[{"hash":"2135671888518989352","title":"Lymphoid differentiation and cytokine signaling","description":"The enriched GO terms point to immune cell development and cytokine-driven signaling, including hemopoiesis, NK T cell differentiation, B cell maturation, IL-7 response, and IL-4 production. Rho/Rac signaling relates to cytoskeletal changes during immune-cell migration, while insulin-related terms appear ancillary. Overall, the cluster centers on lymphoid lineage development and cytokine-based regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0098761","count":6},{"id":"GO:0030097","count":6},{"id":"GO:0035020","count":6},{"id":"GO:2001275","count":6}]},{"hash":"1147100665287696278","title":"Mitochondrial respiration and translation","description":"This cluster shows a strong enrichment for mitochondrial energy metabolism: NADH dehydrogenase to ubiquinone, assembly of respiratory chain complexes II and IV, mitochondrial electron transport, proton transmembrane transport, and mitochondrial translation, with a general translation term also present. The occasional plastid-related term appears incidental, but the dominant theme is mitochondrial respiration and protein synthesis.","confidence":"High","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0055114","count":3},{"id":"GO:0006810","count":2},{"id":"GO:0019684","count":2},{"id":"GO:0006120","count":2}]},{"hash":"465456900234956234","title":"Actin Cytoskeleton Remodeling in Development and Motility","description":"The cluster is dominated by actin-related processes (filament bundle assembly, polymerization-dependent motility, barbed-end capping) and includes developmental contexts (bone and uterus development, distal tip cell migration) as well as NMDA receptor clustering and innate immune responses. This points to a unifying theme: actin cytoskeleton remodeling governing cell movement and structural organization across development, neural, and immune contexts.","confidence":"High","size":29,"edges":72,"triangles":37,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051017","count":24},{"id":"GO:0070358","count":24},{"id":"GO:0051016","count":24},{"id":"GO:0060348","count":24},{"id":"GO:1900029","count":24}]},{"hash":"654081543553346984","title":"Chromatin regulation and host-symbiont interactions","description":"The cluster is dominated by GO terms tied to chromatin-modifying processes (histone phosphorylation regulation, H3-K27 methylation, nucleolar transcription by RNA Pol I, transcription regulation, and dosage compensation) along with annotations about host interactions with symbionts or viruses (autophagy activation, ubiquitin-like protein modification perturbation, and viral genome replication). This suggests a cohesive theme around epigenetic regulation and host defense/modulation in the context of symbiotic or viral interactions. ","confidence":"Medium","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0033128","count":4},{"id":"GO:0060701","count":4},{"id":"GO:0039520","count":4},{"id":"GO:1904815","count":4},{"id":"GO:0045618","count":4}]},{"hash":"1958287747620730104","title":"Mitochondria-supported synaptic plasticity","description":"Based on the GO terms, this cluster combines mitochondrial energy-related processes (complex IV assembly, proton transmembrane transport) with neuronal signaling and plasticity (regulation of long-term synaptic plasticity, excitatory postsynaptic potential) and cytoskeletal dynamics (actin reorganization). It also touches on neurosensory functions (touch perception, balance) and receptor trafficking (internalization) as well as responses to ethanol and xenobiotics, suggesting a network that links energy supply to synaptic function and adaptive signaling at neurons. ","confidence":"High","size":29,"edges":90,"triangles":127,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":6},{"id":"GO:0048169","count":5},{"id":"GO:0050975","count":5},{"id":"GO:0060079","count":5},{"id":"GO:1902600","count":4}]},{"hash":"2055788874434561513","title":"Vertebrate organogenesis","description":"The top GO terms cluster around embryonic development and organ morphogenesis across multiple tissues (limb, heart, forebrain, retina) with supporting signs from cilium assembly and differentiation, suggesting a shared role in vertebrate organ formation rather than a single pathway. The glucocorticoid response term may reflect regulatory context during development rather than a core functional module.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030326","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0060271","count":2},{"id":"GO:0043011","count":2}]},{"hash":"1843979348956734386","title":"Transmembrane transporters for ions and metabolites","description":"The cluster is dominated by transmembrane transport GO terms (phosphate, vitamin, xenobiotic, potassium, glucose) and includes neurotransmitter loading into synaptic vesicles, pointing to a set of membrane transport proteins handling diverse substrates across membranes. While one term about replicative senescence is an outlier, the core theme is consistent across transport functions.","confidence":"High","size":29,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":21},{"id":"GO:0035461","count":20},{"id":"GO:0006855","count":20},{"id":"GO:0042891","count":17},{"id":"GO:0071805","count":17}]},{"hash":"1328521198278298961","title":"Neuronal development and synaptic signaling","description":"This cluster is dominated by nervous system and brain development terms, plus synaptic vesicle exocytosis and signaling pathways (Wnt and ERK), indicating roles in neuronal differentiation, synaptic function, and plasticity across the proteins. ","confidence":"High","size":29,"edges":285,"triangles":1406,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":10},{"id":"GO:0031532","count":10},{"id":"GO:0010796","count":10},{"id":"GO:0031384","count":10},{"id":"GO:2000300","count":10}]},{"hash":"1550529181727101588","title":"Notch signaling in vascular development and cell junctions","description":"The top GO terms cluster around Notch signaling and vascular development, including Notch signaling pathway, vasculogenesis and its positive regulation, and Notch receptor processing. Supporting terms like membrane localization and ectodomain proteolysis tie to Notch activation, while bicellular tight junction assembly points to endothelial/epithelial cell junctions. Together these suggest a coherent theme of Notch-mediated vascular development with mature cell\u2013cell junction dynamics.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007219","count":3},{"id":"GO:0001570","count":3},{"id":"GO:2001214","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0031623","count":3}]},{"hash":"987044922342484993","title":"Neural and cardiac morphogenesis","description":"The proteins cluster around neural development (subpallium neuron fate Commitment, oligodendrocyte development, auditory receptor cell fate determination, timing of subpallium differentiation) and heart development (endocardial cushion EMT for heart valve formation, sinus venosus morphogenesis, brain boundary morphogenesis). This points to a common theme of embryonic tissue patterning and organogenesis across brain and heart, with some overlap in developmental signaling pathways.","confidence":"High","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060163","count":29},{"id":"GO:2000981","count":29},{"id":"GO:2000802","count":29},{"id":"GO:0014003","count":29},{"id":"GO:0006959","count":29}]},{"hash":"1349490678799646081","title":"Developmental transcriptional regulators","description":"The top GO terms indicate broad transcriptional control by RNA polymerase II, with multiple development-related processes across organs (neural crest, retina, pancreas, bone, ureteric bud, digestive tract), suggesting a coordinated transcription factor network governing tissue development.","confidence":"Medium","size":29,"edges":369,"triangles":2763,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0000122","count":10},{"id":"GO:0006366","count":10},{"id":"GO:0090190","count":9},{"id":"GO:0048557","count":8}]},{"hash":"1013797942363161440","title":"Calcium-Driven Neural Plasticity and Cardiovascular Development","description":"Top GO terms indicate calcium signaling and synaptic plasticity (long-term potentiation, short-term memory) as central, with postsynaptic calcium regulation and calcium sensing. The presence of skeletal muscle development, heart rate regulation, and vascular morphogenesis suggests the cluster also ties into muscular and cardiovascular development, often mediated by calcium signaling and kinase activity. Together, these imply a calcium-dependent neural plasticity theme coupled with muscle and cardiovascular development.","confidence":"Medium","size":29,"edges":25,"triangles":7,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060291","count":15},{"id":"GO:0048741","count":15},{"id":"GO:0005513","count":15},{"id":"GO:0006469","count":15},{"id":"GO:0007614","count":14}]},{"hash":"1899172031623596441","title":"Complement and coagulation with ECM remodeling","description":"The top GO terms are dominated by complement activation (classical and lectin) and blood coagulation, plus collagen catabolic process, implying extracellular matrix remodeling linked to innate immune responses. Although there are separate terms for development and LPS response, the central theme connects immune activation and matrix turnover.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0007596","count":10},{"id":"GO:0006958","count":9},{"id":"GO:0030574","count":9},{"id":"GO:0001867","count":9}]},{"hash":"1296095747343246592","title":"Neuronal Synapse Plasticity and Spine Morphogenesis","description":"The terms show a cohesive theme around dendritic spine morphogenesis, synaptic plasticity (including long-term synaptic depression and regulation of excitatory postsynaptic potential), and neural communication relevant to auditory processing and social behaviors (sound perception, vocalization, social behavior), suggesting a cluster of proteins involved in synapse formation and activity-dependent remodeling in neural circuits.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0060997","count":8},{"id":"GO:0007605","count":8},{"id":"GO:0051835","count":8},{"id":"GO:0071625","count":7},{"id":"GO:0060292","count":7}]},{"hash":"76416015698579097","title":"Neuro-immune adhesion and signaling","description":"The top GO terms span neural functions (paranodal junction assembly, transmission of nerve impulse, synapse assembly) and immune activities (immunoglobulin production, complement activation, T cell proliferation) centered on cell adhesion and signaling (integrin-mediated and heterophilic adhesion). This suggests a cluster of proteins involved in adhesion and signaling shared between nervous system communication and immune responses, rather than a single isolated process.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001046","count":7},{"id":"GO:0030913","count":7},{"id":"GO:0019226","count":6},{"id":"GO:0002377","count":5},{"id":"GO:0086072","count":5}]},{"hash":"690525870921065865","title":"Neuroimmune Activation and Phagocytosis","description":"The top GO terms point mainly to immune system activity: complement activation, defense against bacteria, innate immune response, phagocytosis and its recognition, and B cell activation/signaling. These define a clear immune-activation theme. The presence of neuronal-related terms like excitatory postsynaptic potential and potassium ion transmembrane transport suggests a secondary neural signaling component or dual roles within this set, yielding a cluster centered on immune activation with a hint of neural signaling.","confidence":"Medium","size":29,"edges":4,"triangles":1,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":11},{"id":"GO:0050910","count":11},{"id":"GO:0042742","count":10},{"id":"GO:0045087","count":9},{"id":"GO:0006911","count":9}]},{"hash":"1751599088188055120","title":"Cardiac muscle contraction and sarcomere organization","description":"This cluster is dominated by GO terms tied to heart and muscle function: cardiac muscle contraction, heart development, and sarcomere organization, indicating proteins mainly involved in cardiac muscle structure and contractile function; additional signaling terms (Rho/Ras regulation) and a few non-muscle terms appear less central to the core theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0045214","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0010765","count":3}]},{"hash":"1726928483963791139","title":"Membrane ion and metabolite transporters","description":"This cluster centers on a broad set of transmembrane transport activities, including potassium and sodium ion transport, phosphate and sugar/metabolite transport, and even neurotransmitter loading into vesicles, indicating a common theme of transporting ions and small molecules across membranes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071805","count":6},{"id":"GO:0035725","count":4},{"id":"GO:0015824","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0006182","count":3}]},{"hash":"430330116936119564","title":"Spliceosome-Mediated mRNA Splicing and Export","description":"The cluster is dominated by GO terms for mRNA splicing via the spliceosome, including regulatory and alternative splicing, along with mRNA export and stress granule localization. This points to a cohesive group of RNA processing factors that function in spliceosome-mediated splicing and subsequent mRNA handling, especially under stress. ","confidence":"High","size":28,"edges":377,"triangles":3250,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":18},{"id":"GO:0031047","count":18},{"id":"GO:0000398","count":15},{"id":"GO:0010610","count":15},{"id":"GO:0016973","count":11}]},{"hash":"238093721104860846","title":"T cell activation and cytoskeletal signaling","description":"I named it this because the top GO terms center on T cell receptor\u2013mediated activation, integrin- and Rho/Rac-regulated signaling, and cytoskeletal remodeling, with supporting terms for hematopoiesis and cytokine responses (IL-7, IL-4), as well as hyaluronan metabolism related to extracellular matrix interactions during immune cell trafficking. This combination points to a coherent theme of T cell activation and adhesion signaling with cytoskeletal dynamics.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030212","count":18},{"id":"GO:0002291","count":18},{"id":"GO:0035023","count":17},{"id":"GO:0007229","count":16},{"id":"GO:0098761","count":15}]},{"hash":"1841561974394981663","title":"Developmental signaling and angiogenesis","description":"The proteins in this cluster are enriched for signaling-related GO terms across development and growth, including KIT signaling, PI3K/AKT signaling, regulation of angiogenesis, axon regeneration, and reproductive development (ovulation and thyroid development). This pattern suggests a broad theme of developmental signaling pathways coordinating growth, neural/vascular remodeling, and reproductive processes rather than a single, specific function. ","confidence":"Medium","size":28,"edges":349,"triangles":2617,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048679","count":28},{"id":"GO:0002688","count":28},{"id":"GO:0042698","count":28},{"id":"GO:0038109","count":28},{"id":"GO:1902002","count":28}]},{"hash":"1961294301892279962","title":"Immune signaling and cell communication","description":"The top GO terms show strong signals for innate immune response and adaptive receptor signaling (T cell and B cell receptors), indicating a core immune signaling theme. Additional terms for integrin- and ephrin-mediated signaling, and transcytosis, point to cell\u2013cell communication and trafficking. While Wnt signaling and heart development appear, the predominant pattern is immune signaling merged with cell communication pathways, suggesting a cohesive cluster centered on immune cell signaling and interactions. ","confidence":"Medium","size":28,"edges":57,"triangles":16,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":9},{"id":"GO:0090263","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0048013","count":8},{"id":"GO:0050852","count":8}]},{"hash":"667494806316778326","title":"Neural development and axon regeneration","description":"The top terms are dominated by nervous system development and regulation of axon regeneration, both with strong representation (28 hits each), indicating a neural development/regrowth focus. Peripheral terms like PMA response and metallopeptidase activity suggest signaling and remodeling but do not outweigh the central neural theme; several obsolete terms can be ignored. High","confidence":"","size":28,"edges":344,"triangles":2493,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048679","count":28},{"id":"GO:1902002","count":28},{"id":"GO:1990801","count":28},{"id":"GO:1904628","count":28},{"id":"GO:0030878","count":28}]},{"hash":"847937901059330203","title":"GPCR-Mediated cAMP/cGMP Signaling","description":"This cluster is enriched for GPCR signaling, adenylyl cyclase activation, and biosynthesis of cAMP and cGMP, with a broader intracellular signal transduction theme and links to transcription regulation; hypoxia detection and forskolin response further anchor it in second-messenger signaling controlling gene expression.","confidence":"High","size":28,"edges":52,"triangles":52,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0052565","count":24},{"id":"GO:0001973","count":24},{"id":"GO:0071880","count":24},{"id":"GO:0070483","count":24},{"id":"GO:1900194","count":24}]},{"hash":"815843050578517183","title":"RNA processing and silencing machinery","description":"This cluster is dominated by RNA-related processes: translation, RNA editing, primary miRNA processing, RISC complex assembly, and mRNA stabilization, plus rRNA catabolic activity. Together they point to RNA metabolism and RNA interference pathways as the core theme. A few terms (dosage compensation, spinal cord morphogenesis, and response to toxic substances) seem less central and may reflect broader context or annotation noise.","confidence":"High","size":28,"edges":183,"triangles":769,"max_degree":23,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0045071","count":7},{"id":"GO:0009636","count":7},{"id":"GO:0006382","count":7},{"id":"GO:0009047","count":6}]},{"hash":"1531315553298142493","title":"mRNA Splicing and Translation Regulation","description":"The cluster is dominated by GO terms related to mRNA maturation and translation control, including mRNA splicing via the spliceosome (cis and alternative), regulation of polyadenylation, mRNA export from the nucleus, and components of the translation preinitiation complex and reinitiation, with some links to ncRNA-mediated gene silencing. This combination suggests a cohesive module centered on post-transcriptional processing and subsequent translation regulation.","confidence":"High","size":28,"edges":12,"triangles":6,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:1900363","count":6},{"id":"GO:0001731","count":5},{"id":"GO:0000380","count":5},{"id":"GO:0002188","count":5}]},{"hash":"292799496927393860","title":"Embryonic development and transcriptional regulation","description":"This cluster combines wide-ranging developmental terms (cerebellum, eye, pituitary, muscle, and general multicellular organism development) with transcriptional regulation (negative and positive regulation of transcription by RNA Pol II, transcription by RNA Pol II), suggesting a coherent module of genes coordinating transcription control during embryonic development and organogenesis, including processes like motor neuron axon guidance and myoblast proliferation.","confidence":"High","size":28,"edges":26,"triangles":0,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":16},{"id":"GO:0021549","count":13},{"id":"GO:0008045","count":13},{"id":"GO:0021983","count":13},{"id":"GO:0007275","count":13}]},{"hash":"1282680553043513139","title":"Neural Differentiation and Brain Development","description":"This cluster is dominated by GO terms related to neuronal differentiation and neural development (cerebellar Purkinje cell differentiation, visceral motor neuron differentiation, midbrain dopaminergic neuron differentiation, ectoderm formation), indicating a coherent theme of neural development. Supporting terms like actin filament bundle assembly and receptor clustering further suggest cytoskeletal remodeling and membrane organization typical of neurite outgrowth during neural differentiation. An outlier term about lipoteichoic acid biosynthesis appears unrelated, but does not negate the overall neural-development signal.","confidence":"High","size":28,"edges":102,"triangles":76,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":8},{"id":"GO:0090179","count":7},{"id":"GO:0043113","count":7},{"id":"GO:0021702","count":7},{"id":"GO:0021524","count":7}]},{"hash":"1054624211524142286","title":"Steroid and Retinoid Biosynthesis","description":"The top GO terms cluster around biosynthetic pathways for steroids, retinoids, and related lipids (e.g., C21-steroid hormone biosynthesis, estrogen biosynthesis, retinoic acid biosynthesis, retinal metabolism, sphingolipid biosynthesis). This suggests a coherent theme of lipid- and pigment-related biosynthesis among the proteins, despite a few outliers like antibiotic biosynthesis and methotrexate response.","confidence":"High","size":28,"edges":18,"triangles":8,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0042574","count":10},{"id":"GO:0008207","count":10},{"id":"GO:0030148","count":10},{"id":"GO:0002138","count":10}]},{"hash":"1296619705517640278","title":"Calcium-Dependent Morphogenesis Signaling","description":"The terms cluster around calcium signaling regulation (calcineurin-NFAT, postsynaptic calcium concentration, ryanodine channel activity) and morphogenesis-related processes (dendrite and blood vessel morphogenesis, EMT), suggesting a theme of calcium-mediated control of developmental morphogenesis. Some terms are more divergent (xenobiotic response, ascospore formation), but the dominant pattern centers on calcium-regulated signaling in morphogenesis.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050774","count":9},{"id":"GO:0001569","count":6},{"id":"GO:0051531","count":6},{"id":"GO:0099566","count":6},{"id":"GO:0001837","count":6}]},{"hash":"1978241816002014709","title":"Muscle and adipose differentiation with stress responses","description":"The top GO terms point to skeletal muscle regeneration and fat cell differentiation, alongside cellular stress responses (heat/cold) and modulation processes like ubiquitination and mRNA processing. The presence of tissue remodeling signals (e.g., hepatocyte apoptotic process, NOD1 signaling) suggests a cluster centered on differentiation/remodeling of muscle and adipose tissues under stress, rather than a single defined pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0098907","count":10},{"id":"GO:0007205","count":10},{"id":"GO:0045444","count":9},{"id":"GO:0016567","count":9},{"id":"GO:0009408","count":9}]},{"hash":"1239591591495658843","title":"Skin Development and Innate Immunity","description":"The top GO terms cluster around skin and multicellular development (skin development, multicellular organism development) while also emphasizing innate immune responses (defense against Gram-positive bacteria, cellular response to lipopolysaccharide, innate immune response, response to LPS, interferon-beta production). This combination suggests these proteins are involved in both skin development and innate immune signaling, with some related intracellular processes (protein localization to microtubules, nuclear export regulation) that may support these functions. Therefore, the label reflects the cluster\u2019s core theme: skin development linked to innate immune defense.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":11},{"id":"GO:0050830","count":9},{"id":"GO:0043588","count":9},{"id":"GO:0006915","count":8},{"id":"GO:0035372","count":7}]},{"hash":"242177400144935814","title":"DNA Damage Response and Apoptosis","description":"The top terms cluster around DNA repair (base-excision repair) and apoptotic processes, with supporting signals from oxidative stress responses (redox homeostasis, hydrogen peroxide response) and signaling regulation (phosphatidylinositol dephosphorylation, mRNA stability). This suggests a cohesive theme of cellular response to DNA damage and oxidative stress, with transcriptional/post-transcriptional and signaling layers; a couple of terms (infection structure formation, obsolete glycosylation) may reflect annotation noise or context-specific roles.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0075015","count":4},{"id":"GO:0006486","count":4},{"id":"GO:0045454","count":3}]},{"hash":"1726412541977573502","title":"Neural and vascular development with ECM remodeling","description":"The terms cluster around collagen fibril organization (ECM), angiogenesis regulation, axonogenesis, synapse assembly, and RTK signaling, along with mechanotransduction and immune signaling pathways. This suggests a cohesive theme of signaling and extracellular matrix remodeling guiding neural and vascular development, with mechanical cues influencing cell behavior. While immune-related terms exist (LPS signaling), the dominant pattern points to ECM-associated signaling in neural/vascular contexts.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014068","count":7},{"id":"GO:0016525","count":6},{"id":"GO:0030199","count":6},{"id":"GO:0014911","count":5},{"id":"GO:0031663","count":5}]},{"hash":"1660821799831232910","title":"GTPase-regulated signaling and vesicle trafficking","description":"Most represented terms center on regulation/activation of small GTPases, phosphatidylinositol-mediated signaling, and vesicle trafficking (endosome to Golgi transport, Cvt pathway). The presence of NF-kappaB signaling and regulatory terms for neutrophil degranulation and blood vessel remodeling suggests a broader signaling coordination role rather than a single enzymatic activity. Together these point to a theme of GTPase-driven signal transduction linked to vesicular transport, with several regulatory processes, yielding a coherent but moderately broad cluster. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0048015","count":3},{"id":"GO:0043314","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0010765","count":3}]},{"hash":"655490220851622890","title":"Unknown","description":"The top terms are spread across telomere maintenance, spindle assembly and chromosome localization, with additional unrelated signaling and development terms, giving no single cohesive function for this protein set.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":13},{"id":"GO:0097284","count":12},{"id":"GO:1900383","count":12},{"id":"GO:1904908","count":12},{"id":"GO:0071901","count":12}]},{"hash":"771452533140906165","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":30,"triangles":19,"max_degree":9,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0007420","count":7},{"id":"GO:0044205","count":7},{"id":"GO:0006207","count":7},{"id":"GO:0007507","count":6},{"id":"GO:0050873","count":6}]},{"hash":"1189740289059008776","title":"Glycinergic neurotransmission and glycine transport","description":"The dominant GO terms center on glycine-mediated signaling\u2014glycinergic synaptic transmission, glycine secretion, glycine import/transport, and regulation of glycinergic signaling\u2014indicating a cohesive glycine-focused neurotransmission module. The additional brain-related terms (thalamus development, monoamine uptake) suggest neural context and glial interactions, but the glycine-related terms form the core theme of this cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042066","count":11},{"id":"GO:0060012","count":11},{"id":"GO:0042420","count":11},{"id":"GO:0061537","count":11},{"id":"GO:0021794","count":11}]},{"hash":"729779773471725018","title":"Adrenergic GPCR signaling with dopaminergic transmission","description":"Top GO terms center on adrenergic receptor signaling and GPCR activation (GO:0010579, GO:0007190), dopaminergic synaptic transmission (GO:0001963), and MAPK pathways linked to adrenergic receptors (GO:0071883). Additional terms reflect autonomic regulation of physiological processes such as blood pressure, thermogenesis, saliva secretion, and pain perception, with energy metabolism hints from the electron transport chain. Together, this cluster appears to consist of proteins involved in sympathetic/adrenergic signaling and associated dopaminergic neurotransmission.","confidence":"High","size":28,"edges":42,"triangles":1,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":23},{"id":"GO:0022900","count":22},{"id":"GO:0046541","count":22},{"id":"GO:0045777","count":22},{"id":"GO:0002024","count":21}]},{"hash":"422571211399414025","title":"Pain Perception and Thermogenesis Neural-Vascular Signaling","description":"This cluster centers on neural signaling related to pain and temperature, alongside pathways governing thermogenesis, membrane potential, neuropeptide signaling, vascular tone, and smooth muscle regulation. The mix of terms like sensory perception of pain, diet-induced thermogenesis, cellular response to temperature stimulus, vasoconstriction, neuropeptide signaling, and Rho signaling suggests a coordinated neural-vascular/metabolic theme rather than a single isolated process. A notable immune cue (lipopolysaccharide response) hints at broader context but does not negate the core neural-thermogenic-vasculature motif.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0002024","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0042391","count":14},{"id":"GO:0022900","count":13}]},{"hash":"405791774724943312","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster is dominated by GO terms related to ubiquitination and ubiquitin-mediated turnover, including ubiquitin-dependent protein catabolic process, multiple forms of ubiquitination (K6-linked, polyubiquitination), ERAD-related pathways, and autoubiquitination, with links to regulation of signaling (JNK, TNF) and innate immune responses. This suggests a cohesive function centered on tagging proteins for degradation and modulating proteostasis and signaling via ubiquitin pathways.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0085020","count":7},{"id":"GO:0030433","count":6},{"id":"GO:0046328","count":6},{"id":"GO:0036205","count":6}]},{"hash":"179143885173007562","title":"Glial-endothelial barrier maintenance and ion transport","description":"This cluster\u2019s top GO terms cluster around glial-endothelial barrier function (establishment of the glial blood-brain barrier, negative regulation of endothelial cell proliferation) and ion homeostasis (potassium and sodium ion transmembrane transport), with supporting signals related to mechanical stimulus response and immune/inflammatory pathways (IL-8 production, LPS signaling, defense against Gram-positive bacteria). Together these suggest a coherent theme of barrier integrity and ion transport at the neurovascular interface, with accompanying immune modulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0060857","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071260","count":2}]},{"hash":"832983544159851620","title":"Heart and cochlea development signaling","description":"The top terms are dominated by heart development and cochlea morphogenesis, suggesting enrichment for developmental signaling related to cardiac and inner-ear organogenesis. Related signaling pathways (GPCR acetylcholine signaling, TNF signaling) and membrane trafficking align with broader developmental regulation, though the remaining terms are diverse. Overall, the cluster appears to reflect signaling networks guiding heart and cochlear development.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0090103","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0007213","count":3},{"id":"GO:0005975","count":2}]},{"hash":"723958968640261701","title":"MAPK pathway negative regulation and cell cycle control","description":"The top GO terms point to suppression of MAPK/ERK signaling (negative regulation of ERK cascade, phosphatase-mediated dephosphorylation) alongside cell cycle/mitotic processes (kinetochore localization, meiotic spindle disassembly). This suggests a cluster enriched in phosphatases and regulators that dampen MAPK activity while coordinating cell division, with some links to VEGF signaling and vascular permeability. Overall, the theme is signaling pathway regulation, especially MAPK, connected to cell cycle control.","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":25},{"id":"GO:0000200","count":25},{"id":"GO:0050860","count":25},{"id":"GO:0007049","count":19},{"id":"GO:0035335","count":19}]},{"hash":"2248480366542376874","title":"Cardiac development and cardiomyocyte signaling","description":"The cluster is dominated by heart-related GO terms: heart development and outflow tract morphogenesis, Purkinje-to-ventricle signaling, SA node and atrial action potential regulation, and calcium release from the sarcoplasmic reticulum, all pointing to cardiomyocyte function, electrophysiology, and development. A broader developmental term (ossification) appears, but the core signal centers on cardiac structure and signaling pathways.","confidence":"High","size":27,"edges":69,"triangles":42,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":18},{"id":"GO:0043931","count":17},{"id":"GO:1903244","count":14},{"id":"GO:0014808","count":13},{"id":"GO:0086029","count":13}]},{"hash":"1177808286683571212","title":"Neuronal development and dense core granule exocytosis","description":"The cluster is driven by brain development and a key neurosecretory function: positive regulation of dense core granule exocytosis, plus brain development terms. Phosphatidylinositol metabolism supports membrane signaling needed for vesicle trafficking, and other terms reflect general cellular growth processes. Together, these terms point to neuronal differentiation and regulated secretory pathways as the core theme.","confidence":"Medium","size":27,"edges":262,"triangles":1422,"max_degree":26,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1900087","count":8},{"id":"GO:0046488","count":8},{"id":"GO:0007420","count":8},{"id":"GO:0006260","count":7},{"id":"GO:0001975","count":7}]},{"hash":"1174314191511273392","title":"Innate Immune Activation and Inflammasome Assembly","description":"The cluster shows strong enrichment for innate immune response, defense against Gram-positive bacteria, NLRP3 inflammasome complex assembly, and interleukin-1 production, plus ubiquitin-proteasome\u2013related protein turnover and MHC class I biosynthesis regulation. These terms together point to a cohesive theme of innate immune signaling and inflammasome-mediated cytokine production, with regulatory ubiquitination processes. The presence of both inflammasome and cytokine-related terms supports a focused label around innate immunity and inflammasome activity.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":11},{"id":"GO:0090307","count":10},{"id":"GO:0032088","count":10},{"id":"GO:0031146","count":10},{"id":"GO:0050830","count":10}]},{"hash":"2001485839749019871","title":"Unknown","description":"The top terms cover very diverse biological themes\u2014tissue development (retina), lipid metabolism, immune cell proliferation, signaling activation, redox processes, nucleotide biosynthesis, gasotransmitter production, protein assembly, osmoprotectant transport, and nuclear import\u2014without a clear unifying function. Because the proteins appear to participate in disparate pathways rather than a single coherent process, I cannot assign a concise, representative label beyond Unknown.","confidence":"","size":27,"edges":154,"triangles":706,"max_degree":21,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0060041","count":14},{"id":"GO:0006633","count":13},{"id":"GO:0046651","count":13},{"id":"GO:0032147","count":13},{"id":"GO:0055114","count":13}]},{"hash":"635680869599400867","title":"Epithelial junctions and cytoskeleton remodeling","description":"The cluster centers on assembly and regulation of epithelial cell junctions (bicellular tight junctions, cell polarity) and actin-driven structures (filopodia, ruffles, podosomes), with involvement of small GTPase signaling and endocytosis. This combination strongly indicates coordinated junction formation and cytoskeletal remodeling at epithelial contacts, sometimes linked to Wnt pathway modulation.","confidence":"High","size":27,"edges":95,"triangles":38,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070830","count":8},{"id":"GO:1900026","count":7},{"id":"GO:0046847","count":7},{"id":"GO:0007264","count":7},{"id":"GO:0090263","count":6}]},{"hash":"1514271219173560679","title":"Immune signaling and angiogenic cell migration","description":"The proteins in this cluster link adaptive immunity (adaptive immune response, B cell maturation) with signaling pathways (ERK cascade, Rho signaling) and cytoskeletal/motility processes (lamellipodium and podosome assembly, response to mechanical stimulus) that drive endothelial cell migration and angiogenesis. This combination suggests a coherent theme where immune activation interfaces with vascular remodeling and cell motility.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002250","count":13},{"id":"GO:0070374","count":12},{"id":"GO:0043536","count":12},{"id":"GO:0035023","count":11},{"id":"GO:2001275","count":11}]},{"hash":"448332264401117114","title":"Nervous system development and synaptic signaling","description":"Based on the top GO terms, the cluster is enriched for nervous system development, transmission of nerve impulses, axon guidance, and regulation of glutamatergic synaptic transmission, with ROBO signaling supporting axon pathfinding. The presence of endosome transport suggests associated protein trafficking relevant to synaptic function, while a few terms like defense response and spermatid development appear as secondary associations. Overall, the dominant theme is neuronal development and synaptic communication.","confidence":"High","size":27,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0019226","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0045022","count":4},{"id":"GO:0051966","count":4}]},{"hash":"594704449105344484","title":"Unknown","description":"The top GO terms point to a highly diverse mix: spermatid nucleus differentiation, thymus and spleen development, epithelial cell polarity, neural/synaptic localization, and behavioral responses, plus transcriptional regulation. With little network connectivity (one edge, zero triangles) and no clear shared function, there isn\u2019t a coherent functional theme tying these proteins together. Therefore the cluster label should be Unknown.","confidence":"","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007289","count":5},{"id":"GO:0097284","count":4},{"id":"GO:0090162","count":3},{"id":"GO:0035641","count":3},{"id":"GO:0000122","count":3}]},{"hash":"1956522439778918485","title":"NF-kappaB-driven inflammatory signaling","description":"The cluster centers on inflammatory response and NF-kappaB pathway activity, including lipopolysaccharide signaling and positive regulation of canonical NF-kappaB signaling, with supporting roles for ubiquitination, autophagy, and anti-apoptotic processes. While a couple terms (myelination, telomere capping) are less directly linked, the dominant theme is NF-kB\u2013mediated inflammatory signaling.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0016567","count":3}]},{"hash":"1975610333606026156","title":"MAPK signaling in neural development","description":"Top GO terms point to MAPK pathway regulation (ERK/JNK), nervous system development, axonogenesis, and cytoskeletal regulation, suggesting a coherent group of proteins that modulate MAPK signaling to drive neural differentiation and related cytoskeletal remodeling.","confidence":"High","size":27,"edges":17,"triangles":2,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":26},{"id":"GO:0007399","count":25},{"id":"GO:0031647","count":25},{"id":"GO:0070374","count":25},{"id":"GO:0046330","count":25}]},{"hash":"364752795335132811","title":"Unknown","description":"Top GO terms span apoptosis, visual perception, brain development, transcription, signaling pathways, and cell cycle, with no single dominant function connecting them. The lack of network edges (Edges: 0) and the diverse terms suggest these proteins do not form a coherent functional module, so a descriptive label cannot be confidently assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0032092","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0008286","count":3}]},{"hash":"889697311520729425","title":"ERAD and Autophagy Protein Quality-Control Cluster","description":"The cluster is dominated by GO terms related to ubiquitin-dependent protein quality control in the ER (ERAD), deubiquitination (multiple linkage types), and autophagy-related processes (including aggrephagy and regulation of autophagosome maturation). These together point to a cohesive theme of proteostasis management via ER-associated degradation and autophagy, with overlap into deglycosylation and signaling pathways that can intersect with proteostasis (e.g., ERK, Hippo). Overall, the proteins appear to function as a network for maintaining protein homeostasis through ubiquitin-mediated ERAD and autophagic pathways.","confidence":"Medium","size":27,"edges":14,"triangles":3,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1904378","count":5},{"id":"GO:0035523","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0044313","count":4},{"id":"GO:0070374","count":4}]},{"hash":"73643623160829243","title":"Ubiquitin-Dependent Protein Degradation Network","description":"The top GO terms point to ubiquitin-mediated protein catabolic processes (ERAD), autoubiquitination, and histone ubiquitination, indicating a core focus on ubiquitin tagging and proteasomal turnover. Additional terms involve regulation of JNK and TNF signaling, and even V(D)J recombination, suggesting this cluster also touches on immune signaling and chromatin-related processes that are often controlled by ubiquitination. Together, these terms support a cohesive module around protein quality control and signaling regulation via ubiquitin pathways.","confidence":"High","size":27,"edges":16,"triangles":2,"max_degree":6,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:1903265","count":12},{"id":"GO:0030433","count":11},{"id":"GO:0051865","count":10},{"id":"GO:0033151","count":9}]},{"hash":"1695917555272759103","title":"Dopamine and Adrenergic GPCR Signaling","description":"This cluster is dominated by GPCR-related signaling terms, especially dopamine and adrenergic receptor pathways, with downstream effects on cAMP, PLC, and ERK cascades, and includes related processes like phototransduction and heart development. The convergence on receptor-mediated signaling and downstream kinase cascades suggests a coherent GPCR signaling module across neural/cardiac contexts.","confidence":"High","size":27,"edges":342,"triangles":2714,"max_degree":26,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":20},{"id":"GO:0007507","count":20},{"id":"GO:0071880","count":19},{"id":"GO:0007603","count":19},{"id":"GO:0007191","count":19}]},{"hash":"811499593421318804","title":"Neural development and cytoskeletal signaling","description":"This cluster is dominated by terms tied to neural morphogenesis and polarity (convergent extension, neural plate elongation, neural tube closure PCP references, cochlea morphogenesis) as well as cytoskeletal and transport processes (intracellular transport, Rho signaling, microtubule localization) and related signaling (JNK activity). The combination suggests a cohesive theme around neural development and cytoskeletal regulation rather than a single linear pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0019933","count":3},{"id":"GO:0022007","count":3}]},{"hash":"196676260680374492","title":"Embryonic development and morphogenesis","description":"This cluster\u2019s GO terms cluster around developmental processes across multiple tissues and lineages during embryogenesis\u2014pancreatic cell development, heart-related EMT, placental and trophoblast differentiation, cartilage morphogenesis, left-right patterning, and endocrine system development\u2014with supporting terms on transcriptional regulation and immune-related components that can participate in developmental remodeling. The common theme is differentiation and organogenesis during embryonic development, making this a coherent developmental/morphogenetic cluster.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060806","count":5}]},{"hash":"793169026717663795","title":"Vesicle trafficking and signaling regulators","description":"This cluster is enriched in GO terms describing negative regulation of signaling pathways (Rho, Ras, NF-kappaB) and processes tied to vesicle trafficking and exocytosis (synaptic vesicle priming, acrosome reaction). The diversity of contexts (neutrophil degranulation, blood vessel remodeling, mating projection growth) points to a shared role for these proteins as regulators of vesicle release and signal transduction across cell types, rather than a single specific pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0010796","count":7},{"id":"GO:0035023","count":6},{"id":"GO:0043314","count":6},{"id":"GO:0060313","count":6},{"id":"GO:0043124","count":5}]},{"hash":"1080521528661433715","title":"Vascular signaling and angiogenesis","description":"The top GO terms center on cGMP biosynthesis and neuropeptide signaling, which regulate vascular tone and blood pressure, while extracellular matrix disassembly and cell migration related to sprouting angiogenesis point to vessel formation and remodeling. Although digestion and acute-phase responses are broader, the dominant signal is vascular signaling and angiogenic remodeling.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006182","count":3},{"id":"GO:0007218","count":3},{"id":"GO:0008217","count":3},{"id":"GO:0007586","count":2},{"id":"GO:0006953","count":2}]},{"hash":"1399894198744742483","title":"Rho GTPase\u2013driven actin cytoskeleton in muscle development","description":"The GO terms cluster around Rho family GTPase signaling and actin dynamics (positive regulation of GTPase activity, regulation of Rho protein signal transduction, actin filament-based movement, microspike assembly) together with sarcomere organization and skeletal muscle fiber development, pointing to a shared theme of cytoskeletal remodeling driving muscle morphogenesis. Some terms also touch on centrosome and spindle assembly, reflecting broader cell division contexts, but the dominant signal is Rho-regulated actin control in muscle growth and structure.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0051661","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0030035","count":4}]},{"hash":"1012501528427840944","title":"Embryonic Development and Morphogenesis","description":"Top GO terms cluster around developmental processes and tissue morphogenesis across multiple organs (endocardial cushion EMT, cartilage morphogenesis, hair follicle morphogenesis, placenta development, left-right patterning, pancreatic development), indicating a cohesive theme of embryonic differentiation and morphogenesis. Some terms reflect general RNA processing, but the dominant pattern supports a development/morphogenesis label.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060707","count":3}]},{"hash":"2245251818108196044","title":"Cardiac Electrophysiology","description":"This cluster is dominated by GO terms related to cardiac electrical activity and conduction: regulation of heart rate by cardiac conduction, SA node cell action potential, and regulation of ventricular/atrial membrane depolarization and repolarization. These collectively point to cardiac electrophysiology. Some immune-related terms (innate immune response, complement activation, phagocytosis) and adhesion terms appear as secondary associations, suggesting broader annotations for the same proteins, but they do not define the core theme of this cluster.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0086091","count":8},{"id":"GO:0006958","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0060307","count":8},{"id":"GO:0060371","count":8}]},{"hash":"2009259581050735137","title":"Rho/Rac-mediated actin dynamics and cell migration","description":"The GO terms cluster around actin cytoskeleton remodeling and cell movement, driven by the Rho family GTPases (Rho and Rac), including lamellipodium/filopodium assembly, regulation of GTPase signaling, and processes like endocytosis that link cytoskeletal changes to migration. This suggests a cohesive role in regulating actin dynamics to control cell motility.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0090051","count":5},{"id":"GO:0030032","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0031532","count":5}]},{"hash":"1543880216038038111","title":"Neural development and synapse assembly","description":"The top GO terms are dominated by nervous system development (GO:0007399), transmission of nerve impulse, paranodal junction assembly, myelination, and positive regulation of synapse assembly, which collectively point to neural development and synaptic organization. Other terms like heart development, ossification, and complement activation are present but less central, possibly reflecting broader developmental processes or multi-tissue annotation. Therefore the label captures the cluster's main theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0019226","count":7},{"id":"GO:0030913","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1525212758535876893","title":"Dopaminergic and Adrenergic Neurotransmission with Autonomic Regulation","description":"The cluster is dominated by GO terms for dopaminergic synaptic transmission and adrenergic receptor\u2013mediated signaling, including MAPK-activating pathways and heart rate regulation by epinephrine/norepinephrine. Additional terms point to autonomic control of organ systems (prepulse inhibition, enteric smooth muscle differentiation) and related stress responses (xenobiotic exposure, TNF regulation), suggesting a cohesive theme of neural/autonomic signaling modulating cardiovascular and sensorimotor functions.","confidence":"High","size":27,"edges":105,"triangles":144,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":25},{"id":"GO:0071883","count":25},{"id":"GO:0001996","count":25},{"id":"GO:0048609","count":25},{"id":"GO:0051967","count":25}]},{"hash":"162725157305806095","title":"Wnt signaling and ECM remodeling in development","description":"The top GO terms cluster around signaling (Wnt pathway) and extracellular matrix remodeling (collagen organization and catabolic processes, proteolysis), along with developmental processes such as endodermal differentiation and eye morphogenesis. This suggests a shared role for these proteins in developmental signaling coordinated with ECM remodeling, with some additional but less central terms related to mechanical response, synapse assembly, and immune-related processes.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0071260","count":6},{"id":"GO:0016055","count":6},{"id":"GO:0006508","count":6},{"id":"GO:0030199","count":5}]},{"hash":"1970600876943015388","title":"GPCR-Driven Metabolic and Sensory Signaling","description":"The cluster shows a mix of GO terms centered on receptor-mediated signaling (adenylate cyclase-activating GPCR pathway, Rho signaling, PI biosynthesis) and broad sensory/metabolic roles (diet-induced thermogenesis, cellular response to temperature, phototransduction, pain perception, blood pressure, bone remodeling). This suggests proteins that participate in diverse, downstream signaling cascades coordinating metabolic state with sensory and vascular functions, rather than a single narrow process. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0035025","count":7},{"id":"GO:0010579","count":7}]},{"hash":"127251205899042767","title":"Cardiac development and contraction","description":"Top GO terms strongly point to cardiac biology, with heart development (GO:0007507) and cardiac muscle contraction (GO:0060048) as well as a cellular response to mechanical stimulus (GO:0071260) indicating cardiomyocyte function and mechanoresponse. While there are other terms related to development and immune processes, they appear auxiliary to the cardiac-focused signals. Therefore, the cluster likely represents proteins involved in cardiac development and contractile function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:0001782","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0007507","count":4}]},{"hash":"240888740662840858","title":"Wnt-driven organ morphogenesis and angiogenesis","description":"The top GO terms emphasize Wnt signaling (including planar cell polarity), organ morphogenesis (e.g., ureteric bud branching) and angiogenesis, with supporting terms like fibroblast migration and multicellular growth, suggesting a cluster of proteins involved in developmental signaling and vascular/organ formation rather than a single pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":4},{"id":"GO:0010761","count":3},{"id":"GO:2000379","count":2},{"id":"GO:2000096","count":2},{"id":"GO:0001525","count":2}]},{"hash":"170122417212956849","title":"Embryonic organ and endocrine development","description":"The proteins are annotated by GO terms that cluster around embryonic development and endocrine system formation\u2014pancreatic cell development, endocardial cushion EMT, trophoblast differentiation, cartilage morphogenesis, placenta development, and left-right patterning\u2014indicating a coherent theme of organogenesis and hormonal system development.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0003323","count":12},{"id":"GO:0003198","count":12},{"id":"GO:0060707","count":12},{"id":"GO:0060536","count":12},{"id":"GO:0060806","count":12}]},{"hash":"1503089154247245034","title":"Innate immunity and neural-ECM remodeling","description":"The cluster shows enrichment for innate immune response, collagen fibril organization, axonal fasciculation, synapse assembly, and sensory perception of sound, plus responses to mechanical stimulus and remodeling-related processes like PI3K signaling and endothelial migration. This pattern points to a theme where immune activity intersects with extracellular matrix dynamics and nervous system development/remodeling, rather than a single isolated pathway. Confidence: Medium","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0071260","count":5},{"id":"GO:0006915","count":5},{"id":"GO:2001275","count":4},{"id":"GO:0030199","count":4}]},{"hash":"1376805597857527802","title":"Ephrin signaling and developmental patterning with adhesion","description":"This cluster is enriched for terms related to developmental patterning (anterior/posterior specification; heart and uterus development) and signaling via the ephrin receptor pathway, alongside cell adhesion and Rho-mediated signaling. These together point to a coordinated program of tissue patterning and adhesion dynamics likely driven by ephrin signaling. Some peripheral terms (peroxisome localization, unfolded protein response) seem less central to the core theme, so the focus remains on patterning, adhesion, and ephrin signaling.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0009952","count":8},{"id":"GO:0048013","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0060065","count":8},{"id":"GO:1900026","count":7}]},{"hash":"1073610180166815460","title":"Actin cytoskeleton remodeling and endocytosis in neurons","description":"The proteins cluster around actin cytoskeleton dynamics (cortical patch assembly, polymerization, barbed-end capping) and endocytosis, with neuron development as a notable context; additional signaling terms (GTPase activity, tyrosine phosphorylation) and TGF-beta response likely reflect related pathways. Overall, the shared theme is actin-driven membrane trafficking relevant to neurons.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0006897","count":6},{"id":"GO:0000147","count":6},{"id":"GO:0030041","count":6},{"id":"GO:0051016","count":6}]},{"hash":"1439693451587475333","title":"Developmental signaling pathways","description":"The cluster is dominated by GO terms tied to development and signaling across tissues, notably nervous system development, axon guidance, Slit-Robo signaling, and Hedgehog (Smoothened) signaling, with supporting roles in ERK signaling and organ development (kidney, ossification). While it also touches immune-related signaling (T cell receptor signaling, mast cell chemotaxis), the strongest and most coherent theme is developmental signaling networks guiding cell fate, migration, and tissue patterning, particularly neural development and axon guidance. ","confidence":"High","size":26,"edges":253,"triangles":1306,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":20},{"id":"GO:0035385","count":20},{"id":"GO:0043931","count":20},{"id":"GO:0050852","count":20},{"id":"GO:0007224","count":19}]},{"hash":"1850270812655057894","title":"Neuropeptide-regulated feeding and thermogenesis","description":"The cluster is dominated by neuropeptide signaling and appetite-related GO terms (neuropeptide signaling pathway, eating behavior, positive regulation of appetite) along with metabolic/thermogenic signals (diet-induced thermogenesis, cellular response to temperature, electron transport chain) and GPCR-adenylate cyclase signaling, pointing to a neuroendocrine module that links food intake with energy expenditure.","confidence":"High","size":26,"edges":19,"triangles":10,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0007190","count":14}]},{"hash":"767545245908010934","title":"Cardiovascular and neural development signaling","description":"The Top Terms show strong signals for heart development and nervous system development, plus axon guidance (Roundabout pathway) and neuron-related regulation, all pointing to developmental signaling in cardiac and neural contexts. Additional terms on GPCR signaling, ERK cascade, ubiquitination, and immune-related differentiation hint at broader signaling networks involved in differentiation and cell communication, but the dominant theme is developmental signaling in heart and nervous system. ","confidence":"Medium","size":26,"edges":3,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0007399","count":6},{"id":"GO:0035385","count":6},{"id":"GO:0043525","count":6},{"id":"GO:0045444","count":5}]},{"hash":"1138309377768057643","title":"Rho GTPase-driven cytoskeleton and adhesion","description":"The cluster is dominated by GO terms for regulation of Rho signaling, actin cytoskeleton organization, GTPase activity, and cell adhesion/spreading, pointing to a cohesive theme of cytoskeletal remodeling and adhesion mediated by Rho family proteins (with some related developmental terms present).","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:1900026","count":4},{"id":"GO:0007155","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1234386480694000208","title":"Apoptosis and Growth Signaling Regulation","description":"This cluster is dominated by the apoptotic process term (GO:0006915) and enriched for multiple signaling-regulation terms, including positive regulation of Wnt signaling, Hippo signaling, insulin receptor signaling, and growth hormone signaling, along with keratinocyte and immune-related differentiation. The convergence on cell fate decisions and growth/signaling pathways suggests a cohesive theme around how apoptosis interacts with growth and differentiation signaling in tissue contexts.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":22},{"id":"GO:0060044","count":22},{"id":"GO:0090263","count":22},{"id":"GO:0030216","count":22},{"id":"GO:0035329","count":22}]},{"hash":"1410420827030952975","title":"Dopaminergic signaling and sensory processing","description":"This cluster is dominated by neural signaling terms: dopaminergic synaptic transmission, sensory perception (pain, vision), visual learning, and behavioral responses to cocaine, along with related intracellular signaling like ERK cascade and prostaglandin response. These point to brain-based signaling and processing of sensory information and behavior, with a few peripheral terms (heart development, thermogenesis) that are less core to the theme. Overall, the strongest common thread is neural signaling linked to sensory processing and behavior.","confidence":"Medium","size":26,"edges":206,"triangles":627,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":20},{"id":"GO:0071380","count":19},{"id":"GO:0070374","count":19},{"id":"GO:0010759","count":19},{"id":"GO:0008542","count":19}]},{"hash":"571326806116060993","title":"Ubiquitin-Dependent Proteolysis and Circadian Regulation","description":"The strongest signals are ubiquitin-related processes (ubiquitin-dependent protein catabolic process, protein polyubiquitination, positive regulation of protein polyubiquitination) together with regulation of circadian rhythm, suggesting the cluster centers on ubiquitin-mediated protein turnover and its connection to circadian timing. Other terms like synapse assembly and B cell signaling are present but less cohesive with the core theme.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":22},{"id":"GO:0042752","count":17},{"id":"GO:0060386","count":10},{"id":"GO:0000209","count":10},{"id":"GO:0050853","count":9}]},{"hash":"1542334908801584641","title":"Triglyceride and phospholipid catabolism","description":"This cluster\u2019s top GO terms are dominated by lipid metabolism: triglyceride catabolic/remodeling processes and triglyceride mobilization, along with phosphatidylcholine and phosphatidylethanolamine catabolic activities. These points suggest a shared function in lipid turnover and membrane remodeling. A few terms (paranodal junction assembly, heterophilic cell-cell adhesion, complement activation) are less central to this lipid-focused theme, but do not override the main pattern.","confidence":"Medium","size":26,"edges":120,"triangles":192,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0030913","count":7},{"id":"GO:0034638","count":6},{"id":"GO:2000480","count":6},{"id":"GO:0036153","count":6}]},{"hash":"1511818033730447503","title":"Vertebrate embryonic morphogenesis and organogenesis","description":"The top GO terms cluster around embryonic development and morphogenesis across various organs (heart outflow tract, cartilage, limbs, palate, teeth, eye, ureteric bud branching, primitive streak). This suggests a coherent theme of vertebrate embryo patterning and organ formation, with transcriptional regulation playing a coordinating role. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0003148","count":13},{"id":"GO:0051216","count":12},{"id":"GO:0008584","count":12},{"id":"GO:0035116","count":12}]},{"hash":"1206897700146244053","title":"Developmental transcription regulation and chromatin remodeling","description":"The cluster is enriched for transcriptional control and chromatin remodeling terms (negative regulation of transcription by RNA Pol II, DNA-templated transcription, chromatin remodeling) along with multiple embryonic development processes (neural crest cell migration, midbrain development, endocrine pancreas development, embryonic digestive tract morphogenesis, ureteric bud morphogenesis). This pattern points to proteins that regulate gene expression during development, coordinating tissue morphogenesis via chromatin and transcriptional machinery.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0031018","count":8},{"id":"GO:0043046","count":7},{"id":"GO:0048557","count":7},{"id":"GO:0006351","count":7}]},{"hash":"1052474318679115770","title":"Neuronal development and synaptic signaling","description":"The top GO terms center on nervous system development and synaptic processes (nervous system development, positive regulation of synapse assembly, regulation of synaptic vesicle exocytosis, ERK cascade), suggesting the proteins in this cluster are involved in neural development and synaptic transmission/plasticity. While some terms reflect general cellular processes (ribosomal export, stress fiber assembly) or immune signaling (T cell receptor pathway), the neural-related terms are most representative of the cluster\u2019s function. Confidence: Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0090051","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0051496","count":3},{"id":"GO:0050852","count":3}]},{"hash":"761089609049363554","title":"Neural signaling and behavior regulation","description":"The GO terms predominantly describe neuronal signaling and plasticity (Rho/GTPase signaling, LTD) along with behavioral aspects such as sensory perception of sound, vocalization, and social behavior, suggesting a cluster of proteins involved in neural communication and regulation of social/communication behaviors. Some terms related to immunity and endocytosis are present but less central to the main theme. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0090630","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0048260","count":2},{"id":"GO:0002860","count":2}]},{"hash":"1064918858874215726","title":"Innate immune signaling and actin remodeling","description":"The GO terms point to innate and inflammatory immune responses (innate immune response, inflammatory response, defense against bacteria) along with actin cytoskeleton changes (actin filament network formation, cell spreading), suggesting a module linking immune signaling to cytoskeletal remodeling in inflammation and barrier contexts.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":3},{"id":"GO:0070493","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0002344","count":3},{"id":"GO:0050830","count":3}]},{"hash":"163827098790988888","title":"Neural development and synaptic plasticity","description":"This cluster centers on neuronal development and synaptic regulation, with terms like regulation of Rho signaling (cytoskeleton/neurite dynamics), long-term synaptic depression, axonal fasciculation, and dendritic spine development, plus related behavioral and ethanol-response hints. A heart development term is present but less representative of the dominant neural theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0035176","count":4},{"id":"GO:0014068","count":3}]},{"hash":"2208222786379779874","title":"Immune activation and signaling","description":"The cluster is dominated by GO terms related to innate and adaptive immune responses, including B cell receptor signaling, defense against virus, and general immune activation, with accompanying regulatory signaling pathways (JNK cascade, NF-kB activity, Rho/GTPase signaling) and protein turnover. This points to a cohesive theme of immune cell activation and signaling rather than a single structural role, despite one outlier term like bone development. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":12},{"id":"GO:0050853","count":9},{"id":"GO:0002250","count":8},{"id":"GO:0046328","count":8},{"id":"GO:0042787","count":8}]},{"hash":"1800750159079254238","title":"Nuclear transport and mitosis","description":"The top GO terms cluster around nuclear-cytoplasmic transport and mitotic processes: mRNA export, hnRNP import, ribosomal subunit export, Ran signaling, and kinetochore localization, all tying into mitotic cell cycle progression. Transcription regulation and GTPase activity terms also align with regulatory control during these nuclear events, supporting a theme of nuclear transport coupled with cell division.","confidence":"High","size":25,"edges":297,"triangles":2232,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0034501","count":5},{"id":"GO:0006406","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0000278","count":4}]},{"hash":"1420714369565877324","title":"MAPK Regulation and Endosomal Sorting","description":"These proteins are enriched for GO terms related to negative regulation of MAPK signaling cascades (ERK1/2 and p38), alongside ubiquitin-dependent protein catabolic processes via multivesicular body sorting. The co-occurrence of MAPK inhibition and endosomal/ESCRT-associated protein turnover suggests a functional cluster of regulators that dampen signaling through MAPK pathways and coordinate turnover of signaling components via endosomal sorting, with additional ties to vesicle-related processes such as dense core granule maturation and neuronal signaling.","confidence":"High","size":25,"edges":119,"triangles":289,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":15},{"id":"GO:0043162","count":14},{"id":"GO:0030948","count":12},{"id":"GO:0000173","count":11},{"id":"GO:0000200","count":11}]},{"hash":"1179324585341813141","title":"Rho GTPase-driven junctional actin remodeling","description":"This cluster centers on tight junction assembly, actin dynamics (filopodium formation, barbed-end capping), and Rho/small GTPase signaling, plus ephrin receptor signaling. The convergence of these terms points to coordinated remodeling of the actin cytoskeleton at cell\u2013cell contacts and adhesion-associated processes like transcytosis and substrate spreading, making junctional actin remodeling the best unifying theme.","confidence":"High","size":25,"edges":193,"triangles":813,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":6},{"id":"GO:0035023","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0007264","count":4}]},{"hash":"844790506102154924","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":168,"triangles":571,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045454","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0034975","count":5},{"id":"GO:0070389","count":4}]},{"hash":"2175325962248848551","title":"Broad Signaling and Regulation","description":"The top GO terms center on diverse signaling and regulatory processes\u2014GPCR signaling, NOD1/2 signaling, NF-kB regulation, and ubiquitination\u2014along with broader processes like cell migration, development, and the cell cycle. This indicates a cluster of proteins involved in various signaling pathways and regulatory mechanisms rather than a single, cohesive function, justifying a broad signaling/regulation label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0071260","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0016567","count":7}]},{"hash":"723187972891640429","title":"Mesenchymal Stem Cell-Driven Bone Formation","description":"The cluster is dominated by terms tied to mesenchymal cell behavior, bone trabecula formation, cell-matrix adhesion, and regulation of Hedgehog signaling (Smoothened), along with positive regulation of mesenchymal stem cell proliferation and differentiation. This points to mesenchymal stem cells orchestrating skeletal development and bone formation through ECM interactions and signaling pathways, with some ECM sequestration of morphogens (TGF\u03b2/BMP) reinforcing the matrix-centric regulation. Dendrite regeneration appears as a broader shared process but does not override the core skeletal/MSC theme.","confidence":"High","size":25,"edges":124,"triangles":275,"max_degree":20,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007275","count":19},{"id":"GO:0060346","count":18},{"id":"GO:0007160","count":18},{"id":"GO:0045880","count":18},{"id":"GO:0090497","count":17}]},{"hash":"457022580926109049","title":"mRNA splicing regulation and translation initiation","description":"This cluster is dominated by GO terms tied to spliceosome-mediated mRNA splicing and its regulation, plus components involved in assembling the translation preinitiation complex and the eIF4F complex, with additional mRNA modification and stress-related stability regulation, indicating a cohesive role in RNA processing and initiation of translation.","confidence":"High","size":25,"edges":273,"triangles":1767,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":18},{"id":"GO:0048025","count":14},{"id":"GO:0048026","count":13},{"id":"GO:0031047","count":13},{"id":"GO:0000398","count":12}]},{"hash":"439121063020523927","title":"Cell adhesion and synapse assembly proteins","description":"The dominant GO terms point to cell-cell adhesion (heterophilic and homophilic) and regulation of synapse assembly, with additional signals of specialized tissue adhesion (AV node) and immune modulation. These collectively suggest a cluster of adhesion molecules (likely including cadherin/Ig-family) that mediate intercellular contacts and synapse organization, while also influencing immune cell interactions and extracellular matrix contexts.","confidence":"High","size":25,"edges":28,"triangles":1,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":16},{"id":"GO:0051965","count":15},{"id":"GO:0007156","count":14},{"id":"GO:0043931","count":14},{"id":"GO:0045087","count":13}]},{"hash":"1967399590554780740","title":"Neuronal axon growth and mitochondrial dynamics","description":"These terms cluster around neuron development and mitochondrial dynamics: axon extension, synaptic localization, microtubule organization, and intracellular mitochondria distribution/regulation. The inclusion of mitochondrial fission and membrane potential regulation further supports roles in mitochondrial dynamics within neurons. Overall, the proteins appear to function in axon growth with coordinated mitochondrial and cytoskeletal regulation in neurons.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902474","count":5},{"id":"GO:0045773","count":5},{"id":"GO:0090258","count":4},{"id":"GO:0001578","count":4},{"id":"GO:0032930","count":4}]},{"hash":"2251231510310036930","title":"Neural development and axon guidance","description":"This cluster is dominated by terms tied to neuronal differentiation and connectivity, including neurogenesis, axonogenesis, peripheral nervous system axon regeneration, dendrite self-avoidance, and chemorepulsion in neuron migration, all underpinned by Rho signaling regulating cytoskeletal dynamics. Some terms reference broader developmental processes (eye photoreceptors, myoblast fusion, pericyte differentiation), but the core theme centers on neural development and axon guidance.","confidence":"Medium","size":25,"edges":278,"triangles":1880,"max_degree":24,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":21},{"id":"GO:0007520","count":20},{"id":"GO:0001751","count":16},{"id":"GO:0070593","count":16},{"id":"GO:0021836","count":16}]},{"hash":"917760561683013436","title":"Cardiac GPCR Signaling","description":"Several GO terms point to G protein-coupled receptor signaling and heart function (acetylcholine receptor signaling, GPCR internalization, desensitization, and cardiac muscle contraction). This suggests the cluster centers on GPCR-mediated regulation of cardiac activity, with some peripheral associations to broader GPCR roles (e.g., visual perception, oxidative stress response) that are less core. Overall, the theme is GPCR-driven cardiac signaling and contraction regulation.","confidence":"High","size":25,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0070301","count":4},{"id":"GO:0002029","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007213","count":4}]},{"hash":"1918244298849301014","title":"Translation initiation and mRNA processing regulation","description":"The top GO terms cluster around eukaryotic translation initiation (preinitiation complex formation, eIF4F assembly, translation reinitiation) and RNA processing/splicing (spliceosome-mediated regulation, mRNA modification, ncRNA-mediated gene silencing), suggesting a cohesive group coordinating translation with mRNA processing. ","confidence":"High","size":25,"edges":73,"triangles":54,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":17},{"id":"GO:0002188","count":17},{"id":"GO:0048026","count":17},{"id":"GO:0031047","count":17},{"id":"GO:1901407","count":16}]},{"hash":"1093359167428191421","title":"Sensory Perception and Thermal Signaling","description":"Predominant GO terms point to sensory modalities (pain, touch) and temperature-related responses (thermogenesis, cold), with additional hints of membrane excitability (potassium transport, cardiac repolarization) and signaling (cAMP). A few terms on development/cerebellum maturation may reflect broader neuronal context. Overall, the cluster centers on sensory perception intertwined with thermosensory signaling and membrane excitability.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0002024","count":10},{"id":"GO:0098914","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0050976","count":10}]},{"hash":"1892151532280214002","title":"Transcription Regulation and Developmental Signaling","description":"The top GO terms center on transcriptional control (negative regulation of transcription by RNA Pol II; DNA-templated transcription) and various signaling/developmental processes (TGF-beta response, TORC1 signaling, retina development, follicle cell development). The presence of trafficking and translation initiation terms suggests a broader regulatory/communication role rather than a single pathway, so a label focusing on transcription regulation and developmental signaling best captures the cluster theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0072583","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043547","count":2}]},{"hash":"2214507327826830514","title":"Developmental transcriptional regulation","description":"This cluster is enriched for transcription by RNA polymerase II and multiple development-related terms across tissues (retina, inner ear, thyroid, pituitary, forebrain), indicating proteins involved in regulating gene expression during organ development. The shared theme is transcription-driven developmental programs.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":18},{"id":"GO:0060041","count":17},{"id":"GO:2000288","count":15},{"id":"GO:0021913","count":15},{"id":"GO:0030878","count":15}]},{"hash":"749662643625330093","title":"Glycinergic Synaptic Transmission","description":"Based on the strong representation of glycine-related terms (glycine secretion, glycine import, and regulation of glycinergic synaptic transmission) and related neural context terms (perineurial glial growth, thalamus development), the cluster appears to center on glycinergic neurotransmission in the brain. Dopamine and serotonin terms align with general brain signaling but do not override the glycinergic theme; the convergence on glycine signaling strongly supports this label.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042066","count":7},{"id":"GO:0060012","count":7},{"id":"GO:0042420","count":7},{"id":"GO:0061537","count":7},{"id":"GO:0021794","count":7}]},{"hash":"571411215639250000","title":"Embryonic morphogenesis and organ development","description":"The terms cluster around embryonic development and morphogenesis across diverse organs (eye, brain habenula, midbrain, hindlimb, placenta, gonad, heart). A transcriptional regulation term also aligns with developmental control, supporting a label of broad embryonic morphogenesis.","confidence":"High","size":25,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":12},{"id":"GO:0000122","count":12},{"id":"GO:0021986","count":11},{"id":"GO:0043010","count":11},{"id":"GO:0030901","count":11}]},{"hash":"1218750086600604126","title":"Embryonic neural, vascular, and musculoskeletal development","description":"The top GO terms point to broad vertebrate embryonic development across neural, vascular, and musculoskeletal lineages (floor plate development; subpallium and amacrine cell differentiation; somitogenesis; bronchiole and lung vasculature development; skeletal muscle differentiation; vascular wound healing). This suggests a cohesive theme of transcriptionally driven tissue differentiation during development, spanning multiple organ systems. ","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":22},{"id":"GO:0071277","count":12},{"id":"GO:0001756","count":12},{"id":"GO:0033504","count":12},{"id":"GO:0060426","count":12}]},{"hash":"359625210970242783","title":"Embryonic organogenesis and morphogenesis","description":"This cluster shows a coherent pattern of embryonic development processes across multiple organs and tissues, including eye, tooth (odontogenesis), limb, palate, lung, and heart outflow tract morphogenesis, as well as gastrulation-related primitive streak formation. The prominence of transcription by RNA polymerase II suggests coordinated gene expression driving these developmental programs, supporting a theme of embryonic organogenesis and morphogenesis.","confidence":"High","size":25,"edges":186,"triangles":575,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0048048","count":14},{"id":"GO:0042475","count":13},{"id":"GO:0035116","count":13},{"id":"GO:0008584","count":13}]},{"hash":"436055330961236345","title":"Mitotic progression and DNA repair","description":"The set is dominated by mitosis-related terms (G2/M transition, chromosome segregation, exit from mitosis) and genome maintenance (nucleotide-excision repair) along with SCF-ubiquitin\u2013proteasome\u2013dependent protein degradation, pointing to a cluster of proteins coordinating cell-cycle progression with DNA repair and protein turnover.","confidence":"High","size":25,"edges":299,"triangles":2277,"max_degree":24,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0000086","count":25},{"id":"GO:0007059","count":25},{"id":"GO:0016032","count":25},{"id":"GO:0031146","count":25},{"id":"GO:0070911","count":25}]},{"hash":"1532681564459676965","title":"mRNA splicing and translation initiation","description":"The cluster is enriched for spliceosome-mediated mRNA splicing, regulation of splicing, mRNA modification and stability, and assembly of the translation initiation machinery (preinitiation complex, eIF4F complex). This suggests proteins involved in post-transcriptional RNA processing and preparing mRNA for translation.","confidence":"High","size":25,"edges":293,"triangles":2144,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":18},{"id":"GO:0045292","count":17},{"id":"GO:0010610","count":16},{"id":"GO:1901407","count":15},{"id":"GO:0048026","count":15}]},{"hash":"2229760244775491995","title":"Signaling Pathway Regulators","description":"The top terms center on various signaling pathways (GPCR signaling, IGF receptor signaling, thrombin receptor signaling) and signaling regulation (Rho/Ral pathways), with additional immune activation and cell spreading facets, suggesting a general role in modulating diverse signal transduction processes rather than a single specific function. A few terms relate more to structural or developmental aspects, but the common thread is involvement in signaling cascades. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0048009","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0051262","count":4},{"id":"GO:0002291","count":4}]},{"hash":"1756354413699146097","title":"Nuclear import and NPC assembly","description":"The GO terms are dominated by nuclear import into the nucleus and nuclear pore complex assembly, with related terms on ribosomal protein import and NLS-bearing proteins, indicating a cluster of proteins centered on nucleocytoplasmic transport and NPC biogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":12},{"id":"GO:0043547","count":12},{"id":"GO:0042176","count":10},{"id":"GO:0006610","count":10},{"id":"GO:0000060","count":10}]},{"hash":"1342950743932202533","title":"ER Protein Folding and Redox Homeostasis","description":"The cluster centers on protein quality control in the endoplasmic reticulum and redox balance: multiple terms point to ER-assisted folding, unfolded protein response, chaperone activity, and detoxification under oxidative stress. A viral process and transcription term appear less central, likely incidental. Overall, the group seems to represent ER folding machinery coupled with oxidative stress response.","confidence":"High","size":25,"edges":66,"triangles":97,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":10},{"id":"GO:0034975","count":10},{"id":"GO:0070301","count":8},{"id":"GO:0016032","count":8},{"id":"GO:0070389","count":7}]},{"hash":"2243709581220923304","title":"Ubiquitin-Dependent Immune Signaling","description":"This cluster's terms point to ubiquitination as a central process (ubiquitin-dependent degradation, polyubiquitination, and K6-linked ubiquitination) and to innate immune and antiviral signaling (innate immune response, defense against virus, NF-kappaB and TNF signaling), suggesting a cohesive role in ubiquitin-regulated immune responses.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0051865","count":11},{"id":"GO:0045087","count":9},{"id":"GO:0051607","count":9},{"id":"GO:0007026","count":8}]},{"hash":"161932450450983075","title":"Mitochondrial dynamics and autophagy","description":"Based on the prominent GO terms, the cluster is enriched for mitochondrial membrane fission and regulation of membrane potential, along with macroautophagy, pointing to mitochondrial maintenance and quality control. Other membrane trafficking terms (ER fusion, Golgi retention) suggest broader organelle membrane remodeling and signaling tied to cellular metabolism and division, making a theme of mitochondrial dynamics with interconnected organelle trafficking. ","confidence":"Medium","size":25,"edges":25,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0090149","count":5},{"id":"GO:0000002","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0051881","count":4}]},{"hash":"282869933774839719","title":"Ocular and craniofacial development","description":"The top GO terms cluster around eye development (lens differentiation, camera-type eye development, visual perception) and craniofacial morphogenesis (neural crest cell migration, palate/roof of mouth, odontogenesis). These point to embryonic patterning and development of sensory structures and facial features, likely sharing regulatory programs such as transcriptional control. Some terms also touch on broader organ morphogenesis (e.g., ureteric bud formation), but the dominant signal is ocular and craniofacial development.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0001755","count":8},{"id":"GO:0060021","count":8},{"id":"GO:0030901","count":8},{"id":"GO:0042475","count":7}]},{"hash":"1539892360774794618","title":"Complement and Coagulation in Craniofacial Biomineralization","description":"The top GO terms show immune/hemostatic processes (complement activation, blood coagulation) alongside development-related terms (roof of mouth development, biomineral tissue development, angiogenesis). This suggests proteins involved in craniofacial morphogenesis with vascular and immune components, with transcription terms reflecting broader regulatory activity during development.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0007596","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0000122","count":5}]},{"hash":"479276441640035501","title":"Complement activation and coagulation proteins","description":"This cluster is dominated by GO terms for complement activation (classical and lectin pathways) and blood coagulation, indicating proteins involved in innate immunity and hemostasis. While a few other terms (collagen catabolic process, endodermal differentiation, lens fiber differentiation, and others) appear, they are less central to the core theme. Overall, the proteins most likely function together in the complement-coagulation axis. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0030574","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0014068","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1444152577996191775","title":"Cytoskeletal remodeling and cell migration in angiogenesis","description":"The top GO terms cluster around actin cytoskeleton dynamics (actin filament severing, lamellipodium assembly, Rho signaling) and processes involving cell movement and neurite development, with angiogenesis and megakaryocyte development pointing to vascular/hematopoietic contexts. This suggests proteins that regulate cytoskeletal remodeling to drive migration and shape changes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035855","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0014068","count":5}]},{"hash":"336460611364679486","title":"Unknown","description":"The GO terms cover disparate processes ( adipocyte/foam cell differentiation, immune signaling, apoptosis, mRNA stability, vascular remodeling, and proteasome assembly ) with no clear single function tying the 25 proteins together, so a cohesive label is not supported.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0010745","count":10},{"id":"GO:0045444","count":10},{"id":"GO:0009409","count":9},{"id":"GO:0070427","count":9},{"id":"GO:0097284","count":9}]},{"hash":"829657854488330201","title":"Adrenergic Cardiovascular Signaling","description":"These proteins cluster around adrenergic signaling and cardiovascular regulation, with key terms like MAPK-activating adrenergic receptor signaling and positive regulation of heart rate by epinephrine/norepinephrine, plus dopaminergic synaptic transmission. The presence of platelet activation and xenobiotic response terms suggests broader systemic coordination by sympathetic/neuroendocrine pathways. Overall, the core theme appears to be adrenergic-driven control of cardiovascular and neural processes. ","confidence":"High","size":25,"edges":297,"triangles":2232,"max_degree":24,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030168","count":20},{"id":"GO:0001963","count":19},{"id":"GO:0071883","count":19},{"id":"GO:0001996","count":19},{"id":"GO:0048609","count":19}]},{"hash":"1947369154660307626","title":"Neural development and differentiation","description":"The dominant GO terms center on neural lineage development, including forebrain development, cerebellar granule cell differentiation, and oligodendrocyte differentiation, alongside general development and transcriptional regulation. While there are a few broader terms (e.g., skeletal development, protein ubiquitination), the neural differentiation signals are strongest and most representative of the cluster\u2019s function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0016567","count":6},{"id":"GO:0001501","count":6},{"id":"GO:0030900","count":6},{"id":"GO:0070059","count":6}]},{"hash":"2097630867953726857","title":"Neuronal development and SNARE-mediated exocytosis","description":"This cluster centers on nervous system development and regulation of secretion/neuronal signaling. GO terms point to neural differentiation and neuronal migration (nervous system development; GnRH neuronal migration to hypothalamus), along with mechanisms of secretion (calcium-dependent exocytosis) and regulation of the SNARE machinery, which underlie neurotransmitter release. The inclusion of insulin secretion and protein oligomerization may reflect neuroendocrine and general protein interaction components linked to secretion processes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0014912","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0045956","count":2}]},{"hash":"1474259065546500136","title":"Nervous system development and synapse formation","description":"Most of the top GO terms cluster around neural development and synaptic connectivity (nervous system development, neuron migration, positive regulation of synapse assembly, synapse assembly, ERK signaling). There are some additional developmental and extracellular matrix terms (collagen fibril organization, roof of mouth development) that can co-occur with neural development, and a few immune-related complements terms that appear less central. Overall, the dominant theme is nervous system development and synaptic organization.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0007399","count":4}]},{"hash":"710060550349132288","title":"Chromatin remodeling and transcription regulation","description":"The top GO terms cluster around chromatin remodeling and transcription control (GO:0043044; GO:0006357), with supporting histone modification hints (GO:0034720, GO:0043983, GO:0043982) though some are obsolete, suggesting an epigenetic regulation theme. A few terms reference metabolism or signaling, but the dominant pattern points to nuclear chromatin dynamics governing gene expression.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010890","count":2},{"id":"GO:0090043","count":2},{"id":"GO:0031496","count":2},{"id":"GO:0034720","count":2},{"id":"GO:0043044","count":2}]},{"hash":"485290471845385166","title":"Embryogenesis and organogenesis","description":"This cluster\u2019s top GO terms cluster around developmental processes and tissue differentiation: adaptive immune response is present but the predominant themes are embryonic system development, left-right patterning, endocardial cushion EMT, placental/placental-related development, cartilage morphogenesis, and endocrine system formation. These together point to a cohesive theme of embryonic development and organogenesis, with a few outliers that may reflect broader or species-specific roles. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1377378492932790641","title":"Apoptosis and Cell Cycle Regulation","description":"The terms cluster around control of cell fate, including negative regulation of cell proliferation, various apoptotic processes, TNF signaling, and cell cycle transitions (G1/S) and cytokinesis, with some developmental context (ossification, mammary involution) and PARP-related signaling; the common theme is modulation of survival and division rather than a single specific pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":4},{"id":"GO:0097284","count":3},{"id":"GO:0071356","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0030279","count":3}]},{"hash":"637742728917624181","title":"Innate Immune Signaling and Bone Remodeling","description":"The most represented terms point to innate immune responses (TLR/MyD88, NF-kB/I-kappaB phosphorylation, IL-18) and tissue remodeling components (bone development, collagen fibril organization). There is also regulation of metabolism-related signaling (CAMKK-AMPK) and branching morphogenesis of nerves, suggesting broader developmental signaling cross-talk. Taken together, the cluster seems to group proteins involved in inflammatory signaling that interfaces with bone extracellular matrix remodeling and development. Hence the chosen label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0060348","count":9},{"id":"GO:0030199","count":7},{"id":"GO:1905289","count":6},{"id":"GO:2000172","count":6}]},{"hash":"2015126091748273065","title":"Ribosome biogenesis and rRNA maturation","description":"This cluster is enriched for GO terms centered on ribosomal RNA maturation (LSU and 5.8S), ribosomal large subunit biogenesis, and RNA processing activities (RNA methylation, mRNA transport). The presence of mitotic cell cycle and development terms suggests roles in cell growth, but the strongest signals are ribosome assembly and rRNA maturation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:0036265","count":6},{"id":"GO:0051028","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0043547","count":5}]},{"hash":"216280166285325182","title":"Eye development and morphogenesis","description":"This cluster is strongly enriched for eye-related terms (retina development, camera-type eye development, embryonic eye morphogenesis) along with broader developmental processes and transcriptional regulation, suggesting a network of factors driving ocular morphogenesis and related organ development.","confidence":"High","size":24,"edges":184,"triangles":611,"max_degree":21,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":10},{"id":"GO:0007275","count":10},{"id":"GO:0000122","count":9},{"id":"GO:0006366","count":9},{"id":"GO:0060041","count":9}]},{"hash":"888038990340009568","title":"Developmental transcriptional regulation and organ morphogenesis","description":"This cluster centers on transcriptional control (DNA-templated transcription and chromatin remodeling) and includes multiple organ morphogenesis terms (ear, pancreas, muscle, lung, trachea, ureteric bud, digestive tract), suggesting a broad role in regulating gene expression to drive developmental tissue morphogenesis.","confidence":"Medium","size":24,"edges":150,"triangles":422,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0000122","count":12},{"id":"GO:0048752","count":8},{"id":"GO:0031018","count":7},{"id":"GO:0035914","count":7}]},{"hash":"1924561527956863487","title":"Ribosome biogenesis and translation","description":"This cluster is strongly enriched for translation-related terms (GO:0006412) and ribosome biogenesis, including maturation of SSU-rRNA and biogenesis of ribosomal subunits, pointing to proteins involved in ribosome assembly and protein synthesis. Some transcription- and DNA damage\u2013response terms are present but secondary, so the core theme is ribosome formation and translation.","confidence":"High","size":24,"edges":263,"triangles":1771,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":19},{"id":"GO:0000462","count":8},{"id":"GO:0042254","count":6},{"id":"GO:0042273","count":4},{"id":"GO:0031564","count":4}]},{"hash":"1853379132717493681","title":"Global translation apparatus and mRNA decay","description":"The top GO terms cluster around translation at multiple levels (cytoplasmic and mitochondrial), including initiation, elongation, termination, and fidelity, plus selenocysteine incorporation. They also include a deadenylation-dependent mRNA decay term, linking protein synthesis to mRNA turnover; a miscellaneous RNA silencing term appears minor in comparison. Together these terms indicate the proteins function primarily in translation and related RNA processing.","confidence":"High","size":24,"edges":99,"triangles":294,"max_degree":14,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0046677","count":10},{"id":"GO:0070125","count":8},{"id":"GO:2000767","count":8},{"id":"GO:0002184","count":8}]},{"hash":"2001278950149301779","title":"Mitochondrial translation and respiratory chain assembly","description":"The cluster is strongly enriched for mitochondrial-centric processes: mitochondrial translation, protein import into the mitochondrial matrix, and components of the mitochondrial electron transport chain, including complex I assembly and oxidative phosphorylation. While a few terms are obsolete, the dominant pattern points to mitochondrial gene expression and respiration.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":3},{"id":"GO:0032981","count":3},{"id":"GO:0032543","count":2},{"id":"GO:0097428","count":2},{"id":"GO:0006412","count":2}]},{"hash":"1400250750820523045","title":"Hormone-regulated transcription and cell cycle control","description":"This cluster centers on DNA-templated transcription and robust cell cycle regulation (G1/S transition, CDK activity, chromosome condensation via H3-S10), suggesting core transcriptional programs that govern proliferation. The presence of Leydig cell differentiation and mammary gland development terms points to hormone-responsive developmental contexts, complemented by leptin response and galactose transcription regulation, indicating tissue- and metabolism-linked regulation of these programs. An ER unfolded protein response signal is also present, which can accompany secretory cell development. Overall, the dominant theme is transcriptional control linked to hormone-influenced development and cell cycle progression.","confidence":"High","size":24,"edges":13,"triangles":1,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":22},{"id":"GO:0033327","count":19},{"id":"GO:0060749","count":19},{"id":"GO:0030968","count":17},{"id":"GO:0000082","count":17}]},{"hash":"1101097678282077554","title":"Neural and cardiac development signaling","description":"The top GO terms cluster around developmental processes, especially heart development and nervous system development, with related signaling (Rho/Rho-mediated signaling, Hedgehog/SMO pathway) and cell adhesion, suggesting a cohesive theme of signaling pathways guiding neural and cardiac tissue development. Some terms (symbiont entry, macrophage activation) are less central and may reflect broader signaling contexts, but the dominant signal is developmental signaling in neural and cardiac contexts.","confidence":"Medium","size":24,"edges":20,"triangles":7,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":15},{"id":"GO:0061000","count":14},{"id":"GO:0007507","count":14},{"id":"GO:0043552","count":13},{"id":"GO:0007399","count":12}]},{"hash":"723216119485773179","title":"Immune signaling and development regulation","description":"The top GO terms cluster around immune-related processes (neutrophil clearance, positive regulation of IL-1\u03b2 production, positive regulation of dendritic cell differentiation) and signaling pathway modulation (TGF-\u03b2 stimulus response, Wnt signaling). There are also development-related terms (cornea development, peripheral nervous system development). This pattern suggests proteins that coordinate immune signaling with developmental regulation, justifying the label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097350","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0071560","count":6},{"id":"GO:0045819","count":5},{"id":"GO:0090090","count":5}]},{"hash":"891070193584740844","title":"Motor Neuron Development and Axon Guidance","description":"The GO terms cluster around nervous system development, especially motor neuron axon growth and guidance (axonogenesis, motor neuron axon guidance, lateral motor column migration) and associated cell-matrix adhesion, suggesting a cohesive program for motor neuron development and pathfinding. Some terms reflect broader vertebrate development (somite specification, inner ear development), while one term (lipopolysaccharide biosynthetic process) seems unrelated noise.