory ncRNA-mediated gene silencing, poly(A) tail regulation, and translation initiation/preinitiation complex formation\u2014the cluster appears to center on post-transcriptional RNA processing and control of translation, indicating a cohesive RNA processing/translation regulatory module.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0010610","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0060211","count":3}]},{"hash":"1661417401572580606","title":"Embryonic morphogenesis and cell polarity","description":"The GO terms cluster around developmental processes such as gastrulation, mesoderm migration, and foregut morphogenesis, along with cell polarity cues (polarity establishment, apical constriction) and adhesion-related regulation (integrin activation, membrane localization). This suggests a cohesive theme of embryonic tissue morphogenesis and polarity rather than a single enzymatic function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":2},{"id":"GO:0032960","count":1},{"id":"GO:2000114","count":1},{"id":"GO:0090004","count":1},{"id":"GO:0033623","count":1}]},{"hash":"1545347345701991371","title":"Neuronal Adhesion and Axon Guidance","description":"The top terms cluster around nervous system development, neuron\u2013cell adhesion, and axon guidance (e.g., neuron cell-cell adhesion, dopaminergic neuron axon guidance, corticospinal tract morphogenesis). While a couple non-neural terms appear, the dominant signal is neuronal connectivity and development, supporting this label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007158","count":3},{"id":"GO:0086073","count":2},{"id":"GO:0021957","count":2},{"id":"GO:0003273","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1120416885946288036","title":"Vesicle trafficking and cytoskeleton regulation","description":"This cluster centers on processes tied to vesicle dynamics and cytoskeletal remodeling: actin polymerization regulation, exocytosis and exosome secretion control, and vesicle-targeting pathways (Cvt). While there are additional development- and differentiation-related terms (cochlea/kidney morphogenesis, macrophage differentiation), these likely reflect broader roles of vesicle trafficking in organogenesis and cell fate. Overall, the common thread appears to be vesicle transport coupled with cytoskeletal dynamics influencing secretion and organelle biogenesis.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035900","count":2},{"id":"GO:0090103","count":1},{"id":"GO:0030838","count":1},{"id":"GO:1903542","count":1},{"id":"GO:2000300","count":1}]},{"hash":"1410349491739263071","title":"Neural development, synaptic plasticity, and axon guidance","description":"The terms converge on neural development and neuronal signaling: synaptic plasticity, axon fasciculation, photoreceptor differentiation, and MAPK-regulated signaling, with supportive cues from cell adhesion/migration in neural contexts and broader developmental processes like axial mesoderm formation. This suggests a cluster centered on neural development and connectivity rather than unrelated pathways.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048170","count":2},{"id":"GO:0043408","count":2},{"id":"GO:1904237","count":2},{"id":"GO:0070106","count":2},{"id":"GO:0048320","count":2}]},{"hash":"782320277747663542","title":"Ubiquitination and Proteasomal Degradation","description":"The cluster is dominated by GO terms for ubiquitination, deubiquitination, sumoylation, neddylation, and SCF/APC-driven proteasomal catabolic processes, all pointing to regulation of protein stability via the ubiquitin-proteasome system and related post-translational modifications. While TNF signaling and DNA repair terms appear, the central theme is PTMs and targeted proteolysis that control protein turnover, hence the label. ","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0016925","count":3},{"id":"GO:0016579","count":3},{"id":"GO:0031145","count":2}]},{"hash":"2166353790959292158","title":"Ubiquitin-Proteasome\u2013Chromatin Regulation","description":"Top GO terms point to protein degradation and ubiquitination (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; free ubiquitin chain polymerization; proteasome localization) alongside chromatin/centromere-related processes (chromosome segregation; heterochromatin maintenance; histone phosphorylation regulation). This combination suggests a coherent theme where ubiquitin-proteasome activity regulates chromatin dynamics and cell-cycle progression. Some terms (BMP signaling, NF-kappaB regulation) are less central and may reflect broader signaling cross-links in the same proteins, but do not override the core proteostasis/chromatin signal.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:1990920","count":5},{"id":"GO:0033128","count":5},{"id":"GO:0007059","count":5},{"id":"GO:0010976","count":5},{"id":"GO:0030509","count":5}]},{"hash":"777562074458326712","title":"APC-Dependent Proteolysis","description":"This cluster shows a signal for ubiquitin-mediated proteolysis linked to the Anaphase-Promoting Complex (APC), notably the APC-dependent catabolic process and K11-linked ubiquitination terms. These terms strongly point to cell-cycle\u2013regulated degradation of substrates by ubiquitin, which ties the proteins together despite several noisy or unrelated terms present (e.g., dsRNA response, chlorophyll, or prostate-related terms). Overall, the most coherent theme is APC-driven proteolysis during mitosis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902325","count":2},{"id":"GO:0030850","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0043278","count":2}]},{"hash":"2021199515325949685","title":"Neural development and axon guidance","description":"Most terms cluster around nervous system development and axon pathfinding, e.g., nervous system development, axon guidance, Slit-Robo signaling, and Hedgehog/Smoothed pathway components. ERK cascade involvement and PI3K-related signaling also align with neuronal signaling and connectivity. A few terms (kidney development, cell division) are less related, but the dominant theme clearly points to neural development and guidance. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0070374","count":2}]},{"hash":"255568114201424015","title":"Synaptic Transmission and Plasticity","description":"Based on the top GO terms, the cluster is enriched for neuronal synaptic functions: regulation of synaptic vesicle exocytosis, neurotransmitter secretion, long-term potentiation, and calcium signaling, all central to synaptic transmission and plasticity. Additional terms for PI-mediated signaling and VEGF receptor signaling reflect broad signaling roles that can modulate neuronal activity. While a few terms (myoblast fusion, ABA signaling) are less clearly related, the dominant pattern points to neuronal signaling machinery, suggesting this cluster captures proteins involved in synaptic communication and plasticity.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007520","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0071277","count":2},{"id":"GO:0009738","count":2},{"id":"GO:0048015","count":2}]},{"hash":"1352622747661492372","title":"Ubiquitin-like conjugation and autophagy","description":"These proteins are enriched for ubiquitin-like modifier processes (sumoylation, urmylation, ufmylation) and autophagy-related pathways (macroautophagy, mitophagy, and Cvt-mediated cytoplasm-to-vacuole targeting), suggesting a shared role in post-translational modification and subsequent autophagic turnover. Some terms (cell cycle regulation, transcription modulation, certain biosynthetic cofactors) are less central, likely reflecting peripheral or broader roles. ","confidence":"Medium","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":4},{"id":"GO:0032447","count":3},{"id":"GO:0007113","count":3},{"id":"GO:0000422","count":3},{"id":"GO:0006777","count":3}]},{"hash":"2038978413888040693","title":"Signaling and Cytoskeleton Regulation","description":"This cluster centers on terms involving regulation of signaling pathways, particularly TORC1 and Rho/GTPase signaling, which relate to control of cytoskeletal dynamics and trafficking (e.g., intracellular transport and microvillus assembly). Transcription-related term appears but is less dominant; overall, the common theme is regulation of signaling that governs cytoskeletal organization and vesicle movement. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904263","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0043951","count":2}]},{"hash":"1861883047951955818","title":"Vesicle trafficking and exocytosis regulation","description":"The cluster\u2019s GO terms cluster around vesicle-related processes (synaptic vesicle priming, intracellular protein transport, acrosome reaction, neutrophil degranulation) and signaling regulators (Rho/Ras) that govern cytoskeletal dynamics and vesicle movement. The combination points to a shared function in regulating vesicle trafficking and exocytosis across diverse cell types, with some regulatory signaling involvement, making a vesicle-focused label appropriate.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0016082","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0046580","count":3}]},{"hash":"1432496054280306305","title":"RNA metabolism and xenobiotic response","description":"This cluster centers on nucleic acid metabolism and post-transcriptional regulation, including regulation of mRNA stability and RNA phosphodiester bond processing, with additional signals of stress/detox pathways such as response to xenobiotic stimulus and redox homeostasis. A phosphoinositide signaling term connects to membrane-based signaling that can modulate stress responses, reinforcing a general RNA- and detox-associated theme. The renal water transport term appears less integrative and may be an outlier. Overall, the set seems to reflect RNA processing together with cellular defense against xenobiotics, supporting this label.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:2001153","count":3},{"id":"GO:1903507","count":3},{"id":"GO:0046856","count":3},{"id":"GO:0043488","count":3},{"id":"GO:0045454","count":3}]},{"hash":"2223435887659827151","title":"Unknown","description":"There are no GO terms or functional signals to tie these proteins together, and with zero edges/triangles and no top terms, there is no clear shared function to label this cluster.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1821501092773657021","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0034415","count":1},{"id":"GO:0002107","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0000738","count":1}]},{"hash":"723530973167133368","title":"Neuronal signaling and triglyceride metabolism","description":"The top GO terms point to neuronal signaling (calcium ion transport across membranes, excitatory postsynaptic potentials, visual perception) alongside lipid metabolism (triglyceride catabolic/mobilization/remodeling, phosphatidylethanolamine catabolic processes). This suggests a cluster of proteins involved in both neural signaling processes and lipid remodeling in membranes, a plausible shared function in neural contexts.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070588","count":2},{"id":"GO:2001046","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0036153","count":2}]},{"hash":"1025954443243778195","title":"Cell Cycle and DNA Replication Regulation","description":"The top GO terms are dominated by mitotic spindle attachment to kinetochores, DNA replication, meiotic checkpoint signaling, and intra-S DNA damage checkpoint pathways, pointing to a core theme of cell cycle control and DNA synthesis. While a few terms (e.g., vascular branching, cardiac hypertrophy, cocaine response) appear, they are less central to the cluster's apparent primary function and may reflect broader annotations or multifunctional proteins. Overall, the cluster seems best characterized by regulation of cell cycle progression and DNA replication. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":2},{"id":"GO:0046086","count":2},{"id":"GO:0051315","count":2},{"id":"GO:1903244","count":2},{"id":"GO:0031573","count":2}]},{"hash":"24566440875434575","title":"Adaptive Immune Regulation and Antigen Presentation","description":"The terms cluster around adaptive immunity: regulation of NK/T cell activation, antigen processing and MHC II presentation, macrophage activation control, immune tolerance, and the adaptive immune response. The AV node term appears as an outlier, but the dominant signal is immune activation and tolerance regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071656","count":2},{"id":"GO:0060369","count":2},{"id":"GO:0051134","count":2},{"id":"GO:0086016","count":2},{"id":"GO:0002588","count":2}]},{"hash":"1027788402749583612","title":"RNA transcription and ribosome biogenesis","description":"This cluster is defined by GO terms spanning transcription by RNA polymerases I, II, and III (including tRNA transcription, RNA-templated transcription, elongation, and termination) together with ribosome biogenesis and tRNA modification, pointing to a nucleolar program linking transcriptional activity with ribosome assembly.