{"hash":"1641141824713329834","title":"RNA Capping and Methylation","description":"This cluster centers on RNA processing and methylation, highlighted by mRNA capping (7-methylguanosine cap), RNA guanine-N7 methylation, and tRNA wobble uridine modification, as well as protein methylation activities (N-terminal trimethylation and lysine monomethylation). The presence of transcription-related terms further supports a role in gene expression regulation. Together these signals point to RNA modification and associated methylation pathways as the core function of this cluster.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"members":[{"accession":"XP_001636710.2","go_terms":["GO:0036265","GO:0006718","GO:0035572","GO:0035573","GO:0001887","GO:0014075","GO:0002347","GO:0070555","GO:0036068","GO:0018012","GO:0018013","GO:0006972","GO:0042220","GO:0002098","GO:0019505","GO:0035902","GO:0006370","GO:0009877","GO:0046690","GO:1901052","GO:0009236","GO:0017000","GO:0035690","GO:0006656","GO:0019919","GO:0009102","GO:0030488","GO:0016049","GO:0006744","GO:0010189","GO:0016126","GO:0043985","GO:0070476","GO:0000056","GO:0001300","GO:0090398","GO:0030961","GO:0042372","GO:0009234","GO:0009060","GO:0031167","GO:0018364","GO:0018026","GO:0018027","GO:0006596","GO:0000154"]},{"accession":"XP_032227398.1","go_terms":[]},{"accession":"XP_048575869.1","go_terms":["GO:0061179","GO:0042775"]},{"accession":"XP_032236876.2","go_terms":["GO:0006729","GO:0006558","GO:0051289","GO:0051291","GO:0043496","GO:0006351","GO:0055114"]},{"accession":"XP_001640298.2","go_terms":["GO:0006642","GO:0036153","GO:2000480","GO:0019433","GO:0010898","GO:0046338","GO:0034638"]},{"accession":"XP_048584912.1","go_terms":["GO:0000462","GO:0006412"]},{"accession":"XP_001631469.2","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0050689","GO:0071360","GO:0045087","GO:0008277","GO:0051301","GO:0048312","GO:0055059","GO:0009938"]},{"accession":"XP_001641723.2","go_terms":["GO:0090502","GO:0001682","GO:0043144","GO:0010884","GO:0071222","GO:1900119","GO:1903003","GO:0032435","GO:1903799","GO:0042149","GO:0010656","GO:2000379","GO:0045019","GO:1900261","GO:0071356","GO:0045766","GO:0045600","GO:0031397","GO:0044828","GO:2000627","GO:0098586","GO:1902714","GO:1904628","GO:1904468","GO:0061014","GO:0050713","GO:0061158","GO:0055118","GO:0042307","GO:0042347","GO:1990869","GO:1900016","GO:0010595","GO:0000294","GO:0071347","GO:1903936","GO:0032088","GO:0002230","GO:1900745","GO:1904637","GO:1900165"]},{"accession":"XP_032218377.2","go_terms":["GO:0035999","GO:0019556","GO:0019557"]},{"accession":"XP_001628890.2","go_terms":["GO:1904960","GO:0033132","GO:0008535"]},{"accession":"XP_001632795.2","go_terms":["GO:2000984"]},{"accession":"XP_001633338.3","go_terms":["GO:0070584","GO:0050881","GO:0019216","GO:0031413","GO:0050905"]},{"accession":"XP_001638902.3","go_terms":["GO:1902042","GO:1902044","GO:0032392","GO:0034137","GO:1903672","GO:1990774","GO:0043388","GO:2000819","GO:0034587","GO:0007140","GO:0002643","