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0048936","count":5},{"id":"GO:0008045","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0009103","count":5}]},{"hash":"385802071972178504","title":"Eye development and morphogenesis","description":"This cluster is enriched for embryonic development with a strong emphasis on eye formation (camera-type eye development, embryonic eye morphogenesis) and related morphogenesis processes. The transcription-related terms (transcription by RNA polymerase II, negative regulation of transcription) suggest regulation of developmental programs, aligning with organogenesis. Additional terms like neural crest cell migration and branching morphogenesis reflect broader embryonic morphogenesis, but the dominant signal centers on eye development.","confidence":"High","size":24,"edges":124,"triangles":139,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0048048","count":13},{"id":"GO:0060441","count":12},{"id":"GO:0043010","count":12},{"id":"GO:0000122","count":11}]},{"hash":"1132727943778908559","title":"SNARE-mediated synaptic vesicle exocytosis and plasticity","description":"This cluster is dominated by terms centered on synaptic vesicle docking/fusion and calcium-regulated exocytosis (SNARE complex assembly, vesicle fusion to presynaptic membrane, calcium-regulated neurotransmitter release) and on synaptic plasticity (short-term regulation and long-term memory). The presence of growth hormone and histamine secretion terms also aligns with neuroendocrine/neurotransmitter release aspects. Overall, the proteins appear focused on neuronal communication and plasticity, justifying a label around synaptic vesicle exocytosis and plasticity.","confidence":"High","size":24,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035493","count":6},{"id":"GO:0031915","count":6},{"id":"GO:0031629","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0099590","count":5}]},{"hash":"314577864124340267","title":"Nuclear mRNA splicing and export regulators","description":"This cluster centers on RNA processing in the nucleus, with multiple GO terms for spliceosome-mediated splicing, mRNA export, and regulation of translation initiation, plus ncRNA-mediated gene silencing. A few terms touch on DNA replication or obsolete polyadenylation annotations, but the core signal is regulation of mRNA processing and export.","confidence":"Medium","size":24,"edges":27,"triangles":18,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":8},{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0006406","count":7},{"id":"GO:0006260","count":6}]},{"hash":"1706974441496612463","title":"Organogenesis and neural differentiation","description":"This cluster is enriched for terms spanning retina and inner ear morphogenesis, osteoblast and thyroid gland development, neuronal commitment, and regulation of transcription, indicating a broad developmental program with a strong emphasis on neural differentiation and gene expression control across multiple tissues.","confidence":"Medium","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":14},{"id":"GO:0006366","count":14},{"id":"GO:0002076","count":11},{"id":"GO:0002087","count":11},{"id":"GO:2000288","count":10}]},{"hash":"1165974733753249859","title":"mRNA processing and translation initiation","description":"The proteins are enriched for mRNA splicing, export, and maturation terms as well as translation preinitiation complex assembly, suggesting a coordinated role in mRNA maturation and the initiation of protein synthesis.","confidence":"High","size":24,"edges":274,"triangles":1980,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":21},{"id":"GO:0006406","count":19},{"id":"GO:0000381","count":19},{"id":"GO:0045292","count":19},{"id":"GO:0006378","count":19}]},{"hash":"1744453814572002472","title":"Ubiquitin-Dependent Protein Degradation and Signaling","description":"This cluster is dominated by ubiquitination-related processes: ubiquitin-dependent protein catabolic process, protein autoubiquitination, various polyubiquitinations (including K63- and K6-linked), and regulation of NF-kappaB signaling and TNF pathways. The presence of histone catabolic and circadian rhythm regulation terms also ties into ubiquitin-mediated control of chromatin and clock proteins. Together, these terms describe a cohesive theme of ubiquitin-driven protein turnover and consequent signaling roles.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:1903265","count":9},{"id":"GO:0051865","count":9},{"id":"GO:0042752","count":9},{"id":"GO:0036205","count":8}]},{"hash":"1840368883940525975","title":"Ubiquitin-Driven Innate Immunity and NF-kappaB Signaling","description":"The top GO terms indicate a strong emphasis on ubiquitination processes (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, K6-linked ubiquitination) and NF-kappaB pathway regulation (NF-kappaB transcription factor activity, I-kappaB phosphorylation), alongside innate immune response. This suggests a coherent cluster centered on how ubiquitin signaling modulates innate immunity and NF-\u03baB signaling, with some historical/obsolescent terms present but not changing the overall theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0051092","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0051865","count":11},{"id":"GO:0016567","count":10}]},{"hash":"1824945841659343042","title":"Neural development and synaptic signaling","description":"The top GO terms are dominated by nervous system development and regulation of synaptic vesicle exocytosis, with supporting roles for ERK signaling and mechanosensory responses, pointing to neuronal signaling and synaptic function as the core theme. While there are other developmental processes present (e.g., hair follicle morphogenesis), the prominent focus on neural development and vesicle trafficking supports this label.","confidence":"Medium","size":24,"edges":77,"triangles":23,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0006893","count":6},{"id":"GO:0071260","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0031384","count":5}]},{"hash":"1482522304218972505","title":"Neuronal development and axon organization","description":"The top GO terms cluster around nervous system development, axonal structure and signaling, including paranode localization and clustering of voltage-gated sodium channels, along with Hedgehog (Smoothened) pathway signaling, cytoskeletal remodeling via GTPases, and associated endocytosis/phagocytosis processes. This suggests a cohesive theme of neuronal development and maintenance of axon morphology and function rather than a generic cellular process. ","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:1900026","count":6},{"id":"GO:0007224","count":5},{"id":"GO:0051496","count":5},{"id":"GO:0043547","count":5}]},{"hash":"951328992253374363","title":"Rho/Ras GTPase signaling in cell migration and angiogenesis","description":"Explanation: The dominant terms center on regulation of Rho and Ras GTPase signaling, which govern cytoskeletal dynamics, vesicle trafficking, and cell movement. This is complemented by processes like neutrophil chemotaxis, extravasation, and angiogenesis/blood vessel remodeling. Some terms reflect vesicle exocytosis (acrosome reaction, vesicle priming), but they share the same signaling framework. Overall, the cluster appears to unify signaling control of cell migration and vascular remodeling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0007340","count":6},{"id":"GO:0043314","count":6},{"id":"GO:0016082","count":6},{"id":"GO:0060313","count":6}]},{"hash":"1689356402408405052","title":"Interferon-driven immune signaling and dendritic cell differentiation","description":"The cluster\u2019s top GO terms cluster around interferon signaling (type I and II), cytokine production (IL-12 and IL-2), dendritic cell differentiation, and regulation of TLR pathways, with a note on Th17 lineage commitment. Together they suggest a cohesive immune-activation module centered on interferon responses and antigen-presenting cell to T cell differentiation; a single outlier term on mammary gland epithelial differentiation is less connected to the main theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060333","count":2},{"id":"GO:0045084","count":2},{"id":"GO:0045351","count":2},{"id":"GO:0043011","count":2},{"id":"GO:0034127","count":2}]},{"hash":"287802381083152282","title":"Rho signaling and cytoskeleton dynamics","description":"These proteins are enriched for regulation of Rho signaling, a master driver of cytoskeletal remodeling. The top terms include actin cytoskeleton reorganization and centrosome localization, supporting a cytoskeletal focus. While there are also signals related to immune and neural processes (innate response, IL-2, synaptic depression) and barrier formation, the dominant theme is signaling pathways that converge on cytoskeletal dynamics across cell types, justifying the label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":8},{"id":"GO:0060292","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0090557","count":6},{"id":"GO:0007605","count":6}]},{"hash":"608493481214119469","title":"Endocytic trafficking and actin dynamics","description":"The terms point to vesicle uptake and transport (endocytosis, endosome to melanosome transport) and to actin-driven remodeling (filopodium assembly regulation, Rho signaling, centrosome maintenance). Ubiquitination and innate immune response terms further suggest regulation of signaling during membrane trafficking. Taken together, the cluster centers on endocytic/vesicular transport with cytoskeletal dynamics.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":4},{"id":"GO:0035646","count":3},{"id":"GO:1901998","count":3},{"id":"GO:0051661","count":3},{"id":"GO:0051489","count":3}]},{"hash":"352977630292469351","title":"Embryonic development and neural signaling","description":"The top GO terms cluster around broad developmental processes across tissues (multicellular organism development; skin, heart, cranial skeleton, palatal development) and include a neural activity term (long-term synaptic potentiation). While some transport terms appear, the predominant signal is embryonic development with a neural signaling component, justifying this combined label.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0007507","count":3}]},{"hash":"2185776359176951459","title":"Axon guidance and angiogenesis signaling","description":"This set centers on axon fasciculation/extension and guidance, with accompanying VEGF receptor and ERK signaling, plus Rho/GTPase\u2013mediated cytoskeletal dynamics and PI3K signaling. Together these terms point to coordinated neuronal pathfinding and vascular development signaling, with a smaller related immune/inflammatory cue. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0007413","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0090630","count":5}]},{"hash":"386385211615456122","title":"Neural signaling and sensory perception","description":"The top terms cluster around neuronal communication and sensory processing: detection of sound-related mechanical stimuli, excitatory postsynaptic potentials, multiple ion channels for Na+ and K+, and signaling pathways for GABA, dopamine, and acetylcholine, plus related behaviors (locomotion, taste aversion). This combination points to a cohesive theme of neural signaling and sensory perception rather than unrelated processes. Confidence: High","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":13},{"id":"GO:0060079","count":12},{"id":"GO:0071805","count":12},{"id":"GO:0035725","count":12},{"id":"GO:0001661","count":12}]},{"hash":"104132316351897254","title":"Embryonic development and organogenesis","description":"The top GO terms cover a broad set of developmental processes across tissues\u2014mesoderm formation, left-right patterning, palate, pharyngeal system, placental differentiation, cartilage morphogenesis, heart development (EMT in the endocardial cushion), and neural/system development. This points to a cohesive theme of embryogenesis and organogenesis rather than a single specific function, so a label like \u201cEmbryonic development and organogenesis\u201d is appropriate.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0060021","count":7},{"id":"GO:0060707","count":6},{"id":"GO:0060037","count":6},{"id":"GO:0048485","count":6}]},{"hash":"331010684623109536","title":"Synaptic signaling and plasticity","description":"The top GO terms cluster around neuronal signaling and synaptic regulation\u2014Rho/GTPase pathways, receptor clustering, dendritic spine morphogenesis, and long-term synaptic depression\u2014plus sensory/behavioral terms like vocalization and social behavior, pointing to neural communication and synaptic plasticity as the common theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071625","count":13},{"id":"GO:0007266","count":12},{"id":"GO:0070433","count":11},{"id":"GO:0090630","count":11},{"id":"GO:0043113","count":11}]},{"hash":"457240644605351036","title":"Synaptic signaling and cytoskeletal dynamics","description":"Top GO terms indicate neuronal signaling and sensory perception (sound and light detection) with regulation of short-term synaptic plasticity. The presence of actin cytoskeleton organization and small GTPase\u2013mediated signaling (Rho pathways) points to cytoskeletal remodeling accompanying signaling, a key feature of synaptic changes in neurons and sensory cells. IGF receptor signaling and growth-factor\u2013related responses provide additional signaling context but align with the neural/sensory theme. Overall, the cluster appears to comprise proteins involved in neuronal/sensory signal transduction coupled with cytoskeletal dynamics.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0050908","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0043314","count":3}]},{"hash":"1424906301113354127","title":"Mitochondrial Translation and Cristae Formation","description":"The cluster is dominated by GO terms tied to mitochondrial gene expression and inner-membrane architecture: mitochondrial translation and its positive regulation, cristae formation, and protein insertion into the mitochondrial membrane. This suggests a cohesive group of mitochondrial ribosome/translation machinery components and factors involved in inner-membrane biogenesis, with other terms like aging or stress responses likely reflecting broader cellular contexts rather than core function. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070131","count":3},{"id":"GO:0032543","count":3},{"id":"GO:0007568","count":2},{"id":"GO:0071356","count":2},{"id":"GO:0071320","count":2}]},{"hash":"1006573610486570765","title":"Paranodal and Juxtaparanodal Axon Junctions","description":"The GO terms point to localization and assembly of proteins at paranode and juxtaparanode regions of axons, including protein localization to paranode/juxtaparanode regions and paranodal junction assembly, as well as related adhesion and cytoskeletal dynamics (integrin activation and actin remodeling). While some terms touch broader developmental or signaling contexts, the strongest signal is a cohesive theme of axon\u2013glia junctions and regional axonal organization.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045765","count":4},{"id":"GO:0002175","count":4},{"id":"GO:0070306","count":4},{"id":"GO:2000249","count":4},{"id":"GO:0097067","count":4}]},{"hash":"2274865051465775628","title":"Embryonic development and morphogenesis","description":"The GO terms center on embryogenesis, organ and tissue formation, and morphogenesis across multiple lineages (mesoderm, neural crest, cartilage, pancreas, palate, placenta), including EMT events and left-right patterning. This suggests a broad developmental program rather than a single pathway, making \"Embryonic development and morphogenesis\" a representative label.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":9},{"id":"GO:0060021","count":8},{"id":"GO:0007498","count":7},{"id":"GO:0003198","count":6},{"id":"GO:0060707","count":6}]},{"hash":"2285680145119411915","title":"Broad Regulators of Signaling Pathways","description":"This cluster centers on GO terms that describe regulation of various signaling cascades, including CAMKK-AMPK, Wnt signalosome assembly, and MyD88-dependent TLR signaling, as well as regulatory roles in neuronal development and neurotransmitter signaling (e.g., neuron maturation and dopamine receptor signaling). The terms are diverse and there are no direct interaction edges, making it unlikely to assign a single precise function beyond \u201cregulation of signaling,\u201d hence the general label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905289","count":2},{"id":"GO:2000172","count":2},{"id":"GO:0035751","count":2},{"id":"GO:1904887","count":2},{"id":"GO:0002755","count":2}]},{"hash":"2121429196350632423","title":"Embryogenesis and organogenesis regulators","description":"GO terms point to broad regulatory roles in development and tissue formation rather than a single pathway. The terms cover embryonic growth, placental and endocrine tissue development, left-right patterning, cartilage morphogenesis, pancreatic cell lineage, and EMT-related heart development, suggesting a cluster of proteins involved in coordinating organogenesis and differentiation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:2000134","count":3},{"id":"GO:0033138","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060972","count":3}]},{"hash":"1691187513478501484","title":"Epigenetic DNA methylation and chromatin regulation","description":"Most prominent terms relate to DNA methylation and histone methylation (e.g., negative regulation of gene expression via DNA methylation; regulation of histone H3-K9 methylation). This suggests the proteins are involved in epigenetic regulation and chromatin state. Other terms appear less central (cGMP response, barrier regulation) but do not define the core theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":4},{"id":"GO:0043046","count":4},{"id":"GO:0071321","count":3},{"id":"GO:0090557","count":3},{"id":"GO:0019933","count":3}]},{"hash":"256698518459949324","title":"Membrane trafficking and ion transport","description":"Based on the top GO terms, the cluster centers on intracellular protein trafficking (ER exit, ER-to-Golgi transport, phospholipid translocation) and membrane/ion processes (potassium transport, maintenance of electrochemical gradients, membrane organization). The presence of terms related to tight junctions and junction development further suggests roles in cell\u2013cell junctions and barrier properties that are tied to membrane trafficking. Together, the proteins likely function in membrane trafficking coupled with ion homeostasis and junction formation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070863","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0045332","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0060857","count":2}]},{"hash":"2155467701040267136","title":"Cerebellar development and signaling","description":"The cluster shows strong enrichment for neural-development related terms such as cerebellar cortex formation and Bergmann glial cell differentiation, along with various signaling pathway regulations (ERK cascade, insulin receptor signaling, T cell signaling). While there are broader cell-cycle and regulatory terms present (kinetochore localization, CDK activity regulation), the neural development themes are prominent, suggesting a cohesive focus on cerebellar development coupled with signaling regulation.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":19},{"id":"GO:0045736","count":19},{"id":"GO:0048679","count":16},{"id":"GO:0021697","count":16},{"id":"GO:2001275","count":16}]},{"hash":"1889966410565428178","title":"Developmental and immune signaling regulators","description":"The cluster\u2019s top GO terms span neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration), immune signaling (T cell receptor signaling, leukocyte chemotaxis), and signaling-related processes (insulin signaling, kinase regulation, kinetochore localization). This mixture points to proteins that broadly regulate signaling pathways involved in development and immune responses, rather than a single specific function.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":23},{"id":"GO:0048679","count":23},{"id":"GO:0021697","count":23},{"id":"GO:2001275","count":23},{"id":"GO:0060020","count":23}]},{"hash":"1325177857904747384","title":"Centromere chromatin assembly and cell cycle control","description":"The cluster\u2019s top terms strongly point to nuclear processes governing chromosome organization and mitosis, especially CENP-A centromere chromatin assembly, DNA-templated transcription, cell division, and ubiquitin-mediated regulation. While other terms (ER-Golgi transport, stress responses) appear, the central theme is centromere/chromatin maintenance tied to cell cycle progression and protein turnover. ","confidence":"Medium","size":23,"edges":90,"triangles":149,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0000209","count":5},{"id":"GO:0061641","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0071560","count":5}]},{"hash":"983239651393422621","title":"DNA replication and cell cycle machinery","description":"Explanation: The most frequent terms pertain to cell division, DNA replication, and centromeric chromatin assembly (CENP-A), pointing to core cell-cycle and replication processes. Additional terms about ribosome biogenesis and cytoplasmic translation align with growth and protein synthesis required during proliferation, while vesicle transport and DNA damage\u2013response terms provide supporting context but do not override the central theme. Confidence: Medium","confidence":"","size":23,"edges":7,"triangles":2,"max_degree":3,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0002181","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0061641","count":2}]},{"hash":"90925886306509478","title":"Glycinergic Neurotransmission and Glycine Transport","description":"Based on the Top Terms, the cluster is driven by glycine-related synaptic functions (glycine secretion, import, and regulation of glycinergic transmission) and glycinergic synaptic signaling, indicating a coherent theme around glycine-mediated neurotransmission. Additional terms point to broader neurotransmitter metabolism (dopamine, serotonin) and CNS development aspects (perineurial glial growth, thalamus development), suggesting the cluster centers on glycine handling within nervous system signaling. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0042066","count":9},{"id":"GO:0060012","count":9},{"id":"GO:0042420","count":9},{"id":"GO:0061537","count":9},{"id":"GO:0021794","count":9}]},{"hash":"1666586205858000623","title":"Energy metabolism and organelle stress response","description":"This cluster centers on core metabolic processes (PRPP biosynthesis; glycogen and alpha-glucan catabolism) paired with organelle stress pathways (ER unfolded protein response; mitochondrial complex IV assembly; regulation of cytochrome c release) and cell fate signals (necroptosis, translation, and cell division). The mix suggests a theme around energy production and the cellular stress responses of ER and mitochondria that influence survival or death, rather than a single, narrowly defined pathway. The viral genome replication term is less central and may reflect host-virus interaction annotations rather than a defining feature of the cluster.","confidence":"Medium","size":23,"edges":12,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006015","count":4},{"id":"GO:0005980","count":3},{"id":"GO:0030980","count":3},{"id":"GO:0070266","count":3},{"id":"GO:0051301","count":2}]},{"hash":"1003010863192033281","title":"Mitochondrial Translation and Respiration with Nucleotide Metabolism","description":"The top GO terms cluster around mitochondrial translation (protein synthesis within mitochondria), components of the electron transport chain (NADH to ubiquinone) and aerobic respiration, and iron-sulfur cluster assembly, all indicative of mitochondrial energy production. Added nucleotide biosynthesis and salvage terms suggest concurrent nucleotide metabolism. Together these point to a cluster centered on mitochondrial-like energy metabolism with supporting nucleotide metabolism, rather than a single narrow function.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006120","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0009399","count":2},{"id":"GO:0016226","count":2}]},{"hash":"303960327083132683","title":"Lipid Metabolism and Detoxification","description":"GO terms converge on lipid metabolism and transport, plus oxidative/detoxification responses, suggesting proteins that participate in lipid remodeling and related detox pathways.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0045903","count":2},{"id":"GO:0070292","count":2},{"id":"GO:0046485","count":2}]},{"hash":"685666757654952222","title":"RNA processing and translation factors","description":"The top GO terms cluster around RNA maturation (splicing, polyadenylation, methylation) and translation initiation/reinitiation, with additional transcription and cell-cycle-related terms. Together they suggest a gene-expression\u2013focused module spanning RNA processing and protein synthesis control, rather than a single enzymatic activity. This makes the label a concise, coherent summary of the cluster\u2019s functions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001731","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0006378","count":6},{"id":"GO:0060733","count":6}]},{"hash":"1242504060510994732","title":"Motor neuron differentiation and neuromuscular synapse assembly","description":"The cluster is dominated by GO terms tied to neural development and neuromuscular function: somatic motor neuron differentiation, neurofilament cytoskeleton organization, neuromuscular process controlling posture, and positive regulation of synapse assembly. Additional terms involving cellular growth and responses to mechanical stimuli, plus Schwann cell migration, support a nervous-system/muscle context and myelination environment. Collectively, these proteins appear to be involved in motor neuron development and the formation or maintenance of neuromuscular junctions.","confidence":"Medium","size":23,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0071260","count":2}]},{"hash":"2230741730625978759","title":"Ion Transport and pH Homeostasis","description":"The top GO terms cluster around transporter and ion/homeostasis processes (bicarbonate transport, chloride transport, oxalate transport, and intracellular pH elevation), suggesting proteins involved in maintaining ionic balance and pH. Additional regulatory themes (regulation of transcription, GTPase activity) may reflect signaling that modulates transport; a few terms appear organism-specific and less central, but the core signal is transport and pH regulation.","confidence":"Medium","size":23,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":4},{"id":"GO:0071383","count":3},{"id":"GO:0043547","count":3},{"id":"GO:1903833","count":3},{"id":"GO:0015701","count":3}]},{"hash":"467497202855162385","title":"Core metabolism and biosynthesis","description":"The cluster shows a convergence on central metabolic and biosynthetic processes: canonical glycolysis, heme (protoporphyrinogen IX) biosynthesis, and key cofactor biosynthesis like biotin and menaquinone, along with various catabolic pathways and cell wall-related organization. Some terms such as Notch signaling and insulin response appear as outliers or annotation noise, but the dominant theme is metabolism and macromolecule synthesis.","confidence":"Medium","size":23,"edges":214,"triangles":1149,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007219","count":9},{"id":"GO:0042853","count":9},{"id":"GO:0097053","count":9},{"id":"GO:0009234","count":7},{"id":"GO:0071555","count":7}]},{"hash":"1013594633006685142","title":"Neural lipid biosynthesis and Golgi trafficking","description":"This cluster combines fatty acid elongation and very long-chain fatty acid biosynthesis with Golgi-related transport processes (Golgi to endosome/plasma membrane/localization to Golgi), plus neural development signals such as dendritic spine morphogenesis and cortical patterning. The convergence suggests roles in membrane lipid production and Golgi-mediated trafficking that support neuronal maturation and synapse formation, though the links are broad and not highly specific in the data provided.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":2},{"id":"GO:0042761","count":2},{"id":"GO:0061370","count":2},{"id":"GO:0030497","count":2},{"id":"GO:0006895","count":1}]},{"hash":"1965689036495965800","title":"Neural development and axon guidance","description":"This cluster centers on nervous system development, neurogenesis, and axon guidance signaling (hedgehog/Smo, Roundabout/Robo), with related terms like interneuron migration chemorepulsion and paranode axon localization. The convergence of these neural development and axon guidance terms indicates a coherent theme of neuronal growth, migration, and axon pathfinding, supported by signaling pathways such as STAT phosphorylation. ","confidence":"High","size":23,"edges":191,"triangles":841,"max_degree":22,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042517","count":16},{"id":"GO:0007399","count":14},{"id":"GO:0007224","count":14},{"id":"GO:0035385","count":14},{"id":"GO:0070106","count":14}]},{"hash":"713981099737061093","title":"RNA metabolism and nuclear-cytoplasmic transport","description":"The cluster is enriched for RNA-related processes: mRNA tail shortening, mRNA stability and localization (including oskar mRNA), regulatory ncRNA-mediated silencing, and mRNA export, plus transcription. Additional terms touch on DNA repair, cell cycle, and ubiquitin-mediated degradation, indicating broader cellular regulation but the dominant theme centers on RNA processing, regulation, and nucleo-cytoplasmic flow, with some quality-control pathways (ribophagy). Confidence reflects a coherent RNA-centric theme with some peripheral processes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0060213","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0045451","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006281","count":2}]},{"hash":"1738420479926519925","title":"Actin Dynamics and Cell Adhesion Signaling","description":"The cluster is enriched for actin cytoskeleton\u2013related processes (microspike assembly, actin reorganization), Rho GTPase signaling, and regulation of cell spreading/adhesion, with supporting signals from PI3K/insulin pathways and developmental context (heart development). This points to a cohesive theme of cytoskeletal remodeling driving cell movement and morphogenesis.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":6},{"id":"GO:0030035","count":5},{"id":"GO:0031532","count":5},{"id":"GO:0010765","count":5},{"id":"GO:0008286","count":5}]},{"hash":"1224414401907669458","title":"Ubiquitin-Mediated Muscle and Circadian Regulation","description":"Based on the Top Terms, ubiquitin-dependent protein catabolic process and K33-linked ubiquitination are dominant, indicating a module centered on targeted protein degradation. Co-occurring terms emphasize muscle biology (skeletal muscle development, sarcomere organization) and circadian rhythm regulation, suggesting a link between protein turnover and muscle/circadian control. Some outliers (brassinosteroid signaling, distal tubule morphogenesis, chromosome passenger complex localization) may reflect broader, conserved roles of ubiquitination rather than a strictly muscle-centric function. Overall, the cluster appears to reflect ubiquitin-mediated regulation with a muscle and circadian emphasis.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0042752","count":14},{"id":"GO:0036268","count":11},{"id":"GO:0035853","count":11},{"id":"GO:0051260","count":11}]},{"hash":"2274082959942654324","title":"Ubiquitin-Dependent NF-kappaB/TNF Signaling Regulation","description":"The cluster is dominated by ubiquitin-related processes and inflammatory signaling terms: ubiquitin-dependent proteolysis, NF-kappaB activation, TNF signaling, I-kappaB phosphorylation, JNK regulation, and K6-linked ubiquitination. This pattern points to a coordinated regulatory module controlling inflammatory and stress-responsive signaling via ubiquitination.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:2000620","count":8},{"id":"GO:0085020","count":8},{"id":"GO:1903721","count":8},{"id":"GO:0009048","count":8}]},{"hash":"1936266007368494554","title":"Embryonic organogenesis across multiple tissues","description":"The top GO terms point to development across diverse tissues\u2014pituitary, eye, inner ear, teeth, hindlimb, kidney, and peripheral nervous system\u2014with primitive streak formation indicating early embryogenesis. This suggests the proteins are involved in broad organogenesis rather than a single pathway, hence a general embryonic development label.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":9},{"id":"GO:0043010","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0048839","count":9},{"id":"GO:0007601","count":8}]},{"hash":"1687161882419789879","title":"Embryonic organogenesis and morphogenesis","description":"The Top Terms are dominated by developmental and morphogenetic processes across multiple tissues (pancreas development, heart development, cartilage morphogenesis, placenta/embryonic development, pattern formation, EMT in heart-related cushions, roof of the mouth). This points to a cohesive theme of embryonic development and organ formation rather than a single pathway, so a label focusing on embryonic organogenesis best captures the cluster. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0060806","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0060536","count":6}]},{"hash":"832197011262966425","title":"Embryonic organ development and morphogenesis","description":"The protein set shows broad embryonic development roles across organs (pancreatic cell development, placental patterning, left-right pattern formation, cartilage and palate morphogenesis, endocardial cushion EMT, trophoblast differentiation, endocrine system development) with some differentiation regulation and coagulation. This suggests a general theme of embryonic organ development and tissue morphogenesis rather than a single pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":8},{"id":"GO:0060806","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0003198","count":6}]},{"hash":"29965149807511857","title":"Auditory mechanosensation and neural excitability","description":"The cluster is enriched for terms tied to sound perception, detection of mechanical stimuli, excitatory postsynaptic potentials, and membrane depolarization, plus ion transport, pointing to neurons and mechanosensory auditory signaling. Heterophilic adhesion and smooth septate junction components may reflect synaptic organization or epithelial mechanosensory structures common in invertebrates. Overall, it represents neurosensory signaling in auditory pathways.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0060079","count":8},{"id":"GO:0007157","count":7},{"id":"GO:0007605","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0035725","count":7}]},{"hash":"784150327432697121","title":"T cell activation and immune signaling","description":"This cluster centers on phagocytic recognition, T cell proliferation and co-stimulation, TCR-MHC interactions, CCR7 signaling, and detection of peptidoglycan, indicating a core theme of immune activation and communication between immune cells. A few terms about paranodal junctions and nerve impulse transmission appear less directly related, possibly due to multifunctional proteins or annotation overlap.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":8},{"id":"GO:0042102","count":8},{"id":"GO:0019226","count":8},{"id":"GO:0030913","count":8},{"id":"GO:0031295","count":8}]},{"hash":"1055417754829057955","title":"Organogenesis and tissue morphogenesis","description":"The proteins in this cluster map broadly to developmental and morphogenetic processes across multiple organ systems (lens, skeletal, nervous system, lung mesenchyme, salivary gland branching, organ induction), indicating a shared theme of organ/tissue formation rather than a single pathway.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":3},{"id":"GO:2000249","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0060445","count":3}]},{"hash":"1517037016550144557","title":"Adrenergic and dopaminergic GPCR signaling and thermoregulation","description":"Top GO terms point to GPCR-mediated signal transduction with adenylate cyclase activation (adrenergic pathways) and dopaminergic synaptic transmission, along with temperature-related processes (diet-induced thermogenesis, cellular response to temperature stimulus). The mix suggests neural/autonomic control of metabolism and body temperature, making this a coherent theme. ","confidence":"High","size":23,"edges":9,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":13},{"id":"GO:0019233","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0046541","count":12},{"id":"GO:0022900","count":11}]},{"hash":"1271997419624934912","title":"Adrenergic signaling and autonomic metabolic regulation","description":"The cluster is dominated by GO terms tied to sympathetic signaling and autonomic/metabolic responses (e.g., diet-induced thermogenesis, heart rate regulation by epinephrine, saliva secretion, temperature response, dopaminergic signaling, and MAPK-activating adrenergic pathways). Although a term like reproductive process is present, the prevailing pattern points to adrenergic/autonomic regulation of physiology and metabolism.","confidence":"High","size":23,"edges":175,"triangles":614,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":20},{"id":"GO:0046541","count":20},{"id":"GO:0018298","count":20},{"id":"GO:0019233","count":20},{"id":"GO:0042391","count":20}]},{"hash":"2012671858216518617","title":"Adrenergic GPCR Signaling and Heart Rate Regulation","description":"The cluster\u2019s top GO terms cluster around adrenergic GPCR pathways that activate adenylate cyclase and downstream MAPK signaling, plus physiological effects like increased heart rate and blood pressure. Dopaminergic and other neurotransmission terms are present, suggesting neural signaling involvement alongside cardiovascular regulation. Overall, the proteins likely participate in adrenergic receptor signaling and its cardiovascular/neural outcomes. ","confidence":"High","size":23,"edges":9,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":18},{"id":"GO:0007190","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0042493","count":13}]},{"hash":"1793802824250215620","title":"Adrenergic/Dopaminergic GPCR Signaling and Heart Regulation","description":"This cluster is driven by GO terms for GPCR signaling related to adrenergic and dopaminergic pathways, including activation of adenylate cyclase, MAPK signaling, and dopaminergic synaptic transmission, with clear links to cardiovascular regulation such as blood pressure and heart rate. While other terms like electron transport and xenobiotic response are present, the dominant theme points to GPCR-mediated signaling governing cardiovascular and neural functions.","confidence":"High","size":23,"edges":11,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":23},{"id":"GO:0007190","count":23},{"id":"GO:0010579","count":23},{"id":"GO:0045777","count":23},{"id":"GO:0001963","count":22}]},{"hash":"809105752489539085","title":"Embryonic organogenesis and morphogenesis","description":"Many GO terms in this cluster relate to development and shaping of organs (inner ear, eye, limb, palate, kidney basement membranes) during embryogenesis, with some involvement of transcriptional regulation and tissue remodeling. The common theme is broad developmental patterning and organ formation rather than a single pathway. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0051965","count":5},{"id":"GO:0007596","count":5}]},{"hash":"1857881822895434863","title":"GPCR-Mediated Pain and Thermogenesis Signaling","description":"The top terms point to GPCR signaling that activates adenylate cyclase, together with sensory perception of pain and cellular responses to temperature, plus diet-induced thermogenesis. This suggests a cohesive theme of GPCR-driven signaling underlying nociception and heat/metabolic regulation. Developmental and mitochondrial terms are present but appear less central to the core theme, which justifies a label centered on GPCR-pain-thermogenesis signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0010579","count":5},{"id":"GO:0007189","count":5},{"id":"GO:0002024","count":4}]},{"hash":"1640740831734803976","title":"Embryonic Development and Neural Adhesion","description":"The proteins in this cluster are enriched for broad embryonic development terms across multiple tissues (heart, skeletal system, angiogenesis) and include neural-specific processes (paranodal junction assembly, sodium channel clustering, nerve impulse transmission) alongside cell adhesion and cell migration terms. This suggests a developmental, morphogenesis-focused set with both neural and non-neural roles, rather than a single narrowly defined function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0001501","count":9},{"id":"GO:0030913","count":9},{"id":"GO:0007155","count":8},{"id":"GO:0045162","count":8}]},{"hash":"1374914836667567512","title":"Embryonic Development and Angiogenesis","description":"This cluster is dominated by GO terms tied to embryonic development and tissue formation\u2014in utero embryonic development, heart development, neuron projection development, and angiogenesis (and its regulation)\u2014plus related signaling (positive regulation of GTPase activity) and cell division, supporting a cohesive theme of developmental and vascular morphogenesis. Some terms (immunoglobulin production, response to amphetamine) may reflect multifunctional proteins or annotation noise.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0001975","count":3},{"id":"GO:0007507","count":3}]},{"hash":"415932205493612383","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070651","count":3},{"id":"GO:0000467","count":2},{"id":"GO:0070481","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0003197","count":2}]},{"hash":"1597972631718782664","title":"Host Immune Defense and Apoptosis","description":"This cluster is enriched for immune responses to bacteria (innate and adaptive), defense against infection, NK cell regulation, and apoptotic processes, suggesting a role in coordinating host defense and programmed cell death; a few outliers like lens fiber differentiation and nerve impulse may reflect annotation noise.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0042742","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0045953","count":4}]},{"hash":"1338595230372926742","title":"Epithelial Polarity and Junction Assembly","description":"The majority of GO terms in this cluster center on establishing and organizing the apical/basal polarity of epithelial cells (establishment of epithelial cell apical/basal polarity, bicellular tight junction assembly, microvillus assembly, budding cell apical bud growth) as well as related cytoskeletal and centrosome localization processes (regulation of Rho signaling, establishment of centrosome localization). While a couple of terms reference neural processes, the dominant theme is epithelial cell polarity and surface structure formation, suggesting these proteins function in polarity and junction/microvillus assembly rather than a strictly neuronal role.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0051835","count":2},{"id":"GO:0007605","count":2}]},{"hash":"6312135653442380","title":"Immune activation and antibody production","description":"Top GO terms indicate cytokine regulation in inflammatory response, B cell apoptosis, immunoglobulin production, and granulocyte chemotaxis, with defense against viruses. These collectively point to immune system activation involving both humoral (antibody) and cellular responses and cytokine signaling, justifying a label that emphasizes immune activation and antibody production.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900017","count":3},{"id":"GO:0001783","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0043525","count":3}]},{"hash":"1419146180541019900","title":"TLR-NFkB innate immune signaling","description":"The top GO terms converge on Toll-like receptor signaling (MyD88-dependent), I-kappaB phosphorylation, and NF-\u03baB\u2013related pathways, with IL-18 production highlighting inflammatory output, indicating a cohesive innate immune signaling cluster. While a few neural development terms appear, they are secondary to the dominant immune signals, suggesting the core function is TLR-driven inflammatory signaling. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1905289","count":4},{"id":"GO:2000172","count":4},{"id":"GO:0032741","count":4},{"id":"GO:0035751","count":4},{"id":"GO:0046426","count":4}]},{"hash":"1087265879331643234","title":"Heart and sensory organ morphogenesis","description":"The top GO terms strongly point to developmental processes of the heart (outflow tract morphogenesis, ventricular septum morphogenesis, heart development) and sensory organs (inner ear development, lens development, sensory perception of sound, light stimulus detection), suggesting proteins in this cluster are linked to cardiovascular and sensory organ morphogenesis. A few terms like placenta development are present but do not override the dominant theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0007605","count":7},{"id":"GO:0014068","count":6},{"id":"GO:0050908","count":6},{"id":"GO:0003151","count":6},{"id":"GO:0060412","count":5}]},{"hash":"1817813116353396190","title":"Spliceosome and RNA Processing","description":"The top terms are dominated by RNA processing and splicing activities: mRNA cis splicing via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly, and tRNA processing, with additional related processes like histone mRNA metabolism and import into nucleus. These indicate a core functional theme of RNA maturation and spliceosome machinery. Some terms (e.g., response to water deprivation) are peripheral, but the prevailing signal strongly supports a spliceosome/RNA processing cluster.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":17},{"id":"GO:0006369","count":13},{"id":"GO:0000245","count":12},{"id":"GO:0009414","count":11},{"id":"GO:0051170","count":11}]},{"hash":"2264857222695837374","title":"Neurodevelopmental Signaling and Organogenesis Cluster","description":"Most terms center on nervous system development and neurogenesis, with angiogenesis and organ development (kidney/vagina) also represented, plus key signaling pathways (Smoothened/Hedgehog, Roundabout/Slit-Robo) and immune signaling (T cell receptor). This points to a cohesive theme of developmental signaling guiding neurodevelopment and organogenesis, with regulation of cell proliferation and apoptosis.","confidence":"Medium","size":22,"edges":226,"triangles":1443,"max_degree":21,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007399","count":15},{"id":"GO:0022008","count":14},{"id":"GO:0006915","count":14},{"id":"GO:0060068","count":14},{"id":"GO:0001525","count":14}]},{"hash":"956304609966290788","title":"Vertebrate organogenesis and metabolic pathways","description":"This cluster is enriched for developmental processes (kidney morphogenesis, paramesonephric duct development, neuron migration, cell-cell junction organization) alongside metabolic activities (retinol/retinal metabolism and testosterone/androgen biosynthesis). While platelet aggregation appears as a less coherent term, the dominant pattern points to vertebrate organogenesis coupled with hormonal and vitamin metabolism. Therefore the label reflects the main shared function of the proteins in this cluster.","confidence":"Medium","size":22,"edges":205,"triangles":1080,"max_degree":21,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0097477","count":8},{"id":"GO:0070527","count":8},{"id":"GO:0042574","count":7},{"id":"GO:0061370","count":7}]},{"hash":"1592093247482086340","title":"Developmental signaling and transcription regulation","description":"Top GO terms indicate signaling across systems (T cell receptor signaling, abscisic acid-activated signaling, phosphorylation regulation) combined with transcription (DNA-templated transcription) and diverse developmental processes (Schwann cell development, heart development, visual perception) as well as cell-cycle progression (G2/M transition). The shared theme is signaling-driven transcriptional control during development and growth, though terms span multiple species and contexts.","confidence":"Medium","size":22,"edges":28,"triangles":2,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":17},{"id":"GO:0009738","count":16},{"id":"GO:0006351","count":16},{"id":"GO:0000086","count":15},{"id":"GO:0014044","count":15}]},{"hash":"1936304821291699287","title":"Immune and tissue morphogenesis","description":"Top GO terms show immune activation (phagocytosis recognition, lectin pathway complement activation, platelet activation) alongside developmental morphogenesis (metanephric tubule development, lymph vessel morphogenesis, cartilage condensation), suggesting this cluster gathers proteins involved in inflammatory signaling that accompanies tissue remodeling across multiple organs.","confidence":"Medium","size":22,"edges":97,"triangles":233,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":22},{"id":"GO:0090238","count":15},{"id":"GO:0060355","count":15},{"id":"GO:0010572","count":15},{"id":"GO:0072287","count":15}]},{"hash":"521005287052536979","title":"RNA Splicing and Translation Initiation Regulation","description":"The top GO terms cluster around spliceosome-mediated mRNA processing (alternative splicing, splice site recognition, mRNA modification) and the assembly of translation initiation machinery (preinitiation complex, eIF4F). The presence of regulatory ncRNA-mediated gene silencing and blastocyst formation hints at developmental and post-transcriptional regulatory roles. Taken together, these terms point to a cohesive function in RNA maturation and the initiation of protein synthesis, justifying a label focused on RNA processing and translation initiation regulation.","confidence":"High","size":22,"edges":4,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001825","count":5},{"id":"GO:0031047","count":4},{"id":"GO:0048025","count":4},{"id":"GO:0016556","count":3},{"id":"GO:0001731","count":3}]},{"hash":"2101475138852494411","title":"Neuronal development and synaptic signaling","description":"This cluster is driven by GO terms centered on nervous system development, forebrain development, and excitatory postsynaptic potential, pointing to neuronal differentiation and synaptic activity. Additional terms for mitochondrial fission and autophagosome assembly suggest neuron-specific maintenance and turnover processes, while sporulation and spliceosome terms appear as broader cellular processes that can be shared across contexts. Overall, the strongest signal is neuronal development and synaptic function, with supportive but less central cellular processes.","confidence":"Medium","size":22,"edges":9,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031321","count":3},{"id":"GO:0097178","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0000266","count":3},{"id":"GO:0000278","count":3}]},{"hash":"83785924545725453","title":"Ribosome biogenesis and translation","description":"The top terms are dominated by translation, ribosome biogenesis/assembly, and ribosomal subunit export/processing, indicating this cluster mainly comprises components of ribosome production and the protein synthesis machinery, with supporting rRNA processing steps and maturation. ","confidence":"High","size":22,"edges":227,"triangles":1466,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":16},{"id":"GO:0000027","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0006407","count":3}]},{"hash":"1819689404963711608","title":"Mitochondrial metabolism and cristae biogenesis","description":"Most of the top GO terms point to mitochondrial function: protein import into the intermembrane space, cristae formation, heme biosynthesis, mitochondrial calcium homeostasis, and mitochondrial DNA-templated transcription. Redox processes and vitamin E response further support a mitochondrial redox/metabolic theme. A couple of terms (cell adhesion) are less aligned, but the overall signal is mitochondrial structure and metabolism.","confidence":"High","size":22,"edges":173,"triangles":670,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006351","count":3},{"id":"GO:0006783","count":2},{"id":"GO:0045041","count":2},{"id":"GO:0042407","count":2}]},{"hash":"1616203095863999987","title":"Muscle Development and Metabolic Signaling","description":"The cluster centers on muscle-related processes (sarcomere organization, heart development, locomotion) with associated signaling (Rho, cAMP, insulin response) and metabolic pathways (NAD+ and nucleotide biosynthesis), suggesting a coherent theme of muscle development/function coupled with metabolic regulation.","confidence":"Medium","size":22,"edges":9,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0009435","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0006015","count":4}]},{"hash":"1194052333120764489","title":"Glutamatergic synapse formation and adhesion","description":"This cluster is characterized by terms related to glutamatergic synaptic transmission, synapse assembly, nervous system development, and cell-cell adhesion (homophilic/heterophilic), plus regulation of synapse formation and short-term plasticity and Rho signaling. Although an ossification term appears, the dominant signal is neural connectivity and synaptic organization.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0007416","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0043931","count":3}]},{"hash":"901383928359591371","title":"Protein acetylation and chromatin modification","description":"Most prominent terms relate to protein acetylation (peptidyl-lysine N6-acetylation, N-terminal acetylation) and histone acetylation, suggesting a regulatory role in chromatin/package of gene expression; other GO terms appear noisier or peripheral, so the acetylation/chromatin theme best explains the cluster.","confidence":"Medium","size":22,"edges":9,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001525","count":10},{"id":"GO:0006348","count":8},{"id":"GO:0018003","count":8},{"id":"GO:0006044","count":7},{"id":"GO:0010125","count":7}]},{"hash":"704747173399513575","title":"Neural development and stress-immune signaling","description":"This cluster is driven by strong signals for brain development (striatum development) alongside innate immune response and stress-related cellular responses (oxidative stress from hydrogen peroxide and cadmium exposure). The mix suggests proteins that function in neural development with concurrent stress and immune signaling; some terms are obsolete or plant-specific, but the core theme of neural development with stress/immune pathways is consistent.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0021756","count":10},{"id":"GO:0045087","count":9},{"id":"GO:0051301","count":8},{"id":"GO:0070389","count":7},{"id":"GO:0070301","count":7}]},{"hash":"1663162360753651502","title":"Cartilage ECM Remodeling and Integrin Signaling","description":"The cluster is dominated by extracellular matrix-related processes (collagen biosynthesis, collagen fibril organization, cell-matrix and integrin-mediated adhesion) alongside signaling pathways (BMP and VEGF signaling, Notch processing) and chondrocyte differentiation regulation, indicating coordinated ECM remodeling and signaling in cartilage development. A peripheral note is the manganese ion response, which may reflect broader metal-dependent enzyme activity in the ECM milieu.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1900748","count":8},{"id":"GO:0032331","count":8},{"id":"GO:0007160","count":7},{"id":"GO:0007220","count":6},{"id":"GO:0030199","count":6}]},{"hash":"1973263222301923976","title":"Systemic physiological regulation","description":"The top GO terms span diverse physiological processes across multiple systems, including immune response to lipopolysaccharide, blood coagulation, renal sodium excretion, uterine smooth muscle contraction, animal behavior (grooming), energy metabolism (electron transport chain), growth regulation, learning and perception (visual learning, pain regulation), and endocrine control (insulin secretion). This broad mix suggests the proteins participate in generalized, multi-tissue regulatory roles rather than a single cohesive pathway, so a concise label like \u201cSystemic physiological regulation\u201d captures the overall theme without overcommitting to a specific function.","confidence":"Low","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0035815","count":6},{"id":"GO:0070474","count":6},{"id":"GO:0007625","count":6}]},{"hash":"1283674087501720229","title":"Multi-tissue developmental differentiation","description":"The top GO terms span diverse developmental lineages (pituitary, skeletal muscle, pancreatic, cartilage, placental, and left-right patterning) and morphogenetic processes, suggesting a broad role in tissue differentiation rather than a single pathway; thus a cross-tissue developmental theme fits best.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0007519","count":5},{"id":"GO:0045648","count":5},{"id":"GO:0003323","count":5}]},{"hash":"112166644980620606","title":"Excitatory synaptic transmission and plasticity","description":"The top GO terms are dominated by chemical synaptic transmission, glutamate secretion, and regulation of synaptic plasticity, including long-term depression and EPSP modulation, as well as synapse structure regulation and ephrin signaling, all pointing to excitatory glutamatergic synapse function and its plasticity. Some terms also touch on higher-level neural phenomena like sensory perception of sound and social behavior, which fit within neuronal synapse signaling contexts. This cohesive theme supports labeling the cluster as excitatory synaptic transmission and plasticity.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019933","count":3},{"id":"GO:1900383","count":3},{"id":"GO:1901187","count":3},{"id":"GO:0007268","count":3},{"id":"GO:0014047","count":3}]},{"hash":"1424658234511730280","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045746","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0044331","count":2}]},{"hash":"93786412243137668","title":"Innate Immune Signaling and Cytoskeleton Dynamics","description":"The top GO terms point to innate immune responses (innate and adaptive), regulation of JNK and interferon signaling, and cytoskeletal/trafficking processes (endocytosis, Rho signaling, actin localization), plus ubiquitin-dependent protein turnover. This combination suggests a core theme of immune signal transduction intertwined with cytoskeletal remodeling and protein degradation, fitting a cohesive cluster of immune signaling linked to trafficking and cytoskeleton dynamics.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0046328","count":6},{"id":"GO:0060335","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0007275","count":5}]},{"hash":"1028339210190824286","title":"Estrogen-responsive Developmental Signaling","description":"This cluster is most clearly tied to hormonal and developmental processes, with multiple GO terms for response to estrogen and development of reproductive organs (vagina, thymus) and organ regeneration. Cholesterol biosynthesis can feed into steroid hormone production, supporting estrogen signaling, while other terms touch on apoptosis and metabolic processes; however, the dominant theme appears to be estrogen-related developmental signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043627","count":4},{"id":"GO:0016310","count":3},{"id":"GO:2001240","count":3},{"id":"GO:0060068","count":2},{"id":"GO:0006695","count":2}]},{"hash":"1785677640961842320","title":"Neural Development and Synaptic Function","description":"The cluster\u2019s top GO terms cluster around neural development and synaptic activity (long-term synaptic potentiation, innervation, neuron projection development, short-term memory), suggesting a neural connectivity/plasticity theme. There are additional terms related to heart development and heart-rate regulation, indicating some cardiovascular associations as well, but the strongest shared signal is neural development and synaptic function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0060384","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0007614","count":2}]},{"hash":"846159954638544482","title":"Rho GTPase\u2013driven cytoskeletal remodeling and filopodia","description":"Based on the GO terms, the cluster centers on small GTPase signaling (Rho family) and cytoskeletal dynamics, including filopodium assembly and its regulation, along with cell spreading and vesicle trafficking (COPII loading). Although heart and neuron development appear, the consolidated theme is Rho-mediated actin remodeling and protrusion formation, with supporting roles in trafficking and signaling. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0048666","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1134285164488787796","title":"Neuronal Signaling and Locomotion","description":"The top GO terms are clearly centered on neural communication and movement: excitatory postsynaptic potentials, glutamatergic synaptic transmission, GABA signaling, and ion transport (Na+/K+), along with locomotory behavior and conditioned taste aversion. These together point to a function group of neuronal signaling pathways involved in controlling movement and learning. A single immune-related term appears but does not define the cluster\u2019s core theme.","confidence":"High","size":22,"edges":13,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":19},{"id":"GO:0060079","count":18},{"id":"GO:0071805","count":18},{"id":"GO:0035725","count":18},{"id":"GO:0001661","count":18}]},{"hash":"1133538441138128890","title":"Vesicle trafficking and exocytosis regulation","description":"This cluster centers on processes governing vesicle movement and fusion (intracellular transport, synaptic vesicle priming, synaptic vesicle exocytosis) and cytoskeletal signaling (Rho/Ras pathways) with specific contexts like the acrosome reaction and mating projection growth, pointing to a shared theme of regulated vesicle dynamics and exocytosis across cell types. Confidence: High","confidence":"","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007340","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0031384","count":5},{"id":"GO:0043314","count":5}]},{"hash":"131544486510756067","title":"Presynaptic Vesicle Exocytosis and Secretion","description":"This cluster is dominated by GO terms for secretory and vesicle-trafficking processes in neurons: presynaptic dense core vesicle exocytosis, neurotransmitter secretion, and synaptic vesicle maturation. Additional terms for endosome-to-lysosome transport and plasma membrane localization support a unifying theme of vesicle trafficking and secretion, with insulin secretion extending the secretory context. Some terms related to megakaryocyte development and pigmentation are ancillary and don\u2019t diminish the core vesicle-trafficking signal.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0099525","count":5},{"id":"GO:0007269","count":5},{"id":"GO:0016188","count":5},{"id":"GO:0035855","count":4},{"id":"GO:0043524","count":4}]},{"hash":"192734079670672106","title":"Rho-Driven Cytoskeleton and Cell Migration","description":"This cluster centers on GO terms for regulation of Rho signaling, actin filament organization (stress fibers, filopodia), and processes like cell spreading and adhesion, pointing to cytoskeletal remodeling driving cell movement. Additional terms on acrosome reaction and synaptic vesicle priming suggest vesicle trafficking linked to cytoskeletal dynamics, reinforcing a theme of coordinated cytoskeleton remodeling and motility.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0051496","count":5},{"id":"GO:0007340","count":5},{"id":"GO:0002692","count":5},{"id":"GO:0043314","count":5}]},{"hash":"635106393595983892","title":"Insulin/IGF signaling with metabolic and cytoskeletal regulation","description":"The top GO terms cluster around insulin receptor signaling, IGF signaling, and metabolic processes (glycogen, glucose, fatty acids) as well as Rho-mediated cytoskeletal dynamics (filopodium assembly). This suggests a group of proteins coordinated by insulin/IGF signals that regulate metabolism and actin remodeling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":5},{"id":"GO:0045725","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0051489","count":4},{"id":"GO:0032000","count":3}]},{"hash":"1071444752271861509","title":"Signaling regulation and protein turnover","description":"This cluster is enriched for terms related to control of signaling (positive regulation of GTPase activity; positive regulation of serine/threonine kinase activity and autophosphorylation) and protein homeostasis (ubiquitin-dependent protein catabolic process). Additional terms point to RNA transport and nuclear import, as well as cell cycle and development, suggesting a broader role in regulating cellular state and protein turnover rather than a single straightforward pathway. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0006511","count":6},{"id":"GO:0071902","count":5},{"id":"GO:0031954","count":5},{"id":"GO:0051028","count":5}]},{"hash":"945112996358510183","title":"Membrane trafficking and organelle signaling regulators","description":"The top GO terms cluster around membrane-related regulation, including GPCR internalization, negative regulation of membrane tubulation, and regulation of mitochondrial membrane permeability and protein import into the mitochondrial matrix. This suggests a theme of proteins that modulate membrane dynamics and inter-organelle signaling, with some linkage to broader signaling and cell-cycle control. While the terms are diverse, the common thread is regulation of membrane processes and organelle interactions, justifying a label focused on trafficking and organelle signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903526","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0002031","count":3},{"id":"GO:2000134","count":2},{"id":"GO:0030150","count":2}]},{"hash":"2118305080462826268","title":"Dopaminergic and Adrenergic Signaling","description":"Reasoning: The top GO terms cluster around dopaminergic synaptic transmission and adrenergic receptor signaling, with downstream effects including heart rate regulation by epinephrine/norepinephrine, prepulse inhibition, and metabolic processes like diet-induced thermogenesis. The mix of neural signaling and systemic cardiovascular/metabolic responses suggests a coherent theme of catecholamine-driven neuroendocrine signaling. Some terms (reproductive process, xenobiotic response) may reflect broader roles but do not undermine the central catecholamine signaling theme.","confidence":"High","size":22,"edges":164,"triangles":588,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":22},{"id":"GO:0071883","count":22},{"id":"GO:0001996","count":22},{"id":"GO:0048609","count":22},{"id":"GO:0051967","count":22}]},{"hash":"1282451202473919647","title":"GPCR-Mediated Pain and Cardiovascular Signaling","description":"These top GO terms cluster around G protein-coupled receptor signaling, including GPCR internalization, adenylate cyclase activation, and PLC/Calcium signaling, with downstream effects on smooth muscle contraction and blood pressure, and also touch on pain perception and thermogenic/metabolic responses. Together, they point to a GPCR-driven signaling module coordinating nociceptive signaling and vascular/metabolic regulation, which justifies a label centered on GPCR signaling in pain and cardiovascular function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0007596","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0007190","count":8}]},{"hash":"1315650892876450591","title":"Glycan biosynthesis and glycosylation","description":"Most terms center on glycan metabolism and glycosylation: N-linked glycosylation via asparagine, N-glycan processing, oligosaccharide metabolic processes, and protein sialylation, including ganglioside biosynthesis. Some entries (e.g., olfactory placode morphogenesis) appear ancillary or outdated, but the dominant signal is glycans\u2019 assembly and modification across proteins. This supports a cohesive cluster label around glycan biosynthesis and glycosylation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":4},{"id":"GO:0071699","count":3},{"id":"GO:0018279","count":3},{"id":"GO:0006054","count":3},{"id":"GO:0006491","count":3}]},{"hash":"1767294400894039538","title":"GPCR Signaling and Innate Immunity","description":"The Top Terms indicate strong enrichment for GPCR-mediated signaling (adenylate cyclase activation and PLC activation) and immune defense, including innate immune response and defense against Gram-negative bacteria. Additional terms reference development and angiogenesis, feeding behaviors, and pain, which may reflect pleiotropy or shared signaling networks but do not override the dominant GPCR-immune theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0007189","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0050829","count":3},{"id":"GO:0007190","count":3}]},{"hash":"918829750305025814","title":"Neural Sensory Perception and Neuroendocrine Signaling","description":"The top GO terms point to neural development (cerebellar granule cell differentiation), multiple sensory modalities (thermoception, response to cold, perception of pain), and a neuroendocrine role (vasopressin secretion), with an additional signaling pathway term (NOD1). This suggests a cohesive brain-related cluster involving sensory processing and hormonal signaling, rather than a single isolated process.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":8},{"id":"GO:0035994","count":8},{"id":"GO:0050955","count":8},{"id":"GO:0009409","count":8},{"id":"GO:0030103","count":8}]},{"hash":"690578661670144893","title":"Embryonic development and tissue morphogenesis","description":"These terms cluster around development and differentiation across multiple tissues (pancreas, placenta, heart cushion, cartilage, endocrine system, inner ear, liver). They reflect broad embryonic development and organogenesis rather than a single pathway or tissue-specific function, so the label emphasizes a developmental theme rather than a specific process.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":5},{"id":"GO:0060806","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0003198","count":4}]},{"hash":"2104368533118525400","title":"Immune signaling and cytoskeletal regulation","description":"This label captures the prominent immune-related terms (B cell receptor signaling, innate immune response, STAT phosphorylation, NF-kappaB-related regulation) and the accompanying hints of cytoskeletal dynamics (sarcomere organization, Rho signaling). While autophagy and nuclear localization terms are present, they appear ancillary to the core immune signaling theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042517","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0032258","count":2},{"id":"GO:0051457","count":2}]},{"hash":"1276827535821821049","title":"Negative Regulation of Signaling and Synaptic Organization","description":"Most terms describe negative regulation of signaling pathways (MAPK/ERK, PI3K-AKT, T cell signaling) and structural organization at synapses (postsynaptic density, synaptic vesicle clustering). A common thread is inhibitory control of signaling coupled with assembly/organization of neuronal or cellular structures. Hence the name reflects both signaling inhibition and synaptic/structural regulation.","confidence":"High","size":21,"edges":179,"triangles":842,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":18},{"id":"GO:0000200","count":18},{"id":"GO:0050860","count":18},{"id":"GO:0034501","count":16},{"id":"GO:0051898","count":16}]},{"hash":"2090609623827755934","title":"Kinase signaling and protein oligomerization","description":"This cluster centers on regulation of protein phosphorylation (serine/threonine kinase activity and autophosphorylation) and on forming multi-subunit complexes (heterotrimerization and homooligomerization), implying a role in signaling pathways that depend on kinase activity and protein assembly. Additional terms like GTPase activity regulation and mRNA transport point to broader cellular regulatory functions, while some context-specific terms (skin development, hypoxia, mitotic cell cycle) reflect broader cellular processes rather than a single pathway. Overall, the core theme is phosphorylation-driven signaling coupled with protein complex formation.","confidence":"Medium","size":21,"edges":16,"triangles":6,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070208","count":10},{"id":"GO:0030433","count":8},{"id":"GO:0043588","count":8},{"id":"GO:0071902","count":7},{"id":"GO:0031954","count":7}]},{"hash":"1072470033593769983","title":"Neural Development and Morphogenesis","description":"The top GO terms are dominated by neural development (neuron projection development, neural tube closure) plus broad developmental processes (multicellular organism development, skeletal system development) and cell migration, indicating a cohesive theme around developmental patterning and neural formation. Some terms related to stress or immune responses appear less central and may reflect pleiotropic annotations rather than core cluster function. Overall, the cluster centers on developmental and neural morphogenesis. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0001843","count":4}]},{"hash":"694179923316352277","title":"Neuronal dendrite morphogenesis and ephrin signaling","description":"This cluster is dominated by terms related to neuronal development, especially dendrite development and morphogenesis, along with ephrin receptor signaling, suggesting a coherent theme of neural differentiation and dendritic signaling. A few terms about plant leaf development and xenobiotic response appear incidental and do not override the neural pattern.","confidence":"High","size":21,"edges":149,"triangles":514,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:1902213","count":2},{"id":"GO:0048366","count":2},{"id":"GO:1900170","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0050775","count":2}]},{"hash":"21233568682275264","title":"KIT receptor tyrosine kinase signaling","description":"This cluster is dominated by KIT signaling and related RTK pathways, with multiple terms pointing to collagen-activated RTK signaling and ERK1/2 cascade regulation, plus links to cytoskeletal remodeling and ubiquitin-dependent processes. The strongest connection is KIT signaling, suggesting the cluster represents KIT/RTK-ERK\u2013driven signaling with cytoskeletal regulation.","confidence":"High","size":21,"edges":30,"triangles":16,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038109","count":19},{"id":"GO:2001275","count":19},{"id":"GO:0071732","count":19},{"id":"GO:0032436","count":19},{"id":"GO:0001865","count":19}]},{"hash":"99670696189775978","title":"Chemical Stress and Inflammatory Signaling","description":"This cluster is enriched for GO terms related to responses to toxins and xenobiotics, redox processes, nitric oxide production, prostaglandin secretion, and regulation of inflammatory cytokines, pointing to a coordinated detox/chemical stress response and inflammatory signaling rather than a developmental program. A couple of developmental terms appear but are not central to the overall theme.","confidence":"Medium","size":21,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0007584","count":3}]},{"hash":"2217432502768423573","title":"Ribosome biogenesis and translation machinery","description":"This cluster is dominated by GO terms related to ribosome assembly and protein synthesis, including ribosome biogenesis, rRNA pseudouridine synthesis, maturation of rRNA, translation, and initiation/reinitiation. A single term about JNK regulation is a less central outlier, but the core signal points to components involved in ribosome assembly and the translation process.","confidence":"High","size":21,"edges":188,"triangles":968,"max_degree":20,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":7},{"id":"GO:0031118","count":5},{"id":"GO:0006412","count":5},{"id":"GO:0007338","count":5},{"id":"GO:0031120","count":5}]},{"hash":"1593333871328288972","title":"Embryonic organ morphogenesis and eye development","description":"These GO terms cluster around embryonic development and organ morphogenesis, with strong signals for eye development (camera-type eye, embryonic eye morphogenesis, lens epithelial proliferation, amacrine cell differentiation) and neural patterning (floor plate, somites) along with broader organogenesis (pancreas, lung). The common thread is embryonic morphogenesis across multiple tissues, justifying the label.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0031018","count":11},{"id":"GO:0060441","count":11},{"id":"GO:0043010","count":11},{"id":"GO:0048048","count":11}]},{"hash":"1699969138377338308","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster is dominated by GO terms related to ubiquitination and ubiquitin-mediated protein breakdown, including ubiquitin-dependent protein catabolic process, polyubiquitination, autoubiquitination, and K48-linked ubiquitination, indicating a core link to tagging proteins for proteasomal degradation. Additional terms like regulation of JNK cascade, circadian rhythm, and Vitamin D response may reflect broader regulatory roles of ubiquitinated proteins, but the central theme is ubiquitin-driven protein turnover. High confidence.","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0051865","count":7},{"id":"GO:0000209","count":6},{"id":"GO:0070936","count":6},{"id":"GO:0046328","count":6}]},{"hash":"917206809216836978","title":"Neural development and adhesion-driven organ morphogenesis","description":"This cluster combines strong signals for cell\u2013cell adhesion (heterophilic/homophilic), nervous system development, synapse assembly, and neuronal progenitor maintenance, plus planar polarity and branching morphogenesis in organs (lung) and bone maturation, suggesting a theme of neural development intertwined with adhesion- and polarity-guided morphogenesis.","confidence":"High","size":21,"edges":10,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":21},{"id":"GO:0007156","count":21},{"id":"GO:0051965","count":20},{"id":"GO:0043931","count":19},{"id":"GO:0007399","count":19}]},{"hash":"334823816947042369","title":"Spliceosome-driven RNA processing and rRNA maturation","description":"The cluster is dominated by GO terms for mRNA splicing via the spliceosome and its regulation, along with maturation and processing steps for LSU rRNA, indicating a core theme of RNA metabolism focused on splicing and ribosomal RNA maturation, with additional links to transcription-related processes; this labeling captures the primary functional axis while remaining concise.","confidence":"High","size":21,"edges":203,"triangles":1218,"max_degree":20,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":17},{"id":"GO:0031047","count":17},{"id":"GO:0000398","count":15},{"id":"GO:0000464","count":15},{"id":"GO:0006369","count":15}]},{"hash":"1998741495167990325","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0000390","count":1},{"id":"GO:1902570","count":1}]},{"hash":"1550359395575494058","title":"Neuro-immune signaling and myelination","description":"The cluster shows strong enrichment for innate immune processes (innate immune response, complement activation, cytokine production, T cell proliferation) alongside neural development terms (myelination, trigeminal nerve structure, branchiomotor neuron axon guidance, axonal fasciculation, synapse assembly). This combination points to proteins involved in neural development that are influenced by immune signaling, especially in sensory neural pathways like the trigeminal system. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":14},{"id":"GO:0014068","count":13},{"id":"GO:0006958","count":13},{"id":"GO:0051965","count":13},{"id":"GO:0007413","count":13}]},{"hash":"607713836598483938","title":"T cell activation and adhesion in adaptive immunity","description":"The terms point to coordinated T cell\u2013based immune activation: cell-cell adhesion molecules, adaptive immune response, T cell proliferation and costimulation, and TCR\u2013MHC\u2013mediated signaling, with CCR7 pathway involvement and NK cell cytotoxicity. Peptidoglycan detection hints at innate cues feeding into adaptive responses, and GI epithelium maintenance aligns with mucosal immune interfaces, making a cohesive module of adaptive immunity and T cell activation.","confidence":"High","size":21,"edges":181,"triangles":875,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":10},{"id":"GO:0007156","count":10},{"id":"GO:0002250","count":10},{"id":"GO:0042102","count":10},{"id":"GO:0031295","count":10}]},{"hash":"16167666257202421","title":"Rho GTPase\u2013Mediated Actin Remodeling and Migration","description":"This cluster is dominated by GO terms tied to Rho and small GTPase signaling, actin cytoskeleton organization, and cell migration (regulation of Rho protein signal transduction, actin cytoskeleton organization, small GTPase-mediated signal transduction, cell migration). Additional terms for plasma membrane tubulation and substrate adhesion-dependent spreading support roles in membrane-associated actin remodeling and motility. A few terms about heart development or synaptic depression may reflect broader contexts, but the recurring theme is cytoskeletal dynamics driving cell movement.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0097320","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1581169010983997940","title":"Gram-positive lipid biosynthesis and siderophore production","description":"This cluster is enriched for lipoteichoic acid biosynthesis and various fatty acid metabolic processes, along with siderophore biosynthetic activity and nonribosomal peptide\u2013related amino acid activation, pointing to a cohesive role in Gram-positive bacterial lipid envelope construction and secondary metabolite production; an occasional plant-related term appears to be noise.","confidence":"High","size":21,"edges":150,"triangles":559,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":11},{"id":"GO:0006633","count":10},{"id":"GO:0019654","count":10},{"id":"GO:1902987","count":10},{"id":"GO:0010214","count":10}]},{"hash":"853961476975392063","title":"Unknown","description":"The top GO terms are highly diverse, covering metabolic processes (retinol/retinal, fructose, progesterone), a neural development term (lateral motor column neuron migration), vascular-related processes (platelet aggregation, smooth muscle proliferation), and oxidative stress response (cellular response to hydrogen peroxide). There isn't a single coherent biological function tying these terms together, suggesting this cluster represents a heterogeneous mix of metabolic and signaling roles rather than one clear pathway.","confidence":"","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"wound healing","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0046370","count":10},{"id":"GO:0042572","count":10},{"id":"GO:0097477","count":9},{"id":"GO:0070527","count":9}]},{"hash":"1512976767100419108","title":"Neural development and synapse assembly","description":"The top GO terms are strongly centered on nervous system development, multicellular organism development, and positive regulation of synapse assembly, plus cell\u2013cell adhesion relevant to neural connectivity, pointing to a core theme of neural development and synaptic formation. While terms like ossification, sodium transport regulation, proteolysis, and innate immune response appear, they are less dominant and do not override the neural development focus. Overall, the cluster seems best characterized by neural differentiation and synapse assembly processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0007275","count":14},{"id":"GO:0007157","count":14},{"id":"GO:0043931","count":14}]},{"hash":"1549884389497149652","title":"Fatty acid oxidation and glycogen metabolism","description":"The top GO terms cluster around energy metabolism: fatty acid catabolic processes (long- and medium-chain), carnitine biosynthesis/metabolism (key for FA transport into mitochondria), and glycogen biosynthesis, with related starvation and cold response terms. An outlier muscle-related term (heart development) and some noise terms likely reflect annotation artifacts rather than core function. Overall, the group seems centered on energy production and nutrient storage pathways.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0042758","count":3},{"id":"GO:0045329","count":3}]},{"hash":"1973826690758189562","title":"Growth signaling and gene expression regulation","description":"The GO terms cluster around nutrient/growth signaling (TORC1 signaling; positive regulation of GTPase activity) coupled with core gene expression and protein synthesis processes (peptidyl-serine dephosphorylation, mRNA transport, translation preinitiation complex formation, DNA-templated transcription). Additional terms touch on cell morphology and membrane docking, linking signaling to transcription/translation and cellular structure. This suggests a cohesive theme of coordinating growth signals with gene expression and protein synthesis, hence the label. ","confidence":"Medium","size":21,"edges":18,"triangles":5,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0038202","count":3},{"id":"GO:0070262","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0001731","count":3}]},{"hash":"2148144182151274383","title":"Developmental Signaling and Differentiation","description":"The GO terms cluster around major signaling pathways (Wnt and Hippo) that regulate development and tissue growth, along with differentiation processes (keratinocyte differentiation, vascular development) and broader stimulus responses (GM-CSF, prostaglandin). This suggests a cohesive theme of signaling coordinating cell fate, growth, and differentiation rather than a single narrow function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097011","count":18},{"id":"GO:0006915","count":17},{"id":"GO:0060044","count":17},{"id":"GO:0090263","count":17},{"id":"GO:0030216","count":17}]},{"hash":"1938840984545414243","title":"Mesodermal muscle, heart, bone, and vessel differentiation","description":"The cluster\u2019s top GO terms point to development and differentiation of mesodermal tissues: muscle (skeletal muscle cell differentiation, myoblast differentiation), heart development (outflow tract morphogenesis, secondary heart field specification), bone formation (osteoblast differentiation), and vascular-related healing. The inclusion of transcription by RNA polymerase II and calcium signaling supports coordinated regulatory activity across these differentiation programs, making a cohesive theme of mesoderm-derived tissue development.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0071277","count":12},{"id":"GO:0045669","count":12},{"id":"GO:0003151","count":11},{"id":"GO:0035470","count":10}]},{"hash":"229256460006700344","title":"Ubiquitin-regulated immune signaling and antigen presentation","description":"This cluster appears to combine ubiquitin-related regulation (deubiquitination, ERAD) with immune signaling and antigen processing terms (T cell receptor signaling, Fc-epsilon receptor signaling, MHC I\u2013dependent antigen presentation), pointing to ubiquitin-dependent control of immune responses and antigen presentation. Additional terms on mRNA stability and cell cycle regulation may reflect broader post-transcriptional or cell-cycle links to immune activity.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":7},{"id":"GO:0050852","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0035523","count":5},{"id":"GO:0043488","count":5}]},{"hash":"1879703820702402354","title":"Neural signaling and development","description":"The top GO terms center on neural communication (glycinergic transmission, glycine secretion, dopamine catabolic process, serotonin uptake) and brain development (thalamus development), with supporting glial growth (perineurial glial growth) and growth factor signaling (response to TGF-beta). A triglyceride biosynthesis term is present but secondary, so the dominant theme is neural signaling and development.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0042066","count":2},{"id":"GO:0060012","count":2},{"id":"GO:0042420","count":2}]},{"hash":"440701621488391356","title":"Ribosome Biogenesis and LSU rRNA Processing","description":"Most of the top GO terms are directly related to ribosome assembly and rRNA maturation (LSU rRNA maturation, ribosomal large subunit biogenesis, ribosome biogenesis, ITS1 cleavage), indicating a coherent cluster of proteins involved in ribosome production. The few non-ribosome terms appear less frequent and do not dominate the set, so the primary theme is ribosome biogenesis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0043981","count":3},{"id":"GO:0043982","count":3}]},{"hash":"1087287031600713797","title":"Drosophila ovarian follicle morphogenesis and Notch signaling","description":"The top GO terms cluster around Drosophila ovarian development: follicle cell adhesion, maintenance of polarity in the follicular epithelium, egg chamber myoepithelia, and female meiotic division, all pointing to egg chamber morphogenesis. The inclusion of Notch signaling regulation reinforces a regulatory pattern typical of follicle cell differentiation, while related developmental terms (imaginal discs, leg segmentation) reflect broader Drosophila development context. Metabolic terms (glycogen, UDP-galactose) likely support energy and biosynthesis during rapid tissue growth but do not define the core theme.","confidence":"High","size":21,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":3},{"id":"GO:0045600","count":3},{"id":"GO:0007299","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0001744","count":2}]},{"hash":"1758134698847158365","title":"Proteoglycan Biosynthesis and ECM Components","description":"This cluster is dominated by biosynthetic processes for proteoglycans, including chondroitin sulfate, heparan sulfate, and heparin proteoglycans (GO:0050650, GO:0015012, GO:0030210), pointing to extracellular matrix (ECM) components as the core theme. Obsolete glycosylation and stress-response terms are present but appear ancillary to the main ECM/GAG biosynthesis function. Overall, the proteins appear to cluster around proteoglycan production and ECM biology.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0070301","count":2},{"id":"GO:0042149","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0006511","count":2}]},{"hash":"1620736639719219588","title":"Coagulation and complement-activated vascular response","description":"The cluster is dominated by GO terms related to blood coagulation (including classical pathway) and complement activation (both classical and lectin pathways), plus endothelial barrier regulation, which together point to hemostasis with vascular and immune interactions. Additional signals for collagen catabolic process and biomineral tissue development suggest extracellular matrix remodeling, while lipopolysaccharide response indicates inflammatory signaling. Overall, these terms converge on a function in coagulation within an immune-vascular context.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031214","count":7},{"id":"GO:0030194","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0007586","count":7},{"id":"GO:0001867","count":7}]},{"hash":"997985331295441444","title":"Multi-tissue embryonic organogenesis","description":"The prominent GO terms describe embryonic development across diverse tissues (pharyngeal system, inner ear, mouth/palate, teeth, telencephalon, primitive streak, ureteric bud branching). The shared theme is developmental regulation during organ formation rather than a single molecular function. Therefore, a concise label like Multi-tissue embryonic organogenesis captures the cluster's broad developmental nature.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0060037","count":7},{"id":"GO:0048839","count":7},{"id":"GO:0008584","count":7},{"id":"GO:0060021","count":7}]},{"hash":"2231769537626834234","title":"Vertebrate embryogenesis and craniofacial development","description":"Top GO terms show early embryonic processes (primitive streak formation, transcription by RNA polymerase II) and craniofacial organogenesis (neural crest cell migration, eye morphogenesis, odontogenesis, palate development), along with broader transcription regulation. This combination indicates a cohesive theme of vertebrate embryonic development with a strong craniofacial focus.","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0090009","count":10},{"id":"GO:0090190","count":10},{"id":"GO:0001755","count":10},{"id":"GO:0006366","count":9}]},{"hash":"61558495569585219","title":"Neural and craniofacial development","description":"This cluster centers on embryonic neural development (midbrain and forebrain formation, neuronal differentiation, forebrain proliferation) and craniofacial/skeletal morphogenesis (roof of mouth/palate development, hindlimb morphogenesis, skeletal development), with pituitary organ development and gene-expression regulation terms suggesting coordinated developmental programs. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":9},{"id":"GO:0048706","count":8},{"id":"GO:0021524","count":8}]},{"hash":"1586438409029679390","title":"NF-kappaB\u2013driven innate inflammatory signaling","description":"The top GO terms cluster around innate immune activation and inflammatory regulation, especially NF-kappaB pathway activation (positive regulation of NF-kappaB transcription factor activity and canonical NF-kappaB signaling), cytokine production (IL-6, GM-CSF), neutrophil chemotaxis, and the overall innate immune response. This suggests a cohesive set of proteins that participate in NF-kB\u2013mediated inflammatory signaling and early immune defense, with some links to apoptosis and host-pathogen interactions. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:2000778","count":3},{"id":"GO:0097192","count":3},{"id":"GO:0032725","count":3},{"id":"GO:0030593","count":3}]},{"hash":"1302624111995370894","title":"Adrenergic GPCR Signaling and Thermogenesis","description":"These proteins are enriched for adrenergic receptor signaling and downstream cAMP pathways (activation of adenylate cyclase, GPCR signaling), which drive cardiovascular responses such as heart rate and blood pressure regulation via epinephrine/norepinephrine. They also connect to thermogenic and metabolic processes (diet-induced thermogenesis, electron transport chain) and dopaminergic signaling, indicating a cluster centered on sympathetic signaling and energy regulation.","confidence":"High","size":21,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0007190","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0002024","count":15}]},{"hash":"1588015540299904464","title":"Cell surface signaling and cytoskeletal dynamics","description":"The GO terms cluster around membrane-associated signaling and structural remodeling: integrin-mediated signaling, filopodium assembly, and ectodomain proteolysis hint at adhesion and receptor signaling; symbiont entry into host cells and dendritic spine maintenance point to cytoskeletal rearrangements and membrane interactions; extrinsic apoptotic signaling and hepatocyte apoptosis indicate signaling cross-talk with cell death. While diverse, the common thread is membrane-proximal signaling and cytoskeletal dynamics guiding cell interactions and shape, with occasional tissue-specific roles.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097062","count":4},{"id":"GO:0097284","count":4},{"id":"GO:0051044","count":4},{"id":"GO:0032088","count":3},{"id":"GO:0010745","count":3}]},{"hash":"655299102915553715","title":"Mitochondrial and Membrane Transport","description":"Top terms cluster around transmembrane transport of diverse substrates (deoxynucleotides, coenzyme A, thiamine pyrophosphate, glycine, manganese) and mitochondrial-focused processes (mitochondrial ATP transport, regulation of mitochondrial membrane potential). A few terms relate to fatty acid response or oxidative stress, but the dominant signal is membrane transport tied to mitochondrial energy homeostasis.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070542","count":11},{"id":"GO:0030302","count":10},{"id":"GO:0097274","count":10},{"id":"GO:0035349","count":10},{"id":"GO:0051881","count":10}]},{"hash":"1627234400195494321","title":"Adrenergic Thermogenesis and Cardiovascular Signaling","description":"The cluster shows strong enrichment for diet-induced thermogenesis, cellular response to temperature, and adrenergic signaling (GPCR activation, adenylate cyclase activation, MAPK pathway) as well as cardiovascular regulation terms (heart rate and blood pressure). These together point to a cohesive theme of adrenergic-driven thermogenesis coupled with cardiovascular responses, supported by energy metabolism pathways like the electron transport chain. Confidence: Medium.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0007190","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0010579","count":9}]},{"hash":"1443801160353154622","title":"Neurovascular development signaling","description":"This cluster centers on signaling pathways that govern neural growth and connectivity (axonogenesis, excitatory synaptic activity) as well as vascular and heart development (blood vessel branching, heart development) and cell migration, with emphasis on cytoskeletal regulation via Rho/GTPase signaling and GPCR-related pathways. The presence of both neural and vascular development terms, plus Rho/GTPase regulation, suggests a cohesive theme of coordinated neurovascular development through cytoskeletal signaling and kinase modulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0007409","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0007507","count":4}]},{"hash":"415588773644128211","title":"RNA Pol II Transcription Regulation","description":"The cluster\u2019s top GO terms cluster around transcription by RNA polymerase II, including DNA-templated transcription and both positive and negative regulation of transcription by RNA Pol II, with additional signals for DNA recombination and cell-cycle control (G1/S transition). This suggests a set of proteins primarily involved in regulating transcription, with some DNA metabolism and growth-regulatory roles, making the label RNA Pol II transcription regulation a representative and specific summary of the cluster.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0070301","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0090502","count":3}]},{"hash":"737484721793726316","title":"Ubiquitin-dependent proteolysis","description":"This cluster is dominated by GO terms tied to ubiquitination and subsequent protein degradation, including ubiquitin-dependent catabolic processes, K48- and K6-linked ubiquitination, and polyubiquitination, as well as autoubiquitination and ERAD-related ubiquitination. The inclusion of negative regulation of apoptosis and regulation of the cell cycle suggests a broader role in ubiquitin-mediated control of cell fate and division. The recurring theme is proteins marked for proteasomal degradation via ubiquitin signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0051865","count":9},{"id":"GO:0070936","count":8},{"id":"GO:0043066","count":8},{"id":"GO:0085020","count":8}]},{"hash":"1409774455927416372","title":"RNA Pol II Transcription Regulation","description":"Most of the top GO terms describe transcription-related processes tied to RNA polymerase II, including transcription initiation, transcription regulation, and transcription-coupled DNA repair, with a minor signal for mRNA export regulation and chromatin context. This constellation suggests the cluster comprises transcription regulators and factors involved in RNAP II\u2013coupled processes, hence the label focusing on RNAP II transcription regulation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006283","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060303","count":1},{"id":"GO:0006367","count":1}]},{"hash":"1553587328962881013","title":"TNF-NF-\u03baB signaling and stress-induced apoptosis","description":"Most terms center on inflammatory signaling (TNF signaling, NF-\u03baB regulation), stress responses (LPS, xenobiotic response), and apoptosis pathways (p53-mediated DNA damage). The combination suggests a cluster of proteins involved in immune/stress signaling that can regulate cell survival and growth, rather than a single concrete pathway. Therefore, a label highlighting TNF/NF-\u03baB\u2013related signaling and apoptosis best fits.