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042797","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0006385","count":1},{"id":"GO:0006366","count":1}]},{"hash":"1856798280217649480","title":"General Catabolic Metabolism","description":"The top GO terms indicate a broad set of catabolic processes across diverse substrates (uracil, triglycerides, glucuronosides, prostaglandins, xenobiotics) and related metabolic pathways, rather than a single specific function. This suggests the cluster reflects general catabolic metabolism rather than a focused pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019380","count":2},{"id":"GO:0006212","count":2},{"id":"GO:0019740","count":2},{"id":"GO:1902348","count":2}]},{"hash":"1422661658263991935","title":"Steroid and lipid biosynthesis","description":"Based on the top GO terms, the proteins cluster around biosynthetic processes for lipids and steroid-derived compounds (sphingolipid biosynthesis, estrogen and glucocorticoid biosynthesis, 3-keto-sphinganine metabolism, and fatty acid elongation). There are also terms for retinoic acid and melanin biosynthesis, and even tropane alkaloid biosynthesis, suggesting a broader theme of diverse small-molecule biosynthesis rather than a single tightly defined pathway. Overall, the common link is enzymes involved in generating various bioactive metabolites through biosynthetic routes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030148","count":2},{"id":"GO:0006703","count":2},{"id":"GO:0006710","count":2},{"id":"GO:0042438","count":2},{"id":"GO:0006666","count":2}]},{"hash":"748004057604910384","title":"ER Stress Response","description":"Based on GO terms, several entries point to unfolded protein response and ER stress: response to unfolded protein, chaperone-dependent refolding, ERAD pathway, and regulation of translation initiation in response to ER stress, suggesting these proteins function in managing the protein folding load in the endoplasmic reticulum. While a few terms are unrelated (e.g., angiogenesis, neuron guidance), the dominant theme is ER stress/protein folding, so this label captures the cluster's central function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009736","count":3},{"id":"GO:0070389","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006986","count":2}]},{"hash":"60263207698873090","title":"Inflammation and ECM remodeling","description":"The GO terms point to immune/inflammatory processes (leukocyte migration, acute-phase response, defense against Gram-positive bacteria) along with tissue remodeling and extracellular matrix disassembly, plus regulation of fibrinogen and coagulation\u2014together suggesting inflammation-linked remodeling of the extracellular matrix. Some terms (ANP-regulated blood pressure, glucose response) are less central but do not override the core inflammatory/remodeling signal. Overall, a coherent theme is inflammatory response coupled with ECM remodeling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003050","count":2},{"id":"GO:0045079","count":2},{"id":"GO:0002523","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0071333","count":2}]},{"hash":"1831244150945517522","title":"DNA replication and cell cycle regulation","description":"The strongest signals are DNA replication and mitotic control (DNA replication; spindle/kinetochore attachment; intra-S DNA damage checkpoint; meiotic recombination checkpoint), which together point to a cell-cycle\u2013related cluster. The other GO terms (calcineurin-NFAT signaling, adenosine biosynthetic process, branching in blood vessel morphogenesis, response to cocaine, endocytic recycling, cardiac hypertrophy) are less coherent with this theme and may reflect multifunctional proteins or annotation noise, so the core theme remains DNA replication and cell cycle regulation.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0051531","count":1},{"id":"GO:0046086","count":1},{"id":"GO:0051315","count":1},{"id":"GO:1903244","count":1}]},{"hash":"2080174132405487659","title":"Calcium-dependent signaling in muscle development","description":"The top GO terms cluster around calcium signaling (calcineurin-NFAT cascade, calcium-modulating Wnt pathway), phosphorylation regulation, and muscle-related processes (myoblast fusion, cardiac hypertrophy), with supporting hints of hypoxia response and vascular remodeling. This suggests a group of proteins coordinating calcium-dependent signaling to drive muscle development and associated tissue remodeling under stress, hence the label.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":1},{"id":"GO:0006607","count":1},{"id":"GO:0010800","count":1},{"id":"GO:1903244","count":1},{"id":"GO:0006469","count":1}]},{"hash":"1047434309235462595","title":"Vertebrate craniofacial and neural development","description":"The GO terms cluster around craniofacial morphogenesis (roof of mouth development, cartilage development) and neural development (neuron differentiation, midbrain-hindbrain boundary development, neurohypophysis development, retrotrapezoid nucleus), with supporting terms for cochlea morphogenesis and epithelial maturation. This pattern suggests proteins involved in vertebrate embryonic development of facial/cranial structures and neural tissues, with some related lipid biosynthesis processes. ","confidence":"High","size":5,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0021526","count":2},{"id":"GO:0002070","count":2},{"id":"GO:0030917","count":2},{"id":"GO:0021985","count":2}]},{"hash":"2091536738254698382","title":"NF-kB/TNF inflammatory signaling regulation","description":"The top GO terms cluster around regulation and activation of inflammatory signaling pathways: positive regulation of TNF-mediated signaling, positive regulation of non-canonical NF-kappaB signaling, and regulation of the JNK cascade, along with chemokine production. There are also immune-related processes such as host antiviral defense and regulation of nitric-oxide synthase, and autoubiquitination as a modulation mechanism. Together these terms suggest proteins modulate immune/inflammatory signaling, particularly NF-kB and TNF pathways, rather than a single enzymatic function. Therefore the label NF-kB/TNF inflammatory signaling regulation captures the cluster's shared theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":2},{"id":"GO:1903762","count":2},{"id":"GO:0051865","count":2},{"id":"GO:1901536","count":2},{"id":"GO:1901224","count":2}]},{"hash":"1793394314000535188","title":"Unknown","description":"The GO terms listed are highly diverse, including cardiac apoptosis, hypoxia response, rRNA maturation, TGF-beta response, histone acetylation, neural tube closure, and translation initiation. This mix does not converge on a single coherent function or pathway for the cluster, suggesting no clear shared theme. Therefore, Unknown with no confidence in a representative function.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0010659","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0043966","count":3}]},{"hash":"1034783970112667681","title":"Neural development and secretory trafficking","description":"This cluster's top GO terms cluster around brain development (forebrain development) and cell proliferation, with additional terms for ER-to-Golgi transport and COPII vesicle budding, implying a link between neural development and secretory pathway activity. The combination of developmental and trafficking processes supports a neural-development functional theme, albeit with some general proliferation signals.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":4},{"id":"GO:0071560","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0008283","count":3}]},{"hash":"1562059171232634233","title":"Calcium signaling and membrane dynamics","description":"The terms cluster around signaling and membrane/cytoskeletal processes: calcium import across the plasma membrane, membrane depolarization during cardiac action potential, endocytosis/pinocytosis regulation, kinase activity regulation, and cell migration. These point to membrane-associated signaling and cellular movement as the shared theme. A couple of terms (follicular dendritic cell differentiation and telomere-related processes) seem tangential, likely reflecting multi-function proteins or annotation breadth. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002268","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0071901","count":4},{"id":"GO:0098703","count":4},{"id":"GO:0048549","count":4}]},{"hash":"100875743342196888","title":"Synapse organization and neuronal adhesion","description":"The top GO terms point to synaptic vesicle clustering, protein localization to synapse, and neuron cell\u2013cell adhesion, indicating a cluster tied to neuronal synapse assembly and connectivity; a few terms appear unrelated (stress response, morphogenesis) and may reflect annotation noise.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000809","count":2},{"id":"GO:1902474","count":2},{"id":"GO:0007158","count":2},{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2}]},{"hash":"808092265774791262","title":"Unknown","description":"The GO terms cover immune signaling, RNA processing, fertilization, cell division, and mitochondrial import with no clear single function tying them together, so a cohesive label cannot be confidently assigned.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048291","count":4},{"id":"GO:0090666","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0002931","count":4}]},{"hash":"1521295881695550221","title":"Axonogenesis and ECM Remodeling","description":"The cluster highlights neuronal growth and axon formation (axonogenesis, axon regeneration, regulation of establishment of cell polarity) alongside extracellular matrix remodeling and adhesion signaling (integrin-mediated signaling, positive regulation of metallopeptidase activity, hyaluronan metabolic process). This combination points to a cohesive module where cell-ECM interactions drive neurite outgrowth and axonal development, with additional signaling tied to inflammatory and metabolic cues (prostaglandin response, glucose stimulus) that can influence neuronal growth. Confidence: High","confidence":"","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007229","count":4},{"id":"GO:1905050","count":4},{"id":"GO:0030212","count":4},{"id":"GO:0097194","count":3},{"id":"GO:0010954","count":3}]},{"hash":"1455031878073322136","title":"Calcium-Dependent Signaling in Development","description":"The terms cluster around calcium-regulated pathways (calcineurin-NFAT, Ca2+-modulated Wnt), kinase activity regulation, and developmental processes across tissues (vasculature, photoreceptors, cuticle). This suggests a theme of calcium-dependent signal transduction guiding development and stress responses, despite some broader associations like hypoxia or hypertrophy. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0010800","count":2},{"id":"GO:1903244","count":2},{"id":"GO:0006469","count":2}]},{"hash":"1152239378261395041","title":"Development and Stress-Response Signaling","description":"The proteins in this cluster are enriched for developmental processes (thymus and placenta development) and for cellular stress and signaling responses (cadmium ion response, prostaglandin E response, glucose response, apoptosis execution, and regulation of cell polarity/axon regeneration), indicating a theme of development intertwined with stress- and signaling-related pathways rather than a single narrow function.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048538","count":4},{"id":"GO:0001890","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0000187","count":4},{"id":"GO:0097194","count":3}]},{"hash":"1417345328801430654","title":"Dopaminergic Signaling and Sensory Perception","description":"The top GO terms cluster around neural signaling and sensory processing: dopaminergic synaptic transmission, sensory perception (pain and vision), behavioral response to cocaine, and neuronal ERK signaling. While a few terms touch cardiovascular development or blood pressure regulation, the dominant theme is neuronal communication and sensory modalities, suggesting the proteins function mainly in neurotransmission and perception pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0048148","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0007507","count":4}]},{"hash":"1578441159177543286","title":"NF-kB/NFAT signaling and transcription regulation","description":"This cluster is dominated by terms related to NF-kappaB signaling and NFAT pathway regulation, plus transcriptional control (DNA binding, DNA-templated transcription) and protein ubiquitination \u2014 all characteristic of immune signaling and gene regulation. Unfolded protein response and corticosterone response suggest stress integration. Overall, label reflects immune signaling with transcriptional regulation via NF-kB/NFAT.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051412","count":2},{"id":"GO:0035774","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0006986","count":2},{"id":"GO:0043388","count":2}]},{"hash":"1175236474326700097","title":"Cilium and Visual Perception","description":"The Top Terms center on cilium assembly, visual perception, receptor recycling, and sensory neuron axon guidance, suggesting the proteins cluster around ciliary/sensory cell function and trafficking relevant to photoreception. Other terms like tRNA modification, cell division, GTPase regulation, and kinetochore localization are less coherent with this theme, so the strongest interpretation is a cilium- and vision-related cluster with some noise from broader annotations.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905490","count":2},{"id":"GO:0035330","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0001881","count":2},{"id":"GO:0060271","count":2}]},{"hash":"1446262481437473998","title":"Mitotic spindle assembly and microtubule polarity","description":"Most of the top GO terms describe mitotic processes and microtubule/cytoskeleton organization (mitotic metaphase chromosome alignment; initial spindle pole body separation; spindle midzone assembly; establishment or maintenance of microtubule cytoskeleton polarity; and meiotic spindle orientation). A few terms point to cytoskeleton-related cellular functions such as actomyosin contractile ring assembly, which supports cytokinesis. Additional, less central terms touch on dendritic transport and stem cell homeostasis, suggesting a broader theme of cytoskeletal dynamics and cell organization rather than a single pathway.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007080","count":1},{"id":"GO:0098971","count":1},{"id":"GO:0000073","count":1},{"id":"GO:0000915","count":1},{"id":"GO:0030951","count":1}]},{"hash":"711703482929533902","title":"Neural development and axon guidance","description":"The top GO terms center on neural processes: long-term neuronal synaptic plasticity, fasciculation of sensory neuron axons, and photoreceptor differentiation, indicating neural development and connectivity. Additional terms about MAPK signaling regulation and cell-matrix adhesion suggest coordinated signaling and adhesion during neuronal development and axon pathfinding. While some terms touch broader development, the strongest theme is neural development and axon guidance.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048170","count":4},{"id":"GO:0043408","count":4},{"id":"GO:1904237","count":4},{"id":"GO:0070106","count":4},{"id":"GO:0048320","count":4}]},{"hash":"1702744944496923584","title":"Plant meristem and photosystem regulation","description":"The topGO terms include positive regulation of meristem identity and photosystem stoichiometry adjustment, pointing to plant development and chloroplast/ photosystem regulation as the core theme. Additional terms cover broader signaling regulation, but the clearest, most coherent signals are plant-specific developmental and photosynthetic processes, justifying a label focused on these aspects. Confidence: Medium","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046827","count":3},{"id":"GO:0061191","count":3},{"id":"GO:0010074","count":3},{"id":"GO:0080005","count":3},{"id":"GO:0042347","count":3}]},{"hash":"135783363694973262","title":"Neuronal development and apoptosis regulation","description":"The set of terms highlights axonogenesis, axon regeneration, and neuronal development, together with regulation of apoptosis and cell survival, indicating a cluster tied to neural development and cell fate decisions rather than general metabolism.