[{"hash":"1527542772146216257","title":"Autonomic GPCR Signaling and Thermogenesis","description":"The cluster shows strong representation of GO terms tied to autonomic regulation and metabolic responses: positive regulation of blood pressure, acetylcholine metabolism, and GPCR signaling activating adenylate cyclase, plus thermogenic and temperature-responsive processes. The presence of diet-induced thermogenesis and cellular response to temperature stimulus suggests involvement in energy expenditure, while regulation of pain perception and negative regulation of chemokine production hints at broader neuromodulatory and inflammatory links. The electron transport chain term aligns with energy metabolism supporting thermogenesis.","confidence":"Medium","size":29,"edges":8,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":25},{"id":"GO:0022900","count":25},{"id":"GO:0010579","count":25},{"id":"GO:0035025","count":24},{"id":"GO:0002024","count":24}]},{"hash":"1897214115543660710","title":"Unknown","description":"The GO terms are highly diverse, including GTPase regulation, chromatin/h subtelomeric formation, heart development, actin crosslinking, synaptic potentiation, Fc-epsilon receptor signaling, protein oligomerization, ubiquitin-dependent proteolysis, and historical RNAP II CTD phosphorylation. There is no single coherent function or pathway uniting these proteins, and only a few terms share broad categories, making it unclear what common function defines this cluster. Therefore, Unknown with None confidence.","confidence":"","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0060291","count":2}]},{"hash":"1890215024729400270","title":"Tissue development with inflammatory signaling","description":"The proteins show strong associations with diverse developmental processes (Leydig cell differentiation, vagina development, mammary gland alveolus development, placenta development, fat cell differentiation) and transcriptional regulation, along with signaling pathways (retinoic acid response, p38MAPK cascade) and immune-related responses (lipopolysaccharide response, negative regulation of inflammatory response). This points to a cluster of factors coordinating tissue differentiation with inflammatory signaling.","confidence":"Medium","size":29,"edges":111,"triangles":165,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":17},{"id":"GO:0071222","count":14},{"id":"GO:0033327","count":14},{"id":"GO:0050728","count":14},{"id":"GO:0060068","count":14}]},{"hash":"1917777050769352939","title":"Embryonic Morphogenesis and Organ Development","description":"The terms cluster around embryonic development and organ morphogenesis across multiple tissues (pituitary, eye, hindlimb, digestive tract, lung, ureteric bud, prostate), plus broader multicellular organism development and transcriptional regulation, indicating a cohesive theme of organogenesis programs.","confidence":"High","size":29,"edges":20,"triangles":1,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":13},{"id":"GO:0000122","count":13},{"id":"GO:0048048","count":12},{"id":"GO:0007275","count":12},{"id":"GO:0060527","count":11}]},{"hash":"1075122254522183907","title":"GPCR Signaling and Neural Regulation","description":"The top GO terms point to GPCR-driven signaling cascades (adenylate cyclase activation, GPCR signaling pathways) and neural/ sensory roles (pain perception, acetylcholine metabolism, photoreceptor maintenance) with downstream effects on blood pressure and cytokine production. This suggests a cohesive cluster centered on G protein-coupled receptor signaling influencing neural, vascular, and immune processes, even though some terms are broader. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":29},{"id":"GO:0022900","count":29},{"id":"GO:0007190","count":29},{"id":"GO:0010579","count":29},{"id":"GO:0051930","count":28}]},{"hash":"1106416785880782977","title":"DNA recombination and transcription","description":"Top terms are dominated by nucleic acid\u2013related processes (DNA recombination, DNA-templated transcription, DNA integration) with some RNA modification and broader metabolism terms; the lack of edges suggests a loose grouping, but the nucleic-acid\u2013processing theme is the strongest pattern among terms.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0036265","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0090305","count":2},{"id":"GO:0015074","count":2}]},{"hash":"569473117451513495","title":"Developmental signaling and guidance","description":"The cluster centers on signaling pathways involved in development and guidance cues, including Roundabout and Smoothened pathways, and the ERK cascade, with strong signals for nervous system development and axon guidance. Additional terms span organogenesis (kidney development, ossification) and immune signaling (T cell receptor signaling, mast cell chemotaxis), suggesting a broader theme of signaling-driven cell guidance and migration across tissues. ","confidence":"Medium","size":29,"edges":239,"triangles":816,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":16},{"id":"GO:0050852","count":16},{"id":"GO:0007399","count":16},{"id":"GO:0001822","count":15},{"id":"GO:0007224","count":15}]},{"hash":"39491970003937985","title":"Bacterial fatty acid metabolism and lipoteichoic acid synthesis","description":"Dominant terms are fatty acid biosynthesis and metabolism across chain lengths, plus lipoteichoic acid biosynthesis and fatty-acyl-CoA transport, pointing to a lipid-assembly and cell envelope role typical of Gram-positive bacteria. A few outliers (nonribosomal peptide activation, bioluminescence) are less cohesive with the lipid theme.","confidence":"High","size":29,"edges":365,"triangles":2692,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006633","count":10},{"id":"GO:0070395","count":9},{"id":"GO:1902987","count":9},{"id":"GO:0043041","count":8},{"id":"GO:0036112","count":8}]},{"hash":"455080255941331372","title":"Plant glycoprotein glycosylation and cell-wall biosynthesis","description":"Many terms center on glycosylation and arabinogalactan protein metabolism, mucilage and seed coat biosynthesis, and other plant cell-wall\u2013related glycoprotein processes (AGPs, HRGPs, glycan epitopes). This points to a cohesive theme of plant glycoprotein biosynthesis and cell-wall assembly, with a few non-plant terms likely incidental. ","confidence":"High","size":29,"edges":5,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":7},{"id":"GO:0010405","count":5},{"id":"GO:0001744","count":5},{"id":"GO:0018258","count":5},{"id":"GO:0010493","count":5}]},{"hash":"926734604631511340","title":"Innate Immune Signaling and Cytokine Regulation","description":"The strongest signal in this cluster comes from TLR signaling terms (MyD88-dependent pathway, TLR2/4 signaling) and cytokine-related regulation (IL-6 production, IL-12 response), pointing to innate immune signaling and cytokine output. Additional terms like nuclear import and stress granule disassembly may relate to transcriptional control and RNA handling during immune responses, while some other terms (mitotic alignment, root development) may reflect broader cellular processes or annotation overlap. Overall, the core theme appears to be innate immune signaling and cytokine regulation.","confidence":"Medium","size":29,"edges":40,"triangles":24,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006607","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0007080","count":7},{"id":"GO:0035617","count":6},{"id":"GO:0048364","count":6}]},{"hash":"1685967951976143340","title":"Mitochondrial Translation and Ribosome Assembly","description":"Based on the top GO terms, the cluster is enriched for translation-related processes, including mitochondrial translation and ribosomal large subunit assembly, indicating a shared function in protein synthesis within mitochondria. While DNA replication and repair terms appear, the dominant signal centers on translation machinery, particularly mitochondrial translation components.","confidence":"High","size":29,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006281","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0070125","count":2},{"id":"GO:0000288","count":2}]},{"hash":"7197656737492782","title":"Embryonic development and organogenesis","description":"The GO terms cluster around vertebrate embryogenesis and organ formation, including cartilage morphogenesis, left-right patterning, placenta and trophoblast differentiation, and heart-related EMT processes. This pattern suggests proteins broadly involved in developmental patterning and organogenesis rather than a single pathway, justifying a label like embryonic development and organogenesis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060972","count":5}]},{"hash":"1205392967820227901","title":"Embryonic and placental vascular development","description":"Based on the prominent GO terms, the cluster centers on developmental processes related to the placenta and vasculature (placental branching morphogenesis, blood vessel morphogenesis, BMP signaling, and ANP-regulated blood pressure). The presence of embryonic development and vascular-related signaling supports this interpretation, while other terms such as lipid clearance and ER-to-Golgi transport likely reflect shared cellular machinery rather than a single pathway. Overall, the label \"Embryonic and placental vascular development\" best captures the dominant theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0001701","count":5},{"id":"GO:0048168","count":5},{"id":"GO:2000312","count":5},{"id":"GO:0060672","count":5}]},{"hash":"2053462731381431048","title":"Tissue development and MAPK signaling","description":"The top GO terms cluster around developmental processes across multiple tissues (heart, kidney, bone formation, myelination, megakaryocyte development, multicellular organism development) and involve signaling regulation, notably positive regulation of ERK1/ERK2 cascade and GTPase activity. This suggests a cohesive theme of tissue development coordinated by MAPK pathway signaling, justifying a name focused on both development and signaling. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0001822","count":3}]},{"hash":"873437275795903970","title":"Cardiovascular morphogenesis and cardiomyocyte differentiation","description":"This cluster is enriched for terms related to heart development, including right atrium morphogenesis, Notch signaling in heart field cardioblasts, myoblast differentiation, and venous endothelial differentiation, as well as vascular-related processes such as smooth muscle proliferation and NO signaling. The combination points to cardiovascular development with emphasis on cardiomyocyte/muscle lineages, endothelial/vascular differentiation, and associated mechanotransduction and signaling pathways.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003213","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0060843","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0003270","count":3}]},{"hash":"582958631339710808","title":"Ubiquitin-Dependent Signaling and Apoptosis (TNF/NF-\u03baB)","description":"The cluster shows strong enrichment for ubiquitin-dependent protein catabolic processes and autoubiquitination, together with TNF-mediated signaling and regulation of apoptosis, including I-kappaB/NF-\u03baB pathway components. This suggests a coherent theme around ubiquitin-driven protein turnover coordinating inflammatory signaling and cell fate decisions.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:1901253","count":13},{"id":"GO:0051865","count":13},{"id":"GO:1903762","count":13},{"id":"GO:0070535","count":12}]},{"hash":"29866712574854589","title":"Neurotransmission and brain development","description":"The dominant GO terms point to neuronal signaling and brain development, with multiple entries for serotonin, glycine, and dopamine handling, as well as thalamus development and visual learning. A lipid metabolism term (cholesterol biosynthesis) is present but compatible with neuronal membrane biogenesis. Together these terms suggest a cluster of proteins involved in neural communication and brain maturation.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":6},{"id":"GO:0008542","count":4},{"id":"GO:0006695","count":4},{"id":"GO:0015074","count":3},{"id":"GO:1905847","count":3}]},{"hash":"2127308001338003787","title":"Neural development and synapse formation","description":"The cluster\u2019s top GO terms cluster around nervous system development, brain development, myelination, and synapse assembly, with Hedgehog/Smoothened signaling and otolith morphogenesis suggesting sensory-neural development. A few immune-related terms appear, but the dominant theme centers on neural differentiation and connectivity, supporting a label focused on neural development and synapse formation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0007224","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0014068","count":4}]},{"hash":"162216695856437936","title":"Ubiquitin-dependent proteolysis and TNF signaling","description":"Most of the top GO terms cluster around ubiquitin-related processes (ubiquitin-dependent protein catabolic process, protein autoubiquitination, histone ubiquitination) and inflammatory/survival signaling (TNF-mediated signaling, regulation of apoptotic process). This points to a functional theme of ubiquitin-regulated protein turnover linked to TNF signaling rather than a single, unrelated function, justifying a label focused on ubiquitin-mediated proteolysis and associated signaling.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:1901253","count":13},{"id":"GO:0051865","count":12},{"id":"GO:1903265","count":12},{"id":"GO:1903762","count":12}]},{"hash":"1948900406061483108","title":"Embryonic development and morphogenesis","description":"Most frequent GO terms point to morphogenesis and development across diverse tissues (cartilage morphogenesis; placenta/endocrine system development; left-right pattern formation; EMT in endocardial cushion; nervous system development). This suggests a unifying theme of embryonic organogenesis and tissue differentiation, rather than a single tissue-specific function. The presence of sensory-detection terms appears ancillary. Confidence in this labeling is High.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060536","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0060806","count":7}]},{"hash":"2266074341263617954","title":"Embryonic organ and craniofacial development","description":"These 29 proteins are linked by GO terms spanning organogenesis and craniofacial patterning, including palate roof formation, cranial skeleton morphogenesis, heart and cochlea development, inner ear formation, thyroid development, and neuron migration. The mix of cardiac, neural, craniofacial, and endocrine organ development terms indicates a cohesive role in early embryonic morphogenesis across multiple tissues, rather than a single tissue function. Therefore, a label centered on embryonic organogenesis with craniofacial emphasis best captures the cluster\u2019s functional theme.","confidence":"High","size":29,"edges":52,"triangles":2,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":14},{"id":"GO:0001764","count":13},{"id":"GO:0048701","count":13},{"id":"GO:0003350","count":13},{"id":"GO:0007507","count":13}]},{"hash":"1178517517715590396","title":"Terpenoid and isoprenoid biosynthesis","description":"This cluster shows strong signals for terpenoid/isoprenoid metabolism, including geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate, monoterpene biosynthesis, cholesterol biosynthesis, and quinone biosynthesis. These recurring biosynthetic terms point to a cohesive function in isoprenoid pathway biology, with limited emphasis on the infection-structure term which may be incidental. ","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":3},{"id":"GO:0033384","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0033386","count":2},{"id":"GO:0051290","count":2}]},{"hash":"370346925185025724","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0006313","count":4},{"id":"GO:0050689","count":2},{"id":"GO:0035280","count":2}]},{"hash":"842091376456869338","title":"Tissue morphogenesis","description":"This cluster shows a common theme of developmental tissue morphogenesis, with GO terms spanning atrial septum and organ morphogenesis (heart, spinal cord, eye, lymph vessels, kidney tubule) and related transcription regulation, suggesting a broader morphogenesis function rather than a single pathway.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0003289","count":2},{"id":"GO:0048298","count":2},{"id":"GO:0003290","count":2}]},{"hash":"702326991692705690","title":"Developmental signaling and organogenesis","description":"The dominant GO terms point to development across multiple organs (heart, skeletal, kidney) plus axon guidance and key signaling pathways (ROBO, Hedgehog/Smoothened, T cell receptor signaling), suggesting a cluster of proteins involved in broad developmental signaling and organogenesis rather than a single specific process.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0001501","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0043547","count":5}]},{"hash":"1459077620010310248","title":"Transcriptional and signaling regulators","description":"These proteins cluster around regulatory roles across multiple systems: positive regulation of RNA polymerase II transcription, various signaling cascades (glucocorticoid signaling, calcineurin-NFAT), and miRNA-mediated gene silencing, with additional involvement in T cell homeostasis and developmental processes. The common thread is modulation of gene expression and signal transduction rather than a single enzymatic function, supporting a label as transcriptional and signaling regulators.","confidence":"Medium","size":29,"edges":120,"triangles":475,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:2000324","count":9},{"id":"GO:0045805","count":7},{"id":"GO:0042789","count":7},{"id":"GO:0046013","count":7},{"id":"GO:0048482","count":7}]},{"hash":"824835804101492032","title":"Retroviral genome integration and infection","description":"The top GO terms point to steps of viral infection and genome integration: DNA integration, RNA-templated DNA biosynthetic process (reverse transcription), proviral latency establishment, viral penetration into the host nucleus, and formation of infection structures. Together these indicate a retroviral life cycle and infection machinery driving genome integration and host cell invasion, with a few ancillary terms likely reflecting broader symbiont annotations. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0075713","count":6},{"id":"GO:0046718","count":6},{"id":"GO:0006310","count":6},{"id":"GO:0075015","count":5}]},{"hash":"1027530028149735960","title":"ER-Golgi trafficking and developmental signaling","description":"Enriched for secretory pathway terms (ER-to-Golgi transport, ER lumen retention, Golgi ribbon formation) and developmental signaling (Wnt secretion, axis specification, placental development), suggesting a trafficking set tied to embryonic patterning.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032525","count":4},{"id":"GO:0001893","count":4},{"id":"GO:0002121","count":4},{"id":"GO:0070863","count":4},{"id":"GO:0006888","count":4}]},{"hash":"1537731501927072356","title":"Glycinergic synaptic signaling and monoamine transport","description":"The cluster is dominated by GO terms related to glycinergic synaptic transmission, glycine import/secretion, and regulation of synaptic transmission, plus serotonin uptake and dopamine-related turnover. This points to a group of proteins involved in inhibitory glycine signaling at synapses and handling of monoamines (serotonin/dopamine), with some broader amino acid transport involvement. The combination suggests a cohesive neuronal signaling function centered on glycine-mediated synaptic activity and monoamine processing.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060012","count":5},{"id":"GO:0015820","count":5},{"id":"GO:0051918","count":4},{"id":"GO:1905847","count":4},{"id":"GO:0051610","count":4}]},{"hash":"1644823711798866821","title":"Immune and Hematopoietic Signaling","description":"The top terms cluster around immune cell signaling (B cell receptor, Fc receptor, T cell receptor regulation, interleukin-2 production) and hematopoietic lineage processes (KIT signaling, megakaryocyte development), with angiogenesis linking vascular development to hematopoiesis. A mechanosensory term appears but does not define the core theme. Together, they point to coordinated signaling in immune and blood cell development and function.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":6},{"id":"GO:0050910","count":5},{"id":"GO:0035855","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0038109","count":4}]},{"hash":"23665943705468388","title":"Retinal Neural Signaling and Excitability","description":"This cluster centers on visual perception and neural responsiveness, with terms for membrane depolarization, potassium and calcium signaling, response to electrical stimulus, and receptor internalization, all characteristic of retinal/neuronal signaling. The retinoic acid response term further supports a retinal context related to light-driven processes. Collectively, the terms suggest ion-channel\u2013mediated excitability and light-responsive signaling in retinal neurons.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0032526","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0014070","count":3},{"id":"GO:0031623","count":3}]},{"hash":"474126796802442406","title":"Vertebrate organogenesis and development","description":"The top GO terms cluster around vertebrate development and organ formation (skeletal, forebrain, cardiac morphogenesis) and ciliogenesis, with supporting cellular processes (cell division, hypoxia response, vitamin D signaling) that commonly accompany development, suggesting a developmental/organogenesis theme for this protein cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0060271","count":4},{"id":"GO:0001845","count":4},{"id":"GO:0007338","count":4}]},{"hash":"2203519391282796119","title":"Cardiac and vascular signaling","description":"The cluster\u2019s GO terms cluster around heart development, VEGF receptor signaling, sarcomere organization, and calcium ion responsiveness, all pointing to cardiac muscle function and vascular signaling. Other terms like interkinetic nuclear migration and ABA-activated signaling appear less central, suggesting some annotation noise; however, the core theme is cardiovascular muscle\u2013related signaling.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0022027","count":2},{"id":"GO:0045724","count":2},{"id":"GO:0046580","count":2}]},{"hash":"1045469203324793298","title":"Unknown","description":"The GO terms span stress responses (immobilization, cocaine, IL-1), RNA modification and ribosome-related processes (rRNA modification, tRNA wobble uridine modification, ribosomal small subunit export), metabolism (polyamine biosynthesis, obsolete sarcosine metabolic process), nodulation, and cellular senescence, with no clear shared function or pathway linking the proteins. This suggests there isn't a coherent functional theme for this cluster. ","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":13},{"id":"GO:0042220","count":12},{"id":"GO:0000154","count":11},{"id":"GO:0002098","count":11},{"id":"GO:0000056","count":11}]},{"hash":"1428478206986483708","title":"Neuroimmune signaling and pain regulation","description":"The top GO terms cluster around regulation of pain perception, cytokine production, and neurotransmitter pathways (acetylcholine, dopamine, glutamate), suggesting a theme of neural signaling modulated by immune/inflammatory signals. Some terms extend to neuroendocrine functions (blood pressure) and sensory maintenance, which fit within this broader neuroimmune regulation context.","confidence":"High","size":28,"edges":74,"triangles":66,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":27},{"id":"GO:0090198","count":27},{"id":"GO:0060408","count":27},{"id":"GO:2000484","count":27},{"id":"GO:0032651","count":27}]},{"hash":"795118550021855478","title":"Diverse Metabolic Biosynthesis and Degradation","description":"The GO terms indicate a mix of biosynthetic (antibiotic biosynthesis, biotin biosynthesis, PHB biosynthesis) and degradative/catabolic processes (beta-ketoadipate pathway, chlorophyll catabolic, triglyceride and prostaglandin catabolic, 3-phenylpropionate catabolic) along with nitrogen utilization and oxidant detoxification. This points to a cluster of proteins involved in a broad spectrum of metabolic functions rather than a single specific pathway. Therefore, a label reflecting diverse metabolic roles is appropriate.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0017000","count":10},{"id":"GO:0009102","count":10},{"id":"GO:0098869","count":8},{"id":"GO:0042952","count":8},{"id":"GO:0042619","count":7}]},{"hash":"2092163702335998110","title":"Neuronal signaling and transcriptional regulation","description":"This cluster centers on neural signaling and activity-dependent transcription: terms like excitatory postsynaptic potential and long-term memory point to synaptic plasticity, while mRNA transport and NLS-bearing nuclear import relate to activity-driven gene expression. GTPase regulation and DNA binding regulation suggest cytoskeletal trafficking and transcriptional control important for plastic changes. Amphetamine response and hypoxia signaling indicate broader cellular contexts, but the core theme appears to be neuronal signaling and transcriptional regulation.","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0043388","count":8},{"id":"GO:0001975","count":8},{"id":"GO:0006607","count":8},{"id":"GO:0071456","count":8}]},{"hash":"2267895517905996443","title":"Cell Cycle and Developmental Signaling","description":"The top GO terms are dominated by DNA replication and mitotic cell cycle, pointing to a core role in cell proliferation. The presence of terms related to axon extension, Wnt signaling, and dopamine response suggests additional involvement in developmental signaling and neural differentiation. While some immune-related terms appear, the overarching theme appears to be proliferative processes tied to development signaling, making this label a good, though not perfect, summary.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":27},{"id":"GO:0000278","count":23},{"id":"GO:0043065","count":22},{"id":"GO:0051893","count":22},{"id":"GO:0045087","count":21}]},{"hash":"1071867225169938244","title":"NF-\u03baB\u2013mediated lymphocyte homeostasis and apoptosis regulation","description":"This cluster is dominated by GO terms related to NF-\u03baB transcription factor activity and signaling, along with B and T cell homeostasis and regulation of apoptotic processes. Protein ubiquitination ties into NF-\u03baB activation, supporting a theme of immune signaling and cell survival in lymphocytes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:0001782","count":5},{"id":"GO:0046007","count":5},{"id":"GO:0043029","count":5},{"id":"GO:0016567","count":5}]},{"hash":"966660515289238700","title":"Glycan biosynthesis and glycoprotein surface components","description":"The cluster is dominated by glycosylation-related GO terms (arabinogalactan protein metabolism, O-linked glycosylation via hydroxyproline, poly-N-acetyllactosamine biosynthesis, Lewis a epitope biosynthesis), pointing to glycans and surface glycoproteins. Associated developmental terms (follicle epithelium polarity and adhesion, root hair development, seed coat mucilage) suggest that these glycan-modified surfaces influence cell surface properties and tissue organization across species, forming a cohesive glycan- and glycoprotein-centered theme.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010405","count":5},{"id":"GO:0001744","count":5},{"id":"GO:0018258","count":5},{"id":"GO:0010493","count":5},{"id":"GO:0030311","count":5}]},{"hash":"1934060243528821530","title":"Mitochondrial energy metabolism and steroid biosynthesis","description":"Most top GO terms cluster around mitochondrial metabolism: fatty acid beta-oxidation, carnitine metabolism, ubiquinone biosynthesis, and steroid biosynthesis, with leucine catabolism and thyroid hormone metabolism also highlighting mitochondrial energy handling. The presence of heart and substantia nigra development terms likely reflects tissue contexts rather than a different pathway. Overall, the core theme is mitochondria-centered energy and lipid/steroid metabolism.","confidence":"Medium","size":28,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0007507","count":3},{"id":"GO:0006694","count":3},{"id":"GO:0006552","count":3},{"id":"GO:0033540","count":3}]},{"hash":"1272503279608425275","title":"Spliceosome-mediated mRNA processing regulators","description":"The top GO terms are centered on regulation of alternative splicing via the spliceosome, general mRNA splicing via spliceosome, regulation of mRNA stability in response to stress, and other RNA-processing processes such as mRNA modification and regulatory ncRNA-mediated gene silencing. This points to a cohesive theme of post-transcriptional RNA processing control, especially spliceosome-based regulation of mRNA fate, rather than metabolic or signaling roles. Confidence: High","confidence":"","size":28,"edges":52,"triangles":0,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":4},{"id":"GO:0010610","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0048025","count":3}]},{"hash":"200666612415744374","title":"Embryogenesis and Developmental Regulators","description":"Based on the top GO terms, these proteins cluster around DNA-templated transcription and a broad set of embryonic and organ development processes (embryogenesis, heart, hindlimb, gonad, pituitary development, in utero development) along with transcriptional regulation. This pattern suggests a cohesive group of factors that coordinate transcription during embryogenesis and organogenesis, rather than a single tissue-specific function.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0060527","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0008584","count":6},{"id":"GO:0001701","count":6}]},{"hash":"1645693068084613578","title":"Translation initiation and ribosome biogenesis","description":"The top GO terms are dominated by translation initiation processes (reinitiation, preinitiation complex formation, regulation of translational initiation, IRES-dependent initiation, etc.) and ribosome biogenesis, pointing to the core machinery of protein synthesis and its regulation. Additional terms about mRNA processing and stress-responsive mRNA stability are related facets of how translation is controlled in response to cellular conditions. Taken together, the cluster seems to reflect components and regulation of translation initiation and ribosome assembly, with supporting RNA-processing context. ","confidence":"High","size":28,"edges":4,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0010610","count":7},{"id":"GO:0000398","count":7},{"id":"GO:0006378","count":6}]},{"hash":"872246029837067227","title":"Complement-Mediated ECM Signaling in Development","description":"Top GO terms indicate both complement activation (classical and alternative) and extracellular matrix-cell signaling, with angiogenesis and embryonic development terms; together they imply a protein cluster involved in immune-ECM interactions that influence vascular development and tissue organization. The presence of organ-identity maintenance and equilibrioception hints at broader developmental roles, but the dominant signal is immune-complement activity coupled with ECM signaling in developmental contexts.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0035426","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0006957","count":3}]},{"hash":"1070243918041779669","title":"Translation initiation and ribosome assembly","description":"This cluster is dominated by GO terms tied to translation initiation and ribosome assembly, including translation initiation regulation, formation of the translation preinitiation complex, and the act of translation itself, along with mRNA export from the nucleus. These collectively point to the core protein synthesis machinery as the unifying theme. Some cell-division-related terms appear, which may reflect growth-coupled regulation, and a couple of outliers (antibiotic response and lipid biosynthesis) exist but do not override the central translation-focused pattern.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046677","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0008283","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0006446","count":3}]},{"hash":"1335675259031563913","title":"Neuronal calcium signaling and phosphorylation regulation","description":"Calcium ion transport, GPCR- and cAMP-mediated signaling, and protein phosphorylation dynamics cluster around neuronal excitability and synaptic development, with some terms also touching on heart development. The core theme appears to be calcium- and phosphorylation-dependent signaling that modulates neuronal signaling and dendritic processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070588","count":4},{"id":"GO:0007205","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0010801","count":3},{"id":"GO:0043950","count":3}]},{"hash":"834465640522088903","title":"Cardiac calcium and cAMP signaling","description":"GO terms point to calcium release, GPCR/cAMP signaling, and heart-related processes (regulation of cardiac muscle contraction, heart development). Together with protein phosphorylation and GPCR-activated GTPase signaling, the cluster appears to group proteins involved in excitation-contraction coupling and adrenergic signaling in the heart. The theme is cardiac calcium handling and cAMP-mediated regulation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051281","count":11},{"id":"GO:0008284","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0043950","count":10},{"id":"GO:0007190","count":10}]},{"hash":"353233313352023028","title":"Insect Developmental Transcription and Signaling","description":"This cluster is dominated by GO terms for DNA-templated transcription and its regulation, plus antennal and photoreceptor development, and phosphorylation/STAT signaling, suggesting a module of transcriptional control linked to developmental signaling in insects. A few immune-related terms are present but appear less central, so the primary theme is developmentally oriented transcription and signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0000086","count":3}]},{"hash":"794278515351360171","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms tied to nervous system development, axon guidance, and related signaling pathways (ROBO and SHH), with supporting roles in myelination and MAPK signaling, suggesting a core function in neuronal patterning and connectivity. A couple of terms refer to other developmental processes, but the neural development theme is strongest.","confidence":"High","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035385","count":7},{"id":"GO:0001822","count":7},{"id":"GO:0007224","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0007411","count":6}]},{"hash":"506691305260163435","title":"Leukocyte adhesion and migration","description":"This cluster is enriched for immune-related functions: cellular extravasation, heterotypic cell-cell adhesion, integrin-mediated signaling, substrate-dependent cell migration, and T cell activation via TCR engagement. The combination points to leukocyte trafficking and activation, with a few peripheral terms (e.g., SA node action potential regulation) likely representing noise rather than core biology.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0045123","count":5},{"id":"GO:0034113","count":5},{"id":"GO:0035987","count":5},{"id":"GO:0002291","count":5}]},{"hash":"858731189818713929","title":"Cytoskeleton Remodeling and Cell Migration Signaling","description":"Top terms indicate actin cytoskeleton reorganization, Rho/MAPK signaling, and guidance pathways that govern cell shape and movement, spanning immune, neural, and developmental contexts. The mix of axon guidance, Roundabout signaling, polarity, and development (bone, kidney) suggests a core theme of cytoskeleton-driven migration and morphogenesis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031532","count":5},{"id":"GO:0070374","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0097350","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1980668088263010036","title":"Retina and Neural Development with Spliceosome Regulation","description":"The cluster centers on retina development and nervous system development (notably retina development in camera-type eye) and includes several GO terms linked to spliceosome-mediated mRNA splicing and its regulation, suggesting a core role in RNA processing during neural/retinal development. Translation-related terms appear too, implying a broader link to RNA metabolism, but the strongest signal remains development in neural tissues and spliceosomal control. Overall, the proteins likely function in retinal neural development with RNA splicing regulation.","confidence":"High","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0001938","count":2}]},{"hash":"924347309419085509","title":"Neural development and signaling cluster","description":"This cluster is enriched for nervous system development terms, including neurogenesis and nervous system development, as well as axon-related localization to the paranode region. It also features key signaling pathways like Roundabout (Slit-Robo) and Hedgehog (Smoothened), suggesting coordinated neuronal development and signaling. While there are some terms related to other organ developments, the neural themes are the most prominent, justifying a neural-development-centered label.","confidence":"High","size":28,"edges":354,"triangles":2710,"max_degree":27,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008284","count":10},{"id":"GO:0002175","count":9},{"id":"GO:0022008","count":9},{"id":"GO:0035385","count":9},{"id":"GO:0001822","count":9}]},{"hash":"1777987450918110601","title":"Embryonic organogenesis and placental development","description":"This cluster is driven by developmental GO terms: cartilage morphogenesis, trophoblast giant cell differentiation and placental development, endocrine system and pancreatic cell development, left\u2013right patterning, and EMT in heart cushion formation, pointing to embryogenesis and organ formation (especially placenta, heart, and cartilage). The additional ribosomal export and RNA processing terms appear as background processes rather than central themes. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0060806","count":7}]},{"hash":"1942581662112755815","title":"Developmental signaling for skeletal, muscle, and eye","description":"The top GO terms point to development-related processes (skeletal system development, lens fiber cell differentiation, multicellular organism development) and to signaling cascades (NF-kappaB, JNK, PI3K) and mechanical stimulus response, as well as myoblast differentiation. Although several terms are obsoleted, the overall pattern suggests proteins involved in developmental signaling and tissue differentiation rather than a single pathway. Thus the cluster seems to reflect broad developmental signaling programs impacting skeletal, muscle, and ocular tissues.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:0043552","count":5},{"id":"GO:0042511","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0046330","count":4}]},{"hash":"1217946346291171738","title":"Cell growth and differentiation regulation","description":"Top GO terms indicate regulation of ubiquitination, cell cycle control, adipocyte differentiation, telomere maintenance, and mechanotransduction (mechanical stimulus, muscle stretch). Together, these processes reflect a cluster of proteins that modulate cell proliferation, lineage differentiation, and responses to mechanical cues. Hence the label; moderate confidence due to the breadth of functions represented.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0045736","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0032212","count":3},{"id":"GO:2001275","count":3}]},{"hash":"1430211662919003221","title":"Pain and Temperature Sensing Signaling","description":"The cluster\u2019s top GO terms cluster around detection of mechanical and chemical stimuli related to pain, and detection of temperature in thermoception, suggesting a core theme of nociception and thermo-sensory signaling. Supporting terms point to signaling and regulation processes (GPCR signaling, GTPase activity) and some broader cellular functions (ubiquitination, mRNA processing). An outlier term related to SA node action potential hints at excitability signaling but does not negate the primary sensory signaling theme. Overall, a cohesive but somewhat broad signaling-focused nociception/thermoception cluster.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":4},{"id":"GO:0050968","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0016567","count":3},{"id":"GO:0006397","count":3}]},{"hash":"1559390579437637371","title":"Innate immune signaling and inflammation","description":"This cluster is dominated by GO terms related to innate immunity and inflammatory signaling, including NOD1 signaling, production and regulation of cytokines (IL-12, MIP-1\u03b1), macrophage-related differentiation (foam cell and follicular dendritic cell differentiation), and general pain/inflammatory responses. While a few terms touch on cell cycle or neural development, the strongest and most recurrent themes are immune sensing and inflammatory regulation, justifying a concise label focused on innate immune signaling and inflammation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":15},{"id":"GO:0010745","count":15},{"id":"GO:0051209","count":15},{"id":"GO:0007049","count":15},{"id":"GO:0045083","count":14}]},{"hash":"387351364511307977","title":"Neuronal signaling and sensory processing","description":"This cluster is dominated by GO terms tied to neural communication and sensory functions, including dopaminergic synaptic transmission, transmission of nerve impulses, sensory perception of sound, and regulation of circadian sleep/wake cycles. While there are a few outliers (acrosome reaction, amyloid-beta formation), the overall pattern supports a neural signaling/sensory processing theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0032226","count":7},{"id":"GO:0007605","count":6},{"id":"GO:0007340","count":6},{"id":"GO:0043200","count":6},{"id":"GO:1902476","count":6}]},{"hash":"866098633128053183","title":"Embryonic morphogenesis and organ development","description":"The top GO terms indicate developmental processes across several tissues: cartilage morphogenesis, heart development and left-right patterning, placental and pancreatic lineage specification, and EMT in heart structures. Together these point to embryonic tissue morphogenesis and organ differentiation as the common theme. The spliceosome term is less central but may reflect general transcriptional activity in developing cells. Therefore, this label captures the shared function of the cluster.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":11},{"id":"GO:0060707","count":11},{"id":"GO:0035270","count":11},{"id":"GO:0003323","count":11},{"id":"GO:0060806","count":11}]},{"hash":"662208255911997308","title":"Cerebellar neural development and cell-cycle signaling","description":"The cluster is enriched in cerebellar development terms (cerebellar cortex formation, Bergmann glial cell differentiation) and axon regeneration, along with insulin signaling and cell-cycle regulation terms (CDK activity, G2/M transition). This suggests proteins involved in cerebellar neural development with linked cell-cycle and metabolic signaling.","confidence":"Medium","size":27,"edges":186,"triangles":522,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048679","count":17},{"id":"GO:0021697","count":17},{"id":"GO:0050852","count":17},{"id":"GO:2001275","count":17},{"id":"GO:0008285","count":17}]},{"hash":"1460633917261798185","title":"Mesoderm Development and Myogenesis","description":"The cluster\u2019s top GO terms center on mesoderm formation, angiogenesis, and myotube differentiation, pointing to development and specialization of mesodermal tissues (muscle and vascular). Additional terms reflect growth and ECM remodeling (budding growth, metallopeptidase activity) and general signaling responses (peptide hormones, PMA, cocaine), which can interface with developmental pathways. Together, these terms suggest a coherent theme of mesodermal tissue formation and muscle/vasculature differentiation.","confidence":"Medium","size":27,"edges":308,"triangles":2052,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001707","count":27},{"id":"GO:0007118","count":27},{"id":"GO:1905050","count":27},{"id":"GO:0042220","count":27},{"id":"GO:0071375","count":27}]},{"hash":"1095089693773840584","title":"Innate immune signaling and cellular stress responses","description":"The top GO terms cluster around innate immune signaling (NOD1 pathway, regulation of IL-12, MIP-1 alpha production) and regulatory/post-translational processes (ubiquitination, PARPylation), plus general stress responses (calcium signaling, cold response, salicylic acid signaling). Some terms are less related (cardiac SA node activity, plant SA signaling), but the dominant pattern fits immune signaling and cellular stress regulation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":11},{"id":"GO:0098907","count":11},{"id":"GO:0045083","count":10},{"id":"GO:0070427","count":10},{"id":"GO:0071642","count":10}]},{"hash":"1149676472028879281","title":"Neural development and synaptic signaling","description":"This cluster is dominated by neural-related GO terms such as Schwann cell development, axonogenesis, excitatory postsynaptic potential, long-term synaptic potentiation, and visual perception, which together point to neural development and synaptic function. Some terms (e.g., mitotic cell cycle, G2/M transition) and the abscisic acid signaling term may reflect background noise or cross-kingdom annotations, but the strongest signal aligns with neural development and synaptic signaling.","confidence":"Medium","size":27,"edges":16,"triangles":3,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0014044","count":18},{"id":"GO:0060079","count":18},{"id":"GO:0000086","count":17},{"id":"GO:0009738","count":17},{"id":"GO:0000278","count":17}]},{"hash":"1294244982806327880","title":"Ubiquitin-Proteasome\u2013Mediated Degradation","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes, polyubiquitination, and SCF-dependent proteasomal degradation, indicating a core involvement in proteostasis. Additional terms on circadian rhythm regulation and cell-cycle/dna damage signaling fit with known roles of ubiquitination in timing and cell-cycle control, supporting a coherent theme around ubiquitin-mediated degradation with related regulatory functions.","confidence":"High","size":27,"edges":9,"triangles":0,"max_degree":4,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0000209","count":15},{"id":"GO:0031146","count":14},{"id":"GO:0042752","count":12},{"id":"GO:0031571","count":12}]},{"hash":"1569110989696138233","title":"Immune signaling and transcriptional regulation cluster","description":"Top terms indicate a core of DNA-templated transcription linked to immune signaling (T cell receptor signaling, chemotaxis, LPS and GM-CSF responses). This suggests proteins involved in transcriptional regulation during immune activation and signal transduction; while other terms point to broader cellular processes, the dominant pattern is immune signaling coupling with transcriptional control.","confidence":"Medium","size":27,"edges":147,"triangles":291,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":21},{"id":"GO:0006935","count":17},{"id":"GO:0050852","count":16},{"id":"GO:0071222","count":16},{"id":"GO:0097011","count":16}]},{"hash":"1064151250027616202","title":"GPCR-cAMP-ERK signaling in neural and vascular systems","description":"The top terms point to GPCR-driven signaling that activates adenylate cyclase and the ERK cascade, with prostaglandin response and effects on neural functions (dopaminergic transmission, visual learning) as well as vascular/immune outcomes (blood pressure regulation, macrophage chemotaxis). The electron transport chain term seems ancillary, so the core theme is GPCR-mediated signaling and downstream pathways across neural, vascular, and immune contexts.","confidence":"Medium","size":27,"edges":6,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0007190","count":21},{"id":"GO:0010579","count":21},{"id":"GO:0071380","count":21}]},{"hash":"1042768212804207711","title":"Embryonic morphogenesis and angiogenesis","description":"The cluster is dominated by developmental processes such as embryonic cranial skeleton morphogenesis, mesoderm formation, and angiogenesis, with supporting signals like peptide hormone response and metallopeptidase activity for tissue remodeling. While DNA replication and kinetochore localization hint at cell proliferation, the overarching theme is embryonic tissue morphogenesis and vascular formation. ","confidence":"High","size":27,"edges":195,"triangles":621,"max_degree":23,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":25},{"id":"GO:0034501","count":25},{"id":"GO:0045736","count":25},{"id":"GO:0006260","count":25},{"id":"GO:0001707","count":24}]},{"hash":"1914045618686844461","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent catabolism, autoubiquitination, various ubiquitin linkages) alongside innate immune and antiviral defense terms (NF-kappaB, TNF signaling). This suggests proteins coordinating ubiquitin-mediated regulation of innate immune responses and antiviral defense.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0045087","count":12},{"id":"GO:0051607","count":12},{"id":"GO:0051865","count":10},{"id":"GO:0070534","count":10}]},{"hash":"1200195625526881439","title":"Neural development and sensory signaling","description":"The top GO terms point to neural and sensory themes, with Schwann cell development and visual perception suggesting neural/sensory functions, plus regulatory signaling processes (GTPase activity, kinase regulation) and vascular branching that can accompany neural tissue development. Some terms (DNA replication, ERAD) are less cohesive with the core theme, likely reflecting broader cellular housekeeping or annotation noise, but the central pattern centers on neural development and sensory signaling.","confidence":"Medium","size":27,"edges":34,"triangles":0,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0006986","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1116208537876803186","title":"Regulated vesicle signaling in immune and vascular contexts","description":"The top GO terms point to vesicle-related processes (synaptic vesicle priming, acrosome reaction, neutrophil degranulation) and to regulation of signaling pathways (Ras, Rho) alongside immune and vascular responses (IL-4 production, B cell affinity maturation, VEGF stimulus). Together they describe coordinated control of vesicle exocytosis and signaling across immune, vascular, and reproductive contexts, supporting this label.","confidence":"Medium","size":27,"edges":300,"triangles":2037,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":3},{"id":"GO:0016082","count":3},{"id":"GO:0043314","count":3},{"id":"GO:0007340","count":3},{"id":"GO:0060313","count":3}]},{"hash":"1404578514481154943","title":"Central Metabolism and Biosynthesis","description":"The cluster prominently features core metabolic processes (glycolysis, TCA cycle, 2-oxoglutarate metabolism) alongside biosynthetic pathways (lysine, biotin, protoporphyrinogen IX) and even antibiotic biosynthesis, suggesting a cohesive group tied to energy production and biosynthesis rather than a single precise function.","confidence":"Medium","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":11},{"id":"GO:0019878","count":9},{"id":"GO:0006099","count":8},{"id":"GO:0033512","count":8},{"id":"GO:0006096","count":7}]},{"hash":"1804859914566133571","title":"Neural development and synaptic signaling","description":"The cluster centers on neural development and synaptic signaling, with strong signals for NMDA receptor regulation, regulation of excitatory postsynaptic potential, neuroblast differentiation, retina development, and cytoskeletal organization at the active zone, plus related metabolic (choline, amyloid precursor protein processing) and xenobiotic response processes that support neuronal function.","confidence":"High","size":27,"edges":346,"triangles":2805,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000310","count":13},{"id":"GO:0002087","count":13},{"id":"GO:0060041","count":13},{"id":"GO:0002076","count":13},{"id":"GO:0042493","count":12}]},{"hash":"2223701494655431091","title":"DNA metabolism and oxidative stress response","description":"The top GO terms cluster around DNA metabolism (integration, recombination, catabolic processes) alongside oxidative stress and redox signaling (response to hydrogen peroxide, redox homeostasis) and cellular outcomes like apoptosis, with additional signaling-related terms. This suggests proteins participating in DNA processing coupled with stress-induced signaling, warranting the label \"DNA metabolism and oxidative stress response.\"","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0006310","count":7},{"id":"GO:0070301","count":4},{"id":"GO:0006308","count":4},{"id":"GO:0045454","count":4}]},{"hash":"1404500101197320976","title":"Intracellular trafficking and gene expression","description":"The cluster shows strong signals for vesicle transport between the ER and Golgi (anterograde and retrograde), indicating a focus on the secretory pathway. In addition, frequent terms for transcription, RNA capping, ribosome biogenesis, and TORC1 signaling point to core gene expression and protein synthesis machinery. Taken together, these proteins seem to represent fundamental cellular logistics and expression control rather than a single specialized pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0036265","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0006351","count":4}]},{"hash":"1936557852334822100","title":"Transmembrane Transport of Sugars, Ions, and Neurotransmitters","description":"This cluster centers on GO terms for transport across membranes with substrates including vitamins, sugars (galactose, fucose), sialic acid, nitrate/nitrite, sodium ions, xenobiotics, and neurotransmitter loading into vesicles, indicating a membrane transport function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3}]},{"hash":"22049662902391258","title":"Dendritic Cell\u2013Driven Innate Immune Signaling","description":"The GO terms center on innate immunity and dendritic cell functions (innate immune response, defense against bacteria, dendritic cell cytokine production, Fc receptor signaling, and T cell proliferation regulation), suggesting a cluster focused on DC-mediated immune activation and myeloid lineage signaling. Some terms like angiogenesis and embryonic morphogenesis may be peripheral or context-dependent, but the core theme is dendritic-cell\u2013driven innate immune signaling.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0042742","count":3},{"id":"GO:0097326","count":3},{"id":"GO:0002371","count":3},{"id":"GO:0046007","count":3}]},{"hash":"1213733293342663583","title":"Thermoregulation and ion transport","description":"This cluster is dominated by temperature-related GO terms (diet-induced thermogenesis, cellular response to temperature stimulus, thermoreception, cold response) and membrane ion transport (K+, Na+, Mn), implying proteins involved in sensing/regulating temperature with associated ion flux.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0097623","count":7},{"id":"GO:0098719","count":7}]},{"hash":"92182068947504673","title":"Developmental Cytoskeletal Signaling","description":"The top GO terms point to regulation of GTPase activity and actin crosslinking/assembly, which together imply cytoskeletal regulation and signaling. Several development-related terms (heart development, cartilage morphogenesis, trophoblast differentiation, insulin secretion in response to glucose) suggest tissue-specific roles during development, but the common thread across terms is signaling that modulates the cytoskeleton in a developmental context. Because the cluster appears to center on cytoskeletal dynamics linked to developmental processes rather than a single tissue or function, this label captures the shared theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0007601","count":5},{"id":"GO:0022400","count":4},{"id":"GO:0051764","count":4},{"id":"GO:0007507","count":4}]},{"hash":"1847111680992946093","title":"Ciliary and flagellar microtubule dynamics","description":"GO terms point to cilium/flagellum movement and microtubule regulation, including epithelial cilium movement, flagellated sperm motility, regulation of axon extension, and microtubule severing, along with tubulin post-translational modifications (polyglycylation, polyglutamylation). While some terms touch broader processes like heart development and inflammatory response, the core signals indicate ciliogenesis and motile ciliary function. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050728","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0050796","count":2},{"id":"GO:0045454","count":2},{"id":"GO:1905419","count":2}]},{"hash":"1094824246328466778","title":"Actin dynamics and axon guidance in development","description":"This cluster centers on actin cytoskeleton remodeling (actin nucleation) and membrane dynamics, with explicit links to axon guidance and broader multicellular development. The inclusion of calcium signaling regulation and phosphorylation-related pathways indicates coordinated signaling during development and neural wiring, aligning the structural and signaling roles with developmental processes.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903526","count":4},{"id":"GO:0045010","count":4},{"id":"GO:0043517","count":3},{"id":"GO:0048875","count":3},{"id":"GO:0007396","count":3}]},{"hash":"884437780111511578","title":"Neuroimmune Adhesion and Synapse Assembly","description":"The cluster centers on neuronal synapse formation/organization (synapse assembly, organization, inhibitory postsynaptic potential) combined with innate immune signals (complement activation, innate immune response) and cell\u2013cell adhesion, suggesting a cohesive role in neuroimmune interactions at synapses; a few terms like kidney development and smooth muscle proliferation may reflect broader tissue contexts but do not override the core neural\u2013immune theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0007157","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0030913","count":7}]},{"hash":"668739744536907234","title":"Axon Guidance and Neural Crest Development","description":"The cluster is dominated by GO terms tied to neuron projection guidance, axonal fasciculation, synapse assembly, and cranial nerve organization, including sympathetic neuron projection guidance, trigeminal nerve structure, branchiomotor neuron axon guidance, and semaphorin-plexin signaling; neural crest migration and crest-derived skeletal contributors reflect broader neural crest\u2013driven development. ","confidence":"High","size":27,"edges":15,"triangles":1,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":8},{"id":"GO:0097491","count":7},{"id":"GO:0097490","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0007413","count":7}]},{"hash":"703494379168487896","title":"DNA Transcription Regulators and NF-kB Modulators","description":"The top GO terms point to regulation of DNA-templated transcription and negative regulation of canonical NF-kappaB signaling, suggesting a core theme of transcriptional control with NF-kB pathway modulation. Additional terms like neutrophil clearance, collagen fibril organization, and endocrine pancreas development likely reflect multifunctional or broadly annotated proteins, or noise, rather than a single cohesive complex. The lack of network edges further supports a set of regulatory proteins rather than a tightly connected complex, making this a reasonable, if imperfect, core function label.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0097350","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0031018","count":2},{"id":"GO:0000733","count":2}]},{"hash":"2150966438519794047","title":"Neuro-immune signaling regulators","description":"This set is enriched for diverse signaling responses to pathogens (fungal origin, LPS), inflammatory cytokine regulation (IL-3 and GM-CSF production), growth factor signaling (PDGF receptor pathway), and calcium signaling (store-operated calcium channel activation), with a note of neural development (forebrain). The common thread is regulatory signaling proteins that modulate multiple pathways across immune and neural contexts, rather than a single canonical function.","confidence":"Medium","size":27,"edges":36,"triangles":13,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071226","count":26},{"id":"GO:0010641","count":22},{"id":"GO:0030900","count":22},{"id":"GO:0032355","count":22},{"id":"GO:0032496","count":22}]},{"hash":"370126611100970441","title":"Ubiquitin-Dependent Proteolysis and TNF-JNK Signaling","description":"This cluster is dominated by ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process, ubiquitination, autoubiquitination) indicating a core role in targeted protein degradation. Additional terms point to chromatin regulation (histone catabolic process, histone modification) and dosage compensation, which can be linked to ubiquitin pathways and chromatin remodeling. The presence of innate immune response and TNF/JNK signaling terms suggests these proteins influence inflammatory signaling networks, potentially through controlled turnover of signaling adapters or histone modifiers. Overall, the terms converge on a theme of ubiquitin-driven regulation of protein stability intersecting immune signaling.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":21},{"id":"GO:0085020","count":13},{"id":"GO:1903265","count":13},{"id":"GO:0036205","count":13},{"id":"GO:0051865","count":13}]},{"hash":"273530085507378693","title":"Unknown","description":"The GO terms span diverse developmental processes (embryo, nervous system, hematopoietic lineages, pituitary) and other unrelated functions (lipopolysaccharide response, apoptosis, transcription regulation, fertilization) with no single cohesive function connecting all proteins, so a confident, specific label cannot be assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0090009","count":6},{"id":"GO:0048935","count":6},{"id":"GO:0006915","count":6},{"id":"GO:0030901","count":6}]},{"hash":"1429345826299246639","title":"RNA processing and translation machinery","description":"The top GO terms show strong enrichment for mRNA splicing via spliceosome, translation reinitiation, translation preinitiation complex formation, and ribosome biogenesis, indicating a cohesive cluster of proteins involved in RNA processing and assembly of the protein synthesis machinery. Other terms like cell division and protein homooligomerization are present but appear secondary to the core gene expression functions.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":9},{"id":"GO:0002188","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0007369","count":7},{"id":"GO:0042254","count":7}]},{"hash":"1929785407479210078","title":"Platelet Activation and Coagulation","description":"The cluster centers on Ca2+ signaling linked to ER/mitochondrial calcium regulation, which is key for platelet activation, granule excretion, and adhesion. The presence of isopeptide cross-linking (transglutaminase activity) and explicit coagulation terms like fibrin clot formation strongly tie the proteins to clot stabilization and blood coagulation, with excretion reflecting platelet granule release. A few terms (e.g., hemoglobin metabolism, obsolete regulation terms) are less directly connected, but the dominant theme clearly points to platelet-mediated coagulation. ","confidence":"High","size":27,"edges":19,"triangles":3,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0032471","count":3},{"id":"GO:0051561","count":3},{"id":"GO:0007155","count":2},{"id":"GO:0007588","count":2},{"id":"GO:1903070","count":2}]},{"hash":"1647335104418470599","title":"Neural and Cardiac Development Linked to Calcium Signaling","description":"The top GO terms cluster around calcium signaling (positive regulation of voltage-gated calcium channels, excitatory postsynaptic potential) together with neural and cardiac development (Schwann cell development, heart development, angiogenesis) and general cell-cycle/phosphorylation activities, suggesting a theme of calcium-mediated development in neural and cardiovascular contexts. An outlier plant ABA term and general mitotic terms exist but do not override the central calcium-development link.","confidence":"Medium","size":27,"edges":24,"triangles":4,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1901387","count":9},{"id":"GO:0097274","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0014044","count":7},{"id":"GO:0000086","count":7}]},{"hash":"1918023661502857096","title":"Protein quality control and membrane trafficking","description":"This cluster is enriched for processes related to protein quality control and degradation (ubiquitin-dependent ERAD; aggrephagy) and trafficking regulation (negative regulation of GPCR endocytosis, clathrin-dependent endocytosis). Together these suggest a theme of maintaining proteostasis and coordinating receptor trafficking. Some items (spindle pole body duplication, nucleotide-excision repair) appear less connected and may reflect multi-function proteins or annotation noise.","confidence":"Medium","size":27,"edges":27,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0007253","count":4},{"id":"GO:1904021","count":3},{"id":"GO:0035973","count":3},{"id":"GO:0030474","count":3}]},{"hash":"768855373763673022","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0001403","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0032933","count":6},{"id":"GO:0006890","count":6}]},{"hash":"2169505400846355028","title":"Developmental MAPK/Ras signaling and cytoskeletal remodeling","description":"The top terms converge on regulation of ERK/MAPK, Rho, and Ras signaling, along with actin-based movement, cell adhesion, and development, suggesting a coherent role in developmental signaling that coordinates cytoskeletal dynamics and tissue organization.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0046580","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0001759","count":2}]},{"hash":"2244550071668948159","title":"Neural Thermosensation and Dopaminergic Signaling","description":"The cluster is enriched for temperature- and pain-related terms (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis) alongside neural signaling (synaptic transmission, dopaminergic; visual learning), with ion homeostasis terms suggesting neuronal excitability; together this points to proteins involved in brain thermosensory pathways and dopamine-mediated neural signaling.","confidence":"High","size":26,"edges":97,"triangles":121,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0002024","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0030007","count":9},{"id":"GO:0097623","count":9}]},{"hash":"1776555309689822238","title":"Diverse biosynthesis and RNA modification","description":"Top terms show multiple biosynthetic processes (antibiotic, biotin, menaquinone, polyamine) and RNA processing/modification (rRNA modification, tRNA wobble uridine modification, ribosomal subunit export). This suggests a cluster enriched for metabolic biosynthesis with ancillary RNA-related functions, rather than a single narrow role.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0009102","count":6},{"id":"GO:0042220","count":5},{"id":"GO:0035690","count":5},{"id":"GO:0009234","count":5}]},{"hash":"1535530292324511095","title":"Negative regulators of signaling pathways","description":"This cluster is enriched for GO terms describing negative regulation across multiple signaling cascades, including T cell receptor signaling, ERK/MAPK cascade, PI3K/AKT signaling, and focal adhesion, along with related processes in synaptic organization. The prominence of negative regulatory terms and a dephosphorylation activity term suggests these proteins function broadly as inhibitors of signaling rather than a single pathway, possibly with roles in immune and neuronal contexts.","confidence":"High","size":26,"edges":315,"triangles":2381,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":21},{"id":"GO:0070373","count":21},{"id":"GO:0000200","count":21},{"id":"GO:0035335","count":18},{"id":"GO:0097107","count":17}]},{"hash":"1544196994356122594","title":"Embryonic development and organogenesis","description":"The cluster's top GO terms center on developmental processes and tissue patterning (heart, retina, palate) and neural guidance, with regulation of cell migration and transcription. This suggests proteins that coordinate embryonic organogenesis and neuronal development. Some terms (antibiotic biosynthetic process, oxidation-reduction) are less central or potentially cross-domain annotations, but the dominant theme is developmental regulation and organ formation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030334","count":4},{"id":"GO:0006355","count":4},{"id":"GO:0046627","count":4},{"id":"GO:0030194","count":4},{"id":"GO:0017000","count":3}]},{"hash":"971498428807987914","title":"Nuclear import and chromosomal cohesion/segregation","description":"The cluster centers on nuclear import (NLS-bearing protein import, ribosomal protein import into nucleus, nuclear pore complex assembly) and chromosomal maintenance (meiotic sister chromatid cohesion, mitotic sister chromatid separation, chromatin assembly during DNA replication). Desumoylation regulation and GTPase activity further support coordinated nuclear transport and chromatin regulation. Together, these terms indicate a module tied to nuclear transport and chromosome maintenance during cell division.","confidence":"High","size":26,"edges":3,"triangles":1,"max_degree":2,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0051754","count":8},{"id":"GO:0060188","count":7},{"id":"GO:2001241","count":7},{"id":"GO:0000060","count":7},{"id":"GO:0051292","count":7}]},{"hash":"1547486416799950398","title":"Neurotransmission and sensory regulation","description":"Top GO terms cluster around neuronal signaling and sensory processes: GPCR-activating signaling, acetylcholine and dopamine receptor regulation, pain perception, and photoreceptor maintenance point to coordinated control of neurotransmission and sensory function. Immune-related terms are present but appear secondary, while electron transport chain hints at energy support for signaling. Overall, the dominant theme is neural signaling and sensory regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":23},{"id":"GO:0022900","count":23},{"id":"GO:0010579","count":23},{"id":"GO:0051930","count":22},{"id":"GO:0090198","count":22}]},{"hash":"341226312000706269","title":"Unknown","description":"The top GO terms include DNA replication, DNA recombination, and DNA integration, suggesting a possible core in DNA metabolism, but this is contradicted by several glycosylation and development-related terms (arabinogalactan protein metabolism, Lewis A epitope biosynthesis, insect visual primordium formation, follicle cell adhesion). The diverse functions across nuclear processes, glycan biosynthesis, and insect development do not reveal a single coherent theme, so a concise, representative label cannot be determined.","confidence":"","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0006260","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0010405","count":3}]},{"hash":"2228689372898879734","title":"Ribosome biogenesis and nuclear import","description":"The cluster is dominated by GO terms related to ribosome biogenesis (including large subunit biogenesis) and nuclear import of ribosomal proteins, along with nuclear pore complex assembly and NLS-bearing protein import, which together point to coordinated ribosome assembly functions in the nucleus and transport to the cytoplasm. Translation and cell division terms also align with ribosome production and nucleocytoplasmic trafficking. ","confidence":"High","size":26,"edges":321,"triangles":2508,"max_degree":25,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0042273","count":4},{"id":"GO:0051292","count":4},{"id":"GO:0006610","count":4},{"id":"GO:0006607","count":4}]},{"hash":"39506612041846303","title":"Arabinogalactan protein glycosylation and mucilage biosynthesis","description":"Based on prevalent GO terms such as arabinogalactan protein metabolic process, O-linked glycosylation via hydroxyproline, Lewis a epitope biosynthesis, poly-N-acetyllactosamine biosynthetic process, and seed coat mucilage biosynthesis, the cluster appears enriched for plant cell wall glycoproteins\u2014especially arabinogalactan proteins\u2014and their complex O-glycosylation. Root hair development and mucilage-related terms further support a plant-developmental context linked to AGP-modified glycans. A couple of insect-related terms likely reflect cross-species annotations, but the dominant signal is AGP glycosylation and mucilage biosynthesis in plants.","confidence":"High","size":26,"edges":66,"triangles":64,"max_degree":14,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0010405","count":7},{"id":"GO:0001744","count":7},{"id":"GO:0018258","count":7},{"id":"GO:0010493","count":7},{"id":"GO:0030311","count":7}]},{"hash":"908999256254563797","title":"Actin-mediated cell migration and polarity","description":"The top GO terms point to actin cytoskeleton dynamics (actin bundle assembly, barbed-end capping) and signaling that governs cell movement and epithelial polarity (Rho GTPase regulation, TGF-beta response, and related pathways). A secondary note is the presence of B cell receptor signaling, which may reflect shared signaling components rather than a primary function of the cluster. Overall, the proteins appear to cluster around actin-driven motility and polarity establishment.