[{"hash":"1090959764056460583","title":"GTPase-regulated vesicle trafficking in neurons","description":"This cluster shows enrichment for GTPase regulatory processes (Ras, Rho), vesicle transport and endocytosis, and neuronal synaptic functions (synaptic vesicle maturation, brain development). The presence of Ras/Rho regulation and ubiquitin-dependent endocytosis supports a role in controlling vesicle trafficking and signaling in neural cells.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006886","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0002692","count":3},{"id":"GO:0046580","count":3}]},{"hash":"666380792763846339","title":"Embryonic organogenesis and transcriptional regulation","description":"The cluster's top GO terms center on DNA-templated transcription and transcriptional regulation, alongside diverse embryonic development processes across multiple organs (endocrine pancreas, otic placode, lacrimal gland, neural crest migration, digestive tract morphogenesis, skeletal muscle differentiation, ureteric bud branching). This pattern points to a coordinated developmental gene-expression program driving organogenesis, with a peripheral metabolic term (L-alanine catabolic process) that does not disrupt the overall theme.","confidence":"High","size":29,"edges":28,"triangles":10,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0000122","count":9},{"id":"GO:0090190","count":8},{"id":"GO:0042853","count":6},{"id":"GO:0031018","count":6}]},{"hash":"554283657716232193","title":"Translation and Metabolic Signaling Cluster","description":"This cluster prominently features cytoplasmic translation and the TCA cycle, with supporting redox, calcium signaling, and cAMP response terms, plus angiogenesis-related terms. This pattern suggests a group of proteins involved in protein synthesis intertwined with energy metabolism and signaling pathways, potentially coordinating translation with metabolic status and calcium/cAMP signaling. The presence of angiogenesis and muscle activity signals may reflect broader multifunctionality across members.","confidence":"High","size":29,"edges":368,"triangles":2761,"max_degree":28,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0006099","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0070588","count":3},{"id":"GO:0051591","count":3}]},{"hash":"195555824016449088","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000480","count":7},{"id":"GO:0000472","count":7},{"id":"GO:0000463","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0000398","count":5}]},{"hash":"1912039394608311487","title":"Stress and immune response cluster","description":"The top GO terms point to responses to temperature stimulus and thermogenesis, pain perception, and immune-related processes (viral release from host cell and macrophage activation). While there are also terms for development and locomotion, the strongest signals are stress/immune related, suggesting a cluster centered on host response to stress and infection.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0019076","count":7},{"id":"GO:0042116","count":7}]},{"hash":"517434561643775005","title":"Vascular signaling and ECM remodeling","description":"Based on the top GO terms, this cluster centers on signaling pathways that regulate blood vessel function and extracellular matrix dynamics: positive regulation of GTPase activity and ERK1/2 cascade point to growth signaling; regulation of vasoconstriction and negative regulation of angiogenesis highlight vascular remodeling; collagen fibril organization and response to mechanical stimulus reflect ECM remodeling in vessels. While there are some terms related to transcription and neuronal spines, the strongest and most coherent theme is signaling that governs vascular structure and its ECM context.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0045907","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0070374","count":3}]},{"hash":"1365258007617675186","title":"Unknown","description":"The GO terms across this cluster cover insect cuticle development, lipoprotein assembly, spermatid differentiation, mitotic cleavage, cell migration, membrane tubulation, hepatocyte apoptosis, ultradian rhythm, Golgi transport (obsolete), and dendritic spine development. There is no clear, single functional theme tying these terms together, and the cluster shows no internal edges, suggesting weak or diverse functional linkage. Therefore a cohesive label is not ascertainable.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0034379","count":2},{"id":"GO:0007289","count":2},{"id":"GO:1990386","count":2},{"id":"GO:0016477","count":2}]},{"hash":"1416603312862191533","title":"Developmental signaling and cell-cycle regulation","description":"This cluster centers on cell division and mitotic cell cycle terms, with several development-related terms (nervous system and kidney development) and signaling pathways (ERK cascade, Smoothened, T cell receptor). Trafficking processes (ER-Golgi transport, endocytosis) further link signaling to cell-cycle and developmental regulation, suggesting a cohesive theme of development-associated signaling coordinating division. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0006623","count":5}]},{"hash":"1425428403315399779","title":"Developmental Signaling and Axon Guidance","description":"The set is enriched for developmental processes including nervous system development, axon guidance, and organogenesis (kidney, spermatid development) with signaling pathway components such as Smoothened (SHH) and Roundabout (ROBO) and ERK cascades, indicating a cohesive module of developmental signaling and neural patterning.","confidence":"Medium","size":29,"edges":27,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":9},{"id":"GO:0043552","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0007224","count":8},{"id":"GO:0035385","count":8}]},{"hash":"2097410978919172111","title":"Ubiquitin-Dependent Protein Degradation & Immune Signaling","description":"The top terms show strong enrichment for ubiquitin-mediated proteolysis (ubiquitin-dependent catabolic process, ERAD, protein ubiquitination) and linked signaling/immune functions (JNK and TNF signaling, V(D)J recombination, antiviral host responses), suggesting a cluster centered on ubiquitin-proteasome\u2013driven protein turnover and regulation of immune pathways.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0030433","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0046328","count":6},{"id":"GO:1903265","count":6}]},{"hash":"907863114236274662","title":"DNA repair and translation regulation","description":"The cluster is enriched for DNA maintenance activities (DNA replication, repair, and recombination) alongside translation-related processes (translation and regulation of translational fidelity). Additional terms related to nucleotide metabolism (diadenosine tetraphosphate catabolism and purine catabolism) support a link between genome maintenance and nucleotide/protein synthesis. This suggests a functional module where DNA repair/replication processes are coordinated with translation control, possibly under stress or replication-challenged conditions.","confidence":"Medium","size":29,"edges":9,"triangles":5,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006281","count":5},{"id":"GO:0015967","count":3},{"id":"GO:0006450","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1648496190401663550","title":"Developmental signaling and cytoskeletal regulation","description":"The top GO terms point to development-related processes (bone development, stem cell proliferation), signaling pathways (B cell receptor signaling, Fc receptor signaling, regulation of GTPase activity), and cytoskeletal dynamics (actin filament polymerization, synaptic vesicle uncoating), with an additional apoptotic process term. This suggests a cluster of proteins involved in developmental signaling that integrates cytoskeletal remodeling and immune signaling, rather than a single highly specific function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0060348","count":4},{"id":"GO:0048681","count":3},{"id":"GO:0016191","count":3},{"id":"GO:0030041","count":3}]},{"hash":"425228585130768373","title":"Innate Immune Response and Signaling","description":"The top GO terms are dominated by innate immune and signaling activities: cellular response to lipopolysaccharide, complement activation, positive/negative regulation of signaling (ERK cascade, phosphorylation), and apoptosis. While there are also terms related to cholesterol homeostasis and sensory or developmental processes, the strongest and most coherent signal across the cluster points to immune sensing and downstream signaling pathways. This suggests a core theme of innate immune response and associated signaling, with some unrelated peripheral processes sprinkled in.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0042632","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0007601","count":4}]},{"hash":"1138353848573496055","title":"Inflammatory immune and coagulation signaling","description":"This cluster prominently features adaptive immune response and coagulation/fibrinolysis terms, with exocytosis and NF-kappaB signaling indicating secreted inflammatory mediators driving responses. The inclusion of vasoconstriction regulation and negative regulation of cell-substrate adhesion suggests vascular and tissue remodeling aspects tied to inflammation. The sparse connectivity supports a loose assembly of proteins spanning immune activation, coagulation, and vascular regulation rather than a single, cohesive complex. Hence a label like \"Inflammatory immune and coagulation signaling\" captures the main theme.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045921","count":7},{"id":"GO:0033689","count":6},{"id":"GO:0002250","count":6},{"id":"GO:0072378","count":6},{"id":"GO:0010812","count":6}]},{"hash":"1765945098002202528","title":"Mycobacterial Capsule and Cell Wall Biosynthesis","description":"The top GO terms are dominated by capsule polysaccharide biosynthetic process, mycolate cell wall layer assembly, and cell wall polysaccharide biosynthetic process, with supporting carbohydrate metabolism (UDP-D-galactose and general carbohydrate metabolic processes). This points to a coherent theme of cell wall and capsule component synthesis typical of mycobacteria, making the label intuitive. Some DNA replication/transcription terms appear but are less central to the cluster\u2019s main signal.","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070940","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0045227","count":3}]},{"hash":"249190776934394454","title":"Mitochondrial protein synthesis and energy metabolism","description":"The cluster centers on mitochondrial translation and respiration, with GO terms spanning translation, mitochondrial electron transport, proton-driven ATP synthesis, and respiration, pointing to coordinated mitochondrial gene expression and oxidative phosphorylation.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006123","count":4},{"id":"GO:0015986","count":2},{"id":"GO:0046496","count":1},{"id":"GO:0031087","count":1}]},{"hash":"568005717035989323","title":"Translational Initiation Control and RNA Processing","description":"The top GO terms center on translation initiation and reinitiation, preinitiation complex formation, and regulation of translation, complemented by RNA processing/regulation activities (mRNA stability under stress, splicing regulation, ncRNA-mediated silencing). Together, they point to a cluster of proteins coordinating translation initiation with RNA metabolism and stress responses, including viral translation mechanisms. ","confidence":"High","size":28,"edges":27,"triangles":5,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":16},{"id":"GO:0010610","count":16},{"id":"GO:0002188","count":16},{"id":"GO:0075525","count":14},{"id":"GO:0006446","count":14}]},{"hash":"1432196596727812642","title":"Stress-responsive RNA processing and splicing","description":"The top GO terms cluster around RNA metabolism\u2014splicing via the spliceosome, mRNA stability regulation in response to stress, and mRNA modification\u2014suggesting a core function in RNA processing that is modulated by stress. Additional terms touching on transcription-related processes and minor immune or contextual responses (lipopolysaccharide, heparin) likely reflect secondary signals or organismal context. Overall, a cohesive theme of RNA processing under stress.","confidence":"High","size":28,"edges":41,"triangles":26,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0010738","count":2},{"id":"GO:0060009","count":2},{"id":"GO:0071504","count":2}]},{"hash":"1887930350877014902","title":"Retinal development and dopaminergic signaling","description":"This cluster is strongly enriched for retina-related terms (retina development, visual perception) and dopaminergic synaptic transmission, suggesting a module of proteins involved in retinal signaling and dopamine-mediated vision. The presence of GPCR signaling, adenylate cyclase activation, and ERK cascade regulation indicates a broader signal transduction network that controls retinal neuron communication and growth/proliferation responses. Overall, the data point to a cohesive retina- and dopamine-centered signaling cluster.","confidence":"High","size":28,"edges":120,"triangles":225,"max_degree":22,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008284","count":25},{"id":"GO:0043547","count":25},{"id":"GO:0008283","count":25},{"id":"GO:0060041","count":25},{"id":"GO:0001963","count":23}]},{"hash":"698655613252414059","title":"Neuronal plasticity and neurotransmitter transport","description":"This cluster is dominated by GO terms for long-term synaptic potentiation and depression, and acetylcholine biosynthesis, pointing to neural signaling and neurotransmitter production. The presence of multiple transmembrane transport terms (glucose, myo-inositol, pantothenate, biotin) suggests associated metabolic support across the membrane in neurons. Immune terms are present but appear less cohesive with the main neuronal theme, so the label focuses on neural signaling and transporter-mediated metabolism.","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0071436","count":4}]},{"hash":"125251890092054690","title":"Insect larval cuticle development","description":"The cluster is dominated by larval chitin-based cuticle development (GO:0008363) with 11 proteins, suggesting a core function in insect exoskeleton formation. Other terms point to immune and signaling roles (positive regulation of Toll signaling, response to yeast, cellular response to transforming growth factor beta) and membrane-associated activities (sodium and potassium ion transport), which can accompany cuticle biosynthesis in developing epithelia. Overall, the most representative theme is larval cuticle biosynthesis, with ancillary signaling and transport processes.","confidence":"Medium","size":28,"edges":191,"triangles":451,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0000122","count":3},{"id":"GO:0001878","count":3},{"id":"GO:0097186","count":3},{"id":"GO:0045752","count":3}]},{"hash":"1513291258419928799","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":77,"triangles":62,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008363","count":12},{"id":"GO:0036494","count":5},{"id":"GO:0034975","count":5},{"id":"GO:0006986","count":5},{"id":"GO:0006458","count":5}]},{"hash":"392480751070328440","title":"Neuronal development and synaptic signaling","description":"The top GO terms cluster around nervous system development, dendritic spine development, and sensory perception of touch, suggesting roles in neural growth and synaptic formation. Supporting terms point to signaling cascades (ERK), phosphorylation, Hedgehog signaling, cytoskeletal dynamics (stress fiber assembly), and protein trafficking, all of which are key for neurite outgrowth, spine maturation, and neuronal communication. While some terms reflect general cellular processes, the overall theme is neural development and synaptic signaling rather than housekeeping functions. ","confidence":"Medium","size":28,"edges":27,"triangles":0,"max_degree":11,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0043149","count":7},{"id":"GO:0050975","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0070374","count":7},{"id":"GO:0033138","count":7}]},{"hash":"1719812655341486762","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":1},{"id":"GO:0045948","count":1},{"id":"GO:0034402","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0006281","count":1}]},{"hash":"17476471401315155","title":"Multitissue Development","description":"This cluster is dominated by GO terms describing development across multiple tissues (retina, osteoblasts, skeletal muscle, neural crest, pituitary, pancreas) and general multicellular organism development, suggesting proteins involved in broad developmental regulation rather than a single tissue-specific pathway. The terms also include transcriptional regulation, reinforcing a role in gene expression control during development. The edges are sparse, indicating diverse, loosely connected developmental annotations rather than a tight pathway.","confidence":"Medium","size":28,"edges":4,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":12},{"id":"GO:0002087","count":11},{"id":"GO:0002076","count":11},{"id":"GO:0007519","count":11},{"id":"GO:0007275","count":11}]},{"hash":"1787953366526522461","title":"Synaptic signaling and plasticity regulation","description":"These proteins cluster around neuronal communication and modulation of synapses: neurotransmitter secretion, glutamatergic transmission, and positive regulation of synaptic plasticity, with supporting roles in nitric oxide signaling, calcium transport regulation, and receptor clustering. The collection points to a cohesive theme of regulating synaptic strength and signaling dynamics in neurons.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007269","count":7},{"id":"GO:0055114","count":7},{"id":"GO:0031915","count":6},{"id":"GO:0045429","count":5},{"id":"GO:0051926","count":5}]},{"hash":"14413533686163015","title":"Polyamine biosynthesis and transport","description":"The cluster shows strong enrichment for spermidine biosynthetic and nor-spermidine biosynthetic processes, plus positive regulation of polyamine transmembrane transport, which together point to a cohesive polyamine metabolism and transport module. Additional related terms like arginine catabolic processes can feed into polyamine pathways, while a few unrelated terms may reflect annotation noise or broader metabolic roles.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0015979","count":4},{"id":"GO:0009228","count":4},{"id":"GO:0042420","count":3},{"id":"GO:0008295","count":3}]},{"hash":"1548737104518312977","title":"Embryonic development and morphogenesis","description":"The terms cluster around developmental processes: trophoblast giant cell differentiation and placenta-related development, cartilage morphogenesis, endocrine system development, left-right patterning, pancreatic cell development, and EMT in heart development. Together they point to embryogenesis and tissue morphogenesis as the core function of this protein set, with occasional housekeeping processes (mRNA splicing and ribosomal export) that are common in many proteins but less central to the cluster\u2019s theme. This suggests a coherent, though not exclusively dev-specific, theme of developmental differentiation and morphogenesis.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4}]},{"hash":"1507195772958372703","title":"Unknown","description":"The proteins encompass a broad mix of functions including transcription, cell cycle, stress responses, signaling, RNA transport, and development, with no single cohesive biological process dominating the set, making a precise, specific label difficult to justify.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0009408","count":3}]},{"hash":"1958686531768837253","title":"Hormone and Lipid Mediator Biosynthesis","description":"Most prominent GO terms point to biosynthesis of signaling molecules and hormones, including prostaglandin biosynthesis, retinoic acid biosynthesis, and ecdysone biosynthesis, as well as aldosterone-regulated processes. This suggests a coherent theme around production and regulation of signaling molecules, with additional, more peripheral terms related to stress responses and development. Given the mixture, the name captures the central thread without overreaching.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":19},{"id":"GO:0035902","count":18},{"id":"GO:1900087","count":18},{"id":"GO:0019341","count":18},{"id":"GO:2001037","count":18}]},{"hash":"1771197362816739880","title":"Cell cycle and RNA processing cluster","description":"The top GO terms cluster around core nuclear processes: DNA replication and mitotic cell cycle/cell division point to proliferation, while mRNA splicing via spliceosome highlights RNA processing. Additional terms related to signaling regulation (GTPase activity, autophosphorylation) and tissue regeneration/differentiation suggest contexts where proliferation and gene expression are coordinated. Together, these indicate a cluster centered on cell cycle progression and basic gene-expression machinery, with regulatory and differentiation contexts.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0097421","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0060487","count":3},{"id":"GO:0035690","count":3}]},{"hash":"1864347223414699037","title":"RNA transcription and processing machinery","description":"This cluster shows a clear signal for gene expression and RNA maturation: transcription by RNA polymerase II and III, mRNA splicing, and ribosome biogenesis are prominent among the top terms, suggesting coordinated RNA synthesis and processing. Some other terms may be broader or incidental annotations, but the core theme is RNA transcription and processing.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0009636","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007584","count":3}]},{"hash":"324451432000833484","title":"Ion transporters and developmental regulators (worm-centric)","description":"The strongest signals are membrane ion transport (calcium, manganese, potassium) and physiological control (heart rate, pharyngeal pumping), pointing to a cluster of ion-channel or transporter proteins involved in neuromuscular function. Some GO terms refer to developmental processes (molting, axis specification, embryogenesis), suggesting additional roles in development. Overall, the unifying theme appears to be ion transport with neuromuscular/developmental associations.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":3},{"id":"GO:0006828","count":3},{"id":"GO:0002027","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0043050","count":2}]},{"hash":"282012104126156753","title":"Embryonic development and tissue morphogenesis","description":"The proteins cluster around developmental and morphogenetic processes, including placenta/trophoblast differentiation, left-right patterning, cartilage morphogenesis, and endocrine development, with additional emphasis on transcriptional regulation. This suggests a broad embryonic-development module rather than a single tissue-specific function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0060707","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5}]},{"hash":"1308864706566031337","title":"Host invasion and glycosphingolipid biosynthesis","description":"Based on the top GO terms, several proteins are linked to host cell entry by symbionts and formation of infection structures, plus biochemical pathways for glycosylation and glycosphingolipid (globoside) biosynthesis and cell wall organization. The cluster therefore appears to group invasion-related processes and membrane/glycan assembly, justifying a label around host invasion and lipid/glycan biosynthesis.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0046718","count":3},{"id":"GO:0006486","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0006011","count":2}]},{"hash":"1322067279684617641","title":"Blood coagulation and fibrinolysis regulation","description":"Based on the top GO terms, the cluster centers on proteolytic control in the blood and vascular remodeling: coagulation, regulation of angiotensin levels, bradykinin catabolism, and negative regulation of plasminogen activation and fibrinolysis. The presence of deglutamylation terms may reflect regulation of proteases/modulators by post-translational modifications, and liver regeneration points to hepatic factors involved in coagulation. Together, these terms suggest a coherent theme of vascular proteolysis regulation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007596","count":7},{"id":"GO:0002002","count":7},{"id":"GO:0010815","count":7},{"id":"GO:0003331","count":7},{"id":"GO:0051918","count":7}]},{"hash":"486425053362393870","title":"Neural development with inflammatory signaling","description":"The top terms include neural development processes (axonal fasciculation, myelination, positive regulation of synapse assembly) alongside immune/inflammatory terms (inflammatory response, innate immune response, cellular response to lipopolysaccharide). This suggests the cluster may coordinate neural development with inflammatory signaling pathways, though the presence of diverse morphogenesis terms indicates some heterogeneity. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":3},{"id":"GO:0072224","count":3},{"id":"GO:0060427","count":3},{"id":"GO:0060658","count":3},{"id":"GO:0042552","count":3}]},{"hash":"444502862168470125","title":"Inflammation and coagulation","description":"The cluster\u2019s top GO terms are dominated by immune/inflammatory processes (leukocyte migration in inflammatory response, fractalkine production, complement activation) along with coagulation and fibrinolysis regulation. While there are some transcription regulation and development terms, the core signal points to inflammatory/immune signaling and coagulation pathways.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":22},{"id":"GO:0030901","count":20},{"id":"GO:0030194","count":19},{"id":"GO:0031214","count":19},{"id":"GO:0045944","count":19}]},{"hash":"2035453718508576520","title":"Growth signaling and RNA processing","description":"This cluster centers on terms related to organismal growth (multicellular growth), TORC1 signaling, and ciliogenesis, with accompanying RNA processing (mRNA transport/splicing) implications. While a few terms (e.g., defense response) are outliers, the dominant theme is growth signaling and regulation of gene expression, justifying a label around growth signaling and RNA processing.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":12},{"id":"GO:0050830","count":12},{"id":"GO:0043547","count":10},{"id":"GO:0060271","count":9},{"id":"GO:0051028","count":9}]},{"hash":"1473838983293314630","title":"Adaptive immune receptor signaling","description":"The cluster is enriched for adaptive immune terms: high counts for adaptive immune response, T cell receptor signaling, and regulation of B cell receptor signaling, along with activated T cell proliferation and ERK/MAPK pathway regulation. These point to a cohesive network of receptor-mediated immune activation in lymphocytes, with protein dephosphorylation supporting signaling control. Angiogenesis-related terms appear but likely reflect inflammatory context rather than core function; the dominant theme is adaptive immune receptor signaling and activation.","confidence":"High","size":27,"edges":9,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":19},{"id":"GO:0070374","count":15},{"id":"GO:0002250","count":15},{"id":"GO:0043536","count":15},{"id":"GO:0001525","count":15}]},{"hash":"172657433276457774","title":"Nuclear transport and cytoskeleton regulation","description":"The cluster is dominated by terms for intracellular transport and localization, such as NLS-bearing protein import into the nucleus and localization to the cortical microtubule cytoskeleton, complemented by GTPase signaling and cell migration. While there are some cardiac-physiology terms, the strongest common themes are nuclear transport and cytoskeletal dynamics, with additional hints of development-related processes. ","confidence":"Medium","size":27,"edges":54,"triangles":48,"max_degree":16,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":12},{"id":"GO:0043547","count":11},{"id":"GO:0006607","count":11},{"id":"GO:0016477","count":10},{"id":"GO:0010909","count":9}]},{"hash":"1457954892250033784","title":"Cytoskeleton dynamics and mitosis with mechanosensing","description":"The top terms center on microtubule nucleation, spindle pole body duplication, mitotic cytokinesis, and division-site positioning, all pointing to cytoskeletal and mitotic machinery. Additional terms about neuron differentiation and mechanosensory behavior suggest an added link to mechanosensory signaling, but the core theme is cytoskeletal dynamics driving cell division, with a secondary mechanosensation aspect.","confidence":"Medium","size":27,"edges":42,"triangles":94,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030182","count":10},{"id":"GO:0007020","count":8},{"id":"GO:0090529","count":8},{"id":"GO:1905789","count":8},{"id":"GO:0007049","count":8}]},{"hash":"792907780678191517","title":"Organellar translation and ribosome biogenesis","description":"The cluster is dominated by GO terms related to translation (including mitochondrial translation) and ribosome biogenesis, plus maturation of SSU-rRNA, which together point to protein synthesis and ribosome assembly within organelles. The presence of a photosynthesis-related term suggests plastid involvement, reinforcing a focus on organellar (mitochondrial/chloroplast) ribosome function and translation.","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0032543","count":2},{"id":"GO:0019684","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0009052","count":1}]},{"hash":"484039630588094571","title":"Cell fate and growth signaling","description":"This cluster is dominated by terms related to signaling pathways that control cell fate, growth, and survival, notably canonical Wnt and Hippo signaling, plus processes like apoptosis, keratinocyte differentiation, centrosome cycle, and T cell receptor signaling. The gathered terms suggest a cohesive theme of signaling networks that regulate proliferation, differentiation, and cell survival across multiple cell types, so the label reflects the overarching function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090263","count":20},{"id":"GO:0006915","count":19},{"id":"GO:0030216","count":19},{"id":"GO:0060044","count":19},{"id":"GO:0035329","count":19}]},{"hash":"2088163151169589685","title":"Unknown","description":"The Top Terms span several unrelated processes (transcriptional regulation, xenobiotic response, angiogenesis, Rho signaling, yeast response, Gram-positive defense, growth, plasminogen activation, transport). With no dominant shared function and no observed edges, there is no clear, cohesive theme for the cluster.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0035690","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0045944","count":3}]},{"hash":"467138488379584541","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by translation and ribosome-related processes (translation; cytoplasmic translation; ribosome biogenesis; ribosomal subunit biogenesis and export), indicating a cluster enriched for ribosome assembly and protein synthesis machinery. There are a few ancillary terms (cell division, transcription, DNA repair), but the core signal points to ribosome biogenesis and translation as the defining theme.","confidence":"High","size":27,"edges":55,"triangles":107,"max_degree":16,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":6},{"id":"GO:0000747","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042273","count":4}]},{"hash":"881910708986737097","title":"Neural synaptic signaling and behavior","description":"The cluster centers on neuronal communication and behavior, with GO terms such as social behavior, vocalization behavior, neurotransmitter secretion, axon guidance, and positive regulation of synaptic transmission (glutamatergic), as well as regulation of synapse assembly and excitatory postsynaptic potentials. These collectively point to proteins involved in synapse formation and function that influence neural signaling and behavioral outputs. Some peripheral terms (e.g., blood pressure regulation, mitochondrial terms) may reflect ancillary roles or broad cellular processes but do not override the central neural theme.","confidence":"High","size":27,"edges":28,"triangles":0,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":4},{"id":"GO:2000463","count":2},{"id":"GO:0007269","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0051968","count":2}]},{"hash":"280981560887922399","title":"Cholesterol metabolism and nutrient-response regulation","description":"The cluster\u2019s strongest signals are cholesterol homeostasis, cholesterol efflux, and intestinal cholesterol absorption, pointing to a lipid metabolism theme. Additional terms for DNA-templated transcription, histone methylation, translation reinitiation, and ER-to-Golgi transport suggest coordinated gene expression and protein processing in response to nutrient status, with some peripheral links to broader metabolic or stress responses (e.g., antibiotic response, ommochrome biosynthesis). Overall, the data imply a core of lipid metabolism coupled to regulatory and trafficking processes.","confidence":"Medium","size":27,"edges":39,"triangles":6,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007584","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0051567","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0042632","count":4}]},{"hash":"324997445707709387","title":"Embryonic Organogenesis and Transcription Regulation","description":"The cluster shows strong enrichment for transcription-related GO terms (negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II) alongside diverse embryonic development terms across multiple organs (pituitary, endocrine pancreas, retina/eye, neural crest, osteoblasts, digestive tract). This points to proteins involved in developmental transcriptional control affecting several organ systems, rather than a single tissue-specific pathway.","confidence":"Medium","size":27,"edges":79,"triangles":35,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0006366","count":11},{"id":"GO:0021983","count":11},{"id":"GO:0031018","count":9},{"id":"GO:0002087","count":9}]},{"hash":"784801098716031114","title":"Innate immune signaling and actin cytoskeleton regulation","description":"The prominent GO terms include innate immune response, interferon signaling, and several cytoskeleton-related processes (actin filament polymerization, dendritic spine morphogenesis) plus negative regulation of small GTPases, which together point to a module that coordinates immune signaling with cytoskeletal remodeling. A few non-core terms (heart development, carbon fixation) are likely annotations from multi-functional proteins and do not override the central theme.","confidence":"High","size":27,"edges":31,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0060997","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0034260","count":2},{"id":"GO:0010923","count":2}]},{"hash":"1121350634609362437","title":"Nuclear import and pore assembly proteins","description":"The top GO terms strongly point to nuclear localization and transport (NLS-bearing and ribosomal protein import, nuclear pore complex assembly), suggesting a cluster of proteins involved in nuclear transport and pore function. Additional related terms (meiotic cohesion, protein regulation) support a broader nuclear-centric theme, though they are less central.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006607","count":3},{"id":"GO:0000060","count":3},{"id":"GO:0060188","count":3},{"id":"GO:0042176","count":3}]},{"hash":"1952173688060027145","title":"NF-kappaB-Driven Inflammatory Signaling","description":"This cluster shows strong enrichment for inflammatory and immune signaling terms: cellular response to interleukin-1, interleukin-8 production, apoptotic processes, and activation of NF-kappaB-inducing kinase, all pointing to NF-kappaB\u2013mediated inflammatory responses. Fibrinolysis and mechanical-stimulus response suggest downstream remodeling and stress reactions common to inflammation. While there are a few terms related to chitin/cuticle development and lung development, these are less central to the dominant inflammatory theme. Overall, the cluster appears to reflect NF-kappaB\u2013driven inflammatory signaling with associated remodeling processes.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":8},{"id":"GO:0042730","count":7},{"id":"GO:0006915","count":6},{"id":"GO:0007250","count":6},{"id":"GO:0072606","count":5}]},{"hash":"2174464338923157855","title":"Carbohydrate and secondary metabolite biosynthesis","description":"The top GO terms point to diverse biosynthetic processes, including polysaccharide and sugar metabolism (galactose, GDP-mannose, lipopolysaccharide, colanic acid), polyhydroxybutyrate biosynthesis, antibiotic biosynthesis, and plant secondary metabolite pathways (anthocyanin-containing compounds, phenylpropanoids). This suggests a unifying theme of biosynthesis across varied metabolite classes rather than a single pathway, spanning microbial and plant contexts.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0042619","count":8},{"id":"GO:0006012","count":7},{"id":"GO:0017000","count":6},{"id":"GO:0009103","count":6}]},{"hash":"87766782272961580","title":"Unknown","description":"The top GO terms are highly diverse (pheromone detection, angiogenesis regulation, fibrinolysis/plasminogen activation, lectin pathway complement activation, lipid and phospholipid metabolism, and mitochondrial processes) with no clear, common biological theme or shared pathway linking the proteins. The absence of edges and a coherent function across terms supports labeling this cluster as Unknown.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":5},{"id":"GO:0045766","count":2},{"id":"GO:0042730","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0001867","count":2}]},{"hash":"738028904138335317","title":"Embryonic Organ Morphogenesis","description":"The cluster\u2019s top GO terms are dominated by embryonic development and morphogenesis across multiple organs (pancreas, palate, forelimb, inner ear, cranial skeleton, gonads), suggesting a shared role in embryonic organogenesis, with a few unrelated terms present but not overriding the main signal.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":3},{"id":"GO:0050832","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060021","count":2}]},{"hash":"1356595357018513855","title":"Adaptive immune signaling and cell adhesion","description":"Based on the Top Terms, the proteins are enriched for adaptive and innate immune responses, including B cell receptor signaling (GO:0050853), IL-2 production, and integrin-mediated signaling (GO:0007229), as well as general immune response and cell adhesion. This points to a cluster of proteins involved in immune activation and cell\u2013cell or cell\u2013matrix interactions, i.e., signaling and adhesion in immune contexts. Some terms like subtelomeric heterochromatin formation and vasoconstriction are less aligned, but the dominant pattern is immune signaling and adhesion.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002250","count":8},{"id":"GO:0045087","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0045907","count":6},{"id":"GO:0051968","count":6}]},{"hash":"543990276894938645","title":"Rho/Ras GTPase signaling and actin remodeling","description":"This cluster is enriched for GO terms centered on small GTPase signaling (Rho, Ras, GTPase activity), actin filament organization, and endocytosis, pointing to proteins involved in cytoskeletal dynamics and vesicle trafficking. While also containing terms related to apoptosis and immune processes, the strongest, most coherent theme ties to regulation of GTPase-driven cytoskeleton remodeling and membrane trafficking.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0046580","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0007015","count":3}]},{"hash":"1810966270436031870","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006313","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0007469","count":2},{"id":"GO:0045316","count":2}]},{"hash":"1203524770475665109","title":"Retroviral integration and latency","description":"The top GO terms center on reverse transcription and genome integration (RNA-templated DNA biosynthetic process, DNA integration, DNA recombination) and on proviral latency and viral entry into host components, which together map to the retroviral life cycle and how viruses integrate into host genomes and establish latency. Some terms about symbiont entry and host apoptosis further support a virus\u2013host interaction theme, while a few unrelated terms (e.g., cell wall organization) are less specific. Overall, the cluster appears to reflect retroviral replication and latency processes.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0071555","count":4},{"id":"GO:1903704","count":4},{"id":"GO:0046718","count":4}]},{"hash":"72738819027335969","title":"Retroviral integration and latency","description":"The top GO terms point to DNA metabolism (replication, recombination, integration, RNA-templated DNA synthesis) and key retroviral life-cycle steps (proviral latency, viral entry into host, genome integration). Additional terms about host response and RNAi regulation fit with host\u2013virus interactions. Together, they support a theme centered on retroviral DNA integration and latency mechanisms.","confidence":"High","size":26,"edges":83,"triangles":138,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0006310","count":8},{"id":"GO:0015074","count":8},{"id":"GO:0042493","count":6},{"id":"GO:1903704","count":6}]},{"hash":"1617461962396341440","title":"Neural development and synaptic signaling","description":"The cluster is dominated by GO terms related to neural function: visual perception, long-term synaptic potentiation, axonogenesis, excitatory postsynaptic potential, and Schwann cell development, suggesting a theme around neural development, synaptic plasticity, and glial involvement. Some terms like mitotic cell cycle and abscisic acid signaling appear less consistent with neural specificity and may reflect cross-annotations, but the core pattern supports a neural development/synaptic function interpretation.","confidence":"Medium","size":26,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":13},{"id":"GO:0060291","count":13},{"id":"GO:0014044","count":12},{"id":"GO:0000086","count":12},{"id":"GO:0010800","count":12}]},{"hash":"1585812840440135112","title":"Hormone and Xenobiotic Metabolism","description":"This cluster centers on steroid hormone biosynthesis/metabolism (testosterone, androgens) and xenobiotic-related pathways (isoquinoline alkaloid metabolism, dibenzo-p-dioxin catabolic process), along with related retinoid/vitamin D and prostaglandin metabolism. The inclusion of stress response and cell-cycle regulatory terms suggests a broader hormonal/metabolic regulatory theme affecting signaling and proliferation, rather than a single, tight pathway. Overall, it best represents hormone and xenobiotic metabolic processing with ancillary regulatory signals.","confidence":"Medium","size":26,"edges":4,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":18},{"id":"GO:0008209","count":18},{"id":"GO:0033076","count":17},{"id":"GO:0033280","count":17},{"id":"GO:0001516","count":17}]},{"hash":"2376325913290999","title":"Vitamin biosynthesis and nucleotide salvage","description":"The top GO terms cluster around vitamin biosynthesis (menaquinone, cobalamin) and salvage pathways (nicotinate nucleotide/NAD salvage), plus nucleotide catabolic processes, indicating a group of proteins involved in vitamin and nucleotide metabolism rather than a single signaling or transport function. Some unrelated terms may reflect broad annotations, but the dominant theme is metabolic biosynthesis and salvage of vitamins and nucleotides.","confidence":"High","size":26,"edges":67,"triangles":65,"max_degree":15,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009234","count":6},{"id":"GO:0019358","count":6},{"id":"GO:0034356","count":5},{"id":"GO:0006218","count":5},{"id":"GO:0009236","count":4}]},{"hash":"748276062859566830","title":"Blood Coagulation and Fibrinolysis","description":"The cluster is driven by GO terms tied to fibrinolysis, plasminogen activation, and blood coagulation (with negative regulation terms), plus complement activation, indicating a core theme of hemostasis and immune-related vascular remodeling. The presence of angiogenesis regulation and in utero embryonic development terms suggests this set also relates to vascular development and remodeling in a developmental context. Overall, the proteins appear to function predominantly in coagulation/fibrinolysis with links to vascular growth.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":6},{"id":"GO:0045766","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0071333","count":5},{"id":"GO:0006958","count":4}]},{"hash":"1355351523420763523","title":"Unknown","description":"These terms span development (face morphogenesis, metamorphosis, prostate gland development, male sex differentiation), steroid signaling (steroid hormone receptor complex assembly), immune response (cellular response to type I interferon), RNA processing (box C/D snoRNP assembly), and protein quality control (ERAD pathway). They do not point to a single, shared function or pathway for the cluster, so a coherent, intuitive label is not possible. ","confidence":"","size":26,"edges":187,"triangles":674,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0042264","count":6},{"id":"GO:0071357","count":6},{"id":"GO:0060325","count":6},{"id":"GO:0006463","count":6},{"id":"GO:0030850","count":6}]},{"hash":"953247059237544096","title":"Embryonic morphogenesis across tissues","description":"This cluster is enriched for diverse development and morphogenesis terms spanning multiple organs (gonadal, mammary, prostate, brain habenula, eye, hindlimb) and includes transcriptional regulation and estrogen signaling, pointing to broad embryonic development programs rather than a single tissue-specific function.","confidence":"Medium","size":26,"edges":101,"triangles":73,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033327","count":13},{"id":"GO:0006351","count":13},{"id":"GO:0060749","count":13},{"id":"GO:0021986","count":11},{"id":"GO:2000288","count":11}]},{"hash":"1245888163681704790","title":"Mitochondrial Energy Metabolism and Ion Transport","description":"The cluster shows enrichment for mitochondrial-related processes: proton motive force\u2013driven ATP synthesis and protein import into the mitochondrial matrix, along with monoatomic cation transmembrane transport and voltage-gated calcium channel activity, indicating ion handling tied to mitochondrial energetics. While there are a few unrelated terms (e.g., heart morphogenesis, xenobiotic response), the dominant theme ties to mitochondrial energy production and ion homeostasis.","confidence":"Medium","size":26,"edges":288,"triangles":2056,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0099132","count":3},{"id":"GO:0015986","count":2},{"id":"GO:0001300","count":2},{"id":"GO:1901387","count":2},{"id":"GO:0035690","count":2}]},{"hash":"1004126882843544038","title":"Ribosome biogenesis and rRNA processing","description":"The top terms cluster around large subunit ribosome maturation, LSU rRNA processing, preribosome/LSU assembly, and nuclear export of the large subunit, classic indicators of ribosome biogenesis. Additional signals from mRNA decay and P-body assembly, plus transcription regulation, suggest this group participates in broader RNA metabolism as part of ribosome production. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0000466","count":2},{"id":"GO:1902626","count":2}]},{"hash":"2113380207462311444","title":"Cardiac Muscle Contraction and Morphogenesis","description":"The top GO terms point strongly to heart muscle biology, with cardiac muscle contraction, ventricular cardiac muscle tissue morphogenesis, and regulation of muscle filament sliding speed indicating a cardiac-focused cluster. Other terms (peroxisome organization, cone cell development, xenobiotic response, and IGF/TGF-beta signaling regulation) suggest additional, less cohesive functions among members, but the dominant theme remains cardiac muscle function and development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032581","count":2},{"id":"GO:0014883","count":2},{"id":"GO:0032972","count":2},{"id":"GO:0055010","count":2},{"id":"GO:0060048","count":2}]},{"hash":"2291203178496134285","title":"Neuronal axon guidance and projection","description":"The cluster is enriched for GO terms tied to axon guidance across multiple neuron types (branchiomotor, sympathetic, trigeminal), nerve projection guidance, and neural crest cell migration, with semaphorin-plexin signaling highlighted; some ion transport terms may reflect neuronal physiology rather than core function.","confidence":"High","size":26,"edges":25,"triangles":0,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0021785","count":4},{"id":"GO:1902287","count":4},{"id":"GO:0097491","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0036486","count":4}]},{"hash":"2124259992598871939","title":"Organogenesis signaling pathways","description":"_this cluster centers on multiple developmental signaling cascades (ROBO, Hedgehog/Smoothened, ERK/MAPK) and organ development processes, including nervous system, heart, kidney, and muscle formation, suggesting a coordinated role in organogenesis and tissue patterning._","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":10},{"id":"GO:0035385","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0070374","count":10},{"id":"GO:0007224","count":9}]},{"hash":"825228088256744040","title":"Synaptic signaling and receptor trafficking","description":"The cluster shows a strong enrichment for neuronal signaling processes: receptor clustering and internalization, regulation of synaptic vesicle fusion at the presynaptic zone, and modulation of sensory perception, which together point to dynamic receptor trafficking and synaptic transmission. Also, transmembrane transport of sodium and potassium aligns with ion flux critical for synaptic activity. Some GO terms like multicellular organism growth and male gonad development are broader or less directly connected, suggesting possible multifunction annotations. Overall, the dominant theme is synaptic communication and receptor dynamics, with a few outliers.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0007338","count":3}]},{"hash":"1338642160674282897","title":"Inflammation, immune defense, and coagulation","description":"The top GO terms cluster around inflammatory processes and immune defense (leukocyte migration in inflammatory response, defense response to Gram-positive bacteria, fractalkine production, complement activation) and hemostasis (blood coagulation, positive regulation of fibrinolysis). These point to a coherent theme of immune activation paired with coagulation and tissue remodeling (collagen catabolic process). Some terms like midbrain development and transcriptional regulation are outliers, but the dominant signal supports an inflammation/coagulation-centric function. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":10},{"id":"GO:0007596","count":9},{"id":"GO:0051919","count":9},{"id":"GO:0002523","count":9}]},{"hash":"350236115484077578","title":"Nervous System Development and Immune Signaling","description":"The top GO terms cluster around neural development (myelination, axonal fasciculation, synapse assembly) with supporting processes in mechanosensation and sensory system formation, plus extracellular matrix organization (collagen fibril) and immune functions (innate and adaptive). While the terms are diverse, the common thread appears to be proteins involved in nervous system development/maintenance with accompanying immune-related roles, rather than a single, tight pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0030199","count":2}]},{"hash":"1997565361040175245","title":"Innate immune defense and coagulation with ECM remodeling","description":"The top GO terms point to innate immune responses (defense against Gram-positive bacteria and fungi, response to yeast), along with complement activation and leukocyte recruitment. Coagulation and extracellular matrix remodeling terms (blood coagulation, elastin catabolic process, cell-matrix adhesion) suggest coordinated inflammatory and tissue-remodeling activity. The negative regulation of transcription by RNA polymerase II is less specific here, so the core theme is inflammatory defense coupled with ECM changes.