[{"hash":"1502841369940150345","title":"Muscle Chromatin Regulation and Sarcomere Organization","description":"This cluster is dominated by terms related to muscle biology (skeletal muscle fiber adaptation and sarcomere organization) and gene expression control (positive regulation of gene expression, histone-related modifications), suggesting a group of proteins involved in chromatin remodeling linked to muscle structure and regulatory processes. While a few terms point to broader chromatin maintenance in other tissues (e.g., retina homeostasis, subtelomeric heterochromatin formation), the strong muscle-centric signals indicate a coherent theme centered on chromatin regulation impacting muscle fiber organization and adaptation.","confidence":"High","size":29,"edges":112,"triangles":261,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":17},{"id":"GO:0043503","count":11},{"id":"GO:0010628","count":9},{"id":"GO:0051654","count":9},{"id":"GO:0030100","count":9}]},{"hash":"1759941357512753508","title":"Sex steroid biosynthesis and gonadal development","description":"The cluster\u2019s strongest signals come from GO terms for androgen and testosterone biosynthesis and female gonad development, pointing to a core role in sex steroid production and gonadal differentiation. Additional terms indicate broader developmental regulation, transcription control, and some neural/renal development, but the dominant theme appears to be steroidogenesis linked to gonadal development. The antibiotic biosynthetic process term seems likely noise. ","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":5},{"id":"GO:0006355","count":5},{"id":"GO:0008585","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0008209","count":5}]},{"hash":"455764008626214330","title":"Vertebrate organogenesis and vascular development","description":"The top GO terms indicate involvement in the development of multiple organ systems (skeletal, ovarian follicle, heart/right atrium, venous endothelium) and related vascular differentiation, with supporting signals like hypoxia response and inflammatory mediator production that can accompany remodeling. The presence of metabolic and a few outlier terms (e.g., chitin catabolic process) suggests some annotation noise, but the dominant pattern points to organogenesis and vascular development as the core theme of this cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0001501","count":4},{"id":"GO:2000354","count":3},{"id":"GO:0097211","count":3},{"id":"GO:0006032","count":3},{"id":"GO:0002532","count":3}]},{"hash":"246152844408669695","title":"Calcium-Driven Stress Response and Development Signaling","description":"This cluster is enriched for cellular responses to calcium ions, xenobiotic stimuli, hypoxia, and microautophagy, with additional terms tied to memory and heart development. Together these terms imply a calcium-driven signaling network coordinating stress responses and developmental processes, justifying a label around calcium-mediated stress signaling with developmental aspects.","confidence":"High","size":29,"edges":83,"triangles":114,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071277","count":14},{"id":"GO:0035690","count":14},{"id":"GO:0043950","count":11},{"id":"GO:0016237","count":11},{"id":"GO:0007614","count":11}]},{"hash":"1459610429294382932","title":"Embryonic organogenesis and neural development","description":"The cluster centers on developmental processes across multiple organ systems, especially heart (heart and pulmonary myocardium development), nervous system (CNS development, neuron migration, myelination), and skeletal formation (cranial skeleton morphogenesis, organ induction), indicating a cohesive embryonic organogenesis theme.","confidence":"High","size":29,"edges":9,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":13},{"id":"GO:0007275","count":13},{"id":"GO:0003350","count":13},{"id":"GO:0001764","count":13},{"id":"GO:0001759","count":13}]},{"hash":"1263875107251669627","title":"Embryonic neural patterning and organogenesis","description":"This cluster shows strong neural development signals (neuron migration, interneuron specification, forebrain regionalization) and organogenesis signals (kidney and pancreas development). The common thread appears to be embryonic development and patterning across tissues, likely coordinated by signaling pathways such as NFAT/NF-kB and cytoskeletal regulation.","confidence":"Medium","size":29,"edges":38,"triangles":2,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097477","count":6},{"id":"GO:0008588","count":5},{"id":"GO:0030835","count":5},{"id":"GO:0035849","count":5},{"id":"GO:0021521","count":5}]},{"hash":"2276669277779110471","title":"Membrane transporters for ions and nutrients","description":"This cluster is strongly characterized by transmembrane transport GO terms (sodium and potassium ions, nitrates/nitrite, galactose, vitamins, xenobiotics) and includes a vesicular neurotransmitter loading term, indicating a core theme of membrane transporter proteins across diverse substrates.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0015757","count":3}]},{"hash":"339849997117361958","title":"ER stress and unfolded protein response","description":"Based on enriched terms such as protein folding in the endoplasmic reticulum, response to unfolded protein, cellular response to oxidative stress, and redox homeostasis, the cluster centers on ER quality control and the unfolded protein response, with transcriptional changes likely accompanying stress. The combination of ER folding and oxidative stress signals makes ER stress and UPR the best unifying label.","confidence":"High","size":29,"edges":80,"triangles":116,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":14},{"id":"GO:0034975","count":13},{"id":"GO:0045454","count":12},{"id":"GO:0070301","count":10},{"id":"GO:0070389","count":10}]},{"hash":"466874393815629669","title":"Insect Molting and Neural Development","description":"The cluster\u2019s top GO terms center on insect-specific processes like molting and cuticle formation (molting cycle, larval cuticle development) together with neural development concepts (synapse maturation, regulation of synaptic plasticity) and broad developmental roles (embryonic organ development, fertilization). This combination points to a group of proteins involved in developmental programs in insects, linking exoskeleton formation to neural maturation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":4},{"id":"GO:0048168","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0045944","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1499691774037022145","title":"Metabolic Regulation and Protein Synthesis","description":"The cluster shows a mix of metabolic and gene-expression related GO terms (translation, thyroid hormone metabolism, digestion, response to starvation, and transcription regulation) along with energy production (mitochondrial electron transport) and signaling (protein dephosphorylation). This pattern suggests a broad theme around cellular energy management and protein turnover rather than a single narrow function.","confidence":"Medium","size":29,"edges":358,"triangles":2897,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0042594","count":2},{"id":"GO:0060315","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0014850","count":2}]},{"hash":"163161720557558518","title":"Neural development and ERK/MAPK signaling","description":"The cluster shows strong enrichment for nervous system development, hippocampus development, and dendrite morphogenesis, with guiding signaling through ERK/MAPK (ERK1/2 cascade) and related phosphorylation processes. A single immune pathway term appears looser, but does not define the group, so the core theme is neural development linked to MAPK signaling.","confidence":"High","size":29,"edges":14,"triangles":0,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":10},{"id":"GO:0033138","count":9},{"id":"GO:0000186","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0070374","count":9}]},{"hash":"929460458511495343","title":"Sterol and lipid biosynthesis","description":"The top GO terms cluster around sterol and lipid metabolism, including sterol oxidation steps, cholesterol biosynthesis via lathosterol, ergosterol biosynthesis, and ether lipid/fatty acid biosynthesis. The inclusion of CNS myelin maintenance and sebaceous gland differentiation supports a theme tied to lipid membranes and lipid homeostasis, which aligns with sterol biosynthesis and broader lipid metabolic processes. Overall, these proteins appear connected by a shared function in sterol and lipid production and metabolism. ","confidence":"High","size":29,"edges":3,"triangles":0,"max_degree":2,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0035754","count":9},{"id":"GO:0032286","count":9},{"id":"GO:0080065","count":9},{"id":"GO:0080064","count":9},{"id":"GO:0033490","count":9}]},{"hash":"495065146101424352","title":"Cardiac development and calcium signaling","description":"The top GO terms cluster around heart function and calcium handling, including regulation of SA node action potential, ryanodine receptor calcium release, and stress-induced cardiac hypertrophy, pointing to a core theme of cardiac electrophysiology and development; other terms reflect broader developmental processes but do not outweigh the cardiac signal.","confidence":"Medium","size":29,"edges":56,"triangles":27,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098907","count":9},{"id":"GO:0007205","count":8},{"id":"GO:0072205","count":8},{"id":"GO:0042994","count":8},{"id":"GO:1903244","count":7}]},{"hash":"1810703128412977991","title":"ER-Golgi trafficking and Golgi organization","description":"Proteins in this cluster are enriched for processes related to vesicle transport within the secretory pathway, especially ER-to-Golgi and Golgi-to-ER transport, and Golgi organization, pointing to a cohesive role in maintaining Golgi function and vesicular trafficking. The cyto/vacuolar targeting term (Cvt) also aligns with cytoplasmic vesicle targeting, supporting a trafficking-centric theme; auxiliary terms such as filopodium assembly and sprouting angiogenesis may reflect broader cytoskeletal remodeling associated with membrane traffic. Overall, the core signal is secretory pathway and Golgi apparatus maintenance.","confidence":"Medium","size":29,"edges":7,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032258","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0007030","count":7},{"id":"GO:0006890","count":7},{"id":"GO:0006888","count":7}]},{"hash":"428016799958597358","title":"ER Stress and Protein Quality Control","description":"The top GO terms cluster around unfolded protein response, ER-associated degradation, protein folding in the endoplasmic reticulum, and post-translational targeting/trafficking related to ER processes, all pointing to ER proteostasis and quality control. Some outliers (mesoderm formation, nuclear export regulation) are less directly tied but do not override the dominant ER-centric theme.","confidence":"Medium","size":29,"edges":74,"triangles":94,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0006986","count":4},{"id":"GO:0071374","count":4},{"id":"GO:0036494","count":4},{"id":"GO:0001707","count":4}]},{"hash":"1736513118425597841","title":"Neuronal signaling and development","description":"Dominant GO terms point to neural signaling and brain development, with emphasis on ERK/MAPK cascades, Wnt signaling, synaptic activity (excitatory postsynaptic potential), dopamine response, and hippocampus development. While a T cell receptor signaling term appears, the overall pattern is strongly suggestive of proteins involved in neuronal signal transduction and neurodevelopment.","confidence":"High","size":29,"edges":56,"triangles":27,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":27},{"id":"GO:0000186","count":27},{"id":"GO:0090263","count":27},{"id":"GO:0050852","count":27},{"id":"GO:1903351","count":27}]},{"hash":"679083307084393306","title":"Chitin catabolic and inflammatory signaling","description":"The strongest terms point to chitin catabolic process and production of inflammatory mediators/chemokines, suggesting a theme where chitin metabolism is linked to inflammatory signaling. Carbohydrate metabolic process supports the metabolic aspect, while the additional terms (ion transport, receptor internalization, and development-related terms) reflect broader signaling and developmental roles that accompany these core functions. Overall, the cluster seems to center on chitin-related remodeling intertwined with immune signaling, with some auxiliary membrane and developmental processes.","confidence":"Medium","size":29,"edges":74,"triangles":79,"max_degree":14,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":10},{"id":"GO:0002532","count":10},{"id":"GO:0090197","count":10},{"id":"GO:0005975","count":10},{"id":"GO:0035725","count":3}]},{"hash":"929237856619370237","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":403,"triangles":3574,"max_degree":28,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":19},{"id":"GO:0000462","count":5},{"id":"GO:0006413","count":5},{"id":"GO:0009636","count":5},{"id":"GO:0097049","count":5}]},{"hash":"152717367101885913","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":2},{"id":"GO:0061087","count":2},{"id":"GO:0008277","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0071049","count":1}]},{"hash":"366878635741026438","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0098735","count":5},{"id":"GO:0006508","count":5}]},{"hash":"2192480266108675612","title":"Retinoid metabolism and neural development","description":"Enriched terms include retinol metabolic process and retinoic acid biosynthetic process (3 counts each), pointing to retinoid signaling. Coupled terms such as startle response and prepulse inhibition indicate neural/behavioral relevance, aligning with retinoids' roles in neural development and function. Additional terms touch on lipid metabolism and gut epithelium maintenance, but the strongest common thread is retinoid metabolism affecting neural development and behavior.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":3},{"id":"GO:0001964","count":3},{"id":"GO:0060134","count":3},{"id":"GO:0002138","count":3},{"id":"GO:0045471","count":3}]},{"hash":"1324950976330607107","title":"Neural development and membrane transport","description":"The cluster shows enrichment for neuron development and sensory perception (including hearing and eye/lens development), alongside multiple transmembrane transport terms (chloride, glucose, amino acids, L-cystine). This points to proteins involved in neural/sensory tissue development that function as membrane transporters, connecting development with substance transport across membranes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048666","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0050910","count":3},{"id":"GO:1902476","count":3},{"id":"GO:1904659","count":2}]},{"hash":"1670501415027975722","title":"Adrenergic GPCR\u2013cAMP signaling and blood pressure regulation","description":"This cluster is dominated by GO terms tied to adrenergic receptor signaling that couples to adenylate cyclase and cAMP pathways, including activation of adenylate cyclase, norepinephrine/epinephrine\u2013mediated vasoconstriction, and positive regulation of blood pressure. While there are additional terms related to xenobiotic response, inflammation, and even mitochondrial electron transport, the strongest and most frequent signals point to GPCR-mediated signaling controlling vascular tone and blood pressure. Confidence reflects this clear, core theme with some peripheral processes present.","confidence":"High","size":29,"edges":42,"triangles":2,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":21},{"id":"GO:0007190","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0045777","count":21},{"id":"GO:0042493","count":21}]},{"hash":"494560184473415468","title":"GTPase-regulated lamellipodium formation and cell spreading","description":"Based on the top GO terms, the cluster is enriched for Rho family GTPase signaling (Rho/Rac), small GTPase-mediated signal transduction, Rac regulation, and lamellipodium assembly, all pointing to actin cytoskeleton remodeling and cell motility. While bone and heart development terms appear, the dominant theme is cytoskeletal dynamics driven by GTPase signaling and associated cell spreading. The other terms may reflect pleiotropic roles of these proteins rather than a single pathway. ","confidence":"Medium","size":29,"edges":5,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060348","count":15},{"id":"GO:0007507","count":14},{"id":"GO:0035023","count":14},{"id":"GO:0007264","count":14},{"id":"GO:0008286","count":14}]},{"hash":"422422362420096334","title":"Cytoskeleton remodeling and morphogenesis","description":"The top GO terms cluster around cytoskeletal dynamics and cell-shape changes, including filopodium and dendritic spine morphogenesis, mitotic spindle assembly, and regulation of cell migration in sprouting angiogenesis, all of which point to actin/microtubule\u2013driven remodeling and morphogenesis. Additional terms invoking phosphatidylinositol biosynthesis further tie into signaling that governs cytoskeletal organization. Some terms appear organism- or context-specific (mating projection, sorocarp development), but they still reflect broader morphogenetic processes. ","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0031384","count":1},{"id":"GO:0061383","count":1}]},{"hash":"184262448771303746","title":"Membrane Transporters (ions and small molecules)","description":"Based on the GO terms, the cluster is dominated by transmembrane transport activities for a variety of substrates (potassium and sodium ions, nitrite, xenobiotics, sugars like arabinose and galactose, fucose metabolism, and neurotransmitter loading). The common thread is membrane transport proteins that shuttle small molecules and ions across membranes, indicating a transporter-focused cluster rather than a single-substrate function.","confidence":"High","size":29,"edges":33,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":8},{"id":"GO:0035725","count":5},{"id":"GO:0006855","count":4},{"id":"GO:0015707","count":4},{"id":"GO:0098700","count":4}]},{"hash":"1838868348125155598","title":"Mitosis-Linked Apoptosis and Innate Immunity","description":"The cluster shows strong representation of mitotic spindle assembly, apoptotic processes (including pyroptosis) and innate immune response, plus protein ubiquitination, indicating a group of proteins that couple cell division with immune and cell death signaling. Additional signaling-related terms (Rho, phosphatidylinositol) point to broader signal transduction roles, while a plant hormone pathway annotation appears among weaker terms. Overall, the dominant theme is coordination of the cell cycle with programmed cell death and innate immunity.","confidence":"Medium","size":29,"edges":35,"triangles":19,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090307","count":14},{"id":"GO:0045087","count":14},{"id":"GO:0016567","count":14},{"id":"GO:1990001","count":14},{"id":"GO:0070269","count":14}]},{"hash":"2229658560239230179","title":"Transmembrane transporters for sugars and xenobiotics","description":"The top GO terms point to a broad set of membrane transport activities, including xenobiotic, vitamin, and sugar (fructose, glucose, xylose, trehalose) transport, indicating a cluster of transporter proteins facilitating uptake/efflux of diverse small molecules across membranes.","confidence":"High","size":29,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":28},{"id":"GO:0035461","count":28},{"id":"GO:0042891","count":27},{"id":"GO:0042908","count":27},{"id":"GO:1990539","count":26}]},{"hash":"405646257123443907","title":"Neuronal Synaptic Transmission and Plasticity","description":"Most terms point to neuronal communication and plasticity: regulation and enhancement of synaptic transmission (long- and short-term), glutamatergic signaling, long-term memory, neuromuscular transmission, and cerebellar granule cell differentiation. A few items relate to sensory system development (lateral line) or fungicide response, but they are minority. Overall, the cluster seems to group proteins involved in synaptic signaling and plasticity in neurons.