{"hash":"827443867359072014","title":"Glycolysis and TCA Cycle Core Metabolism","description":"The cluster is strongly enriched for glycolysis (GO:0006096), the tricarboxylic acid cycle (GO:0006099), and acetyl-CoA\u2013related steps such as pyruvate decarboxylation to acetyl-CoA (GO:0006086) and gluconeogenesis (GO:0006094). It also includes 2-oxoglutarate and malonyl-CoA\u2013related processes, and even amino-acid catabolism to acetyl-CoA (lysine and leucine). Together these terms point to a cohesive central carbon metabolism module focused on energy production and acetyl-CoA flux; sodium ion transport appears incidental rather than defining the cluster.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":null,"members":[{"accession":"NP_956241.2","go_terms":["GO:0080093","GO:0048569","GO:0007584","GO:0006734","GO:0006099","GO:0051591","GO:0043627","GO:0006097","GO:0006096","GO:0001666","GO:0042542","GO:0042493","GO:0006107","GO:0009749","GO:0043065","GO:0055114","GO:0019244","GO:0006108"]},{"accession":"NP_956854.2","go_terms":["GO:0043617","GO:0006086","GO:0033512","GO:0006213","GO:0006099","GO:0006096","GO:0000002","GO:0006103","GO:0006814","GO:2001295","GO:0042759","GO:0006552","GO:0006094"]},{"accession":"NP_957245.2","go_terms":["GO:0008585","GO:0006099","GO:0006097","GO:0019878","GO:1903976","GO:0006749","GO:0071071","GO:0006740","GO:0009098","GO:1904465","GO:0060253","GO:0006979","GO:0006537","GO:0006741","GO:0006103","GO:0006102","GO:0060696","GO:0048545"]},{"accession":"NP_958895.1","go_terms":["GO:0043617","GO:0006086","GO:0000002","GO:0006099","GO:0006103","GO:0033512","GO:0006096","GO:0006814","GO:2001295","GO:0042759","GO:0006552","GO:0006213","GO:0006094"]},{"accession":"NP_997832.2","go_terms":["GO:0043617","GO:0006086","GO:0033512","GO:0006213","GO:0006099","GO:0006096","GO:0000002","GO:0006103","GO:0006814","GO:2001295","GO:0042759","GO:0006552","GO:0006094"]},{"accession":"XP_073771601.1","go_terms":["GO:0006085","GO:0006099","GO:0006104"]},{"accession":"XP_073771330.1","go_terms":["GO:0021756","GO:0006099","GO:0021860","GO:0061034","GO:0021695","GO:0022028","GO:0006096","GO:0055114","GO:0021794","GO:0072756","GO:0009228","GO:0072747","GO:0046166","GO:0052865","GO:0061732","GO:0006098","GO:0005999","GO:0010510","GO:0006006","GO:0016114","GO:0046487","GO:0009083"]},{"accession":"XP_073763144.1","go_terms":["GO:0019878","GO:0006090","GO:0006637","GO:0009098","GO:0043640","GO:0070542","GO:0006552","GO:0006814","GO:0001889","GO:0042594","GO:0019336","GO:0046951","GO:0007584","GO:0007005","GO:0006094","GO:0033512","GO:0006099","GO:2001295","GO:0042759","GO:0006096","GO:0006086","GO:0006213","GO:0044791","GO:0019074"]},{"accession":"NP_998163.1","go_terms":["GO:0033539","GO:0009437"]},{"accession":"XP_073769897.1","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109"]},{"accession":"XP_073765383.1","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109"]}],"graph":[["NP_956854.2","NP_956241.2",0.708],["NP_956854.2","NP_998163.1",0.538],["NP_956854.2","NP_957245.2",0.804],["NP_956854.2","NP_958895.1",0.735],["NP_956854.2","NP_997832.2",0.773],["NP_956854.2","XP_073771330.1",0.773],["NP_956854.2","XP_073771601.1",0.863],["NP_956854.2","XP_073769897.1",0.77],["NP_956854.2","XP_073763144.1",0.648],["NP_956854.2","XP_073765383.1",0.792],["NP_956241.2","NP_957245.2",0.776],["NP_956241.2","NP_958895.1",0.71],["NP_956241.2","NP_997832.2",0.77],["NP_956241.2","NP_998163.1",0.668],["NP_956241.2","XP_073763144.1",0.81],["NP_956241.2","XP_073765383.1",0.694],["NP_956241.2","XP_073769897.1",0.663],["NP_956241.2","XP_073771330.1",0.765],["NP_956241.2","XP_073771601.1",0.799],["XP_073763144.1","NP_957245.2",0.809],["XP_073763144.1","NP_958895.1",0.733],["XP_073763144.1","NP_997832.2",0.661],["XP_073763144.1","NP_998163.1",0.612],["XP_073763144.1","XP_073765383.1",0.792],["XP_073763144.1","XP_073769897.1",0.786],["XP_073763144.1","XP_073771330.1",0.769],["XP_073763144.1","XP_073771601.1",0.748],["NP_998163.1","NP_957245.2",0.617],["NP_998163.1","NP_958895.1",0.678],["NP_998163.1","NP_997832.2",0.555],["NP_998163.1","XP_073771330.1",0.73],["NP_998163.1","XP_073771601.1",0.806],["NP_998163.1","XP_073769897.1",0.743],["NP_998163.1","XP_073765383.1",0.761],["XP_073771330.1","NP_957245.2",0.786],["XP_073771330.1","NP_958895.1",0.776],["XP_073771330.1","NP_997832.2",0.803],["XP_073771330.1","XP_073765383.1",0.707],["XP_073771330.1","XP_073769897.1",0.703],["XP_073771330.1","XP_073771601.1",0.754],["NP_958895.1","NP_957245.2",0.814],["NP_958895.1","NP_997832.2",0.747],["NP_958895.1","XP_073765383.1",0.824],["NP_958895.1","XP_073769897.1",0.796],["NP_958895.1","XP_073771601.1",0.786],["XP_073771601.1","NP_957245.2",0.797],["XP_073771601.1","NP_997832.2",0.852],["XP_073771601.1","XP_073765383.1",0.788],["XP_073771601.1","XP_073769897.1",0.838],["XP_073765383.1","NP_957245.2",0.771],["XP_073765383.1","NP_997832.2",0.817],["NP_957245.2","NP_997832.2",0.823],["NP_957245.2","XP_073769897.1",0.768],["NP_997832.2","XP_073769897.1",0.808]],"all_go_terms":{"GO:0080093":1,"GO:0006096":6,"GO:0007584":2,"GO:0043627":1,"GO:0006097":2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