{"hash":"1601939281891081380","title":"Notch signaling and membrane proteolysis","description":"The top terms cluster around Notch pathway components, including Notch receptor processing and ectodomain proteolysis, plus amyloid-beta formation, which together suggest gamma-secretase\u2013mediated proteolysis of membrane proteins (Notch and APP). The pharynx development term aligns with Notch\u2019s developmental role. Peripheral terms like insulin secretion and mitochondrial processes are less connected, but don\u2019t outweigh the Notch/proteolysis theme.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"members":[{"accession":"NP_991139.1","go_terms":["GO:0007219","GO:0034205","GO:0006509","GO:0007220","GO:0031293","GO:0060465"]},{"accession":"NP_997757.1","go_terms":["GO:0035774","GO:1902361","GO:0061732"]},{"accession":"NP_998124.1","go_terms":["GO:2000378","GO:0031101","GO:0007612","GO:0030150","GO:0006820","GO:0007270","GO:0036444","GO:1903959","GO:0001662","GO:0030855","GO:1902017","GO:1903146"]},{"accession":"NP_998670.1","go_terms":["GO:0032469","GO:0034975"]},{"accession":"XP_001344822.3","go_terms":[]}],"graph":[["NP_991139.1","NP_997757.1",0.551],["NP_991139.1","NP_998124.1",0.572],["NP_991139.1","NP_998670.1",0.704],["NP_991139.1","XP_001344822.3",0.679],["NP_998124.1","NP_997757.1",0.615],["NP_998124.1","XP_001344822.3",0.6],["NP_998124.1","NP_998670.1",0.616],["NP_998670.1","NP_997757.1",0.6],["NP_998670.1","XP_001344822.3",0.652],["NP_997757.1","XP_001344822.3",0.544]],"all_go_terms":{"GO:0007219":1,"GO:0031293":1,"GO:0007220":1,"GO:0034205":1,"GO:0060465":1,"GO:0006509":1,"GO:0035774":1,"GO:1902361":1,"GO:0061732":1,"GO:2000378":1,"GO:0001662":1,"GO:1903146":1,"GO:0030855":1,"GO:0006820":1,"GO:0030150":1,"GO:0007612":1,"GO:1903959":1,"GO:0031101":1,"GO:0036444":1,"GO:0007270":1,"GO:1902017":1,"GO:0034975":1,"GO:0032469":1},"recipe_readded":[]}