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016477","count":5},{"id":"GO:0090162","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0050853","count":4}]},{"hash":"561571170333180494","title":"Nutrient and xenobiotic membrane transporters","description":"The cluster is dominated by transmembrane transport GO terms across diverse substrates: vitamin transmembrane transport, xenobiotic transmembrane transport, L-ascorbic acid metabolism, glucose and ion transport (sodium, phosphate), and even specific substrates like 4-hydroxyphenylacetate. This points to a cohesive set of membrane transporter proteins involved in uptake and efflux of nutrients and xenobiotics, potentially linked to gut epithelial function. ","confidence":"High","size":26,"edges":176,"triangles":464,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":25},{"id":"GO:0006855","count":25},{"id":"GO:0042891","count":24},{"id":"GO:0019852","count":23},{"id":"GO:0042908","count":23}]},{"hash":"1719184583434118380","title":"Neural and vascular development with ER stress response","description":"These proteins show strong ties to neural development (substantia nigra development, axon guidance) and vascular processes (sprouting angiogenesis regulation, anatomical structure arrangement), indicating a developmental role. The presence of ER stress response and CAMKK-AMPK signaling terms suggests links to metabolic regulation during development, while trafficking-related terms (Cvt pathway, vacuole fusion) point to intracellular transport involvement. Confidence: Medium","confidence":"","size":26,"edges":126,"triangles":336,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":15},{"id":"GO:0021762","count":13},{"id":"GO:1903206","count":11},{"id":"GO:0034976","count":11},{"id":"GO:0032258","count":11}]},{"hash":"207769169761822703","title":"Spliceosome-Mediated mRNA Processing","description":"GO term analysis shows strong enrichment for spliceosome-driven splicing and mRNA processing (including regulation of splicing, alternative splicing, and mRNA modification), with additional signals for mRNA stability under stress and translation-related processes. This pattern suggests the cluster represents proteins involved in RNA processing and spliceosome-mediated regulation of mRNA fate. ","confidence":"High","size":26,"edges":100,"triangles":251,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":13},{"id":"GO:0010610","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0002188","count":10},{"id":"GO:0045292","count":10}]},{"hash":"641434207835097342","title":"Mitotic cell cycle and development","description":"The top terms cluster around mitosis, cell division, and organismal growth/development (mitotic cell cycle, cell division, multicellular organism development), with APC/C-dependent processes guiding chromosome segregation. A few outlier terms relate to actin regulation and stress responses, but the dominant theme is cell-division\u2013linked growth in multicellular contexts.","confidence":"High","size":26,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":10},{"id":"GO:0035264","count":9},{"id":"GO:0034316","count":9},{"id":"GO:0051301","count":9},{"id":"GO:0007275","count":9}]},{"hash":"1518429375238046000","title":"Olfactory signaling and memory","description":"The cluster is enriched for neural and sensory terms such as sodium and potassium ion transport, receptor clustering, olfactory learning, regulation of sensory perception of pain, medium-term memory, and forward locomotion, pointing to olfactory processing and related neuronal signaling. Some terms like methanol catabolic process and peptidoglycan metabolic process appear unrelated and may be artifacts, but the dominant theme centers on smell-related signaling and memory processes.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0043113","count":6},{"id":"GO:0060134","count":6},{"id":"GO:0008355","count":6}]},{"hash":"311434670208433170","title":"Ubiquitin-Proteasome-Mediated Degradation","description":"This cluster is strongly characterized by ubiquitination-related GO terms (ubiquitin-dependent protein catabolic processes, SCF-dependent proteasomal degradation, polyubiquitination, autoubiquitination) and emphasizes proteasome-mediated protein turnover. Additional terms on circadian rhythm regulation, histone ubiquitination, and immune signaling (TNF) reflect broader roles of ubiquitination in clock control, chromatin dynamics, and inflammatory pathways, suggesting a cohesive theme around the ubiquitin-proteasome system. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0042752","count":11},{"id":"GO:0031146","count":11},{"id":"GO:0000209","count":10},{"id":"GO:0051865","count":9}]},{"hash":"1862598947587857034","title":"Neuronal development and synaptic signaling","description":"Top GO terms cluster nervous system development, excitatory synaptic transmission, and regulation of synaptic vesicle cycling/ERK signaling, suggesting a neural development and synaptic function theme; occasional bone ossification and mitotic cycle terms are outliers.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0043931","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0021762","count":6}]},{"hash":"1934051118519732788","title":"Oogenesis and meiotic cell division","description":"The top terms cluster around DNA-templated transcription, DNA integration, mitotic chromosome condensation, and female meiotic division, with specific emphasis on oocyte localization and germarium-derived egg chamber formation, suggesting an oogenesis- and meiosis-driven cell-cycle program, complemented by TORC1 signaling and GTPase activity regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0070262","count":2},{"id":"GO:0007143","count":2},{"id":"GO:0038202","count":2}]},{"hash":"1458360789633577314","title":"Auditory synapse development and plasticity","description":"The top GO terms point to auditory-related functions and synaptic remodeling, including sensory perception of sound, vocalization behavior, dendritic spine morphogenesis, regulation of Rho signaling, and long-term synaptic depression, all of which together suggest maturation and plasticity of excitatory synapses in auditory pathways. Heart development appears less connected and does not define the cluster's primary theme. ","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0051835","count":6},{"id":"GO:0071625","count":6},{"id":"GO:0060997","count":6}]},{"hash":"1481864729835710181","title":"Developmental Signaling and Differentiation Regulators","description":"The cluster is enriched for terms spanning key signaling pathways (Wnt, Hippo), differentiation processes (keratinocyte differentiation, dendrite morphogenesis), and regulation of cell fate (apoptotic processes, transcription), suggesting proteins that broadly modulate signaling cascades to control development, differentiation, and survival rather than a single pathway.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090263","count":18},{"id":"GO:0030216","count":17},{"id":"GO:0060044","count":17},{"id":"GO:0035329","count":17},{"id":"GO:0006915","count":17}]},{"hash":"50116459601496199","title":"Immunometabolic Signaling and Transcription Machinery","description":"The cluster shows both immunometabolic signals (cellular response to lipopolysaccharide, prostaglandin biosynthesis, retinoic acid response, brown fat differentiation) and core transcription/translation processes (RNA polymerase\u2013dependent transcription, ribosome biogenesis, tRNA transcription). There isn't a single cohesive pathway linking all terms, suggesting a mix of immune/metabolic signaling with fundamental gene expression machinery; hence the label reflects this dual nature. Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0050873","count":2},{"id":"GO:0070207","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0032526","count":2}]},{"hash":"1524159578635866188","title":"Neuronal cytoskeleton remodeling and spine maintenance","description":"The top GO terms cluster around regulation of Rho GTPase signaling and actin dynamics (Arp2/3), dendritic spine maintenance, and synaptic plasticity, with protein localization to axonal domains (paranodes/juxtaparanodes). This suggests coordinated cytoskeletal remodeling that supports spine structure and neuronal compartment organization.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0070830","count":3}]},{"hash":"1482957469892946544","title":"Anthocyanin and flavonoid biosynthesis","description":"The top GO terms are dominated by anthocyanin-containing compound biosynthesis and related flavonoid biosynthetic processes (e.g., cyanidin 3-O-glucoside and quercetin O-glucoside biosynthesis), with supporting oxidation-reduction and glycosylation/conjugation steps. This pattern points to proteins involved in plant secondary metabolism producing flavonoids and their derivatives, making the flavonoid/anthocyanin biosynthesis theme most representative of the cluster, despite a few outlier annotations.","confidence":"High","size":26,"edges":11,"triangles":5,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0009718","count":5},{"id":"GO:0033485","count":4},{"id":"GO:0052697","count":4},{"id":"GO:0030259","count":4}]},{"hash":"2261198869670367934","title":"Cardiac and Skeletal Muscle Contraction and Regulation","description":"The terms point to muscle function across cardiac and skeletal tissues, including contraction, filament sliding, ventricular morphogenesis, and fiber-type regulation, indicating a coherent cluster centered on muscle contraction mechanisms and their regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014883","count":2},{"id":"GO:0055010","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0032972","count":2},{"id":"GO:0043057","count":1}]},{"hash":"2192544502317151096","title":"Placental and Embryonic Development","description":"The top GO terms cluster around placental-related differentiation (trophoblast giant cells, placenta development), embryonic endocrine and organ morphogenesis (endocrine pancreas, cartilage morphogenesis, left-right patterning), and EMT events in heart formation, pointing to a shared role in early development and tissue morphogenesis. A couple of general processes (splicing, ubiquitination) are present but do not override the developmental theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":11},{"id":"GO:0060536","count":10},{"id":"GO:0035270","count":10},{"id":"GO:0003323","count":10},{"id":"GO:0060806","count":10}]},{"hash":"1931783052989905464","title":"Embryonic Development and Organ Morphogenesis","description":"The top GO terms cluster around developmental processes and tissue formation: cartilage morphogenesis, trophoblast/placental differentiation, endocrine system development, pancreatic cell development, and left-right pattern formation, suggesting a theme of embryonic development and organogenesis. Some terms on signaling (NF-kappaB/ERK) may reflect regulation of these developmental pathways or broader cellular signaling contexts.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0031663","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1245538667627278580","title":"Developmental differentiation signaling across tissues","description":"Top terms show involvement in skeletal system development, osteoblast and lens fiber cell differentiation, and neuron projection development, with ERK signaling regulation suggesting a common developmental signaling role. The mix of adhesion and immune-related terms hints at broader remodeling during development. Overall, the cluster appears to represent proteins participating in developmental differentiation across multiple tissues rather than a single specialized function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0070306","count":3},{"id":"GO:2001241","count":2},{"id":"GO:0001845","count":2}]},{"hash":"192867283280050625","title":"Amino acid biosynthesis and glutathione detox pathways","description":"The cluster\u2019s GO terms center on amino acid metabolism (threonine biosynthesis, methionine salvage) and redox/detox pathways (phytochelatin biosynthesis, glutathione transport), suggesting a shared theme of metabolic processing coupled with detoxification. Some terms like phosphorylation, transcription, and antibiotic response are broader regulatory processes that appear ancillary to the main metabolic theme.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019284","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0009088","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1590863604278761288","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":104,"triangles":115,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0042853","count":5},{"id":"GO:0006633","count":5},{"id":"GO:0009437","count":4},{"id":"GO:0019518","count":4}]},{"hash":"2260324351183544506","title":"Thermoregulation and potassium homeostasis","description":"The cluster is dominated by GO terms linking temperature response and thermogenesis (diet-induced thermogenesis, cellular response to temperature stimulus) with potassium handling (export/import across membrane, intracellular potassium homeostasis, membrane potential stabilization). This points to a cohesive theme where temperature-regulated processes are coupled to ionic balance and membrane potential maintenance. Peripheral terms on skin development and multicellular development are present but do not override the core temperature\u2013ion regulation signal.","confidence":"Medium","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0030322","count":12},{"id":"GO:0097623","count":12}]},{"hash":"478120125901178930","title":"Neural development and synaptic signaling","description":"Most of the top GO terms cluster around neural development and synaptic function (axonogenesis; Schwann cell development; excitatory postsynaptic potential; long-term synaptic potentiation). There are also broad development and cell-cycle terms suggesting proliferative contexts, but the dominant theme is neural differentiation and synaptic maturation, making this label representative. ","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":25},{"id":"GO:0009738","count":25},{"id":"GO:0000278","count":25},{"id":"GO:0010800","count":25},{"id":"GO:0007409","count":25}]},{"hash":"1880564514721104215","title":"Retroviral life cycle: integration, latency, and reverse transcription","description":"This cluster is dominated by GO terms tied to retroviral biology: DNA integration, DNA replication, DNA recombination, RNA-templated DNA biosynthesis (reverse transcription), and establishment of integrated proviral latency, plus steps like viral entry into the host nucleus. A few terms reference host\u2013symbiont interactions and RNAi suppression, which align with viral strategies to access the genome and evade host defenses. Taken together, the terms point to a cohesive retroviral life cycle signature rather than generic DNA replication.","confidence":"High","size":25,"edges":134,"triangles":303,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":11},{"id":"GO:0006260","count":9},{"id":"GO:0006310","count":9},{"id":"GO:0075713","count":7},{"id":"GO:0039651","count":7}]},{"hash":"1559831955116116520","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":20,"triangles":21,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0016973","count":8},{"id":"GO:0000398","count":6},{"id":"GO:0006369","count":5},{"id":"GO:0035640","count":5},{"id":"GO:0071035","count":5}]},{"hash":"1160550572816548952","title":"Embryonic Development and Organogenesis","description":"The GO terms point to developmental processes across multiple tissues and organs during embryogenesis: cartilage morphogenesis, placental/trophoblast differentiation, endocrine system and pancreatic development, left-right pattern formation, EMT in heart development, and fertilization. While some terms are broader (receptor internalization, locomotory behavior), the dominant theme is embryo- and organ-formation and differentiation, suggesting these proteins participate in developmental pathways rather than a single tissue function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":8},{"id":"GO:0060707","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0060806","count":8}]},{"hash":"712369263689029279","title":"Neuronal signaling and locomotor behavior","description":"This cluster is dominated by GO terms related to ion channel activity (sodium/potassium transport), membrane depolarization, and neuronal signaling (EPSP, GABA pathway) alongside behavioral outputs such as startle response, locomotion, and conditioned taste aversion. These together suggest a cohesive theme of neural excitability driving movement and behavior, with a secondary hint of neuromuscular development.","confidence":"High","size":25,"edges":22,"triangles":2,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":10},{"id":"GO:0060079","count":10},{"id":"GO:0071805","count":10},{"id":"GO:0001964","count":9},{"id":"GO:0051899","count":9}]},{"hash":"1273459649664491514","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":33,"triangles":6,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0006406","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0002188","count":3},{"id":"GO:0000480","count":3}]},{"hash":"1129852158541989293","title":"Transmembrane Transporters","description":"This cluster is dominated by GO terms for various transmembrane transport processes (potassium, sodium, galactose, sialic acid, vitamin, nitrate/nitrite, xenobiotic), plus the neuronal context term of neurotransmitter loading into synaptic vesicles. Together these points indicate proteins involved in transporting diverse substrates across membranes, i.e., membrane transport proteins. A peripheral term about cell wall macromolecule catabolic process does not define the core theme. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071805","count":7},{"id":"GO:0035725","count":6},{"id":"GO:0016998","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0015757","count":4}]},{"hash":"1534774757118126777","title":"Neural development and Wnt signaling","description":"The cluster shows strong enrichment for neuronal morphogenesis (dendrite morphogenesis, positive regulation of axon extension, negative regulation of axonogenesis) and signaling, especially canonical Wnt signaling, with supporting terms like dopamine response. While immune-related terms (T cell receptor signaling, beta selection) appear, they likely reflect shared signaling components rather than a core immune function. Overall, the predominant theme is neural development and signaling.","confidence":"Medium","size":25,"edges":6,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":12},{"id":"GO:0048813","count":10},{"id":"GO:0050852","count":10},{"id":"GO:0043552","count":10},{"id":"GO:0006813","count":10}]},{"hash":"2252013259439490112","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0006368","count":2},{"id":"GO:0051083","count":1},{"id":"GO:0006620","count":1}]},{"hash":"993760491773825440","title":"Cardiac muscle contraction and heart development","description":"The terms cluster around cardiac muscle physiology\u2014cardiac muscle contraction, regulation of sarcomere organization, and heart rate modulation\u2014along with vascular smooth muscle regulation, implying a cardiovascular muscle function theme. The presence of transcription/splicing terms suggests underlying gene expression control supporting these heart-related processes.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:1904753","count":5},{"id":"GO:1904706","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0007275","count":4}]},{"hash":"2174845447277733140","title":"Ubiquitin-Dependent NF-\u03baB Immune Signaling","description":"The terms cluster around ubiquitination and proteolysis, NF-\u03baB regulation, NOD1 signaling, and inflammatory mediator production, with Vitamin D response and adipose-related differentiation suggesting immunometabolic links. Since no network edges are present, the label focuses on the shared function rather than a physical complex. Taken together, the dominant theme is ubiquitin-mediated regulation of innate immune signaling and inflammation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0016567","count":8},{"id":"GO:0032088","count":6},{"id":"GO:0016049","count":6},{"id":"GO:0045444","count":6},{"id":"GO:0033280","count":6}]},{"hash":"1834460585805886529","title":"Neural cell adhesion and axon guidance","description":"The cluster is dominated by GO terms for cell adhesion (cell-cell, homophilic, and heterophilic adhesion) and neural development (neuron migration, anterior/posterior axon guidance, nerve maturation), complemented by a term on clustering of voltage-gated sodium channels, which supports neuronal signaling. Though bone maturation and classical complement activation appear among the terms, they are less represented, so the primary theme is neural adhesion and guidance.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":10},{"id":"GO:0060445","count":9},{"id":"GO:0045162","count":9},{"id":"GO:0007156","count":9},{"id":"GO:0007157","count":9}]},{"hash":"1725935334889543146","title":"Vitamin and Ion Transmembrane Transporters","description":"This cluster centers on transmembrane transport of vitamins, ions, and xenobiotics, including vitamin C (L-ascorbic acid), D-glucose, sodium, potassium, and phosphate, as well as xenobiotic substrates. The GO terms suggest a set of membrane transport proteins with broad substrate specificity, possibly active in nutrient uptake and intestinal epithelial maintenance, hence a cohesive \u201cvitamin and ion transmembrane transport\u201d theme.","confidence":"High","size":25,"edges":17,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":25},{"id":"GO:0042908","count":25},{"id":"GO:0006855","count":25},{"id":"GO:0071805","count":25},{"id":"GO:0019852","count":23}]},{"hash":"1464604401491022123","title":"Unknown","description":"The Top Terms are highly diverse, spanning angiogenesis, chromatin/acetylation-related processes, and various metabolic pathways, with several items labeled obsolete. There is no single coherent function tying the proteins together, so Unknown with no confidence.","confidence":"","size":25,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001525","count":15},{"id":"GO:0060358","count":11},{"id":"GO:0018003","count":11},{"id":"GO:0006348","count":11},{"id":"GO:0006526","count":10}]},{"hash":"1229754466440491305","title":"Viral integration and host apoptosis","description":"The top GO terms emphasize DNA integration and proviral latency (GO:0015074, GO:0075713), along with apoptotic regulation and viral entry into host cells (GO:1902108, GO:0006915, GO:0075732). This pattern points to proteins involved in virus-host interactions centered on genome integration and subsequent host cell death, with some additional but less central hints toward symbiont interactions and developmental processes.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:1902108","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0007427","count":5},{"id":"GO:0035289","count":5}]},{"hash":"1526503864658317988","title":"Cardiac electrical activity and conduction","description":"The top GO terms cluster around SA node regulation, membrane depolarization in cardiac cells, calcium ion import, and SA node to atrial cardiac muscle communication, indicating a focus on cardiac electrophysiology and intercellular signaling. While there are a couple of neural differentiation terms present, the dominant signal points to cardiac conduction and action potential regulation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":4},{"id":"GO:0048709","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0010650","count":3}]},{"hash":"1963305327761203982","title":"Retroviral DNA Integration and Latency","description":"The most represented terms point to viral genome integration and proviral latency (DNA integration, establishment of integrated proviral latency) along with DNA replication and infection structure formation, suggesting a retroviral lifecycle theme. Some other terms seem incidental background signals (e.g., angiogenesis, integrin regulation). Overall, the cluster appears best described by retroviral integration/latency processes rather than a single host pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0008542","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0075713","count":3}]},{"hash":"292739918282414533","title":"Developmental and Xenobiotic Metabolism","description":"This cluster includes GO terms across reproductive development (female gonad development, prostate gland growth), lipid signaling (prostaglandin biosynthetic process), and developmental processes (response to vitamin D, lateral motor column neuron migration, platelet aggregation). It also strongly features xenobiotic and secondary metabolite metabolism (carbazole, isoquinoline alkaloid, dibenzo-p-dioxin catabolic, insecticide metabolic processes), suggesting proteins involved in both developmental regulation and detox/biotransformation pathways. Confidence: Medium","confidence":"","size":25,"edges":23,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":15},{"id":"GO:0001516","count":9},{"id":"GO:0033280","count":9},{"id":"GO:0046232","count":9},{"id":"GO:0070527","count":8}]},{"hash":"281200421088068190","title":"Amino acid and related small-molecule membrane transport","description":"Based on the GO terms, the cluster centers on transport across the plasma membrane for amino acids (arginine, ornithine, D-serine) and related metabolites (carnitine), with a tie to nitric oxide production in inflammatory response. This points to a common function of membrane transport enabling amino acid supply and signaling, despite some unrelated terms (molting cuticle, hypotonic response) that may reflect annotation noise or cross-species terms.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0048632","count":2},{"id":"GO:0097638","count":2},{"id":"GO:1902274","count":2}]},{"hash":"1269414734970804134","title":"Ubiquitin-ERAD Regulation","description":"The top GO terms cluster around ubiquitin-dependent ER-associated degradation (ERAD) and regulation of ubiquitin/protease activity, indicating proteins involved in ubiquitin-mediated protein quality control. While a few terms touch on translation initiation, nuclear envelope reassembly, or chromatid dynamics, these appear secondary; the dominant signal is ubiquitin/ERAD-related regulation, suggesting a cohesive theme of protein quality control via ubiquitin tagging and ERAD pathways.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:1903094","count":3},{"id":"GO:2000157","count":3},{"id":"GO:0001732","count":2},{"id":"GO:0031468","count":2}]},{"hash":"1029145914867911289","title":"GPCR-cAMP signaling in neural and metabolic regulation","description":"The cluster shows strong enrichment for GPCR-mediated activation of adenylate cyclase and cAMP signaling, with links to blood pressure regulation, thermogenesis, and metabolic energy processes (electron transport). Neural aspects are evident from pain perception and acetylcholine metabolism, alongside immune modulation via chemokine regulation. Together, these terms point to a coordinated GPCR-driven signaling module coordinating neural, metabolic, and cardiovascular responses.","confidence":"High","size":24,"edges":26,"triangles":0,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0007190","count":21},{"id":"GO:0010579","count":21},{"id":"GO:0002024","count":21}]},{"hash":"1275118601933494869","title":"Gonadal development and prostaglandin biosynthesis","description":"The cluster is dominated by GO terms related to reproductive development, especially female gonad development, uterus development, and prostaglandin biosynthesis, with additional related terms like prostate gland growth. While several xenobiotic and metabolic terms appear (insecticide, alkaloid, cholesterol catabolic processes), the strongest and most representative signal centers on gonadal development and prostaglandin pathways, guiding the label toward reproductive development. ","confidence":"Medium","size":24,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":16},{"id":"GO:0001516","count":14},{"id":"GO:0060065","count":14},{"id":"GO:0060736","count":13},{"id":"GO:0017143","count":13}]},{"hash":"878580297077878664","title":"Liver Metabolism and Notch Signaling","description":"This cluster centers on metabolic processes typical of liver physiology\u2014fatty acid beta-oxidation, ketone body biosynthesis, porphyrin biosynthesis, and amino acid catabolism\u2014with the added presence of liver development and Notch signaling terms. The convergence of energy/metabolite production pathways and a key developmental signaling pathway suggests a cohesive theme around hepatic metabolism linked to developmental regulation, despite an outlier term (antibiotic biosynthetic process) that may reflect annotation noise. Confidence: Medium","confidence":"","size":24,"edges":257,"triangles":1669,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006635","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0042594","count":6},{"id":"GO:0001889","count":6},{"id":"GO:0046951","count":6}]},{"hash":"1711209398360154671","title":"DNA Repair and Oxidative Stress Response","description":"This cluster centers on DNA repair and redox-related processes: base-excision repair, DNA catabolic processes, cellular response to hydrogen peroxide, and maintenance of redox homeostasis. The presence of xenobiotic response signals a broader stress-detoxification role as well. While a few development-specific terms (follicle epithelium polarity, egg chamber structures) reflect tissue context, the dominant theme is genome maintenance under oxidative stress, consistent with proteins involved in DNA repair and redox regulation in insects. Confidence: High","confidence":"","size":24,"edges":78,"triangles":75,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0006284","count":4},{"id":"GO:0001744","count":3},{"id":"GO:0007299","count":3}]},{"hash":"582168305870728056","title":"Retroviral DNA integration and latency","description":"This cluster\u2019s top GO terms center on DNA integration, reverse-transcription\u2013related DNA synthesis, and proviral latency establishment, along with virus-host entry processes, all characteristic of retroviral replication cycles and integration into the host genome. Confidence reflects a strong, coherent retroviral-theme signal.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0090502","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1752841624648226194","title":"Lipid Metabolism","description":"This cluster is dominated by GO terms related to lipid metabolism: lipid digestion, ceramide biosynthetic process, and triglyceride catabolic process, indicating a cohesive lipid-centric theme. There are also terms related to protein localization to the cell surface and several organ/tissue development terms, suggesting broader functional contexts for some members. Overall, Lipid Metabolism is a representative label for this cluster despite some additional, less cohesive terms.","confidence":"Medium","size":24,"edges":33,"triangles":28,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0044241","count":3},{"id":"GO:0046513","count":3},{"id":"GO:0034394","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0046627","count":2}]},{"hash":"1715040748433126071","title":"Ion channel\u2013mediated neuronal signaling and circadian behavior","description":"Top terms reveal a focus on ion transport across membranes (K+, Na+, Ca2+), GABAergic signaling, and excitatory postsynaptic potentials, together with behavioral/physiological processes such as locomotion, startle response, conditioned taste aversion, and circadian sleep/wake regulation. The convergence of ion-channel activity and neurotransmitter pathways implies proteins in this cluster govern neuronal signaling strength and timing, affecting circadian behavior and learning-related responses.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":21},{"id":"GO:0045188","count":20},{"id":"GO:0001964","count":20},{"id":"GO:0098703","count":20},{"id":"GO:0007626","count":17}]},{"hash":"501392930352568140","title":"Translation Machinery and Ribosome Regulation","description":"This cluster is dominated by GO terms tied to translation and ribosome function, including cytoplasmic and mitochondrial translation, translational termination/elongation, and ribosome disassembly, indicating a cohesive group of proteins involved in protein synthesis machinery and its regulation across cellular compartments. Some RNA-processing terms appear\u2014likely ancillary\u2014yet the core signal centers on translation and ribosome dynamics.","confidence":"High","size":24,"edges":111,"triangles":377,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0006415","count":4},{"id":"GO:0000288","count":3},{"id":"GO:0070126","count":3},{"id":"GO:0046782","count":3}]},{"hash":"744574947428276831","title":"RNA Processing and Translational Initiation Regulation","description":"The cluster is enriched for translation initiation terms (translation reinitiation, preinitiation complex formation, IRES-dependent initiation) and for RNA processing/splicing and mRNA stability regulation, suggesting a coherent role in RNA metabolism and control of translation.","confidence":"High","size":24,"edges":15,"triangles":0,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":17},{"id":"GO:0001731","count":17},{"id":"GO:1901407","count":16},{"id":"GO:0006446","count":16},{"id":"GO:0075522","count":16}]},{"hash":"316351999051146240","title":"Neuronal actin dynamics and synaptic plasticity","description":"The cluster is dominated by GO terms linking actin cytoskeleton organization and Rho signaling (driving cytoskeletal remodeling), with strong signals for synaptic plasticity (positive regulation of synapse structure, EPSP regulation, and long-term depression) and sensory perception of sound, indicating a neural context. Some terms (heart development, endothelial barrier) appear as peripheral or pleiotropic associations, but the core theme centers on neuronal cytoskeleton remodeling and synaptic adaptation.","confidence":"High","size":24,"edges":26,"triangles":4,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0030036","count":4},{"id":"GO:0090557","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0051835","count":4}]},{"hash":"2242720644094105039","title":"Meiotic germline microtubule organization","description":"Top GO terms indicate microtubule nucleation and organization, including positive regulation of microtubule polymerization and meiotic telomere attachment to the nuclear envelope, pointing to a cluster of proteins involved in meiotic spindle and nuclear envelope dynamics in germline cells. Some unrelated terms appear (e.g., heart formation, TGF-beta signaling) but do not override the MT/meiosis signal.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031116","count":3},{"id":"GO:0007020","count":3},{"id":"GO:0031122","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0060250","count":1}]},{"hash":"1950314601162066246","title":"Neurocardiac Developmental Signaling","description":"The top GO terms cluster around signaling pathways and developmental processes in neural and cardiac contexts: Wnt signaling regulation, ventricular cardiac muscle development, Bergmann glial differentiation, glutamatergic synaptic transmission, and excitatory postsynaptic potentials, plus intracellular signal transduction. While telomere maintenance terms appear, they are less central to the shared theme, so the label focuses on signaling-driven development across neural and heart tissues.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":4},{"id":"GO:1904355","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0055015","count":3},{"id":"GO:0097284","count":3}]},{"hash":"791700510499952048","title":"Chromatin Modification and DNA Repair","description":"The cluster shows enrichment in histone ubiquitination (H2B), heterochromatin boundary formation, and transcription-coupled nucleotide-excision repair, all pointing to chromatin state regulation and genome maintenance. The presence of a cell cycle term supports mitotic linkage, while a couple of broader terms like microtubule regulation and apoptosis hint at related cell-cycle and stress responses. Overall, the dominant theme appears to be chromatin remodeling and DNA repair.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031116","count":2},{"id":"GO:1900118","count":2},{"id":"GO:0090156","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0050936","count":1}]},{"hash":"1365304122961549709","title":"Xenobiotic detoxification and metabolism","description":"The cluster's top GO terms center on xenobiotic and toxin metabolism, including xenobiotic catabolic process, insecticide metabolic process, isoquinoline alkaloid metabolic process, and dibenzo-p-dioxin catabolic process. Additional related terms like cholesterol catabolic process and oxidative deethylation support a detox/biotransformation theme. A few items such as DNA replication and prostate gland growth appear as annotations that may be less representative of this cluster's core function.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042738","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0060736","count":2},{"id":"GO:0017143","count":2},{"id":"GO:0033076","count":2}]},{"hash":"2197531711493477592","title":"Renal development and innate immunity","description":"The cluster includes GO terms for metanephric proximal tubule development, mesonephric duct development, and metanephric ascending thin limb development, indicating a renal development theme, while also featuring innate immune signaling terms (C-type lectin receptor signaling, phagocytosis recognition, NK cell chemotaxis regulation), suggesting a combined kidney-associated and immune-ready function.","confidence":"Medium","size":24,"edges":81,"triangles":69,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":13},{"id":"GO:0072237","count":12},{"id":"GO:0051873","count":12},{"id":"GO:0072177","count":12},{"id":"GO:2000502","count":12}]},{"hash":"2021106758899313568","title":"Neural behavior and opioid response","description":"The top GO terms are dominated by neural/behavioral processes (prepulse inhibition, social behavior, suckling behavior) and opioid signaling (response to morphine), suggesting a theme around nervous system signaling and behavioral responses. There are outliers related to osteoblast differentiation and general protein localization, indicating some functional diversity. Given the modest cohesion and lack of interaction data (Edges: 0), this label is a reasonable, but not definitive, generalization.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001649","count":3},{"id":"GO:0060134","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0001967","count":2}]},{"hash":"1392227511431182425","title":"Collagen-driven cartilage and eye morphogenesis","description":"This cluster is dominated by collagen-related processes: cartilage condensation, collagen fibril organization, and collagen-activated signaling, along with a term for camera-type eye morphogenesis. These suggest a coherent theme of collagen-rich extracellular matrix guiding vertebrate tissue formation in cartilage and the eye. Other terms like cell adhesion regulation and immune-related complement activity may reflect peripheral aspects of ECM remodeling and tissue interaction, while some housekeeping terms (lipid/metabolic processes, ion transport) are likely background noise. Overall, the core function appears to be collagen-mediated vertebrate tissue morphogenesis, especially cartilage and ocular development.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0001502","count":8},{"id":"GO:0038063","count":7},{"id":"GO:0048593","count":6},{"id":"GO:0006813","count":5},{"id":"GO:0030199","count":5}]},{"hash":"579598677041994552","title":"Skin and adipocyte development","description":"Top GO terms point to skin development and fat cell differentiation, along with broader multicellular organism development and proliferation, suggesting the proteins cluster around tissue formation in skin and adipose tissue. Other terms like translation initiation and actin filament depolymerization may reflect general developmental regulation rather than a core theme. Overall, a development-focused label centered on skin and adipose tissue is appropriate.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0035544","count":5},{"id":"GO:0045444","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0002188","count":5}]},{"hash":"1751612190640637738","title":"Cell cycle progression and DNA replication","description":"The top GO terms are dominated by cell-cycle and DNA replication processes (meiotic cell cycle, G1/S transition of the mitotic cycle, DNA replication, protein localization to kinetochore). Although neural development and xenobiotic response terms appear, the strongest recurring theme is cell-cycle\u2013related functions, suggesting the cluster largely represents cell cycle progression and replication machinery. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042220","count":4},{"id":"GO:0051321","count":4},{"id":"GO:0000082","count":4},{"id":"GO:0034501","count":4},{"id":"GO:0014044","count":4}]},{"hash":"243370708577982671","title":"Embryonic development and organogenesis","description":"The proteins show strong enrichment for GO terms related to embryonic development and morphogenesis (cartilage/ skeletal development, placental/trophoblast differentiation, endocrine system development, left-right patterning, and EMT in heart cushion formation). A single spliceosome term is present but minor, so the dominant theme is developmental processes and organ formation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":10},{"id":"GO:0060707","count":10},{"id":"GO:0035270","count":10},{"id":"GO:0003323","count":10},{"id":"GO:0060806","count":10}]},{"hash":"594502246491680890","title":"Embryonic organogenesis and heart formation","description":"The top GO terms point to developmental processes across multiple organs (endocrine system development, cartilage morphogenesis, placenta-related differentiation, left-right patterning, and endocardial cushion EMT), with additional signaling (receptor clustering) and some immune-related terms. This suggests a cluster of proteins involved in embryonic organogenesis, particularly cardiovascular development, rather than a single specialized pathway. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0060536","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5}]},{"hash":"981986881278906270","title":"Developmental Transcription Regulators","description":"Dominant GO term is transcription by RNA polymerase II, with diverse embryonic development terms (vascular, placental, neural and organogenesis). This points to a cluster of proteins involved in regulating transcription during development, i.e., developmental transcription regulators.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0035470","count":10},{"id":"GO:0060426","count":9},{"id":"GO:0035881","count":9},{"id":"GO:0001756","count":9}]},{"hash":"15718795270778382","title":"DNA replication and chromatin organization","description":"The top GO terms emphasize replication initiation, meiotic recombination nodule assembly, heterochromatin formation, and historic DNA unwinding/replication protection\u2014collectively pointing to DNA replication and chromatin maintenance. There are some outliers (cilium movement, root meristem regulation, gas vesicle organization, cAMP response) that may reflect annotation noise or pleiotropy, but the core signal suggests this cluster mainly covers genome replication and chromatin dynamics.","confidence":"Medium","size":23,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051591","count":3},{"id":"GO:0007292","count":3},{"id":"GO:0031412","count":3},{"id":"GO:0006343","count":3},{"id":"GO:0006268","count":3}]},{"hash":"1717637739318278705","title":"RNA Polymerase II Transcription Regulation","description":"Top GO terms show strong enrichment for both positive and negative regulation of transcription by RNA polymerase II, suggesting the cluster predominantly comprises transcription regulators acting on RNAP II. Other terms, including heart and midbrain development, pancreas morphogenesis, multicellular growth, and RNA/tRNA modification, are present but appear secondary. Thus, the shared theme is regulation of transcription by RNAP II.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0007507","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0035264","count":5}]},{"hash":"899811524556102893","title":"DNA transposition and Pol II transcription regulation","description":"The top GO terms are dominated by DNA transposition and negative regulation of transcription by RNA polymerase II, implying a nuclear/nucleic-acid\u2013related cluster. A few RNA-processing terms (snRNA pseudouridine synthesis) support a transcription/processing theme, but several other single-occurrence metabolic terms suggest heterogeneity. The strongest cohesive signal is nucleic-acid dynamics and transcription control, justifying this label.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0090305","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0042558","count":1},{"id":"GO:0050666","count":1}]},{"hash":"1938550775980170004","title":"Small-molecule biosynthesis and catabolism","description":"The Top Terms show a strong lean toward biosynthesis and degradation of small molecules (antibiotics, clavulanic acid, carnitine, xanthine, herbicide metabolites). A few terms relate to cell cycle regulation and signaling (NF-kappaB, cytokinesis), which are less consistently aligned, but the metabolic theme dominates, supporting this label.","confidence":"Medium","size":23,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0045329","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0006151","count":3},{"id":"GO:0033050","count":3}]},{"hash":"1569992375991468773","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":252,"triangles":1750,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0006412","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000462","count":5},{"id":"GO:0007338","count":5}]},{"hash":"681458084704904756","title":"Steroid Hormone Biosynthesis and Redox Regulation","description":"The most represented terms are oxidation-reduction processes and steroid hormone biosynthesis (testosterone and androgen metabolic processes), along with redox homeostasis, suggesting a module where redox state intersects with steroid biosynthesis. Some other terms (antibiotic biosynthesis, poly-hydroxybutyrate biosynthesis, aging, lung development) appear tangential or broader in scope, but the dominant theme remains redox-linked metabolism and steroid production.","confidence":"Medium","size":23,"edges":30,"triangles":11,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0017000","count":7},{"id":"GO:0061370","count":6},{"id":"GO:0008209","count":6},{"id":"GO:0006355","count":6}]},{"hash":"470696615207481274","title":"Ribosome Biogenesis and rRNA Maturation","description":"The top GO terms are dominated by maturation and processing of rRNA (LSU/SSU, 5.8S) and overall ribosome biogenesis, indicating this cluster centers on ribosome assembly. Connected terms like DNA replication and cell division suggest the proteins are involved in growth-related processes that couple ribosome production with the cell cycle. Although a couple of terms are less clearly related (e.g., some developmental annotations), the dominant signal is ribosome biogenesis and rRNA maturation.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000462","count":3}]},{"hash":"1482615817715906019","title":"DNA-templated transcription and cell cycle cluster","description":"This cluster centers on transcriptional regulation and cell-cycle control, with GO terms for DNA-templated transcription, mitotic cell cycle, and regulation of cytokinesis, plus development signaling (multicellular organism development) and NF-kappaB\u2013related signaling, indicating a cohesive theme of coordinating gene expression with cell division and developmental cues. Some terms (e.g., XDP catabolic processes, folic acid biosynthesis) appear less central and may reflect broader background annotations; the core signal is transcriptional regulation coupled to cell-cycle and signaling pathways.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0032465","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1249945440534382189","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0045892","count":2},{"id":"GO:0030154","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0006313","count":2}]},{"hash":"1534750806071548012","title":"Mitochondrial respiration and redox signaling","description":"The cluster prominently features GO terms tied to mitochondrial electron transport and aerobic respiration (ubiquinol to cytochrome c, proton transport), plus cellular oxidant detoxification and ascorbate metabolism, signaling a focus on energy production and redox balance. Stress-related signaling and proliferative control terms (regulation of JNK cascade, DNA damage response via p53) suggest the cluster also captures redox- and energy-linked stress responses. A prostaglandin biosynthetic term appears but is less central; overall the common theme is mitochondrial energy metabolism with redox regulation and associated stress signaling.","confidence":"High","size":23,"edges":10,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0006122","count":2},{"id":"GO:0009060","count":2},{"id":"GO:1902600","count":2}]},{"hash":"96989821057519376","title":"Muscle, nerve, and vascular development","description":"The top GO terms cluster around development and remodeling of skeletal and cardiac muscle, neural components (Schwann cell development, substantia nigra development), and blood vessel formation, with calcium signaling involvement; this points to a cohesive theme of coordinated development across muscle, nerve, and vascular tissues.","confidence":"High","size":23,"edges":32,"triangles":10,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0001569","count":5},{"id":"GO:0014044","count":5},{"id":"GO:0035562","count":5},{"id":"GO:0021762","count":5},{"id":"GO:0014883","count":5}]},{"hash":"286798694691956677","title":"Diverse Transmembrane Transporters","description":"The top GO terms point to a broad set of transmembrane transport activities across ions (sodium, potassium), nutrients (galactose, vitamins, nitrate/nitrite), sugars, and xenobiotics, along with a role in neurotransmitter loading into synaptic vesicles. This pattern suggests the cluster comprises membrane transporter proteins specialized for moving a variety of substrates across cellular membranes, rather than a single tight pathway. The diversity of substrates represented supports a transporter-centric interpretation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0042128","count":4},{"id":"GO:0035461","count":3},{"id":"GO:0015757","count":3}]},{"hash":"881524330762886464","title":"Neural development and myelination","description":"The enrichment centers on CNS development, myelination, paranode axon localization, and signaling pathways (Wnt, FGFR\u2192MAPKKK) that govern neural differentiation and glial maturation. While some terms touch on skeletal/biomineral development, the shared theme is neural development and myelin formation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016055","count":4},{"id":"GO:0014909","count":4},{"id":"GO:0002175","count":4},{"id":"GO:0030194","count":4},{"id":"GO:0007417","count":4}]},{"hash":"641962115154827826","title":"RNA splicing and translation initiation regulation","description":"This cluster centers on post-transcriptional RNA processing, including spliceosome-mediated splicing (both regular and alternative), regulation of mRNA processing and translation initiation, and associated decay pathways, indicating a cohesive theme of RNA processing and translational control. The uterus development term is likely incidental; the dominant signal is RNA processing/regulation.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0000184","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0045292","count":2}]},{"hash":"99771052801839432","title":"Ubiquitin-Proteasome Regulation of Apoptosis and Cell Cycle","description":"This cluster is dominated by GO terms for apoptotic process, mitotic cell cycle, mitotic spindle assembly, and SCF-dependent ubiquitin-proteasomal degradation, plus protein ubiquitination. These together point to a coordinated role of ubiquitin-mediated protein turnover in controlling cell fate decisions and cell-cycle progression, including spindle dynamics. Some terms (e.g., forebrain development, DNA transposition) are less central but do not override the core theme of ubiquitin-regulated cell survival and division.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0006313","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0000278","count":2}]},{"hash":"271822431969120766","title":"mRNA Splicing and Translation Initiation Regulation","description":"This cluster is characterized by GO terms focused on splicing regulation via the spliceosome, alternative mRNA splicing, and formation of translation initiation complexes, along with connected regulatory processes like TORC1 signaling and GTPase activity. The shared theme is coordinated post-transcriptional control of gene expression, encompassing both mRNA processing and the initiation/reinitiation of translation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0000380","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3}]},{"hash":"898018256764638610","title":"Lipid biosynthesis and hypoxia response","description":"The top GO terms are dominated by lipid metabolism (mannosyl-inositol phosphorylceramide metabolism, ergosterol biosynthesis regulation, unsaturated fatty acid biosynthesis) and stress-related processes (cellular response to hypoxia), with a few outliers that may reflect cross-species annotations (sebaceous gland differentiation, CNS myelin maintenance). This suggests a broad theme of lipid biosynthesis coupled with stress adaptation, rather than a single, tightly defined pathway.","confidence":"Medium","size":23,"edges":22,"triangles":1,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006675","count":6},{"id":"GO:0001949","count":5},{"id":"GO:0006809","count":5},{"id":"GO:0032443","count":5},{"id":"GO:0042128","count":5}]},{"hash":"327584587896326959","title":"Mechanosensory and Cardiac Ion Channel Signaling","description":"This cluster centers on mechanosensation and ion transport with membrane potential changes, including sensory pain and touch detection, and cardiac excitability (atrial action potential, repolarization, hyperpolarization, and calcium response). The top GO terms point to mechanotransduction and potassium/calcium ion channel activity as common themes, linking touch/pain sensing to cardiac electrical signaling. The lack of edges doesn\u2019t negate a coherent functional theme, as these proteins may participate in related pathways rather than a single complex. Overall, the label captures the shared function of ion-channel\u2013mediated signaling in mechanosensation and cardiac excitability.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0050976","count":5},{"id":"GO:0098914","count":5},{"id":"GO:0071805","count":5}]},{"hash":"452291954400343307","title":"Meiosis and Germ Cell Development","description":"The cluster is dominated by GO terms related to meiosis and germ cell maturation, including meiotic chromosome condensation, establishment of sister chromatid cohesion (mitotic and meiotic), synaptonemal complex assembly, meiosis I, oocyte maturation, and seminiferous tubule development. A few immune-related isotype switching terms appear but are infrequent and likely not defining the cluster\u2019s core function. Overall, the proteins seem to converge on meiotic chromosome dynamics and germ cell development.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045190","count":3},{"id":"GO:0048298","count":3},{"id":"GO:0010032","count":2},{"id":"GO:0072520","count":2},{"id":"GO:0034087","count":2}]},{"hash":"1494524679188984305","title":"Retroviral DNA integration and replication","description":"The top GO terms cluster around DNA integration, proviral latency, reverse transcription (RNA-templated DNA biosynthesis), DNA replication, and viral entry into the host nucleus, which together delineate a retroviral-like life cycle and host interaction; additional terms on symbiont entry and RNAi modulation support a broader host\u2013pathogen interaction context.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0075713","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0075732","count":4}]},{"hash":"1371160253618132371","title":"Neurodevelopment and synaptic signaling","description":"The dominant GO terms point to nervous system and brain development, learning, and signaling processes (ROBO/roundabout, Smoothened/hedgehog pathways, ERK cascade, calcium-dependent exocytosis), suggesting a cluster tied to neural development and synaptic communication. Some terms like kidney development and T cell signaling appear as outliers, but the core enrichment centers on neural patterning, development, and neurotransmission.","confidence":"High","size":23,"edges":51,"triangles":15,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":10},{"id":"GO:0007224","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0035385","count":9},{"id":"GO:0050852","count":9}]},{"hash":"1114033268403262473","title":"Unknown","description":"The top GO terms show a highly heterogeneous mix (proteasome assembly and ubiquitin-dependent protein catabolism alongside plant-related processes like stamen formation and chlorophyll biosynthesis, plus hyaluronan metabolism, cell adhesion, dendrite regeneration, and blood coagulation) with no single dominant function or shared pathway. There are no edges, implying no apparent interaction pattern to tie these terms into a coherent cluster.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0043248","count":10},{"id":"GO:0006511","count":10},{"id":"GO:0048455","count":10},{"id":"GO:0015995","count":10},{"id":"GO:0030212","count":10}]},{"hash":"342995413777835791","title":"Viral entry, DNA integration, and proviral latency","description":"This cluster is dominated by GO terms related to viral processes: DNA integration, establishment of integrated proviral latency, viral penetration into the host nucleus, and general symbiont (virus) entry into host cells. These point to a cohesive theme of viral infection steps and genome integration. Some terms related to phosphorylation and brain development appear less central and may reflect broader signaling or incidental associations rather than core function.","confidence":"Medium","size":23,"edges":22,"triangles":1,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0075713","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3}]},{"hash":"2245617138845401070","title":"Developmental signaling and morphogenesis","description":"This cluster centers on developmental processes and morphogenesis, with terms like heart development and branching in labyrinthine layer morphogenesis, alongside signaling regulation (GTPase activity, tyrosine phosphorylation) and TGF-beta response. Actin crosslink formation points to cytoskeletal remodeling essential for morphogenesis, while hypoxia response and mitotic cell cycle reflect dynamic cellular states during development. Together, these terms suggest a theme of signaling-driven morphogenesis and cytoskeletal changes in developing tissues.","confidence":"Medium","size":23,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0031954","count":5},{"id":"GO:0071456","count":5},{"id":"GO:0071560","count":4},{"id":"GO:0060670","count":4}]},{"hash":"1772594948645975461","title":"Choline and Phospholipid Biosynthesis","description":"This cluster centers on GO terms tied to choline metabolism and phospholipid biosynthesis, including the CDP-choline pathway, phosphatidylethanolamine biosynthesis, and related choline/ethanolamine metabolic processes, suggesting a cohesive lipid membrane biosynthesis module. While a couple of terms refer to general stress responses (e.g., response to antibiotic), the dominant theme is membrane lipid production and choline utilization, with peripheral metabolic connections like threonine and methionine salvage unlikely to define the core function. Confidence is high that this label captures the main shared function of the proteins in the cluster.","confidence":"High","size":23,"edges":43,"triangles":46,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0046677","count":7},{"id":"GO:0016310","count":6},{"id":"GO:0019284","count":5},{"id":"GO:0019509","count":5},{"id":"GO:0009088","count":5}]},{"hash":"545917648844686741","title":"Ubiquitin-mediated proteostasis and autophagy","description":"This cluster is dominated by GO terms for ubiquitination processes (protein deubiquitination, protein autoubiquitination) and ERAD, plus autophagy-related terms (aggrephagy), pointing to a core function in protein quality control. While there are related terms for transcription regulation and organelle dynamics, the strongest signal ties proteins to ubiquitin-dependent turnover and autophagic pathways that maintain proteome homeostasis.","confidence":"High","size":23,"edges":252,"triangles":1750,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":14},{"id":"GO:0030433","count":8},{"id":"GO:0006357","count":7},{"id":"GO:1904021","count":7},{"id":"GO:0000753","count":7}]},{"hash":"799097051037083301","title":"Membrane Transporters and Vesicle Loading","description":"The cluster shows a clear pattern of transmembrane transport for a variety of substrates (galactose, vitamin, sialic acid, fucose, nitrate/nitrite, xenobiotics) and includes a term about loading neurotransmitters into synaptic vesicles, suggesting a shared theme of membrane transport and vesicle-associated processes. Some terms like protein heterooligomerization and response to toxic substances are broader, but overall the dominant function appears to be transport-related.","confidence":"Medium","size":23,"edges":27,"triangles":7,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":4},{"id":"GO:0051291","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0015757","count":4},{"id":"GO:0015739","count":4}]},{"hash":"707409221196920934","title":"Telomere maintenance and mitosis regulation","description":"The top GO terms point to telomere biology (telomerase regulation, telomere length regulation, telomere-associated cohesion) alongside mitotic/cytoskeletal roles (spindle assembly, actin bundle formation, response to mechanical stimulus), suggesting a cluster of proteins involved in chromosome end maintenance and cell division machinery. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":9},{"id":"GO:0032212","count":8},{"id":"GO:0007205","count":8},{"id":"GO:0051017","count":8},{"id":"GO:0051225","count":8}]},{"hash":"1232356000019786454","title":"Immune signaling and lymphocyte development","description":"This cluster is dominated by immune-related GO terms such as interleukin-4 production, B cell affinity maturation, NK T cell differentiation, and cellular response to IL-7, pointing to proteins involved in immune signaling and lymphocyte development. Additional terms on endocytosis and cell migration support a theme of immune cell trafficking. Some non-immune terms appear (heart development, insulin signaling), but the immune signals are prominent, giving a plausible, cohesive theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0032633","count":5},{"id":"GO:0002344","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0001865","count":5},{"id":"GO:0016477","count":5}]},{"hash":"89071199134989770","title":"Embryonic morphogenesis and organ development","description":"The dominant terms center on embryonic tissue formation, cartilage morphogenesis, placental/placental-related organogenesis, and left-right patterning, with related heart development processes via EMT in endocardial cushion. These indicate a coherent theme of developmental morphogenesis. A few terms (mRNA splicing and ribosome export) are general cellular processes and do not alter the main interpretation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":18},{"id":"GO:0060707","count":18},{"id":"GO:0035270","count":18},{"id":"GO:0003323","count":18},{"id":"GO:0060806","count":18}]},{"hash":"1018063492591875505","title":"Developmental signaling and morphogenesis","description":"The top GO terms show Rho/GTPase signaling, cytoskeletal/membrane trafficking processes (cell migration, exocytosis, synapse organization), and development-specific activities (posterior head segmentation, oskar mRNA translation), pointing to a group coordinating signaling, cytoskeletal dynamics, and morphogenesis during development (notably in Drosophila-like contexts). Medium","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:1902108","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0007427","count":2},{"id":"GO:0035289","count":2}]},{"hash":"230915766608765845","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0000494","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0051096","count":2},{"id":"GO:0008380","count":2}]},{"hash":"419395321314836626","title":"RNA processing and ribosome biogenesis","description":"Predominant signals are RNA processing and ribosome maturation, including RNA guanine-N7 methylation, mRNA capping, and tRNA wobble uridine modification, plus ribosomal small subunit export from the nucleus, which together point to RNA maturation and ribosome biogenesis. Other terms (vitamin biosynthesis, xenobiotic response, nodulation) are present but appear less central to this cluster\u2019s core function.","confidence":"Medium","size":22,"edges":10,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":14},{"id":"GO:0006370","count":14},{"id":"GO:0009236","count":14},{"id":"GO:0035690","count":13},{"id":"GO:0017000","count":13}]},{"hash":"126657663823250447","title":"Transcription and metabolic biosynthesis cluster","description":"Top GO terms point to DNA-templated transcription alongside multiple biosynthetic and metabolic processes (pyruvate, cobalamin, heme, threonine), plus cell division and signaling pathways (Notch, insulin response, kynurenine catabolic). This suggests a group of proteins linking transcriptional regulation with diverse metabolism and growth-related signaling, rather than a single specialized function. Confidence: Medium","confidence":"","size":22,"edges":155,"triangles":589,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0042866","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0009236","count":5},{"id":"GO:0019346","count":4}]},{"hash":"1668982714189931101","title":"Organogenesis and angiogenesis with developmental signaling","description":"The cluster is dominated by developmental processes: angiogenesis (GO:0001525) and multiple organ/tissue development terms (multicellular organism development, heart development, Schwann cell development, myoblast fusion), suggesting a cohesive theme of vascular, neural, and muscle organogenesis. The presence of mitotic cell cycle terms (G2/M transition, mitotic cell cycle) indicates concurrent cell proliferation typical of developing tissues. A plant-specific term (abscisic acid-activated signaling) appears as an outlier. Overall, the group reflects developmental programs driving tissue formation and vascularization, with associated cell-cycle activity.","confidence":"High","size":22,"edges":78,"triangles":152,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":13},{"id":"GO:1902896","count":12},{"id":"GO:0051000","count":12},{"id":"GO:0007275","count":12},{"id":"GO:0014044","count":11}]},{"hash":"1648763407288226117","title":"Ribosome biogenesis and translational regulation","description":"The cluster is dominated by GO terms related to translation and ribosome maturation (translation, rRNA base methylation, maturation of LSU-rRNA) indicating a core function in ribosome assembly and protein synthesis control; transcription terms are present but secondary, and the lipid/ubiquinone-related terms likely reflect broader cellular context or annotation noise.","confidence":"Medium","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006351","count":2},{"id":"GO:1901006","count":2},{"id":"GO:0055088","count":2},{"id":"GO:0010795","count":2}]},{"hash":"1628551004099996773","title":"RNA Methylation and Translation Initiation","description":"The cluster is enriched in GO terms related to methylation of RNA species (guanine-N7 methylation in RNA and rRNA, tRNA methylation) and steps of translation initiation (translation reinitiation, formation of translation preinitiation complex). This suggests proteins involved in RNA modification plus components of the translation initiation machinery. Other terms such as antibiotic/biotin biosynthesis, chromatin remodeling, and cellular responses likely reflect ancillary roles or annotation noise, but the dominant theme is RNA modification linked to translation initiation.","confidence":"High","size":22,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0070476","count":2}]},{"hash":"594702537971815011","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by translation and ribosome-related processes (translation GO:0006412; cytoplasmic translation GO:0002181; ribosome biogenesis GO:0042254; ribosomal subunit assembly GO:0000028; cytoplasmic translational termination GO:0002184). Additional signals point to mitochondrial involvement (protein import into mitochondrial matrix GO:0030150) and iron-sulfur cluster assembly (GO:0016226), which relate to mitochondrial ribosome function and biogenesis. Taken together, this cluster appears to group proteins involved in ribosome assembly and translation machinery.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0016226","count":2},{"id":"GO:0002184","count":2}]},{"hash":"1536115218695830174","title":"Immune signaling and inflammatory regulation","description":"The cluster\u2019s top GO terms are dominated by innate immune signaling and inflammatory responses, including regulation of Toll-like receptor signaling, cellular response to lipopolysaccharide, and chemokine production, with additional links to necroptosis and cell-cycle regulation. This suggests the proteins collectively participate in modulating immune signaling and inflammatory processes, despite some supporting terms related to development or transcription.","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0019800","count":3},{"id":"GO:0060173","count":3},{"id":"GO:0051497","count":3},{"id":"GO:0001558","count":3}]},{"hash":"410599216476757645","title":"Neuronal signaling and synaptic plasticity","description":"This cluster's top GO terms cluster around neural signaling and plasticity, including regulation of neuronal synaptic plasticity, activation of adenylate cyclase, calcium release into the cytosol, and regulation of GTPase activity\u2014hallmarks of neuronal signal transduction and synaptic modulation. Some terms like inflammatory response and nitrate assimilation appear as broader annotations but do not override the central neural signaling theme. Overall, the annotation pattern supports a neural signaling/plasticity module.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0001975","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0008284","count":2}]},{"hash":"2175386834819217401","title":"Sphingolipid and Fatty Acid Biosynthesis","description":"The cluster shows strong enrichment for sphingolipid metabolism (sphinganine and sphingosine biosynthesis) and fatty acid biosynthesis/reactivity, including monounsaturated fatty acid synthesis and response to fatty acids, suggesting a lipid biosynthesis module. A few terms related to cell adhesion or skin-regulatory processes appear but are likely peripheral to the main lipid-focused function.","confidence":"High","size":22,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:0010873","count":3},{"id":"GO:0006667","count":2},{"id":"GO:0046512","count":2},{"id":"GO:0010205","count":2}]},{"hash":"138739220559370137","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097498","count":3},{"id":"GO:0051531","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0000472","count":3}]},{"hash":"1066729186508562086","title":"Mitochondrial Transport and Redox Metabolism","description":"This cluster centers on mitochondrial functions, with multiple terms tied to the transport of metabolites and ions across the mitochondrial membrane (citrate, iron, magnesium, thiosulfate) and the malate-aspartate shuttle that supports redox balance. It also includes regulation of mitochondrial membrane permeability and metabolic signaling related to fatty acids and insulin, highlighting a cohesive theme of mitochondrial transport/metabolism and redox control, despite some obsolete GO annotations present. ","confidence":"High","size":22,"edges":32,"triangles":11,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":7},{"id":"GO:0055114","count":6},{"id":"GO:0015709","count":6},{"id":"GO:0097274","count":6},{"id":"GO:0048250","count":6}]},{"hash":"1712622985694684657","title":"Neuronal axon guidance and synapse formation","description":"The top GO terms largely point to neuronal development, with multiple entries for axon guidance (sympathetic neuron projection guidance, semaphorin-plexin signaling) and extension, chemorepulsion in neuron migration, as well as synapse organization and assembly and adhesion processes. This combination suggests proteins focused on guiding neuronal projections and establishing synaptic contacts, rather than general cell metabolism or signaling. Therefore, the label reflects the cluster\u2019s core function.","confidence":"High","size":22,"edges":9,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0097491","count":8},{"id":"GO:0050808","count":8},{"id":"GO:0007157","count":8},{"id":"GO:1902287","count":8},{"id":"GO:0097490","count":8}]},{"hash":"1796429035718473344","title":"Mitotic cell cycle and ubiquitin regulation","description":"The most frequent terms point to cell division, mitotic cell cycle, and metaphase/anaphase transition, indicating a mitotic focus. There is also enrichment for ubiquitin-related processes (K11-linked ubiquitination) and protein oligomerization, consistent with regulation of mitosis by ubiquitin-mediated turnover and complex formation. Some terms (cadmium response, cytokinin signaling, prostate development) may reflect broader or context-specific annotations, but the core theme is mitosis with ubiquitin signaling.","confidence":"Medium","size":22,"edges":7,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":11},{"id":"GO:0071276","count":9},{"id":"GO:0000278","count":8},{"id":"GO:0051291","count":8},{"id":"GO:0070979","count":8}]},{"hash":"507496397347780074","title":"Drosophila Development and Morphogenesis","description":"The top terms indicate insect-specific development and morphogenesis processes (posterior head segmentation, oskar mRNA translation, epithelial migration, salivary gland morphogenesis, BMP signaling) with links to cell adhesion and apoptosis, suggesting a cluster of proteins involved in Drosophila developmental patterning and morphogenesis, including programmed cell death.