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":4},{"id":"GO:0050806","count":3},{"id":"GO:0048915","count":3},{"id":"GO:0048899","count":3},{"id":"GO:0048172","count":3}]},{"hash":"192726099568323991","title":"Embryonic Development and Morphogenesis","description":"Based on GO terms centered on embryogenesis and tissue formation (left-right patterning, placental and trophoblast differentiation, cartilage morphogenesis, EMT in heart, and pancreatic endocrine development), the proteins appear to be involved in embryonic development and organ morphogenesis. A splice site recognition term is present but does not define the cluster\u2019s core function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":1},{"id":"GO:0045843","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060707","count":1}]},{"hash":"1508803360032217412","title":"Neurodevelopment and skeletal development","description":"This cluster centers on developmental processes spanning nervous system formation (axon guidance, neuron projection development, nervous system development) and skeletal/ocular differentiation (lens fiber differentiation, skeletal system development, ossification). The presence of Hedgehog signaling (Smoothened) and related processes suggests developmental signaling in multiple tissues, with a mix of neural and skeletal themes rather than a single pathway. The lack of network edges indicates these proteins may be functionally diverse but share broad developmental annotations.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070306","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0031175","count":5},{"id":"GO:0043552","count":5}]},{"hash":"1003151879474967671","title":"Developmental signaling and organogenesis","description":"The top GO terms cluster around broad developmental processes across multiple tissues (nervous system, kidney, megakaryocytes) and signaling pathways (Smoothened/Hedgehog), plus angiogenesis and general multicellular development. This suggests a cohesive theme of developmental regulation and organogenesis rather than a single, specific function, despite some noise from obsolete terms.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0035584","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0007417","count":3}]},{"hash":"1675081168267810114","title":"SNARE-Mediated Golgi-to-Plasma Membrane Trafficking","description":"This cluster is dominated by GO terms for ER-to-Golgi and intra-Golgi transport, Golgi ribbon formation, SNARE complex assembly, and exocytic insertion of neurotransmitter receptors to the postsynaptic membrane, with supporting retrograde transport and protein localization to the plasma membrane. Together these indicate a cohesive role in Golgi-based vesicle trafficking and SNARE-driven delivery of receptors to the plasma membrane, relevant to synaptic function and plasticity.","confidence":"High","size":29,"edges":80,"triangles":59,"max_degree":12,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0006888","count":14},{"id":"GO:0048280","count":12},{"id":"GO:0006891","count":12},{"id":"GO:0090161","count":12},{"id":"GO:0060291","count":11}]},{"hash":"509030637318230181","title":"Unknown","description":"The top GO terms span hepatocyte apoptosis, insulin- and vitamin D\u2013related responses, adipogenesis, muscle stretch response, cell migration, mRNA processing, and telomere maintenance/capping, with no single coherent function dominating. The cluster appears to link multiple unrelated processes rather than a unified biological theme, so a specific label isn\u2019t justifiable.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0032212","count":5},{"id":"GO:0033280","count":5},{"id":"GO:0016477","count":5}]},{"hash":"188030686775920094","title":"Adrenergic GPCR-cAMP signaling and vascular regulation","description":"This cluster centers on GO terms for adenylate cyclase-activating GPCR signaling, activation of adenylate cyclase, and cAMP-mediated pathways, including norepinephrine/epinephrine-driven vasoconstriction and blood pressure regulation. The presence of inflammatory response and dendritic cell differentiation terms suggests immune modulation linked to GPCR/cAMP signaling, while electron transport chain terms point to a metabolic context. Overall, the dominant theme is adrenergic GPCR signaling controlling vascular tone, with supporting metabolic and immune-related processes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":27},{"id":"GO:0022900","count":27},{"id":"GO:0045777","count":27},{"id":"GO:0007190","count":25},{"id":"GO:0043950","count":22}]},{"hash":"1614661737102003609","title":"GABAergic Synapses and Sensory Neuron Development","description":"This cluster is dominated by terms related to GABA signaling and inhibitory synaptic function (GABA receptor clustering, inhibitory postsynaptic potential, chloride transport) and sensory system development (optic nerve morphogenesis, inner ear receptor cell development), pointing to a theme of neural communication and sensory neuron maturation. A couple of terms are peripheral annotations, but the core pattern supports a GABAergic synapse and sensory neuron development label.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":6},{"id":"GO:0017085","count":6},{"id":"GO:0051971","count":6},{"id":"GO:2001226","count":5},{"id":"GO:0021631","count":5}]},{"hash":"1481220115243745588","title":"Neural signaling and sensory development","description":"Terms indicate roles in neural communication (synaptic transmission, plasticity, and glutamatergic regulation) alongside sensory development and learning (lateral line development, conditioned taste aversion, dorsal axis patterning). The cluster seems to group proteins connected to neural signaling with sensory patterning/learning processes, though some terms are peripheral. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":3},{"id":"GO:2000053","count":2},{"id":"GO:0048263","count":2},{"id":"GO:0061178","count":2},{"id":"GO:0050806","count":2}]},{"hash":"857154698917391556","title":"Developmental growth and cell cycle regulation","description":"The top GO terms cluster around transcriptional control, ribosome biogenesis, TORC1 signaling, and mitotic cell cycle processes, all of which underpin cellular growth and organismal development. Additional terms like multicellular growth and skin development support a developmental/regulatory theme, while fertilization and defense terms may reflect contextual roles or pleiotropy. Overall, the cluster appears to group genes involved in developmental growth and proliferation rather than a single narrow function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0007338","count":6},{"id":"GO:0035264","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0000747","count":5}]},{"hash":"702091403616990851","title":"Transposable elements and proviral integration","description":"The top GO terms point to DNA integration/transposition, retrotransposition, and proviral latency, indicating proteins tied to mobile genetic elements and viral genome integration rather than regular host processes.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0006313","count":4},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0046718","count":3}]},{"hash":"109015755268491220","title":"Small-molecule metabolism and detoxification","description":"Based on the top GO terms, these proteins are involved in biosynthesis of vitamins and secondary metabolites (e.g., biotin biosynthesis, antibiotic biosynthesis, alkaloid metabolism) as well as multiple catabolic and detoxification processes (oxidant detoxification, prostaglandin and glucuronoside catabolic processes, various oxidation-reduction and xenobiotic-related reactions). This suggests a shared theme of enzymatic transformation of small molecules, encompassing both synthesis and detoxification, rather than a single, tight pathway. ","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0009636","count":6},{"id":"GO:0009102","count":6},{"id":"GO:0098869","count":6},{"id":"GO:0055114","count":6}]},{"hash":"707496759253552074","title":"Developmental transcription regulation","description":"This cluster centers on transcriptional control by RNA polymerase II (including negative regulation) and is enriched for a broad set of embryonic development processes (midbrain, eye morphogenesis, heart, limb, streak formation, glial differentiation). The common theme is regulation of gene expression during development across multiple tissues, making this label representative.","confidence":"High","size":28,"edges":11,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0007275","count":7},{"id":"GO:0006366","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0048048","count":7}]},{"hash":"706569892506538664","title":"Embryogenesis and endocrine organogenesis","description":"The cluster is enriched for embryonic development and organ formation terms, including placenta/trophoblast differentiation, left-right patterning, EMT in cardiac cushion formation, cartilage morphogenesis, and pancreatic cell development, along with endocrine system development. The presence of transcription-related terms (DNA-templated transcription, negative regulation of transcription by RNA polymerase II) suggests coordinated transcriptional control during these developmental processes, supporting a coherent theme of embryogenesis and endocrine organogenesis.","confidence":"Medium","size":28,"edges":30,"triangles":0,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0060972","count":5}]},{"hash":"1130986740645401941","title":"Lectin pathway\u2013driven inflammation and ECM remodeling","description":"The cluster is dominated by GO terms for lectin pathway complement activation, leukocyte tethering/rolling, and response to lipopolysaccharide, indicating innate immune activation. Coupled with extracellular matrix disassembly and positive regulation of blood coagulation, the overall theme is inflammation linked to tissue remodeling and hemostasis. A few terms related to development and transcription regulation appear as noise but do not define the core function.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001867","count":10},{"id":"GO:0022617","count":6},{"id":"GO:0050901","count":6},{"id":"GO:0032496","count":5},{"id":"GO:0055114","count":5}]},{"hash":"126429956033438806","title":"Embryonic development and neural patterning","description":"This cluster centers on broad developmental processes and neural development, with GO terms for multicellular organism development, neural crest cell migration, axon guidance, neuron differentiation, and BMP/FGF signaling regulation. The mix of organismal development and neural-specific terms suggests roles in embryonic patterning and neural differentiation across species, even though the proteins come from diverse contexts (including insect imaginal disc morphogenesis). ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0060484","count":3},{"id":"GO:0090272","count":3},{"id":"GO:0030513","count":2},{"id":"GO:0048803","count":2}]},{"hash":"2183682335155140044","title":"Interferon-driven innate antiviral response","description":"The cluster is dominated by GO terms related to innate immunity, including cellular response to exogenous dsRNA, innate immune response, and cellular response to type I interferon, indicating antiviral defense via interferon signaling. Developmental terms (striatum development, prostate gland development, sex differentiation) may reflect multifunctional proteins or annotation noise, but the prevailing theme is antiviral innate immunity.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0071360","count":8},{"id":"GO:0050689","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0071357","count":8}]},{"hash":"518648910574846074","title":"Ubiquitin-Proteasome\u2013Mediated Cell Cycle Proteolysis","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein degradation (SCF, APC/C, ERAD) and cell division, pointing to proteolysis-driven regulation of the cell cycle as the core theme. Additional terms touch on neuronal development and organelle inheritance, which may reflect broader cellular maintenance roles but do not outweigh the proteolysis-centric pattern.","confidence":"Medium","size":28,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0030433","count":2}]},{"hash":"1945189549870602269","title":"ER Stress and Protein Folding","description":"This cluster is dominated by GO terms for unfolded protein response, ER stress-related translation initiation, and protein folding/isomerization, suggesting a coherent theme around ER stress signaling and chaperone-assisted folding.","confidence":"High","size":28,"edges":7,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051291","count":6},{"id":"GO:0043278","count":6},{"id":"GO:0005978","count":5},{"id":"GO:0071360","count":5},{"id":"GO:0007091","count":5}]},{"hash":"229088243209658787","title":"Larval chitin-based cuticle development","description":"The dominant GO term is larval chitin-based cuticle development (23 proteins), indicating a cohesive module for larval cuticle formation. Other terms point to ER protein folding and stress responses, suggesting these proteins are secreted or processed in the ER as part of cuticle biosynthesis. Overall, a focused theme on larval cuticle formation with related secretory/ER quality-control processes.","confidence":"High","size":28,"edges":216,"triangles":841,"max_degree":25,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008363","count":23},{"id":"GO:0006986","count":4},{"id":"GO:0036494","count":4},{"id":"GO:0070389","count":4},{"id":"GO:0071374","count":3}]},{"hash":"682300447858283099","title":"Insect development and cell cycle","description":"This cluster is enriched for developmental processes (body morphogenesis, chitin-based cuticle development) together with core cell cycle functions (mitotic cell cycle, cell division). The co-occurrence of these terms suggests proteins involved in organismal growth and proliferation, likely with insect-specific context given the cuticle term; additional neural signaling and immune/stress terms may reflect broader roles but do not override the dominant developmental-cell cycle theme.","confidence":"Medium","size":28,"edges":88,"triangles":167,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0040003","count":3},{"id":"GO:0010171","count":3},{"id":"GO:0051291","count":2}]},{"hash":"1057137056366950477","title":"RNA Processing and Ribosome Biogenesis","description":"The terms point to RNA maturation and assembly of ribonucleoprotein complexes: spliceosome pre-catalytic assembly, preribosome assembly, and rRNA processing, with related RNA processing activities like polyadenylation. Together they suggest a cohesive role in ribosome biogenesis and RNA maturation, with a few stress-response terms that may reflect cellular contexts rather than core function.","confidence":"High","size":28,"edges":6,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000354","count":1},{"id":"GO:0034463","count":1},{"id":"GO:0000464","count":1},{"id":"GO:1903220","count":1},{"id":"GO:0098789","count":1}]},{"hash":"1476694819970477248","title":"Blood coagulation and vasoconstriction","description":"The top GO terms include blood coagulation, fibrin clot formation, and positive regulation of vasoconstriction, which point to a vascular/coagulation-related theme. Other terms (transcription-related and signaling) appear sparsely and don\u2019t form a cohesive pathway, suggesting annotation noise or multifunction proteins. Therefore the strongest, albeit limited, signal is coagulation/vascular regulation, giving a cautious Low confidence. ","confidence":"Low","size":28,"edges":77,"triangles":72,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0031564","count":1},{"id":"GO:0015976","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0034251","count":1},{"id":"GO:0000160","count":1}]},{"hash":"1631621697416440785","title":"Developmental Morphogenesis and Reproduction","description":"The top GO terms emphasize body plan and tissue development (chitin-based cuticle development, body morphogenesis, muscle and skeletal system development) and reproductive processes (regulation of ovarian follicle development, cellular response to GnRH), suggesting a broad developmental program with reproductive aspects. While there is an immune term and endopeptidase regulation, these appear auxiliary rather than defining, supporting a label centered on developmental morphogenesis with reproductive functions.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":8},{"id":"GO:0010171","count":8},{"id":"GO:0043392","count":2},{"id":"GO:0007620","count":2},{"id":"GO:0048747","count":2}]},{"hash":"891286062236941998","title":"Neural signaling and sensory behavior","description":"Based on GO terms, the cluster is enriched for nervous system functions: sensory perception of sound, innervation, GABA signaling, locomotory behavior, and conditioned taste aversion. These recurrent neural-related annotations suggest the proteins collectively participate in neuronal signaling and behavior, despite a few outlier terms related to reproduction or metabolism that may reflect broader multifunctionality or annotation noise.","confidence":"High","size":28,"edges":27,"triangles":0,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0060384","count":2},{"id":"GO:0007214","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0007340","count":2}]},{"hash":"830748248934983187","title":"Negative Regulation of Developmental Signaling","description":"This cluster is enriched for terms that dampen signaling during development\u2014especially extracellular regulation and Wnt pathway inhibition\u2014along with various developmental processes (forebrain, endoderm, mesoderm, neuromast) and synapse organization. The common theme is modulation rather than activation of signaling pathways in developmental contexts, making this label appropriate.","confidence":"High","size":28,"edges":20,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032091","count":4},{"id":"GO:1900116","count":4},{"id":"GO:0061170","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0001706","count":3}]},{"hash":"160321555769514913","title":"Auditory inner-ear development and GABA signaling","description":"The top GO terms cluster around inner ear development and auditory sensing, including detection of mechanical stimulus in sound, inner ear receptor cell development, and sensory processing. Several entries also relate to GABAergic synaptic function (GABA receptor clustering and inhibitory postsynaptic potentials) and neuronal excitability regulation, which fits with auditory signal processing in the ear. A few terms (optic nerve morphogenesis, ovulation cycle rhythm, chondrocyte morphogenesis) are less related, but the dominant theme is inner-ear development and GABAergic signaling in auditory pathways.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":7},{"id":"GO:2001226","count":6},{"id":"GO:0021631","count":6},{"id":"GO:0060119","count":6},{"id":"GO:0060080","count":6}]},{"hash":"1622871617837743377","title":"Virus-host entry, proviral latency, and host apoptosis","description":"This cluster centers on processes typical of viral infection and host interaction: entry into the host cell, integration of viral genomes, establishment of proviral latency, and modulation of host apoptosis. Additional terms about RNA interference regulation and DNA integration support a theme where host pathways intersect with viral life cycles. Some terms (e.g., symbiont entry, distant DNA processes) may reflect broader host\u2013pathogen interaction contexts or annotation noise, but the strongest signal is virus\u2013host interplay.