{"hash":"1415565474141323994","title":"Chromatin regulation and nuclear organization","description":"This cluster is dominated by terms related to chromatin dynamics and transcription control, including negative regulation of transcription by RNA polymerase II, establishment of protein localization to chromatin, nucleus organization, DNA replication-dependent chromatin assembly, and rDNA/pericentric heterochromatin formation, plus sex-chromosome dosage compensation. These repeatedly point to chromatin remodeling and nuclear architecture as a unifying theme, with a few outliers (innate immune response in mucosa, midbrain morphogenesis) that may reflect broader roles or annotation overlap.","confidence":"High","size":21,"edges":205,"triangles":1239,"max_degree":20,"top_function":null,"members":[{"accession":"XP_027232512.1","go_terms":["GO:0030466","GO:0019731","GO:0031639","GO:0071169","GO:0008584","GO:0007296","GO:0035264","GO:0035023","GO:1904693","GO:0003344","GO:2000973","GO:0000122","GO:0034184","GO:0030543","GO:0002227","GO:0090230","GO:1902340","GO:0051290","GO:0007283","GO:0007338","GO:0007286","GO:0031509","GO:0006335","GO:0045618","GO:0042692","GO:0031508","GO:0000183","GO:1904815","GO:0061641","GO:0001649","GO:0071674","GO:0003209","GO:0045815","GO:0048477","GO:0033128","GO:0051572","GO:0070481","GO:0006997","GO:0007549","GO:0007420","GO:0035093","GO:0050830","GO:0061086","GO:1901837","GO:0008285","GO:0071392","GO:0043486","GO:0006334","GO:0006357"]},{"accession":"XP_069994008.1","go_terms":["GO:0035067","GO:0016358","GO:0048132","GO:0008211","GO:0002087","GO:0051567","GO:0050432","GO:0090309","GO:0001662","GO:0006349","GO:0021549","GO:0021591","GO:0042551","GO:0006346","GO:0001964","GO:0019230","GO:1900114","GO:0007585","GO:0051151","GO:0031061","GO:0044026","GO:0060079","GO:2000820","GO:0072325","GO:0042711","GO:0001976"]},{"accession":"XP_027210407.1","go_terms":["GO:0030466","GO:0019731","GO:0031639","GO:0071169","GO:0008584","GO:0007296","GO:0035264","GO:0035023","GO:1904693","GO:0003344","GO:2000973","GO:0000122","GO:0034184","GO:0030543","GO:0002227","GO:0090230","GO:1902340","GO:0051290","GO:0007283","GO:0007338","GO:0007286","GO:0031509","GO:0006335","GO:0045618","GO:0042692","GO:0031508","GO:0000183","GO:1904815","GO:0061641","GO:0001649","GO:0071674","GO:0003209","GO:0045815","GO:0048477","GO:0033128","GO:0051572","GO:0070481","GO:0006997","GO:0007549","GO:0007420","GO:0035093","GO:0050830","GO:0061086","GO:1901837","GO:0061408","GO:0043966","GO:0000436","GO:0043457","GO:1900446","GO:2000306","GO:0042766","GO:0045898"]},{"accession":"XP_027215954.2","go_terms":["GO:0030466","GO:0019731","GO:0031639","GO:0071169","GO:0008584","GO:0007296","GO:0035264","GO:0035023","GO:1904693","GO:0003344","GO:2000973","GO:0000122","GO:0034184","GO:0030543","GO:0002227","GO:0090230","GO:1902340","GO:0051290","GO:0007283","GO:0007338","GO:0007286","GO:0031509","GO:0006335","GO:0045618","GO:0042692","GO:0031508","GO:0000183","GO:1904815","GO:0061641","GO:0001649","GO:0071674","GO:0003209","GO:0045815","GO:0048477","GO:0033128","GO:0051572","GO:0070481","GO:0006997","GO:0007549","GO:0007420","GO:0035093","GO:0050830","GO:0061086","GO:1901837","GO:0061408","GO:0043966","GO:0000436","GO:0043457","GO:1900446","GO:2000306","GO:0042766","GO:0045898","GO:0008285","GO:0071392","GO:0043486","GO:0006334","GO:0006357"