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034051","count":1},{"id":"GO:0033209","count":1},{"id":"GO:0042347","count":1},{"id":"GO:0042771","count":1},{"id":"GO:0071222","count":1}]},{"hash":"792316403620960098","title":"Mitotic Cell Cycle and Spindle Assembly","description":"The top GO terms are dominated by cell division and mitosis-related processes (cell division, mitotic cell cycle, mitotic spindle assembly), indicating a core theme around mitotic machinery. While there are also terms related to GTPase regulation, intracellular transport, and development, these appear as secondary signals. Thus, the cluster most plausibly reflects mitotic cell cycle and spindle assembly functions, with ancillary transport-related roles.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0090630","count":2}]},{"hash":"2291756476910094892","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around neural activity and synaptic plasticity\u2014excitatory postsynaptic potential, long-term potentiation, and sensory perception of sound and light\u2014support a neural-development/synaptic function theme. While several development terms (heart, bone, neural tube, bronchus morphogenesis) appear, they are less central to the core signal and may reflect broad developmental roles. Overall, the dominant signal is neural development and synaptic signaling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0035176","count":3},{"id":"GO:1900273","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1078928581939836080","title":"Developmental signaling and morphogenesis","description":"The proteins cluster around tissue development across multiple organs (lung, pericardium, myelination, angiogenesis) and include signaling-related GO terms (GPCR signaling, GTPase activity, receptor clustering), implying a coherent theme of developmental signaling guiding morphogenesis.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0003344","count":3},{"id":"GO:0022011","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1617653595291705917","title":"ER stress and innate immune signaling","description":"The top terms cluster around the unfolded protein response in the ER and innate immune activation/chemotaxis, suggesting a core theme where cellular stress responses interface with immune signaling. Additional terms like vesicle endocytosis, cell adhesion/spreading, and cell cycle regulation point to broader signaling roles, but the strongest signal is ER stress linked to immunity, justifying this label.","confidence":"Medium","size":20,"edges":188,"triangles":1105,"max_degree":19,"top_function":"protein folding","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:2000510","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0010204","count":4},{"id":"GO:0048488","count":4}]},{"hash":"401058212942379952","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006284","count":4},{"id":"GO:0006295","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0036297","count":3},{"id":"GO:0050650","count":3}]},{"hash":"2011554802049805668","title":"Ion and sugar transmembrane transporters","description":"The top GO terms cluster around transmembrane transport of a variety of substrates\u2014ions (K+, Na+, phosphate, nitrite), sugars (arabinose, galactose), sialic acid\u2014and related processes like neurotransmitter loading into vesicles, indicating a cohesive group of membrane transport proteins with broad substrate specificity.","confidence":"High","size":20,"edges":10,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071805","count":9},{"id":"GO:1900754","count":8},{"id":"GO:0098700","count":8},{"id":"GO:0015739","count":8},{"id":"GO:0042891","count":8}]},{"hash":"1824099621633165739","title":"Neural development and axon regeneration","description":"Top terms cluster around nervous system development and regulation of axon regeneration, with supporting signals from PKC-related neuronal signaling (phorbol ester response) and extracellular remodeling (metallopeptidase activity). Despite some obsolete terms, the dominant theme is neural development and axon regeneration.","confidence":"High","size":20,"edges":172,"triangles":846,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048679","count":20},{"id":"GO:1902002","count":20},{"id":"GO:1990801","count":20},{"id":"GO:1904628","count":20},{"id":"GO:0030878","count":20}]},{"hash":"231462756246480084","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":23,"triangles":10,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0000480","count":4},{"id":"GO:0000472","count":4},{"id":"GO:0032436","count":3},{"id":"GO:0006349","count":3}]},{"hash":"2249768290071388231","title":"Central carbon metabolism and amino acid biosynthesis","description":"This cluster is dominated by core energy metabolism terms (TCA cycle, glycolytic process, gluconeogenesis) and amino acid pathways (leucine and lysine metabolism, 2-oxoglutarate). The presence of malonyl-CoA biosynthesis further ties to lipid precursor synthesis, supporting a cohesive central metabolism module. A sodium ion transport term appears only tangentially, but the overall pattern points to central carbon flux and amino acid turnover.","confidence":"High","size":20,"edges":187,"triangles":1087,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":11},{"id":"GO:0006103","count":9},{"id":"GO:0019878","count":8},{"id":"GO:0033512","count":7},{"id":"GO:0006096","count":6}]},{"hash":"1227115532753611126","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":104,"triangles":205,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006120","count":2},{"id":"GO:0034553","count":2},{"id":"GO:0006450","count":2},{"id":"GO:0006429","count":2}]},{"hash":"1731508051797860767","title":"Unknown","description":"The top GO terms cover a range of tissue-specific developmental processes (retina, melanocyte, gonad, neuron migration, lymphoid development) and general post-translational modifications (ubiquitination, dephosphorylation) with no single unifying function across the cluster; the signals are sparse and there are no edges, making it hard to identify a cohesive theme.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0009651","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0002320","count":2}]},{"hash":"1799698622945088153","title":"Spliceosome-regulated RNA splicing and mRNA stability","description":"The top GO terms are dominated by RNA splicing and regulation via the spliceosome, including mRNA stabilization, suggesting a cluster of RNA-processing factors. The other terms are more heterogeneous, representing secondary roles, but the core theme remains RNA processing.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008380","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0048255","count":2},{"id":"GO:0090090","count":2}]},{"hash":"664101690203156569","title":"Neural and sensory development","description":"The GO terms point to development and connectivity of neural and sensory systems: retina layer formation, otic placode development, vestibulocochlear nerve organization, axon extension/guidance, paranode localization, and regulation of synaptic plasticity and vesicle endocytosis. A few terms relate to broader developmental processes (bone growth, angiogenesis), but the dominant theme is neural/sensory tissue development and neural connectivity.","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0010842","count":8},{"id":"GO:1900242","count":8},{"id":"GO:0048846","count":8},{"id":"GO:0006469","count":7},{"id":"GO:0048168","count":6}]},{"hash":"697377498683451780","title":"Cell Division and Development","description":"This cluster is anchored by terms for cell division and DNA replication (cell division, mitotic cell cycle, DNA replication) and development of multicellular organisms (multicellular organism development, neuron development), pointing to proliferation and differentiation roles. A subset of terms references protein quality control and trafficking (ubiquitin-dependent ERAD pathway, retrograde Golgi-ER transport, phospholipid translocation, cadmium response), which may relate to cellular remodeling during division and development. Overall, the dominant theme is cell cycle\u2013driven growth and organismal development.","confidence":"High","size":20,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0048666","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0007275","count":3}]},{"hash":"1034880622383223719","title":"BMP/SMAD signaling in bone differentiation","description":"The cluster repeatedly contains GO terms about BMP signaling and SMAD signaling regulation, along with osteoblast differentiation and ossification, and skeletal muscle differentiation, indicating a core theme of modulating BMP/SMAD pathways in bone and related differentiation processes. Some translation-related terms are present but seem secondary to the differentiation-focused signaling theme.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":5},{"id":"GO:0035914","count":5},{"id":"GO:0045668","count":4},{"id":"GO:0045603","count":4},{"id":"GO:0060212","count":4}]},{"hash":"14703143260731834","title":"LPS and Exopolysaccharide Biosynthesis","description":"The top GO terms cluster around lipopolysaccharide and O-antigen biosynthesis, colanic acid biosynthesis, and related sugar precursors (ADP-L-glycero-beta-D-manno-heptose, rhamnose), indicating a focus on bacterial cell envelope polysaccharide production rather than general metabolism. A few other metabolic terms are present but do not override the clear polysaccharide biosynthesis theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097171","count":3},{"id":"GO:0006541","count":3},{"id":"GO:0009243","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0019305","count":3}]},{"hash":"2052536195165634264","title":"Dopaminergic signaling and drug reward","description":"The cluster centers on brain neurotransmission, especially dopaminergic synaptic activity, and behavioral drug responses (cocaine, morphine), with linked signaling (ERK cascade) and sensory-perceptual functions (vision, pain). Taken together, these terms point to neuronal reward and sensory processing networks in the brain.","confidence":"High","size":20,"edges":73,"triangles":55,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":16},{"id":"GO:0071380","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0019233","count":16},{"id":"GO:0010759","count":16}]},{"hash":"1395017822711603975","title":"Organ Development and Transcriptional Regulation","description":"This cluster centers on proteins linked to multicellular development across diverse organs (inner ear, brain, retina, pituitary, somites, gonads) and includes regulators of RNA polymerase II transcription, including negative regulation, suggesting a cohesive role in organogenesis via transcriptional control.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0048839","count":9},{"id":"GO:0001757","count":8},{"id":"GO:0048935","count":8}]},{"hash":"2225610067930754836","title":"Thermoception and Vasopressin Secretion Pathway","description":"This cluster is dominated by terms related to temperature sensation and cold response (thermoception, detection of temperature stimulus, response to cold) and signals associated with calcium signaling and sensory perception, plus vasopressin secretion. While a vascular remodeling term appears, the strongest common theme ties temperature sensing with neuroendocrine signaling (vasopressin release), possibly involving TRPV1-related pathways (capsazepine response). Overall, a thermoception-driven neuroendocrine signaling cluster best fits the data.","confidence":"Medium","size":20,"edges":17,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009409","count":11},{"id":"GO:0097497","count":11},{"id":"GO:1903759","count":11},{"id":"GO:1903444","count":11},{"id":"GO:0098703","count":11}]},{"hash":"1877152458123977909","title":"Arabinogalactan protein glycosylation in seed mucilage and root hairs","description":"The top GO terms cluster around arabinogalactan protein (AGP) metabolic processes, AGP glycosylation (including hydroxyproline O-linked glycosylation), and developmental contexts like seed coat mucilage formation and root hair development, suggesting a functional group centered on AGP-associated cell surface glycosylation affecting mucilage and root hair biology. Some terms appear less directly connected (e.g., insect follicle epithelium processes), but the dominant theme is AGP glycosylation in plant development.","confidence":"Medium","size":20,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048354","count":4},{"id":"GO:0010405","count":4},{"id":"GO:0007299","count":4},{"id":"GO:0001744","count":4},{"id":"GO:0010493","count":4}]},{"hash":"1077625981694334449","title":"Neural development","description":"This cluster\u2019s top GO terms strongly point to nervous system formation, with neural tube closure, spinal cord development, and neuron projection development appearing prominently (each with multiple protein associations). While other terms like ribosome biogenesis and ER-to-Golgi transport cover general cellular processes, the recurrent neural development signals suggest a cohesive theme around nervous system development rather than housekeeping functions. Confidence in this being the core theme is moderate due to some non-neural terms present.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0035948","count":5},{"id":"GO:0007584","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0061087","count":4},{"id":"GO:0001843","count":4}]},{"hash":"1124896120777157953","title":"Ubiquitin-Dependent Proteolysis & Chromatin Regulation","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic process, with multiple entries for ubiquitination and autoubiquitination, indicating a cluster centered on protein turnover via the ubiquitin system. Histone catabolic process and chromosome passenger complex localization to the spindle midzone point to links with chromatin dynamics and mitosis. Additional terms around circadian rhythm regulation and homooligomerization suggest broader regulatory roles connected to ubiquitin-mediated control. Overall, the cluster represents proteins involved in ubiquitin-dependent degradation with connections to chromatin and cell cycle processes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0051260","count":7},{"id":"GO:0090073","count":6},{"id":"GO:0042752","count":6},{"id":"GO:0036205","count":5}]},{"hash":"2088625616858388963","title":"Craniofacial and neural crest morphogenesis","description":"The top GO terms cluster around craniofacial development (roof of mouth, odontogenesis, dentin-containing tooth), neural crest cell migration, and head-region development (midbrain, pituitary, hypothalamus), with Wnt signaling as a central pathway, indicating a cohesive program of craniofacial/neural crest\u2013derived morphogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0030901","count":7},{"id":"GO:0042475","count":6},{"id":"GO:0060021","count":6},{"id":"GO:0090190","count":6}]},{"hash":"1733858447608180269","title":"B cell signaling and cell adhesion regulation","description":"These proteins show strong representation of B cell receptor signaling and positive regulation of B cell proliferation, pointing to an immune signaling theme. Additional terms involve cell adhesion, cytoskeletal regulation (Rho signaling, adherens junction localization, cell spreading), and vesicle trafficking, suggesting a broader role in signaling and interactions at the cell surface and during trafficking. Taken together, the cluster appears to center on immune signaling with associated adhesion and trafficking regulation, hence a label focused on B cell signaling with adhesion/regulation is appropriate.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001568","count":3},{"id":"GO:0030890","count":3},{"id":"GO:1901076","count":3},{"id":"GO:0050853","count":3},{"id":"GO:1900026","count":2}]},{"hash":"2270537976069889452","title":"Developmental transcriptional regulation","description":"The top GO terms show both negative and positive regulation of transcription by RNA polymerase II, suggesting members are transcriptional regulators. Coupled with terms for midbrain and craniofacial (roof of mouth) development, biomineral tissue development, and visual perception, the cluster appears linked to gene expression control during neural/craniofacial development and morphogenesis. Additional terms like angiogenesis and plasminogen activation point to developmental tissue remodeling, though some terms (e.g., complement activation) are less central. Overall, the cluster most plausibly represents proteins involved in developmental transcriptional regulation. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0045944","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0060021","count":5},{"id":"GO:0007601","count":5}]},{"hash":"320743761427427582","title":"Embryonic development and organogenesis","description":"This cluster is dominated by developmental processes: pancreatic cell development, EMT in endocardial cushion formation, trophoblast giant cell differentiation, cartilage morphogenesis, left-right pattern formation, and endocrine system development, all pointing to embryogenesis and tissue differentiation. While a few terms relate to general cellular machinery (splicing, ribosome export, DNA replication initiation), the strongest signal centers on development and organ formation, justifying a focused label.","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":13},{"id":"GO:0003198","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0060806","count":13}]},{"hash":"312794693291844453","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045216","count":20},{"id":"GO:0060901","count":20},{"id":"GO:0071681","count":20},{"id":"GO:0032533","count":20},{"id":"GO:0060989","count":20}]},{"hash":"794027956010467217","title":"Ubiquitin-Dependent Degradation and NF-kappaB Regulation","description":"The top terms are dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, autoubiquitination, K6- and K63-linked ubiquitination, and histone catabolic process, all pointing to protein turnover and chromatin regulation via ubiquitination. Also prominent are GO terms for TNF-mediated signaling and canonical NF-kappaB signaling, indicating a functional cluster centered on ubiquitin-mediated proteolysis and modulation of NF-kappaB pathways. A few terms (e.g., V(D)J recombination, intracellular transport of viral material) are related or peripheral, but the core theme remains ubiquitin-dependent regulation of signaling and degradation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0051865","count":10},{"id":"GO:0036205","count":9},{"id":"GO:0085020","count":9},{"id":"GO:1903265","count":9}]},{"hash":"754709904490383443","title":"Metabolic and Immune Cell Signaling","description":"The Top Terms point to broad intracellular signaling activities (including GPCR-related signaling), with links to metabolic differentiation (fat cell/adipocyte) and immune-related processes (foam cell differentiation, NOD1 signaling, ubiquitination) and related stress responses (cold, hepatocyte apoptosis). This suggests a cluster of proteins involved in general signaling with ties to metabolism and immune cell fate rather than a single pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":10},{"id":"GO:0007205","count":10},{"id":"GO:0016477","count":10},{"id":"GO:2001275","count":10},{"id":"GO:0016567","count":10}]},{"hash":"1402641891335382410","title":"Rac-Mediated Actin Cytoskeleton Remodeling","description":"The top GO terms point to Rac-type small GTPase signaling and actin cytoskeleton remodeling (GTPase activity, Rac signal transduction, filopodium/podosome assembly, stress fiber and cell spreading). Endocytosis and adhesion-related processes also appear, aligning with Rac-regulated cytoskeleton dynamics and membrane trafficking. Together, these proteins likely function as a Rac-driven module controlling cytoskeletal rearrangements and cell adhesion.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0046847","count":5},{"id":"GO:1900026","count":5},{"id":"GO:0045792","count":4}]},{"hash":"148600810671508037","title":"Rho/Ras GTPase signaling and cytoskeletal remodeling","description":"The cluster is dominated by GO terms centered on small GTPases (Rho and Ras) signaling, including regulation of Rho and Ras pathways and overall small GTPase-mediated signal transduction, which aligns with cytoskeletal remodeling processes such as filopodium assembly and cell spreading. This is complemented by terms about mechanical stimulus response and cell adhesion, indicating a theme of cytoskeletal dynamics in response to environmental cues. While a few terms touch other pathways (e.g., IL-7 signaling, acetylcholine receptor signaling), the core signal transduction and structural remodeling pattern is clear.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0046580","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0016525","count":4}]},{"hash":"95670343676131955","title":"Cell Junctions and Immune Modulation","description":"The cluster is dominated by GO terms for cell adhesion (heterophilic and homophilic) and protein localization to cell junctions, indicating a core role in cell\u2013cell contacts. Immune-related terms such as regulation of NK cell\u2013mediated cytotoxicity and classical complement activation suggest concurrent immune signaling at these junctions. While there are additional terms related to bone ossification and axon guidance, the common thread appears to be cell\u2013cell adhesion with immune engagement, making this a concise label for the cluster.","confidence":"Medium","size":20,"edges":26,"triangles":3,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0007156","count":14},{"id":"GO:0043931","count":12},{"id":"GO:0002860","count":12},{"id":"GO:0051963","count":12}]},{"hash":"2291753677889440966","title":"Cell-adhesion and synapse assembly proteins","description":"These proteins cluster around cell-cell adhesion (heterophilic/homophilic) and synapse assembly/fasciculation, suggesting roles in neural/cardiac tissue adhesion and synapse organization; innate immune terms may reflect multifunctionality or annotation noise.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":13},{"id":"GO:0000187","count":13},{"id":"GO:0045087","count":12},{"id":"GO:0051965","count":12},{"id":"GO:0007156","count":12}]},{"hash":"1554366046576013223","title":"Pain and Thermoregulation with Inflammation","description":"The cluster centers on nociception and heat-related responses alongside inflammatory signaling, with terms for pain perception, temperature stimulus, thermogenesis, vascular regulation, GPCR signaling, LPS response, inflammation, coagulation, and dopaminergic synaptic transmission, indicating a coherent network linking pain, temperature homeostasis, and immune/vascular processes.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0002024","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0045907","count":15},{"id":"GO:0045986","count":15}]},{"hash":"360462253151105358","title":"Developmental and Immune Signaling Cluster","description":"The top GO terms cluster around developmental processes (heart development, placenta development), hematopoiesis, and NK T cell differentiation, with supporting signals in apoptosis and prostaglandin response. A few terms touch metabolism and transport (insulin signaling, sodium transport, hyaluronan metabolism), but the strongest recurring themes are tissue development and immune-related differentiation, suggesting the proteins function in development and immune signaling contexts.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:2001275","count":7},{"id":"GO:0008286","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0001865","count":6},{"id":"GO:0071380","count":6}]},{"hash":"623513032972195508","title":"Cardiovascular adrenergic GPCR signaling","description":"The top GO terms center on adrenergic receptor signaling, activation of adenylate cyclase, MAPK pathways, and physiological outputs like increased heart rate and blood pressure, plus dopaminergic transmission. This points to proteins involved in sympathetic regulation of cardiovascular function. The electron transport chain term likely reflects mitochondrial energy demands in cardiac cells, which complements rather than contradicts the signaling theme. Overall, the cluster seems to represent cardiovascular signaling via adrenergic GPCR pathways.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0035025","count":12},{"id":"GO:0007596","count":8}]},{"hash":"1345949919087432312","title":"Unknown","description":"The GO terms are broad and disparate (sporulation, multiple metabolic pathways, ion transport, membranous septum morphogenesis, epigenetic programming), with no single cohesive function tying the proteins together. The absence of edges and triangles, plus only partial overlaps among terms, suggests a loose or incidental association rather than a defined functional module. Therefore no precise, representative label can be assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030435","count":3},{"id":"GO:0019322","count":2},{"id":"GO:0006740","count":2},{"id":"GO:0046487","count":2},{"id":"GO:0055114","count":2}]},{"hash":"793733825166111412","title":"Glutamatergic Synaptic Signaling and Brain Development","description":"This cluster is dominated by GO terms tied to brain development and excitatory synaptic function, especially glutamatergic transmission, EPSPs, and innervation, suggesting a core role in glutamatergic synapse formation and signaling in the brain. Some terms reflect broader signaling modulation (Rho, lipid phosphorylation) or ancillary pathways (morphine response, NF-kappaB), but the central theme remains neuronal connectivity and synaptic activity.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043278","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0051966","count":5},{"id":"GO:0060384","count":5}]},{"hash":"1864305069548660765","title":"Dopaminergic synaptic signaling and cocaine response","description":"Most terms point to nervous system function: visual perception/learning, nervous system development, and dopaminergic synaptic transmission, with signaling via ERK and a behavioral response to cocaine. A couple of terms (heart development, macrophage chemotaxis) are more general or cross-cutting and don't define the cluster, but they don't override the neural theme. Overall, the label reflects dopaminergic neural signaling and cocaine-responsive plasticity.","confidence":"Medium","size":19,"edges":161,"triangles":819,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":15},{"id":"GO:0071380","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0010759","count":12}]},{"hash":"424802681811334468","title":"Lung branching morphogenesis and ECM remodeling","description":"Top terms point to epithelial tube branching in lung morphogenesis and basement membrane disassembly, suggesting a developmental/structural function. The inclusion of bradykinin and neuropeptide catabolic processes, along with regulation of catalytic activity, supports a theme of proteolysis and extracellular matrix turnover tied to morphogenesis. A couple of terms (decidualization, T cell cytotoxicity) are less obviously related and may reflect broader GO annotations; overall the cluster seems centered on lung development with associated ECM remodeling and peptide catabolism.","confidence":"Medium","size":19,"edges":141,"triangles":571,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":10},{"id":"GO:0046697","count":10},{"id":"GO:0060448","count":10},{"id":"GO:0001913","count":10},{"id":"GO:0050790","count":10}]},{"hash":"2165797165173316241","title":"RNA Processing and Translation Initiation","description":"This cluster centers on RNA processing steps (splicing, alternative splicing, splice-site recognition, polyadenylation, mRNA modification) and components of translation initiation (preinitiation complex formation, eIF4F complex assembly), plus regulation of mRNA stability under stress. Taken together, the proteins appear to function in post-transcriptional regulation of gene expression, linking RNA maturation to the initiation of translation.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":18},{"id":"GO:0045292","count":17},{"id":"GO:0006378","count":17},{"id":"GO:0016556","count":16},{"id":"GO:0001731","count":16}]},{"hash":"1567340004319555341","title":"Regulated cellular signaling and metabolism","description":"This cluster\u2019s top terms concentrate on regulation of signaling activities (positive regulation of kinase and GTPase activity) and catalytic activity, with broader connections to DNA replication regulation, ciliary docking, protein turnover, ECM remodeling, amino acid response, ceramide metabolism, and nuclear import\u2014pointing to coordinated regulatory control of signaling and cellular remodeling/metabolism.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033674","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006275","count":2},{"id":"GO:0097711","count":2},{"id":"GO:0050790","count":2}]},{"hash":"1861560252003489629","title":"UV-induced DNA repair and transcription regulation","description":"The cluster centers on UV-related damage response and nucleotide-excision repair (transcription-coupled NER and pyrimidine dimer repair), plus regulation of transcription and cell cycle\u2014together pointing to a coherent theme of UV-induced DNA damage repair coupled with transcriptional control. Some developmental terms may reflect broader regulatory roles of involved proteins, but the dominant signal is DNA repair and transcription regulation in response to UV damage.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":2},{"id":"GO:0061178","count":2},{"id":"GO:0010224","count":2},{"id":"GO:0006283","count":2},{"id":"GO:0010225","count":2}]},{"hash":"854108232027247174","title":"Actin Cytoskeleton Remodeling","description":"The top terms are dominated by actin-related processes: dendritic spine morphogenesis, lamellipodium morphogenesis, actin filament polymerization, and ruffle assembly, with supporting roles in barbed-end capping and tight junction assembly. These point to dynamic actin remodeling as the core function of this cluster, with transcription-related terms playing a minor secondary role.","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1132974685653740027","title":"Inner ear and neuromast morphogenesis","description":"This cluster is dominated by terms tied to morphogenesis and sensory organ development of inner ear structures and neuromasts (lateral line), including semicircular canal morphogenesis, inner ear morphogenesis, neuromast development, and sensory perception of sound. The co-occurrence of Wnt and integrin signaling terms suggests these proteins participate in developmental signaling and cell adhesion during these morphogenetic processes, supporting a cohesive inner ear/neuromast morphogenesis theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0060670","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0002038","count":1},{"id":"GO:0048752","count":1}]},{"hash":"2144948046631570699","title":"Neural development and axon guidance","description":"The cluster is enriched in GO terms relating to neural development and axon guidance: protein localization to paranode region of axon, neurogenesis, interneuron migration, and adhesion/Rho signaling that modulate cytoskeletal dynamics and cell movement. A few terms such as lipopolysaccharide response and skeletal development appear peripheral, but the dominant pattern supports a role in neuron formation and axonal patterning.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002175","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0042517","count":5},{"id":"GO:0035023","count":5}]},{"hash":"656689431338780774","title":"Neural Development and Visual Learning","description":"The cluster is enriched for nervous system development, visual learning, and axon extension terms (nervous system development, positive regulation of axon extension, visual learning), suggesting a neural development/visual processing theme. While there are immune-related terms (e.g., cellular response to lipopolysaccharide, T cell receptor signaling), the strongest signals point to neural development and visual processing pathways, with supporting PI3K/AKT signaling involvement. This pattern supports a neural-function-centric interpretation with some multifunctional proteins.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0097011","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0006006","count":3}]},{"hash":"14761472995398158","title":"mRNA splicing and translation initiation","description":"This cluster is enriched for spliceosome-mediated mRNA processing (splicing, polyadenylation, mRNA modification) and for components related to translation initiation (preinitiation complex formation, eIF4F complex assembly), suggesting coordinated roles in mRNA maturation and initiation of translation.","confidence":"High","size":19,"edges":108,"triangles":310,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":12},{"id":"GO:0045292","count":12},{"id":"GO:0031047","count":12},{"id":"GO:0006378","count":12},{"id":"GO:0016556","count":10}]},{"hash":"2174274190450514223","title":"DNA replication and cell cycle machinery","description":"Dominant GO terms are DNA replication, mitotic cell cycle, DNA-templated transcription, and DNA repair, pointing to nuclear processes coordinating genome duplication and upkeep. Although a few entries touch on signaling or other processes, the strongest signal ties to replication and cell-cycle control, suggesting this cluster represents core DNA replication and cell-cycle machinery.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":19},{"id":"GO:0000278","count":18},{"id":"GO:0006351","count":18},{"id":"GO:0006281","count":18},{"id":"GO:0048679","count":16}]},{"hash":"2127748996731164082","title":"Widespread developmental signaling and tissue differentiation","description":"Top GO terms span multiple developmental processes across tissues (amygdala development, placenta development, enamel mineralization, lymphatic endothelial fate) and related signaling pathways (estrogen stimulus response, nuclear receptor\u2013mediated bile acid signaling). This pattern suggests a broad developmental/differentiation theme rather than a single, unified function, so a general label is appropriate.","confidence":"Medium","size":19,"edges":91,"triangles":178,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":19},{"id":"GO:0035180","count":19},{"id":"GO:0071391","count":19},{"id":"GO:0060005","count":19},{"id":"GO:0001893","count":19}]},{"hash":"1337210799896313525","title":"Neural development and MAPK/Wnt signaling","description":"Top GO terms highlight nervous system development and regulation of ERK/JNK cascades, alongside Wnt and PI3K/AKT signaling, as well as heart development. This pattern points to proteins that coordinate neural differentiation and development through interconnected signaling hubs, likely acting as regulators of multiple pathways rather than single-function effectors. The presence of terms related to T cell receptor signaling and apoptosis suggests broader signaling roles or cross-talk within this cluster.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":10},{"id":"GO:0070374","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0010765","count":7},{"id":"GO:0046330","count":7}]},{"hash":"2280376580852041074","title":"Neural and cardiac development","description":"The top GO terms cluster around neural lineage specification and maturation (subpallium neuron fate commitment, oligodendrocyte development, auditory receptor cell fate determination, regulation of subpallium differentiation) and cardiac morphogenesis (sinus venosus morphogenesis, endocardial cushion to mesenchymal transition for heart valve formation). While a humoral immune response term appears, the dominant pattern points to embryonic development across neural and heart tissues, making this a cohesive neural-cardiac development cluster.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0060163","count":19},{"id":"GO:2000981","count":19},{"id":"GO:2000802","count":19},{"id":"GO:0014003","count":19},{"id":"GO:0006959","count":19}]},{"hash":"1047834228066409363","title":"Neuronal spine morphogenesis and synaptic plasticity","description":"The top GO terms point to actin cytoskeleton remodeling in dendritic spines and synapse structural plasticity (regulation of Rho signaling, spine morphogenesis, and synaptic plasticity). The presence of sensory perception of sound suggests involvement of auditory neurons, which aligns with spine remodeling in synaptic transmission. While some terms touch on broader cell polarity or metabolism, the dominant signal is neuronal spine formation and synaptic plasticity. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0051835","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0060997","count":4},{"id":"GO:0006508","count":4}]},{"hash":"1985489872429177791","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000447","count":3},{"id":"GO:0060528","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0070306","count":3}]},{"hash":"874400055529451701","title":"Developmental ECM remodeling and coagulation","description":"The cluster includes terms for midbrain and inner ear development, biomineral tissue development, collagen catabolic processes, and complement activation with blood coagulation, suggesting a functional theme of tissue development linked to extracellular matrix remodeling and immune/coagulation pathways; a few transcription regulation terms appear incidental.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0007596","count":6}]},{"hash":"1830422879790138399","title":"Calcium-Dependent Vesicle Trafficking","description":"The top GO terms cluster around intracellular protein transport and calcium-responsive exocytosis events (e.g., acrosome reaction and long-term synaptic potentiation), pointing to vesicle trafficking regulated by calcium. Additional terms on Rho signaling and transcription modulation suggest cytoskeletal dynamics and gene regulation accompanying secretory processes, while terms on degranulation and vessel remodeling reflect broader secretory regulation. Overall, this cluster most likely represents calcium-controlled vesicle movement and exocytosis mechanisms.","confidence":"Medium","size":19,"edges":153,"triangles":700,"max_degree":18,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":6},{"id":"GO:0002692","count":5},{"id":"GO:0043314","count":5},{"id":"GO:0060313","count":5},{"id":"GO:0007340","count":5}]},{"hash":"1274503880385314263","title":"Embryonic tissue development and organogenesis","description":"The terms cluster around developmental processes across multiple organs and tissues (hindbrain rhombomere, somite specification, peripheral nervous system and basal ganglia development, kidney ureteric bud branching), indicating broad embryonic patterning and organ formation rather than a single pathway.","confidence":"Medium","size":19,"edges":14,"triangles":1,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021570","count":19},{"id":"GO:2000288","count":19},{"id":"GO:0060163","count":19},{"id":"GO:0021723","count":19},{"id":"GO:0001757","count":19}]},{"hash":"1484057930358081897","title":"Epigenetic Regulation of Embryonic Development","description":"This cluster centers on chromatin remodeling and transcriptional control, with GO terms for negative regulation of RNA polymerase II transcription and histone modification, together with multiple embryonic organogenesis terms (pancreas development, digestive tract morphogenesis, heart atrial septum morphology, neural crest migration). The mixture suggests proteins involved in epigenetic regulation that guide embryonic development across tissues.","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0043044","count":7},{"id":"GO:0031018","count":7},{"id":"GO:0048557","count":6},{"id":"GO:0003290","count":6}]},{"hash":"225927196605948087","title":"Complement and Coagulation with Angiogenesis","description":"The cluster shows strong enrichment for complement activation (classical and lectin), blood coagulation, and positive regulation of angiogenesis with endothelial barrier establishment, suggesting a vascular-immune remodeling theme. Developmental terms are present but less representative, so the core signal centers on immune/coagulation and angiogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0006958","count":10},{"id":"GO:0030901","count":10},{"id":"GO:0007596","count":10},{"id":"GO:0001867","count":9}]},{"hash":"782001345773607476","title":"Actin Remodeling and ER-Golgi Trafficking","description":"The top GO terms show a strong emphasis on actin cytoskeleton dynamics (lamellipodium morphogenesis, actin polymerization, nucleation, barbed-end capping, and bundle assembly) together with vesicle trafficking between the ER and Golgi (COPII cargo loading and ER-Golgi transport). This suggests a functional cluster centered on coordinated actin-driven remodeling and secretory pathway activity, with some signaling links (e.g., hepatocyte growth factor stimulus) and a minor immune-related term. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070317","count":2},{"id":"GO:2000394","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0030041","count":2},{"id":"GO:0090110","count":2}]},{"hash":"1260678800765734252","title":"Immune-cell actin remodeling and signaling","description":"The cluster is enriched for actin cytoskeleton assembly processes (microspike, lamellipodium, podosome) and Rho signaling, alongside immune pathways (B cell receptor signaling, innate/adaptive immune responses, IL-2 production). This combination suggests proteins coordinating cytoskeletal dynamics with immune receptor signaling and activation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030035","count":5},{"id":"GO:0050853","count":5},{"id":"GO:1900042","count":5},{"id":"GO:0030032","count":4},{"id":"GO:0043552","count":4}]},{"hash":"591104539117987793","title":"Rho GTPase\u2013Mediated Actin Dynamics","description":"This cluster centers on Rho GTPase signaling and actin cytoskeleton remodeling, with strong representation of actin organization and filament assembly, along with components of small GTPase signaling, endocytosis, and cell polarity. The inclusion of B cell receptor signaling and heart development likely reflects broader roles of these pathways across cell types, but the core theme remains Rho-regulated actin dynamics.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":8},{"id":"GO:0030036","count":8},{"id":"GO:0050853","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0043552","count":7}]},{"hash":"2296017318204656845","title":"Actin Cytoskeleton Remodeling and Rho Signaling","description":"This cluster is dominated by GO terms pointing to actin cytoskeleton dynamics and signaling, including actin reorganization, Rho GTPase\u2013mediated signaling, phosphatidylinositol signaling, and microspike assembly. While some terms pertain to broader developmental processes, the common thread appears to be coordination of actin architecture through Rho/GTPase and PI pathways, suggesting a function in cytoskeleton remodeling. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0048015","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0035023","count":4}]},{"hash":"2183646325735906794","title":"Immune signaling and actin cytoskeleton remodeling","description":"The top GO terms point to both innate and adaptive immune signaling (neutrophil chemotaxis, T cell receptor signaling, B cell affinity maturation, NK T cell differentiation, EGFR signaling) as well as cytoskeletal dynamics (regulation of Rho and Rac, microspike assembly) and phagocytosis. Together these suggest a cohesive cluster of proteins that coordinate immune signaling with actin-driven cell movement and engulfment.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0098761","count":3},{"id":"GO:0035020","count":3},{"id":"GO:0006909","count":3}]},{"hash":"1918989053926988951","title":"Innate Immunity and Host-Pathogen Interaction","description":"The GO terms cluster around innate immune defense (complement activation, innate immune response, NK cell\u2013mediated cytotoxicity, macrophage regulation) and interactions at the host\u2013pathogen interface (symbiont/virion entry, cell adhesion, immune synapse formation, and localization to cell junctions), suggesting a cohesive theme of immune defense and pathogen interaction.","confidence":"High","size":19,"edges":109,"triangles":296,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":12},{"id":"GO:0007157","count":12},{"id":"GO:0045087","count":12},{"id":"GO:0046718","count":12},{"id":"GO:0043031","count":12}]},{"hash":"2296010033187943735","title":"Unknown","description":"The top GO terms span cytoskeletal dynamics (nuclear migration along microfilament; mitotic spindle assembly), vesicle trafficking (exocytosis), signaling (Wnt pathway; RhoGEF regulation), RNA modification (m7G methylation), and muscle adaptation responses, with no single pathway or function dominating. The annotations are heterogeneous and include obsolete terms, offering little cohesive signal to define a specific biological role for the cluster. Therefore, no coherent label can be assigned beyond Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031022","count":2},{"id":"GO:0090286","count":2},{"id":"GO:2001108","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0016055","count":2}]},{"hash":"899910411711189638","title":"Neuronal signaling and synaptic activity","description":"This cluster is dominated by neural communication terms, including neuronal action potential propagation, excitatory postsynaptic potential, and regulation of glutamatergic synaptic transmission, suggesting a core function in neural signaling. There are additional terms relating to redox balance, vascular and immune processes, but the neural-related terms are the most frequent, giving a plausible but not exclusive neural theme. Confidence: Medium","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0043534","count":2},{"id":"GO:0003093","count":2},{"id":"GO:0051966","count":2}]},{"hash":"2232883682765607111","title":"Dopaminergic sensory perception and reward signaling","description":"The cluster is dominated by neural-related GO terms: sensory perception (pain/vision), dopaminergic synaptic transmission, and behavioral responses to cocaine, along with ERK cascade regulation typical of neuronal signaling and learning. This points to a brain-focused module involved in sensory processing and reward pathways, with a few outliers (e.g., heart development) that are less central to the core function.","confidence":"High","size":19,"edges":124,"triangles":372,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0071380","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0010759","count":16},{"id":"GO:0008542","count":16}]},{"hash":"122852886038274323","title":"Adrenergic signaling and cardiovascular regulation","description":"The top GO terms cluster around GPCR-mediated adrenergic signaling (adenylate cyclase activation, MAPK pathways), with physiological readouts such as increased blood pressure and heart rate, plus dopaminergic synaptic transmission. This suggests a shared function in sympathetic signaling controlling cardiovascular responses, with other terms like xenobiotic response and electron transport being less central. ","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":18},{"id":"GO:0007190","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0001963","count":17}]},{"hash":"1805899709582014527","title":"Ubiquitin-Dependent Immune Signaling","description":"The cluster is characterized by GO terms tied to ubiquitination processes (ubiquitin-dependent protein catabolic process, protein and polyubiquitination, K6-linked ubiquitination) together with immune functions (innate and adaptive immune responses, defense against virus) and signaling regulation (I-kappaB phosphorylation). This suggests proteins coordinating immune signaling through ubiquitin tagging, rather than a single physical pathway, even though there are no reported edges among these proteins.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0000209","count":6}]},{"hash":"1773811773925678622","title":"Immune signaling and tissue remodeling","description":"These proteins show both innate immune signaling (interferon pathway, innate immunity) and processes related to tissue structure (collagen fibril organization, epithelial polarity), as well as cell movement and cytoskeletal regulation (cell migration, Rho signaling). The recurring theme is coordination between immune signaling and tissue remodeling/development across several tissues (bone, myelination). So \"Immune signaling and tissue remodeling\" fits best.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060335","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0071260","count":3},{"id":"GO:1902499","count":3},{"id":"GO:0045087","count":3}]},{"hash":"2242548620946883652","title":"Epithelial polarity and microvilli/brush border assembly","description":"The proteins here cluster around epithelial cell polarity and apical/basal organization, including establishment of epithelial polarity, tight junction/bicellular junction assembly, and assembly of microvilli and brush border structures, with centrosome localization also tied to polarity. Some terms (e.g., photoreceptor differentiation, synapse plasticity) are less directly related, but the dominant theme is epithelial cell architecture and apical surface formation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0045198","count":5},{"id":"GO:0051835","count":5},{"id":"GO:0010718","count":4},{"id":"GO:0043622","count":4},{"id":"GO:0001751","count":4}]},{"hash":"310459989496333635","title":"Synaptic signaling and neuronal development","description":"The set of top GO terms is dominated by processes related to synapse formation and function (dendritic spine morphogenesis, protein localization to synapse, receptor clustering, and potassium ion transport), which point to neuronal signaling and synaptic organization as the core theme of this cluster. Additional terms touch on broader regulatory pathways (Wnt signaling, cell proliferation and apoptosis, centrosome dynamics) that may reflect shared signaling networks or pleiotropy, but the strongest and most cohesive signal centers on synaptic development and neural signaling.","confidence":"Medium","size":18,"edges":14,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007100","count":15},{"id":"GO:0006915","count":15},{"id":"GO:0008285","count":15},{"id":"GO:0060044","count":15},{"id":"GO:0090263","count":15}]},{"hash":"1941519754089934497","title":"Cardiac calcium signaling and conduction","description":"This cluster is dominated by GO terms related to calcium handling and cardiac electrical signaling, including release of Ca2+ from the sarcoplasmic reticulum, Purkinje-to-ventricular signaling, and regulation of AV node action potentials, with supporting signals from cAMP pathways and general stress responses (autophagy, NF-kappaB). While some terms touch on immune or xenobiotic responses, the strongest and most coherent theme centers on cardiac calcium dynamics and conduction. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007586","count":4},{"id":"GO:0014808","count":3},{"id":"GO:0016540","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0051591","count":3}]},{"hash":"70237777676202869","title":"Axon Guidance and Neural Crest Migration","description":"The top GO terms cluster around neuronal development, specifically axon guidance and neural crest migration (branchiomotor and sympathetic neuron guidance, trigeminal nerve organization, semaphorin-plexin signaling). Additional terms on cell adhesion and related signaling indicate the guidance and organization context for migrating neurons. Thus, the dominant theme is neural pathfinding and neural crest\u2013derived neuron wiring.","confidence":"High","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0021785","count":4},{"id":"GO:0036486","count":4},{"id":"GO:0097491","count":4},{"id":"GO:0021637","count":4},{"id":"GO:0097490","count":4}]},{"hash":"1969486587311964353","title":"Mitotic Regulation and DNA Damage Response","description":"The dominant terms emphasize mitosis (mitotic cell cycle, G1 DNA damage checkpoint signaling, kinetochore localization) and genome maintenance (DNA replication and repair, CDK activity regulation, and proliferation control). A cadmium stress term appears but is secondary; overall this cluster maps to a cohesive module coordinating chromosome segregation and genome integrity during cell division.","confidence":"High","size":18,"edges":20,"triangles":8,"max_degree":6,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034501","count":15},{"id":"GO:0045736","count":15},{"id":"GO:0008285","count":13},{"id":"GO:0000278","count":13},{"id":"GO:0051436","count":13}]},{"hash":"966433645178691438","title":"Lymphocyte differentiation and signaling","description":"The proteins are enriched for immune-related processes: NK T cell differentiation, B cell affinity maturation, interleukin-4 production, and hemopoiesis, indicating lymphoid development. Also, lamellipodium assembly and regulation of Rho/Ras signaling suggest cytoskeletal dynamics and signaling tied to immune cell migration and activation, supporting a cohesive theme of immune cell differentiation and signaling. Some terms like CNS development are ancillary, but the immune-focused terms prevail.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:2001275","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0048009","count":7},{"id":"GO:0001865","count":7},{"id":"GO:0007417","count":7}]},{"hash":"1104591472028979299","title":"Dopaminergic Neural Signaling and Cocaine Response","description":"The cluster is dominated by brain-related GO terms: dopaminergic synaptic transmission, visual perception and learning, sensory perception of pain, and behavioral response to cocaine, suggesting a cohesive theme of neuronal signaling and drug response. ERK1/ERK2 cascade regulation supports signaling pathways in neurons, while prostaglandin stimulus can modulate neural activity. A few terms (macrophage chemotaxis, heart development) are peripheral, but the central pattern points to neural communication and cocaine-related behavior.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0010759","count":12},{"id":"GO:0008542","count":12}]},{"hash":"1321278585344827372","title":"Ubiquitin-Dependent Proteolysis, Innate Immunity, and Actin Remodeling","description":"This cluster centers on ubiquitin-dependent protein turnover (ubiquitination, SCF-proteasome pathways, ERAD) and its links to innate antiviral defense (defense response to virus, innate immune response). It also includes actin cytoskeleton dynamics (actin filament network formation and severing), suggesting coordinated regulation of proteostasis, immunity, and cytoskeletal remodeling.","confidence":"Medium","size":18,"edges":10,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0051639","count":4},{"id":"GO:0030433","count":3}]},{"hash":"1657538008458062208","title":"Unknown","description":"Top terms are highly heterogeneous, spanning mitochondrial import, redox processes, xenobiotic response, detoxification, metabolism, and diverse developmental processes, with several obsolete terms. There is no single coherent function unifying the cluster, so no reliable, representative label can be assigned. Confidence: None","confidence":"","size":18,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0030150","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0042208","count":2}]},{"hash":"981809279068811292","title":"Developmental Processes and Steroid Biosynthesis","description":"The terms cluster around development in several organs (heart, retina, female gonad) and steroid biosynthesis (aldosterone, cortisol), with supporting processes like apoptosis and cell cycle. The common thread is developmental/differentiation activities linked to hormone production, justifying a label that reflects both developmental and endocrine aspects without pinning to one specific organ.","confidence":"Medium","size":18,"edges":5,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0008585","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0000278","count":3}]},{"hash":"2224032499684951348","title":"Neuronal Development and Signaling","description":"This cluster centers on brain development and neural signaling, with prominent terms for nervous system development, substantia nigra and hippocampus development, and signaling pathways like Roundabout (Slit-Robo), GPCR signaling, and ERK cascade regulation. Neuron maturation and NF-kappaB regulation further support neural differentiation and neuromodulatory signaling, while a TH1 immune term and mechanical stimulus response may reflect broader neuroimmune and mechanotransduction contexts. Overall, the theme best fits neural development and signaling programs.","confidence":"Medium","size":18,"edges":62,"triangles":19,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0035385","count":8},{"id":"GO:0042088","count":7},{"id":"GO:0071260","count":7}]},{"hash":"112615078072997886","title":"Embryonic organ morphogenesis and transcription regulation","description":"It centers on embryonic organ morphogenesis (lung, pancreas, ureteric bud) and neural crest migration, with strong links to transcriptional regulation and chromatin remodeling, suggesting coordinated gene expression control during development.","confidence":"High","size":18,"edges":96,"triangles":242,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0048557","count":7},{"id":"GO:0060441","count":7},{"id":"GO:0090190","count":7},{"id":"GO:0001755","count":7}]},{"hash":"2067343397991613389","title":"Developmental transcriptional regulation","description":"GO terms cluster around DNA-templated transcription and RNAP II activity, coupled with differentiation of osteoblasts, chondrocytes, skeletal muscle, endocardial, and craniofacial tissues, and SMAD/TGF-beta signaling. This suggests the proteins act together to coordinate development through transcriptional control and signaling pathways.","confidence":"High","size":18,"edges":140,"triangles":631,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0045669","count":7},{"id":"GO:0006366","count":7},{"id":"GO:0035914","count":6},{"id":"GO:0060395","count":6}]},{"hash":"887155636197465437","title":"Vitamin, sugar, and xenobiotic transmembrane transporters","description":"These terms show a strong emphasis on transmembrane transport across diverse substrates: vitamins (GO:0035461), xenobiotics (GO:0006855, GO:0042908), sugars (D-glucose GO:1904659, trehalose GO:0015771), potassium ions (GO:0071805), and even neurotransmitter loading into synaptic vesicles (GO:0098700), pointing to a cohesive set of membrane transporter proteins handling nutrient uptake and detoxification. The presence of a neuron-related vesicle term suggests related transport and sorting mechanisms in specialized cells, but the overarching theme remains membrane transport. The cluster is best described as a group of transporters for vitamins, sugars, and xenobiotics, with ancillary substrate- and vesicle-related transport roles. ","confidence":"High","size":18,"edges":25,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":18},{"id":"GO:0006855","count":18},{"id":"GO:0042891","count":17},{"id":"GO:0071805","count":15},{"id":"GO:0042908","count":15}]},{"hash":"1200745560220401111","title":"Neurodevelopment and Synaptic Assembly","description":"This cluster is dominated by neural-related terms: forebrain development, synaptic assembly at neuromuscular junction, sensory perception of sound, and cellular response to nerve growth factor stimulus, plus neural tube patterning. These suggest a theme centered on nervous system development and synaptic connectivity, with additional ECM/cholesterol-related terms that may reflect shared tissue remodeling and lipid metabolism during development. Confidence: Medium","confidence":"","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:1990090","count":3},{"id":"GO:0051124","count":3},{"id":"GO:0008203","count":3},{"id":"GO:0030198","count":3}]},{"hash":"1853167672857672602","title":"Retinoid metabolism and craniofacial development","description":"The top GO terms cluster around retinoid biology (retinal metabolic process, retinol metabolic process, 9-cis-retinoic acid biosynthetic process) and developmental processes including face development, pituitary gland development, blood vessel/endothelial proliferation regulation, and bilateral symmetry determination, suggesting a coherent role for retinoid signaling in eye and craniofacial morphogenesis and related development. The obsolete glutamate biosynthetic term appears incidental. Confidence: High.","confidence":"","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":18},{"id":"GO:0042572","count":18},{"id":"GO:0006537","count":17},{"id":"GO:0001568","count":17},{"id":"GO:0009855","count":17}]},{"hash":"2302618629582437903","title":"Developmental morphogenesis and organ differentiation","description":"The top GO terms cluster around embryonic development and organ formation: metanephric renal vesicle morphogenesis, paramesonephric duct development, atrial cardiac muscle cell differentiation, and angiogenesis, with supporting terms like cell-cell junction organization that relate to tissue morphogenesis. Some terms (oxidation-reduction, antibiotic response, platelet aggregation) appear as outliers or broader annotations, suggesting noise. Overall, the dominant theme is developmental morphogenesis and organ specification, so this label captures the cluster best. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0097477","count":5},{"id":"GO:0070527","count":5},{"id":"GO:0042619","count":5},{"id":"GO:0045766","count":5}]},{"hash":"60413225164108268","title":"Oxidative Stress Response and Detoxification","description":"Dominant GO terms show redox homeostasis and oxidant detoxification, pointing to proteins involved in managing reactive oxygen species and detox processes. While other terms indicate growth signaling, calcium-channel regulation, and transport, the redox-related terms are most prevalent, suggesting the cluster centers on cellular defense against oxidative stress and detoxification, with accompanying signaling roles.","confidence":"High","size":18,"edges":136,"triangles":617,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":12},{"id":"GO:0098869","count":11},{"id":"GO:0071364","count":7},{"id":"GO:0070527","count":7},{"id":"GO:1902476","count":7}]},{"hash":"776834543913821281","title":"Embryonic organogenesis and sensory development","description":"The set includes genes involved in multiple organ development programs (inner ear, eye, pharyngeal system, gonads, uterus, ureteric bud) and sensory-related processes (visual perception, lens differentiation). The concurrent enrichment for transcriptional regulation by RNA Pol II suggests coordinated control of gene expression during development. Together, these terms point to a broad developmental/sensory organogenesis theme rather than a single specific pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0048839","count":4},{"id":"GO:0072107","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0060037","count":3}]},{"hash":"1247631598989136434","title":"Epithelial polarity and cell junction assembly","description":"The cluster features GO terms tied to establishing epithelial apical/basal polarity, tight and adherens junction assembly/localization, basolateral membrane targeting, and microvillus assembly, all pointing to coordinated epithelial cell organization and membrane domain formation. Regulation of Rho signaling also supports cytoskeletal dynamics essential for junction integrity, making this a coherent theme.","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0035023","count":8},{"id":"GO:0070830","count":8},{"id":"GO:0051835","count":8},{"id":"GO:0051660","count":8},{"id":"GO:1903361","count":6}]},{"hash":"1516529517160618705","title":"Vascular adhesion and endothelial signaling","description":"The top GO terms cluster around regulation of cell adhesion (substrate- and cell-cell), vascular biology (glomerulus vasculature development, endothelial migration), and platelet activation, pointing to a module involved in blood vessel formation and vascular-platelet interactions. Immune signaling terms (pattern recognition receptor signaling and cytokine regulation) add a contextual layer of immune modulation within the vascular arena. Overall, these terms converge on vascular adhesion and signaling processes, though some immune-related terms may reflect broader context. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010812","count":4},{"id":"GO:0044320","count":4},{"id":"GO:0034116","count":4},{"id":"GO:0030168","count":4},{"id":"GO:0007158","count":4}]},{"hash":"143842629756058740","title":"Embryonic development and organ morphogenesis","description":"The top GO terms cluster around developmental processes such as trophoblast giant cell differentiation, placental development, left-right patterning, cartilage morphogenesis, pancreatic cell development, and EMT in heart formation, suggesting a shared role in embryogenesis and organogenesis. Some general processes like mRNA splicing and transcription regulation appear as background cellular activities rather than core themes. This supports labeling the cluster as Embryonic development and organ morphogenesis.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":13},{"id":"GO:0060806","count":12},{"id":"GO:0060972","count":12},{"id":"GO:0060536","count":12},{"id":"GO:0003323","count":12}]},{"hash":"407084675603959542","title":"Actin Dynamics at Junctions and Synapses","description":"This cluster centers on actin cytoskeleton remodeling (actin organization, actin nucleation) with regulation by Rho signaling, plus localization/assembly at cell-cell junctions (adherens and tight junctions) and related synaptic plasticity processes. The shared theme is actin-driven structural changes that support junction integrity and synaptic/endothelial signaling, justifying the label.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0071896","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0060292","count":3}]},{"hash":"1285421728220748366","title":"Developmental transcription regulation","description":"The cluster is dominated by GO terms about RNA polymerase II\u2013mediated transcription, including both transcription activity and negative regulation, alongside multiple tissue development terms (eye, pituitary, thyroid, lung morphogenesis), suggesting proteins that regulate transcription during development across tissues.","confidence":"High","size":18,"edges":38,"triangles":9,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0006366","count":11},{"id":"GO:0021983","count":11},{"id":"GO:0060441","count":11},{"id":"GO:0043010","count":11}]},{"hash":"2096604063711026881","title":"Embryonic Development and Organogenesis","description":"The cluster features diverse developmental processes across tissues\u2014gonad, retina, neural crest, heart outflow tract, pancreas, kidney branching, and early embryonic events like primitive streak formation\u2014plus transcriptional regulation. This suggests the proteins collectively participate in broad developmental patterning and organ formation rather than a single specific pathway.","confidence":"Medium","size":18,"edges":41,"triangles":8,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0060041","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0006366","count":5}]},{"hash":"2234716868677696682","title":"Neural and Immune Signaling","description":"The top terms include insulin receptor signaling and T/B cell receptor signaling, indicating immune signaling involvement, while terms like cerebellar cortex formation, Bergmann glial differentiation, and long-term synaptic potentiation point to neural development and synaptic plasticity. Negative regulation of ERK signaling also ties these pathways together, suggesting a shared emphasis on signaling modulation across neural and immune contexts. The obsolete GO term is noted as a caveat. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0048679","count":3},{"id":"GO:0008285","count":3}]},{"hash":"28052498819506325","title":"Immune receptor signaling and leukocyte adhesion","description":"This cluster is dominated by immune signaling terms, including Fc receptor pathways (Fc-gamma and Fc-epsilon) and T cell co-stimulation and proliferation, as well as neutrophil extravasation. The presence of adhesion-related and cytoskeletal terms (cell\u2013cell adhesion, actin organization) supports a theme of leukocyte adhesion and directed migration. Overall, the proteins likely participate in immune activation and trafficking processes.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038096","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0072672","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0031295","count":4}]},{"hash":"147518118345599026","title":"Developmental Signaling and Adhesion","description":"This cluster centers on multiple signaling pathways (Rho, Wnt, KIT) and processes related to cell adhesion and development (including heart development and synaptic plasticity), suggesting a theme of coordinated signaling in developmental and cell interaction contexts rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0090263","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0038109","count":3}]},{"hash":"2284565889865048305","title":"Neuronal adhesion and synapse assembly","description":"Based on the prevalent neural development terms in the cluster\u2014axonal fasciculation, heterophilic cell\u2013cell adhesion, myelination, and regulation of synapse assembly\u2014the proteins likely participate in neural connectivity and synapse formation. Some terms are outdated or unrelated, but the dominant theme supports a neural adhesion/synapse assembly label.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":9},{"id":"GO:0007157","count":8},{"id":"GO:0046718","count":8},{"id":"GO:0014068","count":8},{"id":"GO:0042552","count":8}]},{"hash":"1950876139593760063","title":"Calcium signaling and membrane transport","description":"Top terms cluster around calcium signaling and membrane transport: calcium import across the plasma membrane and release of sequestered calcium into the cytosol, plus potassium transmembrane transport and vacuolar transport. The presence of GTPase activity regulation and spindle assembly suggests connected roles in vesicle trafficking and cytoskeletal dynamics, while ubiquitination and (obsolete) NF-kB regulation point to broader signaling control. Overall, the cluster reflects Ca2+-dependent signaling coupled to membrane transport and trafficking.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0050728","count":3},{"id":"GO:0051209","count":3}]},{"hash":"292411577197097401","title":"Development and innate immune signaling","description":"This cluster centers on GO terms for multicellular organism development and innate immune response, both frequent, alongside related signaling processes (NF-kappaB, Rho signaling) and calcium release, ossification, and nervous system development. The common thread appears to be signaling pathways that coordinate development and immune-related tissue remodeling across tissues, making \u201cDevelopment and innate immune signaling\u201d a representative, specific label.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0051092","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0043931","count":3}]},{"hash":"840457885703899568","title":"Ubiquitin-dependent immune regulation","description":"This cluster is dominated by GO terms linking protein ubiquitination processes (ubiquitin-dependent protein catabolic process; K33-linked ubiquitination) with immune functions, including innate and type 2 immune responses, germinal center formation, and regulation of dendritic cell and memory T cell differentiation. While a couple of terms reference development in other tissues, the strongest and most frequent annotations point to ubiquitin-mediated control of immune signaling and adaptive immunity, suggesting the proteins collectively participate in ubiquitin-regulated immune responses.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0002467","count":8},{"id":"GO:0045087","count":7},{"id":"GO:0042092","count":7},{"id":"GO:0045496","count":7}]},{"hash":"1128286694869927523","title":"Telomere maintenance and spindle assembly","description":"Reasoning: The top GO terms cluster around telomere maintenance and chromosome localization to telomeres, plus spindle assembly, which together point to chromosome stability during mitosis. Ubiquitination and ADP-ribosylation indicate regulation of these processes by post-translational modifications. Stress granule assembly may reflect RNA-associated components within this cluster, but it does not override the stronger signals about telomere/chromosome dynamics and mitotic machinery. Overall, the cluster seems to represent proteins involved in maintaining telomere integrity and proper chromosome segregation during cell division, with regulatory PTMs.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034063","count":3},{"id":"GO:1904908","count":2},{"id":"GO:0070198","count":2},{"id":"GO:0051225","count":2},{"id":"GO:1904357","count":2}]},{"hash":"172576608385177988","title":"Embryonic Differentiation and Organogenesis","description":"The GO terms cluster around embryonic development across multiple tissues (placental/trophoblast differentiation, left-right patterning, cartilage morphogenesis, pancreatic endocrine development, and heart-associated EMT), suggesting a focus on early differentiation and organogenesis rather than a single tissue type. A label like Embryonic Differentiation and Organogenesis fits this broad developmental theme; some transcription/splicing terms likely reflect general regulatory control during development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0060806","count":9},{"id":"GO:0060972","count":9},{"id":"GO:0060536","count":9},{"id":"GO:0003323","count":9},{"id":"GO:0003198","count":9}]},{"hash":"1857617658600793807","title":"Plant detoxification and aromatic compound metabolism","description":"The top GO terms cluster around detoxifying toxic substances and oxidant handling, plus metabolism of aromatic compounds (beta-ketoadipate pathway, alkaloid and antibiotic biosynthesis, 1,2-dichloroethane catabolism). A few terms also touch on plant development (secondary shoot formation, proliferation), suggesting a theme of detox/secondary metabolism with growth-related roles in plants. Overall, the shared thread is processing xenobiotics and aromatic metabolites in a plant context.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0009636","count":7},{"id":"GO:0098869","count":7},{"id":"GO:0042952","count":7},{"id":"GO:0008284","count":6},{"id":"GO:0055114","count":6}]},{"hash":"338034299929371773","title":"Neuronal Development and Immune-Vascular Regulation","description":"The cluster centers on neural development signals (axonogenesis, neuronal differentiation), extensive signaling modulation (signal transduction, protein kinase activity dephosphorylation), and overlapping immune/vascular regulation (innate immune response, T cell homeostasis, negative regulation of angiogenesis). The mix of neural differentiation, immune response, and vascular signaling suggests a cohesive theme of neural development coordinated with immune and vascular regulation rather than a single pathway, supporting a representative label focused on neural development with immune-vascular signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007409","count":3},{"id":"GO:0007165","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1926775397770499496","title":"Plant secondary metabolite biosynthesis and shoot development","description":"The GO terms show plant-centered biosynthesis (strigolactone, alkaloids) and secondary shoot formation, suggesting a theme of plant secondary metabolism and growth regulation, with additional detoxification and generalized metabolic processes. Some terms also indicate microbial pathways, so the connection is present but not exclusive.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0098869","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0019433","count":7},{"id":"GO:0010223","count":6}]},{"hash":"1675253343680389799","title":"Plasma Membrane Transporters","description":"The top GO terms cluster around transport across the plasma membrane for diverse substrates (glucose, trehalose, sialic acid, organic anions, selenite, etc.) and related vesicle loading, which together point to transporter proteins at the cell membrane. The presence of a single light-detection term is less connected to this theme, so the dominant pattern is membrane transport activity.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050908","count":2},{"id":"GO:1900754","count":2},{"id":"GO:0098700","count":2},{"id":"GO:1904728","count":2},{"id":"GO:1904659","count":2}]},{"hash":"405680014627584605","title":"Regulated neuronal synaptic transmission and behavior","description":"The cluster\u2019s top GO terms are dominated by neuronal signaling and synaptic transmission (regulation of short-term synaptic plasticity, excitatory postsynaptic potential, and glutamatergic transmission), complemented by terms on cerebellar granule cell differentiation and behavioral processes (phototaxis, male mating behavior). A few outliers involve metabolic processes (methanol catabolic, ectoine transport) but do not define the cluster\u2019s main theme. Overall, the data point to neuronal signaling and behavior modulation as the core function represented. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":4},{"id":"GO:0046170","count":3},{"id":"GO:0045471","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0051967","count":3}]},{"hash":"160092693734016021","title":"Developmental and Immune System Processes","description":"The top terms point to developmental roles (heart and placenta development) together with immune-related processes (NK T cell differentiation, hemopoiesis) and connective-tissue/inflammatory signals (prostaglandin response, hyaluronan metabolism, apoptosis). This suggests the cluster reflects genes involved in organ development and immune system maturation rather than a single enzymatic function, hence a developmental/immune theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:2001275","count":5},{"id":"GO:0010765","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0001865","count":4}]},{"hash":"1481920816921636579","title":"Neural development and synaptic connectivity","description":"The cluster is dominated by terms related to nervous system development, axon fasciculation, myelination, and synapse assembly/self-avoidance, indicating proteins involved in neuronal differentiation and the wiring of neural circuits. Some immune-related terms appear but seem ancillary to the main neural connectivity theme. Overall, the label reflects the central function of the group.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":13},{"id":"GO:0007413","count":13},{"id":"GO:0042552","count":12},{"id":"GO:0051965","count":12},{"id":"GO:0032474","count":12}]},{"hash":"724800833396373300","title":"Cell adhesion and neuronal signaling","description":"The top GO terms cluster around cell\u2013cell adhesion and junction assembly (tight junctions, calcium-independent adhesion, integrin signaling) and neuronal communication (glutamatergic transmission, excitatory postsynaptic potential, neuronal action potential). This suggests a core theme of adhesion machinery linked to neuronal signaling across tissues, with some terms related to vascular filtration also fitting into barrier/adhesion context. A few terms (T cell cytotoxicity, peptidoglycan catabolic process) seem less connected, likely reflecting multifunctionality in the protein set. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":4},{"id":"GO:2001046","count":3},{"id":"GO:0043534","count":2},{"id":"GO:0003093","count":2},{"id":"GO:0051966","count":2}]},{"hash":"619858675195392749","title":"Immune signaling and cell polarity regulation","description":"The top GO terms point to immune-related activity (B cell proliferation and IL-18 production) alongside processes that regulate cell architecture and signaling (cell polarity maintenance, actin filament formation, Wnt/GPCR/Rap signaling, and AMPK-CAMKK regulation). This suggests a cluster of proteins involved in modulating immune responses while coordinating cell polarity and cytoskeletal dynamics. The lack of connectivity in the graph makes the cohesion less tight, but the recurring theme across signaling and structural regulation supports this labeling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002322","count":3},{"id":"GO:0030011","count":3},{"id":"GO:0032486","count":2},{"id":"GO:0008277","count":2},{"id":"GO:0030177","count":2}]},{"hash":"1238288090858121451","title":"Unknown","description":"The top GO terms are very diverse (cholesterol biosynthesis, visual learning, response to cocaine, regulation of NFAT signaling, defense against Gram-positive bacteria, telomere maintenance, axon regeneration) with no clear common pathway or interaction linking the proteins, and there are no edges connecting them, making a cohesive functional label unlikely. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006695","count":4},{"id":"GO:0008542","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0051534","count":4},{"id":"GO:0050830","count":4}]},{"hash":"2081458296706320770","title":"Plant mitotic spindle assembly and chromosome segregation","description":"The top GO terms point to mitotic processes: spindle midzone assembly, lateral attachment of spindle microtubules to kinetochores, metaphase chromosome alignment, plus-end and general microtubule depolymerization, and mitotic metaphase chromosome recapture, indicating a cohesive theme of spindle dynamics and chromosome segregation during cell division. The presence of epidermal stem cell homeostasis and root development terms suggests this activity occurs in plant tissues, particularly in developmentally active roots. Altogether, the cluster seems best described by plant mitotic spindle assembly and chromosome segregation.","confidence":"High","size":17,"edges":133,"triangles":637,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0036334","count":11},{"id":"GO:0000742","count":11},{"id":"GO:0048364","count":11},{"id":"GO:0007080","count":11},{"id":"GO:0010938","count":11}]},{"hash":"1180893124966040654","title":"Immune Activation and Leukocyte Migration Regulation","description":"Based on the GO terms, the cluster centers on immune-related signaling and movement: T cell activation, cellular extravasation, substrate adhesion-dependent cell spreading, and hyaluronan metabolism point to leukocyte\u2013endothelial interactions and extracellular matrix remodeling. Additional terms for regulation of Rho and Ras signaling and neutrophil degranulation indicate control of cytoskeletal dynamics and vesicle-related processes (acrosome reaction, synaptic vesicle priming), consistent with regulated exocytosis and migration. Together these suggest a function group in immune cell activation and migration rather than a single enzymatic pathway.","confidence":"Medium","size":17,"edges":4,"triangles":1,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043314","count":10},{"id":"GO:0060313","count":10},{"id":"GO:0035023","count":9},{"id":"GO:0007340","count":9},{"id":"GO:0016082","count":9}]},{"hash":"2148767531262193510","title":"Neural development and synaptic signaling","description":"The cluster is dominated by terms related to nervous system development and synaptic function, including axonogenesis, Schwann cell development, visual perception, excitatory postsynaptic potential, and long-term synaptic potentiation. While there are some general cell cycle and other non-neural terms present, the neural development and synaptic signaling signals are strongest, supporting a label centered on neural growth and communication.","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":15},{"id":"GO:0060079","count":15},{"id":"GO:0014044","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0010800","count":15}]},{"hash":"1149668940710721587","title":"Signaling and cell-adhesion cluster","description":"The top GO terms point to a mix of signaling pathway regulation (NFAT/calcineurin, PI3K/AKT, Hippo, SMAD turnover) along with cell-matrix adhesion. This suggests a group of proteins that coordinate signaling cascades with adhesion-related processes, rather than a single, cohesive pathway. Some terms appear peripheral (thyroid hormone response, LPS biosynthesis), likely due to annotation noise, but the central theme is signaling regulation paired with adhesion.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070886","count":6},{"id":"GO:0097067","count":5},{"id":"GO:0046013","count":5},{"id":"GO:0030579","count":5},{"id":"GO:0007160","count":5}]},{"hash":"351750298606266414","title":"Unknown","description":"The GO terms span neural development (axonogenesis, corpus callosum development), immune signaling (innate immune response, lipopolysaccharide signaling), and general cellular processes (DNA replication, nuclear export). This mixture does not reveal a single, cohesive function or pathway for the cluster, so a clear, specific label isn\u2019t evident.","confidence":"","size":17,"edges":28,"triangles":6,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007409","count":4},{"id":"GO:0000742","count":3},{"id":"GO:0006260","count":3},{"id":"GO:1903351","count":3},{"id":"GO:0014068","count":3}]},{"hash":"1342909499898541917","title":"Stress-Responsive Chromatin Regulation","description":"The cluster shows enrichment for stress-related responses (response to morphine, interferon-alpha, hydrogen peroxide) and chromatin-associated processes (RNA polymerase III transcription, histone methylation/dephosphorylation). This combination suggests proteins involved in sensing or responding to cellular stress and coordinating gene expression through chromatin remodeling, despite some terms being obsolete. ","confidence":"Medium","size":17,"edges":113,"triangles":446,"max_degree":16,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0043278","count":5},{"id":"GO:0070389","count":4},{"id":"GO:0035457","count":4},{"id":"GO:0070301","count":4},{"id":"GO:0001041","count":4}]},{"hash":"383050558108952608","title":"Dopaminergic signaling and neuronal drug response","description":"This cluster centers on dopaminergic synaptic transmission and behavioral responses to cocaine, with supporting terms in learning and GPCR-mediated signaling (ERK cascade, adenylate cyclase). The presence of pain/temperature-related terms suggests a broader neuronal sensory/regulatory role, linking reward signaling to sensory and thermogenic contexts. Altogether, the theme best fits dopamine-driven neural signaling and plasticity in response to drugs and sensory cues.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0002024","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0001963","count":11},{"id":"GO:0022900","count":11}]},{"hash":"1798340234210631587","title":"Transcription Regulation and Cardiac Development","description":"The cluster shows enrichment for DNA-templated transcription and mRNA processing, with additional terms linked to transcription factor activity regulation and development (notably heart development) as well as cell migration. This suggests a group of proteins involved in controlling gene expression with related roles in developmental processes, particularly cardiac development. Some terms are obsolete, and there are no network edges, indicating a loosely connected set rather than a tightly cohesive pathway cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:2001275","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0007094","count":2},{"id":"GO:0045736","count":2}]},{"hash":"294534366341158790","title":"Retinoid and Fructose Metabolism with Oxidative Stress Response","description":"The top GO terms point to retinol and retinal metabolic processes, along with fructose biosynthesis, and there are clear signals related to oxidative stress (response to hydrogen peroxide) and calcium signaling, plus apoptosis regulation. This suggests a cluster centered on metabolism of retinoids and simple sugars combined with stress-response signaling pathways that influence cell survival. ","confidence":"Medium","size":17,"edges":133,"triangles":636,"max_degree":16,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0046370","count":11},{"id":"GO:0042572","count":11},{"id":"GO:0055114","count":7},{"id":"GO:0042448","count":6},{"id":"GO:0042574","count":6}]},{"hash":"952967210682676379","title":"mRNA splicing and translation initiation regulation","description":"This cluster is enriched for splicing regulation (positive/negative via spliceosome), alternative mRNA splicing, and mRNA modification, along with components of translation initiation (preinitiation complex formation and eIF4F assembly), indicating a cohesive role in post-transcriptional gene expression that links splicing decisions to translation initiation.","confidence":"High","size":17,"edges":127,"triangles":566,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0010610","count":13},{"id":"GO:0048025","count":13},{"id":"GO:0016556","count":12}]},{"hash":"950076403830111884","title":"Actin Cytoskeleton Remodeling","description":"The cluster\u2019s top terms are dominated by actin-related processes: actin filament polymerization, nucleation, filament network formation, barbed-end capping, parallel filament bundle assembly, and lamellipodium morphogenesis, which together point to dynamic remodeling of the actin cytoskeleton and protrusive structures. A few terms touch on broader developmental processes (somite specification, oligodendrocyte development) and mitochondrial fission regulation, but the strongest signal is actin dynamics, suggesting proteins functioning in cytoskeletal remodeling during morphogenesis and cell migration.","confidence":"High","size":17,"edges":126,"triangles":567,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0090140","count":2},{"id":"GO:0051388","count":2},{"id":"GO:0001757","count":2},{"id":"GO:0072673","count":2},{"id":"GO:0030041","count":2}]},{"hash":"277640440466782195","title":"Dopaminergic Synaptic Signaling and Cocaine Response","description":"The terms cluster around dopamine production and dopaminergic synaptic transmission, synaptic potentiation, and behavioral responses to cocaine, pointing to a dopaminergic signaling/plasticity module affected by cocaine exposure. Although an apoptotic term appears, the dominant theme is dopaminergic synaptic function and cocaine-related responses.","confidence":"High","size":17,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0042220","count":3},{"id":"GO:0034198","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0001963","count":3}]},{"hash":"186060220373645271","title":"Small GTPase Signaling in Muscle and Regeneration","description":"This cluster centers on GTPase-driven signaling: activation of GTPase activity and small GTPase-mediated signal transduction, along with integrin activation and PI3K/AKT signaling, which together link cytoskeleton dynamics, cell adhesion, and survival to muscle development and regeneration (myoblast fusion, locomotion, organ regeneration). The shared GO terms point to a cohesive theme of GTPase-regulated signaling in muscle-associated growth and repair, justifying a specific muscle-regeneration focus.","confidence":"High","size":17,"edges":4,"triangles":0,"max_degree":2,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0090630","count":5},{"id":"GO:1903833","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0045071","count":4},{"id":"GO:0033622","count":4}]},{"hash":"2194957029162549550","title":"RNA processing and translation initiation cluster","description":"Based on the GO terms, the proteins are enriched for mRNA splicing via the spliceosome, ncRNA-mediated gene silencing, mRNA export, mRNA modification, and assembly of translation initiation machinery (preinitiation complex and EIF4F). While a few terms are unrelated (e.g., DNA replication or obsolete regulations), the dominant theme centers on RNA processing and the initiation of translation, suggesting these proteins work together in RNA metabolism and early translation steps.","confidence":"High","size":17,"edges":126,"triangles":549,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":9},{"id":"GO:0031047","count":9},{"id":"GO:1901407","count":7},{"id":"GO:0006406","count":6},{"id":"GO:0006260","count":6}]},{"hash":"2150073766520054669","title":"Steroid, retinoid, sphingolipid, and pigment biosynthesis","description":"Top GO terms cluster around biosynthesis of lipid- and pigment-related molecules: estrogen biosynthesis and C21-steroid hormone metabolism point to steroid hormone production; retinal metabolic and retinoic acid biosynthetic processes cover retinoids; sphingolipid biosynthetic and 3-keto-sphinganine metabolic processes reflect sphingolipid production; melanin biosynthesis expands to pigment biosynthesis. Together these terms suggest a theme of lipid- and pigment-related biosynthetic pathways rather than a single signaling function.","confidence":"High","size":17,"edges":46,"triangles":34,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":15},{"id":"GO:0042574","count":11},{"id":"GO:0008207","count":11},{"id":"GO:0030148","count":11},{"id":"GO:0002138","count":11}]},{"hash":"2252130155016604912","title":"Neural signaling and drug-related behaviors","description":"The cluster shows brain-centric signaling and neural processing terms (ERK cascade regulation, dopaminergic synaptic transmission, brain renin-angiotensin system, prostaglandin response) alongside behavioral and sensory outcomes (visual perception/learning, pain perception) and responses to psychoactive drugs (morphine, cocaine). This points to a cohesive theme of neural signaling modulating behavior in response to drugs and sensory cues.","confidence":"High","size":17,"edges":126,"triangles":547,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0071380","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0010759","count":12}]},{"hash":"1679442913018438500","title":"Immune signaling and cell cycle progression","description":"The top GO terms combine immune signaling (response to lipopolysaccharide, GM-CSF stimulus, T cell receptor signaling) with cell cycle processes (G1/S and G2/M transitions, DNA replication/transcription), suggesting proteins involved in immune-activated proliferation or signaling that couples immune responses to cell division.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":6},{"id":"GO:0000082","count":6},{"id":"GO:0097011","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0000278","count":4}]},{"hash":"1238699922238506575","title":"Steroid and Prostaglandin Biosynthesis","description":"Top GO terms indicate prostaglandin biosynthesis, testosterone biosynthesis, and androgen metabolism, along with vitamin D response, pointing to lipid hormone/steroid biosynthesis and signaling as the core theme. The presence of unrelated terms like oxidation-reduction and microbial biosynthesis, plus the absence of edges, suggests the cluster may be functionally mixed. Overall, the strongest signal supports lipid hormone biosynthesis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0042619","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0001516","count":3},{"id":"GO:0009405","count":3}]},{"hash":"585696141304643092","title":"Actin Cytoskeleton Regulation and Morphogenesis","description":"This cluster is dominated by terms tied to actin cytoskeleton organization and Rho signaling, with additional links to various tissue morphogenesis events (heart, skeletal, mammary/salivary gland branching, olfactory bulb). The common thread appears to be cytoskeleton-driven cell shape changes during development and tissue formation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0060445","count":2}]},{"hash":"2175755955007495514","title":"Coagulation, Fibrinolysis, and Angiogenesis","description":"This cluster is driven by vascular proteolysis and remodeling processes: fibrinolysis, blood coagulation, plasminogen activation, and regulation of angiogenesis are the most frequent GO terms. While there are ancillary signals related to Rho GTPase signaling and cytoskeletal dynamics that support endothelial movement, the dominant theme ties coagulation with angiogenic processes, supporting a cohesive vascular/proteolytic function group.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":5},{"id":"GO:0045766","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0090630","count":4}]},{"hash":"2258593510086323654","title":"Multisystem Morphogenesis and Differentiation","description":"Top GO terms indicate involvement in embryonic development and tissue differentiation across multiple organs (retina/eye, forebrain, genitalia, adipocytes) along with tissue maintenance and stress responses (oxidative stress, xenobiotic response). This suggests a cluster of proteins tied to broad developmental programs across various tissues rather than a single pathway.","confidence":"Medium","size":17,"edges":46,"triangles":35,"max_degree":14,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0097192","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0032024","count":5},{"id":"GO:0060059","count":5}]},{"hash":"91265664142526506","title":"Neural development and RNA processing","description":"This cluster shows enrichment for neural development terms (brain and spinal cord development, multicellular growth) and signaling (peptidyl-tyrosine phosphorylation), along with RNA-processing activities (mRNA capping, guanine-N7 methylation). The combination suggests a group of proteins involved in neural development with regulatory roles in RNA maturation and signaling, though some terms (sterol biosynthesis, cocaine response) are less tightly tied, implying a moderate level of confidence.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0006370","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0042220","count":2}]},{"hash":"879173699703006516","title":"Ubiquitin-Proteasome Proteolysis and Circadian Regulation","description":"This cluster is dominated by ubiquitin-dependent proteolysis and ubiquitination terms (proteasomal degradation, SCF pathway, protein polyubiquitination), indicating roles in protein turnover. The circadian rhythm regulation term points to clock-linked control of degradation. Neuronal-related terms (synapse assembly, neuron apoptotic signaling) suggest this proteostasis module operates in neurons and may influence synaptic remodeling under circadian regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0042752","count":8},{"id":"GO:1903378","count":7},{"id":"GO:0000209","count":7},{"id":"GO:0031146","count":7}]},{"hash":"1833437760887682850","title":"Ribosome biogenesis and cell cycle control","description":"The cluster shows strong signals for ribosomal RNA processing and maturation (maturation of LSU-rRNA, maturation of 5.8S rRNA, ITS1 cleavage), indicating ribosome biogenesis. It also includes cell-cycle\u2013related proteolysis terms (anaphase-promoting complex\u2013dependent catabolic process, SCF-dependent ubiquitin-proteasomal degradation), suggesting coordination between ribosome assembly and cell division. This combination points to a module linking ribosome biogenesis with cell-cycle control.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031145","count":3},{"id":"GO:0001845","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0043547","count":2}]},{"hash":"29509661023605940","title":"Rho/Wnt-regulated actin remodeling and cell projection","description":"These proteins cluster around signaling that controls the cytoskeleton: Rho GTPase activity and canonical Wnt pathways regulate actin assembly, filopodium and podosome formation, and neuron projection development. The combination points to coordinated cytoskeletal remodeling driving cell movement and neurite outgrowth, with a few outlier terms (like subtelomeric heterochromatin formation) not defining the main theme. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090263","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0035023","count":5},{"id":"GO:0010976","count":5},{"id":"GO:0051017","count":5}]},{"hash":"772038425918523564","title":"Developmental transcriptional regulation","description":"The cluster centers on transcriptional control (RNA Pol II activities) and features diverse embryonic development terms (eye, heart, gonads, uterus, left/right patterning, lung morphogenesis), indicating proteins involved in regulating transcription during development across multiple tissues rather than a single pathway or tissue. ","confidence":"Medium","size":17,"edges":15,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0008584","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0060065","count":5}]},{"hash":"1347946351640474867","title":"Developmental growth and aging with ubiquitin regulation","description":"The terms cluster around development (multicellular growth, male gonad development, osteoblast differentiation), aging, transcription, and ubiquitin-related processes (polyubiquitination, ERAD), plus intraciliary transport and apoptotic signaling. This points to a broad regulatory module linking growth, tissue differentiation, and protein turnover rather than a single enzymatic function, hence a development-aging-ubiquitin theme. The lack of edges suggests a broad association rather than specific interactions.