[{"hash":"1146319777368892717","title":"Mitochondrial energy metabolism and gene expression","description":"This cluster is strongly enriched for mitochondrial respiration and ATP production terms (mitochondrial electron transport NADH to ubiquinone, mitochondrial ATP synthesis coupled electron transport, ubiquinone biosynthetic process), suggesting a core function in energy production. The presence of translation and DNA-templated transcription terms aligns with mitochondrial gene expression (mitochondrial translation/transcription). Some terms like photosynthesis and certain development-related terms may reflect cross-species annotations or broader metabolic links, but the dominant signal points to mitochondrial energy metabolism and related gene expression. ","confidence":"High","size":29,"edges":44,"triangles":5,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006120","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0019684","count":2},{"id":"GO:0006744","count":2}]},{"hash":"1145382360956458481","title":"Neural signaling and development","description":"The top GO terms show clear neural activity signals, notably neurotransmitter secretion and associative learning, suggesting a neuronal signaling theme. Additional GO terms indicate signaling regulation (dephosphorylation and phospholipid dephosphorylation) and cell\u2013matrix interactions (calcium-independent adhesion), which can accompany neural tissue function. Although there are some developmental and immune-related terms, the prominent neural signaling terms provide a coherent, high-level theme for this cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0048333","count":4},{"id":"GO:0016311","count":4},{"id":"GO:0046272","count":4},{"id":"GO:0097755","count":4}]},{"hash":"1318979915562768780","title":"Brain development and auditory function","description":"The top terms include substantia nigra development and sensory perception of sound, plus establishment of the endothelial barrier, suggesting a neural development/brain function theme with sensory and barrier components. Ion transport and mRNA processing terms further reflect neuronal cellular machinery supporting these brain-related roles, making the brain/auditory-focus label appropriate overall.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0048255","count":2},{"id":"GO:0006397","count":2}]},{"hash":"912608083954243213","title":"Plant cell wall biosynthesis and glycosylation","description":"The cluster is dominated by plant-specific processes: secondary cell wall biogenesis, glucuronoxylan biosynthesis, and cell wall organization, plus protein glycosylation terms, suggesting a cohesive set of proteins involved in building and modifying the plant cell wall and its glycoproteins. Some terms like brain segmentation or auditory perception appear unrelated and may reflect annotation noise, but the core signals point to plant cell wall formation and glycosylation.","confidence":"Medium","size":29,"edges":20,"triangles":1,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009834","count":5},{"id":"GO:0010417","count":5},{"id":"GO:0071555","count":5},{"id":"GO:0006486","count":5},{"id":"GO:0075015","count":5}]},{"hash":"807367171937357477","title":"Hepatic lipid and glycogen metabolism","description":"The top GO terms cluster around fatty acid catabolism (carnitine metabolism, long/medium-chain fatty acids), glycogen biosynthesis, and starvation response, all components of liver-centered energy metabolism. While edges are absent, the shared emphasis on lipid and carbohydrate metabolism in a liver context supports a cohesive label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019254","count":3},{"id":"GO:0045329","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0042758","count":3},{"id":"GO:0005978","count":3}]},{"hash":"718160382719425732","title":"Translation machinery and ribosome biogenesis","description":"The cluster's terms are dominated by translation and ribosome-related processes\u2014translation itself, ribosome biogenesis, translational elongation regulation, and cytoplasmic translation, plus selenocysteine incorporation and mRNA decay\u2014pointing to a core role in protein synthesis and ribosome assembly, with viral regulation and antibiotic response as peripheral notes.","confidence":"High","size":29,"edges":91,"triangles":364,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0042254","count":5},{"id":"GO:0046726","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0000747","count":4}]},{"hash":"2276138958466073079","title":"GPCR-cAMP signaling in cardiovascular system","description":"The cluster shows strong enrichment for GPCR signaling pathways that activate adenylate cyclase and phospholipase C (e.g., dopamine and adrenergic receptors), coupled to cAMP and other second-messenger processes, along with heart development and blood pressure regulation terms. This suggests a cohesive set of proteins involved in GPCR-mediated signaling impacting cardiovascular function. Some terms like phototransduction reflect broader GPCR roles in other tissues but do not override the central theme.","confidence":"Medium","size":29,"edges":282,"triangles":1274,"max_degree":27,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":29},{"id":"GO:0060158","count":29},{"id":"GO:0007603","count":29},{"id":"GO:0010513","count":29},{"id":"GO:0071880","count":29}]},{"hash":"975313155698433905","title":"Mitochondrial energy metabolism and insulin signaling","description":"The cluster is dominated by mitochondrial-focused terms (membrane fission, ATP transport, membrane potential regulation) alongside energy-related responses (adaptive thermogenesis, fatty acid response) and signals related to insulin/glucose, plus a oxidative stress response. This combination points to a cohesive theme of mitochondrial energy metabolism tightly linked to insulin signaling.","confidence":"High","size":29,"edges":7,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0061179","count":29},{"id":"GO:0090149","count":29},{"id":"GO:0032869","count":29},{"id":"GO:0000303","count":29},{"id":"GO:1990845","count":29}]},{"hash":"1376746149600436602","title":"Heart and Sensory Organ Development","description":"The top GO terms point to organogenesis in both the heart and sensory tissues (heart development; retina/cochlea morphogenesis; visual perception), suggesting proteins in this cluster collectively contribute to development and morphogenesis of cardiac and sensory organs. Additional terms related to immune and xenobiotic responses may reflect broader functional connections or pleiotropy, but the dominant signal is development of heart and sensory organs.","confidence":"Medium","size":29,"edges":17,"triangles":0,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0042742","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0090103","count":4}]},{"hash":"1784821968525881029","title":"Ribosome biogenesis and translation initiation","description":"This cluster is dominated by GO terms for rRNA maturation (both SSU and LSU, including 5.8S) and ribosome biogenesis, plus formation of translation preinitiation complexes and translation reinitiation, pointing to a core function in ribosome assembly and initiation of protein synthesis. Some RNA-processing terms appear but the central theme is ribosome biogenesis and initiation. ","confidence":"High","size":29,"edges":4,"triangles":0,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":7},{"id":"GO:0001731","count":5},{"id":"GO:0000462","count":5},{"id":"GO:0016575","count":5},{"id":"GO:0042254","count":5}]},{"hash":"1807087008870998711","title":"Bacterial DNA Repair and Oxidative Stress Response","description":"The top GO terms cluster around base-excision repair, DNA recombination, and cellular responses to hydrogen peroxide and xenobiotic stress, suggesting a common role in genome maintenance and oxidative stress adaptation in bacteria. Some terms like teichoic acid biosynthesis are more peripheral but don\u2019t override the core theme of DNA repair and stress response.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":7},{"id":"GO:0019350","count":5},{"id":"GO:0007568","count":5},{"id":"GO:1903507","count":4},{"id":"GO:0006310","count":4}]},{"hash":"1961603678946781416","title":"Developmental Patterning and Differentiation","description":"The GO terms cluster around tissue development and differentiation across multiple organs (cardiac atrial development, forebrain regionalization, visceral motor neuron differentiation, uterine epithelium development) along with cell-matrix adhesion and post-transcriptional regulation by miRNAs. This points to a group of proteins involved in coordinating developmental patterning and differentiation, with regulatory input from miRNA pathways and growth signaling, rather than a single tissue-specific process.","confidence":"High","size":29,"edges":57,"triangles":32,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:2000691","count":19},{"id":"GO:0055014","count":19},{"id":"GO:0021524","count":19},{"id":"GO:0035852","count":19},{"id":"GO:0021871","count":19}]},{"hash":"1534124196686813927","title":"Unknown","description":"The Top Terms include saliva secretion, dopaminergic synaptic transmission, sensory perception of pain, diet-induced thermogenesis, and cellular response to temperature stimulus, along with unrelated terms like regulation of blood pressure, T cell differentiation, and glomerular filtration. The terms span multiple organ systems with no clear, shared molecular function or pathway, so a single coherent label cannot be confidently assigned.","confidence":"","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":6},{"id":"GO:0001963","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0071502","count":6}]},{"hash":"2146149354897906866","title":"Neural development and GABAergic signaling","description":"This cluster centers on nervous system development and synaptic activity, with terms for midbrain morphogenesis, sensory perception of sound, and GABAergic synaptic transmission, suggesting a neural development/signaling theme. While insulin signaling, TORC2 signaling, and mitochondrial fission imply neuronal metabolism and signaling, an outlier term (B cell affinity maturation) is present but does not dominate the set. ","confidence":"Medium","size":29,"edges":35,"triangles":0,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0051932","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0000266","count":2}]},{"hash":"88311306925291782","title":"Nuclear transport and transcriptional regulation","description":"This cluster centers on regulation of gene expression via nuclear transport (NLS-bearing protein import), chromatin remodeling coupled to transcription initiation, and core promoter binding, with supporting involvement from signaling and cell cycle processes that shape transcriptional programs.","confidence":"Medium","size":29,"edges":5,"triangles":0,"max_degree":5,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0006607","count":9},{"id":"GO:0015991","count":8},{"id":"GO:0007050","count":8},{"id":"GO:0048096","count":6}]},{"hash":"513156832717733695","title":"Unknown","description":"The terms include paranodal junction assembly (neural), symbiont entry into host cell, T cell costimulation, receptor internalization, proteolysis, sensory detection of sound, integrin signaling, and several metabolic catabolic processes, indicating a highly diverse set with no clear, single function dominating the cluster.","confidence":"","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":8},{"id":"GO:0046718","count":7},{"id":"GO:0031295","count":6},{"id":"GO:0031623","count":6},{"id":"GO:0006508","count":6}]},{"hash":"141032220748484470","title":"Developmental organogenesis and morphogenesis","description":"The cluster shows a broad developmental theme, with terms spanning neural, skin, kidney, and lung organogenesis, tissue morphogenesis, and maintenance of organ identity; while some terms reflect general cellular processes like nuclear import and GTPase regulation, the dominant signal is developmental morphogenesis across multiple tissues.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006607","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0015991","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0051754","count":5}]},{"hash":"67828701828277447","title":"ECM-Integrin Signaling and Cytoskeletal Podosome Assembly","description":"This cluster centers on extracellular matrix and integrin-mediated signaling, including collagen-related receptor signaling, ECM-cell communication, and regulation of Rho/Ras pathways, which drive cytoskeletal rearrangements and podosome formation. The convergence on integrin signaling, MAPK/ERK cascades, and cytoskeletal dynamics supports a cohesive theme of cell adhesion and matrix-driven signaling.","confidence":"High","size":29,"edges":47,"triangles":30,"max_degree":10,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071226","count":22},{"id":"GO:0035023","count":20},{"id":"GO:0071803","count":19},{"id":"GO:0046580","count":19},{"id":"GO:0007229","count":19}]},{"hash":"510910664770244719","title":"Organogenesis across tissues","description":"The Top Terms indicate developmental and morphogenetic processes across diverse organs and tissues (heart, middle ear, spleen, digestive tract, prostate, insect visual primordium, neuromuscular development, dopaminergic neuron differentiation, etc.), suggesting a general theme of organogenesis and tissue patterning rather than a single pathway. This cluster appears to group proteins involved in broad developmental regulation across multiple contexts.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0000060","count":5},{"id":"GO:0042474","count":4},{"id":"GO:0001759","count":4},{"id":"GO:0001744","count":4}]},{"hash":"2184251726524570382","title":"Embryonic organogenesis","description":"This cluster is dominated by GO terms describing development and morphogenesis across multiple organs and tissues (inner ear, heart, placenta, thyroid, cerebellum, retina, skeletal muscle, cranial skeleton), indicating a shared role in embryonic organ formation rather than a single pathway. The broad but coherent theme across diverse organ systems supports labeling as embryonic organogenesis.","confidence":"High","size":29,"edges":95,"triangles":0,"max_degree":23,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0048839","count":12},{"id":"GO:0048701","count":12},{"id":"GO:0007601","count":12},{"id":"GO:0007519","count":12},{"id":"GO:0007507","count":12}]},{"hash":"2047843848789725113","title":"Cell cycle and transcriptional regulation","description":"The top GO terms cluster around nuclear processes and gene expression control: nuclear import, chromatin remodeling, transcription initiation and core promoter binding, and proteasome localization, all tied to regulation of the cell cycle. While a few terms appear unrelated (e.g., plant-symbiont-induced growth, papilla formation, cardiac conduction), the dominant theme is proliferation-linked transcriptional regulation and protein turnover.","confidence":"Medium","size":29,"edges":403,"triangles":3573,"max_degree":28,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":18},{"id":"GO:0007050","count":16},{"id":"GO:0080034","count":15},{"id":"GO:0006607","count":15},{"id":"GO:0031144","count":15}]},{"hash":"766423760462025766","title":"Innate immunity and developmental signaling","description":"This cluster shows a strong representation of innate immune processes: innate immune response, dsRNA and LPS signaling, xenophagy, and apoptotic pathways, along with ERK cascade-related signaling and growth factor\u2013associated pathways. The presence of development-related terms (multicellular organism development, nervous system development) suggests these proteins also participate in developmental signaling or cell\u2013signal integration, indicating a link between immune responses and developmental processes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0045087","count":15},{"id":"GO:0007160","count":14},{"id":"GO:0007275","count":14},{"id":"GO:1904417","count":14},{"id":"GO:0006915","count":14}]},{"hash":"1779545410430861335","title":"Placental and embryonic tissue morphogenesis","description":"The top GO terms are dominated by placental and embryonic development and tissue morphogenesis (e.g., placenta development, cartilage morphogenesis, left-right patterning, EMT in heart structures, and trophoblast differentiation), suggesting a cohesive theme around embryogenesis and placental/tissue formation. A few RNA-processing terms appear but are less representative of the main function. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":26},{"id":"GO:0060536","count":26},{"id":"GO:0060707","count":26},{"id":"GO:0060972","count":26},{"id":"GO:0035270","count":26}]},{"hash":"238602422526375321","title":"Transcription Regulation and Cell Cycle Control","description":"This cluster centers on transcription-related processes tied to RNA polymerase II (initiation, preinitiation complex assembly, DNA-templated transcription) and on cell cycle regulation (mitotic spindle pole separation, re-entry into mitosis). The presence of terms for transcription control and cell-cycle events dominates, with a couple of outliers (autophagy-related assembly and mammary gland development) that are less connected to the core theme but do not override the main signal.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0044828","count":3},{"id":"GO:0071157","count":3},{"id":"GO:0006367","count":2},{"id":"GO:0051123","count":2}]},{"hash":"2280006837609109287","title":"Cardiovascular and craniofacial development","description":"The top GO terms are centered on heart development and embryonic organogenesis, including pulmonary myocardium development and embryonic cranial skeleton morphogenesis, plus broader multicellular development and mesenchyme-related terms. This points to a cluster of proteins involved in cardiovascular and craniofacial morphogenesis and associated signaling (e.g., Rho regulation, FGF/PI3K-related signaling) during embryonic development. So the label \u201cCardiovascular and craniofacial development\u201d captures the dominant theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0048701","count":5},{"id":"GO:0003350","count":4}]},{"hash":"1954652230614962398","title":"Drosophila imaginal disc and appendage morphogenesis","description":"This cluster is dominated by GO terms describing wing disc patterning (proximal/distal and dorsal/ventral), imaginal disc-derived wing size regulation, wing and haltere development, eye morphogenesis, and associated muscle development/attachment, all pointing to morphogenesis of Drosophila appendages. High","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007473","count":1},{"id":"GO:0048190","count":1},{"id":"GO:0007451","count":1},{"id":"GO:0001745","count":1},{"id":"GO:0014032","count":1}]},{"hash":"2237675225563538522","title":"Developmental growth signaling via GTPases","description":"Proteins in this cluster are enriched for multicellular development, growth, and insulin-like growth factor receptor signaling, alongside several GTPase-regulated pathways (small GTPases, Rho signaling, and GTPase activity). This points to a cohesive role in developmental signaling and cytoskeletal regulation, with tissue-specific themes such as skin development and antiviral defense aligning under the broader growth/signaling framework.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0043588","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0035264","count":3}]},{"hash":"1256362837105984648","title":"Mitochondrial Energy Metabolism","description":"The cluster centers on mitochondrial electron transport and ATP synthesis, as shown by terms for the electron transport chain, proton motive force-driven ATP production, and related membrane transport. Some terms (translation, abscisic acid signaling, spermatogenesis) are less aligned and may reflect annotation noise or multi-function proteins, but the dominant theme is energy metabolism in mitochondria.","confidence":"Medium","size":28,"edges":360,"triangles":2844,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0016540","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0009738","count":2},{"id":"GO:0006123","count":2},{"id":"GO:0008584","count":2}]},{"hash":"462806083878734976","title":"Mitochondrial Translation and Oxidative Phosphorylation","description":"The cluster is enriched for both translation-related terms (cytoplasmic translation, translation, ribosomal large subunit assembly) and mitochondrial energy metabolism (mitochondrial electron transport, NADH to ubiquinone; ATP synthesis coupled electron transport; proton motive force-driven ATP synthesis) plus iron-sulfur cluster assembly, suggesting proteins involved in mitochondrial ribosome biogenesis and the assembly/function of the oxidative phosphorylation system. This combination points to a mitochondria-centered group coordinating protein synthesis machinery with respiratory chain/Fe-S biogenesis.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0015986","count":3},{"id":"GO:0016226","count":3},{"id":"GO:0042773","count":2},{"id":"GO:0021762","count":2}]},{"hash":"1557036285819308995","title":"Unknown","description":"The top GO terms cover neural and cardiac development, synaptic activity, xenobiotic response, and core cell-cycle processes, spanning tissues and functions that don\u2019t point to a single cohesive biological theme. Because the cluster appears to mix developmental programs with general cell-cycle machinery and stress responses, a unifying label is not evident.","confidence":"","size":28,"edges":8,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0014044","count":7},{"id":"GO:0042220","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0007507","count":6},{"id":"GO:0021766","count":6}]},{"hash":"1292531082759236745","title":"Unknown","description":"The GO terms span nervous-system myelin maintenance, fungal sphingolipid and sterol biosynthesis, sebaceous gland differentiation, nitrate assimilation, mitochondrial inheritance, lipid biosynthesis, nitric oxide production, GI epithelium maintenance, and T cell proliferation. This breadth suggests no single shared function or pathway linking the proteins, so a cohesive cluster label can't be determined.","confidence":"","size":28,"edges":37,"triangles":0,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0032286","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0000001","count":2}]},{"hash":"662686278577531989","title":"Cardiovascular and erythrocyte function under hypoxia","description":"The top GO terms cluster around heart development, erythrocyte maturation, and gas/oxidative stress handling (bicarbonate and nitric oxide transport; responses to hypoxia and hydrogen peroxide), suggesting a cohesive theme of cardiovascular biology and red blood cell physiology under stress. While there are additional processes like endocytosis and protein oligomerization, the dominant signals point to heart/blood function and oxygen-related adaptation.","confidence":"High","size":28,"edges":178,"triangles":484,"max_degree":25,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0007507","count":12},{"id":"GO:0009636","count":12},{"id":"GO:0001666","count":11},{"id":"GO:0043249","count":11},{"id":"GO:0051291","count":11}]},{"hash":"75832042831886860","title":"B and T cell receptor signaling with innate immunity","description":"The cluster shows a clear enrichment for adaptive immune signaling, including B cell receptor signaling, T cell receptor signaling, and B cell affinity maturation, along with innate immune responses such as response to lipopolysaccharide. Dendritic spine morphogenesis and heart development appear as peripheral terms, but the dominant theme centers on lymphocyte activation and innate immune pathways.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0060997","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0002344","count":4}]},{"hash":"1731416809671939665","title":"Arabinogalactan protein glycosylation and cell wall development","description":"This cluster is dominated by GO terms linked to plant cell wall biogenesis and AGP-related glycosylation, including arabinogalactan protein metabolic process, poly-N-acetyllactosamine biosynthetic process, and hydroxyproline O-linked glycosylation, along with root hair and seed coat mucilage development. These terms together suggest a cohesive theme around AGP-containing glycoproteins shaping cell wall structure and development; some insect-related terms appear less representative but do not override the plant-focused signal.","confidence":"High","size":28,"edges":109,"triangles":154,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":10},{"id":"GO:0071555","count":9},{"id":"GO:0042248","count":6},{"id":"GO:0007299","count":6},{"id":"GO:0001744","count":6}]},{"hash":"730082185497105280","title":"Ubiquitin-Mediated Innate Immunity","description":"This cluster centers on ubiquitination-related processes linked to innate immune signaling: innate immune response, defense against virus, TNF signaling, and K63-linked ubiquitination, plus protein autoubiquitination and ubiquitin-dependent ERAD. The presence of B cell homeostasis and spleen development hints at immune-related functions in lymphoid tissues, while NOS regulation and development terms may reflect downstream regulatory or context-dependent roles. Taken together, the proteins appear tied to ubiquitin-mediated control of immune responses, especially antiviral signaling.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0051865","count":6},{"id":"GO:0048536","count":6},{"id":"GO:0050999","count":5}]},{"hash":"968810202075904727","title":"Unknown","description":"The top GO terms span ion transport regulation, Rho signaling, heart development, filopodium assembly, adaptive immune response, collagen fibril organization, integrin signaling, proteolysis, insulin signaling, and B cell maturation. This mix points to diverse roles in ion homeostasis, cytoskeletal dynamics, development, ECM organization, and immune signaling, with no single cohesive function across the cluster. Therefore a concise, specific label is not evident.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010765","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0002250","count":4}]},{"hash":"1211033813746369811","title":"Embryonic organogenesis and angiogenesis","description":"The cluster is dominated by developmental terms: multicellular organism development, heart development, inner ear development, and cerebellar cortex formation, along with angiogenesis. Insulin receptor signaling also appears, suggesting metabolic regulation during development. Together these indicate a cohesive theme of embryonic organ formation and vascular growth, with signaling pathways guiding these processes. A few terms (like sensory perception of pain) are less directly aligned but can relate to neural development contexts, not overturning the overall developmental/vascular theme.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019233","count":20},{"id":"GO:0007275","count":20},{"id":"GO:0006349","count":20},{"id":"GO:0048839","count":20},{"id":"GO:0001525","count":19}]},{"hash":"1807459937187069333","title":"Rho GTPase signaling and angiogenesis","description":"The dominant GO terms point to regulation and activation of Rho family GTPases, which control cytoskeletal dynamics, together with positive regulation of angiogenesis and VEGF signaling. This suggests a cluster of proteins involved in actin remodeling linked to vascular growth, with dendritic spine morphogenesis reflecting shared cytoskeletal regulation. Confidence: High","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0001525","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0016567","count":4}]},{"hash":"915814635432080301","title":"Developmental Differentiation and Signaling","description":"The top GO terms cluster around developmental processes across tissues (heart, placenta, vagina, fat cell differentiation) and signaling pathways (p38 MAPK cascade, cellular response to retinoic acid) with DNA-templated transcription as a common theme. This suggests the proteins collectively participate in development and differentiation regulation via MAPK and retinoic acid signaling, rather than a single tissue-specific function.","confidence":"Medium","size":28,"edges":11,"triangles":4,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":16},{"id":"GO:0060068","count":16},{"id":"GO:0038066","count":16},{"id":"GO:0045444","count":16},{"id":"GO:0071300","count":16}]},{"hash":"2265974993617381526","title":"Xenobiotic Stress and Central Metabolism","description":"Top GO terms indicate a blend of xenobiotic response and core metabolic processes (glycolysis, carbohydrate phosphorylation, fructose-6-phosphate metabolism), with additional signals for biotin and antibiotic biosynthesis, and some RNA processing (mRNA capping, guanine-N7 methylation). The common thread appears to be cellular response to xenobiotics intertwined with central carbon metabolism, though RNA processing terms are less directly related. Confidence in a cohesive label is Medium.","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0035690","count":4},{"id":"GO:0036265","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0006370","count":4}]},{"hash":"1095179644514119627","title":"Planar polarity-driven axon guidance","description":"The cluster\u2019s top GO terms consistently point to planar cell polarity signaling and axon guidance, including dopaminergic and serotonergic neuron axon guidance and related cell adhesion processes, indicating proteins coordinating PCP with neuronal pathfinding. Some terms appear obsolete or less related (oxidation-reduction, brown fat differentiation), but the dominant theme is PCP-associated axon guidance.","confidence":"High","size":28,"edges":73,"triangles":81,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0007157","count":11},{"id":"GO:0017000","count":9},{"id":"GO:1904938","count":9},{"id":"GO:0050873","count":9}]},{"hash":"610614754610247173","title":"Adhesion-Driven neural and skeletal development","description":"This cluster centers on cell adhesion and adhesion-mediated signaling, including heterophilic/homophilic adhesion, receptor clustering, and integrin-mediated pathways, together with developmental processes such as nervous system and skeletal system development and ossification. The common thread is that cell-cell and cell-matrix adhesion events drive tissue development in both neural and skeletal contexts.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0051965","count":13},{"id":"GO:0007275","count":11},{"id":"GO:0007399","count":11},{"id":"GO:0043931","count":11}]},{"hash":"2191458033423527148","title":"Actin-based Protrusions and Cell Migration","description":"The cluster\u2019s dominant terms are about actin cytoskeleton remodeling and protrusion formation (filopodium, lamellipodium, microspike assemblies), plus activation of GTPases and positive regulation of cell spreading/adhesion, all key to cell migration. Some terms like Wnt signaling or morphogenesis appear as secondary associations and do not define the main theme here.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0043314","count":3},{"id":"GO:1904693","count":3},{"id":"GO:0030035","count":3}]},{"hash":"1735019134199774014","title":"Aerobic respiration and TCA cycle","description":"This cluster is dominated by GO terms tied to central energy production, including the TCA cycle, aerobic respiration, and the respiratory electron transport chain, suggesting a cohesive metabolism/energy-production theme. A few outliers (flagellum assembly, ethanol response, signaling regulation) appear, but the core signal points to respiration-related proteins.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":1},{"id":"GO:0044780","count":1},{"id":"GO:0009060","count":1},{"id":"GO:0022904","count":1},{"id":"GO:0045471","count":1}]},{"hash":"1661274775968423765","title":"Spliceosome-regulated mRNA splicing and processing","description":"The cluster's top GO terms center on regulation of splicing via the spliceosome (positive, negative, and alternative), along with mRNA export and translation initiation-related processes, pointing to a cohesive theme of RNA maturation and post-transcriptional gene expression. Some terms reference development or physiology, but the dominant signal is RNA processing, supporting this label.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0086091","count":3},{"id":"GO:0075525","count":3},{"id":"GO:0048025","count":3},{"id":"GO:0001825","count":3}]},{"hash":"100544168350189032","title":"Unknown","description":"The top GO terms span apoptosis, immune isotype switching, neuronal receptor regulation, and multiple developmental processes (placenta, cartilage, endocrine, pancreatic development, and EMT). There is no clear, single biological theme linking these terms, so a cohesive functional label cannot be assigned.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042771","count":3},{"id":"GO:0048298","count":3},{"id":"GO:0045190","count":3},{"id":"GO:0048304","count":3},{"id":"GO:2000311","count":2}]},{"hash":"554994083361357824","title":"Spliceosome-Driven mRNA Processing","description":"This cluster is strongly enriched for GO terms related to mRNA splicing (positive and negative regulation via the spliceosome, alternative splicing) as well as mRNA export and regulation of mRNA stability in response to stress, plus translation initiation complex formation. The common theme ties to post-transcriptional RNA processing and mRNA fate governed by spliceosome activity, indicating a coherent network of splicing regulation and mRNA maturation/export functions.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":27},{"id":"GO:0048026","count":22},{"id":"GO:0031047","count":22},{"id":"GO:0075525","count":21},{"id":"GO:0048025","count":21}]},{"hash":"1750901998250990145","title":"Vertebrate embryonic organ development","description":"GO terms point to embryonic organogenesis across skeletal/osteoblast, craniofacial (roof of mouth), retinal, and heart development, with regulatory transcription and proliferation control supporting coordinated developmental programs. While a few terms reflect general cellular functions, the strongest signal is embryonic development of multiple organs. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0048706","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0051262","count":2}]},{"hash":"496540829094764585","title":"KIT-Dependent Hematopoiesis and Innate Immunity","description":"These proteins cluster around KIT signaling and innate immune functions, with strong enrichment for innate immune response, neutrophil clearance, and myeloid progenitor differentiation, all tied to KIT's role in hematopoiesis and immune cell development. The presence of KIT signaling alongside these immune terms suggests a coherent theme of KIT-mediated regulation of immune lineage formation and function, with some additional KIT-associated roles in melanocyte migration and skeletal development that are consistent with the broader KIT signaling axis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014068","count":15},{"id":"GO:0045087","count":14},{"id":"GO:0051965","count":13},{"id":"GO:0038109","count":11},{"id":"GO:0038091","count":11}]},{"hash":"1300161447620754357","title":"Immune signaling and transcriptional regulation","description":"The top GO terms point to immune-related activity (response to LPS, B cell proliferation) and signaling plus gene regulation (positive regulation of GTPase and kinase activity, chromatin remodeling, and nuclear import). This suggests a cluster of proteins involved in initiating immune signaling and coordinating transcriptional changes, with additional hints of cell migration. Some terms (vacuole inheritance, organ identity maintenance) are less directly linked but may reflect broader cellular roles. Overall, a cohesive theme of immune signaling coupled to transcriptional regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0006607","count":5},{"id":"GO:0048496","count":5},{"id":"GO:0000011","count":5},{"id":"GO:0007026","count":4}]},{"hash":"362640340735481151","title":"Ubiquitin-Proteasome Proteolysis and Cell-Cycle Regulation","description":"Based on the top GO terms, the cluster is dominated by ubiquitin-dependent protein catabolic processes, especially SCF-dependent proteasomal degradation, indicating a strong proteostasis signature. The presence of cell-cycle\u2013related terms (mitotic G1 checkpoint signaling, regulation of DNA replication initiation) and circadian rhythm regulation suggests linkage between protein turnover and cell-cycle control. While some terms point to other processes, the core theme is ubiquitin-proteasome\u2013driven proteolysis coupled with cell-cycle regulation.","confidence":"High","size":28,"edges":4,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042787","count":24},{"id":"GO:0031146","count":22},{"id":"GO:0060386","count":20},{"id":"GO:1902916","count":20},{"id":"GO:0042752","count":20}]},{"hash":"1842223339004544062","title":"Cytoskeleton remodeling and cell adhesion signaling","description":"The cluster is enriched for GO terms centered on actin cytoskeleton reorganization, small GTPase\u2013mediated signaling, tight junction/podosome assembly, and pathways governing cell polarity and adhesion (ephrin and Wnt signaling), indicating a coherent group of proteins involved in cytoskeletal dynamics and cell\u2013cell interactions.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":12},{"id":"GO:0043552","count":10},{"id":"GO:0070830","count":10},{"id":"GO:0007264","count":10},{"id":"GO:0051835","count":9}]},{"hash":"1595594478966916206","title":"Neuronal development and synaptic plasticity with actin remodeling","description":"The cluster is dominated by neural-specific functions: nervous system development and long-term synaptic potentiation, complemented by actin cytoskeleton remodeling and crosslinking. Phosphatidylinositol-mediated signaling and Wnt signaling further support coordinated signaling during neuronal maturation and synapse formation. While there are some general cell cycle terms, the most prominent and specific terms point to neuronal development and synaptic plasticity supported by cytoskeletal dynamics, justifying this label.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":6},{"id":"GO:0048015","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0060291","count":4},{"id":"GO:0051764","count":4}]},{"hash":"1829251321830100182","title":"Steroid and related hormone biosynthesis cluster","description":"The top GO terms are dominated by biosynthetic processes for steroids and related hormones (estrogen, glucocorticoids, C21-steroid hormones), plus retinoic acid and fatty acid elongation, with a note on transcription regulation. This points to a cohesive theme of steroid/hormone and related metabolite biosynthesis and metabolism across the proteins.","confidence":"High","size":28,"edges":129,"triangles":170,"max_degree":16,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":25},{"id":"GO:0006703","count":24},{"id":"GO:0046677","count":24},{"id":"GO:0006704","count":24},{"id":"GO:0009710","count":24}]},{"hash":"1795350152923235470","title":"Ubiquitin-Dependent Antiviral Innate Immunity","description":"Dominant ubiquitin-dependent proteolysis terms, together with innate immune response and defense against virus terms, indicate a module where ubiquitin signaling and proteolysis regulate antiviral innate immunity. The presence of specific ubiquitination types (K63-linked, K6-linked) and related NF-kappaB signaling reinforces this link, with circadian rhythm regulation as an additional, possibly connected layer. Thus, the label captures the core function of the cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:0045087","count":13},{"id":"GO:0051607","count":11},{"id":"GO:0042752","count":10},{"id":"GO:0070534","count":9}]},{"hash":"1648090079213609812","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"This cluster centers on ubiquitination-driven processes, including various ubiquitin linkages (K6, K63) and ubiquitin-dependent protein catabolic processes, plus autoubiquitination and histone ubiquitination. The presence of terms related to TNF signaling and I-kappaB phosphorylation points to involvement in NF-\u03baB\u2013mediated pathways and apoptosis regulation. Overall, the proteins likely participate in ubiquitin-mediated protein turnover and signaling that modulates inflammatory responses and cell death.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0085020","count":15},{"id":"GO:0036205","count":15},{"id":"GO:1903265","count":15},{"id":"GO:0051865","count":15}]},{"hash":"2177303087497294794","title":"Chemokine signaling and immune cell migration","description":"The GO terms repeatedly emphasize chemokine production (CXCL1, MIP-1\u03b1) and macrophage-related signaling, along with cell migration and GPCR-mediated pathways. This points to a cluster of proteins involved in orchestrating chemokine-driven immune responses and movement of immune cells, rather than metabolism or structural roles. Some terms are obsolete or broad, but the core signal is immune chemokine signaling and migration.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:1904743","count":5},{"id":"GO:0071642","count":5},{"id":"GO:0072660","count":5},{"id":"GO:0016049","count":5}]},{"hash":"814052753449651478","title":"Growth signaling via GTPase and PKC pathways","description":"The cluster centers on signaling cascades involving GTPase activity (including Rac regulation), PKC signaling and GPCR/cAMP\u2013related responses, plus IGF receptor signaling and growth/development processes (cranial skeletal system development and multicellular growth). This points to a cohesive theme of growth-related signaling mediated by GTPases and PKC pathways, with broader developmental roles.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0090557","count":3},{"id":"GO:0051044","count":3},{"id":"GO:0051591","count":3},{"id":"GO:0007205","count":3}]},{"hash":"1457409636620547910","title":"Energy Production and Gene Expression","description":"This cluster\u2019s top GO terms center on energy metabolism (mitochondrial and chloroplast electron transport chains, proton transport, respiration) alongside core gene expression processes (DNA-templated transcription, translation) and transport. The combination suggests proteins linked to cellular energy production coupled with basic transcription/translation machinery, hence the label.","confidence":"Medium","size":27,"edges":349,"triangles":2876,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0019684","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1557088714007856064","title":"Mitochondrial Translation and Energy Metabolism","description":"The cluster shows a coherent theme around mitochondrial gene expression and respiration: mitochondrial translation and general translation, mitochondrial ribosome-related rRNA maturation, protein folding for proteostasis, and core energy pathways (NADH-to-ubiquinone electron transport and the TCA cycle). This points to a module combining mitochondrial protein synthesis machinery with energy metabolism.","confidence":"High","size":27,"edges":282,"triangles":1547,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006120","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1180291950342621629","title":"Developmental actin cytoskeleton remodeling","description":"Top terms emphasize actin cytoskeleton regulation (Arp2/3-mediated nucleation, barbed-end capping) and modulation of Rho-family GTPases, paired with developmental processes (multicellular growth, neuron projection and skin development). This points to a function cluster of proteins coordinating actin remodeling during development and tissue morphogenesis. ER stress\u2013related apoptotic signaling appears ancillary rather than core.","confidence":"Medium","size":27,"edges":6,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0050731","count":5},{"id":"GO:0031175","count":4}]},{"hash":"1049214861641394612","title":"Neural Sensory Processing and Reward Signaling","description":"This cluster is dominated by terms tied to neural sensing and processing (visual perception and learning, pain perception), dopaminergic synaptic transmission, and cocaine-related behavioral responses, all pointing to neural sensory-reward pathways. Signaling mechanisms like ERK cascade and GTPase regulation support this theme. Some terms (heart development, macrophage chemotaxis) appear as peripheral signals, suggesting pleiotropy, but the core signal remains neural sensory/reward processing.","confidence":"Medium","size":27,"edges":326,"triangles":2363,"max_degree":26,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":20},{"id":"GO:0007601","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0048148","count":18},{"id":"GO:0071380","count":18}]},{"hash":"503721991096934864","title":"Environmental sensing and cardiac signaling","description":"This cluster centers on environmental cue detection (CO2, aerotaxis, thermosensory behavior) alongside cardiac electrical activity (AV node action potential, ventricular repolarization, regulation of cardiac muscle hypertrophy). It\u2019s accompanied by signaling pathway modulation (guanylyl cyclase) and potassium transport, suggesting a theme of environmental sensing feeding into heart function. Some development/ossification terms appear as broader pleiotropic roles but do not dominate. ","confidence":"Medium","size":27,"edges":6,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010754","count":19},{"id":"GO:0003031","count":19},{"id":"GO:0009454","count":19},{"id":"GO:0040040","count":19},{"id":"GO:0071805","count":18}]},{"hash":"1406971347818658073","title":"DNA Damage Response and Replication Stress","description":"The cluster centers on DNA replication, base-excision repair, processing of mitotic/recombination intermediates, replication fork processing, and cellular responses to replication stress (e.g., hydroxyurea) with involvement in mitotic checkpoints. While it also includes sperm development and immunoglobulin hypermutation terms, the predominant theme ties to maintaining genomic integrity during replication and cell division.","confidence":"High","size":27,"edges":71,"triangles":62,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090267","count":6},{"id":"GO:0006284","count":6},{"id":"GO:0071140","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0009636","count":5}]},{"hash":"952789307744122994","title":"Neural and cardiac tissue development","description":"This cluster\u2019s prominent terms center on tissue morphogenesis and development in neural/nerve-associated tissues (photoreceptor morphogenesis, Schwann cell development) and the heart (ventricular cardiac muscle morphogenesis), together with signaling pathways like calcineurin-NFAT and cAMP that govern these processes. The presence of ion-channel clustering further supports excitable tissue function. While some terms are broader (membrane remodeling, chromatin regulation, xenobiotic response, cell-cycle transitions), the strongest signal is development and signaling in neural/nerve and cardiac contexts, making this a cohesive developmental theme for the cluster.","confidence":"Medium","size":27,"edges":66,"triangles":14,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043950","count":16},{"id":"GO:0033173","count":16},{"id":"GO:0008594","count":16},{"id":"GO:1903525","count":16},{"id":"GO:0035562","count":16}]},{"hash":"677339986669574748","title":"Hippocampal development and synaptic signaling","description":"The most represented GO terms point to neuronal development and synaptic function: hippocampus development, excitatory postsynaptic potential, ephrin receptor signaling, and Wnt signaling are prominent. This suggests a cluster centered on neuronal differentiation and intercellular signaling at synapses, with other terms reflecting general cellular processes that are less defining for the cluster. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":19},{"id":"GO:0006813","count":18},{"id":"GO:0006351","count":18},{"id":"GO:0048013","count":17},{"id":"GO:0000186","count":17}]},{"hash":"1452089890946383951","title":"Neural development and axon guidance","description":"The cluster is enriched for neural development terms (nervous system development, retina morphogenesis, nerve impulse transmission) and axon-guidance pathways (Roundabout, Hedgehog/Smoothened). Additional themes include dendrite self-avoidance and ion-channel clustering, suggesting a cohesive role in neuronal growth, patterning, and excitability, with some broader developmental cues (e.g., kidney development) that can share signaling contexts.","confidence":"High","size":27,"edges":302,"triangles":1904,"max_degree":26,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007224","count":15},{"id":"GO:0007399","count":15},{"id":"GO:0001822","count":15},{"id":"GO:0035385","count":15},{"id":"GO:0048671","count":14}]},{"hash":"1709530602100258180","title":"Unknown","description":"The GO terms span stress responses, RNA processing, metabolism, and cell cycle signals with no single dominant function linking the proteins, plus no interactions (edges). This dispersion makes a cohesive cluster label inappropriate.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0006400","count":3},{"id":"GO:0070651","count":3},{"id":"GO:0009636","count":3}]},{"hash":"79288537486747011","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":294,"triangles":2030,"max_degree":26,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":17},{"id":"GO:0031047","count":16},{"id":"GO:0000398","count":15},{"id":"GO:0000464","count":14},{"id":"GO:0034476","count":13}]},{"hash":"373151572627591851","title":"Protein tyrosine phosphatases and signaling regulators","description":"The cluster centers on peptidyl-tyrosine dephosphorylation and negative regulation of major signaling pathways such as MAPK/ERK, T cell receptor signaling, and PI3K/AKT, implying involvement of protein tyrosine phosphatases and related regulators that tune phosphorylation-dependent signaling. Additional terms like postsynaptic density assembly and kinetochore localization suggest these regulators function at signaling hubs across diverse cellular contexts, reinforcing a theme of phosphorylation-state control. Overall, the common thread is phosphatase-mediated regulation of signaling networks.","confidence":"High","size":27,"edges":139,"triangles":307,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":18},{"id":"GO:0035335","count":18},{"id":"GO:0050860","count":18},{"id":"GO:0000200","count":18},{"id":"GO:0034501","count":13}]},{"hash":"1484017844438082104","title":"Vascular and Neural Development Signaling","description":"The terms point to both vascular morphogenesis (coronary/renal artery development and VEGF receptor signaling) and diverse neural development processes (axonogenesis, neuronal migration, axon guidance, cerebellar Purkinje layer development, and synaptic plasticity regulation). The inclusion of Hedgehog pathway regulation (Smoothened) and broad developmental terms like single fertilization supports a cohesive developmental program rather than a single specific pathway. Overall, the cluster appears to capture intertwined vascular and neural developmental signaling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048010","count":5},{"id":"GO:0060385","count":4},{"id":"GO:0021828","count":4},{"id":"GO:0060982","count":4},{"id":"GO:0061441","count":4}]},{"hash":"39771188590965202","title":"Developmental transcription regulators","description":"This cluster is enriched for broad developmental processes (multicellular organism development, organ development) and transcription-related terms (transcription by RNA polymerase II, negative regulation of transcription), suggesting proteins that regulate gene expression during vertebrate organogenesis such as pancreas and brain development.","confidence":"High","size":27,"edges":229,"triangles":820,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":15},{"id":"GO:0007275","count":15},{"id":"GO:0021983","count":15},{"id":"GO:0006366","count":15},{"id":"GO:0003322","count":13}]},{"hash":"1210922585471218894","title":"Immune Defense and Organogenesis","description":"The cluster features strong representation of innate immune response and defense against virus through GO terms like defense response to virus, innate immune response, and cytokine-mediated signaling. It also shows multiple development-related terms across organs (metanephric tubule, lymph vessel, corpus callosum, bone development), suggesting a group of proteins involved in immune signaling together with tissue morphogenesis. Overall, the theme combines immune function with organ development, indicating a functionally cohesive but broad developmental-immunity cluster.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051607","count":10},{"id":"GO:0072287","count":10},{"id":"GO:0072237","count":10},{"id":"GO:0048846","count":10},{"id":"GO:0036303","count":10}]},{"hash":"2193905710431285954","title":"Developmental patterning and organogenesis","description":"The terms cluster around organismal development and tissue patterning (gonad, retina, anterior/posterior patterning, multicellular development) with signals regulating transcription and cytoskeletal remodeling (actin organization, cell migration). The inclusion of apoptotic processes and organelle-related fission suggests morphogenesis and remodeling during development. Confidence in a cohesive developmental/morphogenetic theme is Moderate to High, but the mix of broad terms warrants a cautious Medium. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0050731","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0006355","count":3}]},{"hash":"937733072924635419","title":"Glutamatergic synapse signaling and actin remodeling","description":"These proteins cluster around excitatory synaptic signaling (glutamatergic transmission and excitatory postsynaptic potentials) and cytoskeletal dynamics (Rho GTPase signaling, lamellipodium assembly, positive regulation of GTPase activity), suggesting a common role in regulating glutamatergic synapses through actin remodeling. Immune-related terms present in the list are likely peripheral noise relative to the dominant neuronal/synaptic theme. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0060079","count":5},{"id":"GO:0048538","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0030032","count":4}]},{"hash":"85241016461594941","title":"Developmental transcriptional regulation and ubiquitination","description":"The cluster features GO terms centered on transcription by RNA polymerase II and its regulation, protein ubiquitination, and several developmental processes (cartilage morphogenesis, placenta development, endocrine system development, EMT in heart development). This combination suggests the proteins collectively participate in regulating gene expression and post-translational modification during development.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":4},{"id":"GO:0031397","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0006366","count":3}]},{"hash":"1917473434107302772","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001731","count":18},{"id":"GO:0002188","count":18},{"id":"GO:0000398","count":14},{"id":"GO:0000462","count":13},{"id":"GO:0042273","count":13}]},{"hash":"1251336388927786063","title":"RNA Processing and Ribosome Biogenesis with Antiviral Response","description":"This cluster is dominated by RNA- and protein-synthesis\u2013related processes (translation, ribosome biogenesis, rRNA catabolic process) and RNA interference (siRNA processing), complemented by antiviral signaling (response to interferon-alpha, negative regulation of viral genome replication). While some terms touch on proliferation or development, the core theme ties RNA metabolism with antiviral responses.","confidence":"High","size":27,"edges":291,"triangles":1769,"max_degree":26,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0042254","count":7},{"id":"GO:0035455","count":7},{"id":"GO:0045071","count":7},{"id":"GO:0007049","count":5}]},{"hash":"1575072395316672508","title":"Developmental cell adhesion and morphogenesis","description":"This cluster shows strong representation of cell-cell adhesion terms (heterophilic and homophilic adhesion) along with multicellular organism development, nervous system development, nerve maturation, and branching morphogenesis (e.g., salivary gland). These together point to processes guiding tissue formation and organ development, with bone ossification also suggesting skeletal development. A single outlier about symbiont entry into host cells does not outweigh the dominant developmental/morphogenetic theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":16},{"id":"GO:0043931","count":13},{"id":"GO:0007156","count":11},{"id":"GO:0046718","count":11},{"id":"GO:0032516","count":11}]},{"hash":"134152183758806860","title":"Rho GTPase signaling and lamellipodium assembly in development","description":"GO terms emphasize regulation of Rho signaling, GTPase activation, and lamellipodium assembly, indicating actin cytoskeleton remodeling driving cell motility. The presence of multiple developmental processes (heart, spinal cord, midbrain morphogenesis, germ cell development, blood vessel remodeling) suggests this cluster reflects Rho GTPase\u2013mediated morphogenesis via lamellipodial dynamics.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0030032","count":6},{"id":"GO:0007281","count":5},{"id":"GO:1904693","count":5},{"id":"GO:0043314","count":5}]},{"hash":"2163950427056933598","title":"Angiogenesis and ECM remodeling","description":"The cluster shows strong representation of angiogenesis-related terms (angiogenesis, positive regulation of angiogenesis) along with collagen fibril organization and fibrinolysis, indicating a shared function in vascular development and extracellular matrix remodeling. Additional terms about endothelial cell survival and exocytosis/synaptic transmission suggest secretory or vascular/intercellular communication roles, but the dominant pattern is angiogenic and ECM remodeling processes.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045921","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0090331","count":4},{"id":"GO:0051968","count":4}]},{"hash":"1739906717622069365","title":"Spliceosome and translation initiation control","description":"The top terms cluster around formation of the translation preinitiation complex, translation reinitiation, and regulation of translational initiation, along with mRNA splicing via the spliceosome and related regulatory processes. This points to a cohesive theme of RNA processing and control of translation, with a secondary note that some terms touch on antiviral/defense contexts, which may reflect broader stress-related roles. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":10},{"id":"GO:0002188","count":10},{"id":"GO:0045292","count":10},{"id":"GO:0006378","count":9},{"id":"GO:0050830","count":9}]},{"hash":"1964346601625197987","title":"Ubiquitin-regulated innate immune response","description":"The terms cluster around innate immunity and antiviral defense, with strong signals for ubiquitin-dependent protein catabolic processes and autoubiquitination, TNF signaling, and apoptosis regulation, suggesting a module of proteins that regulate immune responses via ubiquitin-mediated turnover and signaling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":18},{"id":"GO:0042787","count":18},{"id":"GO:0051607","count":17},{"id":"GO:0033280","count":16},{"id":"GO:1903762","count":16}]},{"hash":"1413696483811276972","title":"Embryonic development and tissue morphogenesis","description":"The proteins show enrichment across diverse developmental and morphogenesis processes (ear, hair, cartilage, endocrine system, placenta/EMT, synapse formation, blood-related development), indicating a broad developmental theme rather than a single pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0048839","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0031069","count":5}]},{"hash":"2037777735912676020","title":"Neurodevelopment and Tissue Differentiation","description":"This cluster centers on development and tissue differentiation, notably neural development (axonogenesis, radial glia\u2013guided migration) alongside vascular and organ-specific differentiation (angiogenesis, lung and muscle differentiation). The presence of cytokine signaling and endosome transport suggests supporting cellular communication and trafficking during differentiation. Together, the terms reflect a cohesive theme of embryonic development and morphogenesis rather than a single pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0001525","count":7},{"id":"GO:0007409","count":6},{"id":"GO:0042694","count":6},{"id":"GO:0060487","count":6},{"id":"GO:2000643","count":6}]},{"hash":"1890926997396292260","title":"Cardiac sarcomere organization and contraction","description":"GO terms in the cluster heavily point to sarcomere organization and cardiac muscle function (e.g., cardiac muscle contraction, heart-rate regulation, sarcomere organization), suggesting proteins involved in heart muscle structure and activity. A few outlier terms (spicule insertion, Hedgehog pathway regulation, kidney morphogenesis) are less represented and do not define the cluster. Therefore, the label reflects the core theme of cardiac muscle structure and function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0045880","count":3},{"id":"GO:0034609","count":3},{"id":"GO:0060298","count":3}]},{"hash":"1060838470801149194","title":"Oxidative stress detoxification and redox homeostasis","description":"This cluster is dominated by GO terms for cellular oxidant detoxification and redox homeostasis, with additional enrichment for responses to toxic substances and related metabolic processes. The recurring redox-related functions suggest a cohesive theme around detoxification of reactive species and maintenance of redox balance, with supporting terms touching on metabolism and DNA repair that can be connected to oxidative stress responses. The platelet aggregation term is less central and may reflect broader or incidental annotations, but the core signal points to redox detox and protection against oxidative damage.","confidence":"High","size":26,"edges":321,"triangles":2507,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":14},{"id":"GO:0045454","count":11},{"id":"GO:0070527","count":11},{"id":"GO:0009072","count":7},{"id":"GO:0009407","count":7}]},{"hash":"1403869831295664526","title":"Retinoid and prostaglandin metabolism with hormonal signaling","description":"The top GO terms are dominated by retinol/retinal metabolic processes and prostaglandin biosynthesis, with additional signals pointing to hormonal regulation (testosterone biosynthesis), renal water homeostasis, and PI3K/AKT-related signaling, plus some drug metabolism. This pattern suggests a cluster centered on metabolism of retinoids and lipid-derived mediators with associated hormonal signaling and kidney-related functions.","confidence":"Medium","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042572","count":22},{"id":"GO:0042574","count":19},{"id":"GO:0046370","count":16},{"id":"GO:0055114","count":16},{"id":"GO:0048661","count":14}]},{"hash":"1498554320550905600","title":"Neural development and forebrain specification","description":"The terms predominantly describe neural development and brain region specification (forebrain, subpallium, and peripheral nervous system neuron development), with regulatory processes such as glial differentiation. While a few terms reference other organ developments, the dominant signal is brain patterning and neural differentiation.","confidence":"High","size":26,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0021920","count":4},{"id":"GO:0003322","count":4},{"id":"GO:0021905","count":4},{"id":"GO:0060435","count":4},{"id":"GO:1902723","count":4}]},{"hash":"2178970231558382859","title":"Dopaminergic Neural Signaling and Visual Processing","description":"The top GO terms are strongly centered on neural and sensory functions, including dopaminergic synaptic transmission, visual perception and visual learning, and behavioral responses to cocaine. While a few terms touch on immune or non-neural processes (e.g., macrophage chemotaxis, dsRNA response), the dominant theme is brain-related signaling and sensory processing, justifying a label focused on dopaminergic neural signaling and vision.","confidence":"Medium","size":26,"edges":312,"triangles":2321,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048148","count":18},{"id":"GO:0007601","count":18},{"id":"GO:0071380","count":18},{"id":"GO:0007507","count":18},{"id":"GO:0001963","count":18}]},{"hash":"858383681545634961","title":"CNS axon guidance and synapse formation","description":"The dominant GO terms center on axon guidance, neuron migration, and synapse assembly in the CNS (retinal ganglion cell axon guidance, paranode localization, CNS projection neuron axonogenesis, Roundabout signaling). While there are a couple of ECM/heart-related terms, the strongest signal reflects neural wiring and synapse formation, suggesting these proteins function together in CNS connectivity. ","confidence":"High","size":26,"edges":49,"triangles":33,"max_degree":18,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0031290","count":15},{"id":"GO:0002175","count":14},{"id":"GO:0051965","count":13},{"id":"GO:0021836","count":13},{"id":"GO:0035385","count":13}]},{"hash":"2120783722225861923","title":"Innate Immune Signaling and Cytotoxic Regulation","description":"The top GO terms cluster around innate immune response, antiviral defense, and cytokine signaling, with several entries indicating regulation of immune cell activity (macrophages, NK cells, and cytotoxic T cells) and cell\u2013cell interactions. This pattern points to a coherent immune signaling program that modulates cytotoxic and defense functions in the host, hence the label focusing on innate immunity and cytotoxic regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0019221","count":9},{"id":"GO:0051607","count":9},{"id":"GO:0046718","count":8},{"id":"GO:0007156","count":8}]},{"hash":"1585200434198899192","title":"Nucleolar ribosome biogenesis and export","description":"This cluster is dominated by GO terms for ribosome biogenesis and translation, plus subunit export from the nucleus, nuclear pore complex assembly, and mRNA export, which together indicate roles in ribosome assembly and nucleocytoplasmic transport of RNA. Some terms (e.g., kinetochore localization and transcription) are consistent with broader nuclear processes linked to ribosome production and RNA processing.","confidence":"High","size":26,"edges":190,"triangles":633,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0006412","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0051292","count":4}]},{"hash":"587846935308861533","title":"Sensory Neuronal Signaling","description":"This cluster is enriched for GO terms tied to sensory perception and neuronal communication, such as visual perception, pain perception, and dopaminergic synaptic transmission, along with responses to various stimuli (glucose, prostaglandin) that commonly engage neural circuits. A subset of terms relates to immune signaling, but the dominant pattern points to neural signaling and sensory processing. Confidence in this being the core theme is Medium.","confidence":"Medium","size":26,"edges":128,"triangles":237,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071333","count":17},{"id":"GO:0035994","count":17},{"id":"GO:0043330","count":17},{"id":"GO:0019233","count":16},{"id":"GO:0007601","count":16}]},{"hash":"1065753288118062483","title":"GPCR-cAMP Signaling and Blood Pressure Regulation","description":"The top GO terms point to an adenylate cyclase-activating GPCR signaling pathway and activation of adenylyl cyclase, coupled with positive regulation of blood pressure and renin-angiotensin\u2013related blood pressure control, suggesting a cluster of proteins involved in GPCR-mediated cAMP signaling that governs cardiovascular and renal function. While an outlier term (electron transport chain) appears, the dominant pattern is GPCR/cAMP signaling linked to blood pressure regulation and kidney filtration processes, making this a coherent cardiovascular signaling cluster. ","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0007190","count":25},{"id":"GO:0043950","count":18}]},{"hash":"291833974617845077","title":"Heart morphogenesis and SA node signaling","description":"The cluster includes GO terms tied to cardiac development and electrical rhythm, such as right atrium morphogenesis, Notch signaling in heart field cardioblasts, and regulation of SA node cell action potential, suggesting a cohesive theme around heart formation and pacemaker signaling. Additional terms like venous endothelial differentiation and GPCR signaling reflect supportive cardiovascular development contexts, with some broad regulatory processes (ubiquitination, mechanical response) accompanying the core cardiac-focused terms.","confidence":"High","size":26,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0007205","count":3},{"id":"GO:0060843","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0003270","count":3}]},{"hash":"829916083757348423","title":"Embryonic Morphogenesis and Organ Development","description":"This cluster is enriched for various morphogenesis and developmental GO terms across multiple tissues (eye, hindlimb, heart, placenta, prostate, habenula), indicating functions tied to embryonic development and tissue patterning. The presence of a transcriptional regulation term (negative regulation of transcription by RNA Pol II) suggests a broader role in controlling gene expression during development. Overall, the proteins likely participate in developmental programs rather than a single pathway.","confidence":"Medium","size":26,"edges":52,"triangles":5,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0048048","count":11},{"id":"GO:0021986","count":11},{"id":"GO:0060527","count":10},{"id":"GO:2000288","count":10}]},{"hash":"1353974464945531877","title":"Neural development and cell fate specification","description":"Many terms point to neural development and lineage specification (interneuron differentiation, motor neuron and oligodendrocyte fate, subpallium commitment). There are also endocrine pancreas development and general transcription regulation terms, suggesting broad developmental control. Overall, the cluster seems to group proteins involved in neural tissue patterning and cell fate decisions. Confidence: High","confidence":"","size":26,"edges":307,"triangles":2212,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":17},{"id":"GO:0045668","count":17},{"id":"GO:0006366","count":17},{"id":"GO:0060766","count":17},{"id":"GO:0060435","count":16}]},{"hash":"1380323046488166786","title":"Developmental gene expression and DNA replication","description":"This cluster combines core nuclear processes (DNA replication, DNA-templated transcription, mRNA export, mitotic cell cycle) with broad developmental themes (forebrain, neural tube closure, skeletal system, multicellular organism development), suggesting proteins involved in regulating gene expression and genome maintenance during development.","confidence":"Medium","size":26,"edges":226,"triangles":1113,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0030900","count":6},{"id":"GO:0032436","count":6},{"id":"GO:0006406","count":5}]},{"hash":"395026692663897606","title":"Angiogenesis and vascular remodeling regulators","description":"The terms cluster around regulation of angiogenesis (positive and negative), vascular permeability, endothelial cell survival, nitric oxide production, and collagen fibril organization, suggesting a group of proteins coordinating blood vessel formation, barrier function, and extracellular matrix remodeling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":7},{"id":"GO:0030199","count":6},{"id":"GO:0043116","count":5},{"id":"GO:2000352","count":5},{"id":"GO:0014068","count":5}]},{"hash":"1444715123165331417","title":"Inflammation- and apoptosis-related stress signaling","description":"This cluster centers on cellular stress responses that link inflammatory signaling (TNF, NF-kappaB, LPS response) with apoptosis pathways (p53-mediated, JNK regulation, TGF-beta response) and even DNA repair hints, suggesting a cohesive theme of stress-induced cell fate decisions and immune handling of damaged cells. A few outlier terms (e.g., X inactivation) are present but do not alter the main signal.","confidence":"High","size":26,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":4},{"id":"GO:0042771","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0071560","count":3},{"id":"GO:1905053","count":3}]},{"hash":"193901472924912696","title":"Immune signaling and tissue remodeling","description":"The top GO terms converge on inflammatory/immune signaling (IL-1\u03b2 production; PI3K/AKT pathway), metabolic upregulation (glycolysis), and tissue remodeling processes (bone resorption, blood coagulation) with tissue homeostasis, suggesting a coordinated immune-regulated remodeling program. An outlier term (sensory perception of sound) is present but does not override the dominant theme.","confidence":"Medium","size":26,"edges":63,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006919","count":4},{"id":"GO:0048873","count":4},{"id":"GO:0050718","count":4},{"id":"GO:0045124","count":3},{"id":"GO:0010765","count":3}]},{"hash":"1634233566538032278","title":"Neurocranial Development and Cell Migration","description":"This cluster is enriched in nervous system and craniofacial development terms (nervous system development, spinal cord development, cranial skeletal system development, roof of mouth development, left/right pattern formation) plus regulation of actin cytoskeleton and cell migration, suggesting a cohesive theme of morphogenesis guided by cytoskeletal dynamics.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0090138","count":4},{"id":"GO:0007399","count":3},{"id":"GO:1904888","count":3},{"id":"GO:0060972","count":3}]},{"hash":"1167159174517726274","title":"N- and Polyamine-Acetylation Cluster","description":"The top GO terms show a clear enrichment for various acetylation-related processes: peptidyl-lysine N6-acetylation, several N-terminal acetylation/propionylation terms, and acetylation of spermine and putrescine. While there are a few other terms (angiogenesis, subtelomeric heterochromatin formation, arginine and mycothiol biosynthesis, centromeric cohesion), the strongest and most cohesive signal is post-translational acetylation and related modifications, suggesting a functional cluster around acetylation enzymes and their substrates.","confidence":"High","size":26,"edges":9,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001525","count":10},{"id":"GO:0006348","count":8},{"id":"GO:0018003","count":8},{"id":"GO:0010125","count":7},{"id":"GO:0061606","count":7}]},{"hash":"1559627412985838721","title":"RNA Processing and Transcription Regulation","description":"The top GO terms are dominated by RNA processing (mRNA processing, RNase MRP-dependent mRNA decay, snoRNA processing) and transcription initiation/regulation by RNA polymerase II and III, indicating a core role in RNA maturation and gene expression control. Some terms also touch on DNA integration/proviral latency and SMAD signaling, likely reflecting broader or pleiotropic functions of the proteins rather than a single cohesive process, but the strongest signal centers on RNA processing and transcription regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0000294","count":2},{"id":"GO:0034965","count":2},{"id":"GO:0006397","count":2}]},{"hash":"141966661468740907","title":"Embryonic Organ and Nervous System Development","description":"These proteins show a cohesive pattern around broad embryonic development across multiple organs and neural-related structures. Top GO terms span heart development, placenta and skeletal muscle development, cerebellum and visual system formation, inner ear development, retinal ganglion cell guidance, and general multicellular organism development. The clustering points to a core role in coordinating organogenesis and neural/sensory system formation during development, rather than a single pathway. ","confidence":"High","size":26,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0048701","count":9},{"id":"GO:0048839","count":9},{"id":"GO:0007275","count":8},{"id":"GO:0031290","count":8}]},{"hash":"1393113054120668159","title":"Eye and brain development","description":"The top GO terms cluster around embryonic eye morphogenesis and camera-type eye development, plus midbrain development, rhombomere development, brain segmentation, peripheral nervous system neuron development, and inner ear development, indicating a cohesive program of neural and sensory organ morphogenesis. The presence of transcriptional regulation terms (RNA Pol II) suggests coordinated gene expression control during this developmental process. Together, these terms point to a coherent theme of neural and sensory organ morphogenesis in vertebrates.","confidence":"High","size":26,"edges":12,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":16},{"id":"GO:0006366","count":13},{"id":"GO:0048048","count":12},{"id":"GO:0021571","count":12},{"id":"GO:0030901","count":12}]},{"hash":"1047210622797220357","title":"Paranodal axon junction and adhesion proteins","description":"The cluster shows strong terms for cell\u2013cell adhesion (homophilic/heterophilic adhesion), paranodal junction assembly, and protein localization to the juxtaparanode region of the axon, indicating a function in organizing axonal membranes at nodes of Ranvier. While there are also terms related to signaling (Notch processing) and differentiation (keratinocyte differentiation), the clearest common theme is neuronal adhesion and paranodal/juxtaparanodal junctions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0034612","count":9},{"id":"GO:0007220","count":9},{"id":"GO:0030216","count":9},{"id":"GO:0010042","count":9},{"id":"GO:0055114","count":9}]},{"hash":"1882555428401319299","title":"Embryonic Development and Morphogenesis","description":"The cluster is enriched for terms related to embryonic development, including placenta/trophoblast differentiation, heart development, cartilage morphogenesis, and left-right patterning, suggesting a cohesive role in organogenesis. Additional terms on transcriptional regulation and DNA damage response reflect gene control and genome integrity during development, supporting a developmental, morphogenesis-focused theme.","confidence":"High","size":26,"edges":31,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0006351","count":2},{"id":"GO:2000134","count":2},{"id":"GO:0008630","count":2},{"id":"GO:0045944","count":2}]},{"hash":"384483878763533708","title":"Embryonic morphogenesis and organ development","description":"This cluster is enriched for embryonic development and morphogenesis across diverse tissues: neural crest cell migration, peripheral nervous system neuron development, roof of the mouth development, primitive streak formation, endocrine pancreas development, embryonic digestive tract morphogenesis, and cartilage development, plus ureteric bud branching. The combination of tissue-specific developmental terms with transcriptional regulation (DNA-templated transcription and negative regulation of transcription by RNA polymerase II) suggests these proteins act as regulators orchestrating early embryogenesis and organogenesis rather than a single pathway.","confidence":"High","size":26,"edges":33,"triangles":2,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0001755","count":10},{"id":"GO:0031018","count":9},{"id":"GO:0048557","count":9},{"id":"GO:0090190","count":9}]},{"hash":"1910939723471441220","title":"Developmental patterning and hormone signaling","description":"The top GO terms point to developmental patterning processes (forebrain regionalization, ectoderm formation, anterior head development) and hormone-related signaling (growth hormone receptor signaling, thyroid hormone response), with additional regulatory processes like miRNA-mediated silencing and endocytic recycling. This combination suggests a cluster centered on developmental patterning coordinated by hormone signaling, with shared regulatory mechanisms across multiple tissues. ","confidence":"Medium","size":26,"edges":16,"triangles":11,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060396","count":7},{"id":"GO:0021871","count":7},{"id":"GO:0035195","count":7},{"id":"GO:0003324","count":7},{"id":"GO:2000744","count":7}]},{"hash":"1990951939560868383","title":"Neural GPCR signaling and opioid response","description":"This cluster appears enriched for brain-related processes: response to morphine, regulation of GPCR signaling, and striatum development, pointing to neural signaling roles. Other terms touch on cellular structure and division (microtubule anchoring at centrosome, mitotic transition) that can relate to neuronal development and intracellular transport. Overall, the dominant theme is brain opioid signaling and neural regulation, with peripheral stress-related responses.","confidence":"Medium","size":26,"edges":22,"triangles":1,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0043278","count":6},{"id":"GO:0070301","count":5},{"id":"GO:0034454","count":5},{"id":"GO:0010288","count":5},{"id":"GO:0045842","count":5}]},{"hash":"1278572075579439058","title":"Calcium-regulated muscle contraction signaling","description":"The top terms are dominated by calcium handling and muscle function, including regulation of calcium release into the cytosol, cardiac and skeletal muscle contraction, and calcium-dependent signaling. Some terms (retina development, mitotic cell cycle) are less cohesive, but the prominent theme reflects calcium-mediated regulation of muscle activity and related pathways.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":10},{"id":"GO:0010842","count":9},{"id":"GO:0098735","count":9},{"id":"GO:0051281","count":9},{"id":"GO:1900242","count":9}]},{"hash":"1474072473466482028","title":"Developmental Signaling and Morphogenesis","description":"The cluster\u2019s GO terms span kinase signaling regulation (negative regulation of protein kinase activity; positive regulation of phosphorylation; calcium release) alongside development- and morphogenesis-related processes (face morphogenesis, axonogenesis, visual perception). Although there are gamete-interaction terms (sperm binding to zona pellucida, acrosome reaction), the common thread appears to be signaling pathways that coordinate developmental outcomes and morphogenesis, suggesting a cohesive though broad functional theme.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":5},{"id":"GO:0060325","count":5},{"id":"GO:0007339","count":4},{"id":"GO:0060046","count":4},{"id":"GO:0007409","count":3}]},{"hash":"494573607682418840","title":"Developmental transcription regulators","description":"Based on GO terms, the cluster is enriched for DNA-templated transcription and regulation of transcription by RNA polymerase II, plus multiple development-related terms (neural tube, spinal cord, brain, lens, osteoblast, gonad). This pattern points to proteins acting as transcription regulators involved in embryonic development across multiple tissues.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0001843","count":5},{"id":"GO:0006355","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0021510","count":5}]},{"hash":"265273298009850399","title":"Angiogenesis and Mesoderm Development","description":"This cluster is strongly enriched for angiogenesis (GO:0001525) and mesoderm formation (GO:0001707), suggesting involvement in vascular and mesodermal development. Additional terms point to transcriptional regulation, VEGF-related signaling, stem cell differentiation, and cellular responses such as nitric oxide signaling, all of which together support a coherent endothelial/mesodermal differentiation and vessel-formation program.","confidence":"High","size":26,"edges":181,"triangles":613,"max_degree":22,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0001525","count":26},{"id":"GO:0015966","count":26},{"id":"GO:0000320","count":25},{"id":"GO:0014850","count":25},{"id":"GO:0006351","count":25}]},{"hash":"2016164042532490470","title":"Rho GTPase\u2013driven actin remodeling and cell migration","description":"This cluster is strongly enriched for actin cytoskeleton dynamics and motility terms: microspike, lamellipodium, and filopodium assembly; regulation of Rho GTPase signaling and associated tyrosine phosphorylation; and positive regulation of cell spreading and adhesion. While a term like uterus development is less directly connected, the prevailing pattern points to actin-driven protrusions, adhesion, and migration processes across the proteins.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0030035","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0050731","count":3},{"id":"GO:0035023","count":3}]},{"hash":"433910704604256681","title":"Neuronal development and signaling","description":"This cluster is enriched for GO terms related to neuron development and neuronal signaling, including axon guidance (semaphorin-plexin), axonal fasciculation, smoothened signaling, and clustering of voltage-gated potassium channels. These indicate a shared role in neural connectivity and excitability. Other terms (bone ossification, spermatid development, thyroid hormone response, mast cell chemotaxis) are present but less central, suggesting additional, broader roles for a subset of proteins. Overall, the core theme is neural development and signaling.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0045163","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0007286","count":2}]},{"hash":"299853449148637815","title":"Growth signaling and cell proliferation","description":"This cluster shows strong enrichment for cell proliferation and division terms (cell population proliferation, cell division, septum digestion after cytokinesis) along with growth-related signaling (response to growth hormone, positive regulation of GTPase activity) and transcriptional control (DNA-templated transcription, positive regulation of transcription by transcription factor localization). The presence of retina development is indicative of a developmental signaling context, but the dominant pattern is growth factor\u2013responsive regulation of proliferation via transcriptional programs.","confidence":"Medium","size":26,"edges":44,"triangles":23,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0008283","count":14},{"id":"GO:0043547","count":14},{"id":"GO:0007568","count":12},{"id":"GO:0060041","count":12},{"id":"GO:0071560","count":12}]},{"hash":"65363039204745536","title":"Developmental Regulation and Growth Signaling","description":"Based on the top GO terms, the proteins are enriched for multicellular organism development and brain development, alongside transcriptional regulation and response to growth signals, suggesting a cluster involved in developmentally regulated gene expression and growth signaling pathways. The presence of DNA-templated transcription and regulation of transcription by transcription factor localization supports a transcription regulatory role during development, while growth hormone response and apoptotic signaling indicate regulation of cell fate during development or stress. The spindle orientation term hints at cell division coordination within development. Overall, the label Developmental Regulation and Growth Signaling captures the main themes.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000132","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0060416","count":1}]},{"hash":"1681690594640400998","title":"Unknown","description":"The GO terms in this cluster are highly diverse, including oxidative-reductive processes (some obsolete), metal ion response, detoxification, and a mix of unrelated biological processes such as neuron migration, muscle cell migration, keratinocyte differentiation, platelet aggregation, grooming behavior, and TNF response. There is no clear, singular theme tying all proteins together, so a coherent functional label cannot be assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:1902987","count":5},{"id":"GO:0010042","count":5},{"id":"GO:0097477","count":5},{"id":"GO:0014909","count":5}]},{"hash":"1680063032693784272","title":"Cellular Regulation and Development","description":"The cluster shows a mix of regulatory functions, including transcription control, protein autophosphorylation, ubiquitination, GTPase signaling, actin cytoskeleton regulation (Arp2/3), and stress responses, with additional developmental annotations (neural tube closure, male gonad development). This diversity suggests a broad regulatory role rather than a single specific pathway, possibly spanning general cellular regulation and developmental processes.