{"hash":"699064066633935227","title":"Immune signaling and inflammatory regulation","description":"The top GO terms point to both adaptive and innate immune signaling, including T cell receptor signaling, TNF-mediated signaling, and stimulatory C-type lectin receptor signaling. Additional terms related to regulation of inflammation, deubiquitination, and mRNA stability suggest modulation of immune responses rather than a single metabolic pathway. While there are a few generic terms, the dominant theme is immune communication and inflammatory control, justifying this labeling.","confidence":"High","size":18,"edges":149,"triangles":754,"max_degree":17,"top_function":null,"members":[{"accession":"XP_001688031.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_061499100.1","go_terms":["GO:0035634","GO:0097194","GO:0090200","GO:0030263","GO:0019915","GO:0097202","GO:0006309","GO:1902511","GO:0010890","GO:0070242","GO:0032720","GO:0045476","GO:0001659","GO:0030512","GO:0050710","GO:0050995"]},{"accession":"XP_061510626.1","go_terms":["GO:0000289","GO:0010606","GO:0006397","GO:0034729","GO:0000245","GO:0048149","GO:1990108","GO:0071108","GO:0021551","GO:0051568","GO:0001662","GO:0035871","GO:0008583","GO:1904667","GO:0010995","GO:0070537","GO:0010992","GO:1904378","GO:0060013","GO:1903070","GO:0035520","GO:0035523","GO:0008343","GO:0044313","GO:1900425","GO:1901026","GO:0035192","GO:0006355","GO:0006511","GO:0006351","GO:0035616"]},{"accession":"XP_061515859.1","go_terms":["GO:0045190","GO:0009688","GO:0044810","GO:0090282","GO:0090419","GO:0009190","GO:0033624","GO:0021693","GO:1903468","GO:0034244","GO:1990705","GO:0032487","GO:0051237","GO:0070535","GO:0035196","GO:0072383","GO:0007249","GO:0090055","GO:0021685","GO:1905150"]},{"accession":"XP_061516618.1","go_terms":["GO:0045190","GO:0009688","GO:0044810","GO:0090282","GO:0090419","GO:0009190","GO:0033624","GO:0021693","GO:1903468","GO:0034244","GO:1990705","GO:0032487","GO:0051237","GO:0070535","GO:0035196","GO:0072383","GO:0007249","GO:0090055","GO:0021685","GO:1905150"]},{"accession":"XP_061516984.1","go_terms":["GO:0007023","GO:0031117","GO:0034126","GO:0014889","GO:0031122","GO:0048936"]},{"accession":"XP_308607.4","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_308610.5","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_312238.3","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"XP_313568.3","go_terms":["GO:0060340","GO:1901097","GO:0006468","GO:1901340","GO:0035458","GO:0000226","GO:0030010","GO:0001828","GO:0001827","GO:1903094","GO:1904153","GO:2000157","GO:0010994","GO:0035973","GO:1904378","GO:0030474","GO:0032815","GO:1903071","GO:0006289","GO:0034140","GO:0035523","GO:0030433","GO:0035278","GO:0035329","GO:0044313","GO:1900186","GO:0070059","GO:0016567","GO:1904021","GO:0006517","GO:0000423","GO:0033132","GO:1902236","