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097194","count":3},{"id":"GO:0010954","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0048679","count":3},{"id":"GO:0071380","count":3}]},{"hash":"2299972877788604666","title":"Axonogenesis and Apoptosis Regulation","description":"Top terms point to neuronal development and cell fate control, with axonogenesis and regulation of axon regeneration alongside apoptosis-related terms (execution phase of apoptosis, positive regulation of programmed cell death). Additional terms on cell polarity and stimulus responses (prostaglandin E, glucose) support a cohesive theme around neuronal growth and survival signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097194","count":1},{"id":"GO:0010954","count":1},{"id":"GO:0071333","count":1},{"id":"GO:0048679","count":1},{"id":"GO:0071380","count":1}]},{"hash":"661307748178461546","title":"Mitochondrial protein import and respiration","description":"The top GO terms are dominated by mitochondrial processes: insertion of proteins into the mitochondrial inner membrane, assembly of respiratory chain complex III, and positive regulation of oxidative phosphorylation, along with protein folding/processing and autophagosome maturation. These point to a cohesive mitochondrial maintenance module focused on protein import/assembly and energy production, with mitophagy as a quality-control layer. DNA replication terms appear ancillary.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006270","count":2},{"id":"GO:0034551","count":1},{"id":"GO:1903862","count":1},{"id":"GO:0043335","count":1},{"id":"GO:0032979","count":1}]},{"hash":"1990273493270517531","title":"Mitotic spindle and cytoskeleton dynamics","description":"Most terms point to microtubule-based processes and mitosis: metaphase chromosome alignment, spindle pole separation, spindle midzone assembly, maintenance of microtubule cytoskeleton polarity, and actomyosin contractile ring assembly for cytokinesis. These collectively indicate coordinated spindle function and cytoskeletal remodeling during cell division. Some other terms (neuronal dendritic transport, morphine response, epidermal stem cell homeostasis, stress granule disassembly, integrin regulation) are less central and likely peripheral to the core theme. Overall, the dominant signal is cytoskeletal dynamics guiding mitosis.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":2},{"id":"GO:0007080","count":1},{"id":"GO:0098971","count":1},{"id":"GO:0000073","count":1},{"id":"GO:0000915","count":1}]},{"hash":"1352362907222962161","title":"Nuclear transport and protein oligomerization","description":"The cluster is dominated by GO terms for nuclear transport (mRNA/tRNA export, regulation of nuclear import, mitotic nuclear membrane disassembly) and protein\u2013protein interaction/assembly (homooligomerization, heterotrimerization), with a few peripheral terms that are less central to the main theme.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0006409","count":2},{"id":"GO:0042306","count":2},{"id":"GO:0070208","count":2}]},{"hash":"171776597741872632","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000463","count":4},{"id":"GO:0000467","count":4},{"id":"GO:0006268","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0070870","count":4}]},{"hash":"431981208641319270","title":"GPCR Signaling in Cardiovascular and Immune Regulation","description":"The top GO terms point to GPCR signaling and its regulation, with strong cardiovascular links (blood pressure regulation, vascular smooth muscle differentiation) and immune/inflammatory connections (IL-1\u03b2 production, prostaglandin response). That combination suggests a cohesive functional theme around GPCR-mediated signaling coordinating cardiovascular and immune processes, despite a few outliers like midgut development. Overall, the cluster appears to reflect GPCR-driven regulatory pathways across these systems.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001991","count":3},{"id":"GO:0007195","count":3},{"id":"GO:0060408","count":3},{"id":"GO:0007497","count":3},{"id":"GO:0006955","count":3}]},{"hash":"2267934510473226203","title":"Blood Pressure GPCR Signaling","description":"The top GO terms cluster around positive regulation of blood pressure and GPCR signaling that activates adenylyl cyclase, suggesting these proteins participate in vascular signaling and blood pressure control, including renin-angiotensin and dopamine/acetylcholine pathways. The presence of an electron transport chain term may reflect broader cellular energy context, but the dominant theme is GPCR-mediated regulation of vascular tone.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":4},{"id":"GO:0010579","count":4},{"id":"GO:0022900","count":4},{"id":"GO:0007190","count":4},{"id":"GO:0001991","count":2}]},{"hash":"929635942446285647","title":"Cardiovascular GPCR Signaling and Blood Pressure","description":"Top terms show cardiovascular signaling and blood pressure regulation via GPCR pathways (dopamine, acetylcholine, prostaglandin, renin-angiotensin). There is also some energy metabolism and immune signaling, but the dominant theme is GPCR-driven control of vascular tone.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":4},{"id":"GO:0010579","count":4},{"id":"GO:0022900","count":4},{"id":"GO:0035025","count":4},{"id":"GO:0001991","count":3}]},{"hash":"1166393027625642970","title":"Embryonic neural and craniofacial morphogenesis","description":"The GO terms cluster around developmental processes in the embryo, especially brain development (forebrain, midbrain-hindbrain boundary), craniofacial/skeletal formation (cranial skeleton morphogenesis, cartilage development), and sensory/organ morphogenesis (cochlea, nephron patterning, neurohypophysis), indicating a cohesive theme of early morphogenesis across neural and craniofacial structures.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":2},{"id":"GO:0060441","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0021526","count":1},{"id":"GO:0002070","count":1}]},{"hash":"679781759908980842","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015012","count":2},{"id":"GO:0030210","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0045047","count":1}]},{"hash":"408680056593083001","title":"Unknown","description":"The GO terms span immune differentiation, cell migration, ion transport, endocytosis, and telomere regulation, with no common function linking the four proteins. Because there are no edges and no cohesive theme, a meaningful label cannot be determined.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002268","count":1},{"id":"GO:0016477","count":1},{"id":"GO:0071901","count":1},{"id":"GO:0098703","count":1},{"id":"GO:0048549","count":1}]},{"hash":"1453376545466927224","title":"Axon guidance and neural development","description":"The top GO terms cluster around neural signaling and axon pathfinding (axon guidance, Roundabout signaling pathway, nervous system development), with supporting pathways like smoothened signaling and ERK cascade regulation. Some terms also touch on organ morphogenesis (cochlea morphogenesis, kidney development), but the dominant theme is neural development and axon guidance.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0007224","count":2}]},{"hash":"1853335878739409421","title":"Diverse Metabolic Processes","description":"The GO terms encompass several metabolic pathways (nitrogen/sulfur nutrition, lipid/sterol metabolism, and chlorophyll-related processes) across different organisms, with no single cohesive function uniting all terms. This suggests a cluster of proteins involved in varied metabolic activities rather than a specific shared function.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":1},{"id":"GO:0000001","count":1},{"id":"GO:0015994","count":1},{"id":"GO:0032286","count":1},{"id":"GO:0001949","count":1}]},{"hash":"70222567481073850","title":"Steroid Hormone Biosynthesis and Retinoic Acid Metabolism","description":"The top GO terms are dominated by biosynthetic processes for steroid hormones (progesterone, cortisol, aldosterone) and 9-cis-retinoic acid, with additional related P450 epoxygenase pathways, suggesting a cohesive theme of hormone/retinoid metabolism driven by cytochrome P450 enzymes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":3},{"id":"GO:0019383","count":2},{"id":"GO:2001037","count":2},{"id":"GO:0042904","count":2},{"id":"GO:0032342","count":2}]},{"hash":"84917836328710476","title":"Cytoskeletal dynamics and morphogenesis","description":"The terms cluster around cytoskeletal organization and remodeling (actomyosin contractile ring, microtubule localization, terminal web) and developmental/morphogenetic processes (karyogamy, ascospore formation, proboscis morphogenesis). While a couple of terms relate to unrelated processes, the dominant theme appears to be cytoskeleton-driven division and morphogenesis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":2},{"id":"GO:0030437","count":2},{"id":"GO:1902896","count":2},{"id":"GO:1903475","count":1},{"id":"GO:0048734","count":1}]},{"hash":"1597855631519926755","title":"Unknown","description":"The top terms are highly diverse (actin nucleation regulation, cardiac apoptosis, hypoxia response, rRNA maturation, TGF-beta signaling, histone acetylation, neural tube closure, translation initiation). There is no single shared biological process linking all four proteins, suggesting the cluster spans multiple unrelated pathways. Therefore, Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034316","count":3},{"id":"GO:0010659","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0071560","count":2}]},{"hash":"1624616635014034790","title":"Ubiquitin-regulated TNF/NF-\u03baB/JNK signaling","description":"The terms point to a coherent theme of ubiquitin-mediated regulation\u2014protein ubiquitination and degradation\u2014alongside key immune signaling pathways (TNF signaling, I\u03baB/NF-\u03baB phosphorylation, JNK cascade) and processes like apoptosis and adaptive immunity, suggesting these proteins modulate immune response and signaling via ubiquitin tagging. An outlier term related to X-chromosome dosage compensation appears incidental.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":3},{"id":"GO:1903762","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0042787","count":3}]},{"hash":"783362667311687422","title":"Translation Initiation Complex Assembly","description":"The GO terms are dominated by translation initiation processes: formation of cytoplasmic translation initiation complex, formation of translation preinitiation complex, and regulation of translational initiation, suggesting the proteins in this cluster participate in assembling and controlling the translation initiation machinery. Some terms also touch development and cell-cycle processes, but the core signal relates to translation initiation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001732","count":1},{"id":"GO:0008283","count":1},{"id":"GO:0006446","count":1},{"id":"GO:0001701","count":1},{"id":"GO:0035914","count":1}]},{"hash":"2297736499605492687","title":"Ubiquitin-Dependent Apoptosis and Signaling","description":"The top GO terms center on ubiquitin-dependent protein catabolic processes and autoubiquitination, alongside regulation of apoptotic processes, JNK signaling, and TNF-mediated pathways, with an additional note of adaptive immune response. This combination suggests a functional cluster of proteins involved in ubiquitin-mediated regulation of protein degradation, cell death, and immune signaling, likely comprising ubiquitin ligases or related regulators. Given the limited edges but coherent GO themes, the label captures the core function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:1903265","count":2},{"id":"GO:1903762","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0046328","count":2}]},{"hash":"1109724117164779469","title":"Large subunit ribosome biogenesis and export","description":"Top GO terms strongly point to assembly, maturation, and nuclear export of the large ribosomal subunit (LSU), including LSU subunit precursor assembly and maturation of LSU rRNA. Although a few terms touch other processes, the dominant theme is LSU biogenesis, suggesting proteins function together in assembling and exporting the large ribosome. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:1902626","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0000466","count":1}]},{"hash":"1970370501301253039","title":"Cell adhesion and ECM remodeling","description":"This cluster is enriched for cell adhesion and extracellular matrix-related terms, including calcium-independent cell-matrix adhesion, heterotypic cell-cell adhesion, and negative regulation of ECM assembly, with blood coagulation linking to matrix biology. Additional terms like proteasome assembly and ubiquitin-dependent protein catabolic process, T cell activation, and dendrite regeneration suggest broader cellular roles, but the strongest recurring theme is adhesion to and remodeling of the extracellular matrix.