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0050830","count":13},{"id":"GO:0006958","count":13},{"id":"GO:0014068","count":13},{"id":"GO:0007596","count":12}]},{"hash":"369000468234397279","title":"Unknown","description":"The GO terms span diverse processes\u2014Wnt signaling, angiogenesis, extracellular proteolysis (fibrinolysis, plasminogen activation), immune complement activation, pigment biosynthesis, transport, and cell-surface localization\u2014giving no single cohesive function for the cluster.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0034394","count":2},{"id":"GO:0070328","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0042730","count":2}]},{"hash":"25298321789022427","title":"Unknown","description":"The top GO terms are highly diverse, spanning viral release, RNA editing, immune/hematopoietic development, inositol phosphate and phosphatidylinositol biosynthesis, neural development, and even plant pollen processes, with no clear shared function or pathway and no interactions among proteins. This makes it impossible to assign a cohesive, specific function name.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":3},{"id":"GO:0006382","count":2},{"id":"GO:0035726","count":2},{"id":"GO:0032958","count":2},{"id":"GO:0001841","count":2}]},{"hash":"917593438015658175","title":"Embryonic Development and Gene Regulation","description":"This cluster is dominated by developmental processes (pituitary gland development, cerebellum formation, ureteric bud branching morphogenesis, multicellular organism development) and gene-expression control (alternative splicing, miRNA-mediated silencing, ERK signaling). While cholesterol metabolism and lipopolysaccharide response are present, the strongest signal points to developmental signaling and post-transcriptional regulation shaping tissue formation and differentiation.","confidence":"Medium","size":25,"edges":35,"triangles":11,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0008203","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0007568","count":2}]},{"hash":"2171177956829785278","title":"Vascular signaling and blood pressure regulation","description":"Most terms describe signaling and processes that control vascular tone and cardiovascular function: GPCR-mediated cAMP signaling and adenylate cyclase activation, prostaglandin response, endothelial barrier regulation, and smooth muscle contraction, plus blood coagulation. The presence of blood pressure regulation and prostaglandin-related signals supports a vascular/cardiovascular theme, with circadian rhythm as a modulatory layer. A minority term for energy metabolism (electron transport chain) is present but does not override the central vascular-focused pattern.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":24},{"id":"GO:0010579","count":24},{"id":"GO:0022900","count":24},{"id":"GO:0007190","count":23},{"id":"GO:0046960","count":21}]},{"hash":"1331239211395431426","title":"RNA processing and translation initiation regulation","description":"This cluster is strongly enriched for translation initiation terms (translation reinitiation, preinitiation complex formation, IRES-dependent viral translation, regulation of translational initiation), indicating a core role in initiating and controlling protein synthesis. The presence of mRNA splicing and ncRNA-mediated silencing terms suggests these proteins also participate in broader RNA metabolism and post-transcriptional regulation, tying RNA processing to translation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":15},{"id":"GO:0001731","count":15},{"id":"GO:0075525","count":10},{"id":"GO:0006446","count":10},{"id":"GO:0075522","count":10}]},{"hash":"538888463008467729","title":"Spliceosome-mediated mRNA splicing","description":"The top GO terms are dominated by spliceosome- and mRNA splicing-related processes (cis-splicing, spliceosome conformational changes, and general mRNA splicing), with additional mRNA processing terms, indicating a cohesive role in the RNA splicing machinery.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001825","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0010226","count":2},{"id":"GO:0000388","count":2}]},{"hash":"1062261259989347546","title":"Innate Immune Signaling and Cytokine Production","description":"The cluster is dominated by innate immune and host defense terms, including defense response to Gram-positive bacteria, defense response to virus, lipopolysaccharide-mediated signaling, innate immune response, and positive regulation of IL-8 production, indicating a coherent role in immune signaling and inflammatory responses. Some axon guidance terms appear, likely reflecting shared signaling components rather than defining the cluster\u2019s primary function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0007413","count":5},{"id":"GO:0007169","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0014068","count":5}]},{"hash":"679255441567902509","title":"Regulated signaling and mitotic control","description":"This cluster centers on GO terms reflecting regulation of signaling pathways and phosphorylation (protein serine/threonine kinase activity, GTPase activity, NFAT signaling) and mitotic cell cycle, with an additional emphasis on hypoxia response and broader regulatory roles like mRNA transport and retina development. The shared theme appears to be signaling-driven control of cell proliferation and cell-cycle progression, making this a cohesive functional module despite some outlier terms. ","confidence":"Medium","size":25,"edges":11,"triangles":0,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1907316254082078388","title":"Embryonic tissue and organ morphogenesis","description":"These proteins' GO annotations cluster around developmental processes and morphogenesis across multiple tissues, especially embryonic stages and craniofacial, neural, muscular, pancreatic, and uterine development. The common theme is embryonic tissue formation rather than a single tissue-specific pathway, supporting a cohesive label of embryonic tissue and organ morphogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030901","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0003148","count":6},{"id":"GO:0007519","count":5},{"id":"GO:0051216","count":5}]},{"hash":"1561125969980340781","title":"Immune System Homeostasis and NF-kappaB Signaling","description":"The cluster is dominated by immune-related functions: T and B cell homeostasis, innate immune response, defense against virus, spleen development, and both canonical NF-kappaB signaling and ubiquitin-dependent protein catabolic processes, which together point to regulation and maintenance of immune responses via NF-kappaB pathways. Some metabolic terms appear incidental, but the overarching theme is immune system regulation and signaling. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0043029","count":4},{"id":"GO:0009103","count":4},{"id":"GO:0006012","count":4},{"id":"GO:0051092","count":4}]},{"hash":"2005277467934162676","title":"Potassium Transport and Membrane Potential Regulation","description":"Based on the top GO terms, the proteins are enriched for potassium ion transport, regulation of resting membrane potential, stabilization of membrane potential, intracellular potassium homeostasis, and neuronal action potential. These indicate a cluster centered on ion channels/transporters that control cellular excitability in neurons and cardiac cells, with a note of neuroendocrine signaling via vasopressin secretion. Therefore, the label reflects the shared function of potassium-mediated membrane potential regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050976","count":4},{"id":"GO:0030322","count":4},{"id":"GO:0030007","count":4},{"id":"GO:0060075","count":4},{"id":"GO:0098914","count":4}]},{"hash":"283771017713075336","title":"Unknown","description":"The 25 proteins display a broad and disparate mix of GO terms\u2014immune signaling, RNA processing, and various developmental and plant-specific processes\u2014without a unifying function or pathway, and with no reported interactions, so there is no coherent theme to label beyond Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0048294","count":2},{"id":"GO:0009958","count":2},{"id":"GO:0042092","count":2}]},{"hash":"2292187238695701340","title":"Unknown","description":"The GO terms are dispersed across neural differentiation, signaling, endocrine secretion, cardiac electrophysiology, liver apoptosis, and general multicellular processes, with no clear shared pathway or cohesive function given the lack of edges/connectivity; thus no single theme emerges to label the cluster meaningfully.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":5},{"id":"GO:0033280","count":5},{"id":"GO:0016055","count":5},{"id":"GO:0070213","count":4},{"id":"GO:1904908","count":4}]},{"hash":"602397509082237463","title":"Inflammation, Coagulation, and Tissue Remodeling","description":"The top GO terms cluster around innate immune defense and coagulation (blood coagulation, fibrinolysis regulation, complement activation, leukocyte migration, defense against Gram-positive bacteria), along with extracellular matrix remodeling (collagen catabolic process) and vascular changes (angiogenesis). This combination suggests a module where inflammatory responses, hemostasis, and tissue remodeling are coordinated.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":14},{"id":"GO:0051919","count":14},{"id":"GO:0002523","count":14},{"id":"GO:0050754","count":14},{"id":"GO:0006958","count":14}]},{"hash":"854636324601456400","title":"TLR/MyD88-Driven Inflammatory Signaling","description":"The terms are centered on innate immune recognition of bacteria, especially MyD88-dependent Toll-like receptor signaling, detection of LPS, and cellular responses leading to cytokine production (TNF, IL-6) and NLRP3 inflammasome regulation, indicating a cohesive theme of bacterial sensing and inflammatory signaling. A single outlier term related to floral meristem growth appears incidental rather than representative of the cluster\u2019s main function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002755","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0032497","count":3},{"id":"GO:0071222","count":3},{"id":"GO:1900227","count":3}]},{"hash":"603270991122351690","title":"Neuro-immune regulation of synaptic activity","description":"The GO terms show a mix of innate immune and T cell signaling alongside neural synaptic terms (AMPA receptor activity, glutamatergic transmission, excitatory postsynaptic potential) and even vocalization behavior, pointing to a cluster of proteins involved in neural communication modulated by immune signaling. While there are broader roles (e.g., TGF-beta signaling, bone development), the cohesive theme centers on cross-talk between immune pathways and excitatory synaptic modulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0071625","count":3},{"id":"GO:2000463","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0051968","count":3}]},{"hash":"1201873769968643830","title":"Coagulation and Inflammatory Signaling","description":"The top GO terms cluster around blood coagulation (positive regulation and general), fibrinolysis, leukocyte migration in inflammatory response, complement activation, fractalkine production, and interleukin-8 regulation. Together these indicate a coherent theme of coagulation processes intertwined with inflammatory/immune signaling, with other terms like biomineral tissue development and midbrain development likely reflecting multifunctional roles of the proteins rather than a single pathway. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030194","count":12},{"id":"GO:0031214","count":12},{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":11},{"id":"GO:0007596","count":10}]},{"hash":"728665124116118149","title":"Metanephric nephron development","description":"The Top Terms show multiple kidney developmental processes (ascending limb, thick limb, distal convoluted tubule development) along with related morphogenic activities (cell-matrix adhesion, cell migration in heart development, transcription), suggesting the cluster centers on metanephric nephron formation and associated morphogenesis, with some supporting regulatory roles.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097211","count":3},{"id":"GO:0042102","count":2},{"id":"GO:0072218","count":2},{"id":"GO:0072233","count":2},{"id":"GO:0007160","count":2}]},{"hash":"2240621099678569840","title":"Developmental Regulation and Signaling","description":"The GO terms point to regulation of development across multiple tissues (blastocyst, adrenal gland, mammary gland, bone) along with general regulatory processes (calcium signaling, transcriptional regulation, and protein dephosphorylation). The spread suggests a theme of controlling developmental programs via signaling and regulatory pathways rather than a single, cohesive process.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001824","count":3},{"id":"GO:2000678","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0006470","count":3},{"id":"GO:1900271","count":3}]},{"hash":"813489730634813693","title":"Cardiac electrophysiology and potassium transport","description":"The cluster is dominated by GO terms related to cardiac electrical activity and ion handling, including regulation of heart rate via conduction, atrial and AV node action potentials, membrane depolarization/repolarization, and potassium ion transport across the membrane. While a couple of terms (ossification, touch detection) are less directly related, the core theme points to cardiac electrophysiology and ionic control, especially potassium flux, as the cohesive function of this cluster.","confidence":"Medium","size":24,"edges":9,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0086091","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0098914","count":7},{"id":"GO:0043931","count":7},{"id":"GO:0050976","count":6}]},{"hash":"852405714124496137","title":"Unknown","description":"The top GO terms span diverse and largely unrelated biology (amino acid biosynthesis regulation, redox, apoptotic cell recognition, coagulation, plant phenylpropanoid metabolism, bacterial lipoteichoic acid biosynthesis, fatty acid transport/import, and seed development). This heterogeneity provides no single, coherent function or theme to name the cluster, and several terms are obsolete, so a precise label is not justifiable.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":7},{"id":"GO:0055114","count":6},{"id":"GO:0043654","count":5},{"id":"GO:0072378","count":5},{"id":"GO:0009698","count":5}]},{"hash":"2085422408944804523","title":"Chromatin modification and histone acetylation","description":"The cluster is dominated by terms related to heterochromatin formation and histone acetylation, including multiple N-terminal acetylation events, suggesting a shared role in chromatin regulation and epigenetic modification; metabolism terms are present but secondary.","confidence":"High","size":24,"edges":43,"triangles":18,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":17},{"id":"GO:0061606","count":16},{"id":"GO:0043967","count":16},{"id":"GO:0006041","count":16},{"id":"GO:0017198","count":16}]},{"hash":"558888765293799884","title":"ER Stress and Energy Metabolism","description":"The cluster shows enrichment for ER unfolded protein response and stress-related transcription, along with protein import into peroxisomes, UV repair, and oxidation-dependent protein turnover. Energy metabolism terms (ATP biosynthesis, oxidative phosphorylation) indicate metabolic upregulation in response to stress. Taken together, these terms point to a cellular stress-adaptation program coordinated with energy production and protein quality control rather than a single, narrow function.","confidence":"Medium","size":24,"edges":53,"triangles":57,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030968","count":13},{"id":"GO:0051301","count":13},{"id":"GO:0006351","count":11},{"id":"GO:0016558","count":10},{"id":"GO:0030420","count":10}]},{"hash":"751636788464515343","title":"Plant Cell Wall Polysaccharide Biosynthesis and Glycosylation","description":"The cluster is strongly enriched for plant cell wall\u2013related processes: mucilage and various polysaccharide biosynthesis (homogalacturonan, glucuronoxylan, galactose metabolism), cell wall organization, and protein O-linked glycosylation. These terms together point to proteins involved in synthesizing and decorating cell wall polysaccharides, consistent with plant extracellular matrix formation and mucilage production.","confidence":"High","size":24,"edges":12,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":10},{"id":"GO:0010192","count":9},{"id":"GO:0043403","count":9},{"id":"GO:0009834","count":9},{"id":"GO:0035269","count":9}]},{"hash":"1137826706885160039","title":"Neural Development and Signaling Pathways","description":"The top GO terms include nervous system development, axon guidance, Roundabout signaling, and ERK/MAPK signaling, pointing to neural development and guidance processes. Additional terms (bone ossification, kidney and spermatid development, mast cell chemotaxis) suggest broader developmental signaling across tissues, but the neural development and guidance signals are the strongest cluster theme.","confidence":"Medium","size":24,"edges":118,"triangles":152,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":14},{"id":"GO:0035385","count":14},{"id":"GO:0070374","count":14},{"id":"GO:0043552","count":13},{"id":"GO:0007411","count":13}]},{"hash":"1605126341320729492","title":"Ubiquitin-mediated trafficking and turnover","description":"This cluster is dominated by GO terms tied to ubiquitination and membrane trafficking, including monoubiquitination, ubiquitin-dependent protein catabolic processes, ubiquitin-dependent endocytosis, and Golgi-to-plasma membrane transport. Together these point to a functional theme of protein processing, tagging, and trafficking within the cell. Some developmental terms (sperm axoneme assembly, hippocampus development, fat cell differentiation) appear as possible noise or multi-function annotations, but the core signal supports a role in ubiquitin-driven protein handling and trafficking.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007288","count":2},{"id":"GO:0043001","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0006513","count":2}]},{"hash":"941692490307364076","title":"Neurodevelopmental Signaling","description":"The dominant terms point to neural development and related signaling pathways: Hedgehog (Smoothened), Roundabout (ROBO), and axon guidance; plus nervous system development and axonogenesis. Additional terms (Rab signaling, vesicle trafficking, cell cycle) reflect broader signaling context, but the strongest signal is neural development and patterning, with multiple pathways converging on neural patterning.","confidence":"High","size":24,"edges":164,"triangles":496,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007224","count":16},{"id":"GO:0001822","count":15},{"id":"GO:0035385","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0050852","count":13}]},{"hash":"1447309354887656315","title":"Cell-cycle, developmental, and immune signaling","description":"The dominant GO terms point to core cellular processes (DNA replication, mitotic cell cycle) alongside diverse developmental processes (telencephalon development, neural tube closure, trachea formation). Immune signaling is also prominent (T cell receptor signaling pathway, activated T cell proliferation), suggesting the cluster comprises cells engaged in growth and differentiation with immune signaling. Some terms like cellular response to alkaline pH and response to cocaine indicate general stress responses but do not define a single pathway. Overall, the label captures the main themes of cell division, development across tissues, and immune-related signaling, making it a reasonable high-level category for this cluster.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042220","count":22},{"id":"GO:0006260","count":21},{"id":"GO:0000278","count":21},{"id":"GO:0020021","count":20},{"id":"GO:0060440","count":20}]},{"hash":"399400791701567789","title":"Transmembrane Nutrient and Xenobiotic Transporters","description":"The cluster is dominated by GO terms for transmembrane transport of diverse substrates: vitamin and xenobiotic transport, nitrate and potassium ion transport, and organic ion transport, plus nitrate assimilation. This pattern indicates a set of membrane transporter proteins specialized in moving nutrients, ions, and xenobiotics across membranes, with some involvement in host interactions noted by the older antibiotic transport term. Overall, a coherent theme of membrane transport functions across multiple substrates justifies the label.","confidence":"High","size":24,"edges":30,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":18},{"id":"GO:0006855","count":18},{"id":"GO:0042891","count":16},{"id":"GO:0042908","count":14},{"id":"GO:0071805","count":14}]},{"hash":"1822682711141560186","title":"Lung epithelial morphogenesis and polarity signaling","description":"The cluster centers on processes linked to epithelial growth and tissue architecture, highlighted by the strongest term: positive regulation of epithelial cell proliferation involved in lung morphogenesis. Additional enrichment for cell polarity establishment/maintenance and cytoskeleton-related remodeling supports a theme of epithelial shape and junction integrity. While other terms (e.g., insulin signaling, NF-kB regulation, general gene expression) suggest broader regulatory roles, the dominant signal points to lung epithelial morphogenesis and polarity control. Some terms (like odor perception) may reflect broader annotation rather than direct lung epithelial function, indicating some functional noise but not overriding the core theme.","confidence":"Medium","size":24,"edges":4,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060501","count":7},{"id":"GO:0055091","count":6},{"id":"GO:0010628","count":6},{"id":"GO:0090307","count":5},{"id":"GO:0043124","count":5}]},{"hash":"8581826470058234","title":"Lipid, pigment, and steroid biosynthesis","description":"The terms cluster around biosynthetic pathways for lipids (fatty acids, sphingolipids, very long-chain fatty acids), pigments (melanin), and steroids (estrogen) as well as retinol metabolism, suggesting a unifying theme of diverse lipid- and pigment-related biosynthesis, with some secondary metabolism notes (antibiotic-related processes) included. ","confidence":"High","size":24,"edges":21,"triangles":6,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0042619","count":8},{"id":"GO:0042572","count":7},{"id":"GO:0046677","count":7}]},{"hash":"426266955623710387","title":"Embryonic Development and Tissue Morphogenesis","description":"The GO terms cluster around broad developmental processes across multiple tissues\u2014placental differentiation, cartilage and pancreatic development, heart morphogenesis via EMT, left-right patterning, endocrine organ formation, and even T cell signaling\u2014pointing to a general theme of embryogenesis and tissue differentiation rather than a single pathway. No single cohesive pathway stands out due to diversity, but the shared thread is developmental morphogenesis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0048041","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2}]},{"hash":"1447884294617689196","title":"Redox Regulation of Inflammation and Growth","description":"The cluster is dominated by terms for redox balance and detoxification (cellular redox homeostasis; cellular oxidant detoxification), mitochondrial membrane potential regulation, and protein glutathionylation, which points to redox signaling and mitochondrial health. The presence of multiple terms describing negative regulation of inflammatory mediators (TNF, MCP-1, acute inflammatory response) indicates anti-inflammatory modulation, while terms like organ regeneration and growth regulation suggest a link to regenerative processes. Together, these features describe a coherent module centered on redox maintenance coordinated with anti-inflammatory signaling and growth/regeneration cues.","confidence":"High","size":24,"edges":275,"triangles":2002,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":21},{"id":"GO:0098869","count":21},{"id":"GO:0051881","count":20},{"id":"GO:0060316","count":20},{"id":"GO:0010731","count":20}]},{"hash":"1196981671795274170","title":"Immune Receptor Signaling and T/B Cell Activation","description":"Based on the top GO terms, the proteins are enriched for immune signaling activities: innate immune response, B cell receptor signaling, T cell costimulation, and tyrosine phosphorylation events, which together point to receptors and signaling cascades that regulate adaptive immune cell activation. While a few terms touch on broader processes like ephrin signaling and cell cycle, the strongest recurring theme is immune receptor\u2013mediated communication driving T and B cell activation, making this label specific and representative.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0050853","count":3},{"id":"GO:0048013","count":2},{"id":"GO:0031295","count":2},{"id":"GO:0000187","count":2}]},{"hash":"1506874825689530103","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms cluster around embryonic development and organ formation: placental/trophoblast differentiation, endocrine system development, pancreatic cell development, left-right patterning, cartilage morphogenesis, and EMT in heart cushion formation. While a couple of terms reflect general gene expression processes (splicing, ribosomal export), the dominant theme is embryogenesis and tissue morphogenesis, suggesting these proteins function together in developmental patterning and organogenesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":22},{"id":"GO:0060806","count":22},{"id":"GO:0035270","count":22},{"id":"GO:0060536","count":22},{"id":"GO:0060972","count":22}]},{"hash":"1945359881177581071","title":"Unknown","description":"The top terms span diverse processes (tissue development, Rab signaling, GTPase activation, host entry, DNA damage response, cell cycle) with no clear unifying function among all proteins, so a single cohesive label isn\u2019t supported.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048745","count":3},{"id":"GO:0070309","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0032483","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1227896118609810730","title":"Actin cytoskeleton remodeling and development signaling","description":"The cluster is rich in actin-related terms (Arp2/3-mediated nucleation, actin cortical patch assembly) and signaling regulation (GTPase activity, tyrosine phosphorylation) alongside development-related terms (multicellular organism development, skin development) and cell-cycle involvement (mitotic cell cycle). This suggests a shared function centered on actin dynamics coordinated with developmental signaling and division, despite auxiliary terms like hypoxia response and mRNA transport. ","confidence":"Medium","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000147","count":5},{"id":"GO:0071456","count":5},{"id":"GO:0051028","count":5},{"id":"GO:0050731","count":5},{"id":"GO:0043588","count":5}]},{"hash":"543748012100140748","title":"Mitotic spindle control and embryonic development","description":"The cluster shows strong signals for mitotic/spindle-related processes (establishment of mitotic spindle orientation, regulation of meiotic nuclear division, cell cycle checkpoint regulation, spindle pole body separation) alongside embryonic development terms (gastrulation, neural tube closure). Additional hints from chromatin-related processes (histone H3 acetylation, monoubiquitination) suggest broader regulation of gene expression during development. Together, these terms point to a cohesive theme of coordinating cell division mechanics with embryonic development.","confidence":"Medium","size":23,"edges":63,"triangles":89,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0040020","count":2},{"id":"GO:0001843","count":2}]},{"hash":"1204796046704881808","title":"RNA processing and ribosome biogenesis (nuclear & mitochondrial)","description":"The cluster is strongly enriched for RNA processing and splicing (mRNA splicing, exon ligation, spliceosome disassembly), mRNA quality control (nonsense-mediated decay), rRNA maturation, and mitochondrial ribosomal subunit assembly, pointing to a shared role in RNA maturation and ribosome assembly across nuclear and mitochondrial compartments. A few DNA replication-related terms appear incidental and do not define the core function.","confidence":"High","size":23,"edges":26,"triangles":18,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000184","count":11},{"id":"GO:0006268","count":10},{"id":"GO:0009432","count":10},{"id":"GO:0006306","count":10},{"id":"GO:0006269","count":10}]},{"hash":"2082406477967658304","title":"Vertebrate Development and Wnt Signaling","description":"The cluster is dominated by developmental and morphogenesis terms: Wnt signaling, embryonic cranial skeleton morphogenesis, and skeletal system development, plus neuron projection development and multicellular growth, suggesting a vertebrate developmental program. DNA replication and transcription by RNA polymerase II point to proliferative tissues associated with growth and development. Complement activation and defense response to Gram-positive bacteria appear as outliers, likely reflecting incidental immune-related roles rather than core function of the cluster. Overall, the cluster appears to reflect vertebrate developmental signaling, especially Wnt-driven growth and skeletal/neural morphogenesis.","confidence":"Medium","size":23,"edges":11,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0016055","count":5}]},{"hash":"1935136731386379394","title":"DNA replication and ribosome biogenesis","description":"The top GO terms cluster around DNA replication, DNA-templated transcription, translation, and ribosomal subunit biogenesis, including rRNA maturation, indicating a core theme of nucleic acid metabolism and protein synthesis. A couple of terms (fatty acid beta-oxidation and ER-to-Golgi transport) are less directly related and may reflect broader cellular processes or annotation noise. Overall, the dominant signal supports this label.","confidence":"Medium","size":23,"edges":49,"triangles":80,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0019079","count":2}]},{"hash":"2223636259187917527","title":"Neuronal Synaptic Signaling and Calcium Regulation","description":"The cluster\u2019s top GO terms cluster around neuronal communication (excitatory postsynaptic potential), dendrite morphogenesis, and calcium signaling (calcium detection, calcium-release channel regulation), plus regulatory signaling (NFAT) and brain development cues (substantia nigra development). A minority of terms involve immune complement activity, which can intersect with neural remodeling via calcium- and signaling-dependent processes. Overall, the proteins appear linked to neuron-to-neuron signaling and calcium-dependent regulatory pathways central to synaptic function and development.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":7},{"id":"GO:0050774","count":7},{"id":"GO:0001867","count":5},{"id":"GO:0060316","count":5},{"id":"GO:0007114","count":5}]},{"hash":"437649958564818057","title":"Steroid hormone and prostaglandin biosynthesis","description":"The Top Terms include testosterone biosynthetic process and androgen metabolic process, both steroid hormone pathways, along with prostaglandin biosynthetic process. Vitamin D response and lung development terms further support a steroid/lipid mediator\u2013driven signaling context. While there are additional cellular processes like DNA replication and vesicle trafficking present, the strongest shared theme across the cluster is lipid hormone and mediator biosynthesis (steroids and prostaglandins).","confidence":"Medium","size":23,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0061370","count":6},{"id":"GO:0008209","count":6},{"id":"GO:1900087","count":5},{"id":"GO:0030324","count":5},{"id":"GO:0046677","count":4}]},{"hash":"176327439636654556","title":"Neuronal endocytosis and vesicle trafficking","description":"The top terms cluster around endocytosis, actin-mediated patch assembly, Golgi-endosome transport, endosome sorting (including multivesicular body pathways), and regulation of synaptic vesicle exocytosis, all of which point to vesicle trafficking and membrane dynamics in neurons. While there is a single term about substantia nigra development, the prevailing signal is neuronal endocytic and vesicular transport processes.","confidence":"High","size":23,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0034260","count":3},{"id":"GO:0006895","count":2}]},{"hash":"2110621951388363262","title":"Embryonic development and T cell signaling cluster","description":"Dominated by GO terms for embryonic development (trachea formation, telencephalon development, neural tube closure) and adaptive immunity (T cell receptor signaling, activated T cell proliferation). This suggests a functional theme linking organogenesis with immune signaling, though other terms like ER stress\u2013induced apoptosis and pH response reflect broader cellular stress processes that accompany such pathways.","confidence":"Medium","size":23,"edges":201,"triangles":919,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0020021","count":23},{"id":"GO:0060440","count":23},{"id":"GO:0021537","count":23},{"id":"GO:0050852","count":23},{"id":"GO:0001843","count":23}]},{"hash":"211347497475618591","title":"Unknown","description":"The GO terms are diverse, including phosphorylation, metabolism (carbohydrate and cholesterol biosynthesis), RNA processing, redox-related and signaling regulation (Ras, GTPase, serotonin uptake, nitric oxide response). Several terms are obsolete, and there is no clear single biological theme tying these proteins together, suggesting the cluster lacks a cohesive function. ","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":3},{"id":"GO:0006695","count":3},{"id":"GO:0008033","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0016310","count":3}]},{"hash":"954310292951727902","title":"Spliceosome-driven mRNA processing and regulation","description":"The terms cluster around spliceosome-mediated splicing, stress-related mRNA stability, and mRNA modification, with supporting links to translation initiation, pointing to a cohesive module of RNA processing and post-transcriptional regulation.","confidence":"High","size":23,"edges":182,"triangles":704,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":19},{"id":"GO:0048026","count":18},{"id":"GO:0031047","count":18},{"id":"GO:0006378","count":18},{"id":"GO:0045292","count":18}]},{"hash":"224114352569663226","title":"RNA processing and ribosome biogenesis","description":"The cluster shows strong enrichment for RNA metabolism and translation-related processes: mRNA splicing, mRNA decay and stability, miRNA turnover, transcription-related activity, plus ribosome biogenesis and formation of the translation preinitiation complex. The larval cuticle development term is likely peripheral/noise, suggesting some multifunctional annotations but not defining the core theme. ","confidence":"Medium","size":23,"edges":145,"triangles":534,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0042254","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0031087","count":3},{"id":"GO:0006351","count":2}]},{"hash":"1774578017156168737","title":"Embryonic organogenesis and tissue development","description":"This cluster is enriched for GO terms across multiple tissues\u2014skeletal muscle, heart, placenta, eye morphogenesis, male gonad, and habenula\u2014pointing to a broad developmental/organogenesis role rather than a single pathway. Some terms also touch on protein degradation and transcription regulation, but the dominant signal is embryonic tissue development.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007519","count":5},{"id":"GO:0001890","count":5},{"id":"GO:0007507","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0042787","count":5}]},{"hash":"1189119016167280685","title":"Embryonic Development and Morphogenesis","description":"The proteins are linked to broad developmental processes across multiple tissues (pancreas, neural crest, digestive tract, eye/cornea, ureteric bud) and include transcription/translation initiation terms, indicating regulation of gene expression during embryogenesis. This suggests a cluster of genes involved in embryonic development and tissue morphogenesis rather than a single specific pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0031018","count":2},{"id":"GO:0001755","count":2},{"id":"GO:0048625","count":2}]},{"hash":"969237773481234460","title":"Bacterial energy metabolism and protein turnover","description":"The cluster\u2019s GO terms include aerobic respiration and proton transmembrane transport, highlighting membrane-based energy production, along with PQQ biosynthesis and protein turnover processes (ubiquitin recycling, negative regulation of proteolysis, bradykinin catabolic process), suggesting a focus on metabolism and protein quality control in bacteria, with a possible nod to host-associated functions via symbiont entry into host cells.","confidence":"Medium","size":23,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":3},{"id":"GO:1902600","count":3},{"id":"GO:0018189","count":2},{"id":"GO:1901143","count":2},{"id":"GO:0051291","count":2}]},{"hash":"158242499263472958","title":"Rho and MAPK Signaling Regulators","description":"This cluster is enriched for regulators of multiple signaling pathways, notably positive regulation of the ERK1/2 MAPK cascade, Rho GTPase signaling, and GPCR-related pathways, with additional hints from cell spreading and cytoskeletal regulation, suggesting a theme of modulators of signaling and cytoskeletal dynamics rather than a single canonical path.","confidence":"Medium","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0070374","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007205","count":4}]},{"hash":"2290337982594956150","title":"Ubiquitin-Dependent Signaling and Chromatin Regulation","description":"The top GO terms point to ubiquitin-dependent protein catabolic processes and protein ubiquitination, coupled with regulation of signaling pathways (JNK cascade, TNF-mediated signaling, I-kappaB phosphorylation) and chromatin-related processes (histone catabolic process, histone acetylation/methylation). This suggests a cohesive module where ubiquitinylation controls immune signaling dynamics and chromatin state, with V(D)J recombination hinting at immune system involvement.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0046328","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0033151","count":5},{"id":"GO:0036205","count":5}]},{"hash":"877641243394116850","title":"Ubiquitin-Dependent Proteolysis","description":"The top GO terms are dominated by ubiquitin tagging and proteasomal degradation processes (ubiquitin-dependent protein catabolic process, protein polyubiquitination, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, ubiquitin-dependent ERAD). This strongly suggests the cluster centers on regulated protein turnover. Additional terms reflect immune defense and stress contexts, but do not outweigh the core ubiquitin-mediated catabolism signal.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0000209","count":10},{"id":"GO:0045087","count":8},{"id":"GO:0051607","count":8},{"id":"GO:0042752","count":7}]},{"hash":"941399393697995718","title":"Endocytosis and Cytoskeletal Signaling in Migration","description":"The top GO terms cluster around clathrin-dependent endocytosis, actin cytoskeleton organization, small GTPase signaling, and cell migration, with related GPCR/IGF signaling, suggesting a cohesive role in coordinating endocytic/cytoskeletal dynamics to drive cell movement and signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072583","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0048009","count":2},{"id":"GO:0007264","count":2}]},{"hash":"1624832832320159398","title":"Steroid Hormone Metabolism and Stress Response","description":"The cluster is driven by GO terms for testosterone biosynthesis and androgen metabolism, plus retinoic acid biosynthesis, indicating steroid and retinoid metabolic activity. It also includes xenobiotic metabolism terms (isoquinoline alkaloid, dibenzo-p-dioxin catabolic) and stress/inflammation signals (response to immobilization stress, regulation of inflammatory response, aldosterone-related blood volume), suggesting a broader hormonal/metabolic and stress-response theme with some cell-cycle regulation associations. Overall, the proteins seem tied to hormonal metabolism and stress-related pathways, with ancillary xenobiotic processing.","confidence":"Medium","size":23,"edges":10,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033076","count":19},{"id":"GO:0061370","count":17},{"id":"GO:0008209","count":17},{"id":"GO:0035902","count":16},{"id":"GO:1900087","count":16}]},{"hash":"1007087879083511289","title":"Cell-cycle control and neural development signaling","description":"Based on the top GO terms, the proteins are enriched for cell cycle control (negative regulation of G0 to G1 transition, mitotic spindle assembly, cell division), transcriptional regulation (DNA-templated transcription), signaling/regulation of GTPase activity and tyrosine phosphorylation, and neural development processes (neural tube closure, neuron projection development, cell polarity). This suggests a cluster of factors coordinating cell-cycle progression with developmental signaling and neural differentiation, including cytoskeletal remodeling and polarity establishment.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070317","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0050731","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0071560","count":4}]},{"hash":"628694924612108297","title":"Diverse Metabolite Biosynthesis","description":"The top GO terms point to biosynthetic processes for various metabolites (menaquinone, antibiotics, dopamine, GABA, taurine) and related activities like pigmentation, suggesting a general theme of metabolic synthesis across diverse compounds, with a few outliers. This supports a label centered on biosynthesis as the core function of the cluster, though it is not perfectly cohesive.","confidence":"Medium","size":22,"edges":111,"triangles":343,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0009234","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0006585","count":4},{"id":"GO:0010761","count":4}]},{"hash":"301512871015614175","title":"Translation Initiation and Development","description":"The cluster shows strong signals for translation initiation and preinitiation complex formation, pointing to protein synthesis control. Coupled with development-related terms (neural tube closure, skeletal system development, multicellular organism development, cell proliferation), this suggests roles in embryonic growth and tissue development. Some stress and defense terms (ER stress\u2013related apoptosis, metal ion response, Gram-positive defense) are present but do not outweigh the core themes. ","confidence":"Medium","size":22,"edges":136,"triangles":443,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002188","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0008283","count":6},{"id":"GO:0001843","count":5},{"id":"GO:0070059","count":5}]},{"hash":"1136125159572421562","title":"Ribosome biogenesis and rRNA processing","description":"The cluster is strongly enriched for terms tied to ribosome production and RNA maturation, including ribosome biogenesis, export of the large ribosomal subunit from the nucleus, and processing/maturation steps of rRNA. Additional terms related to transcription, vesicle transport, microtubule severing, and protein oligomerization likely reflect broader cellular growth and assembly processes that accompany ribosome production and cell division.","confidence":"High","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":8},{"id":"GO:0000055","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0000747","count":4},{"id":"GO:0000447","count":4}]},{"hash":"1333807552110041789","title":"Mitochondrial import and stress response","description":"The cluster is dominated by GO terms for importing proteins into mitochondria (matrix and inner membrane), plus autophagy of mitochondrion and mitochondrial fragmentation in apoptosis, and regulators of mitochondrial calcium, all pointing to mitochondrial protein trafficking coupled with stress and quality-control mechanisms. There is a related term for chloroplast import, but the overall pattern centers on mitochondrial function and stress responses. Hence the label emphasizes mitochondrial import and stress/quality-control roles.","confidence":"High","size":22,"edges":29,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0042493","count":2},{"id":"GO:0071333","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0045037","count":2}]},{"hash":"484853316428180866","title":"Mitochondrial translation and respiration","description":"The cluster\u2019s top GO terms center on mitochondrial functions: translation (including mitochondrial translation), import into the mitochondrial matrix, mitochondrial ribosome assembly, and components of the mitochondrial electron transport chain (NADH to ubiquinone, complex II assembly). Additional terms point to heme and quinone biosynthesis, which support mitochondrial respiration. A brain-development term is present but does not redefine the core mitochondrial theme. Overall, the proteins appear aligned with mitochondrial protein synthesis and energy production, justifying the label.","confidence":"High","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0030150","count":3},{"id":"GO:0021762","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006120","count":1}]},{"hash":"832970260551665465","title":"Rho GTPase signaling and cytoskeletal dynamics","description":"The top GO terms point to Rho/small GTPase signaling (regulation, activation, and activity) and to cytoskeletal-related processes such as cell migration and microtubule-based movement, along with endosome organization. This suggests a module coordinating GTPase-driven cytoskeletal remodeling and vesicle trafficking, with possible relevance to neural cell migration contexts like spinal cord development. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0021510","count":4},{"id":"GO:0007205","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0007264","count":3}]},{"hash":"1039530600680015553","title":"Chromatin organization and heterochromatin maintenance","description":"The top GO terms cluster around heterochromatin formation, chromatin localization to chromatin, centromere function, and sister chromatid cohesion, indicating a group of proteins involved in chromatin structure and chromosome maintenance. While germline development terms (spermatogenesis, oogenesis) appear, they likely reflect shared chromatin remodeling roles rather than a separate pathway; overall the cluster centers on chromatin organization and heterochromatin maintenance.","confidence":"High","size":22,"edges":195,"triangles":1002,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0071169","count":18},{"id":"GO:0000183","count":15},{"id":"GO:0090230","count":14},{"id":"GO:0031509","count":14},{"id":"GO:0034184","count":14}]},{"hash":"578310236405547809","title":"Inflammation, immune defense, and coagulation","description":"This cluster centers on innate immune/inflammatory activities (defense against Gram-positive bacteria, leukocyte migration, complement activation, fractalkine production) and hemostasis (blood coagulation, fibrinolysis). Angiogenesis and transcriptional regulation terms suggest tissue remodeling and gene expression changes during immune responses, linking inflammation, defense, and coagulation into a cohesive theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":14},{"id":"GO:0045766","count":13},{"id":"GO:0050830","count":13},{"id":"GO:0014068","count":13},{"id":"GO:0071333","count":13}]},{"hash":"1574241826373177615","title":"Innate Immune Response","description":"The cluster is dominated by GO terms related to innate immunity and defense against pathogens, including defense response to Gram-positive bacterium, innate immune response, acute-phase response, and response to yeast. While there are several development- and growth-associated terms present, they are less frequent and likely secondary. Therefore, Innate Immune Response is a concise, representative label for this group.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0001501","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0038202","count":3}]},{"hash":"1735371360891041230","title":"Starch and related polysaccharide metabolism","description":"The top GO terms are all related to starch and other polysaccharides (starch biosynthesis and catabolism, maltose, sucrose, amylopectin, glycogen, trehalose, alpha-glucans) and polysaccharide digestion. This suggests the cluster shares a cohesive role in polysaccharide metabolism, particularly starch-related pathways.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000023","count":4},{"id":"GO:0010021","count":4},{"id":"GO:0005985","count":4},{"id":"GO:0019252","count":4},{"id":"GO:0005983","count":4}]},{"hash":"151133773302778512","title":"Neural development and cytoskeletal regulation","description":"The top GO terms cluster around neural development (brain, spinal cord, retina) and cytoskeleton-related processes (microtubule-based movement, GTPase signaling), suggesting a coherent theme of neural development coupled with cytoskeletal dynamics. A few terms (defense response, prosthetic gland development, thrombin signaling, angiogenesis) appear unrelated noise, but do not outweigh the central neural-cytoskeletal signal.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0045725","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0007018","count":2}]},{"hash":"1369149445747663596","title":"Chemical Signaling and Olfactory/Pheromone Response","description":"This cluster is dominated by GO terms tied to chemical signaling and perception, including positive regulation of chemokine production, production of inflammatory mediators, pheromone response, sensory perception of smell, and social behavior, pointing to a shared theme of chemical communication and sensory/immune signaling. Additional terms for carbohydrate metabolism, chitin catabolic process and transport suggest metabolic context in organisms with chitin-rich structures, while an isolated term for ergothioneine biosynthesis may reflect annotation noise or a rare pathway. Overall, the core signal is chemical signaling and sensory/immune mediator production.","confidence":"Medium","size":21,"edges":49,"triangles":19,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0006810","count":2}]},{"hash":"1242024196011805981","title":"Embryonic organ morphogenesis","description":"This cluster is dominated by GO terms for multiple organ development processes during embryogenesis (eye, pancreas, lung, digestive tract, neural crest, ureteric branching, primitive streak). The co-occurrence with RNA polymerase II transcription and its negative regulation suggests coordinated gene expression control during these morphogenetic events. Overall, the terms point to a network of factors guiding embryonic organ formation and tissue branching.","confidence":"High","size":21,"edges":106,"triangles":156,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0000122","count":9},{"id":"GO:0031018","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0060441","count":8}]},{"hash":"430602717622847434","title":"RNA processing and translation control","description":"The cluster shows enrichment for RNA biology terms: splicing (via spliceosome and alternative splicing), mRNA modification, translation preinitiation complex formation, regulation of translation initiation, and ncRNA-mediated gene silencing, suggesting a core theme of RNA metabolism and control of gene expression at RNA processing and translational levels. A single outlier term about larval cuticle development is present but does not define the group.","confidence":"Medium","size":21,"edges":197,"triangles":1108,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5},{"id":"GO:0048026","count":2},{"id":"GO:0016556","count":2},{"id":"GO:1902625","count":2},{"id":"GO:1901407","count":2}]},{"hash":"1372380231661664949","title":"Post-transcriptional RNA processing and translation initiation","description":"The dominant GO terms center on mRNA splicing (spliceosome), mRNA export, translation initiation regulation, and mRNA modification, indicating a cluster of proteins involved in post-transcriptional RNA processing and control of translation initiation.","confidence":"High","size":21,"edges":188,"triangles":970,"max_degree":20,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006406","count":3},{"id":"GO:1900363","count":3}]},{"hash":"1502102340354839259","title":"Diverse membrane solute transporters","description":"This cluster is dominated by transmembrane transport GO terms for a variety of solutes (nitrate, organic anions and cations, D-glucose, D-xylose, selenite) indicating a core theme of nutrient uptake across membranes. The presence of a larval cuticle development term is likely incidental to some proteins in this group, not the main shared function. Therefore, the label reflects the primary activity: membrane solute transport.","confidence":"Medium","size":21,"edges":182,"triangles":911,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0015706","count":3},{"id":"GO:0043252","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0070715","count":3}]},{"hash":"527104467262240313","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0048254","count":2},{"id":"GO:0000480","count":2}]},{"hash":"1989193921912736749","title":"Transmembrane Ion and Metabolite Transporters","description":"The top GO terms point to transmembrane transport of multiple ions (sodium, potassium, nitrite/nitrate, phosphate) and small molecules (arabinose, vitamins), plus a related function of neurotransmitter loading into vesicles. This pattern strongly indicates a cluster of membrane transporter proteins with broad substrate specificity, rather than enzymes or structural proteins. The label captures the shared theme of membrane transport across diverse substrates.