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0006260","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0015074","count":3}]},{"hash":"1819256827516173203","title":"Unknown","description":"The GO terms span metabolism, neural signaling, circadian rhythm, development, angiogenic signaling, vitamin D response, chitin metabolism, inflammatory mediator production, and oxidative stress response, with no single cohesive function tying them together. The absence of a clear shared pathway or process among these terms suggests the cluster is heterogeneous rather than functionally cohesive. Confidence in a single representative label is therefore None.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":3},{"id":"GO:0007218","count":2},{"id":"GO:0042745","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0048010","count":2}]},{"hash":"1470602323523299094","title":"Pain perception and inflammatory signaling","description":"The top GO terms center on pain-related processes (response to pain, detection of chemical stimulus involved in sensory perception of pain) and inflammatory mediator production (IL-12 regulation, MIP-1 alpha, CXCL1). This points to a cluster of proteins involved in nociception and downstream inflammatory signaling, with additional notes on vasopressin secretion and post-translational modification (poly-ADP-ribosylation) that may modulate signaling. Overall, a cohesive theme is pain response linked to inflammatory mediator production.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":5},{"id":"GO:0086070","count":4},{"id":"GO:0030103","count":4},{"id":"GO:0070212","count":4},{"id":"GO:0050968","count":4}]},{"hash":"1792417030832804500","title":"Immune Signaling and Development","description":"This cluster\u2019s top GO terms span both immune functions (adaptive and innate immune response) and developmental signaling/morphogenesis (ERK cascade regulation, Hedgehog signaling via Smoothened, kidney development, imaginal disc morphogenesis, melanocyte differentiation). The combination suggests a group of proteins involved in signaling crosstalk between immune responses and developmental pathways, with some broader adhesion and catabolic terms as secondary associations. Overall, it points to a theme of immune-related signaling intertwined with developmental processes rather than a single narrow function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0043552","count":2}]},{"hash":"112965364500280107","title":"Purine and Nucleobase Transport","description":"The top GO terms are dominated by membrane transport of purines and related small molecules (guanine, hypoxanthine, xanthine, urate) and taurine, indicating a coherent function of transporting nucleobases and related metabolites across membranes. While a couple terms like brain development and response to antibiotic are less specific, the prevailing pattern supports labeling as purine/nucleobase transport.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0015734","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0035344","count":2}]},{"hash":"2050103445162876189","title":"Auditory sensory development and GABA signaling","description":"This cluster centers on auditory-related sensory development and function (startle response, sound detection, inner ear receptor cell development) together with inhibitory GABAergic signaling (GABA receptor clustering, inhibitory postsynaptic potential) and neuronal ion transport (Ca, K, Cl), suggesting a cohesive theme of auditory sensory processing and its neural inhibition.","confidence":"High","size":28,"edges":20,"triangles":4,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":19},{"id":"GO:0001964","count":18},{"id":"GO:0071805","count":18},{"id":"GO:0045188","count":18},{"id":"GO:0050910","count":18}]},{"hash":"180869046422662285","title":"Paranodal axon junction proteins","description":"The cluster is dominated by GO terms related to paranodal junctions and localization to paranode/juxtaparanode regions of axons, pointing to proteins involved in paranodal axon junction assembly and axon-glial adhesion. Some other terms (e.g., bone development, redox) appear ancillary and not central to the core paranodal theme.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":3},{"id":"GO:0048661","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0060445","count":3},{"id":"GO:0002175","count":3}]},{"hash":"2091709375205389220","title":"Membrane transport and nutrient import","description":"The top GO terms are dominated by membrane transport and uptake processes (xenobiotic transmembrane transport, fructose import, nitrite transport, glucose import in response to insulin, neurotransmitter loading into vesicles, etc.), pointing to a cohesive theme of membrane transporters and metabolite/nutrient import. While a few terms relate to development or signaling, they are less represented, so the main signal is transport/metabolite handling. Confidence: Medium","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0030308","count":2},{"id":"GO:0071773","count":2},{"id":"GO:0006855","count":2},{"id":"GO:1990539","count":2}]},{"hash":"2275015392002417581","title":"Neural signaling via glycine and monoamine transport","description":"This cluster centers on neural functions, showing glial growth/regeneration signals (perineurial glial growth, collateral sprouting) together with neurotransmitter transport and signaling via glycine, dopamine, and serotonin (glycine secretion/import and monoamine uptake). The terms suggest a cohesive theme of neural communication and glial involvement through amino acid and monoamine transport.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042066","count":4},{"id":"GO:0070306","count":3},{"id":"GO:1900016","count":3},{"id":"GO:0048672","count":3},{"id":"GO:0061537","count":3}]},{"hash":"632547577814107602","title":"Actin Filament Dynamics and Sarcomere Organization","description":"The top GO terms cluster around actin cytoskeleton remodeling\u2014depolymerization, severing, and sarcomere organization\u2014indicating a common theme of actin-based dynamics and muscle cell structure, with a few auxiliary terms related to vascular smooth muscle regulation and cell migration.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0051014","count":2},{"id":"GO:1904706","count":2},{"id":"GO:0045214","count":2}]},{"hash":"2304326609609507274","title":"Notch-driven neural development and somitogenesis","description":"The cluster is strongly enriched for developmental processes, especially neural tube patterning and segmentation, as indicated by Notch signaling, floor plate development, and somitogenesis terms. Additional differentiation-related terms (skeletal muscle differentiation, astrocyte differentiation) support a broader developmental/differentiation theme with Notch as a central regulatory axis.","confidence":"High","size":27,"edges":323,"triangles":2531,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0048712","count":9},{"id":"GO:2001038","count":9},{"id":"GO:0055089","count":9},{"id":"GO:0035470","count":9}]},{"hash":"2218229789325490164","title":"Coagulation and Fibrinolysis Regulation","description":"The cluster is dominated by GO terms related to blood coagulation, regulation of fibrinogen levels, plasminogen activation, and fibrinolysis (including Factor XII activation and positive regulation of coagulation), indicating a coherent theme of coagulation cascade control and fibrinolytic processing. A few terms (response to lipopolysaccharide, smooth muscle migration, transcription regulation) may reflect peripheral roles of the same proteins, but the core signal is coagulation/fibrinolysis.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":10},{"id":"GO:0044537","count":9},{"id":"GO:0010756","count":9},{"id":"GO:0051919","count":9},{"id":"GO:0002542","count":9}]},{"hash":"1352934289098969863","title":"Neuronal development and proliferation","description":"The cluster is enriched for neural development and proliferation terms, including substantia nigra development, negative regulation of axonogenesis, cell population proliferation, and cell division, alongside Rab-mediated vesicle signaling and protein heterooligomerization. These together suggest a group of proteins involved in neural growth and circuitry formation with active proliferation and intracellular trafficking, reinforced by associated metabolic processes. ","confidence":"Medium","size":27,"edges":206,"triangles":819,"max_degree":26,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":12},{"id":"GO:0021762","count":10},{"id":"GO:0050771","count":9},{"id":"GO:0032482","count":9},{"id":"GO:0009228","count":8}]},{"hash":"1386228891148341934","title":"Embryonic tissue morphogenesis and organ development","description":"Dominant terms describe tissue and organ development (skeletal muscle development, cartilage morphogenesis, endocrine system and placenta-related development, left-right pattern formation, EMT in endocardial cushion formation). The ubiquitin-dependent protein catabolic process suggests regulation of protein turnover during development. A few terms are unrelated (immune signaling), but the core theme is embryonic tissue morphogenesis.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:2000312","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0007519","count":5},{"id":"GO:0035270","count":4}]},{"hash":"1020038428269029514","title":"Mitotic spindle assembly and microtubule dynamics","description":"This cluster is driven by GO terms describing spindle formation and microtubule behavior during cell division (mitotic spindle assembly/elongation, metaphase chromosome recapture, spindle orientation, and plus-end directed microtubule sliding), indicating proteins involved in mitotic spindle machinery. Some terms seem peripheral (karyogamy, cerebellar structure), but the dominant signal is MT-based spindle dynamics.","confidence":"High","size":27,"edges":140,"triangles":338,"max_degree":26,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":12},{"id":"GO:0033624","count":11},{"id":"GO:1990942","count":11},{"id":"GO:0051296","count":11},{"id":"GO:0000022","count":11}]},{"hash":"1874549359774402328","title":"Embryonic Development and Organogenesis","description":"The top GO terms cluster around broad embryonic development and organogenesis (pancreatic cell and endocrine system development, placental/trophoblast differentiation, left-right patterning, EMT in endocardial cushion formation, cartilage morphogenesis, cerebellar granule cell differentiation, and roof of mouth development), indicating a general developmental program rather than a single pathway.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0035270","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0060972","count":6}]},{"hash":"374189549411303960","title":"Proteostasis and mitochondrial protein quality control","description":"This cluster is enriched for proteostasis-related processes: proteasome regulatory particle assembly, aggresome assembly, autophagosome maturation, cellular response to oxidative stress, and protein import into the mitochondrial intermembrane space. Together these terms point to a network focused on protein quality control, degradation, and organelle stress responses. While some terms (cell division, DNA repair) may reflect additional roles of certain proteins, the dominant theme is proteostasis and stress management.","confidence":"High","size":27,"edges":154,"triangles":414,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0051260","count":6},{"id":"GO:0070682","count":6},{"id":"GO:0006541","count":6},{"id":"GO:0034599","count":5}]},{"hash":"1826899701809372207","title":"Transferrin-Mediated Iron Uptake and Endocytosis","description":"The top GO terms point to iron transport and homeostasis (intracellular iron ion homeostasis, iron import across plasma membrane, transferrin transport) and the uptake mechanism (receptor-mediated endocytosis), suggesting proteins involved in iron acquisition and endocytic trafficking. Some terms about cuticle development and meristem growth are likely secondary annotations, but the dominant pattern supports iron handling via endocytosis.","confidence":"Medium","size":27,"edges":28,"triangles":2,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0006879","count":2},{"id":"GO:0033572","count":2},{"id":"GO:0006898","count":2},{"id":"GO:0017186","count":2}]},{"hash":"1746960811464473159","title":"Vertebrate embryonic organogenesis","description":"The proteins in this cluster are enriched for developmental and morphogenesis processes across multiple organs in vertebrates: retina/eye development, neural crest cell migration, brain segmentation, endocrine pancreas development, ureteric bud morphogenesis, and embryonic digestive tract morphogenesis, among others. This pattern points to a shared role in embryonic organ formation and tissue patterning rather than a single enzymatic activity.","confidence":"High","size":27,"edges":123,"triangles":326,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0002076","count":6},{"id":"GO:0060041","count":6},{"id":"GO:0002087","count":6},{"id":"GO:0035284","count":5}]},{"hash":"1126303600439254153","title":"Embryonic organ development","description":"The cluster shows multiple organ-related development terms (kidney, heart, liver, brain, cochlea, lung) and processes like organ induction and neuron migration, indicating a shared theme of embryonic organogenesis and tissue development across diverse organs.","confidence":"High","size":27,"edges":45,"triangles":11,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0043524","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0090103","count":4},{"id":"GO:0007275","count":4}]},{"hash":"63021324211538126","title":"Vesicle trafficking and mitotic exit","description":"The cluster shows strong enrichment for secretory and endosomal transport (ER-to-Golgi, Golgi-to-ER, protein transport) along with multivesicular body assembly/sorting, and also includes cell-cycle-related terms like exit from mitosis and cell division. This combination points to intracellular vesicle trafficking coordinated with mitotic progression, justifying the label.","confidence":"High","size":27,"edges":50,"triangles":15,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0015031","count":4},{"id":"GO:0006890","count":4}]},{"hash":"1614205460969377117","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitination and proteasome-related processes (ubiquitin-dependent protein catabolic process, polyubiquitination, SCF-dependent proteasomal degradation, ERAD), indicating a cluster centered on tagging proteins for degradation. A few terms touch on unrelated pathways (cadmium response, transcription regulation, DNA damage signaling), but the core signal points to the ubiquitin-proteasome system.","confidence":"High","size":27,"edges":10,"triangles":1,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0030433","count":13},{"id":"GO:0000209","count":10},{"id":"GO:0031146","count":10},{"id":"GO:0051865","count":10}]},{"hash":"1974498690768657674","title":"Post-transcriptional RNA processing and silencing","description":"This cluster centers on post-transcriptional control of gene expression, with strong signals for mRNA splicing (including spliceosome regulation and alternative splicing), polyadenylation, mRNA stability in stress, and RNA silencing pathways (miRNA-mediated and translation inhibition). Obsolete terms reflect historical annotations but converge on the same RNA-processing theme, justifying a cohesive label focused on RNA processing and silencing.","confidence":"High","size":27,"edges":156,"triangles":633,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":11},{"id":"GO:0048026","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0006378","count":10},{"id":"GO:0000381","count":10}]},{"hash":"20923317371872999","title":"Ubiquitin-Dependent Immune Signaling and Apoptosis","description":"This cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, K6-linked ubiquitination) alongside immune signaling and apoptosis regulation (TNF signaling, I-kappaB phosphorylation) and even immune receptor rearrangement (V(D)J recombination). The common thread is ubiquitin-mediated control of immune responses and cell fate, including antiviral transport regulation, suggesting a cohesive theme around ubiquitin-dependent regulation of immunity and apoptosis.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0051865","count":11},{"id":"GO:0042981","count":10},{"id":"GO:1903265","count":10},{"id":"GO:1901253","count":10}]},{"hash":"1364563320354318848","title":"Nuclear import and DNA replication regulation","description":"The GO terms are dominated by nuclear transport processes (NLS-bearing protein import into nucleus, ribosomal protein import into nucleus, nuclear pore complex assembly) and by regulation of DNA replication and centromeric cohesion, indicating a cluster focused on nuclear transport and genome maintenance. Peripheral terms like neutrophil chemotaxis and amino acid response appear less central to this cluster.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0060188","count":5},{"id":"GO:0006610","count":5},{"id":"GO:0000060","count":5}]},{"hash":"673273089532500612","title":"Nuclear transcription and RNA processing","description":"These proteins cluster around core nuclear gene expression functions, including DNA-templated transcription, DNA replication initiation, mRNA splicing via spliceosome, and nuclear export of ribosomal subunits, plus regulation of RNA polymerase II. While cholesterol biosynthesis and visual learning terms appear, the dominant theme is nuclear transcription and RNA processing.","confidence":"High","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0032298","count":5},{"id":"GO:0000055","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0006260","count":4}]},{"hash":"1092820608485119090","title":"Adaptive immune cell differentiation regulation","description":"The top GO terms cluster around regulation and differentiation of adaptive immune cells, notably dendritic cell differentiation, pro-T cell differentiation, memory T cell differentiation, and germinal center formation. This suggests the proteins in this cluster function together in modulating adaptive immune cell development and activation. Some outlier terms (e.g., plant tropisms) likely reflect annotation noise or cross-species annotations, but the dominant theme is immune cell differentiation regulation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:1900477","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0043380","count":2},{"id":"GO:0032764","count":2}]},{"hash":"1422302740346317060","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":14,"triangles":9,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0006402","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0006189","count":3},{"id":"GO:0042245","count":3}]},{"hash":"999629920013361901","title":"Ubiquitin-Dependent Antiviral Immune Response","description":"The cluster is enriched for ubiquitin-related degradation and signaling processes (ubiquitin-dependent proteolysis, ERAD, K63-linked ubiquitination) alongside innate and antiviral immune functions (innate immune response, defense against virus, suppression of viral release). The combination suggests proteins that regulate ubiquitination to control antiviral signaling and antigen presentation, with implications for TNF signaling and adaptive immunity (dendritic cell and memory T cell differentiation). ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":7},{"id":"GO:1903265","count":6},{"id":"GO:0030433","count":5}]},{"hash":"1294977693751427094","title":"Larval chitin-based cuticle development","description":"The cluster is best captured by the prominent GO term GO:0008363 (larval chitin-based cuticle development) with 8 instances, indicating a core involvement in insect larval cuticle formation. While there are additional metabolic and mitochondrial assembly terms present, they are less represented, so the dominant signal is developmental related to the larval cuticle. ","confidence":"Medium","size":27,"edges":105,"triangles":159,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":8},{"id":"GO:1904960","count":1},{"id":"GO:0033132","count":1},{"id":"GO:0008535","count":1},{"id":"GO:0009636","count":1}]},{"hash":"992029463682080240","title":"Neuronal signaling and ion transport","description":"The top GO terms cluster around neural activity: cerebellar granule cell differentiation, long-term memory, excitatory postsynaptic potentials, and transferrable ion transport (sodium, potassium, calcium). This points to neuronal development and function with a focus on synaptic signaling and ion flux, supported by related mitochondrial and membrane-associated processes. Overall, the proteins seem tied to neural signaling and excitation rather than general metabolism or non-neuronal roles, justifying a label like this.","confidence":"High","size":27,"edges":51,"triangles":41,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":4},{"id":"GO:0006626","count":4},{"id":"GO:0007616","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0001975","count":3}]},{"hash":"840482404738329614","title":"MAPK/ERK and insulin signaling regulators in neural development","description":"This cluster prominently features GO terms about negative regulation of the ERK/MAPK cascade and insulin signaling, paired with neural-development related terms like cerebellar cortex formation and Bergmann glial cell differentiation. While immune signaling terms (T cell receptor pathway) appear, the shared core appears to be regulators of MAPK/ERK and insulin signaling with roles in neural development, particularly cerebellar-related processes and axon regeneration.","confidence":"Medium","size":27,"edges":346,"triangles":2807,"max_degree":26,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050860","count":19},{"id":"GO:0070373","count":19},{"id":"GO:0000200","count":19},{"id":"GO:0021697","count":17},{"id":"GO:0050852","count":17}]},{"hash":"1722023279753401953","title":"Ubiquitin-Dependent NF-\u03baB/TNF Signaling and Apoptosis","description":"This cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, and K63/K6-linked ubiquitination) together with TNF-mediated signaling and activation of NF-\u03baB-inducing kinase, plus regulatory roles in apoptosis and transcription. The common thread is ubiquitin-driven regulation of inflammatory signaling and cell fate, with one peripheral term related to muscle development. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0070535","count":4},{"id":"GO:2000312","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0007250","count":3}]},{"hash":"75260262970047360","title":"Inter-compartmental metabolite transport","description":"Reasoning: The top GO terms cluster around transport of small molecules across cellular compartments\u2014pyridoxal phosphate, pyrimidine nucleotides into mitochondria, CoA and NAD transmembrane transport\u2014along with ribosomal large subunit export from the nucleus. These points together suggest a shared function in moving metabolites and cofactors between organelles and the nucleus, rather than a single signaling or metabolic pathway. The label captures this broad transport theme while remaining concise.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0031921","count":2},{"id":"GO:0061179","count":2},{"id":"GO:0097421","count":2},{"id":"GO:1990519","count":2}]},{"hash":"1371604241211825584","title":"RNA Processing and Translation Initiation","description":"The cluster is dominated by RNA-processing activities (mRNA splicing via the spliceosome, small-subunit processome assembly, and regulation of mRNA polyadenylation) and by regulation of translation initiation (eIF4F complex assembly and translational initiation control). This points to a cohesive module involved in RNA maturation and in controlling protein synthesis, with miRNA-mediated silencing aligning with translational repression. Hence the label reflects a core RNA-processing and translation-regulation theme.","confidence":"High","size":27,"edges":50,"triangles":55,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":9},{"id":"GO:0045292","count":9},{"id":"GO:1903586","count":8},{"id":"GO:0035278","count":8},{"id":"GO:1900363","count":8}]},{"hash":"381394920308221557","title":"Neural development and Rho-cytoskeleton signaling","description":"The top GO terms cluster around neural development (hippocampus, forebrain, neural tube closure) and cytoskeleton regulation (Rho signaling, actin reorganization). This suggests a cohesive module where signaling through Rho pathways modulates cytoskeletal dynamics to drive neural development, with some additional immune-related terms reflecting broader signaling roles of these proteins.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007266","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0030900","count":2},{"id":"GO:2000727","count":2},{"id":"GO:0045736","count":2}]},{"hash":"1527552916237660514","title":"Spindle assembly and chromatin regulation","description":"The top terms point to mitotic processes (spindle assembly, centrosome cycle) and chromatin remodeling (histone H3 modifications), with apoptosis and development terms suggesting involvement in cell fate during development. This combination indicates a cluster centered on mitosis paired with chromatin regulation, with some developmental context.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":3},{"id":"GO:1901726","count":2},{"id":"GO:0044648","count":2},{"id":"GO:1901674","count":2},{"id":"GO:0097190","count":2}]},{"hash":"1785949330986824664","title":"Nuclear transport and cell division regulators","description":"This cluster emphasizes nuclear events linked to cell division (protein export from nucleus, mitotic nuclear membrane reassembly, meiotic telomere attachment to the nuclear envelope) and germline development (germ-line stem cell niche homeostasis and asymmetric division), suggesting a cohesive theme around nuclear dynamics during division and germline regulation. Some terms related to signaling and proliferation appear peripheral, making the core connection moderate.","confidence":"Medium","size":27,"edges":29,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0032926","count":1},{"id":"GO:0048147","count":1},{"id":"GO:0046827","count":1},{"id":"GO:0060250","count":1},{"id":"GO:0035307","count":1}]},{"hash":"1570830307692274889","title":"Unknown","description":"The top GO terms are scattered across several biological areas (blood coagulation; visual perception and retina development; sensory processing and prepulse inhibition; responses to drugs and MAMPs; nitrate transport; peptidoglycan catabolic process), with no clear, unifying function tying the proteins together. This heterogeneity makes a single, intuitive label unlikely, so the cluster is best described as Unknown.","confidence":"","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0007601","count":4},{"id":"GO:0060041","count":4},{"id":"GO:0015706","count":4},{"id":"GO:0001975","count":4}]},{"hash":"617372570191201621","title":"Multi-tissue Developmental Signaling","description":"The top GO terms point to various signaling pathways (Rho, ERK/MAPK, Roundabout) and broad developmental processes across multiple tissues (nervous system, immune cell differentiation, ossification, spermatid development, sarcomere organization). This suggests the cluster comprises proteins involved in general developmental signaling and differentiation across diverse biological contexts rather than a single, specific pathway or tissue.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0043552","count":4},{"id":"GO:0002551","count":4},{"id":"GO:0043931","count":4}]},{"hash":"1003955219437600543","title":"Apoptosis and Innate Immunity with Ubiquitination","description":"This cluster is dominated by apoptotic process (GO:0006915; 14), innate immune response (GO:0045087; 13), and protein ubiquitination (GO:0016567; 13), with pyroptotic inflammatory response (GO:0090307; 13) also prominent. The co-occurrence points to a module where programmed cell death and innate immune signaling are coordinated, with ubiquitin-dependent regulation, and supported by related cell adhesion and signaling terms. Overall, the central theme is apoptosis/pyroptosis linked to innate immunity, justifying this label.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":14},{"id":"GO:0045087","count":13},{"id":"GO:0016567","count":13},{"id":"GO:0090307","count":13},{"id":"GO:0070269","count":13}]},{"hash":"299091631712962288","title":"RNA processing and translation regulation under stress","description":"The top GO terms cluster around translation initiation (translation reinitiation, preinitiation complex formation), as well as mRNA processing/splicing and ncRNA/miRNA-mediated silencing, with supporting terms linking mRNA stability and stress responses (hypoxia). This points to a coherent module coordinating RNA metabolism, translation control, and gene silencing under stress conditions.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":13},{"id":"GO:0001731","count":13},{"id":"GO:0010610","count":9},{"id":"GO:0031047","count":9},{"id":"GO:0006378","count":9}]},{"hash":"721031988406748453","title":"DNA Metabolism and Xenobiotic Stress Response","description":"The cluster shows strong representation of DNA replication and DNA-templated transcription, indicating DNA metabolism activity, along with multiple cellular responses to xenobiotic stimuli (xenobiotic stimulus, alkaloid) and to growth factor stimuli, plus apoptotic signaling. Metabolic terms like sphingolipid metabolism and taurine biosynthesis suggest auxiliary signaling/metabolic layers that can integrate stress responses. Together, these terms point to a theme where DNA processing is linked to cellular stress and xenobiotic response pathways, justifying the label.","confidence":"Medium","size":27,"edges":37,"triangles":52,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0035690","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0006915","count":5},{"id":"GO:0006351","count":5}]},{"hash":"670941185272878043","title":"Innate immune signaling and phagocytosis","description":"Most terms cluster around innate immune recognition and signaling (phagocytosis recognition; C-type lectin and Fc-gamma receptor pathways; basophil activation; NK cell regulation). A few terms are developmental or vascular (lymph vessel morphogenesis, cartilage condensation, nephrogenesis), but they seem peripheral to the core immune signaling theme. Therefore, Innate immune signaling and phagocytosis is a concise, representative label.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":5},{"id":"GO:0036303","count":4},{"id":"GO:0090403","count":4},{"id":"GO:0002223","count":4},{"id":"GO:0038094","count":4}]},{"hash":"945902610547331999","title":"Retroviral DNA Integration and Latency","description":"GO terms point to retroviral life cycle steps: DNA integration into the host genome, establishment of proviral latency, RNA-templated DNA biosynthesis (reverse transcription), and entry of the virus into the host nucleus. The presence of DNA recombination and related processes supports a theme of proviral integration and maintenance, with some overlap to host-symbiont interactions. Overall, the dominant signal is retroviral integration and latency.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0039651","count":5}]},{"hash":"889523762882946526","title":"Chitin-based cuticle development and body morphogenesis","description":"This cluster is dominated by chitin-based cuticle development and body morphogenesis terms (8 each), suggesting a cohesive module focused on structural development and exoskeleton formation in arthropods. The other, less frequent terms (dsRNA response, interferon-alpha response, unfolded protein response, protein isomerization) appear as peripheral or secondary associations and do not define the main functional theme. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":8},{"id":"GO:0010171","count":8},{"id":"GO:0071360","count":1},{"id":"GO:0007091","count":1},{"id":"GO:0035845","count":1}]},{"hash":"252706567863691625","title":"Immune signaling and cytoskeleton dynamics","description":"The terms most represented point to immune receptor signaling (T cell receptor signaling, Fc receptor inhibitory signaling) and cytoskeletal remodeling (actin filament branching, plasma membrane tubulation), suggesting a cluster focused on immune signaling with actin-driven membrane dynamics. Other GO terms are more peripheral (polarity, peroxisomal import), so the core theme is immune signaling linked to cytoskeletal changes.","confidence":"Medium","size":27,"edges":24,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:2000769","count":1},{"id":"GO:1903764","count":1},{"id":"GO:0016560","count":1},{"id":"GO:0002774","count":1},{"id":"GO:0090135","count":1}]},{"hash":"2111468490748758304","title":"Angiogenesis and vascular signaling cluster","description":"The top terms center on blood vessel formation and endothelial behavior (angiogenesis, endothelial cell migration), coupled with key signaling pathways (ERK cascade, Wnt signaling, phosphatidylinositol/PI3K signaling) and GTPase regulation, suggesting a cohesive set of proteins coordinating vascular development through signaling networks; immune and neuronal terms appear less central to the core theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0051968","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0043536","count":3}]},{"hash":"1444583904655930577","title":"Ion and Sugar Transmembrane Transport","description":"The top GO terms are dominated by transmembrane transport of ions (sodium, potassium) and small molecules (galactose, xenobiotics), suggesting the cluster\u2019s proteins primarily function to move substrates across membranes. Some immune-related terms and a mitochondrial fission regulator appear but are less central to the main pattern. Overall, the strongest and most coherent signal is membrane transport of ions and metabolites.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0090141","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0071222","count":2}]},{"hash":"724490685074144930","title":"PNS development with inflammatory signaling","description":"The cluster centers on peripheral nervous system development (axonogenesis; myelination in PNS) but also includes strong immune signaling components (lipopolysaccharide response; inflammatory response; I-kappaB phosphorylation). Additional terms related to extracellular matrix (collagen fibril organization) and metabolism/regulation (thyroid hormone metabolism; negative regulation of protein kinase activity; mitochondrial depolarization) suggest supportive remodeling and signaling balance during neural-immune development. Overall, it plausibly groups PNS maturation with inflammatory signaling modules.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007409","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0051901","count":3}]},{"hash":"1245803254135875433","title":"Unknown","description":"The top GO terms span innate immune response, phagocytosis, and inflammatory response, but also include cerebellum morphogenesis, nerve branching, Wnt signaling, endosome-to-Golgi transport, and CAMKK-AMPK signaling. This mixture shows no single cohesive function for the entire cluster, so a specific descriptive name cannot be reliably assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0021587","count":3},{"id":"GO:0006909","count":3},{"id":"GO:0071560","count":3},{"id":"GO:1904887","count":2}]},{"hash":"745711545938304758","title":"Neural Development and Axon Guidance","description":"The dominant GO terms point to neuronal development and guidance: ROBO signaling, axon guidance, nervous system development, and sodium channel clustering, with supporting cell adhesion terms. While a few terms touch on skeletal/basement membrane aspects, the core theme is neural connectivity and adhesion during nervous system formation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035385","count":6},{"id":"GO:0032836","count":5},{"id":"GO:0007155","count":5},{"id":"GO:0045162","count":5},{"id":"GO:0007411","count":5}]},{"hash":"467829640881365588","title":"Unknown","description":"The top GO terms are scattered across diverse biological themes (cytoskeleton processes like microtubule severing and spindle assembly; various developmental programs in animals and plants; signaling and metabolism), with no clear, unidade function tying all proteins together. There are no edges among proteins, and only a few terms are repeated, indicating a heterogeneous set rather than a cohesive cluster.  ","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051013","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0000209","count":1},{"id":"GO:0007200","count":1}]},{"hash":"1673910466580365898","title":"Neuronal ion transport and signaling","description":"The cluster centers on ion transmembrane transport (Na+/K+), action potential, and neural functions such as hearing and balance/posture control, pointing to a cohesive theme of neuronal excitability and signaling. Peripheral terms like xenobiotic transport and acrosome-related processes appear less connected to the core neural theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0050885","count":2},{"id":"GO:0050884","count":2}]},{"hash":"2152373253773825273","title":"Neuronal development and synapse organization","description":"This cluster is dominated by neural development and synaptic assembly terms, including neuroblast differentiation, synaptic vesicle clustering, postsynaptic density (PSD-95) clustering, and regulation of inhibitory postsynaptic potentials, along with positive regulation of protein localization to synapse; retina development aligns with neural tissue, while osteoblast development is less central.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002076","count":14},{"id":"GO:0060041","count":14},{"id":"GO:0002087","count":14},{"id":"GO:0097151","count":11},{"id":"GO:0097091","count":11}]},{"hash":"155592951220904512","title":"Neural development and synaptic organization","description":"The top GO terms point to nervous system development and synaptic function: retina development, neuroblast differentiation, synaptic vesicle clustering, postsynaptic density clustering, and regulation of inhibitory postsynaptic potentials. While there are a few broader or outlier terms (e.g., transcription by RNA polymerase II, xenobiotic response, osteoblast development), the dominant signals are neural development and synaptic maturation/organization, justifying a neural-centric label.","confidence":"High","size":26,"edges":283,"triangles":1970,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":12},{"id":"GO:0002076","count":11},{"id":"GO:0002087","count":11},{"id":"GO:0042493","count":10},{"id":"GO:0006366","count":9}]},{"hash":"1490289990295783419","title":"Diverse Metabolite Biosynthesis","description":"The top GO terms point to biosynthetic and metabolic processes across a range of molecules, including androgens/hormones (androgen, testosterone, estrogen biosynthesis), vitamins (retinol), and other secondary metabolites (tropane alkaloids, phylloquinone, mycolic acid), with occasional drug-response terms. This suggests the cluster represents proteins involved in diverse biosynthetic and metabolic pathways rather than a single, cohesive pathway, hence a broad label like Diverse Metabolite Biosynthesis.