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034316","count":9},{"id":"GO:0043547","count":9},{"id":"GO:0006351","count":8},{"id":"GO:0031954","count":8},{"id":"GO:0001843","count":8}]},{"hash":"1225685690917357489","title":"Cell Cycle Regulation and Development Signaling","description":"The cluster is enriched for mitotic cell cycle control and positive regulation of proliferation, along with kinase-related signaling (autophosphorylation and serine/threonine kinase activity) and developmental processes (skin and multicellular organism development). The presence of hypoxia response and RNA processing terms (mRNA transport and spliceosome splicing) suggests these proteins participate in coordinated regulation of cell growth, signaling, and development, rather than a single isolated pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":11},{"id":"GO:0008284","count":10},{"id":"GO:0031954","count":10},{"id":"GO:0043547","count":10},{"id":"GO:0071456","count":10}]},{"hash":"693111484183516162","title":"Ubiquitin-Dependent Protein Degradation and NF-kB Regulation","description":"This cluster is dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, ERAD, different ubiquitin linkages (K6, K63), and autoubiquitination, along with regulation of NF-kappaB signaling and apoptosis. These collectively point to a core function in tagging proteins for degradation and modulating NF-kB pathways, with a few peripheral terms like histone turnover and dosage compensation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0051092","count":14},{"id":"GO:0030433","count":14},{"id":"GO:0085020","count":14},{"id":"GO:0051865","count":14}]},{"hash":"1762128997418185240","title":"Developmental morphogenesis and signaling","description":"These proteins show enrichment for multiple developmental and signaling-related GO terms (laryinthine layer blood vessel development, male gonad development, multicellular organism development, neural tube closure, chondrocyte differentiation, BMP signaling regulation) with associated apoptosis terms, plus a defense-related term that may reflect pleiotropic roles or shared stress responses. The common theme is involvement in developmental pathways and tissue differentiation, with signaling regulation central to their function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060716","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0002062","count":3}]},{"hash":"410390474836780574","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006284","count":3},{"id":"GO:0009663","count":3},{"id":"GO:2001009","count":3},{"id":"GO:0009831","count":3},{"id":"GO:0090502","count":3}]},{"hash":"144204352569227619","title":"T cell signaling and immune activation","description":"The top GO terms point to immune-related processes, notably T cell regulation (activation, proliferation, AICD) and STAT signaling, with parallel hints of receptor endocytosis and cytoskeletal dynamics (lamellipodium assembly, intracellular transport). This pattern suggests a cluster of proteins involved in immune signaling and T cell function, including trafficking and activation pathways. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0046642","count":3},{"id":"GO:0048260","count":3},{"id":"GO:0035023","count":3}]},{"hash":"783878908938689092","title":"Developmental transcriptional regulation","description":"The terms point to gene expression control during development across diverse tissues (hair follicle morphogenesis, roof of mouth, pancreas, cerebellar neural progenitors) and include DNA-templated transcription, with some SMAD signaling regulation terms. This suggests a cohesive theme of developmental gene expression programs.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0031133","count":3},{"id":"GO:0031069","count":3},{"id":"GO:0021930","count":3},{"id":"GO:0060020","count":3}]},{"hash":"1667231847571308974","title":"Neuronal synapse development and signaling","description":"The top GO terms are strongly centered on neuronal development and synaptic function\u2014dendrite development, protein localization to synapse, and long-term synaptic depression\u2014with supporting terms like sensory perception of sound, indicating a focus on neurons and synaptic communication. Some non-neuronal terms appear but the dominant signal points to a neuron/synapse\u2013related cluster.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016358","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0007605","count":3},{"id":"GO:2000670","count":3},{"id":"GO:0060292","count":3}]},{"hash":"1177255251450367613","title":"Mitochondrial ribosome assembly and cristae formation","description":"The top GO terms are dominated by mitochondrial processes: mitochondrial ribosome assembly and cristae formation, pointing to roles in mitochondrial biogenesis and function. Other terms touch on metabolism and broader defense-related pathways, but the strongest signals center on mitochondria, supporting a label focused on mitochondrial structure and translation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001246","count":2},{"id":"GO:0042407","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0061668","count":2},{"id":"GO:0006067","count":2}]},{"hash":"531869832770153886","title":"Placental and Embryonic Development","description":"Most top GO terms describe placental and embryonic development (placental differentiation, trophoblast/giant cell differentiation, pattern formation, endocrine development, EMT in heart cushions, pancreatic development). A few terms are general RNA processing or ribosome export, which are less specific to the cluster\u2019s theme. Overall, the dominant pattern ties to embryogenesis and placental morphogenesis, supporting a cohesive functional label.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":25},{"id":"GO:0060536","count":25},{"id":"GO:0060707","count":25},{"id":"GO:0060972","count":25},{"id":"GO:0035270","count":25}]},{"hash":"328133062266823745","title":"Cell cycle and cell death regulation","description":"The cluster contains proteins associated with both programmed cell death (apoptosis and necroptosis) and cell division processes (mitotic and meiotic), plus regulatory layers such as transcription and signaling/ubiquitination. This suggests a shared theme of controlling cell fate through balancing division and death, with supporting roles in signaling pathways.","confidence":"Medium","size":25,"edges":8,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0070266","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0061178","count":3}]},{"hash":"1499871692101691889","title":"Mitotic cell cycle progression and transcription regulation","description":"This cluster centers on mitotic entry, progression through S and G2/M transitions, and overall cell division, with additional signals of transcriptional control (DNA-templated transcription and RNA Pol II regulation), suggesting a cohesive mitosis- and transcription-focused protein set.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0010696","count":10},{"id":"GO:0000320","count":10},{"id":"GO:0000082","count":10},{"id":"GO:0033598","count":10}]},{"hash":"1479029270982996348","title":"Neural ion transport and GABA signaling in circadian behavior","description":"The cluster is dominated by terms for ion transmembrane transport (sodium, potassium, calcium), GABA signaling, and synaptic activity (excitatory postsynaptic potential), with behavioral and circadian themes (startle response, locomotory behavior, sleep regulation). This points to a cohesive neural signaling module linked to circadian-regulated behaviors.","confidence":"High","size":25,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":20},{"id":"GO:0045188","count":19},{"id":"GO:0001964","count":19},{"id":"GO:0098703","count":19},{"id":"GO:0001661","count":17}]},{"hash":"997932338359080861","title":"Neural development and myelination","description":"The top GO terms are strongly focused on nervous system development, synapse assembly, corpus callosum development, and myelination, indicating a cohesive theme of neural maturation and connectivity. While there are immune-related terms present, the dominant signal points to neural development and myelination as the cluster\u2019s core function. ","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051965","count":16},{"id":"GO:0007399","count":15},{"id":"GO:0007507","count":15},{"id":"GO:0045087","count":15},{"id":"GO:0097350","count":14}]},{"hash":"1086232302575785172","title":"Chromatin remodeling and heterochromatin formation","description":"The cluster is enriched for chromatin-related processes\u2014DNA replication\u2013dependent chromatin assembly, transcription initiation\u2013coupled remodeling, and heterochromatin formation including dosage compensation\u2014suggesting a core role in chromatin organization and transcription regulation.","confidence":"High","size":25,"edges":262,"triangles":1584,"max_degree":24,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0051290","count":18},{"id":"GO:0000122","count":17},{"id":"GO:0006335","count":14},{"id":"GO:0045815","count":14},{"id":"GO:0000183","count":14}]},{"hash":"2055729285750927199","title":"Neural development and synapse formation","description":"The cluster is enriched for terms related to nervous system development, CNS development, axonal fasciculation, synapse assembly, and neural morphogenesis, suggesting a cohesive function in neural wiring and maturation. The ossification and ubiquitination terms may reflect broader developmental processes or protein turnover present in the set.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000172","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0007417","count":3}]},{"hash":"2296675026517718104","title":"DNA replication and repair cluster","description":"The top GO terms are dominated by DNA-templated replication, nucleotide-excision repair, and error-prone translesion synthesis, with a UV-C response signal, pointing to genome maintenance and damage-tolerance functions as the cluster\u2019s core theme; additional terms like muscle development regulation and deubiquitination appear peripheral or incidental.","confidence":"Medium","size":25,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006261","count":4},{"id":"GO:0008033","count":3},{"id":"GO:0006297","count":3},{"id":"GO:0048642","count":3},{"id":"GO:1900037","count":3}]},{"hash":"276161902245596394","title":"Prostaglandin Synthesis and Xenobiotic Detoxification","description":"This cluster centers on prostaglandin biosynthesis and several xenobiotic/alkaloid/dioxin catabolic processes, plus fatty acid omega-oxidation, pointing to a theme of lipid mediator production linked with detoxification pathways. While there are tissue-specific terms (mammary gland development, hepatocyte differentiation) and general stress responses (response to nematode/ozone), the strongest common function appears to be lipid signaling via prostaglandin synthesis coupled with xenobiotic metabolism, suggesting a liver- or barrier-associated module that coordinates signaling and detoxification.","confidence":"Medium","size":25,"edges":42,"triangles":27,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":20},{"id":"GO:0042738","count":19},{"id":"GO:0009822","count":19},{"id":"GO:0030879","count":19},{"id":"GO:0019341","count":19}]},{"hash":"1027954716235090945","title":"Vertebrate Developmental Signaling and Cell Adhesion","description":"This cluster centers on vertebrate development and cellular interactions, with strong signals for nervous system development, bone maturation, and broader multicellular development, plus both homophilic and heterophilic cell adhesion and associated signaling (STAT phosphorylation, NF-kB), and even immunoglobulin production, suggesting a cohesive theme of developmental processes governed by cell\u2013cell communication.","confidence":"Medium","size":25,"edges":71,"triangles":23,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":12},{"id":"GO:0051965","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0007156","count":11},{"id":"GO:0007275","count":11}]},{"hash":"819109569991327693","title":"Developmental Signaling and Proliferation","description":"Based on the GO terms, this cluster centers on signaling pathways that regulate cell growth and development, including DNA replication and cyclin-dependent kinase regulation (cell cycle), VEGF/PDGFR-related proliferation, and angiogenesis. It also includes developmental processes (roof of mouth, hippocampus) and immune signaling components (Fc receptor signaling, STAT phosphorylation), suggesting a broader theme of growth and differentiation signaling across tissues rather than a single precise function.","confidence":"Medium","size":25,"edges":23,"triangles":0,"max_degree":23,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0038091","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0097350","count":2},{"id":"GO:0045736","count":2}]},{"hash":"2155496777763374632","title":"Protein Regulation and Trafficking in Development","description":"The cluster includes terms tied to protein processing and quality control (sumoylation, ubiquitin-dependent ERAD) and intracellular trafficking (Golgi organization), plus signaling and morphogenesis roles (regulation of NFAT signaling, angiogenesis, dendrite morphogenesis, substantia nigra development). This suggests proteins involved in regulating protein modification and trafficking that can influence developmental signaling pathways and morphogenesis. Confidence: Medium","confidence":"","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050774","count":5},{"id":"GO:0030433","count":3},{"id":"GO:0016925","count":3},{"id":"GO:0030437","count":3},{"id":"GO:0007030","count":3}]},{"hash":"1670538814965683727","title":"Transcription and ribosome biogenesis during development","description":"The cluster is dominated by GO terms for DNA-templated transcription, transcription regulation, ribosome biogenesis, and rRNA processing, with development-related terms like multicellular organism development and neural tube closure. This points to a group of proteins linked to gene expression machinery and ribosome assembly that function during developmental processes, with some notes on cell cycle and stress responses.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0007275","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0000463","count":6},{"id":"GO:0006397","count":5}]},{"hash":"2173356267374544414","title":"Diverse Metabolism: Biosynthesis and Catabolism","description":"The top GO terms include both biosynthetic processes (antibiotic biosynthesis, biotin biosynthesis) and a range of catabolic pathways (3-phenylpropionate, stilbene, beta-ketoadipate, uracil, glucuronoside, triglyceride, prostaglandin catabolism), plus nitrogen utilization. This points to proteins involved in broad metabolic functions rather than a single, tight pathway, spanning diverse substrates from aromatics to lipids. Confidence in this broad thematic label is Medium.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":10},{"id":"GO:0009102","count":9},{"id":"GO:0019380","count":7},{"id":"GO:0019740","count":7},{"id":"GO:0046272","count":7}]},{"hash":"1102281201382761473","title":"Epigenetic Regulation in Development","description":"The top terms center on RNA guanine-N7 methylation and several histone methylations, plus DNA-templated transcription, pointing to chromatin modification and transcriptional control. The presence of brain development and multicellular organism growth further supports a developmental regulatory role. Together, these suggest proteins in this cluster modulate gene expression via epigenetic marks during development, with related nutrient-growth signaling and cellular transport processes connected but not overriding this theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0034729","count":3},{"id":"GO:0051568","count":3},{"id":"GO:0007420","count":3}]},{"hash":"1688481435904119986","title":"Cell Cycle and Signaling Pathways","description":"The top GO terms center on core cell division (mitotic cell cycle, DNA replication) while many terms point to diverse signaling pathways (T cell receptor, ephrin receptor, Wnt, MAPKK, serine/threonine kinase signaling). Development-related terms like angiogenesis and hippocampus development suggest these proteins coordinate proliferation with multiple signaling networks in growth and differentiation. This points to a cluster of proteins involved in cell-cycle control intertwined with broad signaling pathways.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":23},{"id":"GO:0006260","count":22},{"id":"GO:0033138","count":21},{"id":"GO:0050852","count":21},{"id":"GO:0048013","count":20}]},{"hash":"955717301271412172","title":"Folate and one-carbon metabolism","description":"Top GO terms are dominated by formate metabolism and folate-related processes (folic acid biosynthesis, folate catabolism, tetrahydrofolate interconversion), pointing to folate and one-carbon metabolism as the core function of this cluster. The other terms (RNA processing, translation initiation, prostaglandin response) may reflect secondary roles or annotation noise, but do not override the folate-centric signal.","confidence":"Medium","size":25,"edges":15,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0015942","count":3},{"id":"GO:0009396","count":3},{"id":"GO:0046657","count":3},{"id":"GO:0035999","count":3},{"id":"GO:1901407","count":3}]},{"hash":"884369757876073970","title":"Transcriptional Regulation in Development","description":"The cluster centers on GO terms for regulation of DNA-templated transcription and transcription initiation, with signals of chromatin regulation, and estrogen receptor pathway control, suggesting core transcriptional regulators. Developmental terms (heart development, branching morphogenesis) and cell migration/immune-related terms imply these regulators influence differentiation and tissue morphogenesis, with downstream immune and cytoskeletal processes. Overall, it appears to group proteins that regulate gene expression during development, with ancillary roles in signaling and immune interactions.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0016477","count":2},{"id":"GO:0033146","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0006909","count":2}]},{"hash":"1594914767376999652","title":"Embryonic Morphogenesis and Organ Development","description":"The top GO terms converge on developmental and morphogenetic processes across multiple tissues (palate, cartilage, hair follicles, pancreas, endocardial cushion, placenta) and include related cellular events like epithelial-to-mesenchymal transition and general multicellular development, with supporting gene-regulation processes (transcriptional regulation, splicing). This suggests a developmental/morphogenetic program rather than a single pathway, hence the label. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0007275","count":3},{"id":"GO:1903026","count":3},{"id":"GO:0031069","count":3},{"id":"GO:0000398","count":3}]},{"hash":"754165519363584261","title":"Embryonic development and morphogenesis","description":"The GO terms are dominated by embryonic development and tissue morphogenesis, including placenta/trophoblast differentiation, heart/endocardial cushion formation, cartilage morphogenesis, and left-right patterning, indicating a cluster centered on developmental organogenesis; a minority term on innate immunity and transcriptional regulation does not override this theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0035270","count":4}]},{"hash":"932176082177405611","title":"Neurodevelopment and Synaptic Plasticity","description":"The top terms cluster around brain development, substantia nigra development, and long-term synaptic potentiation, pointing to neural development and synaptic function. Supporting terms like cell migration and regulation of GTPase activity align with developmental signaling and cytoskeletal dynamics. Some bone and heart development terms are present but do not dominate, suggesting a primarily neural development-focused cluster with related developmental processes.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0043931","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0006915","count":2}]},{"hash":"2083649923606784942","title":"Cell Cycle Regulation and Differentiation","description":"This set shows links between cell-cycle control (CDK inhibition, centrosome cycle), telomere maintenance, and tissue differentiation (fat cell and cerebellar granule neuron differentiation), along with supporting processes like mRNA processing and cell migration, pointing to a broad theme of growth, division, and lineage specification rather than a single pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":5},{"id":"GO:0006397","count":5},{"id":"GO:0035994","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0032212","count":5}]},{"hash":"232811189356970800","title":"Neural development and cell cycle regulation","description":"The cluster features strong signals for mitotic cell cycle and DNA replication, indicating proliferation-related proteins, alongside neural development cues like dendrite morphogenesis, nervous system and hippocampus development, axon extension and signaling (JNK, focal adhesion, phosphorylation). This suggests a group of proteins involved in neural progenitor proliferation and subsequent neuronal differentiation and axon growth, i.e., neural development with cell cycle control.","confidence":"Medium","size":25,"edges":5,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":23},{"id":"GO:0006260","count":20},{"id":"GO:0048813","count":20},{"id":"GO:0007399","count":20},{"id":"GO:0021766","count":19}]},{"hash":"970426862081238682","title":"Unknown","description":"GO terms span immune (complement activation), neural (synaptic potentiation, axonal transport), skin/hair (keratinocyte activation, hair follicle morphogenesis, skin barrier), lens development, and heart development, with no single shared function tying the proteins; the lack of edges and diverse terms suggest no cohesive theme, so a neutral Unknown label is appropriate.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0060291","count":1},{"id":"GO:0043000","count":1},{"id":"GO:0033693","count":1},{"id":"GO:0061436","count":1}]},{"hash":"1895311613673150765","title":"Cell growth and vesicle trafficking","description":"The cluster centers on core growth-related processes: cell division and mitotic cycle, ribosome biogenesis for protein synthesis, and vesicle transport between the ER and Golgi (including retrograde transport), all of which support cellular expansion and proliferation. Additional terms like pigmentation, maintenance of cell polarity, and neuron projection development are linked to vesicle trafficking and polarity in specialized cells, reinforcing a unifying theme of growth-associated cellular machinery and intracellular transport.","confidence":"High","size":25,"edges":52,"triangles":31,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0031175","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0000747","count":7}]},{"hash":"5161194871059653","title":"Neurodevelopment and Innate Immune Signaling","description":"This cluster is dominated by terms tied to neural and brain development (multicellular organism development, neural tube closure, brain development, nervous system development) while also featuring innate immune and signaling terms (innate immune response, defense against Gram-positive bacteria, immunoglobulin production, ERK cascade, NF-kappaB-related activity). The co-occurrence suggests proteins that participate in neural development with concurrent roles in immune signaling or cross-talk between development and immune pathways. Confidence: Medium","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0001843","count":6},{"id":"GO:0051092","count":6},{"id":"GO:0007420","count":5},{"id":"GO:0002377","count":5}]},{"hash":"364452476216652197","title":"Embryonic Development and Tissue Morphogenesis","description":"This cluster centers on developmental patterning and morphogenesis, with GO terms spanning left/right pattern formation, placenta and endocrine system development, cartilage morphogenesis, EMT in heart cushion formation, palatal development, and pancreatic cell development, plus transcriptional regulation. This suggests proteins involved in embryogenesis and the shaping of tissues and organs.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0060806","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6}]},{"hash":"2055312623647757130","title":"Embryonic morphogenesis and organ development","description":"The terms are all related to development and morphogenesis across multiple embryonic tissues (hair follicles, cartilage, palate, mesoderm, placenta, heart cushion EMT, trophoblast, left-right patterning, endocrine development). This suggests a cohesive theme of embryonic organogenesis and tissue formation, supporting a label centered on developmental morphogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0007498","count":5},{"id":"GO:0060806","count":4}]},{"hash":"2085429200173409288","title":"Rho/Ras GTPase Signaling and Synaptic Regulation","description":"This cluster is dominated by GO terms for regulation of Rho and Ras GTPase signaling, positive regulation of GTPase activity, and synaptic-related processes (long-term potentiation, synapse assembly), with supporting lipid signaling (inositol trisphosphate biosynthesis, phospholipid catabolic process). The pattern suggests a cohesive module centered on GTPase-driven signal transduction that links cytoskeletal dynamics with neuronal communication, while also touching on broader immune/vascular signaling contexts.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":9},{"id":"GO:0046580","count":7},{"id":"GO:0043314","count":6},{"id":"GO:0060313","count":6},{"id":"GO:0043547","count":6}]},{"hash":"1177305072164854943","title":"Cytokine-driven inflammatory response and granulocyte recruitment","description":"Given the enrichment for defense against fungus and multiple GO terms describing positive regulation of cytokine and interleukin production (IL-5, IL-13, IL-23) and granulocyte chemotaxis, the proteins appear to function in innate immune signaling and inflammatory responses. The presence of fibroblast activation and ER-to-Golgi transport suggests tissue remodeling and secretory activity common in inflammation. While a few terms hint at brain development or nutrient response, the dominant pattern is cytokine-mediated immune signaling and granulocyte recruitment.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050832","count":2},{"id":"GO:1900017","count":2},{"id":"GO:2000667","count":2},{"id":"GO:0032747","count":2},{"id":"GO:2000664","count":2}]},{"hash":"687962427827540190","title":"ECM Remodeling and Basement Membrane Dynamics","description":"The top GO terms cluster around collagen catabolism, collagen-activated signaling, integrin biosynthesis, and processes related to the glomerular basement membrane and extracellular matrix organization. This points to extracellular matrix turnover, basement membrane formation/remodeling, and associated cell adhesion pathways, with some involvement of coagulation and complement components. Overall, a cohesive theme of ECM remodeling with basement membrane dynamics.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030574","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0038063","count":3}]},{"hash":"1539536900215042613","title":"Innate Immune Signaling and Bacterial Defense","description":"The top GO terms are dominated by innate immunity and bacterial defense processes (innate immune response, defense against bacterium, cellular response to peptidoglycan, chemokine production), with signaling pathways like ERK and NF-kappaB also appearing, indicating inflammatory signaling. Some outliers relate to immunoglobulin production, GI epithelium maintenance, and nervous system development, but the core cluster centers on innate immune activation and antimicrobial responses.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0042742","count":3},{"id":"GO:0035234","count":3}]},{"hash":"1069036910839022585","title":"Cell cycle, transcription, and survival signaling","description":"The set is enriched for core processes in gene expression (DNA-templated transcription, translation) and cell division (mitotic cell cycle, chromosome segregation), with concurrent regulatory signaling (Wnt, NF-kappaB) and apoptosis. This pattern suggests a cluster of proteins involved in coordinating cell growth, division, and survival signaling, rather than a single pathway, hence the chosen label.","confidence":"Medium","size":24,"edges":6,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0006412","count":3}]},{"hash":"368765684184377888","title":"Embryonic and Organ Morphogenesis","description":"The top GO terms are all developmental in nature, covering morphogenesis of forebrain, pituitary, pharyngeal system, digits, gonads, digestive tract, and other tissues, indicating a broad theme of embryonic organ development rather than a single pathway.","confidence":"High","size":24,"edges":32,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0045600","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0071542","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0048565","count":3}]},{"hash":"543330998941091263","title":"Axonogenesis and immune/angiogenesis regulation","description":"This cluster features strong signals for neural development (axonogenesis, axonal fasciculation) alongside terms related to innate immunity (innate immune response, defense against Gram-positive bacteria) and regulation of angiogenesis and bone development. The combination suggests proteins involved in neural development with modulatory roles in vascular and immune signaling, hence a label that highlights axonogenesis plus immune/angiogenesis regulation. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006469","count":17},{"id":"GO:0007409","count":15},{"id":"GO:0019800","count":15},{"id":"GO:0007413","count":15},{"id":"GO:0060348","count":15}]},{"hash":"1299532468775548239","title":"Peroxisomal fatty acid oxidation and lipid metabolism","description":"The cluster is strongly enriched for peroxisome-related and lipid-energy terms: glyoxysome organization, fatty acid beta-oxidation, acetyl-CoA catabolic process, and ketone body biosynthetic process, plus liver/adipose development and response to starvation. This points to a cohesive role in peroxisomal lipid breakdown and energy production, especially under nutrient scarcity, with supporting terms like lipid transport and protein oligomerization.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":9},{"id":"GO:0042594","count":9},{"id":"GO:0046951","count":8},{"id":"GO:0006635","count":7},{"id":"GO:0019619","count":6}]},{"hash":"1605124435122201911","title":"Cell signaling and proliferation","description":"These proteins show enrichment in signaling pathways (Wnt, T cell receptor), regulators of growth and division (mitotic cell cycle, DNA replication, transcription), and developmental/motile processes (dendrite morphogenesis, chemotaxis). While potassium transport is a broader cellular function present, the common thread is coordination of signaling with cell growth and division. ","confidence":"Medium","size":24,"edges":8,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006813","count":12},{"id":"GO:0090263","count":10},{"id":"GO:0043552","count":10},{"id":"GO:0000278","count":10},{"id":"GO:0048813","count":10}]},{"hash":"2157991395145243941","title":"Embryonic skeletal development and ECM remodeling","description":"The cluster is strongly linked to embryonic development and skeletal formation, with terms like skeletal system development, embryonic skeletal system morphogenesis, collagen fibril organization, and in utero embryonic development. Notch signaling and proteolysis further support developmental and extracellular matrix remodeling roles, while other terms appear as noise. Thus, a label focusing on embryonic skeletal development and ECM remodeling best captures the core theme.","confidence":"Medium","size":24,"edges":23,"triangles":0,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0090200","count":3},{"id":"GO:0006958","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0048070","count":2},{"id":"GO:0006508","count":2}]},{"hash":"2128503685357971400","title":"Neural development and sensory organ formation","description":"This cluster centers on nervous system development (brain development, corticospinal tract morphogenesis), sensory perception of sound, and synapse assembly, with additional hints of epithelial polarity (apical protein localization, planar polarity) and keratinization. The combination suggests neuroepithelial differentiation and morphogenesis relevant to neural and sensory tissues, rather than a single metabolic or structural pathway.","confidence":"Medium","size":24,"edges":6,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043931","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0031424","count":4},{"id":"GO:0021957","count":4},{"id":"GO:0045176","count":4}]},{"hash":"1561414316102535677","title":"Neural Sensory Perception and GPCR-cGMP Signaling","description":"The top terms cluster around neural sensory functions (pain perception, visual perception, temperature response) and neuromodulatory signaling (GABAergic synaptic transmission, GPCR signaling linked to cGMP, prostaglandin response, and cocaine-related behaviors). The combination suggests a cohesive theme of neuronal sensory processing and GPCR-mediated signaling pathways that regulate excitability and synaptic transmission. A heart development term is present but appears less central to the core neural signaling theme; overall, the label reflects the dominant function of sensory perception and GPCR-driven neuronal signaling in the cluster.","confidence":"High","size":24,"edges":52,"triangles":10,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":24},{"id":"GO:0007601","count":23},{"id":"GO:0002024","count":23},{"id":"GO:0071502","count":23},{"id":"GO:0048148","count":22}]},{"hash":"1703614209962572856","title":"Developmental signaling and organogenesis","description":"This cluster is characterized by multiple tissue-development terms (Notch signaling, glial fate commitment, neural retina and bronchiole development, nephron tubule morphogenesis) alongside broader transcription (RNA polymerase II) and regulatory responses (xenobiotic response, heart rate regulation). The common theme appears to be developmental signaling guiding organogenesis and cell fate decisions across diverse tissues, with transcriptional regulation underpinning these processes.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":21},{"id":"GO:0048712","count":19},{"id":"GO:2001038","count":19},{"id":"GO:0007219","count":18},{"id":"GO:0072282","count":18}]},{"hash":"1465276428247168296","title":"Neural signaling and sensory perception","description":"The top GO terms cluster around nervous system functions: sensory perception (pain, vision), dopaminergic synaptic transmission, and behavioral responses to drugs like cocaine. ERK signaling and responses to prostaglandin also point to neuronal signaling regulation, with some developmental terms (multicellular organism and heart development) suggesting broader roles but the dominant pattern is neural signaling and sensory processing.","confidence":"Medium","size":24,"edges":80,"triangles":99,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0007275","count":9},{"id":"GO:0070374","count":8},{"id":"GO:0071333","count":8},{"id":"GO:0043330","count":8}]},{"hash":"2123413183524369897","title":"Cardiac ion transport and calcium signaling","description":"Top GO terms indicate a cohesive cardiac-specific module centered on membrane ion transport (sodium export, potassium import), calcium homeostasis, membrane repolarization, and calcium-dependent regulation of cardiac contraction, with some terms relating to heart morphogenesis. This points to a function cluster focused on cardiac ion transport and calcium signaling, explaining the observed enrichment.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0055119","count":4},{"id":"GO:0090662","count":3},{"id":"GO:0036376","count":3},{"id":"GO:0006874","count":3},{"id":"GO:1903288","count":3}]},{"hash":"811791137947466699","title":"Nucleolar ribosome biogenesis and transcription","description":"The set is enriched in GO terms tied to ribosome biogenesis and nucleolar transcription across RNA polymerases I, II, and III (rRNA and tRNA transcription), along with nucleologenesis and RNA-templated transcription, suggesting a core function in nucleolar assembly and ribosome production. A few entries mention regulatory ncRNA\u2013heterochromatin formation and innate immune/antibiotic responses as minor associations, but the dominant signal centers on nucleolar ribosome biogenesis and transcription.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":7},{"id":"GO:0042790","count":3},{"id":"GO:0017126","count":3},{"id":"GO:0042797","count":3},{"id":"GO:0001172","count":3}]},{"hash":"438579495202819768","title":"Wnt\u2013Hippo Signaling and Developmental Differentiation","description":"The top terms point strongly to canonical Wnt signaling and Hippo pathway activity, coupled with developmentally linked processes (paraxial mesoderm development, keratinocyte differentiation) and apoptosis, along with cytoskeletal signaling (Rho, ephrin) and actin remodeling. This suggests a cohesive role in coordinating cell fate decisions and structural changes during development via Wnt/Hippo axis signaling and related pathways.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":17},{"id":"GO:0060044","count":16},{"id":"GO:0035329","count":16},{"id":"GO:0006915","count":16},{"id":"GO:0030216","count":16}]},{"hash":"1343719720121759244","title":"Ubiquitin-Proteasome Regulation of Signaling","description":"The cluster shows strong enrichment for ubiquitination-related processes (deubiquitination, protein sumoylation, SCF-dependent ubiquitin ligase activity) and proteasome-dependent protein catabolic processes, along with regulatory roles in signaling pathways (positive/negative regulation of canonical Wnt signaling and non-canonical NF-kappaB signaling). This suggests a coherent theme: ubiquitin-proteasome\u2013mediated control of protein turnover and signaling pathway modulation. The SRP-dependent targeting term hints at co-translational handling of some components, supporting a broader link to protein quality control and trafficking, but the central link remains ubiquitin-proteasome\u2013driven regulation of signaling. ","confidence":"High","size":24,"edges":139,"triangles":424,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:0090263","count":7},{"id":"GO:0090090","count":6},{"id":"GO:0016925","count":6},{"id":"GO:0038061","count":5}]},{"hash":"633339618389872310","title":"NF-kappaB Signaling Regulators in Development","description":"These proteins collectively point to modulation of NF-kappaB signaling (both canonical and non-canonical) and suppression of TGF-beta/BMP pathways, which are central to development. The presence of nervous system and multicellular development terms, along with endothelial barrier establishment and Golgi/GTPase-related regulation, suggests a coordinated role in developmental signaling and cellular trafficking. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030512","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0007399","count":2}]},{"hash":"2113650528854626382","title":"Mesoderm Formation and Vascular Development","description":"The top GO terms cluster around mesoderm formation, stem cell differentiation, VEGF/PDGF signaling driving proliferation, and ECM remodeling, with supporting notes on muscle activity and cell cycle re-entry. This points to a cohesive developmental program for mesoderm-derived tissues and their vascular/muscular context, rather than a single enzymatic function.","confidence":"Medium","size":24,"edges":255,"triangles":1626,"max_degree":23,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":24},{"id":"GO:0006351","count":24},{"id":"GO:0014850","count":24},{"id":"GO:2000738","count":24},{"id":"GO:0001707","count":24}]},{"hash":"223200296699126431","title":"Embryonic Development and Organ Morphogenesis","description":"This cluster centers on embryogenesis and the formation of various Organs and tissues, with terms covering in utero embryonic development, heart and eye morphogenesis, gonad development, prostate morphogenesis, myoblast proliferation, and neuron maturation, all pointing to coordinated developmental regulation and organ formation.","confidence":"High","size":24,"edges":92,"triangles":60,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0001701","count":11},{"id":"GO:0048048","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0003148","count":11}]},{"hash":"30771395057362340","title":"Developmental organ morphogenesis","description":"The cluster is enriched for terms tied to the morphogenesis and development of various organs (pancreas, eye, heart, gonads, prostate) and general growth, plus DNA-templated transcription, suggesting a broad developmental program governing organ formation and tissue patterning rather than a single tissue-specific function.","confidence":"High","size":24,"edges":8,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0061113","count":9},{"id":"GO:0045872","count":9},{"id":"GO:0035264","count":9},{"id":"GO:0006351","count":8},{"id":"GO:0060527","count":8}]},{"hash":"146955540544317900","title":"Neuronal synaptic vesicle trafficking and lipid homeostasis","description":"The cluster is characterized by terms focused on membrane lipid regulation and synaptic function, including phospholipid homeostasis, regulation of synaptic vesicle exocytosis, and brain development, which together point to neuronal membrane trafficking and lipid homeostasis as the core theme. Some terms (e.g., mating projection growth) are less directly related and may reflect noise or conserved components with broader roles. Overall, the dominant signal supports a neuronal/synaptic function with membrane lipid involvement.","confidence":"High","size":24,"edges":234,"triangles":1306,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":14},{"id":"GO:0010628","count":14},{"id":"GO:2000300","count":12},{"id":"GO:0035900","count":12},{"id":"GO:0007420","count":12}]},{"hash":"1955148207018023498","title":"Embryonic organogenesis and neural development","description":"The top GO terms point to broad embryonic development and organogenesis across multiple tissues (heart, cranial skeleton, neural migration, visual system, organ induction), suggesting these proteins collectively function in early development rather than a single pathway.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":11},{"id":"GO:0061551","count":11},{"id":"GO:0001759","count":10},{"id":"GO:0048701","count":10},{"id":"GO:0003350","count":10}]},{"hash":"215510010105464699","title":"Bacterial fatty acid and lipid biosynthesis","description":"The top GO terms are dominated by fatty acid biosynthetic processes and various fatty-acyl-CoA metabolic steps (e.g., very long-chain and medium-chain), plus lipoteichoic acid and menaquinone biosynthesis, all pointing to lipid production and lipid-associated metabolism in bacteria. Other terms like seed coat development and bioluminescence are sporadic and less coherent with the main theme, but do not override the lipid-centric signal. Overall, this cluster appears to unite enzymes involved in lipid biosynthesis and related metabolite production. ","confidence":"High","size":24,"edges":132,"triangles":394,"max_degree":19,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006633","count":14},{"id":"GO:0019654","count":11},{"id":"GO:0000038","count":11},{"id":"GO:0070395","count":11},{"id":"GO:0010214","count":11}]},{"hash":"176292736312944875","title":"Neural development and synaptic morphogenesis","description":"The cluster is enriched for GO terms tied to nervous system development, axon guidance/fasciculation, dendritic spine morphogenesis, and synaptic regulation (including long-term synaptic depression and sympathetic nervous system development), suggesting a cohesive role in neural connectivity and synaptic organization.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":4},{"id":"GO:0060292","count":3},{"id":"GO:0048320","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0043507","count":3}]},{"hash":"1481376397129102600","title":"Neural crest migration and axon guidance","description":"This cluster centers on nervous system development with emphasis on neural crest cell migration and axon pathfinding, highlighted by terms like trigeminal nerve organization, branchiomotor neuron axon guidance, semaphorin-plexin signaling, and general nervous system development. The inclusion of homophilic/heterophilic cell adhesion supports tissue organization during these processes, making this label representative of the dominant theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":10},{"id":"GO:0007157","count":10},{"id":"GO:1902287","count":8},{"id":"GO:0045663","count":8},{"id":"GO:0007399","count":8}]},{"hash":"1136986748838474106","title":"Unknown","description":"The top GO terms span neural sensing, cell junctions, immune activation, vascular regulation, development, post-translational modification, and metabolism, with no clear, cohesive function tying the majority of proteins together. This heterogeneity suggests no single interpretable label.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0090118","count":2},{"id":"GO:0021517","count":2}]},{"hash":"1267195075969283767","title":"Developmental signaling and trafficking","description":"These proteins appear tied to signaling pathways (TORC1, Wnt) that govern development and tissue formation (mesoderm and skeletal development, muscle growth regulation). They also cluster around vesicle trafficking and endocytosis (synaptic vesicle coating, clathrin-dependent endocytosis, intracellular transport), which are often linked to signaling modulation. Additionally, cell adhesion and immune-related terms (heterotypic cell-cell adhesion, monocyte aggregation) suggest roles in coordinating cell interactions during development. Altogether, the set points to a theme of signaling and trafficking processes that drive development and tissue organization rather than a single narrowly defined function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038202","count":2},{"id":"GO:0016183","count":2},{"id":"GO:0072583","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0016055","count":2}]},{"hash":"635591379669413097","title":"Unknown","description":"The top GO terms are highly diverse, covering ubiquitination, various developmental processes (trophoblast giant cell differentiation, cardiac conduction system development), sensory perception, cell division, immune tolerance regulation, plant cutin/suberin biosynthesis, and symbiont-host interactions. There is no single, cohesive function or pathway that ties these terms together for this protein set, suggesting either a broad, non-specific annotation mix or cross-kingdom noise. Therefore, a concise, representative label cannot be assigned.","confidence":"","size":24,"edges":39,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":4},{"id":"GO:0060707","count":3},{"id":"GO:0003161","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0051301","count":3}]},{"hash":"838916153533061197","title":"Spliceosome-regulated mRNA splicing and processing","description":"Cluster shows strong enrichment for spliceosome-mediated regulation of mRNA splicing (positive/negative/alternative), mRNA stability, and mRNA export, with additional related translation initiation terms. This cohesive pattern points to a module of RNA processing regulators centered on the spliceosome and mRNA maturation pathways.","confidence":"High","size":24,"edges":247,"triangles":1477,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":15},{"id":"GO:1901407","count":14},{"id":"GO:0000381","count":14},{"id":"GO:0075525","count":13},{"id":"GO:0048025","count":13}]},{"hash":"74669167691457448","title":"Developmental transcription regulation","description":"The cluster features direct terms for RNA polymerase II\u2013mediated transcription and its negative regulation, alongside numerous organ development terms (pancreas, kidney/ureteric bud morphogenesis, uterus, pituitary, retina, habenula, cranial skeleton). This suggests a common theme of transcriptional control guiding diverse developmental processes.","confidence":"High","size":24,"edges":154,"triangles":333,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0000122","count":10},{"id":"GO:0090190","count":10},{"id":"GO:0031018","count":10},{"id":"GO:0060065","count":9}]},{"hash":"439719367870430195","title":"Neural Development and Gene Expression Regulation","description":"Top GO terms indicate a blend of neural development processes (neural tube formation, glutamatergic synaptic transmission), structural/ciliary organization (cilium assembly), and core gene expression activities (mRNA splicing via spliceosome, DNA-templated transcription, DNA integration), plus extracellular matrix biosynthesis (heparin proteoglycan biosynthetic process) and survival signaling (negative regulation of apoptotic pathways). Together, these point to a cluster of proteins involved in developmental gene regulation with a neural development emphasis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:1902042","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0051968","count":2}]},{"hash":"58517297725080507","title":"RNA Pol II Transcription Regulation","description":"Most frequent terms point to transcription by RNA polymerase II and its regulation, including DNA-templated transcription and negative regulation of RNAP II activity, suggesting the cluster primarily comprises factors involved in gene-expression control. Additional terms hint at RNA processing and regulation under cellular stress (redox homeostasis, detoxification) and one odd viral process term, which may reflect annotation artifacts or broad regulatory connections rather than a cohesive, distinct function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0071039","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0045454","count":2}]},{"hash":"845816700651181389","title":"Immune Cell Adhesion and Signaling","description":"The term set centers on cell-cell adhesion (homophilic/heterophilic), immune receptor signaling (B cell receptor pathway), and regulatory effects on cytotoxic lymphocytes and macrophages, all of which point to immune cell interactions and activation control, including actin remodeling linked to immune synapse formation. Some terms may be less directly connected (symbiont entry, AV node adhesion), but the overall theme is immune adhesion and signaling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043031","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0090138","count":3},{"id":"GO:0002859","count":3},{"id":"GO:0007157","count":3}]},{"hash":"1212426958086780554","title":"Pain and Temperature Sensory Signaling","description":"The top GO terms cluster around pain perception, temperature stimulus response, and neuronal action potentials, pointing to a theme of sensory neuron signaling related to pain and temperature. While a few terms touch on development or immune signaling, the core hints are clearly pain/temperature sensing and neural excitability.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0048265","count":5},{"id":"GO:0034767","count":4}]},{"hash":"663192912706231673","title":"Embryonic development and organ morphogenesis","description":"The GO terms cluster around embryogenesis and organ formation across tissues (heart/endocardial cushion, placenta, cartilage, pancreas, trophoblast, endocrine system, left-right patterning). A few terms concern general transcription/splicing, but the dominant theme is developmental biology. Confidence: High","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":8},{"id":"GO:0060806","count":7},{"id":"GO:0060536","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003323","count":7}]},{"hash":"598290716452554823","title":"Embryonic development and morphogenesis","description":"The terms cluster around embryogenesis and tissue morphogenesis (placenta, mesoderm, cartilage, hair follicle) and left-right patterning, suggesting a cohesive developmental function across embryonic tissues; a few metabolic terms are present but secondary.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":24},{"id":"GO:0060536","count":24},{"id":"GO:0060707","count":24},{"id":"GO:0019430","count":24},{"id":"GO:0034396","count":24}]},{"hash":"2022005883953948390","title":"Ribosome biogenesis and rRNA maturation","description":"This cluster centers on ribosome production and RNA processing, with strong signals for translation, ribosome biogenesis, and maturation of SSU/LSU and 5.8S rRNA from tricistronic transcripts, indicating a core role in ribosome assembly and rRNA maturation; additional terms like mRNA export and transcription reflect broader coordination of gene expression.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":7},{"id":"GO:0000462","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0006406","count":4}]},{"hash":"128168360528485413","title":"Unknown","description":"The top GO terms span a mix of platelet function, hormone signaling, regional development across organisms (forebrain, head, phloem, pancreatic cells), miRNA silencing, and endocytic recycling. This broad spread provides no single cohesive function or pathway linking the proteins, so a generic Unknown label is appropriate.","confidence":"","size":23,"edges":141,"triangles":507,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":11},{"id":"GO:0060396","count":8},{"id":"GO:0021871","count":8},{"id":"GO:0035195","count":8},{"id":"GO:0003324","count":8}]},{"hash":"1045288703157921847","title":"Spliceosome and mRNA Processing Machinery","description":"The cluster is characterized by multiple GO terms centered on mRNA splicing (positive/negative regulation, alternative splicing via spliceosome), spliceosome assembly and processome components, mRNA export and stabilization, and translation initiation steps, indicating a group of proteins involved in RNA maturation and handling before translation.","confidence":"High","size":23,"edges":185,"triangles":935,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0075525","count":3},{"id":"GO:0048025","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0001731","count":3}]},{"hash":"1931067392382972429","title":"Spliceosome Regulation and mRNA Processing","description":"Most terms are about spliceosome-mediated mRNA splicing (positive/negative regulation, alternative splicing, cis splicing) and mRNA export, with a few related to translation initiation and viral reinitiation. This points to proteins involved in RNA processing and regulation of gene expression, centered on the spliceosome.","confidence":"High","size":23,"edges":200,"triangles":1003,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":13},{"id":"GO:0031047","count":13},{"id":"GO:0045292","count":11},{"id":"GO:0075525","count":10},{"id":"GO:0048025","count":10}]},{"hash":"917704383099852787","title":"Spliceosome-Mediated mRNA Processing and Export","description":"This cluster's top GO terms cluster around mRNA maturation\u2014splicing via the spliceosome, splicing regulation, poly(A) processing, and mRNA export from the nucleus\u2014with additional links to ncRNA-mediated gene silencing, indicating a cohesive role in post-transcriptional mRNA processing and trafficking.","confidence":"High","size":23,"edges":13,"triangles":5,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":4},{"id":"GO:0045292","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0016973","count":4},{"id":"GO:0031047","count":4}]},{"hash":"2206149147846052418","title":"Innate Immune Response and Phagolysosome Function","description":"This cluster is enriched for phagolysosome assembly and defense against Gram-positive bacteria, pointing to innate immune activity. The presence of T cell homeostasis and calcium signaling terms suggests linked immune communication and activation pathways. Although a few terms relate to development, the immune-related terms constitute the strongest theme, justifying the label.","confidence":"Medium","size":23,"edges":38,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0001845","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0050909","count":4},{"id":"GO:0043029","count":4}]},{"hash":"2267389590817073765","title":"Cytoskeleton remodeling and cell migration","description":"This cluster centers on actin cytoskeleton dynamics and motility, with strong representation for actin filament bundle assembly, ruffle formation, cell migration, and epithelial cell polarity. Regulatory signals such as Wnt and GPCR pathways provide context for directional movement and cytoskeletal remodeling. A couple of terms (subtelomeric heterochromatin formation, megakaryocyte development) may reflect broader annotations or noise. ","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0035855","count":3}]},{"hash":"732121994444632514","title":"Telomere maintenance and cell cycle control","description":"Protein set shows multiple GO terms centering on telomere maintenance regulation (via telomerase) and telomere length control, plus negative regulation of G1/S transition of the mitotic cell cycle and general cell division, with Wnt signaling also represented. This combination suggests a cluster tied to telomere biology and cell cycle control, possibly with growth-signaling interactions (Wnt). Some terms are obsolete or nonspecific, but the core theme remains telomere maintenance and cell cycle regulation.","confidence":"High","size":23,"edges":30,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:2000134","count":3},{"id":"GO:0051301","count":2},{"id":"GO:1901998","count":2},{"id":"GO:0014823","count":2}]},{"hash":"455457526375816775","title":"Developmental signaling and ECM organization","description":"The top GO terms cluster around embryonic development and tissue morphogenesis, with BMP signaling, endocrine system development, cartilage morphogenesis, and collagen fibril organization, plus cell adhesion. This suggests a cohesive theme of developmental signaling guiding tissue formation and ECM remodeling.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0008101","count":4},{"id":"GO:0051965","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0046326","count":3}]},{"hash":"1052053097696025053","title":"Neural development and chromatin regulation","description":"The cluster is enriched for brain and midbrain development terms and for transcription regulation via chromatin modifications (histone acetylation, RNAP II transcription preinitiation complex assembly). This points to proteins involved in chromatin remodeling and gene expression control during neural development. Some terms like DNA repair and immune responses appear as secondary associations and do not define the core function of the group.","confidence":"Medium","size":23,"edges":8,"triangles":3,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0043966","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0006281","count":6},{"id":"GO:0007549","count":5},{"id":"GO:0000436","count":5}]},{"hash":"428233760065680261","title":"Neurotransmitter transport and glycinergic signaling","description":"The top terms point to neural function, with glycine secretion, glycinergic synaptic regulation, serotonin uptake/secretion, and dopamine catabolism, plus transport of amino acids (proline, leucine). Together these indicate neurotransmitter handling and synaptic regulation in the nervous system, with supporting developmental glial and thalamic context. Confidence: High","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0061537","count":7},{"id":"GO:0042066","count":7},{"id":"GO:0051610","count":7},{"id":"GO:1905847","count":7},{"id":"GO:0015824","count":7}]},{"hash":"2148333068605045164","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"581689733866515093","title":"Ribosome Biogenesis and Translation","description":"The proteins are enriched for translation-related GO terms (translation, cytoplasmic translation) and ribosome biogenesis (including ribosomal subunit biogenesis) as well as tRNA modification and nuclear-export steps for ribosomal subunits, pointing to a cluster of factors involved in ribosome production and protein synthesis. Some cell cycle/division terms suggest coordination between ribosome assembly and cell growth.","confidence":"High","size":23,"edges":10,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":7},{"id":"GO:0002181","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0006400","count":4}]},{"hash":"1934420928846909064","title":"RNA processing and translation initiation","description":"The terms show a strong convergence on mRNA splicing via the spliceosome (including regulation and alternative splicing) and on initiation/reinitiation of translation, suggesting a cluster of factors involved in RNA processing and translation control.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":12},{"id":"GO:0002188","count":12},{"id":"GO:0006378","count":11},{"id":"GO:0045292","count":11},{"id":"GO:1901407","count":10}]},{"hash":"2173657205164331952","title":"Neuromuscular signaling and development","description":"The top GO terms cluster around nervous system function and muscle structure\u2014mechanosensory detection, nerve impulse transmission, synapse assembly, sarcomere organization, and skeletal/muscle development, along with regulation of sodium transport\u2014pointing to neuromuscular development and signaling. Some immune-related terms appear, likely as shared components or incidental associations, but the dominant theme is neuromuscular biology.","confidence":"Medium","size":23,"edges":10,"triangles":2,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":12},{"id":"GO:0002377","count":12},{"id":"GO:0007275","count":12},{"id":"GO:0046718","count":11},{"id":"GO:0019226","count":11}]},{"hash":"1119041962848512779","title":"Neuronal signaling and ion transport","description":"This cluster is dominated by GO terms related to sensory detection of sound, transmission of nerve impulses, membrane depolarization, excitatory postsynaptic potentials, and sodium/potassium ion transport, pointing to neural signaling and ion channel activity as the core theme. A couple of outlier terms (symbiont entry into host cell, kidney development) may reflect annotation noise or multifunctional proteins. ","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":8},{"id":"GO:0019226","count":7},{"id":"GO:0046718","count":7},{"id":"GO:0001822","count":7},{"id":"GO:0060079","count":6}]},{"hash":"1897889201244408963","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms point to diverse aspects of embryonic development and tissue formation (placental and endocrine development, cartilage morphogenesis, EMT in cardiac cushions, left-right patterning, and pancreatic cell development), suggesting a shared theme of developmental differentiation and morphogenesis across tissues. A few terms (RNA Pol II regulation, splicing) are auxiliary, but the dominant signal is embryonic development, supporting this label.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0003323","count":4}]},{"hash":"1139250130971609","title":"GPCR Signaling in Thermogenesis and Blood Pressure","description":"The top GO terms cluster around adenylate cyclase-activating GPCR signaling (including dopamine receptor signaling), with strong links to thermogenic responses (diet-induced thermogenesis, cellular response to temperature), cardiovascular regulation (positive regulation of blood pressure), and energy metabolism (electron transport chain). Additional terms touch on prostaglandin signaling and nociceptive pathways, suggesting a core theme of GPCR-driven signaling governing metabolism, heat production, and vascular function. Confidence: High","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0035025","count":17},{"id":"GO:0019233","count":17}]},{"hash":"725587476860561785","title":"Developmental Morphogenesis","description":"This cluster pools GO terms focused on tissue and organ formation in multicellular organisms (neural tube closure, outflow tract morphogenesis, pancreatic cell development, gonad development), as well as related processes like synapse assembly and regulated cell proliferation, all pointing to developmental programs and morphogenesis rather than a single molecular function.","confidence":"High","size":23,"edges":31,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0070317","count":2},{"id":"GO:0000920","count":2},{"id":"GO:0000724","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1559767400196810634","title":"Skeletal development and morphogenesis","description":"This cluster is strongly enriched for developmental processes, especially skeletal system development and morphogenesis, along with multicellular organism development. While there are signaling and cell-cycle related terms (GTPase activity, TORC1 signaling, hypoxia) and a prostate epithelial differentiation term, the dominant themes center on skeletal formation and tissue morphogenesis, justifying a label around skeletal development and morphogenesis.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007568","count":8},{"id":"GO:0051260","count":8},{"id":"GO:0001501","count":7},{"id":"GO:0048705","count":7},{"id":"GO:0060528","count":7}]},{"hash":"1918391823805175719","title":"Innate antiviral and LPS-triggered signaling","description":"The top GO terms point to innate immune recognition and response: antiviral defense (defense response to virus, viral process, dsRNA response) and LPS-related signaling (cellular response to lipopolysaccharide, lipopolysaccharide-mediated signaling, cytokine signaling). While some ribosome biogenesis terms appear, the dominant theme is innate immune signaling in response to viral and bacterial PAMPs.","confidence":"Medium","size":23,"edges":25,"triangles":0,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0019221","count":3},{"id":"GO:0043330","count":3},{"id":"GO:0031663","count":3}]},{"hash":"1325152321315207521","title":"Immune response and MAPK signaling","description":"The top GO terms are dominated by immune-related processes: defense response to protozoan, interferon production, immunoglobulin production, dendritic cell differentiation, and general immune activation. In addition, positive regulation of JNK and ERK cascades points to MAPK signaling involvement in these responses. While a couple of terms relate to development (spermatid, nervous system), these are likely annotation noise; overall the cluster appears to reflect immune defense and signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042832","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0046330","count":3},{"id":"GO:0007286","count":3},{"id":"GO:0032729","count":3}]},{"hash":"1611188984379784029","title":"Coagulation and ECM remodeling","description":"The top GO terms point to blood coagulation, complement activation, and plasminogen activation, along with extracellular matrix disassembly and collagen catabolic processes, plus endothelial barrier regulation. This pattern suggests a coordinated program of hemostasis and extracellular matrix turnover, possibly involving proteolysis and vascular integrity, with one transcription-related term being less central to the cluster.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007596","count":8},{"id":"GO:0030574","count":8},{"id":"GO:0000122","count":7},{"id":"GO:0001867","count":7},{"id":"GO:1903142","count":7}]},{"hash":"1053532905064403886","title":"Growth Factor Signaling and Cell Proliferation","description":"The top GO terms cluster around signaling pathways tied to growth factors (insulin receptor, HGF, VEGF) and their downstream effects on cell proliferation and development (mitotic progression, transcription, mammary gland proliferation, multicellular development). This suggests proteins in the cluster participate in growth factor\u2013mediated signaling and regulation of the cell cycle in multicellular organisms. The pollen recognition term appears as an outlier, likely annotation noise rather than a core function of the group.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046626","count":4},{"id":"GO:0035729","count":4},{"id":"GO:0048544","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0048010","count":4}]},{"hash":"1537812303669790116","title":"Cardiovascular GPCR Signaling and Blood Pressure Regulation","description":"The top GO terms point to GPCR-mediated signaling that activates adenylate cyclase and regulates blood pressure (GO:0045777, GO:0010579), as well as Rho-dependent signaling (GO:0035025), indicating pathways that control vascular tone and cardiovascular function through GPCR/cAMP signaling. Other terms related to membrane potential, visual perception, and pain regulation suggest neural signaling components within the cluster, while electron transport chain term may reflect general cellular energy requirements for signaling proteins. Together, the terms imply a coherent theme of GPCR-driven signaling linked to blood pressure regulation, with accompanying neural signaling activities.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":11},{"id":"GO:0010579","count":10},{"id":"GO:0035025","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0051930","count":8}]},{"hash":"1099691261154545884","title":"Developmental differentiation and signaling","description":"The top GO terms center on development and differentiation (fat cell, cerebellar granule cell, and male gonad development) and on signaling (Wnt pathway), with supporting terms for cellular response and RNA processing. This suggests a broad set of proteins involved in developmental signaling and differentiation across tissues, rather than a single, tightly linked function. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0097284","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0021707","count":4}]},{"hash":"1753815510897548942","title":"Telomere maintenance regulation","description":"The cluster shows multiple GO terms tied to telomere maintenance, including positive regulation of telomere maintenance via telomerase, regulation of telomere capping, and regulation of telomere maintenance via telomere lengthening, indicating a coherent focus on telomere biology. Some unrelated terms (e.g., heart development, sensory perception of sound) may reflect broad functional annotations, but the dominant theme is telomere regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055085","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0007605","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0007205","count":2}]},{"hash":"588814958265444318","title":"Unknown","description":"The top GO terms cover a wide range of developmental and cellular processes (apoptotic process, hair follicle morphogenesis, vasculogenesis, nerve organization, muscle-related processes) with no single, coherent function tying the cluster together, and there are no edges or coherent interaction signals to define a specific theme. Therefore, there isn\u2019t a clear, representative label beyond Unknown.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0060044","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0031069","count":4},{"id":"GO:0014809","count":3}]},{"hash":"1655836678359570142","title":"Ciliary/Photoreceptor GPCR trafficking","description":"This cluster is dominated by terms related to cilium assembly and localization to photoreceptor outer segments, plus regulation of GPCR signaling, implying proteins involved in photoreceptor ciliary trafficking and GPCR function. Supporting terms like protein heterooligomerization and unfolded protein response align with membrane/secretory roles, while a few terms (dsRNA response, chlorophyll biosynthesis) appear less related noise.","confidence":"High","size":22,"edges":19,"triangles":0,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0008277","count":7},{"id":"GO:0071360","count":7},{"id":"GO:1903546","count":7},{"id":"GO:0006478","count":7},{"id":"GO:0016576","count":7}]},{"hash":"1560120573907110213","title":"Angiogenesis and Immune Regulation","description":"The cluster shows strong signals for blood vessel formation and VEGF-related signaling, plus multiple immune-related processes (T cell receptor signaling regulation, macrophage activation, B cell differentiation, neutrophil clearance) and cytoskeletal/transcription activities, indicating a coordinated vascular-immune development program.","confidence":"High","size":22,"edges":52,"triangles":41,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001525","count":7},{"id":"GO:0050860","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0035789","count":5},{"id":"GO:0038091","count":5}]},{"hash":"1171952314095963637","title":"Unknown","description":"The top GO terms are highly diverse, covering viral process, several developmental contexts (forebrain development, germ-line niche homeostasis, vitellogenesis), signaling regulation (BMP pathway), immune-related phagocytosis, and basic cellular processes (DNA repair, cell growth, metabolism). This lack of a single cohesive biological theme means there isn\u2019t a clear, representative label for the cluster beyond Unknown.","confidence":"","size":22,"edges":28,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0060250","count":2}]},{"hash":"1527925441598877383","title":"Female reproductive development and xenobiotic metabolism","description":"These proteins cluster around female gonad and mammary gland development, hepatocyte differentiation, and lipid-mediated signaling (prostaglandin biosynthesis), along with various xenobiotic and toxin catabolic processes (alkaloids, dioxins, omega-oxidation). The convergence of development in gland/tert tissues with detoxification and metabolic pathways suggests a coherent theme of hormone-regulated gland development linked to xenobiotic metabolism.","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":16},{"id":"GO:0001516","count":15},{"id":"GO:0042738","count":14},{"id":"GO:0009822","count":14},{"id":"GO:0030879","count":14}]},{"hash":"937093160390858548","title":"Vertebrate embryonic patterning and craniofacial morphogenesis","description":"Dominant GO terms point to embryonic patterning and craniofacial morphogenesis in vertebrates (primitive streak formation, rhombomere development, brain segmentation, viscerocranium morphogenesis, roof of the mouth), underpinned by transcriptional regulation via RNA polymerase II; a plant-specific term appears as an outlier.","confidence":"High","size":22,"edges":220,"triangles":1343,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0090009","count":12},{"id":"GO:0060021","count":11},{"id":"GO:0048703","count":11},{"id":"GO:0021571","count":10}]},{"hash":"584021749912554193","title":"Spliceosome Regulation and mRNA Processing","description":"This cluster is dominated by GO terms relating to splicing regulation (both positive and negative) via the spliceosome, as well as mRNA stability, export, and alternative splicing, plus related steps in translation initiation. The shared theme is RNA processing and post-transcriptional regulation, centered on spliceosome-mediated splicing control and mRNA maturation; some terms touch translation context, but the core signal is RNA processing machinery.","confidence":"High","size":22,"edges":22,"triangles":3,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0048025","count":19},{"id":"GO:0031047","count":19},{"id":"GO:0075525","count":18},{"id":"GO:0001825","count":18}]},{"hash":"609377762579830529","title":"Mammary gland epithelial cell cycle progression","description":"Most terms point to mitosis and cell-cycle control (spindle pole separation, G1/S and G2/M transitions, chromosome condensation, transcription during the cell cycle), with some mammary gland\u2013specific proliferation and development terms, suggesting the proteins function together in driving mammary epithelial cell proliferation via cell-cycle progression. A few signals also touch on insulin signaling and autophagy, which can modulate growth but do not override the core mitotic theme.","confidence":"High","size":22,"edges":46,"triangles":54,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010696","count":18},{"id":"GO:0000320","count":18},{"id":"GO:0006351","count":18},{"id":"GO:0000082","count":18},{"id":"GO:0033598","count":18}]},{"hash":"1075302363675968216","title":"GPCR-cAMP Signaling in Blood Pressure Regulation","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling, activation of adenylate cyclase, and regulation of systemic arterial blood pressure via the renin-angiotensin system, pointing to a shared function in GPCR-mediated cAMP signaling that influences vascular tone and blood pressure. Some terms (electron transport chain; several obsolete or unrelated terms) suggest background metabolism or annotation noise, but the core theme is GPCR-cAMP\u2013driven regulation of blood pressure. ","confidence":"Medium","size":22,"edges":5,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":21},{"id":"GO:0045777","count":21},{"id":"GO:0007190","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0043950","count":19}]},{"hash":"2154220190778699724","title":"Hematopoiesis and immune signaling","description":"The top GO terms cluster around immune- and hematopoietic-related processes: innate immune response, B cell receptor signaling, GM-CSF response, and hemopoiesis. These indicate a group of proteins involved in immune cell development and signaling. Additional terms on Rho signaling, transcriptional regulation, and centrosome-related processes suggest supporting cellular functions, with heart development and sodium transport being less central. ","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0000122","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1293926983080191878","title":"Membrane Receptor Proteolysis in Development","description":"This cluster is driven by GO terms for ectodomain and intracellular domain proteolysis of membrane proteins, which points to regulated intramembrane proteolysis (a Notch-like processing pathway) involved in signaling during development. Supporting terms such as blastocyst formation and radial glia migration align with developmental contexts where such signaling is key. Other terms (blood coagulation, cytokine signaling, splicing regulation, translation initiation) appear peripheral, suggesting some multifunctional annotations but not forming a cohesive alternative theme. Confidence: Medium","confidence":"","size":22,"edges":23,"triangles":1,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0019221","count":2},{"id":"GO:0031293","count":2},{"id":"GO:0006509","count":2},{"id":"GO:0075525","count":2}]},{"hash":"2030970343873259731","title":"Embryogenesis and tissue morphogenesis","description":"The top GO terms point to developmental processes across multiple tissues: cartilage morphogenesis, endocrine system development, placental and heart-associated differentiation (EMT in endocardial cushion formation, trophoblast giant cell differentiation, pancreatic beta cell development), and left-right pattern formation. A couple of terms about RNA Pol II regulation and mRNA splicing suggest transcriptional control during development. Together these terms indicate a cohesive focus on embryonic development and organ/tissue morphogenesis.","confidence":"High","size":22,"edges":35,"triangles":21,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2}]},{"hash":"189683110355510503","title":"Neural development and axon-dendrite patterning","description":"The top GO terms cluster tightly around nervous system development, neurogenesis, and axon/dendrite patterning (ROBO signaling, dendrite self-avoidance, collateral sprouting regulation) plus neural signaling (transmission of nerve impulse) and excitability via clustering of potassium channels, with Hedgehog signaling also tying into developmental patterning. A single muscle-related term appears but does not override the dominant neural connectivity theme. This suggests a coherent module focused on neural development and connectivity.","confidence":"High","size":22,"edges":219,"triangles":1320,"max_degree":21,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":14},{"id":"GO:0022008","count":13},{"id":"GO:0035385","count":13},{"id":"GO:0006915","count":12},{"id":"GO:0048671","count":12}]},{"hash":"67262133216147695","title":"Developmental lineage specification and neural/glial differentiation","description":"The top GO terms point to transcriptional regulation and multiple lineage specification events, especially neural/glial lineages (peripheral nervous system development, oligodendrocyte and astrocyte differentiation) along with other developmental fates (endodermal fate, mammary gland development, stem cell maintenance). This suggests the cluster is enriched for proteins involved in developmental fate decisions and their transcriptional control, with a notable emphasis on neural/glial differentiation, rather than a single specific pathway. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007422","count":4},{"id":"GO:0048709","count":4},{"id":"GO:0046777","count":4},{"id":"GO:0006935","count":4}]},{"hash":"824726949002091547","title":"Cross-tissue development and signaling","description":"This cluster includes GO terms spanning diverse developmental processes across tissues (visual perception, heart development, ossification, fat cell differentiation, keratinization, neural GABAergic signaling) plus general regulatory and membrane-related functions (positive regulation of gene expression, phospholipid homeostasis, endocytosis, protein heterooligomerization). The broad mix suggests a group of proteins involved in general developmental signaling and membrane dynamics across tissues rather than a single, cohesive pathway, hence a cross-tissue developmental label.","confidence":"Low","size":22,"edges":40,"triangles":36,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0055091","count":6},{"id":"GO:0010628","count":6},{"id":"GO:0051932","count":6},{"id":"GO:0045444","count":6}]},{"hash":"1501836385590812451","title":"DNA replication and genome maintenance","description":"The top GO terms are dominated by DNA replication processes (replication, unwinding, primer synthesis, topological changes) and a DNA damage/repair-like SOS response, with UV protection and transcription open complex formation supporting genome integrity maintenance. Some terms like nonsense-mediated decay and immune signaling appear but the core signal points to replication-associated genome maintenance.","confidence":"Medium","size":22,"edges":106,"triangles":253,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0006268","count":5},{"id":"GO:0006269","count":5},{"id":"GO:0009432","count":5},{"id":"GO:0000184","count":5}]},{"hash":"1088619853413110783","title":"Immune signaling and mitochondrial assembly","description":"The top GO terms show a blend of immune signaling (positive regulation of T cell proliferation; regulation of NF-kappaB signaling) together with mitochondrial processes (complex IV assembly; respirasome assembly; regulation of cytochrome c release), plus some cell adhesion and lysosome-related terms. This suggests a cluster of proteins involved in signaling interactions that connect immune pathways with mitochondrial dynamics, rather than a single, narrow function. Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":2},{"id":"GO:2000649","count":2},{"id":"GO:0042102","count":2},{"id":"GO:0033617","count":1},{"id":"GO:0090201","count":1}]},{"hash":"613197726735897990","title":"Neurotransmitter Transport and Synaptic Signaling","description":"The cluster shows a strong enrichment for terms related to neurotransmitter handling and synaptic function (glycine secretion and glycinergic regulation, serotonin uptake/secretion, dopamine catabolic process) along with amino acid transport (proline, leucine) and CNS-related development (thalamus development, perineurial glial growth). This cohesive pattern points to a group of proteins involved in synaptic signaling and neurotransmitter transport in the brain, justifying a label centered on neurotransmitter transport and synaptic signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061537","count":3},{"id":"GO:0042066","count":3},{"id":"GO:0051610","count":3},{"id":"GO:1905847","count":3},{"id":"GO:0015824","count":3}]},{"hash":"959988912192029328","title":"Vertebrate embryogenesis and organogenesis","description":"The top GO terms cluster around embryonic development, tissue differentiation, and organ formation (placental/trophoblast differentiation, cartilage morphogenesis, endocrine system development, heart valve/EMT, pancreatic development, left-right patterning, and sensory development). This indicates a cohesive theme of vertebrate embryonic development and subsequent organogenesis, with some broader regulatory processes like transcriptional control. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"149124954865875861","title":"Cardiac GPCR Signaling and Contraction Regulation","description":"The cluster centers on heart-related biology, with terms for heart development and cardiac muscle contraction, and heavily features G protein-coupled receptor signaling and its modulation (internalization, desensitization, acetylcholine and tachykinin receptor pathways, and related phosphorylation). This points to a cohesive set of proteins involved in GPCR-mediated signaling that regulates cardiac contraction. Therefore, the label Cardiac GPCR Signaling and Contraction Regulation fits well.","confidence":"High","size":22,"edges":24,"triangles":3,"max_degree":11,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0043547","count":6},{"id":"GO:0045988","count":6},{"id":"GO:0003108","count":6},{"id":"GO:0002031","count":6}]},{"hash":"901412427722904366","title":"Unknown","description":"GO terms span neural/glial proliferation, dendritic spine maintenance, muscle development, DNA repair, transcription regulation, immune response, and signaling; the cluster shows no single coherent function, so a specific label cannot be assigned.","confidence":"","size":22,"edges":26,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0060252","count":3},{"id":"GO:0006360","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0070816","count":2},{"id":"GO:0097062","count":2}]},{"hash":"1381384506988784351","title":"NF-\u03baB\u2013regulated immune and developmental signaling","description":"The cluster centers on NF-\u03baB pathway regulation and immune outputs (innate immune response, type II interferon production, immunoglobulin production), suggesting NF-\u03baB\u2013driven signaling roles in immune responses. It also includes several development-related terms (multicellular organism development, corticospinal tract morphogenesis, odontogenesis), implying broader regulatory functions in development. This combination points to a theme of NF-\u03baB\u2013linked signaling coordinating immune and developmental processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007275","count":16},{"id":"GO:0051092","count":15},{"id":"GO:0043123","count":15},{"id":"GO:0098907","count":10},{"id":"GO:0098910","count":10}]},{"hash":"1857551145999194762","title":"Cardiac development and organogenesis","description":"This cluster is enriched for heart-related terms (heart development, pulmonary myocardium development) and broader organogenesis (multicellular organism development, organ induction, cranial skeleton morphogenesis). The inclusion of Rho signaling regulation and cell migration terms fits the cytoskeletal changes and morphogenetic movements typical of cardiac and craniofacial organ development, suggesting a coherent developmental module centered on heart and organ formation.","confidence":"High","size":22,"edges":6,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0001759","count":5},{"id":"GO:0048701","count":5}]},{"hash":"623596487205526210","title":"Nuclear RNA processing and decay","description":"Top GO terms are dominated by nuclear RNA metabolism, including nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic processes, and nuclear polyadenylation-dependent decay, suggesting a core theme of RNA processing/decay in the nucleus. While a few chromatin modification and transcription-related terms appear, they are less prominent, so the strongest signal is nuclear RNA metabolism. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":4},{"id":"GO:0006349","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0071039","count":3},{"id":"GO:0090503","count":3}]},{"hash":"218576162858510134","title":"Viral Translation Initiation and Splicing Regulation","description":"The top GO terms cluster around RNA processing and control of translation, including viral translation initiation/reinitiation and regulation of translational initiation, alongside spliceosome-mediated mRNA splicing and its regulation. This suggests a cohesive theme of RNA maturation and regulation of gene expression at the RNA level, with a notable emphasis on translation initiation in viral contexts (with a minor outlier term related to blastocyst formation).","confidence":"High","size":22,"edges":89,"triangles":87,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":18},{"id":"GO:0001731","count":18},{"id":"GO:0006378","count":18},{"id":"GO:0002188","count":18},{"id":"GO:0075522","count":18}]},{"hash":"173715026122186248","title":"DNA repair and recombination","description":"The GO terms cluster around DNA damage response and recombination: gene conversion at mating-type loci, double-strand break repair, intra-S checkpoint signaling, germ cell development, and isotype switching (class switch recombination), with apoptotic signaling in response to DNA damage. These collectively point to DNA repair/recombination processes activated in germline and immune contexts, with energy (oxidative phosphorylation) supporting these activities. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007534","count":4},{"id":"GO:0031573","count":4},{"id":"GO:0007281","count":4},{"id":"GO:0000735","count":4},{"id":"GO:0006119","count":4}]},{"hash":"1136711375481859691","title":"Embryonic Development and Morphogenesis","description":"The GO terms are all related to developmental processes across multiple tissues (roof of the mouth, cartilage, hair follicles, endocrine organs, heart cushion EMT, left-right patterning, etc.), indicating a shared role in embryogenesis and organ morphogenesis rather than a single tissue-specific function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0060806","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4}]},{"hash":"33474725823931979","title":"CNS development and synaptic regulation","description":"The cluster is dominated by neural-related terms, including ventricular system development and central nervous system development, plus a strong signal for regulation of synaptic plasticity by receptor localization to the synapse. Additional terms point to neuronal maintenance and gene regulation activities (mitophagy, ubiquitin-dependent degradation, mRNA processing, and histone modification), suggesting a theme around brain development and synaptic function with supporting cellular regulation processes. Confidence in this thematic label is medium due to the presence of some non-neuronal terms that could reflect broader cellular housekeeping or data noise.