{"hash":"222406839928616030","title":"Mitochondrial-Vacuolar Ion Transport and Energy Metabolism","description":"These proteins emphasize ion transport across membranes (sodium, proton transmembrane transport), vacuolar processes (vacuole organization and acidification), and mitochondrial-related energy activities (proton motive force-driven ATP synthesis, regulation of cellular respiration). They also include organelle targeting (protein targeting to vacuole/mitochondrion) and mitochondrial autophagy, plus copper ion homeostasis. Together, this points to a coordinated theme of organelle ion homeostasis and energy management involving mitochondria and vacuoles, with protein trafficking underpinning these functions.","confidence":"High","size":17,"edges":126,"triangles":553,"max_degree":16,"top_function":null,"members":[{"accession":"XP_068074486.1","go_terms":["GO:0036444","GO:0051560"]},{"accession":"XP_068077403.1","go_terms":["GO:0097428","GO:0016226"]},{"accession":"XP_005157201.1","go_terms":["GO:0010259","GO:0000422","GO:0043457"]},{"accession":"NP_956899.1","go_terms":["GO:0010259","GO:0000422","GO:0043457"]},{"accession":"NP_956800.1","go_terms":["GO:0033617","GO:1902600","GO:0042774"]},{"accession":"NP_957142.1","go_terms":[]},{"accession":"NP_991117.1","go_terms":["GO:0007033","GO:0006878","GO:0015991","GO:0006626","GO:0007035","GO:0006623","GO:0042777","GO:0006814"]},{"accession":"NP_957500.2","go_terms":["GO:0006784"]},{"accession":"NP_957008.1","go_terms":["GO:0035458","GO:0071300","GO:0045732","GO:0097191","GO:0072593","GO:0045039","GO:0043280","GO:2001243"]},{"accession":"NP_957085.1","go_terms":[]},{"accession":"NP_998193.1","go_terms":["GO:0007033","GO:0006878","GO:0015991","GO:0006626","GO:0007035","GO:0006623","GO:0042777","GO:0006814"]},{"accession":"NP_956268.1","go_terms":[]},{"accession":"NP_956289.1","go_terms":["GO:1902600","GO:0006123"]},{"accession":"NP_956394.1","go_terms":["GO:0033617","GO:0097250","GO:0090201"]},{"accession":"NP_957098.2","go_terms":[]},{"accession":"NP_957470.1","go_terms":["GO:0007033","GO:0006878","GO:0015991","GO:0006626","GO:0007035","GO:0006623","GO:0042777","GO:0006814"]},{"accession":"NP_998190.1","go_terms":[]}],"graph":[["NP_957085.1","NP_956394.1",0.591],["NP_957085.1","XP_005157201.1",0.703],["NP_957085.1","NP_998190.1",0.643],["NP_957085.1","NP_998193.1",0.579],["NP_957085.1","NP_956800.1",0.654],["NP_957085.1","NP_956899.1",0.792],["NP_957085.1","NP_957008.1",0.704],["NP_957085.1","NP_957098.2",0.792],["NP_957085.1","NP_957142.1",0.608],["NP_957085.1","NP_957470.1",0.608],["NP_957085.1","NP_957500.2",0.751],["NP_957085.1","NP_991117.1",0.612],["NP_957085.1","XP_068077403.1",0.563],["NP_956268.1","NP_956394.1",0.576],["NP_956268.1","NP_956800.1",0.634],["NP_956268.1","NP_956899.1",0.704],["NP_956268.1","NP_957008.1",0.646],["NP_956268.1","NP_957098.2",0.766],["NP_956268.1","NP_957142.1",0.622],["NP_956268.1","NP_957470.1",0.51],["NP_956268.1","NP_957500.2",0.68],["NP_956268.1","NP_991117.1",0.663],["NP_956268.1","NP_998190.1",0.619],["NP_956268.1","NP_998193.1",0.559],["NP_956268.1","XP_005157201.1",0.665],["NP_956268.1","XP_068077403.1",0.528],["NP_956394.1","NP_956800.1",0.588],["NP_956394.1","NP_956899.1",0.626],["NP_956394.1","NP_957008.1",0.699],["NP_956394.1","NP_957098.2",0.72],["NP_956394.1","NP_957142.1",0.664],["NP_956394.1","NP_957470.1",0.603],["NP_956394.1","NP_957500.2",0.671],["NP_956394.1","NP_991117.1",0.632],["NP_956394.1","NP_998190.1",0.657],["NP_956394.1","NP_998193.1",0.569],["NP_956394.1","XP_005157201.1",0.74],["NP_956394.1","XP_068077403.1",0.608],["NP_991117.1","NP_956289.1",0.683],["NP_991117.1","NP_956800.1",0.594],["NP_991117.1","NP_956899.1",0.654],["NP_991117.1","NP_957008.1",0.659],["NP_991117.1","NP_957098.2",0.553],["NP_991117.1","NP_957142.1",0.719],["NP_991117.1","NP_957470.1",0.622],["NP_991117.1","NP_957500.2",0.566],["NP_991117.1","NP_998190.1",0.692],["NP_991117.1","NP_998193.1",0.678],["NP_991117.1","XP_005157201.1",0.788],["NP_991117.1","XP_068074486.1",0.623],["NP_991117.1","XP_068077403.1",0.515],["NP_956899.1","NP_956289.1",0.643],["NP_956899.1","XP_005157201.1",0.712],["NP_956899.1","NP_998190.1",0.684],["NP_956899.1","NP_998193.1",0.593],["NP_956899.1","NP_956800.1",0.605],["NP_956899.1","NP_957008.1",0.627],["NP_956899.1","NP_957098.2",0.751],["NP_956899.1","NP_957142.1",0.675],["NP_956899.1","NP_957470.1",0.657],["NP_956899.1","NP_957500.2",0.661],["NP_956899.1","XP_068077403.1",0.722],["NP_956899.1","XP_068074486.1",0.596],["NP_957008.1","NP_956289.1",0.682],["NP_957008.1","XP_005157201.1",0.76],["NP_957008.1","NP_998190.1",0.702],["NP_957008.1","NP_998193.1",0.698],["NP_957008.1","NP_956800.1",0.723],["NP_957008.1","NP_957098.2",0.778],["NP_957008.1","NP_957142.1",0.763],["NP_957008.1","NP_957470.1",0.744],["NP_957008.1","NP_957500.2",0.811],["NP_957008.1","XP_068077403.1",0.65],["NP_957008.1","XP_068074486.1",0.66],["NP_957098.2","NP_956289.1",0.667],["NP_957098.2","XP_005157201.1",0.746],["NP_957098.2","NP_998190.1",0.719],["NP_957098.2","NP_998193.1",0.792],["NP_957098.2","NP_956800.1",0.709],["NP_957098.2","NP_957142.1",0.762],["NP_957098.2","NP_957470.1",0.821],["NP_957098.2","NP_957500.2",0.53],["NP_957098.2","XP_068077403.1",0.744],["NP_957098.2","XP_068074486.1",0.784],["NP_956800.1","NP_956289.1",0.569],["NP_956800.1","XP_005157201.1",0.684],["NP_956800.1","NP_998190.1",0.708],["NP_956800.1","NP_998193.1",0.703],["NP_956800.1","NP_957142.1",0.702],["NP_956800.1","NP_957470.1",0.639],["NP_956800.1","NP_957500.2",0.778],["NP_956800.1","XP_068077403.1",0.624],["NP_956800.1","XP_068074486.1",0.62],["NP_957470.1","NP_957142.1",0.698],["NP_957470.1","NP_957500.2",0.774],["NP_957470.1","NP_998190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