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0031104","count":3},{"id":"GO:0006511","count":2},{"id":"GO:0002291","count":2}]},{"hash":"1413324758682684468","title":"Stress-Responsive Signaling and Transcription Regulation","description":"The proteins cluster around regulatory processes: regulation of signaling cascades (e.g., calcineurin-NFAT), regulation of kinase activity, nuclear import, and transcriptional activation, all within contexts of stress responses such as hypoxia and hypertrophic signaling. While some GO terms (e.g., development-related ones) are broader or organism-specific, the dominant theme is modulation of signaling and transcription in response to stress. Confidence: Medium","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051531","count":3},{"id":"GO:0006607","count":3},{"id":"GO:1903244","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0071456","count":3}]},{"hash":"2062640570459490182","title":"Neural and Cardiac Development","description":"The top GO terms cluster around nervous system development and neural processes (nervous system development, corticospinal tract morphogenesis, dopaminergic neuron axon guidance, sensory perception of sound) alongside heart development/conduction-related terms (endocardial cushion formation, bundle of His/Purkinje myocyte adhesion). This suggests a common theme of vertebrate development in neural and cardiac tissues, with supporting signaling and adhesion modulation (integrin activation, synaptic vesicle clustering). Some outliers exist (immune and plant-related terms), but the dominant pattern supports a neural-and-cardiac developmental theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086073","count":2},{"id":"GO:0021957","count":2},{"id":"GO:0003273","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1050676803137736943","title":"Endothelial development and vascular signaling","description":"Dominant terms point to vascular biology, with regulation of vascular permeability, endothelial tube lumen extension, and in utero embryonic development, along with calcineurin-NFAT signaling that can influence vascular/cardiac development. Other terms reflect general trafficking and growth signaling that may accompany multiple tissues but are less central here. Overall, the core theme aligns with endothelial development and vascular signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":1},{"id":"GO:0043114","count":1},{"id":"GO:0051683","count":1},{"id":"GO:0001701","count":1},{"id":"GO:0032402","count":1}]},{"hash":"1464334804250096289","title":"BMP and WNT developmental signaling","description":"The top GO terms cluster around developmental signaling pathways, notably BMP signaling and canonical Wnt signaling, along with associated processes like neural crest differentiation and mammary gland development. While there are a couple lipid metabolism terms present, the strongest themes center on developmental signaling and differentiation, with regulation of serine/threonine phosphorylation supporting signaling modulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008203","count":2},{"id":"GO:0070328","count":2},{"id":"GO:0010800","count":2},{"id":"GO:0060749","count":2},{"id":"GO:0071901","count":2}]},{"hash":"2280758466964078834","title":"Muscle contraction regulation and fiber-type switching","description":"The top GO terms cluster around regulation of striated and slow/fast muscle contraction, muscle filament sliding, and transitions between fast and slow muscle fibers, with related ATP-dependent activity regulation and muscle development cues, indicating a coherent theme of muscle contraction control and fiber identity.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055010","count":2},{"id":"GO:0006942","count":2},{"id":"GO:0032972","count":2},{"id":"GO:0043057","count":2},{"id":"GO:0030049","count":2}]},{"hash":"1416492761984302350","title":"Unknown","description":"The GO terms span bone formation, synaptic vesicle clustering, endosomal transport, insulin-response, immune and biotic-response processes, and neuromuscular control, with no clear unifying function across the four proteins; thus a cohesive cluster label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030282","count":1},{"id":"GO:0097091","count":1},{"id":"GO:0060349","count":1},{"id":"GO:0099638","count":1},{"id":"GO:0044381","count":1}]},{"hash":"169364385336401396","title":"Protein Translation","description":"Based on the top GO term, translation (GO:0006412), the proteins in this cluster are associated with protein synthesis, suggesting membership in the translation machinery or factors involved in translation. The lack of additional terms or interactions does not contradict this interpretation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1}]},{"hash":"2079972121680023721","title":"Neural development and axon guidance","description":"These proteins cluster around neural development signals, with multiple terms for forebrain development, retinal ganglion and motor neuron axon guidance, and neuron migration, suggesting a role in neural patterning and axon pathfinding (with supportive cell adhesion and glial differentiation terms). Confidence reflects a coherent neural development theme despite a few non-neural terms.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0097477","count":3},{"id":"GO:0010001","count":3}]},{"hash":"2206781709516039352","title":"Protein degradation and autophagy regulation","description":"The GO terms cluster around post-translational modification and protein turnover: proteasomal catabolic regulation, autoubiquitination, sumoylation, and autophagosome maturation control, with translation and vesicle formation terms. This points to a group of proteins involved in protein quality control and degradation pathways; several other terms may reflect secondary or contextual roles.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045648","count":3},{"id":"GO:1901799","count":2},{"id":"GO:1903265","count":2},{"id":"GO:0021888","count":2},{"id":"GO:0051865","count":2}]},{"hash":"241710053074307356","title":"Insect chemosensory signaling and reproductive behavior","description":"This cluster\u2019s GO terms converge on behavioral regulation (egg-laying, female receptivity, larval locomotion, behavioral defense) and chemosensory detection (bitter taste), with accompanying membrane-targeting processes (protein targeting/insertion into membrane). Together, they suggest a small set of membrane-associated signaling components that modulate insect behavior through chemosensory inputs, rather than a metabolic or structural protein group. Confidence: Medium","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045434","count":1},{"id":"GO:1901045","count":1},{"id":"GO:0002209","count":1},{"id":"GO:0048042","count":1},{"id":"GO:0008345","count":1}]},{"hash":"741337313638392224","title":"Neuronal development and signaling","description":"The strongest signals are dendritic spine development, learning, bipolar cell growth, and EGFR pathway, which collectively point to neuronal growth, synaptic development, and signaling. Other terms like cilium localization and lysosomal organization appear as supporting cellular processes, but the prevalent neuronal-related terms dominate the cluster\u2019s function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0060999","count":2},{"id":"GO:0007612","count":2},{"id":"GO:0097499","count":2},{"id":"GO:0046909","count":2}]},{"hash":"2045126680065658654","title":"Membrane trafficking and synaptic vesicle regulation","description":"This small cluster centers on intracellular transport and membrane-associated processes: intracellular protein transport, localization to cortical microtubule cytoskeleton, regulation of synaptic vesicle exocytosis, plasma membrane repair, phosphatidylinositol metabolism, and myoblast fusion. Together these terms suggest a common theme of coordinating membrane dynamics with cytoskeletal docking and vesicle trafficking, possibly in neural or muscular contexts. Other terms about ribosomal export or transcription regulation are less cohesive with the main theme but may reflect broader cellular transport roles; the core signal points to vesicle/membrane trafficking and cytoskeletal regulation.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045943","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0048174","count":2},{"id":"GO:2000203","count":2}]},{"hash":"762500321405361034","title":"Proteasome-ubiquitin-driven protein degradation","description":"The cluster centers on ubiquitin-proteasome pathway activities, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, free ubiquitin chain polymerization, and proteasome-related processes linked to chromosome segregation. While a few terms (BMP signaling, neuron projection development) are less connected, the dominant signal is protein turnover via ubiquitination and proteolysis, suggesting a role in regulated protein degradation during cell cycle and chromatin-associated processes.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:1990920","count":4},{"id":"GO:0033128","count":4},{"id":"GO:0007059","count":4},{"id":"GO:0010976","count":4},{"id":"GO:0030509","count":4}]},{"hash":"849496729567207290","title":"Intracellular vesicle trafficking","description":"The proteins show strong GO signals for ER-to-Golgi vesicle transport, retrograde Golgi-ER transport, endocytosis, and targeting to the vacuole, indicating a cohesive role in intracellular vesicle trafficking; a few peripheral terms suggest broader regulatory roles but do not override the main theme.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0006623","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0090103","count":1}]},{"hash":"1366458283165211778","title":"Unknown","description":"The proteins are annotated with a wide mix of terms including proteasome-mediated protein degradation, autophagy regulation, TNF signaling, mitochondrial membrane permeability, neurodevelopment, erythrocyte differentiation, and responses to insecticide, with no obvious common pathway or function tying them together. Because of this lack of cohesion, a single interpretable cluster name is not supported.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901799","count":1},{"id":"GO:1903265","count":1},{"id":"GO:0046902","count":1},{"id":"GO:0021888","count":1},{"id":"GO:0051865","count":1}]},{"hash":"827057153697912956","title":"Immune Signaling and Inflammation","description":"Top GO terms cluster around innate and adaptive immune signaling (Toll signaling, TNF signaling, T cell receptor signaling) and inflammatory responses (response to lipopolysaccharide). Some terms relate to regulation of signaling by ubiquitination and receptor trimerization, supporting activation and modulation of immune pathways. A few terms touch on development or transcription regulation, but the strongest signal is immune activation, so the label is representative.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":1},{"id":"GO:0008063","count":1},{"id":"GO:0045672","count":1},{"id":"GO:0051865","count":1},{"id":"GO:0097300","count":1}]},{"hash":"658647113407565074","title":"Erythrocyte Maturation, Oxygen Transport, and Hemostasis","description":"The top GO terms cluster around red blood cell development (erythrocyte maturation, enucleation), together with oxygen transport and hemostasis (blood coagulation, platelet aggregation) and a hypoxia response, pointing to a cohesive theme of erythropoiesis and blood clotting. Peripheral terms like receptor-mediated endocytosis and collagen regulation are less central but do not overturn the overall blood physiology theme. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043249","count":2},{"id":"GO:0043353","count":2},{"id":"GO:0015671","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0032966","count":2}]},{"hash":"1969801511808991237","title":"Light sensing and phototransduction","description":"This cluster is dominated by GO terms for light detection in visual perception, GPCR opsin signaling, and cGMP biosynthesis, all hallmarks of photoreceptor light sensing and downstream phototransduction. The presence of positive phototaxis and neuronal action potential modulation further supports a role in light-driven signaling and response. Some terms (like CO2 detection) seem peripheral but do not override the main photoreception theme.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050908","count":2},{"id":"GO:0016056","count":2},{"id":"GO:0006182","count":2},{"id":"GO:1904640","count":2},{"id":"GO:0003031","count":2}]},{"hash":"15243612357240351","title":"Unknown","description":"No GO terms or connections are provided for this cluster (edges and triangles are zero), so there is no discernible shared function to name; without a common functional signal, the appropriate label is Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1259016670933908787","title":"Membrane trafficking and vesicle exocytosis","description":"The top GO terms point to intracellular protein transport, regulation of synaptic vesicle exocytosis, localization to cortical microtubule cytoskeleton, phosphatidylinositol metabolism, membrane repair, and fusion-related processes. Together they suggest a coherent theme of vesicle trafficking, membrane remodeling, and cytoskeleton\u2013membrane interactions, with exocytosis and membrane fusion as central elements.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045943","count":1},{"id":"GO:0010796","count":1},{"id":"GO:0006886","count":1},{"id":"GO:0048174","count":1},{"id":"GO:2000203","count":1}]},{"hash":"1554040101282813537","title":"Nervous system development and axon guidance","description":"The proteins are mainly annotated with neural development terms: axon guidance, nervous system development, Roundabout signaling, and related ERK cascade activity, suggesting a core theme around neural pathfinding and signaling. While there are also terms related to immune function and development in other tissues, they are fewer and do not override the neural pattern. Therefore the label reflects the dominant functional theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0002551","count":2},{"id":"GO:0007286","count":2}]},{"hash":"1831304955441303448","title":"Unknown","description":"There are no GO terms, edges, or other functional signals linking the proteins, so no coherent theme emerges to assign a specific label. Without observable function signals, the cluster is best described as Unknown with no confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"340827396275926012","title":"Regulation of transcription, translation, and degradation","description":"The GO terms indicate regulation of transcription by RNA polymerase II, regulation of translation initiation, and proteasomal degradation, together with related cell cycle and development terms, suggesting a cluster focused on gene expression control and protein turnover.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0045727","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000278","count":2}]},{"hash":"622713153852231615","title":"Unknown","description":"The GO terms span diverse processes across different biological contexts (DNA recombination, neural and gland development, photoreceptor organization, protein ubiquitination and cell cycle, chlorophyll, and histone modification) with no unifying function. This lack of a coherent shared theme makes a specific, representative label inappropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0021756","count":2},{"id":"GO:0035845","count":2},{"id":"GO:0070206","count":2},{"id":"GO:0030850","count":2}]},{"hash":"1308027011632997346","title":"Chromatin Organization and Nucleosome Assembly","description":"This cluster is dominated by chromatin-related processes: nucleosome assembly, heterochromatin organization, and localization to chromatin, along with histone modification terms (even some historical/obsolete annotations). These collectively point to proteins involved in packaging DNA and regulating chromatin state. A small number of viral-related terms appear, likely noise, but do not define the cluster\u2019s core function.