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021591","count":3},{"id":"GO:0051568","count":3},{"id":"GO:0001756","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0006397","count":2}]},{"hash":"1337292695599265985","title":"Embryogenesis and Organogenesis Regulators","description":"This cluster is driven by GO terms tied to embryonic development and tissue differentiation (placenta, cartilage morphogenesis, endocrine development, EMT in endocardial cushion formation, left-right patterning, pancreatic cell development, trophoblast differentiation). It also includes transcription and RNA processing regulation (RNA Pol II regulation, mRNA splicing), suggesting a group of proteins that coordinate gene expression programs during development. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:1903026","count":21},{"id":"GO:0000398","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0060536","count":21},{"id":"GO:0035270","count":21}]},{"hash":"1230204012323342686","title":"Cardiovascular signaling and development","description":"This cluster is dominated by GO terms related to heart development, blood pressure regulation, platelet activation, and signaling pathways (ERK cascade, GPCR signaling, Rho GTPase activity), pointing to a cohesive cardiovascular signaling and development theme; a few terms like electron transport chain may reflect shared cellular metabolism but are not central to the main theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0030168","count":4},{"id":"GO:0010579","count":4},{"id":"GO:0045777","count":4},{"id":"GO:0035025","count":4}]},{"hash":"1692661411799666098","title":"Wnt signaling in adipogenesis and muscle differentiation","description":"The top GO term is the Wnt signaling pathway, with strong support from fat cell differentiation and muscle-related responses, plus a note of cell migration and telomere maintenance associations that commonly intersect with Wnt-regulated development. This pattern suggests a coherent cluster of proteins involved in Wnt-driven adipogenesis and muscle differentiation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016055","count":7},{"id":"GO:1904743","count":6},{"id":"GO:0007205","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0070213","count":6}]},{"hash":"799063332987630852","title":"Circadian ubiquitin-mediated proteolysis","description":"The cluster is driven by GO terms for ubiquitin-dependent protein catabolic processes and protein polyubiquitination, including SCF-dependent proteasomal ubiquitin-driven degradation, pointing to a core theme of ubiquitin-proteasome\u2013mediated protein turnover. The circadian rhythm regulation term reinforces a link to clock protein turnover and timing control. Some unrelated terms may reflect multi-functionality of ubiquitin pathway components, but the strongest shared function is circadian-regulated proteolysis.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0051260","count":8},{"id":"GO:0042752","count":8},{"id":"GO:0000209","count":6},{"id":"GO:0031146","count":6}]},{"hash":"545254381135623701","title":"Presynaptic vesicle exocytosis and synaptic plasticity","description":"The GO terms point to presynaptic secretion, neurotransmitter release, dense-core vesicle exocytosis, and synapse organization, with notes on synaptic depression and plasticity. This supports a cohesive role in presynaptic vesicle trafficking and neurotransmitter release, linked to synaptic remodeling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0060292","count":3},{"id":"GO:0006887","count":3},{"id":"GO:0035773","count":2},{"id":"GO:0007269","count":2}]},{"hash":"2271989356148998374","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038016","count":1},{"id":"GO:0042733","count":1},{"id":"GO:0046627","count":1},{"id":"GO:0051898","count":1},{"id":"GO:0046325","count":1}]},{"hash":"897939280752485688","title":"B cell activation and inflammatory signaling","description":"This cluster centers on B cell\u2013specific processes (positive regulation of B cell proliferation, B cell receptor signaling) and inflammatory responses (cellular response to interleukin-1, response to muramyl dipeptide). It also includes regulatory actions on signaling pathways (negative regulation of Ras and GTPase activity, phosphatase activity) and hints of broader crosstalk with Wnt signaling and protein catabolic processes, suggesting a theme of B cell\u2013driven immune activation with modulation of signaling networks.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030890","count":3},{"id":"GO:0071347","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0032495","count":3},{"id":"GO:0008285","count":2}]},{"hash":"1430945776414191516","title":"Neural development and synapse formation","description":"The terms cluster around brain development and neural connectivity: corpus callosum development, axonal fasciculation, neurite/axon regulation, neurotransmitter secretion, and especially synapse assembly, with supporting pathways like Wnt signaling. A few entries (e.g., sensory perception of sound) may be less central and could reflect broader or context-specific annotations, but the core theme points to neural development and synaptic wiring.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0048671","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0007269","count":2},{"id":"GO:0022038","count":2}]},{"hash":"246226314034911873","title":"Cross-tissue development and differentiation","description":"This cluster is dominated by GO terms about developmental and morphogenetic processes across various tissues (heart development, lens morphogenesis and differentiation, spermatid development, cuticle pattern formation), with some regulatory and functional terms that are ancillary to development (e.g., regulation of heart rate, macrophage activation). The common thread is differentiation and morphogenesis across multiple tissues, rather than a single, cohesive pathway, so a cross-tissue developmental label is most representative.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086015","count":3},{"id":"GO:0060307","count":3},{"id":"GO:0086091","count":3},{"id":"GO:0060371","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1005314535582811471","title":"Vertebrate Development and Tissue Morphogenesis","description":"The top GO terms cluster around embryonic development and tissue formation, including neural tube closure, hair follicle morphogenesis, skin barrier establishment, and angiogenesis with endothelial migration. This suggests proteins contributing to developmental morphogenesis, particularly skin/hair formation and vascular development, rather than a single pathway.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0061436","count":2},{"id":"GO:0031069","count":2}]},{"hash":"760383559123472352","title":"Vesicle trafficking and exosome secretion","description":"The cluster is dominated by GO terms for Golgi vesicle budding, exosomal secretion, and regulation of vesicle exocytosis, pointing to a shared role in membrane trafficking and cargo release. Supporting terms about dendrite development, satellite cell migration, and keratinization suggest trafficking processes underpin development and tissue remodeling. Mitochondrion organization and protein heterooligomerization further align with the machinery and energy needs of vesicle transport systems. Overall, the common thread appears to be vesicle trafficking and secretory pathways across development-related contexts.","confidence":"Medium","size":21,"edges":46,"triangles":34,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048194","count":21},{"id":"GO:1902766","count":21},{"id":"GO:0035690","count":21},{"id":"GO:0051291","count":21},{"id":"GO:0016358","count":21}]},{"hash":"1614947398166339545","title":"Vesicle trafficking and exocytosis regulation","description":"The top GO terms cluster around regulated vesicle formation and transport (calcium-dependent exocytosis, ER-Golgi transport, synaptic vesicle budding, endosome-to-lysosome transport, lysosomal organization) and are supported by small GTPase signaling that governs trafficking and by podosome-related cytoskeletal remodeling. These collectively indicate a theme of intracellular membrane trafficking and vesicle dynamics as the shared function of the cluster.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":4},{"id":"GO:0007264","count":3},{"id":"GO:1902824","count":3},{"id":"GO:0071803","count":3},{"id":"GO:1990386","count":3}]},{"hash":"815986536511288275","title":"Unknown","description":"The top GO terms cover lipid homeostasis, gene expression regulation, ERK signaling, insulin signaling, visual perception, acrosome assembly, apoptosis, and fatty acid oxidation. The mixture shows no single dominant function or pathway, so there is no cohesive theme to name the cluster; thus, Unknown. ","confidence":"","size":21,"edges":15,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055091","count":4},{"id":"GO:0010628","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0008286","count":3}]},{"hash":"2124866401947219584","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":6},{"id":"GO:0033129","count":5},{"id":"GO:0070935","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0097350","count":4}]},{"hash":"703927527880692736","title":"Regulators of cell proliferation and signaling","description":"The cluster is dominated by GO terms about promoting or regulating cell proliferation and signaling, including positive regulation of cell population proliferation and positive regulation of GTPase activity, suggesting core regulatory proteins that modulate growth and signaling pathways. The presence of terms spanning appetite, retina development, inflammatory response, blood pressure regulation, and T cell differentiation implies broad regulatory roles across tissues rather than a single tissue-specific function. Therefore, a label focusing on growth and signaling regulation best represents the cluster.","confidence":"Medium","size":21,"edges":185,"triangles":954,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008284","count":20},{"id":"GO:0032100","count":20},{"id":"GO:0008283","count":20},{"id":"GO:0043547","count":20},{"id":"GO:0060041","count":20}]},{"hash":"697587520825484093","title":"Cardiovascular regulation and energy metabolism","description":"This cluster centers on processes governing vascular and renal homeostasis (blood pressure regulation, renal sodium excretion, coagulation) and GPCR-adenylyl cyclase signaling, with supporting links to energy metabolism (electron transport chain, diet-induced thermogenesis). The presence of monocyte chemotaxis and phospholipase C activation suggests inflammatory signaling connected to vascular function, reinforcing a cardiovascular\u2013metabolic theme. Overall, the proteins appear tied to cardiovascular regulation alongside energy production pathways, justifying the label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":16},{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0090026","count":14},{"id":"GO:0035815","count":14}]},{"hash":"1970371088058590871","title":"Embryonic organ morphogenesis","description":"Based on the top GO terms, these proteins are enriched for embryonic development and morphogenesis across multiple organs (endocrine pancreas, digestive tract, retina, neural crest, palate, uterus, gonads). This points to a broad role in embryonic organogenesis rather than a single tissue-specific function. The diversity of tissues suggests a general developmental regulatory function coordinating organ formation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0031018","count":7},{"id":"GO:0048557","count":7},{"id":"GO:0001755","count":7},{"id":"GO:0090190","count":7}]},{"hash":"1036364666385210430","title":"Notch-driven tissue development","description":"The cluster shows a strong enrichment for Notch signaling (GO:0007219) together with multiple development-related terms across different tissues (bronchiole development, neural retina development, glial cell fate commitment, metanephric nephron tubule morphogenesis), plus transcriptional regulation and other differentiation controls. This pattern suggests proteins that participate in signaling networks governing organogenesis and cell fate decisions, with Notch signaling as a central theme, even though some terms reflect broader regulatory roles. ","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":16},{"id":"GO:0060766","count":16},{"id":"GO:0006366","count":15},{"id":"GO:0007219","count":14},{"id":"GO:0072282","count":14}]},{"hash":"1995178403448394609","title":"Spindle dynamics and cytokinesis","description":"This cluster shows strong representation of microtubule- and motor-based processes driving mitotic/meiotic spindle assembly and orientation (e.g., spindle pole body separation, plus-end microtubule activities, meiotic spindle orientation) and the actomyosin contractile ring that mediates cytokinesis. Additional terms touch cytoskeletal remodeling and cell\u2013cell junction maintenance, supporting a cohesive theme of spindle organization coupled to cytokinesis and cell adhesion during division. ","confidence":"High","size":21,"edges":73,"triangles":166,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0000073","count":21},{"id":"GO:0001560","count":21},{"id":"GO:0070462","count":21},{"id":"GO:0000915","count":21},{"id":"GO:0033624","count":21}]},{"hash":"1591944675323408124","title":"Metabolism-Linked Signaling","description":"The top GO terms span central metabolism (TCA cycle, amino acid catabolism, glyoxylate cycle) and various signaling and stress responses (Notch signaling, growth factor response, xenobiotic response, neurotransmitter loading). This pattern suggests a cluster where metabolic state interfaces with signaling and cellular stress/response processes, rather than a single isolated pathway.","confidence":"Medium","size":21,"edges":204,"triangles":1219,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":5},{"id":"GO:0097053","count":5},{"id":"GO:0042853","count":5},{"id":"GO:0009436","count":5},{"id":"GO:0006099","count":4}]},{"hash":"1295681586315426866","title":"Nervous system and muscle development","description":"The top GO terms cluster around developmental processes across multiple tissues, especially nervous system components (forebrain development, myelination in PNS) and skeletal muscle development, with supporting terms for heart development and sensory perception. While signaling terms are present, the strongest shared theme is tissue development, notably in nervous and muscular systems, justifying the label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0007601","count":5},{"id":"GO:0007605","count":5},{"id":"GO:0071380","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1365576161210788479","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around nervous system development (inner ear, brain/midbrain, motor-related structures), neuron adhesion, and glutamatergic synaptic transmission, pointing to a shared role in neurodevelopment and synaptic communication. Some terms are broader (transcription regulation, endothelial barrier), but the dominant theme is neural development and synaptic function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048839","count":7},{"id":"GO:0007626","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0000122","count":6},{"id":"GO:1903142","count":5}]},{"hash":"1032588593848307816","title":"Embryonic eye and organ morphogenesis","description":"This cluster is enriched for eye development terms (camera-type eye development and embryonic eye morphogenesis) while also showing broader embryonic organogenesis signals (lung morphogenesis, vascular development, floor plate, somitogenesis, amacrine cell differentiation, cardiac muscle morphogenesis), suggesting a general developmental program with a prominent eye-specific component.","confidence":"High","size":21,"edges":209,"triangles":1311,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0043010","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0060441","count":8},{"id":"GO:0035470","count":8}]},{"hash":"2047717561551576509","title":"Eye development and lens morphogenesis","description":"This cluster is dominated by GO terms tied to ocular development, including embryonic eye morphogenesis, camera-type eye development, and positive regulation of lens epithelial cell proliferation, suggesting a cohesive role in eye and lens formation during embryogenesis. While some terms touch on broader embryonic development, the strongest signals consistently point to eye morphogenesis and lens biology, justifying a label focused on eye development. Confidence in this interpretation is High.","confidence":"High","size":21,"edges":199,"triangles":1129,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":12},{"id":"GO:0006366","count":11},{"id":"GO:0043010","count":10},{"id":"GO:0060441","count":10},{"id":"GO:0055010","count":9}]},{"hash":"1706909436081046248","title":"Embryonic organ morphogenesis","description":"The proteins are collectively linked to embryonic development and morphogenesis across multiple organs (eye, heart, hindlimb, placenta, digestive tract, roof of mouth), with one term indicating transcriptional regulation during development, suggesting these proteins function in organogenesis and developmental gene control.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0048048","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0003148","count":5}]},{"hash":"76817053716812399","title":"Neuroimmune Signaling and Synapse Development","description":"Top GO terms show a mix of innate immune responses and lipopolysaccharide/dsRNA signaling alongside neural development and synapse assembly processes, suggesting the proteins are involved in neuroimmune communication that modulates axon growth, corpus callosum development, and synaptic organization, with potential links to dopamine signaling and pain-related behaviors.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:1903351","count":2},{"id":"GO:0043330","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0022038","count":2}]},{"hash":"1893256714034842623","title":"Developmental signaling and cell junctions","description":"The top GO terms point to broad developmental processes (multicellular organism development, substantia nigra and spermatid development, ossification) alongside signaling pathways (Fc-epsilon receptor signaling, Rho signaling) and a cell-adhesion term (bicellular tight junction assembly). This pattern suggests a cluster of proteins involved in development and tissue formation with supporting signaling and adhesion roles, rather than a single precise function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0021762","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007275","count":3}]},{"hash":"1695433681360391604","title":"Mitotic Cell Cycle and Translation Initiation","description":"The cluster shows strong enrichment for mitosis- and cell-cycle related GO terms (mitotic cell cycle, cell division, anaphase-promoting complex\u2013dependent catabolic process) and for translation-related terms (formation of translation preinitiation complex, translation reinitiation, mRNA transport). This suggests proteins in the cluster coordinate cell-cycle progression with translation control. A few terms like skin development and obsolete ERAD may be background noise but do not override the dominant mitosis/translation theme.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0043588","count":7},{"id":"GO:0030433","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0051028","count":6}]},{"hash":"436319546008703552","title":"Neural-immune cell adhesion and signaling","description":"The cluster\u2019s top GO terms cluster around cell-surface adhesion and signaling in neural-immune contexts\u2014paranodal junction assembly, integrin-mediated signaling, innate immune response, and receptor-mediated interactions\u2014supported by microglia development, protein localization to lysosomes, and virion attachment, suggesting a cohesive theme of neural-immune adhesion and receptor signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":4},{"id":"GO:2001046","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007155","count":4},{"id":"GO:1901223","count":3}]},{"hash":"48743115010227377","title":"Embryonic Development and Tissue Morphogenesis","description":"The dominant GO terms point to broad embryonic organogenesis and tissue shape changes (palate formation, cartilage, hair follicle morphogenesis, placental and endocrine development, heart cushion EMT, left-right patterning), suggesting proteins function in developmental morphogenesis rather than a single pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":6},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"525768964962985235","title":"Notch-Regulated Multi-Tissue Differentiation","description":"This cluster is dominated by differentiation-related GO terms across multiple tissues (muscle, pancreas, melanocytes, astrocytes, nephron) and features Notch signaling as a central theme, hinting at developmentally regulated transcriptional programs. The presence of RNA polymerase II transcription and stress/response to signals (cytokine IL-4, xenobiotic) suggests coordinated gene expression during differentiation and lineage specification, rather than a single specialized pathway.","confidence":"Medium","size":21,"edges":209,"triangles":1311,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0035914","count":11},{"id":"GO:0031018","count":10},{"id":"GO:0030318","count":9},{"id":"GO:0071353","count":9}]},{"hash":"2275779138052806372","title":"Spliceosome-Regulated RNA Processing in Development","description":"The cluster is dominated by terms related to RNA splicing via the spliceosome (positive and negative regulation, alternative splicing) and mRNA export, with supporting terms on translation initiation and a developmental context (multicellular development, blastocyst formation). This suggests a group of proteins coordinating RNA processing and export during development. ","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0075525","count":1},{"id":"GO:0048025","count":1},{"id":"GO:0001825","count":1}]},{"hash":"2093028962858185626","title":"Ribosome Biogenesis and rRNA Processing","description":"This cluster is strongly defined by GO terms for maturation of LSU rRNA and 5.8S rRNA and for ribosomal large subunit biogenesis, indicating a core function in ribosome assembly and rRNA processing in the nucleolus/nucleus. Additional terms touch on nuclear transport and ubiquitination, which may accompany ribosome production, but the dominant signal is ribosome biogenesis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000463","count":5},{"id":"GO:0033160","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0000466","count":4}]},{"hash":"1145817957603811896","title":"CNS Neuron Development and Ubiquitin Regulation","description":"The cluster features strong signals for nervous system development (hippocampus development, cortical layer formation, dendrite morphogenesis, CNS projection neuron axonogenesis, neural tube closure, visual perception) alongside ubiquitin-related processes (protein sumoylation, deubiquitination, ERAD pathway), suggesting a group of proteins coordinating neuronal development with ubiquitin/SUMO-mediated regulation.","confidence":"Medium","size":21,"edges":200,"triangles":1161,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":5},{"id":"GO:0021766","count":4},{"id":"GO:0016579","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0021819","count":3}]},{"hash":"2079151403352055516","title":"Planar cell polarity and neural development signaling","description":"The top GO terms center on planar cell polarity establishment and neural development (e.g., cerebellar granule cell differentiation, neural plate elongation) with signaling components (Rap, GTPase activation, Wnt/JNK). Although general transcription-related terms are present, the cohesive theme is developmental signaling and cell polarity, particularly PCP-related processes and neural/wing patterning.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0090163","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0022007","count":2}]},{"hash":"504638213531182508","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around embryonic development, placental differentiation, tissue morphogenesis (cartilage, palate, heart EMT), and patterning (left-right), indicating a broad theme of embryogenesis and organogenesis. A couple terms (splicing, coagulation) are more general, but the dominant signal is developmental and morphogenetic processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":8},{"id":"GO:0060806","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003198","count":6}]},{"hash":"1335879946180435289","title":"Developmental Morphogenesis and Signaling","description":"The GO terms cluster around tissue morphogenesis and signaling during development\u2014Wnt pathway regulation, cochlea and cartilage morphogenesis, EMT in heart development, endocrine system development, and Rho-mediated signaling\u2014with exocytosis and protein localization regulation supporting cellular organization during embryogenesis. This cohesive theme justifies a label focused on developmental morphogenesis and signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030111","count":3},{"id":"GO:0090103","count":3},{"id":"GO:0060997","count":3},{"id":"GO:2000009","count":3},{"id":"GO:0035023","count":3}]},{"hash":"1197589745505119804","title":"Cell-Cell Junctions and Actin Dynamics","description":"Top GO terms point to tight junction assembly, immunological synapse formation, and actin-driven motility, all tied to regulation of GTPase activity and various signaling pathways (including insulin signaling and developmental processes). This suggests a cohesive theme around cell-cell adhesion, junction formation, and cytoskeleton remodeling that facilitates cell communication and movement during development. The presence of heart development and neuron projection terms supports a broader developmental context where junctions and actin dynamics are crucial.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0070830","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0001771","count":3},{"id":"GO:0042997","count":3}]},{"hash":"1471214734994776254","title":"Actin Cytoskeleton Remodeling and Adhesion","description":"This cluster centers on actin cytoskeleton dynamics (reorganization, polarity, lamellipodium morphogenesis), cell adhesion, and related synaptic/immune interface processes (long-term synaptic depression, immunological synapse). The presence of positive regulation of peptidyl-tyrosine phosphorylation supports signaling upstream of these events, suggesting a role in actin-driven cell movement and adhesion in neural and immune contexts.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050731","count":4},{"id":"GO:0007155","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0030950","count":3},{"id":"GO:0060292","count":3}]},{"hash":"488108485108157790","title":"Immune-vascular signaling and cytoskeletal dynamics","description":"This cluster combines immune-related signals (positive regulation of TNF production, B cell maturation, IL-7 response) with vascular/heart development cues (heart development, endothelial barrier establishment) and broad signaling pathways (small GTPases, insulin/IGF signaling) linked to cell migration and actin cytoskeleton organization. Together they point to signaling networks that coordinate immune activity, vascular development, and cytoskeletal remodeling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032760","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0048009","count":4},{"id":"GO:0090557","count":3}]},{"hash":"142308727514129995","title":"Proteostasis and DNA damage response","description":"Enriched for proteostasis (protein unfolding, aggresome assembly) and DNA repair (UV-damage excision), with signals for transcription and ribosome biogenesis, suggesting a cellular maintenance and stress-response program.","confidence":"Medium","size":20,"edges":162,"triangles":729,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0006633","count":4},{"id":"GO:0000027","count":4}]},{"hash":"2258453065717164220","title":"Inflammatory Angiogenesis and Remodeling","description":"The GO terms indicate simultaneous activation of blood vessel sprouting (angiogenesis) and immune/inflammatory responses (immunological synapse formation, acute inflammatory response), along with remodeling processes (EMT, zymogen activation, complement activation) and associated lipid handling (lipoprotein transport, cholesterol storage). This suggests a cohesive cluster of proteins coordinating vascular growth with immune signaling and tissue remodeling in inflammatory contexts.","confidence":"High","size":20,"edges":21,"triangles":1,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002040","count":15},{"id":"GO:0001771","count":12},{"id":"GO:0010886","count":12},{"id":"GO:0042953","count":12},{"id":"GO:0002438","count":12}]},{"hash":"1077565377637684129","title":"Cartilage ECM Remodeling and Immune Signaling","description":"The cluster centers on cartilage-related processes (cartilage condensation, collagen fibril organization) and collagen-activated receptor signaling, pointing to extracellular matrix remodeling in cartilage. Concurrent innate immune terms (innate immune response, immunological synapse formation) suggest immune signaling interfaces with ECM dynamics. Some lipoprotein-related terms are present but do not override the ECM/immune theme, making the name a concise reflection of the dominant functions.","confidence":"Medium","size":20,"edges":36,"triangles":0,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0043277","count":4},{"id":"GO:0038063","count":3},{"id":"GO:0001771","count":3}]},{"hash":"154736130993220175","title":"Developmental transcriptional regulation","description":"The cluster features GO terms for DNA-templated transcription, transcriptional repression, and chromatin remodeling, coupled with multiple development-related terms across tissues (cartilage, pancreas, muscle, lung, etc.), implying proteins that regulate transcription during development rather than a single tissue function.","confidence":"High","size":20,"edges":155,"triangles":655,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0060534","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0070384","count":5},{"id":"GO:0031018","count":5}]},{"hash":"259076626174540785","title":"Innate immune signaling and cytokine production","description":"Based on the top GO terms, the cluster centers on innate immune responses to muramyl dipeptide and regulation of cytokine production (IL-6, IL-8, IL-1\u03b2), indicating an immune signaling theme. Additional terms point to intracellular transport and GTPase activation, suggesting these proteins may participate in trafficking processes that influence signaling or cytokine gene regulation. While there are a few outliers (e.g., neuron differentiation), the dominant signal ties immune sensing to cytokine production, with supporting roles in cellular transport. ","confidence":"Medium","size":20,"edges":32,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071225","count":2},{"id":"GO:0032979","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0045666","count":2}]},{"hash":"1790829879351904518","title":"Neural development and synaptic plasticity","description":"This cluster centers on brain development and synaptic function: terms for intracellular signaling and long-term potentiation/depression, along with cerebellar granule cell differentiation and midbrain morphogenesis. Cytoskeletal remodeling and cell migration support neuronal wiring, while behavior terms (social and vocalization) imply roles in neural circuits. ","confidence":"High","size":20,"edges":62,"triangles":101,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":2},{"id":"GO:0060292","count":2},{"id":"GO:1900273","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0021707","count":2}]},{"hash":"933586022057979379","title":"Embryonic development and organ formation","description":"The terms cluster around development-related processes, including germ-line stem cell niche homeostasis, asymmetric division, heart formation, angiogenesis, and skeletal muscle differentiation, suggesting a shared theme of developmental morphogenesis and tissue formation. Some terms about post-translational targeting appear, but the dominant signal is broad developmental capability rather than a single pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060250","count":2},{"id":"GO:0006620","count":1},{"id":"GO:0031204","count":1},{"id":"GO:0007084","count":1},{"id":"GO:0030512","count":1}]},{"hash":"1109539239245105969","title":"Rho/Ras signaling and transcription regulation","description":"The cluster centers on GO terms related to regulation of Rho and Ras signaling, along with transcriptional regulation and protein tetramerization, suggesting a module of proteins involved in signal transduction and gene regulation, possibly including transcription factor complexes. While there are some development- and sensory-related terms present, they appear less central to the primary theme and may reflect broader functional contexts or annotation noise.","confidence":"Medium","size":20,"edges":6,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0046580","count":4},{"id":"GO:0051262","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0042391","count":3}]},{"hash":"192091024755419981","title":"Metal ion transport and calcium homeostasis","description":"Top GO terms emphasize metal ion transport and homeostasis, including cadmium and zinc transmembrane transport and intracellular calcium ion homeostasis, which together suggest a cluster focused on metal ion handling. Additional terms cover broad enzymatic activities (proteolysis, dephosphorylation) and various biosynthetic or catabolic processes, but the metal transport/homeostasis theme is the strongest unifying signal across the proteins.","confidence":"High","size":20,"edges":156,"triangles":669,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0070574","count":3},{"id":"GO:0006874","count":3},{"id":"GO:0016311","count":3},{"id":"GO:0033574","count":3}]},{"hash":"1430492529845367408","title":"Embryonic Morphogenesis and Developmental Regulation","description":"This cluster groups proteins tied to embryonic development and tissue morphogenesis across multiple lineages (palate, cartilage, placenta, endocardial EMT) and includes associated gene-expression regulation processes (RNA splicing and transcription). The common thread is developmental regulation rather than a single tissue-specific function.","confidence":"Medium","size":20,"edges":29,"triangles":0,"max_degree":14,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060021","count":18},{"id":"GO:0000055","count":16},{"id":"GO:0000398","count":16},{"id":"GO:0003323","count":16},{"id":"GO:0060536","count":16}]},{"hash":"2221804600826641985","title":"Unknown","description":"The terms are scattered across diverse developmental processes (blastocyst formation, lens morphogenesis, endocardial EMT), immune signaling (dendritic cell differentiation, TCR pathway regulation, mast cell degranulation), signaling pathways (BMP, thyroid hormone response), and protein turnover (ubiquitin-dependent proteolysis) with no clear common function or interaction pattern, so no cohesive cluster label can be confidently assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0003198","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0001825","count":2},{"id":"GO:0097067","count":2}]},{"hash":"1886577773166756960","title":"Nucleolar RNA Processing and Ribosome Biogenesis","description":"The top GO terms cluster around RNA processing (splicing and rRNA processing) and ribosome biogenesis/export, indicating nucleolar functions tied to RNA handling and ribosome assembly, with some transcriptional regulation links that fit into broader nuclear coordination.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0061188","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0006364","count":2}]},{"hash":"1872599201466599458","title":"Developmental signaling and tissue morphogenesis","description":"The terms coalesce around development and organ formation: heart development, face development, placenta development, and response to retinoic acid\u2014an important morphogenic signal in embryogenesis. Additional signaling pathways (ephrin receptor signaling; cellular responses to nitric oxide and interleukin-7) support tissue patterning and cell signaling during development. A few terms relate to broader cellular transport or immune signaling (transcytosis, B cell receptor signaling) but do not override the central developmental theme.","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071300","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0050853","count":7},{"id":"GO:0001893","count":6},{"id":"GO:0060324","count":6}]},{"hash":"2154403566311698361","title":"Eye and ear development with retinoic acid signaling","description":"The GO terms emphasize eye lens development, light detection, and sensory perception of sound, together with retinoic acid\u2013mediated signaling, suggesting a developmental program coordinating sensory organ formation. Supporting terms for GTPase activity, phospho-tyrosine regulation, TGF-beta response, and microtubule severing point to broader developmental signaling and cytoskeletal dynamics common to these processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032526","count":2},{"id":"GO:0002088","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0007268","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1700246199693692331","title":"EGFR and Ephrin RTK Signaling in Cell Migration","description":"The cluster centers on receptor tyrosine kinase signaling pathways (EGFR and ephrin) and downstream small GTPase\u2013mediated signaling, which regulate cell migration, polarity, and actin dynamics (podosome assembly). Together with related processes like epithelial polarity and phagocytic signaling, these terms point to a cohesive theme of RTK/GTPase-driven cell movement and boundary organization.","confidence":"High","size":20,"edges":7,"triangles":1,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060348","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0007173","count":11},{"id":"GO:0007264","count":11}]},{"hash":"2190975551715361631","title":"RNA Processing and Trafficking Machinery","description":"This cluster shows strong representation for RNA processing and ribosome-related processes (spliceosomal snRNP assembly, ribosome biogenesis, nuclear export), alongside membrane trafficking and cytoskeleton-related activities (endocytic recycling, plasma membrane tubulation, Arp2/3-mediated actin nucleation, cilium localization). Taken together, the proteins appear to participate in RNA maturation and intracellular trafficking/cytoskeleton remodeling, rather than a single linear pathway. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0061512","count":3},{"id":"GO:0000387","count":2}]},{"hash":"521959999276173056","title":"B cell maturation and antibody production","description":"The top GO terms cluster around adaptive immune processes, especially B cell development (germinal center formation), immunoglobulin production, and negative regulation of B cell proliferation, with related innate immune response and antiviral defense terms also present. Despite a few outliers (oocyte development, motor neuron apoptosis), the dominant theme is B cell\u2013driven humoral immunity and germinal center dynamics.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048255","count":2},{"id":"GO:0048599","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0002377","count":2},{"id":"GO:0030889","count":2}]},{"hash":"591952607566781327","title":"PDGF-PI3K Signaling and Immune/Coagulation Modulation","description":"This cluster centers on PDGF receptor signaling and PI3K/AKT pathways, with additional links to mucosal immune responses, complement regulation, coagulation, and apoptotic signaling, suggesting a cohesive theme of growth-factor\u2013driven signaling connected to immune and vascular/coagulation processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010765","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0048008","count":3},{"id":"GO:0032703","count":2},{"id":"GO:0051897","count":2}]},{"hash":"1381400529458199110","title":"Neural development and synapse formation","description":"The terms cluster around brain and nervous system development, corticospinal tract morphogenesis, radial glial differentiation, sensory perception, and synaptic assembly/transmission (including glutamatergic signaling). This points to a cohesive program of neural development and synapse formation in the brain. The absence of network edges does not diminish the thematic alignment to neural development and synaptogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":7},{"id":"GO:0021957","count":5},{"id":"GO:0007605","count":5},{"id":"GO:0072137","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1169963025045735238","title":"Vertebrate Development and Tissue Morphogenesis","description":"The cluster is enriched for diverse vertebrate development terms, including spinal cord development, cartilage morphogenesis, endocrine system development, seminiferous tubule development, and hemopoiesis, suggesting a broad role in tissue formation and organismal development. Additional GO terms for intracellular signaling and mRNA splicing indicate regulatory processes that drive differentiation and morphogenesis, rather than a single linear pathway. The absence of connections among proteins implies these proteins contribute to multiple developmental programs, supporting a general developmental/morphogenesis theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0030097","count":2}]},{"hash":"378036508241968419","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0008333","count":2},{"id":"GO:0045022","count":2},{"id":"GO:0000465","count":2},{"id":"GO:0034499","count":2}]},{"hash":"2052276582471101196","title":"Unknown","description":"The top GO terms span brain development, immune processes, apoptosis, and cell cycle with no single dominant shared function, making it unclear what unified role ties these proteins together. Therefore, a specific label isn\u2019t justifiable.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0035234","count":3},{"id":"GO:0002377","count":3}]},{"hash":"1452112702557403445","title":"Ubiquitin-Dependent Antiviral Innate Immunity","description":"The cluster is dominated by ubiquitin-dependent protein catabolic processes and defense/innate immune responses to viruses, suggesting proteins linked to proteostasis that intersect antiviral signaling. The presence of TNF signaling and apoptosis regulation supports an immune-regulatory role, while histone catabolic and ERAD-related terms indicate broader involvement in protein turnover and chromatin dynamics during immune responses. Overall, the proteins likely function together in ubiquitin-mediated degradation pathways that coordinate antiviral defense.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0051607","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0042981","count":11},{"id":"GO:0009048","count":11}]},{"hash":"114151008753623698","title":"ER-Golgi trafficking and skin development","description":"The strongest terms point to vesicle transport between the ER and Golgi, i.e., a secretory/trafficking role, while pigmentation and skin development suggest functions related to pigment formation and epidermal differentiation. The remaining terms (GTPase regulation, autophosphorylation, cell cycle/proliferation) likely reflect regulatory modulation of trafficking and development in proliferative skin contexts. Together, these imply a cluster centered on secretory pathway activity with skin-pigmentation links, rather than a single canonical pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006890","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0043473","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0098907","count":5}]},{"hash":"905166667495253934","title":"Gene Regulation and Development","description":"This cluster shows enrichment for regulatory processes (transcriptional regulation, NF-kappaB activity) alongside developmental and immune-related terms (neuron development, placenta morphogenesis, innate immune response). The proteins appear to be broadly involved in controlling gene expression with impacts on development and immunity, rather than a single specific pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0048666","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0070562","count":2},{"id":"GO:1901536","count":2}]},{"hash":"1901003329287144402","title":"Developmental differentiation and gene expression control","description":"This cluster shows enrichment for differentiation processes (oligodendrocyte and fat cell differentiation) and cell migration, alongside core gene expression regulation terms (DNA-templated transcription and translation initiation). The presence of telomere maintenance/capping-related terms hints at broader proliferation-associated regulation during development. Overall, it points to a theme of coordinating differentiation with gene expression machinery, rather than a single precise pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0048709","count":4},{"id":"GO:0016477","count":4}]},{"hash":"608050040601925743","title":"Diverse Substrate Transmembrane Transporters","description":"These proteins cluster around transmembrane transport functions across membranes for a wide range of substrates\u2014ions (sodium, potassium), sugars (galactose, arabinose), vitamins, nitrate, sialic acid, xenobiotics, and even neurotransmitter loading into synaptic vesicles\u2014indicating a cohesive role as diverse membrane transporters rather than enzymes or structural partners.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0071805","count":3}]},{"hash":"2210264947992844993","title":"Neuronal Synaptic Signaling and Drug Response","description":"The cluster centers on neural communication and sensory/drug-evoked responses, with strong representation of GABA signaling, excitatory postsynaptic potentials, sensory processing, startle responses, conditioned taste aversion, and responses to cocaine, insecticides, and amyloid-beta. This points to coordinated synaptic signaling and behaviorally relevant responses to stimuli and drugs; the acrosome reaction term may reflect shared exocytosis machinery but does not override the neural theme.","confidence":"High","size":20,"edges":108,"triangles":244,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":18},{"id":"GO:0007214","count":18},{"id":"GO:0060079","count":18},{"id":"GO:0050893","count":17},{"id":"GO:0007340","count":17}]},{"hash":"138701510431572478","title":"Embryonic Development and Morphogenesis","description":"These terms cluster around embryonic development, differentiation, and morphogenesis across multiple tissues (pancreas, placenta, cartilage, heart cushion EMT, trophoblast, left-right patterning). The dominant theme is developmental processes and organogenesis, with a few incidental terms like proteolysis or immune pathways. Confidence: High","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":8},{"id":"GO:0060806","count":7},{"id":"GO:0060536","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003198","count":7}]},{"hash":"1764308740755020642","title":"GPCR Signaling and Calcium Release in Sensory Tissues","description":"The cluster is enriched for GO terms tied to GPCR signaling (internalization, GTPase activity regulation), neuropeptide signaling, pain perception, and phototransduction, plus calcium ion release regulation. Together these point to a theme of GPCR-driven calcium signaling in sensory or neural contexts, with inflammatory modulators (lipopolysaccharide, prostaglandin) contributing to the signaling milieu. Some development-related terms may reflect shared signaling components, but the core motif is GPCR-mediated calcium dynamics in sensory processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051281","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0007603","count":5},{"id":"GO:0002031","count":5},{"id":"GO:0032496","count":5}]},{"hash":"906903868367064491","title":"Mitotic spindle assembly and cell polarity regulation","description":"The top GO terms are dominated by mitosis-related processes\u2014mitotic spindle assembly and mitotic cell cycle\u2014along with establishment or maintenance of cell polarity regulating cell shape. This points to a cohesive theme around chromosome segregation, spindle organization, and polarity cues during cell division. A few other terms (xenobiotic response, retinoic acid signaling) are present but appear secondary; overall the cluster centers on mitotic mechanics and polarity. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0071963","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0035690","count":2},{"id":"GO:0048384","count":2}]},{"hash":"1078453744749755824","title":"Mechanotransduction and angiogenesis regulation cluster","description":"This cluster shows enrichment in cytokine signaling, responses to mechanical stimuli, and extracellular matrix organization, along with Wnt signaling and modulation of endothelial behavior. The mix of positive/negative regulation of IL-8, endothelial migration, and angiogenesis, plus sarcomere and collagen-related terms, suggests a module coordinating mechanical cues, inflammation, and vascular remodeling, including suppression of new vessel formation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019221","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0016055","count":4},{"id":"GO:0048549","count":4}]},{"hash":"1188453191358912983","title":"Neural Synaptic Plasticity and Behavior","description":"This cluster centers on neuronal synapse modulation and plasticity (dendritic spine morphogenesis, synapse structural plasticity, long-term synaptic depression, regulation of excitatory postsynaptic potential) and on associated neural behaviors (social behavior, vocalization, sensory perception of sound). The presence of ephrin receptor signaling further supports trans-synaptic signaling roles in plasticity. Together, these terms describe a group of proteins linked to activity-dependent synaptic changes and related behaviors.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":4},{"id":"GO:0035176","count":4},{"id":"GO:0060997","count":4},{"id":"GO:2000463","count":3},{"id":"GO:0051835","count":3}]},{"hash":"671412406114362690","title":"Developmental Regulation and Stem Cell Maintenance","description":"This cluster gathers genes linked to development across multiple tissues (eye lens, inner ear, heart, placenta) and to stem cell maintenance, alongside transcriptional control and regulatory signaling (notably Wnt). The terms point to a general developmental regulatory theme rather than a single tissue-specific function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0002088","count":2},{"id":"GO:0001890","count":2},{"id":"GO:0048839","count":2},{"id":"GO:0007507","count":2}]},{"hash":"680782575763914792","title":"ECM remodeling and basement membrane formation","description":"The top GO terms cluster around collagen processing and organization (collagen fibril organization, collagen catabolic process), basement membrane development, and cell\u2013substrate adhesion, alongside endothelial proliferation and blood coagulation. This points to extracellular matrix remodeling and basement membrane assembly/maintenance with vascular remodeling, rather than a single tight signaling pathway. Immune signaling terms (IL-4 production, B cell receptor signaling) appear secondary to the ECM-focused themes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001938","count":3},{"id":"GO:0030574","count":2},{"id":"GO:0010811","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0032836","count":2}]},{"hash":"1741654360541008025","title":"Brain Development and Synaptic Connectivity","description":"This cluster is driven by neural development terms (hippocampus and substantia nigra development, in utero development) and neural signaling (excitatory postsynaptic potential, motor neuron axon guidance), plus cell-matrix adhesion indicating connectivity. While some terms are broader (DNA replication regulation, proteasomal degradation), the core theme centers on brain development and synaptic connectivity.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006349","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0007160","count":2}]},{"hash":"1784182246316091251","title":"Muscle and heart development regulators","description":"This cluster is enriched for musculoskeletal and cardiac development terms (embryonic skeletal system, myotube development, heart development) and for signaling pathway regulation (negative regulation of BMP and TGF-beta signaling), pointing to proteins coordinating muscle differentiation and heart formation, possibly via transcriptional control and metabolic adaptation. Some terms appear incidental or pleiotropic (olfactory learning, intestinal epithelial differentiation) but do not disrupt the main theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048706","count":2},{"id":"GO:0060575","count":2},{"id":"GO:1903715","count":2},{"id":"GO:0030512","count":2},{"id":"GO:0030514","count":2}]},{"hash":"1837119191785728068","title":"Developmental PI3K/ERK Signaling","description":"This cluster centers on growth factor\u2013driven developmental signaling, with enrichment for positive regulation of ERK1/2 cascade and PI3K activity, plus heart and multicellular development terms (VEGF signaling). Some terms appear less directly related or are obsolete, but overall the proteins seem tied to signaling pathways governing development and organ formation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0038091","count":3},{"id":"GO:0007037","count":3},{"id":"GO:0070640","count":3}]},{"hash":"1220965075858407267","title":"Rho-Driven Actin Remodeling and Projections","description":"This cluster centers on actin cytoskeleton dynamics and Rho signaling, with GO terms for actin filament formation, crosslinking, and movement, plus processes involving cellular projections (neuronal projections, dendritic cell differentiation) and adhesion. The inclusion of sarcomere organization and megakaryocyte development further supports a theme of cytoskeletal remodeling across cell types, rather than a single, narrow pathway. Confidence: High","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0051639","count":3},{"id":"GO:2001200","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0035855","count":2}]},{"hash":"575641412176111668","title":"Neurotransmitter metabolism and transport","description":"The proteins show GO terms centered on dopamine catabolism, serotonin uptake, glycine secretion for neurotransmission, and amino acid transport, plus clues about extracellular signaling regulation and glial growth. This suggests a coherent theme around neuronal signaling and neurotransmitter handling, despite some outliers.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042420","count":3},{"id":"GO:1900116","count":2},{"id":"GO:0009405","count":2},{"id":"GO:0044179","count":2},{"id":"GO:0006777","count":2}]},{"hash":"945515898050599246","title":"Multitissue Development and Morphogenesis","description":"Top GO terms point to developmental and morphogenetic processes across multiple tissues (mesoderm, cartilage, hair follicle, roof of the mouth, pancreas, trophoblast). Some entries reflect general cellular machinery (ribosomal export, splicing, DNA replication), but the dominant signal is tissue morphogenesis and development.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007498","count":20},{"id":"GO:0031069","count":20},{"id":"GO:0060021","count":20},{"id":"GO:0000055","count":20},{"id":"GO:0000398","count":20}]},{"hash":"823052401289678654","title":"Immune signaling regulation and secretory organelle organization","description":"The top GO terms point to immune regulation (negative regulation of T cell receptor signaling, negative regulation of IL-2 production, and positive regulation of cytokine production in inflammatory response) and defense against protozoa, together with cellular organization of the secretory pathway (endoplasmic reticulum and Golgi). This suggests a cluster of proteins that modulate immune signaling while coordinating ER/Golgi organization and related protein interactions (e.g., oligomerization). ","confidence":"Medium","size":19,"edges":58,"triangles":53,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":10},{"id":"GO:1903077","count":7},{"id":"GO:0007029","count":7},{"id":"GO:0071158","count":7},{"id":"GO:1900017","count":7}]},{"hash":"1997788389181530078","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by ribosome assembly and translation-related processes: ribosome biogenesis, formation of translation preinitiation complex, ribosomal large subunit biogenesis, translation, translation reinitiation, and tRNA processing. While a couple of terms reference transcription initiation and brain development, they appear as minor/background signals. Overall, the cluster behavior aligns with ribosome construction and protein synthesis machinery, justifying this label.","confidence":"High","size":19,"edges":111,"triangles":331,"max_degree":16,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0002188","count":2}]},{"hash":"957756263346575700","title":"Notch-driven vertebrate organogenesis and neural development","description":"Based on the top GO terms, the cluster centers on diverse vertebrate organ development processes (nephron morphogenesis, heart/atrial formation, bronchiole and retina development) and neural/glial differentiation (glial fate commitment, astrocyte differentiation). The Notch signaling pathway is prominent, suggesting these proteins coordinate developmental patterning and lineage specification. Transcription by RNA polymerase II ties these processes to active gene regulation, indicating a coherent developmental program rather than a single pathway. ","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":17},{"id":"GO:0007219","count":14},{"id":"GO:0072282","count":14},{"id":"GO:0009410","count":14},{"id":"GO:0003062","count":14}]},{"hash":"351303816102069396","title":"Neuronal projection and dendrite morphogenesis","description":"The terms converge on neuronal growth and architecture, including axon extension, neuron projection development, and dendrite morphogenesis, along with cytoskeletal dynamics (microtubule polymerization and sliding) and synaptic protein localization. Calcium signaling regulation and metabolic aspects like mitochondrial membrane potential also align with neuronal maturation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045773","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0050848","count":3},{"id":"GO:0031116","count":3},{"id":"GO:1901216","count":3}]},{"hash":"376738171249532005","title":"Light-regulated transcription and circadian control","description":"The prominent GO terms point to DNA-templated transcription, circadian rhythm regulation, and responses to light stimuli (red and far-red), suggesting a core role in light-driven transcriptional control and circadian timing. Additional associations with histone deacetylation, hormone biosynthesis, and xenobiotic response imply broader regulatory potential, but the strongest signal is transcriptional regulation tied to light signaling and circadian processes.","confidence":"High","size":19,"edges":168,"triangles":919,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":18},{"id":"GO:0070932","count":17},{"id":"GO:1903715","count":16},{"id":"GO:0009410","count":15},{"id":"GO:0046886","count":15}]},{"hash":"632503859536857226","title":"Neuronal Development and Synapse Assembly","description":"The cluster centers on neural development and synaptic organization: axon guidance, positive regulation of synapse assembly, and PSD-95 clustering, with neural tube closure and prepulse inhibition indicating broader CNS development and function. Extra terms like extracellular exosome assembly and regulation of cell migration hint at vesicle trafficking and movement processes tied to developing neurons, while blood coagulation is less directly related. Overall, the dominant signal points to neural development and synaptic maturation.","confidence":"Medium","size":19,"edges":24,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0050927","count":3},{"id":"GO:0014068","count":3}]},{"hash":"253619921117994837","title":"Immune activation and signaling","description":"This cluster is dominated by GO terms related to immune system activity, including innate immune response, adaptive immune response, B cell receptor signaling, NK cell cytokine production, and signaling pathway regulation (PI3K/AKT, CCR7). The presence of a few non-immune terms (melanocyte migration, spermatid development) appears incidental, but the core theme is immune activation and intercellular signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010765","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0010641","count":3}]},{"hash":"121551615778893254","title":"Metabolic and stress-response signaling","description":"This cluster centers on metabolic processes (prostaglandin biosynthesis, aromatic amino acid metabolism, nitrogen utilization) and diverse stress responses (starvation, ethanol, lithium), with regulators of signaling pathways (ERK cascade, TNF production). Together, they suggest a module of proteins coordinating metabolic stress with inflammatory and signaling responses, rather than a single narrow function.","confidence":"Medium","size":19,"edges":63,"triangles":127,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":9},{"id":"GO:0042594","count":8},{"id":"GO:0060316","count":8},{"id":"GO:0045471","count":7},{"id":"GO:0009072","count":7}]},{"hash":"785004768189941562","title":"Unknown","description":"The top GO terms include pain perception, temperature-related responses, learning, immune function, blood pressure regulation, and T cell differentiation, with no clear common function tying these together. The terms are heterogeneous and include obsolete entries, suggesting a mixed or non-cohesive set of roles rather than a single biological theme.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0008542","count":6},{"id":"GO:0006955","count":6}]},{"hash":"241362134097990007","title":"Growth signaling and transcriptional regulation","description":"The top GO terms point to signaling that promotes growth (multicellular organism growth, response to growth hormone, positive regulation of GTPase activity) and to gene expression control (DNA-templated transcription, positive regulation of transcription by transcription factor localization). Additional terms like cell migration and epithelial polarity suggest downstream developmental processes linked to growth signaling and transcriptional programs, making the cluster cohesive around growth-related signaling and transcription regulation rather than a single pathway. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007568","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0097284","count":2},{"id":"GO:0033028","count":2}]},{"hash":"972874586216072255","title":"Dopaminergic Signaling and Visual Perception","description":"Top GO terms are dominated by neural and sensory processes: dopaminergic synaptic transmission, visual perception and learning, cocaine-related behavior, and related signaling (ERK cascade). A few terms touch on immune or cardiovascular processes, but the core signal points to CNS signaling and vision, justifying this label.","confidence":"Medium","size":19,"edges":21,"triangles":2,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0048148","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0071380","count":8},{"id":"GO:0007507","count":8}]},{"hash":"800505675101983555","title":"Ubiquitin-dependent proteolysis and innate immunity","description":"The top GO terms cluster around ubiquitin-mediated protein turnover (ubiquitin-dependent proteolysis, ERAD, K63-linked ubiquitination, autoubiquitination) and innate immune responses (innate immune response, defense against virus, MHC I biosynthesis). While some terms touch on vitamin D signaling and neuronal/cardiac processes, the prominent signal is ubiquitin-driven regulation linked to immune defense and antigen processing, suggesting a coherent module of ubiquitin-related proteostasis and antiviral responses.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0045087","count":12},{"id":"GO:0033280","count":12},{"id":"GO:0060386","count":11},{"id":"GO:0051607","count":11}]},{"hash":"2135634472715318648","title":"Unknown","description":"The proteins in this cluster span diverse functions, including nervous system development (paranodal junction assembly, collateral sprouting, mechanosensory detection), immune signaling (T cell costimulation), heart development, host-symbiont interactions, and general processes like cell adhesion and proteolysis. There isn\u2019t a clear, single unifying theme among the top GO terms, so a cohesive functional label is not evident.","confidence":"","size":19,"edges":11,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":7},{"id":"GO:0009636","count":6},{"id":"GO:0031295","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0050910","count":5}]},{"hash":"1024368616841497956","title":"Immune Activation and Inflammatory Signaling","description":"The cluster\u2019s top GO terms center on immune and inflammatory processes (inflammatory response, response to lipopolysaccharide, immunoglobulin production) and immune-related signaling (positive regulation of STAT phosphorylation), with supporting links to cell adhesion and development. This suggests a cohesive group of proteins involved in activating immune responses and associated signaling, with some overlap into developmental/vascular contexts via angiogenesis-related regulation and adhesion.","confidence":"Medium","size":19,"edges":96,"triangles":181,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007275","count":13},{"id":"GO:0006954","count":13},{"id":"GO:0071260","count":10},{"id":"GO:1903588","count":10},{"id":"GO:0032496","count":10}]},{"hash":"1196457528656530390","title":"Bacterial fatty acid and menaquinone biosynthesis","description":"The top GO terms cluster around lipid metabolism and cell envelope biosynthesis (very long-chain and medium-chain fatty-acyl-CoA metabolic processes, fatty acid biosynthetic process, lipoteichoic acid biosynthetic process) and vitamin K2 (menaquinone) biosynthesis, with additional signals of bacterial energy metabolism (pyruvate fermentation to acetate). This points to a cohesive theme of bacterial lipid and quinone biosynthesis pathways, despite a few outliers likely due to annotation noise. ","confidence":"Medium","size":19,"edges":40,"triangles":14,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0019654","count":1},{"id":"GO:0000038","count":1},{"id":"GO:0070395","count":1},{"id":"GO:0010214","count":1},{"id":"GO:0090410","count":1}]},{"hash":"1203474180669662100","title":"Cardiac morphogenesis and heart development","description":"The cluster is dominated by GO terms related to heart formation and structure, including coronary artery morphogenesis, atrioventricular node development, endocardial cushion/morphogenesis and ventricle morphogenesis, as well as pericardium morphogenesis. Additional terms point to signaling and transcriptional regulation (Notch, Wnt) involved in cardiac development, and cell adhesion/migration relevant to endocardial cushions, supporting a cohesive cardiac development theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060982","count":17},{"id":"GO:0007157","count":17},{"id":"GO:0003273","count":17},{"id":"GO:0044332","count":17},{"id":"GO:0003162","count":16}]},{"hash":"348435238280165973","title":"Multicellular development and tissue differentiation","description":"The top GO terms span broad multicellular development and tissue-specific differentiation (bone, skin, lens) across several tissues, with additional emphasis on regulation of signaling pathways (ephrin signaling, GTPase activity) and synaptic-associated processes, suggesting a cluster of proteins involved in developmental signaling and tissue specification rather than a single pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:1900383","count":5},{"id":"GO:1901187","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007568","count":4}]},{"hash":"1107092627638270795","title":"Deubiquitination and protein homeostasis","description":"This cluster is strongly enriched for deubiquitination terms (K6- and K29-linked, plus general deubiquitination) and ERAD-related protein quality control, with supporting signals from DNA repair, spindle/mitosis, and signaling pathways. The dominant theme is ubiquitin-mediated regulation of protein turnover and cellular stress responses, making this label representative of the cluster\u2019s function.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0034140","count":6},{"id":"GO:0000226","count":6},{"id":"GO:0008625","count":5},{"id":"GO:0016579","count":5},{"id":"GO:1904378","count":5}]},{"hash":"679214247335117309","title":"Neural development and cytoskeletal signaling","description":"The cluster shows strong signals for nervous system and brain development and for synaptic vesicle exocytosis, indicating neuronal function. It also features cytoskeletal and adhesion-related processes (Rho signaling, stress fiber assembly, cell spreading) and some cell division terms (mitotic cell cycle, cell division), suggesting coordinated neuronal development with cytoskeletal remodeling and growth-related dynamics. Overall, the set points to proteins involved in neural development coupled to cytoskeletal regulation.","confidence":"Medium","size":19,"edges":19,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:2000300","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0031384","count":5}]},{"hash":"1488773679510353383","title":"Embryonic organ and craniofacial morphogenesis","description":"Proteins in this cluster are enriched for morphogenesis terms affecting multiple developing structures (craniofacial features like face and palate, cardiac outflow tract and ventricular septum, ocular structures like cornea and vision, and neural/left-right patterning). The diverse but related GO terms point to a general role in developmental morphogenesis rather than a single pathway, justifying a label centered on embryonic organ and craniofacial morphogenesis.","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0060412","count":2},{"id":"GO:0060577","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0007601","count":2}]},{"hash":"506430546041125910","title":"Neuronal development and synaptic plasticity","description":"The cluster is dominated by GO terms related to neurons: dendrite self-avoidance, long-term synaptic plasticity regulation, potassium channel clustering (affecting neuronal excitability), and MAPK signaling in neural contexts, along with behavior. While a couple terms appear non-neuronal (vagina development, muscle myosin assembly), the core signal centers on neural development and function.","confidence":"High","size":19,"edges":85,"triangles":158,"max_degree":16,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:1902955","count":9},{"id":"GO:0048671","count":9},{"id":"GO:0070593","count":9},{"id":"GO:0060068","count":9},{"id":"GO:0045163","count":9}]},{"hash":"2080918169055485665","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0034477","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0030223","count":1},{"id":"GO:0006397","count":1}]},{"hash":"1883860959701434444","title":"Muscle sarcomere assembly and contraction","description":"Top GO terms cluster around sarcomere organization, muscle contraction, actin filament polymerization, and skeletal myofibril assembly, with supportive hints of heart development and cytoskeletal regulation. This points to proteins involved in assembling and enabling the contractile apparatus of muscle fibers (skeletal and cardiac) and associated cell adhesion. Some synaptic terms may reflect neuromuscular junction or signaling-related cytoskeletal dynamics, but the core theme is muscle fiber assembly and contractile function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045214","count":3},{"id":"GO:0006936","count":3},{"id":"GO:0030041","count":3},{"id":"GO:0014866","count":3},{"id":"GO:0035023","count":3}]},{"hash":"170690569668475966","title":"Ubiquitin-Dependent Proteolysis and Innate Immunity","description":"This cluster is driven by ubiquitination-related processes (ubiquitin-dependent protein catabolism, various ubiquitination forms, ERAD) with links to innate immunity and antiviral defense, plus histone ubiquitination, indicating ubiquitin-mediated protein turnover coupled to immune signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0051865","count":7},{"id":"GO:0036205","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":7}]},{"hash":"1677416897792837717","title":"Ubiquitin-Dependent Proteolysis and Innate Immunity","description":"The cluster shows strong enrichment for ubiquitin-mediated protein catabolism and innate immune functions (innate immune response, defense against virus, MHC class I biosynthesis), suggesting a core theme around ubiquitin-dependent protein turnover linked to immune defense. While also listing development- and synapse-related terms, the dominant signals point to proteolysis via ubiquitination coordinating immune-related processes.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0051865","count":9},{"id":"GO:0030433","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0051607","count":8}]},{"hash":"1761906586175167066","title":"Diverse membrane transporters","description":"The GO terms are dominated by various transmembrane transport activities across multiple substrates (xenobiotic, vitamin, sodium/potassium ions, carbohydrate, nitrate, sialic acid, galactose, etc.), suggesting a cluster of proteins that function broadly as membrane transporters with diverse cargoes rather than a single, specific substrate. The lack of edges does not change this functional theme; it reflects the annotation pattern rather than direct interactions.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0008542","count":3}]},{"hash":"2185100037780158700","title":"Organ morphogenesis during development","description":"The GO terms point to morphogenesis across many organs (palate, heart, lung, pericardium, vessels, kidney tubules, ear, neurons, immune tissue) and related developmental processes, suggesting a cluster centered on developmental morphogenesis. A few terms on endocytosis regulation appear, but the dominant theme remains organogenesis.","confidence":"Medium","size":19,"edges":41,"triangles":57,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1990134","count":18},{"id":"GO:0061444","count":17},{"id":"GO:0060488","count":17},{"id":"GO:0003344","count":17},{"id":"GO:0001974","count":17}]},{"hash":"632839340419372044","title":"Synaptic Vesicle Trafficking and Neurotransmitter Secretion","description":"The top GO terms are dominated by neuronal secretory processes and synaptic function, including ER-to-Golgi vesicle transport, dense core granule maturation, monoamine transport, regulation of neurotransmitter secretion, and dendritic spine maintenance, along with long-term synaptic depression. This points to a core theme of vesicle trafficking and synaptic signaling in neurons, with some peripheral terms reflecting secretory pathways in other cell types. Overall, the cluster appears to center on neuronal secretion and synaptic regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0002175","count":3},{"id":"GO:0050796","count":3},{"id":"GO:0001922","count":3}]},{"hash":"728819415275021279","title":"Eye and organ morphogenesis transcriptional regulation","description":"This cluster shows strong signals for eye development (camera-type eye development, embryonic eye morphogenesis) plus other organ morphogenesis terms (cerebellum, hypothalamus, lung, skeletal muscle), all linked by transcriptional regulation by RNA polymerase II, suggesting a shared developmental transcription program across tissues with an ocular emphasis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0043010","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0048048","count":7},{"id":"GO:0007519","count":7}]},{"hash":"1283943018090374287","title":"Vertebrate craniofacial and pharyngeal development","description":"This cluster is dominated by GO terms related to craniofacial formation and derivatives, including palate development, odontogenesis, neural crest migration, pharyngeal system development, and associated organs (inner ear, pituitary, outflow tract). The common theme ties together vertebrate craniofacial and pharyngeal organogenesis, with related neural crest and ectodermal contributions.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":7},{"id":"GO:0007498","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0001755","count":5}]},{"hash":"445874391000395655","title":"Ubiquitin-Mediated Innate Antiviral Defense","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic process and innate immune/virus defense, suggesting the proteins function in tagging and degrading regulators during antiviral responses, with some regulatory epigenetic/gene-expression links; however, a few terms (dosage compensation, vitamin D response) appear ancillary to the main theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0045087","count":8},{"id":"GO:0051607","count":8},{"id":"GO:0033280","count":7},{"id":"GO:1902187","count":6}]},{"hash":"937609225130926200","title":"T Cell Activation and Immune Signaling","description":"The dominant GO terms point to T cell activation, T cell receptor signaling, innate immune responses, apoptosis execution, and key signaling cascades (ERK, PI3K/AKT). These collectively suggest a cluster centered on immune cell activation and signaling, particularly T cells, with some peripheral terms (B cell proliferation, ectodomain proteolysis) that still align with immune regulation. Some outliers (forebrain development, response to food) exist but don\u2019t erase the central theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006924","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051044","count":2},{"id":"GO:0097194","count":2}]},{"hash":"463526909909471339","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around diverse developmental and morphogenetic processes (mesoderm, cartilage, hair follicle, placenta differentiation, left-right patterning), indicating a general theme of embryonic tissue morphogenesis rather than a single specific function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":18},{"id":"GO:0060536","count":18},{"id":"GO:0060707","count":18},{"id":"GO:0034396","count":18},{"id":"GO:0007498","count":18}]},{"hash":"1592533146462929196","title":"Developmental signaling and morphogenesis","description":"The top GO terms point to broad developmental roles, including multicellular organism development, morphogenesis across various tissues (heart outflow tract, retinal vasculature, pancreatic beta cell development, kidney), and signaling pathway regulation (Wnt, Hedgehog/Smoothened) plus ECM-cell signaling. Although immune-related terms appear, the dominant pattern is development and tissue morphogenesis driven by core signaling pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0035426","count":2},{"id":"GO:0003151","count":2}]},{"hash":"342051587499814033","title":"Translation machinery and ribosome biogenesis","description":"The top GO terms are dominated by translation-related processes (initiation, elongation, termination, and cytoplasmic translation) and ribosome biogenesis, pointing to a cohesive module of protein synthesis and ribosome assembly/regulation. Auxiliary terms like mRNA decay and glial proliferation are less central but may reflect related RNA turnover or cell context, while the core signal is clearly translation. ","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":17},{"id":"GO:0046677","count":6},{"id":"GO:0042254","count":3},{"id":"GO:0045903","count":3},{"id":"GO:0000288","count":3}]},{"hash":"167623631205454447","title":"Chromatin organization and transcriptional regulation","description":"The cluster is enriched for chromatin-related processes: negative regulation of transcription by RNA polymerase II; nucleosome assembly; histone methylation regulation; rDNA heterochromatin formation. These point to a shared function in chromatin structure and control of gene expression. A few terms about Rho signaling and axonogenesis appear but are secondary to the dominant chromatin/transcription theme.","confidence":"Medium","size":18,"edges":17,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0008285","count":3},{"id":"GO:0061188","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0050771","count":3}]},{"hash":"288188152092588365","title":"Cardiac calcium handling and contraction","description":"GO terms center on heart-specific calcium signaling and contraction, including regulation of voltage-gated calcium channels, SR-mediated calcium release, and cardiac muscle contraction, with heart development supporting a cardiac context. Some terms (e.g., cytochrome c release) are less central but do not override the dominant theme of calcium handling in cardiac muscle.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0090200","count":2},{"id":"GO:0060315","count":2},{"id":"GO:0007205","count":2},{"id":"GO:1901387","count":2}]},{"hash":"1687313908713503519","title":"Dopaminergic neuron development and redox regulation","description":"This cluster combines neural development signals (substantia nigra development, dopamine metabolism, neural precursor proliferation) with redox-related processes (oxidation-reduction, redox homeostasis, ER stress). The overlap suggests proteins involved in dopaminergic neuron formation and maturation that are coordinated with cellular redox balance, with some stress-response terms reflecting adaptive responses to neural stressors (ethanol, fungicide). ","confidence":"Medium","size":18,"edges":66,"triangles":122,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0045454","count":6},{"id":"GO:0034976","count":6},{"id":"GO:1903206","count":6},{"id":"GO:0008283","count":5}]},{"hash":"1525353929207454687","title":"Bone development and remodeling","description":"The dominant terms include intramembranous ossification, bone resorption, and collagen catabolic process, indicating a core theme of skeletal development and extracellular matrix remodeling. There are also signals related to Wnt pathway regulation and thyroid hormone response, which commonly modulate bone biology and development. Some terms reflect broader developmental processes (neural precursor proliferation, decidualization, lung branching), likely reflecting shared regulatory networks but not exclusive to bone. Overall, the cluster seems best labeled as bone development and remodeling.","confidence":"Medium","size":18,"edges":134,"triangles":593,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0050790","count":18},{"id":"GO:2000179","count":18},{"id":"GO:0001957","count":18},{"id":"GO:0035593","count":18},{"id":"GO:0045453","count":18}]},{"hash":"1134763135245148781","title":"Unknown","description":"The terms are spread across neuronal development, chromatin remodeling, apoptosis, T cell signaling, mRNA processing, calcium signaling, and developmental processes in mammary gland and ovary. Although a couple of calcium-related terms appear, there is no cohesive single function or pathway linking all terms, so a specific label isn\u2019t supported.","confidence":"","size":18,"edges":12,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010976","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0006378","count":2}]},{"hash":"1991102924172347887","title":"Multitissue Development and Secretory Calcium Signaling","description":"The proteins are associated with development across multiple tissues (lens, skin, aorta, coronary vasculature, mesoderm) and with secretory and calcium signaling processes, suggesting a broad embryonic/organ development theme with linked secretion and calcium regulation. Although terms like visual perception and fear behavior appear, the dominant pattern is multi-tissue development coupled with secretory/calcium signaling.","confidence":"Medium","size":18,"edges":26,"triangles":12,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0002088","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0046541","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0043588","count":2}]},{"hash":"1432883356682062322","title":"Embryonic neural and cardiac morphogenesis","description":"This cluster\u2019s GO terms converge on developmental processes across neural and cardiac lineages, including neural development (dendrite self-avoidance, neuroblast division), heart/muscle formation (pulmonary myocardium development, striated muscle thick filament assembly), and morphogenetic signaling (Smoothened pathway, embryonic cranial skeleton morphogenesis). VEGF/PDGF signaling relates to developmental proliferation, and potassium channel clustering ties to neural maturation. Together, they point to embryonic tissue morphogenesis and organogenesis, especially in neural and cardiac contexts.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048671","count":18},{"id":"GO:0070593","count":18},{"id":"GO:0045163","count":18},{"id":"GO:0038091","count":18},{"id":"GO:0048468","count":18}]},{"hash":"2225804197086184831","title":"Renin-Angiotensin\u2013Mediated Hormone Secretion and Blood Pressure Regulation","description":"The cluster is dominated by GO terms related to the renin-angiotensin system, blood pressure regulation, and hormone secretion, suggesting a coherent endocrine-vascular regulatory theme; a few terms (like operant conditioning and T cell differentiation) appear peripheral but do not negate the core pattern.","confidence":"Medium","size":18,"edges":42,"triangles":42,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":18},{"id":"GO:0035625","count":18},{"id":"GO:0001991","count":18},{"id":"GO:0002300","count":18},{"id":"GO:0003093","count":18}]},{"hash":"867709068102104690","title":"Cell Proliferation and Growth Signaling Regulators","description":"This cluster centers on regulation of cell proliferation and growth signaling, as shown by the prominent GO terms for positive regulation of cell population proliferation and cell population proliferation, along with various signaling-related terms (GTPase activity, GPCR/EGFR signaling, cAMP pathways). While there are some tissue- or process-specific terms (retina development, glomerular filtration, renin-angiotensin, T cell differentiation), the shared theme across members appears to be modulation of growth and signaling pathways rather than a single tissue function.","confidence":"Medium","size":18,"edges":132,"triangles":539,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008284","count":18},{"id":"GO:0008283","count":18},{"id":"GO:0043547","count":18},{"id":"GO:0060041","count":18},{"id":"GO:0043950","count":17}]},{"hash":"1018284345338477529","title":"Mitotic Spindle Assembly and Microtubule Dynamics","description":"The cluster is dominated by GO terms related to centrosome and spindle separation, plus-end microtubule dynamics, and actomyosin ring assembly, indicating a cohesive module of proteins governing mitosis and cytoskeletal regulation, with some adhesion signaling components. This points to functions in spindle formation, chromosome segregation, and cytokinesis.","confidence":"High","size":18,"edges":94,"triangles":364,"max_degree":13,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007100","count":9},{"id":"GO:0000073","count":6},{"id":"GO:0001560","count":6},{"id":"GO:0070462","count":6},{"id":"GO:0000915","count":6}]},{"hash":"2222306940055055311","title":"RNA processing and translation machinery","description":"The cluster shows strong representation of mRNA splicing (spliceosome), mRNA processing, translation (initiation, preinitiation complex, reinitiation), and cytoplasmic stress granule localization, which together point to RNA metabolism and protein synthesis. Regulatory ncRNA-mediated gene silencing fits with RNA-based regulation as well. A few terms like DNA repair or Sertoli cell differentiation may be incidental or reflect broader roles of some proteins, but the dominant theme is RNA processing and translation.","confidence":"High","size":18,"edges":9,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":2},{"id":"GO:1903608","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0001731","count":2}]},{"hash":"2112806034357487781","title":"RNA Processing and miRNA Regulation","description":"This cluster is dominated by GO terms related to post-transcriptional control: regulation of mRNA stability during stress, mRNA splicing via spliceosome, mRNA catabolic processes, and positive regulation of miRNA-mediated gene silencing and miRNA catabolic regulation, as well as mRNA binding. These point to RNA metabolism and gene expression control at the RNA level. A couple of terms (pallium forebrain proliferation and carotene/MEP pathway) seem less directly connected and may reflect broader species-specific annotations or secondary roles. Overall, the main theme is RNA processing and post-transcriptional regulation under stress.","confidence":"Medium","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0010610","count":14},{"id":"GO:0000398","count":12},{"id":"GO:0090503","count":10},{"id":"GO:0022013","count":9},{"id":"GO:0006402","count":9}]},{"hash":"110221804675517501","title":"Immune Cell Development and Signaling","description":"The cluster\u2019s top GO terms are dominated by immune-related development and signaling processes (B cell affinity maturation, NK T cell differentiation, IL-4 production, IL-7 response), supported by general cellular processes like endocytosis and cell migration. While there are a couple broad developmental terms (heart development, synapse assembly), the recurring themes center on immune cell maturation and signaling, justifying an immune-focused label. Confidence: Medium","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0008286","count":5},{"id":"GO:0002344","count":5},{"id":"GO:0098761","count":5},{"id":"GO:0016477","count":5}]},{"hash":"2268667975631079399","title":"Diverse Development and Cell Division Functions","description":"The top GO terms cover spindle assembly (cell division) alongside multiple developmental differentiation processes (hair follicle morphogenesis, neuron differentiation, vulval and lateral root development, sperm DNA condensation). This suggests a mix of roles in development and some cell-cycle related activities, but no single coherent pathway encompasses all terms, so the cluster likely reflects diverse functions rather than a single function.","confidence":"Medium","size":18,"edges":17,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0045060","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0051312","count":1},{"id":"GO:0060850","count":1}]},{"hash":"1755104043670474601","title":"Xenobiotic and sugar transmembrane transporters","description":"The cluster is dominated by GO terms for transmembrane transport across the membrane, including xenobiotic, vitamin, and sugar transport, plus ion transport (potassium, sodium-dependent cation transport). This pattern points to a set of membrane transport proteins with diverse substrates, especially xenobiotics and carbohydrates, consistent with a transporter-focused cluster.","confidence":"High","size":18,"edges":31,"triangles":9,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":18},{"id":"GO:0035461","count":18},{"id":"GO:0071805","count":16},{"id":"GO:0042908","count":16},{"id":"GO:0042891","count":13}]},{"hash":"444309564134746395","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":134,"triangles":572,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007117","count":14},{"id":"GO:0001881","count":14},{"id":"GO:1905608","count":14},{"id":"GO:0050709","count":14},{"id":"GO:0035330","count":14}]},{"hash":"604502334457747380","title":"Dendrite and Synapse Development","description":"This cluster is dominated by GO terms related to neuronal development and synapse formation/remodeling, including dendrite development, regulation of synapse structural plasticity, GABAergic synaptic transmission, and filopodium dynamics. Trafficking-related terms (Golgi localization) and sensory development (cochlea morphogenesis) appear as broader developmental context, but the core theme centers on neurite outgrowth and synaptic assembly. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016358","count":5},{"id":"GO:0051835","count":5},{"id":"GO:0051683","count":5},{"id":"GO:0070830","count":5},{"id":"GO:0090103","count":5}]},{"hash":"1892847920989441728","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"This cluster centers on ubiquitin-dependent protein turnover and ubiquitination (including K63-linked ubiquitination and autoubiquitination), paired with innate immune functions such as defense against virus and TNF/NF-kB signaling. The presence of histone catabolic processes also suggests chromatin remodeling linked to immune regulation. Together, these terms indicate a theme of ubiquitin-mediated regulation of innate immune responses.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:1903265","count":10},{"id":"GO:0085020","count":9},{"id":"GO:0036205","count":9},{"id":"GO:0051607","count":9}]},{"hash":"1433331456206745345","title":"Leukocyte adhesion and immune signaling","description":"Based on top GO terms, the cluster centers on interactions between immune cells and defense: both homophilic/heterophilic cell adhesion and robust immune activity (immunoglobulin production, NK cell cytokine production, CCR7 signaling, macrophage regulation, defense against bacteria). The cardiac action potential and spermatid development terms appear peripheral, likely noise, but the dominant theme is leukocyte communication and immune response.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0086014","count":4},{"id":"GO:0002377","count":4},{"id":"GO:0002729","count":3}]},{"hash":"559010403492943046","title":"Embryonic organogenesis and morphogenesis","description":"The cluster centers on developmental processes across organs, including male gonad development, outflow tract (heart) morphogenesis, and embryonic hindlimb morphogenesis, plus cardiac muscle cell proliferation. The presence of regulatory terms like negative regulation of transcription by RNA polymerase II and negative regulation of miRNA processing supports a theme of coordinated gene regulation during embryonic organ formation. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":8},{"id":"GO:0003148","count":8},{"id":"GO:0035116","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0035902","count":7}]},{"hash":"1553729594402842804","title":"Signaling Pathway Inhibitors","description":"The top GO terms cluster around negative regulation of multiple signaling cascades (MAPK/ERK, PI3K/AKT, T cell receptor signaling) along with related processes like focal adhesion and synaptic organization, suggesting these proteins broadly dampen signaling and connectivity rather than promote activation. A occasional kinetochore localization term is present but does not define the core theme.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034501","count":14},{"id":"GO:0045736","count":14},{"id":"GO:0070373","count":12},{"id":"GO:0050860","count":12},{"id":"GO:0000200","count":12}]},{"hash":"2017523000573127332","title":"Embryonic development and transcription regulation","description":"The dataset shows enrichment for both transcriptional regulation by RNA polymerase II and a range of tissue-specific developmental processes (eye morphogenesis, camera-type eye development, cerebellum/midbrain development, motor neuron guidance, skeletal muscle development, lung branching, prostate gland morphogenesis). This suggests proteins that broadly regulate transcription during embryonic development across multiple tissues, rather than a single pathway or tissue. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0048048","count":8},{"id":"GO:0043010","count":7},{"id":"GO:0007519","count":7},{"id":"GO:0060441","count":7}]},{"hash":"2219829958710653042","title":"Stress Response and DNA Repair","description":"This cluster is populated by GO terms indicating responses to antibiotics, cold, and heat, alongside DNA repair and cell cycle processes, with supporting RNA surveillance and mRNA catabolic activity terms. Together, these terms point to a cohesive theme of stress response coupled with genome maintenance and RNA quality control.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0006281","count":2}]},{"hash":"1713600803562214072","title":"Neural synapse assembly and adhesion cluster","description":"The dominant terms point to neural connectivity: positive regulation of synapse assembly, synapse organization, nervous system development, and axonal fasciculation, plus homophilic/heterophilic cell adhesion. Rho signaling regulation hints at cytoskeletal remodeling crucial for these processes. Some terms (ossification and sensory perception of sound) are peripheral to the cluster, but the core theme is neural synapse formation and adhesion.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0043931","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0007157","count":3}]},{"hash":"198792043200508151","title":"Bone Development and Vascular-Neural Signaling","description":"The top GO terms point to bone maturation and multicellular development (ossification, development), with concurrent signals related to hypoxia response, blood coagulation, and VEGF signaling, plus neural/ion-channel related processes (neurotransmitter secretion, potassium channel clustering) and protein interactions (heterotrimerization, autophosphorylation). Together, these suggest a cluster integrating bone development with vascular and neural signaling components, rather than a single, narrow function.","confidence":"Medium","size":18,"edges":11,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0043931","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0070208","count":4}]},{"hash":"1782918475089768081","title":"Rho/Rac GTPase\u2013mediated actin remodeling","description":"These proteins sit at the crossroads of small GTPase signaling (Rho/Rac), GTPase activation, and actin cytoskeleton organization, with links to prostaglandin-responsive pathways and IGF receptor signaling. The shared GO terms point to coordinated cytoskeletal dynamics and regulatory signaling controlled by Rho family GTPases, supporting a cohesive theme of actin remodeling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045671","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0090630","count":3},{"id":"GO:0035021","count":3},{"id":"GO:0048009","count":3}]},{"hash":"867766275422794628","title":"Unknown","description":"The GO terms are highly diverse, including development (multicellular organism development, forebrain development), adhesion (cell-matrix adhesion), multiple signaling pathways (hedgehog/SMO, PDGF receptor), immune/microbial response (muramyl dipeptide), hormonal signaling (FSH stimulus), apoptosis, and pain perception, with no network edges to link them. This lack of a cohesive functional theme makes a specific, confident label untenable, so the cluster is best described as Unknown.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007275","count":15},{"id":"GO:0071372","count":10},{"id":"GO:0007160","count":10},{"id":"GO:0032495","count":10},{"id":"GO:0030900","count":10}]},{"hash":"1144912671386130932","title":"Nuclear ribosome biogenesis and cell cycle","description":"The cluster is enriched for nuclear processes including ribosome biogenesis (ribosome biogenesis, ribosomal large subunit biogenesis), transcription and RNA processing (DNA-templated transcription, mRNA splicing via spliceosome), and mitotic functions (cell division, mitotic spindle assembly). These point to a cohesive theme around ribosome production and cell cycle control within the nucleus, with additional chromatin-related regulation (histone acetylation) supporting transcriptional regulation and developmental signals (brain development) as broader annotations. Confidence in this label is Medium.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0000747","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0090307","count":4}]},{"hash":"502605095988883007","title":"NF-kB\u2013linked immune signaling and lymphocyte homeostasis","description":"This cluster centers on immune signaling and lymphocyte regulation, with multiple terms pointing to NF-kappaB pathway activity, responses to LPS and xenobiotics, and maintenance of B and T cell homeostasis, along with regulation of T cell proliferation. The dominant theme is immune activation and lymphocyte homeostasis, despite a few terms related to heart development and insulin secretion that appear less central.","confidence":"High","size":18,"edges":17,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0001666","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0032496","count":2}]},{"hash":"1660127353348915325","title":"Innate immune signaling and cytoskeletal remodeling","description":"The terms point to innate immune pathways (NOD2 signaling, NF-kappaB regulation, inflammatory mediator and chemokine production) and cytoskeletal dynamics (ruffle assembly, actin cortical patches) with accompanying calcium release into the cytosol, suggesting a module linking microbe sensing to inflammatory responses and cytoskeletal changes.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0005975","count":2},{"id":"GO:1900027","count":2}]},{"hash":"57069417033537547","title":"GPCR signaling in vascular and immune responses","description":"This cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling pathways, including dopamine receptor signaling, prostaglandin response, and blood pressure regulation, together with immune processes such as neutrophil chemotaxis and regulation of TNF production. This points to a cohesive module where GPCR activity modulates cAMP signaling to control vascular tone and inflammatory responses, with supporting signals from Rho-mediated pathways involved in cytoskeletal dynamics.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":9},{"id":"GO:0045777","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0007191","count":8},{"id":"GO:0071380","count":8}]},{"hash":"1829098228490834951","title":"Mitotic Cell Cycle Regulation and Ubiquitination","description":"This cluster is dominated by GO terms tied to mitosis and protein degradation, including mitotic cell cycle, cell division, APC-dependent catabolic process, and protein polyubiquitination, indicating a core theme of cell-cycle control and ubiquitin-mediated proteolysis. Some development-related terms (forebrain development, multicellular organism development) may reflect broader roles or annotation noise, but the strongest signal centers on mitosis and ubiquitination.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030900","count":4},{"id":"GO:0007338","count":3},{"id":"GO:0060528","count":3},{"id":"GO:0007275","count":3},{"id":"GO:2001162","count":3}]},{"hash":"607550264677023370","title":"Unknown","description":"The top GO terms span immunity, development, signaling, and cellular stress with no single cohesive function linking them, so a unified label isn\u2019t confidently supported.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0043931","count":3},{"id":"GO:0006914","count":3},{"id":"GO:0090086","count":2},{"id":"GO:0006936","count":2}]},{"hash":"1787753748356953996","title":"GTPase signaling and cytoskeletal dynamics","description":"The terms show a clear emphasis on small GTPase\u2013mediated signaling and regulation of Rho and stress fibers, plus positive/negative regulation of GTPase activity, with supplementary themes in NFAT/calcium signaling and ER stress responses. This points to a cohesive theme of GTPase-driven signaling that modulates cytoskeletal dynamics and broader cellular signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051531","count":3},{"id":"GO:0002244","count":2},{"id":"GO:0008625","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0007264","count":2}]},{"hash":"1027485362800829903","title":"Neural and epithelial tissue development","description":"This cluster\u2019s top GO terms point to development across neural (brain and spinal cord development) and epithelial/skin lineages (skin development), along with collagen fibril organization indicating extracellular matrix remodeling that accompanies morphogenesis. Additional terms about multicellular growth, protein oligomerization, and signaling (peptidyl-tyrosine phosphorylation) support a broader role in developmental processes and tissue formation. Overall, the proteins appear to participate in coordinated development and morphogenesis of neural and epithelial tissues.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0007584","count":2}]},{"hash":"1284632466753228132","title":"Neural development and sensory perception","description":"The GO terms cluster around nervous system development and sensory processes (neural tube development, nervous system development, detection of light stimulus in visual perception, long-term memory) and neuronal signaling (sodium ion transmembrane transport), suggesting a cohesive role in neural development and sensory function. A few terms related to non-neural processes appear but are infrequent and do not override the dominant neural/sensory theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":2},{"id":"GO:0007616","count":2},{"id":"GO:0032007","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0050908","count":2}]},{"hash":"1762504648681482029","title":"Carbohydrate and isoprenoid biosynthesis","description":"The Top Terms include carbohydrate metabolism (galactose/glycolysis-related) and isoprenoid/lipid biosynthesis (mevalonate pathway, farnesyl diphosphate, cholesterol), with some additional amino acid salvage processes. This mix points to broadly defined primary metabolic biosynthesis rather than a single, cohesive pathway, so the label reflects a general metabolic cluster rather than a specific process.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019287","count":1},{"id":"GO:0046835","count":1},{"id":"GO:0046396","count":1},{"id":"GO:0061623","count":1},{"id":"GO:0042352","count":1}]},{"hash":"955114618398988291","title":"Megakaryocyte and angiogenesis development with cytoskeleton dynamics","description":"These proteins are enriched for megakaryocyte development and angiogenesis terms, with frequent references to lamellipodium assembly and actin cytoskeleton dynamics, suggesting roles in cell migration and morphogenesis in hematopoietic/vascular contexts. The Kit signaling pathway and the immune-related term of negative regulation of T cell receptor signaling hint at cross-talk between developmental signaling and immune modulation. Overall, the terms support a developmental/morphogenesis module tied to cytoskeletal remodeling across tissues.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035855","count":4},{"id":"GO:2000251","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0010592","count":3}]},{"hash":"304677530839960504","title":"TLR Signaling and Immune Regulation","description":"The cluster data show a strong representation of toll-like receptor signaling pathways (TLR2/4/7 and TLR9) and related inflammatory control terms (e.g., negative regulation of IL-6 production and PI3K/AKT signaling modulation). While there are some developmental terms present (heart development, tracheal outgrowth), the dominant pattern points to innate immune signaling and its regulation, justifying a label centered on TLR-driven immune responses.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031954","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0045947","count":3},{"id":"GO:0034162","count":3},{"id":"GO:0007426","count":3}]},{"hash":"410964472343942373","title":"Mitochondrial dynamics and cytochrome c release","description":"This cluster is dominated by mitochondrial processes: protein import into the mitochondrial matrix, mitochondrial fusion, mitochondrial fragmentation in apoptotic processes, and release of cytochrome c, which together point to mitochondrial dynamics and apoptotic signaling. A few terms (hypothalamus development, retinol metabolism, complement activation) are less central in this context and may reflect incidental annotations.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0021854","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0042572","count":2}]},{"hash":"955826356702552757","title":"Mitochondrial Translation and Oxidative Phosphorylation","description":"This cluster centers on mitochondrial energy metabolism and protein synthesis, with GO terms for translation, mitochondrial electron transport, complex IV assembly, and ATP synthesis, plus related protein maintenance and stress-response processes. The combination suggests a functional module of mitochondrial protein production linked to respiration and ATP generation, despite some ancillary terms that may reflect broader cellular processes.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0055114","count":2},{"id":"GO:0006123","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0042776","count":1}]},{"hash":"1453252045270095480","title":"Organelle Protein Import","description":"Based on the strongest signals, the cluster is enriched for proteins involved in translocating and inserting proteins into organelle compartments, especially mitochondria and chloroplasts (protein import into mitochondrial matrix, into chloroplast stroma, and inner membrane insertion). Other terms are less central and may reflect noise or broader associations, but the core theme is organelle protein import. ","confidence":"High","size":17,"edges":30,"triangles":8,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":6},{"id":"GO:0007612","count":5},{"id":"GO:0042157","count":4},{"id":"GO:0006869","count":4},{"id":"GO:0042118","count":4}]},{"hash":"2102903496629034997","title":"Translation Regulation and Innate Antiviral Immunity","description":"This cluster is enriched for translation-related processes (translation, regulation of translational initiation by eIF2\u03b1 phosphorylation, positive regulation of translation, mRNA processing) and immune defense (innate immune response, negative regulation of viral genome replication), with additional stress-related signals (response to toxic substances, response to antibiotic) and a hint of DNA damage response. The combination points to a cohesive theme around coordinating protein synthesis with innate antiviral defense under stress, justifying the label.","confidence":"High","size":17,"edges":94,"triangles":364,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0046677","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0045071","count":3},{"id":"GO:0010998","count":3}]},{"hash":"1040251603597999733","title":"Signaling Pathway Activation and Development","description":"This cluster is enriched for GO terms describing positive regulation of multiple signaling pathways (ERK/MAPK cascade, Wnt signaling, phosphatidylinositol biosynthesis, Hedgehog/Smoothened) plus processes tied to development and cellular movement (axon guidance, mast cell chemotaxis, bone ossification, cell proliferation, exocytosis). The common thread is up-regulation of signaling networks that govern development, differentiation, and migration, making this label representative.","confidence":"High","size":17,"edges":34,"triangles":9,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":10},{"id":"GO:0010513","count":9},{"id":"GO:0090263","count":9},{"id":"GO:0002551","count":9},{"id":"GO:0007411","count":9}]},{"hash":"1026147034088660869","title":"Sugar and ion transport; vesicular neurotransmitter loading","description":"The top GO terms emphasize transmembrane transport of various sugars (glucose, xylose, galactose) and ions (nitrite, selenite) along with a process involved in loading neurotransmitters into synaptic vesicles, indicating a cohesive theme of membrane transport and vesicular handling of small molecules.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":6},{"id":"GO:0070715","count":6},{"id":"GO:0015753","count":6},{"id":"GO:0015757","count":6},{"id":"GO:0044381","count":6}]},{"hash":"1980085178236522243","title":"Glutamatergic synaptic signaling and receptor trafficking","description":"The cluster centers on glutamatergic synaptic transmission, with accompanying membrane trafficking features such as receptor recycling and endosome size regulation, plus calcium signaling and cytoskeletal/trafficking regulation (Rho signaling). A cohesive theme is neuronal communication involving synaptic signaling together with receptor trafficking and calcium-dependent modulation. ","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0035249","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0001881","count":2},{"id":"GO:0034968","count":2}]},{"hash":"2214611530869635654","title":"Synaptic signaling and plasticity","description":"This cluster is dominated by GO terms related to neuronal communication and synaptic regulation, including neurotransmitter secretion, long-term potentiation, and regulation of synaptic plasticity, suggesting a focus on synaptic signaling. Some terms touch on muscle development and broader cellular processes, but the core theme appears to be synaptic function and plasticity, potentially across neuromuscular contexts.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007520","count":9},{"id":"GO:0007269","count":7},{"id":"GO:0031914","count":7},{"id":"GO:0090153","count":7},{"id":"GO:0043065","count":7}]},{"hash":"1825573854197328047","title":"ER-Golgi organization and inflammatory cytokine signaling","description":"This cluster centers on endoplasmic reticulum and Golgi organization, membrane fusion, and vesicle trafficking, pointing to ER/Golgi dynamics. The simultaneous enrichment for immune-related terms such as defense response to virus and regulation of cytokine production (including IL-2) suggests a link to inflammatory signaling. Protein oligomerization and cell cycle regulation appear as broader supporting roles, but the strongest shared theme is organelle organization coupled with cytokine-mediated immune responses.","confidence":"Medium","size":17,"edges":14,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0016320","count":5},{"id":"GO:0051607","count":4},{"id":"GO:0007029","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0071158","count":4}]},{"hash":"921876301560426959","title":"Ubiquitination and Intracellular Transport","description":"Top terms are dominated by protein ubiquitination (including K6-linked) and intracellular protein transport, suggesting a group of proteins involved in post-translational modification and trafficking. Some annotations touch on chromatin regulation and cell-cycle signaling, with a few terms related to cytokine production, which may reflect signaling roles linked to ubiquitin dynamics. Overall, the cluster appears best described by ubiquitination-linked processes and intracellular transport, though the connection to immune signaling is weaker.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0048745","count":2},{"id":"GO:0085020","count":2},{"id":"GO:2000620","count":2}]},{"hash":"1926320692971486269","title":"Diverse Transmembrane Transporters","description":"These GO terms are all related to transmembrane transport, spanning xenobiotics, vitamins, ions (sodium, potassium, nitrate), sugars, and even neurotransmitter loading into synaptic vesicles. The variety of substrates points to a cluster of membrane transporter proteins with broad specificity rather than a single, narrow pathway.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0035725","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0015739","count":2}]},{"hash":"566035381262200893","title":"Mitochondrial respiration and protein oligomerization","description":"This cluster is dominated by GO terms for mitochondrial electron transport (ubiquinol to cytochrome c), aerobic respiration, and proton transmembrane transport, indicating mitochondrial energy production. Additional terms about protein oligomerization/heterooligomerization and protein targeting to mitochondrion reinforce a theme of mitochondrial protein complexes assembly and function. Some terms like insulin signaling or viral process are less central or ambiguous, but the core set supports mitochondrial respiration as the defining feature.","confidence":"High","size":17,"edges":19,"triangles":3,"max_degree":10,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0006122","count":4},{"id":"GO:0009060","count":4},{"id":"GO:0071432","count":4},{"id":"GO:1902600","count":4},{"id":"GO:0006627","count":3}]},{"hash":"1582290397922773635","title":"Neuronal signaling and vesicle trafficking","description":"This cluster is dominated by GO terms related to neuronal function and membrane trafficking: phosphatidylinositol-mediated signaling, neurotransmitter secretion, memory, pinocytosis, and positive regulation of GTPase activity, all pointing to synaptic signaling and vesicle trafficking in neurons. While a few terms like bone development and hypoxia response are broader cellular processes, the core signal aligns with neuronal communication and endocytic/trafficking activity.","confidence":"High","size":17,"edges":21,"triangles":7,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048015","count":3},{"id":"GO:0007269","count":3},{"id":"GO:0019800","count":3},{"id":"GO:0007613","count":3},{"id":"GO:0060348","count":3}]},{"hash":"608226893130755292","title":"Temperature-sensing and ion transport","description":"This cluster's top GO terms cluster around sensing temperature and pain, thermogenesis, and ion transmembrane transport, plus membrane depolarization events in cardiac tissue. The combination suggests proteins involved in temperature sensing and ion channel\u2013mediated signaling across membranes, including cardiac electrophysiology and sensory pathways; hence this name captures the shared theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0002024","count":9},{"id":"GO:0071502","count":9},{"id":"GO:0071805","count":7},{"id":"GO:0001666","count":7}]},{"hash":"2075960685754556631","title":"Calcium and metal ion transport and signaling","description":"The terms show strong emphasis on calcium ion import, calcium response, and general ion transport across membranes, plus membrane potential changes. Mn2+ transport appears as a related metal ion transport term. A few terms touch on temperature response and development, but the core signal is ion homeostasis and calcium signaling, suggesting a cluster tied to cellular ionic regulation and excitability rather than a single tissue/process.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0043931","count":7},{"id":"GO:0006828","count":7},{"id":"GO:0098703","count":7},{"id":"GO:0007275","count":7}]},{"hash":"1562762670976463494","title":"Steroid hormone biosynthesis","description":"The strongest signal in the GO terms is steroidogenesis, with aldosterone and cortisol biosynthetic processes present, suggesting the cluster centers on steroid hormone production. The other terms point to developmental and stress-related roles that may accompany endocrine signaling, but steroid biosynthesis is the core theme.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0032342","count":4},{"id":"GO:0021759","count":4},{"id":"GO:0097050","count":4}]},{"hash":"2049472974409179209","title":"Immune and epidermal differentiation signaling","description":"These proteins show enrichment for immune-related signaling (T cell receptor signaling, responses to LPS and GM-CSF) and transcriptional regulation, along with pathways governing cell fate decisions (Wnt, Hippo) and processes like apoptosis and keratinocyte differentiation, suggesting a theme of immune-activated signaling linked to epidermal differentiation and growth control.","confidence":"Medium","size":17,"edges":100,"triangles":277,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046827","count":11},{"id":"GO:0006351","count":8},{"id":"GO:0097011","count":8},{"id":"GO:0071222","count":8},{"id":"GO:0050852","count":8}]},{"hash":"153619614310459892","title":"Developmental Transcriptional Regulation and Patterning","description":"The terms point to core transcriptional control (RNA polymerase II), Notch signaling, and a set of organogenesis-related processes (floor plate development, somitogenesis, amacrine cell differentiation, nephron tubule morphogenesis, lung vasculature development). This suggests a cohesive theme where developmental gene expression programs shape tissue patterning and differentiation, with Notch as a key regulatory axis. Some terms like xenobiotic response and circadian regulation hint at broader regulatory layers but do not obscure the central developmental transcriptional theme.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0032922","count":9},{"id":"GO:0043433","count":9},{"id":"GO:0033504","count":9},{"id":"GO:0060426","count":9}]},{"hash":"1318618050648356868","title":"Rho-regulated adhesion and remodeling","description":"This cluster centers on cell\u2013cell and cell\u2013matrix adhesion, Rho-mediated signaling, and tissue remodeling processes (e.g., positive regulation of cell-matrix adhesion, tissue regeneration, hyaloid vascular plexus regression, osteoblast-related signaling). These themes point to cytoskeletal dynamics and adhesion driving development and regeneration, with a few metabolic terms that are less tied to adhesion. Overall, the dominant signal is Rho-driven adhesion and remodeling.","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0006656","count":2},{"id":"GO:0006364","count":2},{"id":"GO:2000146","count":2},{"id":"GO:0007266","count":2}]},{"hash":"1557536276658466763","title":"Potassium and sodium ion homeostasis and membrane potential","description":"This cluster is dominated by GO terms related to maintaining intracellular Na+ and K+ balance and regulating membrane potential (sodium/potassium ion import/export, membrane potential regulation). Such ion transport processes are central to neuronal signaling and excitable tissues, which is consistent with terms like sensory perception of pain and behavioral response to cocaine, as well as systemic regulators such as renal sodium excretion and blood pressure. Overall, the shared function appears to be ion homeostasis and membrane-potential control.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:1990573","count":4},{"id":"GO:0097623","count":4},{"id":"GO:0006883","count":4},{"id":"GO:0030007","count":4}]},{"hash":"1847093173460955194","title":"Neural synaptic signaling and monoamine regulation","description":"The top GO terms point to chemical synaptic transmission, neurotransmitter handling (glycine, serotonin, dopamine), and regulation of glycinergic transmission, along with brain development cues (thalamus development) and glial growth, indicating a coherent theme of neural communication and monoamine regulation in brain tissue.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007268","count":3},{"id":"GO:0061537","count":2},{"id":"GO:0042066","count":2},{"id":"GO:0051610","count":2},{"id":"GO:1905847","count":2}]},{"hash":"2031285209924517872","title":"Adaptive immune signaling and angiogenesis","description":"Based on the top GO terms, the proteins cluster around adaptive immune response and regulation of cytokine production (interleukin-3, GM-CSF), with accompanying processes like cell-cell adhesion and angiogenesis. While a CNS development term appears, the dominant themes point to immune signaling and vascular remodeling, suggesting these proteins coordinate immune activation with angiogenic processes. The recurring emphasis on positive regulation of signaling activities supports a cohesive immune- and vasculature-related function.","confidence":"High","size":17,"edges":43,"triangles":47,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":17},{"id":"GO:0045401","count":17},{"id":"GO:0016337","count":17},{"id":"GO:0001525","count":17},{"id":"GO:0007417","count":17}]},{"hash":"899982783372845945","title":"Proteoglycan biosynthesis and sulfation","description":"The top GO terms are dominated by proteoglycan and glycosaminoglycan biosynthetic processes (heparan sulfate, chondroitin sulfate, and heparin proteoglycans) and protein sulfation, plus related carbohydrate metabolism. This points to a coherent theme of extracellular matrix proteoglycan assembly and modification, with sulfation as a key post-translational step. Other terms (e.g., angiotensin regulation, embryonic morphogenesis) appear ancillary to this central function.","confidence":"High","size":17,"edges":49,"triangles":59,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":8},{"id":"GO:0030206","count":8},{"id":"GO:0002002","count":7},{"id":"GO:0006477","count":7},{"id":"GO:0006068","count":7}]},{"hash":"139102097633478870","title":"Secretory vesicle trafficking","description":"The dominant signals are Golgi vesicle budding and exosomal secretion, indicating a role in vesicle formation and release. Additional terms like dendrite development and keratinization point to vesicle-dependent processes in development and differentiation, while others (mitochondrion organization, synaptic vesicle regulation) reflect broader cellular logistics. Overall, this cluster centers on secretory/vesicle trafficking with developmental context.","confidence":"High","size":17,"edges":39,"triangles":28,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048194","count":16},{"id":"GO:1902766","count":16},{"id":"GO:0035690","count":16},{"id":"GO:0051291","count":16},{"id":"GO:0016358","count":16}]},{"hash":"22873781001843579","title":"Lipid catabolism and xenobiotic detox","description":"The cluster is characterized by several lipid-catabolic processes (triglyceride, monoacylglycerol, and phosphatidylserine catabolism) and detox/oxidative stress responses (cellular oxidant detoxification, cellular response to xenobiotic stimulus), suggesting a shared function in lipid metabolism tied to detoxification. Some terms related to biotin/antibiotic biosynthesis and tRNA methylation appear as minor associations but do not define the main theme.","confidence":"Medium","size":17,"edges":22,"triangles":7,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0019433","count":4},{"id":"GO:0006660","count":4}]},{"hash":"682014085597866160","title":"Retroviral Integration and Proviral Latency","description":"The GO terms point to steps of the retroviral life cycle: entry into the host nucleus, reverse transcription (RNA-templated DNA synthesis), DNA integration, and establishment of integrated proviral latency, with accompanying DNA replication/recombination processes. Additional terms about symbiont entry and host apoptosis modulation reflect virus\u2013host interactions and host defense manipulation, supporting a retroviral integration theme.","confidence":"High","size":17,"edges":93,"triangles":320,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0006310","count":6},{"id":"GO:0075732","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0006278","count":5}]},{"hash":"35627026292083925","title":"Visual System Development and Signaling","description":"The cluster's top GO terms cluster around visual system biology: retina layer formation and visual perception, reinforced by terms on neuronal synaptic plasticity and calcium signaling (ryanodine receptor regulation). Some terms (insulin secretion, proliferation, cardiac myofibril assembly) may reflect broader roles of multifunctional proteins, but the dominant theme is visual system development and neural signaling.","confidence":"Medium","size":17,"edges":105,"triangles":330,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035191","count":4},{"id":"GO:0035774","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0060315","count":4},{"id":"GO:0048168","count":4}]},{"hash":"873231085939462774","title":"Vesicle trafficking and endosome\u2013lysosome regulation","description":"The top GO terms cluster around intracellular transport, including endosome to lysosome and endosome to plasma membrane transport, lysosomal membrane organization, and small GTPase\u2013mediated signaling, which together suggest a coherent theme of endomembrane trafficking and vesicle regulation. Some terms (podosome assembly, floral organ abscission) are more peripheral, but the dominant signal points to vesicle trafficking processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000750","count":2},{"id":"GO:0051876","count":1},{"id":"GO:0006886","count":1},{"id":"GO:0007264","count":1},{"id":"GO:1902824","count":1}]},{"hash":"201625723238881557","title":"Embryonic development and morphogenesis","description":"This cluster\u2019s GO terms cluster around developmental processes across multiple tissues\u2014endoderm development, foregut morphogenesis, somite axis specification, lens differentiation, and seminiferous tubule development\u2014along with regulation of Rho signaling and transcription. The shared theme appears to be embryonic organogenesis and tissue morphogenesis driven by regulatory signaling and gene expression control.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0010718","count":2},{"id":"GO:0007492","count":2},{"id":"GO:0048617","count":2}]},{"hash":"1075644890408507943","title":"Neural development and synaptic signaling","description":"This cluster is dominated by GO terms related to brain development and neuronal signaling, including hippocampus development, excitatory postsynaptic potential, ephrin receptor signaling, canonical Wnt signaling, and dopamine response, pointing to neural development and synaptic communication as the core theme. Some terms (e.g., T cell receptor signaling and mitotic cell cycle) are present but appear less central to the cluster\u2019s primary function.","confidence":"Medium","size":17,"edges":36,"triangles":18,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000186","count":13},{"id":"GO:0090263","count":12},{"id":"GO:0050852","count":12},{"id":"GO:0048013","count":11},{"id":"GO:0021766","count":11}]},{"hash":"1389772923583439578","title":"Musculoskeletal Development and Morphogenesis","description":"The GO terms cluster around developmental processes and tissue morphogenesis, notably myoblast migration, somitogenesis, endothelial morphogenesis, and bone morphogenesis with regulation of osteoclast differentiation, suggesting a musculoskeletal development theme. The network connectivity is low (no edges), so this label is a best-effort summary rather than a tightly connected module.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0014839","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0006970","count":2}]},{"hash":"588485267540398121","title":"Neuroimmune signaling and myelination","description":"This cluster combines neural development signals (smoothened/Hedgehog pathway, myelination, transmission of nerve impulse) with innate immune and antiviral responses (defense response to virus, innate immune response, cytokine signaling, interferon production) and cell adhesion/tissue homeostasis, suggesting a group of proteins involved in neuroimmune crosstalk and myelination processes.","confidence":"Medium","size":17,"edges":40,"triangles":30,"max_degree":10,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007156","count":6},{"id":"GO:0048873","count":6},{"id":"GO:0019221","count":6},{"id":"GO:0051607","count":6},{"id":"GO:0007224","count":5}]},{"hash":"1904166030627201541","title":"Immune signaling and development","description":"The top GO terms show a strong emphasis on immune processes (adaptive immune response, innate immune response, B cell receptor signaling, IL-2 production) suggesting an immune-related function for this cluster. There are also development- and neuron-related terms (heart development, nervous system development, neuron projection development, synaptic potentiation) indicating potential pleiotropy or cross-talk between immune signaling and developmental/neural pathways. Overall, the cluster appears to center on immune signaling with ancillary developmental roles.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0002250","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0050853","count":3}]},{"hash":"1796283671122579175","title":"Gene expression machinery and cell cycle signaling","description":"The Top Terms show transcription, mRNA splicing, rRNA maturation, ribosome biogenesis, and translation initiation\u2014core gene-expression machinery\u2014along with signals for cell proliferation and TGF-beta responses. This points to a cluster centered on RNA processing and protein synthesis machinery, with ancillary cell-cycle and signaling regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071560","count":5},{"id":"GO:0008283","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0000398","count":4}]},{"hash":"1840646402959385650","title":"Calcium-dependent immune signaling","description":"The GO terms cluster around intracellular calcium signaling and pathways that control immune cell behavior, notably store-operated calcium entry, calcineurin-NFAT signaling, NK cell cytokine production, CCR7 signaling, and T cell proliferation regulation. While a couple of terms touch on chondrocyte and spermatid biology, the dominant theme is calcium-driven regulation of immune responses, supporting the name.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035584","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0035988","count":2},{"id":"GO:0032237","count":2},{"id":"GO:0002729","count":1}]},{"hash":"526836094879887612","title":"Developmental and immune signaling cluster","description":"The top GO terms show a mix of developmental processes (multicellular organism development, embryonic cranial skeleton morphogenesis) and immune/signaling pathways (Fc receptor signaling, interleukin-3 production, VEGF-PDGFR\u2013related signaling, STAT phosphorylation), plus general transcription and ribosomal export terms. This suggests the proteins participate in broad signaling functions related to development and immune responses rather than a single cohesive function, so a cautious, general label is appropriate.","confidence":"Low","size":17,"edges":17,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0097350","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0000055","count":3}]},{"hash":"2249743087470766256","title":"TNF/Cytokine and Apoptotic Signaling","description":"This cluster centers on immune/stress signaling: terms like positiveregulation of TNF production, cytokine production, JNK cascade, and NF-kappaB activity point to cytokine-driven and apoptotic pathways. Additional terms about PI3K/AKT signaling, insulin and growth hormone receptor signaling, and development suggest a broader signaling network that interfaces growth/metabolism with immune responses. Overall, a cohesive theme is cytokine- and stress-mediated signaling with links to growth and metabolic pathways.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":3},{"id":"GO:0051044","count":3},{"id":"GO:0046330","count":3},{"id":"GO:0042535","count":3},{"id":"GO:0051092","count":3}]},{"hash":"2070918465187449810","title":"Ubiquitination and protein turnover","description":"This cluster is dominated by GO terms related to ubiquitination and ubiquitin-dependent proteolysis (protein ubiquitination, ubiquitin-dependent protein catabolic process, K63-linked ubiquitination, autoubiquitination) with supportive links to JNK signaling, cell cycle, and even T cell homeostasis, suggesting a core theme of ubiquitin-mediated modification and degradation governing multiple pathways. Vitamin D response appears, but ubiquitination-centric terms are the strongest signal.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033280","count":8},{"id":"GO:0016567","count":7},{"id":"GO:0042787","count":6},{"id":"GO:0098907","count":5},{"id":"GO:0007049","count":5}]},{"hash":"1091752903505708738","title":"Hippocampal neuron development and synaptic signaling","description":"The cluster is dominated by GO terms tying to hippocampus development, dendrite morphogenesis, axon growth, and excitatory synaptic function (EPSP, calcium-dependent exocytosis, dopamine response, serine phosphorylation, JNK signaling), suggesting a cohesive module of hippocampal neuron maturation and synaptic activity. A minor inclusion of mitotic cell cycle terms appears as an outlier and does not override the neuronal theme.","confidence":"High","size":17,"edges":64,"triangles":91,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021766","count":17},{"id":"GO:0060079","count":17},{"id":"GO:0031647","count":17},{"id":"GO:1903351","count":17},{"id":"GO:0000278","count":17}]},{"hash":"597071569056567906","title":"Axon Development and Neurofilament Assembly","description":"This cluster is dominated by GO terms tied to neuronal axonogenesis/axon development, neurofilament bundle assembly, and microtubule-based organelle transport, indicating a cohesive neural growth/cytoskeleton function. A few immune-related terms are present but at much lower counts, reinforcing the neuronal theme. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903937","count":9},{"id":"GO:0048936","count":9},{"id":"GO:0033693","count":9},{"id":"GO:0001552","count":9},{"id":"GO:1902513","count":9}]},{"hash":"1244018556319317338","title":"NF-kappaB-Driven Inflammation and Immune Signaling","description":"The top GO terms cluster around NF-kappaB signaling (canonical pathway and its regulation), inflammatory response, and immune processes such as B cell apoptosis and immunoglobulin production, with links to JNK cascade and extrinsic apoptotic signaling, indicating a protein group focused on immune/inflammatory signaling and its cross-talk with apoptosis.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0046330","count":3},{"id":"GO:0001783","count":3},{"id":"GO:0002377","count":3},{"id":"GO:0097192","count":3}]},{"hash":"2237790651926839838","title":"Cardiac Development and Conduction","description":"GO terms point to heart development, cardiac muscle contraction, and regulation of SA node action potential, indicating proteins involved in cardiac formation and heart rhythm. While other terms like skin development, memory, T cell activation, and filopodium assembly appear, they are less represented and likely secondary. Overall, the core theme is cardiac development and conduction.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":3},{"id":"GO:0007613","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0060048","count":2}]},{"hash":"1825670413530389321","title":"Unknown","description":"The GO terms span diverse processes (ion transport, calcium signaling, thermogenesis, sensory perception/learning, and innate immune signaling) with no single cohesive function, and there are no edges linking proteins, so no specific, representative cluster label beyond Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030321","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0040015","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0051209","count":3}]},{"hash":"1235419952312116246","title":"Synaptic Vesicle Trafficking and Exocytosis","description":"The cluster shows enrichment for vesicle docking, exocytosis, and transport between Golgi, plasma membrane, endosomes, and lysosomes, pointing to neuronal vesicle trafficking and neurotransmitter release as the core function. The presence of terms related to synaptic plasticity and neuron survival supports a neuronal context, while autophagy-related terms are present but secondary. Overall, the dominant theme is synaptic vesicle cycling and membrane trafficking in neurons.","confidence":"High","size":17,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:1902902","count":3},{"id":"GO:0045956","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0035751","count":3}]},{"hash":"155657956192446279","title":"Neural and ocular morphogenesis","description":"Top GO terms are dominated by eye development (camera-type eye development, embryonic eye morphogenesis) and neural development (midbrain development, dopaminergic neuron differentiation), with additional signals related to transcription by RNA polymerase II. This suggests a set of proteins that participate in developmental programs shaping brain and eye tissues (and related craniofacial structures). Therefore a concise label capturing neural and ocular morphogenesis fits best.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0021983","count":6},{"id":"GO:0043010","count":5},{"id":"GO:0048048","count":5}]},{"hash":"168635863091734292","title":"Fibrinolysis, ECM remodeling, and angiogenesis","description":"The top GO terms cluster around fibrinolysis (plasminogen activation), complement activation via the lectin pathway, and collagen fibril organization, together with positive regulation of angiogenesis. This points to a cohesive theme of coagulation/fibrinolysis and extracellular matrix remodeling that supports vascular/angiogenic processes. Additional signaling terms such as Wnt signaling, receptor tyrosine kinase activation, and calcium response suggest broader signaling involvement in these contexts, while a few miscellaneous terms may reflect multifunctionality. Overall, the proteins likely participate in fibrinolysis and ECM remodeling with angiogenic signaling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":6},{"id":"GO:0001867","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0007171","count":4}]},{"hash":"28475372737009688","title":"Ubiquitin-dependent innate antiviral defense","description":"These proteins are enriched for innate immune and antiviral responses, with strong links to autophagy and ubiquitin signaling (K63-linked ubiquitination, ubiquitin-dependent degradation) and NF-\u03baB\u2013related inflammation, consistent with a coordinated host antiviral defense.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0051607","count":8},{"id":"GO:0006914","count":7},{"id":"GO:0051092","count":7},{"id":"GO:0070534","count":7}]},{"hash":"161763621984976508","title":"Developmental morphogenesis and signaling","description":"The GO terms cluster around broad developmental processes (multicellular organism development, organ induction, nervous system development) and specific morphogenesis events (branching in salivary gland morphogenesis, ossification) with linked signaling pathways (FGF receptor signaling, MAPKKK cascade). This suggests a cohesive theme of development and morphogenesis governed by signaling networks, hence a label capturing both aspects.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060445","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0001759","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0010765","count":2}]},{"hash":"52051022547894070","title":"Embryonic Development and Tissue Morphogenesis","description":"Many GO terms point to embryonic development and organ morphogenesis across tissues (placenta, cartilage, heart via EMT, pancreas) and patterning processes, suggesting a cluster of proteins involved in developmental differentiation and tissue formation. Some terms reflect general cellular machinery (RNA splicing, ribosomal export) that accompanies development but do not override the main theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":17},{"id":"GO:0060536","count":17},{"id":"GO:0060707","count":17},{"id":"GO:0060972","count":17},{"id":"GO:0000055","count":17}]},{"hash":"13534191994450649","title":"Embryonic development and morphogenesis","description":"The top terms cluster around developmental processes: placenta and mesoderm development, cartilage and hair follicle morphogenesis, and left-right pattern formation. This points to a theme of embryonic tissue formation and body plan establishment, with a few auxiliary terms related to oxidative stress and vitamin D regulation likely reflecting broader regulatory context rather than core function.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":17},{"id":"GO:0060536","count":17},{"id":"GO:0060707","count":17},{"id":"GO:0019430","count":17},{"id":"GO:0034396","count":17}]},{"hash":"947163578408434025","title":"Cytokine-regulated cell migration and angiogenesis","description":"The GO terms cluster around cell migration (general and fibroblast-specific) and negative/positive regulation of processes tied to vascular remodeling (angiogenesis) and growth, along with cellular responses to cytokines/growth factors (GM-CSF, IL-7, FSH). This suggests a theme where cytokine signaling drives cell movement and vascular-related regulation, making a migration/angiogenesis\u2013centered label appropriate.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0010763","count":3},{"id":"GO:0016477","count":3},{"id":"GO:2001275","count":3}]},{"hash":"1430553091609587398","title":"Sphingolipid and Fatty Acid Biosynthesis","description":"The top GO terms cluster around sphingolipid and fatty acid metabolism (sphingosine, sphinganine, monounsaturated fatty acid biosynthesis) and fatty acid response, suggesting the proteins share lipid biosynthetic functions. Some terms are obsolete or less directly linked (e.g., tarsal gland development, skin water regulation), but the core signal points to lipid biosynthesis and related barrier functions. ","confidence":"Medium","size":16,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0033561","count":2},{"id":"GO:0046512","count":2},{"id":"GO:1903966","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0006667","count":2}]},{"hash":"2121925656906470235","title":"Phosphoinositide-driven endomembrane organization","description":"This cluster centers on GO terms tied to phosphatidylinositol phosphate biosynthesis and endomembrane system organization, with additional signals of membrane remodeling and cytoskeletal dynamics (e.g., autophagosome assembly, focal adhesion, ruffle assembly). The recurring implication is phosphoinositide-regulated membrane trafficking and organization, even though a few terms appear less related or species-specific, which keeps the connection plausible but not definitively tight.","confidence":"Medium","size":16,"edges":15,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010256","count":2},{"id":"GO:0046854","count":2},{"id":"GO:0014066","count":2},{"id":"GO:2000786","count":2},{"id":"GO:0035855","count":2}]},{"hash":"294320250807770639","title":"Steroid and lipid biosynthesis","description":"The cluster shows a strong enrichment for biosynthetic processes of steroid hormones and related lipids (estrogen, glucocorticoids, C21-steroid hormones, fatty acid elongation, mycolic acid, retinoic acid, etc.), along with other lipid/cofactor biosynthesis pathways (tetrahydrobiopterin). This points to a cohesive theme around production of signaling molecules and lipid-based metabolites, with a few transcriptional regulation and antibiotic response terms as broader secondary roles. High","confidence":"","size":16,"edges":99,"triangles":326,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":16},{"id":"GO:0006703","count":15},{"id":"GO:0046677","count":15},{"id":"GO:0006704","count":15},{"id":"GO:0009710","count":15}]},{"hash":"1849837535988673593","title":"RNA processing and ribosome biogenesis","description":"The cluster shows strong enrichment for RNA processing and export (mRNA splicing via spliceosome, mRNA export, mRNA stabilization) along with components of translation initiation and ribosome assembly (formation of preinitiation complex, small-subunit processome assembly). This points to a core function in RNA processing and assembly of the ribosomal/translation machinery, with minor association to translation reinitiation in viral contexts.","confidence":"High","size":16,"edges":113,"triangles":473,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":10},{"id":"GO:0048025","count":10},{"id":"GO:0001825","count":10},{"id":"GO:0001731","count":10},{"id":"GO:0048026","count":10}]},{"hash":"1270648392820259346","title":"Heart development and organ morphogenesis","description":"The cluster shows strong signals for cardiac tissue development, including left ventricular morphogenesis, outflow tract morphogenesis, and Purkinje-related signaling, along with responses to epinephrine and neurotransmitter secretion. While some terms point to broader organ development (bone ossification, skin, kidney development), the cardiac-related terms dominate, suggesting these proteins collectively participate in heart morphogenesis and related organ development pathways.","confidence":"High","size":16,"edges":95,"triangles":322,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":12},{"id":"GO:0072221","count":11},{"id":"GO:0043588","count":10},{"id":"GO:0007275","count":10},{"id":"GO:0014850","count":8}]},{"hash":"541172252426679234","title":"Cerebellar cortex development and Bergmann glia differentiation","description":"The cluster is enriched for terms tied to cerebellar development (cerebellar cortex formation) and Bergmann glial cell differentiation, plus associated processes like regulation of axon regeneration. The inclusion of insulin signaling and negative regulation of MAPK/ERK and T cell receptor signaling suggests coordinated modulation of signaling pathways during neural development and glial differentiation. Overall, the proteins appear to function together in cerebellar development and glial maturation rather than a single non-neural process.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030948","count":12},{"id":"GO:0070373","count":12},{"id":"GO:0050860","count":12},{"id":"GO:0000200","count":12},{"id":"GO:0008286","count":11}]},{"hash":"1316217388290441728","title":"Transmembrane transporters for xenobiotics and sugars","description":"This cluster is dominated by GO terms for transmembrane transport across membranes, especially xenobiotic transport and sugar/monosaccharide transport, with supporting ion transport terms. The proteins likely function as membrane transporters handling diverse substrates, notably xenobiotics and carbohydrates like glucose, galactose, and xylose, across membranes.","confidence":"High","size":16,"edges":72,"triangles":117,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":16},{"id":"GO:0035461","count":16},{"id":"GO:0071805","count":13},{"id":"GO:0042908","count":13},{"id":"GO:0042891","count":12}]},{"hash":"421123203996748105","title":"RNA Splicing and mRNA Turnover","description":"The terms are dominated by RNA processing activities: mRNA splicing via spliceosome, spliceosomal complex assembly, deadenylation-dependent decapping, and P-body assembly, along with tRNA processing and SSU-rRNA maturation, plus RNA pol II transcription termination. While a few terms touch chromatin and ABA signaling, the core signal is RNA maturation and post-transcriptional regulation.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0045292","count":13},{"id":"GO:0030490","count":12},{"id":"GO:1990141","count":12},{"id":"GO:0033962","count":12},{"id":"GO:0006369","count":12}]},{"hash":"585067188069566698","title":"GPCR Signaling and Regulation","description":"The top GO terms cluster around G protein-coupled receptor signaling, including receptor internalization, GPCR activation of adenylyl cyclase, calcium signaling linked to PLC, and ERK cascade regulation, with additional context in blood pressure and pain perception\u2014consistent with GPCR-mediated pathways across tissues and cell types.","confidence":"High","size":16,"edges":60,"triangles":62,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051482","count":11},{"id":"GO:0002031","count":11},{"id":"GO:0045986","count":11},{"id":"GO:0007190","count":11},{"id":"GO:0019233","count":11}]},{"hash":"1979938194671660375","title":"GPCR-cAMP signaling in vascular smooth muscle","description":"The top GO terms cluster around adenylate cyclase-activating GPCR signaling, activation of adenylate cyclase, and regulation of blood pressure, all pointing to GPCR-driven control of vascular smooth muscle tone. Additional terms like Rho signaling and calcium-related GPCR pathways reinforce this theme. The electron transport chain term appears incidental to the GPCR signaling focus, possibly reflecting energy needs in muscle cells. Overall, this cluster appears to represent GPCR-mediated signaling regulating vascular smooth muscle function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0007190","count":10},{"id":"GO:0035025","count":10}]},{"hash":"990569985721846622","title":"Dopaminergic Neuronal Signaling and Drug Response","description":"The cluster\u2019s top GO terms heavily feature dopaminergic synaptic transmission, behavioral responses to cocaine, and related neural signaling (with supporting terms like estradiol, prostaglandin response, xenobiotic response, and sensory/visual perception), suggesting a cohesive theme around neural signaling and drug-related responses. While a few terms touch broader development or other systems, the core appears centered on neuronal communication and psychoactive drug responsiveness.","confidence":"Medium","size":16,"edges":56,"triangles":53,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0042493","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0032355","count":4},{"id":"GO:0048148","count":4}]},{"hash":"185725492143281374","title":"DNA replication and damage response","description":"The top GO terms are dominated by DNA replication and recombination, plus apoptosis and oxidative stress response, suggesting a nuclear module involved in DNA metabolism and stress-induced cell fate. Some other terms appear less cohesive (xenobiotic response, lipid signaling), but the core theme centers on DNA synthesis/repair and stress-related apoptosis.","confidence":"Medium","size":16,"edges":64,"triangles":130,"max_degree":15,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0006260","count":6},{"id":"GO:0070301","count":6},{"id":"GO:0006915","count":6},{"id":"GO:1903507","count":5}]},{"hash":"405992955301887675","title":"Innate Immunity and Cell Cycle Stress Response","description":"Top GO terms indicate strong enrichment for innate immune response, dsRNA response, and apoptosis, alongside factors involved in cell cycle regulation (kinetochore localization, CDK activity). The mixture suggests a cluster tied to stress and immune signaling that intersects with cell cycle control, with additional signaling context from insulin and dopamine pathways. Confidence: Medium","confidence":"","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045087","count":13},{"id":"GO:0006915","count":12},{"id":"GO:0034501","count":11},{"id":"GO:0045736","count":11},{"id":"GO:0043330","count":11}]},{"hash":"1522497042318534290","title":"Protein homeostasis and stress-induced apoptosis","description":"The cluster is characterized by terms related to protein synthesis and degradation (ribosome biogenesis, proteasome assembly, rRNA processing) alongside apoptosis signaling (mitochondrial depolarization with cytochrome c release, extrinsic TNF pathway). This suggests a theme of cellular stress response and maintenance of protein homeostasis that can trigger cell death pathways under stress.","confidence":"Medium","size":16,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0051901","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0009553","count":2}]},{"hash":"1527707189986827619","title":"Cerebellar development and neural signaling","description":"The cluster\u2019s top GO terms center on cerebellar cortex formation, Bergmann glial differentiation, and axon regeneration, with insulin receptor signaling also represented, suggesting a cohesive theme of cerebellar neural development and associated signaling pathways. A few terms (like T cell receptor signaling) seem incidental, but do not override the core cerebellar-development signal.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0008286","count":15},{"id":"GO:0048679","count":15},{"id":"GO:0021697","count":15},{"id":"GO:0008285","count":15},{"id":"GO:0050852","count":15}]},{"hash":"904482843212601292","title":"Unknown","description":"The top GO terms are a mix of skin development, neural and sensory functions (startle response, innervation, sensory perception of sound, circadian sleep/wake regulation), plus unrelated processes (calcium transport, kidney filtration, bone ossification, cardiac action potentials, and GPCR signaling). The lack of a clear, single functional theme and no observed edges among proteins suggest there isn\u2019t a cohesive cluster function to name beyond Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0001964","count":2},{"id":"GO:0060384","count":2},{"id":"GO:0045188","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1227389345411502057","title":"Embryonic organ development with transcriptional regulation","description":"The proteins are enriched for transcription-related terms (DNA-templated transcription and its positive regulation) alongside diverse embryonic development processes such as heart formation (AV canal development, EMT in endocardial cushions), palate morphogenesis, pituitary and endocrine development, cartilage formation, and placenta-related differentiation, indicating a role in developmental gene regulation across tissues.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045893","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0036302","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0021983","count":2}]},{"hash":"250595108224920363","title":"Mesoderm Development and Stem Cell Proliferation","description":"The cluster centers on mesoderm formation and stem cell differentiation, with strong signals for DNA-templated transcription and re-entry into the mitotic cell cycle, plus pathways that promote cell proliferation (VEGF/PDGF signaling). Additional terms point to developmental remodeling and matrix regulation, consistent with mesodermal development and growth. This cohesive theme supports a label focused on developmental progenitor dynamics and proliferation within the mesoderm lineage.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":16},{"id":"GO:0014850","count":16},{"id":"GO:0006351","count":16},{"id":"GO:2000738","count":16},{"id":"GO:0001707","count":16}]},{"hash":"1233705048764581541","title":"Insulin signaling and vascular morphogenesis","description":"The top GO terms include insulin processing and regulation of insulin secretion, paired with venous blood vessel morphogenesis and collateral sprouting, suggesting a link between insulin signaling and vascular development. Supporting terms about forskolin response and signaling regulation imply broader coupling of endocrine signaling with cell adhesion and phosphorylation pathways, reinforcing a theme of insulin-related regulation of angiogenesis and vascular remodeling.","confidence":"Medium","size":16,"edges":31,"triangles":21,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007588","count":2},{"id":"GO:0030070","count":2},{"id":"GO:0010815","count":2},{"id":"GO:0061178","count":2},{"id":"GO:0051893","count":2}]},{"hash":"507252924980512564","title":"Unknown","description":"The top GO terms span neural development, viral processes, cell cycle and mitosis control, DNA repair, innate immune signaling, spindle checkpoint regulation, peptide transport, peroxisome import, ubiquitin chemistry, and telomere maintenance. This broad and disparate mix provides no clear, shared function or pathway linking the proteins, so a single cohesive label isn\u2019t discernible.","confidence":"","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0010976","count":16},{"id":"GO:0016032","count":16},{"id":"GO:0000086","count":16},{"id":"GO:0042275","count":16},{"id":"GO:0035666","count":16}]},{"hash":"2194627589305467818","title":"Rho GTPase\u2013driven cytoskeleton remodeling and synaptic regulation","description":"This cluster centers on actin-based remodeling controlled by small GTPases (filopodium assembly and its regulation) and related cell adhesion, spreading, and migration processes, with links to synaptic transmission and vesicle trafficking (Golgi vesicle budding). Mitochondrial fission appears as a supporting facet of dynamic organelle changes during remodeling. Overall, the proteins likely coordinate cytoskeletal dynamics, signaling, and trafficking underlying synaptic function and cell movement.","confidence":"High","size":16,"edges":23,"triangles":8,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051932","count":5},{"id":"GO:0046847","count":5},{"id":"GO:0051489","count":5},{"id":"GO:1900026","count":5},{"id":"GO:0000266","count":5}]},{"hash":"665385471607503793","title":"RNA decay and stress granule dynamics","description":"This cluster is best described as RNA decay and stress granule dynamics, driven by enrichment for deadenylation-dependent decay, P-body assembly, and stress granule assembly, indicating coordinated post-transcriptional regulation during stress; other terms (e.g., NF-kappaB regulation, synaptic potentiation) are present but less central.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":2},{"id":"GO:0034063","count":1},{"id":"GO:0043124","count":1},{"id":"GO:1900271","count":1},{"id":"GO:0033962","count":1}]},{"hash":"1411175309118775332","title":"Embryonic angiogenesis and placental development signaling","description":"The terms center on embryonic development, vascularization (angiogenesis), and placental formation (pregnancy, chorio-allantoic fusion), with supporting signaling pathways including Hedgehog (Smoothened), Rho, and PI3K, plus ceramide metabolism. Together they suggest a developmental signaling module that promotes angiogenesis and placental formation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0050732","count":2},{"id":"GO:2000304","count":2},{"id":"GO:0007224","count":2}]},{"hash":"1788338641084547625","title":"Embryonic morphogenesis and mesoderm development","description":"The top GO terms point to embryonic tissue formation across multiple lineages, including mesoderm development, cartilage morphogenesis, placental/trophoblast differentiation, left-right patterning, and craniofacial structures (roof of mouth, hair follicle morphogenesis). This suggests a overarching theme of embryonic morphogenesis rather than a single tissue-specific function. Confidence: High","confidence":"","size":16,"edges":15,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":15},{"id":"GO:0060536","count":15},{"id":"GO:0060707","count":15},{"id":"GO:0034396","count":15},{"id":"GO:0007498","count":15}]},{"hash":"2284005005734663953","title":"Unknown","description":"The top GO terms span neural signaling (regulation of synaptic plasticity and AMPA receptor activity), immune/mitogenic signaling (NF-kappaB and FGFR pathway regulation), apoptosis (p53-mediated DNA damage response), metabolism (cholesterol biosynthesis), hematopoiesis, and even bacterial processes (peptidoglycan biosynthesis). This broad mix shows no single cohesive function or theme linking all 16 proteins, suggesting possible annotation noise or a highly heterogeneous cluster. Therefore, there is no confident common function to assign.","confidence":"","size":16,"edges":15,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:1901223","count":2},{"id":"GO:0048172","count":2},{"id":"GO:2000311","count":2},{"id":"GO:0040037","count":2},{"id":"GO:0042771","count":2}]},{"hash":"511859845082021805","title":"Cytoskeletal remodeling and vesicle trafficking in development","description":"This cluster combines actin-based remodeling (actin filament bundle assembly, cell migration) with vesicle trafficking (COPII-coated vesicle cargo loading) and epithelial polarity, plus mechanosensing and development-related processes, suggesting coordinated cytoskeleton\u2013trafficking roles during tissue morphogenesis.","confidence":"Medium","size":16,"edges":21,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090110","count":4},{"id":"GO:0045737","count":4},{"id":"GO:0006909","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0071260","count":3}]},{"hash":"851157307555761574","title":"Actin Remodeling and Cell Adhesion Signaling","description":"This cluster is dominated by GO terms for actin filament polymerization and branching, small GTPase\u2013mediated signaling, and positive regulation of podosome assembly, cell spreading, and adhesion, pointing to coordinated cytoskeletal remodeling. Additional signaling terms like ephrin and T cell receptor signaling support cytoskeleton modulation in immune and neuronal contexts, reinforcing a cohesive theme of actin-driven remodeling and cell adhesion.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071803","count":4},{"id":"GO:0043652","count":4},{"id":"GO:0048013","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0050852","count":4}]},{"hash":"555176642710432223","title":"Proteostasis and ECM remodeling","description":"The terms cluster around protein turnover (proteasome assembly, ubiquitin-dependent catabolic process) and extracellular matrix dynamics (integrin signaling, ECM assembly regulation, cell adhesion, hyaluronan metabolism, cell migration), suggesting a theme of proteostasis linked to cell\u2013matrix interactions. Some terms like chlorophyll biosynthesis and endodermal differentiation seem outliers, possibly due to cross-species annotations or noise, but the dominant signal is proteolysis coupled with ECM remodeling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043248","count":9},{"id":"GO:0035987","count":9},{"id":"GO:0034113","count":9},{"id":"GO:0015995","count":9},{"id":"GO:0006929","count":9}]},{"hash":"2234087014181025535","title":"Autophagy and lipid catabolic processes","description":"The top GO terms point to autophagy-related turnover (piecemeal microautophagy of the nucleus, vacuolar protein processing) and several lipid- and phospholipid-catabolic processes (triglyceride, arachidonate, phosphatidylserine catabolism), suggesting a shared theme of cellular degradation and lipid metabolism. Some terms (endocannabinoid signaling, camalexin biosynthesis) may be peripheral or incidental to the core theme. Confidence in a cohesive functional label is therefore Medium.","confidence":"Medium","size":16,"edges":19,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0034727","count":2},{"id":"GO:0098921","count":1},{"id":"GO:0080151","count":1},{"id":"GO:1901183","count":1},{"id":"GO:0007216","count":1}]},{"hash":"2014698932270477909","title":"Unknown","description":"The top GO terms cover immune response to lipopolysaccharide, vision-related light detection, placental differentiation, general translation, neuromuscular posture control, blood pressure regulation, pain response, TNF signaling, and one-carbon metabolism. The terms are highly diverse and there is no clear cohesive functional theme or interaction pattern among the proteins, so a single interpretable label cannot be assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0050908","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0050884","count":1}]},{"hash":"1474722992284411631","title":"Cytokine signaling and lymphocyte differentiation","description":"The top GO terms strongly point to immune development and cytokine signaling (interleukin-7 response, IL-4 production, B cell affinity maturation, NK T cell differentiation, hematopoiesis). Additional terms for ephrin receptor signaling and nitric oxide response align with immune signaling and inflammation. A metabolic signaling term (insulin pathway) may reflect metabolic regulation within immune cells rather than a primary theme. Overall, the cluster appears to group immune cell development and cytokine-mediated signaling.","confidence":"Medium","size":16,"edges":36,"triangles":33,"max_degree":15,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0098761","count":16},{"id":"GO:0032633","count":16},{"id":"GO:0008286","count":16},{"id":"GO:0002344","count":16},{"id":"GO:0001865","count":16}]},{"hash":"1370106551074616037","title":"N- and Lysine-Protein Acetylation","description":"Most of the terms point to acetylation events, including several N-terminal acetylation variants and peptidyl-lysine, as well as polyamine acetylation (putrescine, spermine). This strong acetylation-focused signal suggests the proteins cluster around acetylation-related post-translational modifications, with a few additional biosynthetic terms that are less central to the main theme. Confidence reflects the clear, dominant acetylation pattern.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":15},{"id":"GO:0061606","count":15},{"id":"GO:0006526","count":15},{"id":"GO:0071962","count":15},{"id":"GO:0032919","count":15}]},{"hash":"1056043958673854757","title":"Apoptosis and mitochondrial stress signaling","description":"The cluster shows strong signals for apoptotic processes, necroptosis (ripoptosome assembly), and mitochondrial fission, pointing to a cell-stress\u2013driven death pathway. While there are auxiliary terms related to ER-associated degradation and transcription regulation, the prominent theme ties to apoptosis and mitochondrial dynamics in stress responses.","confidence":"Medium","size":16,"edges":79,"triangles":161,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000266","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0030433","count":3},{"id":"GO:1904378","count":3}]},{"hash":"2192396980846166839","title":"Synapse remodeling and actin dynamics","description":"The cluster centers on neuronal signaling and cytoskeleton remodeling: Rac-mediated actin dynamics (Rac signaling, filopodium/podosome assembly), synaptic processes (GABAergic transmission, acetylcholine receptor signaling, synapse structural plasticity), and membrane remodeling activities (endocytosis). The presence of heart development is likely peripheral to the main theme, while the rest points to coordinated synaptic plasticity and cytoskeletal changes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0016601","count":4},{"id":"GO:0006897","count":3},{"id":"GO:0051835","count":3},{"id":"GO:0007213","count":3}]},{"hash":"405348264100815108","title":"Lectin-mediated innate immune activation","description":"The top GO terms are dominated by innate immune signaling related to the lectin pathway and C-type lectin receptors (complement activation via lectin pathway, stimulatory C-type lectin receptor signaling), along with phagocytosis recognition and basophil activation. This suggests the cluster groups proteins involved in recognition of microbial components and initiation of inflammatory responses. Some development-related terms are present, but the strongest signal points to lectin-based innate immunity.","confidence":"High","size":16,"edges":16,"triangles":3,"max_degree":7,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0001502","count":9},{"id":"GO:0071226","count":9},{"id":"GO:0006910","count":7},{"id":"GO:0001867","count":6},{"id":"GO:0045575","count":6}]},{"hash":"626915874728232143","title":"Developmental morphogenesis and differentiation","description":"The suite of top terms is dominated by embryonic development and organ morphogenesis across tissues (placenta, cartilage, endocrine organs, EMT in heart, pancreatic cells, trophoblasts, left-right patterning, hair follicles). This points to a cluster of proteins involved in differentiation and morphogenesis during development. A few RNA processing terms appear but don't define the cluster.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":14},{"id":"GO:0060536","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0003323","count":14}]},{"hash":"222900891891811015","title":"Epithelial Polarity and Cell-ECM Adhesion","description":"The cluster centers on epithelial organization, with multiple terms about maintaining follicular epithelium polarity and follicle cell adhesion in the insect egg chamber, plus broader cell-cell adhesion and extracellular matrix components such as proteoglycans. While a few terms (e.g., teichoic acid biosynthesis) seem incongruent and may reflect annotation noise, the dominant signal points to epithelial polarity and adhesion processes, potentially during development and morphogenesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042248","count":3},{"id":"GO:0007299","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0071555","count":3}]},{"hash":"1891821757663477339","title":"Wnt signaling and immune regulation","description":"This cluster prominently includes Wnt signaling (GO:0016055) and several immune/modulatory terms such as positive regulation of macrophage inflammatory protein 1 alpha production and chemokine production, along with cell growth and multicellular organismal process terms. The recurring themes point to signaling pathways that coordinate immune responses and cellular growth, though some terms are broad, making the exact functional tie somewhat diffuse.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0016055","count":7},{"id":"GO:0048549","count":7},{"id":"GO:1904743","count":6},{"id":"GO:0071642","count":6}]},{"hash":"1934006954318468097","title":"Neural Development and Synapse Assembly","description":"The dominant GO terms point to nervous system and sensory development (inner ear, brain), along with synapse assembly and locomotory behavior, suggesting the proteins collectively function in neural connectivity and sensory system formation. Some terms touch on cardiac/endothelial development, which may reflect broader developmental regulation, but the strongest signal is neural development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":7},{"id":"GO:0007626","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007420","count":5},{"id":"GO:1903142","count":4}]},{"hash":"1393853423565514789","title":"Embryonic Organogenesis and Differentiation","description":"The GO terms cluster around embryonic development and organ formation, including pancreas, mesoderm, cartilage, and endocrine system development, along with processes like EMT in heart cushions and left-right patterning, indicating a cohesive role in tissue morphogenesis and lineage specification.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5}]},{"hash":"619894025497099424","title":"Embryogenesis and Organ Morphogenesis","description":"This cluster is dominated by GO terms linked to embryonic development and tissue morphogenesis (placenta, cartilage, pancreas, and heart-related differentiation; left/right axis formation and EMT), suggesting a shared role in developmental differentiation and organogenesis. Some RNA processing terms are also present, likely reflecting general gene-expression activity during development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":15},{"id":"GO:0060536","count":15},{"id":"GO:0060707","count":15},{"id":"GO:0060972","count":15},{"id":"GO:0000055","count":15}]},{"hash":"2037612822025113523","title":"Rac-dependent actin remodeling","description":"The top GO terms emphasize actin cytoskeleton dynamics such as microspike and lamellipodium assembly, along with Rac GTPase signaling and positive regulation of GTPase activity. This points to Rac-mediated actin remodeling as the central theme for this cluster, with neural development terms like myelination and midbrain morphogenesis likely reflecting broader cytoskeletal roles in neural processes. The sparse edges suggest a cohesive functional group focused on cytoskeletal regulation rather than broader network connections.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":3},{"id":"GO:0022011","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0016601","count":3},{"id":"GO:0030032","count":3}]},{"hash":"207793526973322696","title":"Ubiquitin-dependent antiviral immune response","description":"The top terms cluster around ubiquitin-mediated protein turnover (ERAD, ubiquitin-dependent degradation, K63-linked ubiquitination, aggresome formation) and antiviral/innate immune defense (defense response to virus, innate immune response, host-mediated suppression of viral processes). This suggests a module where ubiquitination pathways interface with antiviral signaling and proteostasis to restrain viral activity.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":12},{"id":"GO:0042787","count":12},{"id":"GO:0051607","count":11},{"id":"GO:0051865","count":11},{"id":"GO:0045087","count":11}]},{"hash":"1986175458025916871","title":"Synaptic vesicle exocytosis regulation","description":"The top terms are dominated by regulation of synaptic vesicle exocytosis, along with calcium response, intracellular transport, and brain development, which together point to neuronal vesicle trafficking and calcium-dependent signaling. Although a couple of terms come from plant or yeast contexts, the strongest signal across the cluster centers on synaptic vesicle regulation and associated endocytosis/transport processes in neurons.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:2000300","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0036324","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0031384","count":3}]},{"hash":"503702332492211716","title":"Epidermal Barrier & Junction Formation","description":"The top GO terms point to skin-related processes: establishment of skin barrier, hair follicle morphogenesis, and regulation of cell-cell adhesion and tight junctions, all of which suggest roles in epidermal development and barrier maintenance. While a few terms touch broader signaling (insulin receptor signaling, osteoclast regulation), the dominant pattern supports a theme of epidermal barrier formation and junction organization.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061436","count":3},{"id":"GO:0045779","count":3},{"id":"GO:0045671","count":3},{"id":"GO:0031069","count":2},{"id":"GO:0046627","count":2}]},{"hash":"1909680941151441667","title":"Actin cytoskeleton remodeling and cell motility","description":"This cluster is strongly enriched for actin-based protrusion and remodeling terms (lamellipodium, filopodium, microspike assembly) and for regulators of Rho GTPase signaling and GTPase activation, all of which drive cytoskeletal dynamics and cell movement. The presence of positive regulation of substrate adhesion-dependent cell spreading and regulation of Rho signaling supports a cohesive theme around actin-driven motility and adhesion, with some developmental cues (midbrain morphogenesis, vessel remodeling) that can be linked to cytoskeletal processes. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":3},{"id":"GO:1904693","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0090630","count":3}]},{"hash":"12844093700732844","title":"Caveolin-mediated endocytosis and neuronal migration","description":"The cluster shows strong representation of GO terms related to caveolin-mediated endocytosis and caveola assembly, membrane invagination, and actin filament organization, plus processes tied to cell migration and neuron development (including radial glia-guided migration). This suggests a coherent functional theme around caveolae-driven membrane remodeling that supports actin-driven movement during neural development and neuronal migration, justifying a label that captures both endocytic/caveolar activity and neural migration.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072584","count":3},{"id":"GO:0010324","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0007015","count":3},{"id":"GO:0070836","count":3}]},{"hash":"481294999479816582","title":"Unknown","description":"There is no shared GO signal or connectivity to define a common function for these 16 proteins: Top Terms are empty, and the graph has no edges or triangles, so no coherent biological theme is evident. The ReCIPE note about re-adding one protein does not establish functional linkage across the cluster. Therefore, the label Unknown is appropriate with no confidence.