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:1901799","GO:1902283","GO:0016579","GO:0017085","GO:0051865","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1904049","GO:0006412"]},{"accession":"XP_315431.3","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_315549.5","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_316606.3","go_terms":["GO:0035774","GO:0000423","GO:0032436","GO:0000266","GO:0099074","GO:0090201","GO:0033132","GO:0051865","GO:0043388","GO:0051583","GO:0036205","GO:0051412","GO:0023035","GO:0046329","GO:1903265","GO:0070936","GO:0090258","GO:0006986","GO:0070842","GO:0070979","GO:0048078","GO:0090141","GO:0010918","GO:0085020","GO:0042787","GO:1902283","GO:0071287","GO:1903427","GO:0070534","GO:0043123","GO:0060546","GO:0010636","GO:1903382","GO:2001171","GO:1902530","GO:0055069","GO:1905366","GO:0008344","GO:1903542","GO:0097039","GO:0010637","GO:0090394","GO:1904049","GO:0097237","GO:0042551","GO:0070050","GO:0006513","GO:1903378","GO:0051967","GO:0006351","GO:1903377","GO:0046676","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:1901097","GO:1902236","GO:1901340","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0034140","GO:0030433","GO:0000028","GO:0000753","GO:0071816","GO:1900186","GO:1904021","GO:0006517","GO:0006412"]},{"accession":"XP_317882.4","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032","GO:1903955","GO:0043161","GO:0042098"]},{"accession":"XP_319581.4","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_320065.4","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_321089.4","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_550827.5","go_terms":["GO:1990116","GO:1900182","GO:0030970","GO:0051228","GO:0032480","GO:0071712","GO:0072671","GO:0030433","GO:0051974","GO:0071629","GO:0070651","GO:0039536"]}],"graph":[["XP_315549.5","XP_001688031.1",0.951],["XP_315549.5","XP_061499100.1",0.814],["XP_315549.5","XP_061510626.1",0.926],["XP_315549.5","XP_061515859.1",0.99],["XP_315549.5","XP_061516618.1",0.978],["XP_315549.5","XP_061516984.1",0.943],["XP_315549.5","XP_308607.4",0.976],["XP_315549.5","XP_308610.5",0.954],["XP_315549.5","XP_312238.3",0.981],["XP_315549.5","XP_313568.3",0.778],["XP_315549.5","XP_550827.5",0.954],["XP_315549.5","XP_321089.4",0.919],["XP_315549.5","XP_319581.4",0.977],["XP_315549.5","XP_320065.4",0.908],["XP_315549.5","XP_315431.3",0.884],["XP_315549.5","XP_316606.3",0.952],["XP_315549.5","XP_317882.4",0.976],["XP_550827.5","XP_001688031.1",0.974],["XP_550827.5","XP_061499100.1",0.908],["XP_550827.5","XP_061510626.1",0.928],["XP_550827.5","XP_061515859.1",0.924],["XP_550827.5","XP_061516618.1",0.939],["XP_550827.5","XP_061516984.1",0.973],["XP_550827.5","XP_308607.4",0.968],["XP_550827.5","XP_308610.5",0.974],["XP_550827.5","XP_312238.3",0.974],["XP_550827.5","XP_313568.3",0.984],["XP_550827.5","XP_315431.3",0.95],["XP_550