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902108","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0007427","count":2},{"id":"GO:0035289","count":2},{"id":"GO:0046011","count":2}]},{"hash":"1271910703992534616","title":"Ubiquitin-mediated innate antiviral signaling","description":"The top GO terms point to innate immune response and defense against viruses, heavily tied to ubiquitin biology (ubiquitin-dependent and K63-linked polyubiquitination) and signaling pathways (NOD2) with additional immune modulation (vitamin D response). This suggests a cohesive cluster of proteins functioning in antiviral innate immunity through ubiquitin signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":10},{"id":"GO:0042787","count":10},{"id":"GO:0051607","count":8},{"id":"GO:0070534","count":8},{"id":"GO:0000083","count":7}]},{"hash":"1127704787017624811","title":"DNA replication and cell cycle processes","description":"The cluster shows strong representation of DNA replication, DNA integration, cell division, and mitotic cell cycle terms, pointing to core DNA metabolism and cell cycle regulation. While there are some viral-interaction terms (proviral latency, viral entry into the nucleus), the dominant signals are DNA replication and cell cycle-related processes, with ribosome biogenesis/export appearing as additional, less central processes. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1032003220755407363","title":"Ribosome Biogenesis and rRNA Processing","description":"Based on the GO terms, the cluster is centered on ribosome assembly and rRNA maturation (ribosome biogenesis, LSU biogenesis, maturation of LSU and 5.8S rRNA). There is also a link to cell cycle processes, suggesting coordination with proliferation, but the dominant theme is ribosome production and rRNA processing.","confidence":"High","size":22,"edges":181,"triangles":744,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":9},{"id":"GO:0051301","count":7},{"id":"GO:0042273","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0000463","count":5}]},{"hash":"1232006295071484607","title":"ER-Golgi Vesicle Trafficking","description":"The dominant GO terms are about ER to Golgi vesicle transport, COPII vesicle coating, and intracellular transport, indicating a cluster enriched for vesicle trafficking proteins. While there are also terms tied to small GTPase signaling and development, the trafficking theme is the strongest signal across the cluster.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007224","count":3},{"id":"GO:0001822","count":3}]},{"hash":"1165278379727511100","title":"Neural, Eye, and Lung Morphogenesis with Transcriptional Regulation","description":"Top GO terms center on transcriptional regulation by RNA polymerase II and neural/eye/lung morphogenesis (midbrain development, cerebral cortex interneuron differentiation, subpallium fate, eye and bronchiole development). This points to a set of proteins that regulate gene expression during development across neural and sensory organ tissues, including the lung. Therefore, this label captures the shared function. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0006366","count":13},{"id":"GO:0060441","count":12},{"id":"GO:0030901","count":12},{"id":"GO:0043010","count":12}]},{"hash":"1352540194276465784","title":"Embryonic morphogenesis and organogenesis","description":"The top GO terms cluster around vertebrate development and tissue formation, including cartilage morphogenesis, left\u2013right pattern formation, heart/endocardial cushion EMT, placenta/trophoblast differentiation, endocrine system development, and pancreatic beta cell development. Together these point to coordinated embryonic morphogenesis and organogenesis, with some general cellular processes likely representing background activity. Confidence in this label being representative is high.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":12},{"id":"GO:0060707","count":12},{"id":"GO:0035270","count":12},{"id":"GO:0003323","count":12},{"id":"GO:0060806","count":12}]},{"hash":"416865302051790186","title":"Extrinsic apoptosis signaling and inflammatory regulation","description":"This cluster is dominated by GO terms related to extrinsic apoptotic signaling (death receptor pathways) and regulation of apoptosis (positive/negative), complemented by inflammatory signaling (acute inflammatory response, NF-kappaB regulation). These together point to a cohesive theme of apoptosis control in an inflammatory context, even though a few terms touch on broader processes like centrosome duplication and proteoglycan metabolism.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":3},{"id":"GO:1902043","count":2},{"id":"GO:0032088","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0045671","count":2}]},{"hash":"1612148064859823369","title":"Rho/Ras GTPase signaling and actin cytoskeleton organization","description":"Top GO terms indicate a cluster centered on small GTPase signaling (Rho/Ras) and actin cytoskeleton dynamics, with accompanying links to related trafficking (Golgi localization). The dominant terms point to GTPase-mediated regulation of the cytoskeleton, while unrelated terms like vocalization or sound perception likely reflect annotation noise. Overall, the cluster appears to represent GTPase-driven signaling coordinating cytoskeletal organization and vesicle trafficking.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0071625","count":2},{"id":"GO:2000009","count":2}]},{"hash":"1061617356839533895","title":"NOD1/2 and GPCR Innate Immune Signaling","description":"The listed terms point to innate immune signaling pathways, including NOD1/2 signaling and GPCR-linked pathways, with defense responses to Gram-positive bacteria and NF-kB regulation (e.g., negative regulation of NF-kappaB), plus related cytokine regulation (IL-12). This suggests a cohesive theme around innate immune signaling rather than a single metabolic or cell-cycle process, despite some unrelated terms and zero edge connections. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:0032088","count":6},{"id":"GO:0070431","count":6},{"id":"GO:0016049","count":5},{"id":"GO:0007568","count":4}]},{"hash":"937390280370880189","title":"Dopamine/Adrenergic GPCR Signaling Hub","description":"This cluster centers on GPCR signaling pathways driven by dopamine and adrenergic receptors, including activation of adenylate cyclase (cAMP) and phospholipase C leading to PLC/IP3 signaling. The presence of terms for GTPase regulation, phototransduction, and heart development suggests activity in neural/retinal and cardiac contexts, with roles in pain regulation and chemokine production modulation. The core theme is dopamine/adrenergic receptor\u2013mediated signaling affecting cAMP and PLC pathways across diverse tissues.","confidence":"High","size":21,"edges":146,"triangles":531,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":20},{"id":"GO:0007603","count":20},{"id":"GO:0043950","count":20},{"id":"GO:0007191","count":20},{"id":"GO:0007507","count":20}]},{"hash":"1821945011884536756","title":"Unknown","description":"The cluster combines GO terms across development (lung development; Schwann cell development; epithelial-to-mesenchymal transition), immune cell movement (B cell chemotaxis), signaling (integrin activation and integrin-mediated signaling), metabolism (lipid A biosynthetic process), response to a chemical (response to cocaine), and core cell-cycle processes (DNA replication; meiotic cell cycle). Because these terms cover disparate biological themes with no clear, common function, there isn\u2019t a single unifying label that accurately represents the cluster.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030324","count":4},{"id":"GO:0035754","count":4},{"id":"GO:0009245","count":3},{"id":"GO:0033622","count":3},{"id":"GO:0007229","count":3}]},{"hash":"1254692597233668749","title":"Xenobiotic and lipid metabolism","description":"The cluster is enriched for metabolic and catabolic processes including prostaglandin biosynthesis, cholesterol and alkaloid metabolism, and insecticide/dioxin-related catabolic processes, pointing to detoxification and lipid mediator-related metabolism as a common theme. A few terms (e.g., prostate gland growth) are less connected and may reflect annotation noise, but overall the proteins appear tied to processing diverse xenobiotics and lipids. ","confidence":"Medium","size":21,"edges":10,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":13},{"id":"GO:0060736","count":12},{"id":"GO:0017143","count":12},{"id":"GO:0033076","count":12},{"id":"GO:0019341","count":12}]},{"hash":"1895194695800185116","title":"Neuroimmune signaling modulators","description":"The top GO terms cluster around modulation of neural signaling (pain perception, acetylcholine metabolism, dopamine signaling, glutamatergic transmission) and immune/inflammatory outputs (interleukin/chemokine production, histamine signaling). The presence of blood pressure regulation and photoreceptor maintenance suggests broader neuromodulatory roles across sensory and autonomic systems, consistent with proteins that couple neural signaling to immune/inflammatory regulation. High","confidence":"","size":21,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":19},{"id":"GO:0090198","count":19},{"id":"GO:0060408","count":19},{"id":"GO:2000484","count":19},{"id":"GO:0032651","count":19}]},{"hash":"2102299579826269090","title":"Unknown","description":"This cluster\u2019s GO terms span host-symbiont dormancy, stress response, various metabolic and biosynthetic processes (menaquinone, raffinose family oligosaccharides, tRNA thiolation), and some neuronal/APP-related processes. There is no clear, cohesive functional theme linking these terms, making a single representative label inappropriate. Confidence: None","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":11},{"id":"GO:0006950","count":11},{"id":"GO:0009234","count":2},{"id":"GO:0002143","count":2},{"id":"GO:0010325","count":2}]},{"hash":"2220667483563923384","title":"Innervation and neuromuscular regulation","description":"The terms show a clear emphasis on neural innervation and neuromuscular regulation (innervation; neuromuscular process controlling posture), suggesting these proteins participate in neural signaling and muscle control. Other enriched terms cover transcriptional and metabolic processes (lipid metabolism, quinolinate biosynthesis, response to vitamin B6), indicating additional roles in general cellular metabolism and regulation. Taken together, the cluster is best described by neural innervation and neuromuscular control with secondary metabolic/regulatory functions.","confidence":"Medium","size":21,"edges":30,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0050884","count":3},{"id":"GO:0060384","count":3},{"id":"GO:0048146","count":2},{"id":"GO:0046325","count":2}]},{"hash":"643179442704880547","title":"Signaling Pathways and Cell Cycle Control","description":"The cluster includes GO terms centered on major signaling cascades (TNF-mediated signaling, non-canonical NF-kappaB, and Wnt PCP) alongside cell-cycle related processes (cell division and ubiquitin ligase regulation of mitosis). Additional terms touch cytoskeletal organization (muscle thin filament assembly) and stress responses (salt stress), with some peripheral references to viral processes and gamete generation. Taken together, the proteins appear to participate in signaling-driven regulation of division, development, and cytoskeletal dynamics.","confidence":"Medium","size":21,"edges":70,"triangles":120,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0010950","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0007292","count":3},{"id":"GO:0071689","count":3},{"id":"GO:0016032","count":3}]},{"hash":"395481148085099718","title":"Heart development and endothelial migration","description":"The top GO terms cluster around cardiovascular development and morphogenesis, including dorsal aorta morphogenesis, endocardial cushion formation, and cardiac neural crest\u2013driven outflow tract morphogenesis, with several terms about endothelial cell movement and angiogenesis regulation; while there are related lipid transport and redox terms, the dominant theme ties to heart/vascular development and endothelial remodeling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0098869","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0035912","count":4},{"id":"GO:0003273","count":4},{"id":"GO:0090051","count":3}]},{"hash":"1682636243147626508","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":67,"triangles":59,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0050427","count":9},{"id":"GO:0042403","count":9},{"id":"GO:0030573","count":9},{"id":"GO:0048702","count":9},{"id":"GO:0018146","count":9}]},{"hash":"235188414010480043","title":"GPCR-cAMP Signaling and Growth Regulation","description":"The most represented terms are adenylate cyclase activation and GPCR signaling (GO:0007190, GO:0010579), alongside positive regulation of cell population proliferation and blood pressure. This indicates a cohesive theme of GPCR-driven cAMP pathways that modulate cell growth and vascular signaling. While there are a few outliers (retina development, immune regulation), the core shared function is GPCR-cAMP\u2013mediated signal transduction that influences proliferation.","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":19},{"id":"GO:0008284","count":19},{"id":"GO:0043547","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0007190","count":19}]},{"hash":"1950906661181773781","title":"Mitotic and Synaptic Signaling Regulators","description":"This cluster combines terms tied to synaptic organization (postsynaptic density assembly, regulation of synaptic vesicle clustering) with mitotic and cytoskeletal processes (kinetochore/spindle localization, actomyosin ring maturation, cytokinesis, and related signaling like ERK and JAK-STAT). The proteins appear to modulate signaling pathways and cytoskeletal dynamics in both neuronal and cell division contexts, suggesting a role as regulators of signaling and cytoskeletal organization across contexts.","confidence":"Medium","size":21,"edges":20,"triangles":0,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0097107","count":2},{"id":"GO:0051895","count":2},{"id":"GO:0039563","count":1},{"id":"GO:0044878","count":1},{"id":"GO:2000808","count":1}]},{"hash":"1784010288921200395","title":"Angiogenesis and axon guidance in development","description":"The top GO terms cluster around developmental guidance and morphogenesis: coronary artery morphogenesis; cell migration in sprouting angiogenesis; axon extension during axon guidance; and negative regulation of Notch signaling. Together, these point to a theme of coordinated signaling and migration during vascular and neural development. Some terms (proteolysis, hydroxylation, antibiotic biosynthesis, etc.) are more peripheral or potentially due to broad protein functions or annotation noise, but the core terms support the angiogenesis/axon guidance theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006508","count":3},{"id":"GO:0045746","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0048846","count":3}]},{"hash":"1312853289828682955","title":"Retinoid and Ethanol Metabolism","description":"Based on the top GO terms, the proteins cluster around retinol and retinoic acid metabolic processes, together with ethanol catabolic/oxidation pathways and related redox processes. This points to a core theme of vitamin A metabolism linked to alcohol processing, with ancillary signals like LPS response and blood pressure regulation likely reflecting broader metabolic context rather than a distinct separate function.","confidence":"High","size":21,"edges":192,"triangles":1141,"max_degree":20,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042572","count":16},{"id":"GO:0046370","count":14},{"id":"GO:0006068","count":10},{"id":"GO:0006069","count":10},{"id":"GO:0055114","count":10}]},{"hash":"543807792944262804","title":"ER Protein Folding and Oxidative Stress Response","description":"The cluster is dominated by ER-related quality control and stress signaling: protein folding in the endoplasmic reticulum, unfolded protein response, and translation regulation in response to ER stress, along with multiple redox/oxidative stress terms. This suggests a cohesive program of managing protein-folding load in the ER and maintaining redox homeostasis under stress, with accompanying transcriptional changes. ","confidence":"High","size":21,"edges":68,"triangles":88,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034975","count":15},{"id":"GO:0045454","count":15},{"id":"GO:0070389","count":12},{"id":"GO:0006351","count":11},{"id":"GO:0036494","count":11}]},{"hash":"987080998121916011","title":"Neural signaling and sensory perception","description":"Predominantly neural signaling and sensory processing features: visual perception/learning, dopaminergic synaptic transmission, pain perception, and cocaine-related behavioral responses, all linked by ERK1/2 signaling. Heart development and coagulation terms are present but not core.","confidence":"Medium","size":21,"edges":27,"triangles":4,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":7},{"id":"GO:0007507","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0001963","count":5},{"id":"GO:0071380","count":5}]},{"hash":"764011075775355015","title":"Cell Signaling and Metabolic Regulation","description":"Genes in this cluster show a mix of signaling-related functions (activation of protein kinases, nitric-oxide synthase regulation, response to amphetamine) alongside metabolic and developmental processes (ribosome biogenesis, folic acid metabolism, heart and kidney development), plus oxidative stress regulation and proteolysis. This suggests a broad regulatory/signaling theme with metabolic and developmental links, rather than a single cohesive pathway, supporting a label focused on signaling and metabolic regulation rather than a narrow function.","confidence":"Medium","size":21,"edges":20,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051000","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0032147","count":2},{"id":"GO:0055010","count":2}]},{"hash":"1886987533363363506","title":"Neuronal development and trafficking","description":"This cluster centers on neural development and synaptic/function-related processes (substantia nigra development, excitatory postsynaptic potential) and intracellular processing/trafficking (ER-Golgi transport, cilium assembly, mRNA splicing, serine dephosphorylation), with supporting metabolic transport terms (galactose, sialic acid, vitamins). The combination suggests a theme around neuron-specific development, signaling, and protein trafficking.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021762","count":2},{"id":"GO:0070262","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0035690","count":2}]},{"hash":"1830765861182139851","title":"Signaling Regulation and Proliferation","description":"The proteins cluster around modulation of signaling pathways (Rho, GTPases, Wnt, GPCR) and post-translational control (ubiquitination, autophosphorylation), with downstream effects that touch on endocytosis, hypoxia response, proliferation, and cardiac-related processes. This points to a theme of broad regulation of cell signaling and growth rather than a single pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0048549","count":6},{"id":"GO:0035023","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0016055","count":5}]},{"hash":"1687652044700874321","title":"Chromatin regulation and transcriptional control","description":"The cluster\u2019s top GO terms cluster around chromatin dynamics and transcriptional regulation, including histone H3 acetylation, heterochromatin formation, regulation of transcription by RNA polymerases I and II, and chromatin localization. Additional terms on sister chromatid cohesion maintenance and nucleolar transcription adjustments underscore a shared role in establishing and maintaining chromatin state while coordinating transcription. This cohesive theme supports labeling as chromatin regulation and transcriptional control.","confidence":"High","size":21,"edges":63,"triangles":95,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":7},{"id":"GO:0030466","count":7},{"id":"GO:1901837","count":6},{"id":"GO:0061086","count":6},{"id":"GO:0034184","count":6}]},{"hash":"2062642752269518126","title":"TLR signaling and macrophage activation","description":"This cluster is dominated by GO terms tied to innate immunity and Toll-like receptor pathways (innate immune response, defense against viruses and Gram-negative bacteria, MyD88-independent TLR signaling, TLR8 signaling, macrophage activation, inflammatory regulation). Together, these point to proteins involved in TLR-mediated sensing and resultant macrophage-driven inflammatory responses. The chloroquine response and xenobiotic transport terms suggest additional endosomal/transport context that can modulate TLR signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0006855","count":3},{"id":"GO:0002756","count":3},{"id":"GO:0042116","count":3}]},{"hash":"1528159154176779709","title":"Neural signaling and sensory processing","description":"The cluster\u2019s top GO terms converge on neuronal signaling and sensory function: sodium and potassium ion transport across membranes, regulation of glutamatergic synaptic transmission, prepulse inhibition, pain perception, and learning/response to psychoactive drugs. While there is an outlier term related to cell wall macromolecule catabolic process, the dominant signals point to neural excitability and sensory processing roles.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060134","count":5},{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0051930","count":4},{"id":"GO:0051967","count":4}]},{"hash":"1422143714001931275","title":"Telomere maintenance regulation","description":"Most top GO terms cluster around telomere biology, including regulation of telomere maintenance via telomerase, telomere capping, and localization to the telomeric region, as well as negative regulation of telomere maintenance and chromatid cohesion at telomeres. This coherence suggests the proteins in this cluster collectively participate in preserving telomere integrity and proper chromosome end maintenance. While there are a few terms related to PARP-mediated ADP-ribosylation, SNARE regulation, actin bundle assembly, and neuronal differentiation, these are less central to the core telomere-focused theme. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904908","count":5},{"id":"GO:0070212","count":5},{"id":"GO:0035544","count":5},{"id":"GO:0032212","count":5},{"id":"GO:1904357","count":5}]},{"hash":"149216709850041851","title":"Neuronal development and axonogenesis","description":"Many top terms point to neural development, axon guidance, and synapse formation (axonogenesis, axonal fasciculation, synapse assembly, corpus callosum development), complemented by sensory perception of touch/pain and ion channel\u2013related processes. This suggests the proteins function together in nervous system development and neuronal signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050976","count":3},{"id":"GO:0098914","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0051965","count":3}]},{"hash":"224503747215054519","title":"Axon Guidance and Nerve Patterning","description":"The top GO terms are dominated by neural development and axon navigation, including facial and trigeminal nerve organization, branchiomotor neuron axon guidance, and semaphorin-plexin signaling, plus regulation of axon extension. Although a few terms touch on unrelated processes (stress granules, immune signaling), the core cluster points to neural patterning and pathfinding.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021612","count":2},{"id":"GO:1902287","count":2},{"id":"GO:0021637","count":2},{"id":"GO:0060666","count":2},{"id":"GO:0048843","count":2}]},{"hash":"2242010518386223845","title":"Unknown","description":"The top GO terms cover heart development, blood coagulation, immune and xenobiotic responses, sensory perception of sound, and germ cell death, showing no single shared function or pathway for the cluster.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0032496","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0007596","count":2}]},{"hash":"954462124678604227","title":"Neural development and synaptic organization","description":"This cluster heavily features neural-focused terms: positive regulation of synapse assembly, synapse organization, transmission of nerve impulse, and myelination, which together point to neural development and synaptic function. While there are also broad developmental terms (BMP signaling, heart and kidney development) and a muscle-related assembly term, the core signal is neural development and synaptic connectivity.","confidence":"High","size":21,"edges":146,"triangles":464,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":10},{"id":"GO:0001822","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0030513","count":9},{"id":"GO:0019226","count":8}]},{"hash":"52021903307791558","title":"Virus-host replication and budding factors","description":"The top GO terms are strongly centered on viral life-cycle steps, including virion assembly, viral budding via the ESCRT pathway, DNA integration, and establishment of proviral latency, which point to roles in virus replication and virus-host interactions. While other terms like splicing, translation, and cell-cycle processes appear as general cellular functions that viruses exploit, the viral-related terms collectively define a coherent theme for this cluster.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0007064","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0001649","count":3}]},{"hash":"1555073228603030762","title":"Neural development and axon guidance signaling","description":"Based on the top GO terms, the cluster is dominated by neural development and axon guidance signals (axon guidance, Roundabout pathway, nervous system development, SHH/SMO signaling, ERK cascade regulation, and related pathways). While there are a few terms pointing to broader organogenesis (kidney development, ossification), the strongest theme is developmental signaling linked to neural patterning and axon navigation. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007411","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0070374","count":4}]},{"hash":"2287294897126318686","title":"TLR-MyD88 NF-kappaB inflammatory signaling","description":"This cluster is dominated by innate immune signaling and inflammation, centered on TLR4/MyD88-NF-\u03baB pathways and downstream cascades (IL-17 production, JNK), with additional notes on immunoglobulin-mediated responses. The shared GO terms indicate activation of NF-\u03baB signaling and inflammatory responses.","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032740","count":6},{"id":"GO:0051092","count":6},{"id":"GO:0006954","count":6},{"id":"GO:0043123","count":6},{"id":"GO:0071260","count":6}]},{"hash":"1859581136516865494","title":"Neuronal innate immune signaling and development","description":"The top GO terms span innate immune responses to bacterial components (LPS, Gram-positive defense) and neural development processes (axonogenesis, synapse assembly, dopamine-related signaling), plus mitochondrial fission and nuclear export regulation. This combination suggests a coherent theme of neuroimmune signaling intertwined with neuronal development and synaptic maturation, rather than a single isolated pathway.","confidence":"Medium","size":21,"edges":35,"triangles":21,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046827","count":7},{"id":"GO:0045087","count":6},{"id":"GO:0031663","count":6},{"id":"GO:0071222","count":6},{"id":"GO:0090141","count":5}]},{"hash":"809258441500426504","title":"Unknown","description":"The top terms span diverse processes\u2014ion transport, transcription, GPCR signaling, GTPase and Rho regulation, nucleocytoplasmic transport, proteasomal degradation, immune defense, and general cellular regulation\u2014without a single unifying function, so a coherent cluster label cannot be confidently assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0035264","count":2},{"id":"GO:0007200","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006409","count":2}]},{"hash":"864299252662711385","title":"Plant stress signaling and amino acid metabolism","description":"The top GO terms center on plant-relevant processes such as abscisic acid response, proline transport, and amino acid biosynthesis/salvage, with supporting hints from protein ubiquitination and phosphorylation that point to regulatory signaling. Although there are some outliers (e.g., pancreatic cell development) that may be annotation noise, the dominant signals suggest a theme of plant stress responses and amino acid metabolism.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0009737","count":2},{"id":"GO:0015824","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0016310","count":2}]},{"hash":"2067574330164058848","title":"GPCR Signaling and Receptor Regulation","description":"The top GO terms cluster around G protein-coupled receptor (GPCR) signaling, including the signaling pathway, receptor internalization, desensitization, and intracellular signal transduction. Additional terms touch on GPCR-dependent processes in heart and eye (cardiac muscle contraction, heart development, and visual perception), suggesting a common theme of GPCR-mediated signaling and regulation across tissues.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032733","count":3},{"id":"GO:0032715","count":3},{"id":"GO:0060048","count":2},{"id":"GO:0007217","count":2},{"id":"GO:0007507","count":2}]},{"hash":"641243372937133445","title":"Viral DNA integration and replication","description":"The top GO terms cluster around viral processes and DNA metabolism: DNA integration, DNA replication, and DNA biosynthetic processes, along with proviral latency and viral entry into the host nucleus. These collectively suggest functions related to viral infection cycles that involve integration and replication of viral DNA within host cells, hence the label focusing on viral DNA integration and replication.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0035269","count":2},{"id":"GO:0060049","count":2},{"id":"GO:0046329","count":2},{"id":"GO:0075713","count":2}]},{"hash":"282373010554460076","title":"Embryogenesis and Growth Factor Production","description":"These terms point to roles in early development (zygotic axis formation and embryonic organ development) and in production or regulation of signaling molecules (nerve growth factor, cytokines, TGF-beta). The combination suggests a cluster of proteins involved in embryogenesis with secreted signaling functions rather than a single cohesive pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007354","count":2},{"id":"GO:0048566","count":2},{"id":"GO:0035187","count":2},{"id":"GO:0061096","count":2},{"id":"GO:0016540","count":2}]},{"hash":"1455805061790150612","title":"SA node signaling and cardiac mechanotransduction","description":"The top GO terms point to cardiac electrical signaling (regulation of SA node cell action potential and SA node cell to atrial cardiac muscle cell communication) and mechanosensitive responses (cellular response to mechanical stimulus, response to muscle stretch), supporting a theme of heart-specific signaling and mechanotransduction. While several immune-related terms and general processes appear, they are less central than the cardiac terms, suggesting the cluster mainly reflects pacemaker activity and mechanotransduction in cardiac tissue.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045083","count":3},{"id":"GO:0002268","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0006397","count":3}]},{"hash":"1321380368862724396","title":"Lipid Biosynthesis and Immune Signaling","description":"The GO terms show a strong emphasis on lipid metabolism and remodeling (triglyceride biosynthesis, cardiolipin remodeling, CDP-diacylglycerol biosynthesis, ether lipids, platelet activating factor biosynthesis, phosphatidylcholine regulation), suggesting lipids as the core function. A subset indicates immune-related activity (interleukin-2 production, negative regulation of activation-induced T cell death), implying possible signaling roles of lipids in immune processes. Some terms (cutin biosynthesis, cerebellum morphogenesis) appear incidental and less central. Overall, a cohesive lipid biosynthesis theme with a potential immune-signaling component.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":3},{"id":"GO:0070970","count":3},{"id":"GO:0070236","count":3},{"id":"GO:0035965","count":3},{"id":"GO:0010143","count":3}]},{"hash":"1607575240114583438","title":"NF-kappaB-regulated neuronal signaling and CNS development","description":"Top terms show NF-kappaB pathway regulation as the core signal, with several terms linking to neuronal signaling and CNS development (synaptic plasticity, ephrin signaling, Rho signaling). Golgi localization and angiogenesis appear but are less central. Overall, these proteins likely participate in NF-kappaB\u2013regulated neuronal signaling and CNS development processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0043123","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0035023","count":3}]},{"hash":"1605871148923563631","title":"Embryonic organogenesis and differentiation","description":"The most frequent GO terms converge on differentiation and development across multiple tissues and organs (trophoblast, heart, placenta, cartilage, endocrine and pancreatic development), suggesting a broad role in embryonic organogenesis rather than a single specific pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0035002","count":2},{"id":"GO:0060665","count":2}]},{"hash":"1375144560905846601","title":"Unknown","description":"The top GO terms span translation initiation, intracellular transport, cytoskeletal remodeling, lipid biosynthesis, protein deneddylation, and development-related processes, with no single cohesive function linking them. The terms are too heterogeneous to define a specific, shared biological role for this cluster.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033137","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0051014","count":2},{"id":"GO:0006646","count":2}]},{"hash":"914840819542506756","title":"Biosynthesis and RNA Modification","description":"The top GO terms indicate strong involvement in metabolic biosynthetic processes (antibiotic, biotin, ubiquinone biosynthesis) along with RNA-centric modifications (tRNA wobble uridine modification, RNA guanine-N7-methylation) and related RNA processing (ribosomal subunit export). While some stress-related terms are present, the dominant signal is metabolic biosynthesis paired with RNA modification, justifying this combined name.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":9},{"id":"GO:0017000","count":9},{"id":"GO:0009102","count":9},{"id":"GO:0042220","count":8},{"id":"GO:0002098","count":8}]},{"hash":"1327679565698005644","title":"Neural development and signaling","description":"The cluster centers on neural development and function, with GO terms covering neurogenesis, forebrain migration, myelination, nerve impulse transmission, synaptic plasticity, Hedgehog/Smoothened signaling, angiogenesis related to CNS development, and even behavior. A cohesive theme is neural differentiation and maturation coupled with neuronal signaling processes, so \u201cNeural development and signaling\u201d is representative. ","confidence":"High","size":20,"edges":130,"triangles":545,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0022008","count":11},{"id":"GO:0006915","count":11},{"id":"GO:0019226","count":9},{"id":"GO:0044708","count":9},{"id":"GO:0007169","count":9}]},{"hash":"2085922381434901502","title":"Transmembrane Transporters","description":"Explanation: The top GO terms are dominated by transmembrane transport activities across membranes, covering ions (sodium, potassium), vitamins, sugars (galactose), sialic acid, nitrite/nitrate, xenobiotics, and neurotransmitter loading into synaptic vesicles. This points to a cluster of membrane transporter proteins rather than enzymes or receptors, justifying the label \"Transmembrane Transporters.\"","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035725","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0035461","count":8},{"id":"GO:0015757","count":8},{"id":"GO:0015739","count":8}]},{"hash":"2018492875507513872","title":"Microtubule Cytoskeleton Dynamics and Polarity","description":"These proteins cluster around microtubule-based processes: cytokinesis via cell plate formation, establishment/maintenance of microtubule cytoskeleton polarity, minus-end directed microtubule sliding, mitotic centrosome separation, meiotic spindle orientation, and anterograde dendritic transport of receptor complexes, with additional involvement in zonula adherens maintenance. The presence of neuron-related organization terms alongside division-related terms suggests a common theme of microtubule-regulated organization and transport across cell types. ","confidence":"High","size":20,"edges":78,"triangles":171,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000911","count":20},{"id":"GO:0021693","count":20},{"id":"GO:0036334","count":20},{"id":"GO:0030951","count":20},{"id":"GO:0031534","count":20}]},{"hash":"815940960166612474","title":"Glycosylation- and cell-surface polysaccharide biosynthesis","description":"The cluster\u2019s GO terms strongly center on glycan biosynthesis and modification (arabinogalactan protein metabolism, mucilage biosynthesis, O-linked glycosylation via hydroxyproline, poly-N-acetyllactosamine, and Lewis a epitope biosynthesis) and on cell-surface/cell-polarity processes (maintenance of polarity of follicular epithelium, adhesion), with some terms related to infection structure formation. This points to a unifying theme of glycosylation-dependent cell-surface interactions across different contexts, making a glycosylation- and surface-polysaccharide biosynthesis label appropriate. Confidence: Medium","confidence":"","size":20,"edges":37,"triangles":10,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0010405","count":5},{"id":"GO:0001744","count":5},{"id":"GO:0007299","count":5},{"id":"GO:0048354","count":5}]},{"hash":"2185893958184223353","title":"Metal Ion Transport and Homeostasis","description":"The strongest signals are zinc ion transmembrane transport, copper ion transport, and intracellular calcium ion homeostasis, pointing to a core role in metal ion handling across membranes. Other terms show diverse metabolic activities (lipopolysaccharide biosynthesis, epoxygenase P450 pathway, stilbene catabolism) and DNA integration, but the metal transport/homeostasis theme is the clearest through-line for this cluster.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0071577","count":2},{"id":"GO:0006564","count":2},{"id":"GO:0006825","count":2},{"id":"GO:0006874","count":2}]},{"hash":"1211538027843380685","title":"Brain development and cranial morphogenesis","description":"Top terms cluster around nervous system and brain-region development (trigeminal ganglion, midbrain, cerebellum, forebrain morphogenesis, telencephalon regionalization, locus ceruleus) and cranial skeletal morphogenesis, implying a cohesive neural/cranial development theme with possible transcriptional regulation during these processes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0061551","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0021549","count":6},{"id":"GO:0002087","count":6}]},{"hash":"1233370624172376461","title":"Calcium signaling in cardiac development","description":"The cluster shows enrichment for terms tied to calcium dynamics and signaling, including regulation of calcium release into the cytosol and ryanodine receptor activity, along with related signaling processes such as GTPase regulation, protein phosphorylation, and adenylate cyclase activation, plus explicit heart development. This combination suggests a coherent theme of calcium-dependent signaling pathways that influence cardiac development, despite a few broader or obsolete terms not altering the core pattern. Confidence is Medium.","confidence":"","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0043547","count":2}]},{"hash":"695607028446647878","title":"DNA replication and telomere maintenance","description":"The terms cluster around DNA replication and genome stability, including DNA unwinding, replication fork dynamics (fork reversal), RNA primer processing, DNA strand elongation, recombination, and telomere maintenance (with supporting mitochondrial genome maintenance and repair terms). This suggests a cohesive set of proteins involved in replication machinery and telomere upkeep, with some mitochondrial genome maintenance connections.","confidence":"High","size":20,"edges":184,"triangles":1039,"max_degree":19,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032508","count":11},{"id":"GO:0044806","count":9},{"id":"GO:0071932","count":9},{"id":"GO:0000723","count":9},{"id":"GO:0000002","count":9}]},{"hash":"939243347295600539","title":"Steroid Hormone Signaling and Male Development","description":"The cluster is defined by strong signals for steroid hormone signaling and male reproductive development: prostate gland development, male sex differentiation, and steroid hormone receptor complex assembly, suggesting a hormonal-regulatory function. Some outlier terms (unfolded protein response, chaperone-related regulation, interferon response) reduce cohesiveness, so the overall theme is present but not exclusively cohesive. ","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0030850","count":8},{"id":"GO:0071357","count":8},{"id":"GO:0046661","count":8},{"id":"GO:0006463","count":8},{"id":"GO:1903646","count":8}]},{"hash":"933447612653283188","title":"Cytoplasmic translation machinery and ribosome assembly","description":"The top GO terms are dominated by translation- and ribosome-related processes: cytoplasmic translation, translation, translational initiation/termination, and ribosomal large subunit assembly, along with selenocysteine incorporation, indicating proteins involved in protein synthesis. The presence of deadenylation-dependent decay points to coupling with mRNA turnover and translation regulation. A couple of terms like glial cell proliferation and detoxification are less central and may reflect broader expression context or annotation noise. Overall, the cluster appears to group components of the translational machinery and its immediate mRNA processing context.","confidence":"High","size":20,"edges":38,"triangles":43,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0098869","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0002181","count":2}]},{"hash":"2108876418032439946","title":"Nuclear transcription, replication, and RNA processing","description":"The top GO terms point to core nuclear activities: positive regulation of transcription by RNA polymerase II, DNA replication and recombination, RNA exon ligation (splicing), and protein import into the nucleus. These converging terms suggest a cluster focused on nuclear gene expression and genome maintenance, with some ancillary terms reflecting broader developmental or stress-related aspects that are less central to the main theme.","confidence":"Medium","size":20,"edges":24,"triangles":1,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045944","count":7},{"id":"GO:0006310","count":6},{"id":"GO:0006260","count":5},{"id":"GO:0014070","count":5},{"id":"GO:0017038","count":4}]},{"hash":"155670874156246355","title":"Organ and Tissue Development","description":"The top GO terms point to development of multiple organs and tissues (retina, liver, skeletal muscle, roof of the mouth, trigeminal ganglion, etc.) and to multicellular organism development, suggesting a general theme of organ/tissue formation rather than a single specific pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":3},{"id":"GO:0006366","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0061551","count":3}]},{"hash":"1860199172584690786","title":"Neuroimmune signaling and glycosylation","description":"The top GO terms point to nervous system signaling (sensory perception of pain, neuropeptide signaling, temperature stimulus) together with immune modulation (immune response, regulatory T cell differentiation) and glycosylation-related processes (glycosylation and Lewis antigen biosynthesis). This pattern suggests a cohesive role in glycan-mediated neural-immune communication, even though some terms are obsolete and there are no direct edges. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0007218","count":2},{"id":"GO:0010961","count":2},{"id":"GO:0002024","count":2}]},{"hash":"118536133132924764","title":"Developmental signaling and immune pathways","description":"Based on the top GO terms, this cluster centers on developmental processes in multicellular organisms (heart development, multicellular organism development) and on signal transduction pathways (Fc-epsilon receptor signaling, GPCR-related signaling, GTPase activity regulation, NFAT/calcineurin signaling). An adaptive immune response term also appears, suggesting immune-related signaling. A few terms (mRNA processing, potassium channel clustering) are ancillary. Overall, the proteins seem to participate in signaling networks guiding development and immune responses, justifying the label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0032516","count":3}]},{"hash":"637344488110985481","title":"Innate immune and neural signaling","description":"The cluster shows enrichment for innate immune terms (innate immune response; defense against Gram-positive bacteria) alongside neural-related terms (positive regulation of synapse assembly; cellular response to dopamine) and migration/developmental processes (cell migration; heart development), suggesting a set of genes involved in signaling cross-talk between immune and nervous/developmental pathways.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0097011","count":3},{"id":"GO:2001275","count":3}]},{"hash":"2256762862623960624","title":"Cell Adhesion and Migration Signaling","description":"Top GO terms cluster around cell adhesion, extravasation, and integrin signaling, with links to T cell activation and developmental processes. This suggests a cohesive theme of adhesion- and migration-driven signaling, common to immune cell trafficking and tissue development, rather than a single narrow function.","confidence":"Medium","size":20,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070208","count":8},{"id":"GO:0045123","count":5},{"id":"GO:0034113","count":5},{"id":"GO:0035987","count":5},{"id":"GO:0002291","count":5}]},{"hash":"839613700593202337","title":"Coagulation and Innate Immune Signaling in Vascular Remodeling","description":"The top GO terms cluster around blood coagulation (blood coagulation; complement activation via the lectin pathway), innate immune signaling ( Toll pathway regulation) and vascular-associated remodeling (smooth muscle cell migration), with supporting terms related to tissue development. This suggests the proteins participate in coagulation/immune responses linked to vascular remodeling, rather than a single narrow function. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014909","count":4},{"id":"GO:0030194","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0031214","count":4}]},{"hash":"2214609537739373449","title":"Embryonic Development and Organogenesis Regulators","description":"These terms cluster around embryonic development and tissue morphogenesis across multiple organs (nervous system, pancreas, teeth, kidney, digestive tract, midbrain, etc.), with an additional note of transcriptional regulation. The consistent theme is regulation of developmental processes rather than a single cellular function, suggesting these proteins act as developmental regulators affecting organogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0048935","count":5},{"id":"GO:0090009","count":5},{"id":"GO:0045617","count":4},{"id":"GO:0048557","count":4}]},{"hash":"19429562058839627","title":"Embryonic Development and Morphogenesis","description":"The GO terms point to embryonic development and tissue morphogenesis, including cartilage morphogenesis, trophoblast giant cell differentiation, endocrine and pancreatic cell development, left-right patterning, and epithelial-to-mesenchymal transition in heart formation. A few housekeeping terms (ribosomal export, mRNA splicing) are present, but the dominant signal is developmental differentiation and morphogenesis.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":12},{"id":"GO:0060707","count":12},{"id":"GO:0035270","count":12},{"id":"GO:0003323","count":12},{"id":"GO:0060806","count":12}]},{"hash":"1914666400143198876","title":"Embryonic Tissue Morphogenesis","description":"The GO terms point to developmental and morphogenesis processes across multiple tissues (cartilage, placenta/t trophoblast, endocrine/pancreatic development, left-right patterning, endocardial cushion formation, hair follicles, palate), indicating a broad embryonic tissue morphogenesis theme rather than a single tissue-specific function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060806","count":3}]},{"hash":"1325412441704936072","title":"Differentiation and inflammatory signaling regulators","description":"The cluster\u2019s top GO terms emphasize immune/inflammatory regulation (NF-kappaB activity, IL-12 production, NOD1 signaling, MIP-1\u03b1 production) and protein ubiquitination, with additional terms related to differentiation of dendritic/neuronal lineages (granule cell, dendrite development, follicular dendritic cell differentiation). This points to a theme of regulatory processes coordinating differentiation with immune signaling, rather than a single metabolic or structural function. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0032088","count":7},{"id":"GO:0045083","count":6},{"id":"GO:0070427","count":6}]},{"hash":"1418408086821821598","title":"Neural crest migration and axon guidance","description":"The top terms point to neural crest\u2013derived development (ventral trunk neural crest cell migration) and neuronal guidance (sympathetic neuron projection guidance/extension, semaphorin-plexin signaling in axon guidance), with supporting roles for cell adhesion and ERK signaling. Heart development appears as a broader neural crest\u2013related context, but the dominant theme is neural crest migration paired with axon guidance.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0051260","count":2},{"id":"GO:0050860","count":2},{"id":"GO:0034499","count":2},{"id":"GO:0097491","count":2}]},{"hash":"1227109168762942603","title":"Embryonic patterning and tissue morphogenesis","description":"The top GO terms cluster around embryonic development processes, including left/right pattern formation, cartilage morphogenesis, trophoblast differentiation, endocrine and pancreatic development, and EMT related to heart/placenta formation, indicating a cohesive theme of embryonic tissue patterning and morphogenesis. A few other terms (immune response, synaptic plasticity) appear at low counts, likely incidental.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0060536","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003323","count":5}]},{"hash":"372648718573876802","title":"Vertebrate embryonic organogenesis and neural patterning","description":"The cluster centers on transcription by RNA polymerase II and a spectrum of embryonic development processes, especially neural development (spinal cord neuron differentiation, cerebral cortex regionalization, forebrain-midbrain boundary formation) alongside organogenesis (pancreas, pituitary, ureteric bud branching, cranial skeleton). This suggests a theme of transcriptionally coordinated developmental patterning across multiple tissues.","confidence":"Medium","size":19,"edges":120,"triangles":338,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0048701","count":8},{"id":"GO:0031016","count":8},{"id":"GO:0021912","count":7},{"id":"GO:2000288","count":7}]},{"hash":"1526608660455604401","title":"Developmental signaling and cytoskeletal remodeling","description":"The top GO terms cluster around developmental processes (multicellular growth, gastrulation, oligodendrocyte differentiation) and signaling pathways (TGF-beta response, mitochondria-nucleus signaling), with components of cytoskeletal remodeling (actin depolymerization). This suggests a theme of developmental growth and differentiation tied to signaling and cytoskeletal dynamics.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0048709","count":3},{"id":"GO:0001403","count":2},{"id":"GO:0031954","count":2}]},{"hash":"850752910070729960","title":"DNA Replication and Genome Maintenance","description":"The top GO terms cluster around DNA replication, primer synthesis, DNA unwinding, topological changes, recombination, and SOS response, indicating a cohesive module of replication and genome maintenance machinery. A few terms related to RNA processing and morphogenesis appear as less representative noise.","confidence":"High","size":19,"edges":21,"triangles":5,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0009432","count":9},{"id":"GO:0006268","count":9},{"id":"GO:0006265","count":9},{"id":"GO:0000184","count":9}]},{"hash":"1223131957830657609","title":"Mitochondrial Transport and Metabolism","description":"The top GO terms cluster around mitochondrial metabolite transport and energy-related processes: transport of citrate, phosphate, iron, and magnesium across the mitochondrial membranes; the malate-aspartate shuttle; and regulation of mitochondrial membrane permeability. There is also linkage to fatty acid response and insulin-stimulated cellular responses, all pointing to mitochondria-centered metabolite exchange and energy metabolism. This cohesive theme supports labeling the cluster as mitochondrial transport and metabolism.","confidence":"High","size":19,"edges":51,"triangles":35,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":14},{"id":"GO:0015709","count":13},{"id":"GO:0097274","count":13},{"id":"GO:0048250","count":13},{"id":"GO:0006843","count":13}]},{"hash":"2058671895956697552","title":"Temperature and sensory signaling with ion transport","description":"The top GO terms point to both stimulus sensing (temperature-related responses, pain and touch sensation, thermogenesis) and ion-handling processes (calcium and manganese transport, ion transmembrane movement, cardiac action potential repolarization). This suggests the cluster comprises proteins involved in sensing environmental stimuli and coordinating ionic fluxes that influence muscle/excitability, especially in cardiac contexts. Hence a label that captures both sensory/thermal signaling and ion transport is appropriate.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0050976","count":8},{"id":"GO:0098914","count":8}]},{"hash":"1818243841930474392","title":"Cranial bone development and osteoblast differentiation","description":"Dominant signals for cranial skeletal system development and bone development, including osteoblast fate commitment, indicate a bone formation and osteoblast differentiation theme. Additional terms on tight junctions, epithelial polarity, and membrane remodeling suggest related morphogenetic processes in craniofacial tissues. Overall, the cluster is best described as cranial bone development and osteoblast differentiation.","confidence":"High","size":19,"edges":71,"triangles":131,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043547","count":11},{"id":"GO:0051044","count":10},{"id":"GO:1904888","count":10},{"id":"GO:0070830","count":10},{"id":"GO:0036089","count":10}]},{"hash":"1887217550942553330","title":"Developmental apoptosis and cell cycle regulation","description":"These proteins show links to developmental processes across multiple tissues (neural/cerebral cortex/retina/thymus development) and apoptosis, with supporting hints of intracellular signaling and regulation of cyclin-dependent kinase activity. The combined GO terms point to a theme of developmental regulation intertwined with apoptosis and cell cycle control, rather than a single tissue- or process-specific function.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051402","count":2},{"id":"GO:0021987","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0045736","count":2},{"id":"GO:0006397","count":2}]},{"hash":"980392839322847151","title":"Nuclear Chromatin Remodeling and RNA Processing","description":"The cluster is dominated by terms tied to chromatin dynamics (chromatin remodeling, DNA topology, histone acetylation) and RNA metabolism (ncRNA-mediated silencing, splicing regulation, rRNA processing, mRNP assembly), pointing to coordinated nuclear regulation of gene expression through chromatin and RNA processing mechanisms.","confidence":"High","size":19,"edges":129,"triangles":489,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":13},{"id":"GO:0048026","count":13},{"id":"GO:0000464","count":12},{"id":"GO:0006283","count":11},{"id":"GO:2000616","count":10}]},{"hash":"1994269725143519661","title":"Mitotic Regulation and Signaling Cluster","description":"This cluster centers on regulatory signaling processes linked to cell division (G2/M transition, mitotic spindle pole separation) and various signaling pathways (insulin, PDGF receptor, autophosphorylation) alongside immune and developmental signals (innate immune response, heart development, synaptic potentiation). While some terms (like abscisic acid signaling) may be unrelated or species-specific noise, the overarching theme is regulation of signaling pathways that coordinate growth, division, and immune responses.","confidence":"Medium","size":19,"edges":165,"triangles":873,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0000086","count":3},{"id":"GO:0046626","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0060291","count":3}]},{"hash":"1485757123819133873","title":"Cell Migration and Adhesion Signaling","description":"The cluster\u2019s top GO terms consistently point to cytoskeleton-driven movement and cell\u2013environment interactions (actin filament bundle assembly, cell migration, integrin-mediated signaling, epithelial polarity). Additional terms touch on apoptotic cell engulfment and phosphatidylserine exposure, with supportive growth factor signaling (PDGF receptor) and regulation of Ras, plus some development-related terms (muscle, myelination). Taken together, the strongest shared theme is cell adhesion and migration signaling, with related processes in clearance and morphogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043652","count":2},{"id":"GO:0048008","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0051017","count":2}]},{"hash":"2149410908432509779","title":"Spliceosome-regulated mRNA processing","description":"The GO terms point to regulation of splicing via the spliceosome (positive/negative regulation, alternative splicing) plus broader mRNA processing/modification and stress-related RNA regulation, suggesting a cohesive module focused on RNA maturation and gene expression control under stress.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0048025","count":3},{"id":"GO:1901407","count":3}]},{"hash":"680499413407114934","title":"Muscle and vascular morphogenesis with axon guidance","description":"These terms indicate a focus on tissue morphogenesis across muscle and vascular systems, plus neural guidance. Negative regulation of skeletal muscle growth, smooth muscle migration, sprouting angiogenesis, and coronary artery/pericardium morphogenesis point to coordinated development and remodeling of muscle and vessels. Additional terms for axon extension and ventral spinal cord development suggest nervous system patterning, supported by cell-matrix adhesion and Hedgehog pathway signaling, with one immune-related term possibly reflecting remodeling rather than a core function. Overall, the cluster seems to reflect coordinated morphogenesis and guidance across muscle, vessels, and nerves.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0048632","count":8},{"id":"GO:0014909","count":6},{"id":"GO:0002042","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0045880","count":6}]},{"hash":"1729552689858779727","title":"Thermo- and mechanosensory calcium signaling","description":"This cluster is dominated by GO terms related to sensing environmental stimuli\u2014temperature (diet-induced thermogenesis, cellular response to temperature stimulus) and mechanical touch\u2014as well as pain perception. There are connected calcium-dependent processes (response to calcium ion, calcium-dependent cell-matrix adhesion) and tissue-relevant contexts (skin development, regulation of cardiac muscle cell action potential). The common thread appears to be sensory and signaling pathways that rely on calcium dynamics across skin and muscle contexts, with some inflammatory and ion-transport associations. Confidence: Medium","confidence":"","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0034767","count":5},{"id":"GO:0071642","count":5}]},{"hash":"2034651029211835118","title":"Developmental patterning and morphogenesis","description":"The proteins cluster around developmental patterning and morphogenesis, with GO terms for dorsal identity regulation, organ morphogenesis, and cell adhesion/cytoskeletal organization; other terms like nuclear import or membrane transport are more general, but the dominant theme appears to be regulation of development and tissue shaping.","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":11},{"id":"GO:0015991","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0048496","count":10},{"id":"GO:0045110","count":10}]},{"hash":"1877371416054168421","title":"Nucleic acid metabolism and RNA processing","description":"This cluster is enriched for DNA repair, mRNA processing (splicing, deadenylation-decapping, RNA hydrolysis), and nucleotide catabolic processes, pointing to a nuclear/nucleic-acid metabolic program. While there are some stress-related terms (apoptosis, oxidative stress) and signaling terms, the core connectivity centers on nucleic acid metabolism and RNA processing functions, justifying a label centered on nucleic acids.","confidence":"Medium","size":19,"edges":84,"triangles":142,"max_degree":14,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":3},{"id":"GO:0015967","count":3},{"id":"GO:0009154","count":2},{"id":"GO:0050850","count":2},{"id":"GO:0045292","count":2}]},{"hash":"1449621869738230011","title":"Auditory mechanosensory signaling and neural development","description":"The prominent presence of GO terms for sensory perception of sound and detection of mechanical stimulus strongly points to an auditory/mechanosensory function. Supporting terms like axonal fasciculation, locomotory behavior, and signaling pathway regulation (ERK and BMP) suggest neural development and connectivity, with cell adhesion contributing to tissue organization. Taken together, the cluster appears to center on mechanosensory (auditory) signaling coupled with neural development processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007605","count":6},{"id":"GO:0050910","count":5},{"id":"GO:0001501","count":4},{"id":"GO:0045663","count":4},{"id":"GO:0007155","count":4}]},{"hash":"632661929323775633","title":"Auditory perception and vocalization signaling","description":"The top GO terms are centered on neural signaling and behavior, including sound perception, vocalization, grooming regulation, excitatory synaptic potential, and opioid receptor pathways, indicating a coherent theme of auditory processing and vocal/social signaling. Some outlier terms exist (bile acid secretion, renal phosphate absorption), but the dominant pattern supports a neural signaling and communication focus.","confidence":"High","size":19,"edges":38,"triangles":28,"max_degree":8,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0007605","count":11},{"id":"GO:2000821","count":9},{"id":"GO:0071625","count":9},{"id":"GO:0043113","count":9},{"id":"GO:2000463","count":8}]},{"hash":"2036745541876805245","title":"Neural development and synaptic connectivity","description":"This cluster is enriched for terms tied to neural circuit formation, including positive regulation of synapse assembly, clustering of voltage-gated potassium channels, axonal fasciculation, and myelination, indicating roles in neural connectivity and maturation. Some terms like heart development and otolith morphogenesis may reflect broader developmental roles, but the predominant pattern centers on neural development.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":9},{"id":"GO:0045163","count":9},{"id":"GO:0007157","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0042552","count":8}]},{"hash":"487134883198647456","title":"Developmental Signaling Regulators","description":"The top GO terms cluster around regulation of signaling pathways (GTPase, JNK, Wnt) and developmental processes (bone and adipose tissue development) as well as apoptotic and cell polarity regulation. This pattern suggests the proteins act as regulators of signaling networks that govern development and cell fate, rather than a single, specific function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0046328","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0043525","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1208284925342722877","title":"Ribosome Biogenesis and Translation Machinery","description":"This cluster is dominated by GO terms tied to protein synthesis: translation, ribosome biogenesis, ribosomal subunit assembly, and initiation/elongation/termination of translation. The presence of both ribosome assembly and active translation regulation terms indicates these proteins function together in ribosome formation and the translation machinery, with some links to mRNA turnover during translation. ","confidence":"High","size":19,"edges":166,"triangles":888,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0042254","count":6},{"id":"GO:0006407","count":4},{"id":"GO:0000028","count":3},{"id":"GO:0042274","count":3}]},{"hash":"1763939075805164337","title":"Actin Cytoskeleton Remodeling and Vesicle Trafficking","description":"The top GO terms are dominated by actin dynamics (barbed-end capping, polymerization, bundle assembly, lamellipodium morphogenesis, nucleation) and COPII vesicle cargo loading, indicating a shared theme of actin-driven remodeling linked with vesicle trafficking; receptor signaling terms are present but secondary. This suggests a cluster centered on cytoskeletal rearrangements coordinating with membrane trafficking processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051016","count":2},{"id":"GO:0090110","count":2},{"id":"GO:0030041","count":2},{"id":"GO:0051017","count":2},{"id":"GO:2000394","count":2}]},{"hash":"1395470157034530501","title":"TGF-beta and Wnt signaling in development","description":"This cluster is enriched for GO terms related to TGF-beta signaling, Wnt pathway regulation, apoptosis, stem cell maintenance, and ureteric bud morphogenesis, with lysosome localization and inflammatory response as ancillary processes. Together, these terms point to proteins that participate in developmental signaling networks that govern cell survival, differentiation, and organ morphogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0061462","count":2},{"id":"GO:0043433","count":2},{"id":"GO:1902042","count":2}]},{"hash":"2225639336408643312","title":"Neural development and synapse formation","description":"The cluster is enriched for neural development and synaptic terms: neuroblast differentiation and retina development indicate developmental regulation, while terms related to synapse assembly and function (excitatory/inhibitory postsynaptic potentials, active zone cytoskeletal organization) point to maturation of neural circuits. APP metabolism and choline metabolism also align with neuronal biology, supporting a neural-focused theme, though a few terms like osteoblast development are present but not central.","confidence":"High","size":19,"edges":168,"triangles":920,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0002087","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0002076","count":9},{"id":"GO:2000463","count":8}]},{"hash":"2158311327817110262","title":"Zinc ion homeostasis and oxidative stress response","description":"Proteins in this cluster are enriched for zinc-related processes: intracellular zinc ion homeostasis, zinc ion import across the plasma membrane, and detoxification of zinc ion, indicating a cohesive role in zinc regulation and transport. Supporting terms include cadmium ion transport and cellular oxidant detoxification, plus responses to hydrogen peroxide and vitamin E, all consistent with a broader metal-transport and oxidative-stress management program. While some terms like limb development appear, the dominant signal centers on zinc handling and associated oxidative stress responses, suggesting the cluster reflects zinc homeostasis and related detox/transport mechanisms.","confidence":"High","size":19,"edges":23,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006882","count":4},{"id":"GO:0070574","count":4},{"id":"GO:0010312","count":4},{"id":"GO:0033197","count":3},{"id":"GO:0042542","count":3}]},{"hash":"2100329278668948147","title":"Developmental morphogenesis and neural connectivity","description":"The top GO terms point to broad developmental processes (heart development, imaginal disc polarity, salivary gland branching) and neural patterning (Roundabout signaling, paranode localization, synapse assembly). This combination suggests a cluster of proteins involved in developmental signaling that shapes tissue morphogenesis and neural connectivity.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0002175","count":2},{"id":"GO:0016336","count":2},{"id":"GO:0050929","count":2}]},{"hash":"2187660939253320382","title":"Nuclear gene expression and ribosome biogenesis","description":"GO terms in this cluster center on nuclear activities: chromatin remodeling and DNA-templated transcription, along with mitotic cell cycle and cell division, plus RNA processing and maturation of rRNA and ribosomal subunits. The combination suggests a cohesive theme of nuclear gene expression control coupled with ribosome biogenesis, consistent with growth signaling such as TORC1. Overall, the proteins likely function in nuclear regulation of transcription and ribosome assembly.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":2},{"id":"GO:1904263","count":2}]},{"hash":"501319474557329445","title":"Neural and vascular development signaling","description":"The top GO terms cluster around neural activity (regulation of synaptic vesicle endocytosis, neurotransmitter secretion, regulation of GTPase activity) and cardiovascular/vascular development (heart development, blood coagulation, VEGF receptor-2 signaling, retina layer formation, cell adhesion). While an ABA signaling term appears, the majority point to neural signaling together with vascular/heart development, suggesting a neural-vascular development theme for this cluster.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0007596","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0007155","count":2}]},{"hash":"77802810816418417","title":"Neural development and cognitive function","description":"The top GO terms cluster around brain development and function: oligodendrocyte differentiation and myelination, long-term synaptic depression, learning and memory, and sensory-related responses (mechanical and temperature/pain perception). There are also developmental terms like craniofacial suture morphogenesis and amelogenesis, which can relate to neural crest derivatives, suggesting a shared developmental context. Taken together, the group seems to center on neural development and cognitive/sensory processing, with some related craniofacial development signals. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048709","count":3},{"id":"GO:0097094","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0097186","count":2},{"id":"GO:0050965","count":2}]},{"hash":"803948025469465212","title":"Retroviral DNA Integration and Latency","description":"The top GO terms point to integration of viral DNA, proviral latency, viral entry into the host nucleus, RNA-templated DNA synthesis, and DNA replication/recombination, all characteristic of the retroviral life cycle and provirus maintenance. Additional terms on RNA silencing suppression and host apoptosis reflect typical viral strategies to manipulate host defenses and cell fate. Overall, the cluster likely represents retroviral genome integration and replication with host interactions.