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1099307299323091429","title":"Embryonic morphogenesis and development","description":"The terms center on embryonic tissue formation across mesoderm, placenta, cartilage, hair follicles, and facial structures (roof of the mouth), with left-right patterning\u2014indicating a developmental/morphogenetic theme. A few regulatory terms are present, but the dominant signal is embryonic morphogenesis, making this label representative.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060707","count":16},{"id":"GO:0007498","count":16},{"id":"GO:0031069","count":16}]},{"hash":"1576736217098930874","title":"Embryonic development and morphogenesis","description":"This cluster is dominated by GO terms tied to embryogenesis and tissue morphogenesis\u2014mesoderm development, placenta-related differentiation, cartilage and hair follicle morphogenesis, and craniofacial patterning. The consistent theme is developmental differentiation and morphogenesis during embryonic development. A couple terms about regulatory processes outside classic morphogenesis are present but peripheral.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060707","count":16},{"id":"GO:0007498","count":16},{"id":"GO:0031069","count":16}]},{"hash":"1199899978494993452","title":"Unknown","description":"The GO terms span insect excretory/kidney development, synapse biology, immune signaling, and vascular processes, with no clear common function or network connectivity among the proteins, so no cohesive label can be assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050930","count":2},{"id":"GO:0002860","count":2},{"id":"GO:0061330","count":2},{"id":"GO:0045404","count":2},{"id":"GO:0097206","count":2}]},{"hash":"1614735628711816233","title":"ER Proteostasis and Redox Regulation","description":"The dominant GO terms cluster around endoplasmic reticulum\u2013associated protein folding, glycosylation, and redox control (redox homeostasis, oxidative stress response, deglutathionylation), suggesting a proteostasis network in the ER with redox regulation; other terms like transcription regulation and viral process may reflect broader stress or host\u2013virus interactions but are secondary to the core ER proteostasis theme.","confidence":"High","size":15,"edges":41,"triangles":43,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034975","count":13},{"id":"GO:0045454","count":12},{"id":"GO:0006351","count":10},{"id":"GO:0018279","count":10},{"id":"GO:0034599","count":10}]},{"hash":"549630350782361059","title":"Epidermal differentiation and skin barrier formation","description":"The cluster's GO terms cluster around keratinization, epidermal differentiation and establishment of the skin barrier, indicating a primary skin-related function. While terms like nervous system development and bone remodeling appear, the strongest signal points to epidermal processes.","confidence":"Medium","size":15,"edges":25,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050873","count":2},{"id":"GO:0030334","count":2},{"id":"GO:0046849","count":2},{"id":"GO:0031424","count":2},{"id":"GO:0007399","count":2}]},{"hash":"951392584519961930","title":"Renin-angiotensin system and vascular regulation","description":"The top GO terms cluster around regulation of blood pressure via the renin-angiotensin system, regulation of renin secretion, glomerular filtration, and hormone secretion, with related smooth muscle contraction and signaling. A few terms point to immune or behavioral processes and xenobiotic response, but the dominant theme is cardiovascular-endocrine/renal control, justifying this label as representative.","confidence":"Medium","size":15,"edges":12,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":13},{"id":"GO:0035625","count":13},{"id":"GO:0001991","count":13},{"id":"GO:0002300","count":13},{"id":"GO:0003093","count":13}]},{"hash":"321501467540157434","title":"Ion transport and neuronal temperature signaling","description":"The cluster shows multiple GO terms tied to ion transmembrane transport (sodium, potassium, calcium), neural-associated responses (startle, pain perception, prepulse inhibition), and temperature- and circadian-related processes (thermogenesis, cellular response to temperature, circadian sleep/wake cycle). This pattern points to a group of proteins involved in neuronal signaling governed by ionic gradients and temperature cues, with a weaker association to non-neuronal processes.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":3},{"id":"GO:0045188","count":3},{"id":"GO:0098703","count":3}]},{"hash":"2155096763987314680","title":"Amino acid biosynthesis and carbohydrate catabolism","description":"The cluster\u2019s frequent terms center on amino acid biosynthesis (L-proline, L-valine) and various carbohydrate-related processes (carbohydrate phosphorylation, galactarate and inositol catabolic processes), suggesting a core of metabolic enzymes involved in amino acid production and sugar metabolism. Some terms like brain development and iron import are less coherent with this theme and may reflect annotation noise. Overall, this label captures the main functional theme.","confidence":"Medium","size":15,"edges":19,"triangles":5,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045730","count":3},{"id":"GO:0046835","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0055129","count":2}]},{"hash":"1641908193474836975","title":"Energy Metabolism and Oxidative Stress","description":"This cluster centers on energy balance and metabolic regulation, with links to energy reserve metabolism, energy homeostasis, and brown fat differentiation, alongside a component of oxidative stress response and basic protein maintenance (modification/repair). The mix suggests proteins involved in sustaining energy status under stress, possibly with adipose tissue relevance, though some terms are obscure/obsolete, so the label is a best-fit rather than definitive.","confidence":"Medium","size":15,"edges":21,"triangles":4,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006464","count":1},{"id":"GO:0030091","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0006979","count":1},{"id":"GO:0007631","count":1}]},{"hash":"1481106801209725034","title":"Immune Response and Cell Adhesion","description":"The Top Terms are dominated by immune-related processes: innate and adaptive immune responses, complement activation, and regulation of T cell proliferation, along with a GO term for cell adhesion. These collectively point to immune system activation and cell\u2013cell interactions as the core function of this cluster, with only a few ribosome biogenesis terms suggesting minor housekeeping noise. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045162","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0046007","count":2}]},{"hash":"437956922987143904","title":"Renin-Angiotensin-Hormonal Kidney Regulation","description":"The top GO terms cluster around renal endocrine control of circulatory function, including regulation of blood pressure via the renin-angiotensin system, regulation of renin secretion, and regulation of glomerular filtration, as well as hormone secretion. These point to a coherent theme of kidney-mediated hormonal control of cardiovascular physiology. Some terms (e.g., CD8 T cell differentiation, operant conditioning, xenobiotic response) appear unrelated and may reflect annotation noise or multi-function proteins, but the dominant signal supports a renal hormonal regulation theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":13},{"id":"GO:0035625","count":13},{"id":"GO:0001991","count":13},{"id":"GO:0002300","count":13},{"id":"GO:0003093","count":13}]},{"hash":"308581861730301643","title":"Sex hormone biosynthesis and reproductive development","description":"The cluster is strongly enriched for terms related to sex differentiation, female gonad development, and mammary gland development, along with androgen metabolism and testosterone biosynthesis, pointing to a cohesive theme of reproductive development and hormone production. Secondary terms like xenobiotic catabolic processes and methylation/phosphorylation suggest supportive regulatory or metabolic layers rather than core functions. ","confidence":"High","size":15,"edges":21,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":3},{"id":"GO:0008209","count":3},{"id":"GO:0007548","count":3},{"id":"GO:0061370","count":3},{"id":"GO:0016310","count":3}]},{"hash":"684259009996901477","title":"Neural-Immune Homeostasis and Stress Response","description":"This cluster combines neural-related processes (response to electrical stimulus, CNS myelin maintenance, eye morphogenesis) with immune functions (complement activation, T cell homeostasis) and stress/apoptosis pathways (intrinsic apoptotic signaling under oxidative stress, negative regulation of necroptosis) as well as tissue cell-number homeostasis. The shared theme appears to be maintenance of neural and tissue homeostasis under stress, spanning neural and immune signaling contexts.","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0048593","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0060546","count":2}]},{"hash":"128921578917217078","title":"Vesicle trafficking and signaling proteins","description":"These proteins map to endosome-to-plasma membrane transport and a broad set of signaling processes across neuromuscular control, bone development, immune responses, and metabolic regulation, suggesting a common role in vesicle trafficking and receptor localization that shapes diverse physiological contexts.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":2},{"id":"GO:0009607","count":2},{"id":"GO:0030282","count":2},{"id":"GO:0035456","count":2},{"id":"GO:0035455","count":2}]},{"hash":"294368513874868117","title":"Golgi-to-membrane vesicle trafficking and SNARE assembly","description":"This cluster is dominated by GO terms describing vesicle transport within and from the Golgi (ER-Golgi, intra-Golgi, Golgi ribbon formation, Golgi-to-vacuole) and SNARE complex assembly, together with exocytic insertion of neurotransmitter receptors to the postsynaptic membrane and receptor localization to the cell surface. The common theme is secretory trafficking from the Golgi to the plasma membrane, mediated by SNAREs, with implications for synaptic receptor delivery and membrane organization.","confidence":"High","size":15,"edges":47,"triangles":68,"max_degree":12,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048280","count":14},{"id":"GO:0006888","count":14},{"id":"GO:0090161","count":14},{"id":"GO:0006891","count":14},{"id":"GO:0060291","count":13}]},{"hash":"955759497652695377","title":"Embryonic Eye and Heart Morphogenesis","description":"Top terms point to camera-type eye development, lens/eye morphogenesis, embryonic heart tube development, and patterns of early organogenesis (left-right, somitogenesis). This indicates a cluster centered on embryonic development of the eye and heart, with supporting transcriptional regulation activity. Therefore, the label captures the shared theme of organogenesis in these tissues.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0043010","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0060441","count":5},{"id":"GO:0006366","count":5}]},{"hash":"152002354779479185","title":"Multi-organ development and differentiation","description":"The terms cluster around developmental processes across various organs (heart, limb, adrenal gland, gonads, adipose tissue) and developmental biology (embryo implantation, brain neuron generation), plus general transcription activity; together they indicate a group of proteins involved in broad organogenesis and lineage differentiation rather than a single pathway.","confidence":"Medium","size":15,"edges":24,"triangles":8,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0007566","count":5},{"id":"GO:0030325","count":5},{"id":"GO:0045444","count":5},{"id":"GO:0008584","count":5}]},{"hash":"913078376960990203","title":"Mitochondrial Metabolism, Cofactor Synthesis, and Iron Homeostasis","description":"The TOP GO terms point to mitochondrial processes (mitochondrial translation) and core metabolic/cofactor biosynthesis (branched-chain amino acid biosynthesis, molybdopterin cofactor biosynthesis, coenzyme B biosynthesis), along with iron handling (intracellular iron ion homeostasis and response to iron ion starvation). Taken together, these suggest a cluster focused on mitochondrial metabolism and essential cofactor production, with a clear link to iron management. Some terms are broad or obsolete, but the overall theme is coherent enough to label as mitochondrial metabolic and cofactor biosynthesis functions with iron involvement.","confidence":"Medium","size":15,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009097","count":4},{"id":"GO:0009098","count":4},{"id":"GO:0032543","count":4},{"id":"GO:0009089","count":4},{"id":"GO:0006777","count":3}]},{"hash":"1113728496330751520","title":"Secretory vesicle trafficking and exosomal secretion","description":"This cluster is enriched for Golgi vesicle budding and exosomal secretion, pointing to a core theme of secretory pathway activity. Additional terms like dendrite development and keratinization suggest involvement across diverse cell types and differentiation contexts, while xenobiotic response and mitochondrial regulation reflect broader cellular stress and organelle dynamics that often accompany secretion-related processes. The combination indicates a function centered on vesicle trafficking and secretion across development and tissue contexts.","confidence":"Medium","size":15,"edges":66,"triangles":132,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048194","count":15},{"id":"GO:1902766","count":15},{"id":"GO:0035690","count":15},{"id":"GO:0051291","count":15},{"id":"GO:0016358","count":15}]},{"hash":"1000392322369375018","title":"Developmental ECM Remodeling","description":"The Top Terms show a focus on developmental processes across tissues (inner ear, placenta, neural development, epithelial proliferation) and extracellular matrix turnover (collagen catabolic process). Immune activation terms (complement pathways) and transcription regulation appear but are less central, suggesting the cluster comprises proteins involved in development with ECM remodeling and related tissue remodeling processes. Therefore, \u201cDevelopmental ECM Remodeling\u201d is a concise, representative label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0048839","count":4},{"id":"GO:0001890","count":3},{"id":"GO:0030574","count":3},{"id":"GO:0006958","count":3}]},{"hash":"1773972230635722847","title":"Exocytosis and vesicle trafficking regulation","description":"These proteins are enriched for processes involving vesicle fusion, exocytosis, synapse and muscle cell fusion, and signaling pathways that govern cytoskeletal dynamics (Rho, PI signaling) and vesicle targeting. The combination of vesicle fusion regulation, synaptic/muscle assembly, and secretory signaling across neurons, muscles, and endothelium suggests a cohesive role in regulated membrane trafficking and secretion. ","confidence":"High","size":15,"edges":99,"triangles":386,"max_degree":14,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007520","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0030948","count":7},{"id":"GO:0007416","count":7},{"id":"GO:0031340","count":6}]},{"hash":"1710709864349859515","title":"Neuronal Ion Channels and Synaptic Signaling","description":"The GO terms cluster around ion transport (potassium, sodium, calcium import) and key neural communication processes (GABA signaling, excitatory postsynaptic potentials), as well as behavior-related terms like startle response, locomotion, sensory processing, and circadian sleep regulation. This combining of ion channel/transport activity with synaptic transmission and behavior supports a cohesive theme of neuronal signaling and ion channel function. Hence the label reflects both the molecular and behavioral aspects of the cluster.","confidence":"High","size":15,"edges":12,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":10},{"id":"GO:0001661","count":9},{"id":"GO:0007214","count":9},{"id":"GO:0060079","count":9},{"id":"GO:0007626","count":9}]},{"hash":"1651585075693132382","title":"Embryonic and placental development","description":"The top GO terms cluster around embryogenesis, placental morphogenesis, and related developmental processes (including cartilage and pancreatic cell development, EMT in heart development, left-right patterning, and spindle assembly), suggesting a broad developmental/morphogenesis theme rather than a specific molecular function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0003323","count":3}]},{"hash":"1457959736751506268","title":"T/NK cell activation and cytotoxic regulation","description":"This cluster centers on adaptive immune signaling and cytotoxic regulation, with frequent terms for T cell costimulation, T cell proliferation, and regulation of NK cell cytotoxicity and cytokine production. It also highlights CCR7 signaling and actin cytoskeleton remodeling at cell\u2013cell interfaces, consistent with immune synapse formation. Immunoglobulin production is present but less dominant, so the core theme is T/NK cell\u2013mediated immune activation and control.","confidence":"High","size":15,"edges":93,"triangles":324,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0090138","count":8},{"id":"GO:0002377","count":8},{"id":"GO:0031295","count":8},{"id":"GO:0002859","count":8},{"id":"GO:0043318","count":8}]},{"hash":"1446226308859229658","title":"LPS-Driven inflammation and coagulation","description":"The proteins show enrichment for immune- and coagulation-related GO terms, including response to lipopolysaccharide, complement activation, and regulation of blood coagulation. This points to an inflammation/hemostasis axis as the cluster's main theme, despite a few terms related to transcription regulation and neuronal synaptic plasticity that may reflect broader regulatory roles or annotation noise. Overall, the dominant signal favors inflammatory response and coagulation pathways.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0000122","count":3}]},{"hash":"358439703976682516","title":"GTPase signaling and actin dynamics in synapses","description":"The dominant terms cluster around positive regulation of GTPase activity, actin crosslink formation, and barbed-end actin filament capping, along with long-term synaptic potentiation, pointing to signaling-driven cytoskeletal remodeling at synapses as the core theme. Some terms also touch on tyrosine phosphorylation and broader signaling (TGF-beta, heart development, immunological synapse), but the central connection appears to be GTPase-mediated signaling that governs actin dynamics in neuronal contexts.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0031954","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0051764","count":3}]},{"hash":"1195699590019320871","title":"Ubiquitin-regulated transcription and proteolysis","description":"The cluster repeatedly features GO terms for ubiquitination and ubiquitin-dependent protein degradation (e.g., SCF-dependent proteasomal ubiquitin-dependent catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process, protein autoubiquitination) alongside transcription-related terms (negative regulation of transcription by RNA polymerase II, DNA-templated transcription). There are also development-related signals (response to TGF-beta, endocardial cushion morphogenesis), suggesting a role in development where ubiquitin-mediated control of transcription factors modulates gene expression. Overall, the proteins seem tied to how ubiquitination controls transcriptional activity, with a developmental context.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0016567","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0048873","count":3},{"id":"GO:0031146","count":3}]},{"hash":"180021438701299029","title":"Neural maturation and myelination","description":"The terms show a strong emphasis on nervous system development, including myelination (GO:0042552) and regulation of neuron maturation (GO:0014041), plus a dopamine-related cellular response (GO:1903351), indicating neuronal maturation and signaling; some terms involve vascular or immune processes (angiogenesis, endothelial migration, IL-8 production, lipopeptide detection) that may reflect broader cross-talk but do not define the cluster, so the neural maturation/myelination theme is the best fit.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0045416","count":2},{"id":"GO:0010596","count":2},{"id":"GO:0016525","count":2},{"id":"GO:1903351","count":2}]},{"hash":"1225428956598908400","title":"Unknown","description":"The top GO terms span disparate vertebrate developmental processes (midbrain, inner ear, palate roof, hindlimb, primitive streak, endothelial barrier, gonad, atrial tissue) and a transcriptional regulation term, plus an unrelated immune/complement term. This lack of a single cohesive function or theme makes it difficult to assign a specific, concise label beyond Unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:1903142","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0048839","count":3},{"id":"GO:0060021","count":3}]},{"hash":"1009310194504063813","title":"Brain and Sensory System Development","description":"This cluster is enriched for terms related to brain and sensory organ formation and function, including brain and midbrain development, camera-type eye and inner ear development, visual perception, locomotory behavior, and positive regulation of synapse assembly, suggesting a cohesive theme of neural and sensory system development. Some terms are more general (transcription regulation, endothelial barrier), but the dominant pattern centers on neural and sensory organ development.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:1903142","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0048839","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0007420","count":5}]},{"hash":"552449508122705519","title":"Innate immune signaling regulation and gene silencing","description":"The top GO terms cluster around modulation of innate immune pathways (negative regulation of Toll signaling, Toll-like receptor signaling, and T cell proliferation) and antimicrobial responses, with positive regulation of NOD2 signaling, suggesting overall immune signaling control. The presence of regulatory ncRNA-mediated gene silencing and DNA repair via nonhomologous end joining hints at broader gene expression and genome maintenance roles accompanying immune regulation. Together, these terms point to proteins that regulate innate immune signaling and related cell fate responses.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0097680","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0008348","count":1}]},{"hash":"1380410210925387838","title":"Neural development and connectivity","description":"The terms cluster around neural development and function: neuron migration, dendrite self-avoidance, cell-cell adhesion, and transmission of nerve impulses, with ion-channel clustering indicating synaptic/excitability organization. While a couple of terms touch on tissue homeostasis or innate immunity, the dominant theme is establishing and maintaining neural circuits. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0019226","count":3},{"id":"GO:0016337","count":3},{"id":"GO:0001764","count":3},{"id":"GO:0051291","count":2}]},{"hash":"33137100718712846","title":"Cell division and tissue development signaling","description":"The top terms show a strong cell cycle focus (cell division; mitotic sister chromatid separation; mitotic cytokinesis; meiotic chromosome separation), alongside development-related processes (mesenchymal proliferation in lung development, hair follicle placode formation, maintenance of organ identity) and TGF-beta signaling. This suggests a cluster where core cell division machinery intersects with broader developmental signaling pathways that coordinate tissue formation, hence a combined theme of cell cycle control and development. ","confidence":"Medium","size":14,"edges":36,"triangles":45,"max_degree":10,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0051306","count":5},{"id":"GO:0000281","count":5},{"id":"GO:0050852","count":4},{"id":"GO:0071560","count":4}]},{"hash":"1504576098916701821","title":"Amino acid and polyamine metabolism","description":"The GO terms cluster around amino acid biosynthesis and catabolism (proline, beta-alanine, arginine via ornithine, alanine transamination) and polyamine-related pathways (putrescine, GABA catabolism), suggesting a core theme of amino acid and polyamine metabolism. There are a couple of outliers related to redox and developmental regulation, but the dominant signal supports a metabolic focus.","confidence":"Medium","size":14,"edges":23,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060672","count":2},{"id":"GO:0055129","count":1},{"id":"GO:0015995","count":1}]},{"hash":"35753771564866375","title":"Immune signaling and hematopoietic development","description":"The top GO terms show strong emphasis on adaptive immunity (adaptive immune response, B cell receptor signaling pathway, IL-2 production) and blood/immune lineage development (megakaryocyte development), suggesting a cluster centered on immune signaling and hematopoiesis. Some terms related to Rho signaling and ion transport may reflect broader signaling contexts but do not override the dominant immune/hematopoietic theme.","confidence":"High","size":14,"edges":16,"triangles":0,"max_degree":8,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":9},{"id":"GO:0010765","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0061000","count":7},{"id":"GO:0002250","count":6}]},{"hash":"1264762352606933976","title":"Renin\u2013Angiotensin Hormonal and Vascular Regulation","description":"The dominant GO terms center on blood pressure regulation via the renin\u2013angiotensin system, hormonal secretion, and kidney/vascular functions (glomerular filtration, smooth muscle contraction), with related signaling (cAMP, GPCR/EGFR). A few terms (T cell differentiation, operant conditioning) appear as potential outliers or annotation noise, but the core theme is endocrine and renal-vascular control.","confidence":"Medium","size":14,"edges":35,"triangles":19,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":14},{"id":"GO:0035625","count":14},{"id":"GO:0001991","count":14},{"id":"GO:0002300","count":14},{"id":"GO:0003093","count":14}]},{"hash":"1340940245483383464","title":"Innate immune and mechanosensory signaling","description":"Top GO terms suggest a theme of bacterial stimulus response (lipopolysaccharide response; defense against Gram-positive bacteria) together with mechanosensory signaling (response to mechanical stimulus; sensory perception of sound). The inclusion of intracellular signal transduction and transcription regulation terms supports downstream gene regulation following such stimuli. Some terms are obsolete, indicating annotation noise or older ontologies. Overall, this cluster likely represents a stimulus-responsive signaling and transcriptional regulation module rather than a single narrow function.","confidence":"Medium","size":14,"edges":12,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1795231751483574728","title":"Embryonic development and organogenesis","description":"The cluster includes GO terms spanning placental and cartilage morphogenesis, pancreatic cell development, heart EMT-related formation, and left\u2013right patterning, pointing to a cohesive theme of embryogenesis and tissue morphogenesis. Telomere maintenance terms appear more as generic cellular processes rather than core themes, so the main signal is development and organ formation.","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032211","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2}]},{"hash":"1234502326325179467","title":"Stem Cell Differentiation and Mesoderm Formation","description":"The top GO terms point to developmental processes and cell cycle regulation, notably mesoderm formation, positive regulation of stem cell differentiation, and DNA-templated transcription, along with re-entry into the mitotic cell cycle and replication. This suggests a coordinated program where progenitor cells proliferate and activate transcriptional networks to commit to mesodermal fates. Some outlier terms (biofilm and filamentous growth) may reflect broader or noisy annotations, but the dominant theme aligns with stem-cell\u2013driven mesoderm development and associated cell-cycle control.","confidence":"Medium","size":14,"edges":77,"triangles":228,"max_degree":13,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":14},{"id":"GO:0014850","count":14},{"id":"GO:0006351","count":14},{"id":"GO:2000738","count":14},{"id":"GO:0001707","count":14}]},{"hash":"2010735343552984550","title":"Embryonic and organ morphogenesis","description":"This cluster is dominated by GO terms related to developmental morphogenesis across multiple tissues and organs (eye, hindlimb, heart, placenta, prostate, habenula, etc.), indicating a general embryonic morphogenesis program rather than a single pathway. The presence of a regulatory term for transcription supports a broader developmental regulation theme. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":8},{"id":"GO:0008584","count":8},{"id":"GO:0060527","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1639880889771078639","title":"Zinc ion transport and homeostasis","description":"The cluster centers on GO terms related to zinc handling, including zinc ion import across the plasma membrane, intracellular zinc ion homeostasis, detoxification, and cellular response to zinc ion conditions, suggesting proteins function together in zinc uptake and maintenance of zinc balance. A lone limb development term appears, but the zinc-related terms overwhelmingly define the cluster\u2019s theme.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":1},{"id":"GO:0070574","count":1},{"id":"GO:0006830","count":1},{"id":"GO:0034224","count":1},{"id":"GO:0044749","count":1}]},{"hash":"706159966749818853","title":"Developmental Morphogenesis","description":"The top GO terms center on embryonic development, tissue and organ morphogenesis, and differentiation (placenta, mesoderm, cartilage, hair follicle, pancreatic cells, left-right patterning). This points to a broad developmental/morphogenetic theme across multiple tissues, rather than a single specific process.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":11},{"id":"GO:0060536","count":11},{"id":"GO:0060707","count":11},{"id":"GO:0060972","count":11},{"id":"GO:0035270","count":11}]},{"hash":"1482147007636209212","title":"GABAergic Synapse Assembly and Signaling","description":"This cluster is dominated by GO terms related to synaptic organization and neurotransmission, especially GABAergic transmission, neuroligin clustering in postsynaptic membranes, and regulation of synaptic vesicle clustering. Together these point to a cohesive role in forming and modulating inhibitory synapses. Additional terms about actin remodeling and GTPase activity support cytoskeletal changes required for synapse assembly and plasticity; a few terms on heart and nephron development appear as less central context. Overall, the synaptic assembly/signaling theme best captures the cluster\u2019s function.","confidence":"High","size":14,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006970","count":2}]},{"hash":"1356810646984290567","title":"Neural development and CNS patterning","description":"The cluster's GO terms point to neural development and brain regionalization (dopaminergic neuron differentiation, ventral spinal cord interneuron specification, cerebral cortex regionalization) along with transcriptional regulation (negative regulation of transcription by RNA Pol II, regulation of DNA-templated transcription). Additional embryonic organogenesis terms (roof of mouth development, regulation of somitogenesis, embryonic skeletal system development, pancreatic A cell development) support a broader developmental theme centered on transcription-controlled neural patterning.","confidence":"High","size":14,"edges":19,"triangles":0,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0071542","count":3},{"id":"GO:0021521","count":3},{"id":"GO:0006355","count":3}]},{"hash":"1799768834000695958","title":"Cardiovascular development and smooth muscle regulation","description":"This cluster is enriched for GO terms tied to heart vasculature and smooth muscle biology: pericardium morphogenesis, smooth muscle contraction and migration, cell-matrix adhesion (including calcium-independent adhesion), receptor clustering, nitric oxide biosynthesis, and blood coagulation. Together these point to cardiovascular development and remodeling with smooth muscle\u2013ECM signaling, rather than a single isolated process.","confidence":"High","size":14,"edges":8,"triangles":3,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007568","count":6},{"id":"GO:0045987","count":5},{"id":"GO:0003344","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0045429","count":4}]},{"hash":"1711817726069570608","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000462","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1121863960840349187","title":"Cardiac contraction regulation and immune signaling","description":"Reasoning: Several top GO terms point to regulation and relaxation of cardiac muscle contraction (GO:0086004, GO:0055119, GO:1901898, GO:0055118), indicating a core theme around cardiac function control. Additional terms indicate immune/vascular signaling involvement (GO:0050852 T cell receptor signaling pathway; GO:0097011 GM-CSF stimulus; GO:0043117 vascular permeability), suggesting interplay between cardiac regulation and immune-vascular signaling. While there are xenobiotic and dopamine-related terms as well, the strongest recurring signal centers on cardiac contractility regulation with related signaling processes, supporting this label.","confidence":"Medium","size":14,"edges":16,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":7},{"id":"GO:0086004","count":5},{"id":"GO:0055119","count":5},{"id":"GO:0097011","count":5},{"id":"GO:0035690","count":5}]},{"hash":"1323561618128715677","title":"Neural Development and Myelination","description":"This cluster is dominated by terms tied to brain development and connectivity: cell adhesion, corpus callosum development, myelination, collagen organization, and synapse assembly, alongside receptor tyrosine kinase signaling and ion channel clustering, all pointing to maturation and function of neural circuits.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007156","count":7},{"id":"GO:0042552","count":7},{"id":"GO:0022038","count":7},{"id":"GO:0030199","count":7},{"id":"GO:0007169","count":7}]},{"hash":"241227705099796892","title":"Embryonic Development and Differentiation","description":"The top GO terms point to embryonic development and differentiation across multiple lineages: neural development (axonogenesis, neural plate formation), placental/embryonic tissue differentiation (trophoblast giant cell differentiation, EMT in endocardial cushion), cartilage formation, endocrine system development, and pancreatic cell development. Although diverse, they reflect a shared theme of embryogenesis and organogenesis rather than a single pathway, suggesting this cluster captures general developmental programs.","confidence":"Medium","size":14,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007111","count":1},{"id":"GO:0015914","count":1},{"id":"GO:0007409","count":1},{"id":"GO:0021990","count":1},{"id":"GO:0060806","count":1}]},{"hash":"1028309375060002765","title":"Embryonic Morphogenesis and Skeletal Development","description":"The top GO terms cluster around early development and tissue formation, including organ induction, skeletal system and cranial skeleton morphogenesis, angiogenesis, and branching morphogenesis, all connected to BMP signaling and developmental signaling pathways (along with membrane protein intracellular domain proteolysis suggesting Notch-like signaling). This points to coordinated embryonic morphogenesis and skeletal/craniofacial development driven by signaling cascades. Therefore, the label reflects a vertebrate developmental morphogenesis theme with skeletal emphasis.","confidence":"High","size":14,"edges":21,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0031293","count":2},{"id":"GO:0001759","count":2},{"id":"GO:0002320","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0001501","count":2}]},{"hash":"437353119214772961","title":"Axon Guidance and Neuronal Maturation","description":"These proteins cluster around neural development: axonal fasciculation and axon extension in axon guidance indicate roles in wiring and connectivity, while regulation of neuron maturation and cellular response to dopamine point to maturation and neural signaling. PDGF receptor signaling supports broader developmental signaling, including neuro-vascular contexts, which aligns with the related, though less central, terms on angiogenesis and endothelial regulation. Overall, the theme best represents neural growth and maturation processes.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0048008","count":2},{"id":"GO:0045416","count":1}]},{"hash":"1491978480062265600","title":"Notch-Linked Immune and Stress Signaling","description":"The cluster prominently features Notch signaling alongside innate immune and inflammatory responses, implying a role in signaling that coordinates immune/stress responses. Additional terms on chromatin localization, mitochondrial fission, and phosphorylation suggest broader regulatory functions, though the inclusion of ion transport and cardiac conduction terms indicates diverse roles. Overall, a Notch-centered immune/stress signaling interpretation seems plausible, with moderate confidence.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0090141","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006954","count":2}]},{"hash":"1782316782716559856","title":"Mesoderm Formation and Stem Cell Proliferation","description":"The dominant terms center on mesoderm formation and stem cell differentiation, coupled with activation of the cell cycle and DNA replication, plus signaling that promotes proliferation (VEGF/PDGF pathway) and ECM remodeling. This points to a developmental program driving mesoderm development with coordinated proliferation and differentiation, rather than a single isolated function. Nitric oxide signaling also appears as a modulatory signal within this developmental context.","confidence":"High","size":14,"edges":15,"triangles":1,"max_degree":5,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":14},{"id":"GO:0014850","count":14},{"id":"GO:0006351","count":14},{"id":"GO:2000738","count":14},{"id":"GO:0001707","count":14}]},{"hash":"1666774230888953834","title":"Neurite outgrowth and dendrite morphogenesis","description":"The terms cluster around neuronal development and neurite growth (neuron projection development, axon extension, dendrite morphogenesis) with supporting roles for microtubule dynamics, calcium signaling, and synaptic protein localization, indicating a core function in neurite outgrowth and neuronal wiring.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":5},{"id":"GO:0045773","count":4},{"id":"GO:0050848","count":4},{"id":"GO:0031116","count":4},{"id":"GO:1901216","count":4}]},{"hash":"180845827910094375","title":"Developmental Regulation and Chromatin Remodeling","description":"The GO terms point to development across tissues (lens, heart, mammary, neural) and epigenetic regulation (chromatin remodeling, histone modification) along with signaling pathways, indicating proteins involved in developmental control with chromatin-level regulation rather than a single pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070309","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0097026","count":1},{"id":"GO:0006338","count":1}]},{"hash":"1737887743715502898","title":"Innate immune signaling and pyroptosis","description":"The top terms point to innate immunity and inflammatory signaling: innate immune response, pyroptotic inflammatory response, NOD-like receptor signaling, and MyD88-dependent TLR signaling, along with response to dsRNA and ubiquitination. A non-dominant term about mitotic spindle assembly appears incidental. Thus the cluster mainly reflects innate immune sensing and inflammatory cell death pathways, justifying this label.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016567","count":8},{"id":"GO:1990001","count":7},{"id":"GO:0006915","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0070269","count":7}]},{"hash":"196786317506504837","title":"Adenylate Cyclase-Activating GPCR Signaling","description":"This cluster is centered on GPCR signaling that activates adenylate cyclase and increases cAMP, including dopamine receptor signaling and prostaglandin E response, with links to blood pressure regulation and GPCR signaling modulation. While a few terms like the electron transport chain appear, the dominant theme is GPCR-cAMP signaling and its vascular/proliferative associations.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0007190","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0007191","count":6}]},{"hash":"1443404669684489559","title":"MAPK signaling and morphogenesis in muscle and gland","description":"This cluster centers on positive regulation of the ERK/MAPK cascade and responses to growth factors (insulin, PDGF, TGF-beta), together with processes like myoblast fusion, smooth muscle migration, and gland morphogenesis, suggesting a theme of growth-factor signaling driving developmental morphogenesis across muscle and mammary tissue.","confidence":"Medium","size":14,"edges":11,"triangles":0,"max_degree":4,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0070374","count":6},{"id":"GO:0060444","count":5},{"id":"GO:0071300","count":5},{"id":"GO:1901741","count":5},{"id":"GO:0014911","count":5}]},{"hash":"1824914656055483176","title":"Synaptic vesicle trafficking and membrane dynamics","description":"Based on the top GO terms, the proteins are enriched for regulation of synaptic vesicle endocytosis and exocytosis, together with transmembrane transport and membrane lipid homeostasis, indicating a core role in synaptic vesicle cycling and membrane dynamics. Additional terms such as Rac signaling, axon extension, and gene expression regulation may reflect broader neuronal signaling roles or shared regulatory interfaces, but the dominant theme centers on vesicle trafficking and membrane regulation in neurons.","confidence":"Medium","size":14,"edges":10,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:0071806","count":2},{"id":"GO:0000060","count":2},{"id":"GO:0055091","count":2},{"id":"GO:2000300","count":2}]},{"hash":"1152346535813762183","title":"Cardiac morphogenesis and heart development","description":"The proteins are enriched for terms tied to heart formation and structure: embryonic heart tube development, outflow tract morphogenesis, atrial/ventricular junction remodeling, ventricular and atrial septum morphogenesis, valve formation, and foramen ovale closure, with vasculogenesis also represented. These collectively point to a coherent theme of cardiac morphogenesis, with a couple of signaling terms (Rho regulation, isotype switching) that may be peripheral. Overall, the cluster appears to reflect cardiac development processes.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003294","count":2},{"id":"GO:0035050","count":2},{"id":"GO:0003151","count":2},{"id":"GO:0060412","count":2},{"id":"GO:0035922","count":2}]},{"hash":"616844769147815732","title":"Developmental morphogenesis and cytoskeletal signaling","description":"The top GO terms emphasize development across multiple tissues (lens, placenta, inner ear, heart) and processes linked to cell shape changes and movement (Rho signaling, lamellipodium assembly). A smaller set points to DNA-templated transcription. Together these terms suggest a group of proteins involved in developmental morphogenesis with cytoskeletal dynamics rather than a single pathway.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000902","count":2},{"id":"GO:0007266","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0043552","count":2}]},{"hash":"1470664497122301254","title":"Multilineage Cell Fate Determination","description":"The top GO terms cover endodermal, astrocyte, cardiac, otic vesicle, and lens/fate-related development, plus a generic DNA-templated transcription activity, indicating a broad theme of cell fate specification across multiple tissues rather than a single pathway; the lack of edges further suggests a collection of diverse developmental regulators rather than a cohesive module.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007493","count":1},{"id":"GO:0060018","count":1},{"id":"GO:0030879","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0045586","count":1}]},{"hash":"2197459165438763581","title":"Developmental signaling and cytoskeletal regulation","description":"This cluster\u2019s top GO terms cluster around developmental processes (male gonad development, skin development, multicellular organism development) while also highlighting signaling and cytoskeletal elements (autophosphorylation, tyrosine phosphorylation, GTPase regulation, and Arp2/3-mediated actin nucleation), suggesting a theme of development coupled with cytoskeletal dynamics. The terms are diverse but share a core involvement in developmentally regulated signaling and cellular architecture.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031954","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1270172120020576435","title":"Neural and cardiac development signaling","description":"The GO terms show a theme of nervous system excitability (sensory perception of pain, neuronal action potential, membrane depolarization) together with heart development signals (AV node depolarization, outflow tract morphogenesis), plus broader developmental processes like bone maturation. This suggests a cluster of proteins involved in excitable tissue signaling within developmental contexts, though some terms are less tightly connected.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0043931","count":6},{"id":"GO:0007275","count":6}]},{"hash":"322033259205672970","title":"ECM Remodeling and Vascular Maturation","description":"The cluster centers on extracellular matrix remodeling (ECM disassembly, collagen catabolic process, plasminogen activation) and vascular development (blood vessel maturation, endothelial barrier establishment). Cadherin-mediated adhesion supports tissue organization during angiogenesis. A few terms point to broader development (neuronal stem cell maintenance, cartilage growth), but the dominant signal ties ECM remodeling to vessel maturation, justifying the label as representative of the cluster\u2019s function.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097150","count":6},{"id":"GO:0022617","count":4},{"id":"GO:0001955","count":4},{"id":"GO:0030574","count":4},{"id":"GO:0044331","count":4}]},{"hash":"1080316283734011307","title":"Embryonic Development and Morphogenesis","description":"The top GO terms center on embryonic development and tissue morphogenesis across diverse tissues (mesoderm, placenta, cartilage, hair follicles, pancreas, etc.), including left-right patterning and EMT. This suggests a broad developmental/differentiation program rather than a specific functional module.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":11},{"id":"GO:0060536","count":11},{"id":"GO:0035270","count":11},{"id":"GO:0003198","count":11},{"id":"GO:0003323","count":11}]},{"hash":"775224137865785788","title":"Egg chamber follicle cell adhesion and polarity","description":"This cluster is dominated by GO terms about adhesion of follicle cells in the egg chamber and maintenance of polarity in the follicular epithelium, pointing to insect oogenesis-related processes. Although a couple of terms touch on eye development or metabolic/nitric oxide processes, the strongest signals describe epithelial adhesion and polarity in the ovarian follicle. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007299","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0001744","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0005975","count":1}]},{"hash":"933142593967050878","title":"Ubiquitin-regulated protein turnover","description":"The top GO terms show a clear emphasis on the ubiquitin-proteasome system, with ubiquitin-dependent protein catabolic process and negative regulation of protein ubiquitination as prominent annotations. While some terms touch on diverse processes (muscle development, T cell differentiation, circadian rhythms, and others), these can be influenced by ubiquitin signaling, suggesting a broad regulatory role rather than a single pathway. Overall, the cluster seems centered on ubiquitin-mediated regulation of protein fate, hence this label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0048741","count":4},{"id":"GO:0031397","count":4},{"id":"GO:0045496","count":4},{"id":"GO:0043380","count":4}]},{"hash":"93718951236317986","title":"Immune activation and growth regulation","description":"This cluster includes GO terms tied to immune functions (response to lipopolysaccharide, phagocytosis, type II interferon production, B cell differentiation) alongside growth and developmental processes (regulation of multicellular organism growth, angiogenesis, multicellular organism growth, energy homeostasis, glial cell proliferation, thymic T cell selection). The togetherness of immune signaling and growth/metabolic regulation suggests proteins that link immune responses with tissue development and metabolism.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060252","count":2},{"id":"GO:0045060","count":2},{"id":"GO:0040014","count":2},{"id":"GO:0097009","count":2},{"id":"GO:0045579","count":2}]},{"hash":"671354684766678314","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around embryonic development and tissue morphogenesis across multiple lineages (placenta/trophoblast differentiation, mesoderm development, cartilage and hair follicle morphogenesis, roof of the mouth, left-right patterning). This points to a shared role in developmental processes rather than a single tissue-specific function. Confidence in this connection is High.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0034396","count":13},{"id":"GO:0007498","count":13}]},{"hash":"2161503074837446278","title":"Embryonic Development and Morphogenesis","description":"The top GO terms are strongly centered on embryonic development and tissue morphogenesis, including placenta development, cartilage morphogenesis, endocrine system development, and left-right pattern formation, plus EMT-related heart development and trophoblast differentiation. This suggests the proteins in this cluster participate in developmental programs and tissue differentiation. A few general transcriptional regulation terms are present, likely reflecting shared regulatory roles during development, but do not override the dominant developmental/theme signal.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":14},{"id":"GO:0060536","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0003323","count":14}]},{"hash":"1350765534723594442","title":"Unknown","description":"The terms span cell migration, telomere maintenance/capping, pain detection, ephrin/GPCR signaling, and hepatocyte apoptosis, with several obsolete GO entries. This mixture lacks a single cohesive biological function that ties all proteins together, making it inappropriate to assign a specific, representative label. ","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":5},{"id":"GO:0032212","count":5},{"id":"GO:1904355","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0097284","count":4}]},{"hash":"378462746299144509","title":"Neuronal synaptic signaling and plasticity","description":"Based on the top GO terms, the cluster is enriched for glutamatergic synaptic transmission, long-term potentiation/depression, and brain development, with PI- and Rho-mediated signaling that influence cytoskeletal dynamics at synapses. These together point to neuronal communication and synaptic plasticity as the core theme. While some terms pertain to cell cycle or skin biology, the dominant pattern reflects neural signaling and plasticity, including social behavior associations. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060292","count":2},{"id":"GO:0035249","count":2},{"id":"GO:1900273","count":2}]},{"hash":"526433050771303757","title":"RNA Pol II Transcription Regulation","description":"Top GO terms point to nuclear transcription control, with DNA-templated transcription (GO:0006351) and negative regulation of transcription by RNA polymerase II (GO:0000122), supporting a transcription-regulatory cluster. Some redox and viral-process terms appear as noise, but the core signal is transcription regulation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0046826","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006662","count":2}]},{"hash":"1294789349357172331","title":"Embryogenesis and Organ Morphogenesis","description":"These GO terms point to broad embryonic development and tissue/organ morphogenesis across diverse lineages (placenta, mesoderm, cartilage, hair follicle, palate, endocrine system, pancreatic cells). The shared function is embryogenesis and organ formation, justifying a general label for morphogenesis during development.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060806","count":14},{"id":"GO:0060536","count":14},{"id":"GO:0060707","count":14},{"id":"GO:0007498","count":14},{"id":"GO:0031069","count":14}]},{"hash":"1639346441355098712","title":"Macrophage lipid remodeling and inflammatory signaling","description":"This cluster centers on macrophage lipid remodeling across multiple phospholipids (PS, PG, PC) and lipid mediator production (arachidonate, leukotrienes) combined with inflammatory outputs (IL-8) and foam cell formation, plus defense responses to bacteria. The GO terms collectively point to lipid remodeling in immune macrophages and associated inflammatory processes, including foam cell differentiation relevant to atherosclerosis.","confidence":"High","size":13,"edges":15,"triangles":4,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0090370","count":4},{"id":"GO:0010518","count":4},{"id":"GO:0032637","count":4},{"id":"GO:0036150","count":4},{"id":"GO:0036148","count":4}]},{"hash":"1739125383146266522","title":"Central carbon metabolism and biosynthesis","description":"This cluster centers on core carbon pathways (TCA cycle, glycolysis, glyoxylate cycle, 2-oxoglutarate metabolism) and includes several biosynthetic processes (biotin, porphyrinogen, and antibiotic biosynthesis), suggesting a cohesive theme of central metabolism fueling biosynthetic outputs.","confidence":"High","size":13,"edges":60,"triangles":161,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":5},{"id":"GO:0019878","count":5},{"id":"GO:0006096","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0071555","count":4}]},{"hash":"2175879865367357270","title":"Ribosome Biogenesis and Translation","description":"The proteins cluster around core ribosome-related functions: multiple GO terms for translation (GO:0006412), ribosomal large subunit assembly and biogenesis, and translational termination, including mitochondrial translation termination, plus regulation of translation. While there are occasional stress-response terms, the dominant theme is ribosome assembly and protein synthesis, suggesting this cluster represents the ribosome/translation machinery and its regulation.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0000027","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0006415","count":3},{"id":"GO:0070126","count":2}]},{"hash":"1977137776074600568","title":"Mitochondrial respiration and cytochrome c regulation","description":"The cluster is dominated by GO terms related to mitochondrial respiration and assembly of the electron transport chain (complex IV assembly, respirasome assembly, aerobic respiration) and regulation of cytochrome c release, pointing to mitochondrial energy metabolism and apoptotic control as the core theme. Additional terms about calcium transport and membrane insertion are compatible with mitochondrial-associated processes, while a few unrelated terms (root hair elongation, excitatory postsynaptic potential) appear as peripheral annotations. Overall, the pattern supports a mitochondrial respiration-centered cluster.","confidence":"High","size":13,"edges":17,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":2},{"id":"GO:0090201","count":2},{"id":"GO:0097250","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0070542","count":2}]},{"hash":"780582914146200727","title":"Spliceosome-mediated mRNA processing and export","description":"The cluster is strongly enriched for GO terms around mRNA splicing via the spliceosome, including recognition of splice sites, regulation (positive/negative) of splicing, alternative splicing, and mRNA export from the nucleus, with supporting terms on polyadenylation. This pattern points to proteins involved in mRNA maturation and nuclear export, particularly components or regulators of the spliceosome. Therefore, labeling it as spliceosome-mediated mRNA processing and export captures the core function of the cluster.","confidence":"High","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0006376","count":8},{"id":"GO:0075525","count":7},{"id":"GO:0048025","count":7}]},{"hash":"551913456831502709","title":"GPCR-driven vascular signaling and platelet activation","description":"The cluster centers on GPCR signaling that activates adenylate cyclase, with strong ties to vascular regulation (blood pressure), platelet activation, and membrane potential changes. Inflammatory responses and xenobiotic handling fit within broader vascular and immune signaling contexts, while electron transport chain and bone remodeling suggest linked metabolic and remodeling processes in these cells. Overall, the dominant theme is GPCR-mediated signaling affecting cardiovascular and platelet-related functions, with ancillary metabolic and inflammatory roles.","confidence":"Medium","size":13,"edges":5,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":5},{"id":"GO:0045777","count":5},{"id":"GO:0022900","count":5},{"id":"GO:0042493","count":4},{"id":"GO:0008284","count":4}]},{"hash":"1071101674973587481","title":"Neuronal Ion Transport and Synaptic Signaling","description":"The top GO terms cluster around neuronal signaling and ion handling: excitatory postsynaptic potential, membrane depolarization/hyperpolarization, calcium and potassium ion transport, and neuromuscular junction development. There is also amino acid export across the plasma membrane, which can relate to neurotransmitter handling. Together these terms indicate a function focused on neuronal excitability and synaptic communication, driven by calcium and other ion fluxes. A few terms like bleb assembly and bone resorption are less central but can be connected via cytoskeletal dynamics and calcium signaling, not changing the overall theme.","confidence":"High","size":13,"edges":35,"triangles":36,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0051899","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0060081","count":3},{"id":"GO:0032060","count":3}]},{"hash":"866408404429430476","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":19,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071042","count":2},{"id":"GO:0071035","count":2},{"id":"GO:0071051","count":2},{"id":"GO:0000467","count":2},{"id":"GO:0016973","count":2}]},{"hash":"2058585922480899489","title":"Keratinocyte differentiation and signaling regulation","description":"The top GO terms point to a theme of epithelial cell fate decisions and growth signaling, highlighted by keratinocyte differentiation (GO:0030216) and key pathways such as Hippo (GO:0035329) and Wnt (GO:0090263) signaling, along with negative regulation of TGF-beta receptor signaling. The inclusion of apoptotic processes and regulation of GTPase activity suggests coordinated control of proliferation, survival, and cytoskeletal dynamics relevant to epidermal homeostasis. Although some terms touch on muscle contraction and ion transport, the dominant pattern supports a cluster centered on epithelial differentiation and associated signaling networks.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0030512","count":9},{"id":"GO:0060044","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0030216","count":6},{"id":"GO:0035329","count":6}]},{"hash":"1783751060587963641","title":"Cartilage and Cardiac Development Signaling","description":"The terms center on growth plate cartilage chondrocyte differentiation and proliferation and cardiac muscle development, with a guanylyl cyclase\u2013cGMP signaling theme, suggesting a shared mesoderm-derived tissue growth/development mechanism. Obsolete terms and a few trafficking terms dilute the signal, but cartilage and heart development signals are the main pattern.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0030814","count":1},{"id":"GO:0003418","count":1},{"id":"GO:1902261","count":1},{"id":"GO:0030823","count":1}]},{"hash":"36675749153410457","title":"Hexosamine metabolism and nuclear regulation","description":"This cluster centers on hexosamine metabolism (glucosamine/GlcNAc catabolism and UDP-GlcNAc biosynthesis) and nuclear/cell-cycle processes (protein localization to nucleus and regulation of cell cycle), with a hint of signaling via STAT phosphorylation. The most coherent theme ties carbohydrate metabolism to nuclear regulation and signaling, suggesting a role in coordinating metabolic state with nuclear events. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051457","count":2},{"id":"GO:0042517","count":2},{"id":"GO:0005975","count":1},{"id":"GO:0009051","count":1},{"id":"GO:0006043","count":1}]},{"hash":"933119111469355712","title":"Mesoderm formation and muscle development signaling","description":"The terms point to a mesodermal/muscle developmental program: mesoderm formation, muscle activity responses, positive regulation of stem cell differentiation, DNA replication and cell cycle re-entry, and signaling pathways involving VEGF/PDGF and nitric oxide, together with ECM remodeling. This suggests a coordinated mesodermal lineage specification and muscle progenitor differentiation with associated proliferation and signaling dynamics.","confidence":"High","size":13,"edges":65,"triangles":165,"max_degree":12,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":13},{"id":"GO:0014850","count":13},{"id":"GO:0006351","count":13},{"id":"GO:2000738","count":13},{"id":"GO:0001707","count":13}]},{"hash":"1545074660576418274","title":"Hair cell mechanosensory development","description":"The top GO terms are dominated by mechanosensory and hair cell biology: detection of mechanical stimulus involved in sensory perception of sound, auditory receptor cell development, and posterior lateral line neuromast hair cell development. This points to a shared function in hair cell formation and mechanosensory perception, especially in neuromast/hair cells, with a few ancillary terms (redox, transcription, cardiac regulation) that don\u2019t override the main theme.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0060117","count":2},{"id":"GO:0010923","count":2},{"id":"GO:0035677","count":2},{"id":"GO:0051775","count":2}]},{"hash":"432755649327458402","title":"Nuclear transport and transcription regulation","description":"The top GO terms point to nuclear functions: ribosomal subunit export from the nucleus, nuclear pore complex assembly, and transcription-related terms (RNA Pol II\u2013mediated regulation, DNA-templated transcription, and mitochondrial transcription regulation). Additional RNA modification and methylation terms align with nuclear RNA processing activities, while a xenobiotic response suggests broader regulatory involvement. Overall, the cluster appears centered on nuclear transport and transcription-related regulation, with some related RNA processing features.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0006656","count":2},{"id":"GO:0000056","count":2},{"id":"GO:0051292","count":2},{"id":"GO:0032259","count":1}]},{"hash":"754535724817839279","title":"Unknown","description":"The terms span plant development (root cap development, inflorescence meristem growth) and vertebrate immune processes (isotype switching, IgG regulation) plus general cellular processes (iron transport, endocytosis). There is no single cohesive function tying these terms together, so there is no reliable cluster label beyond Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048829","count":2},{"id":"GO:0045190","count":2},{"id":"GO:0048304","count":2},{"id":"GO:0007039","count":1},{"id":"GO:0098707","count":1}]},{"hash":"2141510873879201684","title":"Neural development and junctional signaling","description":"These proteins show strong enrichment for neural-related processes: paranodal junction assembly, transmission of nerve impulse, nervous system development, and homophilic cell\u2013cell adhesion, pointing to roles in neural development and axon\u2013glial junctions. Lipid remodeling terms may reflect membrane changes in myelin or synaptic membranes, while immunoglobulin production likely captures Ig-like adhesion molecules in neural tissues. Overall, the cluster centers on neural development and junctional signaling.","confidence":"Medium","size":13,"edges":44,"triangles":59,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":5},{"id":"GO:0019226","count":4},{"id":"GO:0002377","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0042511","count":4}]},{"hash":"1318985456488092672","title":"Cytoskeleton-Related Adhesion and Muscle Attachment","description":"The cluster shows a pattern of cytoskeletal dynamics (microtubule plus/minus-end localization, actin-related terms) and muscle-related functions (muscle attachment, regulation of skeletal muscle contraction via calcium), with some adhesion terms (heterotypic cell-cell adhesion). While a few terms are unrelated or obsolete, the dominant theme centers on cytoskeleton organization and muscle/adhesion processes, justifying this label.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000742","count":4},{"id":"GO:0034113","count":4},{"id":"GO:1904519","count":3},{"id":"GO:0071670","count":3},{"id":"GO:0014809","count":3}]},{"hash":"1709708593198916207","title":"Endochondral ossification and hormone response","description":"The dominant terms point to bone formation, especially endochondral ossification and cementum mineralization, with responses to vitamin D and thyroid hormone indicating hormonal regulation of skeletal development. Additional terms on transcriptional regulation and redox/homeostasis suggest regulatory and metabolic support during differentiation.","confidence":"Medium","size":13,"edges":14,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:1903026","count":2},{"id":"GO:0097067","count":2},{"id":"GO:0071529","count":1},{"id":"GO:0033280","count":1}]},{"hash":"2254873236423615585","title":"Calcium-Dependent Neuronal Signaling and Stress Response","description":"This cluster centers on calcium-dependent pathways (calcineurin-NFAT), neuronal activity and photoreceptor morphogenesis, and related signaling components (potassium channel clustering, membrane dynamics). Additional terms indicate broader stress and transcriptional regulation roles, suggesting a module where calcium signaling governs neuronal/sensory function and responses to stress or xenobiotics.","confidence":"Medium","size":13,"edges":45,"triangles":77,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035191","count":9},{"id":"GO:0043950","count":9},{"id":"GO:0014850","count":9},{"id":"GO:0033173","count":9},{"id":"GO:0033555","count":9}]},{"hash":"972277891460364695","title":"Glycosylation and glycan metabolism","description":"This cluster is dominated by glycan-related processes: N-linked glycosylation via asparagine (obsolete term), N-glycan processing, protein sialylation, glycosylceramide metabolic process, and N-acetylneuraminate metabolic process, suggesting a core theme of glycosylation and glycan metabolism. The other terms (sensory pain and temperature perception) are present but appear ancillary rather than defining the group\u2019s primary function.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0006677","count":4},{"id":"GO:1990743","count":4}]},{"hash":"1992822235595834526","title":"Ubiquitin-mediated regulation of signaling and turnover","description":"The cluster centers on ubiquitin-related processes: ubiquitin-dependent protein catabolic process and autoubiquitination, with links to regulation of transcription, apoptosis/necroptosis, TLR signaling, and receptor turnover (Wnt receptor catabolic process). The inclusion of peroxisomal protein import (which involves ubiquitination cycles) further supports a unifying theme where ubiquitin controls protein stability and diverse signaling pathways, including growth and dosage-related regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":4},{"id":"GO:1900095","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0034121","count":4}]},{"hash":"2192308105147303057","title":"Unknown","description":"The GO terms span neural development (dendrite self-avoidance, sensory perception of sound), organogenesis (organ induction, metanephric mesenchymal cell migration), KIT signaling and potassium channel clustering, and immune signaling, with no single dominant theme tying them together.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0002729","count":1},{"id":"GO:1903082","count":1},{"id":"GO:0048671","count":1},{"id":"GO:0070593","count":1}]},{"hash":"1365833993783664441","title":"Neural-immune signaling and development","description":"Enriched terms include paranodal junction assembly, Notch and integrin signaling, and microglia and photoreceptor development, pointing to a cluster of proteins involved in neural development and neural-immune signaling. The presence of cell surface receptor signaling and lysosome localization supports a theme of receptor-mediated communication and trafficking in neural tissues, with a broader note on receptor-mediated viral entry.","confidence":"Medium","size":13,"edges":10,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":5},{"id":"GO:0007166","count":5},{"id":"GO:0045747","count":5},{"id":"GO:0071404","count":5},{"id":"GO:2001046","count":5}]},{"hash":"2221700327566769938","title":"Unknown","description":"The top GO terms show immune defense (virus response, LPS signaling, dendritic cell differentiation), RNA processing (mRNA decay, siRNA processing), and several unrelated terms (cell cycle, cardiac development, nitrogen regulation). This spread indicates no single shared function dominates the cluster.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0043011","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0007050","count":2}]},{"hash":"1321119239469602713","title":"Developmental signaling and organogenesis","description":"The top GO terms cluster around developmental processes across tissues (organ induction, metanephric mesenchyme migration, ossification, spermatid and auditory receptor development) and signaling pathways (KIT, CCR7, VEGF/PDGF signaling) that regulate proliferation and differentiation. This suggests a common theme of signaling directing development and organ formation rather than a single specific function, justifying a label focused on development and organogenesis.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002729","count":2},{"id":"GO:1903082","count":2},{"id":"GO:0038109","count":2},{"id":"GO:0035234","count":2},{"id":"GO:0001759","count":2}]},{"hash":"1930235204617204840","title":"Immune signaling and cytoskeletal dynamics","description":"The top GO terms cluster around immune cell signaling and differentiation (B cell affinity maturation, NK T cell differentiation, cellular response to IL-7, negative regulation of neutrophil degranulation) combined with cytoskeletal remodeling (actin cytoskeleton organization, activation of GTPase) and cell migration, suggesting a theme of immune signaling linked to cytoskeleton-driven movement. Some terms like midbrain morphogenesis and insulin receptor signaling are less central but do not negate the overall immune/cytoskeletal theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904693","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0002344","count":3},{"id":"GO:0098761","count":3},{"id":"GO:0016477","count":3}]},{"hash":"69646187419719393","title":"Embryogenesis and tissue morphogenesis","description":"The top GO terms cluster around development and differentiation during embryogenesis\u2014placental/trophoblast differentiation, left-right patterning, EMT in heart development, cartilage morphogenesis, and endocrine pancreatic development\u2014with supporting terms on RNA processing and transcription regulation that commonly accompany developmental programs. This suggests a cohesive theme of embryonic development and tissue morphogenesis.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0060972","count":13},{"id":"GO:0000055","count":13}]},{"hash":"2176651556582428980","title":"ER-Golgi vesicle transport","description":"This cluster shows explicit enrichment for vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus (ER-to-Golgi and intra-Golgi vesicle transport), pointing to a secretory pathway role. Other terms (e.g., brain development, transcription antitermination, snoRNP assembly) appear more incidental noise relative to the transport terms, so the transport theme is the most representative signal. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031564","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0021756","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0021794","count":2}]},{"hash":"81289135944119015","title":"Vacuolar ion transport and acidification","description":"This cluster is dominated by terms related to proton and ion transport across membranes, vacuolar organization and acidification, and targeting to the vacuole, suggesting a cohesive role in vacuolar ion homeostasis and proton motive force\u2013driven processes, with some additional links to Golgi Ca2+ handling and mitochondrial targeting that may reflect broader secretory pathway maintenance.","confidence":"High","size":12,"edges":22,"triangles":12,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":6},{"id":"GO:0010248","count":4},{"id":"GO:0007033","count":3},{"id":"GO:0006814","count":3},{"id":"GO:0006626","count":3}]},{"hash":"1577924540178224025","title":"Mitochondrial electron transport and apoptosis","description":"Proteins in this cluster are dominated by terms linking mitochondrial electron transport (ubiquinol to cytochrome c; cytochrome c to oxygen) with apoptotic processes and cytochrome c\u2013related activity, plus ROS-related (hydrogen peroxide) and plant context terms (photosynthesis). This points to a theme of mitochondria-centered respiration and programmed cell death signaling, with ROS as a modulatory factor, making the label representative of the cluster\u2019s core function.","confidence":"High","size":12,"edges":22,"triangles":8,"max_degree":7,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0008635","count":4},{"id":"GO:0034465","count":4},{"id":"GO:0042743","count":4},{"id":"GO:0015979","count":4}]},{"hash":"1265650634323289053","title":"TLR/MyD88-Driven Innate Immune Signaling","description":"The cluster centers on innate immune signaling via Toll-like receptors, especially MyD88-dependent pathways, with detection of diacyl lipopeptides and IL-8 production, plus regulation of receptor signaling and kinase activity. Some vascular and neural terms appear but do not outweigh the core immune signaling theme.","confidence":"High","size":12,"edges":21,"triangles":12,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006469","count":11},{"id":"GO:0045416","count":10},{"id":"GO:0010596","count":10},{"id":"GO:0016525","count":10},{"id":"GO:1903351","count":10}]},{"hash":"1509852855741944412","title":"Mitochondrial fatty acid oxidation","description":"The cluster is enriched for GO terms tied to mitochondrial lipid metabolism, notably carnitine metabolic process and fatty acid beta-oxidation, plus long-chain fatty acid transport and mitochondrial translation. These collectively point to mitochondria-centric energy production from fatty acids as a shared theme among the proteins. Some terms (N-glycan processing, acetylcholine biosynthesis, ovarian follicle growth, heart development, hypoxia response) are broader or context-specific processes that can occur in tissues with high energy demand; they don't contradict the central metabolic theme but are less specific to fatty acid oxidation. Overall, the dominant signal supports a mitochondrially focused fatty acid metabolism cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019254","count":2},{"id":"GO:0033540","count":2},{"id":"GO:0006491","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0071456","count":2}]},{"hash":"521554330257337399","title":"Unknown","description":"The terms cover a mix of retina development, immune cell proliferation, serine/cysteine metabolism including transsulfuration and hydrogen sulfide production, general signaling, glucose starvation response, nuclear import, and cell cycle regulation. There isn\u2019t a single cohesive theme connecting these terms, suggesting diverse or pleiotropic roles rather than a defined cluster function, so a specific, meaningful label isn\u2019t justifiable from the provided data.","confidence":"","size":12,"edges":63,"triangles":193,"max_degree":11,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0060041","count":6},{"id":"GO:0046651","count":6},{"id":"GO:0006565","count":6},{"id":"GO:0032147","count":6},{"id":"GO:0019346","count":6}]},{"hash":"748134896982410434","title":"ER stress and glutamatergic synaptic signaling","description":"The cluster features ER proteostasis/ERAD related terms (ER overload response, endoplasmic reticulum organization, ubiquitin-dependent ERAD) alongside neuronal/synaptic terms (glutamatergic transmission, synapse assembly, excitatory postsynaptic potential, vocalization and grooming behavior), suggesting a link between ER stress responses and synaptic function. Some terms (osteoblast differentiation) may be noise or pleiotropy, but the core pattern supports ER stress\u2013synaptic signaling as the theme.","confidence":"Medium","size":12,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0001649","count":2},{"id":"GO:0006983","count":2},{"id":"GO:0007029","count":2},{"id":"GO:2000463","count":2}]},{"hash":"1962675020534425650","title":"Regulators of signaling and development","description":"The cluster shows GO terms across multiple regulatory pathways and developmental processes (PDGF receptor signaling, PI3K/Akt signaling, innate immune response, endothelial and cardiac development, mesoderm formation, pancreatic development, and B cell receptor signaling). This diversity suggests proteins that broadly modulate signaling and development rather than a single, cohesive function. Therefore a broad label focused on regulatory roles in signaling and development is most appropriate.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010641","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0032298","count":3}]},{"hash":"749785360579312574","title":"Developmental Gene Regulation and Differentiation","description":"Based on the Top Terms, the cluster centers on developmental processes (multicellular organism development, mesoderm formation, stem cell differentiation) and the underlying gene expression control (DNA-templated transcription, nucleosome disassembly, mRNA export). The presence of signaling (insulin receptor signaling) and muscle activity response suggests coordination between growth, metabolism, and tissue differentiation. Thus the label Developmental Gene Regulation and Differentiation captures the main theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0006337","count":2},{"id":"GO:0006406","count":2}]},{"hash":"497025281979412039","title":"Dendrite and Synapse Development","description":"The terms center on dendritic spine morphogenesis, dendrite development, and receptor localization to synapse plus postsynaptic potential regulation, indicating a focus on neuronal morphogenesis and synaptic targeting. Some terms (germ cell death, renal transport, exploration and vocalization behaviors) are less specific but can reflect broader neural development and behavior contexts, so the cluster most plausibly groups proteins involved in neuronal connectivity and synaptic organization.","confidence":"Medium","size":12,"edges":23,"triangles":16,"max_degree":10,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0060997","count":8},{"id":"GO:2000463","count":7},{"id":"GO:0035234","count":7},{"id":"GO:0016358","count":7},{"id":"GO:0097120","count":7}]},{"hash":"535195370199244869","title":"Cell adhesion and tissue regeneration","description":"The cluster is enriched in GO terms for cell adhesion (cell adhesion, heterophilic and homophilic interactions) and positive regulation of cell-matrix adhesion, plus tissue regeneration, suggesting a role in adhesion-driven tissue repair or development. The hyaloid vascular plexus regression term hints at developmental ocular vascular remodeling. A couple of terms related to translation and transcriptional regulation are present but do not override the central theme of cell\u2013cell/matrix adhesion and regenerative processes.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0001954","count":2},{"id":"GO:0042246","count":2},{"id":"GO:1990384","count":2},{"id":"GO:0007155","count":2}]},{"hash":"110487961282458331","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning RNA processing/translation regulation (mRNA stability, cap-independent initiation, polyadenylation) and epithelial/barrier-related processes (basolateral membrane localization, tight junction/microvillus assembly, intestinal barrier), plus plant defense and developmental terms. There isn't a single coherent function tying the proteins together, so a confident, specific label cannot be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034052","count":2},{"id":"GO:1903679","count":2},{"id":"GO:0043488","count":2},{"id":"GO:0044829","count":2},{"id":"GO:1900363","count":2}]},{"hash":"1931568045028019707","title":"Neuronal Development and Synaptic Function","description":"The most frequent GO terms describe nervous system development and neural activity\u2014axonogenesis, Schwann cell development, and visual perception\u2014indicating these proteins likely participate in neural development and function. Excitatory postsynaptic potential supports synaptic signaling. While redox homeostasis, cell cycle, angiogenesis, and heart development appear, they are less central to the cluster\u2019s dominant neural theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045454","count":5},{"id":"GO:0014044","count":3},{"id":"GO:0000086","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0007601","count":3}]},{"hash":"2116290700590979686","title":"ER and Mitochondrial Stress and Protein Homeostasis","description":"This cluster is enriched for GO terms related to ER stress response (negative regulation of ER stress-induced apoptotic signaling; tail-anchored membrane protein insertion into ER membrane), protein quality control and synthesis (nucleotide-excision repair; negative regulation of proteasomal protein catabolic process; ribosomal small subunit assembly), organelle dynamics (positive regulation of mitochondrial fusion) and calcium signaling (negative regulation of store-operated calcium channel activity). The pattern centers on cellular stress management and maintenance of protein and organelle function involving the ER and mitochondria, with some broader stress-related terms included. ","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":6},{"id":"GO:0006289","count":6},{"id":"GO:1901799","count":6},{"id":"GO:0017085","count":6},{"id":"GO:0000028","count":6}]},{"hash":"110905434745386906","title":"Planar polarity and axon guidance","description":"Top terms converge on planar cell polarity signaling and its role in directing neuron axon guidance and tissue organization (hair orientation, lung morphogenesis, and related polarity protein localization), with dopaminergic/serotonergic axon guidance supporting neural pathfinding. A couple of terms (mRNA splicing via spliceosome, retina development) are less central but can be connected to broader developmental programs. Overall, the cluster seems to reflect PCP-related polarity cues coupled to axon guidance during development.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0060041","count":2},{"id":"GO:1904938","count":2},{"id":"GO:0048105","count":2},{"id":"GO:0060489","count":2}]},{"hash":"2195963435473851974","title":"Transcription Regulation and Cell Cycle Stress Response","description":"The top GO terms point to transcriptional control (DNA-templated transcription, negative regulation of RNA Pol II) as a core function, with concurrent signals of cellular stress response (ER unfolded protein response, autophagy via ULK1) and cell cycle dynamics (mitotic checkpoints, spindle pole separation, re-entry into the cell cycle). Although some development-related terms appear, the dominant themes center on transcription regulation coupled with cell cycle and stress-response pathways, suggesting a coordinated regulation of gene expression during growth under stress. ","confidence":"Medium","size":12,"edges":42,"triangles":76,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0030968","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0060749","count":4}]},{"hash":"2152415241280352516","title":"Cardiac and Retinal Morphogenesis Signaling","description":"The cluster is enriched for tissue morphogenesis terms in heart and retina (ventricular cardiac muscle tissue morphogenesis and photoreceptor cell morphogenesis), alongside calcium-dependent signaling (calcineurin-NFAT cascade) and GTPase regulation, with membrane remodeling and potassium channel organization. This combination points to signaling pathways governing development and maturation of excitable tissues like heart and retina, making a morphogenesis-focused label appropriate.","confidence":"High","size":12,"edges":52,"triangles":117,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":12},{"id":"GO:0035191","count":11},{"id":"GO:0043950","count":11},{"id":"GO:1903525","count":11},{"id":"GO:0033173","count":11}]},{"hash":"1257245790824459343","title":"Immune-ECM Interaction and Cell Adhesion","description":"The top GO terms show a blend of immune signaling (adaptive immune response, T cell proliferation, NF-kappaB regulation) with extracellular matrix and cell adhesion processes (ECM organization, receptor clustering, heterophilic cell\u2013cell adhesion, symbiont entry into host cell). This suggests a theme centered on how immune signals interface with the extracellular environment and cell adhesion, with a few developmental annotations as possible broader contextual terms. Therefore, label: Immune-ECM Interaction and Cell Adhesion.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0042102","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0046718","count":2}]},{"hash":"628710679822530969","title":"Mitotic Cell Cycle Core Regulation","description":"The group is enriched for mitosis-related GO terms (spindle pole body duplication, G2/M transition, and cell cycle) with associated phosphorylation and DNA binding regulation, indicating a core role in cell division; several other terms reflect broader development or signaling annotations that may be incidental.","confidence":"Medium","size":12,"edges":14,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1903087","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0000086","count":3}]},{"hash":"1957422286853075518","title":"Immune signaling and actin dynamics","description":"The terms point to immune-related functions (adaptive immune response, phagocytosis) alongside cytoskeletal regulation (barbed-end actin filament capping, positive regulation of GTPase activity, tyrosine phosphorylation) and signaling (calcium transport, TGF-beta response). This suggests a theme where immune signaling is coordinated with actin remodeling and endocytic processes, even though there are no detected edges in the cluster. Confidence in this cohesive theme is moderate.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0099132","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0006909","count":2},{"id":"GO:0070588","count":2},{"id":"GO:0002250","count":2}]},{"hash":"1028120655726994091","title":"Rho GTPase-driven cytoskeleton remodeling and endocytosis","description":"These proteins cluster around Rho family GTPase signaling and actin dynamics (filopodium assembly, cell spreading, regulation of filopodium assembly) and membrane trafficking (clathrin-dependent endocytosis, GPCR internalization). The presence of small GTPase\u2013mediated signaling, actin remodeling, and endocytic processes suggests a coherent theme of cytoskeleton control coordinating vesicle internalization, with mitochondrial fission appearing as a lesser, potentially shared GTPase-associated feature. High","confidence":"","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:1900026","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0051932","count":4},{"id":"GO:0046847","count":4}]},{"hash":"25112571241257073","title":"Neural development and synapse assembly","description":"This cluster is dominated by GO terms tied to nervous system development and synapse formation (positive regulation of synapse assembly, nervous system development, sensory perception of sound). Cell adhesion terms (homophilic/heterophilic) further support neural connectivity. A few terms mention heart/bone development, but the strongest signal reflects neural development and synapse assembly.