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0015706","count":5},{"id":"GO:0042128","count":5},{"id":"GO:0015751","count":5}]},{"hash":"704067863556029434","title":"Unknown","description":"The GO terms in this cluster are highly diverse, spanning ribosome biogenesis, cell cycle, development, stress and signaling responses, and even synaptic plasticity, with no single dominant function or connected pathway linking the proteins. The lack of edges supports treating this as a heterogeneous set rather than a cohesive functional group.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051534","count":2},{"id":"GO:0043111","count":2},{"id":"GO:0001701","count":2}]},{"hash":"1045045138348599795","title":"Coagulation and vascular inflammatory signaling","description":"The cluster shows strong representation of blood coagulation terms and responses to inflammatory stimuli (lipopolysaccharide, prostaglandin), along with endothelial barrier regulation and circadian rhythm involvement. This pattern points to a cohesive module centered on coagulation linked to vascular inflammatory signaling and endothelial function, with some peripheral links to circadian regulation.","confidence":"Medium","size":21,"edges":33,"triangles":0,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":9},{"id":"GO:0032496","count":9},{"id":"GO:0018298","count":9},{"id":"GO:0046960","count":8},{"id":"GO:1903141","count":8}]},{"hash":"1824189920176875909","title":"Multisubstrate Membrane Transport","description":"The cluster is dominated by transmembrane transport GO terms covering nitrate, various sugars (glucose, xylose, arabinose), organic anions/cations, and selenite, suggesting a membrane transport module that handles diverse substrates; a peripheral carbohydrate metabolism term (lactose biosynthetic process) may reflect related metabolic context.","confidence":"High","size":21,"edges":147,"triangles":573,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":21},{"id":"GO:0043252","count":21},{"id":"GO:0042128","count":21},{"id":"GO:0070715","count":21},{"id":"GO:0052106","count":21}]},{"hash":"1438380924903107927","title":"Mitotic Regulation and Stress Signaling","description":"GO terms strongly point to cell cycle control, notably mitotic cell cycle and APC-dependent catabolic processes, suggesting roles in mitosis. They also cluster around stress and signaling pathways, including unfolded protein response and ER stress\u2013related translation, dsRNA/interferon responses, and steroid receptor complex assembly, with a plant cytokinin signal term that can cross-talk with division control. The mixture implies proteins that coordinate cell division with cellular stress responses rather than a single specialized pathway. Therefore the label captures both axes: mitotic regulation intertwined with stress signaling.","confidence":"Medium","size":21,"edges":20,"triangles":0,"max_degree":19,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0009736","count":12},{"id":"GO:0051301","count":11},{"id":"GO:0036494","count":10},{"id":"GO:2000531","count":10},{"id":"GO:0031145","count":10}]},{"hash":"410604897171758457","title":"Amino acid import across plasma membrane","description":"Top GO terms show import of multiple amino acids (e.g., L-ornithine, methionine, arginine, lysine) across the plasma membrane, plus polyamine transport regulation and related transmembrane transport. This points to a cohesive theme of amino acid and related substrate uptake across membranes, with peripheral terms like cell volume homeostasis and NO production not altering the core function. Therefore the cluster is best labeled as amino acid import across the plasma membrane.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097640","count":2},{"id":"GO:0044690","count":2},{"id":"GO:1902269","count":2},{"id":"GO:0006527","count":2},{"id":"GO:0097639","count":2}]},{"hash":"608958593434410597","title":"Ribosome Biogenesis and Iron Homeostasis","description":"The two most frequent GO terms are ribosome biogenesis and intracellular iron ion homeostasis (both appearing twice), suggesting a shared theme around basic cellular machinery and metal ion regulation. Other terms relate to apoptosis, ubiquitination, and cell cycle but are less prominent, so the core signal is maintenance of ribosome assembly coupled with iron balance.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0006879","count":2},{"id":"GO:0045849","count":1},{"id":"GO:0043066","count":1},{"id":"GO:2001271","count":1}]},{"hash":"632209236732996032","title":"Inflammatory cytokine and chemokine signaling","description":"Top GO terms indicate a cohesive theme around immune and inflammatory processes: cytokine production, chemokine signaling, neutrophil extravasation, and IL-1\u2013mediated signaling, with supporting growth factor receptor signaling (EGF/IGF) and Rho-mediated pathways that govern cell movement and signaling. Although heart development appears among terms, the prevailing function across the cluster points to immune communication and leukocyte trafficking.","confidence":"High","size":21,"edges":18,"triangles":0,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0048009","count":4},{"id":"GO:0071364","count":4}]},{"hash":"1999236582021024709","title":"Vertebrate Development and Apoptotic Signaling","description":"The top GO terms center on vertebrate development (forebrain and neural tube development, skeletal system development, multicellular organism development) and transcriptional regulation, with concurrent signals for apoptosis (execution phase, ER stress\u2013induced intrinsic pathway) and stress responses (cadmium ion). This pattern suggests a cluster of proteins involved in developmental regulation that also engage in stress-related apoptosis and signaling, rather than a single narrow function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0097194","count":4},{"id":"GO:0001843","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0071276","count":3}]},{"hash":"562698201464643119","title":"Oxidative Stress Response and Phosphorylation Signaling","description":"This cluster centers on cellular responses to oxidative stress (hydrogen peroxide) and protein phosphorylation, indicating redox signaling and post-translational regulation. There are also hints of regulatory roles in neuron projection development and amino acid starvation responses, suggesting broader signaling rather than a single, cohesive pathway. Given these mixed themes, the label reflects the strongest, recurring themes (oxidative stress response and phosphorylation) with moderate confidence due to the heterogeneity.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0016310","count":2},{"id":"GO:1900026","count":2}]},{"hash":"1612340015519336126","title":"Hormone biosynthesis and detoxification","description":"This cluster is enriched for GO terms involving biosynthesis of signaling molecules (retinoic acid, ecdysone) and hormone-regulated processes, together with detoxification/metabolic pathways (epoxygenase P450, dibenzo-dioxin catabolic process). While there are some development and stress-related terms, the common theme center around hormone biosynthesis/signaling and related metabolism.","confidence":"Medium","size":21,"edges":65,"triangles":70,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0019373","count":21},{"id":"GO:0035902","count":20},{"id":"GO:1900087","count":20},{"id":"GO:0019341","count":20},{"id":"GO:2001037","count":20}]},{"hash":"712321972918873142","title":"Cardiac muscle contraction and sarcomere organization","description":"The top GO terms are dominated by cardiac muscle contraction, sarcomere organization, and regulation of heart rate, pointing to a cohesive theme of heart muscle function and sarcomere assembly/regulation. While a few terms (microtubule movement, spinal cord development, spicule insertion, T cell activation) are more peripheral or noisy, the core signal centers on cardiac muscle processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0060048","count":6},{"id":"GO:0003065","count":4},{"id":"GO:1904753","count":4},{"id":"GO:0034609","count":4},{"id":"GO:0045214","count":4}]},{"hash":"495431608434334580","title":"Lipid Metabolism and Lipoprotein Homeostasis","description":"The top GO terms cluster around triglyceride and phospholipid catabolism, cholesterol and phospholipid homeostasis, lipoprotein remodeling and signaling, and regulation of lipoprotein storage and clearance. This points to a cohesive function in lipid metabolism and lipoprotein regulation rather than other cellular processes. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":7},{"id":"GO:0042632","count":6},{"id":"GO:0055091","count":6},{"id":"GO:0010886","count":6},{"id":"GO:0034374","count":6}]},{"hash":"1850212821541684121","title":"Developmental transcription and RNA processing","description":"This cluster shows enrichment for developmental processes such as hair follicle morphogenesis, endocrine system development, pancreatic cell development, liver regeneration, and trophoblast differentiation, alongside nuclear gene expression activities like RNA polymerase II transcription regulation, mRNA splicing, and ribosomal subunit export. The combined themes suggest a role in developmental regulation of gene expression, though the proteins appear functionally diverse. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0043951","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0000398","count":2}]},{"hash":"2031587944660717501","title":"Inflammation and Coagulation Pathways","description":"This cluster is enriched for terms related to leukocyte migration, complement activation, defense against bacteria, and coagulation/fibrinolysis, indicating a focus on innate immune response and coagulation processes. While transcriptional regulation terms are present, the strongest signals point to inflammation and coagulation, with possible links to extracellular remodeling (collagen catabolic process) and cytokine production (fractalkine). High","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0045944","count":12},{"id":"GO:0007596","count":11},{"id":"GO:0051919","count":11},{"id":"GO:0002523","count":11}]},{"hash":"1850434337372150880","title":"Neural development and myelination","description":"The top GO terms cluster around neural development and connectivity: myelination, axonal fasciculation, and positive regulation of synapse assembly, along with inner-ear related processes (otolith morphogenesis) and vestibular reflexes, suggesting a coherent theme of neural maturation and neural circuit formation. Some terms (innate immune response, floral meristem regulation) appear as noise or cross-species artifacts and do not fit the core theme, but the dominant signals point to neural development and myelination.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042552","count":8},{"id":"GO:0014068","count":7},{"id":"GO:0045087","count":6},{"id":"GO:0007413","count":6},{"id":"GO:0032474","count":6}]},{"hash":"847199096399518143","title":"Innate Immune Signaling and Inflammation","description":"The top GO terms point to defense against pathogens and inflammatory processes (defense response to virus, inflammatory response, NOD2 signaling pathway, GPCR-PLC signaling), with protein turnover (ubiquitin-proteasome) accompanying signaling. Mechanical stimulus and collagen fibril organization imply tissue remodeling during inflammation, while transcription-related terms reflect broader gene regulation. Overall, the cluster seems enriched for innate immune signaling and inflammatory responses with some ECM remodeling components.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0051607","count":2},{"id":"GO:0070431","count":2}]},{"hash":"1775400458131978352","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":171,"triangles":844,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":9},{"id":"GO:1903608","count":7},{"id":"GO:0071035","count":7},{"id":"GO:0000480","count":7},{"id":"GO:0000467","count":7}]},{"hash":"487985175489373313","title":"Multicellular Development and Growth Signaling","description":"This cluster is dominated by terms tied to development and growth in multicellular organisms (multicellular organism development, multicellular organism growth, skin development) and by cell-cycle and signaling activities (mitotic cell cycle, positive regulation of GTPase activity, positive regulation of protein autophosphorylation). While immune and hypoxia-related terms appear, they seem secondary to the main theme of development and growth signaling in multicellular contexts.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0050830","count":6},{"id":"GO:0035264","count":6},{"id":"GO:0071456","count":6},{"id":"GO:0051028","count":6}]},{"hash":"2063511575763947867","title":"Developmental transcription and lineage specification","description":"The top GO terms show core transcriptional activity (DNA-templated transcription, RNA polymerase II transcription) coupled with numerous lineage- and tissue-specific differentiation terms (pancreatic development, muscle differentiation, spinal cord neuron/oligodendrocyte fate, bronchiole development). This pattern points to a cluster of proteins involved in developmental gene regulation that drives cell fate decisions across multiple lineages.","confidence":"High","size":20,"edges":100,"triangles":275,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0031018","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0035914","count":7},{"id":"GO:0045668","count":7}]},{"hash":"2147576223938086234","title":"Angiogenesis and renin-angiotensin signaling","description":"The cluster is dominated by terms tied to blood vessel formation and vascular development (positive regulation of angiogenesis, angiogenesis maturation, multicellular organism development, cell differentiation) and to the renin-angiotensin system that regulates systemic blood pressure (angiotensin maturation, regulation of systemic arterial blood pressure by renin-angiotensin). The presence of cell-cell signaling and membrane protein ectodomain proteolysis suggests signaling and receptor processing essential to these pathways. While a term about symbiont entry into host cells appears, the core theme centers on angiogenic and renin-angiotensin\u2013related vascular biology.","confidence":"Medium","size":20,"edges":41,"triangles":24,"max_degree":12,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0045766","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0002005","count":3},{"id":"GO:0007267","count":3},{"id":"GO:0002003","count":3}]},{"hash":"348648086271786299","title":"Muscle contraction regulation and sarcomere organization","description":"Top terms are dominated by muscle-specific processes: slow-twitch and fast-slow fiber transitions, regulation of both striated and overall muscle contraction, muscle filament sliding, and sarcomere organization. This pattern points to a cohesive cluster focused on muscle contraction mechanics and sarcomere structure, with some downstream regulatory effects on tissue-level physiology.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031444","count":2},{"id":"GO:0032780","count":2},{"id":"GO:0014883","count":2},{"id":"GO:0030049","count":2},{"id":"GO:0006940","count":2}]},{"hash":"1571490254239645195","title":"Larval chitin-based cuticle development","description":"The strongest signals are in larval chitin-based cuticle development and related cuticle formation, with body morphogenesis also represented; a few terms point to regulatory processes such as protein deubiquitination and DNA-binding regulation.","confidence":"High","size":20,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0010171","count":2},{"id":"GO:0040003","count":2},{"id":"GO:0043392","count":1},{"id":"GO:0042981","count":1}]},{"hash":"345614016230625977","title":"Unknown","description":"The GO terms span neural development and signaling (e.g., sympathetic nervous system development, axon fasciculation) alongside immune/inflammatory processes and unrelated metabolic or structural processes (bone development, chitin catabolism, carbohydrate metabolism), offering no single coherent functional theme for the cluster. Therefore a concise, representative label cannot be confidently assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019800","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0006032","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0002532","count":2}]},{"hash":"1811342290303133420","title":"Ribosome biogenesis and rRNA processing","description":"The cluster shows strong enrichment for ribosome biogenesis and rRNA maturation terms (maturation of LSU rRNA, maturation of 5.8S rRNA, ITS1 cleavage) and translation, indicating a nucleolar/ribosome-assembly core. While there are some developmental GO terms present, they appear ancillary to the dominant ribosome-related signals. Confidence reflects the clear link to ribosome production and RNA processing.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0001890","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0043433","count":3}]},{"hash":"1348138670107034142","title":"Muscle development and signaling","description":"The Top Terms are dominated by muscle-related processes: muscle organ morphogenesis, muscle cell fate specification, and skeletal muscle acetylcholine-gated channel clustering. There are also signaling-related terms (intracellular signal transduction and negative regulation of protein tyrosine kinase activity) suggesting coordinated regulation of pathways during muscle development. A few terms pertain to hematopoietic lineages (megakaryocyte development, erythrocyte differentiation, regulation of hemocyte differentiation), which appear less represented, but do not override the strong muscle theme. Overall, the cluster seems focused on muscle differentiation and the associated signaling mechanisms.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":3},{"id":"GO:0045347","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0007301","count":2},{"id":"GO:0048644","count":2}]},{"hash":"1032738643809677041","title":"Cholesterol Homeostasis and Lipid Transport","description":"This cluster is dominated by GO terms for cholesterol homeostasis, efflux, and intestinal absorption, pointing to lipid cholesterol handling as the core function. Additional terms span RNA processing and ER-associated pathways, suggesting some annotation noise or mixed functions, but the cholesterol-related terms are the strongest signal.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042632","count":2},{"id":"GO:0033344","count":2},{"id":"GO:0030299","count":2},{"id":"GO:1903715","count":2},{"id":"GO:0034244","count":2}]},{"hash":"544916405620022478","title":"DNA Damage Response and Detoxification","description":"This cluster's top GO terms cluster around DNA damage response, notably nucleotide-excision repair and SOS response, indicating a core DNA repair/stress signaling function. The other terms point to detoxification and transport processes (antibiotic response, heavy metal response, and various transport/export activities) that commonly accompany cellular defense mechanisms, suggesting a broader stress-response role with a DNA repair core.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006289","count":3},{"id":"GO:0015910","count":2},{"id":"GO:1900753","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0099133","count":2}]},{"hash":"2032889981914594965","title":"Neural Development and Signaling","description":"The Top Terms show a clear emphasis on nervous system development and neurogenesis (nervous system development, hippocampus development, neurogenesis) along with key developmental signaling pathways (Smoothened signaling pathway, Roundabout signaling pathway). Additional terms for heart and kidney development, and apoptotic processes, suggest a broader developmental program with a neural focus and associated signaling cascades. This combination supports labeling the cluster as Neural Development and Signaling.","confidence":"Medium","size":20,"edges":127,"triangles":325,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0021766","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0001822","count":6}]},{"hash":"1202605187447844333","title":"Mitochondrial translation and tRNA charging","description":"The top GO terms show translation and several mitochondrial tRNA aminoacylation processes (threonyl-, glycyl-, seryl-, prolyl-), plus regulatory aspects of translational fidelity and related biosynthetic steps. This pattern indicates a cohesive cluster centered on mitochondrial protein synthesis and the charging of mitochondrial tRNAs. ","confidence":"High","size":20,"edges":31,"triangles":6,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0070159","count":1},{"id":"GO:0070150","count":1},{"id":"GO:0070158","count":1}]},{"hash":"348410150542179361","title":"Postsynaptic organization and PSD-95 clustering","description":"The cluster is enriched for GO terms tied to synapse structure and function, notably synapse organization, postsynaptic density protein 95 clustering, and regulation of inhibitory postsynaptic potential, plus receptor internalization. While there are other terms like retina development and osteoblast development appearing, the dominant functional theme is postsynaptic organization and signaling.","confidence":"Medium","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0002087","count":13},{"id":"GO:0002076","count":13},{"id":"GO:0060041","count":13},{"id":"GO:0050808","count":11},{"id":"GO:0097151","count":11}]},{"hash":"107085878785290892","title":"Adaptive immune signaling and ubiquitination","description":"Based on the top terms, the cluster is enriched for adaptive immune processes such as B cell receptor signaling, type 2 immune response, and regulation of IgE isotype switching, pointing to adaptive immune signaling. The presence of ubiquitin-dependent protein catabolic processes and K33-linked ubiquitination suggests coordinated protein turnover and post-translational modification. Some terms like gravitropism and phototropism seem peripheral or incidental; overall, the dominant theme centers on immune signaling coupled with ubiquitin-mediated regulation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0048294","count":4},{"id":"GO:0009958","count":4},{"id":"GO:0042092","count":4}]},{"hash":"1425958390240395461","title":"Inflammation and coagulation responses","description":"The top GO terms cluster around immune and inflammatory processes (leukocyte migration, complement activation, IL-8 regulation, fractalkine production, response to LPS) and coagulation/fibrinolysis, with some remodeling-related terms (collagen catabolic process). These point to a coherent theme of inflammatory and hemostatic signaling, despite one outlier term like midbrain development that may reflect broader annotations.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0030901","count":12},{"id":"GO:0032496","count":9},{"id":"GO:0007596","count":8},{"id":"GO:0051919","count":8}]},{"hash":"384173438222505252","title":"Coagulation and innate immune activation","description":"The top GO terms cluster around blood coagulation and classical complement activation, with additional terms for defense against fungi/yeast, leukocyte recruitment, Toll signaling, and extracellular matrix remodeling. This pattern suggests a cohesive inflammatory program where coagulation and innate immune signaling are coordinated with tissue remodeling processes. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":15},{"id":"GO:0006958","count":15},{"id":"GO:0060309","count":15},{"id":"GO:0050832","count":15},{"id":"GO:1903238","count":15}]},{"hash":"1179427668007852430","title":"Transcription Regulation and Metabolic Salvage","description":"The dominant GO terms point to transcriptional control (DNA-templated transcription and negative regulation of RNAP II\u2013mediated transcription) with phosphorylation as a common regulatory mechanism. Some terms about methionine salvage and threonine biosynthesis appear as peripheral metabolic signals, and a couple heart-related terms may reflect context rather than core function. Overall, the cluster seems centered on transcriptional regulation with some metabolic links.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0019509","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0009088","count":3}]},{"hash":"623857468447032275","title":"Secretory pathway and membrane lipid biosynthesis","description":"The presence of COPII-coated vesicle cargo loading and intracellular protein transport points to vesicle trafficking in the secretory pathway. CDP-diacylglycerol biosynthesis aligns with membrane lipid production required for vesicle membranes. Mitochondrial ATP synthesis indicates energy supply for trafficking processes, and terms related to retina and visual perception may reflect specialized neuronal membrane trafficking. The virus-related term likely reflects how viruses exploit host transport, but the core theme remains vesicle trafficking and membrane biosynthesis.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090110","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0046726","count":2},{"id":"GO:0097284","count":2},{"id":"GO:0021747","count":2}]},{"hash":"1690769697709031068","title":"Dendritic Spine Morphogenesis and Synaptic Plasticity","description":"The top GO terms point strongly to neuronal synapses and dendritic spine development\u2014dendritic spine morphogenesis, synapse organization, receptor clustering, protein localization to synapse, and positive regulation of synapse structural plasticity\u2014along with Rho signaling that drives cytoskeletal changes. Some terms about endothelial barrier and dendritic cell apoptosis are less central, but the dominant theme is synapse formation and plasticity.","confidence":"High","size":19,"edges":68,"triangles":108,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060997","count":8},{"id":"GO:0008285","count":8},{"id":"GO:0090557","count":8},{"id":"GO:0035418","count":8},{"id":"GO:0007266","count":8}]},{"hash":"1660154931948577626","title":"RNA Processing and Splicing Regulation","description":"The proteins cluster around post-transcriptional RNA control: ncRNA-mediated gene silencing, stress-responsive mRNA stability regulation, and multiple spliceosome\u2013mediated splicing steps, plus mRNA modification and translation initiation readiness. This combination indicates a cohesive module governing RNA processing, splicing, and subsequent translation control.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":12},{"id":"GO:0010610","count":12},{"id":"GO:0048026","count":11},{"id":"GO:0006378","count":9},{"id":"GO:0045292","count":9}]},{"hash":"1546218713912841615","title":"Mitochondrial nucleotide and metabolite transport","description":"These terms converge on mitochondrial import of nucleotides and other metabolic substrates (nucleotides, glycine, alpha-ketoglutarate, ornithine), as well as processes tied to mitochondrial energy status (membrane potential, thermogenesis). So the cluster likely represents mitochondrial metabolite transport and energy regulation.","confidence":"High","size":19,"edges":105,"triangles":244,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0097274","count":14},{"id":"GO:0051881","count":14},{"id":"GO:0030302","count":14},{"id":"GO:0070542","count":14},{"id":"GO:1990845","count":14}]},{"hash":"1845490203073682937","title":"Proteolysis-driven remodeling and immune signaling","description":"These proteins are enriched for fibrinolysis, plasminogen activation, and regulation of angiogenesis, indicating roles in extracellular matrix remodeling. The presence of complement activation terms further supports immune modulation. While some terms touch on stress response or secretion, the dominant theme ties proteolytic remodeling to immune signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":6},{"id":"GO:0045766","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0010519","count":4}]},{"hash":"1649699093737296010","title":"Calcium signaling and transcription regulation","description":"These proteins appear to be tied together by Ca2+-dependent signaling pathways: regulation of ryanodine-sensitive and store-operated calcium channels, regulation of calcineurin-NFAT signaling, and associated processes like protein dephosphorylation and regulation of DNA binding, which together influence transcription and synaptic plasticity (long-term potentiation). The hydrogen peroxide biosynthetic term points to redox signaling often interconnected with calcium signaling, while the metanephric development term may reflect broader developmental roles of Ca2+ signaling. Overall, the cluster centers on Ca2+-mediated signaling and transcriptional control, with a few peripheral developmental cues. ","confidence":"Medium","size":19,"edges":94,"triangles":211,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060316","count":7},{"id":"GO:1903799","count":7},{"id":"GO:0050665","count":7},{"id":"GO:0035502","count":7},{"id":"GO:0032972","count":7}]},{"hash":"336289792328513901","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0030575","count":1},{"id":"GO:0010587","count":1},{"id":"GO:0010323","count":1}]},{"hash":"2016683712722022886","title":"Unknown","description":"The top terms span several unrelated processes (splicing, neuronal growth-factor response, hypoxia, meiotic gene conversion, cell cycle regulation/division, and multiple amino acid transports). With no dominant shared function or pathway across the proteins, there is no cohesive theme to anchor a meaningful label.","confidence":"","size":19,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:1990416","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0006311","count":2},{"id":"GO:0007050","count":2}]},{"hash":"1704710531610837869","title":"Actin cytoskeleton remodeling and lamellipodium assembly","description":"This cluster is dominated by GO terms tied to actin dynamics: lamellipodium assembly, barbed-end and pointed-end capping, actin filament polymerization and severing, actin bundle assembly, and overall actin cytoskeleton organization. Together these indicate a core theme of rapid actin remodeling at the cell edge and protrusion formation (lamellipodia/ruffles). Some developmental terms (uterus development, larval cuticle development) may reflect actin-driven tissue remodeling, but the primary signal centers on actin filament dynamics. ","confidence":"High","size":19,"edges":92,"triangles":212,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":4},{"id":"GO:0051016","count":4},{"id":"GO:0030041","count":4},{"id":"GO:0051014","count":4},{"id":"GO:0051017","count":3}]},{"hash":"35949855945238417","title":"Developmental Cytoskeletal Signaling in Cartilage and Skin","description":"The cluster centers on developmental processes such as cartilage condensation and skin development, and is enriched for cytoskeletal organization terms (actin and cortical actin, centrosome localization, and protein localization to microtubules) along with collagen-driven signaling pathways. This points to a coherent theme where extracellular cues (collagen signaling) guide cytoskeletal remodeling to drive tissue formation in skin and cartilage, though a few broader terms (visual perception, synaptic depression) appear as outliers. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001502","count":4},{"id":"GO:0038063","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0060292","count":3},{"id":"GO:2000251","count":3}]},{"hash":"875045143427820833","title":"Mitochondrial Metabolite Transport","description":"The GO terms point to transport of diverse metabolites into or within mitochondria (deoxynucleotides, pyrimidines, alpha-ketoglutarate, glycine, ornithine) and to mitochondrial membrane potential regulation and energy-related processes such as adaptive thermogenesis and liver metabolism. The presence of ornithine/urea cycle-related transport alongside these metabolism terms supports a cohesive theme of mitochondria-centered metabolite transport and energy homeostasis.","confidence":"High","size":19,"edges":39,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0097274","count":10},{"id":"GO:0051881","count":10},{"id":"GO:0030302","count":10},{"id":"GO:0070542","count":10},{"id":"GO:1990845","count":10}]},{"hash":"459490806462841272","title":"Transcription, RNA processing, and DNA replication","description":"The cluster shows multiple GO terms tied to core gene expression: DNA-templated transcription, mRNA capping, RNA splicing, and DNA replication, with a secondary signal of microtubule regulation. Immune-related and development terms appear sparsely, suggesting background noise rather than a cohesive function. Overall, it points to components involved in transcription and RNA processing alongside DNA replication.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031116","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0008380","count":2}]},{"hash":"1403167815556149631","title":"Neural Development and Sensory Function","description":"The top GO terms are dominated by neural development and sensory-related processes (telencephalon development, neural tube closure, sensory perception of pain) with supporting signals of general organism development. A few terms relate to immune signaling and host interactions, but the strongest cohesive theme appears to be nervous system development and sensory function, with some metabolic context (glucose stimulus) as secondary. ","confidence":"Medium","size":19,"edges":47,"triangles":37,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071333","count":13},{"id":"GO:0043330","count":13},{"id":"GO:0007275","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0020021","count":11}]},{"hash":"986019970812175558","title":"Drug/toxin stress response","description":"This cluster centers on responses to chemicals and DNA damage (antibiotics, mercury, doxorubicin, SOS response), suggesting a general cellular defense mechanism to toxic insults. While some terms touch on transcription or transport, the dominant theme is stress response to toxicants and DNA damage rather than a single metabolic pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0007584","count":3},{"id":"GO:0006351","count":3},{"id":"GO:2001246","count":2},{"id":"GO:0015910","count":2}]},{"hash":"1251482979538215321","title":"Nutrient-Responsive Growth and Development","description":"The GO terms indicate both core gene expression (DNA-templated transcription, rRNA processing) and cell-cycle processes (mitotic cell cycle, cell division), coupled with nutrient-sensing via TORC1 signaling and a clear developmental signal (antennal and compound eye photoreceptor development). This suggests proteins in this cluster participate in coordinating growth and development in response to nutrients, rather than a single dedicated pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007064","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1091893900362583513","title":"Innate immune signaling and inflammation","description":"The GO terms show a clear emphasis on innate immune and inflammatory processes, including LPS signaling, peptidoglycan recognition protein signaling, inflammatory response, and regulation of TNF production and extrinsic apoptosis. Some terms appear more peripheral (e.g., cholesterol transport, eye morphogenesis), but the dominant theme is immune sensing and inflammatory signaling, so the label reflects the cluster\u2019s likely shared function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001246","count":2},{"id":"GO:0070236","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0032760","count":2},{"id":"GO:0032367","count":2}]},{"hash":"119062511062537352","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0007224","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0097350","count":2},{"id":"GO:0001764","count":2}]},{"hash":"2288266445244541163","title":"Embryonic organ morphogenesis","description":"The dominant GO terms describe morphogenesis and patterning during embryonic development across multiple organs (eye, lung, muscle, habenula, gonad) and in utero development. This indicates the cluster's proteins are tied to embryonic tissue formation and developmental patterning rather than a single tissue or process.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0060972","count":8},{"id":"GO:0060441","count":7},{"id":"GO:0043010","count":7}]},{"hash":"128270549367589190","title":"Sterol and lipid biosynthesis with mitochondrial dynamics","description":"Enriched terms point to sterol and fatty acid/lipid metabolism (ergosterol regulation, unsaturated fatty acid biosynthesis, sphingolipid metabolism) together with mitochondrial dynamics (fission, inheritance), suggesting a theme of lipid synthesis linked to organelle maintenance; several terms (nerve/gland differentiation) may reflect annotation noise.","confidence":"Medium","size":19,"edges":25,"triangles":8,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0032443","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0006636","count":2},{"id":"GO:0042128","count":2}]},{"hash":"310938292319692089","title":"Unknown","description":"The cluster's GO terms cover a wide range including developmental processes (somitogenesis, CNS and eye morphogenesis), immune response, and several membrane transport steps (glucose, nitrate, arabinose). There is no clear, single biological function tying these proteins together, and the zero-edge graph suggests annotations are disparate, so a coherent label cannot be assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007341","count":2},{"id":"GO:0005989","count":2},{"id":"GO:0048596","count":2},{"id":"GO:0001756","count":2},{"id":"GO:1904659","count":2}]},{"hash":"816731393578255542","title":"Unknown","description":"The GO terms span very different biological areas (midbrain and pancreas development, multicellular growth; transcription regulation) along with immune/hemostatic signals (leukocyte migration, blood coagulation, fibrinolysis, fractalkine production) and a miscellaneous oxidoreductive term. The cluster lacks a clear, cohesive functional theme or a common pathway, and there are no interactions reported (Edges 0). Therefore no single, representative label can be confidently assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":6},{"id":"GO:0061113","count":6},{"id":"GO:0035264","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0055114","count":5}]},{"hash":"494443553639830581","title":"Inflammation and Immune Signaling with Angiogenesis","description":"The cluster is dominated by GO terms for inflammatory response, innate immune response, and positive regulation of angiogenesis, with supporting terms for NF-kappaB signaling and fibroblast proliferation, suggesting a cohesive theme of immune/inflammatory signaling coupled to tissue remodeling. Some outliers (olfactory learning, retinal axon guidance) are present but do not outweigh the core immune/angiogenesis pattern. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0042346","count":2},{"id":"GO:0048146","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0008355","count":2}]},{"hash":"1319982609744994381","title":"Inflammation, coagulation, and angiogenesis","description":"The top GO terms point to acute-phase inflammatory response, leukocyte migration, coagulation/fibrinolysis, and positive regulation of angiogenesis, suggesting a functional module centered on inflammatory signaling and vascular remodeling; while a couple terms are broad developmental processes, the core theme remains inflammation-related with vascular and coagulation aspects.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":11},{"id":"GO:0000122","count":11},{"id":"GO:0007596","count":9},{"id":"GO:0045766","count":9},{"id":"GO:0014068","count":9}]},{"hash":"1350924341703017419","title":"Membrane Lipid Metabolism and Trafficking","description":"Named for the prominence of lipid biosynthesis regulation and lipid metabolism terms (phosphatidylcholine and phosphatidylglycerol, vitamin E metabolism) together with Golgi-to-plasma membrane transport, suggesting a cluster centered on membrane lipid synthesis and trafficking. Some terms hint at broader metabolic or environmental responses, but the lipid/trafficking theme is the strongest common thread.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":3},{"id":"GO:0009268","count":2},{"id":"GO:1901352","count":2},{"id":"GO:0001892","count":2},{"id":"GO:0043001","count":2}]},{"hash":"1119351355953414416","title":"Neural signaling and glial support","description":"The cluster includes several neural-focused terms: glutamatergic synaptic transmission and behavioral fear response point to neural communication and behavior, while perineurial glial growth suggests glial involvement in neural development or maintenance. The endosome organization and Rab/Rho signaling terms hint at intracellular trafficking and cytoskeletal dynamics essential for synapse function and glial processes. Some terms (bacterial antigen biosynthesis, antibiotic response) may be incidental, but the dominant theme ties to neural signaling and glial biology.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":2},{"id":"GO:0007032","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0001662","count":2}]},{"hash":"699064066633935227","title":"Immune signaling and inflammatory regulation","description":"The top GO terms point to both adaptive and innate immune signaling, including T cell receptor signaling, TNF-mediated signaling, and stimulatory C-type lectin receptor signaling. Additional terms related to regulation of inflammation, deubiquitination, and mRNA stability suggest modulation of immune responses rather than a single metabolic pathway. While there are a few generic terms, the dominant theme is immune communication and inflammatory control, justifying this labeling.","confidence":"High","size":18,"edges":149,"triangles":754,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":7},{"id":"GO:0050852","count":5},{"id":"GO:0031145","count":5},{"id":"GO:0033209","count":5},{"id":"GO:0061418","count":5}]},{"hash":"1822051992366937636","title":"Embryonic Development and Differentiation","description":"The top GO terms point to processes in early development and tissue formation, including trophoblast differentiation, placental development, gastrulation, left-right patterning, and EMT in heart cushion formation, plus cartilage morphogenesis and endocrine system development. A neighboring spliceosome-related term may reflect general gene expression needed during development. Together, they suggest a coherent theme of embryogenesis and cell fate specification.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060972","count":5}]},{"hash":"1293606613676463188","title":"Ribosome Biogenesis and Translational Regulation","description":"This cluster is dominated by GO terms tied to ribosome production and protein synthesis, including translation (GO:0006412), translational initiation/termination (GO:0006413, GO:0006415), and positive regulation of elongation, as well as ribosome biogenesis and large subunit assembly. The convergence of these terms suggests proteins involved in assembling ribosomes and regulating cytoplasmic translation, with a possible link to mRNA decay processes (deadenylation-dependent decay) that often accompany translational control. A single term about glial cell proliferation appears incidental to the core translational theme rather than defining the cluster.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0046677","count":5},{"id":"GO:0006415","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0000027","count":4}]},{"hash":"310646868130696312","title":"Strigolactone biosynthesis and plant metabolite turnover","description":"This cluster is dominated by GO terms tied to strigolactone production and cellular responses to strigolactones, along with various catabolic processes for plant secondary metabolites (stilbenes, chlorophyll, glucuronosides, alkaloids) and lipids. The convergence on strigolactone\u2013related terms plus broad metabolite turnover suggests proteins involved in strigolactone biology and wider plant metabolite catabolism.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0019391","count":3},{"id":"GO:0046272","count":3},{"id":"GO:0015996","count":3}]},{"hash":"158601412937948015","title":"RNA Splicing and Translation Initiation","description":"This cluster is dominated by GO terms for mRNA splicing and spliceosome regulation (splicing site recognition, alternative splicing, spliceosome-mediated processing), plus terms for mRNA export and formation of the translation preinitiation complex, with a related viral translation reinitiation term. Together they point to proteins involved in RNA processing and the assembly/activation of translation initiation machinery. ","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":2},{"id":"GO:0048026","count":1},{"id":"GO:0016556","count":1},{"id":"GO:0051096","count":1},{"id":"GO:1902625","count":1}]},{"hash":"853856384378499391","title":"Wnt/Hippo signaling in keratinocyte differentiation","description":"Top GO terms converge on activation of canonical Wnt signaling, Hippo signaling, and keratinocyte differentiation, along with apoptosis and cell cycle regulation. This suggests a cohesive module coordinating growth, differentiation, and survival in epidermal contexts, regulated by Wnt/Hippo and modulated by TGF-\u03b2 signaling. The cluster likely represents regulators tying these pathways to skin cell fate and proliferation.","confidence":"High","size":18,"edges":10,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":12},{"id":"GO:0060044","count":11},{"id":"GO:0006915","count":11},{"id":"GO:0035329","count":11},{"id":"GO:0030216","count":11}]},{"hash":"2193629741574098254","title":"Skin and bone development with secreted signaling","description":"This cluster centers on skin development and bone ossification, pointing to dermal/osteogenic development, with additional signals related to secreted factors and intercellular communication (chemokine production, vasopressin, gastric secretion). The inclusion of protein homooligomerization suggests shared regulatory interactions among developmental proteins. ","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":9},{"id":"GO:0043588","count":8},{"id":"GO:0051260","count":8},{"id":"GO:0071651","count":7},{"id":"GO:2000340","count":7}]},{"hash":"650743746244527814","title":"Embryonic morphogenesis and organ development","description":"The cluster shows a cohesive theme around developmental processes and tissue formation, with terms like somitogenesis, roof of mouth development, outflow tract morphogenesis, embryonic eye morphogenesis, collagen fibril organization, and multicellular organism development. While a few terms touch calcium signaling and adaptive immunity, the dominant pattern points to embryonic morphogenesis and organogenesis.","confidence":"High","size":18,"edges":12,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0051592","count":2},{"id":"GO:0033689","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0030199","count":2}]},{"hash":"1814768887588011347","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":60,"triangles":105,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0006469","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0036494","count":2},{"id":"GO:0034975","count":2}]},{"hash":"1972977525957095344","title":"Larval Cuticle Development and Solute Transport","description":"This cluster is dominated by the larval chitin-based cuticle development term, suggesting involvement in insect larval cuticle formation. It also contains multiple transmembrane transport terms for nitrate, sugars, organic ions, and related substrates, implying a group of membrane transport proteins operating in a larval developmental context, potentially linked to nutrient uptake and cuticle physiology.","confidence":"Medium","size":18,"edges":116,"triangles":430,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":15},{"id":"GO:0015706","count":2},{"id":"GO:0043252","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0070715","count":2}]},{"hash":"401388346501033278","title":"Golgi- and SNARE-mediated vesicle trafficking","description":"The top GO terms cluster around ER-to-Golgi and intra-Golgi transport, SNARE complex assembly, vesicle fusion with the Golgi, Golgi ribbon formation, and exocytic insertion of neurotransmitter receptors, plus endosome-to-Golgi transport and membrane protein localization. This points to a unified role in Golgi/secretory pathway vesicle trafficking and synaptic membrane delivery.","confidence":"High","size":18,"edges":62,"triangles":85,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":10},{"id":"GO:0048280","count":10},{"id":"GO:0090161","count":9},{"id":"GO:0060291","count":9},{"id":"GO:0006891","count":9}]},{"hash":"1643111950629358419","title":"Mitochondrial dynamics and signaling","description":"This cluster is anchored by terms about mitochondria, including intracellular distribution, inheritance, and genome maintenance, pointing to a core theme of mitochondrial organization and transmission. The presence of signaling terms (ephrin receptor signaling, GABAergic transmission) suggests broader cellular communication roles that can link to mitochondrial function in energy-demanding processes, while other terms (cell division, ribosomal export, endocytic recycling) reflect general cellular housekeeping that often interfaces with organelle dynamics. Overall, the strongest coherent signal is mitochondria-related organization and inheritance, with supporting signaling and trafficking contexts.","confidence":"Medium","size":18,"edges":16,"triangles":2,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":2},{"id":"GO:0048312","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0051260","count":2}]},{"hash":"1609164140905970883","title":"Innate immune signaling and neural development","description":"The top GO terms indicate strong innate immune activity (innate immune response, response to lipopolysaccharide, defense against virus) alongside cytoskeletal and neural-development processes (actin filament severing, myelination, corpus callosum development, axonal fasciculation, collagen organization, otolith morphogenesis). This mix suggests proteins involved in immune signaling with roles in neural development and related cytoskeletal/extracellular matrix remodeling.","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0051014","count":3},{"id":"GO:0045842","count":3},{"id":"GO:0051607","count":3}]},{"hash":"47239844501442646","title":"Actin-driven protrusions and cell migration","description":"This cluster is enriched for GO terms describing actin-based protrusions (filopodium and lamellipodium assembly), enhanced spreading on substrates, and cell migration, all pointing to remodeling of the actin cytoskeleton as a core function. It also includes signaling nodes such as Rac/Ras pathway regulation and insulin signaling, suggesting coordinated signaling to control motility. While some terms relate to immune signaling and myelin maintenance, the strongest, most consistent signal is actin-driven migration.","confidence":"High","size":18,"edges":37,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0030032","count":4},{"id":"GO:0098761","count":3},{"id":"GO:0008286","count":3}]},{"hash":"1744514270010398620","title":"Unknown","description":"The GO terms are highly diverse, spanning gonad development, stress response, cell-cycle regulation, xenobiotic/dioxin metabolism, hormone biosynthesis, and various tissue-specific developmental processes. There isn\u2019t a single clear functional theme that ties all proteins together, making a precise, concise label unreliable. While some terms hint at endocrine or developmental roles, the cluster lacks a cohesive, well-defined function. Therefore, the cluster is best described as Unknown with no confidence in a representative label.","confidence":"","size":18,"edges":20,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":11},{"id":"GO:0035902","count":10},{"id":"GO:1900087","count":10},{"id":"GO:0019341","count":10},{"id":"GO:2001037","count":10}]},{"hash":"77658891956196073","title":"Unknown","description":"The GO terms span plant development (floral meristem growth) and diverse animal processes (immune signaling via TLR4 and IL-13, neural functions like vestibuloocular reflex and myelination, and angiogenesis via VEGF), plus general signaling (GPCR) and mitochondrial regulation. The lack of a single, cohesive biological theme suggests there is no clear shared function linking these proteins.","confidence":"","size":18,"edges":20,"triangles":3,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010080","count":3},{"id":"GO:0071650","count":3},{"id":"GO:0060007","count":3},{"id":"GO:0051901","count":3},{"id":"GO:0034145","count":3}]},{"hash":"202491536275416943","title":"Unknown","description":"The GO terms span developmental processes across tissues (heart, vulval, eye morphogenesis), signaling pathways (GPCR/PKC, thrombin-activated signaling), metabolic transport (sterol transport), and immune regulation (mucosal immunity, IL-8, TLR5 signaling, apoptosis). This broad, non-overlapping mix does not point to a single cohesive function for the cluster. None","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0032366","count":1},{"id":"GO:0072327","count":1}]},{"hash":"1194352832631645920","title":"Unknown","description":"The top GO terms span transcriptional regulation, chromatin-related processes, extracellular and ephrin signaling, neural development and synaptic potentiation, cytoskeleton dynamics, pheromone metabolism, and fatty acid biosynthesis. There is no single cohesive theme linking these functions across the cluster, so a specific, representative label cannot be assigned beyond Unknown.