{"hash":"811396845426593733","title":"ER quality control and ERAD/retrograde transport","description":"The dominant GO terms point to endoplasmic reticulum localization (to ER membrane) and retrograde transport from the ER to the cytosol, which are core aspects of ER-associated degradation (ERAD) and ER quality control processes. A related term about localization to endosome suggests broader intracellular trafficking, but the ERAD/ER localization terms clearly anchor the cluster\u2019s function. The presence of an obsolete term for ubiquitin-dependent ERAD reinforces the theme, albeit with outdated wording. Overall, this cluster seems to group proteins involved in managing ER residency and clearance via ERAD pathways.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_069975724.1","go_terms":[]},{"accession":"XP_069979428.1","go_terms":[]},{"accession":"XP_069979455.1","go_terms":[]},{"accession":"XP_069982041.1","go_terms":[]},{"accession":"XP_069983487.1","go_terms":[]},{"accession":"XP_069988577.1","go_terms":[]},{"accession":"XP_069989658.1","go_terms":[]},{"accession":"XP_069990700.1","go_terms":[]},{"accession":"XP_069993197.1","go_terms":["GO:0010936","GO:0030433","GO:0097051","GO:0036010","GO:0030970"]},{"accession":"XP_069993592.1","go_terms":[]},{"accession":"XP_027207490.2","go_terms":[]}],"graph":[],"all_go_terms":{"GO:0010936":1,"GO:0036010":1,"GO:0030433":1,"GO:0030970":1,"GO:0097051":1},"recipe_readded":["XP_069973292.1","XP_027208838.1"]}