]},{"accession":"XP_027222686.1","go_terms":["GO:0061408","GO:0043966","GO:0000122","GO:0000436","GO:0043457","GO:1900446","GO:2000306","GO:0042766","GO:0045898"]},{"accession":"XP_027223260.1","go_terms":["GO:0030466","GO:0019731","GO:0031639","GO:0071169","GO:0008584","GO:0007296","GO:0035264","GO:0035023","GO:1904693","GO:0003344","GO:2000973","GO:0000122","GO:0034184","GO:0030543","GO:0002227","GO:0090230","GO:1902340","GO:0051290","GO:0007283","GO:0007338","GO:0007286","GO:0031509","GO:0006335","GO:0045618","GO:0042692","GO:0031508","GO:0000183","GO:1904815","GO:0061641","GO:0001649","GO:0071674","GO:0003209","GO:0045815","GO:0048477","GO:0033128","GO:0051572","GO:0070481","GO:0006997","GO:0007549","GO:0007420","GO:0035093","GO:0050830","GO:0061086","GO:1901837","GO:0061408","GO:0043966","GO:0000436","GO:0043457","GO:1900446","GO:2000306","GO:0042766","GO:0045898"]},{"accession":"XP_027223294.1","go_terms":["GO:0030466","GO:0019731","GO:0031639","GO:0071169","GO:0008584","GO:0007296","GO:0035264","GO:0035023","GO:1904693","GO:0003344","GO:2000973","GO:0000122","GO:0034184","GO:0030543","GO:0002227","GO:0090230","GO:1902340","GO:0051290","GO:0007283","GO:0007338","GO:0007286","GO:0031509","GO:0006335","GO:0045618","GO:0042692","GO:0031508","GO:0000183","GO:1904815","GO:0061641","GO:0001649","GO:0071674","GO:0003209","GO:0045815","GO:0048477","GO:0033128","GO:0051572","GO:0070481","GO:0006997","GO:0007549","GO:0007420","GO:0035093","GO:0050830","GO:0061086","GO:1901837","GO:0061408","GO:0043966","GO:0000436","GO:0043457","GO:1900446","GO:2000306","GO:0042766","GO:0045898","GO:0008285","GO:0071392","GO:0043486","GO:0006334","GO:0006357"]},{"accession":"XP_027215738.1","go_terms":["GO:1902455"]},{"accession":"XP_027216222.1","go_terms":["GO:0006412","GO:0000027"]},{"accession":"XP_027233390.2","go_terms":["GO:0046632","GO:0002181"]},{"accession":"XP_069974812.1","go_terms":[]},{"accession":"XP_027211098.2","go_terms":["GO:0022605","GO:0006924","GO:0000082","GO:0042274","GO:0007369","GO:0042254","GO:0043065","GO:0048821","GO:0002309","GO:0033077","GO:0031929","GO:0000462","GO:0031167","GO:0001890","GO:0006412","GO:0007093"]},{"accession":"XP_069971522.1","go_terms":[]},{"accession":"XP_069974664.1","go_terms":["GO:0030466","GO:0019731","GO:0031639","GO:0071169","GO:0008584","GO:0007296","GO:0035264","GO:0035023","GO:1904693","GO:0003344","GO:2000973","GO:0000122","GO:0034184","GO:0030543","GO:0002227","GO:0090230","GO:1902340","GO:0051290","GO:0007283","GO:0007338","GO:0007286","GO:0031509","GO:0006335","GO:0045618","GO:0042692","GO:0031508","GO:0000183","GO:1904815","GO:0061641","GO:0001649","GO:0071674","GO:0003209","GO:0045815","GO:0048477","GO:0033128","GO:0051572","GO:0070481","GO:0006997","GO:0007549","GO:0007420","GO:0035093","GO:0050830","GO:0061086","GO:1901837"]},{"accession":"XP_069984616.1","go_terms":[]},{"accession":"XP_027228873.2","go_terms":["GO:0016584","GO:0070828","GO:0006334","GO:0071169","GO:0098532","GO:0097298","GO:0080182"]},{"accession":"XP_027221302.2","go_terms":[]},{"accession":"XP_069974807.1","go_terms":[]},{"accession":"XP_069987722.1","go_terms":[]},{"accession":"XP_069989753.1","go_terms":[]},{"accession":"XP_069993162.1","go_terms":[]}],"graph":[["XP_027223260.1","XP_027210407.1",0.906],["XP_027223260.1","XP_027211098.2",0.767],["XP_027223260.1","XP_027215954.2",0.889],["XP