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0061370","count":6},{"id":"GO:0006703","count":5},{"id":"GO:0031427","count":5}]},{"hash":"1455721293865371819","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":5,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042273","count":4},{"id":"GO:0000447","count":4},{"id":"GO:0000466","count":4},{"id":"GO:0060271","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1746394106995125122","title":"Ribosome biogenesis and translation during cell division","description":"The cluster shows strong enrichment for translation-related GO terms (translation, cytoplasmic translation) and ribosome biogenesis (ribosome biogenesis, ribosomal subunit biogenesis, ribosomal large subunit export, ribosomal small subunit biogenesis), along with cell division-related terms (cell cycle, cell septum assembly). This pattern suggests a core function in ribosome assembly and protein synthesis that is coordinated with cell division processes.","confidence":"High","size":26,"edges":73,"triangles":50,"max_degree":15,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0007049","count":5},{"id":"GO:0042274","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0000055","count":4}]},{"hash":"53756677225810282","title":"Endothelial barrier regulation and innate immunity","description":"The top GO terms cluster around vascular barrier control (endothelial barrier establishment; regulation of fibrinogen), innate immune signaling (Toll pathway), and anti-bacterial defense (response to LPS, defense against Gram-positive bacteria). Together these imply a cohesive theme of coordinating vascular integrity with innate immune responses, despite a few noisy or obsolete terms. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":9},{"id":"GO:0014068","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0032496","count":8},{"id":"GO:0050830","count":8}]},{"hash":"2222603255085648995","title":"Ubiquitin-mediated control of immune differentiation","description":"This cluster combines ubiquitin-dependent protein catabolic processes with several immune-related differentiation terms (dendritic cell differentiation, pro-T cell differentiation, T cell differentiation with memory formation, germinal center formation, and regulation of mast cell cytokine production). The shared thread appears to be ubiquitin signaling governing immune cell development and function, despite a few outlier terms such as phototropism/gravitropism likely representing annotation noise. ","confidence":"Medium","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:1900477","count":5},{"id":"GO:2001200","count":5},{"id":"GO:0043380","count":5},{"id":"GO:0032764","count":5}]},{"hash":"1189242940530545273","title":"Spliceosome-Driven mRNA Processing and Silencing","description":"Proteins in this cluster show strong enrichment for splicing-related processes (spliceosome-mediated and alternative mRNA splicing) and post-transcriptional regulation, including regulation of mRNA stability in response to stress and miRNA- or ncRNA-mediated gene silencing. The convergence on spliceosome activity and RNA silencing pathways suggests a cohesive role in RNA processing and post-transcriptional gene regulation.","confidence":"High","size":26,"edges":141,"triangles":681,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":14},{"id":"GO:0048026","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0006378","count":11},{"id":"GO:0045292","count":11}]},{"hash":"274353543388748127","title":"Glycosaminoglycan Proteoglycan Synthesis","description":"The Top Terms show strong enrichment for proteoglycan biosynthetic processes (heparan sulfate, chondroitin sulfate, keratan sulfate), indicating a cluster focused on glycosaminoglycan production and extracellular matrix assembly. A few metabolic and signaling terms appear, but they are secondary to the core GAG/proteoglycan biosynthesis theme.","confidence":"High","size":26,"edges":22,"triangles":5,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0015015","count":8},{"id":"GO:0030206","count":8},{"id":"GO:0050852","count":5},{"id":"GO:0006711","count":5},{"id":"GO:0006068","count":5}]},{"hash":"1939610385602941228","title":"Larval chitin-based cuticle development","description":"Based on the predominance of GO:0008363 larval chitin-based cuticle development (24 proteins) and the clustering of other developmental terms, this group is best described as proteins involved in insect larval cuticle formation and associated morphogenesis. While there are a few diverse terms (reproduction, immunity, etc.), the strongest signal points to cuticle biosynthesis and larval development.","confidence":"High","size":26,"edges":324,"triangles":2576,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":24},{"id":"GO:0043392","count":1},{"id":"GO:0007620","count":1},{"id":"GO:0048747","count":1},{"id":"GO:2000354","count":1}]},{"hash":"1715987494228475328","title":"Neural development and immune signaling","description":"The cluster highlights neural development signals (axonogenesis, excitatory postsynaptic potential) alongside major signaling pathways (MAPK, PI3K/AKT, tyrosine phosphorylation) and immune-related responses (LPS response, TNF production), suggesting a theme of signaling events that govern neural development and immune modulation, with some insect-specific cuticle development hints. Confidence in this connection is Moderate.","confidence":"Medium","size":26,"edges":86,"triangles":170,"max_degree":16,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0016525","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0006469","count":4}]},{"hash":"1280791326157134143","title":"Glycan and Proteoglycan Biosynthesis","description":"The cluster is driven by GO terms tied to biosynthesis of glycosaminoglycans and proteoglycans (chondroitin sulfate, heparan sulfate), glycosphingolipids (globoside), and related cell-surface glycans (Lewis antigens), indicating a cohesive role in assembling glycoconjugates on the cell surface. Although some terms are labeled obsolete, the overall pattern points to glycan and proteoglycan biosynthesis functions rather than unrelated processes like behavior. Confidence reflects this moderate but clear alignment to glycoconjugate production.","confidence":"Medium","size":26,"edges":32,"triangles":8,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":2},{"id":"GO:0015015","count":2},{"id":"GO:0051999","count":2},{"id":"GO:0036210","count":2},{"id":"GO:0001576","count":2}]},{"hash":"308951711324873228","title":"Larval cuticle development and stress signaling","description":"The dominant GO term is larval chitin-based cuticle development (9), suggesting a developmental role in larval cuticle formation. The presence of stress-related terms (regulation of cytoplasmic translation in response to stress, eIF2\u03b1 phosphorylation in ER stress, DNA damage checkpoint signaling, UV-C response, starvation responses) implies these proteins also participate in or respond to cellular stress pathways. Together, this points to a cluster centered on larval cuticle development with concurrent stress-response signaling, hence the combined label.","confidence":"Medium","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":9},{"id":"GO:1990497","count":1},{"id":"GO:0060765","count":1},{"id":"GO:0071494","count":1},{"id":"GO:0031333","count":1}]},{"hash":"79703847834893927","title":"Mitochondrial Cofactor Transport and Metabolism","description":"The top GO terms cluster around transport of key cofactors into mitochondria (pyridoxal phosphate, NAD, CoA) and mitochondrial nucleotide import, paired with related metabolic and redox processes (fatty acid response, superoxide handling, necroptosis regulation). This points to a coherent theme of mitochondrial cofactor import supporting metabolic regulation and energy production, with some terms reflecting broader physiological contexts like liver metabolism and pregnancy. Overall, these functions are cohesively tied to mitochondrial metabolite transport and metabolism.","confidence":"High","size":26,"edges":33,"triangles":1,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":13},{"id":"GO:0070542","count":13},{"id":"GO:0031921","count":12},{"id":"GO:0097421","count":12},{"id":"GO:1990519","count":12}]},{"hash":"686054043920882186","title":"Chitin-based cuticle development","description":"Top GO terms indicate a clear focus on chitin-based cuticle development and body morphogenesis, signaling involvement in exoskeleton formation and developmental shaping typical of arthropods. A few peripheral terms (e.g., regulation of mRNA stability, aging) appear sparsely and may reflect annotation noise or broader regulatory roles, but the dominant theme remains cuticle formation and morphology.","confidence":"Medium","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":3},{"id":"GO:0010171","count":3},{"id":"GO:0014912","count":1},{"id":"GO:0071320","count":1},{"id":"GO:0007568","count":1}]},{"hash":"1081829073448841655","title":"Cartilage, Bone Formation and Vascular Morphogenesis","description":"This cluster centers on developmental processes including chondrocyte formation, endochondral ossification, and morphogenesis of skeletal and vascular tissues, supported by terms like growth plate cartilage chondrocyte development, endochondral ossification, and aorta smooth muscle tissue morphogenesis; a few unrelated annotations may reflect broader physiological roles.","confidence":"Medium","size":26,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0044258","count":1},{"id":"GO:0030157","count":1},{"id":"GO:0018350","count":1},{"id":"GO:0035987","count":1},{"id":"GO:0071230","count":1}]},{"hash":"1861152529885862353","title":"Rho-regulated cytoskeleton and integrin signaling","description":"The terms show strong enrichment for regulation of Rho protein signal transduction, integrin activation and filopodium assembly, which point to cytoskeletal remodeling and cell-adhesion processes. Additional terms touch membrane trafficking and cholesterol response, suggesting a membrane-associated context. A few terms (heart development, sensory perception of sound) may reflect broad roles or annotation noise, but the dominant theme remains cytoskeleton and adhesion.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007605","count":4},{"id":"GO:0033622","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0071397","count":4}]},{"hash":"1691898209099217302","title":"Developmental Signaling and Heart Morphogenesis","description":"The top GO terms cluster around developmental signaling pathways (Wnt and Hippo), heart development processes (tricuspid valve morphogenesis, regulation of cardiac muscle cell proliferation), and broader regulatory activities (apoptosis, transcription regulation, nuclear export). While there is some diversity (e.g., keratinocyte differentiation), the dominant theme is signaling networks governing organ development and size, particularly in the cardiac context. This makes a label focused on developmental signaling and heart morphogenesis informative and representative.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060044","count":24},{"id":"GO:0090263","count":24},{"id":"GO:0030216","count":24},{"id":"GO:0035329","count":24},{"id":"GO:0006915","count":24}]},{"hash":"686064902056819238","title":"Mitochondrial dynamics during cell cycle","description":"These proteins cluster around mitochondrial remodeling (membrane organization, fission, and intracellular distribution) and core cell cycle processes (cell division and cell cycle progression), with apoptosis also represented. The combination points to a functional module coordinating mitochondrial dynamics with cell division and programmed cell death, with some auxiliary roles in protein oligomerization and nuclear transport. ","confidence":"High","size":26,"edges":34,"triangles":2,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0007006","count":4},{"id":"GO:0000266","count":4},{"id":"GO:0051260","count":4}]},{"hash":"1050523619997356269","title":"Heart, vascular, and neural development signaling","description":"The cluster is enriched for axonogenesis, angiogenesis, heart development, and broader organism development, with supporting signals from growth hormone receptor pathways and MAPK/JUN-related phosphorylation. This suggests a cohesive developmental signaling program coordinating neural growth, blood vessel formation, and cardiac development rather than a single enzymatic function.","confidence":"High","size":26,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007409","count":8},{"id":"GO:0001525","count":6},{"id":"GO:0060396","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007275","count":6}]},{"hash":"686299405180862487","title":"Viral integration and proviral latency","description":"This cluster is dominated by GO terms tied to DNA recombination, DNA integration, RNA-templated DNA biosynthesis, DNA repair, and DNA replication, together with virus-specific processes like viral penetration into the host nucleus and establishment of integrated proviral latency. The combination suggests a cohesive theme around incorporation and maintenance of viral genomes within host DNA (proviral latency) and the associated DNA metabolism steps. Confidence: High","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0046718","count":4}]},{"hash":"1299521321993405714","title":"Hepatic and cardiac development with metabolism","description":"The cluster combines GO terms for organ development (liver development, cardiac muscle differentiation) with metabolic pathways (heme biosynthesis, leucine catabolism, prostaglandin biosynthesis) and transcription activity, suggesting proteins involved in tissue development linked to metabolic signaling rather than a single canonical pathway.","confidence":"Medium","size":26,"edges":36,"triangles":23,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0006783","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0042594","count":2}]},{"hash":"1616371974635228470","title":"P450-mediated steroid and xenobiotic metabolism","description":"This cluster centers on cytochrome P450\u2013driven modifications across diverse substrates, including steroid hormone pathways (androgen, ecdysone, calcitriol) and xenobiotic/catabolic processes (camphor, carbazole). The co-occurrence of P450 pathway terms with hormone biosynthesis and detoxification tasks supports a unifying theme of P450-driven metabolism, despite some broader or less direct terms like ozone response or maternal processes. ","confidence":"Medium","size":26,"edges":31,"triangles":5,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":18},{"id":"GO:0090350","count":18},{"id":"GO:0019383","count":18},{"id":"GO:0097267","count":18},{"id":"GO:0046232","count":18}]},{"hash":"1952017907468368550","title":"Unknown","description":"There are no GO terms or interactions to define a shared function for this cluster; with 0 edges/triangles and no terms, a meaningful label cannot be inferred, even though some proteins were re-added by ReCIPE. ","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1662878508813768471","title":"Vascular and neural development with ECM remodeling","description":"The cluster is enriched for angiogenesis, CNS development, innervation, and collagen fibril organization, pointing to coordinated vascular and neural tissue development with extracellular matrix remodeling. Additional terms around Rho/PI3K signaling and response to mechanical stimulus support signaling and cytoskeletal changes typical of morphogenesis. A few terms (like B cell receptor signaling) are less directly related and may reflect broader annotations. Overall, the dominant theme is development of vascular and neural tissue with ECM organization.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007417","count":3}]},{"hash":"2035390042661206691","title":"Angiogenesis and vascular remodeling signaling","description":"These proteins show a shared emphasis on vascular biology, including angiogenesis, regulation of vascular permeability, blood pressure, coagulation, and fibroblast proliferation, with supporting calcium signaling and GTPase activity. The common thread is signaling pathways that drive blood vessel growth, endothelial activation, and vessel remodeling, rather than a single isolated function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0043114","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0090026","count":2}]},{"hash":"1798421397799463271","title":"Startle-Response and Synaptic Plasticity","description":"This cluster centers on neuronal excitability and synaptic plasticity underlying startle reflex and learning. GO terms emphasize Na+/K+ ion transport, excitatory postsynaptic potentials, and potentiation, plus behavioral readouts like prepulse inhibition, conditioned taste aversion, and ethanol response, with a fish sensory-development link (posterior lateral line). Overall, the proteins likely function in excitatory synaptic signaling and experience-dependent plasticity mediating sensory processing.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001964","count":9},{"id":"GO:0035725","count":8},{"id":"GO:1900273","count":8},{"id":"GO:0060134","count":8},{"id":"GO:0071805","count":8}]},{"hash":"1185662232312432956","title":"Unknown","description":"Top GO terms are diverse and span lipid regulation, chemotaxis, glucagon signaling, circadian rhythm, lactation, lung development, TGF-beta3 production, synaptic plasticity, osteoclast differentiation, and zinc response; no single unifying function ties these proteins together, so the cluster remains Unknown. ","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046889","count":1},{"id":"GO:0034670","count":1},{"id":"GO:0033762","count":1},{"id":"GO:0042752","count":1},{"id":"GO:0007595","count":1}]},{"hash":"898537336652276398","title":"Angiogenesis and vascular remodeling","description":"The cluster centers on processes related to blood vessel formation, extracellular matrix organization (collagen fibril), mechanosensitive responses, and vascular innervation, with additional signals related to platelet regulation and oxidative stress, pointing to coordinated vascular remodeling and angiogenic activity, potentially in a cardiac or tissue-vasculature context.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0010666","count":5},{"id":"GO:0071279","count":5},{"id":"GO:2001275","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0090331","count":4}]},{"hash":"859440746951595344","title":"Microtubule Dynamics & Centrosome Function","description":"The top GO terms cluster around centrosome separation and microtubule polymerization, with locomotion tied to cytoskeletal movement, pointing to microtubule organization and cell movement as the shared theme. Other terms (BMP signaling, immune signaling) are present but less central, suggesting these proteins collectively relate more to the cytoskeleton than to a single signaling pathway. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051299","count":5},{"id":"GO:0046785","count":5},{"id":"GO:0031987","count":5},{"id":"GO:0014068","count":2},{"id":"GO:0051092","count":2}]},{"hash":"2209720734368596615","title":"Transcriptional Regulation and Signaling Modulators","description":"Most GO terms point to regulatory roles rather than catalytic activity, with a strong emphasis on positive regulation of transcription by RNA polymerase II. Additional terms indicate modulation of signaling pathways (including androgen receptor signaling and adrenergic receptor\u2013mediated signaling), post-translational control (desumoylation), and immune modulation (IL-6 production). The set appears to be a collection of proteins that act as regulators of gene expression and signaling networks rather than a single enzymatic function, justifying a label around transcriptional and signaling regulation. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0032092","count":3},{"id":"GO:0032715","count":3},{"id":"GO:0090240","count":2},{"id":"GO:0090327","count":2}]},{"hash":"2152908019203497141","title":"Proviral DNA Integration and Latency","description":"The top GO terms cluster around viral DNA integration, proviral latency, and related replication/recombination steps, including RNA-templated DNA synthesis and viral entry into host genomes. This suggests the proteins are connected to the retroviral life cycle and host interactions governing proviral establishment and latency, despite a few outliers like a sugar metabolism term.