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0097298","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0080182","count":2}]},{"hash":"945698672494662232","title":"Spliceosome Machinery and Cell Cycle","description":"The top GO terms point to core spliceosome functions (mRNA splicing via spliceosome, spliceosomal snRNP assembly), with a single cell cycle term suggesting a link to cell division. The obsolete androgen receptor term is not informative. Overall, these proteins are best described as spliceosome components with possible cell-cycle association.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0000387","count":1},{"id":"GO:2000825","count":1}]},{"hash":"1539383982990529588","title":"Neuronal Axon Guidance with ECM Remodeling","description":"The cluster is dominated by neural development and axon guidance terms (anterior/posterior, dopaminergic axon guidance, regulation of cell migration) plus ECM-related processes (basement membrane assembly, ECM disassembly, cell spreading, epithelial morphogenesis). Together, these indicate a group involved in neuronal pathfinding within ECM-rich environments, with signaling coupling via acetylcholine receptor pathways.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033564","count":2},{"id":"GO:0030334","count":2},{"id":"GO:0036514","count":2},{"id":"GO:0070831","count":2},{"id":"GO:0034446","count":2}]},{"hash":"391088175377018061","title":"Auditory Neuron Signaling and Ear Development","description":"The top GO terms cluster around neural signaling in the auditory pathway\u2014sensory perception of sound, glycinergic synaptic transmission, vestibulocochlear nerve development, acetylcholine receptor signaling, and membrane depolarization\u2014along with related dopaminergic regulation. This suggests a coherent theme of auditory neural activity and ear development, with some ancillary neuroendocrine aspects. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0060112","count":2},{"id":"GO:0060012","count":2},{"id":"GO:0021562","count":2},{"id":"GO:0043524","count":2}]},{"hash":"1729131663789766860","title":"Metanephric/mesonephric development and lymphangiogenesis","description":"Based on the dominant GO terms, the proteins cluster around developmental processes in the kidney (metanephric and mesonephric duct/tubule development) and lymphatic vessel formation, suggesting a shared role in organ morphogenesis with an emphasis on renal structures and concurrent lymphatic development. While some immune-related terms appear, the strongest signals point to developmental morphogenesis in kidney and lymphatic systems.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":3},{"id":"GO:0072287","count":3},{"id":"GO:0010572","count":3},{"id":"GO:0072218","count":3},{"id":"GO:0090403","count":3}]},{"hash":"834515482052150388","title":"Inflammation, ECM Remodeling, and Coagulation","description":"The proteins are enriched for immune and inflammatory processes (leukocyte migration, defense against Gram-positive bacteria) and structural remodeling (tissue remodeling, extracellular matrix disassembly) plus coagulation-related regulation (fibrinogen levels). Some terms like transcriptional regulation and glucose response are less central, but the dominant theme links inflammation with extracellular matrix changes and coagulation, justifying this label with Medium confidence.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0003050","count":2},{"id":"GO:0045079","count":2},{"id":"GO:0002523","count":2},{"id":"GO:0050830","count":2}]},{"hash":"845940613840309319","title":"Mitochondrial Complex III Assembly and Protein Import","description":"The strongest signals are mitochondria-related: complex III assembly, positive regulation of oxidative phosphorylation, and protein insertion into the mitochondrial inner membrane, suggesting a focus on mitochondrial energy production and assembly; other terms touch on related membrane processes, supporting a mitochondria-centric cluster. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0072389","count":1},{"id":"GO:1901800","count":1},{"id":"GO:0031412","count":1},{"id":"GO:0034551","count":1},{"id":"GO:0048219","count":1}]},{"hash":"1075782571576485959","title":"Ubiquitin-Proteasome Regulation of Mitosis","description":"The top terms cluster around ubiquitin chain formation, SCF-dependent proteasomal degradation, and chromosome segregation, pointing to a set of proteins involved in ubiquitin-proteasome\u2013mediated proteolysis that drives mitotic progression. Some terms also touch on signaling regulation via proteasomal turnover (e.g., NF-kappaB, BMP pathways), supporting a cohesive theme of proteolysis governing cell cycle and signaling.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:1990920","count":4},{"id":"GO:0033128","count":4},{"id":"GO:0007059","count":4},{"id":"GO:0010976","count":4},{"id":"GO:0030509","count":4}]},{"hash":"1340078708267743233","title":"Secretory Pathway Vesicle Trafficking","description":"Based on GO terms, proteins are involved in transport of vesicles within the endomembrane system, including ER-to-Golgi, endosome-to-Golgi/late endosome, and cytoplasm-to-vacuole pathways. The presence of protein localization to the plasma membrane suggests these components participate in delivering proteins to the membrane. The combination indicates a cohesive role in vesicular trafficking in the secretory/endomembrane pathway.","confidence":"High","size":4,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032258","count":3},{"id":"GO:0034498","count":3},{"id":"GO:0045022","count":3},{"id":"GO:0006888","count":3},{"id":"GO:1903078","count":3}]},{"hash":"251436802844548775","title":"Mitochondrial Metabolite Transport","description":"The terms cluster around transport and regulation across the mitochondrial membrane (ADP, NAD, heme, PLP transport) and mitochondrial membrane permeability, with adaptive thermogenesis tying to mitochondrial energy metabolism. This coherence supports labeling the group as a mitochondrial metabolite transport cluster. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046902","count":1},{"id":"GO:1990544","count":1},{"id":"GO:1990845","count":1},{"id":"GO:0015886","count":1},{"id":"GO:0034198","count":1}]},{"hash":"2094553686243001660","title":"Wnt and Visual Signaling Regulators","description":"The proteins show enrichment for terms related to regulation of signaling pathways, notably negative regulation of canonical Wnt signaling and regulation of opsin-mediated signaling, along with visual perception and GPCR desensitization, suggesting a role in modulating both developmental signaling and sensory/GPCR signaling.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035414","count":1},{"id":"GO:0021881","count":1},{"id":"GO:0060823","count":1},{"id":"GO:0045988","count":1},{"id":"GO:0007601","count":1}]},{"hash":"2223196081593125906","title":"Neural development and axon guidance","description":"GO terms cluster around neuronal development, neuronal migration to hypothalamus, various axon guidance events (sensory neuron axon guidance, branchiomotor neuron axon guidance, trigeminal ganglion development), and cerebellar Purkinje layer development. A few terms mention sprouting angiogenesis and synaptic plasticity, but the dominant signal is neural development and neurite pathfinding, suggesting these proteins function together in shaping neural circuits rather than a single clear pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060978","count":1},{"id":"GO:0021828","count":1},{"id":"GO:0002042","count":1},{"id":"GO:0097374","count":1},{"id":"GO:0021680","count":1}]},{"hash":"1717504286656167300","title":"Magnesium Ion Homeostasis and Transport","description":"Top GO terms indicate magnesium ion handling: cellular response to Mg2+, intracellular Mg2+ homeostasis, and Mg2+ transmembrane transport, suggesting the proteins work in Mg2+ regulation and transport.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071286","count":1},{"id":"GO:0010961","count":1},{"id":"GO:1903830","count":1}]},{"hash":"2153546098410491860","title":"Lipid signaling in mucosal innate immunity","description":"This cluster ties together lipid metabolism/remodeling processes (lipid catabolic process, phosphatidic acid biosynthetic process, phospholipase activity, phosphatidylinositol remodeling) with mucosal immune functions (innate immune response in mucosa, antibacterial humoral response, defense against Gram-positive bacteria) and inflammatory mediators (prostaglandin secretion). The included ERK1/2 signaling and modulation of T cell proliferation suggest lipid-derived signals influence both innate defenses and adaptive regulation in mucosal tissues. Confidence: High","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044240","count":4},{"id":"GO:0002227","count":4},{"id":"GO:0042130","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0006654","count":4}]},{"hash":"1054650307603119484","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000350","count":1},{"id":"GO:0000389","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0000387","count":1},{"id":"GO:0048260","count":1}]},{"hash":"820977791574088561","title":"Mitosis and microtubule cytoskeleton organization","description":"This cluster is dominated by GO terms tied to cell division and microtubule dynamics, including mitotic metaphase chromosome alignment, spindle pole separation, spindle midzone assembly, and establishment/maintenance of microtubule cytoskeleton polarity, plus actomyosin contractile ring assembly for cytokinesis, indicating a cohesive role in mitosis and cytoskeleton organization (with a few additional terms like dendritic transport and stem cell homeostasis appearing as ancillary associations).","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007080","count":3},{"id":"GO:0098971","count":3},{"id":"GO:0000073","count":3},{"id":"GO:0000915","count":3},{"id":"GO:0030951","count":3}]},{"hash":"1785118915955559883","title":"Hair cell mechanosensation and ion transport","description":"These proteins show strong enrichment for GO terms related to detecting mechanical stimuli involved in sound perception and to transmembrane transport of sodium and potassium. This points to a core function in mechanosensory ion channels/transporters in sensory cells (hair-cell\u2013like function). The other terms are more peripheral. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0042511","count":1},{"id":"GO:0001886","count":1}]},{"hash":"855458107861405410","title":"Vertebrate neural and skeletal development","description":"The cluster is dominated by terms for forebrain development, neural tube closure, and skeletal system development, pointing to vertebrate embryogenesis. Co-occurring terms for DNA-templated transcription and the mitotic cell cycle suggest regulation of gene expression and proliferation during development, supporting a label centered on developmental processes and gene regulation. Some terms refer to stress or immune responses, which are less central to the core theme, yielding a moderate level of confidence.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":3}]},{"hash":"2304589127832819963","title":"Muscle development and vascular morphogenesis signaling","description":"This cluster centers on muscle formation and vascular development, as shown by myoblast fusion, cardiac hypertrophy regulation, branching in blood vessel morphogenesis, and signaling pathways like calcineurin-NFAT and Wnt calcium. Hypoxia response and transcriptional regulation terms hint at broader developmental/adaptive signaling in muscle-vascular tissues.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0051531","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0010800","count":3},{"id":"GO:1903244","count":3},{"id":"GO:0006469","count":3}]},{"hash":"1027865610502611087","title":"Muscle development and hypertrophy signaling","description":"These proteins are linked by GO terms centered on muscle growth and differentiation (myoblast fusion; regulation of cardiac muscle hypertrophy; calcineurin\u2013NFAT signaling; calcium-modulated Wnt signaling) and transcriptional regulation, all characteristic of signaling pathways driving muscle adaptation and growth. The presence of hypoxia response and branching involved in blood vessel morphogenesis indicates concurrent tissue remodeling and vascular adaptation, which often accompany muscle development and hypertrophy. Overall, the cluster appears to represent muscle development and hypertrophy signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051531","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0010800","count":3},{"id":"GO:1903244","count":3},{"id":"GO:0006469","count":3}]},{"hash":"961057443078819793","title":"Embryonic and Cardiovascular Development","description":"This cluster is dominated by GO terms for mesoderm and in utero embryonic development, with supporting terms for blood vessel morphogenesis and cardiac signaling (NFAT pathway and hypertrophy response), suggesting a focused theme on embryonic and cardiovascular development, despite some unrelated terms in the mix.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007498","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0051531","count":1},{"id":"GO:0046086","count":1}]},{"hash":"1804830200986810688","title":"Unknown","description":"The GO terms are highly diverse with only one annotation per term (regulation of calcineurin-NFAT signaling cascade, adenosine biosynthetic process, spindle-kinetochore attachment, cardiac hypertrophy in response to stress, DNA replication, meiotic DNA damage/checkpoint signaling, blood vessel branching, cocaine response, meiotic transcription regulation). There is no dominant shared process or pathway, and no edges linking proteins to indicate a cohesive function, so a meaningful, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":1},{"id":"GO:0046086","count":1},{"id":"GO:0051315","count":1},{"id":"GO:1903244","count":1},{"id":"GO:0031573","count":1}]},{"hash":"140003746683879764","title":"Neuronal apoptosis and axonogenesis regulators","description":"This cluster\u2019s GO terms center on neuronal survival and growth, including execution and regulation of apoptosis, positive regulation of programmed cell death, and axonogenesis/axon regeneration, with supporting signals from glucose- and prostaglandin-responsive pathways and cell polarity. This combination strongly suggests proteins that coordinate cell fate with axon development in neurons.