_027223260.1","XP_027216222.1",0.695],["XP_027223260.1","XP_027221302.2",0.728],["XP_027223260.1","XP_027222686.1",0.956],["XP_027223260.1","XP_027223294.1",0.801],["XP_027223260.1","XP_027228873.2",0.7],["XP_027223260.1","XP_069974807.1",0.846],["XP_027223260.1","XP_069974812.1",0.926],["XP_027223260.1","XP_069974664.1",0.664],["XP_027223260.1","XP_069971522.1",0.812],["XP_027223260.1","XP_027233390.2",0.918],["XP_027223260.1","XP_027232512.1",0.968],["XP_027223260.1","XP_069987722.1",0.752],["XP_027223260.1","XP_069984616.1",0.856],["XP_027223260.1","XP_069993162.1",0.786],["XP_027223260.1","XP_069994008.1",0.778],["XP_027223260.1","XP_069989753.1",0.945],["XP_027223294.1","XP_027210407.1",0.778],["XP_027223294.1","XP_027211098.2",0.745],["XP_027223294.1","XP_027215738.1",0.925],["XP_027223294.1","XP_027215954.2",0.865],["XP_027223294.1","XP_027216222.1",0.638],["XP_027223294.1","XP_027221302.2",0.864],["XP_027223294.1","XP_027222686.1",0.871],["XP_027223294.1","XP_027228873.2",0.826],["XP_027223294.1","XP_069974807.1",0.857],["XP_027223294.1","XP_069974812.1",0.745],["XP_027223294.1","XP_069974664.1",0.876],["XP_027223294.1","XP_069971522.1",0.62],["XP_027223294.1","XP_027233390.2",0.937],["XP_027223294.1","XP_027232512.1",0.847],["XP_027223294.1","XP_069987722.1",0.92],["XP_027223294.1","XP_069984616.1",0.676],["XP_027223294.1","XP_069993162.1",0.828],["XP_027223294.1","XP_069994008.1",0.609],["XP_027223294.1","XP_069989753.1",0.879],["XP_069994008.1","XP_027232512.1",0.936],["XP_069994008.1","XP_027233390.2",0.921],["XP_069994008.1","XP_069971522.1",0.964],["XP_069994008.1","XP_069974664.1",0.739],["XP_069994008.1","XP_069974807.1",0.977],["XP_069994008.1","XP_069974812.1",0.967],["XP_069994008.1","XP_069984616.1",0.986],["XP_069994008.1","XP_069987722.1",0.968],["XP_069994008.1","XP_069989753.1",0.948],["XP_069994008.1","XP_069993162.1",0.963],["XP_069994008.1","XP_027210407.1",0.968],["XP_069994008.1","XP_027211098.2",0.942],["XP_069994008.1","XP_027215738.1",0.95],["XP_069994008.1","XP_027215954.2",0.757],["XP_069994008.1","XP_027216222.1",0.981],["XP_069994008.1","XP_027221302.2",0.959],["XP_069994008.1","XP_027222686.1",0.96],["XP_069994008.1","XP_027228873.2",0.801],["XP_069993162.1","XP_027232512.1",0.965],["XP_069993162.1","XP_027233390.2",0.843],["XP_069993162.1","XP_069971522.1",0.944],["XP_069993162.1","XP_069974664.1",0.881],["XP_069993162.1","XP_069974807.1",0.932],["XP_069993162.1","XP_069974812.1",0.969],["XP_069993162.1","XP_069984616.1",0.966],["XP_069993162.1","XP_069987722.1",0.91],["XP_069993162.1","XP_069989753.1",0.919],["XP_069993162.1","XP_027210407.1",0.967],["XP_069993162.1","XP_027211098.2",0.968],["XP_069993162.1","XP_027215738.1",0.899],["XP_069993162.1","XP_027215954.2",0.827],["XP_069993162.1","XP_027216222.1",0.968],["XP_069993162.1","XP_027222686.1",0.974],["XP_069993162.1","XP_027228873.2",0.909],["XP_027210407.1","XP_027228873.2",0.711],["XP_027210407.1","XP_027221302.2",0.931],["XP_027210407.1","XP_027222686.1",0.726],["XP_027210407.1","XP_027215738.1",0.608],["XP_027210407.1","XP_027215954.2",0.827],["XP_027210407.1","XP_027216222.1",0.96],["XP_027210407.1","XP_027211098.2",0.975],["XP_027210407.1","XP_069974807.1",0.987],["XP_027210407.1","XP_069974812.1",0.973],["XP_027210407.1","XP_069974664.1",0.897],["XP_027210407.1","XP_069971522.1",0.95],["XP_027210407.1","XP_