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0006310","count":4}]},{"hash":"89308899980753511","title":"Neural development and synaptic regulation","description":"The top GO terms are dominated by nervous system development and synaptic functions, including short-term plasticity regulation and glutamatergic transmission modulation, with additional neurosensory development terms (lateral line). While there are a few outliers (sarcomere organization, dendritic cell differentiation), the prevailing pattern points to proteins involved in neural differentiation and controlling synaptic activity.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0050806","count":2}]},{"hash":"151146882271613392","title":"Transmembrane Transporters","description":"This cluster is dominated by transmembrane transport activities across a range of substrates\u2014potassium and sodium ions, nitrite, arabinose, galactose, fucose, 4-hydroxyphenylacetate, and xenobiotics\u2014with an additional role in neurotransmitter loading into synaptic vesicles. The unifying theme is membrane-embedded transporter proteins that move diverse molecules across the membrane, making Transmembrane Transporters a concise and representative label.","confidence":"High","size":25,"edges":59,"triangles":61,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0006855","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0042891","count":3}]},{"hash":"2219383137090501545","title":"Embryogenesis and placental development","description":"The top GO terms cluster around embryonic development, placenta formation and trophoblast differentiation (trophoblast giant cell differentiation, left/right patterning, EMT in endocardial cushion formation, cartilage morphogenesis, pancreatic cell development), with a notable emphasis on developmental and morphogenetic processes. A peripheral term about LPS response is present but does not define the core theme. Therefore the label reflects the primary shared function of these proteins: embryogenesis and placental development.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0060972","count":7}]},{"hash":"2073149737124858959","title":"Embryonic organogenesis and tissue differentiation","description":"This cluster is enriched for transcription-related processes (DNA-templated transcription; negative regulation of transcription by RNA polymerase II) and a broad set of embryonic development programs across multiple tissues (endocrine pancreas, skeletal muscle, neural crest, spermatid nucleus, atrial septum morphogenesis, endodermal fate, digestive tract morphogenesis, lung smooth muscle), suggesting a general developmental transcriptional regulatory module driving organogenesis.","confidence":"Medium","size":25,"edges":120,"triangles":292,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":16},{"id":"GO:0000122","count":11},{"id":"GO:0031018","count":11},{"id":"GO:0035914","count":10},{"id":"GO:0001755","count":9}]},{"hash":"2212460269594717481","title":"GPCR Endocytosis & Clathrin Trafficking","description":"The top GO terms indicate strong enrichment for G protein-coupled receptor internalization and clathrin-dependent endocytosis, suggesting a cluster focused on GPCR trafficking. Additional terms (ERK signaling, filopodium assembly, ubiquitination) align with signaling and cytoskeletal remodeling linked to endocytosis, with visual perception and heart development likely reflecting GPCR roles in those contexts. Overall, the common theme is GPCR endocytosis and associated trafficking.","confidence":"High","size":25,"edges":19,"triangles":0,"max_degree":18,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002031","count":11},{"id":"GO:0072583","count":11},{"id":"GO:0007601","count":9},{"id":"GO:0033138","count":9},{"id":"GO:0070374","count":9}]},{"hash":"800430960675368318","title":"Cell Adhesion and Migration Signaling","description":"Most enriched GO terms cluster around cell-cell adhesion (heterophilic/heterotypic adhesion), integrin-mediated signaling, and cell movement (extravasation, substrate-dependent migration) with some neural (axonal fasciculation) and immune (T cell activation) context. Together these suggest a cohesive theme of adhesion-mediated communication and migration across tissues, despite some single terms that reflect specific contexts. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007157","count":10},{"id":"GO:0046718","count":8},{"id":"GO:0032516","count":8},{"id":"GO:0002291","count":6},{"id":"GO:0035987","count":6}]},{"hash":"2121150086112050350","title":"Vertebrate organ development with innate immune signaling","description":"The cluster centers on vertebrate development (heart/pulmonary myocardium, midbrain, multicellular development) and key signaling (Wnt), with concurrent immune-related terms (LPS response, defense to Gram-positive bacteria, complement activation) and transcription regulation. This suggests proteins involved in coordinating organogenesis with signaling and innate immune responses, particularly cardiopulmonary development, though some terms are broader.","confidence":"Medium","size":25,"edges":5,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":10},{"id":"GO:0014068","count":9},{"id":"GO:0006958","count":9},{"id":"GO:0007275","count":8}]},{"hash":"438870684283748095","title":"Embryonic Development and Craniofacial Morphogenesis","description":"This cluster centers on embryonic development with strong signals for craniofacial structures (cranial skeleton morphogenesis, odontogenesis) and neural/brain patterning (midbrain development, motor neuron axon guidance), plus broader organ induction. The presence of Wnt signaling and regulation of Rho protein signal transduction suggests coordinated developmental signaling tied to morphogenesis and tissue patterning, making a label focused on embryonic craniofacial development appropriate.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0042475","count":3}]},{"hash":"309086440762055196","title":"Central metabolism and gene expression with stress responses","description":"The cluster shows strong signals for glycolysis and the TCA cycle (glycolytic process and tricarboxylic acid cycle) alongside core gene-expression machinery (DNA-templated transcription and translation). Additional terms point to cellular stress handling (response to lipopolysaccharide, xenobiotic stimulus, corticosterone), suggesting a cohesive group linked to metabolism, protein synthesis, and stress adaptation.","confidence":"High","size":25,"edges":175,"triangles":823,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0032496","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0006412","count":3}]},{"hash":"2260151119688470247","title":"Circadian Rhythm and Locomotor Behavior","description":"The cluster is dominated by GO terms tied to circadian biology and locomotor activity, including circadian sleep/wake cycle, entrainment by photoperiod, and regulation/maintenance of locomotor rhythms, as well as GPCR-cAMP signaling pathways often involved in circadian regulation. Gravitaxis and mating behavior further reflect insect behavioral phenotypes linked to daily activity patterns. A minor associating term about cuticle development appears less central. Overall, the core theme is circadian control of movement and daily behavior.","confidence":"High","size":25,"edges":31,"triangles":4,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0007617","count":3},{"id":"GO:0042332","count":3},{"id":"GO:0045475","count":3},{"id":"GO:0010579","count":3}]},{"hash":"2296725113760253710","title":"Proteoglycan biosynthesis and xenobiotic metabolism","description":"The cluster shows strong signals for glycosaminoglycan (keratan sulfate, chondroitin sulfate, heparan sulfate) and proteoglycan biosynthesis, pointing to ECM/glycosaminoglycan biology. It also highlights multiple xenobiotic and catabolic metabolic processes (bile acid, estrogen, ethanol, xenobiotic), suggesting coordinated metabolism and detox pathways. The embryonic neurocranium morphogenesis term adds a developmental ECM/deposition context, supporting a proteoglycan\u2013ECM theme. Overall, these terms converge on proteoglycan biosynthesis with associated metabolic processing.","confidence":"Medium","size":25,"edges":101,"triangles":138,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0030573","count":21},{"id":"GO:0015015","count":20},{"id":"GO:0030206","count":20},{"id":"GO:0006711","count":19},{"id":"GO:0006068","count":19}]},{"hash":"1537800881142267812","title":"Larval chitin-based cuticle development cluster","description":"The top GO term is larval chitin-based cuticle development (GO:0008363) with 22 proteins, suggesting the group is enriched for genes involved in forming the larval cuticle in arthropods. While a few other terms point to cytoskeletal and neuronal processes (e.g., filopodium assembly, dendritic spine morphogenesis, mitotic spindle assembly), the dominant signal is cuticle development, so the label reflects the main function of this cluster.","confidence":"High","size":25,"edges":264,"triangles":1609,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":22},{"id":"GO:0043524","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0031384","count":1}]},{"hash":"484970861964441946","title":"Larval chitin-based cuticle development","description":"Most proteins in this cluster are annotated with GO:0008363 (larval chitin-based cuticle development), with 23 of 25 proteins supporting this term, indicating a cohesive module likely focused on insect cuticle formation during larval stages. The other GO terms are sparse (mostly single occurrences) and seem incidental rather than defining the group\u2019s core function, suggesting the dominant theme is cuticle development. Therefore, this label captures the primary biological role of the cluster.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":23},{"id":"GO:0015862","count":1},{"id":"GO:0035364","count":1},{"id":"GO:0001766","count":1},{"id":"GO:0061028","count":1}]},{"hash":"1715574844518808914","title":"Innate immune signaling and inflammatory remodeling","description":"Based on the top terms, the cluster centers on innate immune response, Toll signaling, and inflammatory response, with additional signals of tissue remodeling such as collagen organization and regulation of angiogenesis. Ubiquitination and spliceosome-related terms may reflect regulatory aspects rather than core function, but do not outweigh the immune/inflammatory theme. Overall, this label captures the dominant function, with some peripheral roles represented; confidence is Medium.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0060527","count":2},{"id":"GO:0010748","count":2},{"id":"GO:0046676","count":2},{"id":"GO:0000350","count":2}]},{"hash":"823093582265128577","title":"Lymphocyte receptor signaling and innate immunity","description":"The top GO terms cluster around immune signaling: T cell receptor signaling, B cell differentiation/affinity maturation, Fc receptor\u2013mediated inhibitory signaling, and innate immune response, suggesting a module of lymphocyte activation and intercellular communication through receptor pathways. Additional terms like ephrin and neurotrophin receptor signaling indicate broader RTK-mediated signaling that can influence development and immune interactions; a heart development term may reflect shared signaling components rather than a primary function. Overall, the cluster seems best described as a lymphocyte receptor signaling module with innate immune activity.","confidence":"High","size":25,"edges":9,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0002774","count":6},{"id":"GO:0010863","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0007507","count":6}]},{"hash":"1331178330774883253","title":"Dendritic Spine Morphogenesis and Actin Remodeling","description":"The GO terms converge on neuronal spine biology and cytoskeletal dynamics: dendritic spine morphogenesis/development, lamellipodium and ruffle assembly, Rac signaling, and formin-mediated actin cable assembly, all pointing to actin-driven remodeling during spine formation. A hippocampal development hint and Golgi-to-plasma membrane transport support a neuronal growth and trafficking context. This suggests a cohesive theme of dendritic spine formation and associated actin remodeling.","confidence":"High","size":25,"edges":94,"triangles":105,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043001","count":7},{"id":"GO:0061001","count":5},{"id":"GO:0097178","count":5},{"id":"GO:0016601","count":5},{"id":"GO:0060999","count":5}]},{"hash":"1843751360841670199","title":"Transmembrane Transporters","description":"The top GO terms are all about transport across membranes for diverse substrates (xenobiotics, nitrate/nitrite, galactose, sodium, phosphate, vitamins, and sugars), with a related term for neurotransmitter loading into synaptic vesicles. This points to a set of membrane transporter proteins with broad substrate specificity, justifying the label Transmembrane Transporters.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0035725","count":3}]},{"hash":"1568471194628703201","title":"Embryogenesis and cell cycle regulation","description":"Top terms show a clear emphasis on developmental processes (multicellular organism development, skeletal system development, neural tube closure) alongside core cell cycle and transcriptional activities (mitotic cell cycle, DNA replication, DNA-templated transcription). An ER-stress\u2013linked apoptotic pathway indicates coupling of development with stress responses, while a defense response term may reflect cross-talk between immunity and development. Overall, these proteins appear to coordinate developmental progression with cell proliferation and gene expression control.","confidence":"High","size":25,"edges":68,"triangles":62,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":9},{"id":"GO:0007275","count":7},{"id":"GO:0070059","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0050830","count":7}]},{"hash":"2234386414843319772","title":"Post-transcriptional RNA processing and translation control","description":"The terms cluster around mRNA maturation and regulation, including splicing (cis splicing via spliceosome and regulation of alternative splicing), mRNA stability and polyadenylation, translational initiation control, and miRNA-mediated silencing, plus small-subunit processome assembly relevant to ribosome biogenesis. This combination points to a cohesive theme of RNA processing and post-transcriptional control of gene expression.","confidence":"High","size":25,"edges":167,"triangles":903,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":14},{"id":"GO:0006378","count":11},{"id":"GO:0045292","count":11},{"id":"GO:1903586","count":10},{"id":"GO:0035278","count":10}]},{"hash":"228143731740187982","title":"RNA processing and translation regulation","description":"The top GO terms cluster around mRNA processing (splicing regulation, polyadenylation regulation, mRNA stability) and translation control (formation of translation preinitiation complex, translation reinitiation, miRNA-mediated silencing by inhibiting translation). This suggests a cohesive role in post-transcriptional gene expression regulation, spanning both RNA maturation and translational control. Some terms are obsolete, but the core theme remains RNA processing and translation regulation.","confidence":"High","size":25,"edges":73,"triangles":80,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":13},{"id":"GO:0002188","count":13},{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:0006378","count":12}]},{"hash":"1679487287081990148","title":"Developmental signaling and cytoskeleton regulation","description":"These proteins collectively show enrichment for development-related processes (skin development, myelination, multicellular development, fertilization) alongside signaling and cytoskeletal remodeling activities (GTPase activity regulation, Arp2/3-mediated actin nucleation, serine/threonine kinase activity regulation, autophosphorylation). The cluster seems to group factors that drive developmental signaling while modulating the actin cytoskeleton, justifying a label that combines both themes.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0022011","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1722025431332304536","title":"Potassium Ion Homeostasis and Transport","description":"The top GO terms are dominated by potassium-related processes: intracellular potassium ion homeostasis, potassium ion transmembrane transport, and potassium export, with accompanying signals for sodium import and membrane repolarization in cardiac tissue. This suggests the cluster centers on ionic balance and membrane potential regulation, particularly for potassium. A few terms related to mechanosensation, aerotaxis, and development appear peripheral to the main theme.","confidence":"Medium","size":25,"edges":13,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":10},{"id":"GO:0098914","count":10},{"id":"GO:0071805","count":10},{"id":"GO:0050976","count":10},{"id":"GO:0098719","count":10}]},{"hash":"791222835640128536","title":"Neuroendocrine signaling and sensory perception","description":"The cluster is dominated by terms tied to neuronal and hormonal signaling affecting behavior and perception: circadian sleep regulation, startle response, pain detection, caffeine response, and vasopressin secretion, all pointing to neuroendocrine and sensory signaling. Calcium import supports signaling cascades, while a couple of terms (skin development, plant jasmonic acid biosynthesis) appear as unrelated outliers. Overall, a coherent theme is neuroendocrine and sensory signal transduction with behavioral outcomes.","confidence":"Medium","size":25,"edges":16,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":10},{"id":"GO:0045188","count":9},{"id":"GO:0001964","count":9},{"id":"GO:0098703","count":9},{"id":"GO:0071313","count":8}]},{"hash":"896786424583217650","title":"Chitin-based cuticle development and body morphogenesis","description":"This cluster is dominated by GO:0040003 (chitin-based cuticle development) and GO:0010171 (body morphogenesis), each represented by 16 proteins, suggesting a shared role in exoskeletal formation and epidermal shaping. The few occurrences of neuromuscular synaptic transmission and calcium channel clustering are rare, indicating these are not the primary functions of the cluster. Therefore the label reflects the strong association with cuticle formation and body morphogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":16},{"id":"GO:0010171","count":16},{"id":"GO:0007274","count":1},{"id":"GO:0070073","count":1}]},{"hash":"1180491315312006424","title":"Neural-Muscular Development and Signaling","description":"The cluster centers on developmental processes with strong neural and muscular connections: heart and Schwann cell development, visual perception, excitatory postsynaptic potential, and response to muscle activity, plus multicellular organism development. There is also indication of cell-cycle control and phosphorylation regulation, which often accompany differentiation and tissue growth. A few terms (e.g., abscisic acid signaling) are plant-specific annotations that may be incidental, but overall the prevalent GO terms point to coordinated neural, muscular, and developmental signaling. ","confidence":"Medium","size":25,"edges":111,"triangles":157,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0014850","count":19},{"id":"GO:0007507","count":19},{"id":"GO:0007601","count":19},{"id":"GO:0009738","count":19},{"id":"GO:0014044","count":19}]},{"hash":"524146989488060171","title":"Neural Development and Metabolic Signaling","description":"The cluster's top GO terms emphasize neural development and neurogenesis (e.g., nervous system development and forebrain proliferation) along with metabolic pathways (insulin receptor signaling, glucose transport, adipocyte differentiation, and lipid biosynthesis regulation). This suggests a combined role in neural development with metabolic signaling, though the terms are not tightly cohesive, so the label reflects the dominant neural-development theme with metabolic context.