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0035426","count":2},{"id":"GO:0048013","count":2},{"id":"GO:0060291","count":2}]},{"hash":"1269234181003494602","title":"Transcription and Signaling Regulators","description":"The top GO terms point to a mix of regulatory roles across transcription, signaling pathways (including Wnt and Rho), cell cycle control (G1/S transition, spindle assembly), and even processes like pinocytosis or chloroplast import. There isn\u2019t a single cohesive pathway dominating the cluster, but rather a set of proteins that broadly regulate various cellular processes. Confidence: Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070212","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0045038","count":3},{"id":"GO:0051225","count":3}]},{"hash":"774706103418170725","title":"Unknown","description":"The terms span diverse developmental and regulatory processes across multiple organs (ear, brain, lens, vasculature) with no single shared function, so a coherent, specific label isn\u2019t evident.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0007288","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1377539066313940784","title":"Immune signaling and coagulation in inflammation","description":"The top GO terms cluster around immune defense and inflammatory processes (defense response to Gram-positive bacteria, leukocyte migration, complement activation, regulation of IL-8), along with coagulation and fibrinolysis (blood coagulation, positive regulation of fibrinolysis, fractalkine production). A few terms touch on development/remodeling (multicellular organism growth, Wnt signaling, collagen catabolic process), but the dominant theme is immune activation coupled with coagulation and inflammatory signaling, suggesting a coordinated inflammatory response with thrombotic components.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0007596","count":2},{"id":"GO:0051919","count":2},{"id":"GO:0002523","count":2}]},{"hash":"1226140366994859471","title":"Neuronal transmembrane transporters and vesicle loading","description":"The GO terms show a broad set of transmembrane transport activities (nitrate, sialic acid, galactose, arabinose, sodium ions, etc.) plus a neural-specific process (neurotransmitter loading into synaptic vesicles) and a myelination term, suggesting a cluster of membrane transporter proteins with a neural context. The common theme is proteins that span membranes and mediate solute transport, including vesicular neurotransmitter handling in neurons.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0015706","count":1},{"id":"GO:0042891","count":1},{"id":"GO:0015739","count":1},{"id":"GO:0015757","count":1}]},{"hash":"375450455376057613","title":"RNA Decay and Extrinsic Apoptosis Regulation","description":"The predominant GO terms point to RNA metabolism and decay pathways (exonucleolytic activity, deadenylation-independent decay, mRNA catabolic processes), with additional terms indicating regulation of extrinsic apoptotic signaling in the absence of ligand (both positive and negative). The presence of protein heterooligomerization suggests interacting partners within these processes. Together, the cluster seems to encompass both RNA turnover and modulation of extrinsic apoptosis signaling, rather than a single, uniform function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090503","count":2},{"id":"GO:0000012","count":2},{"id":"GO:2001241","count":2},{"id":"GO:2001240","count":2},{"id":"GO:0051291","count":2}]},{"hash":"1697827652106491615","title":"NFAT signaling in larval hematopoiesis","description":"Top GO terms show positive regulation of the calcineurin-NFAT signaling cascade and larval lymph gland hemopoiesis, suggesting a link between NFAT pathway activity and hematopoietic development in the larval lymph gland. The cluster likely contains proteins involved in signaling that guides blood cell formation.","confidence":"Medium","size":17,"edges":91,"triangles":265,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0051533","count":5},{"id":"GO:0035167","count":1}]},{"hash":"1676858447098276131","title":"Redox Regulation, Inflammation, and Regeneration","description":"A cluster dominated by redox-related processes: cellular redox homeostasis, oxidant detoxification, protein glutathionylation, and mitochondrial membrane potential regulation, with additional involvement in prostaglandin signaling and TNF production control, suggesting coordinated oxidative stress response, inflammatory signaling, and growth/regeneration pathways.","confidence":"High","size":17,"edges":92,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":11},{"id":"GO:0098869","count":11},{"id":"GO:2000255","count":10},{"id":"GO:0001516","count":10},{"id":"GO:0051881","count":9}]},{"hash":"1747756934679149324","title":"LPS-induced innate immunity and coagulation","description":"Proteins in this cluster are enriched for responses related to lipopolysaccharide (LPS) sensing and innate immune activation, including response to LPS, leukocyte migration, fractalkine production, and complement activation. Coagulation and fibrinolysis terms, along with collagen catabolic processes, suggest inflammation-associated coagulation and extracellular matrix remodeling. The presence of transcription regulation terms may reflect gene-expression control in immune responses, but the dominant signal points to an innate immune/inflammatory program intertwined with coagulation and tissue remodeling.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0032496","count":10},{"id":"GO:0045944","count":10},{"id":"GO:0007596","count":9},{"id":"GO:0051919","count":9}]},{"hash":"632136492386077357","title":"Neural signaling and axon development","description":"This cluster centers on neural processes: visual perception, axonogenesis, and axon extension, combined with regulation of calcium-dependent exocytosis and phosphorylation\u2014points to signaling networks governing neural development and neurotransmitter release. GO terms like Wnt signaling and PI3K activity further support a theme of broad signal transduction in development. The T cell receptor signaling term is an outlier, likely reflecting shared signaling machinery rather than immune-specific function. Overall, the set appears to reflect neural signaling and axon growth-related proteins.","confidence":"Medium","size":17,"edges":41,"triangles":21,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":16},{"id":"GO:0043552","count":16},{"id":"GO:0007601","count":16},{"id":"GO:0090263","count":16},{"id":"GO:0000086","count":16}]},{"hash":"607164430999177638","title":"DNA replication and mitosis during development","description":"The cluster is dominated by GO terms for DNA replication, mitotic cell cycle, and DNA repair, indicating core roles in cellular proliferation and genome maintenance. The inclusion of developmental processes (neural tube closure, telencephalon development, cranial skeleton morphogenesis, trachea formation) suggests these cell-cycle and repair activities are tied to embryogenesis. Immune signaling and ER-stress\u2013related apoptosis appear secondary contextual associations rather than core themes. Overall, the most representative function is cell-cycle\u2013driven development.","confidence":"Medium","size":17,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":14},{"id":"GO:0000278","count":13},{"id":"GO:0006281","count":13},{"id":"GO:0048701","count":12},{"id":"GO:0060440","count":12}]},{"hash":"633990973687470488","title":"ER protein folding and redox homeostasis","description":"Dominated by GO terms for ER protein folding and redox balance (plus chaperone-dependent refolding), this cluster points to proteins involved in ER proteostasis and oxidative stress response; a few unrelated terms may reflect broader cellular processes or annotation noise.","confidence":"High","size":17,"edges":27,"triangles":8,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":12},{"id":"GO:0045454","count":12},{"id":"GO:0070389","count":8},{"id":"GO:1903206","count":8},{"id":"GO:0016032","count":8}]},{"hash":"179531843511461825","title":"Spliceosome-driven mRNA splicing and regulation","description":"Explanation: Most terms are about spliceosome-mediated mRNA splicing (cis and alternative), plus mRNA processing steps (stability, modification) and RNA-based gene silencing, with a note of translation initiation components, indicating a coherent RNA-processing/regulatory module.","confidence":"High","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":13},{"id":"GO:0031047","count":13},{"id":"GO:0010610","count":11},{"id":"GO:0045292","count":10},{"id":"GO:0016556","count":9}]},{"hash":"1536183534287803863","title":"N-terminal protein acetylation machinery","description":"The enrichment is driven by multiple N-terminal peptidyl-X acetylation terms (serine, methionine, glutamic acid) and general N-terminal acetylation, plus a histone acetylation note, pointing to a shared role in N-terminal acetylation processes and related PTMs. A few other terms appear (angiogenesis, melatonin biosynthesis) that are less cohesive with this theme, but do not override the main signal.","confidence":"Medium","size":17,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":7},{"id":"GO:0061606","count":5},{"id":"GO:0043967","count":5},{"id":"GO:0006041","count":5},{"id":"GO:0017198","count":5}]},{"hash":"1009151942315859963","title":"Regulation of Development and Neurogenesis","description":"This cluster is enriched for GO terms related to regulation of development and differentiation across multiple tissues (bone, muscle, heart, ear, pancreas) as well as neural development processes (neurogenesis, myelination, auditory receptor differentiation). The predominant pattern is negative regulation of differentiation and development, with some neural development signals, suggesting these proteins broadly modulate developmental programs rather than a single tissue-specific pathway.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":14},{"id":"GO:0060766","count":14},{"id":"GO:2000818","count":12},{"id":"GO:0003062","count":12},{"id":"GO:2000764","count":12}]},{"hash":"1274408089776579128","title":"Neuronal mitochondrial energy and microtubule dynamics","description":"These proteins cluster around mitochondrial energy metabolism (electron transport, ATP synthesis, complex II assembly) and mitochondrial translation, alongside microtubule organization and neuron projection development (axonogenesis, neurite outgrowth). This suggests a theme where mitochondrial energy production supports cytoskeletal dynamics and neuronal growth processes.","confidence":"Medium","size":17,"edges":107,"triangles":339,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0034553","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0042775","count":1},{"id":"GO:0007019","count":1}]},{"hash":"2216174996001744781","title":"Endocytosis and membrane remodeling","description":"The cluster shows multiple terms tied to membrane invagination, caveolin-mediated endocytosis, and endocytosis regulation, along with filopodium (cytoskeleton) assembly and membrane protein processing; these point to a common theme of membrane trafficking and cytoskeletal remodeling that control uptake and receptor localization, with osmotic stress signaling as a related membrane-physiology response. The neural and T cell signaling terms may reflect shared signaling contexts but do not override the central endocytic/membrane-centric theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":3},{"id":"GO:0050852","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0001878","count":2},{"id":"GO:0010324","count":2}]},{"hash":"2241896690254212329","title":"Developmental regulation of gene expression","description":"This cluster centers on developmental processes (body morphogenesis and chitin-based cuticle development) and a broad set of regulatory functions at multiple levels of gene expression, including regulation of transcription by RNA polymerase II, ubiquitination, mRNA stability, and cap-independent translation initiation. The mix suggests a cohesive theme of coordinating developmental morphology through transcriptional and post-transcriptional control, though a few terms (e.g., plant defense-related) indicate some functional diversity. Confidence: Medium","confidence":"","size":17,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":3},{"id":"GO:0040003","count":3},{"id":"GO:0071157","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0016567","count":2}]},{"hash":"710175189091231010","title":"Neural development and organogenesis","description":"The top GO terms are dominated by developmental processes across neural tissues (midbrain, brain, dorsal spinal cord, habenula) and related behaviors, with additional but less frequent signals of endocrine pancreas and gonad development. This points to a broad developmental program with a neural emphasis, rather than a single specific pathway, hence a label focused on neural development and organogenesis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007338","count":7},{"id":"GO:0008584","count":7},{"id":"GO:0030901","count":6},{"id":"GO:0031018","count":6},{"id":"GO:0021516","count":6}]},{"hash":"1031728085513035930","title":"Neural and cardiac development with cytoskeletal signaling","description":"The proteins are enriched for neural tube closure and forebrain development, together with cardiac muscle differentiation, and show links to Rho signaling and actin cytoskeleton remodeling. This points to developmental morphogenesis of neural and cardiac tissues driven by cytoskeletal dynamics and associated transcriptional/cell-cycle regulation during development.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001843","count":7},{"id":"GO:0030900","count":7},{"id":"GO:0045736","count":6},{"id":"GO:2000727","count":6},{"id":"GO:0007266","count":6}]},{"hash":"1542372670957504257","title":"Unknown","description":"The top GO terms are diverse, including osmotic stress response, lactose biosynthesis, immune signaling (NK T cell differentiation, B cell receptor signaling, IL-7 response), cytoskeletal and cell\u2013cell interactions (filopodium assembly, endothelial barrier establishment, cell spreading), lipid catabolism, and insulin signaling. This lack of a coherent single biological process makes it hard to assign a concise, representative function to the cluster, so I label it Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006970","count":3},{"id":"GO:0005989","count":3},{"id":"GO:0098761","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0090557","count":2}]},{"hash":"1971865445498431326","title":"Embryonic Development and Morphogenesis","description":"Top GO terms cluster around placental differentiation, cartilage morphogenesis, left-right patterning, heart cushion formation, and endocrine system development, all pointing to embryonic tissue differentiation and morphogenesis. The lack of shared pathway connections (edges) suggests diverse roles within development rather than a single pathway, with a couple of generic terms likely reflecting background annotations.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0060972","count":4}]},{"hash":"1058046816570277276","title":"Sterol and fatty acid biosynthesis","description":"These proteins cluster around lipid and steroid biosynthesis: retinol metabolism, very long-chain fatty acid and mycolic acid biosynthesis, and estrogen/glucocorticoid biosynthetic pathways. A pigment biosynthesis term (melanin) appears among the top terms, but the dominant theme remains lipid/sterol metabolism and related pathways, suggesting a functional group centered on sterol and fatty acid production with ancillary pigment-related roles.","confidence":"Medium","size":17,"edges":110,"triangles":378,"max_degree":16,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042572","count":13},{"id":"GO:0046677","count":13},{"id":"GO:0030497","count":13},{"id":"GO:0042438","count":13},{"id":"GO:0006703","count":13}]},{"hash":"1739610617725797598","title":"Inhibitory synapse scaffolding and signaling","description":"The top GO terms cluster around inhibitory postsynaptic potential regulation, gephyrin and PSD-95 clustering, and postsynaptic density organization, pointing to a module of proteins coordinating inhibitory synapses (GABAergic/glycinergic) via scaffolding and receptor trafficking. Some terms are broader, but the dominant signal is inhibitory synapse architecture and function.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0097151","count":13},{"id":"GO:0097119","count":13},{"id":"GO:0031623","count":13},{"id":"GO:0042493","count":13},{"id":"GO:0042982","count":13}]},{"hash":"174105035181993189","title":"Craniofacial skeletal development","description":"The cluster shows strong signals for embryonic cranial skeleton morphogenesis, chondrocyte development, and skeletal muscle tissue development, along with cadherin-mediated cell\u2013cell adhesion, all core to craniofacial tissue formation and morphogenesis. Additional terms like dendritic spine development and IL-6\u2013mediated signaling suggest broader developmental and signaling roles, but the dominant theme points to skeletal/craniofacial development and adhesion during tissue formation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044331","count":2},{"id":"GO:0060996","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0002063","count":2}]},{"hash":"1100450923940856530","title":"Actin Cytoskeleton Remodeling and Rho GTPase Signaling","description":"The cluster is enriched for terms related to actin cytoskeleton organization, regulation of Rho/Rac GTPase signaling, and small GTPase-mediated transduction, plus processes involving cell motility and morphogenesis such as dendritic spine morphogenesis, radial glia migration, and endothelial lumen extension. This points to a cohesive function in actin dynamics controlled by Rho family GTPases, governing cytoskeletal remodeling and cell movement.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030036","count":3},{"id":"GO:0051497","count":3},{"id":"GO:0060997","count":3},{"id":"GO:0097498","count":2},{"id":"GO:0035024","count":2}]},{"hash":"1262546499793318072","title":"RNA processing and transcription regulation","description":"This cluster features GO terms centered on RNA metabolism and processing: transcriptional regulation by RNA Pol II; mRNA splicing via spliceosome (including cis splicing); mRNA export; mRNA capping; regulation of translational initiation; regulatory ncRNA-mediated gene silencing; and mRNA polyadenylation regulation. A couple of insect-development terms (larval cuticle development, motor neuron axon guidance) appear but are not dominant. Overall, the strongest signal is RNA maturation and gene-expression control.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0006446","count":2}]},{"hash":"806209284953825060","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitination and proteasome-mediated protein catabolism (ubiquitin-dependent proteolysis, SCF-dependent proteasomal pathways, polyubiquitination). This suggests a proteostasis-centric cluster centered on targeted protein degradation, with supporting links to cell cycle and stress response regulatory processes such as circadian rhythm, DNA replication control, DNA damage signaling, and stress-induced apoptosis.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0031146","count":12},{"id":"GO:0000209","count":11},{"id":"GO:0042752","count":10},{"id":"GO:0071276","count":10}]},{"hash":"1726156097285724790","title":"Eye development and morphogenesis","description":"The top GO terms are dominated by retina and camera-type eye development, embryonic eye morphogenesis, and related ocular morphogenesis processes, indicating the cluster centers on eye formation. While there are additional terms about transcriptional regulation and other organs, the strongest and most representative signal is eye development, justifying this label.","confidence":"High","size":17,"edges":97,"triangles":248,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0002087","count":9},{"id":"GO:0002076","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0048048","count":6}]},{"hash":"1467973081189033606","title":"Unknown","description":"The top GO terms are highly diverse (Wnt signaling, proteolysis, leukotriene biosynthesis, glutathione metabolism, ADP-ribosylation, cell cycle-associated chromatid cohesion, vasopressin secretion, hepatocyte apoptosis, multicellular organismal process), with no single cohesive function tying the proteins together. This suggests a heterogeneous cluster without a clear, shared biological role.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0006508","count":2},{"id":"GO:1901750","count":2},{"id":"GO:0006751","count":2},{"id":"GO:0006750","count":2}]},{"hash":"806765992902039105","title":"Developmental apoptosis and endocytosis","description":"The cluster is enriched for multicellular organism development and female gonad development, with supporting terms for apoptotic processes and extrinsic death receptor signaling, plus clathrin-dependent endocytosis and ERK pathway regulation. This suggests a cohesive theme of developmentally coordinated signaling that links cell fate decisions (apoptosis) with membrane trafficking and growth signaling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:1902043","count":3},{"id":"GO:0008585","count":3},{"id":"GO:0034446","count":3},{"id":"GO:0072583","count":2}]},{"hash":"1789718633370336812","title":"Endothelial inflammation and coagulation regulation","description":"These proteins show enrichment for inflammatory and vascular-related processes: negative regulation of TNF production, prostaglandin response, endothelial barrier regulation, and blood coagulation. While some terms are more divergent (circadian rhythm, smooth muscle contraction, cell wall catabolic process), the recurring theme centers on inflammation and vascular/coagulation control, supporting a label focused on endothelial inflammatory regulation and coagulation processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032720","count":6},{"id":"GO:0046960","count":5},{"id":"GO:0007596","count":5},{"id":"GO:1903141","count":5},{"id":"GO:0042752","count":5}]},{"hash":"1621489918837819280","title":"Actin-driven immune cell signaling and migration","description":"The cluster's top GO terms cluster around actin cytoskeleton dynamics (filopodium assembly, actin filament bundle assembly) and processes like cell migration and dendritic spine maintenance, with additional immune signaling involvement (B cell receptor signaling, T cell receptor signaling). This suggests a theme of actin remodeling linked to immune cell activation and movement.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0097062","count":2},{"id":"GO:0016477","count":2}]},{"hash":"1314675808108543650","title":"Immune-inflammatory response and coagulation","description":"The terms repeatedly point to inflammatory and immune processes (leukocyte migration, defense against bacteria, cytokine/chemokine regulation) together with coagulation (blood coagulation, complement activation, fibrinolysis) and vascular remodeling (angiogenesis, collagen turnover). This combination defines a cohesive cluster centered on immune/inflammatory signaling with coagulation and tissue remodeling.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":12},{"id":"GO:0007596","count":11},{"id":"GO:0051919","count":11},{"id":"GO:0002523","count":11},{"id":"GO:0050754","count":11}]},{"hash":"2056840803651169835","title":"Complement-driven inflammation and coagulation","description":"The dominant GO terms center on complement activation (classical and lectin pathways), defense against Gram-positive bacteria, response to lipopolysaccharide, leukocyte migration, and inflammation, paired with fibrinolysis and plasminogen activation, indicating coagulation\u2013inflammation cross-talk. Additional terms include regulation of angiogenesis and ANP-mediated blood pressure regulation, suggesting vascular remodeling and cardiovascular context during inflammatory responses. Together, these terms describe a cluster of innate immune activation with coagulation and tissue remodeling processes rather than a single signaling pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0003050","count":7},{"id":"GO:0002523","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0032496","count":7}]},{"hash":"720084235370948112","title":"Diverse Metabolic Biosynthesis and Catabolism","description":"These proteins are associated with a wide range of metabolic biosynthesis and degradation processes, spanning amino acid, vitamin, isoprenoid/secondary metabolite, and carbohydrate conjugate pathways. The absence of network edges suggests functional diversification rather than a single module, so a broad label capturing diverse metabolism best fits.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009086","count":5},{"id":"GO:0019433","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0009234","count":4},{"id":"GO:0017000","count":4}]},{"hash":"1247035306994791592","title":"TORC1-driven growth and translation control","description":"The dominant GO terms point to TORC1 signaling, phosphorylation, and the formation of the translation preinitiation complex, all indicating regulation of growth and protein synthesis. Supporting terms for multicellular growth and metabolism (amino acid salvage and threonine biosynthesis) further fit a growth/metabolic control theme, with mitotic cohesion reflecting cell-cycle regulation under growth signals. Together these suggest a cohesive TORC1-regulated growth and translation program.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0019509","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0009088","count":3},{"id":"GO:0016310","count":3}]},{"hash":"578609132027578393","title":"Lectin-mediated innate immunity","description":"The top GO terms cluster around innate immune recognition and activation via lectins, including complement activation through the lectin pathway, C-type lectin receptor signaling, phagocytosis, leukocyte recruitment, and response to fungal origin. While there are some developmental terms present, the strongest common theme is lectin-driven immune recognition and effector functions such as phagocytosis and basophil activation.","confidence":"High","size":16,"edges":51,"triangles":65,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001502","count":14},{"id":"GO:0071226","count":14},{"id":"GO:0001867","count":13},{"id":"GO:0051873","count":12},{"id":"GO:0072237","count":12}]},{"hash":"501528124316085869","title":"Cardiac conduction and heart muscle development","description":"The strongest signals in the GO terms point to cardiac electrical activity and heart muscle organization: regulation of heart rate by cardiac conduction, regulation of ventricular cardiac muscle cell action potential, and adhesion/organization related to Purkinje fibers and the bundle of His. While there are a few general terms (cell cycle, chromatin maintenance), they are less specific to this cluster\u2019s dominant function, so the label focuses on cardiac conduction and heart muscle development.","confidence":"High","size":16,"edges":97,"triangles":371,"max_degree":15,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":8},{"id":"GO:0010909","count":6},{"id":"GO:0048496","count":6},{"id":"GO:0070602","count":6},{"id":"GO:0072699","count":6}]},{"hash":"1777365063171225066","title":"Mitochondrial dynamics and cardiolipin metabolism","description":"This cluster is dominated by GO terms centered on mitochondrial function: mitochondrion inheritance, stress-induced mitochondrial fusion, inner mitochondrial membrane organization, and regulation of mitochondrial membrane potential, along with cardiolipin metabolism. While a few terms touch on broader processes (excretion, SREBP signaling, ECM disassembly, TLR3 signaling), the strongest and most recurrent themes are mitochondrial membrane dynamics and lipid homeostasis, suggesting proteins here coordinate mitochondrial structure and energy-related lipid regulation.","confidence":"High","size":16,"edges":33,"triangles":31,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":6},{"id":"GO:1990046","count":5},{"id":"GO:0007007","count":5},{"id":"GO:0010918","count":5},{"id":"GO:1900210","count":5}]},{"hash":"65185656655411093","title":"Spliceosome-driven RNA processing and translation control","description":"The cluster is dominated by spliceosome-related terms (mRNA splicing, regulation and alternative splicing) alongside terms tied to mRNA modification and translation initiation (formation of the preinitiation complex, regulation of translational initiation). This suggests a cohesive role in post-transcriptional gene expression, linking RNA maturation to initiation of translation.","confidence":"High","size":16,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":12},{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:0016556","count":11},{"id":"GO:1902625","count":11}]},{"hash":"338835935536590127","title":"Glycinergic Synaptic Transport and Monoamine Uptake","description":"The top GO terms emphasize glycinergic synaptic transmission and uptake (glycine) along with dopamine and serotonin uptake, plus transport of several amino acids. This points to a cohesive theme of neurotransmitter and amino acid transport at synapses, rather than a single metabolic pathway.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060092","count":2},{"id":"GO:0060012","count":2},{"id":"GO:0051583","count":2},{"id":"GO:0042066","count":2},{"id":"GO:1905847","count":2}]},{"hash":"2301119443273886281","title":"Mitochondrial Translation and Oxidative Phosphorylation","description":"The GO terms cluster strongly around mitochondria: mitochondrial translation; electron transport (NADH to ubiquinone); ATP synthesis coupled to electron transport; and proton transmembrane transport, indicating robust energy metabolism centered on mitochondria. There are also some translation and DNA biosynthetic processes, and vacuolar targeting/acidification terms, but they appear peripheral to the dominant mitochondrial respiration theme. The label reflects the core functions of the cluster.","confidence":"High","size":16,"edges":117,"triangles":519,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0071897","count":3},{"id":"GO:0006814","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0001300","count":2},{"id":"GO:0006412","count":2}]},{"hash":"994560243868227912","title":"Ribosome biogenesis and translation","description":"The top GO terms indicate ribosomal RNA processing and maturation (LSU/SSU), ribosomal subunit export, small subunit biogenesis, and core translation steps, including translation and initiation factor assembly. This combination strongly points to a cluster specialized in ribosome assembly and protein synthesis.","confidence":"High","size":16,"edges":50,"triangles":69,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0006370","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0000447","count":2}]},{"hash":"1977091241759458524","title":"Unknown","description":"The terms span insect development (larval cuticle), multiple catabolic pathways (cellulose, lactose, glucosinolate), redox/mitochondrial changes, and signaling, with no clear shared function linking all proteins. The cluster appears highly heterogeneous, making a concise, representative label unreliable.","confidence":"","size":16,"edges":25,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:1901874","count":1},{"id":"GO:0018401","count":1},{"id":"GO:0032364","count":1},{"id":"GO:0055114","count":1}]},{"hash":"1465436416362321280","title":"Autophagy and vesicle trafficking","description":"Top GO terms indicate autophagosome maturation, intralumenal vesicle formation, ubiquitination, and membrane remodeling, suggesting a coherent role in autophagy-related vesicle trafficking. Some terms (mitotic cell cycle, thermosensory behavior, dendritic spine development, potassium transport) may reflect broader contexts or secondary roles. Overall, the cluster appears tied to membrane dynamics and autophagic processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":2},{"id":"GO:0018279","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0070676","count":2},{"id":"GO:0051260","count":2}]},{"hash":"1476025315976272709","title":"Cardiac muscle development and sarcomere assembly","description":"These GO terms cluster around heart and muscle development and contractile apparatus formation (heart development, cardiac myofibril assembly, sarcomere organization, muscle cell fate specification), coupled with transcriptional regulation (DNA-templated transcription, regulation of transcription) and NFAT signaling (positive regulation of calcineurin-NFAT). While a few terms reflect broader developmental roles (antennal, photoreceptor development), the dominant signal is cardiac muscle differentiation and sarcomere assembly.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051533","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0042694","count":2},{"id":"GO:0007469","count":2}]},{"hash":"18612093568187903","title":"Actin Cytoskeleton Remodeling and Lamellipodium Formation","description":"The cluster is dominated by GO terms related to actin dynamics (actin cytoskeleton organization, actin filament polymerization, barbed-end capping) and protrusive structures (lamellipodium assembly/morphogenesis, ruffle formation) as well as dendritic spine morphogenesis, pointing to a cohesive theme of actin-driven remodeling and cell motility; a couple terms about xenobiotic transport and cisplatin response may reflect peripheral membrane-related processes but do not override the central actin-focused function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0072673","count":2},{"id":"GO:0030036","count":2}]},{"hash":"798189191506600575","title":"Eye and Neural Development","description":"The top GO terms cluster around retina development, embryonic eye morphogenesis, and nervous system\u2013related processes (inhibitory synapse assembly, neural regulation), suggesting proteins broadly coordinating ocular and neural developmental programs; other terms (placenta, osteoblasts, wound healing) are secondary, but the eye/neural theme dominates.","confidence":"High","size":16,"edges":112,"triangles":456,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0060041","count":7},{"id":"GO:0002087","count":6},{"id":"GO:0002076","count":6},{"id":"GO:0035470","count":6}]},{"hash":"1094325990003231929","title":"Neurodevelopment and axon guidance signaling","description":"The cluster is enriched for nervous system development, axon guidance, and signaling pathways (ROBO and Smoothened/Hedgehog), plus dopamine response and ERK cascade activity, pointing to a neural development and neuronal pathfinding theme. Some terms like spermatid development and mitotic cell cycle are broader, but the strongest cohesive signal is neural development and axon guidance. ","confidence":"Medium","size":16,"edges":22,"triangles":0,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007286","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0043552","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0035385","count":5}]},{"hash":"1067892237614994949","title":"Cell cycle and cytoskeletal remodeling","description":"The top GO terms cluster around cell division and cytoskeletal dynamics: cell cycle and mitotic processes (e.g., cleavage furrow ingression), and regulation of GTPase activity that modulates the cytoskeleton, along with membrane tubulation and cell migration. While a few terms touch on developmental contexts (chorion, spermatid differentiation), the dominant signal lies in division-related and cytoskeletal remodeling activities. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0060717","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0034379","count":1},{"id":"GO:0007289","count":1}]},{"hash":"1640096956833772909","title":"RNA Modification and Methylation","description":"The top GO terms cluster around methylation-based modifications, especially RNA-related ones: rRNA modification, guanine-N7 methylation, 7-methylguanosine mRNA capping, and tRNA wobble uridine modification. There are also several protein methylation terms (arginine methylation, N-terminal methylation, histone methylation), suggesting a broader role for methyltransferases. Together these indicate a functional group focused on RNA modification and general methylation processes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014075","count":2},{"id":"GO:0000154","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0090398","count":2}]},{"hash":"1402484517574097885","title":"Retroviral DNA Integration and Host Interaction","description":"This cluster shows strong emphasis on DNA recombination, DNA integration, DNA replication, and RNA-templated DNA biosynthesis, with GO terms explicitly referring to proviral latency and viral entry into the host nucleus. Together these point to functions related to retroviral or retroelement life cycles and their interaction with host DNA metabolism, rather than a single canonical cellular process. An outlier term for skeletal muscle fiber development may reflect multifunctional proteins or annotation noise. Overall, the dominant theme is retroviral DNA integration and host interaction.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0048741","count":4},{"id":"GO:1903704","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0075713","count":3}]},{"hash":"1917073988164256491","title":"Embryonic Development and Morphogenesis Regulation","description":"The cluster centers on developmental processes: axis formation (dorsal/ventral, left/right), placenta-related differentiation, cartilage morphogenesis, pancreatic development, and EMT in heart/tissue formation, with accompanying transcriptional regulation terms. This points to a set of proteins that regulate embryonic development and tissue specification through transcription control, making the label representative and specific.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0007311","count":2}]},{"hash":"1176058294915870304","title":"Mitochondrial energy production and fatty acid metabolism","description":"The cluster\u2019s top GO terms are dominated by energy production (ATP synthesis coupled electron transport) and lipid-associated metabolism (carnitine biosynthesis/metabolism, fatty acid catabolism, and fatty-acyl-CoA biosynthesis). Development-related terms like liver development and post-embryonic development appear but seem secondary to the core metabolic theme, suggesting tissue- or developmental-stage modulation of mitochondrial fatty acid metabolism. Confidence: High","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042773","count":2},{"id":"GO:0045329","count":2},{"id":"GO:0051793","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0006574","count":2}]},{"hash":"1606304280595023943","title":"Fatty acid oxidation and cell cycle regulation","description":"The top GO terms indicate substantial representation of lipid metabolism, specifically carnitine metabolic process and fatty acid beta-oxidation, alongside terms related to cell cycle progression and cytokinesis, as well as regulation of apoptosis and ubiquitination. This suggests the cluster may encompass proteins involved in metabolic states that influence cell growth, division, and survival, rather than a single narrow function. Therefore the label reflects a dual theme of energy metabolism linked to proliferation/survival signaling rather than a tightly defined process.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0019254","count":4},{"id":"GO:0033540","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0032465","count":3}]},{"hash":"2043144433269786450","title":"NF-\u03baB\u2013Ubiquitin Pathway and Immune Signaling","description":"This cluster is dominated by ubiquitin-proteasome\u2013related processes and immune signaling (B and T cell receptor pathways) with links to NF-\u03baB regulation. It also includes ER-stress\u2013induced apoptotic signaling and DNA damage checkpoint responses, suggesting a broader stress- and immune-response module; a few developmental terms may reflect gene pleiotropy rather than core function.","confidence":"Medium","size":16,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0032436","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0021766","count":4},{"id":"GO:0097324","count":4}]},{"hash":"1087366619058965387","title":"Embryonic development and organ morphogenesis","description":"The top terms cluster around developmental differentiation and organ formation, including placenta-related differentiation, left-right patterning, cartilage morphogenesis, endocrine system development, and EMT in heart development. Some RNA processing terms appear as background biology but do not contradict the core developmental theme, supporting a label for embryogenesis and organ morphogenesis.","confidence":"High","size":16,"edges":17,"triangles":1,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060972","count":3}]},{"hash":"14128199929111851","title":"Muscle contraction regulation and fiber-type switching","description":"Based on the GO terms, the proteins cluster around muscle biology: regulation of striated and smooth muscle contraction, muscle filament sliding, and the transition between fast and slow muscle fiber types. A couple of outliers relate to ribosome biogenesis/export and autophagy, but the predominant theme is regulation of muscle contraction and fiber-type switching, indicating a muscle-function\u2013focused cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":3},{"id":"GO:0010507","count":1},{"id":"GO:0034198","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0031444","count":1}]},{"hash":"59077822466779309","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045602","count":2},{"id":"GO:0006296","count":2},{"id":"GO:0061373","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0060707","count":2}]},{"hash":"883919614471441015","title":"Cytoskeleton remodeling and cell cycle control","description":"This cluster centers on actin cytoskeleton dynamics (Arp2/3-mediated nucleation, actin cortical patch assembly) and cell cycle regulation (centrosome duplication, G2/M transition), suggesting a cohesive theme of cytoskeletal remodeling coordinating cell division; additional terms related to nuclear mRNA processing/export and perinuclear tethering imply broader coordination between gene expression and division.