027233390.2",0.98],["XP_027210407.1","XP_027232512.1",0.841],["XP_027210407.1","XP_069987722.1",0.958],["XP_027210407.1","XP_069984616.1",0.988],["XP_027210407.1","XP_069989753.1",0.972],["XP_069974664.1","XP_069984616.1",0.787],["XP_069974664.1","XP_069987722.1",0.756],["XP_069974664.1","XP_069989753.1",0.692],["XP_069974664.1","XP_027211098.2",0.87],["XP_069974664.1","XP_027215738.1",0.712],["XP_069974664.1","XP_027215954.2",0.77],["XP_069974664.1","XP_027216222.1",0.909],["XP_069974664.1","XP_027221302.2",0.87],["XP_069974664.1","XP_027222686.1",0.861],["XP_069974664.1","XP_027228873.2",0.598],["XP_069974664.1","XP_027232512.1",0.695],["XP_069974664.1","XP_027233390.2",0.9],["XP_069974664.1","XP_069971522.1",0.744],["XP_069974664.1","XP_069974807.1",0.916],["XP_069974664.1","XP_069974812.1",0.773],["XP_027215954.2","XP_027211098.2",0.758],["XP_027215954.2","XP_027228873.2",0.705],["XP_027215954.2","XP_027221302.2",0.825],["XP_027215954.2","XP_027222686.1",0.857],["XP_027215954.2","XP_027215738.1",0.907],["XP_027215954.2","XP_027216222.1",0.704],["XP_027215954.2","XP_069974807.1",0.86],["XP_027215954.2","XP_069974812.1",0.76],["XP_027215954.2","XP_069971522.1",0.541],["XP_027215954.2","XP_027233390.2",0.96],["XP_027215954.2","XP_027232512.1",0.836],["XP_027215954.2","XP_069987722.1",0.91],["XP_027215954.2","XP_069984616.1",0.653],["XP_027215954.2","XP_069989753.1",0.867],["XP_027221302.2","XP_027215738.1",0.737],["XP_027221302.2","XP_027216222.1",0.922],["XP_027221302.2","XP_027222686.1",0.831],["XP_027221302.2","XP_027228873.2",0.846],["XP_027221302.2","XP_069974807.1",0.504],["XP_027221302.2","XP_069974812.1",0.938],["XP_027221302.2","XP_069971522.1",0.531],["XP_027221302.2","XP_027232512.1",0.87],["XP_027221302.2","XP_069987722.1",0.943],["XP_027221302.2","XP_069984616.1",0.914],["XP_027221302.2","XP_069989753.1",0.763],["XP_027222686.1","XP_027211098.2",0.981],["XP_027222686.1","XP_027216222.1",0.982],["XP_027222686.1","XP_027228873.2",0.688],["XP_027222686.1","XP_069974807.1",0.989],["XP_027222686.1","XP_069974812.1",0.976],["XP_027222686.1","XP_069971522.1",0.96],["XP_027222686.1","XP_027233390.2",0.986],["XP_027222686.1","XP_027232512.1",0.861],["XP_027222686.1","XP_069987722.1",0.964],["XP_027222686.1","XP_069984616.1",0.99],["XP_027222686.1","XP_069989753.1",0.985],["XP_069989753.1","XP_027232512.1",0.94],["XP_069989753.1","XP_027233390.2",0.73],["XP_069989753.1","XP_069971522.1",0.873],["XP_069989753.1","XP_069974807.1",0.848],["XP_069989753.1","XP_069974812.1",0.957],["XP_069989753.1","XP_069984616.1",0.942],["XP_069989753.1","XP_069987722.1",0.896],["XP_069989753.1","XP_027211098.2",0.96],["XP_069989753.1","XP_027215738.1",0.956],["XP_069989753.1","XP_027216222.1",0.943],["XP_069989753.1","XP_027228873.2",0.931],["XP_027233390.2","XP_027211098.2",0.878],["XP_027233390.2","XP_027215738.1",0.935],["XP_027233390.2","XP_027216222.1",0.937],["XP_027233390.2","XP_027228873.2",0.923],["XP_027233390.2","XP_027232512.1",0.956],["XP_027233390.2","XP_069974807.1",0.76],["XP_027233390.2","XP_069974812.1",0.926],["XP_027233390.2","XP_069971522.1",0.815],["XP_027233390.2","XP_069987722.1",0.873],["XP_027233390.2","XP_069984616.1",0.941],["XP_069971522.1","XP_069984616.1",0.972],["XP_069971522.1","XP_069987722.1",0.928],["XP_069971522.1","XP_027211098.2",0.962],["XP_069971522.1","XP_027215738.1",0.908],["XP_069