GO:0002281","GO:0043046","GO:0007129","GO:0002437","GO:0097350","GO:0045819","GO:2000426","GO:0032727","GO:0035767","GO:0017055","GO:2001200","GO:0032425","GO:0032728","GO:0032072","GO:0034145","GO:0002840","GO:0007289","GO:0045063","GO:0050718","GO:0045654","GO:0002270","GO:0045578","GO:0006391","GO:0001935","GO:0048545","GO:0035711","GO:2001237","GO:0033153","GO:0061303","GO:0060009","GO:0001755","GO:0061386","GO:0061145","GO:0048866","GO:0001828","GO:0043044","GO:0030916","GO:0032332","GO:2000741","GO:0045662","GO:0003415","GO:0072193","GO:0072197","GO:0048298","GO:0060532","GO:2000726","GO:0061010","GO:0003290","GO:0060018","GO:0001841","GO:0003357","GO:0061153","GO:0003211","GO:0046533","GO:0003289","GO:0055057","GO:0021538","GO:0048484","GO:0071864","GO:0071866","GO:0010909","GO:0003203","GO:0071353","GO:0060784","GO:0035914","GO:0030879","GO:0035622","GO:0048557","GO:0048709","GO:0048627","GO:0048625","GO:0014009","GO:0035019","GO:0070898","GO:0060174","GO:0071504","GO:0043049","GO:0007422","GO:0060807","GO:0006351","GO:0021943","GO:0007493","GO:0031018","GO:0021903","GO:0032808","GO:0045586","GO:0060956","GO:0090579","GO:0003308","GO:0000122","GO:0044334","GO:0072091","GO:1902262","GO:0003413","GO:0007548","GO:0060214","GO:0090139","GO:0072190","GO:2000043","GO:0090190","GO:0071899","GO:0071560","GO:0060517","GO:0033234","GO:0048546","GO:0070318","GO:0048619","GO:2001111","GO:0042662","GO:0060221","GO:0072289","GO:0001195","GO:0010197","GO:0043586","GO:0032696","GO:0070384","GO:2000761","GO:0090090","GO:0014718","GO:0061138","GO:0019100","GO:0060729","GO:0044336","GO:0003142","GO:0072034","GO:0010452","GO:0030538","GO:2000020","GO:0060534","GO:0021861"]},{"accession":"XP_001639116.3","go_terms":["GO:0070124"]},{"accession":"XP_032225527.1","go_terms":["GO:0033617"]},{"accession":"XP_032241737.2","go_terms":["GO:0019062","GO:0036265","GO:0002128","GO:0000466","GO:0000453","GO:0039654","GO:0039520","GO:0039694","GO:0097309","GO:0006370","GO:0000463","GO:0002181","GO:0097310"]},{"accession":"XP_048577125.1","go_terms":["GO:0048738","GO:0055114"]}],"graph":[["XP_001638902.3","XP_001628890.2",0.98],["XP_001638902.3","XP_001631469.2",0.964],["XP_001638902.3","XP_001632795.2",0.954],["XP_001638902.3","XP_001633338.3",0.944],["XP_001638902.3","XP_001636710.2",0.914],["XP_001638902.3","XP_032218377.2",0.977],["XP_001638902.3","XP_001639116.3",0.922],["XP_001638902.3","XP_001640298.2",0.968],["XP_001638902.3","XP_001641723.2",0.969],["XP_001638902.3","XP_032225527.1",0.983],["XP_001638902.3","XP_032227398.1",0.964],["XP_001638902.3","XP_032236876.2",0.98],["XP_001638902.3","XP_032241737.2",0.972],["XP_001638902.3","XP_048575869.1",0.976],["XP_001638902.3","XP_048577125.1",0.962],["XP_001638902.3","XP_048584912.1",0.981],["XP_032236876.2","XP_001628890.2",0.98],["XP_032236876.2","XP_001631469.2",0.974],["XP_032236876.2","XP_001632795.2",0.94],["XP_032236876.2","XP_001633338.3",0.921],["XP_032236876.2","XP_001636710.2",0.969],["XP_032236876.2","XP_001639116.3",0.954],["