827.5","XP_316606.3",0.982],["XP_550827.5","XP_317882.4",0.9],["XP_550827.5","XP_319581.4",0.917],["XP_550827.5","XP_320065.4",0.625],["XP_550827.5","XP_321089.4",0.922],["XP_061510626.1","XP_001688031.1",0.964],["XP_061510626.1","XP_061515859.1",0.94],["XP_061510626.1","XP_061516618.1",0.832],["XP_061510626.1","XP_061516984.1",0.966],["XP_061510626.1","XP_308607.4",0.937],["XP_061510626.1","XP_308610.5",0.911],["XP_061510626.1","XP_312238.3",0.941],["XP_061510626.1","XP_313568.3",0.888],["XP_061510626.1","XP_315431.3",0.848],["XP_061510626.1","XP_316606.3",0.943],["XP_061510626.1","XP_317882.4",0.847],["XP_061510626.1","XP_319581.4",0.808],["XP_061510626.1","XP_321089.4",0.749],["XP_317882.4","XP_001688031.1",0.919],["XP_317882.4","XP_061499100.1",0.657],["XP_317882.4","XP_061515859.1",0.872],["XP_317882.4","XP_061516618.1",0.904],["XP_317882.4","XP_061516984.1",0.984],["XP_317882.4","XP_308607.4",0.953],["XP_317882.4","XP_308610.5",0.916],["XP_317882.4","XP_312238.3",0.964],["XP_317882.4","XP_313568.3",0.967],["XP_317882.4","XP_315431.3",0.939],["XP_317882.4","XP_316606.3",0.964],["XP_317882.4","XP_319581.4",0.803],["XP_317882.4","XP_320065.4",0.931],["XP_317882.4","XP_321089.4",0.946],["XP_001688031.1","XP_061499100.1",0.924],["XP_001688031.1","XP_061515859.1",0.823],["XP_001688031.1","XP_061516618.1",0.829],["XP_001688031.1","XP_061516984.1",0.971],["XP_001688031.1","XP_308607.4",0.956],["XP_001688031.1","XP_308610.5",0.983],["XP_001688031.1","XP_312238.3",0.961],["XP_001688031.1","XP_313568.3",0.949],["XP_001688031.1","XP_315431.3",0.967],["XP_001688031.1","XP_316606.3",0.99],["XP_001688031.1","XP_319581.4",0.875],["XP_001688031.1","XP_320065.4",0.956],["XP_001688031.1","XP_321089.4",0.958],["XP_319581.4","XP_061499100.1",0.589],["XP_319581.4","XP_061515859.1",0.967],["XP_319581.4","XP_061516618.1",0.963],["XP_319581.4","XP_061516984.1",0.955],["XP_319581.4","XP_308607.4",0.98],["XP_319581.4","XP_308610.5",0.888],["XP_319581.4","XP_312238.3",0.97],["XP_319581.4","XP_313568.3",0.956],["XP_319581.4","XP_315431.3",0.853],["XP_319581.4","XP_316606.3",0.924],["XP_319581.4","XP_320065.4",0.844],["XP_319581.4","XP_321089.4",0.807],["XP_320065.4","XP_061515859.1",0.689],["XP_320065.4","XP_061516618.1",0.879],["XP_320065.4","XP_061516984.1",0.909],["XP_320065.4","XP_308607.4",0.833],["XP_320065.4","XP_308610.5",0.906],["XP_320065.4","XP_312238.3",0.889],["XP_320065.4","XP_313568.3",0.629],["XP_320065.4","XP_315431.3",0.582],["XP_320065.4","XP_316606.3",0.773],["XP_320065.4","XP_321089.4",0.586],["XP_312238.3","XP_061499100.1",0.939],["XP_312238.3","XP_061515859.1",0.989],["XP_312238.3","XP_061516618.1",0.982],["XP_312238.3","XP_061516984.1",0.967],["XP_312238.3","XP_308607.4",0.981],["XP_312238.3","XP_308610.5",0.96],["XP_312238.3","XP_321089.4",0.952],["XP_312238.3","XP_316606.3",0.982],["XP_312238.3","XP_315431.3