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":10},{"id":"GO:0043931","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0007157","count":9},{"id":"GO:0007156","count":9}]},{"hash":"969423795820949568","title":"Adaptive immune activation and B cell maturation","description":"The cluster\u2019s top GO terms are strongly dominated by adaptive immunity (adaptive immune response, B cell affinity maturation, IL-2 production), indicating a focus on lymphocyte activation and signaling. Additional terms point to broader signaling regulation (JNK, Rho pathways, ubiquitination) and some developmental processes, suggesting the proteins included may participate in immune signaling with supportive roles in cell fate decisions and tissue remodeling. Overall, the label reflects a cohesive theme around immune activation and B cell\u2013related maturation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":4},{"id":"GO:0046328","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0002344","count":3},{"id":"GO:0060444","count":3}]},{"hash":"1305552523570098575","title":"Developmental signaling and morphogenesis","description":"Based on the top GO terms, the proteins appear enriched for developmental signaling and morphogenesis, including ERK1/ERK2 cascade (MAPK signaling) and broader development terms (multicellular organism development, skin development, pollen/anther formation). The presence of ectodomain proteolysis regulation also ties to signaling modulation. While some metabolism terms are present, the dominant pattern points to roles in signaling-driven development across tissues, justifying a developmental signaling label.","confidence":"Medium","size":12,"edges":64,"triangles":201,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0051044","count":4},{"id":"GO:0070371","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0050901","count":3}]},{"hash":"1121883538289708138","title":"Neural development and synapse assembly","description":"The cluster shows multiple GO terms tied to nervous system development, regulation of synapse assembly, and paranodal junction assembly, along with positive regulation of sodium ion transport, suggesting a core theme of neural development and synaptic wiring. While there are broader developmental terms and some immune-related terms present, the strongest recurring annotations center on neural development and synaptic organization.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0051963","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0010765","count":4},{"id":"GO:0045087","count":4}]},{"hash":"91047131218303124","title":"Spliceosome-Mediated mRNA Processing","description":"The top GO terms are dominated by spliceosome-associated processes, including negative/positive regulation of mRNA splicing via spliceosome and alternative mRNA splicing via spliceosome, along with mRNA export from nucleus and translation preinitiation complex formation. This points to a core function in RNA processing and mRNA maturation/export, with a few other terms (glucose/cadmium response, development) offering context rather than defining the main theme. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0075525","count":1},{"id":"GO:0048025","count":1},{"id":"GO:0001825","count":1}]},{"hash":"1146584959417521294","title":"Carbohydrate catabolic pathways","description":"The cluster is dominated by GO terms for sugar metabolism and catabolism across multiple pathways (D-xylose, L-arabinose, rhamnose, D-gluconate, glycerol) and related steps like carbohydrate phosphorylation and glycerol catabolic processes, suggesting proteins involved in carbohydrate utilization and energy production. Quorum sensing is also listed but appears secondary to the main sugar-catabolism theme, supporting a cohesive \"carbohydrate metabolism\" cluster.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":3},{"id":"GO:0016049","count":2},{"id":"GO:0042732","count":2},{"id":"GO:0046167","count":2},{"id":"GO:0019521","count":2}]},{"hash":"786360835616727144","title":"Diverse Solute Transporters","description":"These proteins collectively map to a broad set of transmembrane transport activities, spanning ions (Na+, K+), vitamins, sugars, xenobiotics, and other substrates, plus a specific process for neurotransmitter loading into synaptic vesicles. The common theme is membrane transport of diverse solutes rather than a single substrate class, so a label emphasizing \u201cdiverse solute transmembrane transport\u201d fits best.","confidence":"Medium","size":12,"edges":15,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0071805","count":3}]},{"hash":"804027425311223014","title":"Neuronal vesicle trafficking and secretion","description":"The GO terms point to synaptic vesicle exocytosis, neurotransmitter secretion, and regulation of neurotransmitter release, along with multiple vesicle-transport steps between the ER and Golgi and within the Golgi apparatus. This combination strongly suggests proteins coordinating secretory vesicle formation, trafficking, and fusion in neurons (and related secretory pathways such as insulin secretion). ","confidence":"High","size":12,"edges":24,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0016079","count":5},{"id":"GO:0030073","count":4},{"id":"GO:0046928","count":4},{"id":"GO:0031915","count":4},{"id":"GO:0006836","count":4}]},{"hash":"2282570850122027439","title":"Developmental signaling and tissue differentiation","description":"The top terms cluster around broad developmental programs across multiple tissues\u2014neural development (ventricular zone neuroblast division, PNS development), vascular/angiogenic signaling (VEGF/PDGF pathway, endothelial chemotaxis), muscle and skeletal differentiation, Hedgehog signaling (Smoothened), and sensory/ mechanotransduction processes. This suggests a cohesive theme of growth and differentiation signaling guiding tissue development.","confidence":"Medium","size":12,"edges":8,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0038091","count":5},{"id":"GO:0043031","count":5},{"id":"GO:0021847","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0050910","count":5}]},{"hash":"1549789866049839351","title":"Developmental Morphogenesis and Signaling","description":"The top GO terms cluster around coronary artery morphogenesis, multicellular organism development, ossification, and regulation of TGF-beta signaling and MAPK activity, suggesting proteins involved in developmental tissue morphogenesis and signaling pathways guiding vascular and bone formation. While terms like innate immune response and unfolded protein response hint at general cellular stress, the dominant pattern is developmental morphogenesis and related signaling.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060982","count":4},{"id":"GO:0010811","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0000187","count":4},{"id":"GO:0006986","count":4}]},{"hash":"838441707450577386","title":"Skeletal development and hematopoietic signaling","description":"Most terms center on development of the skeletal system (cranial skeleton morphogenesis, skeletal system development) and signals that regulate hematopoietic/pigment cell lineages (KIT signaling, myeloid progenitor differentiation, melanocyte migration), along with related growth factor pathways (VEGF/PDGFR, FGFR signaling) and vitamin D3 metabolism. ","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0038109","count":2},{"id":"GO:0038091","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0097350","count":2},{"id":"GO:0002318","count":2}]},{"hash":"1433139267946665195","title":"Developmental organogenesis","description":"The top GO terms cluster around organ development across multiple tissues (heart development, EMT in endocardial cushion, kidney development, uterine gland development), suggesting a theme of organogenesis and morphogenesis driven by transcriptional regulation (DNA-templated transcription). Some terms appear unrelated or noisy (thylakoid membrane organization, obsolete methylation regulation, sensory perception of sound), but the core signal points to developmental processes and transcriptional control shaping organ formation.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0072218","count":2}]},{"hash":"1210410632772317499","title":"Developmental Morphogenesis and Differentiation","description":"The top GO terms point to developmental and morphogenetic processes across multiple tissues (pericardium morphogenesis, bud elongation in lung branching, embryonic liver development, pancreatic cell development) and differentiation (regulatory T cell differentiation, neuronal synaptic organization). The absence of strong, shared molecular interactions suggests a broad theme rather than a single pathway, so a label centered on development and differentiation best summarizes the cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0043552","count":3},{"id":"GO:0003344","count":3},{"id":"GO:0060449","count":3},{"id":"GO:0003323","count":3}]},{"hash":"219663976609508066","title":"Gram-positive bacterial defense and TLR2-driven inflammation","description":"These proteins are linked by innate immune responses to Gram-positive bacteria, including defense against such bacteria, TLR2 signaling, and upregulation of inflammatory cytokines (IL-6, IL-8, TNF, IL-1\u03b2). The terms also cover general detection of bacteria and pro-inflammatory regulation, supporting a cohesive theme of Gram-positive detection and cytokine-mediated inflammation, with TLR2 as a central pathway. dsRNA response may reflect broader pathogen recognition but does not override the dominant Gram-positive/inflammatory pattern.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0050729","count":3},{"id":"GO:0045416","count":3},{"id":"GO:0032755","count":3},{"id":"GO:0002830","count":3}]},{"hash":"1091615598603319384","title":"Methylation and peptide modification enzymes","description":"The top terms point to multiple modification-related processes: tRNA methylation; various N-terminal peptidyl methylation activities; and peptidyl-arginine hydroxylation, indicating a core theme of biomolecule modification. The presence of antibiotic and biotin biosynthetic processes, plus selenium metabolism, suggests these enzymes participate in diverse biosynthetic and metabolic pathways that often rely on methyltransferases and related modifying enzymes. Additionally, xenobiotic and cocaine responses align with detox-related metabolism, which can involve modification enzymes. Together, these terms cluster around enzymes that modify biomolecules and participate in related biosynthetic/metabolic functions. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0030488","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0001887","count":2},{"id":"GO:0042220","count":2}]},{"hash":"506077758819153822","title":"GTPase-regulated signaling cluster","description":"The top GO terms point to intracellular signaling networks: positive regulation of GTPase activity, phosphatidylinositol-mediated signaling, and Wnt/calcium signaling, indicating a cohesive theme of signal transduction regulated by GTPases and lipid signaling pathways. Some terms are obsolete or peripheral (metabolic or chromatin-related), but the core enrichment centers on signaling rather than metabolism or differentiation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0010873","count":2},{"id":"GO:0032782","count":2},{"id":"GO:0008211","count":2},{"id":"GO:0007223","count":2}]},{"hash":"637120076859055665","title":"Cell Cycle and Transcriptional Regulation","description":"The cluster prominently features terms tied to cell proliferation and mitosis (positive regulation of cell population proliferation; mitotic cell cycle) and transcriptional control (DNA-templated transcription; mRNA transport), complemented by signaling activities (kinase and GTPase regulation). This points to a coherent module coordinating cell cycle progression with transcriptional and signaling regulation, with an additional link to hypoxia response.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035948","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1969168045871769084","title":"Insulin signaling and metabolic regulation","description":"This cluster is dominated by GO terms for insulin receptor and IGF receptor signaling, along with regulation of glycogen synthesis, fatty acid oxidation, and glucose import in response to insulin, indicating a group of proteins involved in insulin-driven energy metabolism. Some autophagy-related terms are present but secondary to the metabolic theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":2},{"id":"GO:0045725","count":2},{"id":"GO:0032000","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0010748","count":2}]},{"hash":"2196357026595992413","title":"Developmental Morphogenesis Across Tissues","description":"This cluster is dominated by GO terms for mesoderm development, morphogenesis of hair follicles, palate/ridge formation, cartilage development, and trophoblast differentiation, indicating a shared theme of tissue development and morphogenesis across multiple lineages. Some broader cellular processes (splicing, ribosomal export, DNA replication initiation) appear but do not define the cluster\u2019s primary function; the developmental/morphogenetic pattern is still the strongest signal.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007498","count":12},{"id":"GO:0031069","count":12},{"id":"GO:0060021","count":12},{"id":"GO:0000055","count":12},{"id":"GO:0000398","count":12}]},{"hash":"503964858902205046","title":"Multisubstrate membrane transporters","description":"The top GO terms point to diverse transmembrane transport activities across sugars, nitrite/nitrate, xenobiotics, and other substrates, including vesicle-associated transport. This suggests the cluster comprises transporter proteins with broad substrate specificity rather than a single ligand, representing a general membrane transport function.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0015757","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0043252","count":2}]},{"hash":"1311953647746820199","title":"Bacterial energy metabolism with quinone biosynthesis","description":"The cluster\u2019s top GO terms cluster around central carbon metabolism (glycolysis, TCA cycle), energy-related processes (fatty acid beta-oxidation), and quinone biosynthesis (menaquinone, phylloquinone), plus various catabolic routes and xenobiotic response. This points to a coherent theme of energy production and quinone-related electron transport, with supporting metabolic diversity including antibiotic biosynthesis. ","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0006635","count":7},{"id":"GO:0009234","count":7},{"id":"GO:0010124","count":7},{"id":"GO:0042372","count":7}]},{"hash":"1534716126785903018","title":"Vision and neural signaling","description":"This cluster is enriched for terms related to the visual system and neuronal communication: phototransduction and visual perception, along with neurotransmitter secretion and signaling regulation. While there are a few terms tied to platelet biology, bone, and cardiac hypertrophy, the strongest shared theme among the top terms is eye-related sensory signaling and neuronal communication, suggesting the proteins may function in vision and neural signaling pathways.","confidence":"Medium","size":11,"edges":26,"triangles":22,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0071902","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0002576","count":2}]},{"hash":"1017543434736250323","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0034476","count":11},{"id":"GO:0006268","count":11},{"id":"GO:0000390","count":11},{"id":"GO:0035640","count":11},{"id":"GO:0034475","count":11}]},{"hash":"578398534737715640","title":"RNA processing and translation initiation","description":"The cluster\u2019s top GO terms cluster around RNA maturation and processing\u2014especially splicing regulation (positive/negative, alternative splicing), and mRNA export/stabilization\u2014alongside components linked to translation initiation and ribosome biogenesis (small-subunit processome). This suggests a cohesive group involved in RNA maturation and the early stages of translation.","confidence":"High","size":11,"edges":22,"triangles":14,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":5},{"id":"GO:0048025","count":5},{"id":"GO:0001825","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0048026","count":5}]},{"hash":"886341923234057079","title":"Oogenesis RNA processing and oskar localization","description":"The terms cluster around RNA processing and translation regulation in oocyte development, notably splicing regulation via the spliceosome and the formation of translation initiation complexes, paired with oocyte-specific cues like oskar mRNA localization to pole plasm and dorsal/ventral axis specification. This points to a cohesive theme of RNA processing and translation control during oogenesis and early embryo patterning, rather than a general cellular process. ","confidence":"Medium","size":11,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0075525","count":1},{"id":"GO:0048025","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0045451","count":1}]},{"hash":"1180129230537195164","title":"Skeletal muscle development and ubiquitin turnover","description":"The cluster\u2019s top GO terms prominently point to skeletal muscle fiber development (GO:0048741) and ubiquitin-related processes (GO:0042787 ubiquitin-dependent protein catabolic process; GO:0031397 negative regulation of protein ubiquitination). This suggests a common theme around muscle differentiation coupled with regulation of protein stability, consistent with muscle-specific growth and remodeling requiring controlled protein turnover. Some terms (e.g., memory T cell differentiation, renal sodium absorption) are less coherent with this theme, likely reflecting broader or pleiotropic annotations, but the muscle- and ubiquitin-related signals are the strongest. ","confidence":"Medium","size":11,"edges":9,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0045496","count":2},{"id":"GO:0043380","count":2}]},{"hash":"859082386982627193","title":"Cytokine- and growth-factor signaling regulation","description":"This cluster centers on modulation of multiple signaling pathways by cytokines and growth factors, including TGF-beta and IL-7 responses, IL-4 production, IGF receptor signaling, Wnt signaling, calcium-mediated signaling, insulin secretion, and negative regulation of Ras signaling and osteoclast differentiation. The terms point to a cohesive theme of regulatory signaling networks across immune, metabolic, and bone-remodeling contexts, rather than a single linear pathway.","confidence":"Medium","size":11,"edges":39,"triangles":77,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":8},{"id":"GO:0098761","count":7},{"id":"GO:0045671","count":7},{"id":"GO:0090263","count":7},{"id":"GO:0046580","count":7}]},{"hash":"373696754565387144","title":"Cardiac conduction and ion transport","description":"This cluster's top GO terms are dominated by cardiac electrical activity\u2014AV node action potential, regulation of ventricular and atrial membrane repolarization/depolarization, and heart rate regulation via cardiac conduction\u2014alongside ion transport themes such as calcium import and manganese transport. These collectively point to roles in cardiac electrophysiology and ion channel function, with ossification and development terms likely representing ancillary or shared processes. ","confidence":"Medium","size":11,"edges":12,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":8},{"id":"GO:0086016","count":7},{"id":"GO:0060307","count":7},{"id":"GO:0086091","count":7},{"id":"GO:0060371","count":7}]},{"hash":"696756303879531432","title":"Developmental transcriptional regulators","description":"The cluster is enriched for core transcriptional terms (RNA polymerase II\u2013mediated transcription and its negative regulation) alongside broad developmental processes across several organs (pancreas, hypothalamus, habenula, skeletal muscle, palate, and kidney nephron formation), suggesting these proteins act as transcriptional regulators coordinating diverse developmental programs.","confidence":"High","size":11,"edges":36,"triangles":50,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0031018","count":5},{"id":"GO:0035914","count":5},{"id":"GO:0021986","count":5},{"id":"GO:0090190","count":5}]},{"hash":"286565823174042033","title":"Embryonic and organ development","description":"This cluster's top GO terms center on development and differentiation across tissues\u2014pancreatic, placental, cartilage, endocrine, heart, lens, and left-right patterning. The repeated emphasis on morphogenesis and differentiation suggests a role in embryogenesis and organogenesis rather than a single pathway, so a label like Embryonic and organ development captures the shared theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3}]},{"hash":"2137699574254441031","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by terms tied to ribosome production and function: ribosome biogenesis, large subunit assembly, and translation, with related processes such as transcription linked to ribosomal gene expression. The strong representation of GO:0042254 (ribosome biogenesis), GO:0006412 (translation), and GO:0000027 (large subunit assembly) supports a cohesive ribosome/protein-synthesis theme. A few terms like retina development may be incidental or species-specific, but do not override the ribosome-centric signal.","confidence":"High","size":11,"edges":9,"triangles":2,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042273","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000027","count":2}]},{"hash":"619144164865413764","title":"Placenta, Lung, and Liver Development","description":"Based on the GO terms, the cluster shows a strong enrichment for development of placenta, lung, and liver, suggesting a shared theme of organ development. While there are some immune signaling and response terms present, the most coherent core signal is organogenesis across multiple tissues, justifying this label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0001889","count":1},{"id":"GO:0002686","count":1},{"id":"GO:0046061","count":1}]},{"hash":"1459918886256075746","title":"Heart and nervous system development","description":"This cluster shows enrichment for heart-related morphogenesis (outflow tract morphogenesis, AV node activity) and neural development signals (commissural neuron axon guidance, sympathetic ganglion development, multicellular organism development), suggesting a shared role in cardiovascular and nervous system development, with supporting transcriptional regulation terms.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0003151","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0071679","count":2}]},{"hash":"2241570064554532952","title":"Mitotic cell cycle regulation","description":"The terms cluster around mitosis and cell-cycle transitions: G1/S and G2/M transitions, spindle pole separation, chromosome condensation, and DNA-templated transcription, all pointing to control of entry into and progression through mitosis and the cell cycle. While a couple of terms are obsolete or less specific, the dominant theme is mitotic regulation and cell proliferation.","confidence":"High","size":11,"edges":5,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010696","count":7},{"id":"GO:0000320","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0000082","count":7},{"id":"GO:0033598","count":7}]},{"hash":"32950295431629393","title":"Ubiquitin-Dependent Proteolysis & Metal Stress Response","description":"The cluster is dominated by ubiquitin-related degradation processes (polyubiquitination, SCF-dependent proteasomal pathways, K11-linked ubiquitination) and includes multiple metal-stress responses (cadmium, methylmercury, arsenic), suggesting a cohesive role in protein turnover under metal-induced stress, with supporting links to cell cycle and circadian regulation.","confidence":"High","size":11,"edges":13,"triangles":1,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0071276","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0000209","count":5},{"id":"GO:0070979","count":4}]},{"hash":"467255259181544949","title":"Glycan and nucleotide-sugar biosynthesis","description":"Based on the GO terms, this cluster is strongly enriched for glycan and nucleotide-sugar biosynthesis (glycogen, O-antigen/LPS, UDP-N-acetylglucosamine, GDP-mannose) indicating roles in building cell-surface polysaccharides and related carbohydrate metabolism. While a few catabolic terms appear, the dominant signal is synthesis of sugar nucleotides and polysaccharide structures.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":4},{"id":"GO:0009243","count":3},{"id":"GO:0009103","count":3},{"id":"GO:0006148","count":3},{"id":"GO:0009590","count":3}]},{"hash":"2074203148561140343","title":"Innate Immune Response and Complement Activation","description":"The cluster is enriched for innate immune response and complement activation terms (innate immune response, complement activation, acute inflammatory response) and includes immunological synapse formation, indicating immune cell signaling. Additional lipid transport and extracellular matrix terms suggest accompanying tissue remodeling and lipid handling, but the dominant signal is innate immunity with complement involvement.","confidence":"Medium","size":11,"edges":16,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0001771","count":3},{"id":"GO:0010886","count":3},{"id":"GO:2000483","count":3}]},{"hash":"1540413326183388660","title":"mRNA Splicing and Processing Regulation","description":"The top GO terms point to coordinated regulation of mRNA splicing (both alternative and via the spliceosome), mRNA stability, and export, along with components involved in translation preinitiation, all reflecting general mRNA lifecycle control rather than a single pathway. This suggests a cluster of proteins dedicated to processing, processing regulation, and handling of mRNA in the nucleus-to-cytoplasm flow.","confidence":"High","size":11,"edges":33,"triangles":66,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0075525","count":7},{"id":"GO:0048025","count":7},{"id":"GO:0001825","count":7},{"id":"GO:0001731","count":7}]},{"hash":"1516515863027516499","title":"RNA splicing and miRNA regulation","description":"The top GO terms cluster around mRNA splicing via the spliceosome (including its regulation), mRNA stability and decay, and regulatory ncRNA/miRNA\u2013mediated gene silencing, indicating a coherent role in post-transcriptional gene regulation through splicing and RNA silencing pathways; a separate neural development term is present but does not dominate the signal.","confidence":"High","size":11,"edges":53,"triangles":148,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0048025","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7}]},{"hash":"1056843448978229908","title":"Developmental transcription regulators and morphogenesis","description":"This cluster centers on DNA-templated transcription and its regulation, suggesting transcription factors or co-regulators, and it also links to multiple morphogenesis processes (anterior commissure, endothelial, and glossopharyngeal nerve morphogenesis) as well as EMT in heart development. The combination points to proteins coordinating gene expression during development and participating in tissue morphogenesis, despite some obsolete terms present in the set.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0033689","count":3},{"id":"GO:0021960","count":3},{"id":"GO:0003198","count":3}]},{"hash":"1070363571334662634","title":"Neural development and patterning","description":"The top GO terms cluster around neural development and specification\u2014forebrain, subpallium, peripheral nervous system neuron development, glial differentiation, and neuronal proliferation\u2014suggesting proteins involved in neural tissue patterning and maturation. A few terms reference other organ development (bronchiole development, pancreatic A cell development), which may reflect broader developmental programs or annotation noise, but the central theme remains neurodevelopment.","confidence":"High","size":11,"edges":30,"triangles":43,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0021920","count":11},{"id":"GO:0003322","count":11},{"id":"GO:0021905","count":11},{"id":"GO:0060435","count":11},{"id":"GO:1902723","count":11}]},{"hash":"1277579488970888846","title":"Ubiquitin-Proteasome Regulation of Cell Cycle","description":"This cluster centers on ubiquitination and proteasomal degradation (SCF-dependent ubiquitinylation, K11-linked ubiquitination, and autoubiquitination) and links to cell-cycle control (G2/M transition and mitotic cell cycle), with neddylation as a key regulatory modification; together these terms suggest coordinated proteostasis and cell-cycle regulation.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":9},{"id":"GO:0070979","count":8},{"id":"GO:0000086","count":8},{"id":"GO:0070911","count":7},{"id":"GO:0016032","count":7}]},{"hash":"1298535081617467541","title":"Skeletal muscle development and actin cytoskeleton","description":"The dominant terms are actin filament bundle assembly and skeletal muscle fiber development, indicating a focus on muscle cytoskeleton organization. A calcium ion response term fits with muscle signaling, while other terms are more peripheral (gene regulation, endocytosis, chromatin-related processes), but the core theme points to muscle differentiation tied to actin dynamics.","confidence":"High","size":11,"edges":51,"triangles":133,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":8},{"id":"GO:0048741","count":7},{"id":"GO:0043486","count":7},{"id":"GO:0051592","count":7},{"id":"GO:0010628","count":7}]},{"hash":"894608074104693951","title":"RNAi and miRNA regulation in development","description":"Top GO terms emphasize RNA interference\u2013mediated immunity and miRNA processing, suggesting a core RNAi/miRNA\u2013driven gene-regulation function. The inclusion of transcription and translational initiation terms, plus developmental processes like shoot apical meristem maintenance and germ-line development, indicates the cluster centers on gene-expression control during development across species. Therefore, a label focusing on RNAi/miRNA regulation in development is appropriate.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0051214","count":1},{"id":"GO:0000335","count":1},{"id":"GO:0060145","count":1},{"id":"GO:0010492","count":1}]},{"hash":"548887995973172926","title":"Sperm capacitation, zona binding, and acrosome reaction","description":"Top GO terms are dominated by sperm-related functions\u2014capacitation, binding to the zona pellucida, and the acrosome reaction\u2014key steps in fertilization. A few other terms (sporulation, cytokine production, enkephalin processing, LDL receptor\u2013related processes) appear as noise and do not reshape the main theme. Thus, the cluster most plausibly reflects fertilization-related sperm processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":3},{"id":"GO:0030435","count":3},{"id":"GO:0016540","count":3},{"id":"GO:0007339","count":2},{"id":"GO:0042089","count":2}]},{"hash":"1048670386164121509","title":"Ribosome Biogenesis, Translation, and Cell Division","description":"The terms cluster around ribosome production and protein synthesis (cytoplasmic translation, tRNA modification, ribosome biogenesis, ribosomal subunit export) and concurrent cell cycle/division processes (cell cycle, cell division, septum assembly), suggesting a module linking ribosome assembly with cytokinesis.","confidence":"High","size":11,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1903833","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1266348606202967428","title":"Rho/Ras GTPase signaling and synaptic regulation","description":"The dominant GO terms point to regulation of Rho and Ras GTPase signaling, and positive regulation of GTPase activity, plus synaptic processes like vesicle endocytosis and long-term potentiation. This suggests a cluster of proteins involved in small GTPase\u2013mediated signaling with roles in synaptic function and vesicle trafficking, with some ancillary links to immune or apoptotic processes.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0048488","count":2},{"id":"GO:0045953","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0046580","count":2}]},{"hash":"261427634740757989","title":"Neural development: axon guidance and synapse assembly","description":"These proteins cluster around core neural development functions: axon extension and guidance, localization to paranode/juxtaparanode regions, and promotion of synapse assembly, with ECM-related collagen organization supporting axon growth. Some terms also reflect neuronal migration (tangential migration to the olfactory bulb) and ECM/vascular context, but the dominant signal is neural development and axon targeting.","confidence":"High","size":11,"edges":16,"triangles":10,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048846","count":8},{"id":"GO:0030199","count":6},{"id":"GO:0019800","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0016525","count":6}]},{"hash":"1911407792031389478","title":"Multi-tissue Developmental Morphogenesis","description":"These proteins show a strong emphasis on development and tissue morphogenesis across multiple tissues, including mesoderm, cartilage, hair follicles, palate, and placental lineages. While a few terms relate to general cellular processes (splicing, ribosome export), the dominant signal is developmental morphogenesis across diverse tissues, justifying a broad developmental label.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007498","count":5},{"id":"GO:0031069","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0000398","count":5}]},{"hash":"864423716645438290","title":"Cholesterol homeostasis and lipid metabolism","description":"GO terms point to cholesterol transport and storage, cholesterol homeostasis, and various lipid metabolic processes (lipoprotein remodeling, linoleic acid and ceramide biosynthesis, lipoxin B4 biosynthesis), plus skin barrier lipid formation; together these suggest a cluster of proteins involved in lipid metabolism and cholesterol regulation, including lipid transport, lipid biosynthesis, and lipid-derived signaling relevant to skin barrier function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001306","count":1},{"id":"GO:0043691","count":1},{"id":"GO:0044241","count":1},{"id":"GO:0010886","count":1},{"id":"GO:0042994","count":1}]},{"hash":"1128384123835861290","title":"Mammary gland development and ECM remodeling","description":"Top terms point to mammary gland biology, including development, lactose biosynthesis for milk, apoptotic regulation during involution, and extracellular matrix remodeling via ECM secretion, hyaluronan synthesis, and angiogenesis, suggesting a coherent cluster of milk-related development and ECM-associated processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060058","count":3},{"id":"GO:0007339","count":3},{"id":"GO:0030879","count":3},{"id":"GO:0048147","count":3},{"id":"GO:0006486","count":3}]},{"hash":"1823445063124596464","title":"Embryonic development and tissue morphogenesis","description":"These GO terms cluster around developmental processes: placenta and trophoblast differentiation, cartilage morphogenesis, endocrine system development, EMT during heart cushion formation, left-right patterning, and pancreatic cell development. A couple entries mention membrane targeting/insertion, but the dominant signal is embryonic tissue development and morphogenesis. Thus the cluster is best labeled Embryonic development and tissue morphogenesis.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001580","count":1},{"id":"GO:0006612","count":1},{"id":"GO:0051205","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060536","count":1}]},{"hash":"2055433607126492610","title":"Mitochondrial Energy Metabolism and Redox Regulation","description":"Predominant GO terms are tied to mitochondrial metabolism and redox processes, notably the tricarboxylic acid cycle, mitochondrial NADH dehydrogenation to ubiquinone, and protein glutathionylation. While there are also terms related to development and hormone regulation, the strongest and most frequent signals point to mitochondrial energy production and redox signaling, which justifies a label focused on metabolism rather than a purely developmental function.","confidence":"High","size":10,"edges":40,"triangles":86,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":7},{"id":"GO:0046653","count":5},{"id":"GO:2000179","count":4},{"id":"GO:0060992","count":4},{"id":"GO:0046886","count":4}]},{"hash":"402817697181955414","title":"Mitotic cell cycle control and ubiquitination","description":"The cluster\u2019s top terms cluster around mitosis and cell cycle progression (mitotic cell cycle, cell division, anaphase-promoting complex-dependent catabolic process) and ubiquitin-mediated regulation (K11-linked ubiquitination), along with transcriptional control (DNA-templated transcription). While there are outliers related to cadmium response and innate immunity, the dominant theme ties to cell-cycle control and protein turnover via ubiquitination and some epigenetic regulation signals.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0043547","count":3},{"id":"GO:2001162","count":2},{"id":"GO:0070979","count":2}]},{"hash":"1413853269518514247","title":"Organ development and energy metabolism","description":"This cluster features developmental terms across multiple organs (heart, liver, substantia nigra, erythrocyte maturation) alongside energy-related processes (NADPH regeneration, carnitine metabolism, long-chain fatty acid catabolism) and signaling/neuronal activity (neurotransmitter secretion, GPCR signaling). The mix suggests proteins involved in coordinating organ development with metabolic and signaling pathways, rather than a single narrow function, justifying a label that encompasses both development and metabolism.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0043249","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0006740","count":2},{"id":"GO:0007205","count":2}]},{"hash":"1774697716898608585","title":"Neural development and ER-Golgi trafficking","description":"The terms point to neural development (brain development, radial glial scaffold formation) and ongoing growth/proliferation (cell division, mitotic cycle, multicellular growth), alongside robust secretory pathway activity (COPII vesicle budding, ER\u2013Golgi and retrograde ER\u2013Golgi transport) and ribosome biogenesis, suggesting a cluster focused on neurodevelopment supported by protein synthesis and trafficking.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0008283","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0042254","count":4}]},{"hash":"292178092474738418","title":"Notch-Driven Organogenesis and Neural Development","description":"The top term is Notch signaling, with numerous organogenesis terms across heart, retina, bronchioles, nephron morphogenesis, and glial/astrocyte differentiation, indicating a cohesive module of Notch-regulated development across multiple tissues.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":10},{"id":"GO:0072282","count":10},{"id":"GO:0009410","count":10},{"id":"GO:0003062","count":10},{"id":"GO:0021781","count":10}]},{"hash":"1798604256455584163","title":"Developmental cell migration and Rho-actin signaling","description":"The proteins are linked to actin-based movement and morphogenesis, with GO terms for cell migration, lamellipodium assembly, and Rho GTPase signaling, plus development of heart, thymus, and uterus and anterior/posterior patterning. While immune signaling terms appear (B cell receptor signaling, LPS pathways), the dominant theme is developmental motility and cytoskeletal regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":2},{"id":"GO:0009952","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0031666","count":2}]},{"hash":"673371098170730076","title":"DNA replication and cell cycle regulation","description":"The top GO terms are dominated by DNA replication, mitotic checkpoint signaling, and cell division, which strongly suggest the cluster's function relates to genome duplication and progression through mitosis. Other terms indicate supporting processes such as mRNA export, oxidative stress response, and autophagy, but they appear secondary to the main theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006406","count":5},{"id":"GO:0034599","count":5},{"id":"GO:0051301","count":5},{"id":"GO:1903724","count":4}]},{"hash":"700373078644767834","title":"Pain sensing and inflammatory chemokine regulation","description":"The terms cluster around pain detection (chemical/mechanical stimuli, cold) and upregulation of inflammatory chemokines (CXCL1, CCL5, MIP-1\u03b1), with supporting calcium signaling, pointing to a nociception-inflammation module.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043488","count":3},{"id":"GO:0071642","count":2},{"id":"GO:2000340","count":2},{"id":"GO:0071651","count":2},{"id":"GO:0030103","count":2}]},{"hash":"487385825472098893","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019243","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0034414","count":2},{"id":"GO:0034247","count":2},{"id":"GO:0098789","count":2}]},{"hash":"1322021684485468185","title":"ER\u2013Golgi Vesicle Trafficking","description":"The GO terms point to ER\u2013Golgi and retrograde vesicle transport, general protein transport, and endocytosis, plus membrane/organelle assembly processes like melanosomes and apical junctions, indicating a coherent theme of intracellular vesicle trafficking and membrane organization.","confidence":"High","size":10,"edges":16,"triangles":4,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0006890","count":5},{"id":"GO:0051291","count":4},{"id":"GO:0006897","count":4},{"id":"GO:0015031","count":4}]},{"hash":"291686107151737836","title":"GPCR-cAMP Dopamine/Adrenergic Signaling","description":"Cluster terms cluster around activation of adenylate cyclase and GPCR-mediated signaling, including dopamine receptor signaling, adrenergic receptor signaling, and downstream cAMP pathways (with PLC involvement and related processes like phototransduction and blood pressure regulation). An outlier term for electron transport chain is present but does not change the core GPCR-cAMP theme. ","confidence":"High","size":10,"edges":13,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":7},{"id":"GO:0010579","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0043950","count":7}]},{"hash":"2048284652701470243","title":"Keratinization and epidermal differentiation","description":"Most terms point to skin-related biology: keratinization, skin barrier establishment, and keratinocyte activation, plus hair follicle morphogenesis. While there are also terms related to lens fiber development and neural/cytoskeletal processes, the dominant signal is epidermal differentiation and keratinization, supporting a label focused on skin/epidermal biology with hair follicle development as a related facet. Confidence: Medium.","confidence":"","size":10,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":9},{"id":"GO:0001867","count":8},{"id":"GO:0043000","count":8},{"id":"GO:0033693","count":8},{"id":"GO:0061436","count":8}]},{"hash":"1275350017288726897","title":"Developmental gene regulation and cell cycle control","description":"Because the proteins cluster around calcium-NFAT signaling, transcriptional and chromatin regulation, and mitotic control, with supporting developmental terms (mesoderm and Schwann cell development), suggesting a role in coordinating gene expression and cell cycle during development.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0033173","count":10},{"id":"GO:0005981","count":10},{"id":"GO:0035562","count":10},{"id":"GO:0035690","count":10},{"id":"GO:0005977","count":10}]},{"hash":"695350790332533001","title":"Neuronal development and synaptic connectivity","description":"The cluster\u2019s top GO terms cluster around neuronal development processes\u2014axon guidance and fasciculation, neuron migration, cortical/layer formation, amacrine differentiation, and neuron adhesion\u2014as well as calcium-dependent exocytosis and membrane targeting, which together point to neurons coordinating development and forming synaptic connections. One term about melanotic encapsulation is likely noise/unrelated, but the overall theme remains neuronal development and connectivity.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":1},{"id":"GO:0021819","count":1},{"id":"GO:0001764","count":1},{"id":"GO:0035011","count":1},{"id":"GO:0021722","count":1}]},{"hash":"2065818070058387163","title":"Receptor signaling and endocytosis","description":"This cluster centers on receptor-driven signaling (insulin receptor signaling, ephrin receptor signaling) and membrane trafficking processes (caveolin-mediated endocytosis; regulation of Golgi to plasma membrane transport), with additional, context-setting terms related to immune signaling (B cell affinity maturation; IL-7 response) and development (mammary gland branching). The core themes are signaling via receptors and associated endocytic/trafficking pathways, making the label a concise reflection of the shared functions across the proteins.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042997","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0071732","count":3},{"id":"GO:0002344","count":3},{"id":"GO:0060444","count":3}]},{"hash":"1487508165933496516","title":"Neuronal development and synapse assembly","description":"The top GO terms point to nervous system development, CNS development, and synaptic organization, including positive regulation of synapse assembly and clustering of voltage-gated sodium channels, which are key for neuronal maturation and excitability. Additional terms on cell adhesion and migration fit neural network wiring, supporting a cohesive theme of neural development and synaptic formation, despite some obsolete entries.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0045162","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0000187","count":2}]},{"hash":"1532766654944913863","title":"Multi-tissue development and differentiation","description":"The GO terms point to developmental processes across diverse tissues (blood/hemato lineages, mesoderm, dendritic/immune differentiation, epithelial development, tracheal branching, R7 photoreceptor fate), rather than a single pathway. This suggests a broad cluster centered on developmental specification across multiple tissues, hence the label. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071425","count":1},{"id":"GO:0060233","count":1},{"id":"GO:2000382","count":1},{"id":"GO:0043011","count":1},{"id":"GO:0097011","count":1}]},{"hash":"1771724922882584834","title":"Translation Initiation and Ubiquitin-Proteostasis","description":"This cluster is driven by GO terms for translation initiation (formation of the preinitiation complex and translation reinitiation) and ubiquitin-related regulation (polyubiquitination and K11-linked ubiquitination, plus ERAD), suggesting a shared theme of coordinating protein synthesis with ubiquitin-mediated proteostasis. Some terms touch broader areas like cadmium response and cell cycle, but the strongest signal ties initiation of translation to protein quality control pathways.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:2000011","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0000209","count":3}]},{"hash":"1660911569024090507","title":"Endocytic trafficking and membrane dynamics","description":"This cluster shows a membrane trafficking theme, with GO terms for endocytic recycling, endosome localization, exocytosis, and plasma membrane remodeling, plus actin remodeling and cell motility regulation, suggesting participation in vesicle capture, transport, and fusion at the plasma membrane.","confidence":"Medium","size":10,"edges":26,"triangles":32,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1990126","count":1},{"id":"GO:0097320","count":1},{"id":"GO:0045035","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0043154","count":1}]},{"hash":"737214822817992060","title":"Calcium-Responsive Gene Regulation and Cell Polarity","description":"The cluster centers on calcium signaling influencing gene expression and cellular architecture, with links to skeletal muscle development, cell polarity, and mitochondrial localization. Despite some obsolete terms, the non-obsolete GO terms suggest a cohesive theme where Ca2+-dependent signaling modulates transcription and cell shape/organization, possibly coordinating energy localization and trafficking pathways.","confidence":"Medium","size":10,"edges":10,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":2},{"id":"GO:0043486","count":2},{"id":"GO:0051592","count":2},{"id":"GO:0010628","count":2},{"id":"GO:0030100","count":2}]},{"hash":"1075198890427548622","title":"Neural development with axon growth and glutamatergic signaling","description":"Based on the GO terms, this cluster centers on nervous system development, including cerebral cortex and inner ear development, along with processes like axon extension and glutamatergic synaptic transmission, plus related signaling (tyrosine phosphorylation). While a couple of housekeeping terms appear, the dominant theme is neural development and excitatory synapse formation.","confidence":"High","size":10,"edges":10,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0060711","count":2},{"id":"GO:2000114","count":2},{"id":"GO:0045773","count":2}]},{"hash":"1463051207178149361","title":"Developmental Angiogenesis and Growth Signaling","description":"This cluster centers on angiogenesis and organismal development, with terms like angiogenesis, multicellular development, and neural tube closure, plus VEGF/PDGF receptor signaling and PI3K-related activity pointing to growth signaling that drives cell proliferation. The transcriptional aspect (DNA-templated transcription) ties in to coordinated developmental regulation, and wound response reflects tissue remodeling during development.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0038091","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0071333","count":7},{"id":"GO:0043552","count":7}]},{"hash":"1498445162492354677","title":"Organelle biogenesis and quality control","description":"The top GO terms lean toward organelle maintenance and maturation (mitochondrial inner membrane insertion, Complex III assembly, endosomal microautophagy, intralumenal vesicle formation) and protein quality control (protein unfolding, rRNA decay quality checks). While there are also cell cycle signals, the common thread appears to be processes that build, assemble, and monitor organelles and proteins, i.e., organelle biogenesis coupled with quality control mechanisms. ","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:1903724","count":3},{"id":"GO:0032979","count":3},{"id":"GO:0070651","count":3},{"id":"GO:0061738","count":3}]},{"hash":"1699609445964642499","title":"Cytoskeletal remodeling and endosomal trafficking","description":"Proteins in this cluster are enriched for actin cytoskeleton dynamics (positive regulation of podosome assembly; negative regulation of stress fiber assembly) and endolysosomal processes (phagolysosome assembly; localization to early endosome), suggesting a theme of signaling-driven cytoskeletal remodeling linked to vesicle trafficking. Some hormonal and immune-response terms may reflect upstream signaling effects on these processes.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":2},{"id":"GO:0032496","count":2},{"id":"GO:1902966","count":1},{"id":"GO:0046665","count":1},{"id":"GO:0060396","count":1}]},{"hash":"2291487840117010814","title":"Unknown","description":"Top terms are highly diverse, spanning oocyte structure, chromatin modification, protein complex assembly, plant chlorophyll regulation, stress responses (unfolded protein, hydrogen peroxide, interferon), ubiquitination, metal ion response, and axonemal dynein assembly, with no clear shared theme; thus a meaningful functional label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030717","count":2},{"id":"GO:0016576","count":1},{"id":"GO:0051291","count":1},{"id":"GO:1902325","count":1},{"id":"GO:0006986","count":1}]},{"hash":"1643586839928573313","title":"Organismal growth and actin dynamics","description":"The top GO terms point to growth and development at the organism level (multicellular organism growth, regulation of multicellular organism growth) and to actin cytoskeleton remodeling (lamellipodium assembly and positive regulation of lamellipodium assembly), with secondary hints of adipose development and energy homeostasis. This suggests a cluster of proteins involved in growth-related processes along with cytoskeletal dynamics that drive cell movement and tissue development, rather than a single specialized pathway. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0030032","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0010592","count":2},{"id":"GO:2000251","count":2}]},{"hash":"1509142116162814742","title":"Eye and neural development signaling","description":"Top GO terms point to vertebrate embryonic development of sensory organs and neural structures (optic cup morphogenesis, neural tube development, olfactory pit development, retinoic acid receptor signaling). While metabolic terms are present, the prominent developmental pattern suggests a cluster focused on eye and neural patterning during development. ","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0055129","count":9},{"id":"GO:0036293","count":9},{"id":"GO:0009258","count":9},{"id":"GO:0060166","count":9},{"id":"GO:0010133","count":9}]},{"hash":"753326989479097307","title":"Lipid biosynthesis and remodeling with mitochondrial energy","description":"The cluster is dominated by lipid-related GO terms (ether lipids, triglycerides, phosphatidylcholine and cardiolipin remodeling, PAF biosynthesis) and a mitochondrial energy production term, pointing to lipid metabolism tightly linked to mitochondrial function. While a couple terms touch epithelial development or T-cell signaling, the overarching theme is lipid biosynthesis/remodeling coupled with mitochondrial energetics. ","confidence":"High","size":9,"edges":17,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008611","count":5},{"id":"GO:0010143","count":5},{"id":"GO:0002071","count":5},{"id":"GO:2001246","count":5},{"id":"GO:0019432","count":5}]},{"hash":"1763993133282117893","title":"Embryonic tissue differentiation and hormone signaling","description":"The top GO terms point to differentiation and fate determination across multiple tissues (endoderm, otic vesicle, pneumocytes, erythrocytes, neurons) and to signaling responses (BMP, estrogen, thyroid hormone). This suggests proteins in the cluster coordinate developmental differentiation and endocrine signaling rather than a single tissue-specific function.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007493","count":8},{"id":"GO:0071599","count":8},{"id":"GO:1900474","count":8},{"id":"GO:0060510","count":8},{"id":"GO:0045648","count":8}]},{"hash":"772572264316667650","title":"Immune signaling and cell adhesion/ECM remodeling","description":"The top GO terms point to immune pathway regulation (notably TLR3 signaling and T cell polarity) alongside modulation of cell\u2013cell and cell\u2013matrix interactions (cadherin regulation, cell adhesion molecule production, ECM disassembly). There are also related processes linked to excretion, aging, and mitochondrial/lipid metabolism (cardiolipin metabolism, mitochondrial membrane potential), suggesting a coordinated role in immune response scaling and tissue interface remodeling rather than a single metabolic pathway. Overall, these proteins seem to participate in immune signaling while also tuning adhesion and ECM dynamics at cellular interfaces.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1900210","count":9},{"id":"GO:0052547","count":9},{"id":"GO:0034141","count":9},{"id":"GO:0010918","count":9},{"id":"GO:0007588","count":9}]},{"hash":"2153668496438957299","title":"Chromatin localization and nucleolar transcription regulation","description":"This cluster is dominated by chromatin-related processes (establishment of protein localization to chromatin; snoRNA localization) and nucleolar transcription activities (positive regulation of Pol I\u2013transcribed rRNA), pointing to a core theme of chromatin organization coupled with ribosome biogenesis. Some terms about signaling (VEGF, TORC1) and motility appear, but the strongest, most coherent signal centers on chromatin-associated localization and nucleolar transcription/regulation. ","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":2},{"id":"GO:0033622","count":2},{"id":"GO:0035924","count":2},{"id":"GO:1904263","count":1},{"id":"GO:0090240","count":1}]},{"hash":"934071064653464185","title":"Mitochondrial fission and autophagy machinery","description":"The top GO terms point to mitochondrial dynamics (fission), autophagy initiation at the phagophore assembly site, and related cytoskeletal/tubulin processes, with copper homeostasis often connected to mitochondrial function. This suggests a cohesive theme around mitochondrial dynamics and autophagy machinery.","confidence":"High","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006878","count":8},{"id":"GO:0043950","count":7},{"id":"GO:0000266","count":7},{"id":"GO:0009740","count":7},{"id":"GO:0060789","count":7}]},{"hash":"1736309330890808366","title":"Hippo signaling and proteostasis stress response","description":"Top GO terms indicate a module combining Hippo signaling with proteostasis and transcriptional regulation under stress (ubiquitin-proteasome degradation, ERAD/aggresome formation, ER stress\u2013associated apoptosis, and RNA Pol II\u2013mediated transcription). This suggests a cohesive theme where Hippo signaling interfaces with stress-induced transcriptional changes and protein quality control pathways.","confidence":"Medium","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035329","count":6},{"id":"GO:0043433","count":5},{"id":"GO:0032436","count":5},{"id":"GO:0071276","count":5},{"id":"GO:0070059","count":5}]},{"hash":"1718776239468312891","title":"Neural development and oligodendrocyte progenitor proliferation","description":"The top GO terms center on nervous system development and specifically oligodendrocyte progenitor proliferation, indicating a CNS development and glial-proliferation theme; other apoptosis-related terms are secondary signals rather than the main driver.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0008344","count":2},{"id":"GO:0060548","count":1},{"id":"GO:0046909","count":1},{"id":"GO:1902043","count":1}]},{"hash":"480494788197841094","title":"Notch-regulated embryonic heart and neural development","description":"Most of the top GO terms center on Notch signaling (GO:0007219) and its roles in development across multiple organs, including heart formation and regulation of cardiac function (cardiac atrium formation, regulation of heart rate by chemical signal), neural/glial differentiation (glial cell fate commitment, astrocyte differentiation, neural retina development), and related organogenesis (bronchiole development). This pattern suggests a coherent theme of Notch-driven embryonic development affecting heart, neural tissues, and associated lineages, rather than a single tissue-specific function. A xenobiotic response appears as a secondary, potentially stress-related process rather than the core theme. ","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":9},{"id":"GO:0072282","count":9},{"id":"GO:0009410","count":9},{"id":"GO:0003062","count":9},{"id":"GO:0021781","count":9}]},{"hash":"1455552223212780987","title":"Mitochondrial energy metabolism and insulin response","description":"The cluster shows strong representation of mitochondrial-related processes (membrane fission, ATP transmembrane transport), energy regulation (adaptive thermogenesis, response to fatty acids), and insulin signaling (cellular/insulin stimulus, response to glucose). These together point to a coherent theme of mitochondrial dynamics controlling energy use and insulin responsiveness; a few terms like female pregnancy are broader metabolic contexts and may reflect systemic energy state. Overall, the proteins appear tied to mitochondrial energy production, lipid response, and insulin-related pathways.","confidence":"High","size":9,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007565","count":6},{"id":"GO:0061179","count":5},{"id":"GO:0090149","count":5},{"id":"GO:0032869","count":5},{"id":"GO:0000303","count":5}]},{"hash":"2188130839896857941","title":"Vesicle trafficking and exocytosis regulation","description":"This cluster centers on GO terms for ER-to-Golgi vesicle transport, endosome-to-lysosome transport, and exocytosis, plus regulation of podosome assembly. The recurrent theme is regulated vesicle movement and secretion rather than disparate cell-type\u2013specific functions, making \"vesicle trafficking and exocytosis regulation\" a concise, representative label.","confidence":"High","size":9,"edges":17,"triangles":17,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0033028","count":3},{"id":"GO:0060999","count":3},{"id":"GO:1902824","count":3},{"id":"GO:0097284","count":3},{"id":"GO:0071803","count":3}]},{"hash":"274522941495465981","title":"GPCR-cAMP Signaling in Blood Pressure Regulation","description":"The dominant terms center on GPCR signaling that activates adenylate cyclase and modulates cAMP, together with terms related to blood pressure regulation and kidney function (renin-angiotensin\u2013related processes and glomerular filtration). There are a few outlier terms (electronic transport chain, immune differentiation) that are less cohesive with the core theme, but the GPCR-cAMP\u2013driven cardiovascular/kidney regulation provides a coherent core.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":8},{"id":"GO:0045777","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0007190","count":7},{"id":"GO:0043950","count":5}]},{"hash":"201088763745573820","title":"Nuclear transcription and chromatin remodeling","description":"The cluster largely centers on transcriptional regulation and chromatin-level control, with terms like DNA-templated transcription, mRNA export, SAGA complex localization to transcription regulatory regions, and histone deubiquitination. Additional terms on DNA repair align with chromatin dynamics in the nucleus. A few terms (proline transport, vulval development, filamentous growth) are outliers and do not define the core function. ","confidence":"Medium","size":9,"edges":10,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":2},{"id":"GO:0043248","count":1},{"id":"GO:0040025","count":1},{"id":"GO:0035753","count":1},{"id":"GO:0016578","count":1}]},{"hash":"1152404805466773377","title":"Unknown","description":"The top GO terms cover a wide range of unrelated processes, including anthocyanin biosynthesis (plant pigment), several bacterial biosynthetic pathways (peptidoglycan and lipoteichoic acid, antibiotics), and unrelated developmental/neuronal terms (pituitary gland development, paranode axon localization) plus cell cycle. This lack of a coherent, single functional theme makes it unclear how these proteins are functionally related, so a concise, unified label is not warranted.","confidence":"","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0002175","count":3},{"id":"GO:0007049","count":3}]},{"hash":"150644375685639604","title":"Cytochrome P450 Xenobiotic Metabolism","description":"The cluster is dominated by GO terms pointing to P450-driven detoxification and metabolism, including epoxygenase P450 pathway, xenobiotic catabolic process, alkaloid catabolic process, and fatty acid omega-oxidation, suggesting a functional group of cytochrome P450\u2013mediated xenobiotic and lipid metabolism, with some development-related terms likely reflecting tissue-specific expression contexts.","confidence":"High","size":9,"edges":8,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019373","count":5},{"id":"GO:0042738","count":4},{"id":"GO:0009822","count":4},{"id":"GO:0030879","count":4},{"id":"GO:0019341","count":4}]},{"hash":"299648399726049559","title":"Chromatin remodeling and transcription regulation","description":"This cluster centers on chromatin state control and transcription initiation/regulation, with terms pointing to chromatin remodeling, heterochromatin boundary formation, and RNA polymerase II promoter\u2013related initiation and start-site regulation. Although several terms are obsolete, the remaining signals suggest a shared function in regulating chromatin structure and transcription, rather than a single enzymatic activity or pathway.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071599","count":1},{"id":"GO:0051569","count":1},{"id":"GO:0031454","count":1},{"id":"GO:0006367","count":1},{"id":"GO:0000414","count":1}]},{"hash":"1632284374386967807","title":"Mesoderm Formation and Stem Cell Differentiation","description":"This cluster centers on developmental programs: mesoderm formation and positive regulation of stem cell differentiation are prominent terms, alongside signals that promote cell proliferation and DNA replication (e.g., VEGF/PDGF signaling). The presence of muscle activity response and nitric oxide signaling further supports a mesoderm-derived tissue development theme (muscle and vasculature) with proliferative regulation, rather than a single isolated function.","confidence":"High","size":9,"edges":20,"triangles":16,"max_degree":6,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":9},{"id":"GO:0014850","count":9},{"id":"GO:0006351","count":9},{"id":"GO:2000738","count":9},{"id":"GO:0001707","count":9}]},{"hash":"1088071475999623981","title":"Endosomal trafficking and viral egress","description":"The terms are dominated by endosomal transport and virus-related processes (late endosome to vacuole transport via MVB sorting, viral capsid secondary envelopment, viral release from host cell) with supporting protein transport and membrane-trafficking terms. Some non-related terms appear, so the theme is present but not exclusively cohesive.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900363","count":2},{"id":"GO:0009838","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0046745","count":1},{"id":"GO:0032511","count":1}]},{"hash":"1747482690859741573","title":"Ubiquitin-Dependent ER-Golgi Trafficking and Membrane Repair","description":"This cluster is enriched for GO terms centered on ubiquitination (protein ubiquitination, ubiquitin-dependent ERAD) and vesicle trafficking between the ER and Golgi (COPII-coated vesicle budding, retrograde Golgi-to-ER transport). Additional terms on membrane repair and podosome-related processes suggest vesicle fusion and membrane remodeling activities across cell types. Together, these terms point to a shared role in ubiquitin-regulated secretory/quality-control pathways and membrane maintenance.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0001782","count":3},{"id":"GO:0001778","count":3},{"id":"GO:0030433","count":3}]},{"hash":"660398089087439474","title":"Collagen-ECM Signaling and Basement Membrane Formation","description":"This cluster centers on extracellular matrix components and interactions, including collagen turnover, integrin production, and basement membrane-related development. GO terms point to collagen catabolic process, collagen-activated signaling, integrin biosynthetic process, and glomerular basement membrane development, indicating a cohesive ECM remodeling/adhesion theme relevant to tissue structure and kidney-associated basement membranes.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031322","count":2},{"id":"GO:0038063","count":1},{"id":"GO:0001957","count":1},{"id":"GO:0045112","count":1},{"id":"GO:0060355","count":1}]},{"hash":"1661976382213052335","title":"Neuronal Development and Axon Guidance","description":"The top GO terms cluster around neural development: neural tube closure, motor neuron axon guidance, and cell-matrix adhesion, supported by growth factor signaling pathways (PI3K/AKT, PDGF receptor, growth hormone signaling). Also includes regulation of glial cell survival, DNA repair, and proteasomal protein turnover, which can be active during neural differentiation and maturation. The common thread is neuronal development and axon pathfinding with supportive signaling and adhesion.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034351","count":5},{"id":"GO:0051897","count":5},{"id":"GO:0010641","count":5},{"id":"GO:0001843","count":5},{"id":"GO:0007160","count":5}]},{"hash":"619663914510474582","title":"Actin-driven cytoskeletal remodeling","description":"Top GO terms cluster around actin cytoskeleton dynamics (actin cortical patch localization, microspike assembly, lamellipodium morphogenesis) and vesicle-related processes (synaptic vesicle uncoating), suggesting a shared role in cytoskeletal remodeling and membrane trafficking. Some terms relate to signaling and developmental processes, but the predominant signal points to actin- and motility-related functions.","confidence":"Medium","size":9,"edges":10,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071732","count":8},{"id":"GO:0061847","count":8},{"id":"GO:0030702","count":8},{"id":"GO:0051666","count":8},{"id":"GO:0030035","count":8}]},{"hash":"778893838983549199","title":"Neuronal development and cytoskeletal signaling","description":"Top GO terms point to regulation of GTPase activity and cytoskeletal dynamics (dendritic spine morphogenesis, podosome assembly, cell spreading) together with neuronal plasticity (synaptic regulation). Developmental and immune-related terms (heart and cranial skeletal development, T cell receptor signaling) suggest these proteins participate in signaling pathways that modulate the cytoskeleton across neural, developmental, and immune contexts. The cohesive theme is cytoskeletal regulation during development and synaptic function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0048170","count":3},{"id":"GO:0038083","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1848844554157249972","title":"Developmental regulation and chromatin modification","description":"The cluster\u2019s GO terms prominently cover developmental processes (skeletal system development, neural tube closure, multicellular organism development) along with cell cycle and transcription-related activities, plus chromatin-related modifications (histone methylation and ubiquitination). This combination points to proteins involved in regulating development via transcriptional and epigenetic mechanisms, rather than a single pathway; hence the label emphasizing development with chromatin regulation. The cadmium response term adds stress responsiveness but does not redefine the main theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0001843","count":3}]},{"hash":"1189300894529286463","title":"Splicing and mRNA processing","description":"These proteins cluster around spliceosome-mediated mRNA splicing (including alternative splicing), polyadenylation and other RNA processing steps, as well as regulatory aspects of mRNA stability and translation initiation, indicating a core RNA processing/splicing module.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0010610","count":7},{"id":"GO:0045292","count":7},{"id":"GO:0075525","count":6}]},{"hash":"669604722285018784","title":"Nuclear ubiquitin-regulated transcription and chromatin modification","description":"The terms cluster around ubiquitin-related processes (ubiquitin-dependent protein catabolic process; free ubiquitin chain depolymerization; regulation of ubiquitin ligase activity; deubiquitination) together with transcription and RNA processing (DNA-templated transcription, regulation of transcription, mRNA processing, histone deubiquitination). This suggests a nuclear role where ubiquitination status modulates transcription and chromatin state; a related necroptosis term is likely ancillary. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0010995","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0006355","count":1}]},{"hash":"316059076996124219","title":"Developmental gene regulation and stress responses","description":"The top GO terms center on transcription, mRNA processing, and DNA-related processes aligned with development (neural tube closure, multicellular development) while also highlighting cellular stress responses (cadmium, ER stress\u2013induced apoptosis, defense against bacteria). This points to a cluster broadly involved in developmental gene expression with concurrent stress response pathways, rather than a single tight module.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0000278","count":2}]},{"hash":"2250117898903653411","title":"Synaptic development and cytoskeletal dynamics","description":"The GO terms point to synapse formation and neuron projection growth, with multiple entries for actin-dependent motility and excitatory postsynaptic potential regulation. While a couple of terms reference chromatin or insulin signaling, the dominant theme is synapse establishment and cytoskeletal remodeling in neurons.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030702","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0001771","count":2},{"id":"GO:0042997","count":2},{"id":"GO:0051282","count":2}]},{"hash":"51151792491027938","title":"Negative Regulation of Signaling Pathways","description":"This cluster is dominated by GO terms about inhibiting signaling pathways (BMP/TGF-\u03b2, TGF-\u03b2 receptor, NF-kappaB, SMAD-related processes) and includes a dephosphorylation mechanism and nuclear export regulation, pointing to a common theme of signaling attenuation and transcriptional control. Some terms reflect plant-specific processes (meristem identity, photosystem adjustments), but the overarching pattern is suppression or fine-tuning of signaling cascades.","confidence":"Medium","size":9,"edges":8,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010991","count":5},{"id":"GO:0035970","count":5},{"id":"GO:0061191","count":5},{"id":"GO:0080005","count":5},{"id":"GO:0010074","count":5}]},{"hash":"598033010420425409","title":"Negative regulation of inflammatory immune signaling","description":"This cluster centers on dampening of immune and inflammatory pathways, with GO terms pointing to negative regulation of IL-2 and IL-1\u03b2 production, TLR3 signaling, CD40 signaling, and mucosal immune responses, plus B-1 B cell homeostasis. The presence of K33- and K6-linked deubiquitination terms suggests regulatory post-translational control of signaling cascades. While a growth hormone response term appears, the dominant signal is suppression of inflammatory/immune signaling, indicating these proteins act as negative regulators of immune activation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060416","count":2},{"id":"GO:0032703","count":1},{"id":"GO:0002677","count":1},{"id":"GO:2000349","count":1},{"id":"GO:1990168","count":1}]},{"hash":"887347706291857453","title":"Stem Cell Differentiation and Mesoderm Development","description":"This cluster centers on developmental processes, with terms like mesoderm formation, positive regulation of stem cell differentiation, DNA-templated transcription, and regulation of the nuclear cell cycle/DNA replication, suggesting roles in differentiation and proliferation during development. Some outliers (response to nitric oxide, biofilm formation) may reflect broader signaling contexts or annotation noise, but the core theme is developmental control and cell-cycle regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":4},{"id":"GO:0014850","count":4},{"id":"GO:0006351","count":4},{"id":"GO:2000738","count":4},{"id":"GO:0001707","count":4}]},{"hash":"1458613509569212595","title":"Collagen Biosynthesis and ECM Organization","description":"The GO terms are dominated by collagen-related processes (collagen fibril organization, collagen biosynthetic process) and ECM-related activities, with supporting terms like cuticle/molting collagen and glycosylation of ECM proteins. This points to a cohesive theme of extracellular matrix assembly and collagen production, making this an appropriate, specific label.","confidence":"High","size":9,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051918","count":1},{"id":"GO:0018996","count":1},{"id":"GO:0002605","count":1},{"id":"GO:0042535","count":1},{"id":"GO:0032331","count":1}]},{"hash":"792035274787246483","title":"Sensory Processing and Stimulus Response","description":"The proteins in this cluster are dominated by GO terms for sensory perception of sound and sensory processing, plus reflexive responses like startle and various chemical- or drug-induced responses (cocaine, insecticide) and regulation of drug response, pointing to a cohesive theme of detecting and reacting to external stimuli. A few terms related to acrosome reaction, amyloid-beta response, BMP signaling regulation, and ovulation cycle rhythm are more peripheral but do not override the core sensory-response pattern.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0030514","count":3},{"id":"GO:0050893","count":3},{"id":"GO:0007340","count":3},{"id":"GO:0042220","count":3}]},{"hash":"1477620614174267369","title":"Unknown","description":"The GO terms are highly diverse and do not reveal a single cohesive function or pathway (apoptosis in glial/nurse cells, hypoxia, immune signaling, xenobiotic responses, autophagy regulation, platelet formation). The lack of edges among the proteins further suggests there is no shared molecular module, so Unknown is the best label.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034349","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0001666","count":1},{"id":"GO:0016241","count":1},{"id":"GO:0034612","count":1}]},{"hash":"2111214414159735234","title":"Actin Cytoskeleton Remodeling and Cell Polarity","description":"The top GO terms are centered on actin filament depolymerization and actin cytoskeleton organization, with related processes like cell morphogenesis and establishment of cell polarity. Additional terms such as Ras signaling and axon guidance fit with cytoskeletal remodeling during morphological changes and cell polarity establishment. Together they point to a functional cluster of proteins regulating actin dynamics and polarity during morphogenesis.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030836","count":1},{"id":"GO:0045761","count":1},{"id":"GO:0030042","count":1},{"id":"GO:0030036","count":1},{"id":"GO:0031138","count":1}]},{"hash":"1863680743893656366","title":"Embryonic Development and Morphogenesis","description":"The top GO terms are dominated by tissue morphogenesis and developmental processes across multiple lineages (mesoderm, hair follicles, cartilage, craniofacial structures, trophoblast, pancreatic cells), indicating a coherent theme of embryonic development and morphogenesis. A couple of general cellular processes appear as background signals, but they do not override the main developmental pattern.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007498","count":9},{"id":"GO:0031069","count":9},{"id":"GO:0060021","count":9},{"id":"GO:0000055","count":9},{"id":"GO:0000398","count":9}]},{"hash":"110816207800370221","title":"RNA and protein methyltransferases","description":"This cluster is dominated by GO terms for methylation of RNA species (mRNA capping, guanine-N7 methylation, rRNA and tRNA methylation) and for protein methylation (peptidyl-lysine methylation/monomethylation/dimethylation), indicating a cohesive group of methyltransferase enzymes acting on both RNA and proteins. Some auxiliary terms (antibiotic biosynthetic process, nodulation, tellurium ion response) may reflect broader bacterial methyltransferase roles or stress responses but do not override the central theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":3},{"id":"GO:0018027","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0018364","count":2},{"id":"GO:0046690","count":2}]},{"hash":"1333527439231646123","title":"Mitochondrial translation and tRNA charging","description":"This cluster is centered on translation-related processes, with terms for mitochondrial glycyl-tRNA aminoacylation, cytoplasmic translation, and regulation of translational fidelity, plus mitochondrial DNA metabolism and selenocysteine-related translation. The common thread is protein synthesis machinery, especially in mitochondria, making a translation-focused label appropriate.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1903833","count":1},{"id":"GO:0071897","count":1},{"id":"GO:0015970","count":1},{"id":"GO:0016260","count":1},{"id":"GO:0070150","count":1}]},{"hash":"2298199129976620820","title":"Developmental transcription regulators","description":"The cluster shows enrichment for terms related to regulation of transcription during development across multiple tissues (pituitary gland, forebrain, uterine epithelium, cardiac development, neuron differentiation). While there are some metabolism-related terms that could introduce noise, the prominent theme is transcriptional control linked to developmental processes, suggesting these proteins may function as regulators of gene expression during differentiation. ","confidence":"Medium","size":8,"edges":8,"triangles":5,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042853","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0021983","count":3},{"id":"GO:2000691","count":3}]},{"hash":"2131413130365932713","title":"Broad-Substrate Transmembrane Transporters","description":"The GO terms indicate transport of a variety of substrates across membranes (sugars like galactose and arabinose, nitrite/nitrate, vitamins, sodium ions, xenobiotics, and more) plus vesicular neurotransmitter loading, pointing to a cluster of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":8,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":6},{"id":"GO:0015757","count":6},{"id":"GO:0098700","count":6},{"id":"GO:0015707","count":6},{"id":"GO:0006855","count":6}]},{"hash":"1888830643562064664","title":"Ribosome biogenesis and translation initiation","description":"The dominant GO terms point to ribosome-related processes: translation, formation of the translation preinitiation complex, maturation of SSU-rRNA, and ribosome biogenesis, indicating proteins involved in ribosome assembly and initiating protein synthesis. Other terms like mitotic processes or DNA repair are present but less central to the cluster\u2019s main function.","confidence":"High","size":8,"edges":14,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1680587572387483524","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031204","count":7},{"id":"GO:0006626","count":7},{"id":"GO:0001707","count":7},{"id":"GO:0046825","count":7},{"id":"GO:0006986","count":7}]},{"hash":"742351625766258902","title":"Biosynthesis and transcription regulation cluster","description":"The top GO terms show a mix of biosynthetic processes (poly-hydroxybutyrate, O antigen, wax biosynthesis, long-chain fatty-acyl-CoA, ubiquinone biosynthesis) and transcription-related activity (DNA-templated transcription, nitrogen catabolite repression of transcription). This suggests a cluster enriched for metabolic biosynthesis alongside transcription regulation, rather than a single unified pathway. An occasional unrelated term may reflect annotation noise. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0009243","count":3},{"id":"GO:0010025","count":3},{"id":"GO:0006351","count":3}]},{"hash":"964967525622207980","title":"Exosome secretion and vesicle trafficking in epithelia","description":"The cluster\u2019s top GO terms cluster around exosomal secretion, multivesicular body sorting, and vesicle transport, including transcytosis and protein movement to vacuoles. Tight junction assembly and actin cytoskeleton dynamics also point to epithelial polarity and vesicle trafficking processes. Together these suggest a function focused on vesicle-mediated secretion and transport, particularly exosome-related pathways in epithelial contexts. ","confidence":"Medium","size":8,"edges":14,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1904669","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0045752","count":2},{"id":"GO:1990182","count":2},{"id":"GO:1903543","count":2}]},{"hash":"36799534731697304","title":"mRNA splicing and translation initiation","description":"These proteins hover around RNA processing and control of translation: spliceosome-mediated, regulated and alternative splicing; mRNA export from the nucleus; mRNA stabilization, especially under stress; and steps toward forming the translation preinitiation complex, plus translation initiation (including viral termination\u2013reinitiation). This convergence suggests a cohesive role in coordinating mRNA maturation with the start of translation, despite a few outlier terms such as blastocyst formation. ","confidence":"High","size":8,"edges":22,"triangles":29,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":8},{"id":"GO:0075525","count":7},{"id":"GO:0048025","count":7},{"id":"GO:0001825","count":7},{"id":"GO:0001731","count":7}]},{"hash":"13986868679726230","title":"Developmental signaling and cytoskeletal remodeling","description":"The terms cluster around developmental signaling (Smoothened pathway, axon guidance, ossification, spermatid development) and cytoskeletal dynamics (filopodium and stress fiber assembly) with related cell migration and tissue morphogenesis, suggesting a cohesive developmental/morphogenetic theme.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032729","count":6},{"id":"GO:0048873","count":6},{"id":"GO:0007411","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0007286","count":5}]},{"hash":"621454576808572398","title":"Endosome-Golgi/Melanosome Vesicle Trafficking","description":"The top GO terms cluster around intracellular vesicle transport: endosome to Golgi, Golgi to endosome, multivesicular body sorting, endosome-to-melanosome transport, and regulation of synaptic vesicle endocytosis, with autophagy-related regulation linking to vesicle dynamics. Some terms about development appear as noise, but the dominant signal is vesicle trafficking among endosomal and Golgi compartments, plus autophagy modulation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0071985","count":2},{"id":"GO:0035646","count":2}]},{"hash":"2226257541378847477","title":"Cross-tissue development and differentiation","description":"The GO terms point to tissue-specific development across diverse organs (bone/osteoblasts, pancreatic A cells, bronchioles, forebrain/midbrain boundary, spinal cord), plus related transcriptional and chromatin regulation and some differentiation control. There isn\u2019t a single dominant pathway, but a broad theme of developmental and differentiation processes across multiple tissues, which justifies a cross-tissue development label rather than a tissue-specific function. ","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002076","count":3},{"id":"GO:0030702","count":2},{"id":"GO:0021920","count":2},{"id":"GO:0003322","count":2},{"id":"GO:0021913","count":2}]},{"hash":"2287333642593993807","title":"ECM assembly and connective tissue development","description":"The proteins cluster around extracellular matrix organization, basement membranes, collagen fibrils, integrin synthesis, and tissue differentiation (tendon, glomerular basement membrane, bone ossification), indicating a cohesive ECM/connective tissue development theme; a minor immune-related term is present but not central.","confidence":"High","size":8,"edges":6,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0001867","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0045112","count":2}]},{"hash":"1483303839649218358","title":"Nuclear RNA Localization and Telomere Maintenance","description":"The top GO terms center on localization of RNA components to Cajal bodies (scaRNA localization, telomerase RNA localization to Cajal bodies) and establishment of protein localization to telomeres, plus related nuclear processes like pore complex assembly and cell cycle. This points to a thematic cluster of nuclear RNA processing/trafficking and telomere maintenance. Some terms appear obsolete or unrelated (sperm binding to zona pellucida, cocaine response), likely representing annotation noise rather than core connections. Overall, the set seems best described by nuclear RNA localization and telomere biology.","confidence":"Medium","size":8,"edges":25,"triangles":41,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051086","count":8},{"id":"GO:0007339","count":8},{"id":"GO:0090666","count":8},{"id":"GO:1904874","count":8},{"id":"GO:1901998","count":8}]},{"hash":"373943579361093905","title":"Mitochondrial energy metabolism and insulin signaling","description":"The cluster centers on mitochondrial processes\u2014fission, ATP transport, and membrane potential\u2014and links them to insulin/glucose signaling, thermogenesis, fatty acid response, and oxidative stress, suggesting a cohesive set of proteins involved in mitochondrial energy homeostasis.","confidence":"High","size":8,"edges":17,"triangles":14,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":3},{"id":"GO:0090149","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0000303","count":3},{"id":"GO:1990845","count":3}]},{"hash":"168601189531381544","title":"Unknown","description":"The top terms show a scattered mix (toxic/xenobiotic response, proteasome-related processes, development and signaling terms, plus several obsolete annotations) with no clear, cohesive function linking the proteins. The lack of edges and the presence of unrelated terms (e.g., ossification, neural proliferation) suggest there isn\u2019t a single interpretable theme for this cluster. ","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0050790","count":1},{"id":"GO:2000179","count":1},{"id":"GO:1903955","count":1}]},{"hash":"1572751648731672253","title":"Diverse Transmembrane Solute Transporters","description":"The top GO terms cluster around transmembrane transport of a wide range of substrates (ions like sodium and potassium, nitrate, sugars such as galactose and arabinose, vitamins, sialic acid, xenobiotics, and even neurotransmitter loading into synaptic vesicles). Although there are no reported interactions, the common theme is membrane transport for diverse solutes, justifying a label of diverse transmembrane solute transporters.