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007568","count":6},{"id":"GO:0035721","count":5},{"id":"GO:0000209","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0006351","count":5}]},{"hash":"1939551457884940979","title":"Neurodevelopmental transcriptional regulation","description":"The cluster centers on neural development and gene expression control, with GO terms for brain development, neural tube closure, and multicellular organism development, plus DNA-templated transcription and histone H3-K9 methylation (epigenetic regulation). Additional terms point to signaling (GTPase activity) and ER-stress\u2013related apoptotic signaling, suggesting a role in coordinating transcriptional programs and survival signals during neurodevelopment.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0051567","count":3},{"id":"GO:0031954","count":3}]},{"hash":"1053260272180856823","title":"Embryonic Muscle and Nervous System Development","description":"This cluster shows strong signals for skeletal muscle development and a broad set of neural development terms (globus pallidus, rhombomere, subpallium, peripheral nervous system neurons, somite specification, etc.), suggesting a developmental program spanning muscle and brain tissues in vertebrates. A few terms are more general (multicellular organism development) or outliers (pancreatic cell fate), but the core pattern supports a shared theme of embryonic differentiation across tissues.","confidence":"Medium","size":17,"edges":18,"triangles":0,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007519","count":16},{"id":"GO:0021759","count":15},{"id":"GO:0007275","count":15},{"id":"GO:0021570","count":14},{"id":"GO:2000288","count":14}]},{"hash":"1591356775854093262","title":"Embryonic neural crest and craniofacial development","description":"The GO terms cluster around developmental processes in the embryo, notably neural crest migration, brain region formation (midbrain, hypothalamus, pituitary, neural development), and craniofacial morphogenesis (roof of mouth, odontogenesis, dentin-containing tooth). There is also a broad regulatory term (negative regulation of transcription by RNA Pol II) likely reflecting gene expression control during development. Together they point to a coherent theme of early embryonic patterning across neural, craniofacial, and neuroendocrine lineages, justifying a label focused on embryonic neural crest and craniofacial development.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0090190","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0001755","count":7},{"id":"GO:0031018","count":7}]},{"hash":"1292031290029412649","title":"Neural development and axon guidance","description":"Proteins in this cluster are enriched for nervous system development, axon guidance, synapse assembly, and cell adhesion terms, suggesting roles in neuronal connectivity and neural crest-related migration. Immune terms appear less central and may reflect secondary associations. Overall, the cluster represents neural development and neuronal connectivity processes.","confidence":"High","size":17,"edges":50,"triangles":43,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":14},{"id":"GO:0007157","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0007156","count":14},{"id":"GO:0051965","count":13}]},{"hash":"930237218349192506","title":"Actin Cytoskeleton Remodeling and Synaptic Regulation","description":"GO terms converge on regulation of actin-rich structures (filopodia, podosomes), cell spreading, and small GTPase signaling, with links to dendritic spine development and GABAergic synapses. Ubiquitination and mechanotransduction also point to dynamic cytoskeletal control. This cluster likely groups proteins governing actin dynamics and synaptic adhesion/transmission in neurons.","confidence":"High","size":17,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045792","count":13},{"id":"GO:0071803","count":13},{"id":"GO:0016567","count":13},{"id":"GO:0046847","count":13},{"id":"GO:0051489","count":13}]},{"hash":"317275513069611683","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006378","count":6},{"id":"GO:0045657","count":5},{"id":"GO:0002181","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0006414","count":4}]},{"hash":"1931583623531874911","title":"Developmental Signaling Pathways","description":"The proteins cluster around multiple developmental signaling cascades (Hedgehog via Smoothened, Roundabout/ROBO signaling, ERK/JNK cascades) and development-related processes (nervous system, kidney, spermatid development). While there are also terms for ribosome biogenesis and vesicle trafficking that reflect general cellular context, the prominent theme is signaling pathways that drive development, making this a coherent developmental signaling cluster.","confidence":"Medium","size":17,"edges":9,"triangles":1,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007224","count":7},{"id":"GO:0007286","count":7},{"id":"GO:0046330","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0001822","count":7}]},{"hash":"1310742125372426659","title":"Neuronal development and axon guidance","description":"The proteins are enriched for neural-related functions: detection of acoustic stimuli, transmission of nerve impulses, dendrite self-avoidance, paranodal junction assembly, and chemorepulsion/migration of interneurons, all indicating roles in neuronal wiring and signaling. Rho signaling regulation also points to cytoskeletal changes underpinning axon/dendrite pathfinding and collateral sprouting. While a couple of terms are broader (cell adhesion, GI epithelium maintenance), the dominant theme is neural development and connectivity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":7},{"id":"GO:0030913","count":7},{"id":"GO:0019226","count":5},{"id":"GO:0070593","count":4},{"id":"GO:0035023","count":4}]},{"hash":"558808980139639767","title":"Osteoblast Differentiation and Actin Remodeling","description":"The top GO terms point to bone development and osteoblast fate commitment, alongside strong signals for lamellipodium/filopodium assembly and GTPase-regulated actin remodeling, indicating a set of proteins coordinating osteoblast differentiation with cytoskeletal dynamics and cell spreading during bone formation. This cohesive theme ties bone biology with cytoskeletal/membrane remodeling processes.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:1900026","count":5},{"id":"GO:0046847","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0030032","count":5}]},{"hash":"514660814456105158","title":"Immune signaling and B cell activation","description":"The top GO terms are dominated by immune-related processes (adaptive and innate immune responses, B cell receptor signaling, interleukin-2 production) and signaling regulation (GTPase activity, tyrosine phosphorylation), which points to a core function in immune activation and B cell\u2013mediated signaling. A few development terms appear but are less central to the cluster\u2019s primary theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0010765","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0050731","count":3},{"id":"GO:0002250","count":3}]},{"hash":"1322313194673480834","title":"Growth factor signaling and endosomal trafficking","description":"These proteins cluster around cellular responses to external cues (EGF and VEGF), GPCR/thrombin signaling, and regulation of small GTPases, alongside endosome-to-lysosome transport. This points to a cohesive theme of signal transduction coupled with intracellular trafficking, rather than a single developmental or metabolic process. Some terms appear peripheral to the main theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0045671","count":2},{"id":"GO:0071364","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1051360993015319279","title":"Rho/Ras signaling and actin remodeling","description":"The top GO terms cluster around regulation of Rho and Ras signaling, PI3K-related pathways, endocytosis, and actin cytoskeleton reorganization, with linked processes like cell spreading and adhesion. This suggests a theme of signaling pathways that orchestrate cytoskeletal dynamics and membrane trafficking, which can influence heart development. Hence a label focusing on Rho/Ras signaling coupled to actin remodeling captures the core function of this cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0046580","count":5},{"id":"GO:0010796","count":5}]},{"hash":"114686673142360908","title":"Innate antiviral response and autophagy","description":"The cluster is dominated by GO terms for innate immune response and defense against viruses, along with autophagy and ubiquitin-dependent protein degradation, suggesting a core theme of antiviral innate immunity coupled with autophagic/proteasomal processing. While there are ancillary terms related to development, microtubule localization, and calcium signaling, the strongest signals center on antiviral defense and autophagy. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":11},{"id":"GO:0051607","count":10},{"id":"GO:0051092","count":9},{"id":"GO:0007275","count":9},{"id":"GO:0035372","count":8}]},{"hash":"375863451005731796","title":"TLR\u2013NF-kappaB Cytokine Signaling","description":"The terms concentrate on Toll-like receptor signaling (including MyD88-dependent pathways), NF-kappaB activation (I-kappaB phosphorylation), and regulation of cytokine production (IL-18, IL-13, IL-17, and type II interferon), indicating a core innate immune signaling module centered on TLR-NF-kappaB\u2013driven transcriptional responses.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0034178","count":4},{"id":"GO:0032700","count":4},{"id":"GO:0032741","count":4},{"id":"GO:0032609","count":4}]},{"hash":"697584226868705927","title":"Neural development and axon guidance","description":"The top terms cluster around neuronal development: synapse assembly, interneuron migration, axonal fasciculation, and cell\u2013cell adhesion (homophilic/heterophilic), with ERK signaling involvement. While broader developmental terms like angiogenesis and skeletal system development appear, the predominant theme is neural connectivity and axon guidance during development.","confidence":"High","size":17,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0021836","count":3},{"id":"GO:0048671","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007157","count":3}]},{"hash":"2014402435559384310","title":"Neural development, synapse regulation, and myelination","description":"These proteins cluster around nervous system development themes: peripheral nervous system development, myelination, regulation of synapse assembly, and cell adhesion in neural contexts. Hedgehog signaling (Smoothened) fits developmental roles, and AV-node-related adhesion points to specialized cardiac neural conduction tissues; despite a couple outliers (symbiont entry, myoblast differentiation), the dominant signal is neural development and connectivity.","confidence":"Medium","size":17,"edges":42,"triangles":25,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":10},{"id":"GO:0051963","count":10},{"id":"GO:0086072","count":9},{"id":"GO:0043318","count":9},{"id":"GO:0007157","count":9}]},{"hash":"434715626884823551","title":"Vascular development and morphogenesis","description":"The top GO terms point strongly to angiogenesis, endothelial chemotaxis, and branching morphogenesis across tissues (e.g., salivary gland branching, skeletal development), suggesting a cluster centered on vascular development and tissue morphogenesis. Some immune and neural localization terms appear but are secondary to the vascular/morphogenesis signal. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048672","count":10},{"id":"GO:0000187","count":10},{"id":"GO:0001501","count":10},{"id":"GO:0060445","count":9},{"id":"GO:0045765","count":9}]},{"hash":"566681085908012913","title":"Ubiquitin-dependent antiviral innate immunity","description":"This cluster centers on innate antiviral responses and ubiquitin turnover, with terms for ubiquitin-dependent protein catabolic processes, protein polyubiquitination, and MyD88-dependent Toll-like receptor signaling, plus defense against viruses and IL-18 production. A couple of neuron-development terms appear less central, likely reflecting pleiotropy or signaling cross-talk rather than a core function of the cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0051607","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0000209","count":5},{"id":"GO:1905289","count":4}]},{"hash":"2285911643924577299","title":"Neurotransmission and Neuromodulation","description":"These proteins appear to function in neuronal signaling, with enrichment in excitatory postsynaptic potentials, ion transmembrane transport, and multiple neurotransmitter pathways (GABA, acetylcholine, norepinephrine). The inclusion of conditioned taste aversion and locomotory behavior suggests a role in behaviorally relevant neural circuits, supported by membrane depolarization and innervation terms.","confidence":"High","size":17,"edges":113,"triangles":397,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":16},{"id":"GO:0071805","count":16},{"id":"GO:0035725","count":16},{"id":"GO:0001661","count":15},{"id":"GO:0007626","count":15}]},{"hash":"1362715064713094411","title":"Adenylate Cyclase-Activating GPCR Signaling","description":"Dominant GO terms point to GPCR signaling that activates adenylate cyclase and engages cGMP/cAMP second messengers, with related membrane potential regulation and thermoregulation/sensory roles. This makes the GPCR-adenylyl cyclase signaling theme a concise, representative label for the cluster.","confidence":"High","size":17,"edges":5,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":7},{"id":"GO:0007190","count":7},{"id":"GO:0010579","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0019233","count":6}]},{"hash":"1973862330122395518","title":"Dopaminergic and Adrenergic Neural Signaling","description":"This cluster is dominated by GO terms for neural communication and autonomic signaling, notably dopaminergic synaptic transmission and MAPK-activating adrenergic receptor signaling. The inclusion of heart rate regulation by epinephrine/norepinephrine and prepulse inhibition reinforces a CNS/autonomic signaling theme. A few items touch on xenobiotic response, TNF production regulation, thermogenesis, and smooth muscle differentiation, but they appear ancillary to the core pattern of neurotransmission and adrenergic signaling.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":10},{"id":"GO:0071883","count":10},{"id":"GO:0001996","count":10},{"id":"GO:0048609","count":10},{"id":"GO:0051967","count":10}]},{"hash":"106474376165584719","title":"Plasma Membrane Ion Transport and Signaling","description":"The cluster's terms are dominated by processes at or near the plasma membrane, including ion transmembrane transport for potassium, calcium, and sodium, as well as membrane raft assembly and protein localization to the cell surface. Signaling-related terms such as ERBB signaling and regulation of tyrosine kinase activity further support a membrane-centric signaling role. A sarcomere organization term is present but less central, making the overall theme best described as membrane transport and signaling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0070588","count":2},{"id":"GO:0001765","count":2},{"id":"GO:0034394","count":2}]},{"hash":"860279625151765267","title":"Lymphocyte migration and actin dynamics","description":"This cluster\u2019s top GO terms center on actin cytoskeleton remodeling (lamellipodium assembly, cell spreading, actin reorganization) and cell migration, alongside immune-related processes (NKT cell differentiation, B cell maturation, interleukin production/signaling). Together they suggest proteins that govern immune cell movement and activation via cytoskeletal dynamics and cytokine pathways; hence the label focusing on lymphocyte migration and actin remodeling is appropriate.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":4},{"id":"GO:0030032","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0001865","count":4},{"id":"GO:0002344","count":4}]},{"hash":"1275381146061567046","title":"Developmental Signaling and Transcription","description":"This cluster centers on processes related to development (multicellular organism development, skin development, cell population proliferation) and on transcriptional regulation and signal transduction (DNA-templated transcription, intracellular signaling, dopamine receptor signaling, prostaglandin response). The GO terms also touch on cellular responses to external stimuli ( xenobiotic, prostaglandin), suggesting a broader developmental signaling role rather than a single, narrow function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008283","count":4},{"id":"GO:0006935","count":3},{"id":"GO:0018298","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0006351","count":3}]},{"hash":"2055159966146719027","title":"GPCR-cAMP Signaling with Immune and Vascular Responses","description":"Reason: The dominant terms point to GPCR signaling that modulates adenylate cyclase and cAMP pathways, with supporting immune-related terms (immune defense, LPS response, defense against bacteria) and vascular-related processes (blood pressure regulation). A few terms touch metabolism and bone remodeling, suggesting metabolic support for these signaling and structural processes. Overall, the cluster centers on GPCR-cAMP signaling linked to immune and vascular functions.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":5},{"id":"GO:0022900","count":3},{"id":"GO:0007195","count":3},{"id":"GO:0046849","count":3},{"id":"GO:0006955","count":3}]},{"hash":"1154569263470485323","title":"Actin Cytoskeleton Dynamics and Cell Junctions","description":"The cluster\u2019s terms converge on actin-based processes: vesicle transport along actin filaments, mitotic contractile ring actin bundle assembly, and skeletal muscle tissue development, along with tight junction assembly that relies on actin remodeling. While a few items are more peripheral (e.g., transcriptional regulation, spindle checkpoint signaling), the dominant theme is actin cytoskeleton dynamics linked to cell junctions and muscle-related processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010923","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0032516","count":1}]},{"hash":"2078832599624376780","title":"Unknown","description":"The top GO terms are highly diverse, spanning immune signaling, vascular and heart development, and general cellular processes, with no single cohesive function linking the proteins. Therefore no clear cluster theme emerges; label is Unknown. ","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":3},{"id":"GO:0086004","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0035023","count":3}]},{"hash":"1532974247340782960","title":"Metabolic Signaling and Growth Regulation","description":"These proteins cluster around signaling pathways that regulate metabolism and growth, notably Rho/GTPase signaling and insulin/IGF receptor signaling, with associations to glycogen biosynthesis, glucose import, and lipid transport. Although there are some development-related terms (heart, dendritic spine, B cell maturation), the prevailing theme is signal transduction linked to metabolic control and growth across tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0090630","count":5},{"id":"GO:0010765","count":5},{"id":"GO:0002344","count":5},{"id":"GO:0061000","count":5}]},{"hash":"1072101806417993066","title":"GTPase-Mediated Signaling and Cytoskeletal Remodeling in Immune Cells","description":"This cluster centers on small GTPase signaling (Rho/Rac/Ras) and actin cytoskeleton dynamics (filopodium/lamellipodium assembly), with several immune-related processes appearing (NK T cell differentiation, B cell affinity maturation, IL-4/IL-7 responses). The convergence of signaling and cytoskeletal terms in immune contexts suggests a cohesive role in immune cell signaling coupled to cytoskeletal remodeling.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0098761","count":4},{"id":"GO:0035020","count":4},{"id":"GO:0001865","count":4},{"id":"GO:0046847","count":4}]},{"hash":"898994184259208006","title":"Neuronal ion transport and synaptic membrane dynamics","description":"Top GO terms point to neuronal membrane processes: potassium and sodium ion transmembrane transport, synaptic vesicle uncoating, and myelin-related terms, with PI metabolism and vacuole organization supporting membrane trafficking and signaling. This suggests a cluster focused on membrane dynamics and ion flux in neural cells, rather than a single discrete pathway, giving a cautious, medium confidence in the label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0007033","count":1},{"id":"GO:0031642","count":1},{"id":"GO:0016191","count":1}]},{"hash":"366915109294280773","title":"Immune receptor signaling and actin dynamics","description":"The terms cluster around immune-related signaling (T cell receptor, ephrin receptor) and broader signaling pathways (Wnt), as well as cytoskeletal remodeling (actin branching, podosome assembly) and regulatory layers like ubiquitination and small GTPases, pointing to coordinated signal transduction and cytoskeletal changes in immune cells and related migratory processes.","confidence":"Medium","size":16,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0071803","count":4},{"id":"GO:0048013","count":4}]},{"hash":"1564429223051746723","title":"Unknown","description":"The GO terms span very different processes (development, skin development, hormone biosynthesis, prostaglandin biosynthesis, protein oligomerization, mitochondrial complex IV assembly, nitrate assimilation, and potassium transport), with no clear unifying function or pathway linking them, so a single coherent label is not identifiable.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0001516","count":2}]},{"hash":"1543555694638322835","title":"Diverse Biosynthesis and Metabolic Modification","description":"The cluster centers on assorted biosynthetic processes (lipopolysaccharide, antibiotic, cobalamin, juvenile hormone) and a set of metabolic modification activities (N-terminal peptidyl-glycine methylation, tRNA wobble uridine modification), suggesting a common theme of biosynthesis and molecular modification. Some GO terms also reflect xenobiotic or amine-related responses, indicating broader metabolic processing rather than a single, cohesive pathway. Overall, the terms point to diverse biosynthetic and post-translational/metabolic activities across different organisms.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0014075","count":3},{"id":"GO:0009103","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0017000","count":2}]},{"hash":"425789972987055626","title":"RNA processing and translation initiation","description":"The proteins cluster around translation initiation (formation of preinitiation complex, translation reinitiation, eIF4F complex assembly) and RNA metabolism steps (mRNA splicing via spliceosome, mRNA modification, polyadenylation), suggesting a cohesive group involved in mRNA maturation and the initiation of translation; a few terms are obsolete but do not obscure the overall theme.","confidence":"High","size":16,"edges":10,"triangles":1,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":7},{"id":"GO:0002188","count":6},{"id":"GO:1901407","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5}]},{"hash":"2059694060855224885","title":"Multisystem development and differentiation","description":"The top GO terms cluster around differentiation and development across several organ systems (reproductive tract, kidney, heart, cerebellum, PNS), plus related processes like cell\u2013cell junction organization and miRNA silencing regulation. This suggests the proteins participate in diverse developmental programs across tissues rather than a single cohesive pathway, justifying a general multisystem differentiation label.","confidence":"Medium","size":16,"edges":89,"triangles":264,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0061205","count":8},{"id":"GO:0045216","count":8},{"id":"GO:0072283","count":8},{"id":"GO:0055011","count":8},{"id":"GO:0046013","count":8}]},{"hash":"936839289492927902","title":"Cell adhesion and cytoskeleton remodeling","description":"The top GO terms cluster around adhesion-dependent cell spreading, lamellipodium and stress fiber assembly, wound healing, and maintenance of tissue structure, indicating a module that regulates cell adhesion and cytoskeletal dynamics to drive migration and tissue integrity. Ubiquitination and signaling terms may modulate these processes, with some development terms reflecting broader roles in organogenesis. Overall, the proteins seem to form a cohesive unit governing adhesion, polarity, and cytoskeletal remodeling during tissue remodeling.","confidence":"High","size":16,"edges":36,"triangles":22,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0044319","count":3},{"id":"GO:0043124","count":3},{"id":"GO:0030011","count":3}]},{"hash":"1936270221529452262","title":"T cell and Fc receptor signaling cluster","description":"The top GO terms center on immune receptor signaling (Fc\u03b5R and TCR), with related regulation and downstream transcriptional responses, plus broader signaling crosstalk (calcium signaling, Rho, Wnt) and defense/response terms. This points to a cohesive module of immune signal transduction and gene regulation rather than a single metabolic process, hence the label.","confidence":"Medium","size":16,"edges":7,"triangles":1,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038095","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0071560","count":4},{"id":"GO:0050860","count":4},{"id":"GO:0006968","count":4}]},{"hash":"2126551622103494838","title":"Ubiquitination-Driven Signaling Regulation","description":"Most terms point to ubiquitination and proteasome-mediated protein turnover (GO:0016567; GO:0032436), with several entries also referencing modulation of signaling pathways (NF-kappaB, Wnt, EGFR) and related cellular responses. A few terms touch on neuronal development or immune differentiation, but these appear secondary. Therefore the cluster seems centered on proteins involved in tagging/degrading substrates and modulating signaling, i.e., ubiquitination-driven signaling regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0021942","count":3},{"id":"GO:0051092","count":2},{"id":"GO:0045627","count":2},{"id":"GO:0090263","count":2}]},{"hash":"613067187847527200","title":"RTK Signaling and Developmental Cues","description":"Top GO terms cluster around receptor tyrosine kinase (RTK) signaling (peptidyl-tyrosine autophosphorylation; TRK and PDGF receptor pathways) and related endocytic regulation (caveolin-mediated endocytosis). Additional terms point to developmental signaling inputs (Wnt, retinoic acid) and mammary gland branching, suggesting a role in RTK-driven signaling and developmental cues. A few terms (e.g., subtelomeric heterochromatin formation) are less connected, but overall the theme is signaling and development.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060444","count":4},{"id":"GO:0048011","count":3},{"id":"GO:0010641","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0098761","count":3}]},{"hash":"645149613434002169","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":48,"triangles":69,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0075522","count":3},{"id":"GO:0001825","count":3}]},{"hash":"703851514663540057","title":"Nervous system development and glutamatergic synaptic function","description":"The dominant GO terms point to nervous system development (GO:0007399) and glutamatergic synaptic transmission (GO:0035249), with supporting signals for auditory sensing and myelination, indicating a coherent theme of neuronal development and excitatory synaptic function; RNA processing and transcription regulation terms suggest neuron-specific gene expression control.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0035249","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0048255","count":2}]},{"hash":"1972982608676785973","title":"mRNA Splicing and Translation Initiation","description":"The proteins cluster around RNA processing and translation control: spliceosome-mediated splicing (splice site recognition, splicing via spliceosome, mRNA modification), regulation of mRNA stability in response to stress, regulatory ncRNA-mediated gene silencing, and components involved in translation initiation (preinitiation complex formation, eIF4F complex assembly) and translation reinitiation. This points to a coherent theme of post-transcriptional gene expression regulation through splicing and initiation of translation.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0048026","count":7},{"id":"GO:0006376","count":6},{"id":"GO:0010610","count":6}]},{"hash":"857868139970740548","title":"Steroid, retinoid, and pigment biosynthesis","description":"This cluster centers on biosynthesis and metabolism of steroids, retinoids, sphingolipids, and pigmented compounds (retinal, retinoic acid, estrogens, melanin). The recurring theme is lipid-derived metabolite production and pigment biosynthesis, despite a few outliers like antibiotic biosynthesis.","confidence":"Medium","size":16,"edges":91,"triangles":248,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0042574","count":8},{"id":"GO:0008207","count":8},{"id":"GO:0030148","count":8},{"id":"GO:0002138","count":8}]},{"hash":"1029654804921691445","title":"Steroid and lipid metabolite biosynthesis","description":"Based on the top GO terms, the proteins are enriched for biosynthetic processes of lipid- and hormone-related metabolites, including retinoids (retinal and retinoic acid), steroids (estrogen, C21-steroid hormones), sphingolipids, and even melanin. Although a few terms are unrelated, the common theme is production of lipid- and pigment-related metabolites, suggesting this cluster centers on steroid/retinoid/lipid biosynthesis pathways.","confidence":"High","size":16,"edges":93,"triangles":271,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":16},{"id":"GO:0042574","count":14},{"id":"GO:0008207","count":14},{"id":"GO:0030148","count":14},{"id":"GO:0002138","count":14}]},{"hash":"27698988599620346","title":"Epithelial morphogenesis and differentiation","description":"These terms converge on epithelial development and remodeling: keratinocyte differentiation, collagen ECM organization, Notch signaling, and palatal morphogenesis with epithelial apoptosis, plus associated angiogenesis and inflammatory responses.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0030199","count":4},{"id":"GO:0010042","count":4},{"id":"GO:0007220","count":4},{"id":"GO:0034612","count":4}]},{"hash":"1193024828274402698","title":"Coagulation, fibrinolysis, and endothelial barrier regulation","description":"The top GO terms coalesce around vascular coagulation (positive regulation of blood coagulation, Factor XII activation), fibrinolysis and plasminogen activation, and endothelial barrier maintenance, with supporting signals from smooth muscle migration and lectin pathway complement activation. There are also immune response cues (response to lipopolysaccharide), suggesting a vascular inflammatory context. The transcription regulator term may be incidental to this core vascular/coagulation theme, but the dominant signal points to coagulation and endothelial biology.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1903142","count":6},{"id":"GO:0010756","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0014909","count":5},{"id":"GO:0032496","count":5}]},{"hash":"1768848552074944637","title":"Synaptic organization and Rho signaling","description":"These proteins cluster around synaptic localization and arrangement (receptor clustering, protein localization to synapse, dendritic spine morphogenesis) and Rho-mediated cytoskeletal signaling (Rho protein signal transduction and its regulation). Despite a couple of unrelated/obsolete terms, the dominant theme is synaptic organization linked to Rho-driven remodeling.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0070433","count":11},{"id":"GO:0043113","count":11},{"id":"GO:0060997","count":11},{"id":"GO:0007266","count":11},{"id":"GO:0008285","count":11}]},{"hash":"670859823522298982","title":"Mitochondrial phospholipid remodeling","description":"The top terms are dominated by lipid remodeling and biosynthesis, including phosphatidylcholine acyl-chain remodeling, cardiolipin remodeling, ether lipid biosynthesis, and CDP-diacylglycerol biosynthesis, all of which are central to mitochondrial membrane composition and function (mitochondrial ATP synthesis). A few unrelated terms appear, but the core signal points to mitochondrial phospholipid metabolism. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036151","count":4},{"id":"GO:2001246","count":3},{"id":"GO:0008611","count":3},{"id":"GO:0035965","count":3},{"id":"GO:0016024","count":3}]},{"hash":"1600583791986211750","title":"Neural and Cardiac Development","description":"The top GO terms point to neural lineage specification (subpallium neuron fate commitment, auditory receptor cell fate determination, oligodendrocyte development) and timing of neural differentiation, alongside cardiac morphogenesis (endocardial cushion-to-mesenchymal transition in heart valve formation, sinus venosus morphogenesis). This pattern suggests a cluster of proteins involved in developmental differentiation programs spanning neural and cardiac tissues, with transcription by RNA polymerase II indicating broad regulatory activity. A few terms (humoral immune response) are peripheral to the main theme, but overall the cluster centers on embryonic development in neural and cardiac contexts.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0060163","count":15},{"id":"GO:2000981","count":15},{"id":"GO:2000802","count":15},{"id":"GO:0014003","count":15}]},{"hash":"1937321027556730464","title":"Embryonic tissue differentiation","description":"Top GO terms point to embryonic development and differentiation across several tissues: somitogenesis, floor plate formation, skeletal muscle and myoblast differentiation, retinal amacrine cells, melanocytes, and neural fate commitment. The shared theme is lineage specification during early development rather than a single pathway, so the label Embryonic tissue differentiation reflects the cluster's overall function.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0001756","count":8},{"id":"GO:0033504","count":8},{"id":"GO:0060426","count":8},{"id":"GO:0035881","count":8}]},{"hash":"1127033926472704157","title":"Mitotic Cell Cycle and Division Machinery","description":"Based on the GO terms, the strongest signals are mitotic cell cycle, mitotic spindle assembly, and cell division, indicating a cluster centered on mitosis and chromosome segregation. Other terms like lipid homeostasis or transport appear ancillary, and some entries are obsolete, but they do not override the clear mitosis/division theme. Therefore this label captures the core function of the cluster.","confidence":"High","size":16,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":7},{"id":"GO:0010628","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0000060","count":6},{"id":"GO:0071806","count":6}]},{"hash":"1530622845619115524","title":"Mitotic Nuclear Envelope Reassembly and Transport Regulation","description":"This cluster is dominated by mitosis-related terms (mitotic cell cycle, mitotic nuclear membrane reassembly) and nuclear transport (nuclear pore complex assembly, mRNA transport), plus GTPase and phosphorylation regulation and TORC1 signaling, suggesting a cohesive module coordinating cell division with nuclear envelope reformation and nuclear transport.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0051292","count":4},{"id":"GO:0051028","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0038202","count":3}]},{"hash":"1581846561921366972","title":"Cross-tissue morphogenesis and cell adhesion","description":"Genes in this cluster co-occur with developmental and morphogenetic processes across multiple organs (brain, heart, kidney) and with components of cell junctions and the cytoskeleton (desmosome assembly, intermediate filament bundle assembly). This combination suggests a shared role in tissue formation and stable cell\u2013cell interactions during organogenesis, spanning medulla oblongata development, midbrain dopaminergic neuron differentiation, metanephros morphogenesis, renal vesicle formation, and cardiac conduction system adhesion.","confidence":"High","size":16,"edges":81,"triangles":213,"max_degree":15,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":11},{"id":"GO:0021550","count":10},{"id":"GO:0003338","count":10},{"id":"GO:0086073","count":10},{"id":"GO:0071255","count":10}]},{"hash":"630754841649928907","title":"Ubiquitin-Proteasome Regulation of Circadian and Cell Cycle","description":"The dominant terms show ubiquitin-dependent protein catabolic processes, protein polyubiquitination, and SCF-proteasome\u2013mediated degradation, with additional links to circadian rhythm and G1-phase cell cycle control, suggesting a cluster focused on ubiquitin-mediated turnover coordinating cell cycle and circadian regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0042752","count":6},{"id":"GO:1902916","count":4},{"id":"GO:0000209","count":4},{"id":"GO:0031146","count":4}]},{"hash":"2017089690953159392","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around embryonic and placental development and tissue morphogenesis, including placenta differentiation, left/right patterning, cartilage morphogenesis, pancreatic cell development, and EMT-related processes, plus broader endocrine development and signaling regulation. This suggests a cohesive theme of developmental differentiation and morphogenesis across tissues, rather than a single specific pathway, justifying the label. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0003198","count":3}]},{"hash":"1545710571202536870","title":"Eye and Brain Development","description":"This cluster is dominated by GO terms for ocular morphogenesis and neural development: retina development, camera-type eye development, embryonic eye morphogenesis, and cerebellum development, suggesting the proteins co-localize to pathways guiding eye and brain structure formation. Some outlier terms (osteoblast development, xenobiotic response) may reflect broader roles or annotation noise, but the core signal supports an eye-and-brain development theme.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0002087","count":7},{"id":"GO:0060041","count":6},{"id":"GO:0002076","count":6},{"id":"GO:0060441","count":5}]},{"hash":"1359234865532323677","title":"Embryonic and organ development","description":"This cluster centers on developmental processes across multiple tissues and organs, as shown by GO terms for brain/forebrain and retina development, neural crest formation, thyroid and gonad development, gut morphogenesis, and ureteric bud branching. The diversity of organ-specific development terms suggests a broad role in organismal development rather than a single pathway. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0030878","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0030900","count":4}]},{"hash":"232082004825594171","title":"Calcium-triggered secretory exocytosis in neural/endocrine cells","description":"The GO terms show insulin secretion in response to glucose, positive regulation of dense core granule exocytosis, and cellular calcium signaling, pointing to a calcium-dependent secretory/exocytic process typical of neural and endocrine cells. The presence of a term related to myelination in the peripheral nervous system supports a neural context. Some other terms (tRNA processing, Pol I transcription, Rho signaling) are broader cellular processes that may appear in many clusters, making the core theme less uniform, but the strongest signal centers on calcium-driven secretion and exocytosis in neural/endocrine contexts.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035773","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0038028","count":1},{"id":"GO:0035023","count":1}]},{"hash":"551198366219967236","title":"Spermatogenesis and flagellar function","description":"GO terms show a coherent focus on testis biology and sperm development, including flagellated sperm motility, acrosome assembly, and Leydig cell\u2013related testosterone signaling with LH involvement; microtubule organization at centrosomes supports flagellum formation, supporting a sperm development theme. High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030317","count":2},{"id":"GO:0034454","count":2},{"id":"GO:0031122","count":2},{"id":"GO:0045742","count":2},{"id":"GO:0045022","count":2}]},{"hash":"1756917969929314325","title":"Neural development and cytoskeletal movement","description":"The terms show a clear emphasis on neural development (nervous system development, brain development, eye development) and associated behaviors (adult locomotory behavior), with supporting terms tied to cytoskeletal dynamics (microtubule-based movement, GTPase activity regulation). Although other developmental themes (bone, VEGF signaling, apoptosis) appear, the strongest, coherent theme is neural development coupled with cytoskeletal control. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0060348","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1312605538094458008","title":"Neural signaling and calcium-related development","description":"The top GO terms emphasize neural development and signaling, including Wnt signaling, corticospinal tract morphogenesis, and regulation of synaptic plasticity via receptor localization, plus calcium ion detection and vitamin D\u2013responsive signaling, suggesting a neural development/communication theme with calcium involvement. While a few terms touch on other processes (e.g., telomere maintenance, SA node activity), the prevailing pattern points to neural signaling and development with a calcium connection.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0033280","count":2},{"id":"GO:0007182","count":2},{"id":"GO:0021957","count":2},{"id":"GO:0098907","count":2}]},{"hash":"1768442904446945608","title":"Steroid and lipid hormone biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for prostaglandin, ecdysone, progesterone, bile acids, and retinoic acid, all of which are lipid- or steroid-derived signaling molecules. This points to a cluster of proteins involved in the production and turnover of hormonal lipids and related mediators, with some additional diverse biosynthetic activities (e.g., macrolide biosynthesis) and associated stress-response terms that may reflect broader metabolic capabilities. Overall, the common theme is biosynthesis of lipid- and steroid-based signaling molecules. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":12},{"id":"GO:0033068","count":11},{"id":"GO:0006697","count":11},{"id":"GO:0042448","count":11},{"id":"GO:0010193","count":11}]},{"hash":"339051933306363603","title":"Cardiac muscle development and calcium signaling","description":"This cluster is dominated by terms related to heart muscle development, cardiac conduction, and calcium handling (SR calcium release, Purkinje-to-ventricular signaling, atrial action potential regulation, outflow tract morphogenesis), suggesting a cohesive theme around cardiac muscle function and development. A few terms reference nervous system or bone development, which are less central to the main theme, but the strongest signal is cardiac muscle biology.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0007275","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0002024","count":3},{"id":"GO:0014808","count":3}]},{"hash":"1608993953458994765","title":"GPCR-cAMP/cGMP signaling and sensory perception","description":"The top terms are dominated by GPCR signaling, adenylate cyclase activation, and second-messenger pathways (cAMP/cGMP), along with sensory modalities (vision, pain) and neutrophil chemotaxis, indicating a cluster centered on GPCR-mediated signaling and sensory processes; a few peripheral terms (electron transport, thermogenesis) may reflect broader physiological regulation.","confidence":"High","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0007190","count":8},{"id":"GO:0010579","count":8},{"id":"GO:0002024","count":6}]},{"hash":"1913340452413883680","title":"Rho-regulated cell migration and adhesion","description":"The top GO terms cluster around Rho protein signal transduction regulation, cell migration, and adhesion-related processes (e.g., positive regulation of substrate adhesion-dependent cell spreading, fibroblast migration). Endosome organization may reflect trafficking roles that support signaling and migration. Together these indicate a cohesive theme of cytoskeletal dynamics and motility governed by Rho signaling, justifying this name.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:2001275","count":3},{"id":"GO:0007032","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0016477","count":3}]},{"hash":"534033140579509310","title":"Unknown","description":"The top GO terms span apoptosis regulation in heart tissue, NF-kappaB signaling, protein kinase regulation, ncRNA-mediated silencing, LPS response, osmosensory/MAPK signaling, melanin biosynthesis, Rap signaling, adrenergic GPCR signaling, and glomerulus development. This broad mix shows no single cohesive function uniting the proteins, so a single interpretable theme is not evident.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010667","count":2},{"id":"GO:0042346","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0071222","count":2}]},{"hash":"1490911920672880361","title":"Heart development and blood pressure regulation","description":"The cluster centers on cardiovascular development (heart formation) and regulation of systemic arterial blood pressure, suggesting a cardiovascular theme. Additional terms reference stress and immune responses (interferon-alpha, heat, hydrogen peroxide), which may be ancillary to the core cardiovascular signals.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003085","count":2},{"id":"GO:0060914","count":2},{"id":"GO:0032926","count":2},{"id":"GO:0070389","count":1},{"id":"GO:0035457","count":1}]},{"hash":"421723108466271005","title":"Mitochondrial energy and lipid metabolism","description":"The GO terms cluster around mitochondria-related energy and lipid pathways: triglyceride biosynthesis, cholesterol metabolism, regulation of cellular respiration, mitophagy, and ATP synthase complex assembly, pointing to a cohesive theme of mitochondrial energy production and lipid handling. A few terms (enkephalin processing, embryo axis specification) seem less connected and may reflect annotation noise. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":2},{"id":"GO:0000422","count":1},{"id":"GO:0010259","count":1},{"id":"GO:0043457","count":1},{"id":"GO:0033615","count":1}]},{"hash":"1186584041750763905","title":"Multi-tissue differentiation","description":"The top GO terms suggest involvement in development and differentiation across multiple tissues and lineages, including immune cells (dendritic and memory T cells), muscle, kidney tubules, pancreas, heart (endocardial EMT), and trophoblasts. This points to a broad theme of differentiation programs rather than a single, cohesive pathway, making a generic \u201cmulti-tissue differentiation\u201d label appropriate. The presence of a ubiquitination term may relate to regulatory processes underlying differentiation, but it does not refute the overall theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0042092","count":2},{"id":"GO:0045496","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0043380","count":2}]},{"hash":"978879810547207347","title":"NF-kB Signaling and Ubiquitin-Proteasome Regulation","description":"This cluster is dominated by ubiquitination and proteasomal degradation terms (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination) and NF-\u03baB signaling, including positive regulation of canonical NF-kappaB and NOD2 signaling pathways that feed into NF-\u03baB activation. Development-related terms (multicellular organism development, skin development) suggest roles in tissue formation, while mitotic spindle assembly and SA node regulation appear less central but may reflect broader cellular contexts. Overall, the proteins seem connected through regulated protein turnover influencing inflammatory signaling and development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090307","count":8},{"id":"GO:0070431","count":8},{"id":"GO:0043123","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0016567","count":8}]},{"hash":"2127142243952826244","title":"Auditory neuron development and synapse formation","description":"The cluster is enriched for auditory-related terms (auditory receptor cell development, detection of mechanical stimulus involved in sensory perception of sound) plus synapse organization/assembly and axonal fasciculation, indicating roles in auditory neuron morphogenesis and synaptic connectivity; accompanying Rho signaling and ERK cascade regulation support neurite growth and synapse formation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0048671","count":5},{"id":"GO:0050808","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007413","count":5}]},{"hash":"772002352080173713","title":"Neural development and transcription regulation","description":"The top GO terms point to nervous system development (spinal cord, brain) and organismal growth, with additional signals of transcriptional regulation, microtubule-based movement, and epigenetic/post-translational control, suggesting a cluster tied to neural development and gene-expression regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":3},{"id":"GO:0000209","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0035264","count":2}]},{"hash":"521082322680073389","title":"Pollen exine formation and anther dehiscence","description":"The top GO terms center on plant reproductive development, notably pollen exine formation and anther dehiscence, with supporting processes such as protein N-linked glycosylation and nucleotide-sugar catabolism (UDP/GDP/CDP/ADP). This points to a cohesive theme of pollen wall biosynthesis and pollen release during flowering.","confidence":"High","size":15,"edges":92,"triangles":318,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0009901","count":5},{"id":"GO:0071405","count":5},{"id":"GO:0046706","count":5},{"id":"GO:0006487","count":5},{"id":"GO:0006256","count":5}]},{"hash":"2088700948200847342","title":"Innate immune activation and inflammasome signaling","description":"The terms are dominated by innate immunity and inflammation (inflammatory response, NLRP3 inflammasome assembly, interleukin-1 production, innate immune response, apoptotic processes, MHC class I biosynthetic regulation, ubiquitination). A couple of neural-development terms appear peripherally, but the core signature points to inflammasome-driven inflammatory signaling and immune activation, making this a coherent cluster of immune-related function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":8},{"id":"GO:0090307","count":7},{"id":"GO:0022028","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0044546","count":6}]},{"hash":"2291174073641505610","title":"Neural plasticity and immune signaling","description":"The top terms center on memory and neuronal synaptic plasticity, plus astrocyte differentiation and immune-related processes such as NF-kappaB signaling and complement activation, suggesting a neural-immune differentiation theme. Some terms (EMT, terminal web) are broader cytoskeletal/differentiation contexts, but the core pattern points to neural plasticity with immune modulation.","confidence":"Medium","size":15,"edges":14,"triangles":2,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007613","count":6},{"id":"GO:0048708","count":5},{"id":"GO:0001837","count":5},{"id":"GO:0045917","count":5},{"id":"GO:0043123","count":5}]},{"hash":"1570527746249296439","title":"Bacterial fatty acid and lipoteichoic acid biosynthesis","description":"The top GO terms cluster around fatty acid biosynthesis and lipid metabolism (long- and medium-chain fatty acids, fatty-acyl-CoA metabolism) plus lipoteichoic acid biosynthesis, which is characteristic of Gram-positive bacterial cell wall lipid assembly. Although a plant-related term (seed coat development) and obsolete entries appear, the dominant signals point to a cohesive bacterial lipid biosynthesis theme. ","confidence":"High","size":15,"edges":102,"triangles":417,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006633","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0019654","count":3},{"id":"GO:0010214","count":3},{"id":"GO:1902987","count":3}]},{"hash":"1639350043606018894","title":"Synaptic signaling and neuronal development","description":"Most enriched terms point to neuronal communication and plasticity: excitatory postsynaptic potential, neurotransmitter secretion, and long-term potentiation. This suggests a cluster of proteins involved in synaptic signaling and neural circuit maturation. While terms like heart development and ossification appear, the core theme aligns with neuronal differentiation and development, supported by signaling-related terms such as positive regulation of GTPase activity and peptidyl-threonine phosphorylation. Overall, the cluster best reflects neural synaptic function with development.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0007269","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0043931","count":3}]},{"hash":"2261643301673644408","title":"Nuclear Transport and Kinetochore Regulation","description":"Go terms indicate a module of nuclear import/export (NLS-bearing proteins, Ran signaling, ribosomal subunit export) together with mitotic/kinetochore activities (centrosome duplication regulation, kinetochore localization, metaphase chromosome alignment). This points to a cohesive role in coordinating nuclear trafficking with chromosome alignment and spindle/kinetochore function during mitosis.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034501","count":3},{"id":"GO:0006609","count":3},{"id":"GO:0000056","count":3},{"id":"GO:0031291","count":3},{"id":"GO:0042176","count":3}]},{"hash":"1166072808395279710","title":"Neuronal signaling and vesicle exocytosis regulation","description":"Top terms indicate nervous system development, dopamine response, and calcium-dependent exocytosis, with signaling cascades including ERK, JNK, and Wnt pathways. This points to proteins that coordinate dopamine-evoked neuronal signaling and regulated neurotransmitter release, potentially linking development cues to synaptic vesicle exocytosis.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":15},{"id":"GO:0031647","count":15},{"id":"GO:0070374","count":15},{"id":"GO:1903351","count":15},{"id":"GO:0046330","count":15}]},{"hash":"2280480086253501825","title":"Lung morphogenesis and basement membrane remodeling","description":"This cluster is dominated by GO terms for lung morphogenesis and epithelial tube branching, with a coherent emphasis on basement membrane disassembly and proteolysis indicating extracellular matrix remodeling. Additional terms point to immune and inflammatory processes (T cell cytotoxicity, bradykinin catabolic process) and other tissue remodeling contexts (decidualization, bone resorption), suggesting a set of proteins involved in dynamic tissue structuring with ECM turnover across contexts, most strongly tied to lung development.","confidence":"Medium","size":15,"edges":35,"triangles":22,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":5},{"id":"GO:0046697","count":5},{"id":"GO:0060448","count":5},{"id":"GO:0001913","count":5},{"id":"GO:0050790","count":5}]},{"hash":"1360927127005389032","title":"Neural Development and Axon Regeneration Regulation","description":"The top GO terms point to brain development and neuronal growth processes (e.g., cerebellar cortex formation, regulation of axon regeneration) as the core theme, with additional signals around transcription and signaling pathways. While broader terms exist (potassium transport, transcription), the neural development/regeneration signals are the strongest coherence across the cluster.","confidence":"Medium","size":15,"edges":7,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006813","count":12},{"id":"GO:0006351","count":12},{"id":"GO:0048679","count":11},{"id":"GO:2001275","count":11},{"id":"GO:0033598","count":11}]},{"hash":"1086876122100712590","title":"SMAD-driven embryogenesis and organogenesis","description":"This cluster centers on embryonic development and organ formation, with vasculogenesis, neural tube closure, and myocardial precursor differentiation pointing to morphogenesis, and SMAD signaling indicating TGF-beta/BMP pathway involvement. Additional terms like placental development, sex determination, and regulation of apoptosis/deubiquitination support a cohesive developmental theme. ","confidence":"High","size":15,"edges":21,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001570","count":3},{"id":"GO:0060395","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0003257","count":2},{"id":"GO:0042981","count":1}]},{"hash":"762756615494337663","title":"Oxidative stress response and redox homeostasis","description":"The cluster is dominated by GO terms related to cellular redox homeostasis, oxidant detoxification, and response to oxidative stress, indicating a cohesive theme of managing oxidative stress. A related term on protein folding in the ER suggests a link to ER stress, which commonly accompanies oxidative stress. Some remaining terms appear unrelated (viral process, obsolete terms), but the core signals point to redox balance and oxidative defense as the cluster\u2019s common function.","confidence":"High","size":15,"edges":15,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1903206","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0006662","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0034599","count":1}]},{"hash":"773445380177552795","title":"Unknown","description":"The top GO terms span diverse processes, including mitotic cell cycle and cytokinesis regulation, NF-kappaB signaling, cellular response to xenobiotic stimulus, and multiple biosynthetic pathways (molybdopterin, biotin, menaquinone) plus tRNA methylation and a developmental term. This broad mix lacks a single coherent function to unify the cluster, so a precise label is not supported.","confidence":"","size":15,"edges":96,"triangles":346,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032465","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006777","count":3}]},{"hash":"705713762971975408","title":"Unknown","description":"The GO terms cover a mix of metabolic biosynthesis and catabolic processes (histidine, alanine, kynurenine, fatty acids, menaquinone, insulin), plus signaling terms (Notch, cAMP response) and an obsolete term, with no single unifying function apparent across the cluster. This makes a cohesive, representative label difficult to assign.","confidence":"","size":15,"edges":17,"triangles":9,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000105","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0051591","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0042853","count":3}]},{"hash":"559680083536660417","title":"Fungal sterol and ubiquinone biosynthesis","description":"The cluster is defined by ergosterol biosynthesis and ubiquinone biosynthetic processes, signaling lipid metabolism typical of fungi. The presence of stress-related terms (response to xenobiotic/toxic substance, hydrogen peroxide biosynthesis) supports a context of oxidative stress handling alongside lipid biosynthesis. Other terms (nitrate assimilation, phenylacetate catabolic process, translation, development) are ancillary and do not override the sterol/quinone biosynthesis signal.","confidence":"Medium","size":15,"edges":39,"triangles":21,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006814","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0042128","count":2},{"id":"GO:0050665","count":2},{"id":"GO:0042493","count":2}]},{"hash":"920047190756357847","title":"Mitochondrial energetics and morphogenesis","description":"This cluster centers on mitochondrial energy and calcium handling (ATP synthesis driven by the proton motive force; mitochondrial calcium import and regulation) and includes developmental processes such as angiogenesis and morphogenesis of neural/pituitary lineages (substantia nigra development, adenohypophysis morphogenesis, vascular branching). The shared theme appears to be mitochondrial function linked to energy/calcium signaling in developmental contexts, making this a coherent label, albeit with some diverse developmental terms. ","confidence":"Medium","size":15,"edges":96,"triangles":348,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0015986","count":3},{"id":"GO:0036444","count":2},{"id":"GO:0051561","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0021762","count":2}]},{"hash":"1272087558470218509","title":"Ribosome biogenesis and cell division","description":"This cluster is dominated by ribosome-related processes: cytoplasmic translation, ribosome biogenesis, ribosomal subunit biogenesis/export, and tRNA modification, indicating a core role in protein synthesis. It also includes cell cycle and cell division terms, suggesting coordination between ribosome production and cell proliferation. A few terms about septum assembly and cellular fusion appear but seem secondary to the translation/biogenesis theme.","confidence":"Medium","size":15,"edges":15,"triangles":13,"max_degree":6,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":5},{"id":"GO:0090529","count":4},{"id":"GO:0000747","count":4},{"id":"GO:0007049","count":4},{"id":"GO:1901001","count":4}]},{"hash":"647536841893976633","title":"Flavonoid Biosynthesis","description":"This cluster is dominated by GO terms for biosynthesis of flavonoid-related compounds: anthocyanin-containing compounds and flavonol glycosides (quercetin and kaempferol). These points strongly suggest a flavonoid/phenylpropanoid biosynthesis theme. The other terms (antibiotic metabolism, estrogen catabolic process, transcription regulation, and axon paranode localization) appear as downstream or unrelated associations, indicating some noise but not overriding the flavonoid signal.","confidence":"Medium","size":15,"edges":21,"triangles":14,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0017000","count":4},{"id":"GO:0009718","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0002175","count":3}]},{"hash":"56542071939095936","title":"Chromatin organization and epigenetic regulation","description":"Top terms center on nucleosome assembly and histone modification, with hints at DNA methylation control. Developmental processes like organ morphogenesis and spermatid nucleus differentiation suggest this chromatin-related role is relevant during development. The overall pattern points to chromatin organization and epigenetic regulation as the cluster's main theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":3},{"id":"GO:0000462","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0060669","count":2},{"id":"GO:0007098","count":2}]},{"hash":"962515429311977566","title":"Muscle Contraction Regulation (all muscle types)","description":"The terms cluster around regulation and execution of muscle contraction across skeletal, cardiac, and smooth muscle, including contraction, filament sliding, and regulation of ATP-dependent activity, indicating a unified theme of muscle contraction control. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031444","count":2},{"id":"GO:0032780","count":2},{"id":"GO:0006942","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0045932","count":2}]},{"hash":"1533272344014589025","title":"Inner ear sensory development and signaling","description":"The cluster is enriched for terms tied to the inner ear: auditory receptor cell development, detection of mechanical stimulus involved in sound perception, and vestibular reflex, which together indicate sensory function in the ear. While other terms reflect general cellular processes (phosphorylation, NAD(P) metabolism, polyphosphate metabolism, calcium transport regulation), the ear-specific terms dominate, supporting a focus on inner ear sensory development and signaling.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030511","count":2},{"id":"GO:0016310","count":1},{"id":"GO:0006797","count":1},{"id":"GO:0006741","count":1},{"id":"GO:0019674","count":1}]},{"hash":"2212523057212694634","title":"Bacterial secondary metabolism and aromatic compound catabolism","description":"Top GO terms cluster around biosynthesis of secondary metabolites (antibiotic, biotin, menaquinone; methionine noted as obsolete) and catabolic pathways for aromatic or xenobiotic compounds (beta-ketoadipate pathway, 1,2-dichloroethane catabolic process, alkaloid metabolism), as well as redox-related detoxification. This suggests a cohesive theme of microbial metabolism involving production of secondary metabolites and breakdown of aromatic/xenobiotic compounds. A plant-specific term present may be annotation noise rather than representative of the cluster\u2019s core function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":6},{"id":"GO:0009102","count":6},{"id":"GO:0042952","count":6},{"id":"GO:0009234","count":5},{"id":"GO:0009086","count":5}]},{"hash":"13710234546980591","title":"Developmental transcriptional regulators","description":"Top GO terms emphasize DNA-templated transcription and regulation of transcription initiation, paired with diverse developmental processes (neural, embryonic, glandular, cartilage, adipose, and gonad development), indicating these proteins commonly function as transcriptional regulators orchestrating developmental programs.","confidence":"Medium","size":15,"edges":30,"triangles":16,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0045872","count":7},{"id":"GO:0070384","count":5},{"id":"GO:0017055","count":5},{"id":"GO:0060534","count":5}]},{"hash":"59391403132765150","title":"Unknown","description":"The GO terms cover a wide range of biosynthetic and metabolic processes (macrolide, ecdysone, progesterone, bile acids, retinoic acid), along with phosphorylation and various stress responses. There is no single dominant function or theme that ties all terms together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":21,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":4},{"id":"GO:0033068","count":3},{"id":"GO:0006697","count":3},{"id":"GO:0042448","count":3},{"id":"GO:0010193","count":3}]},{"hash":"300970619803552352","title":"Adaptive and Innate Immune Response","description":"This cluster is enriched for immune-related GO terms spanning both adaptive (adaptive immune response, regulation of T cell proliferation, T cell degranulation) and innate immunity (innate immune response, complement activation, NK cell cytotoxicity, tumor cell detection). The combination suggests a cohesive immune surveillance and regulation module that coordinates responses to pathogens and tumor cells, rather than a single metabolic or signaling pathway. The presence of virion attachment and cell communication terms likely reflects interactions with immune recognition processes. Overall, the proteins appear to function together in immune defense and modulation.","confidence":"High","size":15,"edges":4,"triangles":1,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046007","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0002250","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0002860","count":5}]},{"hash":"505282473123650438","title":"Neurodevelopment and Axon Guidance","description":"Top terms center on nervous system development, neurogenesis, myelination, and axon guidance/migration (Roundabout and Smoothened signaling, paranode localization). This points to a neuronal development/axon guidance theme, with a few terms like kidney development and myoblast fusion being less central background functions.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0007224","count":8},{"id":"GO:0035385","count":8},{"id":"GO:0007520","count":8},{"id":"GO:0051965","count":8}]},{"hash":"1376724629846713930","title":"Actin remodeling during immune phagocytosis","description":"The cluster is dominated by terms tied to endocytosis/phagocytosis and actin cytoskeleton dynamics (filopodium formation, actin crosslinking/bundle assembly, cell spreading), plus adaptive immune response. This points to immune cells reorganizing their actin network to engulf material and engage in immune signaling, making a cohesive theme around actin-driven phagocytic activity in immunity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900026","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0006897","count":4},{"id":"GO:0051764","count":4},{"id":"GO:0051017","count":4}]},{"hash":"694552540077467433","title":"Vesicle trafficking and protein secretion","description":"The top GO terms cluster around ER-to-Golgi transport, COPII-coated vesicle budding, protein localization to the plasma membrane, exocytosis, endosome transport, and vacuole targeting, all pointing to the secretory and vesicular trafficking pathway. A few terms related to growth and prospore assembly are present but seem ancillary to the core trafficking theme.","confidence":"High","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903078","count":9},{"id":"GO:0006888","count":9},{"id":"GO:0045956","count":8},{"id":"GO:0031321","count":8},{"id":"GO:0006623","count":7}]},{"hash":"220989057651094789","title":"Rho GTPase\u2013driven cytoskeleton and junction dynamics","description":"The top terms cluster around small GTPase signaling, especially Rho regulation, lamellipodium (actin) assembly, and processes tied to cell\u2013cell junctions and barrier establishment (tight junctions, endothelial barrier). This points to a cohesive module of cytoskeletal remodeling governed by Rho-family GTPases that also influences cell adhesion, with a few development-related terms as broader context. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0048863","count":2}]},{"hash":"1679368251530831394","title":"Unknown","description":"This cluster shows a highly diverse mix of GO terms\u2014from transcription and RNA processing to vesicle transport, apoptosis, kinase regulation, and development\u2014without a clear, single functional theme. The zero edges also indicate no apparent direct interactions tying these proteins together, making a coherent, representative label inappropriate.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0000747","count":3}]},{"hash":"1380686701396459959","title":"Neuronal ion transport and synaptic signaling","description":"The cluster is enriched for GO terms related to sodium and potassium ion transmembrane transport, excitatory postsynaptic potentials, GABA signaling, and regulation of synaptic transmission, indicating proteins involved in neuronal signaling and ion channel activity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":8},{"id":"GO:0060079","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0001661","count":6},{"id":"GO:0007626","count":6}]},{"hash":"2135970099352114907","title":"Signaling Pathways and Telomere/Chromosome Maintenance","description":"This cluster blends GO terms from cell signaling (Wnt signaling, ephrin receptor signaling) with chromosomal processes (spindle assembly, telomere maintenance, chromosomal localization) and protein modification (ADP-ribosylation). The shared theme appears to be coordination between signal transduction and chromosome/thymomere dynamics, leading to a cohesive but broad functional group.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900383","count":7},{"id":"GO:1904908","count":7},{"id":"GO:0071901","count":7},{"id":"GO:0070198","count":7},{"id":"GO:0051225","count":7}]},{"hash":"1351869028152602292","title":"Wnt and MAPK signaling with cytoskeletal regulation","description":"Proteins in this cluster are enriched for signaling pathways (Wnt, ERK/MAPK, Eph/ephrin) and for cytoskeletal dynamics (focal adhesion, actin remodeling), suggesting a cohesive role in signaling-controlled cytoskeletal regulation, despite some obsolete terms present. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":11},{"id":"GO:0070374","count":10},{"id":"GO:0043552","count":10},{"id":"GO:0000186","count":10},{"id":"GO:0043304","count":10}]},{"hash":"893602894417511810","title":"Developmental signaling and morphogenesis","description":"This cluster\u2019s top GO terms center on development, differentiation, and tissue morphogenesis (e.g., spermatid differentiation, spindle assembly, placental morphogenesis, EMT in endocardial cushion formation) with supporting roles for Wnt signaling and apoptotic pathways. The diverse set suggests a broad developmental theme rather than a single precise function, so a general label around developmental signaling and morphogenesis is most representative.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007289","count":5},{"id":"GO:0051225","count":5},{"id":"GO:0097190","count":4},{"id":"GO:0003198","count":3},{"id":"GO:0061000","count":3}]},{"hash":"1431408971926163569","title":"Neuronal signaling and behavior","description":"These terms cluster around neural signaling and synaptic function, including excitatory postsynaptic potentials, sodium and potassium ion transport, and GABA, acetylcholine, and norepinephrine pathways, along with innervation and behaviors such as locomotion and conditioned taste aversion. This pattern points to a cohesive role in neuronal communication and behavior regulation.","confidence":"High","size":15,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":13},{"id":"GO:0071805","count":13},{"id":"GO:0035725","count":13},{"id":"GO:0001661","count":12},{"id":"GO:0007626","count":12}]},{"hash":"1567284876978748865","title":"Synaptic signaling and sensory perception","description":"The proteins cluster around neural communication and sensory processing: excitatory postsynaptic potentials, sodium/potassium ion transport and membrane depolarization, GABA signaling, and sensory modalities such as sound and taste, with related behavioral terms like locomotion. An acrosome reaction term is present but does not override the dominant neuronal signaling/theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0035725","count":9},{"id":"GO:0001661","count":8},{"id":"GO:0007626","count":8}]},{"hash":"1863082109172461517","title":"Pain and Temperature Sensing Signaling","description":"The top GO terms cluster around sensory perception of pain and cellular response to temperature stimulus, with related signaling processes (calcium signaling, membrane potential regulation, cGMP signaling) and thermogenesis, suggesting a module focused on nociceptive/thermosensory signaling and associated signaling pathways, with possible developmental context.","confidence":"Medium","size":15,"edges":6,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0002024","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0042391","count":9},{"id":"GO:0051592","count":7}]},{"hash":"2004577607775302947","title":"Vertebrate development and RA signaling","description":"This cluster\u2019s top GO terms center on vertebrate development (heart, retina, uterus), retinoic acid\u2013related responses, and signaling/transcription regulation (ephrin signaling, DNA-templated transcription, RNA polymerase II elongation). This pattern suggests a cohesive group of proteins involved in developmental processes and RA-mediated transcriptional control, with additional regulatory aspects like protein methylation and cell cycle during development.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0010842","count":2},{"id":"GO:0006479","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0000278","count":2}]},{"hash":"15851442608972552","title":"Fucosylation-Linked Development and Immune Signaling","description":"The cluster is dominated by glycosylation-related terms\u2014Lewis a epitope biosynthesis, L-fucose catabolic process, N-glycan fucosylation, and general protein glycosylation\u2014suggesting a focus on fucosylation pathways. It also includes development-related terms such as Notch signaling, imaginal disc-derived leg segmentation, and neuronal stem cell maintenance, as well as neuron migration terms, indicating roles in developmental processes. Immune-related terms like leukocyte migration and CD4-positive regulatory T cell differentiation further point to immune signaling contexts. Taken together, these terms point to a theme where glycosylation, especially fucosylation, modulates development and immune signaling across species, hence the label.","confidence":"Medium","size":15,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":4},{"id":"GO:0002522","count":3},{"id":"GO:0042355","count":3},{"id":"GO:0021799","count":3},{"id":"GO:0036071","count":3}]},{"hash":"336464171990668114","title":"Organelle inheritance and vesicle trafficking","description":"These terms cluster around inheritance of intracellular organelles (vacuole, peroxisome, Golgi) and membrane trafficking processes (vesicle docking, exocytosis), plus membrane addition during cytokinesis and related cell-surface remodeling. Together they suggest a theme of coordinating organelle inheritance with vesicle trafficking during cell division and epithelial maturation, with some peripheral terms related to cell migration and reproduction. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048496","count":5},{"id":"GO:0000011","count":5},{"id":"GO:0045033","count":4},{"id":"GO:0006930","count":4},{"id":"GO:0007107","count":4}]},{"hash":"1696619127722635041","title":"GPCR-Neuropeptide Signaling with ERK-Calcium Regulation","description":"Top GO terms indicate GPCR signaling, neuropeptide signaling, calcium import, and ERK1/2 cascade regulation, suggesting a cluster centered on GPCR-driven signaling and downstream calcium/ERK pathways. While metabolic terms appear, they seem ancillary to the primary signaling theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010513","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0090280","count":4},{"id":"GO:0031953","count":4},{"id":"GO:0015768","count":4}]},{"hash":"719841921040314463","title":"Neural development and synaptic signaling","description":"This cluster is driven by neural-related terms such as cerebellum development and excitatory postsynaptic potential, pointing to involvement in neural development and synaptic activity. The other terms touch on transcriptional regulation, protein binding, and ribosome biogenesis, suggesting a broader regulatory context that supports neural functions. Taken together, the strongest neural signals justify naming it around neural development and synaptic signaling, with moderate confidence due to the presence of non-neural regulatory terms. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035067","count":3},{"id":"GO:0021549","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0042254","count":2},{"id":"GO:1903364","count":2}]},{"hash":"1899432442448650175","title":"Synaptic Transmission and Memory-Related Proteins","description":"This cluster is dominated by neuronal/synaptic terms, notably neurotransmitter secretion, synaptic vesicle clustering, and memory-related processes (including optomotor response). There are additional hints of cytoskeletal remodeling and gene regulatory processes (cell shape regulation, DNA binding regulation, and mRNA modification), but the strongest shared theme centers on synaptic function and memory-related activity.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007269","count":2},{"id":"GO:0007613","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0055003","count":2},{"id":"GO:0008360","count":2}]},{"hash":"1973191976215890409","title":"Glutamatergic Synaptic Signaling and Plasticity Regulation","description":"The Top Terms center on neuronal signaling: glutamatergic synaptic transmission, forebrain development, and regulation of small GTPases (Rho/Ras) affecting cytoskeletal dynamics and plasticity. Although there are immune-related complement terms present, the core shared theme appears to be neuronal communication and synaptic plasticity regulation, tied together by GTPase-mediated signaling pathways.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0035249","count":5},{"id":"GO:0031914","count":5},{"id":"GO:0006958","count":5},{"id":"GO:0038028","count":4}]},{"hash":"1346735395695111749","title":"GPCR Neurotransmitter Signaling and Vasoconstriction","description":"This cluster centers on GPCR-mediated signaling driven by neuropeptide and dopamine receptors, including activation of ERK cascades, and links to vascular responses such as vasoconstriction, prostaglandin signaling, and inflammatory/pain-related processes. Although there is also a xenobiotic and coagulation-related signal, the dominant theme is GPCR-driven neurotransmitter signaling impacting vascular and inflammatory contexts.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007218","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0042493","count":5}]},{"hash":"1662039269940563518","title":"Rho/Rac-regulated actin cytoskeleton dynamics","description":"These proteins are tied to Rho family GTPase signaling (Rho and Rac), actin cytoskeleton organization, and GTPase activation including ruffle assembly. The dominant GO terms point to cytoskeletal remodeling and cell spreading driven by Rho/Rac pathways, making this the most coherent functional theme for the cluster, despite a few unrelated terms like placenta development or NK T cell differentiation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0030036","count":3},{"id":"GO:0090630","count":3},{"id":"GO:0097178","count":2},{"id":"GO:1900026","count":2}]},{"hash":"817512788335907752","title":"Clathrin-dependent endocytosis and MVB sorting","description":"The terms cluster around clathrin-mediated endocytosis, vesicle cargo loading, and endosomal transport to the vacuole via multivesicular body sorting pathways, indicating a cohesive vesicle trafficking/endocytosis theme. Actin remodeling terms with Arp2/3 and cortical patch assembly likely reflect cytoskeletal support for these processes; a few older protease-related terms seem less informative for the current cluster focus.","confidence":"High","size":14,"edges":26,"triangles":9,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0034316","count":5},{"id":"GO:0006919","count":5},{"id":"GO:0000147","count":5},{"id":"GO:0000742","count":4},{"id":"GO:0032511","count":4}]},{"hash":"592391550147327862","title":"MAPK signaling and neural development","description":"This cluster centers on ERK1/ERK2 and p38MAPK cascades, indicating MAPK signaling. Coupled with forebrain and multicellular organism development terms and transcription-related terms, it suggests these proteins regulate development through MAPK-driven transcriptional control. The cluster thus reflects MAPK-mediated signaling relevant to neural development and gene expression.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030900","count":5},{"id":"GO:0070371","count":5},{"id":"GO:0038066","count":5},{"id":"GO:1904628","count":5},{"id":"GO:0097011","count":5}]},{"hash":"307184947269736882","title":"Nucleotide salvage and cofactor biosynthesis","description":"Dominant signals are nucleotide salvage (UMP/AMP/purine ribonucleoside salvage, inosine/uridine catabolism) and cofactor biosynthesis (biotin, menaquinone), suggesting a metabolic cluster focused on small-molecule metabolism; immune-related terms appear as potential annotation noise and do not define the core theme.","confidence":"Medium","size":14,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":4},{"id":"GO:0017000","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0044206","count":2},{"id":"GO:0006148","count":2}]},{"hash":"1708131722464440300","title":"Mitotic Regulation and Cytoskeletal Dynamics","description":"The prominent GO terms center on mitosis (mitotic spindle assembly; mitotic cell cycle), kinase signaling (positive regulation of GTPase activity; positive regulation of protein serine/threonine kinase activity; positive regulation of protein autophosphorylation), plus actin filament depolymerization and mRNA transport. This suggests a cohesive cluster focused on cell division control and cytoskeletal remodeling, with ancillary roles in development and hypoxic response.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0090307","count":6},{"id":"GO:0071902","count":6},{"id":"GO:0031954","count":6},{"id":"GO:0051028","count":6}]},{"hash":"830430500484367706","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":10},{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0000463","count":8},{"id":"GO:0071031","count":8}]},{"hash":"18279971302814956","title":"Core energy metabolism and fatty acid biosynthesis","description":"The cluster is enriched with central metabolism terms (glycolysis, TCA cycle) and fatty acid biosynthesis (including malonyl-CoA), suggesting a cohesive module for energy production and lipid synthesis; auxiliary terms like antibiotic biosynthesis or starvation response appear less central to the primary function.","confidence":"High","size":14,"edges":89,"triangles":341,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006096","count":2},{"id":"GO:0014823","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0006633","count":2},{"id":"GO:0006814","count":2}]},{"hash":"448292178281095694","title":"Neurodevelopment and cytokine signaling","description":"Top terms point to neural development processes (neurogenesis, axon regeneration, dendrite patterning, interneuron migration) and cytokine signaling (Th2 cytokine production, IL-27 signaling, STAT activation). This suggests a cluster centered on nervous system development with associated immune signaling interactions, rather than a single, narrow function. Hence the label Neurodevelopment and cytokine signaling.","confidence":"Medium","size":14,"edges":86,"triangles":306,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035745","count":9},{"id":"GO:0070106","count":9},{"id":"GO:0042517","count":9},{"id":"GO:0001751","count":8},{"id":"GO:0070593","count":8}]},{"hash":"666886133365627121","title":"Embryonic nervous system and endocrine organ development","description":"The top GO terms cluster around development of nervous system structures (cerebellum, motor neurons, forebrain) and endocrine glands (thyroid, pituitary), with additional embryonic organogenesis signals. This suggests a coherent theme of embryonic patterning and organ formation, dominated by neural and gland development, hence the chosen label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048706","count":2},{"id":"GO:0021524","count":2},{"id":"GO:0021549","count":2},{"id":"GO:0035116","count":2},{"id":"GO:0030878","count":2}]},{"hash":"2026097290649644641","title":"Neural development and synaptic remodeling","description":"The proteins show a coherent neural theme: nervous system development, midbrain dopaminergic neuron differentiation, regulation of neuron maturation, and modification of synaptic structure, complemented by GPCR signaling and endocytosis. While a few terms (apolipoprotein A-I signaling, regulation of kidney size) are broader, the dominant signal is neuronal development and synaptic function, suggesting this cluster centers on neural differentiation and synaptic remodeling rather than non-neural processes. The lack of observed interactions does not diminish the GO-driven functional coherence.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0099563","count":14},{"id":"GO:0014041","count":14},{"id":"GO:0045792","count":14},{"id":"GO:0038027","count":14},{"id":"GO:0007186","count":14}]},{"hash":"411252814191174256","title":"Male reproductive development and steroid signaling","description":"The top GO terms cluster around prostate gland development, male sex differentiation, and steroid hormone receptor complex assembly, suggesting a theme of male reproductive development and hormone signaling. The other terms (innate immune response, inflammatory regulation, and hyaluronan metabolism) may reflect tissue remodeling and inflammation commonly linked to prostate biology, but the core signal is hormone-driven male development. ","confidence":"Medium","size":14,"edges":25,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006463","count":2},{"id":"GO:0046661","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0030850","count":2}]},{"hash":"1222881088628961979","title":"Neural development and synaptic signaling","description":"This cluster is dominated by GO terms related to nervous system development, neuronal signaling, and axon guidance (nervous system development; smoothened signaling; roundabout signaling; regulation of synaptic transmission and plasticity), pointing to a coherent theme of neural development and synaptic function. Some terms like kidney development and immune pathways appear but are less central to the core theme.","confidence":"High","size":14,"edges":58,"triangles":102,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":13},{"id":"GO:0001822","count":13},{"id":"GO:0007224","count":12},{"id":"GO:0048873","count":12},{"id":"GO:0050852","count":12}]},{"hash":"1125121637429565952","title":"KIT-PI3K Signaling in Development and Angiogenesis","description":"This cluster centers on growth factor signaling and developmental processes. The prominent GO terms include KIT signaling pathway, positive regulation of PI3K/AKT signaling, and angiogenesis, indicating a core role in growth and vascular development. Additional terms point to broader development and remodeling programs (thyroid gland development, axon regeneration) and general signaling responsiveness (PMA response, leukocyte chemotaxis). Overall, the proteins likely participate in KIT/PI3K-driven signaling networks that drive development and tissue remodeling.","confidence":"High","size":14,"edges":40,"triangles":41,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048679","count":14},{"id":"GO:0002688","count":14},{"id":"GO:0042698","count":14},{"id":"GO:0038109","count":14},{"id":"GO:1902002","count":14}]},{"hash":"241562247205946665","title":"Immune signaling and actin cytoskeleton regulation","description":"Based on the top GO terms, the cluster is enriched for immune-related signaling (lipopolysaccharide response, T cell receptor signaling, GM-CSF stimulus) and actin cytoskeleton organization. DNA-templated transcription suggests transcriptional regulation of these pathways. Although neuronal terms appear (cerebellar cortex formation, axon regeneration), they likely reflect shared cytoskeletal regulation rather than a distinct neuronal identity. Overall, the proteins seem engaged in immune activation and cytoskeletal remodeling.","confidence":"Medium","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0071222","count":11},{"id":"GO:0050852","count":10},{"id":"GO:2001275","count":9},{"id":"GO:0097011","count":9}]},{"hash":"326522560961675691","title":"Developmental Growth Signaling","description":"This cluster features GO terms tied to signaling pathways that regulate growth, development, and tissue remodeling: KIT signaling, PI3K/AKT pathway, angiogenesis, thyroid development, ovulatory processes, axon regeneration, and responses to PMA. The common thread is activation of cell signaling cascades guiding development and differentiation, suggesting this cluster represents developmental signaling networks rather than a single narrow function.","confidence":"Medium","size":14,"edges":44,"triangles":56,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048679","count":13},{"id":"GO:0002688","count":13},{"id":"GO:0042698","count":13},{"id":"GO:0038109","count":13},{"id":"GO:1902002","count":13}]},{"hash":"2117633551440365307","title":"Clathrin-mediated endocytosis and actin-driven cell migration","description":"The prominent GO terms center on clathrin-dependent endocytosis, vesicle coating, and intracellular transport, with supporting actin remodeling such as lamellipodium assembly and actin filament bundles. Additional terms about cell migration, epithelial polarity, and convergent extension suggest coordinated endocytosis and cytoskeletal dynamics underlying developmental cell movements. ","confidence":"High","size":14,"edges":3,"triangles":0,"max_degree":1,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0072583","count":3},{"id":"GO:0016183","count":3},{"id":"GO:0006886","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0006368","count":2}]},{"hash":"1208178989953457088","title":"Neural development and adhesion signaling","description":"A majority of terms point to neural development processes (neuron projection development, dendrite regeneration, PNS myelination) and cell\u2013cell adhesion with associated cytoskeletal signaling (homophilic adhesion, regulation of Rho signaling, ECM remodeling). While there are a few outliers related to immune regulation and miscellaneous processes, the central theme appears to be neuronal growth/maturation coordinated with adhesion and cytoskeletal dynamics.","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043031","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0035023","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0031175","count":2}]},{"hash":"152716290673662149","title":"Cardiovascular and cartilage development","description":"This cluster is enriched for terms tied to heart development and cartilage condensation, along with broader multicellular development and growth. Coupled with signaling-related terms (PI3K/AKT regulation, GTPase activity) this suggests a coordinated developmental program governing heart and skeletal/cartilage formation rather than a metabolic or immune response role.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001502","count":5},{"id":"GO:0071226","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0043547","count":5}]},{"hash":"1451341974537765218","title":"RNA Processing and RNA Interference","description":"Based on the GO terms, this cluster centers on RNA metabolism and gene silencing: translation, rRNA processing and turnover, and RNA interference pathways (RISC assembly, primary miRNA processing, and siRNA processing). This combination points to proteins involved in RNA maturation and translational control, with small RNA\u2013mediated silencing as a key theme. A few terms related to dosage compensation and spinal cord morphogenesis appear less relevant, likely annotation noise rather than core features.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0045071","count":3},{"id":"GO:0009047","count":3},{"id":"GO:0035087","count":3},{"id":"GO:0031053","count":3}]},{"hash":"1016736079295815463","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017196","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0080163","count":2},{"id":"GO:0031426","count":2},{"id":"GO:0006744","count":2}]},{"hash":"1139087187318787013","title":"Plant methionine/one-carbon metabolism and glyoxylate cycle","description":"These terms cluster around methionine cycling (L-methionine catabolic process, SAM biosynthetic process, methionine cycle) and one-carbon metabolism, plus glyoxylate cycle and oxaloacetate metabolism, with supporting plant-specific processes like photorespiration regulation and hypoxia response. The grouping suggests a cohesive plant metabolic module centered on methionine/one-carbon metabolism linked to glyoxylate cycling.","confidence":"High","size":14,"edges":80,"triangles":256,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006107","count":6},{"id":"GO:0009087","count":6},{"id":"GO:0006556","count":6},{"id":"GO:0006730","count":6},{"id":"GO:0033353","count":6}]},{"hash":"114531371830181386","title":"Immune Signaling and Stress Response","description":"The cluster\u2019s top GO terms are dominated by immune-related processes: cellular response to lipopolysaccharide, cellular response to granulocyte macrophage colony-stimulating factor stimulus, and T cell receptor signaling, indicating an emphasis on immune signaling and stress responses. Other terms (DNA replication/transcription, xenobiotic response, and endothelial/membrane targeting) suggest broader housekeeping or context-specific roles, but the immune-related functions provide the clearest common thread among the proteins. ","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0006351","count":3}]},{"hash":"382203677249195140","title":"Complement-mediated immune activation","description":"The proteins co-occur with several immune-related GO terms: complement activation (lectin and classical pathways), leukocyte tethering/rolling, regulation of T cell homeostasis, platelet activation, and PKC signaling, indicating a cohesive theme of immune activation and complement-driven processes. A couple of terms (Purkinje cell layer development and thyroid hormone generation) appear less connected and may reflect background associations. Overall, the cluster centers on immune response and complement pathways.","confidence":"Medium","size":14,"edges":6,"triangles":1,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0050901","count":6},{"id":"GO:0010572","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0001970","count":5},{"id":"GO:0021680","count":4}]},{"hash":"492344424225557256","title":"Developmental Transcriptional Regulation","description":"This cluster centers on transcriptional control (DNA-templated transcription and regulation of transcription initiation) and includes multiple tissue- and organ-development terms (trachea cartilage, Harderian gland, prostate glandular acinus, ovarian follicle growth, gonad development, heart morphogenesis, and overall multicellular growth), suggesting a unifying theme of transcription-driven development and organ differentiation, with circadian regulation as an additional transcriptional process.","confidence":"Medium","size":14,"edges":20,"triangles":8,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0070384","count":7},{"id":"GO:0060528","count":7},{"id":"GO:0017055","count":7},{"id":"GO:0060534","count":7}]},{"hash":"230565111870212852","title":"Multisubstrate Membrane Transport","description":"The top GO terms indicate transport across the membrane for a diverse set of substrates (vitamins, sugars like glucose and trehalose, xenobiotics, organic anions, lactose, selenite) and an osmotic stress response, all pointing to a cluster of transport proteins with broad substrate specificity. The outlier term related to replicative senescence is unlikely to define the core function of the cluster. ","confidence":"High","size":14,"edges":86,"triangles":307,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":13},{"id":"GO:0035461","count":13},{"id":"GO:0006855","count":13},{"id":"GO:1904728","count":12},{"id":"GO:1904659","count":12}]},{"hash":"2245979160584027462","title":"Multi-lineage development and cell differentiation","description":"This cluster centers on differentiation and development across a wide range of tissues\u2014astrocytes, skeletal muscle, pancreas, neurons, oligodendrocytes, inner ear cells, and heart valve formation\u2014suggesting a general theme of lineage specification rather than a single tissue type. Transcription by RNA Pol II appears as a broad regulatory background, with one outlier immune term present but not dominating the pattern. Thus the label reflects the dominant function of developmental differentiation across multiple lineages.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0048712","count":9},{"id":"GO:2001038","count":9},{"id":"GO:0035914","count":9},{"id":"GO:0031018","count":9}]},{"hash":"1213607696231375318","title":"Splicing and Translation Initiation Regulation","description":"The cluster is enriched for spliceosome-mediated mRNA splicing (core splicing, regulatory splicing), mRNA processing and modification, stress-associated mRNA stability, and assembly of translation initiation machinery (preinitiation complex and eIF4F). This points to a cohesive role in RNA processing and the initiation of translation, rather than unrelated processes.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0045292","count":7},{"id":"GO:0048025","count":7}]},{"hash":"1792049646626179556","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0085020","count":8},{"id":"GO:0042787","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0070534","count":8}]},{"hash":"1765063782515569214","title":"Cell stress signaling with apoptosis and immune modulation","description":"Top GO terms indicate apoptotic pathways, oxidative stress responses, and B cell signaling, plus vesicle transport and PKC-related signaling, suggesting a general cell-stress\u2013driven signaling theme affecting survival and immune activity, with some neuronal context included.","confidence":"Medium","size":14,"edges":12,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0002037","count":2},{"id":"GO:0008631","count":2},{"id":"GO:0010917","count":2},{"id":"GO:0002337","count":2}]},{"hash":"314792660045388986","title":"Lineage differentiation and transcription","description":"The terms point to differentiation across multiple lineages (brown fat, macrophages, hepatocytes, plasma cells) and broad transcriptional activity (RNA polymerase II), with accompanying lipid metabolism signals, suggesting proteins coordinating lineage-specific differentiation via transcriptional programs.