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035041","count":2},{"id":"GO:0030511","count":2},{"id":"GO:0000001","count":1},{"id":"GO:0034314","count":1},{"id":"GO:0000147","count":1}]},{"hash":"1953084194402257451","title":"Neurovascular development and signaling","description":"The top GO terms point to neural development and sensory processing (layer formation in the cerebral cortex, synapse assembly, visual perception) alongside vascular processes (angiogenesis, blood pressure regulation). Additional terms highlight broad signaling pathways (adenylate cyclase\u2013activating GPCR signaling, protein phosphorylation) and responses that can link neural and vascular contexts (morphine response, macrophage chemotaxis). This combination suggests a theme of coordinated neurodevelopment with neurovascular signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021819","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3}]},{"hash":"555963979136136809","title":"Ubiquitin-Dependent Proteostasis and Signaling","description":"The dominant annotation is ubiquitin-dependent protein catabolic process, pointing to a core role in tagging and degrading proteins. Additional terms show regulation of signaling pathways and immune-related processes, with hints of mitochondrial dynamics and muscle development, suggesting these proteins influence cellular proteostasis that modulates signaling and immune responses rather than a single classic function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0071287","count":4},{"id":"GO:0090141","count":4},{"id":"GO:0090394","count":4},{"id":"GO:0006469","count":3}]},{"hash":"549508825224981041","title":"Mitochondrial energy production and proton transport","description":"The cluster is dominated by terms related to mitochondrial function and bioenergetics, including proton transmembrane transport, mitochondrial electron transport, and proton motive force-driven ATP synthesis, pointing to mitochondrial energy production as the core theme. A few other terms appear unrelated (developmental or immune-related) and may reflect annotation noise rather than a shared function. ","confidence":"High","size":16,"edges":18,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":2},{"id":"GO:0005989","count":2},{"id":"GO:0000746","count":2},{"id":"GO:0006627","count":2},{"id":"GO:1902600","count":2}]},{"hash":"1818145776653555757","title":"Diverse Solute Transporters","description":"The top GO terms cluster around transmembrane transport activities for a variety of substrates (nitrate, sugars like galactose and arabinose, sialic acid, sodium ions, 4-hydroxyphenylacetate) and related processes, suggesting a group of membrane transporter proteins with broad substrate specificity. The mention of cellular response to mechanical stimulus is present but secondary; overall, the common theme is membrane transport across membranes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0015757","count":3}]},{"hash":"2151022465361488772","title":"Developmental Processes and Signaling","description":"The top GO terms point to development-related functions (retina, skin, multicellular organism development) and regulation of growth signals (GTPase activity, protein autophosphorylation), suggesting a weakly cohesive theme around organismal development and associated signaling, despite some unrelated terms like polysaccharide catabolism or vacuole fusion that may reflect broader cellular roles in the cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000272","count":2},{"id":"GO:0042144","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0008284","count":2}]},{"hash":"930616262309381303","title":"Neuronal plasticity and ECM remodeling","description":"The top terms are dominated by neural functions (social behavior, visual learning, long-term memory, regulation of long-term neuronal synaptic plasticity) and neuronal survival aspects, indicating a core focus on neural development and plasticity. The inclusion of extracellular matrix disassembly, alongside osteoblast differentiation and amelogenesis, suggests ECM remodeling and developmental tissue remodeling as a shared context. A modest presence of glucose-response terms hints at metabolic signaling linked to this remodeling. Overall, the cluster seems to center on neural plasticity intertwined with ECM-associated remodeling and development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0043524","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0007616","count":2}]},{"hash":"1672302686672534411","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0036494","count":9},{"id":"GO:0034975","count":9},{"id":"GO:0006986","count":9},{"id":"GO:0006458","count":9},{"id":"GO:0045454","count":9}]},{"hash":"1776950985926083584","title":"RNA transcription and ribosome biogenesis","description":"This cluster is dominated by RNA-centric processes: transcription initiation (RNA Pol II), Pol III-driven tRNA transcription, rRNA maturation and processing, and ribosome biogenesis, with supporting signals from mRNA splicing regulation and ncRNA-mediated silencing. The combination suggests a cohesive module of RNA synthesis, processing, and ribosome assembly, with a minor association to development in the context of cranial skeleton morphogenesis.","confidence":"High","size":15,"edges":86,"triangles":299,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006367","count":4},{"id":"GO:0048701","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0042766","count":3}]},{"hash":"539740801734295406","title":"Viral entry, genome integration, and latency","description":"This cluster centers on virus-host interactions: entry into host cells, integration of viral DNA into the host genome, and establishment of proviral latency, plus associated processes like reverse transcription (RNA-templated DNA biosynthesis), DNA replication/recombination, and apoptosis modulation. The recurring viral-centric GO terms strongly suggest a cohesive theme around viral life cycle stages rather than general cellular functions.","confidence":"High","size":15,"edges":65,"triangles":118,"max_degree":13,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:1903704","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0006260","count":3}]},{"hash":"1387353683634276764","title":"Glycinergic Synaptic Transmission and Glial Growth","description":"The top GO terms point to nervous system signaling, especially glycinergic synaptic transmission and its regulation, complemented by a glial growth term (perineurial glial growth). Additional terms touch on thalamic development and neurotransmitter uptake, suggesting a broader CNS/neural support context, though several metabolic terms seem less specific. With no network edges, the strongest cohesive theme remains glycinergic neurotransmission and associated glial development, making this a reasonable, concise label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":5},{"id":"GO:0055114","count":3},{"id":"GO:0009228","count":3},{"id":"GO:0006098","count":3},{"id":"GO:0060092","count":3}]},{"hash":"1095328906807511493","title":"Developmental differentiation and chromatin regulation","description":"This cluster is enriched for terms related to developmental differentiation (megakaryocyte and erythrocyte differentiation) and neural development (cerebral cortex development, neuron projection extension), as well as chromatin-related regulation (histone demethylation, chromatin binding). Taken together, the proteins likely participate in controlling development and gene expression, with some noisy terms like fungicide response and redox processes not central to the cluster\u2019s core function.","confidence":"High","size":15,"edges":62,"triangles":120,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045654","count":10},{"id":"GO:0021987","count":9},{"id":"GO:0046886","count":9},{"id":"GO:0045648","count":9},{"id":"GO:0060992","count":9}]},{"hash":"63254975306138158","title":"Steroid and lipid hormone biosynthesis","description":"The top GO terms cluster around biosynthesis and regulation of signaling lipids and hormones, including retinoic acid, prostaglandins, and ecdysone, plus hormone-regulated processes (aldosterone-related blood volume) and development (retina vasculature, tongue muscle differentiation). This suggests a functional group focused on lipid/hormone biosynthesis and signaling, with some accompanying stress and inflammatory regulation.","confidence":"Medium","size":15,"edges":22,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042904","count":6},{"id":"GO:0001516","count":6},{"id":"GO:0035902","count":5},{"id":"GO:1900087","count":5},{"id":"GO:0019341","count":5}]},{"hash":"1917487675439245998","title":"Ribosome Biogenesis and Translation Machinery","description":"The top GO terms are dominated by translation and ribosome biology (translation, ribosome biogenesis, initiation/elongation/termination, cytoplasmic translation). Additional terms cover related mRNA processing (deadenylation-dependent decay) and selenocysteine incorporation, all pointing to the protein-synthesis apparatus and its regulation. A minor signal for glial proliferation is present but does not override the primary theme. Thus the cluster most representatively reflects ribosome function and translation.","confidence":"High","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0042254","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0045901","count":3},{"id":"GO:2000767","count":3}]},{"hash":"439350454190192838","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0048568","count":2},{"id":"GO:0061158","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1007288464662279368","title":"Neuronal mitochondrial energy metabolism and calcium handling","description":"The cluster shows strong enrichment for mitochondrial processes (electron transport chain, proton translocation, aerobic respiration, mitochondrial calcium import/regulation) and neural development cues (axonogenesis, substantia nigra development), pointing to mitochondria-driven energy production and calcium homeostasis in neurons. Some unrelated terms (e.g., cell cycle) appear less central, but overall the mitochondrial-neuronal theme dominates. ","confidence":"High","size":15,"edges":62,"triangles":97,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0034396","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0016540","count":2},{"id":"GO:0036444","count":2},{"id":"GO:0000278","count":2}]},{"hash":"2045334832891576516","title":"Neurodevelopment and embryogenesis","description":"The terms cluster around neural development (PNS neuron development, midbrain/forebrain patterning, neuronal lineage commitment) and early embryogenesis (primitive streak formation, fertilization), with additional morphogenesis signals, suggesting a developmental program with a neural emphasis rather than a single molecular function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0007626","count":7},{"id":"GO:0048935","count":7},{"id":"GO:0090009","count":7},{"id":"GO:0007338","count":7}]},{"hash":"1787750957792855326","title":"Vascular GPCR\u2013cAMP signaling and blood pressure regulation","description":"The top GO terms cluster around signaling pathways that control vascular tone and cardiovascular function: positive regulation of blood pressure, adenylate cyclase-activating GPCR pathways, and prostaglandin responses all point to mechanisms that modulate constriction, dilation, and endothelial function. Co-occurring terms for blood coagulation and endothelial barrier regulation reinforce a vascular context, while regulation of circadian rhythm suggests time-of-day modulation of these processes. The electron transport chain and intestine smooth muscle contraction terms may reflect broader metabolic or contractile capabilities, but they don\u2019t dominate the cluster\u2019s theme.","confidence":"Medium","size":15,"edges":8,"triangles":2,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0007190","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0046960","count":11}]},{"hash":"1362107288362318913","title":"ER lipid handling and membrane remodeling","description":"The cluster shows GO terms centered on lipid metabolism and ER-associated processes: GPI anchor metabolic process, myo-inositol transport, cholesterol homeostasis, protein retention in the ER lumen, and protein-lipid complex remodeling. These collectively point to membrane-associated lipid handling and ER quality control/remodeling. Some neural-development terms are present but do not outweigh the lipid/ER theme, so the label captures the predominant function of the group. ","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006505","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0009948","count":1},{"id":"GO:0034368","count":1},{"id":"GO:0006621","count":1}]},{"hash":"1735830893270191889","title":"Ubiquitin-Proteasome Regulation of Mitosis and Development","description":"The cluster centers on ubiquitination and proteasomal degradation (K11-linked ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process) together with mitotic cell cycle control (G2/M transition, mitotic cycle) and embryonic development, indicating a theme of regulated protein turnover coordinating cell division and development. Some enrichment for peroxisomal import and DNA repair suggests broader maintenance roles, but ubiquitin-mediated regulation of mitosis and development appears primary.","confidence":"Medium","size":15,"edges":103,"triangles":429,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070979","count":14},{"id":"GO:0031146","count":14},{"id":"GO:0000086","count":14},{"id":"GO:0000278","count":14},{"id":"GO:0001701","count":14}]},{"hash":"1280084478139807968","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0009088","count":2},{"id":"GO:0016310","count":2}]},{"hash":"843981206412591496","title":"Mitochondrial Metabolite Transport and Energy Regulation","description":"This cluster centers on transport of metabolites and nucleotides into or across the mitochondrial membranes (deoxynucleotides, pyrimidine nucleotides, alpha-ketoglutarate, ornithine). It is also linked to mitochondrial membrane potential and energy-related processes (adaptive thermogenesis, fatty-acid response, liver regeneration), suggesting a cohesive role in mitochondrial energy homeostasis. Note: one GO term is obsolete but the overall pattern remains transport- and metabolism-focused.","confidence":"High","size":15,"edges":18,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097274","count":9},{"id":"GO:0051881","count":9},{"id":"GO:0030302","count":9},{"id":"GO:0070542","count":9},{"id":"GO:1990845","count":9}]},{"hash":"989936869287734820","title":"Circadian-regulated endocrine and neural development","description":"The top GO terms point to circadian regulation of gene expression alongside tissue development across endocrine (pancreatic cell development) and neural lineages (oligodendrocyte and neuron fate specification, bronchiole development). There is also transcriptional control (RNA polymerase II) and hormonal signaling (thyroid and glucocorticoid). Together, these suggest a theme of developmental programs that are modulated by circadian and hormonal signals across endocrine and neural tissues, so a concise label focusing on circadian-regulated development in these contexts is appropriate.","confidence":"Medium","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032922","count":13},{"id":"GO:0031018","count":12},{"id":"GO:0006366","count":12},{"id":"GO:1904017","count":12},{"id":"GO:2000323","count":12}]},{"hash":"728792239747126194","title":"SCF-ubiquitin proteolysis in circadian and cell-cycle control","description":"The top GO terms point to ubiquitin-dependent protein catabolism driven by SCF ubiquitin ligases, with strong emphasis on circadian rhythm regulation and cell-cycle related processes such as DNA replication initiation and G1 checkpoint signaling. This suggests a cluster of proteins functioning in ubiquitin-mediated proteolysis that modulates both circadian clock components and cell-cycle progression. Some developmental terms appear broader but can reflect regulation of proliferation and maturation in developmental contexts, consistent with ubiquitin-regulated control of cell states.","confidence":"High","size":15,"edges":12,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":11},{"id":"GO:0042787","count":11},{"id":"GO:0042752","count":8},{"id":"GO:0030174","count":8},{"id":"GO:1902916","count":8}]},{"hash":"553367074639649692","title":"RNA processing and ribosome biogenesis","description":"Most top terms cluster around RNA metabolism and ribosome maturation: mRNA splicing, RNA methylation, and maturation of 5.8S and LSU rRNA. This points to nuclear RNA processing and ribosome biogenesis as the core theme, with a few terms related to development and vesicle transport likely reflecting broader cellular roles rather than a specific cluster function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043547","count":2}]},{"hash":"799623420522324069","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":3},{"id":"GO:0042952","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0006212","count":3},{"id":"GO:0019740","count":3}]},{"hash":"1635489244885531337","title":"Diverse primary metabolism","description":"The top GO terms collectively point to a variety of core metabolic processes, including carbohydrate (glycogen) and lipid (fatty acid oxidation) metabolism, isoprenoid and quinone biosynthesis (isoprenoid, menaquinone), choline catabolism, and photosynthesis-associated carbon metabolism (photorespiration, oxidative photosynthetic carbon pathway). This spread suggests proteins involved in multiple fundamental metabolic pathways rather than a single specialized function. Hence, a label like Diverse primary metabolism captures the overall theme. ","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0005978","count":3},{"id":"GO:0009854","count":3},{"id":"GO:0042426","count":2},{"id":"GO:0009234","count":2}]},{"hash":"603710639090381353","title":"Inflammation, coagulation, and tissue remodeling","description":"The top terms cluster around inflammatory leukocyte trafficking, complement and coagulation pathways, antimicrobial defense, and tissue remodeling (angiogenesis and collagen catabolism). This suggests a cohesive theme of innate immune activation linked to coagulation and wound remodeling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0007596","count":7},{"id":"GO:0051919","count":7},{"id":"GO:0002523","count":7},{"id":"GO:0050754","count":7}]},{"hash":"711359566531547974","title":"Transmembrane solute transporters","description":"The top GO terms indicate broad transmembrane transport of diverse substrates, including vitamins, xenobiotics, phosphate, nitrates/nitrites, arabinose, potassium, and even neurotransmitter loading into synaptic vesicles. This pattern points to a cluster of transporter proteins that move a variety of solutes across membranes, rather than enzymes targeting a single substrate. The inclusion of a vesicular neurotransmitter transport term also supports a general transporter/vesicular transport role. ","confidence":"High","size":15,"edges":26,"triangles":8,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":14},{"id":"GO:0006855","count":14},{"id":"GO:0042891","count":13},{"id":"GO:0035435","count":10},{"id":"GO:0071805","count":10}]},{"hash":"1400728649455011421","title":"Developmental signaling and patterning","description":"This cluster aggregates terms related to development of multiple organs and systems (heart, nervous, skeletal), together with cell signaling and receptor organization (receptor clustering, B cell receptor signaling, Rho signaling). The mixture points to a general developmental signaling/patterning program rather than a single process.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":3},{"id":"GO:0035234","count":3},{"id":"GO:0001736","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0007399","count":3}]},{"hash":"2053333127983901073","title":"Nervous system development and inner ear morphogenesis","description":"This cluster centers on neural development and sensory organ formation: myelination, axonal fasciculation, branching morphogenesis of a nerve, and synapse assembly, plus otolith morphogenesis and detection of sound. While innate immune and antiviral defense terms appear, the dominant signal ties to nervous system maturation and sensory function, including hearing-related processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0045087","count":2},{"id":"GO:2000172","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0045842","count":2}]},{"hash":"813501223197690416","title":"Lipid and steroid biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for lipids and steroids: fatty acid elongation, very long-chain fatty acids, mycolic acid biosynthesis, sphinganine metabolism, retinol metabolism, and steroid hormone biosynthesis (estrogen and glucocorticoid). While there is a broader regulation of transcription and a stress/antibiotic response term, the core signal centers on production and modification of lipid-based and steroid metabolites, indicating a function cluster around lipid and steroid biosynthesis pathways. ","confidence":"High","size":15,"edges":43,"triangles":36,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":13},{"id":"GO:0042572","count":12},{"id":"GO:0046677","count":12},{"id":"GO:0030497","count":12},{"id":"GO:0042438","count":12}]},{"hash":"515674090221560039","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035773","count":2},{"id":"GO:0071031","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0000398","count":1}]},{"hash":"2098662908935280479","title":"Embryonic placenta and organ morphogenesis","description":"The proteins cluster around developmental processes: placenta (trophoblast giant cell differentiation), cartilage morphogenesis, endocrine system development, left-right pattern formation, pancreatic cell development, and palate/roof of mouth formation, plus EMT in heart development. A couple of outliers (mRNA splicing and vitamin D biosynthesis regulation) may reflect broader gene regulation rather than core cluster function. Overall, the theme is embryonic organ and placental morphogenesis. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":11},{"id":"GO:0060806","count":11},{"id":"GO:0060536","count":11},{"id":"GO:0035270","count":11},{"id":"GO:0060972","count":11}]},{"hash":"696062307537637021","title":"Neural development and brain regionalization","description":"The cluster\u2019s top GO terms center on neural development and brain patterning, including commitment to neuronal cell type in the forebrain, cerebral cortex regionalization, axon target recognition, and synaptic depression. While there are a few broader developmental terms (pituitary, notochord, uro-genital development), the prevailing signals point to neural differentiation and brain region specification as the core theme, suggesting a cohesive neural development cluster rather than a random mix.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021902","count":3},{"id":"GO:0021796","count":3},{"id":"GO:0023019","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0060044","count":2}]},{"hash":"1773379863826528644","title":"Mitochondrial Transport and Energetics","description":"Based on the GO terms, the cluster centers on transporting various metabolites (hemes, nucleotides, amino acids, alpha-ketoglutarate) across membranes and into mitochondria, coupled with regulation of mitochondrial membrane potential and energy-related processes such as adaptive thermogenesis and fatty acid response. This points to a cohesive theme of mitochondrial transporters linked to energy metabolism, with a few peripheral terms. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015886","count":4},{"id":"GO:0097274","count":3},{"id":"GO:0051881","count":3},{"id":"GO:0030302","count":3},{"id":"GO:0070542","count":3}]},{"hash":"17446589047630163","title":"Developmental signaling and RNA processing","description":"The cluster combines RNA processing terms (mRNA splicing via spliceosome, mRNA transport) with developmental and signaling-related terms (multicellular organism development, skin development, cellular response to hypoxia, mitotic cell cycle, regulation of protein kinases and GTPase activity). This pattern suggests proteins that coordinate gene expression regulation with signaling pathways during development and tissue formation, including responses to environmental cues like hypoxia.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0000398","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0043588","count":4}]},{"hash":"426345086209626741","title":"Ciliary/centrosomal assembly and left-right morphogenesis","description":"The terms cluster around cilium assembly, intraciliary transport, and centrosome localization, with related developmental processes like left-right symmetry and facial morphogenesis, suggesting a cohesive role for ciliary/centrosomal biology in developmental patterning.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902017","count":1},{"id":"GO:0035735","count":1},{"id":"GO:0090267","count":1},{"id":"GO:0051642","count":1},{"id":"GO:0007368","count":1}]},{"hash":"1422874343288597150","title":"Sumoylation and oxidative stress response","description":"This cluster is dominated by terms related to protein sumoylation, oxidative stress response (response to hydrogen peroxide and ROS metabolism regulation), and PML body organization, suggesting a module focused on post-translational modification and cellular defense against stress, with supporting roles in protein stabilization and intracellular transport. Peripheral signals include muscle contraction and estradiol response, but they are less central to the core theme.","confidence":"Medium","size":14,"edges":70,"triangles":208,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":5},{"id":"GO:0042542","count":3},{"id":"GO:0030578","count":3},{"id":"GO:0032387","count":2},{"id":"GO:0050821","count":2}]},{"hash":"463681250922916162","title":"Microtubule dynamics and spindle organization","description":"This cluster is dominated by GO terms linking microtubule cytoskeleton dynamics to spindle-related processes, including plus-end directed sliding, mitotic/meiotic spindle elongation and orientation, and depolymerization in various contexts (axonemal, plus-end). While a few terms touch on broader cellular activities like root development or chloroplast movement, the strongest signal centers on microtubule-based organization and spindle control.","confidence":"High","size":14,"edges":46,"triangles":73,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":11},{"id":"GO:0030951","count":9},{"id":"GO:0000022","count":9},{"id":"GO:0035617","count":9},{"id":"GO:0031535","count":9}]},{"hash":"290400469103893979","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":76,"triangles":237,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":8},{"id":"GO:0031047","count":8},{"id":"GO:1901407","count":7},{"id":"GO:0000464","count":6},{"id":"GO:1904574","count":5}]},{"hash":"127420751503608339","title":"Translation Regulation and mRNA Decay","description":"Based on GO terms, the cluster is dominated by translation-related processes: translation in general (initiation, elongation, termination), positive regulation of translational elongation and cytoplasmic translation, and translational fidelity. The presence of selenocysteine incorporation ties to a specialized translation pathway, while deadenylation-dependent decay links to mRNA turnover. An outlier like glial cell proliferation may reflect incidental annotations, but the core signal is translation machinery and post-transcriptional regulation.","confidence":"High","size":14,"edges":10,"triangles":0,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0046677","count":5},{"id":"GO:0006415","count":4},{"id":"GO:0045901","count":4},{"id":"GO:0006413","count":4}]},{"hash":"1634600475632832129","title":"Diverse membrane transporters","description":"This cluster is enriched for GO terms describing transmembrane transport of a wide range of substrates (nitrate, sugars, ions, and related compounds) and vesicle loading, pointing to a group of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":14,"edges":37,"triangles":39,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":4},{"id":"GO:0042891","count":4},{"id":"GO:0015739","count":4},{"id":"GO:0015757","count":4},{"id":"GO:0035725","count":4}]},{"hash":"1436001823366221746","title":"Unknown","description":"The GO terms span vertebrate development (telencephalon development, neural tube closure, trachea formation), adaptive immune signaling (T cell receptor signaling, activated T cell proliferation), stress responses (ER stress\u2013related apoptosis, alkaline pH response), and symbiont-host interactions, with no clear single unifying function for the cluster. Confidence: None","confidence":"","size":14,"edges":88,"triangles":330,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0020021","count":14},{"id":"GO:0060440","count":14},{"id":"GO:0021537","count":14},{"id":"GO:0050852","count":14},{"id":"GO:0001843","count":14}]},{"hash":"323318905258870303","title":"Stress- and apoptosis-related signaling","description":"The top GO terms point to broad cellular stress responses (hypoxia, osmotic stress, xenobiotic/LPS) and multiple apoptotic pathways (neuron apoptotic process, intrinsic apoptotic signaling), along with DNA damage response and some general protein processing. This pattern suggests the proteins participate in stress- and apoptosis-related signaling across contexts, rather than a single specific function. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0015707","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0051402","count":2}]},{"hash":"1659888738218867174","title":"Neurotransmitter synthesis and signaling","description":"This cluster centers on GABA biosynthesis, neuropeptide signaling, and transmembrane transport of amino acids (glutamate, serine, threonine, D-aspartate), pointing to roles in neuronal communication and neurotransmitter handling. The presence of general transport and signaling cascade terms supports a theme of neurotransmitter production and signaling, with potential downstream effects on heart rate and cellular signaling.","confidence":"High","size":14,"edges":68,"triangles":154,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0051938","count":1},{"id":"GO:0055085","count":1},{"id":"GO:0032329","count":1},{"id":"GO:0009449","count":1}]},{"hash":"500250568233480129","title":"Adaptive Immunity Regulation and Lymphocyte Isotype Control","description":"Top terms point to negative regulation of T cell proliferation, lymphocyte differentiation, and inflammatory responses, along with regulation of Ig isotype switching (IgE/IgG) and modulation of NF-kappaB signaling. This suggests a cluster of regulatory proteins that balance adaptive immunity, affecting both T cell activity and antibody isotype decisions. Therefore, a label emphasizing adaptive immunity regulation and lymphocyte isotype control fits well.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048294","count":1},{"id":"GO:0042130","count":1},{"id":"GO:0045619","count":1},{"id":"GO:0048302","count":1},{"id":"GO:0031398","count":1}]},{"hash":"1627597075171535519","title":"Unknown","description":"The top GO terms span translation and tRNA aminoacylation as well as mitochondrial protein import, but also include lipopolysaccharide/ether lipid biosynthesis, ubiquinone biosynthesis (obsolete terms), and antibiotic response. This mixture does not reveal a single cohesive function for the cluster, so a precise label cannot be assigned.","confidence":"","size":14,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:1901006","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0008611","count":2},{"id":"GO:0055114","count":2}]},{"hash":"2189707386858700720","title":"Lipid biosynthesis and adipogenesis","description":"The cluster is enriched for lipid metabolism terms: cholesterol esterification, fatty acid biosynthesis (including monounsaturated fats) and sphingolipid pathways, plus white fat cell differentiation, all pointing to lipid biosynthesis and adipocyte-related processes. Some terms are obsolete or peripheral (e.g., tarsal gland development), but the core signal supports lipid metabolism/adipogenesis.","confidence":"High","size":14,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010873","count":5},{"id":"GO:0050872","count":5},{"id":"GO:0044130","count":5},{"id":"GO:0034435","count":5},{"id":"GO:0070542","count":5}]},{"hash":"762123507250092957","title":"Multitissue Development and Morphogenesis","description":"The top GO terms point to developmental processes across multiple tissues (neural tube closure, optic fissure closure, cardiac ventricle development, vasculogenesis, skeletal muscle development, pancreas development, uterus development) and include regulation of apoptosis, indicating broad tissue morphogenesis and cell survival roles rather than a single pathway. This broad developmental theme justifies a multitissue development label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900118","count":2},{"id":"GO:0003323","count":2},{"id":"GO:2000270","count":2},{"id":"GO:0010667","count":2},{"id":"GO:0001843","count":2}]},{"hash":"1493443215550867194","title":"Microtubule regulation in mitosis and neural development","description":"This cluster is dominated by GO terms tied to microtubule dynamics and mitosis (mitotic spindle assembly, mitotic cell cycle, actin filament depolymerization, regulation of microtubule polymerization, and protein localization to microtubule minus-ends), with additional neural development terms (olfactory nerve organization, cerebellar Purkinje layer morphogenesis, vagus nerve development). The common theme appears to be cytoskeletal (microtubule)\u2013driven processes that underpin both cell division and neural development, supporting a cohesive interpretation despite the mix of terms. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0030042","count":3},{"id":"GO:0031115","count":2},{"id":"GO:0021629","count":2}]},{"hash":"640846732640994716","title":"Cross-tissue Developmental Processes","description":"The top GO terms span diverse tissue-specific development (gonads, cervix, phloem, atrial muscle, neuron axonogenesis) plus general transcription, indicating a broad developmental/regulatory role across tissues rather than a single pathway.","confidence":"Medium","size":14,"edges":24,"triangles":15,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":9},{"id":"GO:0060067","count":7},{"id":"GO:0010088","count":7},{"id":"GO:0042789","count":7},{"id":"GO:0046013","count":7}]},{"hash":"1753129038349619754","title":"Embryonic development and organ morphogenesis","description":"The top GO terms cluster around differentiation and morphogenesis during embryonic development\u2014placenta/trophoblast differentiation, endocrine system development, left-right patterning, cartilage morphogenesis, pancreatic cell development, and EMT in heart-related structures\u2014suggesting a shared role in developmental differentiation and organogenesis. A few housekeeping processes (splicing, ribosomal export, RNA Pol II regulation) may be secondary or broad-acting components of these developmental programs, but the dominant signal is embryonic development and organ morphogenesis.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0060536","count":7},{"id":"GO:0060972","count":7}]},{"hash":"494345172644231612","title":"Multisystem Development and Differentiation","description":"The top GO terms point to developmental processes across multiple tissues (muscle, tooth, brain, retina) and include both differentiation and signaling pathways (e.g., SHH/SMO), indicating a broad developmental program rather than a single tissue-specific function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0042475","count":2},{"id":"GO:0045880","count":2}]},{"hash":"1818998531510124850","title":"Nucleolar Ribosome Biogenesis and Nuclear Export","description":"Top GO terms indicate ribosome biogenesis, nucleolar rRNA transcription by RNA polymerase I, and export of the ribosomal large subunit from the nucleus, suggesting the cluster mainly involves ribosome assembly and nucleolar processing. While a few other terms appear, the strongest and most frequent signals point to nucleolar ribosome biogenesis and nuclear export.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000009","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0042790","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0032088","count":1}]},{"hash":"1829489220015265211","title":"Nervous system and sensory organ development","description":"The cluster\u2019s top GO terms primarily point to nervous system development and sensory-related processes: peripheral nerve myelination, neuron-to-neuron signaling, and regulation of neurotransmitter release, with additional signals for eye morphogenesis and broader embryonic development of sensory structures. While other terms like placenta development or hair follicle maturation appear, the strongest signal centers on neural and sensory system development, suggesting this as the core theme for the cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048820","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0007270","count":1},{"id":"GO:0048712","count":1},{"id":"GO:0048485","count":1}]},{"hash":"151649974829468461","title":"Unknown","description":"The GO terms are highly diverse, including DNA replication, unfolded protein response, chaperone-cofactor-dependent refolding, ER stress\u2013related and apoptotic regulation, cell morphogenesis, karyogamy, and iron ion sequestration. This lack of a single cohesive theme suggests the proteins do not share a clear common function that can be succinctly labeled, so an Unknown label with None confidence is appropriate.","confidence":"","size":13,"edges":15,"triangles":4,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0034620","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0000902","count":2},{"id":"GO:1903382","count":2}]},{"hash":"1407626492639572292","title":"Actin-driven cytoskeletal remodeling and spine dynamics","description":"This cluster is dominated by terms for actin filament polymerization and dendritic spine morphogenesis, pointing to cytoskeletal remodeling and synaptic spine dynamics as the core shared function. Supporting terms about protein complex stability and membrane tubulation suggest broader, dynamic protein interactions, but the central theme appears to be actin-driven structural changes. Some outlier terms (immune response, peroxisome import) are less representative of the main function here.","confidence":"Medium","size":13,"edges":20,"triangles":9,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0061635","count":2},{"id":"GO:0060997","count":2},{"id":"GO:1903526","count":2},{"id":"GO:0030041","count":2},{"id":"GO:0002250","count":2}]},{"hash":"605429974667555","title":"Redox Homeostasis and MAPK-Immune Signaling","description":"The cluster is enriched for terms related to cellular redox balance and oxidant detoxification, and also shows multiple terms about negative regulation of MAPK/ERK signaling and T cell\u2013related immune pathways, including NK cell cytotoxicity. This pattern points to a group of proteins involved in maintaining redox homeostasis while modulating MAPK and immune signaling; some terms like erythrocyte homeostasis and spermatogenesis appear as ancillary cellular processes but do not dominate the theme. Overall, the label captures the core theme of redox control intertwined with immune signaling regulation.","confidence":"Medium","size":13,"edges":33,"triangles":24,"max_degree":9,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0045454","count":5},{"id":"GO:0035335","count":5},{"id":"GO:0042267","count":5},{"id":"GO:0098869","count":5},{"id":"GO:0070373","count":4}]},{"hash":"1741739329139869970","title":"ABA-Triggered Osmotic Stress and Inositol/PI Metabolism","description":"This cluster is enriched for abscisic acid signaling, hyperosmotic salinity response, inositol biosynthesis and phosphatidylinositol phosphate biosynthesis, suggesting regulation of osmotic stress through PI signaling and inositol pathways. The presence of cell wall organization and glycosylation GO terms points to secreted glycoproteins and cell wall remodeling components involved in stress responses.","confidence":"Medium","size":13,"edges":13,"triangles":1,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0016266","count":2},{"id":"GO:0071555","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0006021","count":1},{"id":"GO:0009738","count":1}]},{"hash":"1031263526066348696","title":"Embryogenesis and Placental Development","description":"The top GO terms cluster around trophoblast giant cell differentiation, placental development, endocrine system development, left/right pattern formation, cartilage morphogenesis, and pancreatic cell development, all pointing to embryonic organogenesis and placental formation. A couple of housekeeping processes (splicing, ribosome export, RNA Pol II regulation) are present but do not define the cluster. Overall, the group seems to reflect developmental programs in early embryogenesis and placental/organ formation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0060536","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0060972","count":8}]},{"hash":"13770278211041943","title":"Cell Cycle and Development Regulation","description":"The cluster shows strong representation of DNA replication, G1/S transition, and meiotic cell cycle terms, plus kinetochore localization, pointing to coordinated cell cycle control. Added developmental terms (mesoderm formation, Schwann cell development) along with transcription and proteasomal degradation/JNK signaling suggest linked regulatory roles in development and protein turnover. Overall, a core theme of cell cycle regulation intertwined with developmental processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032436","count":6},{"id":"GO:0046329","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0042220","count":6},{"id":"GO:0001707","count":6}]},{"hash":"2199961916131866814","title":"Ribosome biogenesis and translation","description":"This cluster centers on the protein synthesis machinery, with strong signals for translation, ribosome biogenesis, rRNA maturation, and ribosomal subunit assembly, plus mitochondrial translation and translational fidelity maintenance, indicating a cohesive theme around ribosome function and protein synthesis.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0042254","count":5},{"id":"GO:0000462","count":5},{"id":"GO:0006415","count":3},{"id":"GO:0046677","count":2}]},{"hash":"40744590611368501","title":"Neural development and signaling cluster","description":"The most coherent theme is neural development and synaptic maturation: substantia nigra development, regulation of dendritic spine development, and nerve branching morphogenesis point to neural patterning and connectivity. GPCR signaling and, to a lesser extent, T cell receptor signaling reflect broader cellular signaling roles that can accompany development, while hair follicle morphogenesis adds a general morphogenesis context. Overall, the strongest pattern centers on neural development with supporting signaling activity.","confidence":"Medium","size":13,"edges":11,"triangles":1,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071851","count":13},{"id":"GO:0050852","count":13},{"id":"GO:0010796","count":13},{"id":"GO:0007186","count":13},{"id":"GO:0060999","count":13}]},{"hash":"691119531789125227","title":"Small GTPase signaling and phosphorylation","description":"The cluster centers on GO terms for small GTPase\u2013mediated signal transduction and phosphorylation, including Ras pathway regulation and general phosphorylation events, with supporting immune signaling (T cell receptor signaling and IL-7 response) and cytoskeletal dynamics (filopodium assembly). Peripheral terms like cholesterol biosynthesis and uterus development appear less directly connected to the core theme.","confidence":"High","size":13,"edges":13,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0046835","count":2}]},{"hash":"1321754723717962227","title":"Insect cuticle formation and pigmentation","description":"The top GO terms highlight melanin biosynthesis from tyrosine and larval chitin-based cuticle development, along with cuticle pigmentation, pointing to processes that couple pigment production with exoskeleton formation in insects. Some terms (ER protein folding, redox homeostasis) are general cellular functions and may reflect housekeeping overlap, but the insect-specific terms support a cohesive theme around cuticle formation and pigmentation, with possible ties to social traits like caste and mating behavior in certain species.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":2},{"id":"GO:0034975","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0048067","count":1},{"id":"GO:0060179","count":1}]},{"hash":"2168996061225064223","title":"Unknown","description":"The only top GO term is larval chitin-based cuticle development (GO:0008363), which could point to insect cuticle formation, but with just one term and no clear shared function across all 13 proteins, there isn\u2019t a cohesive theme to name the cluster.","confidence":"","size":13,"edges":13,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"933419951925621745","title":"Neural development and synaptic regulation","description":"The top GO terms cluster around nervous system development and synaptic function (retina development, synapse organization, PSD-95 clustering, inhibitory postsynaptic potential, receptor internalization, amyloid precursor protein metabolism). These point to neural signaling and synaptic regulation as the core theme. Some terms like osteoblast development and cellulose catabolic process are outliers, possibly reflecting multi-function proteins or annotation noise, but the dominant signal is neuronal development and synaptic regulation.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002087","count":8},{"id":"GO:0002076","count":8},{"id":"GO:0060041","count":8},{"id":"GO:0050808","count":6},{"id":"GO:0097151","count":6}]},{"hash":"1668953739578228019","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070058","count":1},{"id":"GO:0051306","count":1},{"id":"GO:0045132","count":1},{"id":"GO:0007076","count":1},{"id":"GO:0010032","count":1}]},{"hash":"1923711430290728001","title":"Neural development with RNA processing and translation regulation","description":"The top GO terms include neuron projection development and myelin assembly, alongside RNA processing (spliceosome splicing) and translation initiation, plus TORC1 signaling and actin cytoskeleton remodeling. This mix suggests a neural development-focused cluster where RNA processing and translation control support neural differentiation and neurite dynamics, with broader cell-cycle and cytoskeletal processes also represented. ","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032288","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0090307","count":2}]},{"hash":"744742251465136648","title":"Inflammation and coagulation response","description":"The cluster is enriched for immune/inflammatory processes: defense against Gram-positive bacteria, leukocyte migration, complement activation, fractalkine production, and regulation of IL-8, along with coagulation and fibrinolysis control, suggesting a coordinated inflammatory and clotting response; a fatty acid biosynthesis term and transcriptional regulation are present but secondary, likely reflecting metabolic support and gene control within this program.","confidence":"High","size":13,"edges":22,"triangles":4,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0006633","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0007596","count":3}]},{"hash":"1425264212148689804","title":"Mitochondrial Protein Import and Energy Metabolism","description":"The cluster's GO terms center on mitochondrial inner membrane processes (protein insertion), aerobic respiration, and transport, indicating a mitochondria-focused role in protein handling and energy production. While there are also peroxisome autophagy and general transport terms suggesting broader organelle maintenance, the dominant signal is mitochondrial function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0072321","count":1},{"id":"GO:0050826","count":1},{"id":"GO:0006810","count":1}]},{"hash":"736101308804842937","title":"Kidney water balance and urine regulation","description":"The cluster is enriched for renal-related processes, including renal system development, renal water homeostasis, regulation of urine volume, and response to water deprivation, with prostaglandin D stimulus also tying to kidney function; while retinol and norepinephrine metabolism are broader, their presence may relate to systemic regulation and metabolic stress (methylglyoxal) responses, but the dominant theme is kidney function and water balance.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":10},{"id":"GO:0042415","count":10},{"id":"GO:0072001","count":10},{"id":"GO:0003091","count":10},{"id":"GO:0071799","count":10}]},{"hash":"947635786286853422","title":"Cytoskeletal remodeling and morphogenesis","description":"Based on the GO terms, the cluster centers on actin cytoskeleton dynamics and cell shape changes (filopodium and podosome assembly, cell morphogenesis, neutrophil chemotaxis), with developmental morphogenesis terms (imaginal disc-derived leg morphogenesis, cerebral cortex development) also present. Immune sensing (muramyl dipeptide response) can trigger cytoskeletal rearrangements in migrating/activated cells, further tying the terms together. Overall, the proteins likely participate in cytoskeletal remodeling and morphogenesis processes across development and immunity.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071225","count":1},{"id":"GO:0007480","count":1},{"id":"GO:0021987","count":1},{"id":"GO:0030593","count":1},{"id":"GO:0071802","count":1}]},{"hash":"2190792574033705907","title":"Unknown","description":"The GO terms mix cytokinesis and septation-related processes with imaginal disc morphogenesis, cell polarity, and immune/peptidoglycan response signals, indicating no single cohesive function tying all proteins together. Because of this heterogeneity, there isn't a clear, representative label that accurately captures the cluster\u2019s overall biology.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000910","count":1},{"id":"GO:0035206","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0000920","count":1},{"id":"GO:0007118","count":1}]},{"hash":"1603266610658899530","title":"Neural Development and Transcription Regulation","description":"The top GO terms emphasize DNA-templated transcription and neural development (neuron and nervous system development), implying transcriptional control of neural differentiation. Supporting terms like potassium ion transport and chemotaxis point to signaling and cellular movement relevant to neural development, with additional broader developmental signals. Overall, the cluster seems enriched for transcriptional regulators linked to neural development, justifying this label.","confidence":"Medium","size":12,"edges":27,"triangles":21,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0043433","count":5},{"id":"GO:0006813","count":5},{"id":"GO:0048666","count":4},{"id":"GO:0006935","count":4}]},{"hash":"321115093877943828","title":"Developmental morphogenesis and tissue growth","description":"The cluster is characterized by strong signals for multicellular development, tissue growth, neural tube closure, and skeletal/skin development, indicating a shared role in developmental morphogenesis. Some terms related to stress and immune response appear but are less central; overall the proteins likely participate in embryonic development and tissue formation.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0001843","count":6},{"id":"GO:0070059","count":6},{"id":"GO:0071276","count":6}]},{"hash":"1791799170014098196","title":"Metal Ion Transport and Calcium Homeostasis","description":"The top GO terms are dominated by metal ion transport (zinc, cadmium, copper) and intracellular calcium ion homeostasis, suggesting the core function of this cluster centers on managing metal ions and calcium balance. The other terms (lipopolysaccharide biosynthesis, P450 epoxygenase pathway, serine biosynthesis, stilbene catabolism, testosterone response) are present but less connected to the main theme, indicating they are peripheral in this cluster. The overall network connectivity supports a cohesive module around metal ion handling.","confidence":"Medium","size":12,"edges":62,"triangles":182,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0071577","count":4},{"id":"GO:0046272","count":4},{"id":"GO:0070574","count":4},{"id":"GO:0006825","count":4},{"id":"GO:0097755","count":4}]},{"hash":"9047992276909797","title":"Lipid and Amino Acid Biosynthesis","description":"Proteins in this cluster are enriched for lipid biosynthesis (sphingomyelin, sphinganine, fatty acid transport) and amino-acid\u2013related biosynthetic processes (tyrosine, phenylalanine) along with central metabolic steps (oxaloacetate, heme). This pattern suggests a cohesive role in constructing lipid and amino acid\u2013derived metabolites, with multiple biosynthetic pathways represented. Confidence: Medium","confidence":"","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006107","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0006686","count":3},{"id":"GO:0033585","count":3},{"id":"GO:0006783","count":3}]},{"hash":"1730097345665718190","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":52,"triangles":112,"max_degree":11,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0032496","count":5},{"id":"GO:0006189","count":5},{"id":"GO:0042853","count":5},{"id":"GO:0042572","count":4}]},{"hash":"1915681657556798060","title":"ROS generation and vascular/immune signaling regulation","description":"The cluster is enriched for oxidative stress-related GO terms (hydrogen peroxide biosynthesis and superoxide generation) and for regulation of key signaling pathways (negative regulation of VEGF receptor signaling, ERK/MAPK cascade, and T cell receptor signaling), along with terms related to retina homeostasis and mitochondrial membrane potential. This suggests a cohesive theme around reactive oxygen species production and the modulation of signaling pathways governing vascular, immune, and neural/retinal functions, justifying a label centered on ROS signaling and vascular/immune regulation.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050665","count":7},{"id":"GO:0042554","count":7},{"id":"GO:0001975","count":7},{"id":"GO:0002576","count":7},{"id":"GO:0030948","count":6}]},{"hash":"614049183497963428","title":"Wnt/Hippo Signaling in Differentiation and Cell Fate","description":"Top GO terms center on apoptotic process, keratinocyte differentiation, Wnt signaling, and Hippo signaling, with additional links to transcriptional regulation of ribosomal proteins and sphingolipid biosynthesis. This points to a cohesive module governing differentiation and growth control, where Wnt/Hippo pathways shape cell fate decisions while balancing survival and proliferation.","confidence":"High","size":12,"edges":34,"triangles":39,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006915","count":9},{"id":"GO:0030216","count":9},{"id":"GO:0090263","count":9},{"id":"GO:0060044","count":9},{"id":"GO:0035329","count":9}]},{"hash":"111304122874564859","title":"Ribosome Biogenesis and Nuclear Transport","description":"The cluster is dominated by GO terms for ribosome biogenesis, translation, and the nuclear transport of ribosomal components (ribosomal subunit assembly, ribosomal protein import/export, and NLS-bearing protein import), indicating a cohesive role in ribosome production and nucleocytoplasmic trafficking. While there are a few broader nuclear processes present (e.g., pre-replicative complex assembly and transcription regulation), the core theme clearly centers on ribosome assembly and transport. ","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0006267","count":2},{"id":"GO:0010197","count":2},{"id":"GO:0000027","count":2}]},{"hash":"782547183564807148","title":"Translation Initiation and mRNA Splicing Regulation","description":"The top GO terms point to translation initiation and reinitiation processes (formation of translation preinitiation complex, translation reinitiation, regulation of translational initiation) together with spliceosome-related mRNA processing (alternative/mRNA splicing via spliceosome, positive regulation of splicing) and mRNA modification. This suggests a cohesive theme of RNA metabolism and control of translation, rather than a single enzymatic function, justifying a label focused on RNA processing and translation regulation. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":3},{"id":"GO:0048026","count":2},{"id":"GO:0016556","count":2},{"id":"GO:1902625","count":2}]},{"hash":"726027992404131198","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":5,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006417","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0039702","count":2}]},{"hash":"570864301462348106","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0007608","count":2},{"id":"GO:0019236","count":2}]},{"hash":"747987747457147025","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":16,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006068","count":4},{"id":"GO:0002002","count":4},{"id":"GO:0015015","count":4},{"id":"GO:0030573","count":4},{"id":"GO:0000103","count":4}]},{"hash":"649210976479088963","title":"Unknown","description":"The terms span metabolism (one-carbon metabolism, folate biosynthesis, tRNA queuosine biosynthesis) and diverse signaling/immune responses (interferon, TNF, NO synthase) plus cardiovascular regulation signals. There isn\u2019t a single cohesive function uniting these terms, suggesting no clear cluster theme; thus Unknown with None is appropriate.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008616","count":2},{"id":"GO:0010460","count":2},{"id":"GO:0006730","count":2},{"id":"GO:0051000","count":2},{"id":"GO:0046654","count":2}]},{"hash":"10921534664948120","title":"Synaptic adhesion and plasticity","description":"The top GO terms repeatedly point to cell adhesion and adherens/tight junction components together with neuronal synapse features: dendritic spine morphogenesis, positive regulation of excitatory postsynaptic potentials, synapse structural plasticity, and long-term synaptic depression, all of which are governed by Rho signaling and cytoskeletal remodeling at synapses. While some terms also reference barrier functions, the strongest, coherent theme is adhesion-mediated organization and plasticity of synapses.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0090557","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0060997","count":2}]},{"hash":"1254878542292767545","title":"Muscle sarcomere organization and cardiac regulation","description":"The GO terms are dominated by muscle-related functions, including sarcomere organization and positive regulation of sarcomere organization, plus heart-rate regulation by epinephrine and vascular smooth muscle processes, pointing to a muscle-structure/cardiac function cluster. A few translation initiation and immune defense terms appear as outliers, possibly incidental annotations rather than core cluster biology. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0003065","count":2}]},{"hash":"24403246609247580","title":"Unknown","description":"The top GO terms span diverse processes across different kingdoms (animal development like trophoblast differentiation and forebrain development; plant processes like mucilage biosynthesis and secondary cell wall biogenesis) and general cellular processes (transcription, mRNA splicing, mitotic cell cycle, cytokinesis). There isn't a single cohesive biological function linking these terms, so a meaningful, specific cluster label cannot be established.