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0071805","count":3}]},{"hash":"1742301262811840259","title":"Unknown","description":"The GO terms span secretory pathway (Golgi vesicle budding, exosomal secretion) but also include very diverse functions (dendrite development, keratinization, muscle satellite cell migration, xenobiotic response, immune cell apoptosis, MAPK transport, mitochondrial organization). This broad and mixed set lacks a single cohesive function or pathway linking all proteins, so a specific label isn\u2019t supported.","confidence":"","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048194","count":8},{"id":"GO:1902766","count":8},{"id":"GO:0035690","count":8},{"id":"GO:0051291","count":8},{"id":"GO:0016358","count":8}]},{"hash":"1670863860365912992","title":"Neural signaling and vesicle exocytosis","description":"Most top GO terms relate to neuronal function: exploration behavior, sensory perception of sound, and negative regulation of excitatory postsynaptic potential, together with vesicle docking in exocytosis, pointing to synaptic transmission and neural signaling. Other terms reference transcription regulation and cell polarity, but the strongest signal comes from neural communication and vesicle trafficking, supporting this label.","confidence":"Medium","size":8,"edges":8,"triangles":1,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035640","count":4},{"id":"GO:0090394","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0006904","count":3}]},{"hash":"1169466537827759642","title":"Plant amino acid and chlorophyll biosynthesis","description":"This cluster centers on biosynthetic and catabolic pathways for amino acids (proline, arginine via ornithine, beta-alanine) and chlorophyll, with supporting redox homeostasis and some transcriptional regulation. GABA and putrescine catabolism further point to plant-specific metabolism and stress-related remodeling. The antibiotic biosynthesis term seems out of place and likely annotation noise, but does not define the group. Overall, the theme fits plant metabolic biosynthesis, warranting the label, with Medium confidence.","confidence":"Medium","size":8,"edges":11,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0055129","count":1},{"id":"GO:0015995","count":1}]},{"hash":"2187133979107356091","title":"Cerebral cortex development and neuron migration","description":"GO terms indicate a neurodevelopmental module focused on cerebral cortex formation, including synapse assembly, neuron migration and layer formation, blood-brain barrier establishment, and brain organ identity maintenance, with some CNS signaling terms such as corticosterone regulation and cocaine response.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:2001223","count":3},{"id":"GO:0032792","count":2},{"id":"GO:1901223","count":2},{"id":"GO:0042220","count":2}]},{"hash":"1114047935654748159","title":"Cytokine and Hormone Signaling","description":"The cluster\u2019s top GO terms cluster around signaling cascades triggered by cytokines and hormones: IL-27 signaling, Th2 cytokine production, STAT tyrosine phosphorylation, prolactin signaling, and follicle-stimulating hormone response. While there are outliers related to neural plasticity and muscle assembly, the dominant pattern is immune and endocrine signaling, justifying this label as representative of the cluster\u2019s core function.","confidence":"Medium","size":8,"edges":20,"triangles":22,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042517","count":6},{"id":"GO:0035745","count":6},{"id":"GO:0070106","count":6},{"id":"GO:0048671","count":5},{"id":"GO:0045163","count":5}]},{"hash":"1020239633075232146","title":"Neural development and cadherin-mediated adhesion","description":"The top GO terms cluster around neural development: brain development, inner ear development, neuronal stem cell maintenance, and locomotory behavior, with cadherin-mediated cell-cell adhesion suggesting a role in neural tissue morphogenesis and connectivity. While some terms are broader (e.g., transcriptional regulation), the core signal points to neural development with adhesion mechanisms.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0007626","count":4},{"id":"GO:0048839","count":4},{"id":"GO:0072137","count":3},{"id":"GO:0001955","count":3}]},{"hash":"1357726395123228411","title":"Developmental signaling and cell adhesion","description":"This cluster centers on signaling pathways (Rho and PI-mediated) that regulate cytoskeletal dynamics, cell movement, and cell\u2013cell adhesion, with GO terms tied to brain and endodermal development, suggesting a cohesive role in developmental signaling and adhesion. A few terms (chlorophyll biosynthesis, proteasome assembly) appear as outliers or annotation noise.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0048015","count":2},{"id":"GO:0043248","count":1},{"id":"GO:0035987","count":1}]},{"hash":"2171169888944043568","title":"Cardiac Development and Contractile Regulation","description":"The top GO terms are dominated by heart-related processes (heart development, cardiac muscle contraction) and regulation of contraction, indicating a cluster focused on cardiac development and heart muscle function. While there are additional terms (visual perception, thyroid development) that are less central, the strongest signals point to cardiac development and regulation of cardiac contractility.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0030878","count":2},{"id":"GO:0002031","count":2}]},{"hash":"1014419237978735464","title":"Growth-related ribosome biogenesis and vesicle trafficking","description":"The top GO terms cluster around ribosome biogenesis, cell division/cell cycle, and vesicle trafficking (endocytosis and Golgi-to-ER transport), with supporting growth-related signaling. This points to a group of proteins involved in growth-driven protein synthesis and intracellular transport, justifying a label focused on growth, ribosome biogenesis, and vesicle trafficking.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0060416","count":2},{"id":"GO:0006897","count":2}]},{"hash":"2082206768339216043","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000184","count":4},{"id":"GO:0034476","count":3},{"id":"GO:0006268","count":3},{"id":"GO:0070870","count":3},{"id":"GO:0000390","count":3}]},{"hash":"999989292484441533","title":"ER-Golgi trafficking and cell growth","description":"Dominant terms cluster around ER-to-Golgi transport and COPII vesicle budding, pointing to a primary role in the secretory pathway. The presence of cell division and mitotic growth terms suggests a possible link between vesicle trafficking and cell cycle or organismal growth, indicating the proteins may participate in both secretion and proliferation-related processes.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001649","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0090114","count":4},{"id":"GO:0051301","count":4}]},{"hash":"1580879523103935158","title":"Histone acetylation and imaginal disc development","description":"The top GO terms cluster around histone acetylation (H3/H4 acetylation) and regulation of transcription, with development-related terms such as imaginal disc fusion and sensory organ precursor fate determination. This points to chromatin modification guiding developmental gene expression, particularly in insect imaginal discs, despite some terms being obsolete. Thus the label captures the shared function of chromatin modification linked to development.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043966","count":5},{"id":"GO:0045652","count":5},{"id":"GO:0043981","count":5},{"id":"GO:0043983","count":5},{"id":"GO:0016360","count":5}]},{"hash":"2165745585808272580","title":"Cortical Neuronal Signaling and Development","description":"The top GO terms cluster around neuronal communication and cortical development: GABA signaling, regulation of vesicle fusion, synaptic plasticity modulation, and protein localization to cortical microtubules, all pointing to neuronal signaling and cortex formation. While there are a few broader terms (cell cycle, angiogenesis, insulin secretion) present, the dominant theme appears to be neuronal signaling and cortical development.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0031340","count":8},{"id":"GO:0033135","count":8},{"id":"GO:0051282","count":8},{"id":"GO:0007214","count":8},{"id":"GO:0000086","count":8}]},{"hash":"783804562565450665","title":"Embryonic and organ development","description":"Top GO terms point to development across multiple tissues\u2014inner ear, brain, forebrain, limb morphogenesis, gonads, uterus, and visual perception\u2014indicating a broad developmental program rather than a single tissue-specific function. While there are a few outliers (transcriptional regulation, complement activation), the dominant theme is embryonic and organ development across systems.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":4},{"id":"GO:0021846","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0007601","count":3}]},{"hash":"1360124301129065626","title":"Immune signaling and vascular development regulation","description":"This cluster centers on signaling pathways linked to immune cell differentiation and activation (insulin receptor signaling, B cell maturation, IL-7 response, NK T cell differentiation) alongside processes of cytoskeletal remodeling and migration (actin organization, cell migration) and vascular/heart development (vascular remodeling, heart development). The combined terms suggest a regulatory network that links immune signaling with cytoskeletal dynamics and vascular/heart development rather than a single, narrow function. ","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0008286","count":6},{"id":"GO:0002344","count":6},{"id":"GO:0098761","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0030036","count":6}]},{"hash":"2057313081028036527","title":"Embryonic development and morphogenesis","description":"Based on the GO terms, this cluster gathers processes related to embryonic development and tissue morphogenesis, including mesoderm development, left-right pattern formation, cartilage and hair follicle morphogenesis, and placental/trophoblast differentiation. The presence of intracellular signal transduction and actin filament organization terms supports a role in the signaling and cytoskeletal rearrangements that drive morphogenesis. Together, these terms point to a cohesive theme of developmental patterning and tissue formation rather than a single pathway or tissue-specific function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035556","count":5},{"id":"GO:0051017","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060707","count":5}]},{"hash":"1980066126035089990","title":"Diverse regulatory proteins in signaling and development","description":"The GO terms point to broad regulatory roles across signaling (calcineurin-NFAT cascade), metabolism (glycogen regulation), chromatin control, transcription termination, development (mesoderm, Schwann cells), and cell-cycle regulation (mitotic spindle attachment, chromosome condensation), plus xenobiotic response. There isn\u2019t a single cohesive pathway linking all terms, suggesting a cluster of diverse regulators rather than a tight functional module. ","confidence":"Low","size":8,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0033173","count":2},{"id":"GO:0005981","count":2},{"id":"GO:0035562","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0005977","count":2}]},{"hash":"20001483875466880","title":"Developmental mechanotransduction and adhesion","description":"This cluster is driven by developmental GO terms (hair follicle development, Sertoli cell proliferation) and mechanotransduction/adhesion terms (cellular response to mechanical stimulus, focal adhesion assembly), suggesting proteins involved in tissue development coordinated with mechanosensing and cell-ECM adhesion. A few low-count metabolic terms appear but are likely incidental noise. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001942","count":2},{"id":"GO:0048041","count":2},{"id":"GO:0060011","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0006579","count":1}]},{"hash":"368218953017294898","title":"Planar polarity and neuronal axon guidance","description":"The terms mostly point to planar cell polarity and neuronal guidance, including PCP establishment, axon guidance for dopaminergic and serotonergic neurons, and neuron migration; lung morphogenesis terms appear but PCP/axon guidance is the central theme, suggesting a PCP-guided neuronal development cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060490","count":2},{"id":"GO:0060488","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0036514","count":2},{"id":"GO:0001764","count":2}]},{"hash":"2135737858457005065","title":"Neuronal development and synaptic vesicle trafficking","description":"The top GO terms cluster around nervous system development and synaptic function: adult locomotory behavior, synaptic vesicle budding from presynaptic endocytic zone membrane, clathrin-dependent endocytosis, and midbrain morphogenesis. This points to proteins involved in neuronal development and vesicle trafficking at synapses. Other terms like maintenance of cell polarity and mitochondrial fission reflect broader cellular organization and energy dynamics that often accompany neurons. TORC2 and insulin receptor signaling may indicate broader signaling roles but do not contradict the neuronal theme. Overall, a cohesive theme is neuronal development and synaptic vesicle trafficking.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008344","count":3},{"id":"GO:1901998","count":3},{"id":"GO:0016185","count":3},{"id":"GO:0030011","count":3},{"id":"GO:0000266","count":2}]},{"hash":"1631561524607232100","title":"Histone methylation and chromatin silencing","description":"Proteins in this cluster are linked to histone methylation marks (H3K9me3, H3K4me3, H3K27me3, H4-K20me3) and to chromatin silencing/heterochromatin formation, including rDNA heterochromatin. The recurring GO terms point to regulation of chromatin state rather than primary signaling pathways, suggesting a shared role in establishing or maintaining repressive chromatin and epigenetic control.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":2},{"id":"GO:1900477","count":1},{"id":"GO:0036124","count":1},{"id":"GO:0080182","count":1},{"id":"GO:0031937","count":1}]},{"hash":"375109385886448288","title":"TCA Cycle and NADPH-Driven Redox Metabolism","description":"The top terms cluster around central carbon metabolism (TCA cycle, 2-oxoglutarate metabolism, glyoxylate cycle) and redox-related processes (NADPH regeneration, NADP+ biosynthesis, glutathione metabolism). This points to a cohesive theme of energy production and antioxidant capacity, with auxiliary terms like female gonad development and glial cell regulation likely representing annotation noise or context-specific roles. Overall, the proteins seem linked to core metabolic and redox pathways rather than a single specialized function.","confidence":"Medium","size":7,"edges":11,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":5},{"id":"GO:0006103","count":4},{"id":"GO:0006740","count":4},{"id":"GO:0006099","count":4},{"id":"GO:0006749","count":4}]},{"hash":"153227296661092741","title":"Diverse Biosynthesis of Amino Acids, Nucleotides, and Lipids","description":"Top GO terms indicate ectoine biosynthesis/catabolism, fatty acid oxidation/metabolism, histidine and purine biosynthesis, and a cAMP response. This spread points to involvement in multiple biosynthetic pathways rather than a single discrete function, so a broad label focusing on diverse biosynthesis is appropriate. The presence of ectoine and secondary metabolite biosynthesis terms (verruculogen) suggests mixed microbial contexts, but the shared theme remains metabolic biosynthesis.","confidence":"Medium","size":7,"edges":11,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042400","count":3},{"id":"GO:1902181","count":3},{"id":"GO:0001561","count":3},{"id":"GO:0097089","count":3},{"id":"GO:0019491","count":3}]},{"hash":"927617272707916659","title":"Cytoplasmic and Mitochondrial Translation","description":"The cluster is dominated by translation-related GO terms: cytoplasmic translation and initiation/elongation/termination, plus mitochondrial translation, indicating core protein-synthesis machinery activity. The presence of deadenylation-dependent decay and antibiotic-response terms further supports a link to ribosome function and mRNA turnover. A few-term outliers related to differentiation exist but do not define the main theme. Overall, the group reflects protein synthesis across both cytoplasmic and mitochondrial compartments.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0000288","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0014009","count":2}]},{"hash":"2094015251831118945","title":"Mitochondrial import and Complex IV assembly","description":"This cluster is dominated by GO terms for mitochondrial targeting and inner membrane insertion, plus assembly of the mitochondrial respiratory chain complex IV and proton/electron transport. These together point to a core function in mitochondrial protein import/localization and assembly of the respiratory machinery, i.e., energy metabolism. Some unrelated terms (ER organization, cell cycle regulation) appear but do not overwhelm the mitochondrial theme.","confidence":"High","size":7,"edges":7,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0072321","count":2},{"id":"GO:0045039","count":2},{"id":"GO:0006626","count":2},{"id":"GO:0042774","count":1},{"id":"GO:1902600","count":1}]},{"hash":"252284660693547293","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms tied to ribosome production and function: translation, ribosome biogenesis, SSU rRNA maturation, and small subunit assembly. Together, they indicate proteins involved in ribosome assembly and protein synthesis; a few items on splicing regulation and chromatin organization are minor exceptions but do not override the core ribosome/translation theme.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0000462","count":2},{"id":"GO:0000028","count":2},{"id":"GO:0048025","count":2}]},{"hash":"1504052663162516360","title":"Spliceosome- and mRNA processing cluster","description":"The top GO terms cluster around mRNA splicing via the spliceosome, alternative splicing, mRNA export, and mRNA stabilization, with connections to translation initiation and polyadenylation. This pattern points to a group of proteins involved in RNA processing and maturation, i.e., post-transcriptional regulation, rather than a single pathway; an incidental term like blastocyst formation is present but not defining. ","confidence":"High","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":7},{"id":"GO:0075525","count":4},{"id":"GO:0048025","count":4},{"id":"GO:0001825","count":4},{"id":"GO:0001731","count":4}]},{"hash":"1327362665328648761","title":"Inflammation and stress-response signaling","description":"This cluster shows enrichment for inflammatory response and response to antibiotic, along with redox and signaling processes (Notch, PDGF) and transcription, implying a module centered on cellular stress and immune signaling with some metabolic/lipid biosynthesis components.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0006107","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006954","count":2}]},{"hash":"1258306077919382108","title":"Thermogenic and cardiovascular-renal signaling","description":"The cluster shows strongest signals in thermogenesis and temperature response (diet-induced thermogenesis; cellular response to temperature stimulus) and in cardiovascular-renal regulation (renin-angiotensin\u2013mediated blood pressure regulation; regulation of glomerular filtration), suggesting a shared role in metabolic and renal/circulatory signaling. Some terms are related to membrane potential and pain perception, which may reflect broader neurometabolic context, but the dominant pattern supports thermogenic and renal/cardiovascular functions.","confidence":"Medium","size":7,"edges":8,"triangles":5,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0018298","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0071502","count":4}]},{"hash":"4354362357028913","title":"mRNA Splicing and Translation Initiation","description":"The top GO terms cluster around spliceosome-mediated mRNA processing (regulation and alternative splicing, mRNA export, small-subunit processome assembly) and components of translation initiation, indicating a group tied to post-transcriptional gene expression control from RNA maturation to initiation of translation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":5},{"id":"GO:0048025","count":5},{"id":"GO:0001825","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0048026","count":5}]},{"hash":"16187609038034648","title":"Transcriptional regulators of embryonic morphogenesis","description":"Reasoning: The cluster is enriched for transcription-related GO terms (RNA polymerase II\u2013mediated transcription and its negative regulation) and chromatin remodeling, plus several embryonic morphogenesis terms across multiple organs (eye, pancreas, neural crest, branching morphogenesis). This combination suggests the proteins function as transcriptional regulators coordinating embryonic organ development.","confidence":"High","size":7,"edges":9,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006366","count":4},{"id":"GO:0031018","count":3},{"id":"GO:0048557","count":3},{"id":"GO:0001755","count":3}]},{"hash":"349728934063748321","title":"Neurodevelopment and neuroimmune signaling","description":"These GO terms cluster around neural development and function: axonal fasciculation, otolith morphogenesis (sensory organ development), synapse assembly, and myelination point to nervous system formation and wiring; the cellular/innate immune terms (innate immune response, cytokine production) suggest potential neuroimmune interactions, with ubiquitination indicating protein regulation of signaling. Overall, the dominant theme is neural development with possible immune signaling involvement.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0032474","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0014068","count":3}]},{"hash":"1695775279912087141","title":"Innate Immunity and Host Defense Regulation","description":"The cluster is dominated by innate immune-related GO terms (innate immune response, complement activation, dendritic cell differentiation, macrophage regulation, tumor cell detection) and host interaction signals, suggesting an innate defense and immune regulation theme. A few outlier terms (lens morphogenesis, spermatid development) may reflect annotation noise or pleiotropy rather than a core function. Overall, the proteins appear grouped by immune defense roles with host interaction aspects.","confidence":"Medium","size":7,"edges":8,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0042493","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0043031","count":5},{"id":"GO:0002089","count":5}]},{"hash":"874043509365114852","title":"Developmental signaling and organogenesis","description":"The terms point to signaling pathways governing development and tissue formation (organ induction, metanephric mesenchyme migration, ossification, spermatid and auditory receptor development) with KIT and VEGF/PDGF signaling indicating growth during organogenesis. A few immune-related terms appear, but the dominant theme is developmental differentiation and organ formation across tissues.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002729","count":1},{"id":"GO:1903082","count":1},{"id":"GO:0038109","count":1},{"id":"GO:0035234","count":1},{"id":"GO:0001759","count":1}]},{"hash":"1588536991719595974","title":"Spermatogenesis with copper homeostasis and ROS response","description":"Top terms indicate germ cell development (spermatogenesis, oocyte construction) alongside copper ion homeostasis/transport and oxidative stress responses (ROS removal, hydrogen peroxide response) and stress signaling (MAPK cascade regulation). This pattern suggests a cohesive theme of germ cell maturation coupled with copper balance and oxidative stress management.","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007283","count":3},{"id":"GO:0007308","count":2},{"id":"GO:0022417","count":2},{"id":"GO:0018171","count":2},{"id":"GO:0006878","count":2}]},{"hash":"180986420539671307","title":"Steroid Biosynthesis and Reproductive Development","description":"This cluster is driven by multiple steroid biosynthetic and hormone-related processes (brassinosteroid, testosterone, progesterone) and tissue development terms (female genitalia and mammary gland development). A couple of detoxification and methylation terms are present but appear ancillary to the main steroid/hormone theme.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030540","count":5},{"id":"GO:0010268","count":5},{"id":"GO:0042448","count":5},{"id":"GO:0016132","count":5},{"id":"GO:0061370","count":5}]},{"hash":"1590329158850773822","title":"Immune signaling and transcription regulation","description":"The top GO terms point to transcriptional regulation (DNA-templated transcription), modulation of signaling pathways (positive regulation of GTPase activity), and immune-related processes (cellular response to TGF-beta, dendritic cell differentiation, macrophage inflammatory protein 1\u03b1 production). Together, these suggest a cluster of proteins involved in coordinating transcription and signaling in immune cells, though a few terms (e.g., suckling behavior, telomere binding) may reflect annotation noise or broader associations.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0000747","count":2},{"id":"GO:2001200","count":2}]},{"hash":"2032791187670738119","title":"Innate Immune Activation and Inflammation","description":"Based on the top GO terms, the cluster is enriched for innate immune responses and inflammatory signaling: cellular response to lipopolysaccharide, TLR9 signaling, inflammatory response, and positive regulation of macrophage cytokine and chemokine production. While several developmental terms (gonad, glomerulus, nipple, lung) appear among the terms, the strong presence of LPS/TLR pathways and cytokine/chemokine regulation anchors the cluster to innate immunity and inflammatory processes.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0071222","count":3},{"id":"GO:0034162","count":3},{"id":"GO:0072224","count":3},{"id":"GO:0006954","count":3}]},{"hash":"1466516566647881938","title":"DNA replication stress response and recombination repair","description":"The cluster\u2019s top GO terms cluster around replication fork problems (response to hydroxyurea, fork processing), homologous recombination processes (heteroduplex formation, DNA strand invasion, resolution of recombination intermediates), and DNA damage signaling (gamma radiation response), indicating a coherent module focused on detecting and repairing replication-associated DNA damage via HR pathways.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006268","count":2},{"id":"GO:0072711","count":2},{"id":"GO:1990426","count":2},{"id":"GO:0030491","count":2}]},{"hash":"727223999220925616","title":"Neural development and integrin signaling","description":"This cluster is dominated by neural development terms (forebrain/hippocampus development and excitatory postsynaptic potential) and integrin-mediated signaling, suggesting roles in neuronal differentiation and cell-adhesion\u2013driven signaling. Some terms also point to general cell-cycle and kinetochore localization, indicating mixed or broad cellular functions, but the neural development and adhesion-related signals are the most representative pattern.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007229","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0001707","count":3}]},{"hash":"204676579601713824","title":"Embryonic development and organogenesis","description":"This cluster gathers proteins linked to a broad set of embryonic development and tissue morphogenesis processes across multiple organs (inner ear, hypothalamus, pituitary, spinal cord, digestive tract, neural crest, ureteric bud branching, primitive streak formation). The dominant signal is embryonic patterning and organogenesis rather than a single pathway, with one general transcription regulation term present but not defining. ","confidence":"High","size":7,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0048839","count":4},{"id":"GO:0021854","count":4},{"id":"GO:0021521","count":4},{"id":"GO:0031018","count":4}]},{"hash":"131914250524529622","title":"Secretory vesicle trafficking and SNARE assembly","description":"This cluster's GO terms cluster around the secretory pathway: ER-to-Golgi transport, Golgi ribbon formation, Golgi-to-plasma membrane transport, vesicle fusion, and SNARE complex assembly, with supporting signals from neutrophil degranulation and histamine secretion. Together these indicate a cohesive role in vesicle trafficking and secretion.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0090161","count":3},{"id":"GO:0060291","count":2},{"id":"GO:1900483","count":2},{"id":"GO:0048280","count":2}]},{"hash":"2216725276402572811","title":"Ubiquitin-Dependent Transcription and RNA Processing","description":"Top GO terms center on ubiquitin-related regulation (deubiquitination, ubiquitin chain depolymerization, regulation of ubiquitin ligase activity) together with transcription and RNA processing (DNA-templated transcription, transcription regulation, mRNA processing). This suggests the proteins function as ubiquitin-mediated regulators of gene expression and RNA maturation, with potential links to chromatin-related deubiquitination and cell fate signaling. Confidence is moderate due to some terms being alternative processes not tightly connected to a single mechanism.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":2},{"id":"GO:0010995","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0006355","count":1}]},{"hash":"2212546797624006221","title":"GPCR-Driven Myeloid Immune Activation","description":"This cluster centers on GPCR signaling and myeloid immune activity. The top terms include GPCR signaling pathway, cell migration, and production of chemokines by macrophages, suggesting roles in immune cell trafficking and inflammatory signaling. Additional terms about cell growth and multicellular processes align with broader cellular responses, but the core theme is GPCR-driven activation and movement of myeloid cells.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0007049","count":4},{"id":"GO:1904743","count":3},{"id":"GO:0071642","count":3}]},{"hash":"274129392037614998","title":"Embryonic organogenesis and germ cell development","description":"These GO terms cluster around embryonic organogenesis and reproductive development\u2014organ induction, pronephric kidney development, metanephric mesenchyme migration, and spermatid development\u2014with KIT signaling commonly involved in developmental pathways; cell adhesion supports tissue organization. An immune-related term appears but does not define the cluster.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:2000566","count":1},{"id":"GO:0038109","count":1},{"id":"GO:0035157","count":1},{"id":"GO:0039021","count":1}]},{"hash":"900755739723840625","title":"Adhesion-driven epithelial and immune processes","description":"This cluster leans on cell\u2013cell adhesion terms (heterophilic and homophilic adhesion) and adhesion-regulated actin remodeling, plus proteins linked to epithelial development and integrity (lens morphogenesis, GI epithelium maintenance). It also includes immune-related functions (complement activation, macrophage activation regulation, tumor cell detection) and a host-interaction term (symbiont entry into host cell), suggesting a theme of adhesion-mediated signaling coordinating epithelial structure with immune surveillance and host interactions.","confidence":"Medium","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007156","count":7},{"id":"GO:0007286","count":6},{"id":"GO:0043031","count":6},{"id":"GO:0002089","count":6}]},{"hash":"2138186080396133777","title":"Migration and vesicle trafficking","description":"Based on the top GO terms, the cluster centers on cell movement (fibroblast migration) and intracellular transport/organellar organization (endosome and lysosome localization). Although there are signaling and reproductive remodeling terms (hippo signaling, luteinization), the strongest shared theme is cellular movement paired with vesicular trafficking. Thus, \u201cMigration and vesicle trafficking\u201d best captures the cluster\u2019s functional core.","confidence":"Low","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035332","count":1},{"id":"GO:0010761","count":1},{"id":"GO:0001553","count":1},{"id":"GO:0007032","count":1},{"id":"GO:0032418","count":1}]},{"hash":"1037848724040659717","title":"Renin-Angiotensin\u2013Renal Regulation","description":"Among the top GO terms, several point directly to renal and endocrine control of cardiovascular homeostasis: regulation of systemic arterial blood pressure by circulatory renin-angiotensin, regulation of glomerular filtration, and positive regulation of renin secretion. Additional terms about hormone secretion and smooth muscle contraction align with broader physiological regulation, while CD8-positive T cell differentiation and operant conditioning appear less connected and may reflect annotation noise or multifunction proteins. Overall, the cluster seems best described as renal endocrine regulation of blood pressure, with some peripheral terms.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":6},{"id":"GO:0035625","count":6},{"id":"GO:0001991","count":6},{"id":"GO:0002300","count":6},{"id":"GO:0003093","count":6}]},{"hash":"1425236540431165061","title":"ECM remodeling and connective tissue development","description":"The predominant terms point to extracellular matrix organization (collagen and fibronectin fibrils) and developmental processes affecting connective tissues (spinal cord development, chondrocyte differentiation, endothelial proliferation), suggesting proteins involved in ECM remodeling during tissue development. Some nuclear regulatory terms are present but do not override the main ECM/development theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051567","count":2},{"id":"GO:0030199","count":1},{"id":"GO:0046688","count":1}]},{"hash":"114842677517162844","title":"RNA processing and ribosome biogenesis","description":"The top GO terms cluster around spliceosome-mediated RNA processing (spliceosomal disassembly, mRNA splicing via spliceosome, RNA exon ligation) and ribosome biogenesis/rRNA maturation (ribosomal large subunit biogenesis, mitochondrial large subunit assembly, maturation of 5.8S and LSU rRNA), with additional RNA metabolism behavior like localization to cytoplasmic stress granules. Together they point to a functional module centered on RNA processing and assembly of ribosomal subunits.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000390","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0042273","count":4},{"id":"GO:1902775","count":4}]},{"hash":"1701855656957746920","title":"Neuronal differentiation and microtubule dynamics","description":"The cluster combines neuronal development signals (neuron differentiation and neuron migration) with strong microtubule-related processes (nucleation, cytoplasmic microtubule organization, mitotic spindle assembly) and cell division, suggesting proteins that coordinate neuronal maturation with cytoskeletal dynamics and mitosis. A concise theme is neuronal development linked to microtubule regulation.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1905789","count":7},{"id":"GO:0030182","count":7},{"id":"GO:0007020","count":7},{"id":"GO:0007049","count":7},{"id":"GO:2000767","count":7}]},{"hash":"1902507701068497402","title":"Calcium-Dependent Neuronal Signaling","description":"GO terms highlight calcium-dependent signaling in neural/sensory contexts\u2014calcineurin-NFAT signaling, synaptic vesicle endocytosis, and photoreceptor morphogenesis\u2014plus muscle activity response and membrane remodeling. While some terms are broader (chromatin binding regulation, cholesterol storage), the common thread is calcium-triggered signaling coordinating neuronal/sensory functions and remodeling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035191","count":1},{"id":"GO:0043950","count":1},{"id":"GO:0048488","count":1},{"id":"GO:0014850","count":1},{"id":"GO:0033173","count":1}]},{"hash":"1881544604696233323","title":"Membrane Nutrient Transporters","description":"The GO terms strongest in this cluster are various transmembrane transport processes for nutrients (glucose, biotin, pantothenate, myo-inositol) and sodium ions, suggesting a cohesive role in membrane transport of metabolites and ions. A few unrelated terms (blood coagulation, eating behavior, xenobiotic response) appear as outliers and do not define the core function, but the dominant theme is transport across membranes.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0042755","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0008292","count":1},{"id":"GO:0071436","count":1}]},{"hash":"1313027474429637845","title":"Cardiovascular development with inflammation and angiogenesis","description":"The top GO terms cluster around heart and vessel formation (atrioventricular node development, coronary artery morphogenesis, multicellular organism development) and endothelial/angiogenesis regulation, combined with inflammatory responses and mechanical stimulus signaling, suggesting a cohesive set of proteins involved in cardiovascular development, angiogenesis, and associated inflammatory remodeling.","confidence":"High","size":7,"edges":19,"triangles":25,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":7},{"id":"GO:0007275","count":7},{"id":"GO:1903588","count":7},{"id":"GO:0006954","count":7},{"id":"GO:0032496","count":7}]},{"hash":"974586231488919645","title":"Developmental signaling and transcriptional regulation","description":"This cluster centers on terms related to development (skin, multicellular organism development) and transcriptional control (DNA-templated transcription, regulation of transcription by TF localization), with inputs from growth hormone signaling and stress-responsive pathways (ER-stress\u2013induced apoptosis, GCN2 signaling). The absence of interaction edges suggests the proteins share functional themes rather than forming a single molecular complex. The label captures the overall flavor: development-associated signaling intertwined with transcriptional regulation and stress responses.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0035994","count":2},{"id":"GO:0043488","count":2}]},{"hash":"857457897164979773","title":"Adaptive immune signaling and hematopoietic development","description":"This cluster is enriched for adaptive immune signaling (B cell receptor, Fc\u03b5 receptor, IL-2 regulation, T cell receptor signaling) together with hematopoietic/megakaryocytic development (KIT signaling, megakaryocytes, angiogenesis), and related extracellular matrix processes (hyaluronan metabolism). The common theme is immune signaling linked to hematopoietic lineage development.","confidence":"High","size":7,"edges":8,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0002250","count":5},{"id":"GO:1900042","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0038095","count":5}]},{"hash":"1492467475392955674","title":"Host defense and pathogen entry","description":"The cluster includes GO terms tied to host\u2013pathogen interactions: entry of symbionts and viruses into host cells, defense responses to bacteria, and related processes like cytolysis and bacterial cell wall turnover, suggesting a cohesive theme around pathogen invasion and the host response.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":2},{"id":"GO:0016998","count":2},{"id":"GO:2000114","count":2},{"id":"GO:0051897","count":2},{"id":"GO:0019835","count":2}]},{"hash":"387901572639040739","title":"Cytokine-Mediated Immune Signaling","description":"The cluster's top GO terms are heavily enriched for immune-related pathways: cellular response to lipopolysaccharide, GM-CSF stimulus, T cell receptor signaling, and TNF production. While other terms touch on transcription, cell division, development, and neural activity, the dominant pattern centers on immune and cytokine signaling, suggesting these proteins collectively participate in inflammatory and adaptive immune responses with potential pleiotropy.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0032092","count":3}]},{"hash":"1441393418306410916","title":"Immune signaling and leukocyte adhesion","description":"This cluster is dominated by GO terms tied to inflammatory and immune processes: cytokine production (IL-6, IL-8), leukocyte adhesion to endothelium, lymph node development, and IgA isotype switching, plus podosome assembly related to immune cell movement. While a couple of terms are less directly related (hair follicle placode formation, glucose transport regulation), the overall pattern points to immune activation and interactions with the vasculature. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045416","count":1},{"id":"GO:0032755","count":1},{"id":"GO:0060789","count":1},{"id":"GO:0048535","count":1},{"id":"GO:2000334","count":1}]},{"hash":"2257739565756477747","title":"Unknown","description":"The terms include muscle development processes (myoblast differentiation, myotome development) alongside various membrane transport activities (sodium, nitrate, vitamin, sialic acid transport) and signaling/transcription regulation. The lack of explicit functional coherence and no edges among proteins suggests there isn't a single, interpretable theme to name this cluster; thus Unknown with no confidence.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001966","count":1},{"id":"GO:1901998","count":1},{"id":"GO:0045661","count":1},{"id":"GO:0030520","count":1},{"id":"GO:0061055","count":1}]},{"hash":"1426356113848677165","title":"Embryonic cardiac and neural development","description":"The GO terms point to early organogenesis, especially heart morphogenesis/heart field specification, and neural tube patterning, with additional embryonic development regulatory processes. Despite some generic/obsolete terms, the dominant theme is embryonic cardiac and neural development.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":3},{"id":"GO:0055010","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0045654","count":2},{"id":"GO:2001111","count":2}]},{"hash":"1121034943293336083","title":"Amino Acid Metabolism and Central Carbon Metabolism","description":"The top GO terms are dominated by amino acid catabolic and biosynthetic processes (L-valine and L-alanine, with both catabolic and biosynthetic mentions), plus related central carbon pathways like the pentose-phosphate shunt and glyoxylate metabolism. An outlier is a 6-sulfoquinovose catabolic process, and there is an unrelated term for potassium ion transport, suggesting a cluster of proteins with diverse metabolic roles rather than a single tight pathway. The main shared theme appears to be amino acid metabolism intertwined with core carbon metabolic routes, which justifies this label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006098","count":2},{"id":"GO:1902777","count":2},{"id":"GO:0009097","count":2}]},{"hash":"2109238036186921744","title":"Tubulin folding and microtubule organization","description":"This cluster is dominated by GO terms tied to tubulin folding and microtubule organization (post-chaperonin tubulin folding pathway; cytoplasmic microtubule organization), suggesting involvement in cytoskeletal assembly and maintenance. Additional terms related to nuclear membrane disassembly and maintenance of protein localization at the plasma membrane reflect aspects of cell architecture during division and trafficking, while a couple of immune signaling terms appear less central to the core theme.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007023","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0071642","count":2},{"id":"GO:0072321","count":2},{"id":"GO:0072660","count":2}]},{"hash":"1186263953194784117","title":"Oxidative Stress Response and Detoxification","description":"Based on GO terms, the cluster centers on detoxifying reactive oxygen species and responding to oxidative stress (e.g., cellular oxidant detoxification, hydrogen peroxide response/catabolism, removal of superoxide). There are also signs of stress-activated MAPK regulation, and a couple of reproductive development annotations that seem less connected, suggesting oxidative stress pathways dominate the cluster.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0022417","count":5},{"id":"GO:0018171","count":5},{"id":"GO:0019430","count":5},{"id":"GO:2000255","count":5}]},{"hash":"813597812429022311","title":"Unknown","description":"The terms span DNA replication, transcription regulation, protein refolding, stress granule disassembly, various membrane transport and amino acid homeostasis processes, plus bacterial flagellum assembly. The broad, mixed biology and inclusion of obsolete GO terms suggest no single cohesive function for this cluster, so a neutral Unknown label is most appropriate.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0035617","count":3},{"id":"GO:0006626","count":2},{"id":"GO:0090464","count":2}]},{"hash":"1672414793799677376","title":"Purine nucleotide metabolism and NAD biosynthesis","description":"The top terms are dominated by nucleotide metabolism: AMP salvage, ADP, CDP, and nucleoside monophosphate phosphorylation, purine ribonucleotide interconversion, and NAD+ biosynthesis, plus related ITP metabolism. This points to a cohesive function in nucleotide synthesis, salvage, and interconversion. Development terms like liver and brain appear incidental and not central to the core metabolic theme. ","confidence":"High","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0046939","count":6},{"id":"GO:0046041","count":6},{"id":"GO:0044209","count":6},{"id":"GO:0001889","count":6},{"id":"GO:0046705","count":6}]},{"hash":"1589926229909662955","title":"Translation machinery and ribosome biogenesis","description":"The terms are dominated by translation and ribosome-related processes: translation, ribosomal large subunit assembly, maturation of SSU-rRNA, and mitochondrial translation, with notes on translational fidelity. These together point to a cluster of proteins involved in ribosome biogenesis and protein synthesis, with fidelity regulation as a supporting theme; minor terms like deadenylation and glial proliferation are less central. ","confidence":"High","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000027","count":2},{"id":"GO:0000462","count":1},{"id":"GO:0006449","count":1},{"id":"GO:0046677","count":1}]},{"hash":"2108435367774684850","title":"Glycan and lipid biosynthesis","description":"This cluster is dominated by terms related to synthesis and processing of glycans and lipids, such as O antigen biosynthesis, UDP-sugar biosynthetic pathways, wax biosynthetic process, and long-chain fatty-acyl-CoA metabolism. While a couple of terms reference development, the recurring theme across the top GO terms points to carbohydrate and lipid biosynthesis. Confidence reflects this majority signal, with some outliers likely due to annotation noise or broad functional links. ","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0051216","count":3},{"id":"GO:0009243","count":2},{"id":"GO:0033499","count":2},{"id":"GO:0010025","count":2}]},{"hash":"131802524682388439","title":"Signaling and Hormonal Regulation","description":"The terms point to various signaling activities: activation of protein kinase activity, GPCR-related signaling, and cAMP signaling, along with hormonal control elements such as regulation of renin secretion and renin-angiotensin\u2013mediated blood pressure. A few terms (ribosome biogenesis, certain differentiation processes) are outliers, suggesting multifunctional proteins or broad functional annotations. Overall, the common theme is regulatory signaling for hormonal and vascular functions, justifying this label with a moderate level of confidence.","confidence":"Medium","size":6,"edges":9,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0032147","count":1},{"id":"GO:0043950","count":1},{"id":"GO:0035625","count":1},{"id":"GO:0001991","count":1}]},{"hash":"1004177772947080594","title":"Unknown","description":"Six proteins show a mix of GO terms spanning feeding regulation, ciliary motility, protein modification, retinoic acid signaling, transmembrane transport, digestion and secretion, excretion, intercellular transport, pancreatic secretion, and tooth development. There is no single coherent theme or dominant shared function linking these terms, so a specific, representative label cannot be assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000253","count":1},{"id":"GO:0060296","count":1},{"id":"GO:0018095","count":1},{"id":"GO:0032526","count":1},{"id":"GO:0035378","count":1}]},{"hash":"2134998297286285225","title":"RNA Processing and mRNA Decay","description":"This cluster centers on RNA maturation and turnover, with strong representation for tRNA processing, rRNA maturation, spliceosome and P-body\u2013related activities, and mRNA decapping/decay, plus transcription termination. A few stress-responsive terms (ABA, water deprivation) are present but do not define the core function.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":4},{"id":"GO:0030490","count":3},{"id":"GO:1990141","count":3},{"id":"GO:0033962","count":3},{"id":"GO:0006369","count":3}]},{"hash":"914971909907869874","title":"Organ Development and Regeneration","description":"The top GO terms are dominated by developmental processes, including animal organ regeneration (3) and nervous system development (3), with bone development also represented. This suggests a theme centered on tissue and organ development and regenerative capacity, even though some other terms (DNA repair, metabolic biosynthesis) are present but less defining. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031100","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0043086","count":2},{"id":"GO:0031505","count":2}]},{"hash":"2264352426034622019","title":"Triglyceride catabolism and lipid remodeling","description":"This cluster is dominated by GO terms for triglyceride catabolic processes, triglyceride mobilization, and lipid remodeling (phosphatidylcholine and phosphatidylethanolamine catabolic processes), with an additional link to glucose homeostasis. Together, they point to a lipid-breakdown/energy-balance theme, with a hint of signaling regulation via PKA. Overall, the proteins seem to cluster around lipid metabolism and energy homeostasis rather than a single specific enzyme complex.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036153","count":1},{"id":"GO:0034638","count":1},{"id":"GO:2000480","count":1},{"id":"GO:0010898","count":1},{"id":"GO:0006642","count":1}]},{"hash":"1752535694731816548","title":"Organelle Dynamics and Autophagy Machinery","description":"The cluster centers on mitochondrial fission, tubulin complex assembly, and protein localization to phagophore assembly sites, pointing to a core theme of cellular organization and organelle dynamics; additional terms touch on related development and signaling contexts but still align with structural and autophagy-related processes.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":6},{"id":"GO:0000266","count":6},{"id":"GO:0009740","count":6},{"id":"GO:0060789","count":6},{"id":"GO:0014045","count":6}]},{"hash":"1806487120964553084","title":"ECM remodeling and cell migration","description":"These terms cluster around extracellular matrix remodeling, cell movement, and tissue growth (collagen catabolic process, leukocyte and keratinocyte migration, ossification, and regulation by extracellular stimuli). While there isn\u2019t a single dominant function and a few terms are obsolete, the common thread is involvement in ECM remodeling and related migratory processes, suggesting proteins that modulate the extracellular environment and cell movement.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900122","count":1},{"id":"GO:0030574","count":1},{"id":"GO:2001268","count":1},{"id":"GO:0051549","count":1},{"id":"GO:0050900","count":1}]},{"hash":"969635703171030912","title":"Unknown","description":"The top terms are very diverse: translation (GO:0006412) appears for a few proteins, but there are also multiple, seemingly unrelated ion transport and regulatory processes (cadmium, sodium, copper transport; calcium homeostasis; membrane repolarization; cardiac hypertrophy regulation). This scattered mix provides no single coherent functional theme for the cluster.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0043066","count":2},{"id":"GO:0070574","count":1},{"id":"GO:0036376","count":1},{"id":"GO:0006874","count":1}]},{"hash":"1663290202807416027","title":"Ubiquitin-Mediated Antiviral Defense","description":"This cluster is enriched for ubiquitin-dependent processes (ERAD, polyubiquitination) alongside innate immune and antiviral activities (innate immune response, defense against virus, suppression of viral release). The combination points to a theme of ubiquitin-proteasome\u2013mediated degradation linked to host antiviral defense, with ancillary immune-regulatory terms.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0051607","count":4},{"id":"GO:1902187","count":3}]},{"hash":"1623246351995903317","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":8,"triangles":5,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008306","count":6},{"id":"GO:0034476","count":5},{"id":"GO:0006268","count":5},{"id":"GO:0070870","count":5},{"id":"GO:0000390","count":5}]},{"hash":"518475493862694771","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021957","count":4},{"id":"GO:0072300","count":3},{"id":"GO:0086073","count":3},{"id":"GO:0003273","count":3},{"id":"GO:0060243","count":3}]},{"hash":"1252342379485811034","title":"Cellular stress response and genome maintenance","description":"The top GO terms include negative regulation of ER stress-induced apoptotic signaling, nucleotide-excision repair (both general and global genome repair), heat acclimation, insecticide response, and regulation of proteasomal protein degradation. Together these point to processes that preserve cell viability under stress and maintain genome integrity. Other terms like ribosomal subunit assembly or cardiac muscle contraction appear peripheral, but the dominant theme across the cluster is cellular stress response and maintenance of protein and genome integrity.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":6},{"id":"GO:0006289","count":6},{"id":"GO:1902260","count":6},{"id":"GO:0086004","count":6},{"id":"GO:0070911","count":6}]},{"hash":"1391544484047196013","title":"Embryonic organ morphogenesis","description":"The proteins cluster around developmental morphogenesis across multiple organs (prostate, eye, heart/outflow tract, placenta, hindlimb, gonad, habenula), reflecting a common theme of embryonic organ formation. While one term notes general transcriptional regulation, the dominant pattern is organogenesis during development, justifying the label.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060527","count":6},{"id":"GO:2000288","count":6},{"id":"GO:0048048","count":6},{"id":"GO:0008584","count":6},{"id":"GO:0007507","count":6}]},{"hash":"1759816336160832332","title":"Embryonic Development and Organogenesis","description":"The cluster is dominated by embryogenesis and organ formation signals\u2014terms like in utero embryonic development, pancreas morphogenesis, vagina development, and forebrain generation of neurons indicate developmental and neurodevelopmental processes, supported by multicellular growth and transcriptional regulation. Some cholesterol homeostasis and bile acid metabolism terms may reflect broader maturation, but the core theme is developmental regulation.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060068","count":3},{"id":"GO:0061113","count":3},{"id":"GO:0001701","count":3},{"id":"GO:1901522","count":3},{"id":"GO:0071222","count":3}]},{"hash":"12365644843237301","title":"Ubiquitin-dependent proteolysis and signaling","description":"The cluster is dominated by ubiquitination-related GO terms (autoubiquitination, ubiquitin-dependent protein catabolic process, K63-linked ubiquitination, ERAD), indicating a core function in tagging and degrading proteins, with related signaling implications (MAPK cascade, growth hormone response). Some terms like telomere maintenance and viral translation reinitiation appear as outliers, but the strongest signal is ubiquitin-mediated regulation, making this label representative.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0032212","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0030433","count":3}]},{"hash":"2146160406616112785","title":"Multicellular development and organ formation","description":"The top GO terms are dominated by developmental processes such as gastrulation, brain development, skin development, and multicellular organism development, indicating a theme of organismal development. A few outlier terms (glycolytic process, propylene catabolic process, plasma membrane repair, sperm capacitation) are more metabolic or maintenance-related, but they are fewer in number and do not override the developmental signal. Therefore the cluster most plausibly groups proteins involved in embryonic and tissue development across organs.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0001778","count":2},{"id":"GO:0030433","count":2}]},{"hash":"2128992853106752489","title":"Neural and Inner Ear Development with Tissue Remodeling","description":"The terms point to neural development and sensory organ morphogenesis (neural tube closure, axon guidance, inner ear development) and to tissue remodeling processes (wound healing, regulation of cell growth, senescence, and transcriptional/epigenetic control), suggesting a coherent program governing neural/ear morphogenesis and repair.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048146","count":2},{"id":"GO:0048839","count":2},{"id":"GO:1904706","count":2},{"id":"GO:0030308","count":2},{"id":"GO:0090398","count":2}]},{"hash":"1209894668743218889","title":"Unknown","description":"The GO terms span translation, stress response, various development processes, signaling, and nuclear/export regulation with no clear, shared function tying the proteins together; the sparse connections and inclusion of obsolete terms suggest a non-cohesive or misannotated cluster. ","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":1},{"id":"GO:0034599","count":1},{"id":"GO:2000384","count":1},{"id":"GO:0010991","count":1},{"id":"GO:0035970","count":1}]},{"hash":"2040561428198515042","title":"Mesoderm formation and stem cell differentiation","description":"The top GO terms point to mesoderm formation, stem cell differentiation, and cell cycle/proliferation signals (DNA-templated transcription, nuclear DNA replication, VEGF/PDGF signaling), plus ECM remodeling, all of which align with developmental progression from stem cells into mesodermal lineages and accompanying proliferation. This combination suggests a cluster centered on mesoderm development with associated proliferative cues.","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":6},{"id":"GO:0014850","count":6},{"id":"GO:2000738","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0001707","count":6}]},{"hash":"1347566623389498351","title":"Vesicle trafficking and exosome secretion","description":"The strongest signals areGolgi vesicle budding and exosomal secretion, pointing to a secretory/vesicle-based role, with protein heterooligomerization suggesting assembly of protein complexes; other terms hint at broader development processes, but the core theme is secretory vesicles and trafficking. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048194","count":5},{"id":"GO:1902766","count":5},{"id":"GO:0035690","count":5},{"id":"GO:0051291","count":5},{"id":"GO:0016358","count":5}]},{"hash":"1453740460852405244","title":"Mitochondrial translation and aminoacyl-tRNA synthetases","description":"The cluster is driven by mitochondrial-specific translation and aminoacylation terms (mitochondrial tryptophanyl-, tyrosyl-, and valyl-tRNA aminoacylation) along with general translation, plus associated mitochondrial metabolic processes (NAD+/CoA biosynthesis), suggesting a cohesive role in mitochondrial protein synthesis and related metabolism. Angiogenesis terms appear incidental to core function.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0046940","count":1},{"id":"GO:0009435","count":1},{"id":"GO:0046939","count":1}]},{"hash":"1301191936590408532","title":"Auditory system signaling and myelination","description":"The terms strongly point to auditory nerve signaling and neural myelination, with multiple GO terms about sound perception and for myelination, plus supportive neuronal signaling pathways. A couple terms appear less related (amyloid fibril formation, placental branching morphogenesis) and may reflect annotation noise or multifunctional proteins, but the core theme remains hearing-related neural function. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0007605","count":2},{"id":"GO:1990000","count":1},{"id":"GO:0051563","count":1}]},{"hash":"773384624468735949","title":"Hippocampal neuronal signaling and axon extension","description":"Rationale: Several terms point to neuronal communication and development (ephrin receptor signaling, Wnt signaling, dopamine response, excitatory postsynaptic potentials) and to hippocampal development and axon growth, suggesting a coherent theme of hippocampal neuron signaling and axon extension, despite some noise like mitotic cell cycle terms.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048013","count":5},{"id":"GO:0000186","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0021766","count":5},{"id":"GO:0060079","count":5}]},{"hash":"823932116531788927","title":"Unknown","description":"The_top terms include a mix of innate immune response, plant photoreceptor/light signaling (red/far red), jasmonic acid signaling, flower development, chromatin regulation, antimicrobial peptide biosynthesis, and neural guidance, with no common function linking them. The cluster has no edges or connectivity, and the annotations span both animal and plant contexts, making a cohesive functional theme unlikely. Therefore, Unknown with no confident representative label.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0008045","count":2},{"id":"GO:0010114","count":1},{"id":"GO:0009911","count":1},{"id":"GO:0071158","count":1}]},{"hash":"557982129820560299","title":"Inflammatory signaling and ion homeostasis","description":"This cluster features GO terms centered on inflammatory and stress signaling (TNF-mediated signaling, NF-kappaB regulation, cellular response to LPS, and p53-related apoptotic pathways) alongside terms for ion transport and calcium homeostasis (sodium/potassium transport, calcium ion homeostasis, cardiac muscle relaxation). The combination suggests a broad stress/inflammatory response module that links signaling cascades with ion regulation, rather than a highly specific single function. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034051","count":1},{"id":"GO:0042771","count":1},{"id":"GO:0033209","count":1},{"id":"GO:0042347","count":1},{"id":"GO:0071222","count":1}]},{"hash":"567590213589807521","title":"PI3K-Akt Growth Signaling Modulators","description":"The top GO terms point to positive regulation of PDGF receptor signaling and PI3K/AKT signaling, indicating involvement in growth factor\u2013driven signal transduction. Other terms touch on protein targeting and stress responses, consistent with regulators that influence signaling by modulating localization and folding. The small cluster size and modest connectivity suggest these are modulatory proteins rather than core signaling components. Therefore, this label captures the central theme of growth factor\u2013related signaling regulation with ancillary localization and stress-related roles.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010641","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0031204","count":2},{"id":"GO:0006626","count":2},{"id":"GO:0001707","count":2}]},{"hash":"944152421031428240","title":"ECM adhesion and remodeling","description":"The GO terms point to extracellular matrix interactions and adhesion signaling (integrin signaling, hyaluronan metabolism, adhesion-dependent spreading, metallopeptidase activity) as a unifying theme, with development-related processes like endodermal differentiation and axon guidance supporting a morphogenetic context. A few outliers (e.g., chlorophyll biosynthesis) likely reflect annotation noise. Overall, the cluster centers on adhesion and ECM remodeling.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":3},{"id":"GO:1905050","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0030212","count":3},{"id":"GO:0031532","count":3}]},{"hash":"9152785734897979","title":"Unknown","description":"The top GO terms point to several unrelated processes (cell division/mitosis, mRNA splicing, mitochondrial complex assembly, ER-associated glycoprotein processing and retrograde transport). There is no single dominant function that ties these proteins together, suggesting heterogeneous or noisy annotations. Therefore a universal label is not confidently representational.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":1},{"id":"GO:0000245","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0000278","count":1},{"id":"GO:0033108","count":1}]},{"hash":"1526372352849558333","title":"Spliceosome Assembly and mRNA Processing","description":"This cluster is dominated by spliceosome- and mRNA processing-related terms (spliceosomal tri-snRNP assembly, RNA splicing, mRNA processing), indicating a core role in RNA processing and splicing. Some viral translation and export terms appear, suggesting possible moonlighting roles, but the primary signal is RNA splicing/processing.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000244","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0045292","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0075525","count":1}]},{"hash":"1146699367145222749","title":"Endocytosis and Endosome\u2013Lysosome Trafficking","description":"This cluster is strongly enriched for GO terms related to endocytosis (GO:0006897), clathrin-dependent endocytosis (GO:0072583), and endosome transport (GO:0034498, GO:0032511), with related terms like protein targeting to vacuole and endosome-to-Golgi transport. These point to a cohesive function in vesicle trafficking and endocytic pathways, with some auxiliary terms (e.g., EGFR signaling regulation) that can be modulated by trafficking processes. Overall, the data suggest a vesicle trafficking/endocytosis role as the core theme. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060453","count":3},{"id":"GO:1902961","count":3},{"id":"GO:0034498","count":3},{"id":"GO:0032511","count":3},{"id":"GO:0098711","count":3}]},{"hash":"233475748931678107","title":"Angiogenesis and immune signaling","description":"This cluster's top GO terms cluster around vascular and immune signaling processes, including angiogenesis (GO:0001525), VEGF/PDGF-related signaling and receptor pathways, Fc receptor signaling, STAT phosphorylation, and neutrophil clearance, as well as IL-3 production regulation. A few terms also touch on neural signaling (synapse localization, axon guidance), suggesting broader roles in cell\u2013cell communication. Overall, the coherent theme centers on growth-factor\u2013driven angiogenesis coupled with immune response signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035418","count":5},{"id":"GO:0008045","count":5},{"id":"GO:0038091","count":4},{"id":"GO:0097067","count":4},{"id":"GO:0097350","count":4}]},{"hash":"607753359673084407","title":"Embryonic Development & Morphogenesis","description":"The top GO terms cluster around embryonic development, tissue morphogenesis, patterning, and differentiation across various tissues (placenta, mesoderm, hair follicles, endocrine pancreas), indicating a broad developmental role rather than a single tissue-specific function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0035270","count":5}]},{"hash":"1516092468205865634","title":"DNA replication and genome maintenance","description":"The top GO terms are dominated by DNA metabolism: DNA-templated transcription, DNA replication, DNA repair, and mitotic cell cycle, all pointing to genome maintenance and replication control. While a few terms relate to ribosome assembly and catabolic processes, the dominant signal ties to genome stability and cell-cycle regulation, justifying this label.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0070651","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0006260","count":2}]},{"hash":"636858350437225233","title":"Neural development and synaptic plasticity signaling","description":"The cluster shows a strong enrichment for neuronal growth and synaptic remodeling processes: dendritic spine morphogenesis; positive regulation of ERK1/ERK2 cascade and PI3K/AKT signaling; and regulation of serine phosphorylation, all core to neural development and synaptic plasticity. Additional terms such as behavioral response to cocaine and response to toxic substances point to neural signaling and activity. Together, these terms suggest proteins involved in neural development and activity-dependent synaptic signaling.","confidence":"High","size":6,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0051897","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0060997","count":5}]},{"hash":"1734369361000705270","title":"Regulation of stress signaling and apoptosis","description":"This cluster centers on regulatory roles across stress- and immune-related signaling pathways, including negative regulation of apoptosis, JNK/necrotic signaling, TLR pathway regulation, Rho signaling, nitric oxide response, and ubiquitination-linked transcriptional control. The shared theme is modulation of multiple signaling processes under cellular stress and immune contexts, rather than a single pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0034121","count":2}]},{"hash":"1918857734600649939","title":"ER stress and ER-to-Golgi trafficking","description":"Top terms point to ubiquitin-dependent ERAD, ER stress\u2013induced apoptotic signaling, and ER-to-Golgi vesicle transport, supported by microtubule-based movement and severing; together these suggest a cluster focused on ER quality control and cytoskeletal trafficking, with some nuclear/chromatin/transcription terms likely reflecting multi-function proteins or annotation noise.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0070059","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0007018","count":3}]},{"hash":"640582924766035495","title":"Hormone signaling and metabolic regulation","description":"This cluster centers on hormone-related signaling and metabolic regulation, with terms for estrogen response, insulin signaling, steroid biosynthesis, and fatty acid metabolism, plus calcium signaling and membrane trafficking.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006694","count":1},{"id":"GO:0010524","count":1},{"id":"GO:0034141","count":1},{"id":"GO:0008286","count":1},{"id":"GO:0033138","count":1}]},{"hash":"756755767799708349","title":"DNA Repair and Mitotic Regulation","description":"The top GO terms cluster around mitosis and genome maintenance: G2/M transition, chromosome segregation, exit from mitosis, spindle assembly checkpoint deactivation, and multiple DNA repair processes (NER, postreplication repair, ubiquitin-proteasome\u2013mediated protein turnover). This suggests the proteins function together to preserve genome integrity during cell division. A few terms related to viral processes or neuron development are present but appear peripheral to the dominant theme.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0016032","count":6},{"id":"GO:0000086","count":6},{"id":"GO:0007059","count":6},{"id":"GO:0070911","count":6},{"id":"GO:0031146","count":6}]},{"hash":"982440089171555513","title":"Neural and forebrain development","description":"This cluster is dominated by GO terms related to neural development and brain patterning, including forebrain formation, subpallium development, peripheral nervous system neuron development, and forebrain cell proliferation, with additional related terms like negative regulation of glial differentiation. Although a couple of terms touch other tissues (bronchiole development, pancreatic A cell development), the overarching pattern points to neural development and brain regional specification.","confidence":"High","size":6,"edges":11,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0021920","count":6},{"id":"GO:0003322","count":6},{"id":"GO:0021905","count":6},{"id":"GO:0060435","count":6},{"id":"GO:1902723","count":6}]},{"hash":"714811126936221826","title":"Ubiquitin-mediated protein degradation and mitotic control","description":"The leading GO terms emphasize ubiquitin-dependent proteolysis and ubiquitination, including K63-linked ubiquitination, along with mitotic/spindle checkpoint related processes and growth regulation. This suggests the proteins cluster around ubiquitin signaling that governs protein turnover and cell division, despite some obsolete terms. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:1901536","count":2},{"id":"GO:0070535","count":2},{"id":"GO:1903721","count":2},{"id":"GO:0046621","count":2}]},{"hash":"1329188282730931111","title":"Retinal neuron development and dopamine regulation","description":"The top GO terms point to retina development and neuron projection development, with regulation of dopamine metabolism also present. This combination suggests a developmental program for retinal neurons, potentially including dopaminergic signaling, supported by related terms on transcription, signaling regulation, and protein interactions. Therefore, a label emphasizing retinal neuron development with dopamine regulation is fitting and representative of the cluster's functions.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042053","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060041","count":3}]},{"hash":"814876835444055727","title":"Integrin-mediated adhesion and ECM remodeling","description":"The top terms converge on integrin-mediated signaling, calcium-independent cell-matrix and heterotypic cell-cell adhesion, cellular extravasation, and processes that remodel the extracellular matrix (e.g., metallopeptidase activity regulation, ECM assembly). This suggests proteins involved in attachment to the matrix, signaling through adhesion receptors, and ECM remodeling to enable migration or extravasation. A couple of terms (chlorophyll biosynthesis, proteasome assembly) seem peripheral, but the main signal points to adhesion and matrix dynamics.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007161","count":5},{"id":"GO:0035987","count":5},{"id":"GO:0007229","count":5},{"id":"GO:0045123","count":5},{"id":"GO:0034113","count":5}]},{"hash":"1673549235631316593","title":"Cerebellar neuron development and transcription regulation","description":"Top GO terms indicate cerebellar-specific developmental processes (granule cell precursor proliferation, Purkinje cell migration and maturation, branching morphogenesis of a nerve) alongside transcriptional regulation terms, suggesting these proteins coordinate cerebellar neuron development with transcriptional control. The mix points to a cohesive theme of cerebellar development influenced by transcription regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":1},{"id":"GO:0021930","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0048755","count":1},{"id":"GO:0031937","count":1}]},{"hash":"909401711958030707","title":"Skin lipid barrier and cholesterol metabolism","description":"The cluster features several lipid- and cholesterol-related processes (lipid digestion, reverse cholesterol transport, positive regulation of cholesterol storage) along with establishment of the skin barrier and lipoxin B4 biosynthesis, hinting at a shared theme of lipid processing and epidermal barrier formation. Some terms appear unrelated noise (brain segmentation, encapsulation of foreign target), but the dominant signals point to skin lipid metabolism and barrier integrity.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035010","count":1},{"id":"GO:0035284","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0006049","count":1},{"id":"GO:2001306","count":1}]},{"hash":"1367954105770404833","title":"C-Type Lectin Receptor\u2013Mediated Antifungal Response","description":"The top terms strongly point to innate immune recognition of fungi via C-type lectin receptors, including lectin pathway\u2013mediated complement activation, fungal-origin sensing, basophil activation, phagocytosis recognition, and arachidonic acid\u2013driven inflammatory responses. While kidney development terms appear, the immune-related GO terms dominate, suggesting a module involved in antifungal innate immunity driven by lectin receptors.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0045575","count":2},{"id":"GO:0071226","count":2},{"id":"GO:0060355","count":2},{"id":"GO:0090238","count":2}]},{"hash":"1324688807637416997","title":"Vesicle trafficking and endosome transport","description":"Based on the top GO terms, the proteins cluster around intracellular vesicle transport pathways, including COPII-coated vesicle budding, Golgi-to-ER retrograde transport, and endosome-to-lysosome routing, plus endosome maturation. While ossification and growth terms appear, the strongest cohesive signal is vesicle trafficking between organelles, making this the most representative single-theme label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000278","count":2}]},{"hash":"458714811339887088","title":"Secretory vesicle trafficking","description":"Based on GO terms dominated by vesicle trafficking and exocytosis (vessicle fusion with Golgi/vacuole, endosome-to-Golgi transport, acrosome reaction, norepinephrine secretion, and synaptic potentiation), these proteins likely function in secretory pathways and vesicle-mediated release. The presence of related membrane localization and adhesion terms further supports a trafficking-to-membrane role rather than a single organelle-specific function.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:2000010","count":1},{"id":"GO:0010811","count":1},{"id":"GO:0060291","count":1},{"id":"GO:0007340","count":1},{"id":"GO:0048280","count":1}]},{"hash":"700668427422564998","title":"Core metabolism and energy production","description":"This cluster\u2019s top GO terms cluster around central energy metabolism and cofactor biosynthesis (thiamine biosynthetic process, lipoate and tetrahydrofolate metabolism, glycolytic process, NADH to ubiquinone electron transport, dihydrolipoamide metabolism). These processes connect glycolysis to mitochondrial respiration and cofactor turnover, suggesting a group of enzymes dedicated to energy production and essential cofactor pathways rather than signaling or structural roles. The occasional unrelated term (sperm capacitation) may reflect annotation noise, but the dominant pattern supports energy metabolism.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":3},{"id":"GO:0006096","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0006120","count":2}]},{"hash":"53215556452123207","title":"Unknown","description":"The Top Terms show a mix of mitochondrial energy work (GO:0006120) and various RNA processing, transcription, lipid catabolism, and signaling terms. With only one edge and a broad spread of functions, there isn\u2019t a clear unifying theme to assign a specific, representative label. Therefore, Unknown is appropriate.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0000290","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0009154","count":1}]},{"hash":"743139019213485117","title":"Unknown","description":"Unknown - no clear common function unites the GO terms; terms span chromatin organization, transcription, translation, viral replication, collagen catabolic process, and stress responses, and the graph is tiny with little connectivity, suggesting a heterogeneous set rather than a coherent pathway.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034724","count":1},{"id":"GO:0035551","count":1},{"id":"GO:0034396","count":1},{"id":"GO:0030574","count":1},{"id":"GO:0046677","count":1}]},{"hash":"2174830149759934097","title":"Neurodevelopment and Synaptic Signaling","description":"The cluster is enriched for neural-related terms such as visual perception, memory, and excitatory postsynaptic potential, complemented by broader developmental and cellular processes (cell morphogenesis, transcription, replication, phosphorylation, and apoptotic regulation). This suggests proteins involved in neurodevelopment and synaptic signaling, though the presence of a term like karyogamy may reflect annotation noise or cross-species mappings rather than a shared neural function.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1432471784536962140","title":"Actin-driven cytoskeleton remodeling and endocytosis","description":"The proteins cluster around actin cytoskeleton dynamics, including polymerization/branching and podosome assembly, as well as endocytosis and adhesion-dependent spreading. The inclusion of ephrin, Wnt, and T cell receptor signaling terms suggests regulation of these cytoskeletal processes by diverse signaling pathways, and the presence of synapse plasticity terms points to roles at immune and neural interfaces.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071803","count":3},{"id":"GO:0043652","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0050852","count":3}]},{"hash":"1159319286684827555","title":"Antiviral host defense and ubiquitination signaling","description":"This cluster centers on immune responses to viruses and regulation of signaling pathways, as seen in GO terms for suppression of viral release/transcription, lymph node development, and negative regulation of germinal center formation. The presence of ubiquitination-related terms (K63-linked and linear polyubiquitination) and NF-kappaB regulation suggests a mechanism by which host cells modulate antiviral gene expression and immune signaling, often in lymphoid contexts.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1902187","count":3},{"id":"GO:0048535","count":3},{"id":"GO:0002635","count":3},{"id":"GO:0009896","count":3},{"id":"GO:0046597","count":3}]},{"hash":"420193665328382390","title":"Cardiac Action Potential and Membrane Potential Regulation","description":"The top GO terms cluster around cardiac electrical activity: action potential in cardiac muscle, heart-rate regulation via conduction, resting potential and repolarization, and potassium transport, forming a coherent theme of cardiac electrophysiology; a few temperature/pain terms appear incidental.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0086002","count":2},{"id":"GO:0086091","count":2},{"id":"GO:1990573","count":2},{"id":"GO:0060075","count":2},{"id":"GO:0098914","count":2}]},{"hash":"862447862311137305","title":"Ubiquitin-Dependent Protein Degradation (SCF)","description":"The top GO terms are dominated by ubiquitin-dependent catabolic processes, including SCF complex assembly and ubiquitin-mediated degradation via the multivesicular body sorting pathway, which together point to components of the ubiquitin-proteasome system and E3 ligase activity. Although a few terms touch on broader regulatory roles (e.g., histone ubiquitination, growth regulation), the core signal is clear: proteins here are linked to ubiquitin tagging and proteolysis, with SCF being a key ubiquitin ligase complex. Confidence is high that this label reflects the cluster\u2019s primary function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0010265","count":2},{"id":"GO:0043162","count":2},{"id":"GO:0070535","count":2},{"id":"GO:1902187","count":2}]},{"hash":"1417712575263159314","title":"Developmental and Immune Regulation","description":"Top GO terms point to roles in tissue development (skin development, otic vesicle formation, stem cell differentiation) and immune signaling (positive regulation of type 2 immune response, macrophage cytokine production), with additional hints at angiogenesis control and signaling modulation. This suggests these proteins act as broad regulators connecting development with immune responses, rather than a single specific function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0002830","count":1},{"id":"GO:0043518","count":1},{"id":"GO:2000738","count":1},{"id":"GO:0048671","count":1}]},{"hash":"428644073092933027","title":"Renin\u2013Angiotensin\u2013Hormone Regulation in Kidney","description":"The top GO terms converge on renal endocrine control: regulation of systemic arterial blood pressure via the renin\u2013angiotensin pathway, regulation of renin secretion, and regulation of glomerular filtration, along with hormone secretion. While a few terms hint at broader signaling or unrelated processes, the kidney-focused hormonal and blood-pressure regulation theme best explains the cluster.","confidence":"Medium","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":5},{"id":"GO:0035625","count":5},{"id":"GO:0001991","count":5},{"id":"GO:0002300","count":5},{"id":"GO:0003093","count":5}]},{"hash":"591550252663794710","title":"Renin-angiotensin-renal hormone regulation","description":"Based on the strongest recurring GO terms, the proteins cluster around regulation of blood pressure via the renin-angiotensin system, renin secretion, glomerular filtration, and hormone secretion, all pointing to renal-endocrine control of cardiovascular homeostasis. Some terms appear as outliers or obsolete annotations (e.g., T cell differentiation, operant conditioning), but the core theme remains renal and hormonal regulation of cardiovascular function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":5},{"id":"GO:0035625","count":5},{"id":"GO:0001991","count":5},{"id":"GO:0002300","count":5},{"id":"GO:0003093","count":5}]},{"hash":"1264082656294046024","title":"Neuronal Temperature and Pain Signaling","description":"The top GO terms cluster around neuronal excitability and thermosensation, including regulation of membrane potential, sensory perception of pain, and cellular response to temperature stimuli, plus related terms like diet-induced thermogenesis. Although there are some kidney/blood pressure related terms in the list, the strongest and most coherent theme across the majority of terms points to neuronal temperature sensing and pain signaling functions, suggesting the proteins may be involved in excitability and thermosensory pathways.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0018298","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0071502","count":5}]},{"hash":"493199847611361914","title":"CNS Myelin Maintenance and Neuronal Signaling","description":"The top GO terms are strongly centered on the nervous system: central nervous system myelin maintenance, spinal cord patterning, and reelin-mediated signaling, pointing to neuronal development and myelin-related processes. Some terms involve lipid and membrane metabolism (unsaturated fatty acid biosynthesis, ergosterol/sphingolipid-related processes) which can support myelin membrane composition, providing a plausible link to CNS structure and signaling. A few terms (nitrate assimilation, nitric oxide biosynthesis) are less CNS-specific but can reflect broader neural signaling contexts. Overall, the cluster appears to reflect CNS development and myelin-associated signaling with lipid metabolism as supporting context.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032286","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0006636","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0006809","count":2}]},{"hash":"1050667725548155705","title":"Unknown","description":"The Top Terms show both mitochondrial energy metabolism (mitochondrial respiratory chain complex II assembly; NADH to ubiquinone) and unrelated processes like wax and O-antigen biosynthesis, transcription regulation, and tissue development. Because there is no clear shared function or interaction pattern among these terms, the cluster cannot be meaningfully labeled with a single biological role.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034553","count":1},{"id":"GO:0006120","count":1},{"id":"GO:0009243","count":1},{"id":"GO:0010025","count":1},{"id":"GO:0006351","count":1}]},{"hash":"704940237192589094","title":"Mitochondrial lipid biosynthesis and remodeling","description":"The top GO terms cluster around lipid production and remodeling (ether lipid, phosphatidylcholine, cardiolipin, triglyceride, platelet activating factor) and a mitochondrial energy process (mitochondrial ATP synthesis coupled electron transport), suggesting a cohesive theme of lipid metabolism linked to mitochondrial function. Some terms are peripheral, but the lipid/mitochondrial theme is dominant.