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900016","count":4},{"id":"GO:0022008","count":4},{"id":"GO:0048672","count":4},{"id":"GO:0048662","count":3},{"id":"GO:0008286","count":3}]},{"hash":"489367285257143364","title":"Developmental signaling and cytoskeletal regulation","description":"The proteins appear enriched for multicellular development (cartilage condensation, general development) and signals tied to cytoskeletal dynamics and intracellular trafficking (Rho signaling, GTPase activity, kinetochore localization, endosome transport), along with stress/fate-related processes (apoptosis, cadmium response, cellular response to fungal origin). This suggests a coherent theme of development-related signaling integrated with cytoskeletal regulation and trafficking.","confidence":"Medium","size":25,"edges":5,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071226","count":6},{"id":"GO:0001502","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0071276","count":5},{"id":"GO:0034501","count":5}]},{"hash":"984078066554661074","title":"Unknown","description":"The terms span a broad mix of processes across multiple tissues\u2014from vascular proliferation and angiogenesis to cardiac signaling, cell cycle, hormone secretion, neural differentiation, apoptosis, PARP activity, pain perception, cytokine regulation, and telomere biology\u2014without a single cohesive function tying them together, so this cluster cannot be assigned a specific high-level label.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":6},{"id":"GO:0086070","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0030103","count":6},{"id":"GO:0021707","count":6}]},{"hash":"833717482903762646","title":"Neural and cardiac electrical activity","description":"The terms cluster around electrical signaling and ion homeostasis in excitable tissues: glycinergic synaptic transmission and thalamus development point to neural signaling and brain development, while AV node action potential, potassium ion export/homeostasis, and diet/regulation of circadian sleep all relate to electrical excitability in heart and brain. A few biosynthetic process terms are obsolete, but the core theme ties to how neurons and cardiac cells regulate ions and electrical activity, with circadian/metabolic modulation as a secondary tie-in.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":3},{"id":"GO:0060012","count":3},{"id":"GO:0015015","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0007275","count":2}]},{"hash":"1355159593556878993","title":"Rho-driven synaptic spine morphogenesis","description":"The top terms point to synapse assembly and plasticity (receptor clustering; dendritic spine morphogenesis; long-term synaptic depression) and are complemented by Rho-mediated signaling and its regulation, consistent with actin remodeling underlying spine changes. A few telomere/heterochromatin-related terms appear but are likely outliers; the dominant theme is neuronal synapse organization and Rho signaling.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":3},{"id":"GO:0035390","count":3},{"id":"GO:0031848","count":3},{"id":"GO:0071919","count":3},{"id":"GO:0007266","count":2}]},{"hash":"119400521119750893","title":"Epithelial amino acid transport and signaling","description":"The top GO terms point to membrane transport of various amino acids (L-ornithine, D-serine, D-alanine, methionine, ammonium) and transepithelial transport, suggesting a core role in epithelial nutrient movement. Additional terms indicate related signaling and regulatory processes (ERK cascade regulation, nitric oxide production) and developmental contexts (lung connective tissue development, nipple morphogenesis), implying coordinated transport and signaling within epithelial biology. Overall, the cluster appears centered on epithelial amino acid transport with supporting regulatory roles.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060427","count":2},{"id":"GO:0060658","count":2},{"id":"GO:2000637","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0097640","count":2}]},{"hash":"1611472356265447490","title":"Neural development and GABAergic signaling","description":"The terms emphasize neural development (ventral spinal cord development, stem cell differentiation, astrocyte differentiation regulation) and GABAergic function (gamma-aminobutyric acid secretion), with a signal for clathrin-dependent endocytosis relevant to synaptic vesicle recycling. Translation and ubiquitin-dependent degradation are present but seem ancillary to the core neural/synaptic theme.","confidence":"Medium","size":24,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0046898","count":1},{"id":"GO:0046677","count":1}]},{"hash":"2303652940465434361","title":"Antibiotic biosynthesis and xenobiotic metabolism","description":"The top GO terms point to antibiotic biosynthesis (antibiotic biosynthetic process, clavulanic acid biosynthetic process) alongside several catabolic and metabolic pathways for diverse compounds (2,4-dichlorophenoxyacetic acid, xanthine, carbohydrates, carnitine) and cellular responses (SOS, cell division). This suggests a cluster of proteins involved in secondary metabolite production with broader metabolic and stress-response roles, rather than a single, narrow function. Medium","confidence":"","size":24,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0046300","count":3},{"id":"GO:0033050","count":3},{"id":"GO:0045329","count":3}]},{"hash":"190753113057927355","title":"Unknown","description":"The top GO terms cover vascular/immune processes (endothelial barrier regulation, LPS response, complement activation, cell adhesion) as well as diverse developmental topics (nephron differentiation, cerebral cortex development, endocrine system development) with no clear, cohesive function linking all proteins. No edges or shared pathway emerge to define a specific, common role for this cluster.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":4},{"id":"GO:0045944","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0014909","count":3},{"id":"GO:0006958","count":3}]},{"hash":"352345649585762958","title":"T and dendritic cell differentiation","description":"Most terms point to immune system development, particularly differentiation of dendritic cells and T cells, with related germinal center formation and regulation of mast cell cytokine production. A couple of plant-related terms appear unrelated and may be noise. Therefore, the cluster is best described as differentiation of adaptive immune cells, especially T and dendritic cells.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070294","count":11},{"id":"GO:1900477","count":10},{"id":"GO:2001200","count":10},{"id":"GO:0043380","count":10},{"id":"GO:0032764","count":10}]},{"hash":"955923116391366129","title":"Proteoglycan Biosynthesis and ECM Localization","description":"This cluster is dominated by GO terms related to glycosaminoglycan and proteoglycan biosynthesis and metabolism (heparan/chondroitin/dermatan sulfate) and polysaccharide localization, pointing to extracellular matrix (ECM) components. Developmental terms like chondrocyte development and ureteric bud formation further support ECM-associated roles in tissue formation. Although there is a transcription-templated term present, the strongest signal centers on proteoglycan biosynthesis and ECM localization, justifying this label despite some outliers.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0030208","count":1},{"id":"GO:0015014","count":1},{"id":"GO:0002063","count":1},{"id":"GO:0030206","count":1}]},{"hash":"1396521975579175678","title":"Protein acetylation and chromatin regulation","description":"This cluster is dominated by acetylation-related GO terms: peptidyl-lysine N6-acetylation, N-terminal acetylation, N-terminal peptidyl-glutamic acid acetylation, and general protein acetylation, plus subtelomeric heterochromatin formation, suggesting roles in post-translational modification and chromatin state control. Some terms (leaf formation, angiogenesis) indicate broader developmental signaling, but the strongest signal is acetylation/modification of proteins and chromatin. Confidence: Medium","confidence":"","size":24,"edges":16,"triangles":7,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0045150","count":14},{"id":"GO:0006348","count":13},{"id":"GO:0018003","count":13},{"id":"GO:2000025","count":12},{"id":"GO:0032920","count":12}]},{"hash":"1275834859587635011","title":"Membrane Solute Transporters","description":"The top GO terms center on transmembrane movement of diverse solutes\u2014ions (potassium, sodium), sugars (arabinose, galactose, fucose), nitrite, xenobiotics, and neurotransmitter loading into vesicles\u2014indicating these proteins function broadly as membrane transporters rather than a single substrate-specific class.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":11},{"id":"GO:0035725","count":10},{"id":"GO:0006855","count":8},{"id":"GO:0015707","count":8},{"id":"GO:0098700","count":8}]},{"hash":"2117391031769000411","title":"Chloroplast biosynthesis and import","description":"The top GO terms cluster around plant chloroplast\u2013related processes: abscisic acid biosynthesis, Mo-molybdopterin cofactor biosynthesis linked to plastid metabolism, protein import into chloroplast stroma, and stomatal movement. These collectively point to chloroplast biogenesis/metabolism and transport as the core theme; a few terms (ommochrome biosynthesis, follicle cell stalk formation, nucleus organization) appear as outliers or annotation noise. Overall, the cluster likely reflects chloroplast-associated biosynthesis and import functions.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009688","count":3},{"id":"GO:0018315","count":3},{"id":"GO:0006777","count":3},{"id":"GO:0045037","count":3},{"id":"GO:0010118","count":3}]},{"hash":"2142916602508982103","title":"Neural, skeletal, and cardiac development signaling","description":"The top GO terms point to developmental processes across neural (neural tube closure), skeletal, and cardiac tissues (skeletal system development, ventricular cardiac muscle cell development), alongside signaling and regulation (PI3K/AKT pathway, phosphorylation regulation, proteasomal degradation, cell proliferation, and hypertrophy regulation). This suggests a cohesive theme of developmental growth signaling operating in multiple tissue contexts, rather than a single, narrow function, hence a multi-tissue development signaling label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001843","count":4},{"id":"GO:0000186","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0010800","count":4},{"id":"GO:0000278","count":4}]},{"hash":"939035578065530938","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by GO:0008363 (larval chitin-based cuticle development) with 22 proteins, suggesting a cohesive insect cuticle formation/function theme. The few other terms present (e.g., neural development, antigen processing, amyloid formation) appear as sparse annotations and do not define the core function. Therefore, the cluster most plausibly represents larval cuticle-related proteins.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":22},{"id":"GO:0021747","count":1},{"id":"GO:0045654","count":1},{"id":"GO:0019886","count":1},{"id":"GO:1990000","count":1}]},{"hash":"7562026017901433","title":"Brain development and synaptic signaling","description":"The GO terms cluster around neural development and synaptic function\u2014inner ear receptor cell development, innervation, brain-region development (lateral geniculate nucleus), cholinergic synaptic transmission, dopamine secretion, long-term potentiation, and circadian regulation\u2014suggesting proteins mainly participate in neuronal development and brain signaling rather than peripheral tissues.","confidence":"High","size":24,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060119","count":7},{"id":"GO:0060384","count":7},{"id":"GO:1905920","count":7},{"id":"GO:1900273","count":7},{"id":"GO:0033603","count":7}]},{"hash":"2215817225466557036","title":"RIG-I/MDA5 Interferon Response","description":"The top GO terms focus on RIG-I and MDA-5 signaling, antiviral defense, and positive regulation of interferon and cytokine production (IFN-\u03b1/\u03b2, IL-6, IL-8). This indicates an innate immune pathway activated by viral RNA sensing, driving interferon-mediated antiviral responses, which best explains the cluster\u2019s functional theme.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042993","count":1},{"id":"GO:0032480","count":1},{"id":"GO:0039529","count":1},{"id":"GO:0002230","count":1},{"id":"GO:0032727","count":1}]},{"hash":"618814781549284220","title":"Circadian Rhythm and Locomotor Regulation","description":"The cluster is dominated by terms related to circadian biology\u2014circadian and sleep/wake cycles, their entrainment by photoperiod, and regulation of locomotor rhythm\u2014along with modules of GPCR signaling that can modulate circadian clocks via adenylate cyclase. This pattern points to proteins involved in circadian clock control and the regulation of movement tied to daily rhythms. While some terms like mating behavior and gravitaxis may reflect broader behavioral modulation, the central theme centers on circadian timing and locomotion.","confidence":"High","size":24,"edges":10,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007617","count":7},{"id":"GO:0042332","count":7},{"id":"GO:0045475","count":7},{"id":"GO:0010579","count":7},{"id":"GO:0010841","count":7}]},{"hash":"1966148382881888934","title":"Immune cell differentiation and signaling","description":"The top terms point to immune-related processes: regulation of dendritic cell differentiation and memory T cell differentiation, plus GPCR signaling and vitamin D response that modulate immune function. Ubiquitin-dependent proteolysis and PARylation indicate protein turnover and signaling in immune contexts. A few terms about dendritic spine development are neuronal and may reflect cross-annotation, but the cluster\u2019s dominant theme centers on immune cell differentiation and signaling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0061000","count":6},{"id":"GO:0042787","count":5},{"id":"GO:0007213","count":4},{"id":"GO:0033280","count":4},{"id":"GO:0046232","count":4}]},{"hash":"171062401029477477","title":"DNA replication and stress-response cluster","description":"The prominent terms include DNA recombination and DNA replication, pointing to genome maintenance. Other terms\u2014cell redox homeostasis, apoptotic process, and regulation of autophagosome assembly\u2014point to cellular stress responses, while signaling terms (Wnt, peptide hormone response) indicate coordinated signaling during stress. Taken together, these proteins likely participate in genome maintenance coupled with stress response pathways.","confidence":"Medium","size":24,"edges":23,"triangles":3,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0007568","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0071375","count":3},{"id":"GO:0006915","count":3}]},{"hash":"997261450101994525","title":"Unknown","description":"The top GO terms span diverse contexts from insect cuticle development to angiogenesis, cardiac signaling, neurodevelopment, apoptosis, PARP activity, pain sensing, and immune regulation, with no clear single function tying them together. The lack of network connectivity further suggests a heterogeneous collection rather than a cohesive pathway, so a broad Unknown label is most appropriate.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:1903589","count":2},{"id":"GO:0086070","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0030103","count":2}]},{"hash":"2252978498450131751","title":"Neural development and memory regulation","description":"The top GO terms point to neuronal signaling and learning processes: regulation of synaptic transmission and synaptic plasticity, memory stages (short/medium/long-term), and cerebellar granule cell differentiation, with some sensory system development terms (lateral line). This suggests proteins grouped around neural development and memory-associated synaptic modulation rather than non-neural processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":6},{"id":"GO:0050806","count":5},{"id":"GO:0048915","count":5},{"id":"GO:0048899","count":5},{"id":"GO:0048172","count":5}]},{"hash":"1258700513917470994","title":"BMP signaling and endocrine organ morphogenesis","description":"The dominant GO terms point to BMP signaling and development of endocrine organs (parathyroid, thyroid, adenohypophysis), plus related morphogenesis processes, suggesting a developmental signaling/organogenesis theme. Some terms appear species-specific or broad (yeast response, cuticle development), indicating mixed annotations and modest coherence.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030509","count":2},{"id":"GO:0060670","count":2},{"id":"GO:0060017","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0051591","count":2}]},{"hash":"553862202063038805","title":"Dopamine Uptake Regulation and ERK/PI Signaling","description":"The cluster\u2019s top GO terms point to signaling pathway regulation (GTPase activity, ERK1/2 cascade, phosphatidylinositol biosynthesis) with a strong neuronal component (positive regulation of dopamine uptake, visual learning), suggesting involvement in synaptic signaling and plasticity. Some terms (xenobiotic response, proliferation) are less specific but do not override the dominant neuronal signaling theme. Overall, the label reflects a coherent focus on dopaminergic signaling and ERK/PI-mediated neuronal signaling dynamics.","confidence":"Medium","size":24,"edges":12,"triangles":8,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0010513","count":5},{"id":"GO:0051586","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0008283","count":5}]},{"hash":"1399410791468708986","title":"Nitrate and Peptide Transport Signaling","description":"The strongest signals are about transport and utilization of nitrates and peptides (nitrate assimilation/transport and dipeptide/oligopeptide transport), paired with signaling pathways (GPCR signaling, pheromone response, auxin signaling). This suggests a cluster focused on membrane transporters that coordinate nutrient uptake with signaling processes, rather than a single developmental or catabolic pathway. A cuticle development term appears but is less central to the overall theme.