{"hash":"1749223400650524632","title":"Mitochondrial translation and respiration in neurons","description":"This cluster is dominated by GO terms related to mitochondrial gene expression and energy production: mitochondrial translation, regulation of translation, maturation of SSU-rRNA, ribosome biogenesis, and proton motive force-driven ATP synthesis, plus assembly of the mitochondrial respiratory chain (complex II). The presence of hypoxia response and apoptosis terms suggests mitochondrial stress signaling, while substantia nigra development and glucose-response regulation hint at brain-specific metabolic contexts. Collectively, the terms point to mitochondrial protein synthesis and respiration as the core theme in neural cells.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"members":[{"accession":"NP_001184219.1","go_terms":["GO:0061179","GO:0042775"]},{"accession":"NP_001232234.1","go_terms":["GO:0015986","GO:0099132"]},{"accession":"NP_001232301.1","go_terms":["GO:0006412"]},{"accession":"XP_002194813.2","go_terms":["GO:0055010","GO:0050684","GO:0001822","GO:0048747","GO:0001889"]},{"accession":"XP_012433721.5","go_terms":["GO:0033617"]},{"accession":"XP_030112048.4","go_terms":["GO:0030150"]},{"accession":"XP_030129450.4","go_terms":["GO:0018293","GO:0010719","GO:0017013","GO:0006121","GO:0006105","GO:0034553"]},{"accession":"XP_030141917.4","go_terms":[]},{"accession":"XP_041572084.2","go_terms":["GO:0006919","GO:0090200","GO:0051402","GO:0071456"]},{"accession":"XP_072783519.1","go_terms":[]},{"accession":"NP_001232035.1","go_terms":["GO:0097428","GO:0006879","GO:0009399","GO:0016226"]},{"accession":"XP_030129198.4","go_terms":["GO:0070475"]},{"accession":"XP_002193680.4","go_terms":["GO:0030490","GO:0042254"]},{"accession":"NP_001232085.1","go_terms":["GO:0015986","GO:0035786","GO:0021762"]},{"accession":"NP_001232255.1","go_terms":["GO:0032543"]},{"accession":"NP_001232624.1","go_terms":["GO:0034553","GO:0006120"]},{"accession":"XP_002199111.4","go_terms":["GO:0000470","GO:0006417","GO:0006412"]},{"accession":"XP_004176991.4","go_terms":["GO:0007613","GO:0061436","GO:0010043","GO:0090002","GO:0051894","GO:0050729","GO:0051496","GO:0043123","GO:0030593","GO:0051290","GO:0050832","GO:0008360","GO:0051597","GO:0042326","GO:0030194","GO:0001765","GO:2001015","GO:0032496","GO:0048168","GO:0043542","GO:0043303","GO:0050703","GO:0071456","GO:0045917","GO:0045087","GO:0008016","GO:0048708","GO:0042060","GO:0034142","GO:0014002","GO:0002523","GO:0051602","GO:0031640","GO:0048143","GO:0021762","GO:0002526","GO:0000122","GO:1900026","GO:0043163","GO:2001244","GO:0008284","GO:0035606","GO:0032119","GO:0007409","GO:0051092","GO:0060291","GO:0051099","GO:0042493","GO:0002544","GO:0051384","GO:0032602","GO:0090026","GO:0031532","GO:0046688","GO:1901387","GO:0071624","GO:0045113","GO:0006919","GO:0042107","GO:0006915","GO:0045471","GO:0070488","GO:0051592","GO:0002793","GO:0001837","GO:0006417"]},{"accession":"XP_030118834.4","go_terms":[]},{"accession":"XP_030146267.1","go_terms":["GO:0033119","GO:0000462","GO:0006417","GO:0006378","GO:0006412"]},{"accession":"XP_041576544.2","go_terms":["GO:0042747","GO:0008211","GO:0097498","GO:0071373","GO:0071378","GO:1900119","GO:0080060","GO:0006701","GO:0035621","GO:0032782","GO:0035360","GO:0003007","GO:0048497","GO:0010879","GO:0010873","GO:0010072","GO:0032367","GO:0090051","GO:0070859","GO:0070508","GO:0031426","GO:0048507","GO:0010239","GO:0080163","GO:0006744","GO:0043086"]},{"accession":"XP_072780312.1","go_terms":["GO:0030490","GO:0042254"]}],"graph":[["XP_041576544.2","NP_001184219.1",0.974],["XP_041576544.2","NP_001232035.1",0.989],["XP_041576544.2","NP_001232085.1",0.991],["XP_041576544.2","NP_001232234.1",0.99],["XP_041576544.2","NP_001232255.1",0.985],["XP_041576544.2","NP_001232301.1",0.977],["XP_041576544.2","NP_001232624.1",0.975],["XP_041576544.2","XP_002193680.4",0.986],["XP_041576544.2","XP_002194813.2",0.982],["XP_041576544.2","XP_002199111.4",0.986],["XP_041576544.2","XP_004176991.4",0.986],["XP_041576544.2","XP_012433721.5",0.982],["XP_041576544.2","XP_030112048.4",0.986],["XP_041576544.2","XP_030118834.4",0.951],["XP_041576544.2","XP_030129198.4",0.984],["XP_041576544.2","XP_030129450.4",0.977],["XP_041576544.2","XP_030141917.4",0.98],["XP_041576544.2","XP_030146267.1",0.988],["XP_041576544.2","XP_041572084.2",0.973],["XP_041576544.2","XP_072780312.1",0.982],["XP_041576544.2","XP_072783519.1",0.955],["XP_072780312.1","NP_001184219.1",0.968],["XP_072780312.1","NP_001232035.1",0.981],["XP_072780312.1","NP_001232085.1",0.983],["XP_072780312.1","NP_001232234.1",0.985],["XP_072780312.1","NP_001232255.1",0.985],["XP_072780312.1","NP_001232301.1",0.977],["XP_072780312.1","NP_001232624.1",0.983],["XP_072780312.1","XP_002193680.4",0.976],["XP_072780312.1","XP_002194813.2",0.988],["XP_072780312.1","XP_002199111.4",0.986],["XP_072780312.1","XP_004176991.4",0.97],["XP_072780312.1","XP_012433721.5",0.991],["XP_072780312.1","XP_030112048.4",0.98],["XP_072780312.1","XP_030118834.4",0.987],["XP_072780312.1","XP_030129198.4",0.976],["XP_072780312.1","XP_030129450.4",0.989],["XP_072780312.1","XP_030141917.4",0.985],["XP_072780312.1","XP_030146267.1",0.972],["XP_072780312.1","XP_041572084.2",0.982],["XP_072780312.1","XP_072783519.1",0.974],["NP_001232301.1","NP_001184219.1",0.947],["NP_001232301.1","NP_001232035.1",0.974],["NP_001232301.1","NP_001232085.1",0.984],["NP_001232301.1","NP_001232234.1",0.977],["NP_001232301.1","NP_001232255.1",0.979],["NP_001232301.1","NP_001232624.1",0.96],["NP_001232301.1","XP_002193680.4",0.989],["NP_001232301.1","XP_002194813.2",0.987],["NP_001232301.1","XP_002199111.4",0.99],["NP_001232301.1","XP_00417699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