XP_032236876.2","XP_001640298.2",0.958],["XP_032236876.2","XP_001641723.2",0.952],["XP_032236876.2","XP_032218377.2",0.982],["XP_032236876.2","XP_032225527.1",0.905],["XP_032236876.2","XP_032227398.1",0.975],["XP_032236876.2","XP_032241737.2",0.945],["XP_032236876.2","XP_048584912.1",0.926],["XP_032236876.2","XP_048577125.1",0.976],["XP_032236876.2","XP_048575869.1",0.929],["XP_048575869.1","XP_001628890.2",0.938],["XP_048575869.1","XP_001631469.2",0.971],["XP_048575869.1","XP_001632795.2",0.892],["XP_048575869.1","XP_001633338.3",0.857],["XP_048575869.1","XP_001636710.2",0.975],["XP_048575869.1","XP_001639116.3",0.982],["XP_048575869.1","XP_001640298.2",0.955],["XP_048575869.1","XP_001641723.2",0.968],["XP_048575869.1","XP_032218377.2",0.971],["XP_048575869.1","XP_032225527.1",0.874],["XP_048575869.1","XP_032227398.1",0.966],["XP_048575869.1","XP_032241737.2",0.98],["XP_048575869.1","XP_048577125.1",0.976],["XP_048575869.1","XP_048584912.1",0.972],["XP_001640298.2","XP_001628890.2",0.802],["XP_001640298.2","XP_001631469.2",0.958],["XP_001640298.2","XP_001632795.2",0.98],["XP_001640298.2","XP_001633338.3",0.967],["XP_001640298.2","XP_001636710.2",0.917],["XP_001640298.2","XP_001639116.3",0.968],["XP_001640298.2","XP_001641723.2",0.964],["XP_001640298.2","XP_032218377.2",0.989],["XP_001640298.2","XP_032241737.2",0.915],["XP_001640298.2","XP_032225527.1",0.957],["XP_001640298.2","XP_032227398.1",0.987],["XP_001640298.2","XP_048584912.1",0.988],["XP_001640298.2","XP_048577125.1",0.906],["XP_001631469.2","XP_001628890.2",0.947],["XP_001631469.2","XP_032218377.2",0.894],["XP_001631469.2","XP_001641723.2",0.906],["XP_001631469.2","XP_001639116.3",0.911],["XP_001631469.2","XP_001636710.2",0.932],["XP_001631469.2","XP_001632795.2",0.963],["XP_001631469.2","XP_001633338.3",0.977],["XP_001631469.2","XP_032241737.2",0.954],["XP_001631469.2","XP_032225527.1",0.991],["XP_001631469.2","XP_032227398.1",0.95],["XP_001631469.2","XP_048584912.1",0.967],["XP_001631469.2","XP_048577125.1",0.946],["XP_001641723.2","XP_001628890.2",0.811],["XP_001641723.2","XP_001632795.2",0.975],["XP_001641723.2","XP_001633338.3",0.932],["XP_001641723.2","XP_001636710.2",0.969],["XP_001641723.2","XP_001639116.3",0.989],["XP_001641723.2","XP_032218377.2",0.846],["XP_001641723.2","XP_032241737.2",0.973],["XP_001641723.2","XP_032225527.1",0.953],["XP_001641723.2","XP_032227398.1",0.898],["XP_001641723.2","XP_048584912.1",0.992],["XP_001641723.2","XP_048577125.1",0.878],["XP_048584912.1","XP_001628890.2",0.853],["XP_048584912.1","XP_001632795.2",0.99],["XP_048584912.1","XP_001633338.3",0.968],["XP_048584912.1","XP_001636710.2",0.922],["XP_048584912.1","XP_001639116.3",0.86],["XP_048584912.1","XP_032218377.2",0.969],["XP_048584912.1","XP_032225527.1",0.974],["XP_048584912.1","XP_032227398.1",0.988],["XP_048584912.1","XP_032241737.2",0.982],["XP_048584912.1","XP_048577125.1",0.972],["XP_032241737.2","XP_001628890.2",0.974],["XP_032241737.2","XP_001632795.2",0.934],["XP_032241737.2","XP_001633338.3",0.898],["