971522.1","XP_027216222.1",0.979],["XP_069971522.1","XP_027228873.2",0.92],["XP_069971522.1","XP_027232512.1",0.938],["XP_069971522.1","XP_069974807.1",0.905],["XP_069971522.1","XP_069974812.1",0.976],["XP_027216222.1","XP_027211098.2",0.932],["XP_027216222.1","XP_027228873.2",0.906],["XP_027216222.1","XP_027215738.1",0.957],["XP_027216222.1","XP_069974807.1",0.951],["XP_027216222.1","XP_069974812.1",0.97],["XP_027216222.1","XP_027232512.1",0.954],["XP_027216222.1","XP_069987722.1",0.959],["XP_027216222.1","XP_069984616.1",0.983],["XP_027228873.2","XP_027211098.2",0.889],["XP_027228873.2","XP_027215738.1",0.901],["XP_027228873.2","XP_027232512.1",0.724],["XP_027228873.2","XP_069974807.1",0.874],["XP_027228873.2","XP_069974812.1",0.94],["XP_027228873.2","XP_069984616.1",0.943],["XP_027228873.2","XP_069987722.1",0.865],["XP_069974812.1","XP_069987722.1",0.963],["XP_069974812.1","XP_069984616.1",0.969],["XP_069974812.1","XP_027211098.2",0.954],["XP_069974812.1","XP_027215738.1",0.949],["XP_069974812.1","XP_027232512.1",0.956],["XP_069974812.1","XP_069974807.1",0.968],["XP_069987722.1","XP_069974807.1",0.908],["XP_069987722.1","XP_069984616.1",0.958],["XP_069987722.1","XP_027211098.2",0.945],["XP_069987722.1","XP_027215738.1",0.924],["XP_069987722.1","XP_027232512.1",0.97],["XP_069984616.1","XP_069974807.1",0.95],["XP_069984616.1","XP_027211098.2",0.973],["XP_069984616.1","XP_027215738.1",0.979],["XP_069984616.1","XP_027232512.1",0.982],["XP_027215738.1","XP_027211098.2",0.964],["XP_027215738.1","XP_069974807.1",0.673],["XP_027215738.1","XP_027232512.1",0.959],["XP_027211098.2","XP_069974807.1",0.921],["XP_027211098.2","XP_027232512.1",0.986],["XP_069974807.1","XP_027232512.1",0.975]],"all_go_terms":{"GO:0002227":6,"GO:0006997":6,"GO:0007549":6,"GO:0070481":6,"GO:0043486":3,"GO:0006335":6,"GO:0000183":6,"GO:0031508":6,"GO:1904693":6,"GO:0006357":3,"GO:0001649":6,"GO:0051572":6,"GO:0007286":6,"GO:0008584":6,"GO:0061641":6,"GO:0034184":6,"GO:0090230":6,"GO:0000122":7,"GO:0030543":6,"GO:0007420":6,"GO:0033128":6,"GO:0045618":6,"GO:0006334":4,"GO:0019731":6,"GO:0007296":6,"GO:0035023":6,"GO:2000973":6,"GO:0061086":6,"GO:0031639":6,"GO:1901837":6,"GO:0008285":3,"GO:0007338":6,"GO:1902340":6,"GO:0071169":7,"GO:0050830":6,"GO:0051290":6,"GO:0003344":6,"GO:0003209":6,"GO:1904815":6,"GO:0035093":6,"GO:0030466":6,"GO:0071392":3,"GO:0045815":6,"GO:0048477":6,"GO:0042692":6,"GO:0031509":6,"GO:0035264":6,"GO:0071674":6,"GO:0007283":6,"GO:0021549":1,"GO:0021591":1,"GO:0048132":1,"GO:0090309":1,"GO:0016358":1,"GO:0001964":1,"GO:0019230":1,"GO:0042551":1,"GO:0001662":1,"GO:1900114":1,"GO:0008211":1,"GO:0042711":1,"GO:0007585":1,"GO:0050432":1,"GO:0051151":1,"GO:2000820":1,"GO:0060079":1,"GO:0002087":1,"GO:0044026":1,"GO:0031061":1,"GO:0006349":1,"GO:0051567":1,"GO:0006346":1,"GO:0001976":1,"GO:0072325":1,"GO:0035067":1,"GO:0045898":5,"GO:0043457":5,"GO:1900446":5,"GO:2000306":5,"GO:0000436":5,"GO:0043966":5,"GO:0042766":5,"GO:0061408":5,"GO:1902455":1,"GO:0006412":2,"GO:0000027":1,"GO:0046632":1,"GO:0002181":1,"GO:0007093":1,"GO:0002309":1,"GO:0033077":1,"GO:0007369":1,"GO:0031167":1,"GO:0048821":1,"GO:0022605":1,"GO:0042254":1,"GO:0001890":1,"GO:0006924":1,"GO:0031929":1,"GO:0043065":1,"GO:0042274":1,"GO:0000462":1,"GO:0000082":1,"GO:0097298":1,"GO:0098532":1,"GO:0070828":1,"GO:0080182":1,"GO:0016584":1},"recipe_readded":[]}