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097194","count":3},{"id":"GO:0010954","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0048679","count":3},{"id":"GO:0071380","count":3}]},{"hash":"1009789281108366307","title":"Unknown","description":"The cluster has no GO terms listed (Top Terms is empty) and only a small set of proteins with a few connections, providing no clear shared function to label. Without functional signals, the appropriate label is Unknown.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"2234263624336130357","title":"Quinone biosynthesis and fatty acid metabolism","description":"The top GO terms point to biosynthesis of quinones (menaquinone and phylloquinone) and fatty acid beta-oxidation, with additional signals of antibiotic biosynthesis and various catabolic processes (valine, phenylacetate). The strongest shared theme is metabolic pathways involving quinone production and lipid (fatty acid) metabolism, typical of a bacterial metabolic cluster. Confidence: Medium","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0006574","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0006635","count":3}]},{"hash":"2134036088530283758","title":"Neuronal development and MAPK regulation","description":"Based on the top GO terms, the cluster is enriched for brain development and regulation of MAPK signaling (ERK and JNK cascades) as well as neuronal plasticity. The presence of GO:0007420 (brain development) with 2 hits, GO:0070373 (negative regulation of ERK cascade) and GO:0046328 (regulation of JNK cascade) indicate a theme of neuronal development and signaling modulation. A few terms relate to transcription or transport, but the dominant pattern points to neuronal development and MAPK pathway regulation, suggesting these proteins act as regulators of neuronal signaling or development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0070373","count":1},{"id":"GO:0045943","count":1},{"id":"GO:0010796","count":1}]},{"hash":"1578861183816319395","title":"Metabolic Processes and Transport","description":"The top GO terms point to diverse metabolic activities (fatty acid biosynthesis, purine metabolism, lactate oxidation, glucose starvation response, photorespiration) and a transport-related function (magnesium ion transmembrane transport), with one term suggesting protein complex formation. The cluster does not converge on a single clear pathway or function, but rather appears to group proteins involved in general metabolism and transport, so the label \"Metabolic Processes and Transport\" captures the broad theme without overextending to a specific pathway.","confidence":"Low","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019516","count":1},{"id":"GO:0006633","count":1},{"id":"GO:0006177","count":1},{"id":"GO:0042149","count":1},{"id":"GO:0009853","count":1}]},{"hash":"1443424392890453033","title":"Unknown","description":"The terms span immune regulation, lysosome localization, TOR signaling, GTPase activity, viral replication, ciliary transport, amino acid response, and insect neural development, with no clear shared function. The lack of cohesive biology and non-specific terms prevent a meaningful, concise label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":2},{"id":"GO:0043154","count":1},{"id":"GO:0061462","count":1},{"id":"GO:0032008","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1803577124799097282","title":"Unknown","description":"The GO terms are broad and scattered across immune processes, RNA localization, cell division, responses to various stimuli, sperm binding, and mitochondrial import. There is no single cohesive biological theme or function that ties these proteins together, so a clear, informative label cannot be assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048291","count":3},{"id":"GO:0090666","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0002931","count":3}]},{"hash":"203827424918535035","title":"Nuclear import and mitosis regulators","description":"The top GO terms strongly cluster around nuclear trafficking (tRNA export from nucleus; regulation of protein import into nucleus; NLS-bearing protein import into nucleus) and mitotic processes (mitotic nuclear membrane disassembly; mitotic metaphase chromosome alignment). Additional terms about protein complex assembly (hetero/homo-oligomerization) fit with complexes involved in transport or mitosis. Together these suggest a cohesive role in nuclear transport coupled to cell division, supporting this label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006409","count":3},{"id":"GO:0042306","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0010827","count":3},{"id":"GO:0075733","count":3}]},{"hash":"1317423786075995957","title":"Unknown","description":"Top terms are not provided, leaving no basis to identify a shared function. The cluster has only three proteins connected in a small network, but without GO annotations or recurring themes, a meaningful label cannot be assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"749730344732498270","title":"Neural development and axonogenesis","description":"The top GO terms cluster around neural development processes: axonogenesis and regulation of axon regeneration are prominent, with supporting terms related to neuronal signaling and cell polarity. Embryonic cranial skeleton morphogenesis also points to neural crest\u2013driven cranial development, together suggesting a developmental\u2013neural axis rather than general metabolism or DNA replication. Confidence in this theme is moderate since there is a mix of non-neuronal terms (e.g., DNA replication, apoptosis) alongside strong neural-related terms. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0097194","count":2},{"id":"GO:0010954","count":2},{"id":"GO:0071333","count":2}]},{"hash":"1621332065863934490","title":"GPCR-Mediated Cardiovascular and Immune Regulation","description":"The top GO terms cluster around GPCR signaling and its regulation, including dopamine receptor signaling, acetylcholine metabolism regulation, prostaglandin response, and positive regulation of GPCR pathways. Cardiovascular-related terms (renin-angiotensin\u2013mediated blood pressure, vascular smooth muscle differentiation) coexist with immune-related terms (immune response, IL-1\u03b2 production regulation), suggesting a theme of signaling-driven control of cardiovascular and immune processes. Some outliers (development, cytolysis) are present, but the core pattern supports GPCR-centered regulation of cardiovascular and immune functions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001991","count":2},{"id":"GO:0007195","count":2},{"id":"GO:0060408","count":2},{"id":"GO:0007497","count":2},{"id":"GO:0006955","count":2}]},{"hash":"1161353144101769850","title":"GPCR Signaling and Immune Modulation","description":"Top terms point to GPCR-mediated signaling and regulation of neurotransmitter pathways (dopamine, acetylcholine, prostaglandin), with several entries tied to immune responses (cytolysis, IL-1\u03b2 production). While some terms touch on development or cardiovascular differentiation, the dominant theme is GPCR signaling coupled with immune modulation, justifying this label as a concise representation of the cluster\u2019s functional signals.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001991","count":1},{"id":"GO:0007195","count":1},{"id":"GO:0060408","count":1},{"id":"GO:0007497","count":1},{"id":"GO:0006955","count":1}]},{"hash":"1596829691518141760","title":"Regulation of neuronal signaling and migration","description":"GO terms point to signaling pathways (Rho, MAPK), synaptic plasticity, and cell adhesion/migration, suggesting a module coordinating neuronal signaling with movement and development.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0048170","count":1},{"id":"GO:0043408","count":1},{"id":"GO:1904237","count":1},{"id":"GO:0070106","count":1}]},{"hash":"2119545622332304827","title":"GPCR-Mediated Vascular Signaling","description":"The terms cluster around GPCR signaling influencing vascular and cardiac functions: regulation of blood pressure via renin-angiotensin, dopamine receptor signaling, acetylcholine metabolism, prostaglandin response, and vascular smooth muscle differentiation, suggesting a shared theme of GPCR-driven regulation of cardiovascular signaling. Some terms (midgut development, IL-1 production) are less connected and may reflect broader or ancillary annotations, but the core connection is GPCR-regulated vascular/cardiac physiology.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001991","count":1},{"id":"GO:0007195","count":1},{"id":"GO:0060408","count":1},{"id":"GO:0007497","count":1},{"id":"GO:0006955","count":1}]},{"hash":"475291036493042166","title":"Actin Cytoskeleton Remodeling and Trafficking","description":"This cluster\u2019s top GO terms highlight actin-based processes and intracellular transport, such as vesicle transport along actin filaments, clathrin coat assembly, and negative regulation of actin cable assembly, along with cadherin-mediated cell adhesion. While immune signaling and development terms appear, the unifying theme appears to be actin cytoskeleton dynamics and associated trafficking, with broader signaling and adhesion contexts. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0036006","count":2},{"id":"GO:0030050","count":2},{"id":"GO:0033007","count":2},{"id":"GO:0048666","count":2}]},{"hash":"885483430572081312","title":"Ribosome maturation and translation","description":"Dominant GO terms are maturation of SSU-rRNA and translation, pointing to involvement in ribosome assembly and protein synthesis. The other terms appear as regulatory connections but the primary theme remains ribosome biogenesis/translation.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0010804","count":1},{"id":"GO:1990466","count":1},{"id":"GO:1904333","count":1}]},{"hash":"1445954088574289929","title":"Unknown","description":"The GO terms are very diverse (transcription start site selection, various cell cycle processes, several plant-specific development terms, and stress/viral-related terms), with no single dominant function linking all proteins. This makes it hard to assign a cohesive, specific label to the cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071481","count":1},{"id":"GO:0001174","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0060749","count":1},{"id":"GO:1990069","count":1}]},{"hash":"654530398296143300","title":"Unknown","description":"The terms include follicular dendritic cell differentiation, cell migration, calcium import, pinocytosis, telomere localization, and membrane depolarization, among others, with no single dominant theme. This broad spread suggests no cohesive function defining the cluster, so a generic Unknown label is appropriate.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002268","count":1},{"id":"GO:0016477","count":1},{"id":"GO:0071901","count":1},{"id":"GO:0098703","count":1},{"id":"GO:0048549","count":1}]},{"hash":"1408713890974147918","title":"Nuclear transport and mitotic regulation","description":"The GO terms cluster around nuclear processes (NLS-bearing protein import into nucleus; RNA export from nucleus; chromatin-related terms) and mitotic/cell cycle roles (spindle organization; G1/S transition; centrosome separation), suggesting a theme of coordinating nuclear transport with mitotic events. Some terms are peripheral or noisy, but the core pattern points to nuclear transport linked to mitosis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046604","count":1},{"id":"GO:0006607","count":1},{"id":"GO:0035080","count":1},{"id":"GO:0090526","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1772566125254581731","title":"Unknown","description":"There are no GO terms or interactions tying these proteins into a common function (no edges, no triangles, and no top terms). Without a detectable functional theme, the cluster is best labeled Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1271329536120511717","title":"Unknown","description":"The GO terms span diverse development (epithalamus, bronchus cartilage, heart-related development) and immune signaling (IFN-\u03b1 production, TH1 differentiation, IgA switching) with no single cohesive function tying all proteins together, so a specific, representative label cannot be determined.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060784","count":1},{"id":"GO:0060532","count":1},{"id":"GO:2000726","count":1},{"id":"GO:0003308","count":1},{"id":"GO:0071560","count":1}]},{"hash":"1018581710327890016","title":"Neural development and signaling","description":"Top GO terms point to nervous system development, neuron differentiation, and signaling (e.g., nervous system development, dopaminergic neuron axon guidance, sensory perception of sound, corticospinal tract morphogenesis). A few terms touch on unrelated processes (immune cell differentiation, integrin signaling), but the dominant theme is neural development and neuronal communication.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086073","count":1},{"id":"GO:0021957","count":1},{"id":"GO:0003273","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0007605","count":1}]},{"hash":"983496611897303846","title":"Embryonic heart and organ morphogenesis","description":"The listed GO terms cluster around developmental morphogenesis and organ specification in the embryo, with several heart-specific signals (outflow tract morphogenesis, cardioblast differentiation, cardiac muscle cell differentiation) alongside terms for brain/face morphogenesis and mesendoderm development. This suggests a shared theme of embryonic organ formation, particularly cardiac development, rather than a single isolated function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902256","count":1},{"id":"GO:0010085","count":1},{"id":"GO:0060325","count":1},{"id":"GO:2000726","count":1},{"id":"GO:0010159","count":1}]},{"hash":"175405562227576611","title":"Abiotic-stress RNA Processing","description":"This cluster\u2019s proteins are annotated mainly with RNA metabolism terms, including maturation of SSU-rRNA, tRNA processing, spliceosomal and snRNP assembly, mRNA decapping, and transcription termination, suggesting a core function in RNA processing. The presence of ABA and water deprivation response terms further implies a link between abiotic stress signaling and RNA metabolism, supporting a label centered on RNA processing under stress. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030490","count":3},{"id":"GO:0009414","count":3},{"id":"GO:0009737","count":3},{"id":"GO:0008334","count":3},{"id":"GO:0008033","count":3}]},{"hash":"1711679940609802922","title":"Neural development and synaptic signaling","description":"This cluster\u2019s GO terms cluster around neural development and synaptic organization: postsynaptic density clustering, axon guidance, neural tube closure, and social behavior. While there are a few terms related to growth signaling and immune antigen processing present as single instances, they do not form a cohesive alternative theme. Thus the dominant theme is neural development and synaptic function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097119","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0001843","count":1},{"id":"GO:0031069","count":1},{"id":"GO:0002606","count":1}]},{"hash":"405312106765305744","title":"Developmental and Immune Regulation","description":"The listed GO terms span embryonic and tissue development (in utero development, axon guidance, epithelial/bronchus development, melanocyte differentiation) as well as immune signaling (TNF production, dendritic cell antigen processing, membrane attack complex activation) and broader signaling regulation (NO and IGF receptor pathways). This suggests the cluster comprises regulators involved in both developmental processes and immune signaling, justifying a label that reflects both aspects.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033564","count":1},{"id":"GO:1901509","count":1},{"id":"GO:0010751","count":1},{"id":"GO:0060481","count":1},{"id":"GO:0001701","count":1}]},{"hash":"2041719232006638474","title":"Steroid hormone biosynthesis and vitamin D metabolism","description":"This cluster centers on biosynthetic processes for steroid hormones (aldosterone, cortisol, progesterone) and calcitriol (vitamin D), plus related P450 epoxygenase pathways. The shared theme is cytochrome P450\u2013mediated production/metabolism of lipophilic bioactive compounds, especially steroids and vitamin D.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019383","count":1},{"id":"GO:2001037","count":1},{"id":"GO:0042904","count":1},{"id":"GO:0032342","count":1},{"id":"GO:0010193","count":1}]},{"hash":"914854415962963505","title":"Rho/Rac-Mediated Actin Remodeling and Cell Migration","description":"This cluster shows enrichment for Rho and Rac signaling, lamellipodium/filopodium assembly, cell morphogenesis, neutrophil chemotaxis, and adhesion-driven cell spreading, indicating a cohesive theme of actin cytoskeleton remodeling driving cell movement and morphological changes, including immune cell migration.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035025","count":2},{"id":"GO:0086023","count":1},{"id":"GO:0030032","count":1},{"id":"GO:0043114","count":1},{"id":"GO:0035022","count":1}]},{"hash":"1410696129222904297","title":"Unknown","description":"The top GO terms cover a wide range of unrelated developmental and immune processes (heart, epithalamus, cartilage development; TGF-beta and Wnt signaling; interferon and IgA-related immune functions) with no clear common pathway or tissue-specific function across the proteins. There are no edges or shared interactions to anchor a cohesive label, so a single representative function cannot be inferred.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060784","count":1},{"id":"GO:0060532","count":1},{"id":"GO:2000726","count":1},{"id":"GO:0003308","count":1},{"id":"GO:0071560","count":1}]},{"hash":"797534207781307898","title":"RNA processing and translation initiation regulation","description":"These proteins share roles in post-transcriptional gene expression: regulation of mRNA processing (poly(A) tail shortening, alternative splicing) and regulation/assembly of the translation initiation machinery (preinitiation complex, IRES-driven initiation). The combination of spliceosome-related and translation-initiating GO terms suggests a common theme of RNA processing and translational control.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060211","count":1},{"id":"GO:0006446","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0001731","count":1}]},{"hash":"1663151621798880821","title":"Clathrin-mediated endocytosis and endosome-to-vacuole trafficking","description":"The top GO terms point to endocytosis and vesicle trafficking, especially clathrin-dependent endocytosis, clathrin coat assembly, and Golgi-to-endosome and endosome-to-vacuole transport, with receptor-mediated endocytosis regulation and vacuolar targeting. This suggests the proteins function together in clathrin-mediated endocytic pathways and related vacuolar trafficking.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048260","count":2},{"id":"GO:0009997","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0006895","count":2},{"id":"GO:0006623","count":2}]},{"hash":"2047387528215161269","title":"Large subunit ribosome biogenesis and rRNA processing","description":"The cluster\u2019s top GO terms cluster around assembly of the large ribosomal subunit preribosome, maturation and processing of LSU rRNA, and export of the large subunit from the nucleus, indicating a common role in ribosome biogenesis and rRNA maturation. A few unrelated terms (dGDP/dADP catabolic processes, RNA editing) appear but do not define the core function of the cluster.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902626","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0000466","count":1}]},{"hash":"758328662726522602","title":"Meiotic spindle assembly and chromatid segregation","description":"This cluster centers on meiosis-related processes: meiotic nuclear division, spindle elongation, cohesion and separation of sister chromatids, and regulation of the meiotic cell cycle in oocytes. Supporting terms like NLS-bearing protein import into the nucleus and protein complex assembly suggest coordination of the meiotic machinery and chromosome segregation, with some broader regulatory and protein-turnover aspects.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":3},{"id":"GO:0007143","count":3},{"id":"GO:0006461","count":3},{"id":"GO:1903538","count":3},{"id":"GO:0050790","count":3}]},{"hash":"2238869146917135836","title":"Developmental Differentiation and Angiogenesis","description":"The top GO terms span cell motility (lamellipodium assembly), endothelial processes (endothelial migration, sprouting angiogenesis, endothelial barrier establishment), and broad developmental/differentiation themes in neural and eye tissues, suggesting a general developmental/morphogenetic cluster with a tilt toward angiogenesis. Because the terms cover multiple tissues and lineages without a single precise function, the label is plausible but not tightly constrained.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":1},{"id":"GO:0051146","count":1},{"id":"GO:0042478","count":1},{"id":"GO:0060563","count":1},{"id":"GO:0097150","count":1}]},{"hash":"258720478552995165","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000495","count":1},{"id":"GO:0072327","count":1},{"id":"GO:0000472","count":1},{"id":"GO:0000480","count":1},{"id":"GO:0000447","count":1}]},{"hash":"420194467014825679","title":"Developmental Transcription and Metabolic Signaling","description":"These terms cluster around gene expression regulation (DNA-templated transcription) and developmental differentiation (somitogenesis; cardiac vascular smooth muscle and renal interstitial fibroblast development), with supporting metabolic signaling (glycolytic process, aerobic respiration regulation) and hormonal responsiveness (estradiol). Together they suggest proteins involved in coordinating transcriptional programs during development with metabolic cues, though a few terms like red light signaling or late viral transcription are less directly aligned. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:1903715","count":3},{"id":"GO:0071392","count":3},{"id":"GO:0010161","count":2},{"id":"GO:0045821","count":2}]},{"hash":"131397768835921442","title":"Ciliary and Endosomal Vesicle Trafficking","description":"The top GO terms emphasize intracellular transport, especially endosome-lysosome pathways (endosome to lysosome transport, intralumenal vesicle formation, intracellular protein transport) and protein localization to the cilium, which together point to vesicle trafficking and ciliogenesis-related processes. Though some terms touch development, the common thread is vesicle formation/trafficking and ciliary sorting, making this a cohesive cluster of vesicle trafficking proteins.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044655","count":1},{"id":"GO:0061512","count":1},{"id":"GO:0031139","count":1},{"id":"GO:0042063","count":1},{"id":"GO:0002051","count":1}]},{"hash":"1335014681126994868","title":"GPCR-Mediated Temperature and Sensory Signaling","description":"This cluster is dominated by GO terms tied to GPCR signaling and sensory/temperature-related responses (positive regulation of GPCR signaling, dopamine receptor signaling, diet-induced thermogenesis, cellular response to temperature stimulus, sensory perception of pain, prostaglandin response). This points to a common theme of GPCR-driven signaling pathways that mediate responses to temperature and sensory stimuli. Some terms appear more peripheral (blood pressure regulation, midgut development, immune response) and may reflect broader or divergent roles or dataset noise. Overall, the proteins seem to function in GPCR-mediated signaling related to temperature and sensory processing.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0001991","count":2},{"id":"GO:0007195","count":2}]},{"hash":"677354415888496627","title":"Metal-Responsive Ubiquitin-Proteasome Degradation","description":"The cluster is dominated by GO terms for ubiquitination and proteasomal protein catabolism (polyubiquitination, ubiquitin-dependent proteolysis, SCF-dependent degradation), alongside cellular responses to cadmium and arsenic. This points to a functional theme of metal-stress\u2013driven protein turnover via the ubiquitin-proteasome system, with related cell-cycle/meiosis terms reflecting broader roles in protein quality control during division. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0046685","count":1},{"id":"GO:0051436","count":1}]},{"hash":"1446512301509505739","title":"Unknown","description":"There are no GO terms or connections to define a shared function among the proteins (no edges, no terms), so a cohesive label can't be inferred from the data provided.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1008067430205630009","title":"Cytoskeleton dynamics and microtubule transport","description":"The GO terms emphasize microtubule-based movement, cytoskeleton organization, and intracellular transport, with additional signals for neuronal development and neuron projection morphogenesis. This suggests a shared function centered on cytoskeletal dynamics and microtubule-mediated transport, rather than a single specific developmental pathway, though some terms reflect neural and reproductive contexts via common cytoskeletal machinery.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0007399","count":1},{"id":"GO:0007018","count":1},{"id":"GO:0043087","count":1},{"id":"GO:0008340","count":1}]},{"hash":"2147877467349187436","title":"Developmental signaling and morphogenesis","description":"The terms point to signaling and patterning processes across development, especially neural and tissue morphogenesis: axon fasciculation and photoreceptor differentiation reflect neural development; axial mesoderm formation and boundary specification indicate early embryogenesis; regulation of MAPK and cell-matrix adhesion fit general developmental signaling and cell interactions. An outlier is IL-27 signaling, but the overall theme supports developmental signaling and morphogenesis rather than a single, narrow function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048170","count":2},{"id":"GO:0043408","count":2},{"id":"GO:1904237","count":2},{"id":"GO:0070106","count":2},{"id":"GO:0048320","count":2}]},{"hash":"42114951601703613","title":"Unknown","description":"The GO terms include renal water transport, RNA regulation, phosphoinositide metabolism, redox homeostasis, DNA catabolic process, and xenobiotic response, plus several obsolete terms. They do not point to a single, cohesive biological function for the three proteins, making it inappropriate to assign a specific label beyond Unknown.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2001153","count":2},{"id":"GO:1903507","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0043488","count":2},{"id":"GO:0045454","count":2}]},{"hash":"1875394216876409100","title":"Apoptosis and stress signaling","description":"The GO terms include execution and signaling steps of apoptosis (execution phase; extrinsic/intrinsic pathways) along with several stress-related responses (osmotic stress, staurosporine) and hormone responses, suggesting a cluster of proteins tied to apoptosis triggered by cellular stress rather than a single specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0051384","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0035234","count":2}]},{"hash":"2176964319141214176","title":"Unknown","description":"There are no GO terms represented (Top Terms are empty) and the graph has no edges, triangles, or degree, so there is no identifiable shared function among the proteins. Without functional terms to anchor a label, the appropriate designation is Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"859316134088946512","title":"Unknown","description":"The top GO terms span immune regulation, protein trafficking, signaling, metabolism, cell cycle, vascular development, cardiac remodeling, DNA replication, and drug response, with no single cohesive function. The sparse network (one edge, no triangles) supports a heterogeneous set of proteins rather than a unified pathway, so a specific label is not justifiable. ","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051531","count":1},{"id":"GO:0046086","count":1},{"id":"GO:0051315","count":1}]},{"hash":"1281494208312842455","title":"Heart and Neural Morphogenesis","description":"The GO terms point to morphogenesis in neural (corticospinal tract) and cardiac tissues (outflow tract and left ventricle), suggesting a developmental theme. While some terms concern general protein turnover and stress responses, the dominant pattern is developmental morphogenesis in heart and nervous system.