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":9},{"id":"GO:0075713","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0075732","count":5}]},{"hash":"1659472402935603070","title":"TLR signaling and inflammation","description":"The terms show strong enrichment for Toll-like receptor signaling pathways (TLR4, TLR7/8/10) and MyD88-dependent signaling, plus inflammatory response, pointing to a group of proteins involved in innate immune sensing and inflammation. A couple of outlier terms (cornea development, axis specification) may reflect annotation noise, but the core theme is TLR-driven immune signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002322","count":3},{"id":"GO:0002755","count":2},{"id":"GO:0034166","count":2},{"id":"GO:0034158","count":2},{"id":"GO:0051770","count":2}]},{"hash":"208182143417453955","title":"Membrane Transporters (various substrates)","description":"This cluster is dominated by GO terms for transmembrane transport of diverse substrates (vitamin, galactose, sialic acid, fucose, xenobiotics, nitrate/nitrite) and including neurotransmitter loading into vesicles, indicating a cohesive theme of membrane transport activity across substrates. The electron transport chain term is less central to the shared pattern. Confidence: High","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":3},{"id":"GO:0006924","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0015757","count":2},{"id":"GO:0015739","count":2}]},{"hash":"1248489668554652584","title":"Embryonic development and morphogenesis","description":"This cluster is dominated by GO terms related to embryonic development and tissue morphogenesis across various lineages (heart cushions, cartilage, placenta, left-right patterning, cranial skeleton, eye morphogenesis, pancreatic development, etc.), suggesting a broad developmental role rather than a single molecular function. The lack of edges does not negate a coherent theme; it simply reflects the current network structure. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003323","count":6}]},{"hash":"2230405873125163403","title":"SCF/Ubiquitin-Ligase Regulation of Mitosis","description":"The cluster is characterized by GO terms for SCF-dependent ubiquitin-proteasomal protein degradation, G2/M transition, mitotic cell cycle, chromosome segregation, and protein neddylation (and K11-linked ubiquitination), indicating a cohesive role in driving mitosis through controlled proteolysis; the presence of embryonic development and DNA repair terms may reflect broader cell-cycle and genome maintenance contexts.","confidence":"High","size":18,"edges":148,"triangles":739,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":18},{"id":"GO:0000086","count":17},{"id":"GO:0016032","count":16},{"id":"GO:0070911","count":16},{"id":"GO:0070979","count":16}]},{"hash":"1551283806039370846","title":"Metabolic Growth and Stress Response","description":"The top GO terms point to a theme of metabolic adaptation (asparagine and triglyceride catabolism, biotin biosynthesis) coupled with responses to nutrients and toxic substances, along with cell growth and maintenance of translational fidelity. This combination suggests a cluster centered on metabolic and growth regulation in the context of nutrient and stress signals, rather than a single specific pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0009636","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0016049","count":3},{"id":"GO:0006530","count":2}]},{"hash":"611885996390345172","title":"Neurodevelopment and Axon Signaling","description":"The proteins show a coherent enrichment for nervous system development, neurogenesis, transmission of nerve impulses, and localization to the paranode region of axons, along with a receptor tyrosine kinase signaling pathway, all pointing to neural development and signaling processes. Some terms like apoptosis and angiogenesis can accompany development, and one outlier (vagina development) is less consistent with neural themes, but the dominant signal is neural development and axon-associated signaling.","confidence":"Medium","size":18,"edges":146,"triangles":716,"max_degree":17,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060068","count":7},{"id":"GO:0008284","count":7},{"id":"GO:0002175","count":7},{"id":"GO:0022008","count":7},{"id":"GO:0006915","count":7}]},{"hash":"372235662190235426","title":"Endomembrane trafficking and vesicle formation","description":"Based on the top GO terms, the cluster centers on intracellular vesicle handling: protein retention in the Golgi, intralumenal vesicle formation, transport to vacuole via multivesicular body sorting, and ESCRT-related budding. These indicate a cohesive function in membrane trafficking within the endomembrane system and vesicle formation, rather than other processes. Some terms (cell division and mitotic chromosome condensation) and viral budding-related terms may be collateral, but the dominant pattern is vesicle formation and Golgi/endosome transport.","confidence":"Medium","size":18,"edges":31,"triangles":1,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045053","count":4},{"id":"GO:0070676","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0031629","count":4},{"id":"GO:0043328","count":3}]},{"hash":"138851395667952583","title":"Neurodevelopmental and Centrosome-Cilium Regulators","description":"This cluster's terms point to neural development (retina and brain) and transcriptional regulation, suggesting regulators of neurodevelopment. It also includes centrosome cycle, spindle assembly, and cilium assembly terms, indicating involvement in cell division and ciliogenesis that accompany neural differentiation. Obsolete histone modification terms appear as annotation noise rather than core functions.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0007098","count":3}]},{"hash":"1280137414945587763","title":"Skeletal muscle development and regeneration","description":"The GO terms point to muscle-related development and regenerative processes, including skeletal muscle cell differentiation regulation and satellite cell activation in muscle regeneration, along with angiogenesis and skin development that reflect broader tissue development/remodeling. These collectively suggest a cluster centered on muscle development and tissue regeneration.","confidence":"Medium","size":18,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0031954","count":2}]},{"hash":"613837340716101902","title":"Embryonic organogenesis and tissue morphogenesis","description":"This cluster\u2019s terms span multiple developmental processes across various tissues (mammary gland branching morphogenesis, parathyroid and uterus development, vasculogenesis, somite axis specification, digestive tract development) along with cellular dynamics (Rho signaling, leading-process extension) and Golgi localization. The shared theme appears to be developmental morphogenesis rather than a single pathway or tissue, justifying a label centered on organogenesis and tissue morphogenesis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060444","count":2},{"id":"GO:0060017","count":2},{"id":"GO:0001570","count":2},{"id":"GO:0032525","count":2},{"id":"GO:0003257","count":2}]},{"hash":"2150597481817051976","title":"Developmental signaling and morphogenesis","description":"Based on GO terms, these proteins are associated with brain and kidney development, myoblast fusion, Hedgehog signaling (Smoothened), and regulation of Rho-mediated signaling, as well as synaptic vesicle exocytosis and mechanosensitive responses. The recurring theme is development and tissue morphogenesis governed by signaling and cytoskeletal dynamics, across multiple tissues, rather than a single localized function.","confidence":"Medium","size":18,"edges":8,"triangles":0,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0010796","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0031384","count":5},{"id":"GO:2000300","count":5},{"id":"GO:0071260","count":4}]},{"hash":"862230870386978017","title":"Eye Development and Visual Perception","description":"This cluster is dominated by terms related to retina and camera-type eye development, visual perception, and retina-specific development, suggesting a functional grouping around eye/vision biology. Some unrelated terms appear (e.g., heart development, nitrate assimilation), but the core signal points to vision-related proteins and associated neural signaling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0018298","count":5},{"id":"GO:0007626","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0060041","count":5}]},{"hash":"522849793335761571","title":"Neuronal signaling and synaptic plasticity","description":"The cluster shows strong representation of GO terms tied to neural function and behavior: vocalization behavior, social behavior, prepulse inhibition; and synaptic organization: postsynaptic membrane assembly, regulation of neuronal synaptic plasticity. There is also involvement in Rho-mediated signal transduction and ER-Golgi vesicle transport, which relate to neurons' trafficking and cytoskeletal dynamics essential for synapse formation and plasticity. A minority of terms (e.g., complement activation) appear as outliers, but the dominant signal points to neuronal signaling and synaptic regulation. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071625","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0015031","count":3},{"id":"GO:0060134","count":3}]},{"hash":"2005562748377080857","title":"Placental and cardiac development","description":"The top GO terms cluster around placental development (trophoblast giant cell differentiation, endocrine placental formation) and heart development (endocardial cushion EMT, left-right patterning), with cartilage morphogenesis and broader developmental contexts supporting this theme. Inflammation terms are present but not central to the core signal.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2}]},{"hash":"71167263470664343","title":"Drosophila oogenesis and ectoderm patterning","description":"This cluster centers on developmental processes relevant to Drosophila oogenesis and body axis formation: oocyte localization during germarium egg chamber formation, ectoderm development, and dorsal identity determination, along with supporting roles in cell migration and cell division. Despite a single viral process term, the dominant themes point to egg chamber formation and ectoderm patterning pathways.","confidence":"High","size":18,"edges":26,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0016477","count":3},{"id":"GO:0030720","count":3},{"id":"GO:0016032","count":2},{"id":"GO:0051211","count":2}]},{"hash":"157378161102946750","title":"Chromatin remodeling and histone modification","description":"These terms cluster around chromatin biology\u2014nucleosome assembly, chromatin remodeling, and histone acetylation\u2014with concurrent regulation of transcription by RNA polymerase II, pointing to epigenetic control of gene expression. The presence of several histone modification and chromatin-related terms supports this as the core theme, with a few signaling pathway associations likely reflecting broader regulatory contexts.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":3},{"id":"GO:0070562","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1902661","count":1},{"id":"GO:0043044","count":1}]},{"hash":"1086687496685542815","title":"Spliceosome-mediated mRNA processing regulation","description":"GO terms in the cluster center on regulation of alternative and general mRNA splicing via the spliceosome, mRNA stability, polyadenylation, modification, and translation reinitiation, pointing to a cohesive post-transcriptional RNA processing/regulation module.","confidence":"High","size":18,"edges":47,"triangles":98,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":9},{"id":"GO:0010610","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0048025","count":8}]},{"hash":"2126927739333858205","title":"Innate Immune Signaling and Ubiquitination","description":"The cluster is dominated by terms related to innate immunity and ubiquitin-mediated regulation, including innate immune response, NOD1 signaling, IL-12 production regulation, macrophage inflammatory protein production, and ubiquitination/ERAD. This suggests a cohesive module where ubiquitin-dependent pathways modulate immune signaling and antiviral host defenses, with some ancillary terms (vitamin D response, SA node regulation) likely reflecting broader annotations or context.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0030433","count":3},{"id":"GO:1902187","count":3}]},{"hash":"2196108384706080652","title":"Developmental transcriptional regulation","description":"The GO terms show transcription by RNA polymerase II and its negative regulation, paired with diverse developmental processes across multiple tissues (eye, midbrain, pituitary, lung, muscle, prostate). This suggests a cohesive theme of gene-expression regulation during development across various organs.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0021983","count":7},{"id":"GO:0060441","count":7},{"id":"GO:0030901","count":7}]},{"hash":"1535753818172993620","title":"Calcium-Dependent Muscle Contraction","description":"This cluster is dominated by GO terms related to calcium signaling and muscle contraction, including positive regulation of heart contraction, regulation of calcium release for cardiac muscle function, and atrial action potential regulation, plus skeletal muscle development and calcium ion detection. While a few vision-related terms appear, the central theme is calcium-mediated contraction in cardiac and skeletal muscle, with development processes tied to muscle tissues. Overall, the proteins likely share roles in calcium-dependent muscle function and regulation.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098735","count":6},{"id":"GO:0010881","count":6},{"id":"GO:0048741","count":6},{"id":"GO:0005513","count":6},{"id":"GO:0006469","count":6}]},{"hash":"323311404780852768","title":"Neuronal signaling and behavior modulation","description":"These terms cluster around neural communication (excitatory postsynaptic potential, GABA signaling, transmission of nerve impulse) and ion transport (sodium and potassium channels), with strong ties to behavior and learning (locomotory behavior, conditioned taste aversion, REM sleep regulation). The combination points to a module of neuronal signaling that governs motor activity, learning, and sleep regulation, with a possible secondary link to amyloid-beta regulatory processes in neural contexts.","confidence":"High","size":18,"edges":13,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":13},{"id":"GO:0007626","count":12},{"id":"GO:0007214","count":12},{"id":"GO:0035725","count":12},{"id":"GO:0001661","count":12}]},{"hash":"1476356436688105230","title":"Regulated translation and mRNA decay","description":"The cluster is dominated by GO terms for all phases of translation (initiation, elongation, termination, fidelity) and for selenocysteine incorporation, plus positive regulation of cytoplasmic translation. It also includes deadenylation-dependent mRNA decay, linking translation with RNA turnover and quality control. A non-central term on glial proliferation is likely incidental.","confidence":"High","size":18,"edges":151,"triangles":785,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0046677","count":6},{"id":"GO:0006415","count":4},{"id":"GO:2000767","count":3},{"id":"GO:0045901","count":3}]},{"hash":"1187701458122807621","title":"Nucleosome assembly and chromatin organization","description":"The proteins are strongly linked to nucleosome assembly, chromatin organization, and chromatin remodeling (e.g., nucleosome assembly, chromatin localization to chromatin, heterochromatin organization, replication-dependent chromatin assembly, transcription-coupled chromatin remodeling), indicating a cohesive role in packaging and regulating chromatin structure.","confidence":"High","size":18,"edges":141,"triangles":653,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":7},{"id":"GO:0071169","count":7},{"id":"GO:0070828","count":6},{"id":"GO:0098532","count":6},{"id":"GO:0097298","count":6}]},{"hash":"715657113582763946","title":"Phospholipid biosynthesis and choline metabolism","description":"Reasoning: The top GO terms cluster around phospholipid metabolism, notably phosphatidylethanolamine biosynthesis, ethanolamine/choline metabolic processes, and the CDP-choline pathway, indicating cohesion around phospholipid synthesis. Some outliers (DNA transposition, methionine salvage) are present but less central, so the lipid biosynthesis signal is the dominant theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006646","count":3},{"id":"GO:0016310","count":3},{"id":"GO:0006580","count":3},{"id":"GO:0006657","count":3},{"id":"GO:0019695","count":3}]},{"hash":"223022294102648063","title":"Actin Cytoskeleton Remodeling and Innate Immunity","description":"The cluster is dominated by terms tied to actin dynamics\u2014polymerization, positive regulation, and ruffle assembly\u2014and an innate immune response, indicating a focus on cytoskeletal remodeling during immune signaling. While insulin signaling, ubiquitination, and other terms are present, the strongest common theme appears to be actin-driven rearrangements linked to immune functions.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0030041","count":3}]},{"hash":"1703469835486361657","title":"Membrane fusion and organelle dynamics","description":"The cluster centers on membrane-related fusion and remodeling activities, with terms such as positive regulation of myoblast fusion, conjugation with cellular fusion, mitochondrial fusion, endosome organization, and lipid tube assembly, suggesting a common theme of vesicle trafficking and organelle fusion. There are a few broader terms like cell cycle that are less directly related, but the fusion and membrane remodeling signals dominate, supporting this label.","confidence":"Medium","size":18,"edges":139,"triangles":625,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0055114","count":2},{"id":"GO:1903833","count":1},{"id":"GO:0000747","count":1}]},{"hash":"28437041791272358","title":"Unknown","description":"The top GO terms span signaling (positive regulation of kinase activity, NF-kappaB regulation), development (spermatid development), immune response (cellular response to IL-1), RNA processing (mRNA splicing via spliceosome, P-body assembly), and even DNA transposition, with no evident single biological theme or tightly connected process driving the cluster; the lack of edges further suggests a heterogeneous group. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033674","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0030307","count":2},{"id":"GO:0042989","count":2}]},{"hash":"31044844688115102","title":"Unknown","description":"The terms span immune complement activation, developmental processes (hair follicle development and maternal axis specification), metabolism (galactose pathways and poly-hydroxybutyrate biosynthesis), transcription regulation, and cell migration, with no single shared function tying the proteins together. The lack of a cohesive theme and the absence of observable interactions suggest the cluster is functionally heterogeneous, so Unknown is appropriate.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014909","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0007313","count":3}]},{"hash":"238616997229618929","title":"Nutrient and Xenobiotic Transmembrane Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of nutrients and xenobiotics (vitamin, glucose, sodium, phosphate, and other substrates), as well as related metabolic and barrier-function terms (intestinal epithelial structure maintenance). The pattern indicates a group of membrane transporter proteins with broad substrate specificity rather than a single substrate class, consistent with roles in nutrient uptake and xenobiotic efflux in epithelia.","confidence":"High","size":18,"edges":151,"triangles":784,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":18},{"id":"GO:0006855","count":18},{"id":"GO:0042891","count":18},{"id":"GO:0019852","count":16},{"id":"GO:0042908","count":16}]},{"hash":"669959344893618794","title":"Unknown","description":"The terms cover diverse areas: chloride and sialic acid transport, transepithelial transport, and visual perception, alongside cell cycle regulation and bone morphogenesis. The lack of a clear, single functional theme linking transport with sensory perception and developmental processes suggests no cohesive biological label for the cluster. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902476","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0030321","count":1},{"id":"GO:0007601","count":1},{"id":"GO:0050908","count":1}]},{"hash":"2075756406306827308","title":"Unknown","description":"The terms span immune regulation, inflammatory signaling, stress responses, plant hormone signaling, and cell cycle/development with no single cohesive theme linking them all, so there isn\u2019t a clear functional label for this cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045083","count":3},{"id":"GO:2000171","count":3},{"id":"GO:0071642","count":3},{"id":"GO:0070427","count":3},{"id":"GO:1904908","count":3}]},{"hash":"1925833841238152132","title":"Sporulation-associated cell wall remodeling","description":"The dominant GO terms center on cell wall organization and turnover (cell wall organization, cell wall macromolecule and peptidoglycan metabolism) and on sporulation (formation of a cellular spore), with additional references to chitin responses and cell shape. These together point to a cohesive role in remodeling and biosynthesis/degradation of the cell wall during sporulation, making the label representative.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":3},{"id":"GO:0030435","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0008360","count":2},{"id":"GO:1902083","count":2}]},{"hash":"52914507232954805","title":"Glycinergic Neurotransmission and Brain Development","description":"This cluster prominently features glycine-related synaptic activity (glycine secretion, transport, and regulation of glycinergic transmission), alongside other neurotransmitter processes (serotonin and dopamine pathways) and development terms such as thalamus and adenohypophysis development. The combination suggests a theme centered on glycinergic neurotransmission within a neurodevelopmental brain context. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":9},{"id":"GO:1905847","count":8},{"id":"GO:0051610","count":8},{"id":"GO:0061537","count":8},{"id":"GO:0042420","count":8}]},{"hash":"718982889272921892","title":"Innate Immune Signaling and Inflammation Regulation","description":"The top GO terms point to innate immune pathways (NOD-like receptor signaling, regulation of IL-12 production, MIP-1alpha production) and dendritic cell differentiation, which together suggest an immune signaling and inflammatory function. Ubiquitination is a common regulatory mechanism in these pathways, supporting signal transduction and control of inflammation. While there are some terms related to stress responses (heat, mechanical stimulus), the strongest connection across the cluster is immune signaling and inflammatory regulation. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":8},{"id":"GO:0071260","count":8},{"id":"GO:0007205","count":8},{"id":"GO:0045083","count":7},{"id":"GO:0070427","count":7}]},{"hash":"899346649718090365","title":"Cardiovascular development and endothelial differentiation","description":"The top GO terms point to heart and vascular formation and differentiation, including sprouting angiogenesis, venous endothelial cell differentiation, Notch signaling in heart-field regulation, and cardiac morphogenesis, suggesting a cardiovascular development theme for this cluster. Some other terms (lipoprotein transport, DNA repair, mRNA processing, etc.) appear incidental relative to the core theme. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042953","count":3},{"id":"GO:0002040","count":3},{"id":"GO:0003213","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0033280","count":2}]},{"hash":"234620769825399719","title":"Energy metabolism and signal transduction","description":"This cluster centers on both energy production processes (electron transport chain, diet-induced thermogenesis) and key signaling pathways (Rho signaling, GPCR signaling) that regulate physiological functions such as blood pressure. The presence of nervous-system\u2013related terms (sensory perception, visual learning) suggests a broad organismal context where metabolism and signaling coordinate responses. Therefore, a concise label capturing both metabolism and signaling is most representative: Energy metabolism and signal transduction.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":14},{"id":"GO:0008542","count":14},{"id":"GO:0035025","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0010579","count":14}]},{"hash":"860435635764146473","title":"Unknown","description":"The top GO terms span immune response, various developmental processes (placental, vaginal, cartilage, fat cell), signaling (p38 MAPK), neuron axonogenesis, and transcription factor activity, with no single unifying function. The cluster also shows minimal connectivity (one edge, no triangles), suggesting it does not represent a cohesive functional module but rather a heterogeneous collection of proteins with diverse roles. ","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":13},{"id":"GO:0001893","count":12},{"id":"GO:0038066","count":12},{"id":"GO:0021952","count":12},{"id":"GO:0043433","count":12}]},{"hash":"2209989941975334856","title":"Developmental signaling and neurogenesis","description":"This cluster centers on signaling pathways involved in development (Smoothened/Hedgehog, Roundabout/ROBO, Rho signaling) and includes broad organogenesis topics (kidney, heart, nervous system, brain) along with neurogenesis and myoblast fusion, suggesting a cohesive theme of coordinated developmental signaling with neural development.","confidence":"Medium","size":17,"edges":54,"triangles":15,"max_degree":10,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0001822","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007399","count":6}]},{"hash":"171791592060943864","title":"Neural development and axon guidance signaling","description":"The cluster is dominated by GO terms related to nervous system development, axon guidance, synapse assembly, and signaling pathways (Slit/Robo, Rho, Hedgehog), including neuronal migration and myelination. While there is a broad morphogenesis term like kidney development, the overwhelming themes center on neural development and guidance cues.","confidence":"High","size":17,"edges":57,"triangles":98,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035385","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0007224","count":6},{"id":"GO:0042552","count":6},{"id":"GO:0001822","count":6}]},{"hash":"694829212147139872","title":"Neural development and synaptic signaling","description":"The cluster centers on nervous system and brain development, axon guidance, and regulation of synaptic vesicle exocytosis (ROBO signaling and Rho pathways), which together point to neuronal development and synaptic function. Some outliers (mating projection growth, immune signaling, ossification) appear in GO annotations but do not outweigh the neuronal theme.","confidence":"High","size":17,"edges":68,"triangles":71,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010796","count":7},{"id":"GO:0031384","count":7},{"id":"GO:2000300","count":7},{"id":"GO:0035385","count":7},{"id":"GO:0050852","count":7}]},{"hash":"32893121875459128","title":"Steroid and lipid metabolism","description":"The set shows strong representation of hormone biosynthesis (estrogen biosynthetic process) and hormone catabolism (androgen catabolic process), combined with multiple lipid-related processes (fatty acid elongation, 3-keto-sphinganine metabolic process, retinal metabolic process, and sphingolipid-related pathways like acetoin/poly-hydroxybutyrate biosynthesis). Although one term is obsolete and another relates to development (lung development), the majority points to a cohesive lipid and steroid metabolic theme, justifying this label as a concise summary of the cluster\u2019s function.","confidence":"Medium","size":17,"edges":130,"triangles":596,"max_degree":16,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":17},{"id":"GO:0030324","count":15},{"id":"GO:0045150","count":15},{"id":"GO:0042619","count":15},{"id":"GO:0006729","count":15}]},{"hash":"2279433358329427410","title":"Embryonic organ morphogenesis","description":"The top GO terms show development and morphogenesis across multiple vertebrate organs (eye, lung, thymus, neural tube regions like floor plate, somites), plus general transcription-related activity. This points to a broad embryonic organogenesis program rather than a single tissue-specific function, so a concise label like embryonic organ morphogenesis is appropriate and representative.","confidence":"Medium","size":17,"edges":116,"triangles":431,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0060441","count":7},{"id":"GO:0043010","count":7},{"id":"GO:0048048","count":7},{"id":"GO:0071455","count":6}]},{"hash":"1266396262247170791","title":"Glycolysis, TCA, and amino acid catabolism","description":"Reasoning: the dominant terms point to central carbon metabolism and energy production, including glycolytic process, the TCA cycle, glucose metabolism, and branched-chain amino acid catabolic process. Some non-metabolic terms are present but less represented, suggesting annotation noise. Overall, the cluster centers on energy metabolism pathways.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006099","count":3},{"id":"GO:0006470","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0006006","count":2}]},{"hash":"970995043792285037","title":"Embryonic organ morphogenesis","description":"This cluster is dominated by embryonic morphogenesis terms across multiple tissues (pituitary, hindlimb, heart, eye, habenula, male gonad, prostate), plus transcription by RNA Pol II regulation, indicating a broad role in embryonic organ development and morphogenesis.","confidence":"High","size":17,"edges":35,"triangles":10,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":12},{"id":"GO:0060527","count":11},{"id":"GO:2000288","count":11},{"id":"GO:0035116","count":11},{"id":"GO:0021986","count":11}]},{"hash":"422791387884620331","title":"Plant cell wall biosynthesis and related metabolism","description":"The top GO terms point to plant-specific processes: building and organizing the cell wall (cell wall polysaccharide biosynthetic process, cell wall organization) alongside various metabolic pathways common in plants (alkaloid metabolism, cytokinin catabolic process, L-ascorbic acid biosynthesis, methanol metabolism). This suggests a cohesive theme around cell wall biosynthesis coupled with broader plant metabolism and hormone turnover. The mix of terms, including some obsolete annotations, still centers on plant structural biosynthesis and associated metabolic activities, supporting this label, even if not all proteins are tightly connected in a single pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009820","count":3},{"id":"GO:0009086","count":2},{"id":"GO:0070592","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0019853","count":2}]},{"hash":"1558734972136686546","title":"Neurovascular signaling and guidance","description":"The dominant GO terms point to neural signaling and guidance (transmission of nerve impulse; sympathetic neuron projection guidance) and vascular chemotaxis (VEGF-driven endothelial cell migration), with supporting roles for Rho-mediated cytoskeletal signaling and cell adhesion (melanocyte adhesion). These together suggest a cluster centered on neurovascular development and signaling, with ancillary terms like nodulation and cholesterol homeostasis as possible noise.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0009877","count":2},{"id":"GO:0015734","count":2},{"id":"GO:0033344","count":2},{"id":"GO:0042632","count":2}]},{"hash":"403059323176557643","title":"Nematode molting, cuticle, and sensory biology","description":"Top GO terms cluster around nematode-specific development (molting cycle with cuticle, pharyngeal pumping) and sensory functions (sense/memory-related terms), with a few broad metabolism terms that may be incidental. This suggests a cohesive theme of nematode developmental and sensory biology, hence the label.","confidence":"Medium","size":17,"edges":21,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046306","count":1},{"id":"GO:0046196","count":1},{"id":"GO:0009970","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0043050","count":1}]},{"hash":"1135658132714718463","title":"Spliceosome-mediated mRNA processing","description":"Based on the top GO terms, the proteins cluster around mRNA splicing and processing: several terms explicitly reference spliceosome-mediated splicing (GO:0045292, GO:0048026, GO:0048025), alternative splicing (GO:0000380), and mRNA modification (GO:0016556). There are also regulatory links to mRNA stability in stress (GO:0010610) and translation reinitiation (GO:0002188). Altogether, this pattern suggests a group of RNA processing factors that regulate splicing and mRNA fate, possibly coordinating splicing decisions with translation, especially under stress. ","confidence":"Medium","size":17,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0045292","count":8},{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8}]},{"hash":"2255273948779574315","title":"Epithelial Polarity and Tight Junction Assembly","description":"The top terms are dominated by establishment of epithelial cell polarity and tight junction assembly, with calcium ion transport supporting membrane processes, suggesting a core theme of epithelial polarity and junction formation. Immune-related terms and others appear at low frequency, indicating they are less central to this cluster. Overall, the cluster most plausibly reflects proteins involved in epithelial polarity and junction assembly.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":2},{"id":"GO:0070588","count":2},{"id":"GO:0070830","count":2},{"id":"GO:2001199","count":1},{"id":"GO:0038095","count":1}]},{"hash":"1591788362763291994","title":"B cell receptor signaling and adaptive immunity","description":"Based on the top GO terms, the cluster is enriched for B cell\u2013specific signaling and functions, including B cell receptor signaling, B cell affinity maturation, and the broader adaptive immune response. Additional terms like IL-2 production and cell adhesion/migration support a role in immune activation and trafficking; a few terms (heart development, insulin signaling) may reflect pleiotropy, but the dominant theme is B cell\u2013mediated adaptive immunity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016477","count":5},{"id":"GO:0007155","count":5},{"id":"GO:0008286","count":5},{"id":"GO:0010863","count":5},{"id":"GO:1900042","count":5}]},{"hash":"858576622052728649","title":"Embryonic Development and Morphogenesis","description":"These proteins show a strong tilt toward developmental processes, including cartilage morphogenesis, placental and endocrine system development, left-right patterning, and EMT events in heart cushion formation. The shared emphasis on tissue differentiation and organ formation suggests a role in embryogenesis and organogenesis rather than a single metabolic pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":14},{"id":"GO:0060707","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0003323","count":14},{"id":"GO:0060806","count":14}]},{"hash":"2147570918626922695","title":"Developmental Regulation and Transcription","description":"This cluster is enriched for organismal development terms (multicellular development, mesoderm formation) and gene expression control (DNA-templated transcription, regulation of protein export from the nucleus), with additional signals related to hormonal and metabolic responses (peptide hormone signaling, glucose response) and dsRNA response. Collectively, these terms point to proteins that regulate development through transcriptional control and signaling pathways rather than a single biochemical function.","confidence":"Medium","size":17,"edges":61,"triangles":89,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046827","count":15},{"id":"GO:0007275","count":15},{"id":"GO:0071333","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0043330","count":15}]},{"hash":"1695277137949805265","title":"Epithelial Polarity and Cytoskeletal Remodeling","description":"The cluster is dominated by GO terms for establishing epithelial cell polarity, actin filament bundle assembly, and cell migration, which collectively point to proteins coordinating cell polarity with cytoskeletal remodeling to drive movement. Additional terms around positive regulation of GTPase activity fit with Rho-family signaling that governs actin dynamics, while immune-related terms appear as secondary regulatory connections. Overall, the shared theme is polarization-linked cytoskeletal remodeling in epithelial contexts.","confidence":"High","size":17,"edges":26,"triangles":13,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0045083","count":2}]},{"hash":"1003114659734153958","title":"Lymphocyte development and cytokine signaling","description":"The top GO terms cluster around immune system processes, including interleukin-4 production, B cell maturation, hemopoiesis, NK T cell differentiation, and responses to interleukin-7, along with signaling pathways (PI3K-AKT, Ras) and cytoskeletal dynamics (filopodium assembly, microtubule depolymerization) that support immune cell development, activation, and movement. This cohesive pattern suggests a group of proteins involved in lymphocyte development and cytokine-mediated signaling rather than unrelated functions.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032633","count":2},{"id":"GO:0002344","count":2},{"id":"GO:0030097","count":2},{"id":"GO:0001865","count":2},{"id":"GO:0098761","count":2}]},{"hash":"24729981993954112","title":"GABAergic Signaling and Circadian Regulation","description":"This cluster shows a strong enrichment for neural functions: gamma-aminobutyric acid signaling, regulation of nerve impulse transmission, innervation, and locomotory behavior, plus regulation of sleep/wake circadian cycles. The presence of sodium ion transport and drug-response terms (e.g., response to cocaine) aligns with neuronal excitability and behavioral modulation, supporting a cohesive neural signaling and circadian theme. Some terms like amyloid-beta formation and acrosome-related regulation may reflect broader cellular processes but do not override the neural-centric pattern.","confidence":"High","size":17,"edges":18,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":6},{"id":"GO:2001023","count":6},{"id":"GO:0042320","count":6},{"id":"GO:1902004","count":6},{"id":"GO:0051971","count":6}]},{"hash":"370790008307364537","title":"Embryonic Development and Morphogenesis","description":"The dominant GO terms cluster around embryo formation, placental/trophoblast differentiation, heart development (EMT in endocardial cushions), left-right axis patterning, and organ development (endocrine/pancreatic and cartilage morphogenesis), all pointing to broad developmental and morphogenetic processes with cytoskeletal remodeling involved.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003323","count":3}]},{"hash":"1577931554792924902","title":"Neuro-immune development and signaling","description":"The cluster shows a mix of neural development terms (neuron projection development, transmission of nerve impulse, sympathetic neuron projection guidance, myelination) and immune signaling terms (innate immune response, regulation of interferon-alpha and IL-10, CD40 signaling). This suggests a theme of neural development influenced by immune signaling, or vice versa, i.e., neuro-immune interactions during development. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035855","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0072102","count":3},{"id":"GO:0031643","count":3}]},{"hash":"164052187603608406","title":"Xenobiotic and Alkaloid Detoxification","description":"This cluster shows enrichment for catabolic and metabolic processes of xenobiotics and alkaloids (carbazole, isoquinoline alkaloids, dibenzo-p-dioxin, insecticides) and related lipid metabolism (cholesterol) plus responses to food and ions, suggesting a cohesive function in detoxification and degradation of aromatic/exogenous compounds.","confidence":"Medium","size":17,"edges":10,"triangles":0,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0046232","count":8},{"id":"GO:0032094","count":7},{"id":"GO:0060736","count":6},{"id":"GO:0017143","count":6},{"id":"GO:0033076","count":6}]},{"hash":"669602188541173270","title":"Broad Metabolic and Translational Functions","description":"The top GO terms span both biosynthetic (antibiotic and clavulanic acid biosynthesis) and diverse catabolic processes (carnitine, oxalate, xanthine, PC compound degradation, and plant hormone- or xenobiotic-related catabolism), plus translation and mitochondrial translational initiation. This suggests a cluster of proteins involved in various metabolic pathways with an accompanying role in protein synthesis machinery, rather than a single cohesive pathway. ","confidence":"Medium","size":17,"edges":37,"triangles":20,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0043427","count":1},{"id":"GO:0042413","count":1},{"id":"GO:0033611","count":1}]},{"hash":"1939563070945761187","title":"tRNA Aminoacylation and Translation Regulation","description":"The top GO terms are dominated by tRNA aminoacylation (phenylalanyl-, methionyl-, lysyl-tRNA synthetases), tRNA processing, and translation, with a few development-related terms appearing at lower counts. This points to a cohesive cluster centered on the translation machinery, with some incidental developmental annotations.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001541","count":2},{"id":"GO:0043583","count":2},{"id":"GO:0048514","count":1},{"id":"GO:0006432","count":1},{"id":"GO:0006412","count":1}]},{"hash":"543140119482995563","title":"Mitochondrial energy regulation and apoptosis signaling","description":"This cluster centers on mitochondrial processes: regulation of ATP metabolism and ATP-dependent activity, mitochondrial depolarization, and activation of apoptotic pathways via outer membrane permeabilization. Heme biosynthesis and protein targeting to mitochondrion are mitochondria-associated, aligning with erythrocyte differentiation and mitochondrial function in erythropoiesis. While a few terms are broader (translation, endothelial regulation), the core signals converge on mitochondrial energy status and programmed cell death, justifying a mitochondria-focused label.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006783","count":3},{"id":"GO:0032780","count":3},{"id":"GO:1903578","count":3},{"id":"GO:0051882","count":3},{"id":"GO:1904925","count":3}]},{"hash":"1751323572446070542","title":"Unknown","description":"The GO terms span transcription, DNA repair, heart and CNS development, angiogenesis, and germline stem cell processes, a highly diverse set with little overlap. This makes it hard to define a cohesive biological theme for the cluster, so a concise, representative label is not supported.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070816","count":1},{"id":"GO:0006289","count":1},{"id":"GO:0006360","count":1},{"id":"GO:0060250","count":1},{"id":"GO:0060914","count":1}]},{"hash":"1959899692718307584","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0006396","count":1},{"id":"GO:0002188","count":1},{"id":"GO:0010610","count":1}]},{"hash":"400938645780933701","title":"T cell activation and cytoskeletal dynamics","description":"Based on the GO terms, the cluster is dominated by immune signaling relevant to T cell activation (T cell receptor\u2013MHC interactions and activation) and by cytoskeletal processes (microtubule-based movement and protein homooligomerization), with additional hints of adhesion regulation (integrin activation) and interferon response. Some terms (spinal cord development, hyaluronan metabolism, platelet activation) are more peripheral, but the core theme centers on T cell\u2013mediated immune activation and the cytoskeletal machinery that supports cell movement and adhesion.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0006924","count":3},{"id":"GO:0002291","count":3},{"id":"GO:0035455","count":3},{"id":"GO:0030212","count":3},{"id":"GO:0033623","count":3}]},{"hash":"1929597846955767556","title":"Cardiac and vascular morphogenesis","description":"The cluster's top terms include ventricular cardiac muscle tissue morphogenesis, regulation of atrial cardiac muscle cell action potential, and branching involved in blood vessel morphogenesis, pointing to a cardiovascular/muscle development theme. We also see terms on muscle differentiation and organal response to stress; a few outliers like short-term memory appear less central. Overall, the dominant signal is heart and vessel morphogenesis and muscle signaling, so Cardiac and vascular morphogenesis fits best.","confidence":"Medium","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055010","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0097274","count":4},{"id":"GO:0007614","count":4},{"id":"GO:2001015","count":4}]},{"hash":"1537267195343800490","title":"Metabolic redox and translation cluster","description":"This cluster shows enrichment in redox-related processes (cell redox homeostasis, oxidation-reduction), alongside metabolic activities (pyridoxine biosynthesis, zinc ion homeostasis) and translation, suggesting a grouping around core metabolism and cellular redox balance with some ancillary signaling terms. The mix is coherent enough to label as metabolic-redox/translation\u2013oriented, though some signaling/wound-healing annotations add noise.","confidence":"Medium","size":17,"edges":73,"triangles":94,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0008615","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0006882","count":1}]},{"hash":"822576860840265108","title":"TGF-\u03b2 signaling and developmental morphogenesis","description":"This cluster is enriched for GO terms related to cellular response to TGF-\u03b2 stimulus and regulation of TGF-\u03b2 receptor signaling, plus terms on fibroblast migration and branching morphogenesis (lung) and uterus development. PI3K-Akt signaling terms suggest cross-talk with TGF-\u03b2\u2013driven pathways influencing cell migration and development. The overarching theme is TGF-\u03b2\u2013mediated development and morphogenesis with associated cell movement.","confidence":"High","size":17,"edges":28,"triangles":17,"max_degree":15,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071560","count":8},{"id":"GO:0030512","count":8},{"id":"GO:0010763","count":6},{"id":"GO:0060449","count":6},{"id":"GO:0035307","count":6}]},{"hash":"344635426171928325","title":"Secretory trafficking and axon guidance signaling","description":"Based on the top GO terms, the cluster is enriched for vesicle transport between the ER and Golgi, vacuolar targeting, and retrograde trafficking, illustrating a core secretory pathway role. It also shows axon guidance-related signaling (Roundabout/Robo, Smoothened) and ERK cascade modulation, indicating involvement in signaling processes that guide development and cellular navigation. While some terms refer to broader developmental contexts (kidney development, ossification), the common theme ties trafficking with developmental signaling. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006623","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0007411","count":3},{"id":"GO:0007224","count":3}]},{"hash":"1860301203887538251","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019695","count":2},{"id":"GO:0040038","count":1},{"id":"GO:0007292","count":1},{"id":"GO:0061164","count":1},{"id":"GO:0051758","count":1}]},{"hash":"442136745168332430","title":"Plant AGP glycosylation and mucilage development","description":"The top GO terms point to arabinogalactan protein metabolic processes and related O-linked glycosylation (hydroxyproline-type), plus biosynthesis of AGP-associated glycans and plant developmental processes like root hair and seed coat mucilage formation. This suggests a cohesive theme around plant cell-surface glycoproteins (AGPs) and their glycosylation driving development and extracellular matrix biosynthesis. Some terms (e.g., insect or egg chamber-related processes) appear as outliers, but the dominant signal aligns with AGP glycosylation and mucilage/epithelial development in plants.","confidence":"Medium","size":17,"edges":21,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010405","count":2},{"id":"GO:0001744","count":2},{"id":"GO:0018258","count":2},{"id":"GO:0010493","count":2},{"id":"GO:0030311","count":2}]},{"hash":"308496103412921257","title":"Neuronal synaptic signaling and cytoskeleton dynamics","description":"The cluster is enriched for GO terms related to Rho signaling regulation, actin cytoskeleton organization, and synaptic plasticity (long-term depression; excitatory postsynaptic potential), along with nervous-system\u2013associated behaviors (grooming, vocalization) and ECM-cell signaling that can influence synapse structure and signaling. This pattern supports a cohesive theme of neuronal signaling together with cytoskeletal remodeling at synapses.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0035426","count":3},{"id":"GO:2000463","count":2},{"id":"GO:0035234","count":2},{"id":"GO:2000821","count":2}]},{"hash":"275481965229195582","title":"Epidermal Development and Wound Healing","description":"The terms center on skin development, epidermal cell spreading during wound healing, and ERK signaling, alongside transcriptional regulation and cell-substrate junctions. This combination points to an epidermal differentiation/repair program involving signaling, adhesion, and migration in skin tissue, with some ancillary terms (lipid transport regulation and complement signaling) contributing less to the core theme. Overall, the cluster appears cohesive around epidermal development and repair processes.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0070371","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0007044","count":1}]},{"hash":"1007436319915850770","title":"Fish embryogenesis and larval development","description":"The top GO terms center on early developmental events and larval behaviors in fish, including anterior lateral line development, zygotic anterior/posterior axis determination, embryonic digestive tract development, hatching behavior, and phototaxis. These frequently co-occur in zebrafish-like contexts, suggesting a cohesive theme of embryogenesis and early larval function. A few outlier terms related to fertilization or mating behavior appear but do not outweigh the dominant developmental pattern. Confidence: High","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048899","count":2},{"id":"GO:0007339","count":2},{"id":"GO:0071555","count":2},{"id":"GO:0042331","count":2},{"id":"GO:0010923","count":1}]},{"hash":"1754682251039807539","title":"Viral defense and innate immune signaling cluster","description":"This cluster centers on antiviral defense and innate immunity, with terms for defense response to virus and innate immune response, plus regulation of RIG-I signaling, viral RNA replication, miRNA-mediated gene silencing, and ubiquitination as regulatory layers.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007098","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0045869","count":2}]},{"hash":"1215482643635954130","title":"Axon Guidance and Neural Development","description":"The top GO terms point to neuronal pathfinding and development, including sympathetic neuron projection guidance, axon guidance via semaphorin-plexin signaling, axonal fasciculation, branchiomotor neuron guidance, trigeminal nerve organization, and neural crest migration. While a single immune-related term appears, the dominant pattern is neural wiring and axon pathfinding, suggesting this cluster centers on neuronal development processes.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":2},{"id":"GO:0048803","count":2},{"id":"GO:0097491","count":2},{"id":"GO:1902287","count":2},{"id":"GO:0097490","count":2}]},{"hash":"2102944108849969036","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033344","count":2},{"id":"GO:0010742","count":2},{"id":"GO:0030299","count":2},{"id":"GO:0010899","count":2},{"id":"GO:0035426","count":2}]},{"hash":"2120459372519926317","title":"Neural development and myelination regulation","description":"This cluster is best described by neural development and myelination regulation, as the top GO terms emphasize positive regulation of synapse assembly and myelination. The presence of terms related to VEGF/angiogenesis and bone mineralization suggests additional, less central roles in vascular and skeletal remodeling, but the strongest signal centers on CNS maturation and myelin-associated processes, including calcium-activated lipid scrambling linked to membrane dynamics in myelin. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:1900747","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0045794","count":2}]},{"hash":"2053747164467386705","title":"snoRNP Assembly and Nucleotide Salvage","description":"This cluster is strongly linked to box C/D snoRNP assembly and various nucleotide metabolism processes (AMP salvage, adenosine salvage, dATP biosynthesis), with protein heterooligomerization supporting ribonucleoprotein complex formation. While there are additional metabolic terms, the prominent signals point to RNA-processing complex assembly and nucleotide salvage/biosynthesis as the core theme.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":4},{"id":"GO:0000492","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0061615","count":2},{"id":"GO:0044209","count":2}]},{"hash":"1177946440289210165","title":"Viral life cycle and host interaction","description":"The cluster centers on virus-encoded assembly, entry into the host, uncoating, genome replication and integration/latency, and eventual release, consistent with the viral life cycle. The terms emphasize viral processes rather than cellular pathways, supporting this concise label.","confidence":"High","size":16,"edges":23,"triangles":18,"max_degree":7,"top_function":"protein folding","top_go_terms":[{"id":"GO:0019068","count":8},{"id":"GO:0000413","count":8},{"id":"GO:0030260","count":8},{"id":"GO:2000276","count":8},{"id":"GO:0006278","count":8}]},{"hash":"1582277949143907979","title":"Oxidative Stress and Inflammation","description":"The top GO terms cluster around oxidative stress and inflammatory processes (oxidation-reduction, oxidant detoxification, inflammatory response, hypoxia response) suggesting a module focused on stress adaptation and immune-like responses. Corticosterone response reinforces the stress-related theme, while other terms (dopamine catabolic process, lamellocyte differentiation, neural plasticity regulation, glial apoptosis) may reflect broader neuroimmune or stress-related cross-talk. Overall, this set points to a stress-response/inflammation cluster rather than a single, tightly defined pathway.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0098869","count":4},{"id":"GO:0051412","count":4},{"id":"GO:0042420","count":3},{"id":"GO:0035171","count":3}]},{"hash":"2288395308290282704","title":"Musculoskeletal and cardiac development","description":"The cluster\u2019s top GO terms center on bone remodeling (osteoblast/osteoclast differentiation), muscle differentiation and regeneration, and cardiac development (right ventricle formation, outflow tract morphogenesis), suggesting a shared theme of developmental regulation across musculoskeletal and cardiovascular lineages, despite some neural and fibroblast-related terms present.","confidence":"Medium","size":16,"edges":116,"triangles":508,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":9},{"id":"GO:0060766","count":9},{"id":"GO:0014737","count":8},{"id":"GO:0003219","count":8},{"id":"GO:0021858","count":8}]},{"hash":"297976562139564010","title":"DNA maintenance and purine nucleotide metabolism","description":"The cluster is enriched for DNA repair, recombination, and replication terms, together with AMP salvage, purine interconversion, and ADP biosynthesis, indicating a common theme of genome maintenance and nucleotide supply for DNA synthesis and repair. Some annotations like liver and brain development and xenobiotic response are less central and may reflect broader expression or annotation noise; overall the dominant signal supports a DNA/nucleotide metabolism role.","confidence":"Medium","size":16,"edges":108,"triangles":419,"max_degree":15,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006281","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0044209","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0042493","count":3}]},{"hash":"1362107409558496564","title":"Embryonic morphogenesis and organ development","description":"The proteins are enriched for development- and morphogenesis-related GO terms across multiple organs (heart, eye, limb, placenta, gonads, habenula, prostate), suggesting a cohesive theme of embryonic organogenesis rather than a single tissue, hence this label.","confidence":"High","size":16,"edges":25,"triangles":5,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0060527","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0035116","count":7}]},{"hash":"534813853536610513","title":"Nematode morphogenesis and molting","description":"The cluster is anchored by nematode-specific developmental processes such as face morphogenesis and the molting cycle with cuticle formation, plus nematode pharyngeal pumping, suggesting a theme of developmental remodeling. Signaling terms like ERK cascade and glutamatergic synaptic regulation could accompany maturation, supporting a developmental context. Some terms (angiogenesis, vasoconstriction, antibiotic response) are broader or less nematode-specific, so the cohesion is partial but centers on nematode development and cuticle remodeling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0060325","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0043050","count":3},{"id":"GO:0018996","count":3}]},{"hash":"1079294405157515224","title":"Choline metabolism and phospholipid biosynthesis","description":"Most frequent GO terms map to lipid metabolism: CDP-choline pathway, phosphatidylethanolamine biosynthesis, choline and ethanolamine metabolic processes. This suggests enzymes involved in membrane phospholipid production and related choline/ethanolamine pathways, with a few peripheral terms (e.g., threonine biosynthesis) not altering the main theme.","confidence":"High","size":16,"edges":49,"triangles":76,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0009088","count":5},{"id":"GO:0019284","count":4},{"id":"GO:0006646","count":4},{"id":"GO:0016310","count":4},{"id":"GO:0006580","count":4}]},{"hash":"436292895657613675","title":"Mitochondrial and chloroplast protein import","description":"This cluster is characterized by GO terms for importing proteins into organelles, notably mitochondrial matrix import (GO:0030150), mitochondrial inner membrane insertion (GO:0045039), and chloroplast stroma import (GO:0045037). These terms together point to a shared function in targeting and inserting proteins into organelles, despite some unrelated terms present. The strongest signal is organelle protein import across membranes, primarily for mitochondria and chloroplasts.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":3},{"id":"GO:0032094","count":3},{"id":"GO:0030150","count":3},{"id":"GO:0045037","count":3},{"id":"GO:0045039","count":3}]},{"hash":"935036733319853155","title":"Neuronal development and vesicle transport","description":"This cluster centers on GO terms for nervous system development and neuron projection morphogenesis, complemented by several vesicle trafficking processes (ER to Golgi transport, endosome transport, vacuole targeting). The combination suggests proteins involved in neuronal differentiation and intracellular transport, with some broader developmental roles indicated by spermatid development and lifespan terms.","confidence":"Medium","size":16,"edges":17,"triangles":0,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0006888","count":3},{"id":"GO:0006623","count":3}]},{"hash":"1540353549304064934","title":"Ion and Metabolite Transmembrane Transporters","description":"The top GO terms are all transmembrane transport functions across membranes, covering ions (sodium, nitrate, nitrite, phosphate), nutrients (galactose, vitamins), metabolites (4-hydroxyphenylacetate), xenobiotics, and even neurotransmitter loading into synaptic vesicles. This points to a cluster of diverse membrane transporter proteins whose shared function is moving ions and small molecules rather than catalysis or signaling.","confidence":"High","size":16,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":4},{"id":"GO:0035461","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0035435","count":3},{"id":"GO:1900754","count":3}]},{"hash":"1859491572195947753","title":"Cytosolic Translation Initiation and Ribosome Assembly","description":"Based on the dominant GO terms, the proteins in this cluster are linked to cytosolic ribosome assembly and the initiation of translation (cytoplasmic ribosome assembly; formation of cytoplasmic translation initiation complex; translational initiation; cytoplasmic translational initiation). A couple of terms related to development and synapse regulation appear but are likely incidental noise relative to the strong translation-initiation signal. Thus the core theme is translation initiation machinery in the cytosol.","confidence":"Medium","size":16,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042256","count":1},{"id":"GO:0001732","count":1},{"id":"GO:1905696","count":1},{"id":"GO:1905606","count":1},{"id":"GO:0006413","count":1}]},{"hash":"1192899995733930717","title":"Ubiquitin-Dependent Regulation of Apoptosis and NF-\u03baB","description":"The top GO terms point to ubiquitin-mediated protein degradation and modification (ubiquitin-dependent proteolysis, autoubiquitination, histone ubiquitination) alongside TNF signaling and I-kappaB phosphorylation, which together indicate a coherent theme of ubiquitin-driven regulation of apoptosis and NF-\u03baB\u2013mediated transcription. Some terms are obsolete or peripheral, but the core pattern supports this labeling.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0070535","count":6},{"id":"GO:0033209","count":6},{"id":"GO:0090073","count":6},{"id":"GO:0042981","count":6}]},{"hash":"1936420647530288065","title":"Unknown","description":"The top GO terms are highly diverse (sound perception, protein catabolic process, DNA repair, adhesion, signaling) with no evident common function or pathway connecting the proteins, and several terms are obsolete, so a coherent theme cannot be established.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0030163","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0000012","count":1},{"id":"GO:0010835","count":1}]},{"hash":"426044504198448515","title":"Lipid metabolism and membrane trafficking","description":"The cluster is driven by lipid-related processes: positive regulation of fatty acid biosynthesis, phosphatidylethanolamine biosynthesis, and phosphatidylinositol metabolism, alongside regulation of receptor-mediated endocytosis. These point to lipid biogenesis and membrane trafficking as a unifying theme. Some other terms (spermatogenesis, glutamatergic synaptic transmission) may reflect broader cellular roles or annotations, reducing cohesion. Overall, the label captures the strongest recurring theme, albeit with some noise.","confidence":"Low","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045723","count":2},{"id":"GO:0006646","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0048260","count":1},{"id":"GO:0046580","count":1}]},{"hash":"773306594917144735","title":"Nucleic acid repair and antiviral defense","description":"This cluster shows several GO terms centered on genome maintenance and defense against foreign DNA, notably double-strand break repair via homologous recombination, clearance of foreign intracellular DNA, and defense response to virus. While other terms touch on various metabolic pathways (NAD/NADP biosynthesis, porphyrin, cobalt/vitamin biosynthesis), the strongest coherent signal ties to nucleic acid repair and antiviral defense. Confidence: Medium.","confidence":"","size":16,"edges":96,"triangles":293,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0000724","count":1},{"id":"GO:0000738","count":1},{"id":"GO:0044355","count":1},{"id":"GO:0051607","count":1},{"id":"GO:0032508","count":1}]},{"hash":"634289464786100392","title":"ECM remodeling and morphogenesis","description":"The top GO terms cluster around extracellular matrix remodeling (collagen catabolic process, basement membrane disassembly) and developmental morphogenesis (lung branching, intramembranous ossification, bone resorption, neural precursor proliferation, decidualization). This points to proteins involved in remodeling the ECM during tissue development and organ formation, rather than a single highly specific function. A secondary, less central signal is immune-related in the context of remodeling environments.","confidence":"Medium","size":16,"edges":73,"triangles":207,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:2000179","count":12},{"id":"GO:0060441","count":12},{"id":"GO:0030574","count":12},{"id":"GO:0034769","count":12},{"id":"GO:0050790","count":12}]},{"hash":"692629113628056280","title":"Ubiquitin-Dependent Protein Turnover","description":"The most represented function is ubiquitin-dependent protein catabolic process, with additional terms about regulation of ubiquitination and protein turnover. This suggests the cluster centers on ubiquitin-mediated protein regulation, even though other GO terms (circadian rhythm, phototropism, muscle development, immune signaling) reflect broader regulatory roles where ubiquitination modulates diverse processes. The lack of interaction edges indicates this may be a collection of proteins linked by a common regulatory theme rather than a tightly connected module.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:1900477","count":7},{"id":"GO:0042748","count":7},{"id":"GO:0009638","count":7},{"id":"GO:0036268","count":7}]},{"hash":"735374175544151763","title":"Mitochondrial membrane transport and regulation","description":"The dominant GO terms describe transport activities across mitochondrial membranes (thiosulfate, phosphate, citrate, thiamine pyrophosphate, magnesium) and regulatory processes affecting mitochondrial membrane properties (permeability, membrane potential, and fission). This pattern points to a cluster of mitochondrial transporters and regulators rather than non-mitochondrial functions. Note that a couple of terms are obsolete, but the overall theme remains clearly mitochondrial in nature.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015709","count":9},{"id":"GO:0097274","count":9},{"id":"GO:1990616","count":9},{"id":"GO:0046902","count":9},{"id":"GO:0035435","count":9}]},{"hash":"667998466603164762","title":"Neuronal synapse formation and plasticity","description":"Top GO terms indicate a coherent theme around neuronal connectivity, including axonal fasciculation, NMDA receptor clustering, long-term and structural synaptic plasticity, and synapse formation/regulation, with some support from calcium signaling and ubiquitination processes. This points to a cluster of proteins involved in establishing and modifying synaptic connections in neurons.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":5},{"id":"GO:0032237","count":4},{"id":"GO:0097114","count":4},{"id":"GO:1900044","count":4},{"id":"GO:0048170","count":4}]},{"hash":"833329963304790989","title":"Embryonic organogenesis","description":"Most terms point to embryonic development and organ formation (pancreas, skeletal, palate, gonad, neural tube, in utero development, multicellular development). This suggests the cluster comprises proteins involved in embryogenesis and organogenesis. The inclusion of translation reinitiation and GTPase regulatory processes may reflect broader regulatory roles during development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0008584","count":2}]},{"hash":"1002794908690382152","title":"Unknown","description":"The top GO terms span ER protein folding and calcium homeostasis, immune signaling, neuronal and hair follicle development, and chromosome cohesion maintenance, with zero edges linking proteins, indicating no coherent single function for the cluster. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010745","count":2},{"id":"GO:0048820","count":2},{"id":"GO:0048496","count":2},{"id":"GO:0034975","count":1},{"id":"GO:0032469","count":1}]},{"hash":"1341234197617679477","title":"Neural development and synaptic organization","description":"The cluster\u2019s top GO terms point to neural development (retina development, broader developmental processes) and synaptic regulation (synapse organization, receptor internalization), with supporting lipid-related processes (cholesterol biosynthesis, diacylglycerol catabolism) and APP metabolic activity. Together these suggest a group of proteins involved in neural development and maintenance of synaptic function through membrane dynamics and signaling, rather than a single non-neural pathway. Confidence: Medium","confidence":"","size":16,"edges":118,"triangles":532,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002076","count":12},{"id":"GO:0002087","count":12},{"id":"GO:0060041","count":12},{"id":"GO:0019441","count":7},{"id":"GO:0048789","count":7}]},{"hash":"554454766816413091","title":"Ubiquitination Pathways and NF-\u03baB Signaling","description":"This cluster is dominated by GO terms related to ubiquitination (protein and histone ubiquitination, autoubiquitination, various linkage types like K6, K63, and linear) and includes signals tied to NF-\u03baB activation and TNF-mediated pathways, suggesting a cohesive group of ubiquitin-regulated signaling and chromatin modification activities.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051865","count":9},{"id":"GO:0042787","count":9},{"id":"GO:0085020","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0036205","count":8}]},{"hash":"1874584914641669704","title":"Endocrine Hormone Secretion and Vascular Regulation","description":"Based on GO terms, the proteins appear to be involved in hormone secretion (corticotropin/ACTH, growth hormone, corticosterone), cAMP signaling, and production or regulation of vascular factors (VEGF) that influence blood pressure. This suggests a cohesive theme of endocrine control of vascular function rather than a single cellular process. Some items like visual perception and organ identity are present but are peripheral to the dominant endocrine-vascular signaling theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051458","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0048496","count":1},{"id":"GO:0006171","count":1},{"id":"GO:0010573","count":1}]},{"hash":"1193737052215088543","title":"Neural and Sensory Organ Development","description":"The top GO terms predominantly point to development and differentiation of neural and sensory tissues: cerebellar granule cell differentiation, dorsal spinal cord development, inner ear development, olfactory placode formation, and sensory perception of touch. Additional items like aorta smooth muscle morphogenesis and endochondral ossification reflect broader developmental processes rather than a single pathway. Some terms about cell wall/macromolecule and methanol catabolism seem less related and could be noise, but the central trend supports neural/sensory tissue development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060414","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0001958","count":3},{"id":"GO:0050975","count":3},{"id":"GO:0016998","count":3}]},{"hash":"191820550283517752","title":"Unknown","description":"The GO terms span immune signaling (IL-12 regulation, NOD1 pathway, MIP-1 alpha production), neural/lymphoid development (dendrite development, follicular dendritic cell differentiation), stress and hormone signaling (heat response, salicylic acid signaling), cell cycle regulation, and even heart morphogenesis, with no single cohesive function or pathway tying them together. The lack of network edges and the diversity of processes suggest no clear functional theme for this cluster. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045083","count":3},{"id":"GO:0070427","count":3},{"id":"GO:2000171","count":3},{"id":"GO:0071642","count":3},{"id":"GO:1904908","count":3}]},{"hash":"82074608759099958","title":"Developmental and Immune Signaling","description":"This cluster combines developmental processes (skeletal system, heart, multicellular organism development) with immune signaling (innate immunity, B cell signaling, neutrophil clearance, KIT pathway), suggesting a theme of coordinated development and immune regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001501","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0010863","count":4}]},{"hash":"12281192514705526","title":"Axon Guidance and Neural Development","description":"The top GO terms cluster around axon fasciculation, axon extension, and synapse assembly, with corpus callosum development and neural connectivity features, indicating a neural development and wiring theme. Some terms are broader developmental processes, but the predominant signal is axonal growth and neural wiring.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":4},{"id":"GO:0048846","count":3},{"id":"GO:0048681","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1126866091853638129","title":"Neural development and sensory organ formation","description":"This cluster is driven by terms related to neural development and sensory organ formation: ear development, otic placode development, facial nerve structural organization, sympathetic neuron projection guidance, and axon guidance signals. Supporting terms include hepatocyte growth factor receptor signaling (which can influence developmental cell migration) and angiogenesis during vascular morphogenesis, reflecting broader developmental remodeling. Some terms, like circadian rhythm and PAR-based ATP generation, are less clearly connected. Overall, the proteins likely participate in neural development and sensory structure formation. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990966","count":2},{"id":"GO:0042748","count":1},{"id":"GO:0097491","count":1},{"id":"GO:0048012","count":1},{"id":"GO:0043583","count":1}]},{"hash":"25360959480025094","title":"Unknown","description":"The GO terms are highly diverse, including DNA integration, vesicle fusion, sebaceous gland development, protein post-translational modifications, stress/heat responses, sperm motility, and axon extension regulation. There isn't a single unifying function that ties these terms together, so the cluster is best labeled Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0042144","count":1},{"id":"GO:0048733","count":1},{"id":"GO:0018230","count":1},{"id":"GO:0006950","count":1}]},{"hash":"1938493876038023297","title":"Developmental signaling and immune regulation","description":"These terms cluster around developmental signaling (CNS development, heart formation, Wnt signaling) with concurrent immune regulation (NOD signaling, IL-12 production, MIP-1\u03b1 production). While diverse, the common thread is signaling pathways that govern development and modulate immune responses.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048549","count":2},{"id":"GO:0007417","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0060914","count":1},{"id":"GO:0045083","count":1}]},{"hash":"1685670458068748495","title":"Diverse carbohydrate and cofactor metabolism","description":"The GO terms span broad metabolic activities, including carbohydrate processing (glycolytic steps, lactose catabolism, carbohydrate phosphorylation), nucleotide/salvage pathways (AMP and adenosine salvage, dATP biosynthesis), and cofactor biosynthesis (phylloquinone and menaquinone). This suggests a cluster of proteins involved in multiple, diverse metabolic pathways rather than a single, cohesive function. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042372","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0061615","count":1},{"id":"GO:0044209","count":1},{"id":"GO:0006169","count":1}]},{"hash":"79859227308058945","title":"Ciliogenesis and cell division","description":"The top GO terms point to cilium-related functions (cilium assembly) with a link to visual perception, implying a photoreceptor/ciliary context. At the same time, strong signals for mitotic cell cycle and cell division indicate the cluster also centers on proliferation-related processes. Additional terms like Ran signaling and regulation of GTPase activity fit with ciliary trafficking and cytoskeletal dynamics during division, supporting a cohesive theme of cilia-associated signaling intersecting with cell cycle control.","confidence":"Medium","size":15,"edges":99,"triangles":386,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":12},{"id":"GO:0000278","count":12},{"id":"GO:0043547","count":12},{"id":"GO:0002098","count":11},{"id":"GO:0035330","count":11}]},{"hash":"1789178151641996352","title":"Chromatin remodeling and heterochromatin formation","description":"The cluster is dominated by GO terms for chromatin remodeling, heterochromatin formation (pericentric and rDNA), nucleosome density and positioning, and negative regulation of transcription by RNA polymerase II, indicating proteins that regulate chromatin structure to repress transcription. The presence of multiple heterochromatin-related terms (with supporting transcriptional regulation terms) supports a cohesive role in chromatin-based transcription control.","confidence":"High","size":15,"edges":57,"triangles":120,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0060303","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0043044","count":7},{"id":"GO:0000183","count":6}]},{"hash":"1057974360930115619","title":"Potassium Transport and Membrane Excitability","description":"This cluster is driven by potassium-related processes: potassium ion transmembrane transport, intracellular potassium ion homeostasis, and multiple aspects of membrane potential dynamics (stabilization, hyperpolarization, repolarization). Together these imply proteins that regulate cellular excitability, such as potassium channels and regulatory components. The presence of sensory-related terms (pain, mechanosensation) suggests neural signaling connections, but the central theme remains potassium handling and membrane potential control.","confidence":"High","size":15,"edges":17,"triangles":5,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071805","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0030007","count":5},{"id":"GO:0030322","count":5}]},{"hash":"974917556084191130","title":"Cardiac and Skeletal Muscle Contractile Regulation and Development","description":"This cluster is dominated by GO terms tied to heart and skeletal muscle contraction and their regulation (positive regulation of force of heart contraction; regulation of cardiac muscle contraction via calcium release; ventricular muscle morphogenesis; skeletal muscle fiber development; detection of calcium ion). The emphasis on Ca2+-dependent contraction and muscle development suggests a cohesive theme of muscle contraction regulation across cardiac and skeletal tissues, with a few outliers (kidney development, memory) likely peripheral. Confidence in this label is High.","confidence":"","size":15,"edges":72,"triangles":165,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098735","count":12},{"id":"GO:0010881","count":12},{"id":"GO:0048741","count":12},{"id":"GO:0005513","count":12},{"id":"GO:0072221","count":12}]},{"hash":"1737111785588941652","title":"Detoxification and stress-response signaling","description":"This cluster centers on detoxification of oxidants and xenobiotics (cellular oxidant detoxification, xenobiotic catabolic process) and associated stress-response signaling (ERK cascade regulation, p53-mediated DNA damage response, responses to growth factors and LPS), indicating a cohesive theme of antioxidant defense coupled with stress- and immune-related signaling.","confidence":"Medium","size":15,"edges":67,"triangles":220,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0098869","count":12},{"id":"GO:0043517","count":11},{"id":"GO:2000469","count":11},{"id":"GO:0071364","count":11},{"id":"GO:0042178","count":11}]},{"hash":"565134007040916251","title":"Steroid hormone biosynthesis and catabolism","description":"The top GO terms are dominated by steroid-related processes: estrogen biosynthetic process, androgen catabolic process, and steroid catabolic process, indicating a core focus on steroid hormone metabolism. While there are additional metabolism terms (retinal, sphingolipid-related), the recurring theme centers on synthesis and breakdown of steroid hormones, justifying the label.","confidence":"High","size":15,"edges":20,"triangles":5,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0030324","count":11},{"id":"GO:0045150","count":11},{"id":"GO:0042619","count":11},{"id":"GO:0006729","count":11}]},{"hash":"476958559937278434","title":"Neural development and brain regionalization","description":"The cluster centers on nervous system formation, with terms like neuromuscular process, telencephalon regionalization, diencephalon morphogenesis, peripheral nervous system neuron development, and somite specification, indicating a cohesive theme of neural development and CNS patterning. Some terms (e.g., somite specification) may reflect broader developmental processes but are still compatible with neural patterning contexts.","confidence":"High","size":15,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050905","count":2},{"id":"GO:0060929","count":2},{"id":"GO:1900212","count":2},{"id":"GO:0021978","count":2},{"id":"GO:0048852","count":2}]},{"hash":"864777786679811794","title":"Hedgehog-mediated neurodevelopment and organogenesis","description":"The cluster centers on nervous system development and Hedgehog (Smoothened) signaling, with strong links to neurogenesis, myelination, and heart/kidney development, suggesting a cohesive role in neural development and organ formation. Vesicle fusion and myoblast differentiation terms further support developmental maturation; a plant-related term may reflect annotation noise.","confidence":"High","size":15,"edges":77,"triangles":223,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":13},{"id":"GO:0007224","count":11},{"id":"GO:0001822","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0042552","count":8}]},{"hash":"358052475905953451","title":"Embryogenesis and organogenesis","description":"This cluster aggregates proteins linked to broad developmental processes across multiple organs: nervous system development (peripheral NS, trigeminal ganglion, retinal axon guidance), pituitary and endocrine gland development, primitive streak formation, ureteric bud branching morphogenesis, and digestive tract morphogenesis. The inclusion of negative regulation of transcription by RNA polymerase II suggests regulatory factors coordinating gene expression during these developmental events. Overall, these terms point to a common theme of embryonic development and organ formation.","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0021983","count":7},{"id":"GO:0048935","count":6},{"id":"GO:0090009","count":6},{"id":"GO:0048557","count":5}]},{"hash":"202776519720877173","title":"Chloroplast photorespiration and biosynthetic pathways","description":"The cluster is driven by photorespiration and oxidative photosynthetic carbon pathway terms, indicating chloroplast/peroxisomal plant metabolism. Additional GO terms for isoprenoid biosynthesis, porphyrin precursor biosynthesis, and vitamin/cofactor (biotin) and amino acid (lysine) biosynthesis point to a broader set of chloroplast-associated biosynthetic processes tied to photosynthetic carbon flux and related metabolic routes.","confidence":"Medium","size":15,"edges":21,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009854","count":4},{"id":"GO:0009853","count":4},{"id":"GO:0008299","count":4},{"id":"GO:0019516","count":4},{"id":"GO:0046296","count":4}]},{"hash":"1136482770288038998","title":"Embryonic organogenesis and tissue morphogenesis","description":"The top GO terms cluster around developmental processes across multiple tissues\u2014pancreas development, cartilage morphogenesis, endocrine system development, placental/trophoblast differentiation, left-right patterning, EMT in heart formation, and cardiac muscle differentiation\u2014indicating a general theme of embryonic organogenesis and tissue morphogenesis rather than a single pathway.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":5},{"id":"GO:0060536","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060972","count":4}]},{"hash":"1278323116304123473","title":"Ribosome biogenesis and translation initiation","description":"The cluster's top GO terms are dominated by translation-related processes: translation, translational initiation, translation reinitiation, formation of translation preinitiation complex, and maturation of SSU rRNA, which together point to ribosome assembly and the initiation/early steps of protein synthesis. A few mRNA processing terms and development term appear as secondary signals but do not override this central theme.","confidence":"High","size":15,"edges":76,"triangles":196,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0006397","count":2},{"id":"GO:0006378","count":2}]},{"hash":"2242381047028076534","title":"miRNA-Mediated Silencing and mRNA Regulation","description":"Top terms cluster around regulatory ncRNA- and miRNA-mediated gene silencing and processes affecting mRNA stability/localization (e.g., poly(A) tail shortening and oskar mRNA localization), indicating a shared theme of post-transcriptional gene regulation through RNA interference pathways. Some developmental and inflammatory terms appear as broader contextual annotations rather than core signals of the cluster.","confidence":"Medium","size":15,"edges":55,"triangles":88,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":4},{"id":"GO:0035278","count":4},{"id":"GO:0006468","count":3},{"id":"GO:0045451","count":3},{"id":"GO:0060213","count":3}]},{"hash":"1115850095517614113","title":"Heart and Brain Development under Hypoxic Stress","description":"The top GO terms include heart development, brain development, and cardiac muscle hypertrophy in response to stress, alongside cellular response to hypoxia, pointing to a shared theme of cardiac and neural development with adaptive responses to low oxygen. Additional terms on mRNA transport and GTPase regulation suggest broader regulatory support for these developmental and stress-response processes. Overall, the label reflects the dominant tissue development and hypoxia-adaptation signals in the cluster.","confidence":"Medium","size":15,"edges":15,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0043547","count":3},{"id":"GO:2001015","count":2},{"id":"GO:0033234","count":2}]},{"hash":"1509093214765544646","title":"Antiviral Innate Immunity and MHC I Regulation","description":"The cluster centers on antiviral defense and innate immunity (defense response to virus, innate immune response, RIG-I signaling) with involvement in antigen presentation (positive regulation of MHC class I biosynthetic process). Additional terms suggest cytokine modulation (negative regulation of IL-6), control of viral material transport, and post-translational regulatory processes (autoubiquitination) and RNA silencing, indicating coordinated antiviral sensing and MHC I\u2013mediated antigen presentation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0045345","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0032715","count":2},{"id":"GO:1901536","count":1}]},{"hash":"553115315214554734","title":"Embryonic development and organ morphogenesis","description":"The terms point to morphogenesis and development across diverse tissues (cartilage, placenta/trophoblast, endocrine pancreas, hair follicles, heart EMT, left-right patterning), suggesting a cluster of proteins involved in broad embryonic tissue morphogenesis and organ development. A couple of general cellular processes (mRNA splicing, DNA replication initiation) may accompany these developmental roles. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":12},{"id":"GO:0060707","count":12},{"id":"GO:0035270","count":12},{"id":"GO:0003323","count":12},{"id":"GO:0060806","count":12}]},{"hash":"1659195656919793593","title":"Complement and Coagulation with Platelet Activation","description":"The dominant GO terms point to immune-coagulation processes: complement activation (classical and alternative), blood coagulation, and positive regulation of platelet activation, with integrin and Rho signaling linking adhesion and cytoskeletal changes. This suggests a cohesive cluster centered on thromboinflammatory immune responses involving complement and platelet function, despite a few broader signals like synapse assembly. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001970","count":4},{"id":"GO:0006924","count":3},{"id":"GO:0033623","count":3},{"id":"GO:0010572","count":3},{"id":"GO:0035023","count":3}]},{"hash":"285003470786174338","title":"Thermal and Cardiovascular Signaling","description":"This cluster centers on temperature/pain-related GO terms (diet-induced thermogenesis, cellular response to temperature stimulus, sensory perception of pain) and includes signaling-related terms (GTPase activity regulation, cAMP signaling, adenylate cyclase activation) plus cardiovascular-associated processes (platelet activation, heart development) and protein phosphorylation. The common thread is proteins involved in signaling cascades that mediate thermal/pain responses and cardiovascular regulation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0001975","count":5},{"id":"GO:0043547","count":5}]},{"hash":"2124360354378071463","title":"Neurovascular development and immune signaling","description":"This cluster is enriched for forebrain development, angiogenesis, and integrin/PDGF receptor signaling, with additional terms related to transcytosis and immune processes (B cell differentiation, IL-7 response, Fc receptor signaling). The combination suggests proteins involved in neural vascular development and immune signaling cross-talk rather than a single isolated function. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030900","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007229","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0010641","count":3}]},{"hash":"2286449450161664416","title":"Cardiovascular and neural development","description":"The top GO terms point to morphogenesis and regulation in heart and blood vessels (ventricular cardiac muscle tissue morphogenesis, branching in blood vessel morphogenesis, regulation of heart contraction) and to development of Schwann cells, plus neural activity (short-term memory, synaptic potentiation). This suggests a broad theme of developmental and functional processes spanning cardiovascular and nervous system tissues, so this label captures the main shared context.","confidence":"Medium","size":15,"edges":27,"triangles":16,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055010","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0097274","count":4},{"id":"GO:0007614","count":4},{"id":"GO:2001015","count":4}]},{"hash":"780138714955742188","title":"Rho GTPase signaling and cytoskeletal dynamics","description":"The most represented GO terms point to Rho-regulated signaling, actin-based microspike assembly, and cytoskeletal morphogenesis, with additional links to endocytosis and membrane remodeling; together these suggest a module of Rho-driven cytoskeletal remodeling often coupled to membrane trafficking.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0030035","count":3},{"id":"GO:1903527","count":3},{"id":"GO:0007032","count":2},{"id":"GO:0090307","count":2}]},{"hash":"2240532185435024613","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":7,"triangles":2,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0032968","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0006406","count":3}]},{"hash":"1386549037810509415","title":"Muscle and cardiac differentiation regulators","description":"This cluster is dominated by GO terms tied to muscle development (positive regulation of myoblast differentiation, myoblast fusion) and cardiac development (right ventricle formation), along with circadian regulation of gene expression and transcriptional control, indicating a regulatory program that coordinates differentiation in muscle and heart tissues. While there are outliers such as humoral immune response and neuronal differentiation, the strongest signal centers on muscle/heart differentiation and the transcriptional regulation underpinning these processes. The combination suggests a cohesive theme of regulatory factors guiding development in muscle and cardiac contexts, with broader roles in transcriptional control. ","confidence":"Medium","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0043433","count":9},{"id":"GO:0045663","count":8},{"id":"GO:0045668","count":8},{"id":"GO:0006959","count":8}]},{"hash":"163334027309816480","title":"Developmental signaling and morphogenesis","description":"The cluster shows GO terms tied to signaling pathways (ERK cascade, Hedgehog Smoothened, Roundabout) and development-related processes (neuron migration, axon guidance, angiogenesis, ossification, kidney development). Together they point to signaling-driven morphogenesis across tissues, rather than a single specific function. Innate immunity terms add breadth but the primary theme remains developmental signaling and tissue formation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0001764","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007224","count":2}]},{"hash":"317171200041581993","title":"Growth Factor Signaling and Stress Response","description":"The terms cluster around cellular responses to growth factor\u2013related stimuli\u2014insulin and epidermal growth factor\u2014as well as downstream signaling such as ERK cascades, and include elements of stress responses like DNA damage signaling and transcriptional regulation. While there are also miscellaneous terms (interferon response, xenobiotic metabolism), the dominant theme is signaling activation by growth factors and associated transcriptional changes, justifying a Growth Factor Signaling and Stress Response label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043517","count":1},{"id":"GO:0071346","count":1},{"id":"GO:2000469","count":1}]},{"hash":"1569982420127052577","title":"Cardiac signaling and transcription regulation","description":"The top GO terms show a mix of transcription-related processes (DNA-templated transcription, transcription regulation) and signaling pathways linked to cardiac function (regulation of heart rate, cardiac muscle cell proliferation, cellular response to cGMP, positive regulation of adenylate cyclase activity). While there are also terms related to immune signaling and other processes, the convergence on transcription control plus heart/second messenger signaling suggests a cluster centered on cardiac signaling and transcriptional regulation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0046580","count":3},{"id":"GO:0002027","count":3},{"id":"GO:0045013","count":3},{"id":"GO:0046007","count":3}]},{"hash":"1820872154374990737","title":"Golgi SNARE vesicle trafficking in neurons","description":"The terms center on Golgi and vesicle transport, SNARE complex assembly, and receptor trafficking at synapses, including ER-to-Golgi and intra-Golgi transport, Golgi ribbon formation, and exocytic insertion of neurotransmitter receptors linked to synaptic potentiation. This suggests a cohesive neuron-specific vesicle trafficking role governed by Golgi pathways and SNARE machinery.","confidence":"High","size":15,"edges":11,"triangles":4,"max_degree":5,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0060291","count":6},{"id":"GO:1903358","count":6},{"id":"GO:0048280","count":5},{"id":"GO:0090161","count":5}]},{"hash":"505757574716515672","title":"Unknown","description":"The GO terms span transcription regulation, actin cytoskeleton dynamics, spindle organization, vesicle transport along actin, and diverse developmental and sensory processes, with no clear shared function tying all proteins together.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:1903480","count":1},{"id":"GO:0048496","count":1},{"id":"GO:0050957","count":1},{"id":"GO:0021873","count":1}]},{"hash":"1227521751532035776","title":"Fungal pseudohyphal/invasive growth and secretion","description":"The dominant GO terms cluster around fungal morphogenesis under nutrient stress, notably pseudohyphal growth and invasive growth in response to glucose limitation, indicating a yeast/fungal filamentation program. Supporting processes include secretion and trafficking (ER exit, localization to the cell surface, secretion of enzymes), suggesting coordinated growth with protein trafficking. Some terms are peripheral (e.g., DNA integration), but the core theme aligns with growth and secretion in a nutrient-limited fungal context.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0070863","count":1},{"id":"GO:0001403","count":1},{"id":"GO:0007124","count":1},{"id":"GO:0061060","count":1}]},{"hash":"1439732812225634929","title":"Cell-cycle regulation and stress response","description":"These GO terms cluster around cell-cycle control and transcription/replication activities (mitotic cell cycle, DNA-templated transcription, positive regulation of DNA-templated DNA replication initiation, and nuclear export), together with stress/defense responses (innate immune response, response to toxic substances, cadmium ion). This suggests a role in coordinating cell-cycle progression with transcriptional responses under stress, rather than a single tight pathway. The development-related terms (mesoderm formation, budding cell apical bud growth) may reflect broader annotation or cross-talk across species. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0032298","count":2}]},{"hash":"1458834268219642831","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":2},{"id":"GO:0031497","count":1},{"id":"GO:0006335","count":1},{"id":"GO:0010026","count":1},{"id":"GO:0009934","count":1}]},{"hash":"1596869213845731867","title":"Embryonic organogenesis: heart and cartilage","description":"The Top GO terms cluster around embryonic development, especially processes tied to heart formation (endocardial cushion EMT, left-right patterning) and cartilage morphogenesis, with additional embryo development terms like placental and endocrine/pancreatic differentiation. This suggests a cohesive theme of embryonic tissue/organogenesis, particularly heart and cartilage.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060806","count":4}]},{"hash":"27522101636258183","title":"Ciliary motility and microtubule remodeling","description":"The top GO terms point to cilia/flagella movement (epithelial cilium movement, flagellated sperm motility) and cytoskeletal regulation (microtubule severing, regulation of axon extension), suggesting these proteins cluster around ciliary motility and microtubule dynamics. A few other terms (glycosylation, DNA integration) appear less connected and may reflect annotation noise, but the central theme remains ciliary/flagellar function and microtubule remodeling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006486","count":2},{"id":"GO:0005975","count":1},{"id":"GO:0036065","count":1},{"id":"GO:1905419","count":1}]},{"hash":"1744532898340776427","title":"RNA splicing and translation regulation","description":"Most terms point to RNA processing and translation control: spliceosome-mediated mRNA splicing and alternative splicing regulation; ribosome biogenesis and preinitiation complex formation; regulation of translational initiation and reinitiation, including IRES/viral initiation. A stress-related mRNA stability term ties in with cellular stress responses. Taken together, these proteins likely function in coordinating RNA processing with the initiation of translation, especially under stress or growth conditions.","confidence":"High","size":14,"edges":10,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0010610","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0006446","count":2}]},{"hash":"1647070679878899288","title":"Steroid and lipid hormone metabolism","description":"Most top GO terms cluster around metabolism of steroids and lipids: estrogen biosynthesis, androgen catabolic processes, sphinganine lipid metabolism, retinal (retinoid) metabolism, and tetrahydrobiopterin biosynthesis which supports hydroxylase activities involved in steroid metabolism. The presence of a lung development term may reflect retinoid signaling roles in lung development, while some terms (acetoin catabolism, poly-hydroxybutyrate biosynthesis) appear as outliers. Overall, the group seems best described by steroid and lipid metabolism processes.","confidence":"Medium","size":14,"edges":41,"triangles":40,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0030324","count":12},{"id":"GO:0045150","count":12},{"id":"GO:0042619","count":12},{"id":"GO:0006729","count":12}]},{"hash":"521617058996618221","title":"Stress and Immune Signaling","description":"This cluster centers on stress-related and immune signaling processes (amino acid starvation response, osmosensory signaling, innate immune response, NF-kappaB regulation), with additional links to differentiation, apoptosis, and neuronal development, suggesting a broad signaling module activated under stress and immune contexts rather than a single pathway.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0034198","count":5},{"id":"GO:0042220","count":4},{"id":"GO:0071226","count":4},{"id":"GO:0014902","count":4}]},{"hash":"648957037288095998","title":"Temperature-sensing pain signaling and immune regulation","description":"The top GO terms concentrate on temperature response and pain perception, with regulatory aspects of pain signaling and cytokine production, plus acetylcholine metabolism and blood pressure. This points to a neuroimmune axis linking thermal/pain signaling with autonomic and inflammatory regulation, even though the cluster also includes some photoreceptor maintenance signals. Confidence: Medium","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0051930","count":13},{"id":"GO:0090198","count":13}]},{"hash":"2099036245543231390","title":"GPCR-cAMP/cGMP Signaling","description":"This cluster is dominated by GO terms pointing to G protein-coupled receptor signaling and downstream cyclic nucleotide second messenger production, including cAMP and cGMP biosynthesis, and related pathways (adenylate cyclase-activating and guanylyl cyclase signaling). The presence of GPCR-mediated adenosine and adrenergic signaling terms and intracellular signal transduction supports a cohesive GPCR signaling theme, despite some obsolete terms and lack of network edges.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006171","count":9},{"id":"GO:0030828","count":9},{"id":"GO:0052565","count":9},{"id":"GO:0007168","count":9},{"id":"GO:0006182","count":9}]},{"hash":"1968981373928415552","title":"Mesodermal Development and Angiogenesis","description":"The top GO terms cluster around mesoderm formation, angiogenesis, and myotube differentiation, suggesting a shared role in mesodermal development and muscle/vascular differentiation, supported by signaling responses and extracellular remodeling indicators (peptide hormone signaling, phorbol ester response, metallopeptidase activity).","confidence":"Medium","size":14,"edges":50,"triangles":78,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001707","count":14},{"id":"GO:0007118","count":14},{"id":"GO:1905050","count":14},{"id":"GO:0042220","count":14},{"id":"GO:0071375","count":14}]},{"hash":"1482247517146267130","title":"Neuronal signaling and synaptic plasticity regulation","description":"The terms point to neuronal signaling and plasticity, with emphasis on dopaminergic/amphetamine response, regulation of synaptic plasticity, calcium mobilization, and cAMP signaling (adenylate cyclase activation). Positive regulation of GTPase activity and protein phosphorylation further support modulation of signaling and synaptic function, while other terms like heart development may reflect shared developmental pathways; overall the cluster centers on neuronal signaling regulation rather than a non-neuronal process. ","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0048168","count":2}]},{"hash":"769436850546831172","title":"Vascular remodeling and neural guidance","description":"This cluster shows a coherent theme around developmental remodeling of tissues, especially vasculature and neural pathways, with terms like sprouting angiogenesis, axon guidance, anatomical structure organization, and vascular smooth muscle contraction. Related signaling and growth control terms (e.g., CAMKK-AMPK regulation, protein catabolic regulation) support a broader developmental regulation context. ","confidence":"High","size":14,"edges":16,"triangles":6,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1905289","count":14},{"id":"GO:0032889","count":14},{"id":"GO:0048532","count":14},{"id":"GO:0090051","count":14},{"id":"GO:0007411","count":14}]},{"hash":"1899957739683003203","title":"Host Stress-Driven Inflammatory Signaling","description":"The terms cluster around stress response and inflammation (inflammatory response; regulation of IL-1 beta and TNF signaling; NF-kappaB activity) plus hormonal regulation (cortisol biosynthesis) and metabolic signaling (insulin response). This suggests a coordinated host response integrating stress signaling, immune/inflammatory pathways, and hormonal modulation, with a possible context of host-symbiont interaction (dormancy entry of symbiont in host). Hence a theme of stress-induced inflammatory and hormonal signaling.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":4},{"id":"GO:0006950","count":4},{"id":"GO:0032868","count":2},{"id":"GO:0032651","count":2},{"id":"GO:0010803","count":2}]},{"hash":"1308040872128558973","title":"mRNA splicing and processing regulation","description":"The proteins cluster around post-transcriptional RNA processing, dominated by mRNA splicing via the spliceosome and its regulation, including both positive and negative control of splicing, along with related processes like alternative splicing, mRNA modification, and mRNA stability in response to stress. The presence of terms spanning splicing, regulation, and RNA processing suggests a cohesive group involved in RNA maturation and gene expression control after transcription.","confidence":"High","size":14,"edges":84,"triangles":287,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":11},{"id":"GO:0010610","count":10},{"id":"GO:0002188","count":10},{"id":"GO:0048025","count":10},{"id":"GO:1901407","count":10}]},{"hash":"915047613782128781","title":"Neurovascular development and axon guidance","description":"These proteins cluster around processes that couple vessel formation with neural development, as shown by angiogenesis and paraxial mesoderm development terms alongside motor neuron axon guidance and paranode localization. VEGF/PDGF signaling and actin cytoskeleton regulation suggest coordinated morphogenesis and cell polarity, while the innate immune signal may be a secondary facet. Overall, the theme centers on coordinated neural-vascular development and axon pathfinding.","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0048339","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0002318","count":2},{"id":"GO:0038091","count":2},{"id":"GO:2000249","count":2}]},{"hash":"187223110564919577","title":"Embryonic development and organ morphogenesis","description":"This cluster is best described as Embryonic development and organ morphogenesis because the majority of GO terms relate to tissue formation, differentiation, and patterning during embryogenesis (cartilage morphogenesis, left-right pattern formation, placental and heart cushion EMT, Sertoli and pancreatic cell development, endocrine system development). A single term about mRNA splicing is a general cellular process supporting these programs. The overarching theme is developmental morphogenesis rather than a single molecular function.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003323","count":2}]},{"hash":"2245269672811231703","title":"Neuronal development and synaptic signaling regulation","description":"The proteins cluster around neuronal maturation and connectivity, with GO terms for dendrite development, dendritic spine formation, and hippocampus development, indicating neurite outgrowth and brain-region-specific maturation. They also show regulation of synaptic signaling (dopamine uptake) and signaling cascades (ERK1/2), supporting a cohesive theme of neuronal development coupled with synaptic regulation. Some terms like cell division are less central, but the dominant pattern points to a neuron-focused development/synaptic function module.","confidence":"High","size":14,"edges":4,"triangles":1,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0034498","count":4},{"id":"GO:0051586","count":4},{"id":"GO:0060999","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0070374","count":4}]},{"hash":"1764937153567500157","title":"Axon guidance and neural development","description":"The top GO terms are strongly centered on neural development and axon guidance, including axon guidance itself, Roundabout signaling, nervous system development, and Hedgehog-related signaling (Smoothened). ERK cascade regulation and Kv channel clustering also fit neuronal signaling contexts, supporting a theme of neural wiring and signaling during development. Some terms like corticosterone response, kidney development, and mast cell chemotaxis may reflect broader signaling roles or pleiotropy, but the dominant signal points to neural development and axon guidance.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0051412","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0001822","count":3}]},{"hash":"1980182386247320566","title":"Embryonic development and epithelial differentiation signaling","description":"The terms point to developmental processes and signaling in epithelia (keratinocyte differentiation, mesoderm formation, budding), with key regulatory pathways (Wnt, Hippo) and transcriptional control, plus apoptosis, suggesting a cohesive role in embryonic development and epithelial tissue differentiation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030216","count":10},{"id":"GO:0090263","count":10},{"id":"GO:0060044","count":10},{"id":"GO:0000186","count":10},{"id":"GO:0006935","count":10}]},{"hash":"396127348961554794","title":"Neuronal synaptic signaling and plasticity","description":"The terms cluster around synapse formation, maintenance, and signaling, including long-term synaptic depression, dendritic spine maintenance, actin remodeling at synapses, and regulation of neurotransmitter release. These collectively point to neuronal communication and plasticity as the core function, with some terms touching on broader secretion or differentiation that are less central to neurons. Overall, the cluster represents neural synaptic signaling and plasticity.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0034316","count":3},{"id":"GO:0014902","count":3},{"id":"GO:0051965","count":3}]},{"hash":"187710076090520392","title":"Embryonic organogenesis and neurodevelopment","description":"This cluster's top GO terms span retina development, cerebral cortex regionalization, spinal cord neuron differentiation, pituitary gland development, embryonic cranial skeleton morphogenesis, ureteric bud branching morphogenesis, and broader multicellular organism development. The common thread is participation in early developmental programs and morphogenesis across multiple tissues, with a notable emphasis on neural development. This suggests proteins are tied to embryonic organogenesis and neurodevelopment rather than a single tissue-specific pathway.","confidence":"High","size":14,"edges":46,"triangles":40,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":8},{"id":"GO:0021983","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0003309","count":7},{"id":"GO:0021912","count":6}]},{"hash":"1443456577517484317","title":"Neuronal mechanosensing and synaptic remodeling","description":"This cluster centers on sensory/mechanical stimulus detection (nociception and mechanosensation), cellular responses to mechanical cues, and dendritic spine morphogenesis, all pointing to neuronal signaling and structural plasticity. GPCR signaling and ubiquitination support regulation of signaling and trafficking in neurons, while insulin-related responses and mitochondrial changes are ancillary metabolic and apoptotic aspects that can occur in neuronal contexts. Overall, the dominant theme is neuronal signaling and remodeling in response to mechanical and sensory inputs.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0050968","count":2},{"id":"GO:0016477","count":2}]},{"hash":"2144458323863457451","title":"Unknown","description":"Top terms are heterogeneous across dormancy, stress response, RNA regulation, and diverse developmental processes, with no cohesive shared function or pathway tying the proteins together; no edges indicate a lack of functional connectivity, so a reliable label cannot be assigned.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":1},{"id":"GO:0006950","count":1},{"id":"GO:0080009","count":1},{"id":"GO:0061157","count":1},{"id":"GO:0030708","count":1}]},{"hash":"59924277664451057","title":"Neural endocytosis and synaptic vesicle trafficking","description":"This cluster centers on endocytic processes and vesicle transport, including endocytosis, endosome maturation, and regulation of synaptic vesicle exocytosis, with neural-associated terms like brain development and neuromuscular balance supporting a neural context.","confidence":"High","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010796","count":6},{"id":"GO:0031384","count":5},{"id":"GO:0007420","count":5},{"id":"GO:2000300","count":5},{"id":"GO:0032456","count":4}]},{"hash":"771891284885043347","title":"Axon Guidance and Paranodal/Juxtaparanodal Organization","description":"Based on the GO terms, the cluster centers on neuronal pathfinding and the specialized organization of axon segments, including sympathetic and branchiomotor neuron guidance, along with paranodal and juxtaparanodal localization and assembly, suggesting a cohesive theme of axon guidance with axonal domain organization.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0097491","count":2},{"id":"GO:0030913","count":2},{"id":"GO:0097490","count":2},{"id":"GO:0002175","count":2}]},{"hash":"1237421720114338077","title":"Unfolded Protein Response","description":"The strongest signals are ER-stress\u2013driven responses: GO:0036494 (positive regulation of translation initiation in response to endoplasmic reticulum stress) and GO:0006986 (response to unfolded protein) point to activation of the unfolded protein response and proteostasis mechanisms. Although some terms are more disparate (e.g., development in striatum, photoreceptor organization, chlorophyll biosynthesis, LPS metabolism), the core theme centers on cellular stress response related to protein folding and ER stress, making this a reasonable high-level label.","confidence":"Medium","size":14,"edges":44,"triangles":81,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036494","count":4},{"id":"GO:0035955","count":4},{"id":"GO:0050689","count":4},{"id":"GO:0021756","count":4},{"id":"GO:0035845","count":4}]},{"hash":"1784409280668050555","title":"Transposon and proviral integration","description":"The top GO terms cluster around DNA movement and integration: DNA integration, DNA transposition, retrotransposition, DNA-templated transcription, and establishment of integrated proviral latency. These point to mobility of genetic elements and viral integration dynamics as the shared theme, with a few miscellaneous terms related to RNA processing or cellular regulation as outliers. Confidence: Medium","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0007182","count":2},{"id":"GO:0050765","count":2}]},{"hash":"704509882315602177","title":"Craniofacial and neural development signaling","description":"The top GO terms point to integrin signaling, VEGF production, neuron projection guidance, facial nerve organization, craniofacial morphogenesis, synapse maturation, and left-right heart asymmetry, suggesting a cohesive theme of developmental signaling guiding craniofacial, neural, and cardiovascular morphogenesis. Proteolysis and regulation of endothelial chemotaxis may reflect remodeling and vascular patterning during development, reinforcing a developmental morphogenesis-focused cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:0010573","count":1},{"id":"GO:0097491","count":1},{"id":"GO:0060468","count":1},{"id":"GO:0021612","count":1}]},{"hash":"1974849051629369240","title":"Unknown","description":"The GO terms are diverse (transcription, signaling, apoptosis, fertilization, aging, bone development) with some obsolete terms; there is no clear shared process linking all proteins, so Unknown is the most appropriate label.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0006915","count":2}]},{"hash":"240394037710714793","title":"Drug-response and locomotion behavior","description":"The GO terms cluster around behavioral responses to drugs (response to cocaine; regulation of response to drug) and movement/locomotion (adult walking behavior; locomotory behavior), suggesting a core theme of drug-responsive movement. Supporting terms related to cell adhesion and spreading hint at cellular processes that can influence tissue remodeling and neural connectivity involved in movement, while circadian regulation and amyloid-beta formation point to broader neural regulatory networks. Overall, the cluster appears to reflect behavioral and movement-related responses modulated by drug exposure and neural regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":3},{"id":"GO:0034446","count":2},{"id":"GO:0007628","count":2},{"id":"GO:0051919","count":2},{"id":"GO:0007155","count":2}]},{"hash":"438479662255170602","title":"Septin Ring Assembly and Bud Neck Localization","description":"The most represented GO terms are septin ring assembly, bud neck circumscription/organization, and protein localization to the bud neck, pointing to a cohesive group of proteins involved in septin-based cytoskeletal formation and targeting at the yeast/bud neck during cell division. Other terms appear less central and are likely incidental.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000921","count":3},{"id":"GO:0032186","count":3},{"id":"GO:0097271","count":3},{"id":"GO:0070535","count":2},{"id":"GO:0016558","count":2}]},{"hash":"1380932034761009940","title":"Synaptic signaling and plasticity regulators","description":"The cluster prominently features GO terms tied to neuronal communication and plasticity, including regulation of Rho and Ras signaling, IP3 biosynthesis, synapse assembly, and long-term potentiation. These together suggest a role in modulating synaptic signaling and plasticity, despite a few non-neuronal terms present (e.g., B cell differentiation, angiogenesis). This overall pattern points to neuronal signaling regulation as the core theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0046580","count":2},{"id":"GO:0032959","count":2},{"id":"GO:0007416","count":2},{"id":"GO:0060291","count":2}]},{"hash":"460330937756018753","title":"Sensory perception and membrane potential regulation","description":"The terms cluster around sensory modalities (pain, touch) and tissue development (skin), with a strong emphasis on ion homeostasis and membrane potential (potassium transport, resting potential, membrane repolarization). This points to a coherent theme of sensory tissue function linked to excitability, despite some developmental terms, suggesting a unified label focusing on sensory perception and membrane potential control.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0019233","count":6},{"id":"GO:0030007","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0043588","count":5}]},{"hash":"358266533931863092","title":"Ubiquitin-Dependent Proteostasis and Signaling","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, ERAD, and K6-linked ubiquitination) indicating regulation of protein turnover via ubiquitination. Additional terms touch on peroxisomal protein import and signaling pathways (NF-kappaB, JNK) and innate immunity, suggesting a broader theme of ubiquitin-mediated regulation of proteostasis and immune signaling. Some terms (neural tube closure, X chromosome inactivation) are less obviously connected but do not override the central ubiquitin-centric theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0016558","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0051092","count":3},{"id":"GO:0045087","count":3}]},{"hash":"685479845774227573","title":"Prostaglandin GPCR Cardiovascular Signaling","description":"This cluster centers on GPCR-mediated signaling related to prostaglandin response, heart and blood pressure regulation, and neural signaling (e.g., dopaminergic transmission), with supporting elements like GPCR internalization and GTPase activity. The strong emphasis on prostaglandin-triggered GPCR pathways and cardiovascular functions suggests a cohesive theme of GPCR-driven cardiovascular signaling, even though other terms (insulin signaling regulation, macrophage chemotaxis, mitochondrial processes) indicate broader connectivity.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0071380","count":4},{"id":"GO:0046626","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0010759","count":3}]},{"hash":"1321934968032194307","title":"Adrenergic GPCR-CAMP Signaling and Thermogenesis","description":"The top GO terms point to GPCRs that activate adenylate cyclase and raise cAMP, a classic pathway driving thermogenesis (diet-induced) and cardiovascular responses (blood pressure). Terms about temperature sensing and pain modulation fit into the broader autonomic signaling theme, while acetylcholine metabolism reflects neurotransmitter turnover in these pathways. Together they suggest an autonomic, adrenergic GPCR-cAMP signaling cluster linked to energy expenditure and vascular regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0007190","count":11},{"id":"GO:0002024","count":10}]},{"hash":"411984544606501328","title":"Bacterial cell wall biosynthesis and antibiotic production","description":"The top GO terms point to biosynthesis of antibiotics and cell envelope components (lipoteichoic acid), along with cell wall organization, indicating a coherent theme of bacterial cell wall biosynthesis and related secondary metabolite production. While there are a few terms that seem plant- or neuron-related, the dominant signal is bacterial cell envelope construction and modification. ","confidence":"Medium","size":13,"edges":20,"triangles":12,"max_degree":6,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0033485","count":6},{"id":"GO:0052697","count":6},{"id":"GO:0030259","count":6},{"id":"GO:0070395","count":6}]},{"hash":"2145043489975788323","title":"Axon guidance and cerebellar development","description":"Most of the top GO terms cluster around neural development and axon dynamics (axon extension, axon regeneration, axonogenesis, cerebellar cortex formation, and Wnt signaling in neural patterning). Dopamine response supports neuronal signaling context, while mitotic cell cycle may reflect progenitor proliferation; an immune-related term appears but does not dominate. Overall, the functions point to neural development focusing on axon guidance and cerebellar formation. ","confidence":"Medium","size":13,"edges":7,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":11},{"id":"GO:0031532","count":10},{"id":"GO:0045773","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0048679","count":9}]},{"hash":"1412332375828458499","title":"Golgi-ER vesicle trafficking and SNARE assembly","description":"The terms cluster around intracellular vesicle transport involving the ER and Golgi, endosome-to-Golgi and intra-Golgi routing, vesicle fusion events, SNARE complex assembly, and related exocytic processes. This points to a cohesive function in vesicle trafficking and membrane fusion, particularly at the Golgi and secretory pathways.","confidence":"High","size":13,"edges":28,"triangles":27,"max_degree":9,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0045022","count":4},{"id":"GO:0032258","count":4},{"id":"GO:0034498","count":4},{"id":"GO:1903078","count":4}]},{"hash":"1045045692729301009","title":"Vertebrate organogenesis and cell proliferation","description":"The terms show a focus on organ development (heart development; retina development) alongside core proliferation processes (mitotic cell cycle; cell division; cell population proliferation). While there are also general transcription and signaling terms, the prominent themes point to vertebrate organogenesis combined with growth/division, suggesting a cohesive developmental/proliferative cluster rather than a single metabolic pathway. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007601","count":4}]},{"hash":"110030985827246182","title":"DNA Replication and Transcription Machinery","description":"The top terms are dominated by DNA replication and DNA-templated transcription (with leading strand elongation also represented), indicating a core nuclear DNA metabolism theme. Some peroxisomal import and glycosylation terms appear, likely reflecting annotation noise or multi-function roles, but the central cluster aligns with DNA synthesis and transcription functions.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006351","count":5},{"id":"GO:1903936","count":4},{"id":"GO:0071276","count":4},{"id":"GO:2001033","count":4}]},{"hash":"1061005579430294314","title":"Spliceosome-Mediated RNA Processing","description":"The top GO terms cluster around splicing and post-transcriptional regulation of RNA: cis and alternative splicing via the spliceosome, positive/negative regulation of splicing, mRNA modification, and stress-related regulation of mRNA stability, plus translation reinitiation and regulatory ncRNA-mediated gene silencing. This suggests a cohesive group of proteins involved in spliceosome-mediated RNA processing and broader post-transcriptional control.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0010610","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0045292","count":4}]},{"hash":"1779358001995656882","title":"Immune Signaling and Mitochondrial Regulation","description":"The cluster centers on immune-related signaling (positive regulation of T cell polarity; positive regulation of Toll-like receptor 3 signaling) and mitochondrial dynamics (stress-induced mitochondrial fusion; positive regulation of mitochondrial DNA replication), with supporting processes on membrane rafts, PKC signaling, and proteostasis (ubiquitin-dependent ERAD, regulation of peptidase activity). This combination points to a group of proteins coordinating immune responses with mitochondrial function and protein homeostasis, despite some GO terms being flagged as obsolete. ","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:1903905","count":5},{"id":"GO:1990046","count":5},{"id":"GO:0001302","count":5},{"id":"GO:0030433","count":5},{"id":"GO:1903044","count":5}]},{"hash":"1400984868448115837","title":"Unknown","description":"The GO terms span immune signaling, neural development, cell cycle regulation, plant hormone signaling, and organ morphogenesis, with no single cohesive function linking the proteins. The mix of both positive and negative regulatory processes suggests diverse roles rather than a common pathway, making a precise, concise label difficult.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045083","count":2},{"id":"GO:0070427","count":2},{"id":"GO:2000171","count":2},{"id":"GO:0071642","count":2},{"id":"GO:1904908","count":2}]},{"hash":"1030050811843925031","title":"Neuronal synaptic signaling and plasticity machinery","description":"This cluster is dominated by GO terms related to synaptic transmission (glutamatergic), long-term potentiation, exocytosis, GTPase-regulated signaling, actin crosslinking, and serotonin uptake, pointing to proteins involved in neurotransmitter release and synaptic strength modulation. Some terms like heart development or adaptive immune response are likely incidental annotations, but the core signal is neuronal synaptic signaling and cytoskeletal regulation.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0060291","count":2}]},{"hash":"1629789443165286601","title":"Transmembrane nutrient and ion transport","description":"The top GO terms cluster around diverse transmembrane transport activities for multiple substrates (vitamins, galactose, sialic acid, fucose), ions (sodium), and nitrogen compounds (nitrate/nitrite), plus related processes like xenobiotic transport and neurotransmitter loading into vesicles. This points to a cohesive theme of membrane transport functions across varied substrates, rather than a single specific pathway. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3}]},{"hash":"1385093999087428038","title":"Cytoskeleton and mitotic spindle dynamics","description":"The cluster centers on GO terms related to microtubule polymerization, nucleation, cytoplasmic microtubule organization, and spindle organization, indicating a shared role in cytoskeletal dynamics and cell division. There are a few outlier terms (blood pressure regulation, complement activation) that don\u2019t fit this theme, and the connectivity is low, suggesting heterogeneity; nonetheless, the strongest common theme is microtubule- and spindle-associated functions, justifying the label.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003050","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0031116","count":1},{"id":"GO:0007020","count":1},{"id":"GO:0031122","count":1}]},{"hash":"973221332674730812","title":"Mitotic progression and Golgi-ER trafficking","description":"The top GO terms cluster around mitosis (mitotic cell cycle, mitotic spindle assembly, cell division) and cellular growth, while others point to intracellular trafficking (retrograde Golgi-to-ER transport, COPII vesicle budding) and vesicle dynamics. This suggests aTheme where cell division processes are linked with secretory pathway activities, possibly coordinating proliferation with cargo transport. ","confidence":"Medium","size":13,"edges":17,"triangles":0,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0051291","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0090307","count":4}]},{"hash":"1713609161562282850","title":"Unknown","description":"The top GO terms cover defense, development, transcription, cell cycle, and stress responses with no clear shared function, and there are no connections to tie the terms into a single cohesive theme. This heterogeneity makes a concise, representative label unreliable.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":8},{"id":"GO:0001403","count":7},{"id":"GO:0006349","count":7},{"id":"GO:0001501","count":7},{"id":"GO:0030900","count":7}]},{"hash":"281899374961706545","title":"Glycan biosynthesis and secretory pathway involvement","description":"This cluster is dominated by glycosylation-related terms (Lewis a epitope biosynthesis, N-glycan fucosylation, fucose catabolism) and ER-to-Golgi vesicle transport, pointing to glycan biosynthesis and the secretory pathway. Immune- and neural-development terms appear as broader contexts in which glycosylation plays a role, suggesting the label should reflect the central glycosylation/secretory theme with immune and neural associations as secondary. ","confidence":"Medium","size":13,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0036071","count":2},{"id":"GO:0002361","count":2}]},{"hash":"1909805148571044247","title":"Actin dynamics and cytoskeletal signaling","description":"The set is dominated by actin-related GO terms: positive regulation of Arp2/3 complex\u2013mediated actin nucleation, barbed-end actin filament capping, and actin filament depolymerization, pointing to cytoskeleton remodeling as the core theme. Additional terms touch on signaling and broader developmental processes, suggesting some multifunctionality in the proteins or shared pathways, but actin dynamics remains the strongest common thread. Therefore, this cluster is best described as actin cytoskeleton remodeling with associated signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:2000601","count":4},{"id":"GO:0001403","count":3},{"id":"GO:0051016","count":3},{"id":"GO:0031954","count":3}]},{"hash":"1309837839810221813","title":"Neural development and synaptic signaling","description":"The terms point to nervous system development (cerebral cortex tangential migration, spinal cord patterning) and synaptic organization and transmission (protein localization to synapse, NMDA receptor clustering, excitatory postsynaptic potential regulation), with a note of neurotransmitter signaling (octopamine). This combination suggests a cluster centered on neural development and synaptic connectivity rather than unrelated processes.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":2},{"id":"GO:0035418","count":2},{"id":"GO:0032418","count":1},{"id":"GO:0021800","count":1},{"id":"GO:2000463","count":1}]},{"hash":"1495493630826096130","title":"DNA replication and genome maintenance","description":"The top GO terms point to replication, fork dynamics, RNA primer processing during mitosis, recombination, and telomere maintenance, suggesting a core role in DNA replication and genome stability. While apoptosis and spindle assembly appear, the dominant theme is genome maintenance and replication-related processes.","confidence":"High","size":13,"edges":56,"triangles":112,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0044806","count":2}]},{"hash":"1427670605539007264","title":"Glycinergic Synaptic Transmission","description":"This cluster is centered on glycinergic neurotransmission: glycine import, secretion, and glycinergic synaptic transmission, with related terms for amino acid transport and modulation of serotonin signaling. The strong presence of glycine-related terms, alongside supporting serotonin and dopamine metabolism terms, suggests a core function in glycinergic synaptic activity, even though the subnetwork is small and loosely connected.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905847","count":6},{"id":"GO:0051610","count":6},{"id":"GO:0061537","count":6},{"id":"GO:0042420","count":6},{"id":"GO:0036233","count":6}]},{"hash":"902662912385255317","title":"Chromatin Organization and Transcription Regulation","description":"This cluster centers on chromatin-related processes: nucleosome assembly, heterochromatin organization, and negative regulation of transcription by RNA polymerase II, with hints of histone modification states (H3K27me3, H3K4me3) and chromatin localization. Together these terms point to a cohesive function in packaging DNA and modulating transcription in the nucleus.","confidence":"High","size":13,"edges":39,"triangles":54,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":7},{"id":"GO:0006334","count":6},{"id":"GO:0000122","count":4},{"id":"GO:0070828","count":4},{"id":"GO:0098532","count":4}]},{"hash":"545596321966175997","title":"Kinase-driven signaling and cytoskeletal regulation","description":"The top GO terms cluster around positive regulation of kinase activity (autophosphorylation, serine/threonine kinases) and GTPase regulation, indicating active kinase signaling. This is complemented by actin filament depolymerization and various growth/differentiation and signaling pathways (TGF-beta response, gastrulation, invasive growth in response to glucose limitation, mitochondrial-nucleus signaling, and ubiquitin-related regulation), suggesting a network where kinase signaling modulates cytoskeletal dynamics and broader growth and developmental responses.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0031954","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0071902","count":4},{"id":"GO:0001403","count":3},{"id":"GO:0007369","count":3}]},{"hash":"1839210116651224010","title":"ER organization and nuclear envelope dynamics","description":"The cluster centers on endoplasmic reticulum organization (ER tubular network, ER inheritance), ER stress response, and ER-dependent processes, plus protein transport into membrane rafts and nuclear pore complex assembly, with mitotic nuclear membrane reassembly also present. This combination points to a cohesive theme of ER architecture, trafficking between ER and membranes, and nuclear envelope dynamics, rather than disparate signaling. A couple of terms (ABA response and sweet/bitter taste perception) appear, but they are likely incidental annotations near the core ER/nuclear envelope theme.","confidence":"High","size":13,"edges":14,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0009737","count":2},{"id":"GO:0071786","count":2},{"id":"GO:0048309","count":2},{"id":"GO:0032596","count":2},{"id":"GO:0050916","count":2}]},{"hash":"1288605145413596894","title":"RNA Processing and Signaling Regulators","description":"Proteins in this cluster link RNA processing steps (mRNA capping, rRNA modification) with diverse signaling and stress-response pathways (TGF-beta, Fas, Hippo), and include development/immune-related roles. This points to a module of regulators that connect RNA biogenesis to signaling and cell fate pathways, rather than a single, unified function. Confidence: Medium","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":2},{"id":"GO:0008630","count":2},{"id":"GO:0000154","count":2},{"id":"GO:1902044","count":2},{"id":"GO:0006370","count":2}]},{"hash":"2271046145990764504","title":"Unknown","description":"The top GO terms are a mix of disparate processes (amino acid and polyamine biosynthesis/catabolism, various N-terminal acetylation events, and unrelated eukaryotic processes like angiogenesis and centromeric cohesion), with several obsolete terms. There isn\u2019t a coherent, single biological theme tying these functions together, so a precise, representative label cannot be assigned.","confidence":"","size":13,"edges":72,"triangles":227,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":12},{"id":"GO:0045150","count":12},{"id":"GO:0019491","count":12},{"id":"GO:0032920","count":12},{"id":"GO:0071962","count":12}]},{"hash":"1988093954027703196","title":"Neural signaling and inflammatory regulation","description":"The top GO terms center on neural processes (visual perception, visual learning, dopaminergic synaptic transmission) and signaling cascades (ERK1/ERK2), alongside inflammatory pathways (inflammatory response, macrophage chemotaxis regulation, prostaglandin response). The mix suggests a cluster focused on neural signaling with immune/inflammatory modulation, rather than a single tissue-specific function; some terms like heart development may reflect shared signaling pathways or pleiotropy rather than a core cluster theme.","confidence":"Medium","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007601","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0001963","count":3}]},{"hash":"625443676369703459","title":"Microtubule-based cytoskeleton and mitosis","description":"This cluster is enriched for microtubule- and cytoskeleton-related processes: motile cilium assembly, cytoplasmic microtubule organization, mitotic spindle midzone assembly, and positive regulation of cytokinesis, pointing to a shared role in microtubule dynamics during mitosis and ciliogenesis. A few other terms (interferon response, aggrephagy, ERAD) are peripheral and do not define the core function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044458","count":2},{"id":"GO:0032886","count":1},{"id":"GO:0032467","count":1},{"id":"GO:0051256","count":1},{"id":"GO:0031122","count":1}]},{"hash":"1327327958143100984","title":"Glutamatergic synaptic regulation and pain perception","description":"This cluster is enriched for terms related to regulation of sensory perception of pain and regulation/negative regulation of glutamatergic synaptic transmission, along with prepulse inhibition and behavioral responses (amphetamine, morphine) and visual learning, indicating a cohesive theme around glutamatergic signaling and pain modulation. A minor outlier term about cell wall macromolecule catabolic process is present but does not disrupt the overall neural-signaling focus.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051930","count":2},{"id":"GO:0051967","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0001975","count":2}]},{"hash":"1077084018392186566","title":"Neural sensory signaling and ion homeostasis","description":"The top GO terms cluster around neural sensing and behavior (neuron migration, mechanosensory behavior, sour taste perception, pain-related mechanosensation, salt aversion) and ion balance (sodium ion homeostasis), pointing to a coherent theme of neural sensory processing with ionic regulation; a few metabolic terms are peripheral. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001764","count":2},{"id":"GO:0017183","count":1},{"id":"GO:0050843","count":1},{"id":"GO:0050915","count":1},{"id":"GO:0035199","count":1}]},{"hash":"2091047471472414273","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007014","count":3},{"id":"GO:1902187","count":3},{"id":"GO:0061158","count":3},{"id":"GO:2000637","count":3},{"id":"GO:0042787","count":3}]},{"hash":"312207190549784086","title":"Neuronal development and axon guidance","description":"Primarily neural development: neuron migration, axon guidance, and synapse maturation, with centrosome\u2011associated cytoskeletal organization supporting these processes. A few terms (bone ossification, thyroid hormone generation) appear less directly connected, likely annotation breadth.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001957","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0034454","count":2},{"id":"GO:0097491","count":1},{"id":"GO:0021612","count":1}]},{"hash":"869761960996073437","title":"Neural Development Signaling Regulation","description":"This cluster centers on terms tied to cerebellum structure, astrocyte differentiation regulation, neuronal transport, and multiple signaling pathways (Wnt/PCP, SMAD, ephrin) as well as JUN phosphorylation. Taken together, these terms point to neural development and modulation of neuronal signaling, with a few peripheral terms (LDL clearance, muscle fate) that may reflect broader annotations. Confidence: Medium","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034383","count":2},{"id":"GO:0021589","count":1},{"id":"GO:0048712","count":1},{"id":"GO:0042694","count":1},{"id":"GO:1903077","count":1}]},{"hash":"654564823242615393","title":"Mitotic Control and ER Stress/Autophagy","description":"The top GO terms cluster around cell cycle progression (G1/S transition, cell division), the ER unfolded protein response, and initiation of autophagy via ULK1 complex assembly, suggesting a theme of coordinating cell division with cellular stress responses. Some other terms touch broader transcription regulation and antiviral responses, but the core signals point to mitotic control coupled with stress pathways.","confidence":"Medium","size":12,"edges":19,"triangles":7,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032026","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0030968","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0044828","count":3}]},{"hash":"1075041684897317403","title":"Eye and Heart Development Signaling","description":"This cluster centers on vertebrate organ development (retina/eye and heart) and signaling pathway regulation (ERK cascade, GTPase activity) with proliferation and dopaminergic synaptic transmission, implying a cohesive theme of developmental signaling in neural/visual systems and cardiac tissue.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0008284","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0070374","count":7}]},{"hash":"1120639389752136884","title":"Ubiquitin-Proteasome Proteostasis in Neurons","description":"The cluster centers on ubiquitin-mediated protein turnover (SCF-dependent ubiquitination and proteasomal degradation) with supporting neural-context terms (synapse assembly, neuron apoptosis signaling, circadian regulation) and some cell-cycle stress signals, suggesting a proteostasis/stress response theme in neural systems.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0000209","count":5},{"id":"GO:0046785","count":4},{"id":"GO:0000083","count":4}]},{"hash":"596448502245437275","title":"Cardiac Muscle Morphogenesis and Neural Signaling","description":"The cluster contains strong signals for cardiac development and function (ventricular heart morphogenesis, regulation of heart contraction) alongside neural-related terms (short-term memory, long-term synaptic potentiation, Schwann cell development), suggesting a broader theme of development and function across heart, muscle, and nervous system tissues, with vascular development also represented.","confidence":"Medium","size":12,"edges":8,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055010","count":10},{"id":"GO:0031954","count":10},{"id":"GO:0097274","count":10},{"id":"GO:0007614","count":10},{"id":"GO:2001015","count":10}]},{"hash":"1257371823407657998","title":"Embryonic development and pattern formation","description":"These terms point primarily to embryonic morphogenesis and axis patterning (face development, proximal/distal pattern formation, embryonic digestive tract development), which provides a cohesive developmental theme for the cluster. The metabolic terms (proline, glycine betaine, retinal metabolism, carbon utilization, etc.) appear ancillary and may reflect context-dependent metabolic activity in developing cells.","confidence":"Medium","size":12,"edges":33,"triangles":58,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060324","count":8},{"id":"GO:0055129","count":8},{"id":"GO:0015976","count":8},{"id":"GO:0019285","count":8},{"id":"GO:0009450","count":8}]},{"hash":"456630146337842739","title":"Translation initiation and RNA processing","description":"The top GO terms are dominated by translation initiation and preinitiation complex formation (translation reinitiation, initiation complex formation, initiation regulation), including viral IRES-dependent initiation, pointing to translation machinery. Additional terms cover RNA processing/regulation (spliceosome-associated splicing regulation, regulatory ncRNA-mediated gene silencing) and rRNA maturation, suggesting involvement in RNA maturation alongside translation control. Overall, the cluster appears centered on translation initiation with linked RNA processing activities.","confidence":"High","size":12,"edges":26,"triangles":23,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0006446","count":7},{"id":"GO:0075525","count":7},{"id":"GO:0075522","count":7}]},{"hash":"887800114295290206","title":"Neuroimmune Regulation and Pain Modulation","description":"These terms point to neuromodulation via neurotransmitter metabolism and signaling (acetylcholine, dopamine, glutamate) alongside immune/inflammatory regulation (IL-8 and IL-1\u03b2 production, chemokine regulation), plus autonomic outputs (blood pressure) and histamine-driven gastric secretion. The common thread is neuromodulatory and immune signaling that modulates pain perception, suggesting a cohesive neuroimmune pain-modulation cluster.","confidence":"High","size":12,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051930","count":11},{"id":"GO:0090198","count":11},{"id":"GO:0060408","count":11},{"id":"GO:2000484","count":11},{"id":"GO:0032651","count":11}]},{"hash":"1896717070149376452","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":9},{"id":"GO:1901253","count":9},{"id":"GO:0051865","count":9},{"id":"GO:1903762","count":9},{"id":"GO:0046597","count":8}]},{"hash":"1869918984861891498","title":"Mitochondrial respiration and mitophagy","description":"The cluster is centered on mitochondrial energy production (electron transport, respiratory chain II assembly, regulation of cellular respiration) and mitochondrial quality control (mitophagy), with associated oxidative stress responses (SOD activity and detoxification), indicating a cohesive mitochondria-focused function.","confidence":"High","size":12,"edges":57,"triangles":159,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":4},{"id":"GO:0010259","count":3},{"id":"GO:0032435","count":2},{"id":"GO:0034553","count":2},{"id":"GO:0000422","count":2}]},{"hash":"2180845343972560413","title":"Neuronal GPCR Signaling and Cytokine Regulation","description":"The top GO terms cluster around GPCR-mediated signaling that activates adenylate cyclase, regulation of neurotransmitter pathways (acetylcholine and dopamine), and pain modulation, alongside immune regulation terms (IL-8 and IL-1\u03b2 production) and cardiovascular/retinal context (blood pressure regulation and photoreceptor maintenance). This points to a theme of GPCR-driven signaling coordinating neural, vascular, and immune responses, with some metabolic/retinal terms as ancillary associations.