",0.912],["XP_312238.3","XP_313568.3",0.991],["XP_061516618.1","XP_061499100.1",0.635],["XP_061516618.1","XP_061515859.1",0.96],["XP_061516618.1","XP_061516984.1",0.978],["XP_061516618.1","XP_308607.4",0.984],["XP_061516618.1","XP_308610.5",0.957],["XP_061516618.1","XP_315431.3",0.734],["XP_061516618.1","XP_316606.3",0.977],["XP_061516618.1","XP_321089.4",0.816],["XP_315431.3","XP_061499100.1",0.675],["XP_315431.3","XP_061515859.1",0.936],["XP_315431.3","XP_061516984.1",0.952],["XP_315431.3","XP_308607.4",0.908],["XP_315431.3","XP_308610.5",0.97],["XP_315431.3","XP_313568.3",0.887],["XP_315431.3","XP_321089.4",0.903],["XP_315431.3","XP_316606.3",0.968],["XP_061515859.1","XP_061499100.1",0.697],["XP_061515859.1","XP_061516984.1",0.979],["XP_061515859.1","XP_308607.4",0.99],["XP_061515859.1","XP_308610.5",0.951],["XP_061515859.1","XP_313568.3",0.975],["XP_061515859.1","XP_316606.3",0.936],["XP_061515859.1","XP_321089.4",0.923],["XP_321089.4","XP_061499100.1",0.818],["XP_321089.4","XP_061516984.1",0.964],["XP_321089.4","XP_308607.4",0.923],["XP_321089.4","XP_308610.5",0.95],["XP_321089.4","XP_313568.3",0.853],["XP_321089.4","XP_316606.3",0.848],["XP_313568.3","XP_061499100.1",0.643],["XP_313568.3","XP_061516984.1",0.99],["XP_313568.3","XP_308607.4",0.891],["XP_313568.3","XP_308610.5",0.945],["XP_313568.3","XP_316606.3",0.992],["XP_308607.4","XP_061499100.1",0.813],["XP_308607.4","XP_061516984.1",0.98],["XP_308607.4","XP_308610.5",0.962],["XP_308607.4","XP_316606.3",0.973],["XP_061499100.1","XP_316606.3",0.864],["XP_061499100.1","XP_308610.5",0.91],["XP_061499100.1","XP_061516984.1",0.836],["XP_316606.3","XP_061516984.1",0.989],["XP_316606.3","XP_308610.5",0.976],["XP_061516984.1","XP_308610.5",0.902]],"all_go_terms":{"GO:0032387":4,"GO:0050821":4,"GO:0006936":4,"GO:1900034":4,"GO:0007568":4,"GO:0032355":4,"GO:2000378":4,"GO:0051403":4,"GO:0070141":4,"GO:0071480":4,"GO:0070309":4,"GO:1905907":4,"GO:0009644":4,"GO:0032463":4,"GO:0099641":4,"GO:0031109":4,"GO:0030308":4,"GO:0042542":4,"GO:0009408":4,"GO:0001659":1,"GO:1902511":1,"GO:0032720":1,"GO:0050710":1,"GO:0035634":1,"GO:0006309":1,"GO:0030512":1,"GO:0050995":1,"GO:0045476":1,"GO:0019915":1,"GO:0070242":1,"GO:0030263":1,"GO:0097194":1,"GO:0010890":1,"GO:0090200":1,"GO:0097202":1,"GO:0010606":1,"GO:1901026":1,"GO:0021551":1,"GO:1990108":1,"GO:0071108":1,"GO:1904378":3,"GO:0010995":1,"GO:0035520":1,"GO:0010992":1,"GO:0070537":1,"GO:0034729":1,"GO:0000245":1,"GO:0008583":1,"GO:1900425":1,"GO:0048149":1,"GO:0006351":2,"GO:0006397":1,"GO:0060013":1,"GO:0035523":2,"GO:0044313":2,"GO:1903070":1,"GO:0006511":1,"GO:0006355":1,"GO:0035616":1,"GO:0001662":1,"GO:0035192":1,"GO:0035871":1,"GO:0051568":1,"GO:1904667":1,"GO:0008343":1,"GO:0000289":1,"GO:1990705":2,"GO:0035196":2,"GO:1905150":2,"GO:1903468":2,"GO:0090055":2,"GO:0007249":2,"GO:0045190":2,"GO:0021693":2,"GO:0044810