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:2000347","count":9},{"id":"GO:0050873","count":9},{"id":"GO:0030225","count":9},{"id":"GO:0035356","count":9}]},{"hash":"1769947826584823735","title":"Neural and sensory organ development","description":"The cluster\u2019s top GO terms cluster around neural lineage specification and brain/sensory system morphogenesis (subpallium neuron fate commitment, regulation of subpallium differentiation timing, midbrain-hindbrain boundary morphogenesis, oligodendrocyte development, auditory receptor cell fate determination, inner ear differentiation). This points to a cohesive theme of neural and sensory cell development across forebrain and hindbrain regions, with some hints of broader morphogenetic processes. A couple terms (humoral immune response and androgen signaling) are less aligned and may be less central to the core function of the cluster, but do not overwhelm the primary neural/sensory theme.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060163","count":14},{"id":"GO:2000981","count":14},{"id":"GO:2000802","count":14},{"id":"GO:0014003","count":14},{"id":"GO:0006959","count":14}]},{"hash":"1948771201972957485","title":"Gonad-kidney organogenesis with angiogenesis","description":"In this cluster, several strong GO signals point to reproductive (germ cell migration, ovarian follicle development) and renal (branching morphogenesis of the ureteric bud) development, coupled with vascular remodeling (endothelial cell proliferation and migration in angiogenesis) and regulatory signaling pathways (BMP, TGF-\u03b2, ERK, NF-\u03baB). This suggests a theme of coordinated development of gonads and kidneys with associated vascularization. ","confidence":"Medium","size":14,"edges":16,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0008354","count":4},{"id":"GO:0001658","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0002043","count":4},{"id":"GO:0043536","count":4}]},{"hash":"1535597135994975735","title":"Dopaminergic neuron development and synaptic remodeling","description":"The term set centers on neuronal development and synaptic function: midbrain dopaminergic neuron differentiation, regulation of neuron maturation, and modification of synaptic structure, along with GPCR signaling and endocytosis that underpin synaptic activity. While a few terms touch on autophagy and non-neuronal processes, the dominant theme is neuronal development and synaptic regulation, making this label representative and coherent.","confidence":"High","size":14,"edges":10,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035900","count":14},{"id":"GO:0099563","count":13},{"id":"GO:0034497","count":13},{"id":"GO:0014041","count":13},{"id":"GO:0045792","count":13}]},{"hash":"1799142224864372756","title":"RNA processing and mitochondrial protein import","description":"Several top GO terms cluster around gene expression processes (mRNA splicing, translation, phenylalanyl-tRNA aminoacylation) and mitochondrial function (protein import into mitochondrial matrix, regulation of mitochondrial membrane permeability). Although a few terms reference cell cycle and other processes, the dominant pattern points to RNA processing and mitochondrial protein handling as a shared theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:2000134","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0070940","count":2},{"id":"GO:0010867","count":2}]},{"hash":"2240245436291719641","title":"RNA processing and ribosome biogenesis with TOR signaling","description":"This cluster shows strong representation of mRNA splicing, mRNA transport, ribosome biogenesis, translation initiation and reinitiation, RNA cap methylation, and TORC1 signaling, suggesting an integrated module coordinating RNA processing with ribosome assembly and translation control under TOR pathway regulation.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":10},{"id":"GO:0042254","count":10},{"id":"GO:0051028","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0043547","count":9}]},{"hash":"682630541041357579","title":"Antiviral and phagocytic immune response with apoptosis","description":"The top GO terms cluster around immune defense and cell turnover: defense response to virus, adaptive immune response, neutrophil chemotaxis, phagocytosis, and apoptotic processes, with ubiquitin-dependent protein catabolic activity linking protein turnover to immune signaling; together they suggest coordinated antiviral defense and programmed cell death in immune contexts.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0006909","count":3}]},{"hash":"848646542162418010","title":"Unknown","description":"The Top Terms cover a broad mix of signaling (vitamin D receptor, cAMP, insulin signaling), muscle-related processes (cardiac contraction), neural/myelination, transcription elongation, and proteostasis, with no single cohesive function or interaction pattern tying them together. Edges are absent, and several terms are obsolete, suggesting the cluster lacks a clear, unified biological theme.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070562","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0060048","count":2}]},{"hash":"322295037305477328","title":"GPCR Signaling in Vision and Dopaminergic Pathways","description":"The cluster repeatedly features GO terms tied to G protein-coupled receptor signaling across both vision (opsin-mediated signaling, visual perception, visual learning) and dopaminergic neurotransmission (synaptic transmission, cocaine behavioral response), with downstream ERK cascade regulation and GPCR internalization. The inclusion of prostaglandin receptor signaling and macrophage chemotaxis further supports a unifying GPCR-centric mechanism. This makes the GPCR-driven neural signaling theme a concise and representative label.","confidence":"High","size":14,"edges":75,"triangles":214,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":14},{"id":"GO:0070374","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0010759","count":14},{"id":"GO:0008542","count":14}]},{"hash":"2166859581897701162","title":"Embryonic neural and organ development","description":"The top GO terms point to broad embryonic development across neural structures (rhombomere, subpallium, globus pallidus, peripheral neurons) and organogenesis (somite formation, ureteric bud branching, pancreatic cell fate), suggesting a general theme of developmental patterning and cell fate specification rather than a single pathway. ","confidence":"Medium","size":14,"edges":15,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021570","count":14},{"id":"GO:2000288","count":14},{"id":"GO:0060163","count":14},{"id":"GO:0021723","count":14},{"id":"GO:0001757","count":14}]},{"hash":"1248606002420133637","title":"Unknown","description":"The top GO terms cover diverse developmental processes (forelimb and vagina development, neurogenesis, acrosome assembly) as well as metabolic and signaling pathways (glucose transport, insulin signaling/secretion, phospholipid homeostasis) and general gene regulation. These domains do not point to a single coherent function or pathway for the cluster, so a concise, representative label is not evident.","confidence":"","size":14,"edges":15,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035115","count":3},{"id":"GO:0022008","count":3},{"id":"GO:0015758","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0060068","count":3}]},{"hash":"819393069709267715","title":"Neural development and signaling","description":"This cluster centers on neural development and signal transduction, with GO terms highlighting ERK/MAPK cascade regulation, hedgehog and Slit-Robo pathways, regulation of synaptic vesicle exocytosis, and nervous system development, suggesting a coordinated set of proteins involved in neuronal signaling and development. Some terms also touch on broader growth and spermatid development, but the dominant theme is neural signaling.","confidence":"High","size":14,"edges":41,"triangles":38,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0033138","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0035264","count":4}]},{"hash":"1267728563808927462","title":"TLR signaling and LPS response","description":"The top GO terms cluster around Toll-like receptor signaling: TLR2/4/9 pathways, MyD88-dependent/independent routes, and downstream NF-kappaB/I\u03baB regulation, plus cellular response to lipopolysaccharide. This suggests a coherent module centered on innate immune sensing of bacterial components (LPS) and signaling to inflammatory transcription, with some hints of receptor trafficking via intracellular transport.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0034162","count":3},{"id":"GO:0034134","count":3},{"id":"GO:0034142","count":3},{"id":"GO:0006886","count":3},{"id":"GO:0010765","count":3}]},{"hash":"1987156176344574896","title":"Neural development and cytoskeletal signaling inhibition","description":"The top GO terms cluster around negative regulation of signaling and cytoskeletal processes (Rho/Rac signaling, stress fiber assembly, cell-matrix adhesion) together with nervous system development (peripheral myelination, sympathetic nervous system development). This points to a module of proteins that dampen cytoskeletal dynamics and adhesion during neural development. Some terms (e.g., amyloid-beta regulation) are less cohesive but do not override the dominant neural-cytoskeletal theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902430","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0035024","count":2},{"id":"GO:0001953","count":2}]},{"hash":"279336088576688490","title":"Rho GTPase\u2013driven cytoskeletal remodeling","description":"The top GO terms point to Rho GTPase\u2013regulated signaling and cytoskeletal dynamics (GTPase activity, Rho signaling, filopodium and stress fiber assembly, cell spreading) with involvement of ERK/MAPK signaling and ubiquitination, suggesting a coordinated program of cytoskeletal remodeling and adhesion during development. ","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0046847","count":3}]},{"hash":"1848377321830561871","title":"Cell growth, division, and translation","description":"The top GO terms cluster around core protein synthesis (ribosome biogenesis, arginyl- and glycyl-tRNA aminoacylation) and cell proliferation (cell division, negative regulation of proliferation), suggesting a focus on growth and production of proteins. Added signaling-related terms (GTPase activity, tyrosine phosphorylation, TGF-beta response) indicate regulatory pathways that fine-tune growth and division, with a secondary indication of innate immune signaling. Overall, the group centers on cellular growth and translation with regulatory signaling influences.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000747","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006420","count":2},{"id":"GO:0006426","count":2}]},{"hash":"2288690065680684147","title":"Rho GTPase signaling and cytoskeletal dynamics","description":"The cluster is enriched for small GTPase-mediated signaling terms and regulation of Rho protein signaling, pointing to Rho-family pathways that drive actin remodeling, cell movement, and mechanoresponse. Phagocytosis and neural development terms likely reflect downstream cytoskeletal processes and cell-type\u2013specific outputs, but the unifying theme is cytoskeletal dynamics governed by Rho GTPase signaling.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0006909","count":3}]},{"hash":"63209677713738895","title":"Wnt signaling in heart development and apoptosis","description":"The top GO terms are dominated by Wnt signaling and apoptotic process, with heart development also represented, suggesting a developmental signaling module focused on Wnt-driven heart formation and cell fate regulation. Other terms point to broader regulatory processes (transcriptional regulation, ubiquitination, and metabolic signaling), which may reflect ancillary connections to development and cellular regulation. Although not all terms fit perfectly, the core appears to center on Wnt-mediated developmental signaling and apoptosis. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0007269","count":3}]},{"hash":"1127084922890733150","title":"GPCR Signaling and Cardiac and Reproductive Development","description":"The Top Terms are dominated by GPCR-related processes (internalization, desensitization, acetylcholine receptor signaling) alongside cardiac-related terms (cardiac muscle contraction, heart development) and germline development terms (oogenesis, spermatogenesis, meiosis). This pattern suggests a theme of GPCR-regulated signaling impacting both cardiac and reproductive development, with additional related behaviors, so the label captures the main functional axes represented in the cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002031","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0008344","count":3},{"id":"GO:0048477","count":2},{"id":"GO:0007129","count":2}]},{"hash":"509290696527675508","title":"Proteoglycan GAG biosynthesis and sulfation","description":"The top GO terms are dominated by glycosaminoglycan synthesis pathways (heparan, chondroitin/dermatan, keratan sulfates) and protein sulfation, indicating a module focused on proteoglycan assembly and sulfation; the hormone metabolism terms are present but appear secondary.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":4},{"id":"GO:0015015","count":4},{"id":"GO:0030206","count":4},{"id":"GO:0006584","count":3},{"id":"GO:0030205","count":3}]},{"hash":"2029703018760818855","title":"Unknown","description":"The terms span stress responses (cadmium, arsenite, heat), apoptosis, transcription, and various regulatory processes, with no clear shared function or strong interactions among the proteins. Because there is no cohesive theme linking the GO terms, the cluster cannot be reliably labeled with a specific function.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":3},{"id":"GO:0071276","count":2},{"id":"GO:1903936","count":2},{"id":"GO:0034605","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1765965983998388377","title":"Dopaminergic signaling and sensory perception","description":"The terms cluster around neural signaling and sensory processing, notably dopaminergic synaptic transmission, cocaine-related behavioral responses, visual learning and perception, and pain perception. ERK pathway regulation and prostaglandin responses support neuronal signaling themes, with brain renin-angiotensin system and heart development hinting at broader neurocardiac contexts, but the dominant signal indicates brain sensory signaling.","confidence":"Medium","size":14,"edges":72,"triangles":191,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001963","count":9},{"id":"GO:0048148","count":9},{"id":"GO:0071380","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0008542","count":9}]},{"hash":"674473322777043114","title":"Ion transport and membrane potential regulation","description":"The cluster\u2019s top GO terms center on potassium and sodium ion transport across membranes and processes regulating membrane potential (including resting potential, repolarization, and responses to cAMP/cGMP). A skin development term appears, but the dominant signal is ion transport and membrane excitability, suggesting a cohesive theme of cellular electrical properties. ","confidence":"High","size":14,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":7},{"id":"GO:0043588","count":6},{"id":"GO:0098719","count":5},{"id":"GO:0010754","count":5},{"id":"GO:0071321","count":5}]},{"hash":"711308302438960434","title":"Plant cell wall biosynthesis and O-glycosylation","description":"These terms cluster around plant cell wall polysaccharide assembly and protein glycosylation, including homogalacturonan and glucuronoxylan biosynthesis, mucilage production, galactose metabolism, and O-linked glycosylation pathways, suggesting a cohesive function in cell wall construction and modification.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016266","count":3},{"id":"GO:0005978","count":3},{"id":"GO:0071555","count":3},{"id":"GO:0010417","count":2},{"id":"GO:0006012","count":2}]},{"hash":"978662482596382384","title":"Innate immune signaling and cellular stress","description":"The top GO terms point to NOD1 signaling and NF-kappaB regulation, along with stress-related processes such as cold response, hepatocyte apoptosis, and regulation of mRNA stability, plus proteasome assembly. Together these suggest a cluster involved in innate immune signaling and broader cellular stress responses, despite some obsolete terms.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0070427","count":3},{"id":"GO:0097284","count":3},{"id":"GO:0043488","count":3}]},{"hash":"649325080940791913","title":"Cytoskeleton remodeling and cell polarity signaling","description":"This cluster centers on cytoskeleton dynamics (actin filament bundle assembly and GTPase activity) and cell polarity signaling (epithelial polarity, Wnt pathway). While there is some functional diversity (endocytosis, mRNA processing), the dominant theme links actin/cytoskeletal remodeling with polarity cues, suggesting roles in organizing cell shape and signaling at membranes.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0051017","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0016055","count":3}]},{"hash":"2295492531726738207","title":"Glycinergic neurotransmission and amino acid transport","description":"The GO terms show a cohesive theme of amino acid transport and glycine-mediated signaling in neural contexts (glycine import/secretion, glycinergic synaptic transmission, taurine and leucine transport), along with related monoamine processes (dopamine catabolic process, serotonin uptake) and brain development (thalamus development, perineurial glial growth), suggesting a cluster focused on neural amino acid transport and glycine-based neurotransmission with developmental associations.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015734","count":5},{"id":"GO:0042066","count":4},{"id":"GO:0060012","count":4},{"id":"GO:0042420","count":4},{"id":"GO:0061537","count":4}]},{"hash":"50569887149818602","title":"Membrane signaling and immune regulation","description":"The cluster\u2019s top GO terms center on signaling at the cell surface and immune-related processes (ephrin receptor signaling, immunological synapse formation, complement activation, protein phosphorylation, Fas signaling regulation), suggesting a theme of membrane-based communication and immune modulation. The presence of ciliary-related terms (outer dynein arm assembly, cilium movement) hints at broader links between signaling and cellular organization, but the dominant pattern is membrane signaling and immune regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0001771","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0036158","count":1}]},{"hash":"1645940476470920502","title":"TLR-Mediated Innate Immunity with Cytoskeleton Remodeling","description":"The GO terms show strong enrichment for innate immune signaling via toll-like receptors (MyD88-dependent and Toll signaling) and production of inflammatory cytokines (IL-6, IL-18) with responses to fungal stimuli, indicating an innate immune activation theme. The concurrent actin filament network formation and barbed-end uncapping point to cytoskeletal remodeling often linked to signaling and immune cell responses. Although other terms (apoptotic signaling, RNA import) appear, they are less central to the core pattern observed here.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042771","count":4},{"id":"GO:0051639","count":4},{"id":"GO:0032741","count":4},{"id":"GO:0032755","count":4},{"id":"GO:0002755","count":4}]},{"hash":"422810491789598092","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006584","count":3},{"id":"GO:0030205","count":3},{"id":"GO:0018146","count":3},{"id":"GO:0006044","count":3},{"id":"GO:0042403","count":3}]},{"hash":"1276878114789983044","title":"Unknown","description":"The GO terms are highly diverse, spanning development (bone, smooth muscle), signaling (phosphatidylinositol-mediated, ABA-activated pathways), metabolism (phosphatidylcholine), transcription (RNA Pol III), proteolysis, and even fungal sporulation. This lack of a unifying biological theme or pathway suggests there isn\u2019t a coherent function defining this cluster, so a specific, representative label isn\u2019t evident.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0048745","count":3},{"id":"GO:0031321","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0045945","count":2}]},{"hash":"1398117575745245185","title":"Cardiac Muscle Contraction & Sarcomere Organization","description":"The top GO terms center on heart muscle function and sarcomere dynamics, with strong signals for cardiac muscle contraction, sarcomere organization, and regulation of heart rate, plus vascular smooth muscle aspects. This points to a cohesive cardiovascular muscle module involving contraction machinery and sarcomere assembly/regulation, despite a few peripheral terms like phototransduction or spicule insertion. Overall, the cluster likely reflects proteins involved in heart muscle contraction and sarcomere organization.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":8},{"id":"GO:1904706","count":7},{"id":"GO:0045214","count":7},{"id":"GO:0060298","count":7},{"id":"GO:0034609","count":7}]},{"hash":"1513506537823829269","title":"Mitochondrial and chloroplast transcription and ribosome assembly","description":"The top GO terms are dominated by mitochondrial transcription (including regulation and termination), plastid rRNA transcription, chloroplast organization, and mitochondrial ribosome assembly, which together point to a shared function in organelle gene expression and ribosome biogenesis. A few outliers like RNA splicing and signaling/nucleotide salvage terms are present but do not alter the overall theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008380","count":2},{"id":"GO:0006393","count":1},{"id":"GO:1903108","count":1},{"id":"GO:0042794","count":1},{"id":"GO:0009658","count":1}]},{"hash":"333451531481800249","title":"Immune signaling and phagocytosis regulation","description":"The top GO terms point to immune-related signaling and endocytic processes (cellular response to fungal origin, regulation of phagocytosis, receptor internalization) with modulation across several pathways (Rho, Ras, Wnt, TGF-beta) and broader signaling contexts (insulin signaling, osteoclast differentiation). This ensemble suggests a cluster of proteins that regulate immune receptor signaling and phagocytic/endocytic functions rather than a single linear pathway.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":9},{"id":"GO:0035023","count":8},{"id":"GO:0046580","count":8},{"id":"GO:0090263","count":8},{"id":"GO:0046676","count":8}]},{"hash":"1493870244580281271","title":"Redox Stress Response and Differentiation Signaling","description":"The top terms cluster around redox homeostasis and detoxification, an immune/stress angle, and differentiation/regeneration programs (myotube and fat cell differentiation, organ regeneration). PI3K/AKT signaling regulation links growth to these responses, with kinetochore localization hinting at cell-cycle involvement under stress. Collectively, they suggest a theme of stress-responsive regulation of differentiation and regeneration.","confidence":"Medium","size":13,"edges":39,"triangles":63,"max_degree":10,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0045454","count":5},{"id":"GO:2000255","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0031100","count":5}]},{"hash":"1645301224596799980","title":"Regulatory signaling and transport","description":"This cluster mixes terms for regulation of signaling pathways (positive regulation of GTPase activity, TORC1 signaling), intracellular transport (mRNA transport, NLS-bearing protein import into nucleus), and broader cellular processes (cell division, apoptosis, cell migration) along with some development-related terms (skin development, maintenance of animal organ identity) and vacuole fusion. The common theme is broad regulatory control over signaling and trafficking rather than a single clear function, so the label reflects this general convergence.","confidence":"Medium","size":13,"edges":7,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0051028","count":4},{"id":"GO:0043588","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0006607","count":3}]},{"hash":"2276757552014281615","title":"RNA processing and translation initiation","description":"We note that the cluster's top GO terms cluster around mRNA processing (mRNA modification, alternative splicing, splice site recognition, mRNA stabilization) and translation initiation (formation of translation preinitiation complex, eIF4F complex assembly, translation reinitiation). This suggests proteins in this cluster coordinate RNA maturation with translation initiation and reinitiation, indicating a cohesive RNA metabolism module linking RNA processing to translation control.","confidence":"High","size":13,"edges":76,"triangles":265,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0016556","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0097010","count":9},{"id":"GO:1902625","count":9},{"id":"GO:1905663","count":9}]},{"hash":"978999075713047343","title":"Transcription Regulation and Genome Maintenance","description":"This cluster centers on nuclear processes that govern gene expression and genome integrity, highlighted by positive regulation of RNA polymerase I\u2013mediated transcription and base-excision repair, along with signals related to cell-cycle control. While terms like memory and dense core granule exocytosis are present, the strongest theme is transcription regulation coupled with genome maintenance and cell-cycle regulation, suggesting a nuclear regulatory module. ","confidence":"Medium","size":13,"edges":26,"triangles":3,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0001302","count":6},{"id":"GO:1900087","count":5},{"id":"GO:0007613","count":4},{"id":"GO:0006284","count":4},{"id":"GO:0042994","count":4}]},{"hash":"450725975472690574","title":"Neuronal actin remodeling and synaptic vesicle regulation","description":"The cluster is centered on actin dynamics and Cdc42 signaling, with terms for actin polymerization, pseudopodium assembly, and regulation of synaptic vesicle exocytosis and endocytosis, indicating a coherent theme of actin-driven neuronal morphology and synaptic trafficking. Some terms like ossification and mitotic cell cycle are broader or less specific, but the dominant signal points to neuronal actin remodeling and vesicle regulation.","confidence":"High","size":13,"edges":71,"triangles":220,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":6},{"id":"GO:0031274","count":6},{"id":"GO:0032488","count":6},{"id":"GO:0030838","count":6},{"id":"GO:2000300","count":6}]},{"hash":"814102698050656235","title":"Developmental transcription and stress-response proteins","description":"This cluster\u2019s top GO terms cluster around development (skeletal system development, multicellular organism development, neural tube closure) and transcriptional regulation (DNA-templated transcription, regulation of gene expression). It also includes stress and defense-related terms (ER-stress\u2013induced apoptotic signaling, response to cadmium, defense response to Gram-positive bacteria), suggesting proteins that participate in developmental regulation while also responding to cellular stress. The lack of edges indicates functional annotation is inferred from GO terms rather than direct interactions. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0070208","count":5},{"id":"GO:0006349","count":4},{"id":"GO:0007275","count":4}]},{"hash":"856691122117099638","title":"Mesodermal development and cardiac differentiation","description":"This cluster is enriched for developmental terms, notably multicellular organism development, mesoderm formation, and cardiac muscle cell differentiation, suggesting a shared role in mesodermal/heart development. While there are also RNA processing and DNA repair terms among the top GO terms, these likely reflect general cellular maintenance rather than a unifying function. Overall, the developmental theme, especially toward mesoderm and heart formation, best captures the cluster\u2019s common function.","confidence":"Medium","size":13,"edges":9,"triangles":1,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0035372","count":3}]},{"hash":"1686815628112482594","title":"Neural development and sensory perception","description":"This cluster centers on neural development (axonogenesis of CNS projection neurons, photoreceptor differentiation) and sensory-related functions (sound perception), with supporting signals for cytoskeletal and adhesion regulation that shape neurite outgrowth and synapse plasticity, suggesting a cohesive theme of developing and modulating neural circuits in sensory systems.","confidence":"Medium","size":13,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0021952","count":2},{"id":"GO:0046329","count":2},{"id":"GO:0001751","count":2},{"id":"GO:0035023","count":2}]},{"hash":"2119585359977973905","title":"Growth Factor Signaling and Immune Cell Migration","description":"The GO terms point to a network of signaling responses to diverse stimuli (fungal origin, retinoic acid, insulin, TGF-beta), activation of key cascades (ERK, STAT), and processes related to cell signaling, migration, and morphogenesis (neutrophil chemotaxis, smooth muscle migration, branching in mammary gland), collectively indicating a cluster centered on growth factor\u2013driven signaling that also coordinates immune cell recruitment and tissue remodeling.","confidence":"High","size":13,"edges":56,"triangles":121,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071226","count":12},{"id":"GO:0071300","count":11},{"id":"GO:0060444","count":11},{"id":"GO:0042531","count":11},{"id":"GO:0014911","count":11}]},{"hash":"2043323712969628935","title":"Adaptive Immune Activation Signaling","description":"Based on the top GO terms, the cluster is enriched for adaptive immune processes such as adaptive immune response, B cell affinity maturation, and activated T cell proliferation, as well as type I interferon signaling and ERK cascade regulation, which point to immune cell activation and signaling. Additional terms like cellular defense, ephrin receptor signaling, store-operated calcium channel activation, and angiogenesis support an inflammatory immune context.","confidence":"High","size":13,"edges":17,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":7},{"id":"GO:0048013","count":7},{"id":"GO:0050798","count":7},{"id":"GO:0032237","count":7},{"id":"GO:0002250","count":6}]},{"hash":"593864026103271842","title":"Embryonic organogenesis and neural development regulators","description":"Based on the GO terms, the cluster centers on developmental processes across multiple embryonic tissues (kidney ureteric bud branching, pituitary and endocrine pancreas development, neural crest migration, spinal interneuron specification, hypothalamus and inner ear development). The concurrent transcription-related terms (DNA-templated transcription and negative regulation of RNA Pol II) suggest these proteins also modulate gene expression during development. This combination indicates a cohesive theme of embryonic organogenesis with neural and endocrine patterning, warranting a specific, development-focused label.","confidence":"Medium","size":13,"edges":51,"triangles":84,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090190","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0048557","count":7},{"id":"GO:0021983","count":7}]},{"hash":"1749644920765612081","title":"Neuronal receptor trafficking and ion transport","description":"The proteins show features of receptor internalization and clustering, receptor signaling via GTPases and guanylyl cyclase pathways, and ion transmembrane transport, plus synaptic/plasticity-related terms like LTD and sensory perception of sound, all pointing to neuronal receptor regulation and ion channel activity.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0043113","count":2}]},{"hash":"1348338952045228175","title":"Oxidative stress response and autophagy","description":"The cluster is dominated by terms for cellular stress responses (to hydrogen peroxide, metal ions, amino acid starvation) and multiple autophagy-related processes (reticulophagy, piecemeal microautophagy of the nucleus) plus apoptosis, indicating a theme centered on stress sensing and autophagic turnover; a few terms (morphine response, mucus secretion) appear peripheral or noisy. ","confidence":"Medium","size":13,"edges":70,"triangles":226,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":7},{"id":"GO:0043278","count":7},{"id":"GO:0010040","count":7},{"id":"GO:0070257","count":7},{"id":"GO:0034629","count":7}]},{"hash":"430869569697961191","title":"Translation and ribosome maturation","description":"The cluster is dominated by translation-related GO terms (translation, translational termination, regulation of translation) and rRNA maturation/RNA processing, suggesting proteins involved in protein synthesis machinery and ribosome biogenesis. Some chromatin-related terms are marked obsolete and likely noise. Overall, the theme centers on translational machinery and associated RNA processing.","confidence":"High","size":13,"edges":27,"triangles":27,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006415","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0043981","count":2},{"id":"GO:0001207","count":2}]},{"hash":"507252787890637477","title":"Neuroimmune signaling and neuronal development","description":"The terms combine innate immune pathways (MyD88-dependent TLR signaling, I\u03baB phosphorylation, JAK-STAT regulation) and cytokine production (IL-6, IL-18) with neuronal development processes (neuron maturation, branching morphogenesis) and cytoskeletal dynamics (actin filament network formation). This suggests a cluster centered on neuroimmune crosstalk affecting neural development, rather than a single narrow function, making the label representative though not exclusive.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1905289","count":1},{"id":"GO:0051639","count":1},{"id":"GO:2000172","count":1},{"id":"GO:0032741","count":1},{"id":"GO:0035751","count":1}]},{"hash":"1468821292648845368","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":13},{"id":"GO:0007626","count":13},{"id":"GO:0045216","count":12},{"id":"GO:0060901","count":12},{"id":"GO:0071681","count":12}]},{"hash":"2281950102238711813","title":"Calcium and Ion Homeostasis Signaling","description":"The terms cluster around intracellular ion regulation (calcium, sodium, potassium), including calcium transport and homeostasis, coupled with signaling pathways (PKA/cAMP) and modulatory processes (steroid hormone response). The presence of calcium handling and ion transport terms, plus neural development (vestibulocochlear nerve formation), points to a theme of ion-mediated signaling in cells, particularly related to calcium dynamics in neural contexts.","confidence":"Medium","size":13,"edges":51,"triangles":135,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:2000481","count":3},{"id":"GO:0071383","count":2},{"id":"GO:0021650","count":2},{"id":"GO:0002028","count":2},{"id":"GO:1901205","count":2}]},{"hash":"2033006755767160160","title":"Amino acid and cofactor biosynthesis","description":"The proteins are enriched for biosynthetic processes, including several amino acids (aspartate, alanine, tyrosine) and cofactors such as heme (via protoporphyrinogen IX), biotin, and cobalamin, plus related porphyrin biosynthesis. This points to a core function in producing essential metabolites; fatty acid homeostasis suggests broader metabolism but does not override the central biosynthetic theme.","confidence":"High","size":13,"edges":29,"triangles":21,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":3},{"id":"GO:0006783","count":3},{"id":"GO:0006532","count":2},{"id":"GO:0006523","count":2},{"id":"GO:0055089","count":2}]},{"hash":"1890010730210507793","title":"Tissue Development and Angiogenesis","description":"The top GO terms show broad developmental activities across tissues, with strong emphasis on angiogenesis and endothelial migration (GO:0045766, GO:0043277, GO:0043536), plus hypoxia response, bone mineralization, myoblast fusion, and keratinocyte differentiation, suggesting a general theme of tissue morphogenesis and vascular remodeling rather than a single specific function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":3},{"id":"GO:0072378","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0030500","count":3}]},{"hash":"1737373098627393210","title":"Synapse organization and cerebellar development","description":"This set shows strong signals for synapse organization (GO:0050808), receptor clustering (GO:0043113), and localization to adherens junctions, plus a cerebellar-specific term (Purkinje cell layer formation). Calcium transport and Rho signaling themes align with cytoskeletal dynamics at synapses, suggesting neuronal adhesion and assembly processes rather than a single narrow function. Some terms are generic or obsolete, indicating a broader neuronal adhesion/synapse module. Confidence: Medium.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0006508","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0035234","count":5},{"id":"GO:0050808","count":5}]},{"hash":"1719910227714069917","title":"Unknown","description":"This cluster's top GO terms cover immune-vascular signaling (endothelial chemotaxis, NK cell cytotoxicity), neural components (paranode localization, sodium channel clustering), metabolism (vitamin D3), viral attachment, development, and tumor detection. The functions are too heterogeneous to define a single coherent theme, so no reliable label can be assigned.","confidence":"","size":13,"edges":68,"triangles":196,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0038033","count":9},{"id":"GO:0002860","count":9},{"id":"GO:0002175","count":9},{"id":"GO:0045162","count":9},{"id":"GO:0070640","count":9}]},{"hash":"136663295860464951","title":"Embryonic neural and skeletal development","description":"The cluster is enriched for developmental processes (forebrain development, neural tube closure, skeletal system development, multicellular organism development) and DNA-templated transcription, suggesting a module coordinating embryogenesis and gene regulation; occasional stress-related terms and cell cycle signals are present but secondary.","confidence":"Medium","size":13,"edges":47,"triangles":79,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006349","count":11},{"id":"GO:0001403","count":11},{"id":"GO:0001501","count":11},{"id":"GO:0030900","count":11},{"id":"GO:0070059","count":11}]},{"hash":"1930233366162413126","title":"Neural development and sensory signaling","description":"The top GO terms cluster around nervous system development and sensory processes (inner ear development, pain perception, axon regeneration) and linked developmental signaling (KIT pathway). While a few terms pertain to leukocyte chemotaxis and reproductive cycles and some entries are obsolete, the dominant signal points to neural development and sensory function, justifying a neural/sensory cluster label.","confidence":"Medium","size":13,"edges":10,"triangles":1,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006349","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0048839","count":12},{"id":"GO:0007275","count":12},{"id":"GO:0048679","count":11}]},{"hash":"548596061459854450","title":"Proteoglycan Biosynthesis and Embryonic Development","description":"The top GO terms point to biosynthesis of proteoglycans (heparan sulfate, chondroitin, heparin) and key developmental processes (mesoderm formation, gastrulation, multicellular development) with links to FGFR signaling. This suggests a coherent theme where proteoglycans shape developmental signaling and morphogenesis, despite a couple of auxiliary terms related to stress or immune responses. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0070059","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0001707","count":3},{"id":"GO:0006486","count":3}]},{"hash":"653122940675101374","title":"Mitotic chromosome segregation machinery","description":"This cluster is dominated by GO terms tied to mitosis and chromosome alignment, including mitotic cell cycle, cell division, and chromosome passenger complex localization to the kinetochore, pointing to a mitosis/spindle/kinetochore function. Additional signals regarding Ran signaling and vesicle trafficking can intersect with dividing cells, but the core theme remains chromosome segregation in mitosis. ","confidence":"High","size":13,"edges":52,"triangles":108,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":13},{"id":"GO:0000278","count":13},{"id":"GO:0006547","count":12},{"id":"GO:0035330","count":12},{"id":"GO:0051036","count":12}]},{"hash":"794218287926208389","title":"Vertebrate muscle and craniofacial development","description":"This cluster is dominated by terms for skeletal muscle cell differentiation and myoblast differentiation, as well as craniofacial morphogenesis (roof of mouth development, viscerocranium) and neural crest\u2013derived lineages (melanocyte differentiation). Early developmental processes like primitive streak formation and transcriptional regulation (DNA-templated transcription), with calcium signaling, are also present, supporting a vertebrate embryogenesis theme. The plant-specific term appears to be an outlier. Overall, the core pattern points to vertebrate embryonic muscle and craniofacial differentiation as the main function.","confidence":"High","size":13,"edges":70,"triangles":211,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001016","count":8},{"id":"GO:0010076","count":7},{"id":"GO:0090009","count":7},{"id":"GO:0035914","count":7},{"id":"GO:0030318","count":7}]},{"hash":"509888110130305924","title":"Lipid Metabolism and Membrane Organization","description":"This cluster shows a strong representation of lipid metabolism (fatty acid catabolic process; galactolipid and triglyceride biosynthesis; lipid droplet organization) and membrane/organellar organization (endoplasmic reticulum organization; lamin depolymerization; nucleus organization). A few terms are more general (positive regulation of transcription by RNA polymerase II; G1/S cell cycle transition) and may reflect growth coordination, while teichoic acid biosynthesis seems discordant and may reflect annotation noise. Overall, the dominant theme is lipid biosynthesis and membrane dynamics, hence the proposed label. ","confidence":"Medium","size":13,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019350","count":2},{"id":"GO:0009062","count":2},{"id":"GO:0007078","count":2},{"id":"GO:0007029","count":2},{"id":"GO:0006997","count":2}]},{"hash":"1431780608529556046","title":"Glutamatergic synaptic transmission and memory","description":"The top GO terms cluster around neuronal signaling and memory, especially glutamatergic synaptic transmission, excitatory postsynaptic potentials, and calcium ion transport, with notes on short- and long-term memory and neuromodulatory responses (amphetamine, ethanol). While a couple terms are less related (developmental cytoskeleton polarity, granulocyte macrophage CSF response), the prevailing pattern points to synaptic communication and memory processes in neurons.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":7},{"id":"GO:0007614","count":7},{"id":"GO:0007616","count":7},{"id":"GO:0001975","count":7},{"id":"GO:0045471","count":6}]},{"hash":"738512383931701146","title":"FGF-MAPK signaling in organogenesis and angiogenesis","description":"This cluster centers on developmental processes with strong emphasis on FGF/FGFR and MAPK/ERK signaling (ERK cascade regulation, MAPKKK cascade via FGFR), alongside organogenesis, angiogenesis, branching morphogenesis, and multicellular development. The term pattern suggests a cohesive theme of FGF-MAPK\u2013driven organ and vascular development across tissues.","confidence":"High","size":13,"edges":66,"triangles":179,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0070374","count":6},{"id":"GO:0000187","count":6},{"id":"GO:2000546","count":6}]},{"hash":"1957029217005415030","title":"Neuronal signaling and auditory processing","description":"The top GO terms cluster around neural communication: excitatory and inhibitory synaptic transmission (glutamatergic and GABA signaling), ions channels for action potentials (sodium/potassium transport), and sensory aspects of hearing (sound perception, mechanical stimulus detection). Locomotory behavior and conditioned taste aversion suggest involvement in broader neural circuitry for behavior. Together these indicate a coherent group of proteins involved in neuronal signaling and auditory processing.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":10},{"id":"GO:0060079","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0035725","count":8},{"id":"GO:0001661","count":8}]},{"hash":"1129917723044076279","title":"Cell growth, division, and vesicular trafficking","description":"This cluster is enriched for terms tied to protein synthesis and the machinery of cell division, including ribosome biogenesis and translation initiation complex formation, as well as spindle assembly and progression through the mitotic cell cycle. It also includes vesicular transport steps from the ER to the Golgi and endosome-to-endosome routes, pointing to active intracellular trafficking. Though a few terms relate to development or defense, the strongest signals are core proliferative and trafficking processes, making the label appropriate.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0070893","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0001731","count":2}]},{"hash":"1734286120079128850","title":"Organ development signaling pathways","description":"The proteins are linked to multiple organ development terms (kidney, liver, nervous system) and central signaling networks (ERK/MAPK, SHH/SMO, EGFR) with RC/Rho signaling and cell division also represented. This pattern points to a cluster of factors coordinating developmental signaling across organs rather than a single tissue, hence a label centered on developmental signaling in organogenesis.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0070374","count":3}]},{"hash":"205665885173071769","title":"Glutamatergic synaptic signaling and plasticity","description":"The top GO terms are dominated by synaptic-related functions (glutamatergic transmission, long-term potentiation, and regulation of synaptic plasticity), pointing to a clear theme of neuronal synapse signaling and adaptive changes. Some terms relate to apoptosis regulation or lipid biosynthesis, which can modulate synapses, but the core cluster clearly centers on neural communication and plasticity.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007520","count":7},{"id":"GO:0034351","count":7},{"id":"GO:0035249","count":7},{"id":"GO:0009738","count":7},{"id":"GO:0060291","count":7}]},{"hash":"656093285242592154","title":"Vertebrate neural crest development and axon guidance","description":"The proteins are enriched for vertebrate development, especially neural crest\u2013derived processes such as branchiomotor neuron axon guidance, neural crest cell migration, sympathetic neuron projection guidance, trigeminal nerve organization, and axonal fasciculation. Although a complement activation term appears, the dominant pattern centers on neural development and broader organogenesis (bone maturation, kidney development). Therefore, the cluster is best described as vertebrate neural crest development and axon guidance.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0001822","count":6},{"id":"GO:0021785","count":6}]},{"hash":"607472100942952631","title":"ER Stress and Secretory Trafficking","description":"The top GO terms cluster around ER stress responses (endoplasmic reticulum unfolded protein response), vesicle trafficking from the ER (COPII-coated vesicle budding), and calcium homeostasis, with apoptosis as a downstream process. Rho/GTPase signaling may support cytoskeletal changes needed for trafficking, while some terms reflect immune modulation; overall, the core theme is ER stress and the secretory pathway linking to cell fate. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0035025","count":4},{"id":"GO:0045953","count":4},{"id":"GO:0044791","count":3}]},{"hash":"173642615627288072","title":"Developmental Regulation and Stress Responses","description":"The top GO terms cluster around transcription and development (DNA-templated transcription; multicellular organism growth and development; retina development) alongside diverse stress and defense themes (ER-stress\u2013related apoptotic signaling, cellular response to cadmium ion, defense response to Gram-positive bacteria) and related cellular processes (cell division, invasive growth under glucose limitation). This mix suggests proteins broadly involved in development and remodeling, with substantial participation in stress and immune-related responses, rather than a single, tightly defined pathway. Confidence in this being a coherent, specific theme is therefore Medium.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0035264","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0006349","count":4}]},{"hash":"1057163524572548338","title":"Glycinergic synapse function and glycine transport","description":"Based on the Top Terms, most proteins relate to glycinergic neurotransmission and glycine handling: glycine import, glycine secretion, glycinergic synaptic transmission, and regulation of glycinergic transmission. The neural context is reinforced by thalamus development and perineurial glial growth, while monoamine terms (serotonin uptake, dopamine catabolic process) likely reflect broader neural signaling rather than core function. Overall, the cluster appears to consist of components involved in glycine-mediated synaptic signaling and transport.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":5},{"id":"GO:0042066","count":4},{"id":"GO:0060012","count":4},{"id":"GO:0042420","count":4},{"id":"GO:0061537","count":4}]},{"hash":"1695324934265100440","title":"Unknown","description":"The top GO terms are scattered across stress and immune-related responses (heat, hydrogen peroxide, interferon-alpha) with no single shared function, and several terms are obsolete, so there isn\u2019t a coherent, representative theme for the cluster. ","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":1},{"id":"GO:0035457","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0070301","count":1},{"id":"GO:2001162","count":1}]},{"hash":"1735558641130859529","title":"Immune Activation and Vascular Remodeling","description":"The top GO terms cluster around immune signaling (interleukin-2 production, positive regulation of T cell differentiation) and extracellular matrix/vascular processes (collagen fibril organization, positive regulation of angiogenesis). Nucleotide salvage terms are present but likely reflect general metabolism rather than defining the cluster\u2019s core function. Thus, the proteins appear to be involved in coordinating immune responses with tissue remodeling and angiogenesis.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0044206","count":2},{"id":"GO:0006148","count":2},{"id":"GO:0070970","count":2}]},{"hash":"2077709346720525568","title":"Actin Cytoskeleton Remodeling and Mitosis","description":"The enriched terms center on actin cytoskeleton dynamics (Arp2/3 regulation, actin depolymerization), regulation of kinase and GTPase signaling, and cell division processes (mitotic spindle assembly, mitotic cell cycle), with supporting links to mRNA transport and neuronal projection development. This suggests a cohesive theme around cytoskeletal remodeling coordinating signaling and division. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034316","count":5},{"id":"GO:0071902","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0051028","count":4}]},{"hash":"1539322624963642626","title":"Actin-based Vesicle Transport and Golgi Organization","description":"The GO terms cluster around actin-driven processes (actin nucleation; vesicle transport along actin), membrane targeting, and Golgi organization (asymmetric Golgi ribbon formation; regulation of protein targeting to membrane), with related pigment granule transport and tight junction assembly. Together they suggest cytoskeleton-guided trafficking and polarized organelle organization, centered on actin dynamics and Golgi/polarized trafficking. ","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007118","count":6},{"id":"GO:0090314","count":6},{"id":"GO:2000810","count":6},{"id":"GO:0090164","count":5},{"id":"GO:0030050","count":5}]},{"hash":"1813887628941456129","title":"Lipid metabolism\u2013related myelination","description":"The cluster prominently features lipid handling terms (lipoprotein metabolic process, lipid transport) alongside myelination, suggesting a lipid-rich, myelin-associated biology. Additional terms like endothelial activation and developmental processes appear, but are less central to the core theme. Overall, the dominant signal points to lipid-associated myelin biology with some ancillary vascular/developmental annotations.","confidence":"Medium","size":12,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0042157","count":1},{"id":"GO:0042118","count":1},{"id":"GO:0006869","count":1}]},{"hash":"2046442146005943426","title":"Neural and muscular development with synaptic signaling","description":"The top GO terms point to development across tissues (multicellular organism development, heart development, Schwann cell development, myoblast fusion) and neural/synaptic function (excitatory postsynaptic potential, long-term potentiation, visual perception). This suggests proteins involved in neuromuscular and sensory tissue development with components of synaptic signaling and plasticity. A broad cell-cycle term appears less defining but can appear in developmental contexts. Therefore the cluster is best labeled as neural and muscular development with synaptic signaling.","confidence":"Medium","size":12,"edges":12,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0007520","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0014044","count":6}]},{"hash":"391694119812128789","title":"Vesicle trafficking and lysosome targeting","description":"The top GO terms cluster around intracellular transport: endosome to melanosome transport, retrograde Golgi-to-ER transport, and protein targeting to lysosome, along with regulation of GTPase activity and related trafficking processes. While cardiovascular and craniofacial development terms appear, the strongest common thread is vesicle transport and lysosomal targeting, suggesting a cohesive module of secretory/trafficking machinery. Confidence: Medium","confidence":"Medium","size":12,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0060047","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0050885","count":2},{"id":"GO:0033138","count":2}]},{"hash":"1751801666791563662","title":"Neuronal microtubule and mitochondrial dynamics","description":"The top GO terms point to microtubule polymerization and bundle formation, plus several mitochondrial-related processes such as fission, membrane potential regulation, and intracellular distribution, along with oxidative stress and neuron-specific aspects like memory and neurofibrillary tangles. This suggests a cohesive module coordinating cytoskeletal transport with mitochondrial function in neurons, with potential links to neurodegenerative processes.","confidence":"High","size":12,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031116","count":5},{"id":"GO:0090258","count":4},{"id":"GO:0001578","count":4},{"id":"GO:0032930","count":4},{"id":"GO:1905689","count":4}]},{"hash":"265984864309444523","title":"Unknown","description":"The top GO terms cover very disparate biological contexts: teichoic acid biosynthesis (bacterial cell wall), DNA repair, adipogenesis regulation, mRNA decay and deadenylation, stem cell/homeostasis and root development, mitotic chromosome alignment and microtubule dynamics, and signaling. This mix lacks a single coherent function or pathway tying the proteins together, indicating no obvious shared molecular role for the cluster.","confidence":"","size":12,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019350","count":2},{"id":"GO:0006284","count":2},{"id":"GO:0045600","count":2},{"id":"GO:0061014","count":2},{"id":"GO:0000289","count":2}]},{"hash":"7418908573311004","title":"Ubiquitin-Driven Quality Control and Mitophagy","description":"This cluster centers on ubiquitin-mediated quality control, including ERAD and deubiquitination, and links to mitochondrial quality control (mitophagy and regulation of mitochondrial fusion) and related cell fate events, with a few immune signaling terms that may reflect broader signaling cross-talk.","confidence":"Medium","size":12,"edges":50,"triangles":126,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0016579","count":3},{"id":"GO:0002223","count":2},{"id":"GO:0061060","count":2},{"id":"GO:0034389","count":2}]},{"hash":"1248577854003958738","title":"Unknown","description":"The terms span diverse processes from NF-kappaB signaling to development, metabolism, and cell cycle, with no clear single theme tying all proteins together. This lack of a cohesive functional cluster makes a specific, representative name inappropriate, so the label Unknown is used.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007252","count":3},{"id":"GO:0042345","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0055088","count":2}]},{"hash":"1575017826710590636","title":"Mitochondrial Translation and Stress Response","description":"This cluster is enriched for translation, especially mitochondrial translation, suggesting involvement in mitochondrial protein synthesis. The additional terms reflect stress and genome integrity signaling (cell cycle regulation, p53 pathway, ubiquitin pathways, actinomycin D response), indicating the proteins may coordinate mitochondrial translation with cellular stress responses.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0032543","count":2},{"id":"GO:1904667","count":1},{"id":"GO:0071158","count":1},{"id":"GO:0071157","count":1}]},{"hash":"467988921136289204","title":"Ribosome Biogenesis and RNA Processing","description":"This cluster is enriched for ribosome-related processes (translation, large subunit assembly and biogenesis) and RNA regulatory pathways (RISC assembly, primary miRNA processing, CRD-mediated mRNA stabilization), suggesting it groups proteins involved in ribosome biogenesis and RNA processing/regulation. A few terms such as dosage compensation and spinal cord morphogenesis appear peripheral or noisy, but do not override the dominant ribosome/RNA-processing theme.","confidence":"Medium","size":12,"edges":55,"triangles":139,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000027","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0045071","count":2},{"id":"GO:0009047","count":2}]},{"hash":"679694827532168146","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0042619","count":6},{"id":"GO:0009718","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0097171","count":4}]},{"hash":"651169173626862114","title":"Cell division machinery and septin dynamics","description":"The top GO terms cluster around chromosome cohesion in meiosis, mitotic spindle orientation, and septin ring organization/disassembly, plus related processes like bud neck septin ring formation and P granule assembly. These point to a shared theme of cell division and cytoskeletal organization, with regulation by protein dephosphorylation and signaling. The presence of a few outlier terms and a low edge count suggests a loose grouping, so the label is a cautious but focused interpretation. ","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":3},{"id":"GO:0006470","count":2},{"id":"GO:0051388","count":2},{"id":"GO:0090005","count":2},{"id":"GO:0031578","count":2}]},{"hash":"1336951785338781045","title":"Epigenetic Chromatin Regulation and Transcription Control","description":"This cluster converges on chromatin-level regulation and transcriptional control, as shown by histone acetylation, heterochromatin formation, negative regulation of transcription, and nucleus organization terms. Some terms touch on development or signaling (Rho pathway, cardiac morphogenesis, pro-B cell differentiation), but the overarching theme is epigenetic regulation of gene expression and chromatin structure.","confidence":"High","size":12,"edges":18,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0030466","count":5},{"id":"GO:0035023","count":4},{"id":"GO:0003209","count":4}]},{"hash":"1001211960484703802","title":"Neural development and cell adhesion","description":"GO terms are heavily skewed toward neural development and cell-cell adhesion (heterophilic/homophilic adhesion, synapse assembly, nervous system development, paranodal junctions), indicating a cluster centered on neuron connectivity and tissue organization. Less consistent terms related to bone formation and host cell interaction suggest some heterogeneity, but the neural adhesion theme is dominant.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":8},{"id":"GO:0007156","count":8},{"id":"GO:0051965","count":7},{"id":"GO:0007399","count":6},{"id":"GO:0043931","count":6}]},{"hash":"121254068327527703","title":"Pyrimidine Nucleotide Salvage","description":"Dominant GO terms describe salvage and metabolism of pyrimidine nucleotides (CMP, UMP, CTP, uracil salvage and pyrimidine nucleobase metabolic process), indicating a core theme of nucleotide recycling. While there are also broader terms like DNA-templated transcription and neurotransmitter secretion, the nucleotide salvage signals are the strongest common thread.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0044211","count":2},{"id":"GO:0044206","count":2},{"id":"GO:0006238","count":2}]},{"hash":"233085892578214675","title":"Steroid/Retinoid and Lipid Biosynthesis","description":"This cluster is dominated by GO terms tied to lipid and lipid-derived metabolite biosynthesis, including sphingolipid biosynthesis, retinoic acid and retinal biosynthesis, C21-steroid hormone metabolism, and estrogen biosynthesis, plus poly-hydroxybutyrate biosynthesis. While an antibiotic response term appears, the strongest signal is lipid/steroid/retinoid metabolic pathways, suggesting proteins function together in lipid metabolism and signaling. ","confidence":"Medium","size":12,"edges":16,"triangles":5,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0046677","count":8},{"id":"GO:0042619","count":8},{"id":"GO:0042574","count":7},{"id":"GO:0008207","count":7}]},{"hash":"2227100596494387979","title":"Coagulation and Complement Activation in Vasculature","description":"The cluster is dominated by GO terms for complement activation (classical and lectin pathways) and blood coagulation, along with endothelial barrier establishment and cell adhesion\u2014features typical of vascular immune-coagulation processes. Other terms (transcriptional regulation, synapse assembly, oxidant detoxification) are less central but may reflect multifunctional proteins present in this set.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0007157","count":5},{"id":"GO:1903142","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0000122","count":5}]},{"hash":"1348738803849563334","title":"Vertebrate embryonic development and sensory organ morphogenesis","description":"The top GO terms point to broad developmental processes across tissues, with strong emphasis on neural patterning (rhombomere 5 development, brain segmentation), sensory organ formation (retina development, inner ear morphogenesis/development), and additional organ/ skeletal development (pituitary gland development, osteoblast/chondrocyte differentiation), indicating a cohesive theme of vertebrate embryonic development and sensory organ morphogenesis.","confidence":"High","size":12,"edges":41,"triangles":66,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":7},{"id":"GO:0060041","count":7},{"id":"GO:0002076","count":7},{"id":"GO:0002087","count":7},{"id":"GO:0042472","count":6}]},{"hash":"1317719525091398490","title":"Embryonic tissue differentiation and neural fate specification","description":"The Top Terms show broad developmental differentiation across multiple tissues, with a strong emphasis on neural lineage specification (subpallium, spinal cord neurons, GABAergic interneurons) alongside other organ differentiation (pancreas, bronchiole, skeletal muscle, heart valve). This pattern fits a label centered on embryonic tissue differentiation with a neural emphasis, though the terms also cover non-neural tissues.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":12},{"id":"GO:0060163","count":11},{"id":"GO:0006366","count":11},{"id":"GO:0060435","count":11},{"id":"GO:0021520","count":11}]},{"hash":"1533101208461716646","title":"Oxidative stress-induced autophagy and apoptosis","description":"The cluster is enriched for oxidative stress response (hydrogen peroxide, metal ions), autophagy processes (reticulophagy, piecemeal microautophagy of the nucleus), and ubiquitin-related regulation (deubiquitination), along with apoptotic signaling and amino acid starvation response. This points to a cohesive theme of cellular stress management through autophagy and programmed cell death, with protein quality control as a supporting mechanism. The mucus secretion term appears less central to this core theme.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":5},{"id":"GO:0070301","count":5},{"id":"GO:0010040","count":5},{"id":"GO:0070257","count":5},{"id":"GO:0034629","count":5}]},{"hash":"1295020488892258320","title":"Unknown","description":"The top GO terms span very disparate processes (photosynthetic nonphotochemical quenching; GTPase regulation; pain sensing; neural development; immune cell differentiation; muscle and kidney development; memory T cell regulation). Because there is no clear, cohesive functional theme tying these proteins together, a single interpretable label cannot be assigned beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010196","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0050966","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0042092","count":3}]},{"hash":"1574693549599382244","title":"Translational initiation and proteolysis regulation","description":"Top terms cluster initiation of translation (preinitiation complex formation, IRES-dependent initiation, regulation of translational initiation) and proteolysis/ubiquitin-proteasome\u2013related protein catabolic processes, suggesting a shared theme of coordinating protein synthesis with degradation. Some germ cell terms appear sporadically but do not define the cluster\u2019s core function.","confidence":"Medium","size":12,"edges":34,"triangles":44,"max_degree":10,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0000338","count":3},{"id":"GO:0048140","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3}]},{"hash":"326681759613519949","title":"RNA processing and translation initiation","description":"This cluster centers on RNA processing and translation initiation, with many terms linked to spliceosome activity, mRNA modification and stabilization, and assembly of translation initiation complexes (preinitiation and eIF4F). The consistent theme across terms supports a function in mRNA maturation and initiation of translation.","confidence":"High","size":12,"edges":29,"triangles":29,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":9},{"id":"GO:0016556","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0097010","count":8},{"id":"GO:1902625","count":8}]},{"hash":"1641453875690226665","title":"Unknown","description":"The top terms span diverse, seemingly unrelated cellular processes (translation initiation, regulation of GTPase activity, cell division, sporulation, various transport and pH-related activities, and sensory processes), with no single dominant function tying the proteins together. This lack of a coherent shared theme makes it inappropriate to assign a concise, representative label beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000920","count":3},{"id":"GO:0006355","count":2}]},{"hash":"517845322743197438","title":"Neural development and sensory perception cluster","description":"Dominant terms center on nervous system development and sensory perception (vision, pain) with supporting roles for ion transport and transcriptional regulation, suggesting a cluster focused on neural development and sensory signaling; some annotations (dsRNA response, sperm capacitation) are outliers.","confidence":"Medium","size":12,"edges":15,"triangles":3,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043330","count":7},{"id":"GO:0071333","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0046827","count":7}]},{"hash":"1116564181208291068","title":"Ribosome biogenesis and mitochondrial dynamics","description":"The terms include ribosome-related processes (rRNA processing, translational termination, selenocysteine incorporation, protein localization to nucleolus) and mitochondrial dynamics (mitochondrion inheritance, intracellular distribution of mitochondria, mitochondrial fission), suggesting two dominant themes within the cluster. Since there isn\u2019t a single unifying function for all members, the name captures the two key axes of activity observed in the GO terms.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":2},{"id":"GO:0090502","count":2},{"id":"GO:0045792","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0006415","count":2}]},{"hash":"2061321898121417617","title":"Dopaminergic and adrenergic neural signaling","description":"The cluster centers on neural signaling with autonomic modulation: dopaminergic synaptic transmission, MAPK-activated adrenergic receptor signaling, and heart-rate regulation by adrenaline. Supporting terms include prepulse inhibition and regulation of glutamatergic transmission, with peripheral processes such as xenobiotic response, diet-induced thermogenesis, and enteric smooth muscle differentiation, suggesting a broad but neuron\u2013autonomic-aligned function.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":8},{"id":"GO:0071883","count":7},{"id":"GO:0001996","count":7},{"id":"GO:0048609","count":7},{"id":"GO:0051967","count":7}]},{"hash":"1309646504418589859","title":"Unknown","description":"The top GO terms are broad and inconsistent, with a few temperature-related terms (cellular response to temperature stimulus, response to cold, diet-induced thermogenesis) but also many unrelated terms (skin development, cerebellum maturation, flagellated sperm motility, endothelial delamination). The network connectivity is minimal (one edge), suggesting no cohesive functional theme. Therefore, there is no clear shared function to name; label Unknown with None.","confidence":"","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0071502","count":5}]},{"hash":"1780352187907625160","title":"Cytoskeleton remodeling and membrane trafficking","description":"Based on the top GO terms, the proteins cluster around actin-based protrusions (filopodium and lamellipodium assembly) and Rac signaling, together with membrane trafficking (Golgi to plasma membrane transport) and lipid homeostasis, plus mitochondrial fission. This points to a cohesive theme of cytoskeleton remodeling coupled with membrane dynamics and trafficking, with some inclusion of membrane signaling components such as GABAergic transmission. Therefore, the core label captures the shared function of cytoskeleton-membrane coordination driving cell surface structure and movement.","confidence":"High","size":12,"edges":18,"triangles":10,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":10},{"id":"GO:0010628","count":10},{"id":"GO:0045792","count":9},{"id":"GO:0016601","count":8},{"id":"GO:0010592","count":8}]},{"hash":"182417175290335503","title":"Neurodevelopment and Sensory Organ Formation","description":"The cluster is dominated by terms related to nervous system and sensory organ development, including brain development, inner ear development, retina development, neural tube closure, and sensory perception of sound, plus related processes like synapse assembly. These collectively indicate a cohesive theme of neural and sensory organ formation and maturation, with a few broader embryonic morphogenesis terms that reflect general development context. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0098911","count":3}]},{"hash":"2116765034280934712","title":"Hematopoietic lineage differentiation","description":"The set of GO terms centers on differentiation of immune and blood lineages (macrophage, granulocyte, dendritic cell, erythrocyte, and lymphoid progenitors). It also includes regulatory processes (negative regulation of RNA Pol II transcription and miRNA transcription) typical of differentiation programs. Some terms (primitive streak formation, endocardial cushion development) reflect broader developmental contexts, but the dominant theme is hematopoietic immune cell differentiation.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030225","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0045648","count":4},{"id":"GO:0030851","count":4},{"id":"GO:0043011","count":3}]},{"hash":"1945828595654861454","title":"Neural development and vesicle exocytosis","description":"These proteins cluster around nervous system and brain development terms and strongly feature vesicle fusion with calcium-dependent exocytosis and Rho/GTPase signaling, suggesting a module coordinating neural development with regulated secretion. Some terms (pseudohyphal growth, abscisic acid signaling) appear as cross-species outliers and do not define the core function.","confidence":"High","size":12,"edges":61,"triangles":177,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":11},{"id":"GO:0001302","count":11},{"id":"GO:0006906","count":11},{"id":"GO:0045956","count":11},{"id":"GO:0001501","count":11}]},{"hash":"1559324060629911725","title":"Ciliogenesis and Hedgehog-driven organ development","description":"This cluster centers on cilium assembly and Hedgehog signaling (Smoothened pathway), with supporting developmental terms such as kidney and heart development and intramembranous ossification. Endocytosis and cytoskeletal regulation terms further align with ciliary trafficking and structure, suggesting these proteins collectively participate in ciliogenesis linked to organ development and Hedgehog pathway activity.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0001822","count":3},{"id":"GO:0031532","count":3},{"id":"GO:2000785","count":2},{"id":"GO:0007224","count":2}]},{"hash":"1579945686264141159","title":"GPCR-cAMP Signaling in Retina and Heart Development","description":"Top GO terms point to GPCR-mediated signaling pathways (dopamine and adrenergic receptor signaling) activating adenylate cyclase and PLC, along with cAMP signaling. Presence of retina development and phototransduction, plus heart development, suggests a role in eye/retina maturation and cardiac development, with additional links to general cell proliferation and GTPase regulation. This combination supports a GPCR-driven signaling cluster impacting retina and heart development.","confidence":"High","size":12,"edges":50,"triangles":100,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":12},{"id":"GO:0060041","count":10},{"id":"GO:0008284","count":10},{"id":"GO:0008283","count":10},{"id":"GO:0071880","count":8}]},{"hash":"1161401352317200415","title":"Antiviral Innate Immune Response","description":"This cluster\u2019s top GO terms center on innate immune defense against viruses and interferon signaling (innate immune response, defense response to virus, cellular response to interferon-alpha), with additional linkage to oxidative stress (cellular response to hydrogen peroxide). While some included terms are obsolete or peripheral, the dominant pattern reflects antiviral innate immunity and IFN-driven responses.","confidence":"High","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0035457","count":2},{"id":"GO:0070301","count":2},{"id":"GO:2001162","count":2}]},{"hash":"683917160279221668","title":"Unknown","description":"The top GO terms span very diverse processes (RNA splicing, GTPase regulation, aging, skin development, protein oligomerization, pinocytosis, apoptosis, and specific developmental regulation) with no single cohesive function tying the proteins together, and with no edges connecting members; thus a specific, representative label cannot be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0051260","count":4}]},{"hash":"289399315122483841","title":"Neuronal and adrenergic signaling under temperature stress","description":"This cluster centers on neuronal communication (dopaminergic and glutamatergic synaptic transmission, membrane potential regulation) and autonomic regulation (adrenergic receptor signaling and heart rate control), with temperature-related GO terms (diet-induced thermogenesis and cellular response to temperature stimulus). Together, these terms suggest a common theme of neural and autonomic signaling modulated by temperature stress. Some terms like reproductive process and xenobiotic response appear peripheral noise relative to the dominant signaling theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0042391","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0001963","count":2}]},{"hash":"624191585643650677","title":"Mucosal Immunoglobulin Transport and Immune Signaling","description":"The top GO terms are dominated by immunological activities: immunoglobulin production, immunoglobulin transcytosis via the polymeric immunoglobulin receptor (PIGR), T cell activation regulation, CCR7 signaling, NK cell\u2013mediated cytotoxicity, and peptidoglycan detection. This points to a cohesive function centered on immune surveillance and antibody transport at epithelial/mucosal interfaces, with GI epithelium maintenance supporting barrier immunity. Some terms (paranodal junction assembly and AV node adhesion) may reflect shared Ig-superfamily domains involved in cell adhesion and tissue communication, linking immune signaling with epithelial/nerve interfaces. Overall, the cluster appears to group proteins involved in mucosal immunity, antibody transport, and immune cell signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002377","count":5},{"id":"GO:0050910","count":4},{"id":"GO:0030913","count":4},{"id":"GO:0030277","count":4},{"id":"GO:2001189","count":4}]},{"hash":"1894506774125150375","title":"Mitochondrial metabolite transport and apoptosis regulation","description":"The terms cluster around mitochondrial transport (ADP, nucleotides, CoA, iron, pyrimidine nucleotides), along with regulation of mitochondrial membrane potential and apoptotic/necroptotic processes. An outlier term like female pregnancy is unlikely to reflect the core function, but the dominant theme points to mitochondria-related transport and cell death regulation, justifying this label. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":12},{"id":"GO:0030302","count":11},{"id":"GO:0051881","count":11},{"id":"GO:0015866","count":11},{"id":"GO:0008637","count":11}]},{"hash":"168487049083707652","title":"Mitochondrial energy metabolism and apoptosis regulation","description":"The dominant GO terms point to mitochondrial energy pathways (fatty acid beta-oxidation, ketone body and amino acid catabolism) and cellular stress responses (response to starvation), plus a clear link to mitochondrial apoptosis regulation via outer membrane permeabilization. While a few terms (e.g., antibiotic biosynthesis, brain development) are less central and may reflect annotation noise or broader tissue roles, the clear cluster of metabolic and mitochondrial apoptotic terms supports this naming as representative of the group. ","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006635","count":7},{"id":"GO:0017000","count":6},{"id":"GO:0051260","count":4},{"id":"GO:0019619","count":4},{"id":"GO:1901029","count":4}]},{"hash":"1839547153558891411","title":"RNA processing and translation initiation","description":"These proteins map to translation initiation (preinitiation complex formation, eIF4F assembly, translation reinitiation) and RNA processing (mRNA splicing, modification, and stabilization), suggesting a role in post-transcriptional gene expression regulation.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":6},{"id":"GO:0002188","count":6},{"id":"GO:1901407","count":5},{"id":"GO:0016556","count":4},{"id":"GO:0097010","count":4}]},{"hash":"896435732775605457","title":"Embryonic development and organ morphogenesis","description":"The proteins show enrichment for embryogenesis and tissue morphogenesis across multiple organs (heart, ovary, prostate, eye), along with differentiation processes and estrogen-responsive regulation, indicating a general developmental program guiding organ formation and tissue differentiation.","confidence":"Medium","size":11,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060528","count":5},{"id":"GO:0001547","count":5},{"id":"GO:0055010","count":5},{"id":"GO:0060038","count":5},{"id":"GO:0001701","count":5}]},{"hash":"2256136699893421158","title":"Mitotic division and cytoskeleton dynamics","description":"This cluster is dominated by mitosis- and cell cycle-related terms (cell division, mitotic cell cycle, sister chromatid segregation, CENP-A chromatin assembly) and cytoskeletal remodeling via Arp2/3-mediated actin nucleation, suggesting a cohesive theme around cell division coupled with cytoskeletal changes; additional terms for ribosome biogenesis, transcription, and ER-Golgi transport reflect supportive cellular growth processes during division.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0000747","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0031175","count":4}]},{"hash":"169951747115490432","title":"Prokaryotic energy metabolism and flagellar motility","description":"Top terms indicate strong emphasis on bacterial flagellum assembly and flagellum-dependent motility, pointing to a motility-related function. Concurrently, several terms describe energy-generating pathways (electron transport chain, oxidation-reduction processes, formate/lactate oxidation, photosynthesis, methanogenesis), suggesting a linkage between motility apparatus and prokaryotic energy metabolism. Some housekeeping processes like tRNA processing and beta-alanine biosynthesis are present but less defining. Overall, the cluster seems to group proteins involved in prokaryotic motility coupled with energy production pathways.","confidence":"Medium","size":11,"edges":52,"triangles":139,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0044780","count":2},{"id":"GO:0019684","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0015948","count":2},{"id":"GO:0022900","count":2}]},{"hash":"2152206803647066021","title":"Amino acid and nucleotide biosynthesis","description":"This cluster centers on core metabolic biosynthetic processes, including amino acid synthesis (glutamine and arginine; methionine in older annotation) and nucleotide biosynthesis (GMP, NAD+), along with associated metabolic activities like carbohydrate phosphorylation. Sporulation and tRNA modification terms appear but are ancillary to the dominant biosynthetic theme.","confidence":"Medium","size":11,"edges":8,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":3},{"id":"GO:0046835","count":3},{"id":"GO:0009086","count":2},{"id":"GO:0006177","count":2},{"id":"GO:0009435","count":2}]},{"hash":"1761335847870720812","title":"DNA repair and oxidative stress response","description":"This cluster is enriched for base-excision repair and DNA recombination terms, plus responses to xenobiotics and hydrogen peroxide, pointing to DNA damage repair and redox stress management. Additional terms on mRNA stability regulation and metabolic signaling (hormone response, glycogen regulation) suggest a broader stress-response network that links genome maintenance with cellular signaling and metabolism.","confidence":"Medium","size":11,"edges":49,"triangles":119,"max_degree":10,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":10},{"id":"GO:0042493","count":9},{"id":"GO:0007568","count":9},{"id":"GO:0006310","count":7},{"id":"GO:0045454","count":6}]},{"hash":"1766747822520259289","title":"Cardiac morphogenesis and calcium signaling","description":"The top GO terms are dominated by heart-related processes: Purkinje cell signaling to ventricular muscle, regulation of atrial action potential, outflow tract morphogenesis, and calcium release from the sarcoplasmic reticulum, all pointing to cardiac development and electrophysiology. While there are some general terms (multicellular development, ossification, mitotic cycle) present, the strongest and recurring theme centers on cardiac morphogenesis and calcium-mediated signaling essential for heart muscle function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0007269","count":5},{"id":"GO:0007613","count":5}]},{"hash":"137860242649477973","title":"Receptor signaling and actin remodeling","description":"The GO terms point to membrane receptor\u2013mediated signaling (EGFR, ephrin, T cell receptor) together with cytoskeletal dynamics (filopodium, podosome formation, actin branching), plus developmental contexts. This suggests proteins coordinating signal transduction with actin remodeling across development and immune contexts.","confidence":"High","size":11,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010801","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0090263","count":3}]},{"hash":"1489273031607685601","title":"Diverse Transmembrane Transporters","description":"These proteins are collectively enriched for transmembrane transport activities across a range of substrates (ions like K+, Na+, phosphate, nitrite; sugars like arabinose and galactose; and other small molecules such as sialic acid and 4-hydroxyphenylacetate), with an additional note on neurotransmitter loading into synaptic vesicles. This pattern points to a broad membrane transport role rather than a single substrate pathway, justifying a label that emphasizes diverse transporter activity.","confidence":"High","size":11,"edges":13,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":9},{"id":"GO:1900754","count":8},{"id":"GO:0098700","count":8},{"id":"GO:0015739","count":8},{"id":"GO:0042891","count":8}]},{"hash":"2277910451175421877","title":"Lipid and steroid metabolism","description":"The top GO terms cluster around lipid and steroid-related metabolism (triglyceride, bile acid, progesterone, retinoic acid, and ecdysone processes), suggesting a cohesive theme of lipid/steroid biosynthesis and transformation. Supporting terms like macrolide biosynthesis and various environmental responses appear as peripheral signals, but the dominant pattern is metabolism of lipids and steroid hormones, justifying this label.","confidence":"Medium","size":11,"edges":30,"triangles":35,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006641","count":10},{"id":"GO:0033068","count":7},{"id":"GO:0006697","count":7},{"id":"GO:0042448","count":7},{"id":"GO:0010193","count":7}]},{"hash":"325683874810226342","title":"Neural and hematopoietic signaling pathways","description":"This cluster's GO terms point to multiple receptor-mediated signaling pathways (Wnt, TRK/RTK, PDGF/KIT, NF-kappaB/JNK) with neural development (cerebellar cortex formation, neurotrophin signaling) and immune/hematopoietic activity (IL-7 response, IL-3 production, hemopoiesis). The unifying theme is diverse signaling modules active in neural and blood-immune contexts, justifying a label around broad signaling pathways.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090263","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0048011","count":5},{"id":"GO:0021697","count":5},{"id":"GO:0007257","count":5}]},{"hash":"907858889042284513","title":"Unknown","description":"The 11 proteins are linked to a wide range of disparate processes (neural signaling, DNA repair, immune signaling, development, cell-cycle/kinetochore functions, and stress responses), with no single dominant function uniting them, so a concise, representative label cannot be determined.","confidence":"","size":11,"edges":21,"triangles":13,"max_degree":7,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0001963","count":11},{"id":"GO:0006281","count":11},{"id":"GO:0045071","count":11},{"id":"GO:0032801","count":11},{"id":"GO:0034501","count":11}]},{"hash":"2270789594286325897","title":"RNA processing and miRNA regulation","description":"The set is dominated by post-transcriptional RNA metabolism: mRNA splicing, mRNA stability and decay, and miRNA-mediated regulation of gene expression. These processes form a coherent theme of RNA processing and post-transcriptional control, suggesting a module focused on RNA handling rather than transcriptional regulation; a few obsolete terms are present but do not change the core signal. ","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0000398","count":6},{"id":"GO:1901254","count":6},{"id":"GO:0033129","count":6},{"id":"GO:2000637","count":6}]},{"hash":"1458184561807432955","title":"FGFR-MAPK signaling in organ branching morphogenesis","description":"GO terms cluster around organ development and branching morphogenesis, notably FGFR-regulated MAPK/ERK pathways (ERK1/2, MAPKKK) and salivary gland branching with mesenchymal-epithelial signaling, suggesting a cohesive role in FGFR-MAPK\u2013driven developmental morphogenesis across tissues.","confidence":"High","size":11,"edges":16,"triangles":4,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001525","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0007399","count":7},{"id":"GO:0060484","count":7},{"id":"GO:0007275","count":7}]},{"hash":"767100161975758761","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":15,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":5},{"id":"GO:0060059","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0060661","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1848159920649796374","title":"Muscle development and stress signaling","description":"This cluster centers on muscle-related development (positive regulation of myoblast fusion, integrin activation, locomotory behavior) and stress-responsive pathways (cellular response to dexamethasone, arsenic exposure, necroptosis, antiviral signaling), with growth/protein synthesis signals from PI3K/AKT and ribosome biogenesis. The combination suggests a coherent theme of muscle differentiation coordinated with stress and survival signaling, making the label representative of the cluster\u2019s function.","confidence":"Medium","size":11,"edges":31,"triangles":40,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071549","count":2},{"id":"GO:0046685","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0070266","count":2}]},{"hash":"2017121101598727444","title":"Lineage Differentiation and Transcriptional Regulation","description":"The set spans differentiation programs across lineages (vitellogenesis; granulocyte and erythrocyte differentiation) and includes regulation of transcription and chromatin state (negative regulation of RNAP II transcription; histone H3-K4 demethylation), with accompanying metabolic/contextual signals (glycolysis; response to starvation/food). This suggests a cohesive theme of lineage specification governed by transcriptional and epigenetic control, with metabolic responsiveness. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007296","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0034720","count":3},{"id":"GO:0030851","count":3},{"id":"GO:0045648","count":3}]},{"hash":"1791892144771718351","title":"Neural development and cell-adhesion signaling","description":"Top GO terms are dominated by nervous system development and synapse-related processes, with both heterophilic and homophilic cell-cell adhesion terms and integrin activation signaling pointing to CAM-driven adhesion events coordinating neural tissue morphogenesis. While some terms touch bone maturation and cardiac regulation, the prevailing pattern is neural development intertwined with adhesion-mediated signaling, supporting a label focused on neural development and cell adhesion.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0043931","count":10},{"id":"GO:0007156","count":10},{"id":"GO:0051965","count":9}]},{"hash":"1689566407733263850","title":"Unknown","description":"The top GO terms span diverse, seemingly unrelated processes (B cell chemotaxis, pigmentation, postsynaptic/presynaptic membrane organization, various developmental pathways, and PI3K/AKT signaling regulation), with several obsolete terms and no evident common function. Edges and connectivity are zero, offering no cohesive theme. Therefore, there isn\u2019t a clear, representative label for this cluster.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:1902987","count":2},{"id":"GO:0035754","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0097104","count":2}]},{"hash":"766019340190689516","title":"Neural development and cardiac differentiation","description":"This cluster is dominated by neural development terms (neuron migration, axonogenesis, Purkinje cell differentiation) and cardiac muscle differentiation (atrial cardiomyocytes, cardiac myoblast regulation), with supporting terms for cell-matrix adhesion and developmental processes. While there are a few outliers (platelet aggregation, paramesonephric duct development), the strongest signal ties neural differentiation and heart muscle development together as a shared developmental theme.","confidence":"Medium","size":11,"edges":6,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0097477","count":7},{"id":"GO:0007160","count":7},{"id":"GO:0070527","count":7},{"id":"GO:0061205","count":6},{"id":"GO:0055011","count":6}]},{"hash":"760784306001363057","title":"Epithelial morphogenesis and cell adhesion","description":"The terms cluster around morphogenesis and polarity of epithelial tissues (hair follicles, salivary glands, podocytes, embryonic epithelium), including branching, planar polarity, and various forms of cell\u2013cell adhesion, indicating a cohesive role in epithelial development and intercellular interactions.","confidence":"High","size":11,"edges":53,"triangles":148,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048677","count":11},{"id":"GO:0042249","count":11},{"id":"GO:0060445","count":11},{"id":"GO:0030334","count":11},{"id":"GO:0072274","count":11}]},{"hash":"1929527871909033172","title":"Vertebrate Embryonic Development","description":"The top GO terms point to multiple embryonic development processes across tissues (pituitary gland, rhombomere, somite, atrial cardiomyocyte differentiation, neural fate), indicating a cluster of proteins involved in vertebrate embryogenesis and early organogenesis. Some terms also include transcription regulation, consistent with developmental control.","confidence":"Medium","size":11,"edges":18,"triangles":12,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":7},{"id":"GO:0000122","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0061205","count":4},{"id":"GO:0021570","count":4}]},{"hash":"1302920514538153853","title":"Neural cell adhesion and signaling","description":"The top GO terms are dominated by cell-cell adhesion (homophilic and heterophilic) and transmission of nerve impulse, with integrin-mediated signaling supporting adhesion and signaling processes. This points to a cluster enriched for neuronal adhesion molecules and related signaling pathways, aligning best with a neural cell adhesion and signaling theme; the other terms appear less representative noise. ","confidence":"High","size":11,"edges":39,"triangles":63,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0019226","count":2},{"id":"GO:0016337","count":2},{"id":"GO:0007156","count":2}]},{"hash":"2071299219065301592","title":"ER Protein Folding Under Heat Stress","description":"This cluster is enriched for terms related to chaperone-assisted refolding, protein folding in the endoplasmic reticulum, ER targeting/translocation, and responses to heat, along with redox homeostasis. Together these point to a group of proteins that cooperate in the secretory pathway to properly fold and manage misfolded proteins during heat stress, with some outliers (e.g., DNA replication, parathyroid hormone responses) likely reflecting broader cellular roles or annotation noise.","confidence":"High","size":11,"edges":14,"triangles":8,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":7},{"id":"GO:0090084","count":7},{"id":"GO:0031204","count":7},{"id":"GO:1900035","count":7},{"id":"GO:0006260","count":7}]},{"hash":"582463812566134057","title":"Neurodevelopment and Tissue Morphogenesis","description":"The top GO terms cluster around brain development, neuronal stem cell maintenance, and broad multicellular development, together with cell adhesion and tissue morphogenesis (cadherin-mediated adhesion, apical protein localization, blood vessel maturation, skeletal system morphogenesis). These imply a set of proteins involved in neural development and morphogenesis across tissues, with a few peripheral terms likely representing noise (e.g., B cell differentiation, centromere assembly). Thus the label reflects the core theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0045176","count":3},{"id":"GO:0097150","count":3}]},{"hash":"456678496795712147","title":"Telomere Maintenance & DNA Damage Response","description":"The top terms center on telomere dynamics (meiotic telomere clustering, telomere maintenance via recombination) and chromatin/repair processes (heterochromatin maintenance, error-free translesion synthesis), with ubiquitin-related regulation (K48/K6-linked ubiquitination) and neddylation pointing to protein turnover and signaling in DNA damage response. Neuron-related terms appear less directly relevant, likely offshoot effects. Overall, the cluster reflects telomere maintenance and DNA damage response pathways.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0045141","count":11},{"id":"GO:0051092","count":11},{"id":"GO:0010976","count":11},{"id":"GO:0043524","count":11},{"id":"GO:0045116","count":11}]},{"hash":"1156768324360987366","title":"Hormone biosynthesis and metabolism","description":"This cluster is dominated by GO terms for the production and breakdown of hormone- and lipid-derived signaling molecules, including ecdysone biosynthesis, progesterone metabolic process, retinoic acid catabolic process, and bile acid biosynthesis, suggesting a cohesive theme around hormone and lipid metabolism. Some terms like macrolide biosynthetic process are broader biosynthesis annotations, and a few environmental response terms appear as secondary signals, but the core pattern points to hormonal biosynthesis/metabolism.","confidence":"Medium","size":11,"edges":9,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0033068","count":11},{"id":"GO:0006697","count":11},{"id":"GO:0042448","count":11},{"id":"GO:0010193","count":11},{"id":"GO:0071615","count":11}]},{"hash":"1007042119868496782","title":"Proteostasis and ubiquitination","description":"The top GO terms cluster around protein quality control and turnover: ubiquitination and ubiquitin recycling, cellular response to misfolded proteins, and aggresome assembly, which together define proteostasis. Supporting terms like N-linked glycosylation and protein oligomerization also relate to protein maturation and assembly, reinforcing a theme of managing and processing proteins within the cell.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0060999","count":2},{"id":"GO:0007264","count":2}]},{"hash":"1035400523081656875","title":"mRNA processing and translation initiation","description":"The top GO terms emphasize mRNA maturation steps (polyadenylation, splicing, stabilization) and assembly of translation initiation machinery (preinitiation complex, eIF4F complex). Together, they point to a cohesive set of proteins involved in RNA processing and the initiation of protein synthesis, supporting a label centered on mRNA processing and translation initiation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0016556","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0097010","count":3},{"id":"GO:1902625","count":3}]},{"hash":"1464528979328034770","title":"Thermal and sensory stress response pathways","description":"The Top Terms cluster around responses to temperature and sensory stimuli (temperature stimulus, diet-induced thermogenesis, circadian regulation, startle and pain perception) and ion transport processes (calcium and potassium), suggesting a cohesive theme of thermal/sensory stress signaling and related muscle/neuronal responses in a multicellular organism.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0002024","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0045188","count":3},{"id":"GO:0001964","count":3}]},{"hash":"1286772145587599477","title":"Embryonic neuroendocrine development","description":"The top GO terms converge on development of neural and endocrine tissues (pituitary and thyroid glands, peripheral nervous system neurons) and early embryogenesis (primitive streak formation) with transcriptional regulation, pointing to a cohesive theme of embryonic neural-endocrine differentiation and gene expression control.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":7},{"id":"GO:0048935","count":6},{"id":"GO:0090009","count":6},{"id":"GO:0000122","count":6},{"id":"GO:2000288","count":6}]},{"hash":"467002405534767144","title":"Craniofacial and odontogenic development","description":"This cluster\u2019s terms heavily emphasize craniofacial morphogenesis (roof of mouth, cartilage development), tooth formation (odontogenesis), and related embryonic patterning (telencephalon regionalization, primitive streak formation), with additional notes on broader organogenesis and transcriptional regulation. The common thread is embryonic development across multiple tissues, guided by transcriptional programs rather than a single pathway, making the label Craniofacial and odontogenic development a representative shorthand.