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0005978","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0006351","count":2}]},{"hash":"266209840195716666","title":"Ubiquitin-Proteasome Regulation of the Cell Cycle","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes and polyubiquitination, including SCF-dependent proteasomal degradation, suggesting a core role in targeted protein turnover. Additionally, regulation of circadian rhythm and initiation of DNA replication, plus mitotic G1 checkpoint signaling, point toward cell-cycle control and DNA damage response. A couple of outliers (synapse assembly, arsenic response) are less representative but do not override the main ubiquitin-proteasome/cell-cycle theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0031146","count":8},{"id":"GO:0042752","count":8},{"id":"GO:0030174","count":7},{"id":"GO:1902916","count":7}]},{"hash":"383146071586636100","title":"Developmental morphogenesis and tissue remodeling","description":"The proteins in this cluster are linked to morphogenesis and remodeling across several tissues\u2014lung branching morphogenesis, intramembranous ossification and bone resorption, basement membrane disassembly, and neural precursor proliferation\u2014suggesting a unifying theme of developmental tissue remodeling. Some terms related to immune signaling and hormone response are present but appear peripheral to the central developmental remodeling pattern.","confidence":"Medium","size":11,"edges":22,"triangles":18,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001913","count":7},{"id":"GO:0097067","count":7},{"id":"GO:0045453","count":7},{"id":"GO:0010815","count":7},{"id":"GO:0060448","count":7}]},{"hash":"1126422036533282166","title":"Immune inflammation and coagulation pathways","description":"Most of the top GO terms cluster around immune system activation and inflammatory processes, including leukocyte migration in inflammatory response, fractalkine production, complement activation (classical pathway), and negative regulation of IL-8 production. Coagulation/fibrinolysis and collagen catabolic process also point to extracellular matrix remodeling during inflammation. While midbrain development and transcriptional regulation terms are present, the dominant signal is immune/inflammatory and coagulation-related pathways, suggesting the cluster reflects genes involved in inflammatory response and coagulation interactions.","confidence":"Low","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0035264","count":6},{"id":"GO:0007596","count":5},{"id":"GO:0051919","count":5}]},{"hash":"466445200650325946","title":"Redox Balance and Mitochondrial Electron Transport","description":"The top terms cluster around oxidation-reduction processes, redox homeostasis, and cellular detoxification, along with mitochondrial electron transport, suggesting a shared theme of redox control and energy metabolism. Some terms (photosynthesis, spermatogenesis, NK cell cytotoxicity) appear as outliers, possibly due to cross-species annotations or broad functional associations within the protein set. Overall, the dominant pattern supports a redox/mitochondrial function theme.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0030416","count":3},{"id":"GO:2000255","count":3}]},{"hash":"199846425431181654","title":"DNA replication, repair, and chromatin remodeling","description":"This cluster shows strong representation for DNA replication and nucleotide-excision repair, plus chromatin remodeling, indicating a functional group involved in genome maintenance and chromatin control during replication and repair. Additional terms on transcription termination and regulation of double-strand break repair support a broader role in genome integrity and DNA-binding regulation.","confidence":"High","size":11,"edges":10,"triangles":2,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006289","count":4},{"id":"GO:0043044","count":4},{"id":"GO:0006363","count":3},{"id":"GO:0000717","count":3}]},{"hash":"954868651134369910","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":42,"triangles":92,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":9},{"id":"GO:0000278","count":9},{"id":"GO:1905869","count":7},{"id":"GO:0072356","count":7},{"id":"GO:0035330","count":7}]},{"hash":"1661938475531559089","title":"Unknown","description":"The GO terms cover neuroendocrine secretion (vasopressin), vascular remodeling, chemokine production, temperature sensing, pain, and cardiac conduction. These functions do not cohere into a single identifiable process for this cluster, so a concise, accurate label cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030103","count":4},{"id":"GO:0071651","count":4},{"id":"GO:0097497","count":4},{"id":"GO:2000340","count":4},{"id":"GO:0098907","count":4}]},{"hash":"1508667397449910609","title":"mRNA processing and spliceosome activity","description":"The cluster is dominated by GO terms tied to post-transcriptional mRNA processing and splicing, including mRNA export from the nucleus, polyadenylation, spliceosome-mediated cis and alternative splicing, and even connections to the translation preinitiation complex. This coherence suggests a group of proteins that participate in mRNA maturation and the regulation of splicing, rather than distinct pathways. Some terms are marked obsolete, but their inclusion still points to the same functional core.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0006378","count":4},{"id":"GO:0045292","count":4},{"id":"GO:0048026","count":3},{"id":"GO:0016556","count":3}]},{"hash":"2061190067357931292","title":"Coagulation and fibrinolysis","description":"The proteins are strongly linked to blood coagulation and its regulation, including plasminogen activation and fibrinolysis, with terms like Factor XII activation and positive regulation of coagulation, pointing to a hemostasis-focused cluster. Some items (mRNA splicing, responses to lipopolysaccharide, smooth muscle migration) are less central and may reflect multifunctionality or annotation noise, but the dominant theme is coagulation and clot breakdown.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0051919","count":2},{"id":"GO:0032496","count":2}]},{"hash":"846662763525756100","title":"Developmental RNA-processing and gene regulation","description":"Top GO terms indicate a blend of RNA processing/modification (RNA guanine-N7 methylation, mRNA splicing) and epigenetic regulation (histone acetylation, protein monoubiquitination) coupled with developmental processes (gastrulation, neural tube closure, neuron apoptotic process) and cell division aspects (spindle orientation, meiotic regulation). This suggests a core theme of controlling gene expression and differentiation during development through RNA and chromatin-level processes, with a few non-core terms (immune response) present but less central. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036265","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0007369","count":3},{"id":"GO:0000132","count":3}]},{"hash":"1131993899511257973","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":3},{"id":"GO:0002250","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0007416","count":2},{"id":"GO:2000463","count":2}]},{"hash":"640963469152714567","title":"Embryogenesis and Organ Development","description":"These proteins are enriched for GO terms tied to embryonic development and tissue patterning, including trophoblast/placental differentiation, left-right patterning, primitive streak formation, and organogenesis (cartilage, pancreas, endocrine system, heart). The cluster appears to group genes involved in early development and subsequent organ formation rather than a single molecular function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060972","count":5}]},{"hash":"1583452696586061993","title":"Innate immune response and mitochondrial lipid metabolism","description":"The cluster shows immune-related GO terms (innate immune response, response to virus, cellular response to lipopolysaccharide) alongside mitochondrial/cholesterol processes (outer mitochondrial membrane organization, mitochondrial translocase assembly, cholesterol metabolic process). This pattern suggests a theme where innate immunity interfaces with mitochondrial function and lipid metabolism, supporting this label.","confidence":"Medium","size":11,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0009615","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0071222","count":2}]},{"hash":"404045413799639326","title":"Vertebrate embryonic development and organ morphogenesis","description":"The proteins cluster around multiple developmental programs\u2014somite formation, neural plate/floor plate development, heart outflow tract morphogenesis, lung vasculature, and sensory organ differentiation\u2014along with transcriptional regulation terms. This suggests a cohesive theme of vertebrate embryogenesis and organ morphogenesis, rather than a single tissue type or process.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0035881","count":8},{"id":"GO:0060426","count":8},{"id":"GO:0033504","count":8},{"id":"GO:0001756","count":8}]},{"hash":"462856012288450965","title":"Mitochondrial Translation and Energy Metabolism","description":"These proteins are enriched for mitochondrial functions, with strong signals for mitochondrial translation and tRNA transamidation, plus core energy pathways such as the TCA cycle and fatty acid catabolism. The presence of related terms like endoplasmic reticulum organization and developmental processes likely reflects broader or pleiotropic roles rather than a single, unified pathway. ","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":6},{"id":"GO:0009062","count":4},{"id":"GO:0019876","count":4},{"id":"GO:0007029","count":4},{"id":"GO:0070681","count":4}]},{"hash":"1247599368375027219","title":"Motor neuron development and axon guidance","description":"The cluster centers on neuronal development and axon navigation, with terms like lateral motor column neuron migration, peripheral nervous system neuron axonogenesis, motor neuron axon guidance, and dopaminergic neuron differentiation. Cell-matrix adhesion supports migration/guidance, reinforcing this theme. Some unrelated terms may reflect broader developmental annotations, but the dominant signal is motor neuron development and axon guidance.","confidence":"Medium","size":11,"edges":33,"triangles":48,"max_degree":9,"top_function":"wound healing","top_go_terms":[{"id":"GO:0097477","count":9},{"id":"GO:0070527","count":9},{"id":"GO:0048936","count":8},{"id":"GO:0007160","count":8},{"id":"GO:0008045","count":8}]},{"hash":"343829827103567733","title":"Unknown","description":"The top GO terms span disparate biology: floral development regulation, MHC class I biosynthesis, vestibulo-ocular reflex, mitochondrial depolarization, TNF production, VEGF signaling, GPCR signaling, redox regulation, myelination, and innate immune response. This lack of a cohesive functional theme across the cluster suggests no single representative function; thus cannot assign a meaningful label.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010080","count":2},{"id":"GO:0045345","count":2},{"id":"GO:0060007","count":2},{"id":"GO:0051901","count":2},{"id":"GO:0032760","count":2}]},{"hash":"1938667399115008864","title":"Drosophila Toll signaling in development and immunity","description":"The top GO terms are dominated by Toll signaling and DV axis specification in Drosophila, with additional immune-related signals (lipopolysaccharide signaling, response to virus) suggesting a dual role in embryonic development and innate immunity. While other terms (ER targeting, cholesterol metabolism) are more general, they do not override the central Toll- and DV-related theme. Confident that this label captures the core function of the cluster.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006465","count":1},{"id":"GO:0045047","count":1},{"id":"GO:0007311","count":1},{"id":"GO:0008063","count":1},{"id":"GO:0007157","count":1}]},{"hash":"349792270590050853","title":"Unknown","description":"The GO terms span plant floral development, neural signaling and development, immune responses, and miscellaneous regulatory processes, with no single cohesive function tying all terms together. Therefore a specific, representative label cannot be determined.","confidence":"","size":11,"edges":13,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010080","count":1},{"id":"GO:0060007","count":1},{"id":"GO:0051901","count":1},{"id":"GO:1900747","count":1},{"id":"GO:0007186","count":1}]},{"hash":"858548602347593310","title":"Inflammation and complement regulation with lipid metabolism","description":"The cluster\u2019s top GO terms cluster around inflammatory response and regulation of the complement system (including classical and lectin pathways), along with chemokine production and macrophage chemotaxis regulation. Additional terms point to lipid storage and triglyceride biosynthesis as well as angiogenesis, suggesting a broader theme of immune/inflammatory regulation intertwined with metabolic and remodeling processes. Thus a concise label is inflammation and complement regulation with lipid metabolism.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0010951","count":1},{"id":"GO:0001869","count":1},{"id":"GO:0010884","count":1},{"id":"GO:0001798","count":1}]},{"hash":"1776799941643763736","title":"Olfactory perception and pheromone detection","description":"The top GO terms cluster around smell and pheromone-related processes (sensory perception of smell, olfactory behavior, detection of pheromone, courtship behavior, detection of chemical stimulus involved in smell), indicating the proteins likely participate in chemical sensing and pheromone signaling. Some unrelated terms (e.g., antibiotic response, methionine salvage) appear as noise, but the dominant theme is olfactory/pheromone-related. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":1},{"id":"GO:0019509","count":1},{"id":"GO:0019284","count":1},{"id":"GO:0009088","count":1},{"id":"GO:0016310","count":1}]},{"hash":"723961414151792479","title":"Embryonic development and tissue differentiation","description":"The cluster is enriched for GO terms related to developmental processes across multiple tissues (placenta and trophoblast differentiation, endocrine system development, cartilage morphogenesis, left-right patterning, EMT in heart development, pancreatic cell development, etc.), indicating a general theme of embryogenesis and tissue specification. Some terms (splicing, ribosomal export) reflect common cellular processes, but the dominant signal is developmental differentiation and morphogenesis.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":8},{"id":"GO:0060707","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0060536","count":8}]},{"hash":"24288539850971255","title":"RNA processing and translation initiation","description":"The cluster is enriched for mRNA processing activities (splicing via the spliceosome, alternative splicing, polyadenylation, and mRNA modification) and regulatory links to mRNA stability, plus involvement in forming the translation preinitiation complex, indicating a post-transcriptional RNA processing and translational control module.","confidence":"High","size":10,"edges":38,"triangles":85,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0000398","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0016556","count":4}]},{"hash":"489125685065714343","title":"Vacuolar Transport and Ion Homeostasis","description":"The cluster centers on vacuolar processes (acidification, organization, and targeting to the vacuole) and ion handling (sodium and copper), along with energy-driven transport (proton motive force and ATP synthesis). This points to a cohesive theme of vacuolar trafficking coupled to ion homeostasis and proton-driven transport mechanisms, despite auxiliary terms like cobalamin biosynthesis appearing less connected.","confidence":"Medium","size":10,"edges":39,"triangles":80,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":3},{"id":"GO:0007035","count":3},{"id":"GO:0006623","count":3},{"id":"GO:0006626","count":3},{"id":"GO:0006814","count":3}]},{"hash":"1877657380211727729","title":"Methylation Machinery for Chromatin and rRNA","description":"This cluster is dominated by GO terms tied to methylation across proteins and RNAs\u2014histone H4-R3 methylation, arginine methylation, lysine dimethylation, and rRNA methylation/modification\u2014suggesting a core function in methylation-based regulation of chromatin and ribosomal components. Supporting terms related to one-carbon metabolism (cobalamin biosynthesis, polyamine biosynthesis) fit into the metabolic context that fuels methylation processes. While a few terms (like chlorophyll biosynthesis) are less directly connected, the overall signal centers on methylation machinery governing chromatin and ribosome biology.","confidence":"High","size":10,"edges":19,"triangles":10,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090398","count":6},{"id":"GO:0043985","count":6},{"id":"GO:0019919","count":6},{"id":"GO:0009236","count":6},{"id":"GO:0031167","count":6}]},{"hash":"1236355299153875058","title":"Retroviral integration and latency","description":"The top GO terms cluster around retroviral life cycle events: RNA-templated DNA synthesis (reverse transcription), DNA integration and recombination into the host genome, establishment of proviral latency, and viral entry/penetration into the host nucleus, with supporting notes on host interaction and suppression of RNA silencing. This combination strongly points to retroviral genome integration and latency as the shared function of this protein set.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0006310","count":6},{"id":"GO:1903704","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0075713","count":5}]},{"hash":"1734559393127689152","title":"Amino acid and lipid metabolism","description":"The cluster shows strong representation of catabolic pathways for amino acids (leucine, valine) and fatty acids (medium-chain, fatty-acyl-CoA biosynthesis), plus related lipid processes and membrane-associated transport, suggesting a bacterial metabolic module centered on amino acid and lipid handling. Some terms (e.g., liver development, dibenzothiophene catabolic process) appear unrelated noise, but the core theme is coherent.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006552","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0015991","count":3},{"id":"GO:0009103","count":3},{"id":"GO:0045329","count":3}]},{"hash":"1823478733074769409","title":"RNAi and Antiviral Response","description":"The cluster is enriched for miRNA processing and RISC complex assembly, plus translation and virus-related terms (response to virus, regulation of viral transcription, negative regulation of defense response to virus). The strongest signals point to RNA interference pathways and antiviral defense via RNA silencing, with some unrelated terms likely representing noise.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0046782","count":3},{"id":"GO:0035196","count":3},{"id":"GO:0045433","count":3},{"id":"GO:0035280","count":3}]},{"hash":"1193000690238133652","title":"Neuronal cell adhesion and synapse assembly","description":"The cluster is dominated by GO terms for cell-cell adhesion (heterophilic/homophilic), synapse assembly, and axon-related junction organization (paranodal/juxtaparanodal localization), pointing to neural connectivity and synaptic structure. Some peripheral terms exist, but adhesion and synapse organization are the core theme.","confidence":"High","size":10,"edges":15,"triangles":3,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":5},{"id":"GO:0021836","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0030913","count":4},{"id":"GO:0071205","count":4}]},{"hash":"1609294156726148099","title":"Neural development and brain morphogenesis","description":"The cluster is dominated by terms tied to brain and nervous system development, Hedgehog signaling (Smoothened), and dendritic spine development, pointing to roles in neural development and synaptic maturation. Other terms about morphogenesis and certain apoptosis annotations likely reflect broader developmental processes, but the core signal centers on neural formation and connectivity.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":10},{"id":"GO:0040032","count":10},{"id":"GO:0007224","count":10},{"id":"GO:0071701","count":10},{"id":"GO:0060999","count":10}]},{"hash":"2168609440133778130","title":"Axon guidance and synaptic development","description":"The cluster centers on neural connectivity processes: corpus callosum development, axonal fasciculation, and positive regulation of synapse assembly point to axon pathfinding and synapse formation, while long-term synaptic depression signals synaptic plasticity. Ubiquitination may reflect protein turnover needed for signaling in developing neurons, and the cellular responses to mechanical and hormonal stimuli could relate to activity-dependent remodeling. Overall, the terms coalesce around neuronal development and synaptic regulation rather than general metabolic processes.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0022038","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0016567","count":2}]},{"hash":"1467681746585764025","title":"Inflammatory mediator production and chemokine regulation","description":"This cluster is dominated by terms related to inflammation and chemokine signaling (production of inflammatory mediators, positive regulation of chemokine production) and includes related signaling controls (MAP kinase activity, adrenergic signaling). The presence of carbohydrate metabolism and chitin catabolic process may reflect broader metabolic involvement or inflammation-associated proteins with chitinase-like activity, but the core theme centers on inflammatory mediator generation and chemokine regulation.","confidence":"Medium","size":10,"edges":12,"triangles":0,"max_degree":7,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":7},{"id":"GO:0090197","count":6},{"id":"GO:0002532","count":6},{"id":"GO:0005975","count":6},{"id":"GO:0010519","count":2}]},{"hash":"1642385259339717891","title":"Embryonic organogenesis and tissue differentiation","description":"The GO terms cluster around broad developmental processes across multiple tissues (placenta, inner ear labyrinthine layer, pancreas, cartilage, heart EMT, left-right patterning, endocrine system development), suggesting proteins involved in general embryonic development and lineage specification rather than a single pathway. This supports a label focused on embryonic organogenesis and tissue differentiation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060711","count":2},{"id":"GO:0070072","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060536","count":1}]},{"hash":"347557177240773917","title":"Nicotine-Responsive Neural Signaling","description":"Most terms point to neural communication and nicotine-related signaling: behavioral response to nicotine; glycinergic synaptic transmission; GABA receptor clustering; serotonin receptor signaling; vestibulocochlear nerve development; and regulation of circadian sleep/wake cycles. A couple of terms appear as outliers (zinc ion response, chondrocyte morphogenesis) but do not override the central theme of neurotransmission and nicotine-associated signaling. Confidence in this label is High.","confidence":"","size":10,"edges":19,"triangles":13,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035095","count":9},{"id":"GO:0060012","count":9},{"id":"GO:0071294","count":9},{"id":"GO:0045188","count":9},{"id":"GO:0003428","count":9}]},{"hash":"160688074041221007","title":"Neural signaling and sensory perception","description":"The cluster is dominated by GO terms related to nervous system signaling and sensory processing: glycinergic synaptic transmission, GABA receptor clustering, and serotonin signaling point to neurotransmission; detection of mechanical stimuli and vestibulocochlear nerve development align with auditory/sensory pathways; nicotine and circadian sleep/wake regulation indicate CNS signaling and behavioral modulation. A zinc ion response can modulate synaptic activity, supporting a neural context, while a developmental term for cartilage morphogenesis may be a minor outlier. Overall, the proteins appear to be enriched for neural communication and sensory function, justifying this label.","confidence":"High","size":10,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":7},{"id":"GO:0035095","count":6},{"id":"GO:0060012","count":6},{"id":"GO:0071294","count":6},{"id":"GO:0045188","count":6}]},{"hash":"2112507227678161560","title":"Cilia-Associated Hedgehog Signaling","description":"The cluster\u2019s strongest links are to ciliary biology and Hedgehog signaling, with GO terms for the smoothened signaling pathway and non-motile cilium assembly. Additional terms for transport and glycosylation are present but likely secondary, seen alongside tissue-specific processes like lens development. Thus, the core theme appears to be cilia-related signaling, particularly involving the Smoothened/Hedgehog axis.","confidence":"Medium","size":10,"edges":7,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":1},{"id":"GO:1905515","count":1},{"id":"GO:0080144","count":1},{"id":"GO:0034488","count":1},{"id":"GO:0006488","count":1}]},{"hash":"2204595641845625650","title":"Unknown","description":"Top GO terms are highly heterogeneous: translation, mesoderm formation and in utero embryonic development, innate immune response and angiogenesis, plus metabolism and several obsolete annotations. This mix spans distinct contexts and organisms, with no single pathway tying the proteins together, so a concise, reliable label cannot be assigned.","confidence":"","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0001707","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0045087","count":2}]},{"hash":"1003486428852107172","title":"Neural development and epithelial barrier formation","description":"The top GO terms point to neural development and signaling (cochlea morphogenesis, vocalization behavior, synaptic vesicle targeting) alongside epithelial/vascular barrier and tight junction processes (establishment of endothelial intestinal barrier, bicellular tight junction assembly). While some terms touch on transport and signaling modulation, the common theme appears to be development and communication in neural tissues together with barrier/junction organization. Confidence: Medium","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":2},{"id":"GO:0015879","count":2},{"id":"GO:0070588","count":2},{"id":"GO:0090557","count":2},{"id":"GO:0070830","count":2}]},{"hash":"285009245635776394","title":"Starch and glycogen metabolism","description":"The top GO terms show both biosynthesis and catabolism of starch and glycogen, plus related polysaccharide metabolism (maltose, alpha-glucan, trehalose, sucrose), indicating a cohesive role in storage carbohydrate remodeling.","confidence":"High","size":10,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019252","count":5},{"id":"GO:0005980","count":5},{"id":"GO:0044245","count":5},{"id":"GO:0005978","count":5},{"id":"GO:0000023","count":4}]},{"hash":"367897287433812018","title":"Neural development and synaptic organization","description":"The top terms are dominated by neural-related functions such as synaptic vesicle targeting, synapse organization, and cochlea morphogenesis, with vocalization behavior also tying to neural activity. While several terms touch on barriers and immune signaling, the central cluster appears to reflect neural development and synaptic function, making this label representative. Confidence is moderate because a few terms point to non-neural processes. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":4},{"id":"GO:0071625","count":4},{"id":"GO:0015879","count":3},{"id":"GO:0090557","count":3},{"id":"GO:0070830","count":3}]},{"hash":"97416296597149108","title":"Viral DNA integration and latency","description":"This cluster is enriched for GO terms related to DNA recombination, replication, and integration, plus RNA-templated DNA biosynthesis and processes specifically describing proviral latency and viral entry into the host genome. The presence of host-symbiont interaction terms and apoptosis activation further supports a viral integration/latency theme as the overarching function.","confidence":"High","size":9,"edges":27,"triangles":45,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0042493","count":3},{"id":"GO:0006260","count":3},{"id":"GO:1903704","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1582971579525318399","title":"Hypoxia-responsive kinase signaling and cell cycle","description":"The cluster centers on stress-responsive signaling and cell proliferation, with strong signals for hypoxia response, positive regulation of kinase activities (autophosphorylation and serine/threonine kinases), and regulation of GTPase activity, along with mitotic cell cycle processes. While some terms relate to transcriptional regulation and mRNA transport, the dominant theme ties signaling regulation to cell cycle control under hypoxic stress.","confidence":"High","size":9,"edges":26,"triangles":40,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0051028","count":5},{"id":"GO:0031954","count":5},{"id":"GO:0043547","count":5}]},{"hash":"2113952207971033790","title":"Translation Regulation and Ribosome Function","description":"Most terms cluster around translation control: positive regulation of cytoplasmic translation, ribosome disassembly, translational initiation/elongation/termination, and mitochondrial translation elongation, indicating a cohort of proteins involved in ribosome activity and protein synthesis. Some terms reference stress or immune-related processes (response to antibiotic, viral process) and glial proliferation, but they appear peripheral to the core translation-focused signal, making \"Translation Regulation and Ribosome Function\" an appropriate label.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0045901","count":2},{"id":"GO:0032790","count":2},{"id":"GO:2000767","count":2}]},{"hash":"1804102609100405479","title":"Protein quality control and degradation","description":"The GO terms point to proteostasis mechanisms: deubiquitination, negative regulation of proteasomal degradation, aggrephagy, and ERAD-related maintenance of unfolded proteins, plus regulation of vesicle formation linked to autophagy pathways. While a couple terms touch on cell division or stress responses, the strongest signal is protein quality control via ubiquitin-proteasome and autophagy pathways.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1905366","count":8},{"id":"GO:0030474","count":8},{"id":"GO:1904378","count":8},{"id":"GO:1901799","count":8},{"id":"GO:0000753","count":8}]},{"hash":"824672659455787843","title":"Cell cycle regulation and mitosis control","description":"The top GO terms center on cell cycle control and mitosis (negative regulation of cyclin-dependent protein kinase activity, regulation of cell cycle, meiotic spindle disassembly, and positive regulation of mitotic sister chromatid biorientation), suggesting the cluster\u2019s core function is coordinating cell division. Additional terms involving apoptosis signaling, stress responses, and signaling modulation appear as secondary layers that may reflect pathway crosstalk or regulatory context rather than a distinct separate function. Overall, the dominant theme is cell cycle regulation with mitotic control as the defining label.","confidence":"Medium","size":9,"edges":32,"triangles":59,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":2},{"id":"GO:0051229","count":2},{"id":"GO:0043508","count":2},{"id":"GO:0071470","count":2},{"id":"GO:0071850","count":2}]},{"hash":"549714751103150325","title":"RNA export and translation initiation","description":"Reasoning: The terms cluster around mRNA export from the nucleus, formation of the translation preinitiation complex, various modes of translation initiation (including IRES-dependent), and translation reinitiation, with an additional note on SSU rRNA maturation. This suggests a cohesive theme of RNA processing/export together with initiation of protein synthesis and ribosome-related steps.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0075525","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0075522","count":3}]},{"hash":"1003725293300415045","title":"Bacterial quinone and lipid biosynthesis with teichoic acids","description":"The GO terms cluster around quinone biosynthesis (menaquinone, phylloquinone) and fatty acid biosynthesis/\u03b2-oxidation, plus teichoic and lipoteichoic acid biosynthesis and related D-alanylation. These points strongly suggest a Gram-positive bacterial metabolism focused on lipid/cofactor production and cell wall components, with antibiotic biosynthesis and certain catabolic terms as secondary signals. Confidence: Medium","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0009234","count":5},{"id":"GO:0006574","count":5},{"id":"GO:0006635","count":5},{"id":"GO:0042372","count":5}]},{"hash":"1603162748137298008","title":"Neuronal signaling and sensory processing","description":"This cluster centers on neuronal communication and sensory perception, with GO terms for GABA and glycinergic synaptic transmission, excitatory postsynaptic potentials, and ion transport, plus behavioral links like locomotion, taste aversion, and nicotine response, indicating a coherent theme of neuronal signaling underlying sensory processing and behavior.","confidence":"High","size":9,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":4},{"id":"GO:0001661","count":4},{"id":"GO:0007214","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0050910","count":4}]},{"hash":"265176732305827354","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033386","count":3},{"id":"GO:0045337","count":3},{"id":"GO:1901663","count":3},{"id":"GO:0051290","count":3},{"id":"GO:0015031","count":3}]},{"hash":"1896447442930787297","title":"Heart development and electrophysiology","description":"The top terms point to cardiac morphogenesis (left ventricle, outflow tract), SA node regulation, and cardiac hypertrophy, together with calcium signaling (SERCA-mediated Ca2+ release) and ion-channel clustering. This pattern suggests proteins coordinating heart development and electrophysiological function rather than generic development pathways.","confidence":"High","size":9,"edges":25,"triangles":24,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0098907","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0014808","count":5}]},{"hash":"345186520041657429","title":"mRNA splicing and translation initiation regulation","description":"The cluster is dominated by spliceosome- and splicing-related GO terms (positive regulation of mRNA splicing via spliceosome, mRNA splice site recognition, alternative mRNA splicing) alongside translation-related terms (formation of translation preinitiation complex, regulation of translational initiation, viral translational termination-reinitiation) and RNA-based regulatory processes (regulatory ncRNA-mediated gene silencing, mRNA modification). This points to a cohesive theme of RNA processing, particularly splicing, and control of translation initiation, making the label specific and representative.","confidence":"High","size":9,"edges":6,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0006376","count":6},{"id":"GO:0016556","count":5},{"id":"GO:1902625","count":5}]},{"hash":"706346212373881084","title":"RNA processing and translational control","description":"The cluster is dominated by GO terms related to post-transcriptional regulation, including miRNA- and ncRNA-mediated gene silencing, alternative and regulated mRNA splicing via the spliceosome, mRNA modification, and regulation of translational initiation, suggesting a cohesive role in RNA processing and control of translation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035278","count":3},{"id":"GO:0048026","count":2},{"id":"GO:0016556","count":2},{"id":"GO:1902625","count":2},{"id":"GO:1901407","count":2}]},{"hash":"603895813219430430","title":"Nuclear gene expression and chromatin regulation","description":"The top terms point to nuclear processes: spliceosome assembly, transcription (DNA-templated), mRNA export, SAGA complex localization, histone deubiquitination, and proteasome assembly, as well as DNA repair and maintenance of repeats. Together these suggest a cohesive theme around transcriptional regulation, RNA processing/export, and chromatin/DNA maintenance, with some additional developmental/contextual terms. Confidence: Medium","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000245","count":1},{"id":"GO:0072742","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0030447","count":1},{"id":"GO:0000724","count":1}]},{"hash":"2150343855237984167","title":"Unknown","description":"Insufficient GO term data to identify a shared function; the Top Terms are empty, and with only 9 proteins and modest connectivity there is no clear common theme to base a meaningful label on.","confidence":"","size":9,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[]},{"hash":"2020099290654692841","title":"Mitochondrial Import and Inner Membrane Insertion","description":"The dominant terms point to mitochondrial protein handling, especially targeting to mitochondrion and insertion into the inner membrane, suggesting a cluster of proteins involved in mitochondrial import and inner-membrane assembly. Other terms (peroxisome autophagy, metamorphosis, pheromone response, smell, social behavior) seem less related and may reflect broader or incidental annotations; the core theme is mitochondrial protein transport and inner-membrane insertion.","confidence":"Medium","size":9,"edges":15,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":3},{"id":"GO:0006810","count":2},{"id":"GO:0045039","count":2},{"id":"GO:0072321","count":2},{"id":"GO:0050826","count":1}]},{"hash":"1204423232470065380","title":"Glycoprotein glycosylation in development","description":"The terms are dominated by glycan biosynthesis and O-linked glycosylation (poly-N-acetyllactosamine, Lewis A, arabinogalactan protein metabolism) and by developmental processes across tissues (root hair development, insect visual primordium formation, follicle epithelium polarity/adhesion, seed mucilage). Together these point to a module of glycosylated surface/extracellular components that influence morphogenesis, across species. ","confidence":"Medium","size":9,"edges":12,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030311","count":2},{"id":"GO:0001744","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0010493","count":2},{"id":"GO:0007299","count":2}]},{"hash":"359096430894769678","title":"Chromatin modification and chromatid cohesion","description":"The top GO terms cluster around chromatin regulation, including subtelomeric heterochromatin formation, histone H4 acetylation, and centromeric mitotic sister chromatid cohesion, suggesting the proteins function in chromatin remodeling and chromosome segregation. A few terms (melatonin and arginine biosynthesis) are less related and may reflect annotation noise, but the core theme is chromatin modification and cohesion.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":8},{"id":"GO:0061606","count":7},{"id":"GO:0043967","count":7},{"id":"GO:0006041","count":7},{"id":"GO:0017198","count":7}]},{"hash":"762368178725860517","title":"Unknown","description":"The GO terms span diverse processes, including a bacterial biosynthetic pathway, cell division, neuronal dendritic spine morphogenesis, transcription and RNA processing, ubiquitination, signaling, and actin assembly, with no single cohesive function tying them together.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006397","count":2}]},{"hash":"1345730321577121622","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0019510","count":1},{"id":"GO:0006782","count":1},{"id":"GO:0055129","count":1}]},{"hash":"1096843991928314151","title":"Lipid Metabolism and Seed Development","description":"The cluster centers on fatty acid transport and metabolism (medium- and long-chain fatty acids, long-chain fatty acid import) and related lipid pathways (bile acid metabolism, acetyl-CoA biosynthesis), with seed-related processes (seed germination, seed coat development) indicating a lipid metabolism theme tied to plant development. Some terms like lipoteichoic acid and siderophore biosynthesis appear but likely reflect broader biosynthetic annotations rather than a distinct second function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009698","count":8},{"id":"GO:0070395","count":8},{"id":"GO:0001579","count":8},{"id":"GO:0010030","count":8},{"id":"GO:0010214","count":8}]},{"hash":"1402977804391878818","title":"Insect Developmental Differentiation","description":"The terms cluster around metamorphosis, wing and eye cell fate specification, and spermatid differentiation, indicating a cohesive insect developmental/differentiation theme. Other terms reference related signaling and cellular stress processes that can intersect development, but the dominant signal is developmental patterning.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007552","count":1},{"id":"GO:0034620","count":1},{"id":"GO:0038005","count":1},{"id":"GO:1904211","count":1},{"id":"GO:0048515","count":1}]},{"hash":"2224061130014583215","title":"Embryonic development and morphogenesis","description":"The proteins collectively show GO terms tied to developmental processes and organ formation, including cartilage morphogenesis, trophoblast differentiation (placenta), endocrine system development, roof of the mouth, and left-right patterning. While some items touch general cellular functions (mRNA splicing, ribosomal export, RNA Pol II regulation), the recurring theme is embryonic development and tissue morphogenesis, suggesting these proteins function in developmental patterning and organogenesis.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0060806","count":1},{"id":"GO:1903026","count":1}]},{"hash":"1238461889666620211","title":"Actin Cytoskeleton Remodeling and Migration","description":"The cluster is characterized by GO terms tied to actin cytoskeleton dynamics and cell movement, including actin cytoskeleton organization, filopodium assembly, Rac signaling regulation, and cell migration. Additional terms highlight adhesion-related spreading and downstream signaling (Ras, Rac) that coordinate motility. While some terms refer to immune signaling and insulin pathways, the dominant theme centers on cytoskeletal remodeling driving cell movement and substrate interaction.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098761","count":2},{"id":"GO:0046847","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0001865","count":2}]},{"hash":"2255117936680986207","title":"Nicotine-Responsive Synaptic Signaling and Circadian Regulation","description":"The Top Terms cluster centers on neuronal signaling and modulation, with clear emphasis on nicotine-related responses (behavioral response to nicotine, response to nicotine) and neuromodulatory pathways (serotonin receptor signaling, excitatory postsynaptic potential, glycinergic transmission). The presence of a circadian sleep/wake regulation term supports a broader theme of neuronal activity control across time of day. Some terms appear tangential (growth plate chondrocyte morphogenesis, vestibulocochlear development), but the dominant signal is nicotine-responsive synaptic communication and circadian regulation.","confidence":"High","size":9,"edges":10,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":5},{"id":"GO:0035095","count":4},{"id":"GO:0043524","count":4},{"id":"GO:0060012","count":4},{"id":"GO:0071294","count":4}]},{"hash":"470722602299139159","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0019236","count":1},{"id":"GO:0071031","count":1}]},{"hash":"1428932134866960705","title":"Unknown","description":"The top GO terms are highly diverse, spanning complement activation, angiogenesis, digestion, Wnt signaling, ANP-regulated blood pressure, vitamin D response, transcription, protein dephosphorylation, and skeletal muscle development. This lack of a single cohesive function makes it difficult to assign a specific label to the cluster; no clear common theme emerges across all proteins.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0007586","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0003050","count":2}]},{"hash":"238474969651156888","title":"Unknown","description":"This cluster contains a mix of disparate functions: larval chitin-based cuticle development, regulation of transcription and miRNA processing, neuronal plasticity and memory, and various developmental processes. There is no single cohesive theme binding these terms, so a specific, representative label cannot be assigned with confidence.","confidence":"","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0060316","count":1},{"id":"GO:0007114","count":1},{"id":"GO:2000678","count":1},{"id":"GO:0000742","count":1}]},{"hash":"97080035452470437","title":"Post-transcriptional RNA processing and translational regulation","description":"This cluster centers on RNA processing and translation control, including spliceosome-mediated splicing, mRNA modification, initiation complex formation, translational initiation regulation, and stress-responsive mRNA stability.","confidence":"High","size":8,"edges":14,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":4},{"id":"GO:0048026","count":2},{"id":"GO:0016556","count":2},{"id":"GO:1902625","count":2},{"id":"GO:0001731","count":2}]},{"hash":"171126175665395701","title":"Immune signaling and inflammatory regulation","description":"Most terms point to signaling pathways involved in immune activation and regulation of inflammation (T cell receptor signaling, TNF signaling, and C-type lectin receptor signaling; plus negative regulation of inflammatory response). The presence of protein deubiquitination and regulation of mRNA stability suggests additional post-translational and post-transcriptional control layers, common in activated immune cells. A few terms relate to cell cycle and metabolism, but the dominant theme is immune signaling and inflammatory modulation.","confidence":"Medium","size":8,"edges":24,"triangles":38,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":6},{"id":"GO:0031145","count":6},{"id":"GO:0033209","count":6},{"id":"GO:0061418","count":6},{"id":"GO:0002223","count":6}]},{"hash":"1164212468862392721","title":"Inflammation and coagulation with tissue remodeling","description":"The GO terms cluster around inflammatory and immune processes (leukocyte migration, complement activation, defense against Gram-positive bacteria, regulation of IL-8, fractalkine production) and coagulation/fibrinolysis, plus extracellular matrix remodeling (collagen catabolic process) and angiogenesis. Together these indicate a module coordinating innate immunity, blood clotting, and tissue remodeling; the chitin cuticle term appears as an outlier but does not redefine the group.","confidence":"High","size":8,"edges":9,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0007596","count":2},{"id":"GO:0051919","count":2},{"id":"GO:0002523","count":2},{"id":"GO:0050754","count":2}]},{"hash":"354609818025755541","title":"Viral genome integration and latency","description":"The GO terms cluster around viral entry into host cells, proviral latency establishment, DNA integration and recombination, viral penetration into the host nucleus, and RNA-templated DNA synthesis, with additional notes on suppression of host RNA silencing. Together these point to a function centered on viral genome integration, latency, and host genome manipulation, despite some noise from unrelated terms like flagellum organization. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0075732","count":3}]},{"hash":"1077829987725999625","title":"Translation initiation and splicing regulation","description":"These proteins show a clear enrichment for translation initiation processes (formation of translation preinitiation complex, translation reinitiation, regulation of translational initiation) alongside RNA processing/splicing terms (alternative mRNA splicing via spliceosome, positive regulation of mRNA splicing via spliceosome, mRNA modification). This points to a post-transcriptional regulation module that links translation initiation with spliceosome-mediated mRNA processing, hence the name.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0048026","count":3},{"id":"GO:0016556","count":3},{"id":"GO:1902625","count":3}]},{"hash":"1047737899982955402","title":"Nuclear import and NPC assembly","description":"This cluster is driven by GO terms for importing proteins bearing NLS into the nucleus (including ribosomal proteins) and assembling the nuclear pore complex, with supporting signals from desumoylation regulation and protein turnover. Together, these terms point to a cohesive set of nuclear transport machinery components, with some regulatory connections.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":4},{"id":"GO:0000060","count":4},{"id":"GO:0060188","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0051292","count":4}]},{"hash":"1740941361531149066","title":"Developmental morphogenesis and differentiation","description":"The GO terms are dominated by developmental and morphogenesis processes: larval chitin-based cuticle development, neuron migration, tube formation, myoblast differentiation, and establishment of cell polarity, with related references to centrosome cycle and DNA metabolism. Together these point to proteins involved in cellular differentiation and tissue morphogenesis rather than a single targeted pathway. A few terms related to lipid catabolism and immune signaling appear, but they are not defining for the cluster.","confidence":"Medium","size":8,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0001764","count":1},{"id":"GO:0030010","count":1},{"id":"GO:0035148","count":1},{"id":"GO:0007098","count":1}]},{"hash":"1416534414595575164","title":"Cellular stress responses and cell cycle control","description":"This cluster shows enrichment for GO terms tied to responding to diverse stresses (lipopolysaccharide, hypoxia, ATP), regulating apoptosis and DNA damage response, and coordinating cell cycle transitions (G0\u2192G1, mitotic checkpoints), as well as chromatin remodeling (nucleosome disassembly). While a couple terms relate to development or neural processes, the dominant theme is stress signaling and cell fate decisions through cell cycle and chromatin changes, supporting this label.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:1904719","count":1},{"id":"GO:0043066","count":1},{"id":"GO:0003139","count":1},{"id":"GO:0045023","count":1}]},{"hash":"1332286906370095653","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0045944","count":3}]},{"hash":"1780730714892461311","title":"Embryonic Organogenesis and Tissue Differentiation","description":"The top GO terms cluster around developmental processes and organogenesis in embryonic contexts\u2014placental differentiation, left-right patterning, cartilage morphogenesis, pancreatic cell development, endocrine system development, and EMT in heart/cardiac cushion formation\u2014suggesting a theme of lineage specification and tissue formation rather than a single biochemical activity. Some terms (e.g., ubiquitin-dependent catabolism, rDNA maintenance) are general cellular processes that accompany development but do not alter this main theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2}]},{"hash":"2068687320664559681","title":"Steroidogenesis and cholesterol transport","description":"Based on GO terms, the cluster is centered on lipid metabolism and steroid-related pathways, with emphasis on intracellular cholesterol transport and androgen metabolism, and supported by Sertoli cell development signals. Lipid handling is further reflected by medium- and very-long-chain fatty-acyl-CoA metabolic processes and lipid hydroperoxide transport. A couple of terms about cell division are more general and do not define the cluster; overall the dominant theme links steroid biosynthesis with lipid transport in a male reproductive context.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032150","count":2},{"id":"GO:0036112","count":2},{"id":"GO:0032385","count":2},{"id":"GO:1901373","count":2},{"id":"GO:0060009","count":2}]},{"hash":"1268622768188006254","title":"Diverse solute transmembrane transport","description":"The Top Terms are dominated by transmembrane transport of diverse substrates (nitrate, sugars, ions, and related compounds), indicating a shared membrane transport function across multiple substrates. A lactose biosynthesis term appears but does not alter the overall transport-oriented theme.","confidence":"High","size":8,"edges":17,"triangles":14,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":8},{"id":"GO:0043252","count":8},{"id":"GO:0042128","count":8},{"id":"GO:0070715","count":8},{"id":"GO:0052106","count":8}]},{"hash":"122702747108105312","title":"Starch and glycogen metabolism","description":"Most top GO terms point to carbohydrate metabolism, especially starch, amylopectin, glycogen, and trehalose biosynthesis/catabolism, indicating a cluster of proteins involved in carbohydrate storage and processing. The single outlier term about myelination is likely noise; overall the cluster is best described as starch/glycogen metabolism.