":2,"GO:0032487":2,"GO:0072383":2,"GO:0009190":2,"GO:0090419":2,"GO:0070535":2,"GO:0033624":2,"GO:0021685":2,"GO:0009688":2,"GO:0051237":2,"GO:0034244":2,"GO:0090282":2,"GO:0034126":2,"GO:0031117":1,"GO:0048936":1,"GO:0014889":1,"GO:0007023":1,"GO:0031122":1,"GO:0097352":1,"GO:0010940":1,"GO:0006501":1,"GO:0010288":1,"GO:0000226":2,"GO:0071280":1,"GO:0070301":1,"GO:0070257":1,"GO:0061723":1,"GO:0040024":1,"GO:0006888":1,"GO:0061709":1,"GO:0034727":1,"GO:0032258":1,"GO:0006915":1,"GO:0071211":1,"GO:0034198":1,"GO:0000422":1,"GO:0035096":1,"GO:0010040":1,"GO:0008625":1,"GO:0043278":1,"GO:0034629":1,"GO:0044805":1,"GO:0000045":1,"GO:1905366":2,"GO:1903094":1,"GO:0030474":2,"GO:1901799":2,"GO:0000753":2,"GO:0017085":2,"GO:1902283":2,"GO:0035973":2,"GO:0035458":1,"GO:1904049":2,"GO:0016579":7,"GO:0070059":1,"GO:0010636":2,"GO:0097237":2,"GO:0000423":2,"GO:0033132":2,"GO:0045648":2,"GO:2000157":1,"GO:0034140":2,"GO:0016925":2,"GO:0001827":1,"GO:1900186":2,"GO:0010216":2,"GO:0006517":2,"GO:0006289":2,"GO:0016567":1,"GO:0035278":1,"GO:1904021":2,"GO:1903071":2,"GO:0071816":2,"GO:0006412":2,"GO:0002109":2,"GO:0070842":2,"GO:1901340":2,"GO:1901097":2,"GO:0001828":1,"GO:1904153":1,"GO:0030010":1,"GO:0010994":1,"GO:0030433":3,"GO:0035329":1,"GO:0021888":2,"GO:0051865":2,"GO:0000028":2,"GO:0010637":2,"GO:0014070":2,"GO:0032815":1,"GO:0006357":2,"GO:1903265":2,"GO:0006468":1,"GO:1902236":2,"GO:0060340":1,"GO:0050852":5,"GO:0031145":5,"GO:0033209":5,"GO:0061418":5,"GO:0002223":5,"GO:0006521":5,"GO:0002862":5,"GO:0010950":5,"GO:0043488":5,"GO:0031146":5,"GO:0010043":5,"GO:0010972":5,"GO:0060071":5,"GO:0046686":5,"GO:0010363":5,"GO:0010499":5,"GO:0051436":5,"GO:0038061":5,"GO:0090090":5,"GO:0009651":5,"GO:0051437":5,"GO:0090263":5,"GO:0038095":5,"GO:0016032":5,"GO:0080129":5,"GO:0002479":5,"GO:2001171":1,"GO:0043388":1,"GO:1901896":1,"GO:0070936":1,"GO:0046329":1,"GO:1903378":1,"GO:0071276":1,"GO:0048078":1,"GO:0070979":1,"GO:0070050":1,"GO:0051967":1,"GO:0042787":1,"GO:0046676":1,"GO:1902260":1,"GO:0032436":1,"GO:0006986":1,"GO:0045759":1,"GO:1903377":1,"GO:0043433":1,"GO:0085020":1,"GO:0097039":1,"GO:0035186":1,"GO:0090258":1,"GO:0035774":1,"GO:0099074":1,"GO:0071287":1,"GO:0023035":1,"GO:0043392":1,"GO:0006513":1,"GO:1903382":1,"GO:1903427":1,"GO:0000266":1,"GO:0090204":1,"GO:0060546":1,"GO:0008344":1,"GO:0090141":1,"GO:0030578":1,"GO:0045944":1,"GO:0051412":1,"GO:0036205":1,"GO:0010918":1,"GO:0070534":1,"GO:0055069":1,"GO:0051572":1,"GO:1903542":1,"GO:0090394":1,"GO:0060334":1,"GO:0043123":1,"GO:0090201":1,"GO:0042551":1,"GO:0070911":1,"GO:0086004":1,"GO:1902530":1,"GO:0010286":1,"GO:0051583":1,"GO:0042098":1,"GO:0043161":1,"GO:1903955":1,"GO:0030970":1,"GO:0071629":1,"GO:0072671":1,"GO:0051974":1,"GO:0071712":1,"GO:1900182":1,"GO:0039536":1,"GO:0070651":1,"GO:0051228":1,"GO:0032480":1,"GO:1990116":1},"recipe_readded":[]}