{"hash":"2149343711735635292","title":"Ubiquitin-regulated innate and adaptive immunity","description":"These proteins cluster around immune signaling and regulation, highlighted by innate immune response, B cell homeostasis, and lymph node development. Ubiquitination terms (protein autoubiquitination, actin ubiquitination) point to post-translational control of signaling cascades, including regulation of the JNK pathway and negative regulation of RIG-I signaling, which modulates antiviral responses. The presence of vitamin D response and histone methylation-related terms suggests links to transcriptional and epigenetic regulation of immune genes. Together, the GO terms imply a module focused on ubiquitin-dependent tuning of immune signaling and lymphoid homeostasis rather than a single enzymatic 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