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0051216","count":5},{"id":"GO:0006355","count":4},{"id":"GO:0003323","count":4}]},{"hash":"842032121810097399","title":"Ion Transport and Membrane Excitability","description":"This cluster centers on electrical excitability and ion homeostasis, highlighted by membrane potential regulation, action potential dynamics, skeletal/cardiac muscle signaling, and potassium ion transport. While there are some outliers related to development and pigment granules, the dominant theme ties to how cells generate and regulate electrical signals. ","confidence":"Medium","size":11,"edges":40,"triangles":74,"max_degree":10,"top_function":"nervous system process","top_go_terms":[{"id":"GO:0098914","count":10},{"id":"GO:0060075","count":10},{"id":"GO:0035220","count":9},{"id":"GO:0014861","count":9},{"id":"GO:0022010","count":9}]},{"hash":"1877010907478205515","title":"Triglyceride catabolism and lipid remodeling","description":"The top GO terms are dominated by triglyceride-related processes (catabolism, mobilization, acyl-chain remodeling) and phospholipid catabolism (phosphatidylcholine and phosphatidylethanolamine), indicating a clear theme of triglyceride turnover and membrane lipid remodeling; other terms on integrin/Notch signaling and phagocytosis are less central to the core theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":3},{"id":"GO:0019433","count":3},{"id":"GO:0006910","count":2},{"id":"GO:0034638","count":2},{"id":"GO:2000480","count":2}]},{"hash":"1950448790049808952","title":"Neuronal signaling and addiction-related responses","description":"The top terms cluster around neural sensing (visual and pain), dopaminergic synaptic transmission, cocaine-related behavior, and MAPK/ERK pathway regulation. Together they suggest a neural signaling and drug-response theme, with MAPK signaling as a shared mechanism; ancillary terms like heart development and macrophage chemotaxis may reflect broader expression but are secondary to the neural/drug-response pattern.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":10},{"id":"GO:0070374","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0010759","count":10},{"id":"GO:0008542","count":10}]},{"hash":"883016960659343195","title":"Cell junctions and epithelial barrier formation","description":"Based on the top GO terms, the cluster is dominated by processes involving adherens and tight junction assembly, membrane localization to basolateral surfaces, and endothelial/epithelial barrier establishment, with regulation of Rho signaling supporting junctional dynamics. While one term references cerebellar development, this reflects tissue-specific adhesion and organization, which fits the overarching theme of cell\u2013cell junctions and polarity across tissues.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0070433","count":9},{"id":"GO:0032416","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0071896","count":8},{"id":"GO:0021694","count":8}]},{"hash":"1519486743571519298","title":"Dopaminergic neuron development and synaptic regulation","description":"The cluster shows strong enrichment for neural-focused terms: midbrain dopaminergic neuron differentiation, nervous system development, modification of synaptic structure, GPCR signaling, neuron maturation, and endocytosis, plus growth-related terms. This pattern points to a cohesive theme around neuronal development and synaptic signaling, particularly involving dopaminergic pathways, with supportive roles in general growth and organ development.","confidence":"High","size":11,"edges":52,"triangles":139,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0099563","count":11},{"id":"GO:0014041","count":11},{"id":"GO:0045792","count":11},{"id":"GO:0038027","count":11},{"id":"GO:0007186","count":11}]},{"hash":"1331944762811335071","title":"Ribosome Biogenesis and Translation","description":"The cluster centers on ribosome-related processes: ribosome biogenesis, export of ribosomal subunits, cytoplasmic translation, and tRNA modification. These are complemented by cell growth activities (cell cycle, cell division, and septum assembly), indicating coordination between ribosome production and cell proliferation. A minor term about salt-stress response is present but less defining for the cluster\u2019s core function.","confidence":"High","size":11,"edges":20,"triangles":2,"max_degree":7,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0000747","count":4},{"id":"GO:0002181","count":4},{"id":"GO:1901001","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0000055","count":4}]},{"hash":"753352148942068853","title":"Ubiquitin-Mediated Immune Regulation","description":"This cluster centers on ubiquitin-dependent processes (protein and histone ubiquitination) and immune signaling, spanning adaptive immunity (V(D)J recombination, adaptive immune response), antiviral regulation (RIG-I signaling), and T cell proliferation control, with links to NF-kappaB regulation and chromatin state. The GO terms collectively point to ubiquitin-driven modulation of immune pathways and chromatin dynamics.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0002250","count":5},{"id":"GO:0033151","count":4},{"id":"GO:0036205","count":4},{"id":"GO:0051092","count":4}]},{"hash":"2120389599010503734","title":"Dendritic cell\u2013driven immunity and angiogenesis","description":"This cluster shows strong enrichment for dendritic cell cytokine production, T cell activation regulation (CCR7 signaling), and endothelial chemotaxis via VEGF signaling, plus recognition of peptidoglycan, pointing to a shared theme of immune activation linked to vascular remodeling. While there are some developmental terms, the immune-vascular connection is the most coherent unifier.","confidence":"Medium","size":11,"edges":50,"triangles":124,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0045765","count":4},{"id":"GO:0019226","count":4},{"id":"GO:0030277","count":3},{"id":"GO:0060445","count":3},{"id":"GO:0048672","count":3}]},{"hash":"1986480370584539363","title":"Thermogenesis and hypoxic metabolic response","description":"This cluster is driven by terms tied to temperature and energy metabolism\u2014 notably response to hypoxia, response to cold, and diet-induced thermogenesis, along with brown fat differentiation regulation and calcium/potassium signaling. The dominant signals point to adipose tissue thermogenesis and metabolic adaptation under thermal and hypoxic stress, with a few outliers (cerebellum maturation, sperm motility) that are less connected but not contradictory. ","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":5},{"id":"GO:0021590","count":4},{"id":"GO:0009409","count":4},{"id":"GO:0030317","count":4},{"id":"GO:0097497","count":4}]},{"hash":"813713314741849057","title":"Unknown","description":"The top GO terms span fungal development, xenobiotic response, several immune-related processes (monocyte differentiation, neutrophil chemotaxis, T cell receptor signaling, TGF-beta stimulus), plus signaling and phototransduction terms and even nuclear transport regulation. The diversity suggests no single cohesive function or theme tying these proteins together, so there is no clear, representative label beyond Unknown.","confidence":"","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048837","count":5},{"id":"GO:0035690","count":5},{"id":"GO:0030224","count":5},{"id":"GO:0030593","count":5},{"id":"GO:0010753","count":5}]},{"hash":"612652907309257271","title":"Developmental Morphogenesis and Cell Migration","description":"This cluster is dominated by terms linked to dynamic cell movement and tissue formation, including filopodium assembly, cell spreading, cell migration, sprouting angiogenesis, and blood vessel development, along with ECM remodeling via hyaluronan metabolism. Amelogenesis and the acrosome reaction emphasize developmental differentiation in different tissues, while T cell activation and sensory perception of sound reflect lineage-specific differentiation contexts. The common thread is broad developmental morphogenesis with an emphasis on cell adhesion, movement, and tissue remodeling, making this a cohesive developmental/morphogenesis cluster despite some lineage-specific outliers.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":3},{"id":"GO:0030212","count":3},{"id":"GO:0002291","count":3},{"id":"GO:0034446","count":3},{"id":"GO:0002042","count":3}]},{"hash":"1704157795684558885","title":"Sympathetic Neurotransmission and Stress Response","description":"This cluster is dominated by terms for dopaminergic synaptic transmission, adrenergic MAPK signaling, and heart-rate regulation by epinephrine, pointing to autonomic and neuroendocrine control. Additional terms cover thermogenesis, enteric smooth muscle differentiation, and sensorimotor gating (prepulse inhibition), suggesting a cohesive theme of sympathetic regulation of neural signaling, metabolism, and gut function, with broader stress and immune-modulatory connections. Some terms (e.g., reproductive processes, TNF regulation, xenobiotic response) are broader but can be linked to systemic stress and neural-immune interactions, supporting a central autonomic/neuroendocrine focus.","confidence":"Medium","size":11,"edges":45,"triangles":95,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":11},{"id":"GO:0071883","count":11},{"id":"GO:0001996","count":11},{"id":"GO:0048609","count":11},{"id":"GO:0051967","count":11}]},{"hash":"2211959382793904148","title":"Neural control of autonomic physiology","description":"The top GO terms center on dopaminergic synaptic transmission, MAPK-activating adrenergic receptor signaling, and epinephrine/norepinephrine\u2013driven heart rate regulation, all pointing to neural and autonomic regulation. Additional terms reflect neuroendocrine/metabolic and gut\u2013brain\u2013muscle interactions (diet-induced thermogenesis, enteric smooth muscle differentiation, prepulse inhibition, reproduction, TNF regulation, xenobiotic responses), which fit a cohesive theme of neural control coordinating physiological processes. Confidence: High","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":11},{"id":"GO:0071883","count":11},{"id":"GO:0001996","count":11},{"id":"GO:0048609","count":11},{"id":"GO:0051967","count":11}]},{"hash":"1837361220086414627","title":"Plant meiosis and pollen development","description":"The top GO terms center on meiosis-related processes (reciprocal meiotic recombination, male meiosis I), cell cycle, and pollen development, with supporting DNA repair and heteroduplex formation terms, suggesting a cohesive cluster of proteins involved in plant meiosis and gametogenesis. While there are also tRNA modification and aminoacylation terms, these likely reflect shared cellular maintenance roles rather than redefining the main theme. Overall, the cluster appears best described by plant meiosis and pollen development.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0006281","count":1},{"id":"GO:0006268","count":1},{"id":"GO:0007131","count":1}]},{"hash":"1832427499555477273","title":"Unknown","description":"The top terms show a mix of transport (glucose, myo-inositol), transcription regulation/chromatin modification (even if some terms are obsolete), endocrine signaling (estradiol), neural/learning processes (visual learning), general protein oligomerization, and PDGF signaling regulation, with no clear single function linking the proteins and no edges connecting them. This makes a coherent cluster label unlikely.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":2},{"id":"GO:1901726","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0034720","count":2}]},{"hash":"54525424546944186","title":"Cardiac and vascular development signaling","description":"The terms cluster around heart development, branching morphogenesis of vessels, regulation of heart rate, and smooth muscle signaling, including GPCR and calcium-related pathways, suggesting a shared function in cardiac and vascular development and regulation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051482","count":3},{"id":"GO:0007190","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0045986","count":2},{"id":"GO:0002031","count":2}]},{"hash":"2241603213756546055","title":"Cell Cycle and DNA Replication with Trafficking","description":"The terms point to core cell-cycle processes (mitotic cycle, DNA replication, HR repair) while also highlighting vesicle trafficking (ER\u2013Golgi transport, endocytic recycling) and regulatory GTPase activity, suggesting a cluster of proteins that coordinate genome maintenance with intracellular transport and cell division. The brain development term indicates potential tissue-specific roles in proliferative neural cells.","confidence":"Medium","size":10,"edges":31,"triangles":44,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0007420","count":4}]},{"hash":"1786699069440451520","title":"Ferredoxin-based redox metabolism and nitrogen fixation","description":"The top GO terms cluster around redox reactions and energy metabolism: oxidation-reduction processes, ATP synthesis coupled to electron transport, and ferredoxin metabolism, alongside nitrogen fixation. These points strongly suggest a microbial, ferredoxin-driven energy metabolism core. A few terms about regulation of endothelial processes appear peripheral and may reflect incidental annotations rather than a shared function of the cluster. Overall, the theme is redox-driven energy metabolism with nitrogen fixation.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0009399","count":2},{"id":"GO:1900747","count":2},{"id":"GO:0042773","count":2},{"id":"GO:0006814","count":2}]},{"hash":"37874020086434128","title":"Actin cytoskeleton remodeling during development","description":"The cluster aggregates GO terms centered on actin dynamics: actin filament polymerization, Arp2/3 complex\u2013mediated nucleation, and actomyosin contractile ring activity, along with skeletal muscle fiber development. This points to actin cytoskeleton remodeling during development, particularly in muscle (and to a lesser extent neural) contexts. Some terms (histone modifications, subtelomeric heterochromatin) are less connected to the main theme but do not outweigh the dominant actin-related signals.","confidence":"Medium","size":10,"edges":18,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":4},{"id":"GO:0021762","count":4},{"id":"GO:0043981","count":2},{"id":"GO:0030041","count":2},{"id":"GO:0043486","count":2}]},{"hash":"406730169790121542","title":"Neural development and synaptic plasticity","description":"The top GO terms cluster around neural development and synaptic function, including axonogenesis, Schwann cell development, excitatory postsynaptic potential, and long-term synaptic potentiation, suggesting the proteins are involved in neural differentiation and synaptic signaling. Some terms (cell cycle, dehydration/ABA signaling and heart development) are less coherent with this theme but do not override the primary neural context. ","confidence":"Medium","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":10},{"id":"GO:0060079","count":10},{"id":"GO:0014044","count":10},{"id":"GO:0007601","count":10},{"id":"GO:0010800","count":10}]},{"hash":"452715600625658527","title":"Genome maintenance and DNA replication","description":"The dominant GO terms point to genome stability processes: reciprocal meiotic recombination, DNA replication, telomere maintenance via recombination, and regulation of DNA damage checkpoints. While other terms relate to plant signaling and light responses, the core signal across the cluster is genome maintenance and DNA replication. ","confidence":"High","size":10,"edges":17,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007131","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0000722","count":2},{"id":"GO:1901332","count":2},{"id":"GO:0009584","count":2}]},{"hash":"1456630287238584332","title":"Rac GTPase signaling and cytoskeletal remodeling","description":"The cluster centers on Rac/small GTPase\u2013related processes (positive regulation of GTPase activity, small GTPase\u2013mediated signaling) and cytoskeletal remodeling (dendritic spine development, podosome assembly), with supporting vesicle trafficking and polarity terms (ER to Golgi transport, intracellular transport, epithelial polarity). This suggests a cohesive module where Rac GTPase signaling drives actin dynamics and membrane trafficking to shape cell polarity and synaptic structures.","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0035021","count":3}]},{"hash":"588220324914179775","title":"Neural, muscular, and vascular development","description":"This cluster centers on tissue development across neural, muscular, and vascular systems, with terms for myoblast fusion, Schwann cell development, angiogenesis, visual perception, and synaptic signaling. Some terms reflect general cell proliferation or cross-kingdom noise (abscisic acid signaling), but the dominant pattern is developmental differentiation in multicellular organisms.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007100","count":7},{"id":"GO:0000086","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0007520","count":5},{"id":"GO:0001525","count":5}]},{"hash":"914148395863511818","title":"Embryonic development and tissue morphogenesis","description":"The top terms cluster around embryogenesis and organ/tissue formation across multiple lineages: left/right patterning, rhombomere development, cartilage morphogenesis, placenta and trophoblast differentiation, pancreatic/endocrine system development, and EMT in heart development. Although visual perception appears, the dominant theme is broad embryonic development and morphogenesis, justifying this label.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0003323","count":3}]},{"hash":"208769721018918897","title":"Unknown","description":"The top GO terms cover diverse processes (ribosome biogenesis/assembly, DNA replication, vesicle transport, ERAD, cilium movement) with several obsolete terms, indicating no single coherent functional theme linking the proteins. This lack of a clear common function leads to labeling the cluster as Unknown. ","confidence":"","size":10,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:1990048","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0031412","count":2},{"id":"GO:0003341","count":2}]},{"hash":"783948714253611082","title":"Neuronal development and axon guidance","description":"The terms cluster around neural development and wiring: neurogenesis, axonogenesis, peripheral nervous system axon regeneration, dendrite self-avoidance, and paranode localization. Positive regulation of GTPase activity aligns with cytoskeletal remodeling needed for neurite outgrowth and guidance. Some terms reference photoreceptor and pericyte differentiation, which can relate to neural tissue development and associated vasculature, but the dominant signal points to neuronal differentiation and axon guidance.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0001751","count":5},{"id":"GO:0070593","count":5},{"id":"GO:0021836","count":5},{"id":"GO:1904238","count":5}]},{"hash":"1855844937780051461","title":"Adrenergic and Dopaminergic Neural Signaling","description":"Top GO terms point to dopaminergic synaptic transmission and MAPK-activating adrenergic receptor signaling, with positive regulation of heart rate by epinephrine/norepinephrine and prepulse inhibition, suggesting a neural signaling module governing adrenergic/dopaminergic communication and cardiac regulation. Some associated terms (xenobiotic response, TNF production regulation, diet-induced thermogenesis, enteric muscle differentiation) imply peripheral regulatory interactions, but the dominant theme remains neural signaling via adrenergic and dopaminergic pathways.","confidence":"High","size":10,"edges":17,"triangles":9,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":10},{"id":"GO:0071883","count":10},{"id":"GO:0001996","count":10},{"id":"GO:0048609","count":10},{"id":"GO:0051967","count":10}]},{"hash":"73849754606041271","title":"Unknown","description":"The GO terms cover immune defense, transcriptional regulation, plasminogen activation, growth and vitellogenesis, mitochondrial fission, histone turnover, ER stress\u2013related neuronal apoptosis, zinc homeostasis, and synaptic regulation. This spread indicates no single cohesive function binding the cluster, so a clear, intuitive label is not supported.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0007296","count":2}]},{"hash":"1330378943360694458","title":"Ectodermal Development and Gene Expression Regulation","description":"Top terms point to ectodermal tissue development (eye lens, keratinocytes) and related signaling (Wnt, angiogenesis) with active gene expression (DNA-templated transcription) and genome maintenance (DNA replication/repair). The cluster thus seems to link ectodermal development with transcriptional control and cell cycle processes.","confidence":"Medium","size":10,"edges":42,"triangles":99,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0045766","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0060044","count":3},{"id":"GO:0090263","count":3}]},{"hash":"654744544308156615","title":"Neural development and synapse organization","description":"This cluster is dominated by GO terms for nervous system development, synapse assembly, and cell adhesion (both homophilic and heterophilic), pointing to roles in neural connectivity and synaptic formation. Additional terms on cell junction organization and related processes support a cohesive theme around neural tissue organization, with a few outliers (bone maturation and hair-cycle regulation) that may reflect broader gene functions or annotation overlap. Overall, the neural development/synapse theme is the strongest signal.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":10},{"id":"GO:0043931","count":9},{"id":"GO:0007157","count":9},{"id":"GO:0051965","count":9},{"id":"GO:0007156","count":9}]},{"hash":"504495769447648291","title":"Cofactor and amino acid biosynthesis with Fe-S assembly","description":"Top GO terms point to multiple biosynthetic pathways (heme precursor protoporphyrinogen IX, biotin, amino acids) along with iron-sulfur cluster assembly and maturation, suggesting the proteins act in cofactor biosynthesis and Fe-S biogenesis rather than a single narrow pathway. The transcription term appears ancillary. This combination supports labeling the cluster as cofactor and amino acid biosynthesis with Fe-S assembly.","confidence":"Medium","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006782","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0019878","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0017000","count":2}]},{"hash":"937567417356749171","title":"Amino acid and cofactor biosynthesis","description":"Based on the GO terms, most proteins cluster around biosynthetic pathways: amino acid biosynthesis (proline, tyrosine, alanine), porphyrin/heme and chlorophyll biosynthesis, biotin biosynthesis, and antibiotic biosynthesis. Despite a few catabolic or obsolete terms, the dominant theme is biosynthesis of amino acids and cofactors/pigments, justifying this label.","confidence":"Medium","size":10,"edges":14,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055129","count":4},{"id":"GO:0006782","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0009102","count":3}]},{"hash":"1344901283996355474","title":"DNA replication and cell cycle regulation","description":"The cluster\u2019s top GO terms are dominated by DNA replication, its initiation, and cell division, with supporting signals from protein phosphorylation and complex formation. Metabolic terms for NAD+ and CoA biosynthesis may provide energy and cofactors needed for replication, while oxidative stress response appears as a peripheral theme. Overall, the theme centers on replication and cell cycle control with linked signaling and metabolism.","confidence":"Medium","size":10,"edges":32,"triangles":45,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046940","count":4},{"id":"GO:0046939","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0015937","count":3},{"id":"GO:0006270","count":3}]},{"hash":"2227057472050446004","title":"Neuroinflammation and synaptic plasticity with astrocyte development","description":"This cluster shows strong enrichment for NF-kappaB signaling and innate immune response terms, indicating neuroinflammatory processes, along with long-term potentiation and memory terms pointing to synaptic plasticity. The presence of astrocyte differentiation and EMT terms suggests glial development and remodeling in the CNS, tying inflammation to neuronal plasticity and glial dynamics.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0043123","count":7},{"id":"GO:0060291","count":7},{"id":"GO:0000122","count":6},{"id":"GO:1900026","count":6},{"id":"GO:0051092","count":6}]},{"hash":"1714160484188053753","title":"RNA processing and translation initiation","description":"The top terms are dominated by mRNA splicing and spliceosome regulation, with supporting signals for mRNA modification and formation of translation initiation complexes, suggesting a coherent module centered on RNA processing and early translation steps.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000380","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0042273","count":2},{"id":"GO:0000398","count":2}]},{"hash":"1878127454380214007","title":"Embryonic and organ development","description":"GO terms cluster around developmental and morphogenetic processes across multiple tissues (heart, hindlimb, placenta, gonads, habenula), plus transcriptional regulation during development. This pattern supports a single theme of embryonic and organ development, rather than a specific pathway or tissue.","confidence":"High","size":10,"edges":10,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":8},{"id":"GO:0035116","count":8},{"id":"GO:0001890","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0008584","count":8}]},{"hash":"1611238116473420738","title":"Embryonic Development and Neural Lineage Specification","description":"This cluster centers on developmental processes across tissues, with strong emphasis on neural lineage specification (subpallium neuron fate, spinal cord motor neuron and oligodendrocyte fate, GABAergic interneuron differentiation) and organogenesis (endocrine pancreas, bronchiole, skeletal muscle development). The presence of transcription-related GO terms (RNA polymerase II transcription and its regulation) suggests these proteins participate in developmental gene expression programs that drive lineage decisions, linking transcription control to tissue differentiation.","confidence":"Medium","size":10,"edges":41,"triangles":92,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0006366","count":5},{"id":"GO:0060163","count":4},{"id":"GO:0060435","count":4}]},{"hash":"1686367145804319984","title":"RNA Splicing and rRNA Maturation with DNA Repair","description":"The top terms cluster around RNA processing (spliceosome-mediated splicing and rRNA maturation) and genome maintenance (transcription-coupled nucleotide-excision repair and SOS response), suggesting a core theme of RNA processing linked to DNA damage response. Some terms also indicate neuronal/hair-cell developmental contexts, but the dominant signal is RNA processing with DNA repair.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1990416","count":4},{"id":"GO:0000388","count":4},{"id":"GO:0009432","count":4},{"id":"GO:0006605","count":3},{"id":"GO:0000398","count":3}]},{"hash":"1936086679561438589","title":"Mitochondrial Metabolite and Ion Transport","description":"The cluster is dominated by membrane transport of metabolites and cofactors (ATP, CoA, TPP, glycine, deoxynucleotides) with a strong mitochondrial motif (membrane potential regulation, mitochondrial ATP transport), plus related ion transport and stress response, suggesting a cohesive theme of energy/metabolite movement across membranes. ","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":5},{"id":"GO:0030302","count":3},{"id":"GO:0097274","count":3},{"id":"GO:0035349","count":3},{"id":"GO:0051881","count":3}]},{"hash":"2081597342930756041","title":"Wnt/TGF-\u03b2 Developmental Signaling and ECM Remodeling","description":"This cluster is dominated by GO terms for Wnt signaling and TGF-\u03b2 receptor signaling, along with multiple development-related terms (midbrain, pancreas, biomineral tissue) and an elastin/ECM remodeling signal. The SMAD complex assembly term (obsolete) also points to TGF-\u03b2 pathway involvement. While some immune-related terms appear, the core pattern ties developmental signaling to extracellular matrix remodeling, justifying this label.","confidence":"High","size":10,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0007183","count":3},{"id":"GO:0007179","count":3},{"id":"GO:0031017","count":3}]},{"hash":"932469364943210383","title":"Redox-driven plant carbohydrate and lipid metabolism","description":"The cluster\u2019s top terms hover around redox (oxidation-reduction) processes and diverse carbohydrate and lipid pathways (glucose catabolic processes, sorbitol catabolism, fructose biosynthesis, and fatty acid biosynthesis), with plant-specific anthocyanin biosynthesis also present. This suggests a coherent metabolic module in plants where redox state coordinates primary carbohydrate and lipid metabolism, with minor stress-related signaling components (e.g., LPS response). While some terms are obsolete or cross-species hints, the dominant theme is redox-linked metabolism in plants.","confidence":"Medium","size":10,"edges":21,"triangles":19,"max_degree":7,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0032496","count":4},{"id":"GO:0009718","count":3},{"id":"GO:0046370","count":3},{"id":"GO:0046294","count":3}]},{"hash":"1819126901830256304","title":"Angiogenesis and wound healing","description":"This cluster repeatedly shows GO terms tied to blood vessel formation and tissue repair, such as positive regulation of angiogenesis, sprouting angiogenesis, leukocyte migration in inflammatory response, wound healing, and PDGF receptor signaling with fibroblast proliferation. While some terms touch on broad development (post-embryonic development, endodermal differentiation), the predominant theme centers on angiogenesis, cell migration, and tissue remodeling.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0002523","count":4},{"id":"GO:0007044","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0002042","count":3},{"id":"GO:0009791","count":3}]},{"hash":"183858851751850603","title":"Cell Division and Vesicle Trafficking","description":"The cluster includes processes tied to mitosis and chromosome handling (cell division, CENP-A chromatin assembly, microtubule severing) along with cytoskeleton regulation (GTPase activity) and membrane trafficking (ER-to-Golgi transport, endocytosis). This mix suggests a theme around coordination between chromosome segregation and intracellular trafficking, so the label reflects a focused, but broad, functional grouping. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051260","count":2},{"id":"GO:0061641","count":2}]},{"hash":"2127470994674835734","title":"Sensory development and ion transport signaling","description":"This cluster's top GO terms cluster around sensory biology\u2014sensory perception of pain and inner ear development\u2014together with ion transport (sodium/potassium) and cyclic nucleotide signaling (cAMP/cGMP, guanylyl cyclase pathway). The combination suggests roles in sensory organ development with regulation of ion channels and signaling cascades, rather than a single isolated process. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0007275","count":9},{"id":"GO:0006349","count":8},{"id":"GO:0048839","count":8},{"id":"GO:0098719","count":7}]},{"hash":"88364193374857624","title":"Multisystem Homeostasis Regulators","description":"GO terms point to regulatory roles across heart rate and blood pressure, appetite, pain, fatty acid import, renal function, GI epithelium maintenance, and T cell activation. The common thread is modulation of physiological homeostasis across multiple organ systems, rather than a single pathway, justifying a label of multisystem homeostasis regulators.","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0010459","count":1},{"id":"GO:0032099","count":1},{"id":"GO:0051930","count":1}]},{"hash":"839488176509676663","title":"Immune-Inflammatory Signaling and Tissue Remodeling","description":"The top GO terms point to active immune responses (complement activation, acute inflammatory response, immunological synapse formation, cytokine regulation, apoptotic cell clearance) and extracellular matrix/tissue remodeling (collagen fibril organization, integrin signaling). There are also vascular/renal regulatory terms (ANP-mediated blood pressure regulation, renal sodium excretion) and organ development signals (lung development), suggesting a cluster of immune activity linked with tissue remodeling and distant cardiovascular/renal regulation. Confidence: Medium","confidence":"","size":10,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0003050","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0030199","count":5},{"id":"GO:0001771","count":5},{"id":"GO:0035813","count":5}]},{"hash":"1280994279952093756","title":"Circadian-regulated energy metabolism and light sensing","description":"This cluster centers on mitochondrial function and energy production (axonal transport of mitochondrion; aerobic respiration regulation; intracellular oxygen homeostasis) and circadian biology (positive regulation of circadian rhythm), with a notable light-sensing term (detection of visible light). Together these suggest proteins involved in coordinating metabolism with circadian timing and light cues. Some other terms relate to tissue remodeling or differentiation, which may reflect broader context-specific roles but are less central to the core theme. ","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019896","count":10},{"id":"GO:0032364","count":10},{"id":"GO:1903715","count":10},{"id":"GO:0042753","count":10},{"id":"GO:0002248","count":10}]},{"hash":"337429137518668941","title":"Multi-tissue morphogenesis and ECM remodeling","description":"Most top GO terms describe development and morphogenesis in various tissues (eye, skin, cerebellum, thyroid, endoderm) and extracellular matrix organization/signaling (collagen fibril organization, collagen-activated signaling), suggesting a cluster tied to tissue formation with ECM involvement.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034198","count":3},{"id":"GO:0048593","count":2},{"id":"GO:0043589","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0038063","count":2}]},{"hash":"957159681550792241","title":"Phagocytosis and Complement Activation","description":"The proteins are enriched for innate immune functions: cellular response to fungal molecules, phagocytosis recognition and regulation, and lectin pathway complement activation. Additional signals related to collagen/ECM and platelet activation suggest inflammation and tissue remodeling accompany the immune response. Overall, the core theme centers on phagocytosis and complement in innate immunity, with some ECM-associated signaling. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":8},{"id":"GO:0001502","count":7},{"id":"GO:0010572","count":6},{"id":"GO:0038063","count":6},{"id":"GO:0006910","count":5}]},{"hash":"2149865497698075766","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"Top terms indicate ubiquitin-mediated protein catabolic processes with specific linkages (K6, K63) and autoubiquitination, plus references to NF-kappaB pathway regulation and interferon-beta response. This suggests a cohesive cluster centered on ubiquitin-driven protein turnover and modulation of NF-\u03baB signaling.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0051092","count":4},{"id":"GO:0085020","count":4},{"id":"GO:0043123","count":4}]},{"hash":"289249716188809626","title":"Dopamine-Responsive Neural Signaling and Development","description":"The top GO terms point to neuronal development and signaling, including nervous system development, dopamine response, and MAPK/JNK signaling pathways (ERK1/2 cascade, Roundabout axon guidance). These collectively suggest a module of neural signaling, differentiation, and cytoskeletal regulation in neurons, rather than a general non-neural process. Even the obsolete terms align with MAPK/PI3K\u2013related regulation within neural contexts, reinforcing a coherent neural signaling and development theme.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000186","count":10},{"id":"GO:0007399","count":9},{"id":"GO:0031647","count":9},{"id":"GO:0070374","count":9},{"id":"GO:1903351","count":9}]},{"hash":"509128244957471342","title":"Neural adhesion and synapse formation","description":"The cluster is enriched for nervous system development, synaptic transmission, and positive regulation of synapse assembly, along with cell\u2013cell adhesion terms. This points to proteins involved in neuronal connectivity and synapse formation, with supporting hints from sensory (sound) detection terms. Some immune and bone-related terms appear but are less central to the main neural theme, so the core interpretation is neural adhesion and synapse organization.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":5},{"id":"GO:0043931","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0007156","count":4}]},{"hash":"1518233311688013896","title":"Neuronal development and synaptic adhesion","description":"The GO terms cluster around brain and nervous system development, glutamatergic synaptic transmission, synapse assembly, and cell\u2013cell adhesion, with GTPase activity regulation supporting neurite outgrowth and synaptic remodeling. An outlier term about ossification appears, but the dominant signal points to neural development and synaptic function.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0043931","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1599120400794606641","title":"Neural development and axon guidance","description":"The proteins in this cluster are primarily associated with neural differentiation and axon patterning, including photoreceptor differentiation, neurogenesis, axonogenesis, dendrite self-avoidance, interneuron chemorepulsion, and paranode-localization of proteins. While there are some terms related to extracellular matrix and vascular components (collagen fibril organization, pericyte differentiation), the dominant signal is neural development and axon guidance, suggesting a cohesive role in neuronal formation and pathfinding. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0001751","count":6},{"id":"GO:0070593","count":6},{"id":"GO:0021836","count":6},{"id":"GO:1904238","count":6},{"id":"GO:0042698","count":6}]},{"hash":"2220911080957352540","title":"Cardiac development and electrical signaling","description":"The top GO terms point to calcium-triggered cardiomyocyte contraction, cardiac conduction system activity (SA node, atrial, and Purkinje signaling), and heart outflow tract morphogenesis, all reflecting cardiac development and electrical signaling. While some terms relate to broader development or other tissues, the heart-focused terms dominate, supporting this label.","confidence":"High","size":10,"edges":15,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0014808","count":9},{"id":"GO:0086029","count":9},{"id":"GO:0003151","count":9},{"id":"GO:0007275","count":9},{"id":"GO:0098910","count":9}]},{"hash":"1669396989668228189","title":"Endothelial lipid transport and cadherin signaling","description":"The cluster is enriched for lipoprotein metabolic process and lipid transport, with endothelial cell activation and cadherin-mediated adhesion terms pointing to vascular lipid handling and cell-cell adhesion dynamics. Additional hints from actin/Rho signaling and endomembrane organization suggest membrane trafficking and cytoskeletal coordination in endothelial contexts. The lack of edges means this label reflects a dominant GO theme rather than direct interactions; some terms may be noise. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042157","count":2},{"id":"GO:0042118","count":2},{"id":"GO:0006869","count":2},{"id":"GO:0051666","count":1},{"id":"GO:0000282","count":1}]},{"hash":"2235887758497905136","title":"Embryonic organ development and heart morphogenesis","description":"The top GO terms point to embryonic tissue morphogenesis, especially heart development (endocardial EMT, vasculogenesis) and related organ formation (placenta, uterine glands). Some terms also reflect neural differentiation (gliogenesis, dendrite development) and cell adhesion, suggesting a broader role in tissue morphogenesis and cellular organization during development. Overall, the cluster seems to represent embryonic organ development with a focus on cardiac morphogenesis.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0045605","count":3},{"id":"GO:0060669","count":3},{"id":"GO:0035441","count":3}]},{"hash":"1911238576364679765","title":"Actin-driven cell migration and polarity","description":"The cluster\u2019s top GO terms cluster around actin filament bundle assembly, establishment of epithelial cell polarity, and cell migration, which together point to cytoskeletal remodeling and coordinated polarity during movement. Other terms like endothelial delamination and stress responses are present but secondary to the core actin-migration-polality theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0070427","count":3}]},{"hash":"847088132100016689","title":"Chondrogenesis and angiogenesis","description":"The top GO terms center on cartilage formation (cartilage condensation, chondrocyte differentiation) and vascular development (labyrinthine layer blood vessel development, angiogenesis), suggesting proteins involved in skeletal tissue development with accompanying blood vessel formation. Although neural-related terms appear (dendritic spine morphogenesis, protein localization to synapse), the dominant signal is cartilage formation and associated angiogenesis, making this a cohesive developmental cluster for skeletal tissue with vascularization. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060716","count":7},{"id":"GO:0045766","count":6},{"id":"GO:0008285","count":6},{"id":"GO:0001502","count":6},{"id":"GO:0014068","count":6}]},{"hash":"1949278802736142496","title":"Neuronal excitability and synaptic signaling","description":"These proteins cluster around neural signaling and excitability: ion channels for sodium and potassium transport, excitatory postsynaptic potentials, GABA signaling, and mechanosensory perception related to sound, plus behavioral outputs like locomotion and taste aversion. This pattern points to a coherent nervous system\u2013related function rather than immune or metabolic roles, justifying a name focused on neuronal signaling. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":5},{"id":"GO:0060079","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0001661","count":4}]},{"hash":"1221802320804246167","title":"Plant cell wall polysaccharide biosynthesis","description":"This cluster is dominated by plant-specific biosynthetic processes for cell wall components (glucuronoxylan, homogalacturonan, mucilage) and plant-type secondary cell wall biogenesis, plus associated protein O-linked glycosylation. These terms collectively point to construction and modification of plant cell walls, with one outlier term likely incidental. ","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010417","count":4},{"id":"GO:0006012","count":4},{"id":"GO:0010289","count":4},{"id":"GO:0035269","count":4},{"id":"GO:0009834","count":4}]},{"hash":"2135751472491939629","title":"Neuroendocrine Stress and Thermogenesis","description":"The terms cluster around temperature-related responses and neuroendocrine signaling (diet-induced thermogenesis, cellular response to temperature, adrenergic signaling, dopaminergic transmission, heart rate regulation by catecholamines), with accompanying immune and xenobiotic response terms. This pattern suggests a cohesive theme of stress-related metabolic and autonomic signaling, rather than unrelated processes, though some items like reproductive processes are peripheral. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":4},{"id":"GO:0006955","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0001963","count":3}]},{"hash":"1867269586933969739","title":"Skeletal and dental morphogenesis","description":"The cluster centers on developmental processes that shape skeletal and dental tissues (skeletal system development, odontogenesis) and related morphogenesis such as heart valve formation, with supporting terms on VEGF regulation and muscle differentiation, suggesting a cohesive theme of tissue formation rather than metabolism or signaling alone.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0006508","count":2},{"id":"GO:0043011","count":2},{"id":"GO:0042475","count":2}]},{"hash":"102293904394617544","title":"Galactose/UDP-galactose metabolism cluster","description":"Most terms point to galactose and UDP-galactose metabolism (UDP-galactose biosynthesis, galactose catabolic via UDP-galactose, galactose homeostasis, carbohydrate phosphorylation). A single transcription regulation term appears, but the dominant pattern is carbohydrate metabolism centered on galactose/UDP-galactose, suggesting these proteins collectively relate to galactose utilization pathways.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0033501","count":1},{"id":"GO:0006006","count":1},{"id":"GO:0006258","count":1},{"id":"GO:0042125","count":1}]},{"hash":"1738690604086409897","title":"Fungal beta-glucan biosynthesis and mating","description":"The cluster shows strong fungal-specific signals, notably fungal-type cell wall beta-glucan biosynthesis and karyogamy (conjugation with cellular fusion), pointing to roles in cell wall construction and mating-related nuclear fusion. Although there are generic terms like DNA replication and iron-sulfur cluster assembly, the prominent fungal processes suggest a fungal development/mating focus.","confidence":"High","size":9,"edges":26,"triangles":45,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":8},{"id":"GO:0006260","count":8},{"id":"GO:1903382","count":7},{"id":"GO:0000742","count":7},{"id":"GO:0000902","count":7}]},{"hash":"580891814115414696","title":"Fungal DNA replication and protein quality control","description":"The top GO terms are dominated by DNA replication, with additional related terms tied to protein folding, ER stress response, and protein targeting, suggesting a set of fungal proteins involved in chromosomal maintenance and general protein homeostasis under stress. While there are a few fungus-specific processes (cell wall biosynthesis, karyogamy) that are less clearly connected, the core themes point to replication-associated functions with broad quality-control roles. Confidence: Medium","confidence":"","size":9,"edges":23,"triangles":25,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0070389","count":3},{"id":"GO:1903382","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0090084","count":2}]},{"hash":"2081651611042526128","title":"Glycolysis and Carbohydrate Metabolism","description":"The majority of top GO terms center on glycolysis and carbohydrate processing\u2014canonical glycolysis, glycogen breakdown, fructose-6-phosphate metabolism, and carbohydrate phosphorylation\u2014indicating a primary link to central carbon metabolism. Additional terms about menaquinone biosynthesis, nicotinate nucleotide salvage, nitrogen utilization, uracil catabolism, and antibiotic biosynthesis appear but are secondary or context-dependent, suggesting a cluster enriched for carbohydrate metabolism with broader metabolic capabilities.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":3},{"id":"GO:0061621","count":3},{"id":"GO:0093001","count":3},{"id":"GO:0005980","count":3},{"id":"GO:0046835","count":3}]},{"hash":"1417094779479671750","title":"Paranodal Axon Junctions and Adhesion","description":"The top GO terms cluster around paranodal junction assembly, juxtaparanode axon localization, and both homophilic and heterophilic cell\u2013cell adhesion, with supporting terms on synapse assembly and neural development. This points to proteins involved in organizing axon\u2013glia boundaries and adhesion at myelinated fibers, i.e., paranodal/juxtaparanodal domains and neuronal connections. Some bone development terms appear as broader developmental signals but do not override the neural adhesion focus.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021836","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0071205","count":5},{"id":"GO:0048661","count":5},{"id":"GO:0043931","count":5}]},{"hash":"1650483020922151618","title":"Mitochondrial redox balance and metabolism","description":"Given the prominence of GO terms related to redox homeostasis, detoxification of oxidants, response to toxic substances, and regulation of mitochondrial membrane potential, the cluster appears centered on mitochondrial function and oxidative stress management. Additional terms such as homogentisate catabolic process and chloride transport hint at metabolic and membrane activities that support this core function. Some terms (platelet aggregation, translation) are less cohesive with the main theme, but do not override the primary signal.","confidence":"Medium","size":9,"edges":24,"triangles":30,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":3},{"id":"GO:0006289","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0009636","count":3}]},{"hash":"214234477242637837","title":"Developmental Morphogenesis and Immune Signaling","description":"The top GO terms cluster around tissue development and morphogenesis (cartilage condensation, metanephric tubule morphogenesis, lymph vessel morphogenesis) with concurrent immune/modulatory activity (complement activation, phagocytosis recognition, platelet activation regulation, arachidonate secretion). This suggests a theme of organ/tissue formation coupled with inflammatory/immune signaling.","confidence":"Medium","size":9,"edges":32,"triangles":59,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":9},{"id":"GO:0001502","count":8},{"id":"GO:0090238","count":6},{"id":"GO:0060355","count":6},{"id":"GO:0010572","count":6}]},{"hash":"876174239649226630","title":"Kinase/Phosphatase Regulation in Development","description":"The cluster is dominated by GO terms for protein dephosphorylation and negative regulation of phosphorylation/kinase activity, pointing to regulatory proteins that modulate phosphorylation states. Additional terms cover developmental processes (axonogenesis, morphogenesis) and stress/hormonal responses (glucocorticoid, hypoxia), suggesting a common theme of phosphorylation-controlled signaling in development and stress responses.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":4},{"id":"GO:0010801","count":3},{"id":"GO:0051384","count":3},{"id":"GO:0051281","count":3},{"id":"GO:0007409","count":3}]},{"hash":"1504580874345147467","title":"Embryonic development signaling and organogenesis","description":"This cluster is dominated by GO terms for ERK/MAPK and Wnt signaling, plus several embryonic organogenesis processes (retina morphogenesis, cartilage condensation, thyroid development, nervous system/forebrain development, digestive tract development). The common thread is involvement in key developmental signaling pathways that drive embryogenesis and organ formation, suggesting the proteins coordinate developmental processes.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0070371","count":4},{"id":"GO:0060059","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0001502","count":3}]},{"hash":"1759400592129232881","title":"Unknown","description":"Top terms span RNA processing/modification, protein methylation, and diverse biosynthetic pathways (cobalamin, phylloquinone, antibiotic, valine catabolism), with several obsolete terms. There is no single cohesive function that ties these proteins together, so a concise, representative label cannot be determined.","confidence":"","size":9,"edges":29,"triangles":46,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:2000648","count":3},{"id":"GO:0060303","count":3},{"id":"GO:0030488","count":2},{"id":"GO:0006479","count":2}]},{"hash":"832240419727554381","title":"Ribosome Biogenesis and Nuclear Export","description":"Most top GO terms cluster around ribosome assembly and export from the nucleus (ribosomal large/small subunit biogenesis and export; regulation of protein export from nucleus). This suggests proteins in the cluster are involved in ribosome maturation and nucleocytoplasmic transport. A few terms appear unrelated (axon regeneration, leukocyte chemotaxis, ovulation), likely noise or broader associations.","confidence":"Medium","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0034501","count":3},{"id":"GO:0046827","count":3},{"id":"GO:0000056","count":2}]},{"hash":"2260170028198451949","title":"Transcription-Translation Coordination and Fidelity","description":"This cluster combines transcription-related activities (DNA-templated transcription, transcription termination, transcription antitermination) with translation machinery (translation, ribosome biogenesis, tyrosyl-tRNA aminoacylation) and fidelity maintenance (positive regulation of translational fidelity, maintenance of translational fidelity), suggesting a coherent module that links transcription and translation and ensures accurate protein synthesis, with a contextual heat response term.","confidence":"High","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0045903","count":2},{"id":"GO:0006437","count":2}]},{"hash":"507560939041404727","title":"Signaling Pathway Regulation","description":"Proteins in this cluster largely map to various signaling and regulatory processes, including MAPK-like/osmosensory signaling, Rap signaling, adenylate cyclase/cAMP pathways, NF-kappaB regulation, and lipid-mediated signaling (diacylglycerol and inositol phosphate metabolism). While a few terms touch development or pigment synthesis, the common theme is modulation of signal transduction and related lipid signaling pathways rather than a single specific function.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000161","count":1},{"id":"GO:0048022","count":1},{"id":"GO:0032486","count":1},{"id":"GO:0071880","count":1},{"id":"GO:0032835","count":1}]},{"hash":"1232460887116635815","title":"Immune signaling and antigen processing","description":"The top GO terms point strongly to immune-related pathways: T cell receptor signaling, TNF signaling, Fc-epsilon receptor signaling, and MHC class I antigen processing/presentation, together with ubiquitin-proteasome\u2013related protein turnover and mRNA stability regulation. While hints of plant defense and Wnt signaling appear, the dominant theme is immune response and antigen presentation.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":7},{"id":"GO:0043488","count":6},{"id":"GO:0010363","count":6},{"id":"GO:0038095","count":6},{"id":"GO:0002479","count":6}]},{"hash":"1828019165229165120","title":"mRNA processing and translation initiation","description":"This cluster centers on RNA processing and translation initiation, with GO terms for mRNA modification, alternative splicing, splice-site recognition, mRNA stabilization, and assembly of translation initiation machinery (preinitiation complex, eIF4F) and translation reinitiation, indicating a cohesive role in post-transcriptional regulation and initiation of protein synthesis.","confidence":"High","size":9,"edges":15,"triangles":8,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0016556","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0097010","count":3},{"id":"GO:1902625","count":3},{"id":"GO:1905663","count":3}]},{"hash":"1446916591420067519","title":"Neuronal Ion Channel Clustering and Membrane Localization","description":"This cluster centers on membrane-associated processes: clustering of neurotransmitter-gated ion channels, calcium transmembrane transport, phosphorylation, and localization to adherens junctions and myelin sheaths, together with polarity maintenance and basic signaling. The mix suggests neural and epithelial membrane organization and signaling.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072578","count":6},{"id":"GO:1903753","count":6},{"id":"GO:0045197","count":6},{"id":"GO:0071896","count":6},{"id":"GO:0035750","count":6}]},{"hash":"582752386316607591","title":"Neuronal synapse assembly and signaling","description":"The GO terms cluster around postsynaptic membrane assembly, neuroligin/gephyrin clustering, and neurotransmitter secretion, with links to dendrite morphogenesis, neural development, and behavior, indicating a shared role in synapse formation and neuronal communication.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048814","count":1},{"id":"GO:0097104","count":1},{"id":"GO:1903543","count":1},{"id":"GO:0060134","count":1},{"id":"GO:0001843","count":1}]},{"hash":"2150663458438595142","title":"Embryonic Organogenesis and Differentiation","description":"This cluster's terms center on development and morphogenesis across multiple organs\u2014brain regions (medulla oblongata, midbrain dopaminergic neurons), kidney (metanephros morphogenesis, renal vesicle formation), and heart-related structures (bundle of His-Purkinje adhesion, cardiac outflow tract proliferation). Additional terms reflect signaling and structural organization (Wnt signaling, intermediate filament assembly, vesicle-related processes) that underpin organ formation and differentiation. While the themes span several tissues, the common thread is embryonic organogenesis and differentiation, giving moderate confidence in the label.","confidence":"Medium","size":9,"edges":21,"triangles":12,"max_degree":7,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":5},{"id":"GO:0097711","count":4},{"id":"GO:0021550","count":4},{"id":"GO:0003338","count":4},{"id":"GO:0086073","count":4}]},{"hash":"1095789431122347383","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2}]},{"hash":"1656951541881675072","title":"Neuronal development and synaptic function","description":"The dominant terms point to nervous system development, synapse assembly, and nerve impulse transmission, with supporting cell-adhesion terms, suggesting a cluster focused on neuron formation and synaptic connectivity. Some outliers (bone ossification, neutrophil extravasation) may reflect broad annotations rather than core function. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0007157","count":3},{"id":"GO:2000391","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0043931","count":3}]},{"hash":"185465109622041103","title":"GPCR Signaling in Inflammation and Pain","description":"This cluster centers on G-protein coupled receptor signaling and downstream pathways (adenylate cyclase activation, ERK cascade, GPCR internalization, Rho signaling), with accompanying terms for neutrophil chemotaxis, blood coagulation, and dopaminergic synaptic transmission. The shared theme is GPCR-mediated communication coordinating inflammatory/pain responses and related physiological processes.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0045986","count":4},{"id":"GO:0002031","count":4}]},{"hash":"690549602988550212","title":"Central carbon metabolism and energy production","description":"The top GO terms show clear links to energy-yielding pathways: glycolytic process, the TCA cycle, and regulation of pyruvate decarboxylation to acetyl-CoA, indicating core central carbon metabolism. While there are additional terms related to amino acid and neurotransmitter catabolism (proline, GABA, putrescine) and a couple development terms that may reflect annotation noise, the dominant theme is energy metabolism. Confidence: High","confidence":"","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0021983","count":2},{"id":"GO:0009447","count":2},{"id":"GO:0003007","count":2},{"id":"GO:0055129","count":2}]},{"hash":"2223991635097852166","title":"Steroid hormone biosynthesis and metabolism","description":"The top GO terms are centered on production and metabolism of steroid hormones (testosterone biosynthetic process, androgen metabolic process, ecdysone biosynthetic process, progesterone metabolic process), indicating a cohesive theme around steroid biosynthesis/metabolism. Some development-related terms appear among the few other listed terms, but the steroid-related terms are the dominant signal, justifying the label.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":3},{"id":"GO:0008209","count":3},{"id":"GO:0070365","count":3},{"id":"GO:0061298","count":3},{"id":"GO:0055114","count":2}]},{"hash":"421953259284941142","title":"Unknown","description":"The GO terms are too diverse to form a single cohesive function. Immune-related signals (GM-CSF response, NK T cell differentiation, prostaglandin response) appear alongside apoptosis, proteasomal degradation, extracellular matrix metabolism, placental development, and cardiac growth regulation, with no clear shared pathway or process connecting them. The small connectivity (one edge) further suggests no well-defined cluster-wide function.","confidence":"","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097011","count":4},{"id":"GO:2001275","count":3},{"id":"GO:0032436","count":3},{"id":"GO:0001865","count":3},{"id":"GO:0071380","count":3}]},{"hash":"926260731660980378","title":"Neuronal Calcium-Dependent Synaptic Signaling and Plasticity","description":"The set centers on calcium signaling, neurotransmitter release, and long-term synaptic potentiation, with supporting pathways in PI signaling, Rho/actin remodeling, and calcineurin-NFAT, all indicative of neuronal synaptic transmission and plasticity.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0071277","count":4},{"id":"GO:0007269","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0043065","count":4}]},{"hash":"1425151084938831856","title":"Transcription Regulation in Development and Stress","description":"The top GO terms point to DNA-templated transcription and regulation of transcription by RNA polymerase II, suggesting a core function as transcriptional regulators. The presence of neural development terms (brain segmentation, rhombomere 6 development) alongside stress-related responses (xenobiotic stimulus, hydrogen peroxide, glutathione biosynthesis) implies a cluster of regulators that participate in developmental programs while also integrating oxidative or chemical stress signals. Overall, the set seems to reflect transcriptional regulators with roles in development and stress response rather than a single, narrow pathway.","confidence":"Medium","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0045872","count":6},{"id":"GO:0000117","count":4},{"id":"GO:0035690","count":4},{"id":"GO:0070301","count":4}]},{"hash":"1983930671915156733","title":"BMP/TGF-beta signaling in bone and cartilage development","description":"The cluster centers on BMP and TGF-beta signaling regulation, including SMAD-related and TGF-beta receptor pathways, with overlapping roles in osteoblast and chondrocyte differentiation. The mix of positive and negative BMP/TGF-beta regulation alongside differentiation terms points to a cohesive skeletal-development function.","confidence":"High","size":9,"edges":11,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010991","count":4},{"id":"GO:0042347","count":4},{"id":"GO:0030514","count":4},{"id":"GO:0030512","count":4},{"id":"GO:0060710","count":4}]},{"hash":"1237834810983361505","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000721","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0030511","count":3},{"id":"GO:0000467","count":2},{"id":"GO:0035886","count":2}]},{"hash":"797669889731380823","title":"Steroid and lipid biosynthesis","description":"Most GO terms converge on biosynthesis and metabolism of small-molecule compounds, including macrolide biosynthesis and steroid/lipid pathways (ecdysone, progesterone, retinoic acid, bile acids), with several other terms indicating stress or developmental responses that are ancillary.","confidence":"Medium","size":9,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033068","count":9},{"id":"GO:0006697","count":9},{"id":"GO:0042448","count":9},{"id":"GO:0010193","count":9},{"id":"GO:0071615","count":9}]},{"hash":"1421357309514812565","title":"GPCR Signaling and Stress Responses","description":"The cluster top terms are dominated by G protein-coupled receptor signaling pathways (opsin, adenosine, and adrenergic receptor signaling) and downstream cAMP-related activity, with additional enrichment for stress-related processes (ER unfolded protein response and inflammatory response). This suggests a cohesive theme around GPCR-mediated signaling intertwined with cellular stress and inflammatory responses, despite a few more general terms like retina development and magnesium ion response that appear incidental. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032026","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0030968","count":3},{"id":"GO:0010842","count":2},{"id":"GO:0052565","count":2}]},{"hash":"976670179521396278","title":"Ubiquitin-Linked Regulation of Protein Fate and Autophagy","description":"The cluster centers on ubiquitin-related regulation (protein monoubiquitination) and trafficking/localization (autophagosome localization, tRNA export/import), with supporting links to nuclear signaling (glucocorticoid pathway) and immune regulation (T cell anergy). This points to a theme of ubiquitin-mediated control of protein fate and intracellular transport, spanning both autophagy and nuclear-cytoplasmic processes.","confidence":"Medium","size":9,"edges":31,"triangles":53,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:2000235","count":7},{"id":"GO:0006513","count":7},{"id":"GO:0061753","count":7},{"id":"GO:0030579","count":7},{"id":"GO:0002669","count":7}]},{"hash":"1938441622395585024","title":"Neural and Sensory Organ Development","description":"The top GO terms point to developmental processes across neural and sensory tissues (dorsal spinal cord, brain, midbrain, retina, camera-type eye) and related organogenesis, plus general multicellular development and transcriptional regulation. While there are other organ development terms (lung, pancreas, gonad), the overall theme is developmental programs governing neural and sensory organ formation, supported by transcriptional activity. This makes \"Neural and Sensory Organ Development\" a concise, representative label.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021516","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0006366","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0060041","count":5}]},{"hash":"228155643900312189","title":"Ubiquitin-Proteasome\u2013Mediated Cell Cycle Regulation","description":"Most frequent GO terms describe ubiquitin-dependent protein catabolic processes, including autoubiquitination and SCF-dependent proteasomal degradation, indicating active protein turnover via the ubiquitin-proteasome system. The presence of mitotic and meiotic cell cycle terms (mitotic cell cycle, metaphase/anaphase transitions, sister chromatid movement) suggests this cluster centers on degradation of regulatory proteins to control cell cycle progression. A few terms about vacuole fusion and older obsolete terms hint at broader vesicle trafficking but do not override the central theme. Overall, the cluster seems to reflect proteostasis linked to cell-cycle control.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0030433","count":3},{"id":"GO:1902104","count":2},{"id":"GO:0031146","count":2}]},{"hash":"144804748952287594","title":"Signaling and cytoskeletal remodeling","description":"The cluster is enriched for several signaling pathways (T cell receptor, EGFR, Wnt) alongside processes tied to cytoskeletal dynamics (filopodium and podosome assembly) and membrane trafficking (endocytosis, engulfment of apoptotic cells). This suggests proteins that coordinate membrane-initiated signaling with actin-driven remodeling, relevant to immune signaling, cell migration, and development. Some terms reflect broader roles in development and synaptic plasticity, but the common theme centers on signaling-driven cytoskeletal and membrane dynamics.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0050852","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0006897","count":5},{"id":"GO:0071803","count":5},{"id":"GO:0007173","count":5}]},{"hash":"2182570068363041354","title":"Developmental cell adhesion and migration","description":"The top GO terms point to cell adhesion and cellular movement during development (heterophilic adhesion, receptor clustering, axonal defasciculation, sprouting angiogenesis, negative chemotaxis) plus differentiation and tissue remodeling (endodermal differentiation, fibroblast proliferation). While a memory term is less cohesive, the overall theme centers on how cells adhere, migrate, and organize during development and tissue formation. Confidence: Medium","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007613","count":3},{"id":"GO:0002042","count":3},{"id":"GO:0007414","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0007157","count":3}]},{"hash":"2039433446206405008","title":"Neural development and axon guidance","description":"This cluster centers on nervous system development, neuronal migration, dendrite patterning, and axon localization (neurogenesis, nervous system development, dendrite self-avoidance, chemorepulsion in olfactory bulb interneurons, paranode region localization). It also includes Rho signaling and membrane dynamics that drive cytoskeletal remodeling, plus ECM/collagen remodeling that supports guidance. ","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":"cytokinesis","top_go_terms":[{"id":"GO:0001778","count":6},{"id":"GO:0035023","count":5},{"id":"GO:0007252","count":5},{"id":"GO:0016525","count":5},{"id":"GO:0070593","count":4}]},{"hash":"1975420694101554476","title":"AGP glycosylation and seed coat mucilage biosynthesis","description":"The cluster shows a concentration of GO terms around arabinogalactan protein metabolism, seed coat mucilage biosynthesis, and various glycosylation processes (including hydroxyproline O-glycosylation and poly-N-acetyllactosamine biosynthesis), suggesting a coherent theme of plant cell wall glycoprotein production and AGP-related development (e.g., root hair formation). Some terms reference insect or epithelial contexts, which are likely outliers, but the prevailing signal supports AGP glycosylation and seed coat mucilage biosynthesis as the core function.","confidence":"Medium","size":9,"edges":27,"triangles":37,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0048354","count":2},{"id":"GO:0010405","count":2},{"id":"GO:0007299","count":2},{"id":"GO:0001744","count":2},{"id":"GO:0010493","count":2}]},{"hash":"2210510464124117172","title":"Musculoskeletal and Neural Development Signaling","description":"The top GO terms cluster around skeletal system development, BMP signaling, and osteoblast differentiation, indicating osteogenesis. It also includes myelination and synapse assembly, pointing to neural development, with ERK cascade regulation acting as a shared signaling hub; some immune-related LPS signaling appears but is less central.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0030513","count":5},{"id":"GO:0042552","count":5},{"id":"GO:0045669","count":4}]},{"hash":"1947563322274705635","title":"GTPase-mediated actin remodeling in immune cells","description":"This cluster centers on small GTPase signaling (Rho/Rac/Ras), which governs actin cytoskeleton dynamics such as lamellipodium assembly, coupled with immune functions like NK T cell differentiation, B cell maturation, and adaptive immune responses. The co-occurrence of actin remodeling terms and adaptive immune terms suggests a coherent theme of GTPase-driven cytoskeletal changes during immune cell signaling and responses.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0098761","count":5},{"id":"GO:0035020","count":5},{"id":"GO:0032633","count":5},{"id":"GO:0001865","count":5}]},{"hash":"681147218865672238","title":"Rab GTPase signaling and geranylgeranylation","description":"Top terms cluster around Rab signaling, GTPase activation, and protein geranylgeranylation, indicating Rab-dependent vesicle trafficking and membrane targeting as the core function of this cluster. While a few terms relate to zebrafish developmental processes, the dominant theme is Rab-mediated trafficking and its prenylation. ","confidence":"High","size":9,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032482","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0050771","count":3},{"id":"GO:0090630","count":2},{"id":"GO:0048798","count":2}]},{"hash":"460306984972960694","title":"Calcium signaling and NFAT regulation in neural development","description":"The top GO terms point to calcium-dependent signaling (postsynaptic calcium, cellular response to calcium, calcineurin-NFAT regulation) and related pathways (NO synthase regulation, ROS signaling) alongside neural/glial differentiation (astrocyte differentiation) and brain development cues, suggesting a cohesive neural development program driven by calcium/NFAT signaling.","confidence":"Medium","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001569","count":3},{"id":"GO:0051000","count":3},{"id":"GO:0042994","count":2},{"id":"GO:0048855","count":2},{"id":"GO:0099566","count":2}]},{"hash":"1009848239549995007","title":"Developmental chromatin remodeling and nuclear import","description":"This cluster centers on chromatin state regulation linked to transcription initiation (chromatin remodeling) and on nuclear import (NLS-bearing proteins), together with signals related to chromosome maintenance (centromeric cohesion). The presence of organ development terms across different tissues (root development, superior colliculus development, renal outer medulla development, zona limitans intrathalamica formation) suggests a broader role for chromatin regulation during development, with a minor outlier related to indole-3-methanol response that does not define the overall theme.","confidence":"Medium","size":9,"edges":16,"triangles":9,"max_degree":8,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0070602","count":6},{"id":"GO:0071681","count":6},{"id":"GO:0048364","count":6},{"id":"GO:0022006","count":6},{"id":"GO:0072054","count":6}]},{"hash":"1049649173988061376","title":"Cell Cycle Regulation & Nuclear Import","description":"This cluster is driven by GO terms most tied to cell cycle control and chromatid cohesion (regulation of cell cycle; regulation of centromeric sister chromatid cohesion) and nuclear import (NLS-bearing protein import into the nucleus), suggesting a core theme around cell cycle progression and nuclear transport. The presence of broader development terms appears incidental or reflects pleiotropy across species, rather than a single cohesive developmental pathway. ","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":8},{"id":"GO:0070602","count":7},{"id":"GO:0071681","count":7},{"id":"GO:0048364","count":7},{"id":"GO:0022006","count":7}]},{"hash":"4501157130489874","title":"Developmental Signaling and Morphogenesis","description":"The GO terms point to broad developmental roles, including nervous system development, embryonic axis specification, and morphogenesis, complemented by signaling pathway activities (dopamine receptor signaling, prostaglandin response) and remodeling processes (molting/cuticle, proteolysis). This suggests a cohesive theme of development and tissue formation across species.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048484","count":2},{"id":"GO:0007191","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0043050","count":1}]},{"hash":"739228974303077246","title":"Organ and tissue development","description":"The items center on development and differentiation across various tissues and organs (nervous system, endocrine, placenta, heart, cartilage, pancreas). This points to a broad developmental theme rather than a single pathway, so \"Organ and tissue development\" captures the cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032287","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0060806","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0060536","count":1}]},{"hash":"1193609712890438524","title":"Neuronal excitability and sensory perception","description":"This cluster shows a common thread in nervous system function: sensory modalities (pain, vision) and terms tied to nervous system development, combined with ion transport and membrane potential regulation (sodium/potassium transport, membrane hyperpolarization). Together, these suggest proteins involved in neuronal signaling and excitability, rather than a single metabolic pathway. ","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0097623","count":3}]},{"hash":"1822057186326593567","title":"Neuronal chromatin regulation and spine morphogenesis","description":"This cluster centers on nuclear gene expression control (mRNA processing, regulation of transcription, histone modification) and includes neuronal morphology processes (dendritic spine morphogenesis, actin filament bundling). The convergence of chromatin-related terms with spine development hints at a theme where gene expression regulation interfaces with neuronal morphogenesis, even though the proteins show no observed interactions in this cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0021551","count":2},{"id":"GO:0006511","count":2}]},{"hash":"169597530933003691","title":"Skeletal muscle and bone differentiation regulation","description":"These proteins show enrichment in GO terms tied to differentiation of musculoskeletal lineages: skeletal muscle differentiation, osteoblast differentiation/ossification, and endothelial differentiation, with SMAD signaling regulation suggesting TGF-beta pathway involvement. There are also a few terms related to post-transcriptional regulation (translation control, poly(A) tail shortening) that may be secondary. Overall, the main theme appears to be regulation of differentiation across muscle, bone, and vascular contexts.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":2},{"id":"GO:0045668","count":1},{"id":"GO:0045603","count":1},{"id":"GO:0060212","count":1},{"id":"GO:0017148","count":1}]},{"hash":"193243724091716044","title":"Mitotic spindle and chromosome segregation regulation","description":"This cluster is dominated by terms tied to mitosis and chromosome handling: localization of the chromosome passenger complex to the spindle midzone, protein localization to kinetochores, and meiotic spindle disassembly, plus peptidyl-threonine dephosphorylation involved in mitotic control. Although a few terms touch on signaling pathways, the core pattern centers on spindle dynamics and chromosome segregation during cell division.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":8},{"id":"GO:0000200","count":8},{"id":"GO:0050860","count":8},{"id":"GO:0034501","count":7},{"id":"GO:0051229","count":7}]},{"hash":"2040449751360793911","title":"Mammalian reproductive and gland morphogenesis","description":"The cluster shows enrichment in blastocyst development, female pregnancy, mammary gland involution, and adenohypophysis morphogenesis, plus branching morphogenesis of vessels, indicating a cohesive theme of reproductive and gland development. Some terms are unrelated or obsolete (neuronal calcium regulation, methylmercury response), but the main terms support the label.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097274","count":4},{"id":"GO:0007565","count":3},{"id":"GO:0051597","count":3},{"id":"GO:0001824","count":3},{"id":"GO:0060056","count":2}]},{"hash":"2034731856251923457","title":"Vesicle trafficking and organelle inheritance","description":"The cluster\u2019s top GO terms cluster around intracellular transport and distribution of organelles (asymmetric Golgi ribbon formation, vesicle transport along actin, pigment granule transport) and inheritance of mitochondria and peroxisomes. Several terms also hint at muscle/cardiovascular contexts (muscle filament sliding, cardiac muscle development, VEGF signaling), which can depend on robust vesicle trafficking and organelle positioning. Taken together, the dominant theme is vesicle trafficking coupled with organelle inheritance, with a cardiovascular muscle context as a supporting angle.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090164","count":3},{"id":"GO:0030050","count":3},{"id":"GO:0051904","count":3},{"id":"GO:0030049","count":3},{"id":"GO:0045033","count":3}]},{"hash":"200616774412466072","title":"Developmental signaling across heart, vasculature, and brain","description":"The top GO terms point to broad developmental roles across multiple tissues\u2014heart, skeletal system, angiogenesis, forebrain development, and synapse assembly\u2014along with ERK/MAPK signaling and regulation of apoptosis and cell cycle. This pattern suggests a cluster of proteins coordinating developmental signaling and tissue formation across organs rather than a single tissue. The diverse yet connected terms support a coherent developmental theme, despite no interaction edges in the data.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0001501","count":5},{"id":"GO:0001525","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0043065","count":4}]},{"hash":"1257292716688739534","title":"DNA Replication and Cell Cycle Regulation","description":"The top GO terms cluster around DNA replication, centrosome cycle, and nuclear cell cycle regulation (with DNA repair), indicating a core theme of nuclear DNA synthesis and cell cycle control. A few terms about development and dopaminergic synaptic signaling appear as outliers.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007118","count":7},{"id":"GO:2000810","count":7},{"id":"GO:0090314","count":7},{"id":"GO:0007098","count":7},{"id":"GO:0010571","count":7}]},{"hash":"226280235394421223","title":"Neuronal development and synaptic signaling","description":"This cluster is enriched for nervous system development, dopaminergic neuron differentiation, neuron maturation regulation, and synaptic processes (modification of synaptic structure, endocytosis, GPCR signaling). The combination points to proteins involved in neural development and synaptic trafficking/signaling, with a couple of peripheral terms (phagophore-related localization and organ size regulation) that may reflect broader cellular processes accompanying neuronal differentiation. Overall, the dominant theme is neural development and synaptic function.","confidence":"Medium","size":8,"edges":9,"triangles":4,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0099563","count":8},{"id":"GO:0034497","count":8},{"id":"GO:0014041","count":8},{"id":"GO:0045792","count":8},{"id":"GO:0038027","count":8}]},{"hash":"507677124145330121","title":"TGF-beta Signaling Regulators","description":"The top GO terms point to modulation of TGF-beta signaling, including cellular responses to TGF-beta stimulus (GO:0071560), negative regulation of TGF-beta receptor signaling (GO:0030512), and SMAD-related assembly, along with a related emphasis on phosphatase activity (peptidyl-threonine dephosphorylation). There are also connections to broader signaling modulation (NF-kappaB, MAPK) and vesicle trafficking, which can intersect with TGF-beta pathway regulation. An outlier term related to photosystem stoichiometry adjustment suggests possible cross-species annotation noise, but the central theme remains TGF-beta pathway regulation and signal transduction. ","confidence":"Medium","size":8,"edges":10,"triangles":7,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046827","count":7},{"id":"GO:0071560","count":7},{"id":"GO:0042006","count":5},{"id":"GO:0030512","count":5},{"id":"GO:0080005","count":5}]},{"hash":"2069632167704040908","title":"Signaling Pathways and Receptor Trafficking","description":"The GO terms show a mix of signaling pathways (calcineurin-NFAT, KIT, Wnt/PCP, NMDA receptor clustering) and receptor handling processes (endocytosis), along with leukotriene biosynthesis. This pattern suggests proteins involved in diverse signaling and receptor regulation/trafficking rather than a single cohesive pathway, hence a broad \"signaling and receptor trafficking\" label.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":2},{"id":"GO:1903356","count":2},{"id":"GO:0097114","count":2},{"id":"GO:0038109","count":2},{"id":"GO:0019370","count":2}]},{"hash":"438504840586034537","title":"Unknown","description":"The top GO terms span sensory development (inner ear development, sensory perception of pain), transcriptional regulation (DNA-templated transcription), signaling (cGMP-related), ion transport (sodium import), development processes (multicellular organism development), and even immune response (defense against Gram-positive bacteria). Because these functions are broad and not clearly connected into a single coherent biological theme for this cluster, there isn\u2019t a reliable, concise label to reflect a unifying purpose.","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0006349","count":4},{"id":"GO:0046827","count":4},{"id":"GO:0048839","count":4}]},{"hash":"2262090683134403251","title":"Immune activation and vascular morphogenesis","description":"This cluster is enriched for immune-related GO terms: positive regulation of platelet activation, cellular response to fungal origin, dendritic cell apoptotic regulation, arachidonate secretion, cell adhesion molecule production, phagocytosis recognition, and complement activation. The presence of lymph vessel morphogenesis and metanephric tubule development terms are more about tissue remodeling but can accompany inflammatory responses. Overall, the dominant theme is immune activation and inflammatory signaling, with some vascular/tissue remodeling hints. ","confidence":"Medium","size":8,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":3},{"id":"GO:0071226","count":3},{"id":"GO:2000670","count":3},{"id":"GO:0090238","count":2},{"id":"GO:0060355","count":2}]},{"hash":"1671587057087930939","title":"Plant Meristem Signaling and Growth Regulation","description":"The cluster\u2019s GO terms cluster around regulation and modulation of signaling pathways (BMP/TGF-beta via SMAD, NF-kappaB, MAPK cascades) and their negative regulation, along with plant-specific processes like maintenance of meristem identity and photosystem adjustments. The inclusion of peptidyl-threonine dephosphorylation supports a focus on phosphorylation-dependent signaling control. Together, these terms suggest a theme of coordinating growth and developmental signaling in plants, with some cross-talk to general signaling pathways.","confidence":"Medium","size":8,"edges":8,"triangles":3,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046827","count":5},{"id":"GO:0071560","count":5},{"id":"GO:0035970","count":4},{"id":"GO:0000173","count":4},{"id":"GO:0010991","count":4}]},{"hash":"1680801709102092234","title":"Neural development and NMJ assembly","description":"Dominant GO terms center on nervous system development and synaptic assembly at the neuromuscular junction, with supporting signals for neural circuitry\u2013related behaviors (locomotion, mating) and calcium signaling, plus some RNA processing terms. This points to a cohesive theme of neural development and NMJ formation, with ancillary roles in gene expression regulation.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2},{"id":"GO:1905945","count":1},{"id":"GO:0051563","count":1}]},{"hash":"1105645166188272516","title":"NFAT signaling regulation and ubiquitin-mediated processing","description":"The top GO terms cluster around regulation of the calcineurin-NFAT signaling cascade, along with ubiquitin-related processes (ubiquitination, ERAD) and dephosphorylation, suggesting a common theme of post-translational control of signaling. Additional terms point to broader immune signaling modulation (TLR3, B cell homeostasis) and xenobiotic response, indicating a suite of proteins involved in signaling regulation and protein turnover rather than a single specific function.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051533","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1640432032587796048","title":"RNA processing and translation initiation","description":"The top GO terms cluster around mRNA splicing and processing (alternative splicing, splice site recognition, spliceosome, mRNA modification, mRNA stabilization) and the assembly/formation of translation initiation machinery (preinitiation complex, eIF4F complex). These co-occurence suggest a functional module focused on post-transcriptional mRNA handling and initiation of translation, with one outlier term related to actin filament assembly that may be incidental. Confidence: Medium.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":2},{"id":"GO:0016556","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0097010","count":2},{"id":"GO:1902625","count":2}]},{"hash":"932747206162327795","title":"Mitochondrial protein import and inner membrane insertion","description":"The top GO terms are dominated by mitochondrial import-related processes (e.g., GO:0030150, GO:0045039), indicating proteins involved in targeting and inserting proteins into the mitochondrial matrix/internal membrane. While a chloroplast import term and some trafficking-related terms appear, the mitochondrial import signal is strongest, suggesting the cluster centers on mitochondrial protein targeting and assembly.","confidence":"High","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":4},{"id":"GO:0045039","count":3},{"id":"GO:0030150","count":3},{"id":"GO:0032094","count":2},{"id":"GO:0045037","count":2}]},{"hash":"64115255132753807","title":"Organ development and inflammatory signaling","description":"GO terms suggest a theme of tissue/organ development (heart, lung connective tissue, nipple morphogenesis, ovarian follicle growth) combined with regulation of signaling pathways (ERK cascade, NF-kappaB, IP3 biosynthesis, adenylate cyclase activity) and inflammatory response, indicating a cluster of developmental signaling linked to inflammation.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0051092","count":2},{"id":"GO:0032962","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0060427","count":2}]},{"hash":"1769747829285332947","title":"Embryonic development and tissue morphogenesis","description":"Coherent set of GO terms points to developmental differentiation and tissue morphogenesis, especially embryonic/placental contexts (placental development, trophoblast differentiation, left/right patterning, cartilage morphogenesis, pancreatic cell development, endocardial EMT, endocrine system development). A translation term and a couple of stress-response terms appear as general cellular processes rather than central themes. Overall, the proteins likely participate in embryogenesis and organ/tissue morphogenesis.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0003198","count":5}]},{"hash":"552512331670505000","title":"Developmental morphogenesis and organogenesis","description":"The dominant GO terms span development across multiple organs and tissues (reproductive ducts, kidney morphogenesis, heart differentiation, neural axon growth) along with tissue architecture (cell\u2013cell junctions). Regulatory processes such as NFAT signaling and miRNA silencing are also present, suggesting a broad theme of embryonic development and organogenesis rather than a single pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061205","count":4},{"id":"GO:0045216","count":4},{"id":"GO:0072283","count":4},{"id":"GO:0055011","count":4},{"id":"GO:0046013","count":4}]},{"hash":"15928525831711943","title":"RNA silencing machinery (miRNA/siRNA)","description":"Based on the strong enrichment of RNA interference-related terms\u2014primary miRNA processing, siRNA processing, RISC complex assembly, and related RNA processing steps\u2014the cluster appears to represent components of the RNA silencing pathway (miRNA/siRNA biogenesis and RISC function). A few other terms (e.g., dosage compensation, spinal cord morphogenesis) seem less connected and may be noise. ","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031053","count":3},{"id":"GO:0030422","count":3},{"id":"GO:0045071","count":2},{"id":"GO:0009047","count":2},{"id":"GO:0035087","count":2}]},{"hash":"2017669193717594556","title":"Mitotic cell cycle and actin cytoskeleton remodeling","description":"The cluster\u2019s GO terms mainly point to mitosis (cell division, mitotic cell cycle, G2/M transition) and to actin cytoskeleton organization and lamellipodium formation, suggesting a coordinated role in cell division that involves remodeling of the actin cytoskeleton. The combination of cell-cycle progression signals with cytoskeletal dynamics supports a cohesive functional theme for these proteins.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0045792","count":1},{"id":"GO:1905287","count":1},{"id":"GO:0048255","count":1},{"id":"GO:0000278","count":1}]},{"hash":"368717725351730973","title":"Fatty acid biosynthesis and lipid metabolism","description":"This cluster is dominated by GO terms tied to lipid production and processing, including fatty acid biosynthetic process, long- and medium-chain fatty-acyl-CoA metabolism, and lipoteichoic acid biosynthetic process, suggesting a cohesive lipid metabolism module. Several terms reflect acetyl-CoA\u2013linked steps, reinforcing a common metabolic theme around lipid construction and modification. A couple of outliers (seed coat development, siderophore biosynthesis) are less directly connected but may reflect broader secondary metabolism contexts in some organisms.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":5},{"id":"GO:0019654","count":5},{"id":"GO:1902987","count":5},{"id":"GO:0010214","count":5},{"id":"GO:0070395","count":5}]},{"hash":"1653111211449657764","title":"Neuronal axon guidance and synaptic vesicle regulation","description":"Most enriched GO terms cluster around neural development and axon guidance, including positive regulation of axon extension, axon guidance, paranode localization, and regulation of synaptic vesicle endocytosis, with supporting terms for ganglion development. This suggests a neuronal development/axon-trajectory-focused group rather than unrelated processes.","confidence":"High","size":8,"edges":6,"triangles":4,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048842","count":4},{"id":"GO:1900242","count":4},{"id":"GO:0060982","count":4},{"id":"GO:0090091","count":3},{"id":"GO:1902946","count":3}]},{"hash":"164518912840503440","title":"Chromatin organization and cell cycle transcription control","description":"Most top terms point to chromatin organization and transcriptional regulation during the cell cycle: sister chromatid cohesion; subtelomeric and rDNA heterochromatin formation; regulation of transcription involved in G1/S and G2/M transitions; and nucleosome density. Although a couple of terms touch on metabolism (acetoin) and calcium signaling, these appear as ancillary annotations rather than core cluster themes. Overall, the proteins seem linked to chromatin dynamics and cell-cycle\u2013driven transcription.","confidence":"Medium","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000117","count":6},{"id":"GO:0045149","count":6},{"id":"GO:0060303","count":6},{"id":"GO:0010882","count":6},{"id":"GO:0000083","count":6}]},{"hash":"1022105222147778337","title":"Autophagy and ER membrane trafficking","description":"The cluster is dominated by autophagy-related terms (mitophagy, aggrephagy, and regulation of intralumenal vesicle formation) and by membrane/ER-associated processes (tail-anchored membrane protein insertion into the ER membrane) and protein processing, pointing to a cohesive theme of proteostasis, organelle turnover, and vesicle/membrane trafficking. Some terms like transcription regulation by RNA Pol II are less directly linked, so the overall label reflects the strongest shared signal.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006357","count":7},{"id":"GO:0010637","count":7},{"id":"GO:0000423","count":7},{"id":"GO:0035973","count":7},{"id":"GO:0002109","count":7}]},{"hash":"153573411385284100","title":"Ubiquitin-Dependent Degradation and ERAD","description":"Major terms cluster around ubiquitin-mediated regulation: protein ubiquitination, autoubiquitination, and ubiquitin-dependent protein catabolic process, plus the ERAD pathway term, indicating involvement in endoplasmic reticulum-associated degradation. Sumoylation also appears, suggesting broader post-translational modification context. A couple of terms about translation and DNA repair are less central, likely reflecting shared components rather than primary function. Overall, the proteins appear to participate in ubiquitin-system\u2013driven protein turnover, especially ERAD.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0042787","count":3}]},{"hash":"1147781883505668058","title":"Lipid and steroid hormone biosynthesis","description":"The top GO terms cluster around biosynthetic processes for lipid- and steroid-derived signaling molecules (prostaglandins, ecdysone, progesterone, bile acids) and related retinoic acid metabolism. A couple of environmental-response terms are present but secondary. This suggests the proteins collectively participate in lipid/hormone biosynthesis and metabolism rather than a single, narrow function.","confidence":"Medium","size":8,"edges":11,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":5},{"id":"GO:0033068","count":4},{"id":"GO:0006697","count":4},{"id":"GO:0042448","count":4},{"id":"GO:0010193","count":4}]},{"hash":"355963785276541037","title":"RNA transcription and processing","description":"The proteins appear linked to multiple RNA transcription-related processes across RNA polymerases I\u2013III (Pol I rRNA, Pol II transcription initiation, Pol III tRNA transcription) and RNA-templated transcription, plus RNA splicing and regulation of mRNA tail shortening, indicating a broad role in RNA transcription and processing rather than a single specific pathway. Some terms (e.g., apoptotic process) may be less directly connected or reflect annotation noise. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097394","count":1},{"id":"GO:0006367","count":1},{"id":"GO:0042790","count":1},{"id":"GO:0010590","count":1},{"id":"GO:0042797","count":1}]},{"hash":"898183329799992507","title":"Unknown","description":"The listed GO terms span very different biological areas\u2014including ribosome biogenesis, ubiquitination, transcription regulation, signaling, adaptive immune response, cell cycle, septum assembly, iron transport, and salt-stress response\u2014without a single cohesive function linking them. This diversity suggests no clear shared theme for the cluster.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000747","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0046328","count":2}]},{"hash":"320230682191937077","title":"Neuronal vesicle trafficking and synaptic exocytosis","description":"The top GO terms cluster around neurotransmitter release and vesicle cycling (positive regulation of norepinephrine secretion, vesicle fusion with vacuole, regulation of synaptic vesicle priming, synaptic vesicle recycling, exocytic insertion of neurotransmitter receptors, long-term potentiation), as well as Golgi- and vesicle-trafficking processes (intra-Golgi vesicle-mediated transport, Golgi ribbon formation). While a non-neuronal term appears, the overall pattern points to vesicle trafficking and synaptic signaling in neurons.","confidence":"High","size":8,"edges":17,"triangles":10,"max_degree":7,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0010701","count":5},{"id":"GO:0051469","count":5},{"id":"GO:1903422","count":5},{"id":"GO:0006675","count":5},{"id":"GO:0010807","count":5}]},{"hash":"574690612601297758","title":"Ubiquitin-mediated NF-kappaB signaling in adaptive immunity","description":"The top GO terms show adaptive immune response and various ubiquitination-related processes (K48- and K6-linked ubiquitination, ubiquitin-dependent protein turnover) with regulation of I-kappaB phosphorylation, pointing to NF-kappaB pathway control in immune signaling.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0042787","count":5},{"id":"GO:1900095","count":4}]},{"hash":"1872394444833589125","title":"TLR/MyD88-driven Cytokine Signaling with Actin Remodeling","description":"The terms point to innate immune activation via MyD88-dependent TLR signaling, supporting production of IL-6 and IL-18 and responses to muramyl dipeptide, with additional enrichment for actin cytoskeleton remodeling (actin filament formation, barbed-end uncapping). Some terms (RNA import, cornea development) are peripheral, but the core theme is immune signaling coupled with cytoskeletal dynamics.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0031146","count":5},{"id":"GO:0051639","count":4},{"id":"GO:0032741","count":4},{"id":"GO:0032755","count":4},{"id":"GO:0002755","count":4}]},{"hash":"469175401292251810","title":"Male reproductive development and steroid signaling","description":"The top terms cluster around male reproductive biology: male sex differentiation, prostate gland development, and steroid hormone receptor complex assembly, suggesting a theme linked to male development and hormone signaling. While a few other terms touch on metabolism or general cellular processes, the strongest shared function across the terms is related to reproductive development and hormone receptor activity.