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008611","count":2},{"id":"GO:0010143","count":2},{"id":"GO:0002071","count":2},{"id":"GO:2001246","count":2},{"id":"GO:0019432","count":2}]},{"hash":"2072664295509941566","title":"Glycolysis and central carbon metabolism","description":"This cluster is dominated by glycolysis, pyruvate and malate metabolism, and NADP-related redox processes, plus cellular oxidant detoxification. Together they point to proteins involved in energy production (glycolysis and related pathways) and redox balance, i.e., central carbon metabolism with oxidative stress management. A few terms (dopamine metabolism regulation, ethanol response) are secondary stress/metabolic associations but don\u2019t negate the core theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0055114","count":2},{"id":"GO:1902031","count":1},{"id":"GO:0051262","count":1},{"id":"GO:0006108","count":1}]},{"hash":"16538439772660813","title":"Spliceosome-Driven mRNA Splicing and Export","description":"This cluster is dominated by GO terms tied to spliceosome-mediated mRNA splicing (cis, alternative, and regulatory) and mRNA export, with a few terms related to translation. The strong co-occurrence of splicing-related terms suggests the proteins act together in RNA processing via the spliceosome.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048025","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0075525","count":2},{"id":"GO:0001825","count":2}]},{"hash":"1721317731466216966","title":"Unknown","description":"The top terms span very diverse biological processes, including neuronal development, viral processes, cell cycle regulation and DNA repair, immune signaling, protein ubiquitination, peroxisome import, peptide transport, and telomere maintenance. There isn\u2019t a clear, single theme tying these functions together, suggesting this cluster doesn\u2019t reflect a cohesive biological module.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0010976","count":5},{"id":"GO:0016032","count":5},{"id":"GO:0000086","count":5},{"id":"GO:0042275","count":5},{"id":"GO:0035666","count":5}]},{"hash":"1009476692144743653","title":"Muscle and vascular development via PI3K/AKT signaling","description":"The cluster shows a clear emphasis on muscle biology (skeletal muscle fiber development, myoblast proliferation) and vascular biology (endothelial development, endothelial cell migration, angiogenesis in wound healing). The inclusion of positive regulation of PI3K/AKT signaling aligns with growth and survival pathways underpinning both muscle and endothelial cells, supporting a cohesive theme. Some terms like xenobiotic response and UV protection appear peripheral to this core theme. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009410","count":2},{"id":"GO:0046835","count":2},{"id":"GO:0048741","count":1},{"id":"GO:0060055","count":1},{"id":"GO:0033599","count":1}]},{"hash":"1142759558266819123","title":"Macrophage activation and cytoskeletal remodeling","description":"The GO terms point to macrophage- and myeloid-cell\u2013specific processes, including immunological synapse formation, podosome assembly, and positive regulation of chemokine production, all of which involve GTPase-driven cytoskeletal changes and membrane trafficking. This suggests a cohesive theme of macrophage signaling, adhesion, and cytoskeleton remodeling.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0001771","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0071642","count":2},{"id":"GO:0071803","count":2}]},{"hash":"1732341962041660932","title":"Innate Immune Response and Cytokine Production","description":"The top terms are dominated by innate immune response and cytokine production, suggesting the cluster centers on innate immunity. Several other terms (nuclear import/export, mRNA export, light absorption) seem unrelated to immune function and may reflect annotation noise or incidental associations. With a small cluster and mixed signals, this label captures the strongest theme but has only moderate confidence.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002374","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006606","count":1},{"id":"GO:0016037","count":1},{"id":"GO:0000056","count":1}]},{"hash":"430904551046623703","title":"Skin development and epidermal differentiation","description":"The top GO terms are dominated by keratinocyte and epidermal development (keratinocyte development, skin development, regulation of epidermal cell division), indicating a core role in epidermal differentiation. Additional terms like Golgi reassembly and signals such as insulin/glucocorticoid pathways and p53-related responses reflect related cellular processes that can accompany differentiation but do not override the epidermal focus.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003334","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0010482","count":2},{"id":"GO:0090168","count":2},{"id":"GO:0001764","count":2}]},{"hash":"745396319546477037","title":"Protein folding stress response","description":"The GO terms cluster around protein folding and misfolding processes (amyloid fibril formation; chaperone-mediated folding; folding-related maturation), indicating a proteostasis focus. Additional terms hint at stress signaling (calcium release from the sarcoplasmic reticulum; TGF-beta signaling) and metabolic stress responses, suggesting a broader stress-response context anchored by protein folding. ","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990000","count":2},{"id":"GO:0035634","count":2},{"id":"GO:0061077","count":1},{"id":"GO:0048680","count":1},{"id":"GO:0061179","count":1}]},{"hash":"1793858250775344381","title":"Unknown","description":"The GO terms span xenobiotic degradation, metal and calcium transport, ion homeostasis, ATP-related cellular responses, amino acid biosynthesis, P450 pathways, protein dephosphorylation, and lipopolysaccharide core biosynthesis, with no single cohesive function emerging across all proteins. This makes it unclear how the cluster functions as a unit.","confidence":"","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046196","count":3},{"id":"GO:0070574","count":3},{"id":"GO:0006874","count":3},{"id":"GO:0071318","count":3},{"id":"GO:0006564","count":3}]},{"hash":"372711994483229039","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006414","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0032232","count":1}]},{"hash":"420372064586361008","title":"Unknown","description":"The GO terms are highly diverse across species and processes (lung development, plant root growth and hormone signaling, glucocorticoid signaling, neuroblast polarity, hypoxia response, telomerase assembly) with no evident shared function or interaction (no edges). This lacks a cohesive theme to name beyond Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060430","count":1},{"id":"GO:0048642","count":1},{"id":"GO:0010449","count":1},{"id":"GO:0080037","count":1},{"id":"GO:2000012","count":1}]},{"hash":"1403437438146076424","title":"Neuronal Exocytosis and Development Signaling","description":"The cluster centers on neuronal signaling and development: calcium-dependent exocytosis relates to neurotransmitter release at synapses, reflected by excitatory postsynaptic potentials; terms for nervous system and hippocampus development; ephrin receptor signaling and Wnt signaling are pivotal for synapse formation and neural differentiation. Some outliers like pseudohyphal growth appear noise, but the dominant themes point to neuronal synaptic signaling and development.","confidence":"High","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045956","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0048013","count":4},{"id":"GO:0000186","count":4},{"id":"GO:0090263","count":4}]},{"hash":"1089109949543081062","title":"Spliceosome-Mediated RNA Processing","description":"The top terms are dominated by spliceosome- and RNA processing-related processes (negative/positive regulation of mRNA splicing via spliceosome, alternative mRNA splicing, mRNA export and stabilization, processome assembly) with additional hints of translation initiation complex formation and ribosome biogenesis, suggesting the cluster represents RNA metabolism centered on splicing and early translation steps.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":5},{"id":"GO:0048025","count":5},{"id":"GO:0001825","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0048026","count":5}]},{"hash":"1912297899300975656","title":"Ubiquitin-Dependent Protein Turnover and Apoptosis Regulation","description":"This cluster is dominated by GO terms tied to ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process, autoubiquitination) and signaling pathways that govern cell fate (regulation of JNK cascade, regulation of apoptotic process). Additional terms related to chromatin dynamics (histone catabolic process) and dosage compensation suggest broader roles for ubiquitin in regulating transcriptional and chromatin states. Overall, the proteins likely function together in ubiquitin-dependent protein turnover that modulates stress signaling and apoptosis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046328","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0042981","count":3},{"id":"GO:0009048","count":3}]},{"hash":"603433295959938166","title":"X Chromosome Inactivation and Epigenetic Regulation","description":"The top GO terms are dominated by dosage compensation and random X inactivation (dosage compensation by inactivation of X chromosome; random inactivation of X chromosome), with supporting links to histone turnover and broader epigenetic regulation (histone catabolic process, regulation of apoptotic process). A few terms reference seemingly unrelated pathways, but the core theme points to X-linked epigenetic control and dosage compensation. This suggests a cluster centered on X chromosome inactivation and associated epigenetic regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900095","count":2},{"id":"GO:0042981","count":2},{"id":"GO:0009048","count":2},{"id":"GO:0016558","count":2},{"id":"GO:0036205","count":2}]},{"hash":"350071352563898194","title":"Ubiquitin-Regulated Proteolysis and Immune Signaling","description":"The top GO terms cluster around ubiquitin machinery (ubiquitin ligase activity, SCF-dependent proteasomal degradation, and deubiquitination) indicating regulation of protein turnover. Additional terms point to immune-related processes (antigen processing/presentation and C-type lectin receptor signaling), with viral process and Wnt signaling likely reflecting cross-talk through ubiquitination. Overall, this cluster appears to connect ubiquitin-mediated proteolysis with immune signaling pathways.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051437","count":4},{"id":"GO:0016032","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0002223","count":4},{"id":"GO:0010363","count":4}]},{"hash":"283431204154990260","title":"Neural development and cell adhesion","description":"The top GO terms concentrate on nervous system development, synapse assembly, and both homophilic and heterophilic cell-cell adhesion, pointing to roles in neural connectivity and tissue organization during development. While there are also terms related to organ induction and ossification, the strongest recurring theme is neural development driven by cell adhesion.","confidence":"Medium","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0051965","count":2}]},{"hash":"998939138215870006","title":"Unknown","description":"The GO terms span innate immune response, transcription, ribosome biogenesis, developmental processes (skeletal, neural tube closure), microtubule localization, and cell cycle, with no clear single function linking the proteins. The terms are too heterogeneous to derive a cohesive cluster label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0035372","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1518902266346695504","title":"Choline and phospholipid metabolism","description":"Top terms indicate a strong focus on ethanolamine/choline processing and phospholipid biosynthesis, including ethanolamine metabolic process, phosphatidylethanolamine biosynthetic process, choline metabolic process, and the CDP-choline pathway. This suggests the proteins function together in glycerophospholipid synthesis; some other terms (e.g., response to antibiotic) are less specific but represent broader cellular responses. Overall, the cluster appears to reflect choline and phospholipid metabolism.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":5},{"id":"GO:0016310","count":5},{"id":"GO:0019509","count":5},{"id":"GO:0009088","count":5},{"id":"GO:0019284","count":5}]},{"hash":"270596752595545176","title":"ER-Golgi Vesicle Trafficking and Growth","description":"This cluster is dominated by GO terms for ER-to-Golgi and COPII vesicle budding, with additional growth and developmental terms. The repeated emphasis on vesicle trafficking between the ER and Golgi (anterograde and retrograde) suggests a shared function in the secretory pathway, which can influence cell growth, division, and brain development signals in multicellular contexts. Thus the name reflects the core trafficking process plus associated growth-related roles.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0090114","count":4},{"id":"GO:0051301","count":4}]},{"hash":"2028970777332032641","title":"Ubiquitin-mediated degradation and growth regulation","description":"The top GO terms center on ubiquitin-dependent protein catabolic processes and ERAD, including various ubiquitin linkages on histones and other proteins, which points to a core function in tagging proteins for degradation. Several terms relate to apoptosis regulation and organ growth, suggesting involvement in ubiquitin-mediated signaling that governs cell fate and development. A peroxisome matrix import term appears peripheral but may reflect broader protein turnover pathways. Overall, the cluster seems to capture ubiquitin-linked regulation of protein turnover and growth-related signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0070535","count":3},{"id":"GO:1903721","count":3},{"id":"GO:0046621","count":3}]},{"hash":"1773808098265382629","title":"Vesicle trafficking and exosome secretion","description":"The most strongly represented terms cluster around vesicle trafficking and secretion: Golgi vesicle budding, exosomal secretion, and regulation of synaptic vesicle exocytosis. Although some terms touch on development (dendrite growth, muscle satellite cell migration) and other processes, the common thread is vesicle formation and release, suggesting a role in trafficking or secretion pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048194","count":3},{"id":"GO:1902766","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0051291","count":3},{"id":"GO:0016358","count":3}]},{"hash":"1645883595136678770","title":"DNA damage response and genome maintenance","description":"This cluster centers on DNA metabolism and genome integrity: DNA replication, DNA-templated transcription, and nucleotide-excision repair terms appear prominently, with related processes like apoptosis and proteasome assembly indicating stress response and protein turnover tied to damage signaling. Some terms (innate immune response, chlorophyll biosynthesis) may reflect annotation noise or cross-species annotations. Overall, the cluster is best described as DNA damage response and genome maintenance.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0043248","count":1}]},{"hash":"1587604884648718494","title":"ER-Golgi trafficking and ER stress response","description":"The dominant GO terms indicate transport between the endoplasmic reticulum and Golgi, including ER to Golgi vesicle-mediated transport and ER stress response, plus Golgi vesicle budding, pointing to a secretory pathway focus. A few terms like dendrite development or keratinization are less central to this cluster, so the overall theme centers on ER-Golgi trafficking and related stress responses.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016358","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0034976","count":2},{"id":"GO:0006888","count":2},{"id":"GO:1903206","count":2}]},{"hash":"56259321350389320","title":"Neuronal synaptic vesicle release and SNARE assembly","description":"This cluster is dominated by terms tied to presynaptic neurotransmitter release: vesicle priming, fusion to the presynaptic membrane, SNARE complex assembly, and calcium-regulated exocytosis, alongside related ion transport. The presence of mitochondrial translation and Complex IV assembly terms suggests energy/metabolic support for synaptic activity, while a sleep term may reflect broader neural regulation. Overall, the data point to a cohesive theme of neuronal vesicle cycling and SNARE-mediated release.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032973","count":1},{"id":"GO:1990034","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0070131","count":1},{"id":"GO:0048791","count":1}]},{"hash":"2228693468417317676","title":"Embryonic development and tissue morphogenesis","description":"The GO terms cluster around embryonic tissue differentiation and organ morphogenesis\u2014placenta, cartilage, pancreatic/endocrine development, heart EMT in endocardial cushion formation, trophoblast differentiation, and left-right patterning\u2014reflecting a common theme of embryogenesis and tissue formation. Obsolete epigenetic terms appear as noise and do not alter the main signal.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0003323","count":3}]},{"hash":"831200634368215662","title":"DNA replication and genome maintenance","description":"Most terms point to core DNA replication, recombination, and genome maintenance (DNA replication, DNA recombination, telomere maintenance, mitochondrial DNA repair, mitochondrial genome maintenance, RNA primer removal in mitotic replication). A couple of terms refer to photosynthesis-related processes, which may be annotation noise or multi-functional proteins, but the dominant signal is DNA maintenance. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030494","count":1},{"id":"GO:0051974","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0015979","count":1},{"id":"GO:0000723","count":1}]},{"hash":"868004490443941502","title":"Vacuolar Autophagy and Cvt Pathway Cluster","description":"The top GO terms point strongly to autophagy-related processes, including macroautophagy, the Cvt (cytoplasm-to-vacuole targeting) pathway, and piecemeal microautophagy of the nucleus, suggesting a shared function in autophagic degradation and vacuolar trafficking. Other terms like tRNA wobble thiolation and various biosynthetic processes likely reflect broader cellular maintenance but do not offset the dominant autophagy signal. Therefore, the name captures the central theme of autophagy/vacuolar targeting for this cluster.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032447","count":3},{"id":"GO:0002143","count":3},{"id":"GO:0061504","count":2},{"id":"GO:0006777","count":2},{"id":"GO:0050832","count":2}]},{"hash":"1203241256474064173","title":"Broad Embryonic Development","description":"The top GO terms are dominated by development across multiple tissues (craniofacial, neural/brain regions, peripheral nervous system, pancreas, bronchioles), indicating a general developmental role rather than a specific pathway. This justifies a broad embryonic/organ development label.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0021920","count":2},{"id":"GO:0003322","count":2},{"id":"GO:0021905","count":2},{"id":"GO:0060435","count":2}]},{"hash":"189439277966631685","title":"Glycan biosynthesis and mammary gland development","description":"GO terms cluster around glycan biosynthesis (glycosphingolipids, keratan sulfate proteoglycans, lactose) and mammary gland development, plus related reproductive processes. The common theme is glycosylation and glycan-containing molecules produced in mammary tissue, aligning with lactation biology, with some terms touching gamete recognition. This supports labeling as a glycan- and mammary-development\u2013centered cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006688","count":3},{"id":"GO:0060058","count":2},{"id":"GO:0007339","count":2},{"id":"GO:0007341","count":2},{"id":"GO:0030879","count":2}]},{"hash":"144645974751615602","title":"Ubiquitin-Proteasome System Regulation","description":"The top GO terms point to deubiquitination and ubiquitin-dependent proteasomal degradation (e.g., protein deubiquitination and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process), suggesting the cluster centers on ubiquitin cycling and proteasome-mediated turnover; other terms appear ancillary or broader, not changing the main theme.","confidence":"Medium","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":3},{"id":"GO:0014070","count":3},{"id":"GO:0051437","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0090263","count":2}]},{"hash":"1646765780861262055","title":"Autophagy and vacuolar trafficking","description":"This cluster is strongly tied to autophagy: macroautophagy, the cytoplasm-to-vacuole targeting (Cvt) pathway, and piecemeal microautophagy of the nucleus are all autophagic degradation routes that converge on the vacuole/lysosome. While other terms such as thiamine/mo-molybdopterin biosynthesis and some immune-related terms appear, the dominant shared function among the top terms is autophagic vesicle formation and vacuolar degradation, supporting a label around autophagy and vacuolar trafficking.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0039536","count":2},{"id":"GO:0061504","count":2},{"id":"GO:0006777","count":2},{"id":"GO:0050832","count":2}]},{"hash":"2195208293640800157","title":"Embryonic development and morphogenesis","description":"The top GO terms are dominated by developmental processes: placenta development, cartilage morphogenesis, endocrine system development, EMT in heart formation, pancreatic cell development, trophoblast differentiation, and left-right patterning. This pattern suggests the proteins are broadly involved in embryonic development and tissue morphogenesis rather than a single specific pathway. Minority terms related to RNA polymerase II regulation and splicing are less representative of the main theme. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0003323","count":5}]},{"hash":"458856893882914555","title":"Glycan and lipid metabolism","description":"The top GO terms cluster around carbohydrate catabolic/metabolic processes (keratan sulfate proteoglycan, galactose, polysaccharides) and glycosphingolipid/lipid biosynthetic metabolism (glycosphingolipids, phosphatidylethanolamine, platelet activating factor), suggesting a group of proteins involved in glycan turnover and lipid metabolic pathways rather than direct signaling or cell-cycle control. The absence of interactions corroborates a shared metabolic theme rather than a physical protein complex.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042340","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0006687","count":1},{"id":"GO:0019388","count":1},{"id":"GO:0006012","count":1}]},{"hash":"508942046634946913","title":"Plant Hormone Metabolism and Stress Response","description":"The top GO terms are largely plant-focused, including gibberellin biosynthesis/catabolism, fruit ripening, and salicylic acid catabolism, along with stress-related processes like hypoxia response and hydrogen peroxide\u2013mediated programmed cell death. This suggests a cohesive theme around plant hormone signaling and stress responses, despite a few outlier terms (e.g., poly-hydroxybutyrate and penicillin biosynthesis) that may reflect cross-annotation. Overall, a plant hormone/stress cluster is the most representative interpretation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0001666","count":2},{"id":"GO:0009086","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0045487","count":1}]},{"hash":"644341340175899605","title":"Angiogenesis and vascular development signaling","description":"The top GO terms cluster around blood vessel formation and endothelial signaling\u2014VEGF receptor signaling, angiogenesis, and positive regulation of angiogenesis\u2014along with supporting terms in skeletal development, Wnt pathway regulation, prostaglandin response, IL-1 signaling, and apoptotic regulation. This coherence suggests the proteins are involved in vascular development and angiogenic signaling rather than unrelated processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048010","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0045766","count":3}]},{"hash":"2012571701508037497","title":"Chromatin organization and nucleosome assembly","description":"The cluster centers on chromatin biology, with terms for heterochromatin organization, nucleosome assembly/positioning, and localization to chromatin, plus histone modification (H3K4/H3K27) themes. Obsolete terms still reflect histone-centric regulation and chromatin dynamics, suggesting these proteins function together in chromatin structure and epigenetic regulation, with a possible ancillary link to DNA repair via chromatin remodeling.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":5},{"id":"GO:0070828","count":5},{"id":"GO:0071169","count":5},{"id":"GO:0080182","count":5},{"id":"GO:0016584","count":5}]},{"hash":"708401298719703994","title":"MAPK signaling regulation and tissue development","description":"The top GO terms center on positive regulation of the ERK1/ERK2 cascade, pointing to MAPK pathway control, and two tissue-development terms (lung connective tissue development and nipple morphogenesis), suggesting a developmental signaling theme. Additional terms reference GPCR/cAMP signaling, renin-angiotensin physiology, and immune differentiation, indicating broader signaling regulation affecting development and organ function.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0043950","count":1},{"id":"GO:0035625","count":1}]},{"hash":"937565063553393040","title":"Tissue morphogenesis signaling","description":"This cluster centers on developmental processes across multiple tissues, with GO terms highlighting photoreceptor morphogenesis, Schwann cell development, and ventricular cardiac muscle morphogenesis, as well as the calcineurin-NFAT signaling cascade that influences gene expression during development. While a few terms touch broader cellular processes (e.g., chromatin binding regulation, membrane tubulation), the shared theme is signaling guiding tissue morphogenesis.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035191","count":1},{"id":"GO:0043950","count":1},{"id":"GO:1903525","count":1},{"id":"GO:0033173","count":1},{"id":"GO:0008594","count":1}]},{"hash":"1079590410313652304","title":"Lymphoid development and NF-kappaB signaling","description":"The most represented GO terms cluster around immune system development (spleen and lymph node development) and regulation of the NF-kappaB pathway, suggesting these proteins collectively relate to lymphoid development and NF-\u03baB\u2013mediated immune signaling. Some terms are older/obsolete, but the core themes point to immune development and NF-\u03baB regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048536","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0090086","count":2},{"id":"GO:1901536","count":2}]},{"hash":"784882811697771179","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071042","count":1},{"id":"GO:0071039","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0016973","count":1},{"id":"GO:0033621","count":1}]},{"hash":"1689139063690950947","title":"Embryonic Development and Morphogenesis","description":"Top GO terms indicate embryonic development and tissue morphogenesis (placenta, cartilage, endocrine system), EMT in heart development, and lineage-specific differentiation (pancreatic cells, left-right patterning). This points to a cohesive theme of embryogenesis and organogenesis, with some broader developmental signaling contexts. Confidence: High","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0003323","count":2}]},{"hash":"1910426694104332980","title":"Mitochondrial energy metabolism and Fe-S cluster assembly","description":"The terms converge on mitochondria: calcium import/handling, mitochondrial electron transport (succinate dehydrogenase), iron incorporation into metallo-sulfur clusters and iron homeostasis, and respiratory complex assembly. Some terms reflect metabolism and signaling linked to mitochondrial function (insulin secretion, proprioception, growth), but the core theme points to mitochondrial energy metabolism and Fe-S cluster biogenesis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051561","count":1},{"id":"GO:0032024","count":1},{"id":"GO:0035786","count":1},{"id":"GO:0036444","count":1},{"id":"GO:0018283","count":1}]},{"hash":"1380502486714787315","title":"Purine Nucleotide Metabolism","description":"The cluster is enriched for GO terms tied to nucleotide phosphorylation, salvage, and interconversion (AMP salvage, ADP/CDP phosphorylation, nucleoside monophosphate phosphorylation, GTP metabolism, purine ribonucleotide interconversion, etc.), indicating a shared role in purine nucleotide biosynthesis and turnover. A couple of development terms (liver and brain development) appear, but the dominant signal is nucleotide metabolism.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046939","count":3},{"id":"GO:0046041","count":3},{"id":"GO:0044209","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0046705","count":3}]},{"hash":"2069655538176696978","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034476","count":2},{"id":"GO:0006268","count":2},{"id":"GO:0070870","count":2},{"id":"GO:0000390","count":2},{"id":"GO:0006363","count":2}]},{"hash":"2296714998027905474","title":"Unknown","description":"The GO terms span chromatin-related processes and germline/fertilization aspects, development and differentiation, immune defense, RNA decay, and proteolytic activation, with no single cohesive function tying all proteins together. This lack of a common theme makes a specific, representative label unlikely.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0007549","count":1},{"id":"GO:2000973","count":1},{"id":"GO:1904693","count":1}]},{"hash":"1113115073598589349","title":"Inflammatory and oxidative stress response","description":"The strongest GO terms center on cellular responses to TNF, IL-1, hydrogen peroxide, and ethanol, indicating a stress- and inflammation-related module. Additional hints of TOR signaling and GTPase regulation exist but are secondary, so the core theme is inflammatory/oxidative stress response.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071356","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0071230","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1341151471907120813","title":"Transmembrane nutrient and ion transport","description":"Most terms describe transport across the plasma membrane for various substrates (myo-inositol, biotin, D-glucose, pantothenate) and sodium ion export, indicating a cluster of membrane transport proteins handling small molecules. One GO term (acetylcholine biosynthetic process) is an outlier and does not fit the transport theme, but the overall functional signal points to membrane transport.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008292","count":1},{"id":"GO:0071436","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0015878","count":1},{"id":"GO:1904659","count":1}]},{"hash":"1817724498038936680","title":"Unknown","description":"The top terms are a broad mix (transcription regulation, Wnt signaling, necroptosis, inflammatory response, ubiquitination, insulin secretion, and various cell-cycle/localization terms) with no clear, single functional theme connecting the proteins, and the network has no edges. This makes a specific, representative label unlikely.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0070266","count":1},{"id":"GO:0061178","count":1},{"id":"GO:0031503","count":1},{"id":"GO:0045035","count":1}]},{"hash":"1261368632276291150","title":"Renin\u2013Angiotensin\u2013Mediated Blood Pressure Regulation","description":"The top GO terms point to cardiovascular and renal control, notably regulation of systemic arterial blood pressure by the renin\u2013angiotensin system and positive regulation of renin secretion, along with related renal functions (glomerular filtration) and hormone secretion. While some terms are less directly related (e.g., operant conditioning, immune cell differentiation), the strongest signals describe hormonal and renal mechanisms governing blood pressure and fluid balance.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":4},{"id":"GO:0035625","count":4},{"id":"GO:0001991","count":4},{"id":"GO:0002300","count":4},{"id":"GO:0003093","count":4}]},{"hash":"68803270757909457","title":"Pain and Thermal Sensory Response","description":"Based on the top GO terms, the cluster is dominated by sensory processes related to pain perception and temperature-related responses (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis). A few terms concern unrelated processes (renal regulation, T cell differentiation, operant conditioning) suggesting some noise, but the core signal points to nociception and thermosensation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0043950","count":2},{"id":"GO:0035625","count":2}]},{"hash":"770714910972038189","title":"Unknown","description":"The proteins appear to cover two distinct themes: RNA processing regulation (alternative splicing and mRNA stability in stress) and diverse amino acid/ neurotransmitter transport across membranes. There isn\u2019t a single coherent function tying all four proteins together, so a concise, representative label cannot be determined.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0051938","count":1},{"id":"GO:0009449","count":1},{"id":"GO:0070779","count":1}]},{"hash":"793890735888396864","title":"Bacterial cell wall biosynthesis","description":"This cluster\u2019s top GO terms are dominated by peptidoglycan and lipopolysaccharide biosynthesis, GDP-mannose\u2013linked glycan formation, and cell wall organization/regulation of cell shape, pointing to proteins involved in bacterial cell envelope synthesis and maintenance. Some terms (e.g., fungal-type cell wall biogenesis) are broader or cross-kingdom annotations, but the prevailing theme is cell wall biosynthesis and related glycan pathways, which justifies a label focused on the bacterial cell wall. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008360","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0009252","count":2},{"id":"GO:0009298","count":2},{"id":"GO:0071555","count":2}]},{"hash":"1398447851312552125","title":"Developmental Morphogenesis and Signaling","description":"The top GO terms point to diverse developmental processes across tissues\u2014axon guidance, myelination, lens fiber differentiation, organ induction, skeletal development, and BMP signaling\u2014indicating a cluster focused on developmental morphogenesis and signaling pathways rather than a single tissue or pathway. Although some terms are obsolete, the common theme is tissue formation and differentiation during development.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":3},{"id":"GO:0010693","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0030513","count":3}]},{"hash":"1204501203109369000","title":"Epithelial polarity and junction assembly","description":"The top GO terms point to polarized cell architecture (basolateral membrane localization, tight junction and microvillus assembly, barrier establishment) and epithelial/endothelial organization, which together suggest proteins involved in establishing and maintaining cell polarity and junctions during development. Some terms related to neural development (neural plate elongation, cochlea morphogenesis) reflect processes that also rely on polarized cell structures, supporting a unifying theme of junctional/polarity machinery across tissues.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903361","count":1},{"id":"GO:0022007","count":1},{"id":"GO:0090557","count":1},{"id":"GO:0030033","count":1},{"id":"GO:0070830","count":1}]},{"hash":"1779379483539024955","title":"Mitotic cell cycle regulation","description":"The two top terms point to G1/S transition and regulation of the cell cycle, with supporting terms about mitotic spindle pole separation and re-entry into the mitotic cycle, indicating a cohesive theme around mitosis control. A few unrelated terms appear (transcription, viral transcription, stomatal opening) likely reflecting annotation noise, but they do not override the dominant cell cycle signal.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000082","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0060749","count":1},{"id":"GO:0010696","count":1},{"id":"GO:1905866","count":1}]},{"hash":"1713215205689616017","title":"Ubiquitin-Proteasome Regulation of Mitosis","description":"The cluster is centered on ubiquitin-mediated protein degradation, with terms for K11-linked ubiquitination, SCF- and APC/C-dependent proteasomal catabolism, and mitotic cell cycle control, plus neddylation as a regulator of cullin ligases. This points to a coherent theme of ubiquitin-proteasome\u2013driven regulation of mitosis and cell division, with ancillary ties to DNA repair and stress responses.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070979","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0070911","count":3},{"id":"GO:0016032","count":3}]},{"hash":"1838801559983384088","title":"Neural development and dopamine metabolism","description":"The presence of GO terms for neuron projection development, neural precursor cell proliferation, and dopamine metabolic regulation points to neural development as the primary theme. Related terms like xenobiotic and ethanol response are less central, and other metabolic terms may reflect background processes. Thus label captures the core neural signaling/differentiation function.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":1},{"id":"GO:0046168","count":1},{"id":"GO:2000179","count":1},{"id":"GO:0045964","count":1},{"id":"GO:0060992","count":1}]},{"hash":"1410466260542122665","title":"Neural development and brain regionalization","description":"This cluster's top GO terms center on brain development, regional specification, and neural differentiation (forebrain, subpallium, peripheral nervous system neurons) with regulation of glial differentiation. A few terms unrelated to neural tissue appear, but the dominant pattern is neural development and brain region formation.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021920","count":2},{"id":"GO:0003322","count":2},{"id":"GO:0021905","count":2},{"id":"GO:0060435","count":2},{"id":"GO:1902723","count":2}]},{"hash":"311702397598823343","title":"Bacterial exopolysaccharide biosynthesis","description":"The cluster is characterized by GO terms related to polysaccharide production and modification in bacteria, including alginic acid biosynthetic process, UDP-glucuronate biosynthetic process, and enterobacterial common antigen biosynthesis, as well as alginate biosynthesis. These strongly point to bacterial exopolysaccharide synthesis and cell-surface polysaccharide assembly. A few terms (gastrulation, vulval development) appear unrelated and may reflect cross-species annotations or noise, but the core signal centers on polysaccharide biosynthesis and metabolism.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001702","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006813","count":1},{"id":"GO:0046168","count":1},{"id":"GO:0040025","count":1}]},{"hash":"1280471520299439255","title":"Unknown","description":"The GO terms span mitochondrial tRNA modification, lipoylation, proteolysis, telomere maintenance via recombination, and reproductive development (meiotic cell cycle, spermatogenesis, differentiation), with no single cohesive function tying the cluster together. Given the diversity and the lack of edges, a confident, specific label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072670","count":1},{"id":"GO:0046944","count":1},{"id":"GO:0000722","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0051321","count":1}]},{"hash":"922079364397320214","title":"Immune Activation and Chemokine Signaling","description":"The top GO terms are dominated by immune-related processes: positive regulation of NK cell cytokine production, CCR7 signaling, chemokine production, and defense responses to bacteria and peptidoglycan. These point to a cohesive theme of immune cell signaling and host defense, suggesting this cluster represents immune activation. Some terms like spermatid development, lens morphogenesis, and AV node activity may reflect annotation noise or multifunctional proteins, but the core signal is immune-related. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002729","count":2},{"id":"GO:1903082","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0071224","count":2},{"id":"GO:0043031","count":2}]},{"hash":"922628020548717872","title":"Dopamine receptor trafficking and recycling","description":"The top terms strongly suggest a module centered on dopamine GPCR signaling coupled with receptor endocytosis and recycling (endosome-to-postsynaptic membrane transport, clathrin coat assembly, and positive regulation of receptor recycling). While a few unrelated terms appear (bone mineralization, interferon responses), the core cluster aligns with synaptic receptor turnover and trafficking of dopamine receptors. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098887","count":1},{"id":"GO:0045807","count":1},{"id":"GO:0007212","count":1},{"id":"GO:0048268","count":1},{"id":"GO:0001921","count":1}]},{"hash":"1846764455775910822","title":"Embryonic morphogenesis and organ development","description":"The proteins are associated with multiple embryonic developmental processes across various tissues (heart tube, gut, nail, neural tracts, hypothalamus), plus signaling and regulatory pathways, suggesting a cohesive theme of developmental morphogenesis and organogenesis rather than a specific single function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048613","count":2},{"id":"GO:0021855","count":2},{"id":"GO:0007495","count":2},{"id":"GO:1901250","count":2},{"id":"GO:0008286","count":2}]},{"hash":"734949602601207534","title":"Actin Cytoskeleton Remodeling in Immune and Muscle Cells","description":"The top GO terms cluster around actin filament polymerization, ruffle assembly, and signaling events (protein phosphorylation), indicating actin-driven cytoskeleton remodeling that governs cell shape and movement. The presence of skeletal muscle fiber development and budding cell apical bud growth suggests broader morphogenesis roles, while terms related to lymphocyte migration and T cell antigen processing point to immune cell motility and signaling. Together, these terms support a theme of actin-based cytoskeletal dynamics coordinating motility and development in immune and muscle contexts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":2},{"id":"GO:0001402","count":1},{"id":"GO:0048741","count":1},{"id":"GO:0007118","count":1},{"id":"GO:1900028","count":1}]},{"hash":"1373960991021765790","title":"Endocytosis and Membrane Signaling Regulation","description":"The top GO terms cluster around endocytosis, phospholipid homeostasis, and regulation of GTPase activity, with an insulin receptor signaling term also pointing to membrane-associated signaling control. While some terms (visual perception, retinoic acid response) touch on development, the strongest signal ties to membrane trafficking and signaling regulation rather than a single metabolic or developmental pathway.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:0055091","count":2},{"id":"GO:0010628","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0034260","count":2}]},{"hash":"353419813149119637","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072300","count":2},{"id":"GO:0086073","count":2},{"id":"GO:0003273","count":2},{"id":"GO:0060243","count":2},{"id":"GO:0070445","count":2}]},{"hash":"1362874719998396849","title":"Developmental patterning and morphogenesis","description":"The top GO terms cluster around developmental processes, including wing margin morphogenesis, segment polarity, midbrain development, and BMP signaling regulation, which all relate to patterning and morphogenesis. Additional terms on heparan proteoglycan biosynthesis and protein sulfation support extracellular signaling and matrix roles in development. Taken together, the proteins appear to participate in developmental patterning and tissue morphogenesis rather than a single narrowly defined function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048488","count":1},{"id":"GO:0002002","count":1},{"id":"GO:0006477","count":1},{"id":"GO:0007427","count":1},{"id":"GO:0007367","count":1}]},{"hash":"448790179930173795","title":"Ubiquitin-Dependent Protein Degradation","description":"Based on the top GO terms, the cluster is enriched for ubiquitin-dependent protein catabolic processes, including ERAD and autoubiquitination, indicating a shared role in tagging and degrading proteins via ubiquitination. Some listed terms about apoptosis and immune signaling appear ancillary rather than core to the cluster\u2019s primary function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0042981","count":3},{"id":"GO:0009048","count":3}]},{"hash":"720370207574478814","title":"RNA Polymerase I/III Transcription Initiation","description":"Based on the GO terms, the cluster is dominated by transcription initiation activities of RNA polymerases I and III, including nucleolar rRNA transcription by Pol I and Pol III transcription initiation, as well as related initiation complex assembly and regulation. This indicates the proteins are involved in the transcription machinery rather than other processes. Some entries are obsolete or generic, but the strongest signal centers on Pol I/III\u2013driven transcription initiation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006919","count":2},{"id":"GO:0006413","count":1},{"id":"GO:0006383","count":1},{"id":"GO:0070893","count":1},{"id":"GO:0006352","count":1}]},{"hash":"248526189479082049","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030866","count":4},{"id":"GO:0090140","count":4},{"id":"GO:0006929","count":4},{"id":"GO:1904670","count":4},{"id":"GO:0071420","count":4}]},{"hash":"398840656131365499","title":"Tissue development and morphogenesis","description":"Most top GO terms point to developmental and morphogenetic processes across multiple tissues (nerve myelination, nail and craniofacial morphogenesis, axon regeneration at NMJ, heart development, mesoderm differentiation, tube development). This suggests a broad theme of tissue development rather than a single precise function. Some terms (viral process, ApoA-I signaling) may be peripheral or noisy annotations. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0032289","count":3},{"id":"GO:0035878","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0038027","count":3},{"id":"GO:0014814","count":3}]},{"hash":"375486213875199600","title":"Hepatic development and amino acid metabolism","description":"The GO terms point to liver-specific development (liver development, hepatocyte differentiation) and growth hormone response, paired with multiple amino acid biosynthesis/metabolic processes (arginine, citrulline, glutamine) and related pathways (carbamoyl phosphate, methylglyoxal, dihydrofolate). This pattern suggests the proteins are involved in hepatic development together with liver-focused amino acid metabolism and related biosynthetic activities.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":1},{"id":"GO:0060416","count":1},{"id":"GO:0006526","count":1},{"id":"GO:0070365","count":1},{"id":"GO:0070409","count":1}]},{"hash":"785258799974592436","title":"Chromatin maintenance and DNA repair","description":"This cluster's GO terms converge on heterochromatin maintenance/forming, histone modification, transcription regulation, and DNA damage repair, suggesting proteins collaborate in maintaining chromatin state and genome integrity.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902368","count":1},{"id":"GO:0032703","count":1},{"id":"GO:0046529","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0043981","count":1}]},{"hash":"1535820191515378608","title":"Rod photoreceptor cilium and outer segment development","description":"The GO terms show a strong emphasis on non-motile cilium assembly, protein localization to photoreceptor outer segments, and retinal rod cell development, suggesting a photoreceptor cilium/outer segment biology. Other terms like unfolded protein response or dsRNA response appear as peripheral signals rather than core themes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0021756","count":1},{"id":"GO:0003085","count":1},{"id":"GO:0071360","count":1}]},{"hash":"2076403809534381919","title":"Mesoderm development and muscle signaling","description":"The terms point to developmental programs in the mesoderm (mesoderm formation, stem cell differentiation) with links to muscle activity and proliferation signaling (cell cycle regulation, VEGF/PDGF pathways). Potassium transport and nitric oxide response can be tied to muscle tissue physiology and signaling, while transcriptional regulation and DNA replication reflect overarching developmental and proliferative processes. Together, they suggest a cluster centered on mesodermal development with muscle-related signaling and proliferation control.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006813","count":3},{"id":"GO:0000320","count":2},{"id":"GO:0014850","count":2},{"id":"GO:0006351","count":2},{"id":"GO:2000738","count":2}]},{"hash":"154230361431891046","title":"Unknown","description":"The top GO terms are highly diverse and loosely related, spanning membrane transport (proton and monoatomic cation transmembrane transport, manganese ion homeostasis), metabolism/response (stilbene catabolic process, response to glycoside), signaling regulation (positive regulation of peptidyl-serine phosphorylation; negative regulation of heart contraction; adrenergic receptor signaling), and development (cerebellar Purkinje cell differentiation; T-tubule organization). There is no clear, single biological theme or common function tying all four proteins together, and with no edges and only two annotations per term, assigning a coherent, specific label is not feasible.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046272","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0099132","count":2},{"id":"GO:0015991","count":2},{"id":"GO:1901205","count":2}]},{"hash":"2243782721939882607","title":"Eye morphogenesis transcriptional program","description":"The top GO terms are dominated by eye development and embryonic eye morphogenesis (camera-type eye development; embryonic eye morphogenesis), with a general transcription by RNA polymerase II term, suggesting these proteins are involved in transcriptional regulation during ocular morphogenesis, even in a small cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":4},{"id":"GO:0043010","count":3},{"id":"GO:0048048","count":3},{"id":"GO:0060441","count":3},{"id":"GO:0021920","count":2}]},{"hash":"860188437981120563","title":"Mitotic cell cycle checkpoints and proliferation control","description":"The top GO terms center on regulation of mitosis (negative regulation of ubiquitin-protein ligase activity in the mitotic cell cycle, mitotic G1 DNA damage checkpoint signaling, re-entry into the mitotic cell cycle) and restraint of cell proliferation, suggesting a cohesive theme around cell cycle control and proliferation. While there are a few unrelated terms (cadmium response, morphogenesis, transcription), the dominant signal is mitotic regulation, supporting a label focused on cell cycle checkpoints and proliferation control.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051436","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0031571","count":2},{"id":"GO:0071276","count":2},{"id":"GO:1904693","count":1}]},{"hash":"1892303711988052594","title":"Synaptic Trafficking and Neurite Growth","description":"The top GO terms cluster around synaptic processes (synaptic vesicle endocytosis, immunological synapse formation), cytoskeletal dynamics (actin polymerization-driven motility), and neuronal development (neuron projection growth). Supporting terms related to membrane trafficking and signaling (Golgi to plasma membrane transport, ubiquitination regulation, insulin signaling) tie these functions to synaptic function and neurite remodeling. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048488","count":2},{"id":"GO:0001771","count":2},{"id":"GO:0042997","count":2},{"id":"GO:0035426","count":2},{"id":"GO:1900044","count":2}]},{"hash":"637369768203405843","title":"Transcription Regulation and Cell Cycle Control","description":"The GO terms point to transcriptional regulation (DNA-templated transcription; transcription factor localization) and cell cycle control (mitotic spindle pole separation regulation; spindle assembly checkpoint deactivation), with additional signals related to growth and stress (growth hormone response; GCN2 signaling) and apoptosis. This suggests a cluster of proteins that coordinate gene expression with cell cycle progression and cellular stress responses.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060416","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0010697","count":2},{"id":"GO:0061586","count":2},{"id":"GO:0060733","count":2}]},{"hash":"2227977589859311286","title":"Neural glutamate handling and neuromuscular signaling","description":"This cluster shows signals related to glutamate transport and reuptake (glutamate handling), along with neural development and neuromuscular functions such as motor neuron differentiation and posture control, and Schwann cell migration. The co-occurrence of glutamatergic processes with neural and glial development suggests a theme around how neurons manage glutamate signaling in development and maintenance of neural circuits. Some terms (vesicle transport, stress responses) are broader, which lowers overall cohesion, so I assign a medium level of confidence.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002037","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0010917","count":1},{"id":"GO:0008631","count":1},{"id":"GO:0050884","count":1}]},{"hash":"76430760085269488","title":"Spinal cord neuron and motor neuron development","description":"The terms point to neural development in the spinal cord, especially motor neuron differentiation and interneuron specification, with supporting ectoderm-derived processes like roof of mouth development; together they form a coherent theme of spinal cord neural differentiation and motor neuron fate decisions.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":2},{"id":"GO:0001705","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0021521","count":2},{"id":"GO:0035852","count":2}]},{"hash":"1271909551217992184","title":"Dendrite Morphogenesis & Ion Transport","description":"The top GO terms concentrate on nervous system functions, especially dendrite morphogenesis and potassium ion transport, with supporting signals for neuronal development and sensory perception of pain. While some terms are broad or obsolete, the prominent neural-related terms suggest a cluster centered on neuronal development and ion handling rather than a single pathway. Confidence is medium due to limited connectivity and mixed terms.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0046827","count":4},{"id":"GO:0006813","count":4},{"id":"GO:0048813","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1492856167636423927","title":"Embryonic development and differentiation regulation","description":"The GO terms show broad regulatory roles in development and differentiation, including epigenetic transcriptional control (negative regulation of transcription and histone methylation) and diverse embryonic processes (placenta, cartilage, endocrine development, heart EMT, pancreatic cell development, trophoblast differentiation, left-right patterning). This suggests a cluster of proteins that broadly regulate embryogenesis and lineage specification rather than a single pathway.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0061086","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2}]},{"hash":"1774050847932568084","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":1},{"id":"GO:0006289","count":1},{"id":"GO:1902800","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0042493","count":1}]},{"hash":"300665650114899433","title":"Developmental Regulation Across Tissues","description":"The top GO terms indicate broad roles in embryonic development and tissue specification across diverse organs (somites, liver, midbrain, spleen, AV node) plus transcriptional regulation and vitamin D responsiveness. This suggests the cluster comprises factors involved in general developmental regulation rather than a single, cohesive pathway, hence a label centered on multi-tissue development fits best.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0001757","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0030901","count":2}]},{"hash":"2012564056294380651","title":"Neuronal development and synaptic signaling","description":"The terms converge on nervous system and hippocampal development, excitatory synaptic activity, and signals guiding synapse formation (ephrin and Wnt pathways) plus calcium-driven exocytosis, all pointing to proteins involved in establishing and modulating excitatory synapses in neurons. The SRP-mediated targeting to membranes supports synaptic protein localization, consistent with a synaptic development theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0006614","count":3},{"id":"GO:0048013","count":2},{"id":"GO:0000186","count":2}]},{"hash":"1224197954578174094","title":"Neural development and Wnt signaling","description":"The GO terms cluster around neural differentiation (stem cell and neuron differentiation, CNS development) and Wnt signaling (canonical and planar cell polarity) with associated cell\u2013cell adhesion, indicating a neural development-focused signaling module. While angiogenesis and growth terms appear, the dominant theme is neural differentiation and Wnt pathway regulation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048863","count":3},{"id":"GO:0032436","count":2},{"id":"GO:0030182","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0001525","count":2}]},{"hash":"1029192675439915692","title":"Purine nucleotide biosynthesis and salvage","description":"Most of the GO terms are tied to nucleotide metabolism: AMP salvage, ADP and CDP biosynthesis, nucleoside monophosphate phosphorylation, and purine ribonucleotide interconversion. These signals suggest a cluster centered on purine nucleotide biosynthesis and salvage pathways. The liver and brain development terms likely reflect broader or incidental annotations rather than core functions of the cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046939","count":3},{"id":"GO:0046041","count":3},{"id":"GO:0044209","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0046705","count":3}]},{"hash":"463126044469584588","title":"Vacuole transport and ion homeostasis","description":"Most GO terms point to vacuolar function: vacuole organization, protein targeting to vacuole, vacuolar acidification, and vacuole-related transport. Additional terms cover ion homeostasis and transmembrane proton/ion flux (sodium, copper) and related ATP dynamics, suggesting a cluster centered on vacuolar trafficking and ion balance.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007033","count":1},{"id":"GO:0006814","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0006623","count":1},{"id":"GO:0006878","count":1}]},{"hash":"393102976087984976","title":"DNA maintenance and translation","description":"This cluster shows strong signals for translation (protein synthesis) alongside DNA replication, repair, and telomere maintenance terms, plus tRNA aminoacylation/modification including mitochondrial tRNA processes. The combination suggests a link between nucleic acid maintenance and translation-related activities, possibly reflecting multifunctional or dual-localized proteins. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0010833","count":2},{"id":"GO:0071915","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0007093","count":2}]},{"hash":"1989960148060150378","title":"N-terminal protein methylation","description":"This cluster\u2019s GO terms are dominated by specific N-terminal methylation events (serine dimethylation/trimethylation, lysine dimethylation, general methylation) and related post-translational modifications, suggesting involvement of N-terminal methyltransferases. A few stress-related responses (lipopolysaccharide, xenobiotic) appear due to broader signaling connections but are not central to the main theme. Therefore, labeling it as N-terminal protein methylation captures the primary functional motif.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0001887","count":1},{"id":"GO:0042220","count":1},{"id":"GO:0035572","count":1},{"id":"GO:0035573","count":1}]},{"hash":"2249647239431563573","title":"Unknown","description":"The top GO terms span very different processes (centriole elongation, ribosomal subunit assembly, mitochondrial inner membrane insertion and complex III assembly, nonfunctional rRNA decay, autophagy, FAD catabolic process, DNA replication checkpoint, gas vesicle organization, protein unfolding). There isn\u2019t a single cohesive theme tying these functions together, so a generic Unknown label with no confidence is most appropriate.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903724","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0032979","count":2},{"id":"GO:0070651","count":2},{"id":"GO:0061738","count":2}]},{"hash":"1380030732136806976","title":"Spliceosome-Driven RNA Processing","description":"The top GO terms cluster around spliceosome-mediated mRNA splicing (negative/positive regulation and alternative splicing) and related RNA maturation steps (mRNA export, stabilization, and small-subunit processome assembly), with additional hints of translation initiation complex formation. This pattern points to proteins involved in RNA processing and spliceosome function, along with associated ribosome biogenesis/translation readiness, justifying a label centered on RNA processing driven by the spliceosome.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":3},{"id":"GO:0048025","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0048026","count":3}]},{"hash":"1572117701035838160","title":"Notch-driven embryonic organogenesis","description":"Top terms suggest that Notch signaling governs diverse organogenesis processes, including heart morphogenesis, neural/glial lineage specification, and airway/retina development; the cluster likely represents Notch-regulated developmental regulators. A xenobiotic response term is present but does not override the main theme.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":3},{"id":"GO:0072282","count":3},{"id":"GO:0009410","count":3},{"id":"GO:0003062","count":3},{"id":"GO:0021781","count":3}]},{"hash":"1216295545526711599","title":"Keratinocyte development and hair follicle formation","description":"The GO terms show strong signals for keratinocyte development and hair follicle placode formation, indicating epidermal/skin differentiation as the central theme of this cluster. Additional terms point to related epithelial processes such as focal adhesion, Golgi vesicle budding, and regulation of gene expression, suggesting a skin/epithelial function context rather than a single isolated pathway. Overall, the terms converge around skin development with some supporting cellular process terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006384","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0003334","count":1},{"id":"GO:0046330","count":1},{"id":"GO:1990261","count":1}]},{"hash":"931159457342884977","title":"RNA Splicing Regulation and Translation Control","description":"The top GO terms are dominated by spliceosome-mediated regulation of mRNA splicing (negative/positive regulation, alternative splicing), with additional terms related to translation initiation/elongation, including viral termination-reinitiation. This points to a small cluster of proteins involved in RNA processing and control of translation, possibly with roles in early development (oocyte/oskar localization and axis specification). ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":3},{"id":"GO:0048025","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0045451","count":3}]},{"hash":"2075811844375360260","title":"Unknown","description":"The GO terms are highly diverse, spanning glycolytic metabolism, amino acid/propane-related catabolic processes, RNA splicing, oxidative stress response, neural development, neuron projection growth, sperm capacitation, fungicide response, and cell size regulation. There isn\u2019t a single coherent function or pathway that ties these terms together for the cluster, so a specific, descriptive label isn\u2019t apparent.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006096","count":1},{"id":"GO:2000179","count":1},{"id":"GO:0060992","count":1},{"id":"GO:0010976","count":1},{"id":"GO:0048240","count":1}]},{"hash":"2247699165628048934","title":"Unknown","description":"The GO terms span adhesion, cuticle development, metal ion transport, redox/stress responses, and gravity sensing, with no clear single theme linking them; no interactions are evident (Edges 0), so a coherent cluster function can\u2019t be determined.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0045726","count":1},{"id":"GO:0008365","count":1},{"id":"GO:1990451","count":1},{"id":"GO:0045453","count":1}]},{"hash":"972197958715863988","title":"Unknown","description":"The GO terms span diverse processes (ubiquitination regulation, muscle contraction, skin development, host\u2013virus interaction, chromatin modification, signaling cascades, calcium signaling, and neural synapse assembly), with no clear shared function to unify the proteins, so a concise, representative cluster label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090086","count":2},{"id":"GO:0006936","count":2},{"id":"GO:0043588","count":2},{"id":"GO:1902187","count":2},{"id":"GO:0070535","count":2}]},{"hash":"1286479397045559731","title":"Neural development and one-carbon metabolism","description":"The enriched terms point to neural development (neural precursor proliferation, neuron projection development) and methylation-related metabolism (methionine cycle, methylation, choline catabolism), with some neuroendocrine context (pituitary development) and dopamine metabolism. This suggests a cluster of proteins coordinating brain development with one-carbon metabolism, hence the label.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033353","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0045471","count":1},{"id":"GO:0046168","count":1},{"id":"GO:2000179","count":1}]},{"hash":"461126080604970646","title":"Transcriptional Regulation and Circadian Expression","description":"The top GO terms cluster around transcription control (DNA-templated transcription, regulation of transcription) and circadian regulation of gene expression, indicating these proteins likely participate in gene expression regulation with circadian dynamics. Some other terms touch on neural development and cellular responses, which may reflect broader roles or annotation overlaps, but the core pattern is transcriptional regulation linked to circadian expression.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006935","count":2},{"id":"GO:0061030","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0009410","count":2},{"id":"GO:0061419","count":2}]},{"hash":"580086884261260141","title":"Unknown","description":"The GO terms span vesicle transport, respiration, transcription regulation, signaling, cytoskeleton modulation, phagolysosome formation, apoptosis, and fungal cell wall-related processes, with no single dominant function linking the proteins. The cluster appears heterogeneous with no clear unifying theme, so Unknown with no confident label is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0022904","count":1},{"id":"GO:0060416","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0061586","count":1}]},{"hash":"1102364240318794750","title":"Hematopoiesis and Immune Lineage Differentiation","description":"The GO terms are dominated by differentiation processes of immune and hematopoietic lineages (T cell, myeloid, lymphocyte differentiation, and definitive hemopoiesis), with related notes on bone formation, suggesting a cluster centered on blood/immune cell lineage development rather than a single specific pathway. This supports a label capturing the broad differentiation theme across hematopoietic and immune cells.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046632","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0060047","count":1},{"id":"GO:0035206","count":1},{"id":"GO:0060216","count":1}]},{"hash":"2012690399584944729","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045216","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0072300","count":1},{"id":"GO:0086073","count":1},{"id":"GO:0003273","count":1}]},{"hash":"623631782353676470","title":"Tissue morphogenesis and remodeling","description":"The terms point to developmental processes and structural remodeling across tissues: salivary gland morphogenesis and branching, blood vessel remodeling, and related structural assembly (protein homooligomerization and cross-linking). A couple of terms (e.g., mating plug formation) are less consistent with this theme, but the dominant signal is morphogenesis and remodeling of tissues. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048661","count":1},{"id":"GO:0051482","count":1},{"id":"GO:0006058","count":1},{"id":"GO:0060662","count":1},{"id":"GO:0001974","count":1}]},{"hash":"575956617621677926","title":"Nuclear RNA localization and telomere maintenance","description":"These terms point to nuclear RNA processing/localization to Cajal bodies (scaRNA and telomerase RNA localization) and protein localization to telomeres, with ancillary links to nuclear pore assembly and cell cycle, suggesting a nuclear/teleomere\u2013associated function cluster.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051086","count":3},{"id":"GO:0007339","count":3},{"id":"GO:0090666","count":3},{"id":"GO:1904874","count":3},{"id":"GO:1901998","count":3}]},{"hash":"84103808820855719","title":"Developmental differentiation and hormone signaling","description":"The GO terms converge on differentiation across multiple tissues and development (fat cell, heart, Sertoli, vagina) and include nuclear hormone receptor pathways (retinoic acid, thyroid hormone) and transcriptional regulation, indicating a cohesive cluster tied to developmental regulation modulated by hormones.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006351","count":1},{"id":"GO:0021872","count":1},{"id":"GO:0060008","count":1}]},{"hash":"1086133762335354151","title":"Developmental Transcriptional Regulation","description":"The GO terms span multiple tissue-specific developmental processes (forebrain, amygdala, Sertoli, vagina, heart) and include DNA-templated transcription and hormone signaling (retinoic acid and thyroid hormone pathways), suggesting a common theme of developmental gene regulation rather than a single tissue function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":1},{"id":"GO:0021872","count":1},{"id":"GO:0060008","count":1},{"id":"GO:0060068","count":1},{"id":"GO:0042953","count":1}]},{"hash":"901864540618636809","title":"Nuclear DNA replication and ubiquitination","description":"This cluster is dominated by nuclear processes: DNA replication and protein ubiquitination (including K6-linked ubiquitination), suggesting roles in genome maintenance and chromatin regulation. Additional terms point to stress responses and apoptosis, which can impact genome integrity, while a few histone modification terms (obsolete notes) hint at epigenetic regulation. Overall, a coherent theme around nuclear regulation of DNA replication and protein turnover emerges.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0098907","count":2}]},{"hash":"2293085246034970240","title":"Sulfur-Dependent tRNA Modifications and Redox","description":"The GO terms point to sulfur metabolism and RNA modification pathways: tRNA wobble uridine thiolation and tRNA seleno-modification, along with transsulfuration, cysteine-related modifications, and molybdenum cofactor biosynthesis. URM1/urmylation is known to support tRNA thiolation, linking sulfur transfer to RNA modification. Redox homeostasis further supports a sulfur- and redox-centered functional theme. Some developmental terms appear incidental to the core biochemical signals.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006777","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0032447","count":2},{"id":"GO:0002143","count":2}]},{"hash":"2029941748467821103","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008625","count":2},{"id":"GO:0075525","count":1},{"id":"GO:0048025","count":1},{"id":"GO:0001825","count":1},{"id":"GO:0001731","count":1}]},{"hash":"1211012597269123795","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034476","count":2},{"id":"GO:0006268","count":2},{"id":"GO:0070870","count":2},{"id":"GO:0000390","count":2},{"id":"GO:0006363","count":2}]},{"hash":"1117484517858945975","title":"Neuronal development and signaling","description":"The terms cluster around neuronal development and signaling (dendrite self-avoidance, synaptic plasticity, behavior), suggesting a neural function theme, though a few terms are unrelated, likely noise in a small cluster.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902955","count":3},{"id":"GO:0048671","count":3},{"id":"GO:0070593","count":3},{"id":"GO:0060068","count":3},{"id":"GO:0045163","count":3}]},{"hash":"2222065189563000540","title":"Ribosome Biogenesis and Translation","description":"The top GO terms cluster around ribosome assembly, biogenesis, export of ribosomal subunits, and cytoplasmic translation, with supporting terms like tRNA modification, indicating a core focus on ribosome production and protein synthesis; a couple of cell cycle/division terms appear but likely reflect growth-related coupling rather than a primary function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0090529","count":2}]},{"hash":"1333954598081969251","title":"Ubiquitin-Mediated Protein Quality Control","description":"These proteins are linked to ubiquitination processes (protein ubiquitination, autoubiquitination), SUMOylation (protein sumoylation), and degradation pathways (ERAD), as well as aggresome formation and PML body organization, indicating a shared role in protein quality control via ubiquitin/SUMO modifications. The immune signaling terms present may reflect ubiquitin's broader regulatory role but do not outweigh the proteostasis theme. Overall, the cluster points to tagging and processing misfolded proteins for clearance.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070842","count":2},{"id":"GO:0034126","count":2},{"id":"GO:1901896","count":2},{"id":"GO:1903265","count":2},{"id":"GO:0030578","count":2}]},{"hash":"1046284540936731940","title":"Calcium and membrane ion regulation in muscle","description":"The top GO terms center on calcium homeostasis (Golgi and intracellular), sodium and other metal ion transport, membrane repolarization, and regulation of muscle contraction/relaxation, including cardiac and striated muscle. This points to a cohesive theme of ion handling that directly modulates muscle function, with calcium signaling as a key thread, hence the chosen label.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032468","count":1},{"id":"GO:0070574","count":1},{"id":"GO:0090076","count":1},{"id":"GO:0036376","count":1},{"id":"GO:0006874","count":1}]},{"hash":"1724323198157429023","title":"Spindle assembly and microtubule dynamics","description":"The GO terms point to microtubule behavior and spindle-related processes (pole separation, plus-end depolymerization/sliding, meiotic spindle orientation, and karyogamy), with additional cytoskeletal roles in actomyosin ring formation and cell adhesion, indicating a focus on cytoskeletal organization during division.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000073","count":3},{"id":"GO:0001560","count":3},{"id":"GO:0070462","count":3},{"id":"GO:0000915","count":3},{"id":"GO:0033624","count":3}]},{"hash":"628905917679093064","title":"Mesoderm Formation and Stem Cell Differentiation","description":"The top GO terms center on mesoderm formation and positive regulation of stem cell differentiation, supported by signals related to muscle activity response, nitric oxide signaling, and VEGF/PDGF pathways, as well as nuclear transcription and DNA replication. This pattern points to a developmental program focused on mesoderm emergence and progenitor cell fate decisions, with accompanying proliferation and extracellular matrix remodeling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000320","count":3},{"id":"GO:0014850","count":3},{"id":"GO:0006351","count":3},{"id":"GO:2000738","count":3},{"id":"GO:0001707","count":3}]},{"hash":"1192554744008030794","title":"ECM Remodeling and Development","description":"The terms cluster around extracellular matrix organization (collagen fibril organization, collagen-activated signaling, intramembranous ossification) and tissue development (skin development, endodermal differentiation, podocyte development). Cilium assembly also ties into developmental signaling and structural assembly, suggesting a theme of connective-tissue remodeling and organogenesis, with immune terms present but less central. Overall, the dominant signal points to ECM-related development.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":1},{"id":"GO:0001867","count":1},{"id":"GO:0038063","count":1},{"id":"GO:0001771","count":1},{"id":"GO:0035987","count":1}]},{"hash":"2260175282123805545","title":"Cardiac Morphogenesis and Calcium Regulation","description":"This cluster is enriched for GO terms tied to heart development and function, including ventricular morphogenesis, heart trabecula formation, and regulation of cardiac conduction, as well as negative regulation of ryanodine receptor\u2013mediated calcium release, pointing to a cohesive cardiac developmental/functional theme. Additional terms on protein folding, sumoylation, and amyloid-related processes may reflect general cellular stress or housekeeping functions that accompany cardiac tissue biology.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055010","count":2},{"id":"GO:1903779","count":2},{"id":"GO:0032925","count":2},{"id":"GO:0060315","count":2},{"id":"GO:0042026","count":2}]},{"hash":"582548879513958312","title":"RNA Processing and Gene Silencing","description":"This cluster is dominated by RNA-level regulation terms: miRNA processing, siRNA processing, mRNA processing, post-transcriptional gene silencing, and mRNA destabilization, suggesting a shared role in RNA processing and RNA interference pathways, with other terms representing contextual or ancillary roles.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010087","count":1},{"id":"GO:0035196","count":1},{"id":"GO:0030422","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0016441","count":1}]},{"hash":"538883840239950573","title":"Neural development and synaptic signaling","description":"This cluster features GO terms tied to neural development (lateral ventricle development, Purkinje cell migration) alongside synaptic receptor regulation and endocytosis (AMPA receptor activity regulation, clathrin-mediated and receptor-mediated endocytosis). Also present are signaling pathway regulations (Wnt/PCP, Notch), pointing to developmental processes shaping neural connectivity and synaptic function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903077","count":1},{"id":"GO:0035026","count":1},{"id":"GO:0021942","count":1},{"id":"GO:2000096","count":1},{"id":"GO:2000370","count":1}]},{"hash":"2253338703570737494","title":"Unknown","description":"The top GO terms are highly diverse, spanning plant development (stamen formation, chlorophyll biosynthetic process, hair follicle placode formation) and animal processes (lymph node development, positive regulation of interleukin-6/IL-8 production), plus protein homeostasis (proteasome assembly, ubiquitin-dependent protein catabolic process) and signaling regulation. With only a single edge and no coherent shared function, there is no clear theme tying these proteins together, so the cluster cannot be reliably labeled beyond Unknown.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048455","count":1},{"id":"GO:0043248","count":1},{"id":"GO:0015995","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0045416","count":1}]},{"hash":"862565048229121077","title":"Plant flavonoid and lignin biosynthesis","description":"The top GO terms cluster around biosynthetic processes for plant polyphenols: quercetin, kaempferol, cyanidin, and genistein biosynthesis, as well as lignin metabolism. This suggests a cohesive theme of secondary metabolite and cell-wall component production in plants. Some terms (paranode localization, estrogen/antibiotic metabolism) are less clearly connected and may reflect broader annotations or noise, but the dominant signal is flavonoid and lignin biosynthesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":2},{"id":"GO:0033303","count":2},{"id":"GO:0016999","count":2},{"id":"GO:0006711","count":2},{"id":"GO:0033485","count":2}]},{"hash":"1207561829461920584","title":"Synaptic vesicle trafficking and endocytosis","description":"The GO terms emphasize vesicle transport, endocytosis, and synaptic vesicle cycling (budding, recycling) along with Golgi-to-ER/vacuolar transport, pointing to a cohesive vesicle trafficking module tied to synaptic and endosomal pathways as well as Golgi dynamics.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":1},{"id":"GO:0048488","count":1},{"id":"GO:0048313","count":1},{"id":"GO:0008344","count":1},{"id":"GO:0035646","count":1}]},{"hash":"612807533649903587","title":"Unknown","description":"The GO terms are highly diverse, spanning muscle contraction regulation and attachment to olfactory nerve organization, mRNA export, chromatin formation, fatty acid biosynthesis, and vasculogenesis. There is no single cohesive biological theme connecting all proteins, suggesting the cluster does not share a clear common function.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014809","count":2},{"id":"GO:1901016","count":2},{"id":"GO:0016203","count":2},{"id":"GO:0021629","count":2},{"id":"GO:0010793","count":2}]},{"hash":"1921030385142777205","title":"Forebrain and PNS neural development","description":"The proteins are aligned with neural development terms, especially forebrain-related processes (forebrain-midbrain boundary formation, subpallium development, forebrain cell proliferation) and peripheral nervous system neuron development, suggesting a cluster of genes involved in early brain patterning and PNS formation. Some terms reference non-neural tissues (bronchiole development, pancreatic alpha cell development) or differentiation regulation in skin and muscle, indicating some noise but not overpowering the neural signal.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021920","count":2},{"id":"GO:0003322","count":2},{"id":"GO:0021905","count":2},{"id":"GO:0060435","count":2},{"id":"GO:1902723","count":2}]},{"hash":"2083433845599388630","title":"Developmental transcription regulation and chromatin modification","description":"These proteins appear linked to controlling gene expression during development and to chromatin state (regulation of DNA-templated transcription, histone H4-K20 trimethylation/heterochromatin formation). Supporting terms touch on developmental programs (chondrocyte differentiation, embryonic skeletal system development, follicle cell formation) and broader regulatory processes, pointing to a theme of developmental gene regulation with chromatin context rather than a single specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032332","count":2},{"id":"GO:0035190","count":1},{"id":"GO:0048635","count":1},{"id":"GO:0030713","count":1},{"id":"GO:0043249","count":1}]},{"hash":"1671676894239676953","title":"Unknown","description":"Top GO terms are mostly neuronal-related (neuron projection development, dendrite self-avoidance, synaptic plasticity, MAPK regulation) but also include unrelated terms (vagina development, striated muscle myosin thick filament assembly, potassium channel clustering) and there are no edges connecting members. This scattered set of annotations does not support a single coherent function for the cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902955","count":1},{"id":"GO:0010976","count":1},{"id":"GO:0048671","count":1},{"id":"GO:0070593","count":1},{"id":"GO:0060068","count":1}]},{"hash":"2026991675609063564","title":"TNF/NF-kB signaling and apoptosis regulation","description":"The shared terms center on TNF-mediated signaling, NF-\u03baB activation (I-kappaB phosphorylation), and regulation of apoptosis, supported by ubiquitination processes; a few terms relate to immune system gene regulation (V(D)J recombination) and chromatin regulation, but the dominant theme is TNF/NF-\u03baB\u2013driven immune signaling and cell death control.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042981","count":3},{"id":"GO:0009048","count":3},{"id":"GO:0036205","count":3},{"id":"GO:1903762","count":3},{"id":"GO:0033209","count":3}]},{"hash":"1609224397692791682","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903215","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0007275","count":1},{"id":"GO:0045676","count":1},{"id":"GO:0002047","count":1}]},{"hash":"1165273764063844203","title":"Neural development and axon guidance","description":"The terms highlight neuronal development processes such as axon extension and guidance, synapse assembly, and neuronal migration, with supporting themes in epithelial polarity and extracellular matrix organization. This suggests the proteins collectively relate to neural development and pathfinding rather than a single other function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061364","count":2},{"id":"GO:0019800","count":2},{"id":"GO:0016336","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0090260","count":2}]},{"hash":"1701828764413984000","title":"Cardiovascular inflammation and renin-angiotensin signaling","description":"The terms center on vascular and inflammatory processes (regulation of ECM assembly, endothelial migration, monocyte chemotaxis, cardiac conduction) and renin-angiotensin\u2013related effects (angiotensin-mediated drinking behavior, renal response to blood flow). While a few terms touch neural development, the predominant pattern points to cardiovascular inflammation and angiotensin signaling, suggesting a rough cohesive theme despite some heterogeneity. ","confidence":"Low","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901201","count":1},{"id":"GO:0010976","count":1},{"id":"GO:0001999","count":1},{"id":"GO:0002438","count":1},{"id":"GO:0010596","count":1}]},{"hash":"1657643428467916229","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitination and proteasome-related processes (ubiquitin-dependent catabolic process, polyubiquitination, aggresome assembly), with connections to stress responses and apoptosis regulation. While there are a few terms touching on viral interactions and signaling, the core theme across the cluster is ubiquitin-mediated protein turnover, suggesting roles in tagging/degrading proteins and managing cellular stress.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:1902187","count":2},{"id":"GO:0048535","count":2},{"id":"GO:0009896","count":2},{"id":"GO:0048384","count":2}]},{"hash":"1116978187947355078","title":"T cell differentiation and antiviral immune regulation","description":"The top GO terms cluster around T cell differentiation (T follicular helper cell differentiation; regulation of T-helper cell differentiation) and antiviral/immune signaling (suppression of viral release by host; non-canonical NF-kappaB signaling; regulation of apoptotic process; ubiquitination; nitric-oxide synthase regulation). This suggests the proteins participate in immune regulation, particularly in T cell lineage decisions and antiviral host responses, rather than a single enzymatic or structural role. The evidence is indirect and based on term enrichment, with no interaction edges, so the label expresses a plausible functional theme rather than a tightly connected module.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902187","count":2},{"id":"GO:0048535","count":2},{"id":"GO:0009896","count":2},{"id":"GO:0050999","count":2},{"id":"GO:0097039","count":2}]},{"hash":"1810742993005441287","title":"NF-kappaB-Related Immune Signaling","description":"The top GO terms cluster around regulation of NF-kappaB activity, ubiquitin-related control of deubiquitination, and immune-system processes (lymph node development, germinal center formation), along with host defense aspects (suppression of viral release, host-mediated suppression of symbiont invasion). Even though there are no edges among the proteins, these terms together point to a theme of NF-kappaB\u2013mediated immune signaling and ubiquitin-regulated defense mechanisms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0090086","count":2},{"id":"GO:1901536","count":2},{"id":"GO:1902187","count":2},{"id":"GO:0036353","count":2}]},{"hash":"1627966834096277257","title":"Notch signaling in skin remodeling","description":"The top terms center on Notch signaling (Notch pathway and Notch receptor processing), with accompanying terms for keratinocyte migration and collagen fibril organization, suggesting a Notch-influenced skin remodeling/wound-healing context. Immune-related terms are present but secondary to the Notch and epidermal remodeling theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045959","count":1},{"id":"GO:0035625","count":1},{"id":"GO:0007219","count":1},{"id":"GO:0034612","count":1},{"id":"GO:0032331","count":1}]}]