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0051930","count":11},{"id":"GO:0090198","count":11}]},{"hash":"1626073762807630059","title":"Gram-positive cell wall biosynthesis and antibiotic production","description":"This cluster is driven by GO terms such as lipoteichoic acid biosynthesis, cell wall organization, and antibiotic biosynthetic/metabolic processes, suggesting a cohesive theme around Gram-positive bacterial cell wall assembly and antibiotic production. Some flavonoid-related and xenobiotic terms appear, likely due to cross-species annotations or noise, but the dominant signal supports the cell wall/antibiotic function.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0033485","count":10},{"id":"GO:0052697","count":10},{"id":"GO:0030259","count":10},{"id":"GO:0070395","count":10},{"id":"GO:0016999","count":10}]},{"hash":"569658325424411529","title":"Embryonic Development and Morphogenesis","description":"The top GO terms point strongly to embryogenesis, organ formation, and differentiation (e.g., left-right patterning, placental development, trophoblast differentiation, and EMT in heart development), with additional general splicing activity and a plant-related nodulation term contributing less to the overall theme. This suggests a coherent cluster centered on developmental programs and tissue morphogenesis.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0009877","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003323","count":2}]},{"hash":"1972091022262034482","title":"Nuclear RNA processing and gene regulation","description":"The cluster\u2019s terms center on RNA processing and regulation within the nucleus: positive regulation of mRNA splicing via the spliceosome, RNA exon ligation, and regulatory ncRNA-mediated gene silencing, complemented by DNA replication and protein import\u2014suggesting a cohesive theme of nuclear RNA metabolism and transcriptional/post-transcriptional control. Some terms are obsolete or developmental in nature, likely reflecting annotation noise rather than core function. ","confidence":"Medium","size":12,"edges":40,"triangles":72,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0017038","count":2},{"id":"GO:0060303","count":2}]},{"hash":"689226601885422046","title":"Epithelial Polarity and Cell Migration","description":"The top GO terms center on establishing epithelial cell polarity, actin filament bundle assembly, and cell migration, which together point to roles in polarized cell organization and cytoskeleton-driven movement. Protein ubiquitination appears as a common regulatory layer, potentially modulating these processes. Some terms involve adipogenesis and immune signaling (IL-12 regulation, NOD pathway, macrophage chemokine production), which may reflect context-specific or broader regulatory connections, but the core theme is clearly cell polarity and motility.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":5},{"id":"GO:0051017","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0045444","count":5}]},{"hash":"758161619400013534","title":"Neuronal ion transport and synaptic plasticity","description":"These proteins show enrichment for membrane ion transport (sodium, potassium, calcium), which underlies neuronal excitability, plus terms for synaptic plasticity (long-term potentiation/depression) and receptor internalization, suggesting a neural signaling/plasticity theme. The cerebellar granule cell differentiation and conditioned taste aversion terms reinforce a neural/learning context, making this cluster best described as neuronal ion transport linked to synaptic plasticity. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:1900273","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0016567","count":3}]},{"hash":"2227855853664472068","title":"Neural and sensory development with immune signals","description":"The cluster centers on neural and sensory development, as shown by prepulse inhibition, axon guidance, and synapse assembly, plus inner ear stereocilium organization. Additional terms point to broader developmental processes (myoblast development, ureteric bud development, stem cell differentiation) and some immune signaling (neutrophil chemotaxis, macrophage cytokine production), indicating a developmental program with a neural/sensory emphasis and peripheral cross-talk.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":"wound healing","top_go_terms":[{"id":"GO:0060134","count":4},{"id":"GO:0090023","count":4},{"id":"GO:0060907","count":3},{"id":"GO:0019800","count":3},{"id":"GO:0060122","count":3}]},{"hash":"675620878044261768","title":"Neural differentiation and organ morphogenesis","description":"The top GO terms include multiple neural development processes (ventral spinal cord interneuron specification, spinal cord motor neuron fate specification, GABAergic interneuron differentiation, hypothalamus development) alongside diverse organ morphogenesis terms (endocrine pancreas development, female gonad development, bronchiole development, ureteric bud morphogenesis). This suggests the cluster centers on neural differentiation with broader organ development signals, hence the combined label.","confidence":"Medium","size":12,"edges":29,"triangles":39,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021521","count":4},{"id":"GO:0021520","count":4},{"id":"GO:0031018","count":4},{"id":"GO:0008585","count":4},{"id":"GO:0021527","count":3}]},{"hash":"1224416127715400801","title":"Ubiquitin-Mediated Immune Regulation and Apoptosis","description":"The top GO terms cluster around ubiquitin-related processes (ubiquitin-dependent ERAD, deubiquitination) and negative regulation of key immune signaling pathways (NF-kappaB, TLR3) as well as extrinsic apoptotic signaling, suggesting a module of proteins that dampen immune responses and modulate cell death via ubiquitin pathways. A couple of terms (e.g., sister chromatid biorientation) appear less related and may be incidental; overall the theme is cohesive around ubiquitin-mediated immune regulation.","confidence":"Medium","size":12,"edges":34,"triangles":28,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0034140","count":4},{"id":"GO:0016579","count":3},{"id":"GO:0043124","count":3},{"id":"GO:1902042","count":3}]},{"hash":"2164160041016736997","title":"Cell Polarity and Surface Signaling","description":"This cluster centers on epithelial cell polarity and multiple surface signaling pathways, including small GTPase\u2013mediated signaling, Wnt and EGFR signaling, and T cell receptor signaling, plus endocytosis and phagocytic processes. The frequent GO terms point to coordinated control of cell shape, polarity establishment, cytoskeletal dynamics (e.g., podosome assembly), and membrane trafficking, suggesting these proteins work together to regulate how cells polarize and respond to external cues at the plasma membrane.","confidence":"High","size":12,"edges":12,"triangles":6,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":3},{"id":"GO:0071803","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0043652","count":3},{"id":"GO:0051835","count":3}]},{"hash":"58070873462275091","title":"Transmembrane Solute Transporters","description":"The GO terms show transport across membranes for vitamins, sugars, sialic acid, xenobiotics, nitrates/nitrites, sodium, and even neurotransmitter loading into vesicles, indicating a cluster of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":12,"edges":28,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3}]},{"hash":"751095333617475391","title":"Nuclear import, transcription, and spindle organization","description":"This cluster is dominated by nuclear-related terms: DNA-templated transcription, NLS-bearing protein import into nucleus, and spindle organization/G1/S cell cycle transitions, with SMAD signaling also tied to nuclear events. A Golgi localization term is present but likely less representative. Overall, the proteins appear linked to nuclear transport and cell-cycle\u2013related transcription and spindle regulation.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0000042","count":1},{"id":"GO:0007184","count":1},{"id":"GO:0000061","count":1},{"id":"GO:0036228","count":1}]},{"hash":"1847990229574858826","title":"Neural development and axon guidance signaling","description":"The top GO terms are dominated by nervous system development, axon guidance, and signaling pathways (Roundabout, Smoothened, ERK cascade), indicating a cohesive theme of neural development and neuronal guidance. Immune and skeletal development terms appear but are less central to the core function of this cluster. ","confidence":"High","size":12,"edges":47,"triangles":81,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":12},{"id":"GO:0001822","count":12},{"id":"GO:0050852","count":12},{"id":"GO:0007224","count":12},{"id":"GO:0007399","count":12}]},{"hash":"155011686636562287","title":"Unknown","description":"This cluster shows a scattered mix of GO terms across neural development, signaling pathways, and plant development with no shared function linking the proteins (Edges: 0). Because there is no coherent functional theme, a single representative label cannot be confidently assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001199","count":1},{"id":"GO:0038095","count":1},{"id":"GO:0030239","count":1},{"id":"GO:0048366","count":1},{"id":"GO:0048013","count":1}]},{"hash":"2279167498623751264","title":"Autophagy and ubiquitin-mediated turnover","description":"The cluster is dominated by terms related to autophagy (autophagosome targeting and engulfment, ribophagy) and ubiquitin-mediated protein catabolism (ubiquitination types and ubiquitin-dependent degradation), suggesting a cohesive theme around autophagic turnover regulated by ubiquitin signals. A term like prostate gland growth appears peripheral, but the core signals converge on autophagy-ubiquitin pathways.","confidence":"High","size":12,"edges":15,"triangles":4,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0061753","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0060736","count":2},{"id":"GO:2000058","count":2},{"id":"GO:0006513","count":2}]},{"hash":"1513320085758477709","title":"BMP sequestration in ECM and skeletal development","description":"The core terms point to extracellular matrix remodeling and skeletal biology: collagen fibril organization, BMP sequestration in the ECM and BMP binding, and the negative regulation of osteoblast proliferation and chondrocyte differentiation. These indicate a function cluster tied to bone and cartilage formation and ECM interactions. A few GO terms (DNA integration, translation, antibiotic response) appear as unrelated noise and do not define the primary function.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0006313","count":1}]},{"hash":"791747638638475170","title":"Dendritic Spine Morphogenesis and Actin Remodeling","description":"The cluster shows strong enrichment for synapse assembly, dendritic spine development, and Rac-mediated actin cytoskeleton regulation, pointing to neuronal synaptogenesis and dynamic cytoskeletal remodeling in dendritic spines.","confidence":"High","size":12,"edges":15,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":4},{"id":"GO:0010592","count":3},{"id":"GO:0097178","count":3},{"id":"GO:0060999","count":3},{"id":"GO:0061001","count":3}]},{"hash":"1270579030908063033","title":"Tissue Development and Differentiation","description":"The proteins are linked to a broad set of developmental and differentiation processes across multiple tissues\u2014muscle (myotube differentiation), heart (right ventricle formation, neural crest\u2013related heart development), neural (GABAergic neuron differentiation, myelination), bone (osteoclast differentiation), and kidney fibroblast development\u2014with transcription by RNA polymerase II indicating active regulation of these programs. This pattern supports a unifying theme of developmental differentiation across tissues rather than a single pathway or function.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0014737","count":11},{"id":"GO:0003219","count":11},{"id":"GO:0021858","count":11},{"id":"GO:0043433","count":11}]},{"hash":"1382738149378840143","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":15,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0046785","count":2},{"id":"GO:0001578","count":2},{"id":"GO:0030435","count":2},{"id":"GO:1902777","count":2},{"id":"GO:0009097","count":2}]},{"hash":"872802103835183764","title":"Developmental Regulation and Gene Expression","description":"This cluster centers on processes involved in development and regulation of gene expression. The top terms include developmental categories\u2014skeletal system development, neuron projection development, lens fiber cell differentiation, and multicellular organism development\u2014suggesting a developmental theme. In addition, there are regulatory processes tied to gene expression and signaling, such as positive regulation of NF-kappaB transcription factor activity, histone H2A K63-linked ubiquitination, mRNA splicing via spliceosome, and regulation of Rho signaling. Although some terms are obsolete, the combination points to coordination between development and transcriptional/post-transcriptional control. Therefore the label Developmental Regulation and Gene Expression is representative.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070535","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0031175","count":3}]},{"hash":"548413222117396762","title":"Embryonic development and cytoskeletal remodeling","description":"The top terms point to developmental processes (gastrulation, TGF-beta\u2013related signaling) and cytoskeletal dynamics (barbed-end actin capping, actin depolymerization), with notes of mitochondrial-nucleus signaling and growth responses that can accompany embryogenesis. Together they suggest a cluster focused on development with coordinated cytoskeletal regulation and signaling cross-talk. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043473","count":3},{"id":"GO:0001403","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0031954","count":2},{"id":"GO:0007369","count":2}]},{"hash":"2038350603426781426","title":"Coagulation and fibrinolysis regulation","description":"The top terms cluster around blood coagulation (activation and regulation), plasminogen activation and fibrinolysis, and regulation of fibrinogen, with supporting signals from lipopolysaccharide response and lectin pathway complement activation. This points to a cohesive module of coagulation cascade activity intertwined with fibrinolysis and inflammatory signaling, justifying a label centered on coagulation and fibrinolysis regulation.","confidence":"High","size":12,"edges":13,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030194","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0002542","count":2},{"id":"GO:0014909","count":2},{"id":"GO:0007596","count":2}]},{"hash":"1113185253243053360","title":"Oxidative stress response and detoxification","description":"The top GO terms cluster around redox biology and detox pathways: response to hydrogen peroxide, cellular oxidant detoxification, cell redox homeostasis, and response to xenobiotic stimulus. While a few terms relate to tissue-specific processes (endothelial or mammary gland proliferation), the dominant signal is oxidative stress management and detoxification, suggesting a shared functional theme for the cluster.","confidence":"High","size":12,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0010269","count":2},{"id":"GO:0030416","count":1},{"id":"GO:0001885","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0042345","count":1}]},{"hash":"1424845370926303230","title":"Diverse Transmembrane Transport","description":"Based on the Top GO terms, this cluster centers on transmembrane transport of a variety of substrates (potassium, nitrates/nitrites, sugars, vitamins, sialic acid, and xenobiotics) and a related role in neurotransmitter loading, suggesting these proteins largely function as membrane transporters with diverse substrates rather than a single metabolic or signaling pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":6},{"id":"GO:0042128","count":6},{"id":"GO:0035461","count":4},{"id":"GO:0015757","count":4},{"id":"GO:0015739","count":4}]},{"hash":"408832953300978106","title":"Neurodevelopment and axon guidance","description":"Dominant GO terms center on neural development, neuron projection formation, and neural tube closure, with supporting axon guidance and facial nerve organization terms; a few outliers exist, but the core signal points to neurodevelopmental processes.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0007405","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0060907","count":1}]},{"hash":"1006616544530083724","title":"Antiviral innate signaling and translation regulation","description":"The GO terms point to innate immune responses and interferon-related signaling (GO:0045087, GO:0060335) as central themes, with a parallel set of terms describing regulation and components of translational initiation (e.g., cap-dependent initiation, preinitiation complex, IRES-dependent translation). This combination suggests proteins that participate in antiviral innate signaling while also modulating host translation initiation, a common axis in controlling viral infection.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060335","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0043547","count":2},{"id":"GO:1902416","count":1}]},{"hash":"1082708660753924268","title":"Regulated signaling via cAMP/cGMP and related processes","description":"These terms cluster around regulation and signaling, especially phosphorylation and cyclic-nucleotide\u2013mediated pathways (cGMP, adenylate cyclase), with cardiac-related regulation and Ras signaling; a few items (meiotic control, immune and drug responses) are peripheral, but overall the cluster reflects general signaling modulation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0046580","count":2},{"id":"GO:0002027","count":2},{"id":"GO:0045013","count":2},{"id":"GO:0046007","count":2}]},{"hash":"1275196823372295817","title":"Neuroimmune Signaling and Development","description":"The top GO terms combine innate immune responses (innate immune response, NF-kappaB regulation, LPS signaling, interferon-beta production) with neural development processes (axonogenesis, corpus callosum development, synapse assembly) and pain-related behavior, suggesting a cluster of proteins involved in neuroimmune interactions affecting brain development and signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0051092","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0051965","count":3}]},{"hash":"2302362811322914924","title":"Muscle, heart, and nerve development","description":"The cluster is enriched for developmental processes spanning muscle formation (myoblast fusion, response to muscle activity), heart/vascular development (angiogenesis, heart development), and nerve-related differentiation (Schwann cell development, excitatory postsynaptic potential). The presence of mitotic cell cycle terms fits general developmental proliferation. Overall, the proteins seem linked to tissue formation and maturation across muscle, heart, and nervous systems.","confidence":"Medium","size":11,"edges":45,"triangles":96,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0014044","count":5},{"id":"GO:0000086","count":5},{"id":"GO:0009738","count":5}]},{"hash":"569657433857636930","title":"Cardiac development and vascular morphogenesis","description":"The top GO terms cluster around heart and muscle development and function (ventricular cardiac muscle tissue morphogenesis; regulation of heart contraction) and vessel formation (branching involved in blood vessel morphogenesis), suggesting a cardiovascular/muscle-development theme. Some outliers (e.g., Schwann cell development, memory) are less aligned, but the dominant signal supports a cardiovascular/muscle focus. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043388","count":11},{"id":"GO:0055010","count":10},{"id":"GO:0031954","count":10},{"id":"GO:0097274","count":10},{"id":"GO:0007614","count":10}]},{"hash":"1676186812591406688","title":"Developmental Gene Regulation","description":"The top GO terms cluster around development (pituitary gland development, multicellular organism development, atrioventricular node cell fate commitment, metanephros development) and transcriptional control (negative regulation of transcription by RNA polymerase II), suggesting the proteins participate in coordinating developmental programs via gene expression. Some terms reflect other processes (immune response, metabolism, tRNA modification), which may indicate pleiotropy or annotation noise, but the dominant theme is development and regulation of transcription.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0032496","count":4}]},{"hash":"1668987405285208199","title":"Diverse Metabolite Biosynthesis","description":"Top GO terms point to multiple, distinct biosynthetic pathways (antibiotic, biotin, lysine, ectoine, porphyrin/heme), plus related oxidation-reduction and amine-related processes. The absence of a single cohesive function and the presence of several biosynthetic processes indicate this cluster spans diverse metabolite production rather than one specific pathway. Therefore, a broad label like Diverse Metabolite Biosynthesis captures its overall theme.","confidence":"Medium","size":11,"edges":44,"triangles":87,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0019878","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0006782","count":3},{"id":"GO:0009102","count":3}]},{"hash":"577003430833557599","title":"Neural development and sensory signaling","description":"The cluster shows strong enrichment for neural and sensory-related GO terms, including sensory perception of pain, visual perception/visual learning, and dopaminergic synaptic transmission, along with regulation of ERK signaling and developmental processes. This suggests proteins involved in neural development and sensory signal processing rather than a non-specific mix of functions.","confidence":"High","size":11,"edges":33,"triangles":45,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0006351","count":6},{"id":"GO:0010759","count":5},{"id":"GO:0001963","count":5}]},{"hash":"119988795589075818","title":"Unknown","description":"These proteins are annotated with a mix of biosynthetic processes (lipid, galactose, triglyceride, antibiotic biosynthesis) along with immune signaling and transcription regulation terms, and there is no single cohesive function connecting all terms or any network connectivity to tie them together. None","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008611","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0006012","count":2},{"id":"GO:0009089","count":2}]},{"hash":"1921101200223897016","title":"Prostaglandin signaling and vascular-platelet regulation","description":"The cluster\u2019s top terms center on prostaglandin biosynthesis and the cyclooxygenase pathway, which are key to inflammatory signaling and platelet activation. Supporting terms like platelet aggregation and regulation of smooth muscle cell chemotaxis reinforce a vascular/platelet function theme. Estradiol response also links to hormonal modulation of vascular processes, while oxidant detoxification and DNA repair appear less central. This combination suggests a cohesive theme around lipid signaling influencing vascular and platelet regulation.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0006289","count":3},{"id":"GO:0060316","count":3},{"id":"GO:0001516","count":3},{"id":"GO:0045669","count":3}]},{"hash":"462574770150607864","title":"Unknown","description":"The terms span antibiotic biosynthesis, tRNA modification (wybutosine), protein methylation, transcription regulation, mitotic spindle checkpoint control, and various catabolic/metabolic processes, with no clear shared pathway or function tying them together; therefore there is no coherent label for the cluster.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006481","count":1},{"id":"GO:1901106","count":1},{"id":"GO:0017000","count":1},{"id":"GO:0010906","count":1},{"id":"GO:0090266","count":1}]},{"hash":"1662173072307603036","title":"Multitissue development and differentiation","description":"The proteins link to development/differentiation across tissues: muscle differentiation (myotube formation, negative regulation of myoblast proliferation, muscle atrophy regulation), cardiac development (right ventricle formation, neural crest\u2013driven outflow tract morphogenesis), nervous system differentiation (GABAergic neuron differentiation, myelination), and other lineage differentiation (osteoclast differentiation, renal interstitial fibroblast development).","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0014737","count":7},{"id":"GO:0003219","count":7},{"id":"GO:0021858","count":7},{"id":"GO:0043433","count":7},{"id":"GO:0045670","count":7}]},{"hash":"1959647871540079744","title":"Bacterial cell envelope biosynthesis and metabolism","description":"The top GO terms cluster around cell envelope construction (phosphatidylcholine biosynthesis, peptidoglycan biosynthetic process, cell wall organization) and cell shape regulation, pointing to proteins involved in bacterial membrane and cell-wall biogenesis. Supporting terms related to metabolism (formate catabolic process, response to hypoxia) suggest membrane-associated metabolic adaptation. There are a few outliers (selenium compound metabolism, inflammatory response, obsolete terms) that may reflect annotation noise, but the core theme is about cell envelope biosynthesis and related metabolism.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006656","count":3},{"id":"GO:0001887","count":3},{"id":"GO:0071555","count":2},{"id":"GO:0008360","count":2},{"id":"GO:0009252","count":2}]},{"hash":"748171725870625056","title":"Nuclear transcription and RNA processing proteins","description":"Top GO terms indicate nuclear functions centered on transcription regulation and RNA processing, including DNA-templated transcription, its regulation, and RNA processing/modification (rRNA/tRNA) with ribosomal subunit export. While a couple of developmental terms appear (roof of mouth development, nodulation), the dominant signal is transcription and ribonucleoprotein biogenesis in the nucleus, supporting this label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0090398","count":2},{"id":"GO:0006364","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0006355","count":2}]},{"hash":"62332754200786308","title":"Spliceosome-mediated RNA processing","description":"The cluster centers on mRNA splicing and spliceosome assembly (mRNA cis splicing via spliceosome, spliceosomal complex assembly, snRNP assembly) and related RNA metabolism (P-body assembly). Secondary associations include ribosome biogenesis and chromatin-related processes, but the dominant theme is RNA splicing and processing.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":11},{"id":"GO:0000245","count":9},{"id":"GO:0009737","count":8},{"id":"GO:0033962","count":8},{"id":"GO:0042633","count":8}]},{"hash":"1550526485885668184","title":"RNA splicing regulation and mRNA processing","description":"The cluster is dominated by GO terms about spliceosome-mediated splicing (cis and alternative), and regulation of splicing, along with mRNA processing, stability, and modification, all pointing to post-transcriptional control of gene expression centered on RNA splicing and processing.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0002188","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0048025","count":9},{"id":"GO:1901407","count":9}]},{"hash":"482289481215528466","title":"Diverse transmembrane transporters for nutrients and ions","description":"The top GO terms are dominated by transmembrane transport of a wide range of substrates (nitrate/nitrite, galactose, sialic acid, fucose, vitamins, sodium ions, xenobiotics) and a vesicular transport step (neurotransmitter loading). This suggests the proteins function primarily as membrane transporters handling diverse substrates, with a related vesicular transport component.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":10},{"id":"GO:0035461","count":7},{"id":"GO:0015757","count":7},{"id":"GO:0015739","count":7},{"id":"GO:0006855","count":7}]},{"hash":"2296438262350914411","title":"Gene Expression Regulation and Metabolic Signaling","description":"The top GO terms indicate a strong emphasis on regulating gene expression, including DNA-templated transcription, mRNA splicing, and regulatory ncRNA-mediated silencing. In addition, several terms point to modulation of signaling pathways linked to metabolism, such as insulin receptor signaling, insulin receptor internalization, PI3K/AKT signaling, and glucose import. Taken together, the proteins appear to coordinate transcriptional/post-transcriptional control with metabolic signaling and nutrient sensing.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0042733","count":1}]},{"hash":"746579166197854133","title":"Ectodermal organogenesis and BMP signaling","description":"This cluster is dominated by GO terms tied to development of ectodermal tissues and organ systems, notably hair follicle development, cranial skeleton morphogenesis, lens fiber differentiation, and positive regulation of BMP signaling. These point to a common theme of tissue morphogenesis and signaling pathways guiding ectodermal organ development. There are a few outlier terms (immune regulation, viral process, deubiquitination) that may reflect broader regulatory roles of the proteins or annotation noise, but the core set supports a developmental theme centered on BMP-mediated ectodermal organogenesis.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051797","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0045590","count":2},{"id":"GO:0030513","count":2}]},{"hash":"1724418262605160241","title":"Secretory pathway and protein processing in development","description":"The cluster's prominent GO terms center on the secretory pathway (protein localization to Golgi, protein secretion, processing) and ER-stress\u2013related apoptosis, with developmental annotations (embryo development, axis specification). This points to a cohesive theme of protein maturation and trafficking during development.","confidence":"Medium","size":11,"edges":14,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0002361","count":2},{"id":"GO:0050709","count":2},{"id":"GO:0040014","count":2},{"id":"GO:0000042","count":2},{"id":"GO:0009306","count":2}]},{"hash":"16029213419477146","title":"Embryonic organ morphogenesis and placental development","description":"The top GO terms are strongly biased toward embryonic development and tissue formation (cartilage morphogenesis, placental/embryo differentiation, left-right patterning, heart-associated EMT), suggesting a cluster of proteins involved in embryogenesis and organogenesis across multiple tissues. A couple of general cellular processes appear as incidental terms but do not define the cluster\u2019s main function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":8},{"id":"GO:0060707","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0060806","count":8}]},{"hash":"2230018636899336468","title":"Cell Growth and Division Under Stress","description":"These terms cluster around fundamental cellular processes that support growth and proliferation (ribosome biogenesis, DNA-templated transcription, mitotic cell cycle, and cell division) while also including a stress-response component (ER stress\u2013induced apoptotic signaling). The mix suggests a broad growth/maintenance program rather than a highly specific pathway, so a label focused on growth and division under stress seems representative, though the developmental GO terms introduce some ambiguity.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001403","count":8},{"id":"GO:0042254","count":8},{"id":"GO:0006349","count":8},{"id":"GO:0001501","count":8},{"id":"GO:0061099","count":8}]},{"hash":"1194964132031804264","title":"Membrane Transporters for Metabolites and Ions","description":"The cluster is dominated by diverse transmembrane transport terms (nitrate/nitrite, galactose, sialic acid, fucose, vitamins, xenobiotics, sodium ions) and a vesicle-related term (neurotransmitter loading into synaptic vesicle), pointing to a family of membrane transport proteins handling various substrates and possibly vesicular transport. ","confidence":"High","size":11,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":10},{"id":"GO:0035461","count":8},{"id":"GO:0015757","count":8},{"id":"GO:0015739","count":8},{"id":"GO:0006855","count":8}]},{"hash":"2008116128140284638","title":"Developmental patterning and organ morphogenesis","description":"The GO terms cluster around embryonic development, pattern formation, organ morphogenesis (including metanephros), tissue identity, and cytoskeletal/adhesion processes (intermediate filament assembly and calcium-dependent cell\u2013cell adhesion). Together these suggest a theme of developmental patterning and structural organization during organ formation, with some notes on cardiac development terms as part of broader developmental roles.","confidence":"Medium","size":11,"edges":47,"triangles":107,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":4},{"id":"GO:0051291","count":3},{"id":"GO:0048496","count":3},{"id":"GO:0045110","count":3},{"id":"GO:0035293","count":3}]},{"hash":"1665170037904964784","title":"Fatty acid metabolism and lipid biosynthesis","description":"The Top Terms show multiple fatty acid metabolic processes (long-, medium-, very long-, and other chain lengths) and the fatty acid biosynthetic process, along with lipid-related biosynthesis such as lipoteichoic acid. This indicates a cohesive theme of lipid metabolism and lipid biosynthesis across the proteins, with a few outliers (bioluminescence, seed germination) that may be incidental. ","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":5},{"id":"GO:0043041","count":4},{"id":"GO:0036112","count":4},{"id":"GO:0070395","count":4},{"id":"GO:0010030","count":4}]},{"hash":"1618667666737759164","title":"Hormone-responsive neural development and tissue morphogenesis","description":"The terms cluster neural development (positive regulation of synapse assembly; axon extension) with tissue morphogenesis and hormone-affected processes (lung connective tissue development; nipple morphogenesis; response to cortisol; FSH stimulus) and immune signaling modulation, suggesting a theme of development and remodeling governed by endocrine cues.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0060427","count":6},{"id":"GO:0060658","count":6},{"id":"GO:0050929","count":5},{"id":"GO:0051414","count":5}]},{"hash":"1231748195290256953","title":"Immune Regulation and Complement Signaling","description":"This cluster centers on immune system processes: T cell homeostasis, interleukin-10 production, complement receptor signaling, and alternative pathway activation, plus regulation of integrin activity and extrinsic apoptotic signaling. Some terms (synapse maturation) align with immune synapses, while a few terms (vocalization) appear as noise; overall, the set points to immune signaling and complement pathway involvement.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0046013","count":10},{"id":"GO:0002430","count":10},{"id":"GO:0060074","count":10},{"id":"GO:0032613","count":10},{"id":"GO:0006957","count":10}]},{"hash":"1702453006065524496","title":"Light-regulated transcription and signaling","description":"This cluster shows GO terms centered on light sensing and transcriptional regulation, including positive regulation of circadian rhythm, red/far-red light phototransduction, and far-red light signaling, plus regulation of DNA-templated transcription. These points together suggest proteins that participate in light-responsive signaling leading to transcriptional changes, with some broader signaling pathways (NF-kappaB, TNF, HIF-1alpha) contributing to regulatory context. The overarching theme is regulatory rather than enzymatic or structural, focused on light-driven transcriptional control. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042753","count":1},{"id":"GO:0009585","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0010018","count":1},{"id":"GO:0032088","count":1}]},{"hash":"1259877025817421549","title":"Chondrogenesis and Skeletal Development","description":"The top GO terms point to cartilage and connective tissue biology (chondrocyte differentiation, skeletal system development) with emphasis on cell-matrix adhesion and integrin signaling, plus ERK pathway regulation and transcriptional control, which together suggest cartilage formation and skeletal tissue development as the main theme of this cluster.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0002062","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0010763","count":3},{"id":"GO:0042535","count":3}]},{"hash":"1859529239186539687","title":"Dendritic cell differentiation and innate immune signaling","description":"The top GO terms point to immune-related processes, including follicular dendritic cell differentiation, regulation of inflammatory cytokines (IL-12, MIP-1alpha), and NOD1 signaling, suggesting innate immune sensing and dendritic cell\u2013mediated signaling. Some terms (e.g., regulation of SA node action potential, response to heat) are less connected and may reflect broader stress responses, but the dominant theme centers on immune cell function and inflammatory signaling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0098907","count":7},{"id":"GO:0045083","count":6},{"id":"GO:0070427","count":6},{"id":"GO:2000171","count":6}]},{"hash":"1939850229810101672","title":"Dopaminergic signaling and xenobiotic stress response","description":"This cluster centers on dopaminergic synaptic transmission and responses to xenobiotic stimuli (including amphetamine), with accompanying inflammatory and cytolytic processes; regulatory terms for transcription, mRNA export, and phosphorylation suggest broader cellular control. The strongest shared theme is neuronal dopamine signaling linked to xenobiotic/stress response, with additional regulatory activities.","confidence":"Medium","size":10,"edges":20,"triangles":21,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0006406","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0001963","count":3}]},{"hash":"806910015394217039","title":"Unknown","description":"The terms span diverse and largely unrelated processes (stress and xenobiotic responses, metabolism, photosynthesis, development, and transcription regulation), with no single overarching function tying the proteins together. The presence of an obsolete GO term and mixed developmental/immune signals suggests no coherent cluster theme.","confidence":"","size":10,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042493","count":3},{"id":"GO:0016042","count":2},{"id":"GO:0051384","count":2},{"id":"GO:0015979","count":2}]},{"hash":"1416525251743032950","title":"Unknown","description":"The top terms span diverse biological areas: central carbon metabolism (pyruvate and alanine catabolic processes), tryptophan-derived pathways (kynurenine and quinolinate biosynthesis), iron metabolism and iron-sulfur cluster assembly, vitamin B6 response, and even Notch signaling. This mix does not reveal a single cohesive function or pathway linking the proteins, suggesting a heterogeneous cluster rather than a defined biological module.","confidence":"","size":10,"edges":25,"triangles":19,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042866","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0009089","count":2}]},{"hash":"1168573459525627017","title":"Folate-driven one-carbon metabolism and serine biosynthesis","description":"Based on the GO terms, the proteins are enriched for L-serine biosynthesis and catabolism, tetrahydrofolate interconversion and folate metabolism, and purine biosynthetic processes, all hallmarks of folate-dependent one-carbon metabolism feeding nucleotide synthesis. The inclusion of cellular responses to tetrahydrofolate and related interconversions supports a cohesive theme around one-carbon unit provisioning for purine synthesis, with translation regulation and protein tetramerization as possible ancillary regulatory features.","confidence":"High","size":10,"edges":33,"triangles":60,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006564","count":3},{"id":"GO:0019552","count":3},{"id":"GO:0009113","count":2},{"id":"GO:0046655","count":2},{"id":"GO:0017148","count":2}]},{"hash":"1186284801360683550","title":"DNA replication, repair, and transcriptional regulation","description":"The terms are dominated by nuclear nucleic-acid processes: DNA replication, nucleotide-excision repair, and positive regulation of transcription by RNA polymerase II, with some related RNA processing and protein import terms. The inclusion of viral genome replication likely reflects shared replication machinery annotations rather than a viral-specific function. Overall, this cluster seems to represent DNA replication and genome maintenance with transcriptional control.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0045944","count":5},{"id":"GO:0019079","count":5},{"id":"GO:0017038","count":4},{"id":"GO:0060303","count":4}]},{"hash":"1594279366270973017","title":"Proteoglycan Biosynthesis and ECM Remodeling","description":"The cluster\u2019s top GO terms are dominated by proteoglycan metabolism and keratan sulfate proteoglycan biosynthesis, pointing to extracellular matrix components. Additional terms on angiogenesis in wound healing and acute inflammatory response support a theme of ECM remodeling during development and repair, with some neuronal-development terms likely reflecting proteoglycan roles in the nervous system.","confidence":"High","size":10,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0006029","count":3},{"id":"GO:0060058","count":3},{"id":"GO:0002526","count":3},{"id":"GO:0060055","count":3}]},{"hash":"807437211741785922","title":"Diverse Metabolic Pathways","description":"Top GO terms cover a range of metabolic activities, including various biosynthetic processes (carnitine, uridine, D-ribose, clavulanic acid, antibiotic biosynthesis) and catabolic reactions (xanthine degradation, 2,4-dichlorophenoxyacetic acid degradation), plus non-oxidative PPP and a cold response. Because no single pathway dominates and the terms span multiple metabolic routes, the cluster reflects broad metabolic capabilities rather than a specific function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045329","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0009052","count":1},{"id":"GO:0046109","count":1},{"id":"GO:0006014","count":1}]},{"hash":"1018947261087062936","title":"Amino acid and polyamine metabolism","description":"Most of the top GO terms describe metabolic pathways for amino acids and related amines (L-arginine biosynthesis, putrescine catabolism/acetylation, ectoine biosynthesis, acetoin catabolism), suggesting a metabolic/biochemical cluster. A few terms reference nuclear processes (subtelomeric heterochromatin formation, mitotic cohesion) or other processes (angiogenesis), which appear as outliers that may reflect annotation noise but do not dominate the cluster. Overall, the metabolic theme is the best representative signal.","confidence":"Low","size":10,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":5},{"id":"GO:0006526","count":4},{"id":"GO:0045150","count":4},{"id":"GO:0019491","count":4},{"id":"GO:0032920","count":4}]},{"hash":"1318967189838692209","title":"Transmembrane Transport of Small Molecules","description":"The proteins show diverse transmembrane transport activities across substrates such as galactose, vitamins, sialic acid, fucose, nitrate/nitrite, and xenobiotics, with an additional vesicle-related neurotransmitter loading term, suggesting a common function in moving small molecules across membranes. This theme justifies a membrane-transport-centric label, though the substrate variety tempers specificity. ","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1990592","count":1},{"id":"GO:0033146","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0015757","count":1},{"id":"GO:0015739","count":1}]},{"hash":"2297124082639515322","title":"Unknown","description":"The terms span apoptosis, development, and bacterial cell-wall/glycosylation processes, with no clear unifying function across all proteins, suggesting a heterogeneous or mixed set of annotations rather than a cohesive cluster.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902108","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0007427","count":2},{"id":"GO:0035289","count":2},{"id":"GO:0046011","count":2}]},{"hash":"48130674311462852","title":"Nuclear Transcription Regulators and Redox/ER Stress","description":"This cluster centers on nuclear transcription regulation, with terms for DNA-templated transcription, DNA binding, and negative regulation of transcription by RNA Pol II, suggesting core transcriptional control. It also includes redox/homeostasis and ER-associated processes (deglyothionylation, protein folding in ER, oxidant detoxification) and modest hints at nuclear transport regulation, indicating a link between transcriptional regulation and redox/ER stress responses. The viral process term may reflect host factors involved in viral interactions rather than a defining theme, but the dominant signal is nuclear transcription regulation coupled to redox/ER-related modulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0045454","count":5},{"id":"GO:0046826","count":5},{"id":"GO:0043388","count":5},{"id":"GO:0000122","count":5}]},{"hash":"1106835270588784455","title":"Neuronal signaling and synaptic plasticity","description":"The terms cluster around neural communication and plasticity: excitatory postsynaptic potential, long-term potentiation, calcium and potassium transport, Rac signaling and cytoskeletal remodeling, startle response, and circadian regulation of sleep. These point to a module of synaptic signaling and neuronal adaptability, with ossification as a minor outlier.","confidence":"High","size":10,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0001964","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0043149","count":2},{"id":"GO:0045188","count":2}]},{"hash":"1231724791854409256","title":"Unknown","description":"The GO terms are highly diverse, including morphine response, prostate gland development, interferon-alpha response, mitotic transition, protein isomerization, ER stress-related translation, cytokinin signaling, and hydrogen peroxide response. This mix spans animal, plant, and immune contexts with no clear shared function, suggesting no cohesive theme for a specific label.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":2},{"id":"GO:0030850","count":1},{"id":"GO:0035457","count":1},{"id":"GO:0007091","count":1},{"id":"GO:0000413","count":1}]},{"hash":"147008702211868268","title":"Neuronal development and vesicle trafficking","description":"The terms show a mix of neural development cues (forebrain radial glial differentiation, ephrin receptor signaling, and synapse plasticity regulation) along with vesicle trafficking processes (COPII cargo loading and endosome localization). This suggests a module where neuronal differentiation and synaptic signaling are closely linked with membrane trafficking roles, supporting neural growth, polarity, and synaptic maturation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090110","count":2},{"id":"GO:0043652","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0051835","count":2},{"id":"GO:0090263","count":2}]},{"hash":"1382823333107199405","title":"Ribosome Biogenesis and tRNA Modification","description":"The cluster is dominated by GO terms for ribosome biogenesis and ribosomal subunit biogenesis, plus tRNA modification, indicating a cohesive role in ribosome assembly and RNA processing; other terms like mitochondrial organization and cell cycle are present but less central to the core ribosome-related signal.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:1903833","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0042274","count":3},{"id":"GO:1901001","count":3}]},{"hash":"788247345049417888","title":"Developmental Regulation","description":"Top terms point to developmental processes across tissues (heart, kidney, embryo implantation) and transcriptional/signal regulation, implying a role in developmental regulation and gene expression rather than a single pathway; the diversity and lack of network edges support a broad, heterogeneous set.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0061000","count":2},{"id":"GO:0001822","count":2}]},{"hash":"1272220904645588078","title":"Neural signaling and barrier transport","description":"Based on GO terms, the cluster is enriched for nerve impulse transmission, ionotropic glutamate receptor signaling, neuromuscular junction development, and transport across barrier (blood-brain and blood-nerve). This suggests a coherent theme around neural communication and barrier/transport functions, with some additional regulatory terms that are peripheral to the main theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":2},{"id":"GO:0050819","count":2},{"id":"GO:0001558","count":2},{"id":"GO:0060857","count":1},{"id":"GO:0019226","count":1}]},{"hash":"700737149043767855","title":"RNA Pol II Transcription Regulation","description":"The top GO terms are dominated by RNA polymerase II\u2013related processes: transcription by RNA Pol II, transcription initiation complex assembly, regulation of transcription elongation by RNA Pol II, and transcription antitermination, indicating a focus on transcription control. A few other terms (apoptotic signaling, CoA biosynthesis) seem peripheral or older annotations. Overall, the cluster appears to represent components involved in regulating RNA Pol II\u2013mediated transcription.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097190","count":2},{"id":"GO:0046940","count":2},{"id":"GO:0046939","count":2},{"id":"GO:0015937","count":2},{"id":"GO:2001253","count":1}]},{"hash":"1023992417277477964","title":"Xenobiotic and alkaloid metabolism","description":"This cluster is dominated by GO terms for detoxification and metabolism of foreign compounds (insecticide metabolism, isoquinoline alkaloid metabolism, dibenzo-p-dioxin catabolic process, cholesterol catabolic process, alkaloid catabolic process), with related environmental-response terms (response to cesium/ potassium ions, response to food). The pattern points to genes involved in xenobiotic/alkaloid detoxification and broader metabolic processing of various compounds. Some terms may be annotation noise (e.g., prostate gland growth), but the prevailing theme supports a detox/metabolism function.","confidence":"Medium","size":10,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":8},{"id":"GO:0017143","count":8},{"id":"GO:0033076","count":8},{"id":"GO:0019341","count":8},{"id":"GO:0006707","count":8}]},{"hash":"113751795554000589","title":"Cell migration and cytoskeletal remodeling","description":"The top GO terms are dominated by processes tied to cell movement and cytoskeletal dynamics\u2014fibroblast migration, angiogenesis, platelet aggregation, substrate adhesion-dependent spreading, and sarcomere organization\u2014suggesting a cluster focused on motility and structural remodeling. Some terms are less directly related (associative learning, viral process, antibiotic response), but the prevailing theme is cellular motility and adhesion.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036120","count":3},{"id":"GO:0006909","count":3},{"id":"GO:0010763","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0070527","count":3}]},{"hash":"82411676772353541","title":"Developmental Regulation and Gene Expression","description":"The Top Terms show a concentration of developmental processes across different organisms (pituitary gland development, plant ovule morphogenesis, neuron differentiation, eclosion) alongside core regulatory activities (RNA polymerase II transcription, miRNA-mediated gene silencing, NFAT signaling). This suggests a cohesive theme around how development is coordinated with transcriptional and post-transcriptional regulation and signaling, with some peripheral metabolism-related term (sulfur oxidation) likely secondary. Overall, the cluster appears to reflect developmental regulation and gene expression control.","confidence":"Medium","size":10,"edges":14,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0045805","count":4},{"id":"GO:0042789","count":4},{"id":"GO:0046013","count":4},{"id":"GO:0048482","count":4}]},{"hash":"1776690339406204772","title":"Ubiquitin-Dependent Proteolysis in Immune and Cell Cycle","description":"This cluster centers on ubiquitin-mediated regulation of protein degradation (autoubiquitination, ubiquitin-dependent catabolic processes, APC-dependent pathways) and includes immune/antiviral defense terms, plus mitosis-related processes and microtubule localization. The combination suggests proteins that link protein turnover to both innate immune signaling and cell-cycle control.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0035372","count":4}]},{"hash":"1159947193847633744","title":"NOD1/2 Innate Signaling and Cytokine Regulation","description":"The cluster shows GO terms centered on NOD1 and NOD2 signaling, including NOD1/2 pathways, regulation of IL-12 production, and macrophage chemokine (MIP-1\u03b1) production, along with follicular dendritic cell differentiation. Together these indicate innate immune signaling and cytokine regulation, despite some ambiguous or obsolete terms (e.g., SA node GPCR signaling, NF-kappaB regulation). ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0098907","count":6},{"id":"GO:0032088","count":6},{"id":"GO:0070431","count":6},{"id":"GO:0045083","count":5}]},{"hash":"1844932638640014815","title":"GABAergic circadian sleep and locomotor signaling","description":"This cluster is dominated by circadian sleep regulation terms (both non-REM and REM) and neural signaling components, notably GABAergic signaling and ion transport that shape neuronal excitability, which tie to locomotor behavior, startle responses, and associative learning.","confidence":"High","size":10,"edges":18,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045188","count":9},{"id":"GO:0001964","count":9},{"id":"GO:0098703","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0007214","count":8}]},{"hash":"251899245744505541","title":"Unknown","description":"The GO terms point to multiple, unrelated developmental and metabolic processes (blood formation, limb and neuron development, ovarian follicle development, cholesterol synthesis) and apoptotic regulation, with no clear shared function or interaction. With no edges and only sparse, unconnected annotations, there is no cohesive theme to name; thus Unknown with no confidence.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030097","count":1},{"id":"GO:0006695","count":1},{"id":"GO:0035108","count":1},{"id":"GO:2001240","count":1},{"id":"GO:0097296","count":1}]},{"hash":"1668495297205617139","title":"Neuronal development and synaptic signaling","description":"These proteins are annotated predominantly with neural processes: axonogenesis, excitatory postsynaptic potential, long-term memory, and calcium ion transport, all pointing to neuronal development and synaptic signaling. A smaller set of terms relates to immune signaling and NF-kappaB regulation, which may reflect modulatory neuroinflammatory roles rather than core function. Overall, the dominant theme is neuron development and synaptic communication.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0007616","count":2},{"id":"GO:0060079","count":2}]},{"hash":"1943683921462471574","title":"Unknown","description":"The top GO terms are diverse, covering proteasome assembly, calcium signaling in cardiac contraction, GPCR signaling, apoptosis regulation, NF-kappaB signaling, peroxisome import, gas vesicle organization and protein hexamerization. Because these functions span disparate processes and there isn't a common biological theme linking the proteins, there isn't a clear, single label that represents the cluster.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070682","count":2},{"id":"GO:0010881","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0006919","count":2},{"id":"GO:0043123","count":2}]},{"hash":"306042979139182163","title":"Retroviral DNA Integration and Transposon Activity","description":"The cluster is dominated by GO terms for DNA integration, DNA transposition, and retrotransposition, with multiple entries mentioning proviral latency, which points to retroelements and viral genome integration. Additional terms about viral entry into the host nucleus and symbiont-mediated host interactions further reflect host-association steps characteristic of retroviral/viral infection processes. Together, these terms suggest a cohesive theme of genome-integrating elements and their interactions with host cells. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0006313","count":5},{"id":"GO:0032197","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0039651","count":5}]},{"hash":"608829944280239636","title":"Immune cell adhesion and cytoskeletal signaling","description":"The cluster is dominated by GO terms related to cell adhesion, integrin and Rho signaling, and lamellipodium assembly, which together point to cytoskeletal remodeling and migration in immune cells. Additional terms for B cell receptor signaling, NK cell cytotoxicity, and neutrophil chemotaxis reinforce an immune-migration theme, while epithelial adhesion adds a broader cell adhesion context. An outlier term for neuron projection development suggests shared cytoskeletal dynamics across cell types, but the core theme remains immune cell signaling and movement.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0030032","count":1},{"id":"GO:0090136","count":1}]},{"hash":"1197089617763494812","title":"Cardiac calcium and cAMP signaling","description":"Based on the GO terms, the proteins cluster around cardiac signaling and calcium/cAMP pathways, including activation of adenylate cyclase, calcium release, protein phosphorylation, and regulation of cardiac muscle contraction and heart development; other terms like visual perception or amphetamine response appear less central. This suggests a cardiac signaling theme with moderate confidence due to some noise from non-cardiac terms.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001975","count":7},{"id":"GO:0051281","count":7},{"id":"GO:0008284","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0043950","count":7}]},{"hash":"2015215531888811336","title":"Neural synaptic signaling and ion transport","description":"This cluster centers on GO terms tied to neural communication and ion flow across membranes: locomotory behavior, GABA signaling, sodium and potassium ion transmembrane transport, excitatory postsynaptic potential, and transmission of nerve impulses. These collectively point to proteins involved in synaptic transmission and ion-channel regulation. The inclusion of learning-related (conditioned taste aversion) and circadian sleep/wake cycle terms, plus regulation of drug response and amyloid-beta formation, suggests broader involvement in neuronal plasticity and brain signaling pathways. Overall, the pattern best fits a neural signaling/ion transport theme.","confidence":"High","size":10,"edges":12,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":9},{"id":"GO:0007214","count":9},{"id":"GO:0035725","count":9},{"id":"GO:0001661","count":9},{"id":"GO:0060079","count":9}]},{"hash":"779879503792605438","title":"Drosophila Developmental and Apoptosis Regulation","description":"This cluster centers on developmental processes (posterior head segmentation; regulation of oskar mRNA translation; open tracheal system) and apoptotic pathways (apoptotic process; regulation of mitochondrial membrane permeability in apoptosis). While some metabolic GO terms appear, the dominant themes are insect development and programmed cell death, suggesting proteins involved in developmental regulation with apoptosis modulation rather than a single metabolic pathway.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0061026","count":1},{"id":"GO:0007018","count":1},{"id":"GO:0006006","count":1},{"id":"GO:0033499","count":1}]},{"hash":"2185321091315051564","title":"Neural and Muscle Development with Transcriptional Regulation","description":"This cluster is enriched for neural and muscle developmental terms (substantia nigra development, skeletal muscle fiber development, Schwann cell development, vascular branching in development), suggesting a broad developmental program across neural, glial, and muscle lineages. The presence of transcriptional/ translational control terms (RNA Pol II termination, exosome-dependent processes, and eIF2 alpha dephosphorylation) alongside DNA replication indicates coordination of proliferation and differentiation typical of developing tissues. The neural-context term \u201cresponse to cocaine\u201d further supports a neural/pharmacological relevance within this developmental framework.","confidence":"Medium","size":9,"edges":29,"triangles":45,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0021762","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0070940","count":3},{"id":"GO:0030847","count":3},{"id":"GO:0036496","count":3}]},{"hash":"2242393728508139507","title":"RNA Modification and Ribosome Biogenesis","description":"The cluster is enriched for GO terms related to RNA modification and ribosome assembly, including rRNA/tRNA methylation, peptidyl methylation, rRNA modification, and small subunit export from the nucleus, which together point to RNA processing and ribosome biogenesis. An outlier term (nodulation) is present but does not fit the core theme. Overall, the proteins likely participate in RNA modification processes linked to ribosome production.","confidence":"High","size":9,"edges":16,"triangles":10,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0018027","count":5},{"id":"GO:0031167","count":5},{"id":"GO:0018013","count":5},{"id":"GO:0018023","count":3},{"id":"GO:0000183","count":3}]},{"hash":"225223770278797911","title":"Mitotic Spindle Assembly and Microtubule Organization","description":"The cluster is dominated by GO terms on spindle assembly, microtubule nucleation and organization, cytokinesis, and cell division, indicating proteins involved in mitosis and cytoskeletal dynamics; one neuron migration term can reflect microtubule-based movement but the core theme is spindle and microtubule dynamics.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051256","count":9},{"id":"GO:1905792","count":9},{"id":"GO:0007020","count":9},{"id":"GO:0051258","count":9},{"id":"GO:1903087","count":9}]},{"hash":"714105327326932575","title":"RNA modification and ribosome biogenesis","description":"The top GO terms are dominated by RNA modification (tRNA wobble uridine modification, tRNA methylation, rRNA modification) and ribosome-related processes (ribosomal small subunit export from nucleus), complemented by polyamine biosynthesis which supports ribosome function. While a few terms such as nodulation, antibiotic biosynthetic process, LPS response, and cellular senescence appear, they are less represented and likely incidental to the core RNA-processing/ribosome assembly theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002098","count":5},{"id":"GO:0030488","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0000154","count":3},{"id":"GO:0000056","count":3}]},{"hash":"1153020803366459210","title":"TLR/MyD88-LPS Innate Immune Signaling","description":"The enrichment centers on Toll-like receptor pathways (notably TLR4) and MyD88-dependent signaling in response to lipopolysaccharide, plus related receptor tyrosine kinase signaling, which collectively point to innate immune sensing and inflammation. Some terms related to neural processes appear as outliers, but the core theme is TLR-mediated immune signaling.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0007190","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0002755","count":2},{"id":"GO:0019800","count":2}]},{"hash":"443973876424796178","title":"Bacterial lipid and cell-envelope biosynthesis","description":"The top GO terms cluster around lipopolysaccharide biosynthesis, lipoteichoic acid biosynthesis, and multiple fatty acid metabolic and biosynthetic processes, suggesting a shared theme of envelope lipid construction in bacteria. Some terms (seed germination, bioluminescence, NRPS activation) seem unrelated, likely noise, but the dominant signal points to lipid- and cell-surface component biosynthesis. Edges are absent, so the group may comprise related but not tightly connected proteins, yet the core theme remains envelope lipid biosynthesis.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":3},{"id":"GO:0043041","count":3},{"id":"GO:0036112","count":3},{"id":"GO:0070395","count":3},{"id":"GO:0010030","count":3}]},{"hash":"652777614748877322","title":"Cardiac conduction system signaling and heart development","description":"This cluster centers on cardiac electrophysiology and heart morphogenesis, with terms for SA node and atrial action potential regulation, Purkinje signaling to ventricular myocytes, outflow tract morphogenesis, and calcium handling in the sarcoplasmic reticulum, plus calcium-responsive signaling and stress-induced hypertrophy. Occasional ossification and skin development terms are likely less relevant incidental associations.","confidence":"High","size":9,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":6},{"id":"GO:0006469","count":6},{"id":"GO:0098907","count":6},{"id":"GO:0098910","count":5},{"id":"GO:0043588","count":5}]},{"hash":"1304829213011999953","title":"Embryonic Development and Tissue Differentiation","description":"The GO terms show a common theme of developmental processes across multiple tissues (heart, skeletal, gonadal, neural) with retinoic acid signaling and differentiation/transcription as core mechanisms. While there is a stray immune term (lipopolysaccharide response), the predominant pattern is tissue development and lineage differentiation, including chondrocyte growth, adipogenesis, and DNA-templated transcription.","confidence":"Medium","size":9,"edges":9,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0060068","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0071300","count":3},{"id":"GO:0003430","count":3}]},{"hash":"2273040319815024646","title":"Immune signaling and transcriptional response","description":"Multiple top GO terms point to stimulus-induced signaling (lipopolysaccharide response, T cell receptor signaling, GM-CSF response) and downstream DNA-templated transcription, with additional signals related to peptide hormones and metallopeptidase regulation. Some terms also touch on development-related processes (mesoderm formation, budding growth), suggesting the cluster reflects cells coordinating signal-activated transcription in immune and developmental contexts.","confidence":"Medium","size":9,"edges":17,"triangles":11,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0097011","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0046827","count":7}]},{"hash":"680644787715008989","title":"Lung Development and Metabolic Stress Response","description":"The cluster shows a mix of metabolic processes (retinol metabolism, fatty acid biosynthesis, TCA cycle) and broad stress- or stimulus-response terms (lipopolysaccharide, herbicide, zinc ion, amino acid, insulin). The presence of a lung development term hints tissue context, but the dominant theme appears to be metabolism with accompanying stress signaling, suggesting a group of metabolic enzymes and stress-responsive proteins potentially relevant to lung physiology.","confidence":"Medium","size":9,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042572","count":3},{"id":"GO:0071222","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0009635","count":2}]},{"hash":"1281766384336060364","title":"Ribosome Biogenesis and Translation","description":"Most terms center on ribosome assembly and protein synthesis\u2014translation, cytoplasmic translation, ribosome biogenesis, tRNA modification, and export of ribosomal subunits\u2014indicating a ribosome-related functional cluster. A few terms touch on cell division and stress responses, but translation and ribosome biology dominate.","confidence":"High","size":9,"edges":26,"triangles":35,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0042254","count":4},{"id":"GO:0006400","count":4},{"id":"GO:0002181","count":4},{"id":"GO:1903833","count":3}]},{"hash":"2247155055984505370","title":"Embryonic and organ morphogenesis","description":"The top GO terms are dominated by embryonic development and organ morphogenesis across tissues (e.g., in utero embryonic development, pancreas morphogenesis, embryonic eye morphogenesis, cardiac muscle morphogenesis). This points to a cluster of proteins involved in developmental tissue formation across multiple organs, with a few peripheral terms like neuron maturation and response to lipopolysaccharide that are less central to the main theme.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":4},{"id":"GO:0042551","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0001547","count":2},{"id":"GO:0055010","count":2}]},{"hash":"1687106842912331512","title":"Chromatin remodeling and RNA processing regulators","description":"The GO terms cluster around regulation of RNA processing (ncRNA-mediated silencing and splicing) together with chromatin dynamics (chromatin remodeling and histone acetylation) and DNA topology changes, pointing to a shared role in controlling gene expression through coordinated chromatin state and RNA processing; a few miscellaneous terms reflect broader nuclear processes rather than a tight core function.","confidence":"Medium","size":9,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0048026","count":2},{"id":"GO:2000616","count":1},{"id":"GO:1990120","count":1},{"id":"GO:0006265","count":1}]},{"hash":"813988823899956803","title":"Insect Neuropeptide Signaling and Behavioral Regulation","description":"The terms cluster around neural signaling and behavior in insects, including neuropeptide signaling, larval locomotion, mating-related behaviors, and neuromuscular transmission. This suggests a core theme of neural-control of behavior, with ancillary notes on xenobiotic transport and copper homeostasis that may reflect general cellular maintenance rather than core function.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901045","count":1},{"id":"GO:0010459","count":1},{"id":"GO:0007218","count":1},{"id":"GO:0002209","count":1},{"id":"GO:0008345","count":1}]},{"hash":"2177490413833201244","title":"Cytoskeletal dynamics and cell adhesion","description":"The top terms cluster around regulation of integrin-mediated adhesion, actin cytoskeleton remodeling (stress fibers, brush border), and processes dependent on cytoskeletal rearrangements such as synapse plasticity and phagolysosome assembly. This points to a shared theme of cytoskeletal dynamics linked to cell\u2013matrix/cell\u2013cell adhesion across diverse contexts (including epithelial and sensory cell structures). While some terms are more specific to particular tissues, the overarching link is cytoskeleton\u2013adhesion biology.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051835","count":2},{"id":"GO:0033628","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0050957","count":2}]},{"hash":"1275150213795476491","title":"Multi-tissue development and differentiation","description":"This cluster centers on differentiation and development across several tissues (Sertoli cells, cardiac ventricle, vascular smooth muscle, uterus), with supporting regulatory processes such as protein sumoylation and DNA repair, suggesting a broad developmental theme rather than a single tissue-specific function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0060008","count":3},{"id":"GO:0030263","count":3},{"id":"GO:2001015","count":3},{"id":"GO:0035886","count":3},{"id":"GO:0016925","count":3}]},{"hash":"452708476013456702","title":"Unknown","description":"The terms span ER protein folding/quality control and stress response, redox homeostasis, and separate developmental processes such as mesoderm formation and Hedgehog-related signaling, with an additional cilia-related assembly term. This blend shows no single coherent function linking all proteins, so a specific label isn\u2019t supported.","confidence":"","size":9,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006784","count":1},{"id":"GO:1901621","count":1},{"id":"GO:0001707","count":1},{"id":"GO:1904158","count":1},{"id":"GO:0036494","count":1}]},{"hash":"1883676056418798113","title":"Multisystem Developmental Signaling","description":"The GO terms mix signaling pathways (aba-activated, Wnt), neural and synaptic activity (long-term potentiation, glutamatergic transmission), muscle and skin differentiation (myoblast fusion, keratinocyte differentiation), and general regulation of apoptosis and lipid biosynthesis. There isn\u2019t a single, cohesive pathway but rather a broad theme of development- and differentiation-related signaling across multiple tissues. This makes Multisystem Developmental Signaling a concise, representative label.