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022011","count":2},{"id":"GO:0000023","count":2},{"id":"GO:0010021","count":2},{"id":"GO:0005985","count":2},{"id":"GO:0019252","count":2}]},{"hash":"833913624758277785","title":"Spermatogenesis and Acrosome Assembly","description":"This cluster is best described by the strong enrichment for acrosome assembly and sperm axoneme assembly, both core to male germ cell development and fertilization. Supporting terms about lipid metabolism and proteasomal degradation hint at membrane remodeling and protein turnover processes that accompany spermatogenesis and acrosome formation. Some placental development terms may reflect broader developmental annotation or noise, but the dominant signals point to sperm development and acrosome-related functions.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":2},{"id":"GO:0019372","count":2},{"id":"GO:0016042","count":2},{"id":"GO:0001675","count":2},{"id":"GO:0043303","count":2}]},{"hash":"1648966273356603239","title":"Membrane amino acid and polyamine transport","description":"Most terms describe transport of amino acids across the plasma membrane (L-ornithine, methionine, arginine, lysine, D-alanine) and polyamine or ammonium transport, along with cell volume homeostasis, which together point to membrane transport activity; 'face morphogenesis' appears as an outlier and NO production terms may reflect signaling linked to inflammation rather than core transport.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0097640","count":1},{"id":"GO:0044690","count":1},{"id":"GO:1902269","count":1},{"id":"GO:0006527","count":1}]},{"hash":"1272643935217391079","title":"Peroxisomal matrix protein import","description":"The top GO terms are dominated by protein import into the peroxisome matrix (docking, translocation) and targeting to the peroxisome, indicating a cohesive function in peroxisomal protein import machinery; a related term about microtubule-mediated peroxisome transport supports the localization aspect but is secondary.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036250","count":1},{"id":"GO:0006625","count":1},{"id":"GO:0044721","count":1},{"id":"GO:0032091","count":1},{"id":"GO:0016560","count":1}]},{"hash":"1091773148394249974","title":"Adaptive immune cell differentiation and signaling","description":"The GO terms are dominated by immune system processes: T cell selection, cytotoxic T cell differentiation, B cell differentiation, NK cell tolerance, Fc-gamma receptor signaling in phagocytosis, and classical complement activation. Together these point to development and activation of adaptive immune cells and their signaling pathways, with a few peripheral terms like angiogenesis or neurogenesis likely representing broader or off-target annotations. This naming captures the core functional theme of the cluster.","confidence":"High","size":8,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045058","count":1},{"id":"GO:0045765","count":1},{"id":"GO:0001923","count":1},{"id":"GO:0038096","count":1},{"id":"GO:0045065","count":1}]},{"hash":"1254847447471877501","title":"Unknown","description":"The listed GO terms span very different biological areas, including transport, pheromone/smell-related signaling, social behavior, various catabolic and biosynthetic processes, and protein turnover. With no unifying function or pathway tying the majority of terms together, there isn\u2019t a coherent theme to name the cluster beyond Unknown.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0019236","count":1},{"id":"GO:0018189","count":1}]},{"hash":"1352181203203661763","title":"Glycosaminoglycan and proteoglycan biosynthesis","description":"These proteins show dominant GO terms for the biosynthesis of proteoglycans and their glycosaminoglycan (GAG) chains (heparan sulfate, chondroitin/dermatan sulfate), indicating a coherent function in assembling extracellular matrix components. Though a few terms are peripheral or obsolete, the core signal is strong and points to GAG/proteoglycan biosynthesis and related ECM localization. ","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":1},{"id":"GO:0030208","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0015768","count":1},{"id":"GO:0033037","count":1}]},{"hash":"935807708249793011","title":"Viral entry, integration, and latency","description":"The set of GO terms centers on steps of viral infection and proviral maintenance: entry into host cells, integration of viral DNA, and establishment of integrated proviral latency. Additional terms point to viral replication/recombination and RNA-templated DNA biosynthesis, with some host immune responses such as apoptosis and complement activation. Taken together, the cluster seems to capture a module of viral genome processing and host manipulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903704","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0006260","count":2}]},{"hash":"205772178604248448","title":"Plant cell wall biosynthesis and glycosylation","description":"Enriched terms cluster around plant cell wall construction and modification, including secondary cell wall biogenesis, homogalacturonan and glucuronoxylan biosynthesis, mucilage production, and O-linked glycosylation of wall-associated proteins. This points to proteins involved in building and decorating plant cell walls, with carbohydrate metabolism terms supporting biosynthetic supply; a single outlier (skeletal muscle tissue regeneration) appears to be annotation noise and does not alter the overall theme.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010192","count":1},{"id":"GO:0043403","count":1},{"id":"GO:0009834","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0010289","count":1}]},{"hash":"339637266262710292","title":"Osteoimmunology signaling","description":"The proteins point to immune signaling (innate immune response, T cell receptor signaling, response to interleukin-7) alongside bone development cues (osteoblast fate commitment, PDGF receptor signaling). This combination suggests cross-talk between the immune system and bone formation, i.e., osteoimmunology. Cytoskeletal remodeling terms like filopodium assembly also align with immune cell movement and bone-resorbing cell dynamics, reinforcing a cohesive theme of immune\u2013bone coupling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0098761","count":2},{"id":"GO:0045794","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1098541560990851179","title":"Diverse biosynthesis of sugars, lipids, and pigments","description":"The top GO terms indicate a broad range of biosynthetic and metabolic activities, including sugar metabolism (galactose catabolic and GDP-mannose pathways), lipid metabolism (long-chain fatty-acyl-CoA), and various secondary metabolite/polysaccharide biosynthesis (anthocyanin, phenylpropanoid, wax, colanic acid, poly-hydroxybutyrate). There isn\u2019t a single cohesive function but a general theme of metabolite biosynthesis across multiple pathways, suggesting a diverse metabolic cluster rather than a specific pathway. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042619","count":7},{"id":"GO:0009718","count":5},{"id":"GO:0010025","count":5},{"id":"GO:0009699","count":5}]},{"hash":"742982400895054136","title":"RNA processing and translation regulation","description":"This cluster centers on post-transcriptional control: splicing (via spliceosome), mRNA modification and stability, alternative splicing, and multiple aspects of translation initiation/termination regulation, plus ncRNA-mediated gene silencing. These linked processes point to coordinated RNA processing and translation control rather than a single enzyme or pathway. ","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0016556","count":4},{"id":"GO:1902625","count":4},{"id":"GO:1901407","count":4}]},{"hash":"642259650815850373","title":"Ubiquitin-like modification pathways","description":"The proteins in this cluster are strongly associated with processes that attach ubiquitin-like modifiers (neddylation, sumoylation, ufmylation, urmylation) and related protein lipidation, pointing to a cohesive theme of post-translational modification by ubiquitin-like systems. Additional GO terms for tRNA wobble uridine thiolation and related RNA modifications appear, but the dominant signal remains ubiquitin-like modification pathways, making this a coherent functional cluster. The defense-related term may reflect regulatory cross-talk between stress responses and PTMs. ","confidence":"High","size":7,"edges":11,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0002143","count":5},{"id":"GO:0061504","count":5},{"id":"GO:0006501","count":5},{"id":"GO:0050832","count":5},{"id":"GO:0045892","count":5}]},{"hash":"609460136003106701","title":"Actin Cytoskeleton and Cell Polarity","description":"The top GO terms cluster around actin-based processes and cell shape control, including actin cortical patch assembly, actomyosin contractile ring contraction, and establishment/maintenance of cell polarity, with related processes like vacuole inheritance and multidimensional cell growth. Some terms seem less directly related (retina homeostasis, aggressive behavior), but the dominant signal is cytoskeletal organization and polarity, suggesting this cluster reflects actin dynamics and polarity regulation.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001895","count":2},{"id":"GO:0002121","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0043486","count":2},{"id":"GO:0048741","count":2}]},{"hash":"1673501803980522961","title":"Unknown","description":"The top GO terms span diverse processes (cell division, peroxisomal import, DNA repair, viral replication, development, and energy metabolism) with no single unifying function. Because no clear theme connects them, a specific label cannot be confidently assigned, so the cluster is Unknown.","confidence":"","size":7,"edges":14,"triangles":16,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0016558","count":4},{"id":"GO:0030420","count":4},{"id":"GO:2001171","count":4},{"id":"GO:1903862","count":4}]},{"hash":"1925438185246247161","title":"Ribosome Biogenesis and Translation","description":"Dominant GO terms center on ribosome function and translation\u2014translation, translational termination, ribosome biogenesis, ribosome disassembly, and ribosomal export\u2014pointing to a cluster of ribosome assembly and protein synthesis components. A few terms about transcriptional regulation and antibiotic response appear but do not define the cluster.","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0006415","count":1},{"id":"GO:0051301","count":1}]},{"hash":"1179014119203156731","title":"Metal ion transport and homeostasis","description":"The cluster is enriched for GO terms involving transmembrane transport and homeostasis of multiple metal ions (Na+, K+, Zn2+, Mn2+, Cd2+) and calcium release, pointing to a shared function in maintaining intracellular ion balance and membrane potential.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010107","count":3},{"id":"GO:0086009","count":3},{"id":"GO:0006883","count":3},{"id":"GO:0071577","count":3},{"id":"GO:1901205","count":3}]},{"hash":"395978995897435261","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0010323","count":1},{"id":"GO:0070935","count":1},{"id":"GO:0016120","count":1}]},{"hash":"246759340402176013","title":"Ribosome Biogenesis and Translational Initiation","description":"This cluster is dominated by GO terms related to ribosome assembly and initiation of translation: ribosome biogenesis, formation of translation preinitiation complex, regulation of translational initiation, translation reinitiation, and SSU rRNA maturation, including IRES-dependent viral translation. Some vesicle transport terms point to cellular contexts where protein synthesis intersects with ER-Golgi trafficking, but the core signal is ribosome assembly and initiation of translation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1436917874351086334","title":"Amino acid biosynthesis and central carbon metabolism","description":"The top GO terms cluster around core metabolic processes: TCA cycle, isocitrate metabolism, and NADPH regeneration, with multiple entries for L-leucine and L-lysine biosynthesis. Iron-sulfur cluster assembly supports essential metabolic enzymes, and antibiotic biosynthetic process suggests secondary metabolism that uses central metabolites as precursors. Some regulatory terms appear peripheral (phospholipid biosynthesis regulation; glial proliferation), but the dominant signal is biosynthesis and energy metabolism.","confidence":"Medium","size":7,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0016226","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0009098","count":2}]},{"hash":"1834634524486880601","title":"ER-associated protein quality control and trafficking","description":"This cluster is driven by GO terms related to ER-associated degradation (ERAD), retrograde transport to the cytosol, establishment of ER membrane localization, and general protein quality control, suggesting a cohesive theme around quality control and intracellular trafficking of proteins within the secretory pathway. A few outliers (lipoteichoic acid biosynthesis, immune regulation) are present but do not redefine the core function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":2},{"id":"GO:0030970","count":1},{"id":"GO:0036010","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0097051","count":1}]},{"hash":"1556318403852482496","title":"Neural development and synaptic signaling","description":"The cluster centers on nervous system/brain development and neural signaling, including Roundabout and Smoothened pathways and regulation of synaptic vesicle exocytosis, suggesting proteins involved in neuronal development and synaptic communication; a few terms like T cell receptor signaling appear as outliers.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0007286","count":3},{"id":"GO:0043087","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0010796","count":3}]},{"hash":"1105832910038026904","title":"Gene expression regulation and sensory organ development","description":"The cluster is dominated by GO terms for transcription (DNA-templated and its regulation) and RNA processing (mRNA splicing, modification) as well as translation initiation, indicating a core function in gene expression control. The presence of antennal and photoreceptor development terms suggests a potential link to sensory organ development in insects, though this is a secondary signal compared to the transcription/RNA processing theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0045316","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0002038","count":1}]},{"hash":"483025457593876523","title":"Mitotic control and DNA repair","description":"These proteins are dominated by signals of cell-cycle regulation and genome maintenance: SCF-dependent ubiquitin-proteasome\u2013mediated protein degradation, G2/M transition, mitotic exit, and chromosome segregation, along with DNA repair pathways (NER and postreplication repair). While some other terms (peroxisomal import, viral process, T cell receptor signaling) are broader or context-dependent, the core theme is coordination of mitosis with DNA damage response and repair mechanisms.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031146","count":7},{"id":"GO:0000086","count":7},{"id":"GO:0010458","count":7},{"id":"GO:0007059","count":7},{"id":"GO:0070911","count":7}]},{"hash":"2297659713416342434","title":"Ribosome Biogenesis and Translation","description":"The top GO terms cluster around ribosome production and activity: translation (GO:0006412), ribosomal large subunit biogenesis (GO:0042273), and LSU-rRNA maturation (GO:0000463), plus ribosomal large subunit assembly (GO:0000027). A few terms touch on protein quality control and targeting (protein stabilization; negative regulation of ubiquitin-related processes), suggesting regulation of ribosome-related proteins. Overall, the cluster reflects ribosome biogenesis and the translation machinery with some supporting regulatory processes.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042273","count":2},{"id":"GO:0000463","count":2},{"id":"GO:1901194","count":1},{"id":"GO:0000027","count":1}]},{"hash":"563266463400213696","title":"Small-molecule metabolism cluster","description":"Based on the top GO terms, the proteins are predominantly linked to metabolic processes involving small organic molecules (cholesterol, glycine betaine, methanol, methane, guanine), suggesting a broad metabolic cluster rather than a single specific pathway. A few non-metabolic annotations appear but are less representative of the core signal.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008203","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0019285","count":5},{"id":"GO:0015945","count":5},{"id":"GO:0046188","count":5}]},{"hash":"923200361062491091","title":"Unknown","description":"The terms span DNA replication, neural development, immune signaling, and stress responses, with no single unifying function evident among the proteins. The absence of edges and the scattered GO terms suggest the cluster is not functionally cohesive, so a precise label cannot be assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0020021","count":6},{"id":"GO:0060440","count":6},{"id":"GO:0021537","count":6},{"id":"GO:0050852","count":6}]},{"hash":"424738912302815430","title":"Vascular Signaling and Tissue Remodeling","description":"This cluster's GO terms center on angiotensin-activated signaling and regulation of blood pressure, along with cell adhesion and tissue regeneration, suggesting a theme of vascular signaling and extracellular matrix\u2013mediated tissue remodeling. A few lipid-related terms appear as outliers or cross-species annotations, but the dominant signal points to vascular development and tissue remodeling processes.","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0038166","count":1},{"id":"GO:0008217","count":1},{"id":"GO:0001954","count":1},{"id":"GO:0042246","count":1},{"id":"GO:1990384","count":1}]},{"hash":"1721506084221256625","title":"Nuclear RNA processing and ribosome export","description":"Top terms are dominated by rRNA maturation and RNA export from the nucleus, pointing to ribosome biogenesis and nucleocytoplasmic transport as the cluster's main function. Additional terms suggest broader nuclear/cell-cycle regulation, but the clearest shared theme remains ribosome-related RNA processing and export.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":1},{"id":"GO:0000469","count":1},{"id":"GO:0090526","count":1},{"id":"GO:0007051","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1729073290020568170","title":"DNA replication initiation and chromatin maintenance","description":"The cluster is dominated by GO terms related to DNA replication initiation (mitotic DNA replication initiation, regulation of DNA-templated DNA replication initiation) and assembly of the MCM complex, plus chromatin-related processes (heterochromatin formation, BIR repair). These collectively point to a module focused on genome duplication and chromatin regulation. The photosynthesis term appears as an outlier and does not define the main theme. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0015979","count":5},{"id":"GO:0007049","count":5},{"id":"GO:0030163","count":4},{"id":"GO:0030174","count":4},{"id":"GO:0006268","count":4}]},{"hash":"904006012907021310","title":"Coagulation and Fibrinolysis Regulation","description":"The cluster\u2019s top GO terms center on negative regulation of plasminogen activation and fibrinolysis, alongside blood coagulation and bradykinin catabolism, indicating a core theme of hemostasis and proteolytic control; additional terms on xenobiotic response, extracellular matrix secretion, and liver regeneration suggest contextual connections to tissue remodeling and repair.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051918","count":4},{"id":"GO:0010757","count":4},{"id":"GO:0006508","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0007596","count":3}]},{"hash":"539453926226839622","title":"Sulfur metabolism and redox homeostasis","description":"The set is dominated by GO terms related to redox balance and sulfur biology (cell redox homeostasis, transsulfuration, tRNA wobble uridine thiolation, and cysteine-related modifications such as urmylation), suggesting a functional theme around sulfur transfer and redox chemistry. A few terms concern development and differentiation (spinal cord development, epithelial cell differentiation) and cell cycle (mitotic M phase) that are less clearly connected, which may reflect annotation noise or multifunctional proteins. Overall, the cluster likely centers on sulfur metabolism linked to redox homeostasis.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":7},{"id":"GO:2000220","count":5},{"id":"GO:0021510","count":5},{"id":"GO:0032447","count":5},{"id":"GO:0002143","count":5}]},{"hash":"1666532019367570179","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0032543","count":1},{"id":"GO:0071031","count":1}]},{"hash":"77426985092661869","title":"Fungal sterol and sphingolipid metabolism","description":"This cluster shows strong representation of lipid-related processes: regulation of ergosterol biosynthesis (fungal sterol), mannosyl-inositol phosphorylceramide (a sphingolipid) metabolism, and unsaturated fatty acid biosynthesis/oxidation. These together point to lipid membrane biosynthesis and homeostasis in fungi, despite a few unrelated mammalian terms in the mix. ","confidence":"Medium","size":7,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032443","count":3},{"id":"GO:0001949","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0006636","count":3},{"id":"GO:0042128","count":3}]},{"hash":"2081525928944379408","title":"Neural signaling and differentiation","description":"This cluster is dominated by terms for intracellular signal transduction and cerebellar granule cell differentiation, suggesting signaling roles in neural development. Other terms point to broader signaling regulation (dephosphorylation, membrane depolarization) but neural-related terms appear to be the most representative. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0070213","count":2},{"id":"GO:1904908","count":2},{"id":"GO:0030103","count":2}]},{"hash":"2226838613882777755","title":"Nuclear RNA Processing and Spliceosome Assembly","description":"The cluster centers on RNA maturation and processing: mRNA splicing via spliceosome, tRNA processing, SSU-rRNA maturation, and spliceosomal complex assembly, with related roles in nuclear mRNA decapping and P-body assembly. Additional terms for nuclear import and chromatin-related silencing hint broader nuclear organization, but the dominant theme is RNA processing and quality control.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0008033","count":5},{"id":"GO:1990141","count":5},{"id":"GO:0030490","count":5},{"id":"GO:0051170","count":5}]},{"hash":"986054582547341730","title":"Nuclear RNA processing and splicing","description":"The terms cluster around RNA maturation and splicing: tRNA processing, SSU-rRNA maturation, spliceosome-mediated splicing, spliceosomal assembly, and associated nuclear import and P-body dynamics, pointing to a cohesive nuclear RNA processing program. Plant stress terms (ABA, water deprivation) hint at regulatory context but do not override the core RNA-centric function.","confidence":"Medium","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":3},{"id":"GO:1990141","count":3},{"id":"GO:0030490","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0051170","count":3}]},{"hash":"734205298906034327","title":"Adaptive immune and angiogenesis signaling","description":"Proteins in this cluster are enriched for adaptive immune response and angiogenesis-related GO terms, notably adaptive immune response (GO:0002250), angiogenesis (GO:0001525), and positive regulation of endothelial cell migration (GO:0043536), with ERK cascade regulation (GO:0070374) also highlighted. This points to a shared theme of immune-driven signaling that promotes vascular remodeling and coordinated cell signaling, even though some terms reflect broader cellular processes.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0043536","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0010519","count":2}]},{"hash":"1533920116691096413","title":"Ubiquitin-like Modifier Conjugation","description":"The top GO terms are dominated by protein modification via ubiquitin-like modifiers (sumoylation, neddylation, ufmylation, urmylation) and related lipidation, indicating a coherent focus on ubiquitin-like conjugation pathways. Other terms (tRNA modifications, molybdenum cofactor biosynthesis) are present but secondary, supporting the central theme of ubiquitin-like modification networks.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":4},{"id":"GO:0002143","count":3},{"id":"GO:0061504","count":3},{"id":"GO:0006501","count":3},{"id":"GO:0050832","count":3}]},{"hash":"667541150553331821","title":"Triglyceride and phospholipid catabolic remodeling","description":"The cluster is strongly characterized by lipid metabolism terms: triglyceride catabolic process, triglyceride mobilization, triglyceride acyl-chain remodeling, and phosphatidylcholine/phosphatidylethanolamine catabolic processes, indicating coordinated breakdown and remodeling of triglycerides and membrane lipids. The additional related term on negative regulation of PKA activity is secondary but does not alter the lipid-centric theme.","confidence":"High","size":6,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":3},{"id":"GO:0034638","count":2},{"id":"GO:0036153","count":2},{"id":"GO:0046338","count":2},{"id":"GO:0010898","count":2}]},{"hash":"639389823644473277","title":"Flavonoid and lignin biosynthesis","description":"The top GO terms point to flavonoid/anthocyanin production (anthocyanin-containing compound biosynthesis, cyanidin 3-O-glucoside and quercetin O-glucoside biosynthesis) and lignin metabolism, all part of the plant phenylpropanoid pathway. Some terms seem unrelated (e.g., antibiotic biosynthesis, lipoteichoic acid biosynthesis), likely annotation noise, but the dominant signal supports flavonoid and related phenylpropanoid biosynthesis. Confidence: High","confidence":"","size":6,"edges":9,"triangles":4,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":5},{"id":"GO:0017000","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0071412","count":3},{"id":"GO:0070395","count":3}]},{"hash":"1197223006134104143","title":"Proteostasis and stress response","description":"The cluster\u2019s GO terms point to core proteostasis mechanisms under stress: ER unfolded protein response, autophagosome maturation, chaperone-mediated assembly, and general protein processing, along with heat acclimation and stress granule dynamics, indicating a cohesive focus on maintaining protein quality and cellular homeostasis during stress; RNA processing and peroxisomal targeting terms may reflect broader stress-adaptive regulation of gene expression.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":2},{"id":"GO:0016558","count":1},{"id":"GO:0035617","count":1},{"id":"GO:0030420","count":1},{"id":"GO:0030968","count":1}]},{"hash":"147020565978074625","title":"Nuclear RNA Processing and Spliceosome Assembly","description":"The cluster is enriched for splicing-related terms (mRNA cis splicing via spliceosome, spliceosomal complex assembly), mRNA decay (deadenylation-dependent decapping), and RNA maturation (tRNA processing, maturation of SSU-rRNA), plus nuclear import and P-body assembly. This points to a cohesive theme of RNA metabolism and ribonucleoprotein complex assembly in the nucleus, particularly spliceosome function and RNA maturation processes.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0008033","count":3},{"id":"GO:1990141","count":3},{"id":"GO:0030490","count":3},{"id":"GO:0051170","count":3}]},{"hash":"441194478052754442","title":"Innate immune signaling and chemokine production","description":"The top GO terms point to immune-related functions, notably Fc-epsilon receptor signaling, innate immune response, and positive regulation of chemokine production, suggesting the proteins share a common role in immune signaling and chemokine-mediated communication. Other terms (heart development, potassium channel clustering) are less central and may reflect broader, pleiotropic annotations, but do not outweigh the immune-focused pattern.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":3},{"id":"GO:0045163","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1534935056429381738","title":"Central Carbon Metabolism and Lipid Synthesis","description":"These terms cluster around core carbon metabolism: glycolysis and pyruvate-to-acetyl-CoA fueling the TCA cycle and gluconeogenesis, with associated 2-oxoglutarate and leucine catabolism, and linked lipid biosynthesis via malonyl-CoA and fatty acid synthesis. This converges on central energy production and carbon flux into lipids, justifying the name Central Carbon Metabolism and Lipid Synthesis.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":2},{"id":"GO:0006086","count":2},{"id":"GO:0006552","count":1},{"id":"GO:0006094","count":1},{"id":"GO:0033512","count":1}]},{"hash":"1531161644093248742","title":"Cerebellar cortex development and gene expression","description":"The cluster shows enrichment for neural development terms, especially cerebellar cortex development and broader brain development, alongside DNA-templated transcription and translation initiation-related terms. This suggests a group of proteins involved in neural development with coordinated gene expression (transcription and translation) processes, even though some polyadenylation/RNA processing terms are outdated. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006363","count":1},{"id":"GO:0006388","count":1}]},{"hash":"582840428410713452","title":"Cytokine Signaling and NF-kappaB Inflammation","description":"This cluster predominantly features GO terms tied to cytokine signaling and NF-kappaB pathway activity (interleukin-8 production, responses to IL-6 and IL-1, NF-kappaB activation, apoptosis), suggesting a cohesive theme of inflammatory signaling. A few terms related to chitin/cuticle development appear, which may reflect broader or species-specific annotations, but the cytokine/NF-kappaB-related terms provide the core connection.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072606","count":1},{"id":"GO:0030324","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0006915","count":1}]},{"hash":"2284763926919148686","title":"Cardiovascular and renal development with cell adhesion","description":"This cluster is driven by terms tied to heart development (endocardial development, cardiac neural crest cell development in outflow tract morphogenesis) and kidney development (glomerular basement membrane and mesangial cell development), along with adhesion/ECM-related processes. The mix suggests a shared theme of organ development\u2014particularly heart and kidney\u2014with cell adhesion involvement.","confidence":"Medium","size":6,"edges":10,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":5},{"id":"GO:0045880","count":4},{"id":"GO:0044332","count":4},{"id":"GO:0032836","count":4},{"id":"GO:0007157","count":4}]},{"hash":"419392045278683544","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":1},{"id":"GO:0043535","count":1},{"id":"GO:0071519","count":1},{"id":"GO:0070060","count":1},{"id":"GO:0090140","count":1}]},{"hash":"458358874466785338","title":"Embryonic axis formation and development","description":"This cluster is best captured by GO terms emphasizing embryogenesis and body axis patterning, notably maternal specification of the dorsal/ventral axis and left-right pattern formation, along with related developmental processes like endocrine system and placental differentiation. Although some terms point to general cellular processes (RNA splicing, ribosomal export), the recurring theme centers on embryonic development and axis specification.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0060806","count":6},{"id":"GO:1903026","count":6}]},{"hash":"1248807308519833226","title":"Metabolic and Nutrient Stress Response","description":"The cluster is dominated by metabolic processes (retinol and ethanol catabolism, GABA shunt, 4-hydroxyphenylacetate catabolism, glycine betaine biosynthesis) and responses to nutrients and decreased oxygen, pointing to a metabolic core with nutrient/oxygen stress signaling. A few terms (olfactory pit development, endothelial proliferation) are less central but may reflect broader developmental or vascular contexts linked to metabolism.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":6},{"id":"GO:0006068","count":6},{"id":"GO:0007584","count":6},{"id":"GO:0006540","count":6},{"id":"GO:0001936","count":6}]},{"hash":"1340301411221326684","title":"Flavonoid and lignin biosynthesis","description":"These terms point to the biosynthesis of plant secondary metabolites, especially flavonoids (cyanidin- or quercetin-related processes, anthocyanin-containing compounds) and lignin. While there are a couple of seemingly unrelated terms (lipoteichoic acid biosynthesis, paranode localization) that may reflect noise or misannotations, the dominant signals align with phenylpropanoid-derived metabolite synthesis. Confidence: Medium.","confidence":"","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070395","count":5},{"id":"GO:0002175","count":5},{"id":"GO:0071412","count":4},{"id":"GO:0033485","count":4},{"id":"GO:0009718","count":4}]},{"hash":"117604449828655991","title":"Innate Immune Signaling and Defense","description":"The top GO terms cluster around host defense and immune signaling, including NOD-like receptor signaling, defense response to Gram-positive bacteria, and regulation of NF-kappaB activity, with additional involvement in MHC class I biosynthesis. Although a few terms are unrelated (e.g., Wnt signaling, floral meristem regulation and mechanical stimulus response), the core signals point to innate immune pathways and antigen processing, justifying an immune-focused label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0014068","count":2}]},{"hash":"278481442394557972","title":"T cell activation and immune cell trafficking","description":"The cluster is enriched with adaptive immune signaling and leukocyte migration terms: T cell receptor signaling, IL-6-mediated signaling, IL-7\u2013mediated responses, diapedesis, and angioblast migration, plus store-operated calcium channel activation linked to T cell activation. Taken together, these proteins likely participate in T cell\u2013driven immune activation and immune cell trafficking.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":6},{"id":"GO:0070102","count":5},{"id":"GO:0098761","count":5},{"id":"GO:0032237","count":5},{"id":"GO:0050904","count":5}]},{"hash":"600605596752693692","title":"Chemosensory perception and behavior","description":"The proteins in this cluster are linked to chemosensory cues and related behaviors, including taste, odor/CO2 detection, insecticide/toxin responses, pheromone-based courtship cues, and even light-driven movement, indicating a common theme of chemical cue detection and behavioral response.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":1},{"id":"GO:0031000","count":1},{"id":"GO:0003031","count":1},{"id":"GO:0010037","count":1},{"id":"GO:0007635","count":1}]},{"hash":"608131597804991644","title":"Neuronal mitochondrial import and ROS regulation","description":"The terms cluster around mitochondrial functions (protein import into mitochondrial matrix, calcium import into mitochondrion, regulation of autophagy of mitochondrion, and negative regulation of ROS metabolism) with neural activity indicators (neuron-neuron synaptic transmission, learning, fear response). This suggests proteins acting in neurons to maintain mitochondrial quality control and redox balance, which can influence neural signaling and plasticity. Some terms like cilium assembly or epithelial differentiation are less central but may reflect broader cellular roles or annotations. Overall, the core theme is neuronal mitochondrial function and ROS regulation.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007612","count":2},{"id":"GO:1902017","count":2},{"id":"GO:0036444","count":2},{"id":"GO:0006820","count":2},{"id":"GO:0030855","count":2}]},{"hash":"1596468882253708396","title":"GPCR-driven cAMP/cGMP Signaling and Transcription","description":"Top GO terms point to GPCR-activated signaling that elevates cAMP and/or cGMP (adenylate cyclase\u2013activating pathways) and broader intracellular signal transduction, coupled with regulation of transcription. This pattern suggests a GPCR-mediated second-messenger signaling module linking external cues to gene expression and stress-related responses.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032026","count":2},{"id":"GO:0071880","count":2},{"id":"GO:0052565","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0006171","count":2}]},{"hash":"1721284344379912907","title":"Embryonic Neural Development","description":"The top GO terms point to neural development (neural tube closure, forebrain development) and broader embryonic/multicellular development (skeletal system development, multicellular organism development). While there are also transcription and stress/immune terms, the dominant signal is developmental programming in embryonic/neuronal contexts. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001843","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0050830","count":3}]},{"hash":"1464058456330481160","title":"Unknown","description":"The top terms span diverse tissues and development contexts (plants, pancreatic/D cell, Purkinje and midbrain neurons, reproductive tract), plus general processes like RNA polymerase II transcription and actin organization. This lack of a single cohesive function or pathway makes it unclear how these proteins relate functionally, so Unknown is most appropriate.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010088","count":4},{"id":"GO:0042789","count":4},{"id":"GO:0050859","count":4},{"id":"GO:0003324","count":4},{"id":"GO:0097067","count":4}]},{"hash":"2015950099933027562","title":"Mitotic spindle assembly and cell cycle control","description":"This cluster is dominated by GO terms tied to mitosis and spindle dynamics (mitotic spindle assembly, mitotic cell cycle, establishment of mitotic spindle orientation, regulation of meiotic nuclear division) along with related cytoskeletal and chromatin processes (actin filament depolymerization, histone H3 acetylation, protein monoubiquitination). While there are developmental terms like gastrulation and neural tube closure, the strongest signal centers on mitotic machinery and cell cycle regulation, suggesting proteins in this cluster coordinate mitosis with some broader regulatory roles.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0030042","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0007369","count":3}]},{"hash":"1906544127426349572","title":"Actin cytoskeleton, polarity, and cytokinesis","description":"The cluster shows a clear pattern around actin dynamics (actin cortical patches, contractile ring) and processes that shape and divide cells (polarity, cell shape regulation, cytokinesis, and related growth/inheritance). While a few terms (retina homeostasis, inter-male aggression, skeletal muscle development) are unrelated noise, the dominant signal centers on actin-driven cytoskeleton organization and cell division.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001895","count":5},{"id":"GO:0002121","count":5},{"id":"GO:0071963","count":5},{"id":"GO:0043486","count":5},{"id":"GO:0048741","count":5}]},{"hash":"308751004467017584","title":"Cholesterol and lipid energy metabolism","description":"The top terms cluster around cholesterol metabolism, transport, and fatty acid oxidation, including acetyl-CoA catabolic and ketone body biosynthetic processes; brain and liver development terms reflect tissue contexts tied to lipid metabolism and energy production, supporting a cohesive lipid/metabolic theme. ","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008203","count":4},{"id":"GO:0030435","count":4},{"id":"GO:0032385","count":4},{"id":"GO:0009725","count":4},{"id":"GO:0001889","count":4}]},{"hash":"1682398947940398122","title":"Actin Cytoskeleton and Cell Polarity","description":"The top GO terms cluster around actin-based processes: actin cortical patch assembly, actomyosin contractile ring contraction, cell polarity establishment/maintenance, and related growth and cytoskeletal dynamics, suggesting a set of proteins involved in cytoskeletal organization and cell shape regulation. A few terms (retina homeostasis, skeletal muscle fiber development, inter-male aggressive behavior) seem broader or less directly connected, indicating some multifunctionality or species-specific roles. Overall, the dominant theme points to actin cytoskeleton dynamics and polarity control.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001895","count":4},{"id":"GO:0002121","count":4},{"id":"GO:0071963","count":4},{"id":"GO:0043486","count":4},{"id":"GO:0048741","count":4}]},{"hash":"230844566926768323","title":"DNA replication and repair","description":"This cluster is dominated by GO terms tied to DNA replication, repair, and polymerase activity (DNA replication, leading strand elongation, UV-damage excision repair, error-free translesion synthesis, and positive regulation of DNA polymerase activity) along with cell division, suggesting a core theme of genome maintenance. A few terms (peroxisome protein import, stress granule disassembly, transformation competence) are less directly related, but the central pattern points to replication and repair processes. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0016558","count":3},{"id":"GO:0070987","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0070914","count":3},{"id":"GO:1900264","count":3}]},{"hash":"1999226530202179463","title":"Unknown","description":"The Top Terms are highly diverse, including coagulation, cell adhesion, angiogenesis-related processes, hypoxia response, and even memory, with an obsolete term among them. There is no strong shared theme or enrichment pointing to a single coherent function for all proteins, suggesting the cluster does not reflect a specific, interpretable biological process. Therefore, the label Unknown with None confidence is most appropriate.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0007596","count":1},{"id":"GO:0042691","count":1},{"id":"GO:0007161","count":1},{"id":"GO:0019371","count":1}]},{"hash":"434063271869003251","title":"Immune receptor signaling and proteasome-mediated degradation","description":"Dominant terms point to immune receptor signaling pathways (T cell receptor, Fc receptor, and C-type lectin receptor signaling). The co-occurrence of SCF-dependent ubiquitin-proteasome catabolic process suggests a link to protein turnover that modulates signaling, with peripheral hints of viral response and peroxisomal import. Overall, the cluster centers on immune signaling interconnected with ubiquitin-proteasome\u2013mediated degradation.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0031145","count":5},{"id":"GO:0002223","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0038095","count":5}]},{"hash":"1151560082982067790","title":"Innate immune signaling and cytokine production","description":"The GO terms point to innate immunity, including innate immune response, Toll-like receptor 2 signaling, dendritic cell cytokine production, and chemokine production, as well as MHC class I biosynthesis, suggesting a cluster of proteins involved in initiating and regulating immune signaling and antigen presentation. Some terms (DNA integration, floral meristem regulation) seem unrelated or noisy in this small set, but the dominant theme centers on immune activation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0010080","count":1},{"id":"GO:0045345","count":1},{"id":"GO:0032760","count":1},{"id":"GO:1903125","count":1}]},{"hash":"1303091979215703652","title":"Spliceosome and Ribosome Regulation","description":"The top terms cluster around RNA processing and protein synthesis: spliceosome-related activities (tri-snRNP assembly and conformational changes) alongside multiple stages of translation (initiation, termination, elongation, and ribosome disassembly). A couple of neural-related terms appear but are likely context-specific rather than central to the core function. Overall, the cluster seems to reflect coordinated RNA processing and translation control.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0006415","count":3},{"id":"GO:0000388","count":3},{"id":"GO:0045901","count":3},{"id":"GO:0032790","count":3}]},{"hash":"1305103315001237873","title":"Embryonic development and tissue morphogenesis","description":"The protein set is linked to multiple developmental processes across several organs (forebrain patterning, brain segmentation, cerebellum development, heart tube patterning, dentin/tooth formation, ear morphogenesis, skeletal muscle differentiation, etc.). This points to a broad developmental program and tissue morphogenesis rather than a single function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021798","count":4},{"id":"GO:0098528","count":4},{"id":"GO:0021902","count":4},{"id":"GO:0042474","count":4},{"id":"GO:0035284","count":4}]},{"hash":"536252577299188644","title":"RNA processing and ribosome biogenesis","description":"The top GO terms cluster around splicing via the spliceosome and maturation/biogenesis of rRNA and ribosomal subunits, suggesting a coherent function in RNA processing and ribosome assembly; a few development-related terms appear but do not override the core RNA-processing theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0000463","count":3}]},{"hash":"145917762124955632","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035640","count":1},{"id":"GO:1904574","count":1},{"id":"GO:0072715","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0006363","count":1}]},{"hash":"46600290100496307","title":"Solute Transmembrane Transporters","description":"The cluster\u2019s GO terms revolve around transmembrane transport of diverse solutes (nitrate, sugars like galactose and arabinose, sodium ions, sialic acid, fucose, and related compounds), plus a vesicular transport function (neurotransmitter loading). This suggests a coherent theme of membrane-transport proteins handling various substrates across membranes, rather than a single substrate-specific function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0035725","count":3}]},{"hash":"656439614990077957","title":"Unknown","description":"Top GO terms span neuronal apoptosis regulation, hippocampus and compound eye development, a Cvt pathway autophagy step, erythrocyte differentiation, embryonic development in Drosophila, responses to antibiotics and xenobiotics, T cell homeostasis, and regulation of cyclin-dependent kinase activity. This broad mix across tissues and processes shows no cohesive shared function, making the cluster functionally heterogeneous and not readily labelable.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043525","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0032258","count":2},{"id":"GO:0030218","count":2},{"id":"GO:0048749","count":2}]},{"hash":"839215619647566056","title":"Translation Initiation and Proteasome Regulation","description":"The cluster centers on GO terms related to translation initiation, preinitiation complex formation, and proteasome assembly/ubiquitin-dependent protein degradation. This points to a theme of coordinated protein synthesis and turnover, with a few developmental/differentiation terms present likely reflecting broader roles in cell fate processes. Overall, translation control and proteostasis appear to bind these proteins together.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0043248","count":1},{"id":"GO:0008283","count":1},{"id":"GO:0034260","count":1}]},{"hash":"525466342765654180","title":"Developmental Epigenetic Regulation","description":"These proteins are linked to histone modification and DNA methylation regulation, indicating epigenetic control, with supporting developmental contexts such as placental morphogenesis, spermatid differentiation, and lung development. Some terms are obsolete or endocrine-related, but the core signal points to epigenetic regulation during development.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043972","count":1},{"id":"GO:2000864","count":1},{"id":"GO:0060669","count":1},{"id":"GO:0044030","count":1},{"id":"GO:2000791","count":1}]},{"hash":"1937078315178958911","title":"Flavonoid and lignin biosynthesis","description":"The top GO terms cluster around biosynthesis of flavonoids (anthocyanin, kaempferol, quercetin, cyanidin, and related glucosides) and lignin, pointing to a shared theme of phenylpropanoid-derived secondary metabolite production. Some terms (like lipoteichoic acid biosynthesis and a cell division term) appear as noise, but the dominant signal is flavonoid biosynthesis and related lignin metabolism, suggesting a cohesive functional theme for this protein group.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0071412","count":3},{"id":"GO:0070395","count":3},{"id":"GO:0033485","count":3},{"id":"GO:0009718","count":3},{"id":"GO:0009808","count":3}]},{"hash":"2276261143145249644","title":"Lipid biosynthesis and fatty acid elongation","description":"The cluster is dominated by GO terms tied to lipid metabolism, especially fatty acid elongation, methyl-branched and very long-chain fatty acid biosynthesis, and sphinganine metabolism, pointing to a core role in lipid biosynthesis. Some terms like retinol and estrogen biosynthesis also align with lipid-derived metabolite pathways, though they may reflect organism-specific contexts or broader lipid-related processes. Overall, lipid biosynthesis is the most coherent theme across the terms.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042572","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0030435","count":3},{"id":"GO:0030497","count":3},{"id":"GO:0042438","count":3}]},{"hash":"2256011078565180615","title":"Unknown","description":"GO terms cover circadian regulation of translation and gene expression, developmental processes (mammary alveolus development, neural fold elevation), signaling, metabolism, immune/homeostasis, and wound healing. With no edges and no clear cohesive function, there is no single theme tying the proteins together, so Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097167","count":3},{"id":"GO:0061030","count":3},{"id":"GO:0021502","count":3},{"id":"GO:0032922","count":3},{"id":"GO:1903715","count":3}]},{"hash":"177785484803237521","title":"Vascular coagulation and endothelial barrier regulation","description":"These proteins co-occur with GO terms centered on blood coagulation, negative regulation of endothelial barrier establishment, and prostaglandin-driven inflammatory signaling, plus related circadian regulation and smooth muscle effects. The cluster thus points to a vascular inflammation/coagulation regulatory module rather than a single enzymatic function. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":3},{"id":"GO:0007596","count":3},{"id":"GO:1903141","count":3},{"id":"GO:0042752","count":3},{"id":"GO:0071799","count":3}]},{"hash":"2268382290406089661","title":"Neural Vision and Drug-Response Signaling","description":"This cluster centers on nervous-system\u2013related sensory processing and drug-induced behavioral responses. Visual perception and visual learning terms point to neural vision processing, while morphine and cocaine response terms indicate drug-related behaviors. Additional terms suggest brain signaling and cross-talk with immune pathways (dsRNA response, macrophage chemotaxis) and GTPase regulation, aligning with broader neural signaling involved in sensory input processing and behavior.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0043330","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1755418506489254201","title":"Developmental signaling and proteolysis","description":"The top GO terms cluster around developmental and signaling processes (positive regulation of peptidyl-tyrosine phosphorylation, multicellular organism growth, single fertilization, gastrulation, TGF-beta receptor signaling) and protein turnover (SCF-dependent proteasomal ubiquitin-dependent degradation, ubiquitin-dependent ERAD). There is some evidence for lysosomal involvement (phagolysosome assembly) and broader gene expression processes (mRNA splicing), but the strongest signal points to signaling controlling development in conjunction with proteostasis. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050731","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0001845","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0007338","count":2}]},{"hash":"739145825651666375","title":"Chemosensory Pheromone Signaling and Fertilization","description":"The top GO terms cluster around chemosensory communication and reproductive processes: sensory perception of smell, social behavior, and response to pheromone point to pheromone-mediated signaling, while fertilization and sperm-egg fusion highlight reproductive interactions. Transport and occasional retina or defense terms appear less prominently, suggesting some multifunctionality or incidental associations, but the dominant theme ties pheromone sensing to mating-related events.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0007608","count":2},{"id":"GO:0019236","count":2},{"id":"GO:0001895","count":1}]},{"hash":"1949688528572652574","title":"Neural and muscular development","description":"The top GO terms indicate development of neural tissues (brain, forebrain, myelin maintenance, visual learning) and musculature (skeletal muscle development/differentiation, heart development, craniofacial structures like roof of mouth). Although one term (B cell receptor signaling) is an outlier, the dominant theme across the cluster is developmental processes spanning neural, muscular, and related organ morphogenesis, suggesting a broad neuro-musculoskeletal developmental program.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0048853","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1206055496772383114","title":"Nicotine-Related Neurotransmission Signaling","description":"The top GO terms center on neural signaling and nicotine-related responses, including behavioral and cellular responses to nicotine, serotonin and GABA receptor signaling, and glycinergic synaptic transmission, plus regulation of nerve impulse transmission and circadian sleep modulation. This suggests a cohesive cluster of genes involved in nervous system signaling with a focus on nicotine responsiveness, despite one seemingly unrelated term likely representing noise. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035095","count":1},{"id":"GO:0060012","count":1},{"id":"GO:0071294","count":1},{"id":"GO:0045188","count":1},{"id":"GO:0003428","count":1}]},{"hash":"1263015443110491289","title":"Flavonoid and lignin biosynthesis","description":"Most top GO terms describe biosynthetic steps for plant secondary metabolites\u2014anthocyanin-containing compounds, cyanidin and quercetin glycosides\u2014and lignin, plus related flavonoid glycosylation. This points to enzymes or components of the phenylpropanoid pathway. A few terms (paranode axon localization, estrogen catabolic process, antibiotic biosynthesis) appear unrelated or broad and may reflect annotation noise, but the dominant signal supports a role in flavonoid/lignin biosynthesis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0071412","count":3},{"id":"GO:0033485","count":3},{"id":"GO:0002175","count":3},{"id":"GO:0033303","count":3}]},{"hash":"1673174524769680509","title":"Cell adhesion and signaling in development and immunity","description":"The top GO terms point to a shared theme of cell signaling and adhesion processes that play roles across development (myoblast fusion, angiogenesis regulation, morphogenesis, nephrocyte filtration) and immune function (T cell signaling, T cell selection, B-1 B cell differentiation). There is a clear emphasis on cytoskeletal dynamics and cell-matrix interactions (Rho signaling regulation and calcium-independent adhesion) that underpin cell communication and adhesion in multiple contexts. While the cluster includes diverse processes, the common thread appears to be proteins involved in signaling and adhesion shaping development and immune cell behavior.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007520","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0045058","count":3},{"id":"GO:0045765","count":3},{"id":"GO:0001923","count":3}]},{"hash":"972292156249989721","title":"COPI-mediated ER-Golgi transport","description":"The top GO terms are dominated by ER-to-Golgi vesicle transport, COPI coating and vesicle budding, and Golgi ribbon formation, all pointing to COPI-dependent trafficking between the endoplasmic reticulum and Golgi. A few other terms appear but seem peripheral to the main function. Overall, the cluster centers on intracellular vesicle trafficking rather than signaling or development.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0043695","count":1},{"id":"GO:0001893","count":1},{"id":"GO:0070863","count":1},{"id":"GO:0002121","count":1}]},{"hash":"805200856502148407","title":"Inflammatory Signaling and Chemokine Production","description":"The cluster prominently features GO terms tied to immune function, especially inflammatory response and regulation of chemokine production, suggesting a group of proteins involved in immune signaling. The chitin catabolic and general carbohydrate metabolism terms are less connected but present, likely reflecting broader metabolic context or annotation noise; overall, the immune/inflammatory theme best explains the cluster. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":4},{"id":"GO:0090197","count":4},{"id":"GO:0002532","count":4},{"id":"GO:0005975","count":4},{"id":"GO:0048294","count":1}]},{"hash":"2260860085019941444","title":"Nucleotide and Cofactor Biosynthesis","description":"The proteins are enriched for GO terms tied to biosynthesis of cofactors such as CoA and NAD+, and nucleotide metabolism including phosphorylation, salvage, and interconversion. This collection points to a shared role in producing and processing nucleotide cofactors and related metabolites, giving a cohesive metabolic theme despite no detected protein\u2013protein edges in this cluster. The development terms appear incidental to the main metabolic signal.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":3},{"id":"GO:0046940","count":2},{"id":"GO:0046939","count":2},{"id":"GO:0009435","count":2},{"id":"GO:0016310","count":2}]},{"hash":"2132392027961309744","title":"Membrane Transport of Small Metabolites","description":"The top GO terms are dominated by transport across the plasma membrane for a variety of substrates (sodium ions, sugars, vitamins, and related biosynthetic processes), indicating a cohesive theme of membrane transporter activity handling diverse small molecules. A few outlier terms (social behavior, smell) may reflect annotation noise rather than a core function of this cluster.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071436","count":4},{"id":"GO:0015798","count":4},{"id":"GO:0015887","count":4},{"id":"GO:0008292","count":4},{"id":"GO:1904659","count":4}]},{"hash":"1229113648861460988","title":"Meiotic DNA repair and chromosome maintenance","description":"The top GO terms center on meiotic double-strand break repair, telomere maintenance via recombination, and synaptonemal complex assembly, plus interstrand cross-link repair, indicating proteins involved in meiosis-specific DNA repair and chromosome maintenance. Some peripheral terms exist but do not override this core theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990918","count":2},{"id":"GO:0000722","count":2},{"id":"GO:0036297","count":1},{"id":"GO:2000269","count":1},{"id":"GO:0006268","count":1}]},{"hash":"452841766400244619","title":"Proteasome Regulation and Vesicle Trafficking","description":"Dominant terms focus on proteasomal ubiquitin-dependent protein catabolic processes, with both positive and negative regulation highlighted, plus intralumenal vesicle formation regulation, indicating a proteostasis and vesicular trafficking theme. Some outliers (spindle pole body duplication, axonogenesis) suggest broader cell-cycle/development roles, but the proteasome/trafficking connection best represents the cluster.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1905366","count":4},{"id":"GO:1902260","count":4},{"id":"GO:0032436","count":4},{"id":"GO:0030474","count":4},{"id":"GO:0048936","count":4}]},{"hash":"888121369699425706","title":"Telomere maintenance via telomerase regulation","description":"The cluster\u2019s strongest signals are around positive regulation of telomerase activity and telomere maintenance via telomerase, which ties to cell division. Additional terms point to proteostasis (protein stabilization, chaperone-mediated complex assembly) that supports proper telomerase and cell-cycle protein function. Some unrelated terms (inflammatory response, host cell translocation, cocaine response) may reflect noise or broader context, but the telomere/telomerase theme is the core. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051973","count":3},{"id":"GO:0050729","count":3},{"id":"GO:0051086","count":3},{"id":"GO:0050821","count":3},{"id":"GO:0032212","count":3}]},{"hash":"1604114303072918929","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0070934","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0009561","count":2},{"id":"GO:1904574","count":1}]},{"hash":"1752652104415486471","title":"Microtubule dynamics and spindle polarity","description":"The cluster centers on microtubule cytoskeleton organization, including establishment/maintenance of polarity, plus-end directed activities, spindle elongation and orientation, and chromosome alignment during mitosis/meiosis. While a few terms touch on related cytoskeletal roles (e.g., stress granule disassembly, chloroplast movement), the dominant theme is microtubule-driven spindle dynamics and polarity.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030951","count":3},{"id":"GO:0000022","count":3},{"id":"GO:0035617","count":3},{"id":"GO:0031535","count":3},{"id":"GO:0000742","count":3}]},{"hash":"1305010711393831363","title":"Unknown","description":"The GO terms cover several unrelated processes (calcium signaling, transcription/translation regulation, RNA processing, DNA damage checkpoints, and metabolism), with some obsolete entries, and no single cohesive function ties the proteins together.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060316","count":4},{"id":"GO:0007114","count":4},{"id":"GO:0036496","count":4},{"id":"GO:1903799","count":4},{"id":"GO:0070940","count":4}]},{"hash":"1922297759260081030","title":"Nuclear Transport and Mitotic Localization","description":"This cluster centers on nuclear trafficking: export of mRNA and ribosomal subunits, import of proteins into the nucleus, and kinetochore localization, all consistent with nuclear transport and cell division machinery. A few terms about xenobiotic response and protein catabolic regulation may be ancillary.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0000056","count":3}]},{"hash":"1891282922153998017","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019700","count":2},{"id":"GO:0042866","count":2},{"id":"GO:0019805","count":2},{"id":"GO:0019442","count":2},{"id":"GO:0034354","count":2}]},{"hash":"1501076185217579793","title":"Diverse Metabolite Biosynthesis","description":"The GO terms cluster around biosynthesis of various metabolites (nucleotides like UTP/GTP/dGTP, biotin, protoporphyrinogen IX/heme, and oxaloacetate-related metabolism) with some stress-response and signaling hints (hypoxia, cAMP, and histidine phosphorylation), suggesting a general metabolic biosynthesis module rather than a single pathway.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006107","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0051591","count":2}]},{"hash":"2279057433938355627","title":"Multi-tissue developmental morphogenesis","description":"This cluster groups GO terms across a range of developmental and morphogenetic processes in different tissues (phloem development in plants; brain patterning, cerebellum development, odontogenesis, middle ear morphogenesis, etc.), indicating a broad theme of development and tissue morphogenesis rather than a single specific function.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010088","count":2},{"id":"GO:0098528","count":2},{"id":"GO:0042789","count":2},{"id":"GO:0021798","count":2},{"id":"GO:0021902","count":2}]},{"hash":"1391727012728718463","title":"Transmembrane Transporters","description":"The top GO terms are dominated by various transmembrane transport activities (L-aspartate, fructose, oxalate, sulfate transport) and related membrane processes (regulation of membrane potential, intracellular pH elevation), indicating a cluster enriched for membrane transporter proteins. Other terms such as sporulation, transcription regulation, gastric acid secretion, and sensory perception of sound are less coherent with this theme, so the core label reflects the strongest shared function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042391","count":4},{"id":"GO:0089712","count":4},{"id":"GO:0015755","count":4},{"id":"GO:0030435","count":4},{"id":"GO:0019532","count":4}]},{"hash":"818613357850040695","title":"Post-transcriptional RNA processing and translation regulation","description":"The proteins in this cluster are enriched for processes controlling RNA after transcription\u2014splicing (including alternative splicing), mRNA modification and stability, and regulation of translation initiation and preinitiation complex formation\u2014pointing to a cohesive role in post-transcriptional gene expression regulation.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":4},{"id":"GO:0048026","count":3},{"id":"GO:0016556","count":3},{"id":"GO:1902625","count":3},{"id":"GO:1901407","count":3}]},{"hash":"1742359829584263161","title":"Developmental Signaling and Morphogenesis","description":"While the four proteins carry GO annotations spanning both plant and animal development, the common thread is developmental processes coordinated by signaling pathways. Terms cover structural and tissue development (larval cuticle, leaf), pattern specification, dendrite development/morphogenesis, and signaling pathways (ephrin receptor, prolactin). This suggests a broad role in development and morphogenesis rather than a single tissue-specific function, hence a general label like Developmental Signaling and Morphogenesis.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:1902213","count":1},{"id":"GO:0048013","count":1},{"id":"GO:0016358","count":1},{"id":"GO:1900170","count":1}]},{"hash":"859736612417844681","title":"Developmental differentiation and morphogenesis","description":"The GO terms point mainly to embryonic development and tissue patterning\u2014trophoblast differentiation, placenta-related processes, cartilage morphogenesis, and left-right pattern formation\u2014suggesting the cluster centers on developmental differentiation and morphogenesis. While some terms describe general cellular functions (mitochondrial calcium homeostasis, RNA splicing), the developmental terms are the most characteristic. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051560","count":1},{"id":"GO:0036444","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0060707","count":1}]},{"hash":"1838550452354291745","title":"Immune activation and antigen presentation with ER stress","description":"The top terms point to antigen processing and presentation (MHC I assembly), dendritic cell chemotaxis, and phagocytosis, indicating immune activation roles. Concurrent ER stress/quality-control terms (protein folding, unfolded protein response) and NF-kappaB signaling suggest a coordinated link between protein homeostasis and immune signaling. Vesicle endocytosis aligns with antigen uptake/trafficking. Overall, the cluster seems centered on immune function with ER stress involvement.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":2},{"id":"GO:2000510","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0048488","count":2},{"id":"GO:0050766","count":2}]},{"hash":"221361845418029425","title":"Unknown","description":"The terms span both developmental processes (embryonic development, neuron maturation) and broad cellular responses (xenobiotic response, redox homeostasis, apoptosis, membrane potential regulation, cAMP signaling). There is no single cohesive function linking all terms, so a precise, representative label cannot be assigned.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0044179","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0071320","count":2}]},{"hash":"805074191290871056","title":"Larval chitin-based cuticle development","description":"The cluster is dominated by a single GO term related to larval chitin-based cuticle development, suggesting the proteins participate in larval cuticle formation or remodeling. With only one supporting term and no interactions among members, the assignment is tentative and best described as a narrow cuticle-related function.","confidence":"Low","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"1739251835925177549","title":"Regulators of signaling and glycogen metabolism","description":"These proteins appear linked by regulatory roles: regulation of signal transduction, negative regulation of catalytic activity, and a glycogen metabolic process term. Even though there are no observed edges, the common theme is proteins that modulate signaling pathways and metabolic enzyme activity, particularly glycogen metabolism. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009966","count":1},{"id":"GO:0005977","count":1},{"id":"GO:0043086","count":1},{"id":"GO:0043666","count":1}]},{"hash":"406944216299756996","title":"Vesicle trafficking and endocytosis","description":"The strongest terms point to intracellular vesicle transport (Golgi-to-ER retrograde, endosome-to-melanosome) and endocytosis, with related hints from filopodium assembly and microtubule-based organelle movement. While signaling terms (GPCR, TCR) appear, they are less central to this cluster\u2019s core function, making vesicle trafficking and endocytosis the most representative theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0035646","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0071851","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1125968038051047064","title":"Unknown","description":"The GO terms are highly diverse, spanning sperm exocytosis, vascular development, hormone responses, cuticle attachment, sensory organ processes, TGF-beta signaling, and immune regulation, with no clear shared function or theme tying the proteins together. Therefore a precise, cohesive label isn\u2019t evident beyond Unknown. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060478","count":1},{"id":"GO:0022009","count":1},{"id":"GO:0040005","count":1},{"id":"GO:0034699","count":1},{"id":"GO:0032354","count":1}]},{"hash":"1799851175305609741","title":"Immune Activation and Cytokine Production","description":"The GO terms cluster around innate immune responses, macrophage activation, phagocytic respiratory burst, and regulation of cytokines/chemokines (TNF, MCP-1, T cell migration), suggesting a coordinated immune signaling module, despite a few outlier developmental terms.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007350","count":1},{"id":"GO:0050848","count":1},{"id":"GO:0002230","count":1},{"id":"GO:0010742","count":1},{"id":"GO:0018345","count":1}]},{"hash":"1338414622527449692","title":"Ribosome Biogenesis and Translation","description":"The cluster shows GO terms focused on ribosome maturation (5.8S rRNA, LSU/SSU rRNA), ribosomal subunit export, and translation, pointing to a shared function in ribosome assembly and protein synthesis. Some immune differentiation terms appear in the list, but they are less clearly linked to ribosome biology, suggesting possible annotation noise or broader roles. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903955","count":2},{"id":"GO:0071425","count":1},{"id":"GO:0030851","count":1},{"id":"GO:0033077","count":1},{"id":"GO:0046638","count":1}]},{"hash":"655339652545677292","title":"Unknown","description":"The GO terms listed cover membrane potential regulation, multiple metabolic processes (TCA cycle, 2-oxoglutarate, guanine, cholesterol), and diverse developmental and stress responses (gastrulation, cerebral cortex development, erythrocyte differentiation, xenobiotic/selenium response). This combination does not point to a single coherent function or pathway for the cluster, so an Unknown label with None confidence is appropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042391","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0010269","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0021987","count":2}]},{"hash":"931153499427587259","title":"Developmental growth with vitamin and xenobiotic responses","description":"This cluster centers on developmental processes such as liver regeneration, cartilage development, and general developmental growth, and on responses to nutrients and external stimuli (vitamin A, folic acid, tetrahydrofolate; xenobiotic and cytokine responses). The presence of dTTP and tetrahydrofolate biosynthesis links to nucleotide metabolism required for proliferative growth, suggesting a theme of growth coupled with nutrient- and environment-responsive signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":1},{"id":"GO:0097421","count":1},{"id":"GO:0006235","count":1},{"id":"GO:0048589","count":1},{"id":"GO:0000083","count":1}]},{"hash":"866464841297593538","title":"Unknown","description":"The GO terms are highly diverse, spanning several developmental processes (ureteric bud development, spermathecum morphogenesis, pupariation) and lipid/ metabolite regulation (cholesterol homeostasis, bile acid metabolism, HDL particle assembly, triglyceride storage regulation), plus broader regulatory activities (miRNA processing regulation, pinocytosis). With no clear, shared function tying the proteins together and no connections between them, there isn\u2019t a coherent theme to name a specific cluster function. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001657","count":3},{"id":"GO:0042632","count":2},{"id":"GO:0060750","count":2},{"id":"GO:0010891","count":2},{"id":"GO:1903799","count":2}]},{"hash":"883283109104381319","title":"Signaling and cytoskeletal dynamics","description":"The GO terms span signaling pathways (Wnt signaling, T cell receptor signaling) and apoptosis regulation, alongside cytoskeletal processes (filopodium assembly, GTPase activity) and mating projection growth. With no strong interactions among the four proteins, the common thread appears to be signaling events that coordinate cytoskeletal remodeling and cell fate decisions, supporting a broad label focused on signaling linked to cytoskeletal dynamics.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010796","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0043525","count":3}]},{"hash":"1819661225794844529","title":"Immune signaling and inflammatory response","description":"The cluster shows multiple terms tied to inflammation and immune signaling, including positive regulation of chemokine production, production of molecular mediators involved in inflammatory response, and GPCR signaling. While there are also terms linked to metabolism and other processes (e.g., chitin catabolic process, floral meristem growth), the strongest recurring theme is signaling and inflammatory mediator activity, suggesting these proteins function cooperatively in immune/inflammatory pathways.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0010080","count":2}]},{"hash":"269614064866298266","title":"Olfactory and pheromone signaling","description":"The presence of GO terms for sensory perception of smell and response to pheromone points to a chemosensory function as the core theme of this cluster, suggesting pheromone/odorant signaling. However, several other terms (electron transport chain, transport, V-type ATPase assembly) are less clearly connected to chemosensation, making the overall theme uncertain given the small, disconnected set of proteins. Confidence in this label is Low.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0019236","count":1}]},{"hash":"1962166182611890349","title":"Unknown","description":"The top GO terms are a scattered mix (oxidation-reduction, nutrient response, sporulation, methionine cycle, excretion, inflammatory response, fat differentiation) with several obsolete entries, and there are no edges connecting the proteins. There is no coherent shared function to define a specific cluster theme, so the label Unknown is most appropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0007584","count":1},{"id":"GO:0030435","count":1},{"id":"GO:1903758","count":1},{"id":"GO:0033353","count":1}]},{"hash":"2058080649635484611","title":"Unknown","description":"The four proteins span disparate processes (cell competition, synaptic vesicle endocytosis, and mitotic spindle checkpoint) with no shared high-level function or interaction, and include obsolete GO terms. There is no coherent theme to tie them together, so a specific functional label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035212","count":1},{"id":"GO:0048488","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0032515","count":1},{"id":"GO:0007094","count":1}]},{"hash":"834023363654055951","title":"Neural development and microtubule regulation","description":"This cluster centers on neural development and cytoskeletal regulation. Neural terms (olfactory nerve structure, vagus nerve development, Purkinje cell layer morphogenesis) dominate, along with microtubule-related processes (microtubule polymerization regulation, microtubule minus-end localization). The combined signal points to neural morphogenesis linked to the cytoskeleton.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031115","count":1},{"id":"GO:0021629","count":1},{"id":"GO:0000742","count":1},{"id":"GO:1904519","count":1},{"id":"GO:0070493","count":1}]},{"hash":"1659880102554909114","title":"ER Stress and Unfolded Protein Response","description":"The cluster centers on cellular responses to unfolded proteins and ER stress, highlighted by terms for the unfolded protein response, regulation of translation initiation during ER stress, and chaperone-assisted refolding and ERAD-related processes. While some terms are obsolete, the core theme is ER stress signaling and protein folding quality control, with additional links to oxidative and metal stress responses.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":3},{"id":"GO:0036494","count":2},{"id":"GO:0070389","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006626","count":2}]},{"hash":"257939335391305591","title":"Unknown","description":"The top GO terms span diverse biological contexts (invasive growth, fatty acid biosynthesis, nitrogen response, heterooligomerization, signaling, circadian rhythm, pollen hydration, nail development, sucrose response), with no clear single function uniting them across the four proteins. This lack of a cohesive theme makes a specific label unreliable, so Unknown is the best representation.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001403","count":2},{"id":"GO:0006633","count":1},{"id":"GO:0043562","count":1},{"id":"GO:0051291","count":1},{"id":"GO:0007165","count":1}]},{"hash":"1587099448110946997","title":"Unknown","description":"The GO terms are highly heterogeneous, covering larval fat body development, neuronal memory and synaptic plasticity, cell budding, regulation of transcription, hydrogen peroxide biosynthesis, and organ development\u2014without a single dominant shared function. Thus no coherent functional label can be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007504","count":1},{"id":"GO:0060316","count":1},{"id":"GO:0007114","count":1},{"id":"GO:2000678","count":1},{"id":"GO:0000742","count":1}]},{"hash":"428140477910679123","title":"Golgi\u2013vacuole vesicle trafficking","description":"These terms cluster around intracellular vesicle trafficking linked to the Golgi and vacuole, including intra-Golgi transport, Golgi-to-vacuole transport, ER-to-Golgi transport, and vacuole fusion. The presence of Golgi ribbon formation and protein targeting to vacuole supports a shared role in sorting and directing cargo through the secretory pathway to vacuolar compartments.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006891","count":1},{"id":"GO:0042144","count":1},{"id":"GO:0050882","count":1},{"id":"GO:0048280","count":1},{"id":"GO:0016236","count":1}]},{"hash":"1920041036652879466","title":"Retroviral integration and latency","description":"The terms point to retroviral life cycle steps: entry into host cells, integration of viral DNA, proviral latency, reverse transcription (RNA-templated DNA synthesis), and related DNA replication/recombination processes. Some terms also imply host interactions and RNA silencing countermeasures, supporting a cohesive retroviral theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903704","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0006260","count":1}]},{"hash":"1970428832980856863","title":"ER\u2013Golgi Vesicle Transport and Golgi Organization","description":"This cluster is dominated by GO terms for ER-to-Golgi vesicle transport, retrograde transport to the ER, vesicle fusion with the ER, and Golgi membrane organization, pointing to a coherent role in ER\u2013Golgi trafficking and Golgi dynamics. Noise terms related to development appear incidental rather than indicative of function. Thus, the label reflects the core shared function of the proteins in intracellular membrane trafficking and Golgi organization.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":1},{"id":"GO:0040027","count":1},{"id":"GO:0048279","count":1},{"id":"GO:1902953","count":1},{"id":"GO:1903358","count":1}]},{"hash":"2260218468196460","title":"RNA decay and nucleotide catabolism","description":"This cluster centers on RNA turnover and nucleotide degradation, with terms for deadenylation-independent mRNA decay, exonucleolytic RNA decay, and purine nucleotide catabolism (adenosine, diadenosine tetraphosphate). While some annotations are obsolete or peripheral (lipid catabolism, stress responses), the dominant theme points to RNA processing and nucleotide metabolism.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090503","count":1},{"id":"GO:2000757","count":1},{"id":"GO:0009154","count":1},{"id":"GO:0043928","count":1},{"id":"GO:0000012","count":1}]},{"hash":"164501467533791943","title":"Unknown","description":"The GO terms here cover stress response, cell cycle regulation, xenobiotic/dioxin metabolism, muscle differentiation, retinoic acid biosynthesis, inflammatory regulation, renal hormone regulation, ecdysone biosynthesis, retina vascular development, and ozone response\u2014an incoherent mix with no shared functional theme. With no edges and only a few proteins, there\u2019s no cohesive label to assign beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035902","count":2},{"id":"GO:1900087","count":2},{"id":"GO:0019341","count":2},{"id":"GO:2001037","count":2},{"id":"GO:0042904","count":2}]},{"hash":"406413423038994193","title":"Chaperone-Driven Protein Folding and Stabilization","description":"The cluster\u2019s strongest signals are chaperone-related: GO terms for chaperone-mediated protein complex assembly and protein refolding, plus protein stabilization. These point to a shared role in protein quality control and folding. Some telomere/telomerase and host-cell translocation terms appear as secondary or noisy annotations, but the core theme appears centered on chaperone-assisted maintenance of proteins.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051973","count":3},{"id":"GO:0050729","count":3},{"id":"GO:0051086","count":3},{"id":"GO:0050821","count":3},{"id":"GO:0032212","count":3}]},{"hash":"188608624765500912","title":"Unknown","description":"The GO terms are very diverse\u2014spanning vesicle formation regulation, ion-channel modulation, proteasomal/ERAD turnover, spindle pole biology, neuron axonogenesis, and various regulatory processes\u2014giving no clear unifying function.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905366","count":3},{"id":"GO:1902260","count":3},{"id":"GO:0032436","count":3},{"id":"GO:0030474","count":3},{"id":"GO:0048936","count":3}]},{"hash":"647202273153203008","title":"Developmental gene expression and cell-cycle regulation","description":"These terms point to a group involved in core gene expression (DNA-templated transcription, mRNA splicing) shared with embryonic development processes (gastrulation, neural tube closure). Additional signals for cell-cycle control (mitotic spindle orientation, cell cycle checkpoint) and chromatin regulation (histone modification, monoubiquitination) suggest coordination of transcriptional programs during development with cell-cycle events. Confidence: Medium","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0000398","count":1},{"id":"GO:0007369","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0040020","count":1}]},{"hash":"1447976442480759446","title":"Embryonic Neurodevelopment and Angiogenesis","description":"Most top GO terms cluster around embryonic development and neural patterning (forebrain development, neural tube closure, gastrulation), together with growth processes (multicellular organism growth) and angiogenesis, and a TGF-beta\u2013responsive stimulus. This suggests the proteins in the cluster participate in early development and vascular/neuronal tissue formation. A few terms relate to splicing, chromatin, and mitotic spindle orientation, which are less central to this theme, but do not outweigh the main developmental signal.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0001525","count":2}]},{"hash":"523180109991053690","title":"Microtubule-guided division and ciliogenesis","description":"This cluster centers on microtubule-based processes: spindle orientation, nuclear migration along microtubules, centrosome-associated microtubule anchoring, and non-motile cilium assembly, with supporting links to gamete development and neurogenesis. The shared theme is microtubule organization driving cell division and ciliogenesis across development.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007290","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0022008","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0048477","count":1}]},{"hash":"831429731044573291","title":"Meiosis DNA Damage Response and Repair","description":"The top terms include double-strand break repair involved in meiotic recombination and mitotic intra-S DNA damage checkpoint signaling, which together point to a coherent theme of DNA damage sensing and repair during meiosis and cell-cycle progression. Other terms present (eIF2\u03b1-mediated translational control, calcium signaling, lead ion response) may reflect broader stress-response connections but are less central to the primary theme. Overall, the cluster appears tied to DNA damage response in meiosis/cell-cycle context.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060316","count":3},{"id":"GO:0007114","count":3},{"id":"GO:0036496","count":3},{"id":"GO:1903799","count":3},{"id":"GO:0070940","count":3}]},{"hash":"1890916600172093808","title":"Developmental Transcription and Differentiation","description":"The top GO terms point to DNA-templated transcription and several differentiation-related processes, including endodermal fate determination, atrial septum morphogenesis, megakaryocyte differentiation, and sprouting angiogenesis, with an additional signal related to interleukin-4 response. This suggests a cluster of proteins engaged in transcriptional regulation during development and lineage differentiation, with some immune signaling involvement. A few terms (e.g., plant defense and chromatin silencing) are less coherent with vertebrate development, but the main theme appears to be transcriptional control guiding cellular differentiation and tissue formation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0045654","count":2},{"id":"GO:0007493","count":2},{"id":"GO:0003290","count":2},{"id":"GO:0071353","count":2}]},{"hash":"1342151086973662730","title":"Purine nucleotide metabolism and salvage","description":"This cluster centers on AMP salvage, purine ribonucleotide interconversion, and nucleotide phosphorylation (including ADP and CDP biosynthesis), pointing to a cohesive theme of nucleotide metabolism and biosynthesis. Brain and liver development terms appear as outliers relative to the core metabolic signals, suggesting they are broader annotations rather than defining functions of the cluster. Overall, the proteins are best described by nucleotide metabolism processes.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044209","count":3},{"id":"GO:0015951","count":3},{"id":"GO:0046940","count":3},{"id":"GO:0046705","count":3},{"id":"GO:0007420","count":3}]},{"hash":"1074302030479294692","title":"NAD/NADP metabolism and amino acid biosynthesis","description":"The top GO terms point to NAD+ and NADP+ metabolic processes, polyphosphate metabolism, and amino acid\u2013related pathways (arginine, citrulline, urea cycle), with phosphorylation also represented. This suggests a small metabolic module centered on nucleotide cofactor metabolism and nitrogen-containing amino acid biosynthesis, rather than a single signaling or transport function. The presence of a few broader or tangential terms likely reflects shared metabolic regulation rather than a distinct specialized pathway. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006797","count":2},{"id":"GO:0019674","count":2},{"id":"GO:0006741","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0000053","count":1}]},{"hash":"290556123575659126","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":3},{"id":"GO:1904574","count":2},{"id":"GO:0000398","count":2},{"id":"GO:2000616","count":2},{"id":"GO:0006265","count":2}]},{"hash":"1241793562276491582","title":"mRNA maturation and translation regulation","description":"The proteins are linked by post-transcriptional roles: spliceosome-mediated mRNA splicing, mRNA export, mRNA modification, and regulation of translational initiation (including formation of the translation preinitiation complex) and ncRNA-mediated silencing. This ensemble points to a coherent module centered on mRNA processing and control of translation, rather than other cellular processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006406","count":3},{"id":"GO:1900363","count":3}]},{"hash":"1685149311211798413","title":"RNA Processing and Splicing Machinery","description":"The proteins show multiple RNA-centric roles: maturation of SSU-rRNA, tRNA processing, mRNA splicing via the spliceosome, spliceosomal complex assembly, and nuclear import, with related RNA decay/processing (deadenylation-dependent decapping) and P-body assembly. Although there are peripheral stress response terms, the dominant signal is RNA maturation and splicing machinery, suggesting a nucleus-focused RNA processing cluster.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030490","count":2},{"id":"GO:0008033","count":1},{"id":"GO:1990141","count":1},{"id":"GO:0045292","count":1},{"id":"GO:0051170","count":1}]},{"hash":"1124495666437413177","title":"Bacterial cell envelope biosynthesis","description":"The top GO terms are dominated by peptidoglycan, lipopolysaccharide, and lipid A biosynthesis, plus nucleotide-sugar biosynthetic pathways (UDP-N-acetylglucosamine, GDP-mannose) used for cell wall components, with a note on antibiotic response and general cell wall biogenesis. This points to a cluster of proteins involved in building the bacterial cell envelope rather than other cellular processes.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0019877","count":2},{"id":"GO:0009252","count":2},{"id":"GO:0009272","count":2},{"id":"GO:0000902","count":2}]},{"hash":"596628567615374787","title":"Unknown","description":"No shared GO terms or functional signals are detected among the proteins; Top Terms list is empty and the interaction graph is sparse (2 edges, no triangles) with a maximum degree of 2, making it impossible to infer a cohesive function. Therefore a generic Unknown label is appropriate.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"2272437415304940819","title":"Embryonic Development and Morphogenesis","description":"Top GO terms center on embryonic and organ development (placenta, endocrine system, left/right patterning) and tissue morphogenesis (cartilage, EMT in heart cushion, trophoblast differentiation). This combination suggests proteins involved in early development and tissue remodeling, with inflammatory/coagulation terms likely secondary or context-dependent.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060707","count":2}]},{"hash":"1855878322736561989","title":"Neuronal development and GPCR signaling","description":"This cluster\u2019s GO terms center on neural morphogenesis and signaling, including substantia nigra development, regulation of nerve branching morphogenesis, and G protein-coupled receptor signaling. Despite a few outlier terms, the strongest cohesive theme is neural development coupled with GPCR-driven signaling, suggesting a neuronally focused functional unit.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071851","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0007186","count":2},{"id":"GO:0060999","count":2}]},{"hash":"1131675838223268250","title":"Ossification and bone formation regulators","description":"The GO terms cluster around BMP/SMAD signaling regulation and ossification processes (positive regulation of ossification, negative regulation of osteoclast differentiation), pointing to bone formation and skeletal development as the core theme, with some related developmental processes. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":1},{"id":"GO:0060213","count":1},{"id":"GO:0045778","count":1},{"id":"GO:0045671","count":1},{"id":"GO:0017148","count":1}]},{"hash":"1698396934019124558","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning DNA-templated transcription, insect/plant development (antennal and seed-related terms), plant secondary metabolism, and bacterial lipid biosynthesis/transport, with no connecting function or interaction pattern (no edges). This mixture across taxa and processes provides no coherent shared biology for a confident functional label, so Unknown with None is most appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0045316","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0009698","count":1}]},{"hash":"1186533205810180842","title":"Potassium transport and membrane potential regulation","description":"Based on the GO terms, the dominant signal is ion homeostasis and electrical excitability: multiple terms point to potassium ion transmembrane transport and to regulation and stabilization of membrane potential, including resting potential maintenance and repolarization. Other terms mention saliva secretion and sensory processes, which can arise from tissues where ion gradients drive signaling and secretion. Overall, the cluster appears to group proteins involved in potassium handling and membrane potential control rather than a single saliva- or pain-specific process.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046541","count":3},{"id":"GO:0071502","count":2},{"id":"GO:0050976","count":2},{"id":"GO:0030322","count":2},{"id":"GO:0030007","count":2}]},{"hash":"540978263225175263","title":"Lipids, heme, and amino acid biosynthesis","description":"This cluster shows GO terms spanning lipid biosynthesis (sphingomyelin, sphinganine), heme biosynthesis, and multiple amino acid biosynthetic processes (tyrosine, aspartate, phenylalanine). The proteins appear annotated to diverse biosynthetic pathways rather than a single process, so the unifying theme is biosynthesis across lipid, heme, and amino acid classes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006686","count":2},{"id":"GO:0033585","count":2},{"id":"GO:0006783","count":2},{"id":"GO:0046511","count":2},{"id":"GO:0015908","count":2}]},{"hash":"1745762267788930259","title":"Unknown","description":"The terms span embryonic development (in utero development, gastrulation, cerebral cortex development), metabolism (TCA cycle, cholesterol metabolism), and various stress/response processes (lipopolysaccharide, xenobiotic) plus transcriptional regulation, with no single cohesive function tying them together. Therefore no specific, representative label can be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0042391","count":1},{"id":"GO:0006099","count":1}]},{"hash":"1565162408536017684","title":"Proteostasis and stress response","description":"The GO terms converge on cellular protein quality control and stress adaptation, including ER unfolded protein response, chaperone-mediated protein assembly, autophagosome maturation, stress granule disassembly, and heat acclimation. Some terms (cell division, transformation competence) are less connected and likely peripheral. Overall, the cluster appears to reflect general proteostasis and stress-response programs rather than a single specific process.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0016558","count":2},{"id":"GO:0035617","count":2},{"id":"GO:0030420","count":2}]},{"hash":"1123158441753253083","title":"Small-molecule metabolism and nutrient response","description":"The cluster shows enrichment for various small-molecule catabolic processes (retinol, ethanol, 4-hydroxyphenylacetate, GABA shunt) and nutrient-related responses (response to nutrient, glycine betaine biosynthesis from choline), suggesting a core theme of organic compound metabolism and nutrient adaptation. Some GO terms (endothelial proliferation, olfactory pit development) appear unrelated, likely annotation noise or cross-species misannotations, but the dominant signal points to metabolic processing of diverse small molecules. ","confidence":"Low","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":3},{"id":"GO:0006068","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0006540","count":3},{"id":"GO:0001936","count":3}]},{"hash":"2242872027356966697","title":"Immune and Blood Cell Development","description":"The top GO terms are dominated by immune and hematopoietic processes (inflammatory response, NK cell proliferation, GM-CSF response, erythrocyte differentiation, regulation of hemocyte differentiation), suggesting a shared role in immune and blood cell development. A few terms (muscle channel clustering, ectodermal fate commitment) are less coherent with this theme, but the prevailing signals point toward immune/blood lineage functions. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0001662","count":2},{"id":"GO:0030218","count":1},{"id":"GO:0045610","count":1},{"id":"GO:0071340","count":1}]},{"hash":"2106546382640911586","title":"Diverse small-molecule metabolism and stress response","description":"The top GO terms point to metabolism of a range of small molecules (retinol, sorbitol, ethanol, xylitol, furaldehyde, prostaglandin) and related catabolic processes, with additional hints of LPS and nitrosative stress responses. This suggests a cluster of proteins involved in detoxification and processing of diverse small molecules, rather than a single cohesive pathway. The absence of edges further supports a broad, heterogeneous set of functions; hence the label reflects a general theme of varied metabolism with stress response.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":1},{"id":"GO:0006062","count":1},{"id":"GO:0006068","count":1},{"id":"GO:0006069","count":1},{"id":"GO:0033859","count":1}]},{"hash":"546999595828052615","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around embryogenesis, placental development, organ morphogenesis, left-right patterning, and differentiation processes, with a few housekeeping terms. This suggests the proteins participate broadly in embryonic development and tissue formation rather than a single, tight pathway.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060972","count":3}]},{"hash":"2097272151415938311","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0022417","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0006458","count":2}]},{"hash":"940476921570508426","title":"Embryonic Development and Morphogenesis","description":"These GO terms point to developmental processes across multiple tissues and organs, including placental differentiation, cartilage morphogenesis, endocrine development, left-right patterning, pancreatic cell development, and EMT in heart formation. The common theme is embryogenesis and tissue morphogenesis rather than a single pathway, suggesting the proteins participate in broad developmental differentiation and patterning. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060972","count":1}]},{"hash":"1210893456548246587","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051083","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0000086","count":1},{"id":"GO:0048575","count":1},{"id":"GO:1900087","count":1}]},{"hash":"70490344791809296","title":"Oxidative stress response and organelle trafficking","description":"The GO terms point to a stress-related theme: oxidative stress\u2013induced intrinsic apoptotic signaling and reduced mitochondrial membrane potential, with an additional link to ER-to-Golgi vesicle transport. One term about negative regulation of L-glutamate import adds a metabolic angle. Together, they suggest a loose cluster around cellular stress responses and organelle trafficking rather than a single precise function.","confidence":"Low","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002037","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0008631","count":1},{"id":"GO:0010917","count":1}]},{"hash":"241179843770591868","title":"Unknown","description":"The GO terms are highly diverse, spanning glycosylation, ion transport, lipid and phosphatidylcholine metabolism, mitochondrial fusion regulation, microvillus assembly, P granule organization, and hematopoietic differentiation, with no clear shared function across all three proteins. This lack of a unifying theme makes it inappropriate to assign a specific, representative label. ","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015693","count":1},{"id":"GO:0018279","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0016042","count":1},{"id":"GO:0010636","count":1}]},{"hash":"1125217867021445066","title":"Inflammation and coagulation with tissue remodeling","description":"The proteins group around inflammatory and hemostatic processes, including blood coagulation, complement activation, leukocyte migration, cytokine regulation, and tissue remodeling (angiogenesis and collagen catabolism). These terms collectively point to a vascular inflammatory/hemostatic response followed by remodeling, rather than a single, narrow function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0051919","count":2},{"id":"GO:0002523","count":2},{"id":"GO:0050754","count":2},{"id":"GO:0006958","count":2}]},{"hash":"1058185884212331397","title":"Unknown","description":"The top GO terms are highly mixed, ranging from vascular development and signaling (endothelial differentiation, VEGF signaling, p38MAPK) to seemingly unrelated processes (ATP synthesis, auxin biosynthesis, nitrogen fixation, bone resorption). With only 3 proteins and no edges, there isn\u2019t a clear, unified function linking them, so a concise, unknown label is most appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045602","count":1},{"id":"GO:1900745","count":1},{"id":"GO:1900747","count":1},{"id":"GO:0042773","count":1},{"id":"GO:0009851","count":1}]},{"hash":"529812803549531925","title":"Cilia\u2013Centrosome\u2013Cell Cycle Regulation","description":"The top GO terms converge on ciliogenesis (cilium assembly, intraflagellar transport), centrosome localization, and cell cycle control (spindle assembly checkpoint, cell cycle). These facets are functionally connected through centrosome/ciliary machinery and their role in timing and symmetry (left-right determination). A few terms like iron transport, ribosomal export, and cold acclimation appear more peripheral or noisy, but the core cluster supports a cilia-centrosome\u2013cell cycle theme.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902017","count":1},{"id":"GO:0035735","count":1},{"id":"GO:0090267","count":1},{"id":"GO:0051642","count":1},{"id":"GO:0007368","count":1}]},{"hash":"2073422358535479892","title":"Developmental mitotic regulation","description":"The set includes terms related to microtubule dynamics (negative regulation of microtubule polymerization; spindle orientation), cell cycle control (regulation of cell cycle checkpoint; regulation of meiotic nuclear division), and developmental processes (gastrulation, neural tube closure). This suggests a theme around mitosis/spindle biology as it relates to development, though a single precise function is not dominant across terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031115","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0007369","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0040020","count":1}]}]