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0046661","count":2},{"id":"GO:0030850","count":2},{"id":"GO:0006463","count":2},{"id":"GO:0051301","count":2}]},{"hash":"239849758325140932","title":"Developmental Transcription and Tissue Differentiation","description":"This cluster centers on multicellular development and tissue differentiation, with DNA-templated transcription as a core process and terms for skeletal system development, myoblast fusion, brain development, and lens fiber differentiation. The shared themes suggest proteins involved in developmental gene regulation across multiple tissues, indicating a developmental transcriptional program rather than a single pathway.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0000747","count":2}]},{"hash":"1730710604250859578","title":"Plant Cell Wall Biosynthesis and Glycosylation","description":"Most of the top GO terms point to plant-specific processes: cell wall organization, cellulose biosynthesis, glucuronoxylan biosynthesis, and plant-type secondary cell wall biogenesis, along with protein glycosylation pathways. These collectively suggest a cluster driven by plant cell wall construction and glycosylation activities. Some terms (e.g., retina development, diet-induced thermogenesis)appear as outliers, but the dominant signal is plant cell wall formation and glycosylation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016266","count":3},{"id":"GO:0071555","count":3},{"id":"GO:0060041","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0006486","count":2}]},{"hash":"421064539347219972","title":"Neural development and axonogenesis","description":"These proteins are linked to nervous system development and axon growth, including neurogenesis, axonogenesis, photoreceptor differentiation, dendrite self-avoidance, interneuron migration cues, and axon regeneration, with supporting terms for paranode localization and connective tissue context. This suggests a cohesive theme around neural development and axon pathfinding, despite a couple of broader tissue-associated terms. ","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001751","count":5},{"id":"GO:0070593","count":5},{"id":"GO:0021836","count":5},{"id":"GO:1904238","count":5},{"id":"GO:0042698","count":5}]},{"hash":"252969825734255252","title":"Mitochondrial Metabolite Transport","description":"The GO terms point to transmembrane transport of a variety of metabolites and cofactors (deoxynucleotides, coenzyme A, thiamine pyrophosphate, ADP/ATP, glycine, manganese ions) with a strong emphasis on mitochondrial processes, plus related regulation of mitochondrial membrane potential and oxidative stress response (superoxide). This suggests a cohesive theme of mitochondrial metabolite transport and energy/homeostasis regulation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030302","count":4},{"id":"GO:0097274","count":4},{"id":"GO:0035349","count":4},{"id":"GO:0051881","count":4},{"id":"GO:0000303","count":4}]},{"hash":"738198033361854675","title":"Developmental morphogenesis and cell adhesion","description":"The proteins show enrichment across organ morphogenesis (brain, kidney, heart) and neural differentiation, plus cell\u2013cell junctions (desmosomes, cardiac cell\u2013cell adhesion) and cytoskeletal assembly, suggesting a cohesive theme of tissue development and connectivity.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":6},{"id":"GO:0021550","count":5},{"id":"GO:0003338","count":5},{"id":"GO:0086073","count":5},{"id":"GO:0071255","count":5}]},{"hash":"522559550179058107","title":"Mitotic spindle and chromosome segregation with cell cycle control","description":"The cluster\u2019s top GO terms center on mitosis-related processes (mitotic spindle assembly, chromosome segregation, regulation of exit from mitosis, and cytokinesis) and broader cell cycle regulation, suggesting these proteins mainly participate in cell-division machinery. A translation term appears but is less central, so the overall theme reflects mitosis/cell-cycle control.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0051311","count":1},{"id":"GO:0071157","count":1},{"id":"GO:0031536","count":1}]},{"hash":"1811180307095237073","title":"RNA processing and P-body/stress granule assembly","description":"The top GO terms point to mRNA processing, deadenylation-dependent decay, and the assembly of RNA granules (P-bodies and stress granules), with additional notes on heat response. This suggests a cluster centered on post-transcriptional regulation and RNA storage/decay under stress, rather than a single metabolic pathway. Minor terms related to spindle or inflammatory responses appear as secondary associations. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0060213","count":1},{"id":"GO:0045663","count":1}]},{"hash":"283125901108565770","title":"Inflammation-driven EMT and ECM remodeling","description":"The dominant GO terms cluster around inflammatory responses (acute inflammatory response, cytokine production), epithelial-to-mesenchymal transition (EMT), and basement membrane disassembly, pointing to inflammation-associated tissue remodeling and potential cancer invasion processes. Some terms (glucose catabolic process, chloroplast targeting) seem like noise or incidental annotations, but the core signal supports inflammatory signaling and ECM remodeling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039707","count":3},{"id":"GO:0006007","count":3},{"id":"GO:0045036","count":3},{"id":"GO:0030307","count":2},{"id":"GO:0043277","count":2}]},{"hash":"158711955090165549","title":"Calcium and Ion Signaling in Metabolic Regulation","description":"These proteins show enrichment for ion-related and metabolic signaling terms, including potassium ion transport, calcium ion response, and thermogenesis/brown fat differentiation, suggesting a theme of ion-driven regulation of energy metabolism. Additional terms around Rho signaling, cold response, and endothelial cell changes point to broader cellular signaling dynamics that can modulate metabolic processes. Some terms (cerebellum maturation, flagellated sperm motility) are less clearly tied to metabolism and may reflect broader annotation or multifunctionality. Overall, the cluster appears to be centered on ion signaling linked to metabolic regulation, with variable alignment among the listed terms.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0006813","count":7},{"id":"GO:0021590","count":6},{"id":"GO:0009409","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0030317","count":6}]},{"hash":"712641446980993364","title":"Cell Stress, Inflammation, and Development","description":"This cluster combines stress-related responses (unfolded protein response, calcium signaling) with inflammatory signaling and multiple developmental/remodeling processes (bone maturation, kidney development, axon guidance, fibroblast migration, peptide cross-linking, and related tissue remodeling). The unifying theme is stress-activated signaling linked to tissue development and remodeling, rather than a single specific pathway.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006986","count":6},{"id":"GO:0051592","count":5},{"id":"GO:0002544","count":5},{"id":"GO:0072221","count":5},{"id":"GO:0043931","count":5}]},{"hash":"341097596901735543","title":"Mitochondrial and metabolite membrane transport","description":"This cluster centers on diverse transmembrane transport activities (deoxynucleotide, CoA, ADP, TPP, glycine, Mn ions) and mitochondrial ATP transport, along with regulation of mitochondrial membrane potential and oxidative stress response. The shared theme is membrane transport of metabolites/ions with a mitochondrial functional context, justifying the label. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030302","count":8},{"id":"GO:0097274","count":8},{"id":"GO:0035349","count":8},{"id":"GO:0051881","count":8},{"id":"GO:0000303","count":8}]},{"hash":"841112747440801779","title":"Cold-triggered thermogenesis and metabolic stress","description":"This cluster is dominated by terms related to cold response and brown fat differentiation, pointing to thermogenesis and energy metabolism. Additional terms touch on stress and signaling (apoptosis, endothelial remodeling, proteasome assembly, NOD1 signaling), suggesting a broad stress-metabolism theme rather than a single cohesive pathway. The heterogeneity and lack of direct interactions imply a best-fit label with moderate confidence.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009409","count":8},{"id":"GO:0070427","count":8},{"id":"GO:0097284","count":8},{"id":"GO:0043488","count":8},{"id":"GO:0097497","count":8}]},{"hash":"884298456143326639","title":"Vascular remodeling and EMT signaling","description":"The GO terms show emphasis on blood vessel branching, lymphangiogenesis, and epithelial-to-mesenchymal transition, pointing to vascular development and cell-state changes as the core theme. Additional signals like NFAT/calcium regulation hint at broader signaling pathways involved in these processes, while some terms (RNA Pol II regulation, kinetochore localization) are more general. Overall, the cluster centers on signaling and remodeling in vascular/EMT contexts.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070940","count":7},{"id":"GO:0034501","count":7},{"id":"GO:0001569","count":7},{"id":"GO:0001946","count":7},{"id":"GO:0051531","count":7}]},{"hash":"335449591541671582","title":"Mitotic spindle dynamics and chromosome alignment","description":"The top GO terms are strongly focused on mitosis and microtubule-associated processes: metaphase chromosome alignment, spindle midzone assembly, kinetochore-mubule attachment, and various microtubule depolymerization steps, signaling a cohesive role in spindle function and chromosome segregation. A couple of developmental terms appear less central but do not outweigh the spindle-centric signals. Overall, the cluster appears to group proteins involved in mitotic spindle dynamics and chromosome alignment.","confidence":"High","size":7,"edges":13,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":5},{"id":"GO:0036334","count":3},{"id":"GO:0048364","count":3},{"id":"GO:0007080","count":3},{"id":"GO:0010938","count":3}]},{"hash":"1649874355209243235","title":"Calcium-Driven Signaling in Development and Cell Cycle","description":"The cluster features several GO terms tied to calcium signaling and calcium-regulated pathways (cellular response to calcium, regulation of postsynaptic calcium, regulation of calcineurin-NFAT signaling) and kinase activity, along with processes related to development and cell division (blood vessel morphogenesis, epithelial-to-mesenchymal transition, cytokinesis, spindle pole body duplication). This suggests a common theme where calcium-dependent signaling modulates development and cell cycle transitions, justifying a label focusing on calcium-driven signaling in these contexts.","confidence":"Medium","size":7,"edges":14,"triangles":16,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042994","count":6},{"id":"GO:0001569","count":6},{"id":"GO:0050665","count":6},{"id":"GO:0051531","count":6},{"id":"GO:0099566","count":6}]},{"hash":"1536250909543592345","title":"Retroviral life cycle and assembly","description":"The top GO terms cluster around stages of retroviral infection and replication\u2014latency establishment, entry into the host, virion assembly, viral release, and RNA-templated DNA biosynthesis (reverse transcription)\u2014which together define the viral life cycle; additional terms like mRNA splicing and protein folding reflect host processes co-opted during replication, supporting a cohesive retroviral replication theme.","confidence":"High","size":7,"edges":9,"triangles":4,"max_degree":4,"top_function":"protein folding","top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0030260","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0019076","count":4},{"id":"GO:0019068","count":4}]},{"hash":"866597487955318930","title":"Chromatin Regulation and Cell Cycle Control","description":"The top GO terms cluster around chromatin organization (nucleosome regulation, heterochromatin formation, rDNA heterochromatin) and cell-cycle\u2013related transcription regulation (G1/S and G2/M transitions, sister chromatid cohesion), suggesting a cohesive theme of chromatin remodeling coupled to cell cycle control. A few outliers (acetoin metabolism, cardiac calcium signaling, androgen receptor signaling) are present but do not disrupt the core chromatin/cell-cycle signal.","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000117","count":7},{"id":"GO:0045149","count":7},{"id":"GO:0060303","count":7},{"id":"GO:0010882","count":7},{"id":"GO:0000083","count":7}]},{"hash":"1307732583479857434","title":"Astrocyte Differentiation and Calcium Signaling","description":"This cluster shows a clear emphasis on astrocyte differentiation and calcium-dependent signaling, with GO terms for regulating postsynaptic calcium, cellular calcium response, and regulation of calcineurin-NFAT signaling. Additional morphogenesis terms (EMT, vascular branching, pituitary morphogenesis) suggest a broader developmental program, but the strongest cohesive signal centers on glial lineage specification and calcium-driven transcriptional regulation. ","confidence":"Medium","size":7,"edges":17,"triangles":21,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042994","count":6},{"id":"GO:0048855","count":6},{"id":"GO:0001569","count":6},{"id":"GO:0099566","count":6},{"id":"GO:0051531","count":6}]},{"hash":"7466878328884955","title":"Actin dynamics and junctions","description":"This cluster's GO terms cluster around actin-based structures and membrane remodeling: filopodium and podosome assembly; endocytosis and engulfment of apoptotic cells; bicellular tight junction assembly; and GTPase regulation, along with signaling pathways like EGFR and Wnt that commonly regulate the cytoskeleton and adhesion. Together these terms suggest a coherent theme of cytoskeletal remodeling driving adhesion, membrane trafficking, and signal coordination.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070830","count":6},{"id":"GO:0006897","count":5},{"id":"GO:0071803","count":5},{"id":"GO:0007173","count":5},{"id":"GO:0043652","count":5}]},{"hash":"748043306400594822","title":"Quinone biosynthesis and redox metabolism","description":"The cluster shows strong enrichment for quinone biosynthesis (menaquinone and phylloquinone) alongside fatty acid oxidation and various catabolic pathways, with additional redox-related terms (redox homeostasis, oxidative stress). This pattern suggests a cohesive theme around redox-balanced energy metabolism centered on quinone biosynthesis, making the label representative of the cluster\u2019s function.","confidence":"Medium","size":7,"edges":16,"triangles":17,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0009234","count":4},{"id":"GO:0010124","count":4},{"id":"GO:0006635","count":4},{"id":"GO:0042372","count":4}]},{"hash":"250362219092209006","title":"Amino acid and neurotransmitter transport","description":"This cluster is dominated by GO terms for transporting amino acids (serine, threonine, glutamate, D-aspartate) across membranes and general transmembrane transport, with additional links to neurotransmitter-related processes (GABA biosynthesis and dopaminergic synaptic transmission). Together these suggest a group of proteins functioning primarily as amino acid/neurotransmitter transporters.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0032329","count":5},{"id":"GO:0070779","count":5},{"id":"GO:0055085","count":5},{"id":"GO:0015826","count":5},{"id":"GO:0051938","count":5}]},{"hash":"1777484501911097391","title":"Membrane Transporters (Ions, Sugars, Neurotransmitters)","description":"These proteins cluster around membrane transport activities across a variety of substrates, including ions (sodium, potassium, phosphate), sugars (arabinose, galactose), and vesicular processes such as neurotransmitter loading into synaptic vesicles. The shared theme is transmembrane transport rather than a single enzymatic function, making a concise label like \u201cMembrane Transporters (Ions, Sugars, Neurotransmitters)\u201d descriptive and representative.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0071805","count":3}]},{"hash":"2267371674432050052","title":"Nervous system development and dendrite morphogenesis","description":"The top GO terms are dominated by neural development processes: nervous system development, CNS neuron development, and dendrite morphogenesis, suggesting the proteins cluster around neural differentiation and neuron morphology. While there are also general transcription/translation terms, they do not define the primary theme, so a neural development-focused label best represents the cluster\u2019s shared function.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0071226","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006353","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2276307040093918507","title":"Translation machinery and regulation","description":"Most of the top GO terms describe steps of protein synthesis and ribosome function, including mitochondrial translational elongation, cytoplasmic translation initiation/termination, and ribosome disassembly. Additional terms cover translational fidelity and selenocysteine incorporation, and the association with mRNA decay links translation efficiency to mRNA turnover. Together these indicate a cluster of proteins involved in assembling and regulating the ribosome and translation in both mitochondria and cytoplasm.","confidence":"High","size":7,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070125","count":3},{"id":"GO:2000767","count":3},{"id":"GO:0002184","count":3},{"id":"GO:1902802","count":3},{"id":"GO:0032790","count":3}]},{"hash":"2195747203587529307","title":"Unknown","description":"The terms are scattered across diverse biological processes (acetylation, hormone/insulin metabolism, pheromone maturation, PQQ biosynthesis, ubiquitin recycling, lifespan determination, oligomerization, viral processes), with no single dominant function or shared pathway, so no cohesive cluster label can be assigned.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017196","count":1},{"id":"GO:1901143","count":1},{"id":"GO:0071432","count":1},{"id":"GO:0018189","count":1},{"id":"GO:0010992","count":1}]},{"hash":"1183955805324112184","title":"Unknown","description":"The top GO terms span mitochondrial energy metabolism, general translation, RNA splicing regulation, and several vesicle trafficking processes (endocytosis and multivesicular body sorting), plus a gastric acid secretion regulator. This diversity offers no single cohesive function linking the proteins, so a precise label isn\u2019t discernible.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0042773","count":1},{"id":"GO:0006120","count":1},{"id":"GO:0032511","count":1}]},{"hash":"821728425517904299","title":"Developmental Transcriptional Regulation and Differentiation","description":"The cluster centers on DNA-templated transcription and regulation of developmental programs, including stem cell proliferation, embryonic development, and differentiation into neural and hematopoietic lineages (granulocytes, erythrocytes). Additional terms point to adipose tissue development, miRNA transcription, and lipopolysaccharide response, suggesting a network of transcriptional regulators coordinating development, lineage specification, and environmental signaling. The presence of tRNA wobble modification hints at broader RNA processing/translation regulation that may accompany these transcriptional programs. Confidence: Medium","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:2000648","count":2},{"id":"GO:1904179","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0030851","count":2}]},{"hash":"761343531065870212","title":"B cell receptor signaling and adaptive immunity","description":"This cluster is dominated by GO terms related to B cell receptor signaling (GO:0050853), follicular B cell differentiation, and the broader adaptive immune response, indicating a cohesive theme around B cell\u2013mediated immunity. Supporting terms about regulation of signaling pathways (Rho/Ras) and IP3 biosynthesis suggest associated intracellular signaling events that accompany B cell activation. Overall, the terms point to a focused immune function rather than general cellular processes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0009395","count":4},{"id":"GO:0002316","count":4},{"id":"GO:0046580","count":4}]},{"hash":"1321243348470472256","title":"Diverse Transmembrane Transporters","description":"This cluster shows strong enrichment for transmembrane transport GO terms across many substrates, from inorganic ions (K+, Na+, phosphate, nitrite) to organic compounds (nitrate, arabinose, vitamins, xenobiotics) and specific metabolites (4-hydroxyphenylacetate), suggesting that the proteins are membrane transporters with broad substrate specificities.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0006855","count":2},{"id":"GO:1900754","count":2}]},{"hash":"2187813441263169386","title":"mRNA Processing and Translation Initiation","description":"The GO terms center on mRNA modification and splicing (mRNA splice site recognition, alternative splicing, mRNA stabilization) together with translation initiation (formation of translation preinitiation complex, eIF4F complex assembly, translation reinitiation). This suggests the proteins act in RNA maturation and in priming transcripts for translation, i.e., a set of factors coordinating mRNA processing with initiation of protein synthesis.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0016556","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0097010","count":7},{"id":"GO:1902625","count":7},{"id":"GO:1905663","count":7}]},{"hash":"2185207454526385455","title":"Steroid Hormone and Retinoid Lipid Metabolism","description":"The cluster is strongly enriched for C21-steroid hormone metabolic processes, estrogen biosynthesis, retinoic acid/retinal metabolism, and sphingolipid biosynthesis, pointing to a cohesive theme of lipid-derived signaling molecules and vitamin A pathways. Some terms relating to antibiotic biosynthesis/response appear as noise, but the lipid/hormone metabolism signals dominate.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0042574","count":2},{"id":"GO:0008207","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0030148","count":2}]},{"hash":"1953292652287807901","title":"Rac-Driven actin remodeling and synaptic plasticity","description":"The top terms point strongly to Rac signaling driving actin cytoskeleton remodeling (Rac pathway, Arp2/3 nucleation, lamellipodium morphogenesis) with associated endocytosis and adhesion-related processes, plus components of synaptic plasticity (long-term depression, synapse structure). This suggests a cohesive theme of Rac-mediated cytoskeletal dynamics coordinating cell adhesion and synaptic remodeling. ","confidence":"High","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016601","count":3},{"id":"GO:1900026","count":2},{"id":"GO:0072673","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0070830","count":2}]},{"hash":"1826355045796061856","title":"Embryonic tissue differentiation across tissues","description":"The top GO terms converge on development and differentiation of multiple tissues (heart and Purkinje neuron lineages, peripheral nervous system neurons, and paramesonephric duct), with supporting processes like cell adhesion (adherens junction) and cytoskeletal signaling (Rho). Some entries are obsolete, but overall the cluster reflects embryonic morphogenesis and tissue-specific differentiation.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0061205","count":5},{"id":"GO:0032416","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0055011","count":5},{"id":"GO:0048936","count":5}]},{"hash":"1746528475613417899","title":"Amino acid biosynthesis and metabolism","description":"Based on the frequent GO terms, most entries relate to synthesis or breakdown of amino acids (alanine, aspartate, tyrosine) and related metabolic processes (biotin biosynthesis, fatty acid homeostasis). Notch signaling appears as a minor outlier, suggesting the core cluster centers on amino acid metabolism rather than a single signaling pathway.","confidence":"Medium","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":5},{"id":"GO:0007219","count":4},{"id":"GO:0042853","count":4},{"id":"GO:0097053","count":4},{"id":"GO:0006532","count":3}]},{"hash":"2297145454141668765","title":"Immune signaling and antigen presentation","description":"Based on the GO terms, several proteins cluster around adaptive immune signaling and antigen processing/presentation (T cell receptor signaling, Fc-epsilon receptor signaling, TNF signaling, MHC class I antigen presentation). This suggests the group is enriched for proteins involved in immune communication and antigen handling. Some terms are less directly connected (erythrocyte maturation, plant hypersensitive response, Wnt signaling, proteasomal degradation), but they do not override the core immune-related theme.","confidence":"Medium","size":7,"edges":9,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043249","count":2},{"id":"GO:0043488","count":1},{"id":"GO:0010363","count":1},{"id":"GO:0038095","count":1},{"id":"GO:0002479","count":1}]},{"hash":"181882105712635552","title":"Developmental gene regulation and morphogenesis","description":"The proteins show a broad enrichment for developmental and morphogenetic processes across multiple tissues (mammary glands, Leydig/prostate, hindlimb, habenula, heart outflow tract) along with transcriptional regulation terms (DNA-templated transcription, negative regulation of transcription by RNA polymerase II), suggesting a cluster of factors coordinating gene expression during development and organ formation rather than a single tissue-specific function.","confidence":"Medium","size":7,"edges":15,"triangles":11,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060749","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0033327","count":5},{"id":"GO:0000122","count":4},{"id":"GO:2000288","count":3}]},{"hash":"224612014122793640","title":"Broad differentiation and development regulation","description":"Top terms cluster around regulation or promotion of differentiation across multiple lineages (GABAergic neuron differentiation; cardioblast/heart field development; erythrocyte development; adipocyte differentiation) and broader developmental processes, with additional immune/endocrine signals (interferon response, IL-5 production, thyroid hormone generation). This suggests a theme of cell fate and developmental program regulation rather than a single coherent pathway.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097154","count":7},{"id":"GO:0035457","count":7},{"id":"GO:0051891","count":7},{"id":"GO:0072107","count":7},{"id":"GO:2000664","count":7}]},{"hash":"1677538465671163314","title":"Unknown","description":"The GO terms span chromatin-related processes (subtelomeric heterochromatin formation; histone H4 acetylation), multiple metabolism and biosynthesis pathways (N-acetylglucosamine metabolism; mycothiol; arginine biosynthesis; putrescine and acetoin catabolism; melatonin biosynthesis; N-terminal methionine acetylation), and plant-specific development (regulation of leaf formation). These are disparate across kingdoms and contexts, with no single cohesive function uniting all proteins, so a concise, representative label cannot be confidently assigned.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":7},{"id":"GO:0006044","count":6},{"id":"GO:0010125","count":6},{"id":"GO:0017196","count":6},{"id":"GO:0009447","count":6}]},{"hash":"679227369468143725","title":"Ubiquitin-Proteasome\u2013Mediated Protein Degradation & DNA Repair","description":"The Top Terms show strong enrichment for ubiquitin-dependent protein catabolic processes and proteasome-mediated degradation, including deubiquitination activities, which indicates a cluster focused on protein turnover and quality control. The presence of DNA repair and histone deubiquitination terms suggests a link between proteostasis and genome maintenance, with some additional hints of RNA processing and ER stress responses, but the dominant theme is ubiquitin-proteasome\u2013driven degradation connected to DNA repair.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0035522","count":2},{"id":"GO:0071108","count":2},{"id":"GO:0043161","count":2}]},{"hash":"2111553884037690697","title":"Neural development and axonogenesis","description":"Most of the top GO terms point to neuronal development and axon growth (neurogenesis, axonogenesis, peripheral nervous system axon regeneration, dendrite self-avoidance, chemorepulsion, and paranode localization), suggesting the cluster comprises proteins involved in neural differentiation and axon guidance. A few terms refer to non-neural processes (collagen fibril organization, pericyte differentiation, ovulation cycle) that may reflect broader tissue context or annotation noise, but do not override the dominant neural signal.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001751","count":3},{"id":"GO:0070593","count":3},{"id":"GO:0021836","count":3},{"id":"GO:1904238","count":3},{"id":"GO:0042698","count":3}]},{"hash":"730764704664011365","title":"Acetylation-Linked Metabolism and Chromatin Regulation","description":"Several top GO terms point to acetylation (N-terminal peptidyl-methionine acetylation; histone H4 acetylation) and chromatin-related processes (subtelomeric heterochromatin formation). Other terms reflect a variety of metabolic pathways (N-acetylglucosamine metabolism; arginine biosynthesis; putrescine and acetoin catabolism; melatonin biosynthesis; mycothiol biosynthesis). The mix suggests a cluster of proteins involved in regulation via acetylation that interfaces with metabolism and chromatin dynamics, with some plant-development signals present. Confidence: Medium","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006044","count":7},{"id":"GO:0010125","count":7},{"id":"GO:0006348","count":7},{"id":"GO:0017196","count":7},{"id":"GO:0009447","count":7}]},{"hash":"411310928263908211","title":"TLR9/LPS-driven innate immune response","description":"Top GO terms indicate responsiveness to lipopolysaccharide, involvement of TLR9 signaling, and broader innate defense against Gram-negative bacteria. While some terms point to development and cell adhesion, the dominant signal across the cluster is innate immune sensing and response to Gram-negative components, consistent with a TLR9/LPS-driven innate immune role.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0034162","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051963","count":2},{"id":"GO:0043318","count":2}]},{"hash":"1224245854995251489","title":"Embryonic development and organ morphogenesis","description":"This cluster's GO terms point to broad vertebrate development and organ formation across many tissues (heart, eye, limb, placenta, gonads, prostate), with regulatory signaling such as estrogen receptor pathways, suggesting a general role in embryogenesis rather than a single tissue.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":7},{"id":"GO:0035116","count":7},{"id":"GO:0001890","count":7},{"id":"GO:0008584","count":7},{"id":"GO:0003148","count":7}]},{"hash":"2190482523699857383","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042274","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006351","count":2},{"id":"GO:1990126","count":1},{"id":"GO:0045053","count":1}]},{"hash":"2067607565128641011","title":"Neural development and actin cytoskeleton regulation","description":"The top GO terms emphasize neural development (neural tube closure, nervous system development) and cytoskeletal dynamics such as barbed-end actin filament capping, along with Rho GTPase signaling and phosphorylation control; signals like TGF-beta response and calcium transport suggest coordinated developmental signaling and adhesion-dependent cell spreading.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0001843","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0050731","count":2}]},{"hash":"754268877680056173","title":"Chromatin remodeling and transcription regulation","description":"This cluster centers on chromatin dynamics and gene expression control, with GO terms for heterochromatin formation, regulation of DNA-templated transcription, and chromatin remodeling being most prominent. Some tissue-development terms appear but are likely secondary; the core signal is DNA-templated transcription linked to chromatin state.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0033601","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006338","count":1}]},{"hash":"379101136509077125","title":"Multi-lineage differentiation","description":"The top GO terms point to development and differentiation across multiple lineages: stem cell maintenance, hemangioblast and goblet cell differentiation, neuron and dendritic cell development, and regulation of immune-related processes (MHC II biosynthesis, leukocyte adhesion). There\u2019s no single tight pathway tying these together, but the common thread is differentiation across diverse cell types, including immune and epithelial lineages, with some regulatory control via miRNA transcription and GM-CSF\u2013related signaling. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035019","count":6},{"id":"GO:0097011","count":6},{"id":"GO:0060480","count":5},{"id":"GO:1904996","count":5},{"id":"GO:0060217","count":5}]},{"hash":"1541121886904493551","title":"Neuronal signaling and synaptic plasticity regulators","description":"This cluster centers on signaling pathways that shape neurons and synapses\u2014Wnt and ephrin receptor signaling, synapse structural plasticity, and nervous system development\u2014along with cytoskeletal and protein stability regulation (GTPase activity, actin remodeling). The recurring emphasis on neural development and synaptic remodeling suggests these proteins collectively regulate neuronal signaling and plasticity rather than a single immune or metabolic pathway.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034260","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0051835","count":5},{"id":"GO:0031532","count":5}]},{"hash":"2170267564522676853","title":"Immune signaling and antigen presentation","description":"The top GO terms are dominated by immune-related processes: type II interferon-mediated signaling, IL-17 production, complement activation (classical pathway), and peptide antigen assembly with MHC class II, pointing to roles in immune signaling and antigen presentation. While iron transport and xenobiotic response appear among the terms, the strongest theme is immune recognition and inflammatory responses, so the cluster likely represents proteins involved in immune signaling and antigen processing/presentation. The bitter taste detection and polysaccharide binding terms may reflect receptor functions related to immune sensing or carbohydrate interactions but do not override the immune-centered theme.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904437","count":5},{"id":"GO:0033216","count":5},{"id":"GO:0060333","count":5},{"id":"GO:0032620","count":5},{"id":"GO:0002506","count":5}]},{"hash":"785532618629205849","title":"Embryonic morphogenesis and immune signaling","description":"The top GO terms point to developmental processes such as metanephric tubule morphogenesis, cartilage condensation, and lymph vessel morphogenesis, indicating tissue morphogenesis. Intersecting terms for immune and inflammatory roles (complement activation, arachidonate secretion, platelet activation, phagocytosis) suggest these proteins also participate in immune signaling. Together, the cluster seems to group genes involved in developmental morphogenesis with immune-related modulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090238","count":6},{"id":"GO:0060355","count":6},{"id":"GO:0010572","count":6},{"id":"GO:0006910","count":6},{"id":"GO:0072287","count":6}]},{"hash":"1522208416017002933","title":"Unknown","description":"The top GO terms span neural development (brain development, interneuron migration) but also many unrelated processes (hepatocyte apoptosis, mitochondrial membrane organization, autophagy, vesicle transport, tight junctions, forskolin response, glucose signaling). There isn\u2019t a single cohesive function that ties these terms together, so a specific, representative cluster label can\u2019t be reliably assigned.","confidence":"","size":7,"edges":18,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":7},{"id":"GO:0034497","count":7},{"id":"GO:0021830","count":7},{"id":"GO:0035208","count":7},{"id":"GO:0010255","count":7}]},{"hash":"1318511165071394778","title":"Embryonic development and proliferation regulation","description":"The cluster features several development-associated terms such as ureteric bud development, limb development, and anterior/posterior axis specification, all pointing to embryogenesis. Additionally, negative regulation of various proliferative processes (fibroblasts, neuroblasts) and signaling modulation (negative regulation of Ras signaling and phosphorylation) fit a theme of growth and differentiation control during development. A couple of meiotic terms appear as outliers, but the dominant signal is developmental regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":2},{"id":"GO:0010801","count":2},{"id":"GO:0001657","count":2},{"id":"GO:0006311","count":1},{"id":"GO:0006366","count":1}]},{"hash":"735339026176488201","title":"Neural development and sensory function","description":"The Top Terms are largely centered on nervous system development and sensory processes (axonogenesis, Schwann cell development, myoblast fusion, visual and pain perception, long-term potentiation), suggesting a coordinated set of proteins involved in neural differentiation, axon guidance, and sensory signaling. Some terms (e.g., abscisic acid signaling) appear tangential, but the dominant theme points to neural development and sensory function.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0019233","count":5},{"id":"GO:0043065","count":5},{"id":"GO:0007520","count":5},{"id":"GO:0014044","count":5}]},{"hash":"774318319573040460","title":"Neural and sensory tissue development","description":"The proteins show enrichment for GO terms tied to nervous/sensory development (retina layer formation, visual perception, Schwann cell development, excitatory signaling) and general multicellular development, with some cell-cycle context. While there are a few non-neural terms (myoblast fusion, angiogenesis, plant hormone signaling), the overarching theme is developmental differentiation in neural and sensory lineages.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0007520","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0060079","count":5}]},{"hash":"2186860270706814981","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":14,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006584","count":3},{"id":"GO:0030205","count":3},{"id":"GO:0018146","count":3},{"id":"GO:0006044","count":3},{"id":"GO:0042403","count":3}]},{"hash":"889226593970561428","title":"Nuclear Chromatin Organization","description":"The GO terms are dominated by chromatin- and nucleus-related processes (localization to chromatin, nucleus organization, chromosome condensation, rDNA heterochromatin formation, histone phosphorylation regulation), indicating a common theme of chromatin organization and nuclear dynamics. Some developmental terms appear incidental rather than defining the cluster's core function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0003209","count":1},{"id":"GO:0033128","count":1},{"id":"GO:0006997","count":1}]},{"hash":"808445830637207394","title":"Rho GTPase\u2013driven immune cell migration","description":"The proteins appear to regulate Rho signaling and general GTPase activity, coordinating actin remodeling (lamellipodium assembly and cell spreading) and restrained cell migration. Immune-focused terms like B cell receptor signaling and thymus development suggest a role in immune cell activation and development, while endothelial barrier establishment aligns with immune cell transmigration. Together, they indicate a theme of Rho\u2013GTPase\u2013mediated cytoskeletal dynamics driving immune cell movement and barrier interactions.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0090557","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0048538","count":7},{"id":"GO:0031666","count":7}]},{"hash":"2250394018663983438","title":"Developmental signaling and differentiation","description":"The cluster includes terms tied to multicellular development and neural differentiation (pyramidal neuron differentiation, axon guidance) along with tissue patterning (salivary gland boundary specification) and angiogenesis, plus signaling-related processes (NF-kappaB activity, STAT phosphorylation, Rho signaling). This suggests proteins involved in development and associated signaling pathways across various tissues.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0021859","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0033564","count":2},{"id":"GO:0007432","count":2}]},{"hash":"1470235539115194919","title":"Ribosome Biogenesis and Cell Division","description":"Dominant terms cluster around ribosome biogenesis and subunit export, plus tRNA modification and general protein synthesis, suggesting proteins involved in ribosome production and translation. Related cell division and septum assembly terms fit as growth-associated processes, while a few outliers like glucose catabolic process do not redefine the main theme. Overall, the cluster reflects ribosome assembly linked to cellular growth and division.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0000747","count":4},{"id":"GO:0000055","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0006007","count":4}]},{"hash":"1212483702976937088","title":"Wnt-Driven Neural and Hair Follicle Development","description":"The GO terms cluster around regulation of canonical and non-canonical Wnt signaling, with associated processes such as dopaminergic neuron differentiation, astrocyte activation, labyrinthine layer branching morphogenesis, and hair follicle development. This suggests a cohesive role for these proteins in Wnt-mediated development affecting neural and epidermal/inner-ear morphogenesis, with additional but secondary references to estradiol response and peptide hormone processing.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0071542","count":2},{"id":"GO:2000052","count":2},{"id":"GO:0071392","count":2},{"id":"GO:0060670","count":2}]},{"hash":"1945772996315914989","title":"Golgi vesicle trafficking and exocytosis","description":"The top terms cluster around vesicle transport and secretory pathway components: COPI-coated Golgi vesicles, endosome-to-plasma membrane transport, synaptic vesicle budding, and calcium-dependent exocytosis. This points to a common function in Golgi-derived vesicle trafficking and secretion. Some terms touch on specialized contexts (hepatocyte apoptosis, spermatid differentiation), but the dominant theme remains vesicle trafficking and exocytosis.","confidence":"Medium","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":2},{"id":"GO:0034379","count":2},{"id":"GO:1905751","count":2},{"id":"GO:0070142","count":2},{"id":"GO:1902647","count":2}]},{"hash":"2056539876942575888","title":"Chaperone-mediated protein folding under stress","description":"The cluster is dominated by GO terms for chaperone activity (chaperone-mediated protein complex assembly, protein refolding) and stress responses (response to heat, oxidative stress regulation). This points to a group of proteins involved in protein quality control during stress. Some terms like scaRNA localization and cell division appear less directly connected and may reflect ancillary roles or noise, but the central theme is chaperone-assisted folding under stress.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051131","count":6},{"id":"GO:0009408","count":6},{"id":"GO:0042220","count":6},{"id":"GO:0090666","count":6},{"id":"GO:1903427","count":6}]},{"hash":"768166034789595901","title":"Nuclear RNA Processing and Spliceosome Assembly","description":"The terms cluster around tRNA processing, spliceosome assembly, mRNA splicing via spliceosome, and snRNP assembly, with supportive links to nuclear import and transcription termination, indicating a cohesive group of nuclear RNA processing and splicing factors. Some chromatin-related terms are present but secondary.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":6},{"id":"GO:0009414","count":5},{"id":"GO:0051170","count":5},{"id":"GO:0006369","count":5},{"id":"GO:0070317","count":5}]},{"hash":"1848167888479506503","title":"Mitotic spindle assembly and microtubule dynamics","description":"The cluster\u2019s top GO terms are dominated by mitosis- and spindle-related processes: metaphase chromosome alignment, spindle midzone assembly, kinetochore\u2013microtubule attachments, and various microtubule depolymerization activities. While there are a couple development-associated terms, the strongest signal clearly centers on mitotic spindle function and microtubule dynamics, suggesting a cohesive role in cell division machinery. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036334","count":3},{"id":"GO:0000742","count":3},{"id":"GO:0048364","count":3},{"id":"GO:0007080","count":3},{"id":"GO:0010938","count":3}]},{"hash":"244392921090561280","title":"Unknown","description":"The GO terms span metabolism (glycolysis), energy-related processes (respiratory exchange, respiratory burst), development (brain development), cell fate (cardiac muscle cell apoptotic regulation), degradation (autophagy), and biosynthesis (cobalamin), with no single cohesive function tying the proteins together. Confidence in a specific, representative label is therefore None.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010666","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0007585","count":2},{"id":"GO:0033133","count":2},{"id":"GO:0045820","count":2}]},{"hash":"264167765491654250","title":"Actin-driven adhesion and membrane signaling","description":"The top GO terms center on actin cytoskeleton dynamics and membrane-associated processes: filopodium and ruffle/podosome assembly, endocytosis, and actin filament branching, coupled with signaling pathways like Wnt, ephrin receptor, and T cell receptor signaling that regulate adhesion and cytoskeletal remodeling. This suggests proteins coordinating actin-driven cell spreading, protrusion formation, endocytic trafficking, and surface signaling, justifying the label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0051835","count":3},{"id":"GO:0046847","count":3}]},{"hash":"1856034111051073955","title":"Neural development and neuron migration","description":"The set of GO terms is dominated by neural development themes: neurogenesis, photoreceptor differentiation, dendrite self-avoidance, and chemorepulsion guiding interneuron migration, plus axon regeneration and regulation of cell proliferation. While a few terms touch non-neural development (vagina development, ovulation), these can reflect broader developmental processes; overall the cluster centers on nervous system development and neuronal differentiation.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0060068","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0001751","count":4}]},{"hash":"1183086943362573476","title":"Neural development and axon guidance","description":"The terms are dominated by neural development, axonogenesis, dendrite patterning, photoreceptor differentiation, and axon/paranode localization, indicating proteins involved in neural differentiation and axon/dendrite guidance and regeneration. Some mixed terms (pericyte, ovulation) appear as noise but do not override the core neural theme.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001751","count":4},{"id":"GO:0070593","count":4},{"id":"GO:0021836","count":4},{"id":"GO:1904238","count":4},{"id":"GO:0042698","count":4}]},{"hash":"1033100241119923461","title":"Osteoclast signaling and cytoskeletal remodeling","description":"The terms converge on osteoclast biology and cytoskeletal dynamics, including osteoclast development, podosome assembly, actin cytoskeleton reorganization, and responses to mechanical stimuli. The presence of signaling pathways such as Wnt, ERK, EGFR, and ephrin, along with ubiquitination, supports a bone-resorption signaling context where cytoskeletal remodeling is central. This combination strongly points to osteoclast differentiation and function within the bone remodeling process.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":6},{"id":"GO:0071260","count":6},{"id":"GO:0031532","count":6},{"id":"GO:0035264","count":6},{"id":"GO:0016567","count":6}]},{"hash":"535219557302943075","title":"DNA Replication and Transcription Core","description":"The dominant GO terms are DNA-templated transcription and DNA replication (both with the highest counts), indicating the cluster is centered on nuclear gene expression and genome duplication. While there are additional, more diverse signaling and regulatory terms (e.g., Kit signaling, angiogenesis), they appear supplementary to the core transcription/replication theme. This makes \"DNA Replication and Transcription Core\" a concise and representative label.","confidence":"High","size":6,"edges":8,"triangles":3,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0048679","count":5},{"id":"GO:0002688","count":5},{"id":"GO:0042698","count":5}]},{"hash":"1525341052734269105","title":"Unknown","description":"The top GO terms span metabolism (glycolytic, dihydrolipoamide, guanine), redox homeostasis, and stress or development responses (cold, ethanol, LPS, cerebral cortex development, megakaryocyte differentiation), with no single unifying function clearly dominating. This scattered set suggests either multifaceted proteins or noisy/ambiguous annotations, making a cohesive functional label unreliable.","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045654","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0051068","count":2},{"id":"GO:0046098","count":2}]},{"hash":"1969186615127330481","title":"Immune Tolerance and Organ Development","description":"The cluster\u2019s top GO terms heavily feature immune regulation and tolerance (negative regulation of chronic inflammatory response; tolerance induction to self antigen; CD4+ Treg differentiation), suggesting an immune-regulatory theme. There are also several development-related terms for various tissues (glomerular endothelium, trabecular meshwork, prostate stroma, lung secretory cells), pointing to broader tissue differentiation processes that accompany immune regulation in this set.","confidence":"Medium","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002677","count":6},{"id":"GO:0090419","count":6},{"id":"GO:0072011","count":6},{"id":"GO:0002930","count":6},{"id":"GO:0060741","count":6}]},{"hash":"200186213152868256","title":"miRNA processing and transcription regulation cluster","description":"This cluster is dominated by GO terms related to RNA metabolism (miRNA catabolic process, pre-miRNA processing, mRNA stabilization) and transcription regulation (DNA-templated transcription, termination regulation, transcription antitermination), suggesting proteins that coordinate RNA processing with transcription control. Some outlier terms may reflect broader regulatory roles, but the core theme centers on RNA processing and transcription regulation.","confidence":"High","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":2},{"id":"GO:1902219","count":2},{"id":"GO:0031054","count":2},{"id":"GO:0070934","count":2},{"id":"GO:0006351","count":2}]},{"hash":"791723792699235401","title":"Neural development and morphogenesis","description":"The cluster\u2019s top GO terms include neurogenesis, nervous system development, and embryonic retina morphogenesis, indicating a core theme of neural development; additional terms for forebrain proliferation and other morphogenetic processes suggest broader embryonic tissue patterning.","confidence":"Medium","size":6,"edges":12,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060059","count":3},{"id":"GO:0021846","count":3},{"id":"GO:0048807","count":3},{"id":"GO:0050872","count":3},{"id":"GO:0048672","count":3}]},{"hash":"182170968689084424","title":"Protein maintenance under oxidative stress","description":"The dominant signals are protein modification and repair in response to oxidative stress, indicating a focus on maintaining protein integrity under redox conditions. A few terms touch on serine/glycine and folate metabolism, but the strongest theme centers on protein quality control during oxidative challenges.","confidence":"Medium","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006464","count":3},{"id":"GO:0030091","count":3},{"id":"GO:0006979","count":3},{"id":"GO:0055114","count":3},{"id":"GO:1904482","count":1}]},{"hash":"1631485398032749871","title":"Synaptic signaling and plasticity regulation","description":"Go terms point to neuronal synaptic function, with positive/negative regulation of synaptic signaling, modification of synaptic structure, ERK signaling linked to plasticity, and transcription/splicing processes that support synaptic changes. Although there are also cytoskeletal and ubiquitination signals, the core theme is regulation of synaptic signaling and structural plasticity in neurons.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0050975","count":3},{"id":"GO:0043149","count":3},{"id":"GO:0033138","count":3}]},{"hash":"847162172707074628","title":"Cytoskeletal Dynamics and Adhesion Signaling","description":"The top GO terms cluster around actin-driven processes (lamellipodium morphogenesis, cell adhesion, adherens junction localization) and signaling pathways (Rho signaling, regulation of JNK/p38 MAPK cascades), plus innate immune response. This points to a cohesive role in coordinating cytoskeletal remodeling and cell\u2013cell adhesion with MAPK signaling, with immune signaling intersecting these processes. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046328","count":6},{"id":"GO:0045087","count":6},{"id":"GO:1900026","count":5},{"id":"GO:0072673","count":5},{"id":"GO:0035023","count":5}]},{"hash":"2225787889581940952","title":"Clathrin-mediated endocytosis and endosomal sorting","description":"These proteins cluster around the endocytic vesicle formation and trafficking pathway: clathrin-dependent endocytosis, clathrin coat assembly, vesicle cargo loading, and multivesicular body sorting with late endosome-to-vacuole transport. While a few terms touch broader regulatory processes (receptor-mediated endocytosis, PDGFR signaling, gastric acid secretion, apoptosis), the dominant signal is clathrin\u2011dependent endocytosis and endosomal sorting, suggesting the cluster represents components of this trafficking route.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032511","count":4},{"id":"GO:1902961","count":4},{"id":"GO:0035459","count":4},{"id":"GO:0072583","count":4},{"id":"GO:0060453","count":4}]},{"hash":"2294548833987431900","title":"Neural development and synapse formation","description":"This cluster is enriched for brain and nervous system development terms, plus presynaptic active zone assembly and cadherin-mediated cell adhesion, highlighting neural development and synaptic connectivity as the central theme, with some pleiotropic terms from other tissues.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0051796","count":5},{"id":"GO:0033626","count":5},{"id":"GO:0086073","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0048023","count":5}]},{"hash":"271855848314251594","title":"Detoxification and redox homeostasis","description":"The top GO terms cluster around cellular oxidant detoxification, glutathione metabolism, toxin catabolic processes, and responses to arsenic, all pointing to redox balance and detox pathways. Additional terms like vacuolar acidification, chloride transmembrane transport, and regulation of mitochondrial membrane potential suggest coordinated organellar ion and pH homeostasis that support detox processes. Some terms related to growth and morphogenesis are peripheral, but the core theme centers on detoxification and redox regulation.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0051881","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0007035","count":2},{"id":"GO:0006749","count":2}]},{"hash":"2255402789182265421","title":"Phosphorylation and NFAT signaling in muscle and vascular development","description":"The cluster shows enrichment for phosphorylation/dephosphorylation processes and the regulation of calcineurin-NFAT signaling, which are key to muscle fiber development and vascular morphogenesis (branching of blood vessels, lymphangiogenesis). While there are outlier terms related to metabolism and kinetochore localization, the dominant pattern points to a signaling module coordinating muscle differentiation with vessel formation via phosphorylation-dependent pathways, making this a cohesive, functionally interpretable group.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0046085","count":2},{"id":"GO:0006195","count":2},{"id":"GO:0016310","count":2}]},{"hash":"1309884690060392648","title":"Synaptic vesicle trafficking and neurotransmitter release","description":"The top GO terms cluster around regulation of vesicle priming and recycling, norepinephrine secretion, exocytic insertion of neurotransmitter receptors, and long-term potentiation, indicating a cohesive role in synaptic transmission and vesicle trafficking. Some terms about Golgi ribbon formation and cornified envelope assembly appear but are likely secondary or shared trafficking themes. Confidence: High","confidence":"","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0010701","count":4},{"id":"GO:1903422","count":4},{"id":"GO:0010807","count":4},{"id":"GO:0098967","count":4},{"id":"GO:0060291","count":4}]},{"hash":"284654601291391290","title":"Vitamin and sterol biosynthesis cluster","description":"The top GO terms are dominated by biosynthetic processes (cobalamin, biotin, antibiotic, and sterol biosynthesis), suggesting a group of proteins involved in producing small molecules and lipids. While there are some general cellular-process terms, the recurring biosynthesis theme best defines this cluster as metabolic rather than signaling or transport. Medium","confidence":"Medium","size":6,"edges":9,"triangles":5,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009236","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0035690","count":3},{"id":"GO:0034970","count":3},{"id":"GO:0000056","count":3}]},{"hash":"1333674245506285666","title":"Unknown","description":"The terms point to a scattered mix of xenobiotic response, lipid metabolism, cell movement, development, and even insect pigmentation, with some obsolete terms; there is no clear, single theme binding the cluster.","confidence":"","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":4},{"id":"GO:0033327","count":4},{"id":"GO:0042136","count":4},{"id":"GO:0010761","count":4},{"id":"GO:0006665","count":4}]},{"hash":"784183758333115457","title":"Unknown","description":"This cluster contains a highly diverse set of GO terms, spanning reproductive processes, metabolism, plant secondary metabolism, neural development and regeneration, immune cell migration, and membrane localization, with no clear unifying function. Given the lack of a common theme, Unknown with no well-supported representative function is appropriate.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001542","count":2},{"id":"GO:0000103","count":2},{"id":"GO:0009812","count":2},{"id":"GO:0061003","count":1},{"id":"GO:0021511","count":1}]},{"hash":"1081533275082633194","title":"Bacterial cell wall and LPS glycan biosynthesis","description":"This cluster is enriched for GO terms tied to sugar biosynthesis and cell envelope components (glycogen, UDP-N-acetylglucosamine, O-antigen, lipopolysaccharide biosynthesis, and cell wall organization). The shared theme is enzymes that construct bacterial glycans forming the outer membrane and cell wall, despite a few outliers such as catabolic processes that are less central to the theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":3},{"id":"GO:0009243","count":2},{"id":"GO:0019255","count":2},{"id":"GO:0006048","count":2},{"id":"GO:0006148","count":2}]},{"hash":"1824765367399569788","title":"Embryonic Tissue Morphogenesis and Immune Signaling","description":"The terms point to developmental morphogenesis across various tissues (metanephric tubules, cartilage condensation, lymph vessels) suggesting a tissue development theme. At the same time, immune-related terms (complement activation, phagocytosis recognition, platelet activation) imply concurrent remodeling or signaling during development. This combination supports labeling the cluster as embryonic tissue morphogenesis with immune signaling.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090238","count":3},{"id":"GO:0060355","count":3},{"id":"GO:0010572","count":3},{"id":"GO:0006910","count":3},{"id":"GO:0072287","count":3}]},{"hash":"1036517390886312080","title":"Ribosome biogenesis and cytoplasmic translation","description":"The top GO terms cluster around cytoplasmic translation and ribosome-related processes (cytoplasmic translation, ribosomal small subunit biogenesis, and ribosomal large subunit export from nucleus), indicating a grouping of proteins involved in ribosome assembly and protein synthesis. Some outliers (viral RNA genome replication, neuromuscular balance, and cell fusion) are present but less representative of the core function. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":3},{"id":"GO:0050885","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0039694","count":2},{"id":"GO:0090529","count":2}]},{"hash":"1699503982678836616","title":"KIT signaling and angiogenesis","description":"The GO terms show a strong enrichment for KIT signaling pathway, positive regulation of angiogenesis, and PI3K/AKT signaling, pointing to a core theme of growth-factor\u2013driven signaling that promotes vascular development and cell motility. Additional terms like PMA response (PKC-related) and leukocyte chemotaxis support downstream signaling and migration, while axon regeneration and reproductive development terms suggest broader involvement in developmental signaling. Overall, the cluster likely reflects KIT-centered signaling and angiogenic processes.","confidence":"High","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048679","count":5},{"id":"GO:0002688","count":5},{"id":"GO:0042698","count":5},{"id":"GO:0038109","count":5},{"id":"GO:1902002","count":5}]},{"hash":"1495722040894391739","title":"Mitotic Cell Cycle Regulators","description":"The top GO terms center on progression through mitosis: G1/S and G2/M transitions, re-entry into mitosis, and regulation of spindle pole separation, indicating proteins that coordinate cell cycle events. Some terms related to transcription and epithelial proliferation appear, but the dominant signal is mitotic regulation and cell cycle control.","confidence":"High","size":6,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":6},{"id":"GO:2000775","count":6},{"id":"GO:0033598","count":6},{"id":"GO:0046626","count":6},{"id":"GO:0006351","count":6}]},{"hash":"1598687931518157757","title":"Embryonic development and apoptosis","description":"The GO terms point to development and morphogenesis across several tissues (retina, forebrain, thymus, adipose), plus neurogenesis and apoptotic pathways, with a note of xenobiotic response. This suggests a broad developmental/differentiation theme with some programmed cell death signaling, rather than a single pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060059","count":2},{"id":"GO:0021846","count":2},{"id":"GO:0048807","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0048538","count":2}]},{"hash":"2141806816671064306","title":"Cerebellar neural development and synaptic signaling","description":"This cluster centers on neural development and synaptic function, highlighted by cerebellar Purkinje cell layer formation, neurotransmitter secretion, and long-term synaptic depression, as well as prepulse inhibition. Additional signals for Wnt pathway regulation and cytoskeletal/adhesion dynamics (Rho signaling, adherens/tight junctions) support neurite outgrowth and synapse organization, consistent with cerebellar development and connectivity. Overall, it points to cerebellar neural development and synaptic signaling.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0032416","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0071896","count":6},{"id":"GO:0060134","count":6},{"id":"GO:0007269","count":6}]},{"hash":"1093549522000260803","title":"Neuronal growth and axon extension","description":"The GO terms indicate neuron-specific development processes, including positive regulation of neurotrophin signaling, dendrite development, and axon extension (including positive regulation of axon extension). Also supporting elements like integrin-mediated adhesion and translation regulation align with neuronal growth and synaptic formation, suggesting this cluster centers on neuronal development with a focus on axon/dendrite growth and connectivity.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051388","count":2},{"id":"GO:1900006","count":2},{"id":"GO:0051602","count":2},{"id":"GO:1903422","count":2},{"id":"GO:0007275","count":2}]},{"hash":"2087209012946078105","title":"Tissue development and wound repair under stress","description":"The top GO terms point to developmental and differentiation processes (hair cycle regulation; mammary gland alveolus development; neural fold elevation) alongside tissue remodeling (connective tissue replacement in wound healing) and stress-response pathways (response to redox state; hypoxia signaling). This suggests a cluster of proteins involved in coordinating tissue development and repair under oxidative and hypoxic conditions, with ancillary hints from light-detection processes and maternal-related signaling. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051775","count":5},{"id":"GO:0042634","count":4},{"id":"GO:0002248","count":4},{"id":"GO:0061030","count":4},{"id":"GO:0021502","count":4}]},{"hash":"516220319900821262","title":"Calcium-Dependent Developmental Morphogenesis","description":"This cluster centers on calcium signaling tied to developmental differentiation and morphogenesis. Terms like regulation of calcium ion response, postsynaptic calcium regulation, regulation of calcineurin-NFAT signaling, and EMT, along with morphogenesis-oriented terms (adenohypophysis development, branching morphogenesis of blood vessels, astrocyte differentiation), point to a theme of calcium-mediated developmental processes shaping cell fate and tissue structure.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042994","count":4},{"id":"GO:0048855","count":4},{"id":"GO:0001569","count":4},{"id":"GO:0099566","count":4},{"id":"GO:0051531","count":4}]},{"hash":"1008607497191765683","title":"Lipid metabolism and organelle organization","description":"The proteins show strong enrichment for fatty acid catabolic and lipid biosynthetic processes (triglyceride and galactolipid biosynthesis) as well as lipid droplet organization, alongside GO terms for endoplasmic reticulum and nuclear organization (lamin depolymerization). This points to a cluster centered on lipid metabolism with links to organelle structure and nuclear architecture.","confidence":"High","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009062","count":3},{"id":"GO:0007078","count":3},{"id":"GO:0007029","count":3},{"id":"GO:0006997","count":3},{"id":"GO:0034389","count":3}]},{"hash":"562607921960948394","title":"Neural development and axon/dendrite patterning","description":"Majority of top terms describe neural development and connectivity: neurogenesis, axonal fasciculation, dendrite self-avoidance, synapse assembly, and paranode localization, plus interneuron migration cues. The presence of outliers like innate immune response and heart development likely reflect broader developmental themes rather than core cluster function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0042552","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007507","count":5}]},{"hash":"1434610614211849990","title":"Mitotic cell cycle and ER-Golgi trafficking","description":"The top GO terms cluster around mitosis (mitotic spindle assembly, mitotic cell cycle, cell division, cell population proliferation) and vesicle trafficking between the ER and Golgi (ER to Golgi transport, Golgi to ER retrograde transport, COPII-coated vesicle budding). This points to a functional module focused on cell division coupled with secretory pathway transport, with brain development and multicellular growth likely reflecting broader developmental context rather than a separate mechanism. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0051301","count":5}]},{"hash":"398116364912133490","title":"Developmental chromatin remodeling and transcription","description":"The cluster centers on chromatin remodeling and DNA-templated transcription, with supportive signals for development-related proliferation and differentiation across multiple tissues (lens, prostatic bud, megakaryocytes, spermatid differentiation, mesenchymal stem cells), and hints of TGF-beta\u2013mediated responses. This suggests a cohesive role in regulating gene expression during development via chromatin state changes.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043046","count":3},{"id":"GO:0006351","count":3},{"id":"GO:2001111","count":3},{"id":"GO:0043044","count":3},{"id":"GO:0071560","count":3}]},{"hash":"182227875298097137","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":5},{"id":"GO:0003273","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0045216","count":4},{"id":"GO:0060901","count":4}]},{"hash":"1570326399983426460","title":"Immune and hematopoietic lineage differentiation","description":"The cluster\u2019s top GO terms point to development and differentiation of hematopoietic/immune lineages (hemangioblast differentiation, myeloid dendritic cell differentiation, leukocyte adhesion), accompanied by transcriptional and epigenetic regulation (negative regulation of transcription by RNA pol II, miRNA transcription, CpG island methylation-mediated regulation). While some terms touch broader developmental processes (goblet cell differentiation, peripheral nervous system development), the strongest signal centers on immune/hematopoietic lineage specification and its transcriptional control.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0060480","count":4},{"id":"GO:1904996","count":4},{"id":"GO:0060217","count":4},{"id":"GO:0061614","count":4}]},{"hash":"1666155163065538532","title":"Developmental actin cytoskeleton remodeling","description":"This cluster centers on developmental contexts (brain, cerebral cortex, imaginal disc wing patterning) and actin-related processes (actin nucleation, actin filament network formation, ER polarization). The common thread appears to be actin-driven morphogenesis and cellular remodeling during development, with some related organelle dynamics (mitochondrial fission) that can accompany cytoskeletal changes. While a meiosis-related term is less connected, the dominant theme is actin-mediated developmental morphogenesis. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0021987","count":2},{"id":"GO:0048854","count":2},{"id":"GO:0090140","count":2},{"id":"GO:0051758","count":2}]},{"hash":"1485172981227297209","title":"Ubiquitin-Mediated Proteolysis and Signaling","description":"The cluster is dominated by GO terms related to ubiquitin-dependent protein catabolic processes and various ubiquitination types (autoubiquitination, K63-linked), plus regulation of signaling pathways such as JNK and canonical Wnt. This points to proteins involved in attaching ubiquitin to substrates and modulating signaling, linking proteostasis with signal transduction. Some terms like ERAD pathway and negative regulation of ubiquitin-dependent proteolysis support this theme, while a few annotations (placenta morphogenesis, fatty acid biosynthesis) may reflect broader roles or annotation noise. Overall, the core theme appears to be ubiquitin-mediated regulation of protein turnover and signaling.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046328","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0051865","count":4},{"id":"GO:2000059","count":3}]},{"hash":"871618234091958665","title":"Tumor Immunosurveillance by NK and T Cells","description":"The top GO terms cluster around immune recognition and response to tumor cells, including positive regulation of NK cell\u2013mediated cytotoxicity against tumor targets, positive regulation of T cell proliferation, detection of tumor cells, and cytokine regulation (interleukin-10). Additional terms on cell adhesion and protein localization to cell junction support immune synapse formation. A few terms (lens morphogenesis, symbiont entry) appear as noise, but the dominant theme is tumor-related immune surveillance and cytotoxic T/NK cell activity.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002860","count":3},{"id":"GO:0046814","count":3},{"id":"GO:0042102","count":3},{"id":"GO:0002355","count":3},{"id":"GO:0007157","count":3}]},{"hash":"1041601054234094856","title":"Neural development and axonogenesis","description":"Most terms point to neural morphogenesis and axon development (optic nerve morphogenesis, axonogenesis) with supportive terms for cell-matrix adhesion and migration; a few entries reference neural responses to external chemicals (cocaine, ethanol) and protein regulation that may support neuronal differentiation, suggesting a cohesive theme around neural development and axon guidance.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0010763","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0032435","count":2}]},{"hash":"682286370124975359","title":"Golgi-ER vesicle trafficking and exocytosis","description":"The GO terms cluster around transport between the ER and Golgi and intra-Golgi compartments (ER to Golgi transport, intra-Golgi transport, ERGIC fusion, retrograde transport), plus downstream exocytic processes such as mucus secretion and postsynaptic receptor insertion. This points to a coherent theme of vesicle trafficking through the Golgi-ER axis and secretion, including neuronal and secretory pathways.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0090316","count":1},{"id":"GO:1990668","count":1},{"id":"GO:0070254","count":1}]},{"hash":"2174676533283085037","title":"Neuronal growth and cytoskeletal signaling","description":"The GO terms cluster around neuron projection development, axon extension, cell adhesion, and regulation of Rho signaling, all pointing to neurite outgrowth and cytoskeletal remodeling. Some immune-related terms appear, but the dominant theme supports neuronal growth and cytoskeletal dynamics.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0048675","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0045214","count":2}]},{"hash":"495123110624246801","title":"Transcription machinery and transcription-coupled repair","description":"The Top Terms cluster around DNA-templated transcription (including RNA Pol II initiation, general transcription, and elongation) and mRNA capping, with several terms pointing to nucleotide-excision repair components associated with transcription-coupled repair. The presence of some Pol I-related terms is less representative but does not overshadow the transcription-focused signal. Overall, these proteins appear to function together in transcription with a link to DNA repair coupling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0006367","count":2},{"id":"GO:0006293","count":1},{"id":"GO:0006366","count":1}]},{"hash":"833505275886821227","title":"Negative regulation of signaling and stress responses","description":"The terms show multiple instances of dampening or inhibiting signaling across diverse pathways (respiratory burst, PKC, calcineurin-NFAT), as well as modulation of stress responses (ER unfolded protein response) and related cellular processes like focal adhesion. This suggests a cohesive role for the proteins as regulators that restrain signaling and stress-related activities, rather than activators.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060268","count":1},{"id":"GO:1900103","count":1},{"id":"GO:0046856","count":1},{"id":"GO:0051531","count":1},{"id":"GO:0007480","count":1}]},{"hash":"1833483341804255304","title":"Angiogenesis and vascular remodeling with coagulation","description":"These proteins cluster around blood vessel formation and remodeling: strong signals for angiogenesis, collagen/fibril organization, ECM remodeling, and fibrinolysis, plus regulation of platelet aggregation and endothelial cell survival. Together they point to vascular development and hemostasis processes being represented in this group.","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090331","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0001525","count":2},{"id":"GO:2000352","count":2}]},{"hash":"676322998159849367","title":"Neuronal development and synaptic exocytosis","description":"The top GO terms cluster strongly around brain development, calcium signaling, and dense core granule exocytosis, all central to neuronal function and synaptic transmission. The presence of presynapse-to-nucleus signaling and Rho-mediated cytoskeletal regulation supports neural development and synaptic remodeling, even though a few terms are more general or ancillary. Overall, the terms point to neuronal signaling and neurotransmitter release as the core theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0038028","count":2},{"id":"GO:0045943","count":2},{"id":"GO:0071277","count":2}]},{"hash":"1694003399467056272","title":"Cell division and ribosome biogenesis","description":"The cluster centers on cell division processes, highlighted by CENP-A chromatin assembly, vacuole inheritance, and general cell division terms. It also includes ribosome biogenesis signals such as maturation of SSU/LSU rRNA and mRNA splicing, with supporting processes like ER-to-Golgi transport and ubiquitination that govern protein processing and regulation during division. Overall, the terms point to a core theme of preparing the cell for division and maintaining ribosome assembly, with ancillary trafficking and regulatory roles.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000011","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0000463","count":2}]},{"hash":"494425808659518324","title":"Fertilization: Zona Pellucida Binding and Acrosome Reaction","description":"The strongest cohesive signal among the terms is fertilization-related: sperm binding to the zona pellucida, zona pellucida penetration, and regulation of the acrosome reaction, which together point to sperm-egg interaction and acrosome activation. Other terms in the list (developmental and ECM-related processes) appear less coherent with this focal function, so the label centers on fertilization terminology to be specific and representative. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018146","count":3},{"id":"GO:0008542","count":2},{"id":"GO:0030879","count":2},{"id":"GO:0060055","count":2},{"id":"GO:0060046","count":2}]},{"hash":"640730133546351693","title":"Phototransduction and cardiac GPCR signaling","description":"This cluster centers on opsin-regulated signaling and visual perception, combined with core GPCR signaling elements like phosphorylation, GTPase activity, and adenylate cyclase/cAMP pathways. The presence of heart development and regulation of cardiac muscle contraction suggests these signaling pathways also modulate cardiac function, pointing to a shared GPCR-cAMP signaling theme across vision and heart-related processes.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022400","count":5},{"id":"GO:0006468","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007190","count":5},{"id":"GO:0055117","count":5}]},{"hash":"651822624379256185","title":"B/T cell cytokine signaling and NF-\u03baB regulation","description":"The dominant GO terms are cytokine production, B cell receptor signaling, and NF-\u03baB-related regulation, which together point to immune signaling and cytokine control; a few development-related terms seem like outliers or annotations unrelated to the core function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0001816","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0002725","count":1}]},{"hash":"1460067751245093676","title":"Metabolic and stress-response proteins","description":"GO terms show a strong emphasis on metabolism (cholesterol biosynthesis, glucose metabolism, L-glutamine metabolism) across the proteins. Additional terms indicate cellular stress response (response to cadmium ion) and signaling roles (Kit signaling pathway) but these are less represented. The diversity of terms beyond metabolism suggests a primarily metabolic cluster with broader functional annotations rather than a single unified function. Therefore the label Metabolic and stress-response proteins captures the core theme with moderate confidence.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006695","count":2},{"id":"GO:0006006","count":2},{"id":"GO:0014850","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0006541","count":2}]},{"hash":"346237868266679060","title":"Dopaminergic Synaptic Signaling and Calcium Regulation","description":"The top GO terms point to dopaminergic synaptic transmission and regulation of calcium release into the cytosol, with additional references to glutamate secretion and neuronal survival. This combination suggests a neuronal signaling cluster focused on dopamine-mediated synaptic activity and calcium-dependent neurotransmitter release, with a potential neuroprotective angle; a few metabolic terms are present but secondary. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0043154","count":2},{"id":"GO:0001963","count":1},{"id":"GO:0001933","count":1}]},{"hash":"2141579528067597521","title":"Neuronal Synaptic Transmission and Mitochondrial Regulation","description":"This cluster centers on neuronal signaling (neuron-neuron synaptic transmission; learning; fear response) and mitochondrial-related processes (calcium import into mitochondrion; protein import into mitochondrial matrix; regulation of autophagy of mitochondrion; ROS regulation; ion transport; cilium assembly), suggesting an integrated role of synaptic function with mitochondrial dynamics and quality control in neurons, potentially affecting learning and behavior as well as ciliogenesis.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007270","count":5},{"id":"GO:0036444","count":5},{"id":"GO:0030150","count":5},{"id":"GO:0001662","count":5},{"id":"GO:0031101","count":5}]},{"hash":"25472467982692153","title":"DNA-Templated Transcription Regulation","description":"The cluster is dominated by GO terms related to transcription and its regulation of DNA-templated processes, suggesting a core function in transcriptional control; the other one-off terms appear incidental and do not define a unifying mechanism.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0021590","count":1},{"id":"GO:0009409","count":1},{"id":"GO:0070427","count":1}]},{"hash":"1554578130184810581","title":"G2/M Cell Cycle Regulation and Stress Signaling","description":"The top terms center on mitotic control (G2/M transition) and peptidyl-tyrosine dephosphorylation, indicating regulation of the cell cycle via phosphatase activity. Additional signaling-related terms (epinephrine response, cAMP) suggest modulation by signaling pathways, with redox homeostasis and occasional stress/development terms reflecting broader cellular stress context. Overall, the cohesive theme is cell cycle regulation influenced by signaling and redox-stress cues.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0035335","count":2},{"id":"GO:0071872","count":2},{"id":"GO:0051591","count":2}]},{"hash":"1717962850971561745","title":"Mitotic spindle assembly and chromosome alignment","description":"The top GO terms strongly point to mitosis and microtubule dynamics (mitotic spindle assembly, metaphase chromosome alignment, spindle midzone assembly, kinetochore\u2013spindle interactions, and microtubule depolymerization), indicating a protein cluster focused on spindle organization and chromosome segregation. A few developmental terms appear but are less represented, reinforcing that the central theme is mitotic spindle function.","confidence":"High","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0036334","count":3},{"id":"GO:0000742","count":3},{"id":"GO:0048364","count":3},{"id":"GO:0007080","count":3}]},{"hash":"1298147631143531651","title":"Dopaminergic Mitochondrial Oxidative Stress Response","description":"The top GO terms cluster around dopaminergic synaptic transmission and mitochondrial/oxidative stress processes: regulation of mitochondrial membrane potential, oxidative phosphorylation/uncoupler activity, and antioxidant-related activities (SOD regulation, oxidant detoxification). While some terms are obsolete, the core pattern suggests neurons with mitochondria-focused oxidative balance, with metabolic context from glutamine and glyoxal responses. This supports a label that combines dopaminergic signaling with mitochondrial oxidative stress management.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1903168","count":2},{"id":"GO:0001963","count":2},{"id":"GO:0098869","count":2},{"id":"GO:1901671","count":2},{"id":"GO:0006541","count":2}]},{"hash":"885849978167078678","title":"Neural and sensory development","description":"The top GO terms cluster around neural lineage specification and brain/sensory region morphogenesis: subpallium neuron fate commitment, auditory receptor cell fate determination, oligodendrocyte development, and midbrain-hindbrain boundary morphogenesis, as well as regulation of timing of subpallium neuron differentiation. These imply a coherent theme of neural development and sensory cell specification. A few terms (immune response, heart morphogenesis) are less related and may reflect broader annotations, but the dominant signal points to neurodevelopment and sensory lineage. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060163","count":3},{"id":"GO:2000981","count":3},{"id":"GO:2000802","count":3},{"id":"GO:0014003","count":3},{"id":"GO:0006959","count":3}]},{"hash":"1369570693479967090","title":"Neural development and synaptic plasticity","description":"This cluster centers on neural development and synaptic function: terms like excitatory postsynaptic potential, long-term synaptic potentiation, axonogenesis, visual perception, and Schwann cell development point to neuronal differentiation and maturation, synaptic signaling, and sensory processing. A couple of outlier terms (G2/M mitotic transition and abscisic acid signaling) are less related to neural processes, but the dominant theme remains neural development and synaptic activity.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0014044","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0010800","count":5}]},{"hash":"1416601977696656332","title":"Developmental Regulation and Stress Response","description":"The proteins are linked to developmental processes (skeletal system and forebrain development) and multicellular development, with additional links to fundamental cellular processes (mitotic cell cycle, transcription) and stress-related pathways (hypoxia response, ER-stress\u2013driven apoptosis). This points to a cluster centered on development with concurrent cell-cycle control and stress-induced regulation, rather than a single narrowly defined function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001501","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0071456","count":4}]},{"hash":"1454244090487412665","title":"Unknown","description":"The terms are a scattered mix of metabolic and developmental processes (fatty acid metabolism, methionine biosynthesis, alkaloid/antibiotic biosynthesis, xenobiotic degradation, and secondary shoot formation) with no clear shared function or pathway for the cluster, and with no connections among proteins (0 edges/0 triangles). This yields no coherent theme for a specific label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009086","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0006631","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0010223","count":1}]},{"hash":"918445769063544405","title":"Neural development and axon guidance","description":"These terms point to neural development and axis formation: neurogenesis, axonogenesis, interneuron migration cues, dendrite patterning, and axon compartment localization, with additional ECM and vascular context that support neural circuitry.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"wound healing","top_go_terms":[{"id":"GO:0001751","count":5},{"id":"GO:0070593","count":5},{"id":"GO:0021836","count":5},{"id":"GO:1904238","count":5},{"id":"GO:0042698","count":5}]},{"hash":"505590372714124629","title":"Adaptive Immune Activation and Antiviral Signaling","description":"The cluster\u2019s GO terms strongly point to adaptive immune functions (type II interferon response, CD8+ T cell proliferation, lymph node development, eosinophil migration) and antiviral signaling, with some ancillary terms (redox/mitochondrial targeting, growth factor responses) that are less central but not contradictory. This suggests a cohesive theme around immune activation and antiviral regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0006626","count":2},{"id":"GO:1902230","count":1},{"id":"GO:0009409","count":1},{"id":"GO:0045071","count":1}]},{"hash":"1080320860549374567","title":"ER Targeting and Translocation","description":"This cluster is enriched for GO terms related to directing proteins to the endoplasmic reticulum, including SRP-dependent cotranslational targeting, Sec complex\u2013mediated transport, and ER-associated retrograde transport/ERAD. These together define a coherent module of ER targeting and translocation machinery, with minor developmental terms likely representing background annotations.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030970","count":1},{"id":"GO:0006605","count":1},{"id":"GO:0039019","count":1},{"id":"GO:0043952","count":1},{"id":"GO:0070843","count":1}]},{"hash":"868640391833018452","title":"Receptor tyrosine kinase signaling in hematopoiesis","description":"This cluster centers on signaling pathways initiated by RTKs such as KIT and PDGFR\u03b2, including regulation of NFAT signaling, hematopoietic progenitor differentiation, and growth-related processes. The presence of leukotriene biosynthesis and Wnt/PCP regulation suggests integration with inflammatory signaling and cell polarity during development, consistent with RTK-mediated control of hematopoietic growth and immune function.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":5},{"id":"GO:0051531","count":4},{"id":"GO:0038109","count":4},{"id":"GO:0019370","count":4},{"id":"GO:2000096","count":4}]},{"hash":"17565795620500388","title":"Multilineage differentiation","description":"The top GO terms point to development and cell fate specification across many tissues (skeletal muscle, endocrine pancreas, neurons/oligodendrocytes, inner ear, heart valve formation, dendritic cells) plus regulatory responses like estradiol signaling and humoral immunity. There is no single pathway tying all terms; instead, the cluster seems to collect proteins involved in lineage-specific differentiation programs across diverse tissues.","confidence":"Medium","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":3},{"id":"GO:0071392","count":3},{"id":"GO:0031018","count":3},{"id":"GO:2001200","count":2},{"id":"GO:0060163","count":2}]},{"hash":"967259802039774497","title":"Multisubstrate membrane transporters","description":"The top GO terms describe transmembrane transport for a wide variety of substrates (potassium, nitrate, phosphate, nitrite, sodium, arabinose, vitamins, xenobiotics, and a phenylacetate derivative), indicating these proteins function broadly as membrane transporters rather than substrate-specific enzymes. This pattern supports a label of multisubstrate transmembrane transporters.","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0006855","count":2},{"id":"GO:1900754","count":2}]},{"hash":"626444211142949214","title":"Tissue morphogenesis and cell adhesion","description":"This cluster centers on processes involved in shaping tissues and guiding cellular interactions, including glomerulus and gland morphogenesis, GI epithelium maintenance, dendrite patterning, neuronal migration, branching, and Rho-mediated signaling, all linked by a common theme of development and cell adhesion; an immune term appears as an outlier.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070593","count":1},{"id":"GO:0072102","count":1},{"id":"GO:0035023","count":1},{"id":"GO:0030277","count":1},{"id":"GO:0007155","count":1}]},{"hash":"231766322018566461","title":"Adaptive Immune Signaling","description":"The top GO terms are dominated by adaptive immune response and NF-kappaB-related regulation, with related processes like ubiquitination and TGF-beta signaling, indicating these proteins are primarily involved in immune signaling pathways rather than other functions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0046676","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0016567","count":2}]},{"hash":"1279769553225945179","title":"Wnt pathway regulators and apoptosis control","description":"The top GO terms point to regulatory roles across signaling pathways, especially positive regulation of canonical Wnt signaling, with additional cues from ERK, Hippo, and Rho pathway regulation. The inclusion of ubiquitin-dependent proteolysis via multivesicular body sorting and apoptotic process suggests coordinated control of signaling and cell fate through protein turnover. Put together, the proteins appear to function as regulators of signaling networks with a link to apoptosis.","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":4},{"id":"GO:0070373","count":3},{"id":"GO:0043162","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0060044","count":3}]},{"hash":"1190603252202796114","title":"ERK Signaling and Apoptosis Regulation","description":"The top terms show regulation of the ERK1/ERK2 cascade and the execution phase of apoptosis, plus several stress-response and defense-related terms, suggesting a core theme around signaling pathways that govern cell fate and stress responses, with some pleiotropic immune-related associations. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010667","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0030889","count":3},{"id":"GO:0032094","count":3},{"id":"GO:0030900","count":3}]},{"hash":"1081138330766596096","title":"Viral Entry and Replication","description":"This cluster shows several GO terms tied to viral processes, such as viral life cycle, proviral latency, fusion of the virus membrane with the host, and RNA-templated DNA biosynthesis, indicating a theme around virus-host interaction and replication. While there are also non-viral terms (lipid droplets, protein folding, etc.), the viral-related terms provide the strongest connecting thread. Confidence: Medium","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034389","count":2},{"id":"GO:0018279","count":2},{"id":"GO:0033617","count":1},{"id":"GO:0070131","count":1},{"id":"GO:0006457","count":1}]},{"hash":"259666121064887237","title":"Nephron and kidney tubule development","description":"The top GO terms cluster around metanephric/nephron development and tubule morphogenesis (distal/proximal tubules, ascending limb, mesonephric duct, kidney development), indicating a cohesive kidney/nephron morphogenesis theme; a couple of ancillary terms like cell adhesion and immune regulation do not override this main signal.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":2},{"id":"GO:0072287","count":2},{"id":"GO:0072237","count":2},{"id":"GO:0036303","count":2},{"id":"GO:0072218","count":2}]},{"hash":"1582914634775865807","title":"Meiosis and Cell Division Machinery","description":"The GO terms emphasize meiotic spindle assembly, chromosome alignment during meiosis, cell cycle and division, and bud neck septin ring organization, with supporting cues from ER polarization and ribosome biogenesis/export. Together they point to a module dedicated to meiosis and cell division processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0061163","count":3},{"id":"GO:0051311","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0032186","count":3}]},{"hash":"1432850847684259387","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034414","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0019243","count":1},{"id":"GO:0030420","count":1},{"id":"GO:0034247","count":1}]},{"hash":"872811265483583528","title":"Central carbon metabolism and energy production","description":"The GO terms cluster around glycolysis, the TCA cycle, and thiamine-dependent steps linking pyruvate to acetyl-CoA, all core components of central carbon metabolism and energy generation from carbohydrates. Additional terms for glycerol/propylene catabolism and detox responses suggest broader metabolic versatility, but the dominant signal is energy-producing carbon flow. ","confidence":"High","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":4},{"id":"GO:0006096","count":4},{"id":"GO:0006099","count":4},{"id":"GO:0061732","count":4},{"id":"GO:0055114","count":3}]},{"hash":"1149770008621023891","title":"Neurodevelopment and sensory organ formation","description":"The top GO terms cluster around brain development, inner ear development, neural fate and locomotory behavior, with related hindbrain patterning (rhombomere development). While there are some broader transcription/chromatin-related terms, the dominant theme is neural and sensory system development, suggesting these proteins function in neurodevelopment and sensory organ formation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0008584","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0048839","count":2}]},{"hash":"1225743663605897321","title":"COPI-Dependent ER\u2013Golgi Transport","description":"The cluster is dominated by GO terms tied to vesicle trafficking between the endoplasmic reticulum and the Golgi, including COPI-coated vesicles, COPI coating of Golgi vesicles, ER-to-Golgi transport, and Golgi ribbon formation, as well as regulation of protein exit from the ER and secretion (e.g., Wnt). These converge on a single theme: COPI-mediated ER\u2013Golgi trafficking and Golgi-related secretion. Some developmental or behavior terms appear peripherally but do not redefine the core function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001893","count":1},{"id":"GO:0035964","count":1},{"id":"GO:1902003","count":1},{"id":"GO:0090161","count":1},{"id":"GO:0048205","count":1}]},{"hash":"2107845242649474947","title":"Membrane Transporters for Small Molecules","description":"The top GO terms are dominated by various transmembrane transport activities across a wide range of substrates (aromatic compounds, glucose and trehalose, sialic acid, organic anions, selenite, potassium ions, etc.) and vesicle-associated transport such as neurotransmitter loading. This pattern strongly suggests a cluster of membrane transporter proteins with diverse substrate specificity. An outlier term related to replicative senescence appears incidental rather than indicative of a shared function. Confidence: Medium.","confidence":"","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":5},{"id":"GO:0098700","count":5},{"id":"GO:1904728","count":5},{"id":"GO:1904659","count":5},{"id":"GO:0015771","count":5}]},{"hash":"341670780721707065","title":"Diverse solute transporters","description":"The top GO terms are all related to transport across membranes for a variety of substrates (carbohydrates, sugar alcohols, organic anions, sialic acid, selenite, potassium ions, etc.), with one term referencing neurotransmitter loading into synaptic vesicles. This pattern points to a shared function as membrane transport proteins handling diverse solutes, rather than a single substrate or highly specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":1},{"id":"GO:0098700","count":1},{"id":"GO:1904728","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0015771","count":1}]},{"hash":"40009676143016886","title":"Neuronal morphogenesis and migration","description":"This cluster is centered on neuronal development processes, with GO terms for axon guidance, dendrite morphogenesis, and radial glial scaffold formation, as well as cytoskeletal remodeling (filopodium and stress fiber assembly) and adhesion-related migration. While there are a few broader adhesion terms, the dominant theme is neuronal morphogenesis and directed migration during CNS development.","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0051496","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0038027","count":2}]},{"hash":"68035562517887670","title":"Multi-tissue development","description":"The GO terms are dominated by development-related terms across various tissues (cerebral cortex, hippocampus, inner ear, keratinocyte differentiation, mammary gland epithelium). While there are some ancillary terms (cell cycle, signaling), the common theme is developmental processes across multiple organs, justifying a multi-tissue development label.