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009738","count":6},{"id":"GO:0007520","count":6},{"id":"GO:0060291","count":6},{"id":"GO:0043065","count":6},{"id":"GO:0035249","count":5}]},{"hash":"1998490920236085206","title":"Detoxification and xenobiotic metabolism","description":"The top GO terms cluster around catabolic and metabolic processes for xenobiotics and lipids (alkaloids, insecticides, dibenzo-p-dioxin, cholesterol). This suggests the proteins collectively function in detoxification and metabolism of foreign compounds and lipid-derived substrates, rather than a single, narrow pathway. Confidence: High","confidence":"","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0060736","count":4},{"id":"GO:0017143","count":4},{"id":"GO:0033076","count":4},{"id":"GO:0019341","count":4}]},{"hash":"1081896665099215173","title":"Circadian calcium signaling in auditory pathways","description":"The top GO terms point to calcium dynamics (import and release) and ion transport, together with sensory perception of sound and startle response, plus regulation of circadian sleep/wake cycles (including REM/non-REM). This suggests a cluster of proteins involved in calcium- and ion-dependent signaling in auditory/sensory neurons that also participate in circadian regulation, with some terms (e.g., amyloid-beta formation) as less central bystanders. Confidence in a single cohesive theme is moderate due to some broader or less-connected terms, hence a focused label around circadian/calcium signaling in auditory pathways.","confidence":"Medium","size":9,"edges":16,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":4},{"id":"GO:0045188","count":4},{"id":"GO:0098703","count":4},{"id":"GO:0050910","count":4},{"id":"GO:0035584","count":3}]},{"hash":"1194302207349314802","title":"Embryonic development and organ morphogenesis","description":"This cluster\u2019s top GO terms cluster around developmental processes and tissue formation, including cartilage morphogenesis, placental/embryonic differentiation, endocrine and pancreatic development, left-right patterning, and EMT in heart development. While a couple of terms touch on metabolism or plant-specific processes, the dominant theme is embryonic development and organ morphogenesis across diverse lineages.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060806","count":3}]},{"hash":"547653849734755097","title":"Unknown","description":"The terms span spermatogenesis and spermatid development, melanocyte differentiation, immune response, mechanosensory behavior, and RNA processing/export processes, with no clear single function tying them together. This diversity suggests there is no cohesive biological theme for this cluster, so I label it Unknown.","confidence":"","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":1},{"id":"GO:0007286","count":1},{"id":"GO:0006955","count":1},{"id":"GO:0007638","count":1},{"id":"GO:0045071","count":1}]},{"hash":"2157748386319576355","title":"Developmental signaling and epithelial morphogenesis with immunity","description":"This cluster combines terms tied to developmental signaling (BMP pathway), tissue morphogenesis across various organs (otolith, salivary gland branching, GI epithelium maintenance, myelination, synapse assembly), and innate immune responses (complement activation, innate immunity). The common thread appears to be signaling-driven development and morphogenesis with ancillary immune-related roles, rather than a single narrowly defined function. Confidence: Medium","confidence":"","size":9,"edges":11,"triangles":4,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":5},{"id":"GO:0030513","count":4},{"id":"GO:0030277","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0007157","count":4}]},{"hash":"2103623804206447087","title":"SNARE-Mediated Vesicle Trafficking and Exocytosis","description":"This cluster centers on vesicle transport and fusion involving the Golgi and ER, SNARE complex assembly, and exocytic processes, including neurotransmitter receptor insertion and immune cell degranulation, reflecting a cohesive vesicle trafficking/exocytosis theme.","confidence":"High","size":9,"edges":11,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0090161","count":4},{"id":"GO:0098967","count":4},{"id":"GO:0006891","count":4}]},{"hash":"693465964013675340","title":"Ribosome biogenesis and rRNA maturation","description":"The proteins are enriched for maturation and processing steps of SSU and LSU rRNA from the tricistronic rRNA transcript, plus multiple ribosome biogenesis terms (including ITS1 cleavage and large subunit maturation), indicating a cohesive role in ribosome assembly. Some development terms appear as minor context, but the core signal is ribosome biogenesis and rRNA maturation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000462","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0000466","count":2}]},{"hash":"620377420243206492","title":"Tissue morphogenesis and ECM organization","description":"The proteins are linked to development and morphogenesis of multiple tissues (tendon, aorta smooth muscle, AV valve, oviduct) and to extracellular matrix organization (collagen fibrils) and cell adhesion, suggesting a shared role in tissue formation and ECM remodeling. Some terms appear peripheral, but the core theme centers on morphogenesis and ECM. ","confidence":"Medium","size":9,"edges":9,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035989","count":1},{"id":"GO:0051497","count":1},{"id":"GO:0003190","count":1},{"id":"GO:0034381","count":1},{"id":"GO:0060414","count":1}]},{"hash":"1725194669087525564","title":"Diverse Metabolite Biosynthesis","description":"The top GO terms point to biosynthetic and catabolic processes across a broad set of metabolites (antibiotics, anthocyanin compounds, retinal, tetrahydrobiopterin, estrogens, steroids, androgens, poly-hydroxybutyrate, etc.), suggesting a common theme of diverse small-molecule production and turnover. The presence of an outlier term like lung development makes the cluster moderately heterogeneous, but metabolism-related terms predominate.","confidence":"Medium","size":9,"edges":29,"triangles":45,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0009718","count":6},{"id":"GO:0030324","count":5},{"id":"GO:0045150","count":5},{"id":"GO:0042619","count":5}]},{"hash":"618016519582698858","title":"Skeletal development and ECM assembly","description":"This cluster\u2019s top GO terms cluster around extracellular matrix components and development-related processes: cell-matrix adhesion, elastic fiber assembly, bone trabecula formation, growth plate cartilage development, and ventricular septum development, all pointing to ECM organization and skeletal/cardiac development. Some terms (antibiotic biosynthetic process, sporulation) appear as noise or cross-species annotations, but the dominant signal ties to ECM and tissue development, supporting a label focused on skeletal development and ECM involvement.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0072378","count":2}]},{"hash":"2276466730452668005","title":"Neurovascular development","description":"The top GO terms cluster around neural development and vascular formation, including CNS development, angiogenesis, myelination, organ induction, heart development, and synapse-related processes, with otolith morphogenesis as a sensory organ development example. This points to coordinated neural and vascular patterning and maturation, i.e., neurovascular development. The innate immune term is less central but can appear in developmental contexts, not weakening the overall theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0032474","count":4},{"id":"GO:0045087","count":4}]},{"hash":"1486439055943389331","title":"Immune signaling and cell migration regulation","description":"The cluster centers on immune-related signaling (interleukin responses, NK T cell differentiation, hematopoiesis) and processes tied to cell movement and cytoskeleton (lamellipodium assembly, small GTPase signaling), suggesting a theme of how immune signaling interfaces with cell migration and actin dynamics.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":3},{"id":"GO:1904140","count":3},{"id":"GO:0030097","count":3},{"id":"GO:0098761","count":3},{"id":"GO:0007264","count":3}]},{"hash":"290948276188878125","title":"Retroviral DNA Integration and Replication","description":"The top GO terms point to steps in a retroviral life cycle: integration of viral DNA into the host genome, establishment of proviral latency, penetration of the host nucleus, RNA-templated DNA synthesis (reverse transcription), and DNA replication/recombination. While some terms reference general symbiont-host interactions, the convergence on DNA integration and reverse transcription strongly supports a retroviral\u2013style functional theme for this cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0075713","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0075732","count":3}]},{"hash":"769736390443465758","title":"Unknown","description":"The top GO terms cover immune regulation (T cell homeostasis, monocyte differentiation), stress and energy-related processes (response to freezing, ATP generation from PAR), protein modification and turnover (ADP-ribosylation, peroxisome autophagy, transport), and general cellular processes, with no single cohesive function linking all nine proteins. This diversity makes it hard to assign a specific, representative label, so Unknown is most appropriate.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":2},{"id":"GO:0050774","count":2},{"id":"GO:1990966","count":2},{"id":"GO:0006471","count":2},{"id":"GO:0045657","count":2}]},{"hash":"1939672795022308820","title":"Neuronal actin remodeling and vesicle trafficking","description":"The GO terms point to actin cytoskeleton dynamics (Arp2/3-mediated nucleation, actin organization, barbed-end capping) coupled with membrane remodeling and trafficking (synaptic vesicle endocytosis, neurotransmitter secretion, plasma membrane tubulation). The inclusion of cadherin-mediated adhesion suggests synaptic contact-related adhesion. Collectively, this set reflects proteins involved in actin-driven remodeling that underpins vesicle cycling and membrane changes at neuronal synapses.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000601","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0048488","count":2},{"id":"GO:0097320","count":2},{"id":"GO:0007015","count":2}]},{"hash":"1819983325473177635","title":"GPCR-cAMP Signaling in Vascular and Immune Regulation","description":"The top GO terms point to GPCR signaling that activates adenylate cyclase and raises cAMP (GO:0010579, GO:0007190), with downstream effects on vascular tone and blood pressure (GO:0045777) and modulation of pain, chemokine and cytokine production (GO:0051930, GO:0090198, GO:2000484, GO:0032651). Acetylcholine metabolism (GO:0060408) ties to neural signaling, while electron transport and photoreceptor maintenance appear as broader energy/sensory maintenance contexts. Overall, the cluster centers on GPCR-cAMP signaling coordinating vascular, neural, and inflammatory processes.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0010579","count":8},{"id":"GO:0007190","count":7},{"id":"GO:0051930","count":6}]},{"hash":"1828247570692784170","title":"Unknown","description":"The terms span diverse processes\u2014from DNA replication and translation to mitochondrial tRNA charging, plus plant-specific brassinosteroid signaling and animal-like inflammatory regulation\u2014without a single coherent functional theme across the cluster. This makes a unified, specific label unlikely.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0050728","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0009742","count":2},{"id":"GO:1903799","count":2}]},{"hash":"724903440019684618","title":"Neural Development and Signaling","description":"The terms center on neural development (cerebellar granule cell differentiation, retina development) and signaling processes (calcium release into cytosol, GTPase activity regulation, adrenergic receptor signaling). Ubiquitination and proliferation appear as broader cellular regulation components, but the strongest signal is neural differentiation and related signaling pathways, with some immune-related terms that may reflect shared signaling machinery rather than a cohesive immune function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0008284","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1461543435491519323","title":"Mesodermal Development and Muscle Differentiation","description":"The dominant GO terms are mesoderm formation, angiogenesis, and myotube differentiation, pointing to mesodermal lineage development and muscle fiber formation. Other terms about responses to stimuli are present but do not define the core function of the cluster; the primary theme appears to be developmental processes in the mesoderm/muscle lineage.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001707","count":5},{"id":"GO:0007118","count":5},{"id":"GO:1905050","count":5},{"id":"GO:0042220","count":5},{"id":"GO:0071375","count":5}]},{"hash":"1283385585763829765","title":"Ubiquitin-Proteasome System","description":"This cluster centers on ubiquitination and degradation, as shown by terms for ubiquitin-dependent protein catabolic process, autoubiquitination, and various ubiquitin linkages (K48, K63, K6), plus polyubiquitination and ERAD; histone catabolic process and TNF signaling regulation further reflect regulatory ubiquitination roles. The combined signals point to a cohesive module of ubiquitination machinery directing proteasomal degradation and related turnover processes.","confidence":"High","size":8,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0051865","count":5},{"id":"GO:0070936","count":5},{"id":"GO:0085020","count":4},{"id":"GO:1903265","count":4}]},{"hash":"2090775038750695468","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster around ribosome assembly and function\u2014rRNA maturation (5.8S and LSU/SSU), large subunit biogenesis, and translation\u2014with some ancillary protein import terms, indicating a group of proteins involved in ribosome production and protein synthesis.","confidence":"High","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0000466","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0017038","count":2}]},{"hash":"1083088761084261597","title":"Embryonic morphogenesis and organ differentiation","description":"This cluster predominantly features GO terms tied to embryonic development and tissue morphogenesis (cartilage morphogenesis, left-right pattern formation) and lineage-specific differentiation (trophoblast giant cell differentiation, endocrine system development, type B pancreatic cell development, EMT in endocardial cushion formation). The RNA processing and ribosome-related terms are ancillary and do not define the main theme. Overall, the proteins appear associated with embryonic tissue formation and organ specification.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060806","count":6}]},{"hash":"1354784366776133033","title":"Cytoskeletal remodeling and endosomal trafficking","description":"The top GO terms cluster around actin-based structures (filopodium, microspike assembly), Rho signaling regulation, and membrane remodeling (pinocytosis, membrane tubulation), plus endosomal transport and immunological synapse formation. Together these imply a group of proteins coordinating actin dynamics with vesicle trafficking, especially in immune signaling contexts. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048549","count":4},{"id":"GO:0001771","count":3},{"id":"GO:1903527","count":3},{"id":"GO:0030035","count":3},{"id":"GO:0016197","count":3}]},{"hash":"1913891132958241373","title":"RNA processing and transcription regulation","description":"The top GO terms cluster around RNA processing and transcription, including termination of RNA Pol II transcription, exon ligation and spliceosome-mediated splicing, and regulatory ncRNA\u2013mediated gene silencing. Additional terms hint at nuclear roles (protein import) and DNA replication, consistent with a set of nuclear\u2013process proteins coordinating transcription and RNA maturation. Taken together, the cluster represents RNA maturation and transcription control functions.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006369","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0017038","count":5},{"id":"GO:0060303","count":5}]},{"hash":"1017979435189405623","title":"Neurovascular development and immune regulation","description":"These terms cluster around neural development (neuron migration, regulation of synapse assembly, cell\u2013cell adhesion) together with vascular development (angiogenesis and negative regulation of VEGF signaling) and immune modulation (regulation of macrophage and T cell activity). The shared theme appears to be developmental programs coordinating nervous and vascular growth with immune regulation, i.e., neurovascular development with immune modulation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0048496","count":2},{"id":"GO:1900747","count":2},{"id":"GO:0043031","count":2},{"id":"GO:0001764","count":2}]},{"hash":"21295073040854091","title":"Muscle Calcium Handling and Ion Transport","description":"The GO terms cluster around calcium homeostasis and ion transport related to muscle function, including calcium import/export, mitochondrial calcium transport, regulation of skeletal and heart muscle contraction, and other ion transport processes. This points to a coherent theme of calcium signaling coordinating muscle excitation-contraction coupling, with some broader neuronal signaling hints (e.g., long-term potentiation) that still relate through calcium signaling pathways. Confidence: High","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098735","count":1},{"id":"GO:1990034","count":1},{"id":"GO:0014819","count":1},{"id":"GO:0098703","count":1},{"id":"GO:0010163","count":1}]},{"hash":"1702118750892177785","title":"Developmental signaling and cell cycle regulation","description":"This cluster centers on developmental processes (mesoderm formation, angiogenesis, budding growth), along with signaling modulation (hedgehog/Smoothed pathway regulation, hormone response) and core cell cycle activities (DNA replication, spindle checkpoint). The common thread appears to be proteins that link development with signaling cues and cell-cycle control.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001707","count":4},{"id":"GO:1901621","count":4},{"id":"GO:0071374","count":4},{"id":"GO:0006260","count":4},{"id":"GO:1901925","count":4}]},{"hash":"377347856158904782","title":"Spliceosome-Mediated mRNA Processing","description":"The GO terms cluster around splicing via the spliceosome (positive/negative regulation, alternative splicing) and broader mRNA processing (stability, modification, polyadenylation, translation reinitiation), plus regulatory ncRNA-mediated silencing, indicating a cohesive role in post-transcriptional regulation of mRNA.","confidence":"High","size":8,"edges":7,"triangles":2,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":6},{"id":"GO:0010610","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0045292","count":5}]},{"hash":"2003706912639737470","title":"Ubiquitination and post-translational modification","description":"Top GO terms cluster around protein ubiquitination (including K63- and K6-linked) and neddylation, pointing to a theme of post-translational modification and ubiquitin-like signaling. While other terms (viral process, JNK regulation, DNA repair) are broader or incidental, the shared thread is modification of proteins that can regulate signaling and chromatin/repair pathways. The lack of interaction edges suggests these proteins participate in diverse ubiquitin-related processes rather than a single cohesive pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":1},{"id":"GO:0070911","count":1},{"id":"GO:0046007","count":1},{"id":"GO:0060816","count":1},{"id":"GO:0070534","count":1}]},{"hash":"1677428235448236116","title":"Mitochondrial transport and metabolism","description":"Based on the GO terms, the cluster centers on mitochondrial functions, including iron import into mitochondrion, mitochondrial citrate transmembrane transport, and apoptotic mitochondrial changes. Other terms relate to membrane transport and metabolic signaling (phosphate ion transmembrane transport, thiosulfate transport, cellular response to insulin stimulus), with one term less clearly aligned (regulation of protein export from the nucleus). Overall, the mitochondrial transport/metabolism theme best explains the shared functions among these proteins.","confidence":"Medium","size":8,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":3},{"id":"GO:0008637","count":3},{"id":"GO:0035435","count":3},{"id":"GO:0046825","count":2},{"id":"GO:0071226","count":2}]},{"hash":"912700000764677386","title":"Septin ring organization and cell polarity","description":"This cluster is dominated by GO terms about septin cytoskeleton dynamics (septin ring assembly/disassembly, bud neck septin ring organization) and maintenance of cell polarity, suggesting a module centered on septin-mediated cytoskeletal organization and polarity with related roles in meiosis/spindle assembly and development.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:1903833","count":3},{"id":"GO:0030011","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0000921","count":3},{"id":"GO:0031107","count":3}]},{"hash":"28941999893524970","title":"Membrane Ion Transport and NMJ Regulation","description":"Top terms emphasize membrane transport (potassium, chloride, heme) and synaptic assembly regulation at the neuromuscular junction, with hints of cytoskeletal remodeling and glial/immune signaling. This combination suggests a cluster centered on membrane transport influencing synaptic organization and NMJ function, with possible modulatory roles from glial/immune pathways. ","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0015886","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0007019","count":2},{"id":"GO:0071346","count":2}]},{"hash":"918671104818253212","title":"NF-kappaB signaling in innate immunity","description":"This cluster centers on regulation of NF-kappaB activity and canonical NF-kappaB signaling, with supporting links to MyD88-dependent TLR signaling and broader immune processes (e.g., spleen development, IL-12 regulation). The combination of NF-kB\u2013related regulation, innate immune signaling, and modulation of inflammatory and cell death pathways suggests a cohesive role in controlling innate immune responses.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0006407","count":2}]},{"hash":"687230052948517977","title":"Vesicle trafficking and membrane remodeling","description":"The Top Terms cluster around endomembrane transport and membrane dynamics: ER-to-Golgi transport, endosome-to-lysosome transport, membrane tubulation, lipoprotein particle assembly, and epithelial cell polarity. A few terms (apoptosis and ultradian rhythm) are less connected to this core theme, suggesting mixed signals, but the dominant pattern points to vesicle formation/trafficking and membrane remodeling functions.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0033028","count":1},{"id":"GO:0034379","count":1},{"id":"GO:0090162","count":1},{"id":"GO:1902953","count":1},{"id":"GO:0035021","count":1}]},{"hash":"73676578085280964","title":"Synaptic plasticity and growth factor signaling","description":"This cluster centers on neuronal signaling: it includes regulation of short-term neuronal synaptic plasticity and regulation of AMPA receptor activity, supported by broader growth factor signaling terms (IGF receptor signaling, insulin-like growth factor receptor signaling) and downstream pathways (calcineurin-NFAT). Some terms relate to development and stress responses (bone mineralization, cardiac growth, p53-mediated apoptotic signaling), but the dominant shared theme is modulation of synaptic signaling together with growth-factor pathways.","confidence":"Medium","size":8,"edges":8,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":1},{"id":"GO:2000311","count":1},{"id":"GO:0042771","count":1},{"id":"GO:0040037","count":1},{"id":"GO:0010560","count":1}]},{"hash":"2289988403295319038","title":"Amino acid catabolism and quinone biosynthesis","description":"This cluster is enriched for amino acid catabolic processes (valine, phenylacetate), and for biosynthesis of quinone cofactors (menaquinone, phylloquinone) plus fatty acid beta-oxidation. The combination points to energy-yielding metabolism and cofactor production, with translation and ribosome biogenesis terms likely reflecting general cellular activity rather than a single tightly defined function.","confidence":"Medium","size":8,"edges":12,"triangles":8,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":4},{"id":"GO:0009234","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0006635","count":4},{"id":"GO:0042372","count":4}]},{"hash":"1860245760129382333","title":"DNA Transposition and Proviral Integration","description":"The top GO terms cluster around DNA integration, transposition, retrotransposition, and establishment of integrated proviral latency, which point to mobile genetic elements and viral integration events. Additional terms touch on virus/symbiont interactions with host cells, reinforcing a theme of genome insertion or entry processes. A few unrelated terms (plant cell wall biosynthesis) appear as noise. Overall, the cluster seems best characterized by transposon- and provirus-related functions.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006313","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2}]},{"hash":"2197944112303462486","title":"Unknown","description":"The GO terms in this cluster are highly heterogeneous, spanning muscle development, nervous system processes, circadian regulation, immune signaling, metabolism, and even plant- and virus-related processes, with only a couple of weak connections. There is no clear, single theme tying the proteins together, so a specific, meaningful label cannot be assigned.","confidence":"","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0036268","count":1},{"id":"GO:0007519","count":1},{"id":"GO:0031397","count":1},{"id":"GO:0019046","count":1},{"id":"GO:0019762","count":1}]},{"hash":"396254701329505516","title":"mRNA processing and splicing regulation","description":"The proteins cluster around spliceosome-mediated mRNA processing and regulation, including positive/negative regulation of splicing, mRNA stability under stress, and other post-transcriptional modifications. Translation reinitiation and ncRNA-mediated silencing signals also align with a broader post-transcriptional regulatory role.","confidence":"High","size":8,"edges":10,"triangles":7,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":8},{"id":"GO:0002188","count":7},{"id":"GO:0045292","count":7},{"id":"GO:0048025","count":7},{"id":"GO:1901407","count":7}]},{"hash":"242236441011828326","title":"Ubiquitin-Mediated Innate Immune Signaling","description":"The cluster is dominated by ubiquitin-dependent protein catabolism and autoubiquitination with various linkage types (K63, K6), pointing to proteasomal turnover. It also includes activation of canonical NF-kappaB signaling and innate immune responses (defense against virus, TNF signaling), linking ubiquitination to immune signaling pathways.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0051865","count":5},{"id":"GO:0070534","count":5},{"id":"GO:0043123","count":4},{"id":"GO:0085020","count":4}]},{"hash":"2189492095545721629","title":"Embryonic organogenesis and neural development","description":"The terms point to diverse organ formation and neural patterning, including pharyngeal development, telencephalon/diencephalon morphogenesis, peripheral nervous system neuron development, heart node fate, and prostate morphogenesis, with an additional note of transcriptional regulation. This suggests a cluster centered on embryonic organogenesis and neural development across multiple tissues.","confidence":"Medium","size":8,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060037","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0050905","count":3},{"id":"GO:0060929","count":3}]},{"hash":"695462614971525963","title":"Neuronal GPCR Signaling with Immune Modulation","description":"The cluster shows strong representation of GPCR signaling and neurotransmitter-related regulation (adenylate cyclase-activating pathway, acetylcholine metabolism, dopamine receptor signaling) alongside immune-related cytokine production and photoreceptor maintenance, suggesting proteins that coordinate neural signaling with immune modulation and sensory maintenance. The electron transport chain term is secondary to the central signaling theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":6},{"id":"GO:0022900","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0051930","count":5},{"id":"GO:0090198","count":5}]},{"hash":"1481419192729428934","title":"Triglyceride Catabolism & Lipid Remodeling","description":"The cluster's terms cluster around triglyceride catabolic processes and related lipid remodeling (phosphatidylcholine/ethanolamine catabolism, triglyceride mobilization). The presence of positive regulation of triglyceride catabolism and related lipid turnover points to a cohesive lipid metabolism theme; vascular/immune terms appear as secondary associations rather than core drivers.","confidence":"High","size":8,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":4},{"id":"GO:0010898","count":3},{"id":"GO:0046338","count":3},{"id":"GO:2000480","count":3},{"id":"GO:0034638","count":3}]},{"hash":"2210570530266128818","title":"Neural signaling and locomotion","description":"The top GO terms point to nervous system function and behavior: nerve impulse transmission, GABA signaling, innervation, locomotory behavior, circadian regulation of sleep/wake, and drug responses (including cocaine). While there are a few peripheral terms, the cluster is best described as a neuronal signaling and movement-control module.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":8},{"id":"GO:2001023","count":8},{"id":"GO:0042320","count":8},{"id":"GO:1902004","count":8},{"id":"GO:0051971","count":8}]},{"hash":"2170093845135929546","title":"Actin Cytoskeleton Dynamics and Organelle Inheritance","description":"The cluster is dominated by terms tied to actin remodeling and actin-driven processes (Arp2/3-mediated nucleation, actin cortical patch assembly, vacuole inheritance). Calcium signaling also modulates actin dynamics, and some meiotic movement terms likely reflect cytoskeletal involvement in chromosome transport. Overall, a cohesive theme is actin-based cytoskeleton dynamics governing intracellular transport and organelle inheritance, with a few outliers representing broader or context-specific processes.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016344","count":7},{"id":"GO:0010628","count":7},{"id":"GO:0000147","count":7},{"id":"GO:0043503","count":7},{"id":"GO:0051592","count":7}]},{"hash":"1696622292622703571","title":"Integrin signaling and cell adhesion","description":"The top GO terms cluster around integrin-mediated signaling, cell adhesion (including heterotypic adhesion) and cytoskeletal dynamics (lamellipodium morphogenesis, Rho signaling, extravasation). These together suggest a functional group focused on adhesion and migration processes. Some outlier terms (proteasome assembly, chlorophyll biosynthesis) may reflect annotation noise or cross-species data, but the dominant signal points to adhesion/signaling with cytoskeletal remodeling. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":6},{"id":"GO:0007417","count":4},{"id":"GO:2000394","count":4},{"id":"GO:0046627","count":4},{"id":"GO:0035023","count":4}]},{"hash":"63052434576771222","title":"Transcription Regulation and Signaling","description":"The cluster is dominated by GO terms related to transcription regulation (regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II) and signals such as positive regulation of GTPase activity and dendrite extension, suggesting a core theme of gene expression control intertwined with signaling pathways. Some other terms (plant-specific metabolic processes) may reflect annotation noise or multi-functional proteins across species, but do not override the central transcriptional regulation signal. Overall, the proteins seem to cluster around regulatory functions rather than a single cohesive metabolic pathway, justifying a label focused on transcription and signaling.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:1903861","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0060487","count":2}]},{"hash":"1876292680833509262","title":"Unknown","description":"Top terms are diverse and do not point to a single shared function; they span behavioral, metabolic, detoxification, plant-specific chlorophyll catabolism, P450 epoxygenase pathways, and insulin regulation, with no protein-protein edges to suggest a cohesive module. Therefore a clear, representative label cannot be defined.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001662","count":1},{"id":"GO:0042619","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0015996","count":1},{"id":"GO:0033632","count":1}]},{"hash":"1227818678490285234","title":"Epigenetic Regulation and Cell Cycle","description":"This cluster centers on chromatin-level regulation and cell division: histone modifications (H4-K16 acetylation, histone acetylation/deacetylation, H3-K4 trimethylation) and imprinting regulation imply epigenetic control of gene expression, while spindle assembly and cell cycle terms tie to mitotic processes. Although several GO terms are obsolete, the core theme points to chromatin modification activity accompanying cell-cycle progression.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006349","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0043984","count":2},{"id":"GO:0016575","count":2},{"id":"GO:0080182","count":2}]},{"hash":"1443529507829358126","title":"Vascular smooth muscle differentiation and actin remodeling","description":"The top GO terms cluster around smooth muscle lineage and vascular development (vasculogenesis, vascular-associated smooth muscle differentiation, cardiac ventricle development, uterus development) and include actin cytoskeleton dynamics (stress fiber assembly) and phenotype modulation (regulation of PDGF receptor-beta signaling, phenotypic switching). This suggests the proteins function together in smooth muscle cell differentiation and the accompanying remodeling of the actin cytoskeleton during vascular and related tissue development. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043149","count":3},{"id":"GO:0001570","count":3},{"id":"GO:0031532","count":2},{"id":"GO:2001015","count":2},{"id":"GO:0045987","count":2}]},{"hash":"2020750031321333570","title":"RNA Splicing and Processing","description":"This cluster is dominated by GO terms related to RNA maturation: RNA splicing, mRNA processing, and spliceosomal complex disassembly, with an additional hint of Box C/D snoRNP assembly. Although there is a minor reference to transcription regulation, the strongest signal is the RNA processing/splicing machinery, suggesting a cohesive role in post-transcriptional RNA processing.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0000492","count":2},{"id":"GO:0031062","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0006397","count":1}]},{"hash":"890167632709280356","title":"ER stress\u2013protein folding cluster","description":"This cluster is dominated by terms tied to the endoplasmic reticulum (ER) quality control and stress response: protein folding in the ER, ER-associated degradation, and translation initiation regulation in response to ER stress, plus associated redox and heat response terms. The remaining terms (mesoderm formation, DNA replication, and hedgehog-related signaling) are less cohesive with the ER-centric theme, suggesting the core signal is ER stress/protein folding. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901621","count":1},{"id":"GO:0001707","count":1},{"id":"GO:0036494","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0030433","count":1}]},{"hash":"1121562761297826217","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0000466","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0000472","count":2}]},{"hash":"1420429258164807806","title":"Cardiovascular development and redox balance","description":"The terms point to heart development and blood pressure regulation, along with muscle-related processes and redox/homeostatic pathways (glutathione biosynthesis/catabolism, oxidant detoxification, and hypoxia response), suggesting a cluster centered on cardiovascular/muscle function intertwined with redox regulation.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0007507","count":2},{"id":"GO:1901750","count":2},{"id":"GO:0006750","count":2},{"id":"GO:0006751","count":2}]},{"hash":"319950668849389386","title":"Actin-driven phagocytosis and antigen presentation","description":"This cluster centers on actin cytoskeleton remodeling (Arp2/3-mediated nucleation, pseudopodium assembly) coupled with immune functions like dendritic cell antigen processing/presentation and T cell proliferation, suggesting a common theme of actin-mediated phagocytosis and antigen presentation in immune cells; a few outlier terms likely reflect annotation noise.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034314","count":2},{"id":"GO:0040038","count":1},{"id":"GO:0043553","count":1},{"id":"GO:0044655","count":1},{"id":"GO:0002468","count":1}]},{"hash":"694450668108794347","title":"Unknown","description":"The GO terms are scattered across self proteolysis, autophosphorylation, glycoside response, Golgi-related Ca2+ release, vacuole organization, phospholipid translocation, cell polarity, membrane repolarization, epoxygenase P450 pathway, and copper export, with no single unifying function for these seven proteins. Because there is no coherent theme linking the top terms, a concise, representative label cannot be assigned with confidence.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097264","count":1},{"id":"GO:1990938","count":1},{"id":"GO:1903416","count":1},{"id":"GO:0061454","count":1},{"id":"GO:0007033","count":1}]},{"hash":"2236829327329026053","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006006","count":2},{"id":"GO:0009089","count":2},{"id":"GO:0008615","count":2},{"id":"GO:0035606","count":2}]},{"hash":"1887127419334314484","title":"Mitosis and DNA Repair","description":"The top GO terms are dominated by mitotic processes (spindle assembly, negative regulation of sister chromatid cohesion) and transcription-coupled nucleotide-excision repair, suggesting the cluster mainly groups proteins involved in chromosome maintenance and DNA damage response. A few other terms (light perception, immune signaling) appear as lower-frequency outliers, but they do not define the main theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904908","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0006283","count":2},{"id":"GO:0009584","count":1},{"id":"GO:0036006","count":1}]},{"hash":"11684937562178288","title":"Transmembrane Transport of Nutrients and Ions","description":"The GO terms cluster around diverse transmembrane transport activities (sugars, vitamins, sialic acid, xenobiotics, nitrate/nitrite, sodium) and vesicle-related neurotransmitter loading, suggesting a group of membrane transport proteins with broad substrate specificity rather than a single, narrow function.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":2},{"id":"GO:0015757","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2}]},{"hash":"1286174462777672655","title":"Antibiotic and flavonoid biosynthesis cluster","description":"The top GO terms show strong signals for biosynthesis of antibiotics and a variety of flavonoid glycosides (anthocyanin, cyanidin glucoside, quercetin glucoside), plus related glycosylation and cell envelope processes (lipoteichoic acid biosynthesis, cell wall organization). This suggests a theme of secondary metabolite production spanning both bacterial cell-wall\u2013associated pathways and plant flavonoid biosynthesis, possibly reflecting shared glycosylation or transferase activities. Confidence: Medium","confidence":"","size":7,"edges":5,"triangles":1,"max_degree":4,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0009718","count":5},{"id":"GO:0033485","count":3},{"id":"GO:0052697","count":3},{"id":"GO:0030259","count":3}]},{"hash":"268684576096667082","title":"Unknown","description":"The GO terms are a scattered mix of developmental (lung development) and a broad set of metabolic biosynthesis and catabolic processes (steroid, estrogen, androgen, retinal, fatty acid elongation, BH4, PHB, etc.), with no clear, single functional theme tying all proteins together. This makes it hard to assign a precise, representative label beyond a general \u201cdiverse metabolism/development\u201d flavor, so I\u2019m marking it Unknown with no confidence.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030324","count":5},{"id":"GO:0045150","count":5},{"id":"GO:0042619","count":5},{"id":"GO:0006729","count":5},{"id":"GO:0006703","count":5}]},{"hash":"1785834465214291205","title":"Translation initiation control and protein turnover","description":"This cluster is dominated by GO terms related to initiating translation, forming the preinitiation complex, and IRES-dependent viral initiation, pointing to a core theme of regulating protein synthesis. The presence of ubiquitin-dependent protein catabolic processes and deneddylation further ties these proteins to post-translational modification and protein turnover, suggesting a coordinated role in balancing synthesis and degradation. A few terms like mitotic cytokinesis and germ-line cyst encapsulation may reflect multifunctionality or annotation breadth, but the primary signal is translational control coupled with ubiquitin-mediated turnover.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000281","count":2},{"id":"GO:0000338","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0075522","count":2}]},{"hash":"427792746859979227","title":"Neuronal development and synaptic signaling","description":"These proteins show enrichment for GO terms related to neural development and synaptic function: neuromuscular junction development, branching morphogenesis of a nerve, NMDA receptor clustering, and anterograde synaptic vesicle transport. Calcium signaling is reflected by activation of store-operated calcium channels, and membrane lipid metabolism is indicated by ceramide phosphoethanolamine biosynthesis, which can influence membrane dynamics in neurons. While apoptotic and DNA damage response terms appear, they are less representative of the cluster's main theme; they may reflect cellular stress contexts or shared components. Overall, the set seems to cluster around neuronal development and synaptic signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0006310","count":2},{"id":"GO:1905373","count":1},{"id":"GO:0032237","count":1},{"id":"GO:0097114","count":1}]},{"hash":"961429641561987723","title":"Organogenesis and ECM biosynthesis","description":"The cluster shows enrichment for organ development terms (pharyngeal system development, kidney development, mammary gland epithelial cell differentiation, neural plate axis specification) and extracellular matrix-related biosynthesis (cell wall organization, heparan sulfate proteoglycan biosynthetic process). A few lipid metabolism terms are present but less central, suggesting the dominant theme is organogenesis tied to ECM production. Medium","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060037","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0071555","count":2},{"id":"GO:0015012","count":2},{"id":"GO:0018996","count":1}]},{"hash":"1057555732092558356","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0046597","count":6},{"id":"GO:0070534","count":6},{"id":"GO:0043123","count":6},{"id":"GO:0031664","count":6},{"id":"GO:0032897","count":6}]},{"hash":"943377686713900725","title":"DNA Damage Response and Checkpoint Signaling","description":"The cluster is enriched for GO terms related to DNA repair, DNA damage response, replication and meiotic checkpoint signaling, and cellular response to ionizing radiation, indicating a cohesive theme around nuclear DNA maintenance and damage signaling. A couple of outlier terms (zinc transport, serine biosynthesis) are present but do not override the core DNA damage\u2013related functions.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:1902231","count":1},{"id":"GO:0051598","count":1},{"id":"GO:0071479","count":1},{"id":"GO:0006281","count":1}]},{"hash":"752798273736628445","title":"Immune signaling and inflammatory regulation","description":"Most terms cluster around immune/inflammatory regulation (NOD1 signaling, IL-12 suppression, macrophage cytokine production, prostaglandin biosynthesis, osteoclast differentiation), with a note on glycosylation and MAPK/JNK regulation. Together they suggest a group of proteins involved in modulating immune responses and inflammation rather than a single enzymatic pathway.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035269","count":1},{"id":"GO:0060049","count":1},{"id":"GO:0046329","count":1},{"id":"GO:0001516","count":1},{"id":"GO:0045670","count":1}]},{"hash":"1575280257502766580","title":"B cell signaling and phagocytosis","description":"This cluster is enriched for immune signaling terms, notably B cell receptor signaling and Fc receptor\u2013mediated signaling, along with innate immune response and phagocytosis, suggesting a role in adaptive immune activation and phagocytic immune function; ubiquitination and regulatory signaling terms support fine-tuning of these pathways.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0043066","count":2}]},{"hash":"1043252048136441617","title":"ER-Golgi Vesicle Trafficking","description":"The top terms strongly point to vesicle transport between the endoplasmic reticulum and Golgi apparatus, indicating a cluster centered on ER-Golgi trafficking. Supporting terms suggest related regulation (GTPase activity, TORC1 signaling) and even broader processes like mRNA transport, which may reflect coordinated cellular logistics during growth and division.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":2},{"id":"GO:0070262","count":2},{"id":"GO:0038202","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006888","count":2}]},{"hash":"580275417481545740","title":"Unknown","description":"The top terms span transcription termination, RNA Pol II regulation, translational control, responses to a drug, vascular and Schwann cell development, mitotic ring assembly, DNA replication, fungal ascospore formation, and repeat maintenance. This broad mix shows no cohesive, single function linking the proteins, suggesting the cluster does not share a common GO-driven role.","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070940","count":6},{"id":"GO:0030847","count":6},{"id":"GO:0036496","count":6},{"id":"GO:0042220","count":6},{"id":"GO:0001569","count":6}]},{"hash":"2177207114843105513","title":"DNA Damage Response and Ubiquitination","description":"The GO terms cluster around DNA repair (NER and postreplication repair), cell cycle control (G2/M transition), and regulation by protein modifications (K63/K6 ubiquitination and neddylation), indicating a cohesive theme of DNA damage response and its regulation by ubiquitin-like pathways. Some terms (e.g., viral process, BMP signaling) appear less central but may reflect broader regulatory interactions.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016562","count":6},{"id":"GO:0016032","count":6},{"id":"GO:0070911","count":6},{"id":"GO:0030509","count":6},{"id":"GO:0042275","count":6}]},{"hash":"1486188330410023217","title":"DNA Repair and Ubiquitin/Neddylation Signaling","description":"The cluster centers on DNA repair pathways (nucleotide-excision repair, error-free postreplication repair) and cell-cycle control (G2/M transition), with heavy enrichment for ubiquitin- and neddylation-related modifications (K63- and K6-linked ubiquitination). This suggests a DNA damage response network regulated by ubiquitin-like signaling. Some terms (viral process, BMP signaling) are less directly connected but may reflect broader regulatory crosstalk.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016562","count":6},{"id":"GO:0016032","count":6},{"id":"GO:0070911","count":6},{"id":"GO:0030509","count":6},{"id":"GO:0042275","count":6}]},{"hash":"1382773430313703352","title":"Mammary gland proliferation and mitotic regulation","description":"This cluster centers on core cell-cycle processes (G1/S and G2/M transitions, spindle pole separation, mitotic re-entry) and DNA-templated transcription, paired with mammary gland\u2013specific proliferation and alveolus development terms, suggesting a tissue-specific proliferative program tied to mitosis. Some developmental terms like Leydig differentiation may reflect broader growth signaling context, but the dominant signal is mitotic progression coupled to mammary development.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0010696","count":5},{"id":"GO:0000086","count":5},{"id":"GO:0000082","count":5},{"id":"GO:0000320","count":5}]},{"hash":"633737905608235595","title":"Purine Nucleotide Biosynthesis & Salvage","description":"The dominant GO terms are nucleoside monophosphate phosphorylation, ADP/CDP biosynthesis, AMP salvage, and purine ribonucleotide interconversion, indicating a cluster focused on purine nucleotide metabolism and recycling. The brain and liver development terms likely reflect broader gene functions or annotations but do not override the nucleotide metabolism signal.","confidence":"Medium","size":6,"edges":8,"triangles":4,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046940","count":5},{"id":"GO:0046939","count":5},{"id":"GO:0046041","count":4},{"id":"GO:0006172","count":4},{"id":"GO:0046705","count":4}]},{"hash":"737167298343185333","title":"Retinal Neuropeptide Signaling and Pain Perception","description":"The proteins cluster around neural sensory signaling, highlighted by neuropeptide signaling, sensory perception of pain, visual perception, and photoreceptor cell maintenance. This suggests a shared function in retinal/visual sensory pathways and pain modulation via neuropeptides, with some ancillary regulation of cholinergic signaling and inflammatory mediators.","confidence":"Medium","size":6,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0051930","count":2},{"id":"GO:0090198","count":2}]},{"hash":"836558135110031602","title":"Wnt-regulated dorsal ectoderm patterning","description":"These proteins are enriched for embryonic-development terms, especially negative regulation of canonical Wnt signaling, ectoderm development, and dorsal identity determination, along with cell migration and anisotropic growth. Despite some miscellaneous terms (viral process, ER calcium), the dominant theme is Wnt-driven patterning and morphogenesis in the ectoderm. ","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0090090","count":4},{"id":"GO:0043065","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0016032","count":3}]},{"hash":"1636065990810328823","title":"Ubiquitin-mediated regulation of transcription and chromatin in development","description":"Based on the top terms, these proteins are linked by ubiquitin-dependent protein turnover (including autoubiquitination and K63-linked ubiquitination) and by chromatin-related marks (histone methylation), together with transcriptional regulation and developmental processes such as placental morphogenesis and vasculogenesis. This points to a cohesive role in controlling gene expression via ubiquitin signaling and chromatin modification during development, rather than a single isolated pathway.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046328","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0060669","count":3},{"id":"GO:0097198","count":2}]},{"hash":"938891602289014327","title":"Unknown","description":"The GO terms show a mix of insulin response, oxidative detoxification, several obsolete amino acid biosynthetic/catabolic processes, fruit ripening, and sphingomyelin biosynthesis, suggesting annotation noise and no clear, single shared function among the proteins. ","confidence":"","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032869","count":5},{"id":"GO:0098869","count":3},{"id":"GO:0033362","count":3},{"id":"GO:0009835","count":3},{"id":"GO:0019518","count":3}]},{"hash":"785687566533589387","title":"Cardiac development transcriptional regulation","description":"This cluster is anchored by DNA-templated transcription and by heart-specific development terms such as dorsal vessel heart proper cell fate commitment and ventricular cardiac muscle tissue morphogenesis, suggesting a role in transcriptional control during heart development. The presence of related signaling and ECM terms (negative regulation of NF-kappaB signaling, negative regulation of collagen biosynthesis) and protein heterooligomerization supports a broader context of regulatory complexes and pathways involved in developmental morphogenesis and tissue remodeling. Overall, the functions point to transcriptional regulation guiding cardiac development.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0043124","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0032966","count":2}]},{"hash":"1883229820598455254","title":"Meiosis-associated chromosome movement and actin remodeling","description":"The top GO terms point to meiotic chromosome movement toward the spindle pole and DNA recombination, complemented by robust signals for actin cytoskeleton remodeling (Arp2/3-mediated nucleation and cortical patch assembly). This suggests a coherent cluster of proteins coordinating chromosome dynamics in meiosis with cytoskeletal remodeling and related processes such as organelle inheritance, making this a focused meiosis/cytoskeleton group. ","confidence":"Medium","size":6,"edges":12,"triangles":10,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032508","count":5},{"id":"GO:0006310","count":3},{"id":"GO:0016344","count":2},{"id":"GO:0010628","count":2},{"id":"GO:0000147","count":2}]},{"hash":"186832890197959215","title":"Neuroimmune Pain Signaling","description":"Based on the GO terms, the cluster centers on neural signaling (neuropeptide signaling, acetylcholine regulation) intertwined with immune/inflammatory responses (immune response, cytokine/chemokine production) and pain perception (sensory pain and its regulation). While a couple terms like bone remodeling and blood pressure are less central, the core theme ties neural signaling to immune modulation and pain.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006955","count":2},{"id":"GO:0007218","count":2},{"id":"GO:0046849","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0051930","count":1}]},{"hash":"1140093766658708838","title":"Nutrient and Ion Transporters","description":"Based on the GO terms, most entries are involved in transmembrane transport of diverse substrates: sodium export, pantothenate, biotin, glucose, and myo-inositol transport, with an additional note on acetylcholine biosynthesis. This dominant theme points to a cluster of membrane transport proteins specialized for nutrient and ion movement across cellular boundaries. The other terms (neural development and photoreceptor maintenance) are weaker associations and likely reflect broader roles of included proteins rather than a shared function of the cluster.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071436","count":1},{"id":"GO:0015887","count":1},{"id":"GO:0015878","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0015798","count":1}]},{"hash":"149354635766962519","title":"Ubiquitin-Dependent Proteolysis and Translation Initiation","description":"The GO terms indicate strong involvement in ubiquitin-mediated protein degradation (ERAD, autoubiquitination, histone ubiquitination) and in translation initiation (preinitiation complex formation and translation reinitiation). Additional terms point to apoptosis regulation and TNF signaling, suggesting the cluster centers on regulated protein turnover and its links to cell fate and antiviral responses.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0070535","count":2},{"id":"GO:0033209","count":2}]},{"hash":"1564896307896942767","title":"Synaptic actin remodeling and plasticity","description":"This cluster centers on actin cytoskeleton regulation (actin crosslink formation, barbed-end capping) and signaling via GTPases/Ras, together with NMDA receptor clustering and long-term potentiation, suggesting roles in synaptic remodeling and plasticity rather than a single non-neuronal process. Some terms like heart development or osteoclast fusion are peripheral, but the dominant theme is neuronal actin-driven synaptic modulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060368","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0060291","count":2}]},{"hash":"1561732082811872784","title":"TLR-Mediated Innate Immune Signaling","description":"The GO terms are dominated by toll-like receptor pathways (TLR4, TLR5) and MyD88-dependent signaling with responses to lipopolysaccharide, indicating a cluster centered on TLR-driven innate immune signaling. A few terms (CAMKK-AMPK regulation, JAK-STAT modulation, chromatin localization) are peripheral and do not obscure the core theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905289","count":1},{"id":"GO:0002755","count":1},{"id":"GO:0019800","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0046426","count":1}]},{"hash":"1831072408856988539","title":"Transcription elongation regulation (RNAP I/II)","description":"The cluster\u2019s top GO terms are dominated by transcription elongation and its regulation, including DNA-templated transcription elongation, antitermination, and regulation of elongation by RNA polymerase I and II, with termination also represented. While a couple of terms touch on rRNA processing or translational elongation, the core signal points to elongation control during transcription, spanning both RNAP I and II.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006354","count":1},{"id":"GO:0031564","count":1},{"id":"GO:2001208","count":1},{"id":"GO:2001209","count":1},{"id":"GO:0006414","count":1}]},{"hash":"1333645098816694227","title":"Brain development with radial glial scaffolding","description":"This cluster is dominated by GO terms tied to neural development, especially brain development and forebrain radial glial differentiation, as well as formation of radial glial scaffolds and negative regulation of neuron apoptosis. Although there are also terms related to cochlea and liver development, the strongest and most recurrent signals point to neural development and structural organization in the brain via radial glial scaffolding.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043524","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0021943","count":4},{"id":"GO:0021861","count":4},{"id":"GO:0090103","count":4}]},{"hash":"2280937975629891969","title":"DNA Repair and Replication","description":"The top GO terms are dominated by genome maintenance processes such as single-strand break repair, UV-damage excision repair, and DNA replication, suggesting these proteins cluster around DNA damage response and replication functions. While other terms appear (e.g., ubiquitination, cytokinesis, neuronal differentiation), the strongest signal centers on DNA repair and replication pathways, justifying a label focused on genome integrity maintenance.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000012","count":1},{"id":"GO:1990966","count":1},{"id":"GO:0070940","count":1},{"id":"GO:0046902","count":1},{"id":"GO:2000620","count":1}]},{"hash":"888470778421151251","title":"RNA splicing and mRNA processing regulation","description":"This cluster centers on spliceosome-mediated mRNA splicing (cis and alternative) with both positive and negative regulation, plus related post-transcriptional processes such as mRNA stability under stress, translation reinitiation, and mRNA modification, indicating a set of proteins involved in RNA processing and post-transcriptional regulation under stress.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0048025","count":2},{"id":"GO:1901407","count":2}]},{"hash":"353837467396839441","title":"NOD/NF-kappaB Innate Immune Signaling Regulators","description":"The GO terms cluster around NOD1/NOD2 signaling and regulation of NF-kappaB activity, with downstream immune effects like IL-12 production, dendritic cell differentiation, and macrophage chemokine production, suggesting a cohesive set of innate immune signaling regulators. Some peripheral terms (heat response, salicylic acid signaling) are less central but do not outweigh the core theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0045083","count":1},{"id":"GO:0070427","count":1},{"id":"GO:2000171","count":1}]},{"hash":"532011846421361900","title":"Endocytic Trafficking to Vacuole via MVB","description":"The cluster centers on endocytosis and vesicle trafficking between the Golgi, early/late endosomes, and vacuoles, as shown by GO terms for endocytosis, Golgi\u2013endosome transport, and multivesicular body sorting, with actin patch assembly supporting uptake and insect-specific storage protein import into the fat body, all pointing to a cohesive endocytic/trafficking program. ","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007565","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0006623","count":2},{"id":"GO:0000147","count":2}]},{"hash":"1172114720754904119","title":"NF-kB-mediated inflammation and coagulation","description":"The top GO terms point to immune/inflammatory signaling (canonical NF-kappaB activation, inflammatory response) and coagulation (blood coagulation, fibrin clot formation) with an immune-organ context (spleen development). Some terms appear incidental or misannotated (e.g., hemoglobin metabolism, salivary gland development), but the core theme is inflammation linked to coagulation. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0018153","count":1},{"id":"GO:0020027","count":1},{"id":"GO:0051482","count":1}]},{"hash":"1119126302434324617","title":"Protein quality control and translation regulation","description":"Contains GO terms for nucleotide-excision repair, ubiquitin-dependent ERAD, autoubiquitination, proteasomal protein degradation, translation and translational initiation, and signaling pathways (TNF/JNK and insulin). This pattern suggests a theme of proteostasis, where protein turnover via the ubiquitin-proteasome system and ER-associated degradation interfaces with translation control and stress signaling. Thus, the cluster is best described as protein quality control with emphasis on degradation and translation regulation.","confidence":"Medium","size":6,"edges":10,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070911","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0006412","count":2}]},{"hash":"1545686684299374831","title":"ECM remodeling and cell adhesion","description":"This cluster centers on extracellular matrix dynamics and adhesion processes, highlighted by terms for metallopeptidase regulation, hyaluronan metabolism, ECM assembly regulation, cell-cell adhesion, extravasation, coagulation, and complement activation. Together they point to ECM remodeling during tissue repair and inflammatory responses, with adhesion and immune/coagulation components as supporting themes. Some terms (e.g., dendrite regeneration, endodermal differentiation) may reflect broader developmental contexts where ECM and cell interactions are involved, but the dominant signal is ECM remodeling and related adhesion/inflammation. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045123","count":2},{"id":"GO:1905050","count":2},{"id":"GO:0034113","count":2},{"id":"GO:0031104","count":2},{"id":"GO:0007596","count":2}]},{"hash":"1842245432165921968","title":"Proteostasis via ubiquitin-proteasome and autophagy","description":"The GO terms cluster around ubiquitin-dependent protein degradation (autoubiquitination, ERAD, proteasomal catabolic regulation) and autophagy (aggrephagy), pointing to protein quality control and turnover as the core theme; other terms about transcription regulation and GPCR internalization likely reflect broader cellular stress responses attached to these proteostasis processes.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006357","count":6},{"id":"GO:0070911","count":6},{"id":"GO:1904021","count":6},{"id":"GO:0000753","count":6},{"id":"GO:0035973","count":6}]},{"hash":"602296542686709873","title":"Retinoid Metabolism and Embryogenesis","description":"This cluster is anchored by GO terms for retinal and retinol metabolism, pointing to retinoid (vitamin A) pathways, while also including embryonic development terms such as face development, proximal/distal pattern formation, and embryonic digestive tract development. Together, these terms suggest a theme where retinoid metabolism/signaling influences embryogenesis and tissue patterning, with other metabolic terms providing general metabolic context rather than conflicting the central link.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":6},{"id":"GO:0042572","count":6},{"id":"GO:0060324","count":5},{"id":"GO:0055129","count":5},{"id":"GO:0015976","count":5}]},{"hash":"1343179923146246522","title":"Ubiquitin/SUMO Proteostasis","description":"The top terms cluster around protein modification and degradation: protein sumoylation, ubiquitin-dependent ERAD, and autoubiquitination, plus aggrephagy. These point to a common theme of protein quality control and turnover. Other terms (transcription regulation, GPCR internalization, spindle pole body duplication, mitochondrial fusion) suggest broader cellular maintenance, but the strongest signal is ubiquitin/SUMO\u2013mediated proteostasis. ","confidence":"Medium","size":6,"edges":10,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":4},{"id":"GO:0006357","count":3},{"id":"GO:1904021","count":3},{"id":"GO:0000753","count":3},{"id":"GO:0035973","count":3}]},{"hash":"244798680576574780","title":"Immune regulation and inflammatory signaling","description":"The cluster is enriched for immune-related regulation terms, including negative regulation of IL-12 production, positive regulation of MIP-1 alpha production, and NOD1 signaling, plus activities like follicular dendritic cell differentiation and regulation of salicylic acid signaling. While there are some stress or development terms (response to heat, dendrite/heart morphogenesis), the overall pattern points to modulation of immune and inflammatory signaling rather than a single metabolic pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045083","count":3},{"id":"GO:0031954","count":3},{"id":"GO:2000171","count":3},{"id":"GO:0071642","count":3},{"id":"GO:0070427","count":3}]},{"hash":"146082047094242063","title":"Integrin signaling and telomere maintenance","description":"The top terms center on cell signaling pathways (integrin-mediated signaling, ephrin receptor signaling, GPCR-associated signaling, and regulation of synapse assembly) and, separately, on telomere maintenance regulation and ADP-ribosylation. This suggests proteins involved in signaling processes linked to cellular growth and connectivity, plus components affecting chromosome end maintenance, hence a combined label reflecting both themes. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0001558","count":3},{"id":"GO:0051965","count":3},{"id":"GO:1904908","count":2},{"id":"GO:0070212","count":2}]},{"hash":"110946485642844559","title":"Retroviral replication and proviral latency","description":"This cluster centers on retroviral processes: entry into host cells, integration of viral DNA, reverse transcription (RNA-templated DNA synthesis), and establishment of proviral latency, with associated DNA replication/recombination activities. The GO terms collectively point to stages of the viral life cycle and proviral maintenance, rather than purely host processes.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0015074","count":1}]},{"hash":"417087908950652853","title":"Unknown","description":"The cluster only has two GO terms represented (ribosome biogenesis and activation of protein kinase activity) with a single hit each, which point to distinct processes (ribosome assembly vs. kinase signaling) and do not reveal a cohesive functional theme across all five proteins. Therefore, a single representative label is not evident from the data. ","confidence":"","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0032147","count":1}]},{"hash":"310456311780667521","title":"Innate immune signaling and inflammatory regulation","description":"This cluster centers on GO terms related to innate immune pathways (NOD1 signaling, regulation of IL-12 and macrophage chemokine production) and dendritic cell differentiation, suggesting a cohesive theme of immune signaling and inflammation regulation, with a few cell-cycle or stress-related terms likely reflecting broader regulatory roles.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":2},{"id":"GO:0045083","count":1},{"id":"GO:0070427","count":1},{"id":"GO:2000171","count":1},{"id":"GO:0071642","count":1}]},{"hash":"398595515796817165","title":"Mesoderm formation and kidney morphogenesis","description":"The top GO terms cluster around early embryonic development, especially mesoderm formation, gastrulation, mesodermal cell fate commitment, and kidney morphogenesis (metanephric mesenchyme morphogenesis and ureteric bud development). A couple of additional terms seem peripheral or more general (synapse maturation, ubiquitin regulation), but the dominant theme ties to mesoderm and kidney organogenesis, suggesting these proteins function in these developmental processes.","confidence":"High","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001702","count":3},{"id":"GO:1901522","count":2},{"id":"GO:0001707","count":2},{"id":"GO:0072133","count":2},{"id":"GO:0060074","count":2}]},{"hash":"157571199815011047","title":"Skin thermosensation and tactile-pain signaling","description":"The top GO terms cluster around temperature sensing (diet-induced thermogenesis, cellular response to temperature), pain perception, and touch detection, which are key aspects of skin sensory physiology. Additional terms on calcium signaling, cell-matrix adhesion, and skin development support the broader signaling and structural context of sensory and inflammatory pathways in skin. Therefore, this cluster is best described as skin thermosensation and tactile-pain signaling.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0034767","count":3},{"id":"GO:0071642","count":3}]},{"hash":"59403825741340725","title":"DNA Damage Response and Cell Cycle Ubiquitination","description":"This cluster centers on DNA repair processes (global genome nucleotide-excision repair; error-free postreplication repair) and cell cycle control (G2/M transition), with notable involvement of protein modification pathways such as K63- and K6-linked ubiquitination and neddylation, which are key for signaling and protein turnover during DDR and cell cycle progression. While a few terms like BMP signaling, peroxisome import, and viral process are present, the dominant theme across the terms is DNA damage response coupled with ubiquitin-like modification influencing cell cycle events, supporting the chosen label.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016562","count":5},{"id":"GO:0016032","count":5},{"id":"GO:0070911","count":5},{"id":"GO:0030509","count":5},{"id":"GO:0042275","count":5}]},{"hash":"962307138548716814","title":"Redox Homeostasis and Antioxidant Metabolism","description":"The cluster centers on redox balance and antioxidant defenses, with multiple terms for oxidant detoxification, redox homeostasis, and ascorbate (vitamin C) metabolism/response. Supporting terms about DNA damage response (p53 signaling) and modulation of signaling pathways (ERK, EGFR) fit a broader stress-response/detox theme, including xenobiotic catabolism. The germ cell proliferation term is less central to the core redox/detox theme.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2000255","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0019852","count":3},{"id":"GO:0043517","count":3}]},{"hash":"723289471981840435","title":"RNA processing and chromatin remodeling","description":"The cluster centers on gene-expression regulation across RNA processing (splicing, ncRNA-mediated silencing, mRNP assembly) and chromatin dynamics (chromatin remodeling, histone modification, DNA topology), suggesting a module coordinating RNA maturation with chromatin state to control transcription and RNA processing.","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0090394","count":4},{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:2000616","count":2},{"id":"GO:1990120","count":2}]},{"hash":"631149422609901626","title":"Epigenetic Regulation of Gene Expression","description":"The cluster is driven by chromatin-modifying processes (histone deacetylation and H3K4 methylation) and imprinting-related regulation of gene expression, pointing to epigenetic control of transcription as the core shared function, with developmental and proliferation terms providing contextual relevance.