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021957","count":1},{"id":"GO:0051436","count":1},{"id":"GO:0046685","count":1},{"id":"GO:0003151","count":1},{"id":"GO:0006516","count":1}]},{"hash":"380370985369428832","title":"Immune signaling and myeloid differentiation","description":"The majority of terms point to immune signaling and hematopoietic development (e.g., T/NK cell regulation, Fc receptor signaling, antigen processing via MHC II, myeloid progenitor differentiation, megakaryocyte development), suggesting a cluster of proteins involved in immune regulation within the hematopoietic lineage.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042511","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0071656","count":2},{"id":"GO:0060369","count":2},{"id":"GO:0051134","count":2}]},{"hash":"1711111991247226602","title":"Innate Immunity and MHC I Biosynthesis","description":"The top GO terms are dominated by innate immune response, defense against virus, and positive regulation of MHC class I biosynthetic process, pointing to an immune and antigen-presentation function for this cluster. A few developmental or chromatin-related terms appear as minor outliers, but they do not outweigh the primary immune signal. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0034198","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0045345","count":2},{"id":"GO:0051607","count":2}]},{"hash":"2023696498953053438","title":"Neuronal microtubule transport","description":"The terms center on microtubule-based movement, cytoskeleton regulation, and neuronal development (neuron projection morphogenesis, nervous system development). Intracellular transport of viral proteins along microtubules also fits the transport theme. While a few terms are broader or unrelated (e.g., mitotic cell cycle), the dominant pattern suggests involvement in cytoskeletal dynamics and microtubule-dependent transport in neurons.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0007018","count":1},{"id":"GO:0043087","count":1},{"id":"GO:0008340","count":1}]},{"hash":"2060597817644864839","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071051","count":1},{"id":"GO:0045006","count":1},{"id":"GO:0034475","count":1},{"id":"GO:0070651","count":1},{"id":"GO:0045830","count":1}]},{"hash":"1700704554486138597","title":"Somite and muscle development with ECM remodeling","description":"The cluster centers on developmental processes such as somite formation and skeletal muscle differentiation, and includes multiple ECM-related terms (basement membrane assembly, ECM disassembly, cell adhesion/migration, epithelial morphogenesis). While axon guidance terms are present, the prevailing pattern ties tissue patterning and morphogenesis to dynamic extracellular matrix remodeling, suggesting a module for early development and muscle-associated morphogenesis. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061053","count":2},{"id":"GO:0033564","count":1},{"id":"GO:0030334","count":1},{"id":"GO:0036514","count":1},{"id":"GO:0070831","count":1}]},{"hash":"2100681346076545305","title":"Embryogenesis and vascular development","description":"In this cluster, the prominent GO terms center on early development (primitive streak formation, PNS neuron development) and differentiation of vascular/hematopoietic lineages (angioblast differentiation, erythrocyte differentiation, blood circulation). Together they point to embryonic development with a focus on forming the circulatory system and related tissues, with some regulatory processes involved. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090009","count":2},{"id":"GO:0048935","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0045347","count":1},{"id":"GO:0035779","count":1}]},{"hash":"1919851383464924404","title":"Axon Guidance and Synaptic Development","description":"The cluster centers on neural wiring and synapse formation/plasticity: axon fasciculation, ephrin signaling, dendritic spine morphogenesis/development, corpus callosum development, and long-term synaptic plasticity, with related adhesion/migration terms.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048170","count":2},{"id":"GO:0002042","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0097156","count":2},{"id":"GO:0060997","count":2}]},{"hash":"2169865261613704397","title":"Neural Axon Guidance and Cranial Nerve Development","description":"The top GO terms are dominated by neuronal development and axon guidance, including sensory neuron axon guidance, branchiomotor neuron axon guidance, facial nerve and vestibulocochlear nerve structural organization, trigeminal ganglion development, and axon extension in guidance, suggesting a cohesive theme of neural connectivity and cranial nerve formation. A few terms (cellular defense regulation, angiogenesis, platelet activation) are less central and may reflect broader context or annotations, but do not outweigh the neural wiring signal.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010185","count":1},{"id":"GO:0060978","count":1},{"id":"GO:0021828","count":1},{"id":"GO:0097374","count":1},{"id":"GO:0021785","count":1}]},{"hash":"937226254978480797","title":"Translation and Translational Fidelity","description":"The top GO terms cluster around protein synthesis: translation in general, mitochondrial translation, selenocysteine incorporation, and maintenance of translational fidelity. Deadenylation-dependent mRNA decay also relates to translation efficiency, supporting a cohesive theme of the translation machinery. Some other terms (e.g., skeletal muscle differentiation, BDNF response) appear incidental and not core to the cluster\u2019s primary function. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0035914","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0032543","count":1},{"id":"GO:0001514","count":1}]},{"hash":"1740546283076252859","title":"Membrane Transport and pH Regulation","description":"The top GO terms cluster around transmembrane transport (fructose, oxalate, sulfate, bicarbonate) and processes affecting membrane potential and intracellular pH, pointing to transporter activity and ion/homeostasis roles. A few outlier terms (gastric acid secretion, sensory perception of sound, sporulation) are present but do not outweigh the transport-focused signal. Overall, the cluster seems best described by membrane transport and pH regulation functions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0001696","count":1},{"id":"GO:1902358","count":1},{"id":"GO:0042391","count":1},{"id":"GO:0051454","count":1}]},{"hash":"1263941582414084159","title":"Drosophila ovarian oogenesis and ubiquitin proteolysis","description":"Terms point to Drosophila egg chamber development (follicle cell stalk formation, germarium cyst encapsulation, axis specification) together with ubiquitin-dependent proteolysis, suggesting a set of proteins involved in oogenesis that are regulated by protein turnover.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030713","count":2},{"id":"GO:0042787","count":2},{"id":"GO:2000011","count":2},{"id":"GO:0030708","count":2},{"id":"GO:0030433","count":2}]},{"hash":"2062899155176145425","title":"Oxidative Stress Response and Protein Repair","description":"This cluster highlights terms related to responding to hydrogen peroxide and repairing or modifying proteins under oxidative stress, suggesting a shared theme of oxidative damage defense and protein quality control, despite limited data and some obsolete terms.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":1},{"id":"GO:0006464","count":1},{"id":"GO:1990355","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0030091","count":1}]},{"hash":"768015003235217773","title":"Pancreatic hormone regulation and lipid metabolism","description":"The cluster\u2019s terms cluster around insulin secretion regulation, pancreatic juice secretion, and pancreatic cell proliferation, complemented by lipid metabolism terms like triglyceride homeostasis and fat cell differentiation. Although some terms touch on estrogen response or tissue development, the strongest common theme ties to pancreatic endocrine/exocrine functions and associated lipid metabolic processes, suggesting the proteins participate in coordinating pancreatic hormone secretion with lipid metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050796","count":2},{"id":"GO:0071391","count":1},{"id":"GO:0070328","count":1},{"id":"GO:1901522","count":1},{"id":"GO:0090187","count":1}]},{"hash":"601931437585022499","title":"NF-\u03baB\u2013driven inflammatory signaling and apoptosis","description":"The dominant GO terms indicate activation of NF-kappaB-inducing kinase and apoptotic processes, with cytokine-related responses (IL-1, IL-6, IL-8) pointing to inflammatory signaling; some unrelated terms (chitin/cuticle, lung development) may reflect broader or cross-species annotations, but the core pattern supports NF-\u03baB\u2013mediated inflammation and cell death.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0071347","count":1},{"id":"GO:0070741","count":1},{"id":"GO:0072606","count":1}]},{"hash":"1561033712225544452","title":"Embryonic Organogenesis and Tissue Differentiation","description":"The terms cluster around embryonic development and organ/tissue differentiation, including placenta development, cartilage morphogenesis, pancreatic cell development, endocrine system formation, and heart-related EMT and left-right patterning, suggesting a cohesive theme of embryonic tissue differentiation and organ formation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060972","count":3}]},{"hash":"374498325452622899","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around embryogenesis, placental differentiation, cartilage morphogenesis, endocrine organ development, and left-right patterning, all pointing to tissue and organ development and morphogenesis. Although a couple of terms relate to cell cycle or protein turnover, the dominant signal is developmental differentiation and morphogenesis. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060972","count":2}]},{"hash":"1603386304076408315","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017001","count":1},{"id":"GO:0031126","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0046677","count":1}]},{"hash":"239048315205442713","title":"Hepatic lipid oxidation and acetyl-CoA metabolism","description":"These GO terms cluster around lipid and energy metabolism in the liver: fatty acid beta-oxidation, cholesterol metabolism, acetyl-CoA and propionyl-CoA turnover, and related catabolic pathways. The liver development term further supports a liver-specific context, suggesting the proteins participate in hepatic lipid oxidation and acetyl-CoA handling, a central energy-generation pathway, with a note on mitochondrial regulation of apoptosis consistent with mitochondrial metabolism. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008203","count":2},{"id":"GO:0009725","count":2},{"id":"GO:0006550","count":2},{"id":"GO:0019619","count":2},{"id":"GO:0006635","count":2}]},{"hash":"203231619840912702","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006564","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0006189","count":1},{"id":"GO:0071268","count":1},{"id":"GO:0008615","count":1}]},{"hash":"1635626805456658457","title":"Nucleotide Salvage Pathways","description":"The top GO terms point to salvage and breakdown of nucleosides/nucleotides (UMP salvage; uridine, inosine, guanosine, and deoxyguanosine catabolic processes; nicotinate nucleotide salvage), suggesting these proteins function in nucleotide recycling rather than de novo synthesis. A single term about cellular response to glucose starvation is present but does not define the cluster; overall the shared theme is nucleotide salvage/catabolism.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042149","count":1},{"id":"GO:0019284","count":1},{"id":"GO:0006218","count":1},{"id":"GO:0044206","count":1},{"id":"GO:0006161","count":1}]},{"hash":"1479515451214550294","title":"Membrane amino acid and neurotransmitter transporters","description":"The top GO terms point to transport across the plasma membrane of several amino acids and neurotransmitters (GABA, D-serine, methionine, arginine), along with related metabolic processes such as arginine catabolism and nitric oxide biosynthesis, and cell volume regulation. This constellation suggests proteins functioning as amino acid/ neurotransmitter transporters with connected metabolic signaling roles. The immune-related term (regulation of macrophage activation) may reflect broader arginine/NO\u2013related pathways in immune contexts. Overall, the cluster seems centered on membrane transport of amino acids and related signaling molecules.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015812","count":1},{"id":"GO:0042942","count":1},{"id":"GO:0098713","count":1},{"id":"GO:0006527","count":1},{"id":"GO:0006809","count":1}]},{"hash":"94607284168712934","title":"Diverse substrate membrane transporters","description":"The GO terms are dominated by transmembrane transport for a wide range of substrates (sialic acid, nitrate, galactose, fucose, vitamins) and a vesicular neurotransmitter loading term, indicating transporter activity across membranes for diverse nutrients and compounds. A few terms hint at metabolism or ciliary processes, but the strongest signal is membrane transport with varied substrates, justifying this label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000155","count":1},{"id":"GO:0046360","count":1},{"id":"GO:0015739","count":1},{"id":"GO:0015706","count":1},{"id":"GO:0042891","count":1}]},{"hash":"2002516486222478542","title":"Glutamatergic synapse formation and maturation","description":"This cluster is dominated by terms related to excitatory synapses\u2014NMDA receptor clustering, PSD95 clustering, receptor localization to the synapse, and regulation of glutamatergic transmission and AMPA receptor activity, along with dendritic spine morphogenesis and excitatory postsynaptic potentials\u2014pointing to assembly and maturation of glutamatergic synapses.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097120","count":1},{"id":"GO:0097114","count":1},{"id":"GO:0021517","count":1},{"id":"GO:0038026","count":1},{"id":"GO:0090129","count":1}]}]