XP_032241737.2","XP_001636710.2",0.912],["XP_032241737.2","XP_001639116.3",0.987],["XP_032241737.2","XP_032218377.2",0.963],["XP_032241737.2","XP_032225527.1",0.947],["XP_032241737.2","XP_032227398.1",0.911],["XP_032241737.2","XP_048577125.1",0.785],["XP_001633338.3","XP_001628890.2",0.921],["XP_001633338.3","XP_001632795.2",0.937],["XP_001633338.3","XP_001636710.2",0.78],["XP_001633338.3","XP_001639116.3",0.971],["XP_001633338.3","XP_032218377.2",0.97],["XP_001633338.3","XP_032225527.1",0.968],["XP_001633338.3","XP_032227398.1",0.981],["XP_001633338.3","XP_048577125.1",0.885],["XP_032225527.1","XP_001628890.2",0.878],["XP_032225527.1","XP_001632795.2",0.982],["XP_032225527.1","XP_001636710.2",0.987],["XP_032225527.1","XP_001639116.3",0.973],["XP_032225527.1","XP_032218377.2",0.98],["XP_032225527.1","XP_032227398.1",0.965],["XP_032225527.1","XP_048577125.1",0.942],["XP_001632795.2","XP_001628890.2",0.96],["XP_001632795.2","XP_001636710.2",0.988],["XP_001632795.2","XP_001639116.3",0.985],["XP_001632795.2","XP_032218377.2",0.968],["XP_001632795.2","XP_032227398.1",0.984],["XP_001632795.2","XP_048577125.1",0.981],["XP_048577125.1","XP_001628890.2",0.909],["XP_048577125.1","XP_001636710.2",0.99],["XP_048577125.1","XP_001639116.3",0.945],["XP_048577125.1","XP_032218377.2",0.98],["XP_048577125.1","XP_032227398.1",0.972],["XP_032227398.1","XP_001628890.2",0.842],["XP_032227398.1","XP_001636710.2",0.961],["XP_032227398.1","XP_001639116.3",0.979],["XP_032227398.1","XP_032218377.2",0.985],["XP_001636710.2","XP_001628890.2",0.952],["XP_001636710.2","XP_001639116.3",0.921],["XP_001636710.2","XP_032218377.2",0.936],["XP_001628890.2","XP_001639116.3",0.978],["XP_001628890.2","XP_032218377.2",0.787],["XP_032218377.2","XP_001639116.3",0.987]],"all_go_terms":{"GO:0090398":1,"GO:0018012":1,"GO:0018026":1,"GO:0014075":1,"GO:0006744":1,"GO:0002098":1,"GO:0035690":1,"GO:0000154":1,"GO:0006972":1,"GO:0018364":1,"GO:0042372":1,"GO:0016049":1,"GO:0006656":1,"GO:0042220":1,"GO:0009060":1,"GO:0030961":1,"GO:0019505":1,"GO:0010189":1,"GO:0070555":1,"GO:0030488":1,"GO:0001300":1,"GO:0035572":1,"GO:0006596":1,"GO:1901052":1,"GO:0035573":1,"GO:0016126":1,"GO:0036068":1,"GO:0001887":1,"GO:0017000":1,"GO:0009234":1,"GO:0019919":1,"GO:0009877":1,"GO:0036265":2,"GO:0002347":1,"GO:0000056":1,"GO:0006718":1,"GO:0046690":1,"GO:0018027":1,"GO:0035902":1,"GO:0043985":1,"GO:0070476":1,"GO:0006370":2,"GO:0018013":1,"GO:0009236":1,"GO:0009102":1,"GO:0031167":1,"GO:0042775":1,"GO:0061179":1,"GO:0051291":1,"GO:0006558":1,"GO:0006351":2,"GO:0051289":1,"GO:0055114":2,"GO:0043496":1,"GO:0006729":1,"GO:2000480":1,"GO:0036153":1,"GO:0034638":1,"GO:0019433":1,"GO:0046338":1,"GO:0006642":1,"GO:0010898":1,"GO:0006412":1,"GO:0000462":1,"GO:0046661":1,"GO:0030850":1,"GO:0008277":1,"GO:0055059":1,"GO:0048312":1,"GO:0050689":1,"GO:0006463":1,"GO:0045087":1,"GO:0009938":1,"GO:0071357":1,"GO:0071360":1,"GO:0051301":1,"GO:0043144":1,"GO:0090502":1,"GO:0010595":1,"GO:0071347":1,"GO:0044828":1,"GO:1990869":1,"GO:2000627":1,"GO:1900119":1,"GO:0071356":1,"GO:0010656":1,"GO:2000379":1,"GO:0042307":1,"GO:0000294":1,"GO:0098586":1,"GO:1903799":1,"GO:1900261":1,"GO:1903936":1,"GO:0061014":1,"GO:1900745":1,"GO:0055118":1,"GO:0042347":1,"GO:0050713":1,"GO:0010884":1,"GO:0045766":1,"GO:0042149":1,"GO:0045019":1,"GO:0045600":1,"GO:0031397":1,"GO:1904468":1,"GO:0071222":1,"GO:0032435":1,"GO:0002230":1,"GO:0061158":1,"GO:0032088":1,"GO:0001682":1,"GO:1900016":1,"GO:1902714":1,"GO:1900165":1,"GO:1904637":1,"GO:1904628":1,"GO:1903003":1,"GO:0035999":1,"GO:0019556":1,"GO:0019557":1,"GO:0008535":1,"GO:1904960":1,"GO:0033132":1,"GO:2000984":1,"GO:0019216":1,"GO:0070584":1,"GO:0050905":1,"GO:0050881":1,"GO:0031413":1,"GO:0032072":1,"GO:0032728":1,"GO:0060534":1,"GO:0061303":1,"GO:1902044":1,"GO:0035914":1,"GO:2000726":1,"GO:0090579":1,"GO:0070318":1,"GO:0045662":1,"GO:0000122":1,"GO:0060956":1,"GO:0048866":1,"GO:0071866":1,"GO:0003357":1,"GO:0021943":1,"GO:0010452":1,"GO:0060018":1,"GO:0071504":1,"GO:0060784":1,"GO:0034137":1,"GO:0003211":1,"GO:0061153":1,"GO:0010909":1,"GO:0070898":1,"GO:0043586":1,"GO:0090139":1,"GO:0045578":1,"GO:1990774":1,"GO:0060729":1,"GO:0043046":1,"GO:0048625":1,"GO:0030879":1,"GO:0042662":1,"GO:0048545":1,"GO:0003142":1,"GO:0071353":1,"GO:0044334":1,"GO:2000819":1,"GO:0017055":1,"GO:0072091":1,"GO:0060214":1,"GO:2000761":1,"GO:0061386":1,"GO:2000426":1,"GO:0021903":1,"GO:0044336":1,"GO:2000020":1,"GO:0072193":1,"GO:0033234":1,"GO:0021538":1,"GO:0002281":1,"GO:0072034":1,"GO:0007289":1,"GO:0002840":1,"GO:0071864":1,"GO:0045586":1,"GO:0032727":1,"GO:0048298":1,"GO:0048709":1,"GO:0072190":1,"GO:0033153":1,"GO:0035019":1,"GO:0035711":1,"GO:0045654":1,"GO:0003290":1,"GO:0090090":1,"GO:0048546":1,"GO:0060517":1,"GO:2000043":1,"GO:0014009":1,"GO:0043049":1,"GO:0007548":1,"GO:0002270":1,"GO:0046533":1,"GO:0001841":1,"GO:0007140":1,"GO:0048627":1,"GO:0003413":1,"GO:0001195":1,"GO:0006391":1,"GO:0002643":1,"GO:0090190":1,"GO:0001755":1,"GO:0043044":1,"GO:0030916":1,"GO:0045063":1,"GO:0048484":1,"GO:0071899":1,"GO:0060532":1,"GO:2001111":1,"GO:0035767":1,"GO:1902262":1,"GO:0007129":1,"GO:2001200":1,"GO:0032392":1,"GO:0003415":1,"GO:0048557":1,"GO:0060807":1,"GO:0007493":1,"GO:0001828":1,"GO:0035622":1,"GO:0061010":1,"GO:0032808":1,"GO:0050718":1,"GO:0002437":1,"GO:0055057":1,"GO:0034587":1,"GO:0010197":1,"GO:2000741":1,"GO:0061145":1,"GO:0021861":1,"GO:0014718":1,"GO:0001935":1,"GO:0060009":1,"GO:0071560":1,"GO:0032425":1,"GO:0003289":1,"GO:0019100":1,"GO:0070384":1,"GO:0034145":1,"GO:1903672":1,"GO:0003203":1,"GO:0032332":1,"GO:0060221":1,"GO:0031018":1,"GO:0097350":1,"GO:0030538":1,"GO:0061138":1,"GO:0045819":1,"GO:1902042":1,"GO:0060174":1,"GO:0048619":1,"GO:2001237":1,"GO:0072197":1,"GO:0072289":1,"GO:0007422":1,"GO:0032696":1,"GO:0043388":1,"GO:0003308":1,"GO:0070124":1,"GO:0033617":1,"GO:0039654":1,"GO:0000466":1,"GO:0097309":1,"GO:0000453":1,"GO:0097310":1,"GO:0039520":1,"GO:0002181":1,"GO:0019062":1,"GO:0039694":1,"GO:0002128":1,"GO:0000463":1,"GO:0048738":1},"recipe_readded":[]}