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0021987","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0006977","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0021766","count":2}]},{"hash":"1200664853549842926","title":"Bacterial cell wall biosynthesis and antibiotic metabolism","description":"The top GO terms cluster around bacterial cell envelope and antibiotic-related processes: peptidoglycan biosynthesis, lipoteichoic acid biosynthesis, and antibiotic biosynthetic/metabolic processes, suggesting a theme of bacterial cell wall construction and antibiotic-related pathways. A few terms (paranode localization, plant pigment biosynthesis, estrogen catabolism) appear as outliers or annotation noise, but do not override the main bacterial biosynthesis signal. Confidence: Medium.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0016999","count":3},{"id":"GO:0009252","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0052697","count":3},{"id":"GO:0051301","count":3}]},{"hash":"1426067106186141870","title":"Developmental morphogenesis and cell interactions","description":"This cluster centers on terms tied to tissue development and morphogenesis (hair follicle development, lung morphogenesis, skeletal muscle satellite cell proliferation) and includes related cell-interaction processes (cell adhesion, engulfment and recognition of apoptotic cells). While metabolism-related terms appear, the dominant theme is developmental remodeling and intercellular signaling, suggesting a cohesive but broad developmental role for these proteins.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006541","count":2},{"id":"GO:0001942","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0007213","count":2}]},{"hash":"487163212947240565","title":"Neurodevelopment and Embryonic Heart Signaling","description":"The top terms point to neural development (peripheral nervous system neuron development, visual perception, paranode axon localization) and embryonic processes (primitive streak formation) plus heart development and NFAT signaling, suggesting a cluster centered on neuro- and cardiac developmental signaling. A few plant biosynthesis terms appear irrelevant noise. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048935","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0090009","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1382572606625676448","title":"Developmental signaling and muscle organization","description":"This cluster centers on signaling pathways (Wnt, PI3K/AKT, Rho, NFAT) and processes related to development, adhesion, and sarcomere organization, suggesting a theme of coordinating development with muscle tissue structure.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0051897","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0007275","count":2}]},{"hash":"660376649277051346","title":"Embryonic organ and tissue differentiation","description":"Most terms describe development or morphogenesis of multiple organs (kidney, heart, cerebellar neurons) and tissue organization, suggesting a cluster centered on embryonic tissue differentiation; some terms relate to regulatory processes that broadly influence development, such as gene silencing and immune homeostasis.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061205","count":2},{"id":"GO:0045216","count":2},{"id":"GO:0072283","count":2},{"id":"GO:0055011","count":2},{"id":"GO:0046013","count":2}]},{"hash":"527419185371524871","title":"Ubiquitination and Proteasomal Degradation","description":"Dominated by ubiquitin-related processes: neddylation, sumoylation, autoubiquitination, SCF-dependent tagging, and proteasomal degradation. These indicate regulation of protein turnover; a couple unrelated terms exist but do not change the core theme.","confidence":"High","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045116","count":2},{"id":"GO:0016925","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0031146","count":2}]},{"hash":"2020143962318036306","title":"Xenobiotic detoxification and oxidative stress response","description":"The proteins are enriched for detoxification-related GO terms, including cellular oxidant detoxification, xenobiotic catabolic processes, and nitrogen metabolism regulation, indicating a detoxification/stress-response functional theme. A weaker signal for oligodendrocyte development appears among the terms, but it does not dominate the cluster.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":5},{"id":"GO:0070458","count":4},{"id":"GO:0014003","count":4},{"id":"GO:0042994","count":4},{"id":"GO:0032720","count":4}]},{"hash":"1920007443916978056","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006605","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0000463","count":5},{"id":"GO:0000716","count":5},{"id":"GO:0070870","count":5}]},{"hash":"2080700387468988798","title":"Unknown","description":"The top GO terms span various metabolic pathways (methane, methanol, cholesterol, glycine betaine biosynthesis), oxidative stress response, and some development/immune processes (face development, fibroblast migration, IL-8 and inflammatory regulation). There is no clear single function linking these proteins, and the cluster lacks interactions, so a cohesive label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046188","count":1},{"id":"GO:0015945","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0008203","count":1},{"id":"GO:0019285","count":1}]},{"hash":"539482585190408777","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030307","count":2},{"id":"GO:0000395","count":2},{"id":"GO:0003149","count":2},{"id":"GO:0043045","count":2},{"id":"GO:0010452","count":2}]},{"hash":"165368403129388969","title":"Inhibitory receptor clustering and synapse maintenance","description":"The presence of GO terms for glycine receptor clustering, GABA receptor clustering, and maintenance of synapse structure strongly suggests a core theme of synaptic organization and inhibitory receptor assembly. The other terms (eye morphogenesis and molybdenum cofactor biosynthesis) appear as outliers or less-connected annotations, indicating the cluster is primarily about synaptic architecture with some unrelated annotations.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090051","count":2},{"id":"GO:2000222","count":2},{"id":"GO:0072579","count":1},{"id":"GO:0097112","count":1},{"id":"GO:0018315","count":1}]},{"hash":"309426614232591246","title":"Ciliogenesis and Wing Development","description":"The cluster\u2019s top GO terms center on motile cilium assembly, intraciliary retrograde transport, and microtubule anchoring at the centrosome, plus wing disc and imaginal disc-derived wing morphogenesis, suggesting a shared involvement of ciliary/centrosomal machinery in developmental morphogenesis. Some other terms (sperm individualization, oogenesis, neurogenesis) indicate broader development roles, while the antigen presentation term may be an annotation artifact; overall, the theme points to cytoskeletal/ciliary processes underpinning development. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007291","count":3},{"id":"GO:0035220","count":3},{"id":"GO:0044458","count":3},{"id":"GO:0048477","count":3},{"id":"GO:0035721","count":3}]},{"hash":"1278065691802430987","title":"Golgi-ER trafficking and retinoid metabolism","description":"The top GO terms strongly point to intracellular trafficking between the endoplasmic reticulum and Golgi (ER to Golgi transport; Golgi ribbon formation) and retinol metabolic processes, suggesting core roles in Golgi-ER transport and vitamin A/retinoid metabolism. Several developmental-related terms (genitalia morphogenesis, bladder development, photoreceptor differentiation) align with retinoid signaling\u2019s known influence on development, while other terms hint at broader cellular and neural signaling contexts. Overall, the cluster seems best described by a core theme of Golgi-ER trafficking with retinoid metabolism as a unifying thread.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000463","count":2},{"id":"GO:0048807","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0060044","count":2},{"id":"GO:0060157","count":2}]},{"hash":"2138354430596411658","title":"Histone modification and chromatin regulation","description":"Based on the prevalent GO terms, the proteins cluster around histone post-translational modifications (ubiquitination, acetylation, methylation) and related chromatin remodeling/catabolism processes, with links to cell-cycle\u2013related chromatin events (mitotic spindle checkpoint, transcriptional regulation during G2/M). This suggests a theme centered on epigenetic regulation of chromatin structure and function, rather than a single signaling pathway, hence the label.","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070535","count":3},{"id":"GO:2000620","count":3},{"id":"GO:0070512","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0033151","count":2}]},{"hash":"1384332065016711043","title":"NF-kB\u2013driven immune signaling","description":"Proteins in this cluster show enrichment for NF-kB-related signaling terms (canonical NF-kB activation, TNF-mediated signaling) and immune processes, including innate responses and T/B cell homeostasis. Ubiquitination and polyubiquitination terms suggest regulation of NF-kB signaling by ubiquitin pathways. The nervous system development term appears but likely reflects broader NF-kB roles; overall, the cluster centers on NF-kB\u2013mediated immune regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0045087","count":3}]},{"hash":"923783613208448318","title":"Embryonic Organogenesis","description":"These proteins are tied to development across multiple organs (harderian gland, trachea cartilage, ovarian follicle growth, prostate differentiation, cardiac morphogenesis) and include transcription-related processes (DNA-templated transcription, Pol II preinitiation regulation). The common theme is embryonic organ development and differentiation rather than a single, specific pathway, justifying the label Embryonic Organogenesis. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070384","count":3},{"id":"GO:0017055","count":3},{"id":"GO:0060534","count":3},{"id":"GO:0006351","count":3},{"id":"GO:2000020","count":3}]},{"hash":"2110707446826184103","title":"Unknown","description":"Top GO terms include diverse biosynthetic and metabolic processes (macrolide biosynthetic process; ecdysone biosynthetic process; progesterone metabolic process; bile acid biosynthetic process; retinoic acid catabolic process), environmental responses (response to ozone; response to cesium ion), immune regulation (negative regulation of chronic inflammatory response), and a maternal process term. The terms do not converge on a single cohesive function or pathway for the cluster, making a clear, representative label difficult to assign.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033068","count":5},{"id":"GO:0006697","count":5},{"id":"GO:0042448","count":5},{"id":"GO:0010193","count":5},{"id":"GO:0071615","count":5}]},{"hash":"1599156887341785440","title":"Endothelial and adipose tissue development","description":"Based on the prominent GO terms for endothelial cell migration and development and fat cell differentiation, along with triglyceride metabolism, the cluster appears to reflect development and differentiation of vascular and adipose tissues, likely moderated by PI3K/AKT signaling. Some other broad terms are present, but the core theme centers on endothelial and adipose tissue formation.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0006641","count":3},{"id":"GO:0043534","count":2},{"id":"GO:0001885","count":2},{"id":"GO:0045444","count":2}]},{"hash":"705463891458960789","title":"Actin dynamics and signaling in development","description":"The top GO terms point to actin cytoskeleton regulation (GTPase activity, barbed-end capping, Arp2/3 inhibition) alongside signaling processes (peptidyl-tyrosine phosphorylation, TGF-beta response) and developmental/neural contexts (synaptic plasticity, hippocampus development, leg segmentation). This suggests a theme of cytoskeletal remodeling tightly coupled to signaling during development and neural plasticity, with a few terms (ribosome biogenesis) as less-connected outliers.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050731","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0031915","count":3},{"id":"GO:0051016","count":3},{"id":"GO:0071560","count":3}]},{"hash":"1042406499621602923","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045216","count":2},{"id":"GO:0060901","count":2},{"id":"GO:0071681","count":2},{"id":"GO:0032533","count":2},{"id":"GO:0060989","count":2}]},{"hash":"2300513603459365684","title":"Proteostasis and stress responses","description":"The GO terms show a strong tilt toward protein turnover (ubiquitin-dependent catabolic process; proteasome regulatory particle assembly) and mRNA stability regulation, with additional signals of cellular stress responses (response to cold; response to vitamin D) and hepatocyte apoptosis, suggesting a cluster focused on proteostasis under stress and related quality-control pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0070427","count":2},{"id":"GO:0097284","count":2}]},{"hash":"1915255609898433642","title":"Ubiquitination and Chromatin Modification","description":"The GO terms cluster around post-translational modifications that regulate chromatin, notably autoubiquitination, histone ubiquitination (including H2A K63-linked ubiquitination), and deglutamylation, with supporting references to histone turnover. Although a few terms reference immune processes (V(D)J recombination, isotype switching), the common thread is chromatin-associated regulation via ubiquitin and related PTMs.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033151","count":1},{"id":"GO:0036205","count":1},{"id":"GO:1900095","count":1},{"id":"GO:0035609","count":1},{"id":"GO:0031030","count":1}]},{"hash":"986099537159691800","title":"Ubiquitin-Dependent Signaling Regulation","description":"The cluster is dominated by ubiquitination-related GO terms (monoubiquitination, K63-linked ubiquitination, autoubiquitination, and regulation of ubiquitin-dependent protein catabolic process) and includes terms related to signaling pathways (Wnt, ERK/JNK cascades) and developmental processes (placenta morphogenesis, mechanical signaling). This suggests proteins that modulate signaling pathways via ubiquitin-dependent regulation in development-related contexts.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000059","count":4},{"id":"GO:0060669","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0070534","count":4},{"id":"GO:0006513","count":3}]},{"hash":"1527017891331810605","title":"Nutrient-sensing neural signaling and ciliary transport","description":"The terms point to neural signaling and metabolism (TOR signaling, amino acid response, norepinephrine secretion, mushroom body development) combined with ciliary and vesicle dynamics (intraciliary transport, vesicle fusion/recycling). This suggests a theme of nutrient status modulating neural signaling and related ciliary/vesicle processes, though the small, disjoint set and zero interactions make the assignment tentative.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035735","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0071230","count":1},{"id":"GO:0032008","count":1},{"id":"GO:0016319","count":1}]},{"hash":"2021618887925088107","title":"Diverse Embryonic Tissue Development","description":"The top GO terms cover development and cell fate specification across multiple tissues (nervous system, brain regions, somites, pancreas, ureteric bud/kidney). The lack of protein\u2013protein edges suggests these proteins are associated with broad developmental roles rather than a single pathway, so a label reflecting a general embryonic development theme fits best.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021570","count":2},{"id":"GO:2000288","count":2},{"id":"GO:0060163","count":2},{"id":"GO:0021723","count":2},{"id":"GO:0001757","count":2}]},{"hash":"1869196861415064662","title":"N-terminal protein methylation","description":"The top GO terms are dominated by various N-terminal methylation activities (N-terminal peptidyl-glycine methylation, N-terminal peptidyl-serine/alanine methylation variants, and general methylation). This points to a common function as N-terminal methyltransferases acting on protein substrates. Other terms (ubiquitin-dependent degradation via MVB sorting and some biosynthetic processes) are less coherent with the main signal and may reflect annotation noise. Therefore, the cluster is best described as proteins involved in N-terminal protein methylation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043162","count":2},{"id":"GO:0018013","count":1},{"id":"GO:0051555","count":1},{"id":"GO:0035573","count":1},{"id":"GO:0030187","count":1}]},{"hash":"65980576032502384","title":"Rho-regulated cell junctions and polarity","description":"The top GO terms cluster around regulation of Rho signaling, localization to adherens and tight junctions, and basolateral membrane localization, suggesting a core role in cytoskeleton-driven junction formation and cellular polarity. Some terms touch on neuronal and immune processes, but the dominant theme remains junctional organization modulated by Rho pathways.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:2000670","count":5},{"id":"GO:0006470","count":5},{"id":"GO:0032416","count":4},{"id":"GO:0071896","count":4}]},{"hash":"383743770478491194","title":"Adherens junction signaling and cytoskeletal dynamics","description":"The top GO terms converge on cell adhesion at adherens junctions, cytoskeletal remodeling via Rho signaling, and junction-associated signaling including neurotransmitter receptor clustering and TRK pathway, with broader signaling cross-talk (p38MAPK, UPR, CDK activity). This suggests a cluster centered on junctional signaling and actin dynamics rather than a single enzymatic function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":2},{"id":"GO:0032416","count":2},{"id":"GO:0072578","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0045737","count":2}]},{"hash":"1688511703553933148","title":"NF-kappaB\u2013driven immune activation","description":"The terms are dominated by immune response and NF-kappaB\u2013related regulation (humoral immune response, IL-6 production, non-canonical NF-kappaB signaling, leukocyte adhesion, lymph node development), indicating a cluster of proteins involved in inflammatory immune signaling and cytokine regulation rather than a single enzymatic function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":1},{"id":"GO:0051092","count":1},{"id":"GO:0006959","count":1},{"id":"GO:0032755","count":1},{"id":"GO:0048535","count":1}]},{"hash":"1172534364007162727","title":"Neuronal development and synaptic signaling","description":"GO terms cluster around nervous system development, neuron maturation, and midbrain dopaminergic neuron differentiation, with several entries tied to GPCR signaling, synaptic structure modification, and endocytosis. Together these point to neural development and synaptic function as the core theme of the proteins, so this label captures their shared function. Some terms (phagophore assembly site localization and kidney size regulation) are broader or peripheral, but do not override the dominant neural-related signal.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0099563","count":5},{"id":"GO:0034497","count":5},{"id":"GO:0014041","count":5},{"id":"GO:0045792","count":5},{"id":"GO:0038027","count":5}]},{"hash":"33630367650531819","title":"Unknown","description":"The terms span brain and nervous system development, heart development, vesicle fusion with calcium-dependent exocytosis, plus plant ABA signaling and yeast pseudohyphal growth, indicating no single cohesive function for the cluster across species. Consequently, a specific label cannot be reliably assigned.","confidence":"","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0009789","count":3},{"id":"GO:0001302","count":3},{"id":"GO:0043547","count":3}]},{"hash":"2017931622726473099","title":"Developmental signaling and cell adhesion","description":"This cluster centers on development-related processes and signaling pathways, with multiple GO terms tied to morphogenesis and tissue development (bone, muscle, heart) and signaling (ERBB2-ERBB3, Wnt/JNK) alongside adhesion and cytoskeletal organization (microvillus organization, substrate adhesion-dependent spreading). The common theme is developmental signaling intertwined with cell-matrix/cell-cell interactions and EMT-related processes, rather than a single tissue or highly specific function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":1},{"id":"GO:0038031","count":1},{"id":"GO:0042220","count":1},{"id":"GO:0032528","count":1},{"id":"GO:0007275","count":1}]},{"hash":"91433929487475861","title":"Leukocyte Activation and Chemotaxis","description":"The terms cluster around immune cell behavior: neutrophil chemotaxis, T cell activation via antigen presentation, and heterophilic cell-cell adhesion, with filopodium assembly and Rho signaling reflecting cytoskeletal remodeling needed for movement and immune synapse formation. The inclusion of symbiont entry into host cell hints at host\u2013pathogen interactions during immune responses. Overall, these terms point to proteins involved in leukocyte activation, migration, and cell\u2013cell communication. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":3},{"id":"GO:0030593","count":3},{"id":"GO:0002291","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0046718","count":3}]},{"hash":"684289683570786385","title":"Mitotic division and nuclear reassembly","description":"The top GO terms are dominated by cell division, cell cycle, and mitosis-related processes (cell division, mitotic metaphase chromosome alignment), plus nuclear membrane reassembly, all pointing to mitotic/nuclear division functions. A couple terms like mRNA processing and membrane fission are peripheral but may reflect broader protein roles or annotation noise. Overall, the cluster appears centered on mitosis and nuclear events.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0000920","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0006997","count":1}]},{"hash":"93333108916266313","title":"Ubiquitin-Dependent Proteolysis and NF-\u03baB Signaling","description":"The cluster shows strong presence of ubiquitin-mediated protein catabolism and ubiquitination, plus regulation of canonical NF-\u03baB signaling and innate immune response terms, indicating a core theme around ubiquitin-proteasome\u2013driven protein turnover that modulates NF-\u03baB\u2013dependent immune signaling. Some cardiac action potential terms appear but do not define the main function. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0070301","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1696792083143630037","title":"Unknown","description":"The GO terms are highly diverse (estrogen response, inositol lipid signaling, immune chemotaxis, chromatin remodeling, sporulation membrane, myelin assembly, sterol biosynthesis, autophagosome regulation, egg activation) with no clear shared function or connectivity, so no cohesive label can be formed.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071391","count":1},{"id":"GO:0046856","count":1},{"id":"GO:0046855","count":1},{"id":"GO:0002233","count":1},{"id":"GO:0045815","count":1}]},{"hash":"566854157176097900","title":"RNA processing and translation machinery","description":"This cluster is dominated by RNA metabolism and protein synthesis terms\u2014splicing, mRNA stability, ncRNA-mediated silencing, ribosome biogenesis, and translation initiation/reinitiation\u2014indicating a cohesive theme around RNA processing and assembly of the translation apparatus. Some terms (lens differentiation, general cell division) are broader but do not override the central RNA/protein synthesis signal.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0051301","count":3}]},{"hash":"905067978779252020","title":"Actin-dependent vesicle transport and cell migration","description":"This cluster centers on processes tied to the actin cytoskeleton, including vesicle transport along actin filaments, pigment granule transport, and cell migration (fibroblast migration, substrate-dependent cell migration, cell extension). It also includes mitotic contractile ring actin filament bundle assembly and organelle inheritance, which reflect cytoskeletal roles during division. Some regulatory terms (hippo signaling, VEGF signaling) likely accompany these core processes but are not the defining theme. Overall, the shared thread is actin-dependent transport and motility.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030050","count":1},{"id":"GO:1903477","count":1},{"id":"GO:0051904","count":1},{"id":"GO:0035332","count":1},{"id":"GO:0010761","count":1}]},{"hash":"544545383986501771","title":"Glycan biosynthesis and epithelial polarity","description":"The top GO terms cluster around glycosylation processes (arabinogalactan protein metabolism, poly-N-acetyllactosamine biosynthesis, Lewis a epitope biosynthesis, mucilage biosynthetic processes, O-linked glycosylation) and epithelial polarity/adhesion (follicle cell adhesion, maintenance of polarity of follicular epithelium). This points to proteins involved in modifying cell-surface glycans that influence cell\u2013cell adhesion and tissue polarity during development. Some terms are plant-specific, but the common thread is glycan biosynthesis linked to cell-surface properties.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007299","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0001744","count":2},{"id":"GO:0030311","count":2},{"id":"GO:0010493","count":2}]},{"hash":"250960972044711339","title":"Eye development and visual perception","description":"These terms collectively point to vision-related biology, especially photoreceptor differentiation and visual perception; endosome to melanosome transport supports ocular pigment cell biology. While other terms refer to signaling pathways, the strongest theme is eye/photoreceptor function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":1},{"id":"GO:2000145","count":1},{"id":"GO:0035646","count":1},{"id":"GO:1900746","count":1},{"id":"GO:1901223","count":1}]},{"hash":"141604475734920635","title":"Polyamine biosynthesis and transport","description":"This cluster's top GO terms cluster around polyamine production (putrescine, spermidine) and its transport, with multiple explicit biosynthetic steps and a transport regulation term. While there are a couple outliers like trans-Golgi network organization and kidney development, the central theme is polyamine metabolism and membrane transport.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098629","count":3},{"id":"GO:0033387","count":3},{"id":"GO:0045312","count":3},{"id":"GO:0008295","count":3},{"id":"GO:0001822","count":3}]},{"hash":"463979772921008400","title":"Glycosylation and carbohydrate metabolism","description":"The proteins cluster around carbohydrate processing and glycan modification, including glycosphingolipid biosynthesis, various glycosylation-related processes, and general carbohydrate metabolic activities (glycolytic and fructose metabolism). While a few terms (like leukotriene biosynthesis and glutathione turnover) are peripheral, the dominant theme is glycoconjugate formation and sugar metabolism, suggesting a coherent role in glycan biosynthesis and energy/carbon flux through carbohydrate pathways.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033580","count":1},{"id":"GO:0030259","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0006688","count":1},{"id":"GO:0006508","count":1}]},{"hash":"2065872332978778686","title":"Notch/Wnt Developmental Signaling","description":"The cluster prominently includes GO terms for Notch signaling and positive regulation of canonical Wnt signaling, along with imaginal disc-derived leg joint morphogenesis, which collectively point to developmental signaling pathways. Other terms like antiviral response and ubiquitination appear only modestly and may reflect additional, multifunctional roles of the proteins, but the core linkage is developmental signaling via Notch and Wnt pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901315","count":1},{"id":"GO:0071360","count":1},{"id":"GO:0045071","count":1},{"id":"GO:0034389","count":1},{"id":"GO:0090263","count":1}]},{"hash":"838879160937372543","title":"SNARE-Mediated Vesicle Trafficking and Receptor Insertion","description":"The GO terms cluster around SNARE complex assembly, intra-Golgi and ER-Golgi transport, vesicle fusion, and Golgi organization, together with exocytic insertion of neurotransmitter receptors and synaptic plasticity (long-term potentiation). This points to a cohesive function in SNARE-driven vesicle trafficking and delivery of receptors to the synapse, with vesicle trafficking also supporting receptor recycling. ","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001921","count":2},{"id":"GO:0071284","count":2},{"id":"GO:0043312","count":2},{"id":"GO:0098967","count":2},{"id":"GO:0060291","count":2}]},{"hash":"522990604620626508","title":"Ubiquitination and Proteasomal Degradation","description":"The top GO terms are strongly centered on ubiquitination and proteasome-driven protein turnover (polyubiquitination, SCF-dependent degradation, ERAD-related pathways, and deubiquitination). Development-related terms appear as secondary associations, suggesting roles in development through proteostasis. This makes \"Ubiquitination and Proteasomal Degradation\" a representative and specific label for the cluster.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0071276","count":2}]},{"hash":"1208368290718285954","title":"Mitotic spindle dynamics and chromosome alignment","description":"This cluster is dominated by GO terms related to microtubule-based mitosis, including spindle assembly, kinetochore-microtubule attachments, metaphase chromosome alignment, and plus-end microtubule depolymerization. Some terms reflect broader plant development processes (root development, chloroplast movement) or stem cell homeostasis, but the central theme across terms is spindle organization and chromosome segregation during cell division.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0036334","count":4},{"id":"GO:0000742","count":4},{"id":"GO:0048364","count":4},{"id":"GO:0007080","count":4},{"id":"GO:0009904","count":4}]},{"hash":"1505482304139482277","title":"Unknown","description":"The terms span vascular development (blood vessel morphogenesis, lymphangiogenesis) and calcium signaling (NFAT and postsynaptic calcium) as well as EMT, but also encompass RNA Pol II transcription termination and kinetochore localization, yielding no single cohesive function to bind the cluster.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070940","count":4},{"id":"GO:0034501","count":4},{"id":"GO:0001569","count":4},{"id":"GO:0001946","count":4},{"id":"GO:0051531","count":4}]},{"hash":"2020284889229364963","title":"Immune-ECM Interaction","description":"Top GO terms cluster around immune processes (T cell activation, complement activation, ubiquitin-dependent protein catabolic process, cellular extravasation) and extracellular matrix remodeling (hyaluronan metabolic process, negative regulation of ECM assembly). This points to a theme of immune signaling intertwined with ECM dynamics, potentially reflecting tissue infiltration and remodeling. A few terms (dendrite regeneration, light detection, stamen formation) appear as outliers, but do not dominate the set.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030212","count":3},{"id":"GO:0002291","count":3},{"id":"GO:1901202","count":2},{"id":"GO:0031104","count":2},{"id":"GO:0048455","count":2}]},{"hash":"2032466400630837766","title":"Ubiquitin-Mediated NF-kB Immune Signaling","description":"This cluster centers on protein ubiquitination and regulation of NF-kB signaling, with multiple terms referring to positive/negative regulation of NF-kB and related pathways (Toll signaling, NOD2 signaling) and immune-related outputs such as IL-13 production, plus apoptosis. A few terms (like mitotic spindle assembly) appear less connected and may reflect broader cellular roles or annotation noise, but the dominant theme is ubiquitin-dependent control of NF-kB\u2013mediated immune responses.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0051092","count":3},{"id":"GO:0008588","count":3}]},{"hash":"1888942825656502149","title":"Sterol and isoprenoid biosynthesis","description":"The proteins are enriched for ergosterol and cholesterol biosynthesis, as well as the mevalonate pathway and farnesyl diphosphate biosynthesis, pointing to a shared role in sterol/isoprenoid metabolism. Acetyl-CoA metabolism also aligns as a common precursor supply. Some linked terms (iron-sulfur cluster assembly, nitrogen fixation, low light response) appear unrelated to this core function, suggesting annotation noise or multifunctionality, but the dominant theme is sterol/isoprenoid biosynthesis.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006696","count":1},{"id":"GO:0070317","count":1},{"id":"GO:0010142","count":1},{"id":"GO:0006084","count":1},{"id":"GO:0009645","count":1}]},{"hash":"1062153858106785787","title":"Retinal development and photoreceptor signaling","description":"The top GO terms point to sensory/eye-related processes, including photoreceptor cell differentiation and sensory perception, along with pigment-related transport and signaling pathways (Notch, VEGF, NF-kappaB) that are commonly involved in ocular development and photoreceptor function. With only four proteins and a mix of terms, this label best captures the strongest, coherent theme around eye/retina biology, though confidence is limited by the small cluster size and term diversity.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0042254","count":1},{"id":"GO:0032147","count":1},{"id":"GO:0045747","count":1},{"id":"GO:2000145","count":1}]},{"hash":"3731169544710995","title":"Nucleolar ribosome biogenesis","description":"The cluster's top GO terms center on nucleolus organization and ribosome biogenesis, indicating involvement in ribosome production within the nucleolus; the single kinase activation term is less defining but may reflect regulatory signaling linked to ribosome assembly.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007000","count":3},{"id":"GO:0042254","count":1},{"id":"GO:0032147","count":1}]},{"hash":"1439642085612427343","title":"Unknown","description":"These four proteins map to a broad mix of GO terms spanning nucleotide metabolism (guanine), various catabolic processes (D-alanine, glycerol), folate interconversion, stress responses (cold, ethanol, xenobiotic), and developmental terms (cerebral cortex, pituitary gland). The absence of a clear, single functional theme across the cluster makes it difficult to assign a confident, concise label.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046098","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0055130","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0055114","count":2}]},{"hash":"2031292486446364391","title":"Viral entry, replication, and latency","description":"The top GO terms cluster around viral infection processes: viral life cycle, fusion of viral membrane with host, host-mediated activation of viral genome replication, and RNA-templated DNA biosynthetic process (reverse transcription) with possible proviral integration and latency. While a couple of terms like lipid droplet organization and sepal formation seem unrelated and likely noise, the dominant theme points to host-virus interaction and stages of viral entry, genome replication, and latency. Therefore, the cluster best fits a viral infection/latency theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007165","count":1},{"id":"GO:0006457","count":1},{"id":"GO:0034389","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0006278","count":1}]},{"hash":"927736496095986811","title":"Stress Response and Protein Quality Control","description":"The cluster shows GO terms for heat acclimation, autophagy-related processes (mitophagy, aggrephagy), chaperonin/tubulin folding, and protein localization to the nuclear pore, along with transcription regulation by RNA polymerase II and DNA repair. Together these terms point to a group of proteins involved in managing cellular stress, maintaining proteome integrity, coordinating transcription, and regulating nuclear transport, rather than a single, narrow function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010286","count":4},{"id":"GO:0048936","count":4},{"id":"GO:0090204","count":4},{"id":"GO:0006357","count":4},{"id":"GO:0070911","count":4}]},{"hash":"1266682761358410966","title":"Mitochondrial translation and respiration","description":"The GO terms are centered on mitochondrial energy metabolism (TCA cycle and respiratory electron transport chain) and mitochondrial protein synthesis (mitochondrial tRNA aminoacylation and regulation of translational fidelity). This suggests a coherent cluster of components involved in mitochondrial energy production and the mitochondrion-specific translation system. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0022904","count":2},{"id":"GO:0070584","count":2},{"id":"GO:0097056","count":2}]},{"hash":"320513067283682415","title":"Organelle protein trafficking and stress response","description":"Most terms point to import and insertion of proteins into organelles (peroxisomes, mitochondria), coupled with proteostasis and trafficking (proteasome assembly, SNARE disassembly) and stress responses that tie into cell cycle regulation. This suggests a cohesive theme around organelle protein handling and cellular stress management.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0016558","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0034599","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0090296","count":3}]},{"hash":"912216957705667656","title":"Unknown","description":"The Top Terms are scattered across unrelated biological processes, including chlorophyll metabolism, skin differentiation, nitric oxide production, ergosterol regulation, nitrate assimilation, myelin maintenance, hypochlorite response, amino acid/metal metabolism, and protein repair, with no clear shared function or pathway. There are no edges or connectivity to suggest a cohesive cluster theme, so a specific functional label cannot be inferred. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015994","count":1},{"id":"GO:0001949","count":1},{"id":"GO:0006809","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0006790","count":1}]},{"hash":"828947011395325801","title":"Neural development and GPCR-MAPK signaling","description":"The GO terms cluster around brain development, neuronal processes, GPCR signaling, and MAPK cascades (ERK/JNK), with related migration activities (pseudopodium assembly, chemotaxis). There are also xenobiotic response signals, suggesting broader stress-response signaling contexts. Overall, the group points to signaling networks guiding neural development and cellular movement, with MAPK pathways as a central thread.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002551","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0007186","count":3},{"id":"GO:0031274","count":3},{"id":"GO:0070374","count":3}]},{"hash":"2119298877496978385","title":"NF-\u03baB\u2013mediated inflammatory signaling","description":"The top GO terms cluster around innate immune signaling and cytokine regulation, notably I-kappaB phosphorylation and MyD88-dependent Toll-like receptor signaling, plus negative regulation of JAK-STAT signaling and production of IL-6 and IL-18, which point to NF-\u03baB\u2013driven inflammatory pathways. There are a few terms related to actin filament remodeling and neuron maturation, suggesting some multifunctionality, but the dominant theme is inflammatory signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905289","count":1},{"id":"GO:0051639","count":1},{"id":"GO:2000172","count":1},{"id":"GO:0032741","count":1},{"id":"GO:0035751","count":1}]},{"hash":"232893617779347841","title":"Multilineage differentiation","description":"This cluster centers on the differentiation of cells into various lineages. Several GO terms point to skeletal lineages (osteoblast fate, chondrocyte differentiation, cranial skeleton morphogenesis) and immune lineages (T cell differentiation, granulocyte differentiation), while other terms reflect developmental processes such as imaginal disc and germ-band extension. Taken together, the proteins appear to participate in diverse differentiation programs rather than a single pathway, supporting a general multilineage differentiation theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901522","count":4},{"id":"GO:0045879","count":2},{"id":"GO:0007486","count":2},{"id":"GO:0030217","count":2},{"id":"GO:0048701","count":2}]},{"hash":"1009351800497010507","title":"DNA Transcription Regulation and Development","description":"This cluster is dominated by GO terms for DNA-templated transcription and transcription regulation by RNA polymerase II, plus an initiation term at the mitochondrial promoter, indicating a core role in transcription control. The additional one-off terms point to developmental differentiation processes, suggesting these proteins may link transcription regulation with developmental pathways. Overall, the theme is coherent but the developmental terms are less central, so the label is moderately confident.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006391","count":2},{"id":"GO:0070318","count":1},{"id":"GO:0060517","count":1}]},{"hash":"1485266468213007655","title":"SnoRNA/snoRNP biogenesis and telomerase RNA processing","description":"The GO terms point to RNA processing and maturation: box H/ACA snoRNP assembly, snRNA pseudouridine synthesis, snoRNA-guided rRNA pseudouridylation, snRNA transcription, telomerase RNA stabilization and holoenzyme assembly, and localization to Cajal bodies, all indicating a shared theme of nuclear RNA biogenesis and modification. Some peripheral terms for endothelial barrier and hemocyte proliferation appear unrelated to this core RNA-processing theme. ","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000493","count":1},{"id":"GO:0090669","count":1},{"id":"GO:0031120","count":1},{"id":"GO:1905323","count":1},{"id":"GO:0042254","count":1}]},{"hash":"599960313342883674","title":"Actin Cytoskeleton Dynamics and Cell Migration","description":"The top GO terms center on actin filament polymerization, actin nucleation, and related cytoskeletal remodeling, with accompanying hints of cell movement and development. Although some terms are obsolete, the dominant pattern points to actin dynamics driving cell migration and tissue development.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":1},{"id":"GO:0045010","count":1},{"id":"GO:0048875","count":1},{"id":"GO:2000402","count":1},{"id":"GO:0007275","count":1}]},{"hash":"1027986203763237776","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":2},{"id":"GO:1990258","count":1},{"id":"GO:0006356","count":1},{"id":"GO:0000494","count":1},{"id":"GO:0008033","count":1}]},{"hash":"398636088204630924","title":"Redox Homeostasis and Mitochondrial Metabolism","description":"The cluster is dominated by GO terms related to maintaining cellular redox balance and detoxifying oxidants, along with regulation of mitochondrial membrane potential and organelle-related pH (vacuolar acidification). A metabolic thread is supported by homogentisate catabolic process. Some unrelated terms (cytokinin response, osteoblast differentiation) appear as noise, but the core theme ties to redox regulation and energy/metabolism.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0051881","count":2},{"id":"GO:1902000","count":2},{"id":"GO:1902476","count":2}]},{"hash":"1682666386857079822","title":"Unknown","description":"The top terms are a mix of diverse transport and metabolic/regulatory processes (ceramide translocation, bile acid secretion, chloride transport, peptide antigen/pheromone transport, fenofibrate response, cholesterol absorption), plus assembly and stress/immune-related terms, with no single unifying function or strong interactions linking the proteins. This lack of a clear common theme justifies labeling the cluster Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902161","count":4},{"id":"GO:0099040","count":4},{"id":"GO:0045796","count":4},{"id":"GO:0032782","count":4},{"id":"GO:1902476","count":4}]},{"hash":"942658748529416611","title":"Neural adhesion and myelination regulators","description":"The proteins show themes of cell\u2013cell adhesion, myelination and nerve maturation in the peripheral nervous system, as well as membrane proteolysis that can regulate adhesion and signaling. While immune-related terms are present, the core pattern points to adhesion/membrane remodeling roles in neural development and myelination. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":3},{"id":"GO:2000391","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0006509","count":2},{"id":"GO:0010765","count":2}]},{"hash":"162304326850776016","title":"Neural ion transport and calcium homeostasis","description":"The top GO terms cluster around intracellular ion homeostasis for Ca2+, Na+, K+, and Mn, plus calcium transport between cytosol and endoplasmic reticulum and sodium export. Although one term mentions vestibulocochlear nerve formation, the dominant theme is ion transport and homeostasis in neural contexts, especially calcium signaling. This makes \"Neural ion transport and calcium homeostasis\" a concise, representative label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021650","count":2},{"id":"GO:0002028","count":2},{"id":"GO:1901205","count":2},{"id":"GO:0006874","count":2},{"id":"GO:0030007","count":2}]},{"hash":"1126360235957780118","title":"Unknown","description":"The GO terms span chromatin-related acetylation (subtelomeric heterochromatin formation; N-terminal and histone H4 acetylation) and a diverse set of metabolic and plant-specific processes (glucosamine and arginine biosynthesis, mycothiol biosynthesis, melatonin biosynthesis, acetoin and putrescine catabolism, leaf formation regulation). There is no single unifying function linking all terms, so a cohesive label is not justifiable.","confidence":"","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006044","count":3},{"id":"GO:0010125","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0017196","count":3},{"id":"GO:0009447","count":3}]},{"hash":"549668920093687784","title":"Ubiquitin-Dependent Degradation and Autophagy Regulation","description":"Several top GO terms center on ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process, protein monoubiquitination) and autophagy-related substrate localization to autophagosomes, suggesting the proteins in this cluster are linked to ubiquitin-dependent degradation and autophagy pathways. Other terms (cytokinesis regulation, tRNA processing, neuronal apoptosis modulation) are supplementary, reflecting broader cellular roles. Thus the label captures the primary theme with some functional diversity.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051260","count":2},{"id":"GO:0032465","count":2},{"id":"GO:2000235","count":2},{"id":"GO:0006513","count":2}]},{"hash":"276986950461003414","title":"Neuronal signaling and sensory perception","description":"The top GO terms are dominated by neural and sensory processes (sensory perception of pain, dopaminergic synaptic transmission, visual perception/learning, behavioral response to cocaine) and signaling pathways (ERK cascade), pointing to a cluster enriched for neuronal signaling and sensory processing. A couple of terms (heart development, macrophage chemotaxis) are less typical for neurons, suggesting broader or pleiotropic roles or annotation noise. Overall, the theme is neural signaling linked to perception and behavior.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0001963","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0048148","count":2},{"id":"GO:0071380","count":2}]},{"hash":"883279460503754922","title":"Calcium/NFAT signaling in EMT and vascular development","description":"Top terms cluster around calcium-dependent signaling (regulation of calcineurin-NFAT, postsynaptic calcium) and processes like epithelial-to-mesenchymal transition and vascular morphogenesis, suggesting a theme of calcium-regulated differentiation and cell movement in development. Some RNA Pol II-related terms appear as noise, but the core motif centers on calcium/NFAT\u2013mediated signaling in EMT and vascular contexts.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070940","count":2},{"id":"GO:0034501","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0001946","count":2},{"id":"GO:0051531","count":2}]},{"hash":"332101925467377355","title":"Autophagy and mitophagy regulation","description":"The strongest signals in this cluster are autophagy-related: mitophagy and aggrephagy, along with related membrane trafficking and vesicle formation terms. This suggests a group centered on selective degradation pathways and mitochondrial quality control, with secondary terms possibly reflecting multifunctional proteins involved in transcription or ribosome maturation but not defining the core theme. Confidence reflects a clear autophagy focus but some noise from other processes. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006357","count":4},{"id":"GO:0010637","count":4},{"id":"GO:0000423","count":4},{"id":"GO:0035973","count":4},{"id":"GO:0002109","count":4}]},{"hash":"2225255945054412230","title":"Embryonic development and transcriptional regulation","description":"The top GO terms point to gene regulation during development (negative regulation of transcription, histone-related processes) along with multiple embryonic patterning processes (syncytial blastoderm cell cycle, rostrocaudal neural tube patterning, eye morphogenesis, adaxial/abaxial patterning). This suggests a cluster of proteins involved in controlling developmental gene expression and pattern formation. A few terms are developmentally broad or outliers (e.g., V(D)J recombination), but the dominant theme is embryonic development coupled with transcriptional regulation.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0035186","count":3},{"id":"GO:0033151","count":2},{"id":"GO:0036205","count":2},{"id":"GO:0048593","count":2}]},{"hash":"381445872650323092","title":"Circadian Transcription Regulators","description":"This cluster is dominated by GO terms for DNA-templated transcription and circadian regulation of gene expression (DNA-templated transcription, regulation of DNA-templated transcription, circadian regulation of gene expression, and positive regulation of circadian rhythm). These terms indicate the proteins function as transcriptional regulators tied to circadian timing. Some developmental terms appear as broader regulatory roles, but the core signal points to circadian transcription control. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0032922","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0042753","count":2},{"id":"GO:0001701","count":2}]},{"hash":"1134610022029097026","title":"Unknown","description":"The GO terms span diverse processes, including arsenic response, peptidyl-tyrosine dephosphorylation, cell septum assembly, conjugation, glucose catabolism, cell cycle, ribosomal subunit biogenesis, and stress-related regulations, with several obsolete terms. The lack of a common, cohesive function and no interactions (Edges 0) make it impossible to assign a precise, representative label to the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0052046","count":1},{"id":"GO:0046685","count":1},{"id":"GO:0035335","count":1},{"id":"GO:0090529","count":1},{"id":"GO:0000747","count":1}]},{"hash":"1939355843796803780","title":"APC-dependent mitotic proteolysis","description":"Top GO signals emphasize mitotic cell cycle and APC-dependent proteolytic processes, pointing to a cluster centered on ubiquitin\u2011mediated protein degradation during cell division. Some terms appear ancillary (cadmium response, skeletal morphogenesis), but the dominant pattern supports mitotic regulation and proteolysis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902564","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0007338","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1876183805002855961","title":"Developmental gene regulation and differentiation","description":"This cluster combines GO terms for DNA-templated transcription, miRNA transcription regulation, and multiple differentiation processes (gastrulation, lens fiber cell differentiation, cartilage and erythrocyte differentiation), along with TGF-beta2 production regulation. The shared theme is regulation of developmental programs and lineage specification across various tissues, rather than a single pathway.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0001702","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0032909","count":2},{"id":"GO:1902895","count":2}]},{"hash":"2287534406934374535","title":"Retinal photoreceptor differentiation and melanosome transport","description":"The top GO terms strongly point to eye biology: visual perception and camera-type eye photoreceptor cell differentiation, plus endosome to melanosome transport, which implicates pigment-containing cells in the retina. Additional terms about Notch and VEGF signaling fit retinal development and vascularization, reinforcing a coherent theme of retinal differentiation and pigment trafficking. Some terms are broader, but the dominant visual/melanosome transport signals justify a retina-focused label.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":2},{"id":"GO:2000145","count":2},{"id":"GO:0035646","count":2},{"id":"GO:1900746","count":2},{"id":"GO:1901223","count":2}]},{"hash":"580503822903862683","title":"Neural development and locomotion","description":"The top GO terms cluster around brain development, sensory perception of sound, and locomotory behavior, indicating neural development and movement-related functions. Additional terms for Rho signaling regulation and nucleus organization suggest linked cytoskeletal and gene-regulatory processes in neural cells.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0035023","count":1},{"id":"GO:0003209","count":1}]},{"hash":"1953748976932051947","title":"Development and Chromatin Regulation","description":"The cluster combines terms tied to chromatin dynamics and transcription control (nucleus organization, chromosome condensation, histone modification, and RNA polymerase II\u2013dependent transcription) with diverse developmental processes (spermatid development, oogenesis, cardiac atrium morphogenesis, B cell differentiation). This suggests proteins that influence gene expression during development through chromatin remodeling and nuclear regulation, with an accompanying signaling context (Rho regulation).","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0003209","count":3},{"id":"GO:0033128","count":3},{"id":"GO:0043486","count":3}]},{"hash":"2099889757960672970","title":"Male germline development and histone acetylation","description":"This cluster centers on male germline development features (seminiferous tubule development, male meiosis I, asymmetric division of male germ-line stem cells) and chromatin regulation via histone H4 acetylation, plus links to transcription regulation and DNA damage response. The convergence of germline developmental processes with histone modification and stress response suggests a cohesive module governing male germ cell formation, meiosis, and genomic safeguarding.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072520","count":4},{"id":"GO:0043981","count":4},{"id":"GO:2000873","count":4},{"id":"GO:0048133","count":4},{"id":"GO:0061408","count":4}]},{"hash":"1504475119487871350","title":"Immune Activation and Inflammation","description":"The top GO terms point to both adaptive and innate immune processes, including T cell receptor signaling, neutrophil chemotaxis, monocyte differentiation, and cellular responses to LPS and GM-CSF, indicating activation and recruitment of leukocytes during immune responses. A couple of non-core terms (e.g., a fungal development term) appear as noise, but the dominant pattern is immune signaling and inflammation.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0048837","count":2}]},{"hash":"753326939397594273","title":"Unknown","description":"The GO terms are broad and heterogeneous, covering developmental signaling (Wnt), tissue development and remodeling (exocrine pancreas development, biomineral/tissue development, elastin catabolic process, smooth muscle migration), hemostasis (blood coagulation, fibrinolysis), and even immune and metabolic signals (neutrophil-mediated killing of fungus, cellular response to glucose). There is no single cohesive function or pathway tying all four proteins together, and the lack of edges suggests no direct interaction pattern to anchor a specific label. Therefore, a specific, representative name cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0014909","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0042730","count":3}]},{"hash":"1495805254587574242","title":"Neuronal development and presynaptic signaling","description":"Top GO terms point to brain development, presynaptic signaling, calcium response, and dense core granule exocytosis, suggesting neural differentiation and neurotransmitter release processes. While several broader cellular terms appear (autophagy, tRNA processing, transcription by RNA polymerase I), the prominent neural and synaptic signals support this theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0038028","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0045943","count":3},{"id":"GO:0071277","count":3}]},{"hash":"363587532975572853","title":"Vascular development and growth signaling","description":"This cluster centers on angiogenesis and vascular signaling, highlighted by GO terms for positive regulation of angiogenesis, VEGF receptor signaling pathway, and positive regulation of PI3K/AKT signaling. The presence of development-related terms like branching involved in mammary gland duct morphogenesis and organ regeneration supports a vascular-growth theme, while terms such as cellular response to retinoic acid and lipopolysaccharide signaling may reflect broader signaling context. Overall, the proteins are best described as participating in vascular development and growth signaling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045071","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0051897","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0071300","count":4}]},{"hash":"1769057722703981972","title":"Neural development and ciliary signaling","description":"The GO terms cluster around nervous system development, synaptic vesicle budding, and ciliary localization, with related signaling pathways (Smoothened/Hedgehog and EGFR) also represented. While kidney development appears, the dominant theme is neural development linked to vesicular trafficking and ciliary signaling, making this label representative of the group.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":3},{"id":"GO:0021762","count":2},{"id":"GO:0034497","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0070142","count":2}]},{"hash":"248943451656825167","title":"Iron uptake and detoxification","description":"The proteins in this cluster show strong ties to iron handling: siderophore-mediated iron import, iron ion transport, and detoxification of iron, with accompanying stress response and redox-related regulation (e.g., activation of enzymes tied to iron-containing cofactors). While a few terms are obsolete or unrelated, the predominant theme is iron acquisition and homeostasis under stress.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904234","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0033214","count":2},{"id":"GO:0006880","count":2},{"id":"GO:1990461","count":2}]},{"hash":"1825963573919623691","title":"Golgi- and SNARE-mediated neuronal vesicle trafficking","description":"The top GO terms cluster around Golgi-to-ER/Golgi vesicle transport, Golgi ribbon formation, SNARE complex assembly, vesicle fusion, and exocytic insertion of neurotransmitter receptors at the postsynaptic membrane, alongside synaptic potentiation and norepinephrine secretion. This points to a coherent role in neuronal vesicle trafficking coordinated by SNAREs and Golgi processes, including receptor delivery to the synapse and mechanisms of synaptic plasticity.","confidence":"High","size":4,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098967","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0006891","count":2},{"id":"GO:0090161","count":2},{"id":"GO:0048280","count":2}]},{"hash":"2128466417444068466","title":"Eye development and phototransduction","description":"The GO terms cluster around eye/visual processes (phototransduction, retina development, visual perception) and related development terms, suggesting the proteins function together in vision-related pathways. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007602","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0007275","count":2}]},{"hash":"70065583076486033","title":"KIT Signaling in Neural-Immune Development","description":"The dominant term is KIT signaling pathway, with multiple immune-related terms (Fc receptor signaling, neutrophil clearance, myeloid progenitor differentiation) and nervous-system terms, suggesting a cluster centered on KIT-mediated signaling with neural and immune development connections.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038109","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0097350","count":4},{"id":"GO:0007417","count":4},{"id":"GO:0070374","count":4}]},{"hash":"2198084511653742298","title":"Keratinocyte differentiation and epithelial junction assembly","description":"The terms point strongly to skin/epidermal biology: hair follicle morphogenesis, keratinization, establishment of epithelial cell polarity, and tight junction/adhesion-related processes. Additional terms like filopodium and ruffle assembly and endocytosis reflect cytoskeletal remodeling and vesicle trafficking involved in adhesion and polarity; a neuronal plasticity term is present but not central. Overall, the cluster seems to represent epidermal differentiation with emphasis on cell adhesion and junction formation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":2},{"id":"GO:0031424","count":2},{"id":"GO:0036089","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0070830","count":2}]},{"hash":"1405122991684908579","title":"Cell Migration and Adhesion Regulation","description":"This cluster centers on cytoskeletal dynamics and cell movement, as shown by regulation of Rho signaling, positive regulation of fibroblast migration and substrate adhesion-dependent cell spreading, and related development processes like heart and placenta formation. While some terms involve broader development, the predominant theme ties to how cells move and adhere, driven by signaling pathways that reorganize the cytoskeleton. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0007507","count":3},{"id":"GO:1900026","count":2}]},{"hash":"1836832874332499934","title":"Immune signaling and leukocyte activation","description":"The top GO terms point strongly to immune-related processes: cellular response to lipopolysaccharide, cellular response to GM-CSF stimulus, and T cell receptor signaling, plus regulation of leukocyte chemotaxis. These suggest activation and signaling in immune cells. While there are generic terms like DNA-templated transcription and a few outliers (ovulation, Kit signaling), the dominant theme is immune cell signaling and response. Given the small cluster size and partial term diversity, this label is a best-fit.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0048679","count":3}]},{"hash":"165951440472790784","title":"Cardiovascular Regulation and Platelet Activation","description":"The top GO terms cluster around regulation of cardiac muscle contraction, blood pressure, and platelet activation, indicating a shared role in cardiovascular signaling and platelet function. Other terms like response to electrical stimulus and bleb assembly reflect broader signaling and cytoskeletal dynamics but do not outweigh the cardiovascular/platelet theme. Therefore, this label captures the core function of the cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0070230","count":2},{"id":"GO:0055117","count":2},{"id":"GO:0030168","count":2}]},{"hash":"1260719146383378907","title":"Heat-induced chaperone activity and protein refolding","description":"The top GO terms cluster around protein folding and heat response, including chaperone-mediated protein complex assembly and protein refolding, along with a general response to heat. This points to a cohesive theme of heat-shock/chaperone\u2013driven maintenance of protein structure under stress. Some other terms (scaRNA localization, immune response, cocaine response) are more peripheral, likely reflecting broader stress or signaling contexts in the dataset, but do not contradict the central folding/heat theme.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051131","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0090666","count":3},{"id":"GO:1903427","count":3}]},{"hash":"1162754352887841597","title":"Unknown","description":"The top GO terms describe widely disparate processes (apoptotic signaling, epithelial proliferation, rRNA processing, splicing, ubiquitination, growth hormone response, kinase activity, and general cellular processes), with no coherent biological theme tying the proteins together.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001235","count":1},{"id":"GO:0060770","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0000463","count":1}]},{"hash":"352794851841794865","title":"Neural development and axon guidance","description":"This cluster centers on neural development processes such as neurogenesis, axonogenesis, axon regeneration, dendrite self-avoidance, and neuron migration, including photoreceptor differentiation. While a couple of terms touch on immune signaling or non-neural differentiation, the dominant pattern is neural development and axon/dendrite patterning, justifying the label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001751","count":2},{"id":"GO:0070593","count":2},{"id":"GO:0035457","count":2},{"id":"GO:0021836","count":2},{"id":"GO:1904238","count":2}]},{"hash":"1723620104119286566","title":"Redox Homeostasis & Detoxification","description":"This cluster is dominated by GO terms related to redox balance and detoxification, such as cell redox homeostasis, cellular oxidant detoxification, and cellular response to hydrogen peroxide, suggesting a collective function in managing oxidative stress. Some terms (e.g., I-kappaB phosphorylation, lipoprotein biosynthesis) may be peripheral or annotation noise, but the core signal points to redox maintenance and detox pathways. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0022417","count":1}]},{"hash":"679376963431221308","title":"Mitotic regulation and kinase signaling","description":"The top GO terms center on cell cycle control, including kinetochore localization and negative regulation of CDK activity, pointing to mitotic regulation. Additional terms relate to broader kinase signaling and growth-associated processes (KIT signaling, angiogenesis, axon regeneration), suggesting involvement in signaling pathways linked to division and development. With only three proteins, the theme is plausible but not definitive, so I assign Medium confidence.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0034501","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0048679","count":2},{"id":"GO:0002688","count":2},{"id":"GO:0042698","count":2}]},{"hash":"1087333888554966462","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around developmental processes and patterning\u2014left-right pattern formation, cartilage morphogenesis, various cell lineage differentiations (pancreatic B cells, trophoblast, EMT in heart development)\u2014with some supporting terms for gene expression regulation (splicing, transcription). The dominant theme is embryonic differentiation and tissue morphogenesis, despite some ancillary regulatory terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0060806","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0032298","count":1},{"id":"GO:0000398","count":1}]},{"hash":"387800176510775238","title":"Rho-regulated adhesion and migration","description":"The terms converge on cell adhesion and movement, with emphasis on Rho-mediated signaling, fibroblast migration, substrate-dependent spreading, and tight junction assembly. This suggests a cohesive theme of regulating cytoskeletal dynamics and cell\u2013cell/ECM contacts, guided by Rho and related cascades (JNK/p38). Some terms like placenta development or platelet activation may reflect broader adhesion/signaling contexts rather than a single process, but the core signal points to Rho-dependent adhesion and migration. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0071226","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0001893","count":2}]},{"hash":"1024470860559819611","title":"Vacuolar trafficking and ion homeostasis","description":"This cluster centers on vacuole-related processes: vacuole organization, targeting to vacuole, and vacuolar acidification, complemented by ion transport and homeostasis (protons, sodium, copper) and proton-motive force-driven ATP synthesis. Together these terms suggest proteins involved in vacuolar biogenesis/trafficking and membrane ion transport, with energetic processes supporting vacuolar function. Some terms are obsolete, but the core theme remains vacuolar function and ion management.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007033","count":2},{"id":"GO:0006623","count":2},{"id":"GO:0007035","count":2},{"id":"GO:0006878","count":2},{"id":"GO:0015991","count":2}]},{"hash":"336177976782679734","title":"Mitochondrial respiration and protein import","description":"The cluster is dominated by mitochondrial energy metabolism terms: respirasome assembly, electron transport, aerobic respiration, and proton translocation, along with protein import into the mitochondrial matrix and regulation of membrane permeability. These collectively point to mitochondrial respiration and protein import as the core theme, with one unrelated term present that does not change the overall focus.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097250","count":2},{"id":"GO:2000134","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0070940","count":1},{"id":"GO:0010867","count":1}]},{"hash":"2143076798361481546","title":"Cofactor biosynthesis and Fe-S dependent metabolism","description":"The terms converge on the biosynthesis and maturation of essential cofactors (lipoylation, Fe-S cluster assembly) and redox cofactors (menaquinone, phylloquinone), which support glycine cleavage and energy-yielding pathways like beta-oxidation and amino acid catabolism, indicating a focus on cofactor-dependent metabolism.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019464","count":1},{"id":"GO:0009249","count":1},{"id":"GO:0017000","count":1},{"id":"GO:0009234","count":1},{"id":"GO:0010124","count":1}]},{"hash":"708410143197905675","title":"Nucleotide biosynthesis and salvage","description":"They are annotated with multiple nucleotide metabolism terms (purine ribonucleotide interconversion, AMP salvage, ADP/CDP biosynthesis, and nucleotide phosphorylation), indicating a cohesive function in nucleotide biosynthesis and salvage; the brain/liver development terms likely reflect broader expression rather than core function, while the cadmium response is an outlier.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046041","count":3},{"id":"GO:0015951","count":3},{"id":"GO:0046705","count":3},{"id":"GO:0046940","count":3},{"id":"GO:0046939","count":3}]},{"hash":"1389326783657923093","title":"Mitochondrial translation and tRNA charging","description":"GO terms cluster around translation and multiple mitochondrial tRNA aminoacylation processes (seryl, threonyl, prolyl, glycyl), plus selenocysteine biosynthesis, indicating a module of mitochondrial protein synthesis machinery and tRNA charging. The terms suggest the proteins contribute to mitochondrial translation and aminoacyl-tRNA synthetase activities, with a minor outlier term likely noise. Overall, the cluster appears representative of mitochondrial translation/charging functions.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097056","count":1},{"id":"GO:0006450","count":1},{"id":"GO:0070158","count":1},{"id":"GO:0016260","count":1},{"id":"GO:0070159","count":1}]},{"hash":"1998704343830895820","title":"Ribosome Biogenesis and Translation","description":"The top GO terms center on translation, ribosomal subunit assembly, and maturation of SSU-rRNA, with additional links to translational termination and the stringent response, all pointing to the core protein synthesis machinery and ribosome biogenesis in cells.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006415","count":1},{"id":"GO:0015968","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0000028","count":1}]},{"hash":"2054910319260561419","title":"Biosynthesis and metabolism cluster","description":"This cluster is skewed toward biosynthetic processes, with terms like antibiotic biosynthesis, biotin and cobalamin biosynthesis, and sterol biosynthesis, plus related metabolic and cellular growth terms. While some terms (e.g., transcription regulation by RNA Pol II and nodulation) appear less central, the strongest signals point to biosynthesis and metabolic functions as the core theme, giving a moderate level of confidence that this label captures the cluster\u2019s essence.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0035690","count":1},{"id":"GO:0000056","count":1},{"id":"GO:0009877","count":1}]},{"hash":"2270017997021455871","title":"Mitochondrial apoptosis and oxidative stress","description":"These proteins share GO terms related to mitochondrial electron transport and cytochrome c\u2013mediated apoptosis, hydrogen peroxide metabolism, and apoptotic process, pointing to a coherent function in mitochondrial regulation of apoptosis and oxidative stress. Despite a few outlier terms like photosynthesis, the dominant theme is mitochondrial function and cell death signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0008635","count":3},{"id":"GO:0006470","count":3},{"id":"GO:0010730","count":3},{"id":"GO:0006122","count":3},{"id":"GO:0018063","count":3}]},{"hash":"1376470668290239570","title":"Nuclear transcription and chromatin regulation in development","description":"The proteins appear linked to nuclear control of gene expression (negative regulation of transcription by RNA polymerase II, chromatin-related regulation, nucleus organization, chromosome condensation) with accompanying developmental morphology terms (cardiac atrium and pericardium morphogenesis, oogenesis) and regulatory signaling, suggesting a cohesive theme of transcription/chromatin regulation during development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0035023","count":1},{"id":"GO:0003209","count":1},{"id":"GO:0033128","count":1},{"id":"GO:0006997","count":1}]},{"hash":"2292218105962123477","title":"Transmembrane transporter proteins","description":"The top GO terms overwhelmingly point to transmembrane transport across membranes for diverse substrates (vitamins, xenobiotics, sugars, and related compounds) and vesicular transport, suggesting these proteins function primarily as membrane transporters or transporter-associated proteins.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0006855","count":3},{"id":"GO:1900754","count":2},{"id":"GO:0098700","count":2},{"id":"GO:1904728","count":2}]},{"hash":"490455192722959653","title":"GPCR Signaling and Visual Perception","description":"This cluster is dominated by GO terms for G protein-coupled receptor signaling and visual perception, including GPCR signaling pathways and the G protein-coupled opsin signaling pathway, suggesting the proteins function in GPCR-mediated signal transduction tied to light sensing. There are additional mitochondrial transcription and RNA methylation terms present, which are less clearly connected to GPCR signaling and may reflect annotation noise or multifunctionality, but the core theme appears to be GPCR signaling related to vision.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":1},{"id":"GO:0016056","count":1},{"id":"GO:0045745","count":1},{"id":"GO:0045742","count":1},{"id":"GO:0007601","count":1}]},{"hash":"1671861842109123184","title":"Ribosome Biogenesis and mRNA Surveillance","description":"These proteins are annotated with translation-related processes (initiation, termination, overall translation) and maturation of rRNA (SSU/LSU/5.8S), along with RNA surveillance pathways (No-Go Decay, Non-Stop Decay). This combination points to a cohesive theme of ribosome assembly and quality control during translation, including rRNA processing and mRNA decay checks. The larval lymph gland hemopoiesis term is incidental to the core function here.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0035167","count":1},{"id":"GO:0071025","count":1},{"id":"GO:0070966","count":1},{"id":"GO:0000463","count":1}]},{"hash":"948668045880677871","title":"Embryonic development signaling and differentiation regulation","description":"The GO terms converge on embryonic development and regulation of cell fate and differentiation (e.g., TGF-beta signaling, optic fissure closure, somitogenesis, stem cell maintenance, and differentiation modulation), with additional vascular and extracellular matrix-related responses, suggesting a broad developmental regulation theme.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045578","count":2},{"id":"GO:0035767","count":2},{"id":"GO:0042662","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0071504","count":2}]},{"hash":"2043643871411836007","title":"Developmental Regulation and Morphogenesis","description":"The GO terms cover diverse developmental and morphogenetic roles across tissues (eye, somite, cerebellar neurons, ciliary body, vasculature) and include signaling regulation (Notch) and modulation of cell proliferation and migration, suggesting a general theme of developmental regulation and tissue morphogenesis rather than a single tissue-specific function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016330","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0021940","count":1},{"id":"GO:0001757","count":1},{"id":"GO:0045747","count":1}]},{"hash":"60033127174436389","title":"Intracellular Ion Homeostasis","description":"The GO terms show a strong emphasis on ions (Na+, K+, Ca2+, Mn2+) and their cellular handling, including homeostasis and transport between compartments (cytosol, ER). While a couple terms are less obviously linked (e.g., nerve formation, steroid response), the dominant signal is intracellular ion balance and ion transport, justifying this label.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071383","count":3},{"id":"GO:0021650","count":3},{"id":"GO:0002028","count":3},{"id":"GO:1901205","count":3},{"id":"GO:0006874","count":3}]},{"hash":"1411344380056426863","title":"Embryonic development and organogenesis","description":"The GO terms cluster around developmental processes across multiple tissues and organs (reproductive ducts, brain regions, somites, heart, pancreas, nervous system). This points to a broad theme of embryonic development and tissue patterning rather than a single specific pathway or function, making an organogenesis-focused label appropriate.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061205","count":3},{"id":"GO:0021570","count":3},{"id":"GO:0060163","count":3},{"id":"GO:2000288","count":3},{"id":"GO:0021723","count":3}]},{"hash":"3902011665872136","title":"Bacterial cell wall biosynthesis and antibiotic pathways","description":"The top GO terms include peptidoglycan biosynthetic process, lipoteichoic acid biosynthetic process, and antibiotic biosynthetic/metabolic processes, which together point to production of cell wall components and antibiotics in bacteria (likely Gram-positive). Some terms seem unrelated (e.g., xenobiotic glucuronidation, plant secondary metabolite biosynthesis, neuronal paranode localization), likely annotation noise, but the dominant signals reflect cell wall assembly and antibiotic-related metabolism.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0016999","count":3},{"id":"GO:0009252","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0052697","count":3},{"id":"GO:0051301","count":3}]},{"hash":"1211213546179586316","title":"Osteogenesis and cartilage formation signaling","description":"GO terms emphasize skeletal development, notably cartilage condensation and osteoblast differentiation, with regulatory links to IGF signaling and MAPK pathways, indicating a role in bone formation. While there are a few ancillary terms, the core signal converges on bone/cartilage development processes.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0045669","count":2},{"id":"GO:0043568","count":2},{"id":"GO:0043410","count":2},{"id":"GO:0090238","count":1}]},{"hash":"199612424109022536","title":"Mitotic progression and chromosome condensation","description":"The term set centers on mitotic control: G1/S and G2/M transitions, spindle pole separation, and histone H3-S10 phosphorylation for chromosome condensation, with DNA-templated transcription associated with cell division. This combination indicates a cohesive cluster of proteins involved in mitosis and cell cycle regulation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":3},{"id":"GO:2000775","count":3},{"id":"GO:0033598","count":3},{"id":"GO:0046626","count":3},{"id":"GO:0006351","count":3}]},{"hash":"58902145813105851","title":"Morphogenesis and calcium signaling","description":"The top GO terms cluster around developmental morphogenesis (adenohypophysis morphogenesis, branching morphogenesis of blood vessels, lymphangiogenesis) and calcium-dependent signaling (regulation of calcineurin-NFAT, postsynaptic cytosolic calcium concentration). While a couple of terms relate to DNA repair or kinetochore localization, the strongest shared theme is morphogenesis with calcium signaling, suggesting the proteins may participate in developmental patterning with calcium-dependent regulatory pathways.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":3},{"id":"GO:0070940","count":3},{"id":"GO:0042994","count":3},{"id":"GO:0034501","count":3},{"id":"GO:0070301","count":3}]},{"hash":"1718023236418522962","title":"Unknown","description":"The GO terms cover a wide range of processes (DNA replication, chromatin assembly, ER protein folding, mitochondrial complex assembly, glycosylation, etc.) with no clear, single functional theme dominating the cluster, making a cohesive label unlikely. Among the terms, several are related to protein processing/assembly but others pertain to genome maintenance, giving an overall heterogeneous set.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070651","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0090296","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0070389","count":1}]},{"hash":"659019667174198965","title":"Cell Cycle Regulation and Transcription","description":"The top GO terms center on DNA-templated transcription and cell-cycle control (G1/S transition, CDK activity, and general regulation of the cell cycle). A couple terms reference gland development, which may reflect tissue-specific expression, but the dominant signal ties transcriptional regulation to cell-cycle progression, with stress signaling (ER UPR, leptin response, X-ray) that can accompany proliferative states.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033327","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0060749","count":3},{"id":"GO:0030968","count":2},{"id":"GO:0000082","count":2}]},{"hash":"1296117695085898339","title":"Brain and Retina Development","description":"The top GO terms cluster around neural development: brain development, forebrain development, retina development, rhombomere development, subpallium neuron fate, and medullary reticular formation development, indicating a cohesive brain/neuronal development theme. A couple of terms (male gonad development, single fertilization) are outliers.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0007338","count":2}]},{"hash":"1380054095257044310","title":"Stress-Response and Protein Quality Control","description":"This cluster centers on cellular stress responses and proteome maintenance, with GO terms for sumoylation, heat acclimation, and autophagy (mitophagy and aggrephagy) plus aspects of protein trafficking to the nuclear pore. Additional transcription regulation and rRNA maturation terms suggest broader gene-expression and ribosome biogenesis involvement under stress. The combined signals point to a general role in stress-related quality control rather than a single specific enzymatic function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":3},{"id":"GO:0010286","count":2},{"id":"GO:0090204","count":2},{"id":"GO:0006357","count":2},{"id":"GO:0070911","count":2}]},{"hash":"548446014424550614","title":"Fatty acid transport and beta-oxidation","description":"The GO terms are dominated by lipid metabolism and transport: long-chain fatty acid transport, lysophospholipid transport, triglyceride catabolic process, and positive regulation of fatty acid beta-oxidation, suggesting these proteins participate in fatty acid uptake and oxidation. Some oxidative stress/detoxification and intestinal absorption terms appear, but the lipid-focused terms are most representative of the cluster\u2019s function. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0050892","count":2},{"id":"GO:0043154","count":2},{"id":"GO:0019433","count":2}]},{"hash":"2167346412378041958","title":"Developmental morphogenesis and cell polarity","description":"The top GO terms cluster around developmental patterning and tissue morphogenesis (convergent extension in axis elongation, axon extension, ommatidial planar polarity, skeletal joint morphogenesis, bone mineralization) and cytoskeletal organization (protein localization to microtubules). Together these suggest a role for these proteins in shaping tissues and establishing polarity during development, rather than a single metabolic or signaling pathway. Some terms are obsolete or broad, but the recurring theme is developmental morphogenesis with polarity cues.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060028","count":2},{"id":"GO:0048675","count":2},{"id":"GO:0035372","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0038031","count":1}]},{"hash":"1989291931543104529","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":3},{"id":"GO:0000398","count":3},{"id":"GO:1901254","count":3},{"id":"GO:0033129","count":3},{"id":"GO:0042759","count":3}]},{"hash":"1331914169921679294","title":"Ethylene and Gibberellin Biosynthesis during Fruit Ripening","description":"GO terms cluster around plant hormone biosynthesis (ethylene, gibberellin), fruit ripening, and related metabolism (proanthocyanidin biosynthesis; salicylic acid turnover), suggesting a plant development/fruit maturation program. A couple of terms (translation, penicillin biosynthetic process) appear as noise and do not define the core function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0045727","count":1},{"id":"GO:0042318","count":1},{"id":"GO:0009835","count":1},{"id":"GO:0055114","count":1}]},{"hash":"1770950080654818653","title":"Telomere maintenance and DNA repair","description":"Top terms point to telomere biology and DNA repair (meiotic telomere clustering, telomere maintenance via recombination, and error-free translesion synthesis) and chromatin regulation (neddylation, ubiquitination). A few GO terms about neuron development appear, but the dominant theme is nuclear genome stability, supporting the label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0045141","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0010976","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0045116","count":3}]},{"hash":"1523462015510325925","title":"Nucleotide Excision Repair and Ubiquitination","description":"The GO terms are dominated by nucleotide excision repair components (preincision complex assembly, DNA damage recognition, global genome NER) and by ubiquitination-related processes (protein ubiquitination, neddylation), suggesting a cluster of proteins involved in DNA damage sensing/repair coupled with ubiquitin-related post-translational modification. Occasional cell-cycle related terms appear but do not override the main theme, supporting a cohesive NER/ubiquitin module.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045116","count":2},{"id":"GO:1900095","count":1},{"id":"GO:0006294","count":1},{"id":"GO:1902104","count":1},{"id":"GO:0000717","count":1}]},{"hash":"167674196955356555","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:1903215","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0045676","count":1},{"id":"GO:0061158","count":1}]},{"hash":"846682282418879660","title":"Unknown","description":"The GO terms span diverse contexts (heart development, immune and stress responses, plant hormone signaling, meiosis, photoreceptor localization, and ciliogenesis) with no single coherent function or pathway linking them, and there are no edges to suggest a defined interaction network. Therefore a specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901207","count":2},{"id":"GO:0035457","count":2},{"id":"GO:0003179","count":2},{"id":"GO:0045141","count":2},{"id":"GO:0070301","count":2}]},{"hash":"400474843089467843","title":"Cardiac muscle development and calcium signaling","description":"The top GO terms cluster around heart development (trabecula formation, ventricular morphogenesis) and calcium handling (calcium release from the SR) with electrical coupling in cardiac conduction, suggesting a theme of cardiac development and excitation-contraction coupling. Some non-cardiac terms appear, but the cardiac-related signals are most representative of the set. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007183","count":2},{"id":"GO:0014808","count":2},{"id":"GO:0060347","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0086064","count":1}]},{"hash":"914024485126635979","title":"Vertebrate Development and Cell Fate Specification","description":"GO terms are dominated by vertebrate development and tissue-specific cell fate commitments (somite, rhombomere, ureteric bud, spleen, pancreas) with a general note on transcription regulation. This points to a cluster of proteins involved in broad developmental programs and lineage specification rather than a single enzymatic function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0048536","count":3},{"id":"GO:0000122","count":3},{"id":"GO:2000288","count":2},{"id":"GO:0021570","count":2}]},{"hash":"1944885503125151232","title":"Neuronal Signaling and Visual Perception","description":"This cluster shows brain-related processes: dopaminergic and GABAergic synaptic transmission, visual perception and learning, and pathways like ERK signaling and responses to morphine and prostaglandins. The common thread is neural signaling and sensory processing in the brain, including visual function and neurotransmitter modulation.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002035","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0010759","count":3}]},{"hash":"2277364971257327724","title":"Neural development and neuron migration","description":"The Top Terms are dominated by neural development processes: neurogenesis (GO:0022008), peripheral nervous system axon regeneration (GO:0014012), dendrite self-avoidance (GO:0070593), and chemorepulsion guiding interneuron migration in the olfactory bulb (GO:0021836). Compound eye photoreceptor differentiation (GO:0001751) also points to neural/eye development. While interferon-related terms appear, the prominent theme is nervous system development and neuronal wiring, suggesting this label. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032729","count":3},{"id":"GO:0001751","count":2},{"id":"GO:0070593","count":2},{"id":"GO:0035457","count":2},{"id":"GO:0021836","count":2}]},{"hash":"433582290100561603","title":"Cell Cycle and Growth Signaling","description":"This cluster shows frequent GO terms related to cell division and mitosis (mitotic spindle assembly, cell division) alongside growth and proliferation (multicellular organism growth, cell population proliferation) and regulatory processes (ERK signaling, ubiquitination, phosphorylation). Ribosome biogenesis also appears, suggesting coordinated protein synthesis during cell growth. Taken together, these terms point to a core theme of cell cycle progression and growth regulation, with supportive signaling and regulatory mechanisms. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000747","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0070374","count":2}]},{"hash":"1265154008908169279","title":"Neuronal signaling and MAPK pathway regulation","description":"The GO terms cluster around nervous system development and cellular signaling, including dopaminergic response, positive regulation of ERK1/2 and JNK cascades, and calcium-dependent exocytosis. The mix points to proteins involved in neuronal signal transduction and modulation of intracellular kinase pathways, rather than a single isolated function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0031647","count":3},{"id":"GO:0070374","count":3},{"id":"GO:1903351","count":3},{"id":"GO:0046330","count":3}]},{"hash":"2072964949905781219","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0061158","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0007014","count":3},{"id":"GO:0043045","count":3},{"id":"GO:1900246","count":3}]},{"hash":"1207753293213614141","title":"Unknown","description":"The GO terms connected to these proteins are highly diverse, spanning stem cell maintenance, transcription initiation, androgen receptor signaling, translational fidelity and elongation, actin regulation, radiation response, cellular fusion, Rho signaling, and chromatin-related processes. With zero edges and no shared high-frequency terms, there is no clear cohesive function tying the proteins together, suggesting a heterogeneous set rather than a single biological module.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019827","count":1},{"id":"GO:0006367","count":1},{"id":"GO:0030521","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0006414","count":1}]},{"hash":"616566073275934193","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000185","count":1},{"id":"GO:0046330","count":1},{"id":"GO:0031118","count":1},{"id":"GO:0000470","count":1},{"id":"GO:1900745","count":1}]},{"hash":"1637828301781121839","title":"Autonomic dopaminergic-adrenergic signaling","description":"The proteins cluster around dopaminergic synaptic transmission and MAPK-activating adrenergic receptor signaling, with epinephrine/norepinephrine\u2013driven heart rate regulation, pointing to autonomic nervous system modulation of cardiovascular/metabolic functions. Additional terms such as xenobiotic response, TNF production regulation, diet-induced thermogenesis, enteric smooth muscle differentiation, and prepulse inhibition suggest broader neuromodulatory and stress-responsive pathways linking autonomic signaling to gut, immune, and sensory processing. Overall, the common theme appears to be autonomic/neuromodulatory signaling rather than a single tissue-specific function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001963","count":1},{"id":"GO:0071883","count":1},{"id":"GO:0001996","count":1},{"id":"GO:0048609","count":1},{"id":"GO:0051967","count":1}]},{"hash":"993698363281917045","title":"Embryonic Morphogenesis and Vascular Development","description":"This cluster is dominated by terms related to embryonic development and tissue morphogenesis, especially neural crest cell migration and cardiovascular/vascular morphogenesis (mitral valve, nephric duct, venous vessel, and aorta). A smaller subset includes DNA repair and response to ionizing radiation, which are less central to the main signal. Overall, the label reflects a developmental morphogenesis and vascular development theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001755","count":2},{"id":"GO:0006281","count":1},{"id":"GO:0010212","count":1},{"id":"GO:0000187","count":1},{"id":"GO:0048672","count":1}]},{"hash":"1396510304617801000","title":"Neural development and synapse assembly","description":"The top GO terms cluster around nervous system development, synapse assembly, and cell adhesion (homophilic/heterophilic), with hints of neural remodeling (collateral sprouting) and autonomic functions (regulation of heart rate by cardiac conduction). This suggests the proteins participate in neural development and synaptic organization, with adhesion processes facilitating cell interactions in the developing nervous system.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0086091","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0050927","count":3},{"id":"GO:0048661","count":3}]},{"hash":"1020774902789498616","title":"Unknown","description":"The proteins are associated with a broad and divergent set of GO terms, including various metabolism processes (N-acetylglucosamine, arginine, putrescine, acetoin, melatonin, mycothiol biosynthesis) and chromatin-related functions (subtelomeric heterochromatin formation, histone H4 acetylation) as well as plant development (regulation of leaf formation). This lack of a cohesive, single biological theme suggests there is no clear common function linking the cluster, so a confident label cannot be assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006044","count":2},{"id":"GO:0010125","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0017196","count":2},{"id":"GO:0009447","count":2}]},{"hash":"296671465029342790","title":"Unknown","description":"The GO terms span diverse processes including N-acetylglucosamine and arginine biosynthesis, mycothiol biosynthesis, acetylation-related chromatin functions, and plant-specific processes like leaf formation and melatonin biosynthesis, with no clear single theme tying all three proteins together.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006044","count":3},{"id":"GO:0010125","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0017196","count":3},{"id":"GO:0009447","count":3}]},{"hash":"2143246527269295578","title":"Ubiquitin-Dependent Antiviral Defense","description":"The dominant terms point to ubiquitin-dependent protein catabolic process (and ERAD) together with innate immune and antiviral defense responses. This suggests the cluster centers on ubiquitin-mediated proteolysis that can regulate antiviral signaling and protein quality control. Some other terms (developmental and signaling) may reflect broader roles of these proteins, but the core theme is ubiquitin-driven degradation linked to innate immunity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0060384","count":1}]},{"hash":"1225575985037932977","title":"Actin Cytoskeleton Remodeling and Cell Adhesion","description":"Based on the GO terms, the cluster centers on actin dynamics and adhesion: regulation of Rac/Rho signaling, GTPase activity, and assembly of filopodia/podosomes, along with actin cytoskeleton organization and substrate adhesion-dependent spreading. While immune-context terms appear (IL-7 response, NK T cell differentiation), the dominant signal is cytoskeletal remodeling and adhesion processes driven by Rho family GTPases.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900026","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0098761","count":3},{"id":"GO:0035020","count":3},{"id":"GO:0001865","count":3}]},{"hash":"2094407590766840131","title":"Unknown","description":"The terms mix bacterial cell division (septum assembly, conjugation) with ribosome biogenesis/translation and some signaling/immune terms, producing no single cohesive function for the cluster; therefore a specific label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090529","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0045087","count":1},{"id":"GO:1901001","count":1}]},{"hash":"1767101241142992597","title":"Amino acid catabolism and detoxification","description":"The cluster shows multiple catabolic processes for amino acids (phenylalanine, tyrosine, and methylglyoxal via glutathione) and xenobiotic/metabolic detoxification, including glutathione metabolism; these together suggest a metabolic/detox role for the proteins. Some terms appear unrelated (e.g., transcription regulation, morphogenesis), likely noise given the small cluster, so the core signal supports catabolism and detoxification.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006559","count":2},{"id":"GO:0019243","count":2},{"id":"GO:0006572","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0042178","count":2}]}]