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006349","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0034316","count":2},{"id":"GO:0016575","count":2},{"id":"GO:0008283","count":2}]},{"hash":"939979458358842373","title":"Unknown","description":"This set mixes neural development (midbrain dopaminergic neuron differentiation, axon guidance), intracellular trafficking (endosome to lysosome transport, vacuole fusion) and diverse processes (cell wall biosynthesis regulation, angiogenesis-related migration), with no clear, shared function tying all terms.","confidence":"","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090334","count":4},{"id":"GO:1904948","count":4},{"id":"GO:1905289","count":3},{"id":"GO:0032889","count":3},{"id":"GO:0048532","count":3}]},{"hash":"823988107826159848","title":"Neuronal axon guidance and synapse organization","description":"Driven by terms like motor neuron axon guidance, protein localization to synapse, receptor clustering, and cell-matrix adhesion, the cluster appears to center on neuronal development and synapse organization. Additional terms (Wnt signaling regulation, transcription, and metabolism) are more general but do not override the neuronal theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0097350","count":2},{"id":"GO:0035418","count":2}]},{"hash":"715417470191270946","title":"Unknown","description":"The terms cover unrelated processes from metabolism (glycogen catabolic, aerobic respiration, polyamine biosynthesis) to RNA modification (rRNA, tRNA wobble) and various responses (interleukin-1, cocaine) and nodulation, with no shared pathway or interaction evident (no edges/triangles). This makes a cohesive functional label unlikely.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005980","count":2},{"id":"GO:0000154","count":1},{"id":"GO:0002098","count":1},{"id":"GO:0000056","count":1},{"id":"GO:0006596","count":1}]},{"hash":"522049459658693154","title":"Embryonic vascular and neural crest development","description":"The terms cluster around embryonic development, especially vascular/angiogenic processes (angiogenesis, endothelial cell chemotaxis, negative regulation of endothelial chemotaxis, sprouting angiogenesis regulation) and neural crest/mesoderm patterning (paraxial mesoderm development, cardiac neural crest cell development, axon guidance). Although there are also stress/immune-related terms, the dominant theme ties to vascular and neural crest\u2013driven morphogenesis in development. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":1},{"id":"GO:0006950","count":1},{"id":"GO:0032687","count":1},{"id":"GO:2000546","count":1},{"id":"GO:0007411","count":1}]},{"hash":"1314177662862526125","title":"Spliceosome-driven mRNA processing and regulation","description":"The GO terms cluster around post-transcriptional control, especially regulation and processing of mRNA via the spliceosome (including alternative splicing, and spliceosome-mediated regulation), along with related mRNA stability, translation reinitiation, and modification processes, pointing to a cohesive function in RNA maturation and expression control.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0048025","count":3},{"id":"GO:1901407","count":3}]},{"hash":"360022730249544493","title":"ER Stress and Protein Folding","description":"This cluster is enriched for endoplasmic reticulum\u2013related proteostasis functions: protein folding in the ER, ER stress\u2013driven translation initiation changes, and ER-associated degradation. The inclusion of redox homeostasis and heat response terms supports a shared cellular stress-response theme. Some developmental terms (mesoderm formation, hedgehog/SMO signaling) may reflect broader signaling roles, but the dominant pattern points to ER proteostasis as the core function.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":5},{"id":"GO:1901621","count":4},{"id":"GO:0001707","count":4},{"id":"GO:0036494","count":4},{"id":"GO:0045454","count":4}]},{"hash":"260302360566912534","title":"Multisensory chemical and pH/ion sensing","description":"The GO terms point to multiple sensory modalities, including sour taste, salt aversion, chemical stimulus detection related to pain, pH/acidic responses, and ion balance, with a touch of mechanosensory signaling. This pattern suggests proteins involved broadly in detecting and transducing chemical, pH, and ionic cues across senses, rather than a single highly specific pathway.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050915","count":1},{"id":"GO:0035199","count":1},{"id":"GO:1905792","count":1},{"id":"GO:0071467","count":1},{"id":"GO:0050966","count":1}]},{"hash":"1861261956747511933","title":"Ubiquitin-Dependent Protein Degradation","description":"This cluster is best characterized by terms related to ubiquitination and ubiquitin-mediated protein catabolic processes (poly- and monoubiquitination, ubiquitin-dependent protein degradation, and ERAD). While a few terms touch on transcription or other pathways, the dominant signal points to ubiquitin signaling and proteolysis as the shared function of these proteins.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2196551143169471544","title":"Neurotransmitter Transport and Glycinergic Signaling","description":"Top GO terms indicate roles in neurotransmission and amino acid transport, notably glycinergic synaptic activity (glycine import, secretion, and glycinergic transmission), along with serotonin-related processes and dopamine catabolism. This points to a cluster of proteins involved in neuronal signaling and amino acid transport rather than metabolic enzymes. Therefore, the label Neurotransmitter Transport and Glycinergic Signaling reflects the dominant theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905847","count":1},{"id":"GO:0051610","count":1},{"id":"GO:0061537","count":1},{"id":"GO:0042420","count":1},{"id":"GO:0036233","count":1}]},{"hash":"1270406445302828388","title":"Ubiquitination-regulated antiviral innate signaling","description":"The cluster centers on ubiquitination-related terms (protein ubiquitination and autoubiquitination) and regulation of RIG-I signaling, pointing to modulation of innate antiviral responses. Adaptive immune response is also represented, with additional terms like Wnt signaling and cell cycle suggesting some pleiotropy, but the strongest cohesive theme is ubiquitination-driven control of antiviral signaling pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0002250","count":1},{"id":"GO:0039536","count":1},{"id":"GO:0016567","count":1}]},{"hash":"500920310638486632","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":5},{"id":"GO:0042759","count":5},{"id":"GO:0048579","count":5},{"id":"GO:2000196","count":5},{"id":"GO:0048577","count":5}]},{"hash":"1369234812429842420","title":"Immune signaling and dense core granule maturation","description":"These proteins show strong representation of innate/adaptive immune signaling terms (positive regulation of TLR3 signaling, negative regulation of interferon and IL-4 pathways) together with granule biology (dense core granule maturation, granzyme B production). The combination suggests a theme where immune signaling pathways couple to secretory granule maturation and cytotoxic functions, with additional links to protein tyrosine kinase regulation and ER-associated stress responses (IRE1-mediated UPR). ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034141","count":4},{"id":"GO:1990502","count":3},{"id":"GO:1902215","count":3},{"id":"GO:0032687","count":3},{"id":"GO:0060336","count":3}]},{"hash":"1824875742409798987","title":"Unknown","description":"The GO terms are scattered across diverse biological areas (viral process, epithelial polarity, metabolism, cardiac depolarization, DNA repair, behavior), with only a couple relating to nervous system function, and no clear unifying pathway or function. The topology is minimal (one edge), suggesting weak or incidental connections, so there is no coherent theme to name beyond Unknown.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":1},{"id":"GO:0090162","count":1},{"id":"GO:0006015","count":1},{"id":"GO:0098912","count":1},{"id":"GO:0016311","count":1}]},{"hash":"586551002985104352","title":"Chromatin organization and nucleosome assembly","description":"GO terms indicate heterochromatin organization, nucleosome assembly, and chromatin localization, with additional histone modification signals (H3-K27 and H3-K4 methylation). This points to a cohesive role in chromatin architecture and nucleosome dynamics, justifying the label. ","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070828","count":4},{"id":"GO:0006334","count":4},{"id":"GO:0098532","count":4},{"id":"GO:0097298","count":4},{"id":"GO:0016584","count":4}]},{"hash":"2300424725547961909","title":"Neural-endosomal-lysosomal trafficking","description":"The top GO terms point to endosome-to-lysosome pathways, lysosomal protein localization, and vacuolar protein catabolism, with supporting neural/immune contexts (microglia development, paraneural junctions, visual perception, dendritic cell regulation). This suggests a cluster centered on intracellular trafficking through endosomal and lysosomal compartments in neural and immune cells, including related pigmentation transport (melanosome) and neural junction biology.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0014005","count":2},{"id":"GO:0035646","count":2},{"id":"GO:0030913","count":2},{"id":"GO:1900746","count":2},{"id":"GO:2000145","count":2}]},{"hash":"2021010904614451817","title":"Neural development: axon guidance and myelination","description":"The GO terms are dominated by neural development features: neuron migration, axon guidance, and myelination, with supporting signals such as Hedgehog (Smoothened) signaling and processes guiding neural progenitors. A couple of terms relate to endothelial chemotaxis, which can reflect neurovascular interactions, but the core pattern points to axon pathfinding and neuronal maturation rather than vascular processes. Therefore, a neural development-centric label fits best.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032687","count":1},{"id":"GO:0019226","count":1},{"id":"GO:0038033","count":1},{"id":"GO:2000546","count":1},{"id":"GO:0001764","count":1}]},{"hash":"898551977422447479","title":"ER Proteostasis and Stress Response","description":"The top GO terms cluster around endoplasmic reticulum proteostasis and stress responses: protein folding in the ER, ER-associated degradation (ERAD), translation initiation regulation in response to ER stress, heat response, and redox homeostasis. These point to a cohesive theme of ER quality control and cellular stress adaptation. A few terms related to development (cell differentiation, mesoderm formation) appear but are not central to the main proteostasis-focused signal. Overall, the dominant theme is ER proteostasis and stress response.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030154","count":2},{"id":"GO:1901621","count":1},{"id":"GO:0001707","count":1},{"id":"GO:0036494","count":1},{"id":"GO:0045454","count":1}]},{"hash":"1473746610845268183","title":"Muscle development and protein synthesis","description":"The cluster features core terms for ribosome biogenesis and translational initiation, indicating active protein synthesis, alongside terms related to muscle development such as positive regulation of myoblast fusion and regulation of cardiac muscle cell membrane potential, plus mitochondrial fusion and other cellular remodeling processes. This suggests a theme around muscle differentiation coupled with enhanced protein production, hence the chosen label.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:1903833","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0086036","count":1},{"id":"GO:0060988","count":1}]},{"hash":"432896396544413647","title":"Ribosome Biogenesis and Translation","description":"Most terms point to ribosome-related processes: ribosome biogenesis, translation, cytosolic ribosome assembly, and tRNA modification. This suggests the proteins cluster around ribosome production and protein synthesis, with a few unrelated developmental or cellular processes likely reflecting broader annotations or shared cellular roles.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0042256","count":1},{"id":"GO:0001833","count":1},{"id":"GO:0048539","count":1}]},{"hash":"763235704336006906","title":"Ribosome biogenesis and translation","description":"The top GO terms couple strongly to ribosome assembly, biogenesis, and cytoplasmic translation, with SRP-dependent cotranslational targeting to the membrane, pointing to ribosome-related production and protein synthesis. Other terms (phosphorylation/dephosphorylation and DNA repair signaling) are more peripheral, likely reflecting multifunctionality of some proteins. Thus, the core theme is ribosome biogenesis and translation machinery.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006468","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006614","count":1},{"id":"GO:0071353","count":1}]},{"hash":"1326760890794511733","title":"Actin Remodeling in Development and Inflammation","description":"The cluster centers on actin cytoskeleton dynamics, with terms for barbed-end capping and depolymerization, and also includes signals related to development and immune/inflammatory responses (gastrulation, TGF-beta response, cytokine production). This suggests proteins that coordinate actin remodeling with developmental and inflammatory signaling pathways.","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001403","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0031954","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0030042","count":2}]},{"hash":"2191520139810321891","title":"Innate antiviral defense and autophagy-associated proteins","description":"This cluster\u2019s top GO terms emphasize defense response to virus and innate immune response, indicating a primary role in antiviral defense. Additional terms related to lysosome localization and autophagosome maturation suggest the proteins may function within autophagy-lysosome pathways that support innate immunity. Some terms are obsolete or incidental, but the dominant theme ties to innate antiviral responses with autophagy links.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0051092","count":2},{"id":"GO:2000653","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0043278","count":2}]},{"hash":"1554616046282421864","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0002107","count":2},{"id":"GO:0000738","count":2},{"id":"GO:0010606","count":2},{"id":"GO:0006281","count":2}]},{"hash":"1173998499117823636","title":"RNA Pol II Transcription Initiation & Chromatin Regulation","description":"The terms are dominated by RNA polymerase II\u2013driven transcription initiation, preinitiation complex assembly, and transcription regulation, with additional chromatin-related processes such as histone acetylation. This suggests a cohesive cluster of proteins functioning in initiating RNAP II transcription and modulating chromatin state.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0051090","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0007221","count":1},{"id":"GO:0006352","count":1}]},{"hash":"1677728976190789971","title":"Mesodermal development, angiogenesis, and myogenesis","description":"This cluster centers on mesoderm formation, angiogenesis, and myotube differentiation, indicating roles in mesodermal tissue development and muscle/vascular formation. The other terms (stimulus responses, metallopeptidase activity) are supportive or context-dependent rather than defining.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001707","count":5},{"id":"GO:0007118","count":5},{"id":"GO:1905050","count":5},{"id":"GO:0042220","count":5},{"id":"GO:0071375","count":5}]},{"hash":"1755521771278485022","title":"Neural development and signaling","description":"This cluster is dominated by GO terms related to neural signaling and development: nerve impulse transmission, synaptic plasticity, forebrain cell migration, myelination, and Hedgehog/smoothened signaling. Angiogenesis fits within CNS development, and negative regulation of cell migration aligns with migratory processes during brain formation. An outlier term (type IV hypersensitivity) is present but does not override the neural-developmental theme.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":3},{"id":"GO:0044708","count":3},{"id":"GO:0007169","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0048170","count":3}]},{"hash":"1187490399610145821","title":"Neuronal ER stress, ubiquitination, and trafficking","description":"The cluster centers on endoplasmic reticulum quality control and trafficking, highlighted by terms for ER stress-induced apoptotic signaling, ER-to-Golgi transport, and ubiquitination/ERAD pathways. Neural context is suggested by terms related to substantia nigra development and excitatory postsynaptic potential, indicating these stress and protein handling processes are relevant to neuronal signaling. Overall, the proteins likely function in ER-associated protein handling and ubiquitin-regulated trafficking within neurons.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0035690","count":2}]},{"hash":"904442984550442942","title":"Unknown","description":"The top GO terms span insulin regulation, mitochondrial energy production, viral processes, NMDA receptor clustering, embryonic polarity, tyrosine kinase signaling, immune cell migration, receptor internalization, PDGF response, and axon guidance\u2014scattered across diverse biological themes. With no interconnecting edges (Max Degree 0) and only a few proteins, there\u2019s no cohesive function tying the cluster together. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":1},{"id":"GO:0042775","count":1},{"id":"GO:0016032","count":1},{"id":"GO:0097114","count":1},{"id":"GO:0009949","count":1}]},{"hash":"1787597670916280079","title":"Central metabolism and cofactors biosynthesis","description":"The top GO terms span glycolysis and the TCA cycle, plus biosynthesis of heme, thiamine, and quinolinate (NAD biosynthesis) and even capsule polysaccharide and cell wall components. This suggests a cluster centered on core energy production and synthesis of essential cofactors and envelope materials, rather than a single pathway.","confidence":"Medium","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0019805","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0006783","count":2},{"id":"GO:0006782","count":2}]},{"hash":"2030616897109893241","title":"Nucleotide-sugar Polysaccharide Biosynthesis","description":"The top GO terms cluster around the production of sugar nucleotides (e.g., GDP-mannose, UDP-xylose/arabinose/galactose) and the biosynthesis of polysaccharide-containing polymers (colanic acid, polyhydroxybutyrate, sporopollenin). This suggests a cohesive function in generating building blocks for polysaccharide and polymer assembly, even though only a few proteins are in the cluster and some terms are peripheral. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019673","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0033358","count":2},{"id":"GO:0006541","count":2}]},{"hash":"385677229807098522","title":"Steroid and lipid biosynthesis","description":"The cluster shows a strong signal for biosynthetic and metabolic processes, especially those involving steroids and lipids (steroid catabolic and C21-steroid hormone metabolic processes, methyl-branched fatty acid biosynthesis, retinal metabolism, poly-hydroxybutyrate and antibiotic biosynthesis). While a couple terms like lung development are less directly related, the dominant pattern is synthesis and turnover of lipid- and steroid-related compounds, supporting a label around steroid and lipid biosynthesis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0030324","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0045150","count":2},{"id":"GO:0006706","count":2}]},{"hash":"225585940380671977","title":"Valine and proline metabolism with NADPH regeneration","description":"Top GO terms emphasize valine and proline metabolism and NADPH regeneration, pointing to amino acid metabolism with redox cofactor recycling as the main theme. Other terms (glyoxylate, formate, sulfoquinovose catabolism; copper import; sporulation) are more peripheral.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":1},{"id":"GO:1902777","count":1},{"id":"GO:0055129","count":1},{"id":"GO:0042183","count":1},{"id":"GO:0046487","count":1}]},{"hash":"1204752341698946147","title":"Actin Cytoskeleton Remodeling and Rac/JUN Signaling","description":"The top GO terms cluster around actin filament dynamics (capping, bundling, crosslinking, and polymerization-dependent motility) and Rac-mediated signal transduction, with JUN phosphorylation linking to downstream responses. This suggests a coherent theme of actin remodeling driven by Rac signaling and regulated by JUN, despite some peripheral terms.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051016","count":2},{"id":"GO:0007296","count":2},{"id":"GO:0016601","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0007258","count":2}]},{"hash":"1107111607112863993","title":"Neuronal signaling and sensory behavior","description":"The top GO terms cluster around nervous system function: locomotory behavior, sensory perception of sound, GABA signaling, and transmission/innervation, with related behavioral processes like conditioned taste aversion and circadian sleep regulation. While a couple terms mention amyloid-beta and acrosome reaction as broader regulatory processes, the dominant theme is neuronal communication and behavior modulation, so the label captures the cluster's core function.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":5},{"id":"GO:0007605","count":4},{"id":"GO:0007214","count":4},{"id":"GO:0001661","count":4},{"id":"GO:2001023","count":3}]},{"hash":"2089757550502841645","title":"Actin cytoskeleton remodeling and calcium signaling","description":"Based on GO terms focusing on actin patch assembly and Arp2/3 complex\u2013mediated actin nucleation, this cluster appears to center on actin cytoskeleton dynamics. The presence of calcium response terms suggests signaling interplay that modulates cytoskeletal remodeling. While some terms are unrelated or obsolete, the strongest shared function is actin assembly/remodeling and associated downstream signaling, which best explains the protein cluster.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016344","count":2},{"id":"GO:0010628","count":2},{"id":"GO:0000147","count":2},{"id":"GO:0043503","count":2},{"id":"GO:0051592","count":2}]},{"hash":"210778924619013478","title":"GPCR signaling and vesicle trafficking","description":"The GO terms cluster around G protein-coupled receptor (GPCR) signaling pathways (e.g., acetylcholine receptor signaling, adenylate cyclase inhibition) and vesicle dynamics (ER-to-Golgi transport, endosome-to-lysosome transport, calcium-dependent exocytosis), suggesting a functional theme of GPCR-driven signaling linked to vesicle trafficking. Some terms reflect organism-specific processes (ascospore formation, pseudohyphal growth), but the core connection remains GPCR signaling coupled to vesicle transport. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016322","count":2},{"id":"GO:0007213","count":2},{"id":"GO:2000171","count":1},{"id":"GO:1902953","count":1},{"id":"GO:0007193","count":1}]},{"hash":"904518399894483668","title":"Ubiquitin-Dependent Proteolysis and Signaling","description":"The cluster is dominated by ubiquitin-related terms: ubiquitin-dependent protein catabolic process, K63-linked ubiquitination, autoubiquitination, and ERAD-related pathways, indicating a core theme of ubiquitin-mediated proteostasis. The presence of GO terms for regulation of JNK cascade and GTPase activity suggests a link to signaling modulation by ubiquitination, with additional hints of developmental and metabolic regulation. Overall, the strongest, coherent theme centers on ubiquitin-driven degradation and signaling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0070534","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0045723","count":2},{"id":"GO:2000059","count":2}]},{"hash":"1430629609380107469","title":"Synaptic Vesicle Trafficking & Neuromuscular Function","description":"The cluster\u2019s GO terms highlight synaptic vesicle clustering, neuromuscular process controlling posture, and endosome-to-plasma membrane transport, which together point to neuronal membrane trafficking and signaling. Additional terms (bone morphogenesis/mineralization, immune responses, biotic stimulus) are less central to the core theme but may reflect broader roles in development and signaling. Overall, the dominant theme is synaptic/neuronal membrane trafficking with associated neuromuscular function.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060349","count":1},{"id":"GO:0009607","count":1},{"id":"GO:0044381","count":1},{"id":"GO:0050884","count":1},{"id":"GO:0099638","count":1}]},{"hash":"1891984310538087711","title":"Transmembrane Transporters Across Nutrients and Xenobiotics","description":"These four proteins share multiple GO terms centered on transmembrane transport, spanning nitrate assimilation, sodium and phosphate ion transport, galactose and fucose uptake, xenobiotic transport, and even vesicle-related transporter activity. The common thread is membrane transport across a broad range of substrates, suggesting a cluster of diverse transporter proteins rather than a single substrate-specific function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0035461","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0035435","count":2},{"id":"GO:1900754","count":2}]},{"hash":"1122370195499989266","title":"DNA replication and repair machinery","description":"The top GO terms are dominated by DNA replication, DNA repair, mitotic cell cycle, and DNA-templated transcription, indicating proteins involved in genome maintenance and cell division. Although a few peripheral terms touch on development or signaling, the core theme centers on nuclear genome integrity and cell cycle progression, supporting this label.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006281","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0051973","count":4}]},{"hash":"1958043491871666958","title":"Developmental morphogenesis and vesicle trafficking","description":"The top GO terms indicate developmental processes (ossification, kidney development, anatomical structure arrangement, axon guidance, angiogenesis) alongside intracellular trafficking (COPII vesicle budding, endosome-to-lysosome transport, vacuole fusion). This suggests proteins involved in development that rely on vesicular transport and endomembrane system functions, justifying a combined label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0090114","count":3},{"id":"GO:1905289","count":2},{"id":"GO:0032889","count":2}]},{"hash":"932351985875445670","title":"Neuronal signaling and synaptic regulation","description":"This cluster is dominated by terms related to signaling pathways such as GPCR, ephrin receptor, and Wnt signaling, along with regulation of synaptic plasticity and receptor localization to the synapse, pointing to a role in neuronal signaling and synaptic regulation. A few other terms (immune- or cell cycle-related) are low-frequency outliers, but the core theme is neural signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":2},{"id":"GO:1901187","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0045083","count":1}]},{"hash":"493900623404652296","title":"Embryonic Organ Development","description":"The GO terms cluster around embryonic morphogenesis across multiple organs (digestive tract, pancreas, tongue, neural crest, heart) and related signaling (Wnt, TGF-beta) with transcriptional regulation and cell-cycle dynamics, suggesting coordinated organogenesis rather than a single tissue-specific function.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048557","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0031018","count":2},{"id":"GO:0001755","count":2}]},{"hash":"276376149696491071","title":"Unknown","description":"The top GO terms are highly diverse, covering gastric acid regulation, diet-induced thermogenesis, temperature response, pain perception, calcium signaling, ion transport, inflammatory protein production, cardiac action potential regulation, calcium-dependent adhesion, and skin development. There\u2019s no single biological process or cellular function tying these proteins together, making a cohesive label inappropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060453","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0034767","count":2}]},{"hash":"740594470748084335","title":"Drosophila oogenesis mRNA localization and translation control","description":"The top terms point to germline development and precise mRNA handling during oogenesis, especially oskar mRNA localization to the pole plasm and oocyte axis specification, along with RNA processing (splicing, stability) and translation regulation. This suggests a module focused on mRNA localization and translation control in Drosophila germline development.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":2},{"id":"GO:0048485","count":2},{"id":"GO:0042472","count":2},{"id":"GO:0043525","count":2},{"id":"GO:0043524","count":2}]},{"hash":"492485724164528900","title":"Cotranslational membrane targeting and folding","description":"The cluster\u2019s dominant signals are SRP-dependent cotranslational protein targeting to membranes and related post-translational membrane targeting, along with an unfolded protein response, pointing to a core theme of membrane-associated protein biogenesis and chaperone-mediated folding. Some terms (e.g., DNA replication, iron-sulfur cluster assembly) are less connected to this theme, suggesting these proteins broadly participate in general cellular maintenance but the core cluster reflects membrane targeting and folding processes.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":2},{"id":"GO:0034620","count":2},{"id":"GO:0031204","count":2},{"id":"GO:0006616","count":2},{"id":"GO:1902037","count":2}]},{"hash":"347578558052298213","title":"Cardiac GPCR\u2013cAMP signaling","description":"Top GO terms indicate heart-related GPCR signaling (adenylate cyclase activation), blood pressure regulation, and heart development, suggesting a cohesive cluster of cardiac signaling and hormonal pathways. Some outliers (electron transport and pain regulation) exist, but the dominant theme is GPCR-cAMP signaling in cardiac physiology.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0010579","count":2}]},{"hash":"1706528693159455872","title":"Transmembrane transporters for nutrients and ions","description":"Based on the GO terms, the cluster is dominated by transmembrane transport activities for a variety of substrates, including vitamins (vitamin transmembrane transport; 5-formyltetrahydrofolate transport), sugars (D-glucose transmembrane transport), and ions (sodium, phosphate transmembrane transport), as well as xenobiotics. A couple of terms relate to regulation of cell growth and thymic T cell selection, but the prevalent theme points to membrane transport proteins handling small molecules and ions. Confidence is high.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":2},{"id":"GO:0045060","count":2},{"id":"GO:0019852","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0015885","count":1}]},{"hash":"206732840888549498","title":"Unknown","description":"The top terms are scattered across neural development and immune signaling with no clear shared function or interaction pattern to unify the four proteins; several terms are obsolete, and there are no edges connecting the proteins, so no cohesive biological theme emerges. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021552","count":1},{"id":"GO:0044376","count":1},{"id":"GO:1990022","count":1},{"id":"GO:0002244","count":1},{"id":"GO:0014033","count":1}]},{"hash":"1053925669024882709","title":"Amino acid and small solute transporters","description":"Dominant GO terms point to membrane transport of amino acids (arginine, lysine, ornithine, D-serine) and other small solutes (ammonium, GABA), including transepithelial transport and related hypotonic response. While there is an incidental NO-related term, the overarching pattern is transporter activity for amino acids and related solutes, supporting a membrane transporter cluster rather than enzymes. High confidence.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070634","count":2},{"id":"GO:0097638","count":1},{"id":"GO:0035826","count":1},{"id":"GO:0071477","count":1},{"id":"GO:0042942","count":1}]},{"hash":"990971202538552896","title":"Translation Initiation and Ribosome Dynamics","description":"Top terms cluster around regulation of translation, initiation events, IRES-dependent initiation, preinitiation complex formation, ribosome disassembly, and translational fidelity, suggesting a cohesive theme of controlling protein synthesis at initiation and ribosome dynamics. A few outlier terms related to viral processes and X-chromosome dosage compensation appear but do not redefine the cluster's primary function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006417","count":1},{"id":"GO:0002188","count":1},{"id":"GO:0002192","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0009048","count":1}]},{"hash":"2061555262501585725","title":"Autophagy and vacuolar trafficking","description":"This cluster\u2019s top GO terms are dominated by autophagy- and vacuole-related processes: autophagy of mitochondrion, cytoplasm to vacuole targeting by the Cvt pathway, and piecemeal microautophagy of the nucleus, suggesting a shared role in delivering cellular components to the vacuole/lysosome for degradation. Other terms (e.g., molybdenum cofactor biosynthesis, tRNA wobble thiolation, protein neddylation) appear peripheral and do not cohere into a single alternative function, so the strongest theme is autophagy and vacuolar trafficking.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021764","count":3},{"id":"GO:0006777","count":3},{"id":"GO:0000422","count":3},{"id":"GO:0006501","count":3},{"id":"GO:0034727","count":3}]},{"hash":"1627000208559150894","title":"Mesodermal Development and Muscle Differentiation","description":"Top GO terms cluster around mesoderm formation, angiogenesis, and myotube differentiation, suggesting roles in mesoderm-derived tissue development and muscle formation. Additional terms about cellular responses to hormones and external stimuli may reflect signaling context but do not redefine the primary developmental theme.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001707","count":4},{"id":"GO:0007118","count":4},{"id":"GO:1905050","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0071375","count":4}]},{"hash":"1881335074269404830","title":"Vesicle trafficking and apoptotic signaling","description":"These terms collectively point to membrane trafficking activities (ER-Golgi/ER fusion, anterograde synaptic vesicle transport, lysosome localization) alongside apoptosis-related processes (extrinsic death receptor signaling and mitochondrial outer membrane permeabilization). The cluster appears to group proteins involved in intracellular transport coupled with components of apoptotic pathways, justifying a label that highlights both themes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016320","count":1},{"id":"GO:0048279","count":1},{"id":"GO:0048280","count":1},{"id":"GO:0097345","count":1},{"id":"GO:0048490","count":1}]},{"hash":"792659698667992895","title":"Muscle, heart, and neural differentiation","description":"The cluster\u2019s GO terms point to differentiation programs across muscle (myotube formation, myoblast regulation, muscle atrophy modulation), cardiac development (right ventricle formation, neural crest contribution to outflow tract), and neural processes (GABAergic neuron differentiation, myelination). This suggests a shared theme of developmental differentiation across muscle, heart, and nervous system tissues.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0014737","count":4},{"id":"GO:0003219","count":4},{"id":"GO:0021858","count":4},{"id":"GO:0043433","count":4},{"id":"GO:0045670","count":4}]},{"hash":"25286500085709390","title":"Glycolysis and Hypoxia/Oxidative Stress Response","description":"The top GO terms cluster around core metabolism (glycolysis, alanine catabolism) and stress responses (hypoxia, response to oxygen radicals, nutrient response), suggesting a group of proteins tied to energy production and cellular stress adaptation. Some developmental terms appear incidental and do not clearly define this cluster, so the label focuses on metabolic energy pathways and stress responses.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042853","count":2},{"id":"GO:0006096","count":2},{"id":"GO:2000648","count":2},{"id":"GO:0001666","count":2}]},{"hash":"1252364285313570234","title":"Chromatin Remodeling and Transcription Regulation","description":"The proteins show a clear emphasis on chromatin organization and transcription control, with terms like chromatin remodeling (GO:0043044) and regulation of transcription start site selection (GO:0001178). Although many entries are obsolete, the recurring theme centers on epigenetic regulation of gene expression rather than metabolism (the L-valine catabolic term appears incidental). This suggests the cluster reflects chromatin-mediated transcriptional regulation.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000616","count":1},{"id":"GO:0060303","count":1},{"id":"GO:0006574","count":1},{"id":"GO:0043044","count":1},{"id":"GO:0010425","count":1}]},{"hash":"1418248548763590031","title":"Diverse Biomolecule Biosynthesis","description":"The top GO terms span multiple biosynthetic pathways, including polyhydroxybutyrate polymer biosynthesis, GDP-mmannose and galactose metabolism, colanic acid exopolysaccharide biosynthesis, ADP-L-glycero-beta-D-manno-heptose biosynthesis, ether lipid biosynthesis, and pollen exine formation. There isn\u2019t a single cohesive pathway, but a unifying theme of synthesizing diverse biomolecules, so a broad \u201cbio-synthesis\u201d label fits. Confidence: Medium","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0019673","count":1},{"id":"GO:0006541","count":1}]},{"hash":"448103061231049399","title":"Ubiquitin/SUMO Proteostasis and Aggrephagy","description":"The prominent terms cluster around protein modification and degradation pathways\u2014sumoylation, ubiquitination, autoubiquitination, ERAD, and autophagic clearance of aggregates (aggrephagy)\u2014along with an oxidative stress response, all pointing to a cohesive role in proteostasis and stress management via ubiquitin/SUMO signaling. Some other terms (transcription regulation, cell cycle signals) suggest broader cellular regulation but do not outweigh the core proteostasis theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":3},{"id":"GO:0070301","count":2},{"id":"GO:0006357","count":2},{"id":"GO:0035973","count":2},{"id":"GO:0000753","count":2}]},{"hash":"235777646085598909","title":"Zinc transport and homeostasis","description":"The cluster is dominated by GO terms for zinc import across membranes, zinc ion homeostasis, and detoxification, with an additional outlier related to limb development. This points to a cohesive zinc transport/homeostasis module rather than unrelated processes.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006882","count":1},{"id":"GO:0060173","count":1},{"id":"GO:0044749","count":1},{"id":"GO:0006830","count":1},{"id":"GO:1903615","count":1}]},{"hash":"345408670601091025","title":"Golgi-ER Vesicle Transport and Exocytosis","description":"The GO terms point to vesicle trafficking between the ER and Golgi, Golgi organization, and various exocytic processes (including synaptic vesicle exocytosis and granule degranulation), indicating proteins involved in the secretory pathway and vesicle fusion. This cohesive theme supports labeling the cluster as vesicle transport and exocytosis within the Golgi-ER system.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016240","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0043308","count":3},{"id":"GO:0043312","count":3},{"id":"GO:0006888","count":3}]},{"hash":"1102248097288172970","title":"Developmental ECM Remodeling","description":"The cluster's GO terms cluster around extracellular matrix remodeling and organogenesis: collagen catabolic process, basement membrane disassembly, intramembranous ossification, decidualization, and lung branching morphogenesis all point to tissue remodeling during development. A broader term like regulation of catalytic activity is very general, and a single immune term (T cell mediated cytotoxicity) may be an outlier. Overall, the common theme is developmental remodeling of ECM and tissues.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":1},{"id":"GO:0030574","count":1},{"id":"GO:0046697","count":1},{"id":"GO:0050790","count":1},{"id":"GO:0034769","count":1}]},{"hash":"2270943952005188370","title":"Ubiquitin-Dependent ERAD and Proteostasis","description":"Top terms cluster around ubiquitin-dependent protein catabolic processes and ERAD, including autoubiquitination, suggesting these proteins function in ubiquitin-mediated degradation and quality control. The presence of aggrephagy and oxidative stress-related terms supports a broader proteostasis role under stress.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0051865","count":2},{"id":"GO:1903071","count":2},{"id":"GO:1903265","count":2},{"id":"GO:0070301","count":2}]},{"hash":"1583061917092825061","title":"Glycinergic Neurotransmission","description":"The top GO terms cluster around glycine handling at synapses\u2014glycine secretion, glycine import, and glycinergic synaptic transmission and its regulation. There are also related terms for serotonin uptake/secretion and dopamine catabolic process, which fit into broader neurotransmitter signaling. Overall, the strongest signal points to glycinergic neurotransmission as the central function of this protein cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905847","count":1},{"id":"GO:0051610","count":1},{"id":"GO:0061537","count":1},{"id":"GO:0042420","count":1},{"id":"GO:0036233","count":1}]},{"hash":"1555649822274594231","title":"Ubiquitin-Dependent Antiviral Signaling","description":"The top terms point to host antiviral responses, including negative regulation of viral replication/transcription, host-mediated suppression of viral processes, and the involvement of ubiquitination pathways (autoubiquitination and K63-linked ubiquitin). Additionally, there is regulation of NF-kappaB signaling and related immune pathways, suggesting a connected role in antiviral defense coordinated by ubiquitin signaling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901536","count":3},{"id":"GO:0045869","count":3},{"id":"GO:1901253","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0046597","count":3}]},{"hash":"1199455659086599536","title":"Ubiquitin-regulated antiviral signaling","description":"The GO terms cluster around modulation of antiviral pathways (positive regulation of RIG-I signaling), control of viral RNA replication, and ubiquitin-related processes (autoubiquitination, K63-linked ubiquitination), with a note on miRNA-mediated gene silencing. This suggests a small module where ubiquitin signaling intersects innate antiviral responses and RNA silencing, despite some unrelated terms present.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901536","count":3},{"id":"GO:0045869","count":3},{"id":"GO:1900246","count":3},{"id":"GO:1901253","count":3},{"id":"GO:2000637","count":3}]},{"hash":"294076839426756708","title":"Mitochondrial Translation and Energy Metabolism","description":"Enriched terms include mitochondrial translation and aminoacyl-tRNA biosynthesis via transamidation, suggesting mitochondrial protein synthesis; plus several catabolic pathways (fatty acids, galactose, inosine) and UDP-GlcNAc biosynthesis, indicating metabolic activity. ER and cell wall terms, and gravity detection appear peripheral, likely annotation noise, so the core theme is mitochondrial translation linked to energy metabolism.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007029","count":2},{"id":"GO:0019876","count":2},{"id":"GO:0070681","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0009062","count":2}]},{"hash":"690152521894096354","title":"Phospholipid and sphingolipid metabolism","description":"The GO terms cluster around phospholipid and sphingolipid metabolism and signaling (phosphatidylglycerol biosynthesis; phospholipid catabolic/dephosphorylation; sphingosine metabolism; regulation of sphingolipid signaling). Some Wnt-related terms are obsolete, which may reflect outdated annotations, but the dominant theme is lipid remodeling and lipid-mediated signaling.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0044329","count":1},{"id":"GO:0006655","count":1},{"id":"GO:0044328","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0009395","count":1}]},{"hash":"1384262512597364135","title":"Developmental morphogenesis across tissues","description":"The four proteins are collectively annotated with GO terms centered on development and tissue formation, including cartilage morphogenesis, skeletal muscle development, endocrine system development, left/right pattern formation, and embryonic placenta development. Although a couple terms (circadian sleep/wake cycle, phototropism) are less aligned with animal development, the dominant signal is broad developmental morphogenesis across multiple tissues. This makes a label focused on developmental programs and patterning most representative.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":1},{"id":"GO:0042748","count":1},{"id":"GO:0009638","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003323","count":1}]},{"hash":"1959179123405004092","title":"Neural signaling and morphogenesis","description":"The GO terms center on neural signaling components (acetylcholine metabolism, IP3 signaling, adenylate cyclase activation) and axon guidance/fasciculation, suggesting neural development roles, while accompanying terms reflect broader tissue morphogenesis (lung, kidney, nipple, ovarian follicle). This points to a cluster of proteins involved in signaling pathways shaping development across tissues. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060408","count":3},{"id":"GO:0060427","count":3},{"id":"GO:0032962","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0072224","count":3}]},{"hash":"1425013725471786514","title":"Actin cytoskeleton dynamics","description":"The cluster shows a set of GO terms centered on actin filament processes\u2014muscle filament sliding, vesicle transport along actin, actin patch assembly, and regulation of actin severing\u2014along with related themes in cell polarity, membrane organization, and phagocytic signaling. This points to a core function in actin cytoskeleton remodeling and its roles in trafficking and immune-related processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030049","count":2},{"id":"GO:0001768","count":2},{"id":"GO:0044656","count":2},{"id":"GO:0007118","count":2},{"id":"GO:0030050","count":2}]},{"hash":"379484296047516988","title":"Virion assembly and host-cell translocation","description":"This cluster is defined by GO terms for virion assembly and translocation of proteins into the host cell cytoplasm, pointing to viral-host interactions. The presence of immune-response and protein-folding related terms alongside these core viral processes suggests related cellular responses but the dominant theme remains virus-associated assembly and host entry.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044053","count":3},{"id":"GO:0002842","count":3},{"id":"GO:0019068","count":3},{"id":"GO:0033198","count":3},{"id":"GO:1903427","count":3}]},{"hash":"1333738954822188205","title":"Redox Homeostasis and Oxidative Stress Response","description":"The cluster\u2019s GO terms cluster around redox biology\u2014cell redox homeostasis, oxidant detoxification, hydrogen peroxide response, and deglutathionylation\u2014suggesting a shared theme of maintaining cellular redox balance, with a few terms (viral process, photoreceptor maintenance) likely incidental.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033158","count":1},{"id":"GO:0016032","count":1},{"id":"GO:0030416","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0080058","count":1}]},{"hash":"1872423592364525802","title":"Nuclear transport and mitosis","description":"This cluster is dominated by GO terms about transport into and out of the nucleus (nucleus import/export, tRNA export, ribosomal subunit export) and mitotic nuclear envelope dynamics (mitotic nuclear membrane disassembly, chromosome attachment to the nuclear envelope). These recurrent themes point to a nuclear transport/mitosis-centric function for the proteins, with some peripheral terms that may reflect broader regulatory connections. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010827","count":2},{"id":"GO:0007077","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0075733","count":2},{"id":"GO:0042306","count":2}]},{"hash":"744229265440171916","title":"RNA Methylation Enzymes","description":"The top GO terms point to a core of RNA modification and processing activities, including tRNA methylation, tRNA wobble uridine modification, rRNA methylation, RNA (guanine-N7)-methylation, and 7-methylguanosine mRNA capping, suggesting the proteins act as RNA methyltransferases or associated processing factors. While there are a few biosynthetic terms (cobalamin, chlorophyll, antibiotic biosynthesis) listed, they appear less central to the cluster\u2019s function. Overall, the dominant signal is RNA methylation machinery.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":1},{"id":"GO:0018027","count":1},{"id":"GO:0036068","count":1},{"id":"GO:0031167","count":1},{"id":"GO:0002098","count":1}]},{"hash":"26893544362696144","title":"Mesodermal development and myogenesis","description":"The top GO terms cluster around mesoderm formation, myotube differentiation, and angiogenesis, indicating a shared role in mesoderm-derived tissue development, particularly muscle formation and vascularization. Other responses to stimuli appear less central to the core function but may reflect signaling context. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001707","count":3},{"id":"GO:0007118","count":3},{"id":"GO:1905050","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0071375","count":3}]},{"hash":"1162224553640599050","title":"Cytoskeleton and membrane trafficking","description":"Although this cluster contains only three proteins with no direct interactions, the top GO terms cluster around cytoskeletal and transport-related processes, including spindle organization, actin filament bundle distribution, and vesicle transport along actin filaments, as well as membrane targeting and raft organization. Additional terms touch on pigment granule transport and phagocytosis signaling, all of which can be linked to cytoskeletal dynamics and vesicular trafficking, suggesting a loose theme of cytoskeleton-driven membrane trafficking rather than a single precise function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007051","count":1},{"id":"GO:0007118","count":1},{"id":"GO:0044855","count":1},{"id":"GO:0030050","count":1},{"id":"GO:0072678","count":1}]},{"hash":"311855771521718359","title":"Nucleotide salvage and catabolism","description":"The GO terms are dominated by salvage and catabolic processes for nucleosides and nucleobases (cytidine, uridine, inosine, guanosine, purine/pyrimidine salvage; interconversion), with an additional note on NAD biosynthesis salvage, suggesting a cohesive cluster of enzymes involved in reclaiming and restructuring nucleotides rather than de novo synthesis. Translation regulation appears minor in this context, so the core theme remains nucleotide salvage.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006216","count":2},{"id":"GO:0019358","count":2},{"id":"GO:0006152","count":2},{"id":"GO:0006218","count":2},{"id":"GO:0034356","count":2}]},{"hash":"2182318169622257269","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006747","count":1},{"id":"GO:0034628","count":1},{"id":"GO:1990966","count":1},{"id":"GO:0009611","count":1},{"id":"GO:0097171","count":1}]},{"hash":"1004917211628122714","title":"mRNA Splicing and Processing Regulation","description":"The top GO terms center on spliceosome-mediated mRNA splicing (including alternative splicing and its regulation), plus related post-transcriptional processes such as mRNA stability, translation initiation, and mRNA modification. This points to a coherent theme of post-transcriptional RNA processing control, especially splicing regulation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0048025","count":3},{"id":"GO:1901407","count":3}]},{"hash":"522432369635868848","title":"RNA splicing regulation and mRNA processing","description":"The GO terms cluster around spliceosome-mediated mRNA splicing (including both positive and negative regulation and alternative splicing), mRNA modification, and regulation of mRNA stability under stress, plus translation reinitiation and regulatory ncRNA\u2013mediated silencing. This pattern points to a group of proteins involved in post-transcriptional RNA processing and splicing regulation, especially in stress contexts.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0048025","count":2},{"id":"GO:1901407","count":2}]},{"hash":"821722091671081963","title":"Spliceosome Assembly and RNA Processing","description":"The top GO terms are dominated by spliceosome-related processes (spliceosomal complex assembly, snRNP assembly, mRNA splicing via spliceosome), with supporting terms for P-body assembly and rRNA maturation, pointing to a core function in RNA processing and splicing. While some chromatin-associated terms appear, they are secondary to the splicing theme.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009737","count":3},{"id":"GO:0033962","count":3},{"id":"GO:0000245","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0042633","count":3}]},{"hash":"144482415104769816","title":"Vesicle trafficking and endomembrane transport","description":"These proteins appear linked to membrane dynamics and vesicle movement, with GO terms spanning endosome transport (early to late), vacuole-ER tethering, and prospore membrane formation, plus related secretory processes like dense core granule maturation. The common thread is involvement in the endomembrane system and membrane remodeling, rather than a single specialized developmental pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990502","count":1},{"id":"GO:0000902","count":1},{"id":"GO:0032120","count":1},{"id":"GO:0051044","count":1},{"id":"GO:1904179","count":1}]},{"hash":"1641497959808128279","title":"DNA Damage Response and Sumoylation Regulation","description":"This cluster\u2019s GO terms cluster around DNA damage response and post-translational modification by SUMO: DNA double-strand break attachment to the nuclear envelope, positive regulation of intrinsic apoptotic signaling in response to DNA damage, and regulation/autosumoylation point to DDR processes and SUMO pathway control. While a few terms are broader, the dominant signal is DDR together with SUMO regulation, which likely reflects a cohesive functional theme among the involved proteins.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1990683","count":1},{"id":"GO:1902231","count":1},{"id":"GO:0003007","count":1},{"id":"GO:1990466","count":1},{"id":"GO:0016049","count":1}]},{"hash":"434406481371138719","title":"Protein Targeting and Folding","description":"This cluster is dominated by GO terms about targeting newly synthesized proteins to membranes (SRP-dependent cotranslational and post-translational targeting) and managing protein folding/unfolding (unfolded protein response, chaperone-assisted refolding). Together, these point to a coherent theme: protein biogenesis and quality control at the membrane, i.e., targeting and folding processes. A few outlier terms (DNA replication, iron-sulfur cluster assembly) do not align with this core, but the majority indicates a targeting/folding focus.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":1},{"id":"GO:0034620","count":1},{"id":"GO:0031204","count":1},{"id":"GO:0006616","count":1},{"id":"GO:1902037","count":1}]},{"hash":"1154961790785972848","title":"Ciliary assembly and neural patterning proteins","description":"This cluster centers on ciliary biology and development: non-motile cilium assembly and localization to the ciliary transition zone point to ciliogenesis, while neural tube patterning and embryonic digit morphogenesis indicate a developmental context where cilia signaling is important. ER targeting and protein trafficking terms support a role in delivering ciliary components. Together, they suggest a small module of ciliary assembly/trafficking linked to neural development.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042733","count":1},{"id":"GO:1905515","count":1},{"id":"GO:0021532","count":1},{"id":"GO:1904491","count":1},{"id":"GO:0006465","count":1}]},{"hash":"587421068813961359","title":"Amino acid and polyamine metabolism","description":"The terms center on biosynthesis and catabolism of amino acids and related amines (L-arginine, putrescine, ectoine) and acetylation processes, pointing to enzymes involved in amino acid and polyamine metabolism and osmoprotectant biosynthesis. Some terms (e.g., angiogenesis) seem unrelated or incidental, but the core theme is metabolic pathways for amino acids and polyamines. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":3},{"id":"GO:0045150","count":3},{"id":"GO:0019491","count":3},{"id":"GO:0032920","count":3},{"id":"GO:0071962","count":3}]},{"hash":"161711399399400249","title":"Glycinergic Synaptic Transmission","description":"The cluster shows multiple GO terms centered on glycine as a neurotransmitter (glycine secretion, glycine import, and glycinergic synaptic transmission, plus regulation of glycinergic transmission), with supporting references to serotonin and dopamine metabolism, suggesting proteins involved in glycine-mediated synaptic signaling and amino acid neurotransmitter handling at synapses. This cohesive theme justifies a label focused on glycinergic neurotransmission, with some broader monoaminergic context.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905847","count":1},{"id":"GO:0051610","count":1},{"id":"GO:0061537","count":1},{"id":"GO:0042420","count":1},{"id":"GO:0036233","count":1}]},{"hash":"1524093687474355384","title":"Immune signaling and apoptosis regulation","description":"In this small cluster, the dominant GO terms point to immune signaling and regulation of cell fate: positive regulation of T and B cell proliferation, TNF-mediated signaling, and regulation of apoptotic processes, along with a stress-response signal (response to hydrogen peroxide). While a few terms touch on embryonic development and peroxisome import, the strongest shared theme is immune activation and apoptosis control, suggesting these proteins cooperate in immune signaling and cell survival decisions under stress. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033092","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0070535","count":2},{"id":"GO:0016558","count":2},{"id":"GO:0033209","count":2}]},{"hash":"96514666830925683","title":"Vesicle trafficking and membrane transport","description":"Based on the GO terms enriched in this cluster, several items point to membrane-associated trafficking processes: endosome organization, synaptic vesicle exocytosis, and regulation of ARF protein signal transduction, which together reflect vesicle budding/trafficking. Additional terms about glucose transmembrane transport and fatty acid import support a broader membrane-transport theme. Some terms are more general or peripheral (response to food, IL-4 production), but the core signal appears to be vesicle trafficking and related transport activities.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010738","count":2},{"id":"GO:0046580","count":1},{"id":"GO:0032094","count":1},{"id":"GO:0015758","count":1},{"id":"GO:0007032","count":1}]},{"hash":"116403745613108538","title":"Unknown","description":"The top GO terms cover a broad and unrelated set of processes (proteasome assembly, chlorophyll biosynthesis, blood coagulation, dendrite regeneration, ion transport, cell adhesion, etc.), with no clear shared function binding the proteins. This lack of a coherent theme and the small counts prevent a specific, representative label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":2},{"id":"GO:0045123","count":2},{"id":"GO:1905050","count":2},{"id":"GO:0034113","count":2},{"id":"GO:0015995","count":2}]},{"hash":"758563072881460365","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms tied to ribosome-related functions: translation (GO:0006412), maturation of SSU-rRNA (GO:0000462), ribosome biogenesis and small subunit assembly (GO:0042254, GO:0000028). Additional terms about translational fidelity regulation and antibiotic response further support a ribosome-centric role, with RNA splicing and folding terms likely secondary connections. Overall, the theme is ribosome assembly and protein synthesis, justifying this label.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0000028","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006450","count":1}]},{"hash":"1653136656924533073","title":"Unknown","description":"The top GO terms are diverse, spanning cell wall assembly, lipid biosynthesis, methylation, translation initiation/reinitiation, proteasome assembly, deneddylation, chromatin regulation, and meiosis. With only three proteins and no clear shared function or cohesive pathway, there is no obvious common theme linking these terms, so a specific, representative label cannot be inferred.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071770","count":1},{"id":"GO:0008610","count":1},{"id":"GO:0032259","count":1},{"id":"GO:0070321","count":1},{"id":"GO:0000338","count":1}]},{"hash":"1135727010226469801","title":"Fruit ripening and hormone biosynthesis","description":"The GO terms cluster around plant hormone production and turnover (gibberellin, ethylene, auxin) plus processes tied to fruit ripening, including ethylene-driven maturation and related oxidative stress responses. A flavonoid biosynthetic process also fits ripening-associated metabolism; a single outlier (penicillin biosynthesis) does not override the overall theme. This suggests a cohesive function centered on hormone-regulated fruit ripening.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045487","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0009835","count":1},{"id":"GO:1902835","count":1},{"id":"GO:0009693","count":1}]},{"hash":"1944845996341627314","title":"Developmental signaling and cytoskeletal regulation","description":"The top GO terms mainly reflect developmental processes (gastrulation, multicellular organism development) along with signaling that regulates the cytoskeleton (positive regulation of GTPase activity, actin filament depolymerization) and growth pathways (positive regulation of TOR signaling, amino acid response). This suggests a coherent theme of developmentally driven signaling coordinating cytoskeletal dynamics and growth. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0016575","count":2},{"id":"GO:0007275","count":2}]},{"hash":"691900463793557364","title":"K63-Linked Ubiquitination and Synaptic Signaling","description":"The Top Terms cluster around K63-linked ubiquitination and neural/synaptic processes (synapse organization, transmission of nerve impulses, and receptor tyrosine kinase signaling), with additional terms for membrane repair and autoubiquitination. This suggests a theme where ubiquitin-dependent regulation modulates membrane-associated signaling at synapses, with some broader roles indicated by apoptosis and morphogenesis terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070534","count":3},{"id":"GO:0050808","count":3},{"id":"GO:0001778","count":3},{"id":"GO:2000059","count":3},{"id":"GO:0051865","count":3}]},{"hash":"514259208545622171","title":"Mitochondria-Linked Immune Signaling","description":"This cluster centers on immune signaling pathways (T cell polarity, TLR3 signaling, PKC signaling) and mitochondrial dynamics (stress-induced fusion, mtDNA replication), with membrane raft localization, suggesting a module where mitochondria coordinate immune signals at signaling platforms. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903905","count":3},{"id":"GO:1990046","count":3},{"id":"GO:0001302","count":3},{"id":"GO:0030433","count":3},{"id":"GO:1903044","count":3}]},{"hash":"803487479081019446","title":"Developmental Signaling and Inflammation","description":"GO terms point to developmental processes (gastrulation, skin development) with TGF-beta\u2013mediated signaling and inflammatory cytokine production, plus cytoskeletal remodeling, all suggesting a theme of signaling controlling development and immune-related responses; the connections are present but not tightly cohesive, giving a Medium confidence.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001403","count":2},{"id":"GO:0031954","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0031930","count":2}]},{"hash":"1074550307008241600","title":"Autophagy and mitochondrial stress with innate immune signaling","description":"This cluster combines terms tied to autophagy (autophagosome assembly; regulation of autophagy of mitochondrion), mitochondrial dynamics and stress (membrane potential and fusion regulation; necroptotic regulation), ER protein-folding stress, and innate immune pathways (NF-kappaB signaling, Toll-like receptor signaling, and negative regulation of antiviral defense). Together, these terms point to a cohesive theme where autophagy and mitochondrial stress interfaces modulate innate immune signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":1},{"id":"GO:0000045","count":1},{"id":"GO:0050689","count":1},{"id":"GO:0071157","count":1},{"id":"GO:0051881","count":1}]},{"hash":"492109047779703559","title":"Unknown","description":"The listed GO terms are highly diverse, spanning histone modification, cell cycle control, transcription regulation, plant hormone biosynthesis, neural tissue structure, and cholangiocyte proliferation, with no clear shared function or pathway tying the proteins together. Therefore a cohesive label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070535","count":1},{"id":"GO:0021693","count":1},{"id":"GO:0044810","count":1},{"id":"GO:0090282","count":1},{"id":"GO:0090419","count":1}]},{"hash":"1492283561223808694","title":"Unknown","description":"The GO terms associated with these proteins are highly diverse, covering metabolism (amino-acid betaine, guanine), stress and defense responses (herbicide, lipopolysaccharide), development (neural precursor proliferation, neuron projection), apoptosis, dopamine catabolism, and alternative splicing. There is no clear, shared biological function connecting them, so a consolidated label is not evident.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006579","count":1},{"id":"GO:0009635","count":1},{"id":"GO:0010725","count":1},{"id":"GO:0032496","count":1},{"id":"GO:2000179","count":1}]},{"hash":"40984739357054527","title":"Chaperone-mediated protein folding and microtubule assembly","description":"The GO terms cluster around chaperone-related activities (protein folding, chaperone-mediated complex assembly, ubiquitin-proteasome quality control) and microtubule-related processes (tubulin complex/ cortical microtubule organization), suggesting a cohesive theme of chaperone-assisted protein folding coupled to cytoskeletal assembly. Additional terms point to stress and mitochondrial context but do not override the central link between protein quality control and microtubule formation.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071629","count":1},{"id":"GO:0043622","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0007021","count":1},{"id":"GO:0051131","count":1}]},{"hash":"39043419973651586","title":"Lipid Biosynthesis and Membrane Homeostasis","description":"Top GO terms cluster around lipid biosynthesis (ergosterol and unsaturated fatty acids) and sphingolipid metabolism, with additional terms tied to lipid-rich tissues and membrane maintenance (sebaceous gland differentiation, CNS myelin maintenance). While some terms are broader (NO biosynthesis, mitochondrion inheritance), the shared theme appears to be lipid metabolism and membrane integrity. Confidence: Medium","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001949","count":3},{"id":"GO:0006809","count":3},{"id":"GO:0032443","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0006636","count":3}]},{"hash":"585027900353418212","title":"TNF/JNK Signaling and Apoptosis Regulation","description":"Based on the GO terms, the proteins are mainly involved in inflammatory/stress signaling (regulation of JNK cascade, TNF-mediated signaling) and cell fate decisions (apoptotic process). The presence of ubiquitination (K6-linked) supports regulation of signaling, while hints of histone modification and catabolic processes suggest accompanying transcriptional regulation layers often seen with stress responses. An outlier term about X chromosome dosage compensation is noted but does not align with the core theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085020","count":2},{"id":"GO:0046328","count":2},{"id":"GO:1903265","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0009048","count":2}]},{"hash":"1775071122660063566","title":"Collagen maturation via prolyl hydroxylation","description":"The terms center on proline hydroxylation to 4-hydroxyproline and collagen fibril organization, both key steps in collagen maturation and extracellular matrix assembly. The oxygen-dependent hydroxylation process links to intracellular oxygen homeostasis, supporting the idea of enzymes that require oxygen to modify collagen. Although a couple of terms are obsolete, the core signal points to collagen post-translational modification and ECM formation, making this a coherent cluster about collagen maturation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032364","count":1},{"id":"GO:0030199","count":1},{"id":"GO:0032504","count":1},{"id":"GO:1901874","count":1},{"id":"GO:0018401","count":1}]},{"hash":"804850406125485813","title":"ESCRT-driven MVB sorting","description":"The top GO terms cluster around ESCRT-mediated multivesicular body sorting and ubiquitin-dependent degradation (e.g., protein transport to vacuole via the MVB pathway and viral budding via host ESCRT). A few terms reflect unrelated processes, but the strongest shared theme is ESCRT/MVB trafficking and protein turnover.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043328","count":1},{"id":"GO:0071454","count":1},{"id":"GO:0030713","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0007076","count":1}]},{"hash":"2184342841721252486","title":"Transmembrane Transporters for Vitamins and Nutrients","description":"The top GO terms are centered on transmembrane transport of various small molecules (vitamins, xenobiotics, amino acids, metals) and related secretion processes, indicating a cohesive theme of membrane transport activity across substrates. This justifies a label focusing on membrane transporter function as representative of the cluster.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0042883","count":2},{"id":"GO:0015886","count":2},{"id":"GO:0030253","count":2}]},{"hash":"1518049209423827105","title":"Mitotic cell cycle regulation","description":"Most of the top GO terms point to regulation of the cell cycle and mitosis (G1/S transition, mitotic spindle pole separation, syncytial mitotic cycles, and general cell-cycle regulation), with supporting terms for transcriptional control and autophagy-related regulation (ULK1) that can be linked to cell-cycle checkpoints and cellular stress responses. Overall, the cluster appears to center on cell-cycle control and mitotic processes, with a few peripheral context-specific terms.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044828","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0030857","count":1},{"id":"GO:2001165","count":1},{"id":"GO:1905866","count":1}]},{"hash":"1211460024891296442","title":"Mitochondrial Metabolite and Ion Transport","description":"This cluster's GO terms cluster around transport across mitochondrial membranes (thiosulfate, iron, magnesium, citrate, phosphate), the malate-aspartate shuttle, and regulation of mitochondrial membrane permeability, with an ancillary note on fatty acid response. These collectively point to a cohesive function in mitochondrial transport and related metabolism.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015709","count":2},{"id":"GO:0097274","count":2},{"id":"GO:0048250","count":2},{"id":"GO:0006843","count":2},{"id":"GO:1990616","count":2}]},{"hash":"781795294636280504","title":"Immune response and inflammation","description":"The terms cluster around B cell immunity, response to LPS, TNF production, and inflammatory processes (plus fever-related regulation), indicating an immune activation/inflammatory signaling theme. A couple terms refer to non-immune physiological processes, suggesting only a partial but overall immune-related linkage. Thus the label reflects the dominant function with some noise. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019724","count":1},{"id":"GO:0071812","count":1},{"id":"GO:0048922","count":1},{"id":"GO:0060086","count":1},{"id":"GO:0006925","count":1}]},{"hash":"256867085249974266","title":"LPS-TLR innate immune signaling","description":"GO terms point to responses and signaling pathways activated by lipopolysaccharide through toll-like receptors, especially MyD88-dependent TLR signaling and TLR4 signaling. This suggests the cluster largely represents innate immune recognition of bacterial components. Some metabolism-related terms are present but do not define the group; the core theme is LPS/TLR signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905289","count":1},{"id":"GO:0046580","count":1},{"id":"GO:0002755","count":1},{"id":"GO:0019800","count":1},{"id":"GO:0071222","count":1}]},{"hash":"689838670172513353","title":"Neuronal development and GPCR signaling","description":"This cluster includes GO terms related to nervous system development, regulation of neuron apoptotic processes, and G protein-coupled opioid receptor signaling, suggesting a neuronal signaling/function theme. Several other terms about lipid metabolism or glycosylation appear ancillary rather than defining the core function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006696","count":1},{"id":"GO:0070207","count":1},{"id":"GO:0038003","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0043523","count":1}]}]