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0019236","count":1},{"id":"GO:0007186","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0009734","count":1}]},{"hash":"1532816546700483359","title":"Insect cuticle development and morphogenesis","description":"The cluster\u2019s strongest signals are GO:0040003 (chitin-based cuticle development) and GO:0010171 (body morphogenesis), each with 11 annotations, pointing to developmental processes in insects. Other terms are low-frequency and don\u2019t form a cohesive alternative theme, so the dominant signal is cuticle formation and body morphogenesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":11},{"id":"GO:0010171","count":11},{"id":"GO:0009648","count":1},{"id":"GO:0001696","count":1},{"id":"GO:0045987","count":1}]},{"hash":"599454057598372303","title":"Ion and Sugar Transmembrane Transporters","description":"The cluster is dominated by GO terms for transmembrane transport of ions and small molecules (sodium, potassium, nitrite, arabinose, galactose, fucose) and includes a term related to neurotransmitter loading into synaptic vesicles, suggesting vesicular transport in neurons. This points to a cohesive set of membrane transporter proteins handling ion/sugar transport and related vesicle processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0021707","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0015707","count":4}]},{"hash":"1093520025240691794","title":"Dopaminergic signaling and visual perception","description":"The cluster is dominated by neural/sensory terms: dopaminergic synaptic transmission, visual perception, visual learning, and cocaine-related behavioral responses, plus ERK signaling and prostaglandin-responsive pathways that align with neural plasticity and signaling. While a few terms like DNA replication and macrophage chemotaxis are less connected, the overall theme centers on neural signaling and sensory processing.","confidence":"Medium","size":24,"edges":7,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0071380","count":5},{"id":"GO:0048148","count":5},{"id":"GO:0010759","count":5}]},{"hash":"464278815697615201","title":"Ubiquitination and ERAD-Mediated Stress Response","description":"The top GO terms point to protein ubiquitination and the ERAD pathway, including regulation of deubiquitination, alongside stress-response terms to heat and high light. This supports a cohesive theme of ubiquitin-dependent protein quality control via ERAD under stress conditions, with other non-dominant terms likely reflecting secondary functions. ","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009408","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0050774","count":3},{"id":"GO:0043029","count":3}]},{"hash":"417613924542519297","title":"Innate immune signaling and dsRNA response","description":"Proteins in this cluster predominantly map to innate immune pathways, including NOD-like receptor signaling, Toll signaling, and TLR3 signaling, along with a dsRNA response and immunoregulatory effects on B and T cells. A couple of developmental terms appear as potential noise, but the core theme is innate immune signaling and dsRNA responsiveness.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070434","count":2},{"id":"GO:0008063","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0006355","count":2}]},{"hash":"83473227766016908","title":"Steroidogenesis and lipid metabolism","description":"The cluster is enriched for androgen metabolic process and testosterone biosynthetic process, along with triglyceride metabolic process, pointing to lipid handling and steroid hormone production as the core theme. While ATP synthesis and oxidative-stress/detoxification terms appear, the strongest signal is toward steroidogenesis and lipid metabolism, with redox-related terms likely representing supporting facets. ","confidence":"Medium","size":24,"edges":41,"triangles":14,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0098869","count":2},{"id":"GO:0006641","count":2},{"id":"GO:0015986","count":2},{"id":"GO:0032094","count":2}]},{"hash":"1183463183674824013","title":"Methionine and choline one-carbon metabolism","description":"The top GO terms cluster around methyl-group\u2013related amino acid metabolism: choline catabolic process, S-methylmethionine cycle, L-methionine salvage, and betaine catabolic process, with an obsolete regulation of homocysteine. These point to one-carbon metabolism and methyl group transfer as the core function of the cluster. A few terms related to adrenergic signaling and drug-related behavioral responses appear but are much less central. Overall, the proteins most plausibly participate in methionine/choline\u2013linked one-carbon metabolism rather than signaling alone.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042426","count":3},{"id":"GO:0042558","count":3},{"id":"GO:0071267","count":3},{"id":"GO:0050666","count":3},{"id":"GO:0033528","count":3}]},{"hash":"695310430741782046","title":"Ubiquitin-Proteasome Pathway in Antiviral Immunity","description":"The top GO terms cluster around ubiquitin-dependent protein degradation and ubiquitination (ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein autoubiquitination) alongside innate antiviral defenses (innate immune response, defense response to virus, negative regulation of intracellular transport of viral material). Additional terms touch on circadian regulation and inflammatory signaling (regulation of circadian rhythm, TNF-mediated signaling), supporting a theme where ubiquitination modulates antiviral signaling and trafficking. The cluster thus seems to represent components of the ubiquitin-proteasome system engaged in antiviral immunity.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0000209","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0051607","count":6},{"id":"GO:0030433","count":6}]},{"hash":"50606803854344490","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"This cluster is characterized by strong emphasis on ubiquitin-mediated processes (ubiquitin-dependent proteolysis, autoubiquitination, various ubiquitin linkages) paired with innate immune and antiviral defense functions (innate immune response, defense against virus, NF-kappaB and TNF signaling). The combination suggests a coherent role in ubiquitin-regulated antiviral innate signaling and related apoptosis pathways.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0045087","count":11},{"id":"GO:0051607","count":11},{"id":"GO:0051865","count":10},{"id":"GO:0070535","count":9}]},{"hash":"1621983455192503740","title":"Unknown","description":"The top GO terms are dispersed across transport, development, transcription regulation, and mitochondrial processes, with no single shared function and no network connections, so a coherent label cannot be inferred.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0048733","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0045137","count":1},{"id":"GO:2001229","count":1}]},{"hash":"362910011898882236","title":"Unknown","description":"The top GO terms are a mix of disparate processes (methionine salvage, threonine biosynthesis, phosphorylation, antibiotic response, spermatogenesis, proteasome-ubiquitin\u2013dependent degradation, mitotic spindle elongation, Wnt signaling in osteoblast differentiation, lactose catabolism), and the cluster has no edges connecting the proteins. This lack of a cohesive functional theme makes it impossible to assign a meaningful, specific label. Confidence: None","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019509","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0009088","count":3},{"id":"GO:0016310","count":3},{"id":"GO:0046677","count":3}]},{"hash":"646510627702804167","title":"Immune signaling and cytoskeletal remodeling in phagocytosis","description":"This cluster is enriched for immune-related processes (adaptive immune response, TH1 differentiation, phagocytosis, integrin signaling) and cytoskeletal dynamics (microtubule polymerization, actin cytoskeleton remodeling, cell-matrix adhesion regulation). The combination suggests proteins involved in immune cell signaling that coordinate cytoskeletal changes to mediate phagocytosis and related responses, with some auxiliary associations to amyloid-beta response and growth regulation. Edges are absent in this dataset, indicating the GO term enrichment pattern rather than a connected interaction network.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046785","count":3},{"id":"GO:0001953","count":2},{"id":"GO:1904645","count":2},{"id":"GO:0046676","count":2},{"id":"GO:0031532","count":2}]},{"hash":"1972039786027692070","title":"Axon guidance and neural crest migration","description":"The cluster is dominated by terms for neural crest migration, axon guidance, neuron projection extension/fasciculation and semaphorin-plexin signaling, suggesting a cohesive function in neural development; occasional lens morphogenesis and spermatid development terms likely reflect shared developmental roles rather than core function of the cluster.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036486","count":3},{"id":"GO:0097491","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0021637","count":3},{"id":"GO:1902287","count":3}]},{"hash":"361953374165676948","title":"Neural development and synaptic signaling","description":"This cluster centers on neural development and synaptic function, with terms for synaptic transmission (positive and negative regulation, glutamatergic, neuromuscular), short/long-term plasticity, memory, and cerebellar granule cell differentiation, plus lateral line system development, indicating cohesive neural signaling and development themes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043523","count":5},{"id":"GO:0050806","count":4},{"id":"GO:0048915","count":4},{"id":"GO:0048899","count":4},{"id":"GO:0048172","count":4}]},{"hash":"2209843841771951356","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040038","count":1},{"id":"GO:0006929","count":1},{"id":"GO:0071689","count":1},{"id":"GO:0070649","count":1},{"id":"GO:1904171","count":1}]},{"hash":"572347168356188146","title":"Neural development and axon guidance","description":"The cluster shows strong representation of neural crest migration, neuron projection development, axon extension, and semaphorin-plexin\u2013mediated axon guidance, spanning multiple cranial nerves and sensory structures, indicating a cohesive role in neural development and neuron pathfinding.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036486","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0010693","count":2},{"id":"GO:0097491","count":2},{"id":"GO:0021637","count":2}]},{"hash":"820428191620458763","title":"Immune receptor signaling and cytoskeletal regulation","description":"The cluster\u2019s top GO terms group around B cell homeostasis, antigen receptor\u2013mediated signaling, and integrin activation, along with actin cytoskeleton organization and GTPase activation. These point to coordinated immune signaling coupled to cytoskeletal remodeling, suggesting a shared functional module in leukocyte activation and adhesion. Some terms like heart development or hydrotropism are peripheral but may reflect broader signaling cross-talk. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0001782","count":2},{"id":"GO:0018107","count":2},{"id":"GO:0072332","count":2},{"id":"GO:0008344","count":1}]},{"hash":"892355205906500949","title":"RNA silencing in meristem and germline development","description":"This cluster centers on RNA-based regulation, with GO terms for miRNA and piRNA processing/silencing, and miRNA metabolism. It also includes plant developmental terms like regulation and maintenance of shoot apical meristem identity, alongside germline-related processes such as spermatid development and megasporocyte differentiation, suggesting a theme of RNA-mediated control of developmental programs in meristem and reproductive tissues, possibly spanning plant and animal contexts.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009791","count":2},{"id":"GO:0035279","count":1},{"id":"GO:0035278","count":1},{"id":"GO:0034587","count":1},{"id":"GO:1902183","count":1}]},{"hash":"1427050226072999791","title":"Cardiac muscle contraction and sarcomere organization","description":"This cluster is dominated by GO terms related to heart and muscle function, including cardiac muscle contraction, sarcomere organization, and regulation of heart rate by epinephrine, as well as vascular smooth muscle regulation. A few terms appear unrelated (nitrate assimilation, auxin signaling, dipeptide transport) and likely fall outside the primary theme, but the core signal points to cardiac/sarcomeric muscle biology. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":6},{"id":"GO:0034609","count":6},{"id":"GO:1904753","count":6},{"id":"GO:0060298","count":6},{"id":"GO:1904706","count":6}]},{"hash":"89974481090679622","title":"Neural and cardiac development signaling","description":"The top GO terms cluster around developmental signaling and adhesion, including Hedgehog (Smoothened) signaling, BMP signaling, axon guidance, neuron projection development, and heart development, along with cell\u2013cell adhesion. While there are a few immune-related terms (ADCC) that are less central, the dominant theme points to signaling pathways driving neural and cardiac development and associated adhesion processes. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0030513","count":4},{"id":"GO:0007411","count":4},{"id":"GO:0007507","count":4}]},{"hash":"1837156193985687229","title":"Wnt-driven development and cell polarity","description":"The top GO terms point to signaling and polarity roles (Wnt signaling; establishment of epithelial cell polarity) with related cytoskeletal regulation (Rho signaling) and processes tied to morphogenesis and tissue formation (bone development, angiogenesis). Although some terms reflect specialized functions (vasopressin secretion, SA node communication), the dominant theme centers on developmental signaling and cell polarity guiding tissue and vessel formation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0048549","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1863549635135063460","title":"Actin dynamics in neural and skeletal development","description":"The cluster centers on actin filament depolymerization (cytoskeletal remodeling) and developmental processes such as neuron projection development, osteoblast differentiation, and skeletal system development, suggesting proteins involved in cytoskeletal changes during neural and bone formation. Some terms for skin development, ion transport, and coagulation appear but do not outweigh the core theme of actin-related development. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":3},{"id":"GO:0031175","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0070208","count":2}]},{"hash":"1394782185668180485","title":"Developmental signaling and organogenesis","description":"The top GO terms center on developmental processes across multiple organs and stages (cardiac left ventricle formation, ascending aorta morphogenesis, osteoblast differentiation, pancreatic PP cell fate, hair cycle regulation, Notch signaling). Although there is a plant-specific term (stomatal complex development) and some metabolic signaling terms, the overall pattern points to conserved developmental programs guiding organ formation and tissue specification, justifying a label focused on developmental signaling and organogenesis.","confidence":"High","size":23,"edges":246,"triangles":1632,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":11},{"id":"GO:0060766","count":11},{"id":"GO:0010374","count":10},{"id":"GO:0032933","count":10},{"id":"GO:0035910","count":10}]},{"hash":"1082591173461899004","title":"Multi-tissue organogenesis","description":"Top GO terms indicate development and morphogenesis across multiple tissues (heart, retina, placenta, osteoblasts, habenula, etc.), suggesting a unifying theme of embryonic organ development rather than a single tissue function.","confidence":"Medium","size":23,"edges":125,"triangles":218,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0002076","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0002087","count":9}]},{"hash":"129098267971262559","title":"Metabolic biosynthesis and chemical stress response","description":"The top GO terms cluster around biosynthesis of vitamins and cofactors (biotin, cobalamin, menaquinone) and related metabolism, plus methylation processes (rRNA and peptidyl-lysine dimethylation) and cellular responses to chemical stimuli (amines, xenobiotics) and osmotic stress. This suggests a theme of metabolic/cofactor biosynthesis with associated chemical stress adaptation, rather than a single unified pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0009102","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0009236","count":5},{"id":"GO:0019505","count":4},{"id":"GO:0031167","count":4}]},{"hash":"1932845266464188109","title":"Embryonic development and organ morphogenesis","description":"Top terms suggest broad embryogenesis and organ formation across multiple tissues (placental/trophoblast differentiation, left-right patterning, heart cushion EMT, cartilage morphogenesis, pancreatic beta-cell development, midbrain development) with concurrent transcriptional regulation. The shared theme is developmental programs guiding tissue specification and morphogenesis, so this label appropriately captures the cluster.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0003198","count":4}]},{"hash":"224745754800325026","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around embryonic development and tissue morphogenesis across multiple organs and processes (placental/trophoblast differentiation, EMT in heart development, mesoderm formation, cartilage and hair follicle morphogenesis, pancreatic cell development, facial structure formation, and left-right patterning). This suggests the proteins participate in broad developmental signaling and tissue shaping rather than a single organ-specific function, justifying a high-level label of embryonic development and morphogenesis.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":8},{"id":"GO:0060707","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0060536","count":8}]},{"hash":"2018431004210777555","title":"Embryonic morphogenesis and transcription regulation","description":"This cluster centers on chromatin remodeling and transcriptional control, paired with multiple embryonic morphogenesis processes (neural crest migration, cranial skeleton formation, pancreas development, ureteric bud branching). The combination suggests proteins that coordinate developmental morphogenesis through epigenetic and transcriptional regulation of gene expression across diverse embryonic tissues.","confidence":"High","size":23,"edges":58,"triangles":41,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043044","count":6},{"id":"GO:0048557","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0001755","count":5},{"id":"GO:0031018","count":5}]},{"hash":"219029470816628537","title":"Developmental transcriptional regulation","description":"The top GO terms emphasize both positive and negative regulation of RNA polymerase II transcription, paired with a broad array of developmental processes (midbrain development, endocrine system development, placenta and cartilage formation, pancreatic cell development, left-right patterning, and EMT events). This pattern suggests proteins that regulate transcription during embryogenesis and organ development, rather than a single tissue-specific function, hence a label centered on developmental transcriptional control.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060707","count":6}]},{"hash":"19986175163738601","title":"Nuclear RNA Processing and Spliceosome Assembly","description":"This cluster is dominated by GO terms tied to RNA metabolism and processing in the nucleus, including tRNA processing, maturation of SSU-rRNA, termination of RNA Pol II transcription, and histone mRNA metabolism, plus assembly of the spliceosome and snRNPs, and nuclear import. The presence of P-body assembly also aligns with mRNA processing and turnover, supporting a cohesive theme of nuclear RNA processing and spliceosome machinery.","confidence":"High","size":23,"edges":111,"triangles":259,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008033","count":8},{"id":"GO:0051170","count":7},{"id":"GO:0000387","count":7},{"id":"GO:0042633","count":7},{"id":"GO:0006369","count":7}]},{"hash":"386346355488152500","title":"Inflammatory Signaling and Chemokine Regulation","description":"The top GO terms cluster around inflammatory signaling, including production of inflammatory mediators and regulation of chemokine production, suggesting a shared immune-response function. Other terms like blood coagulation and cell adhesion fit vascular-immune cross-talk, while metabolism and chitin-related terms appear as outliers.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":3},{"id":"GO:0002532","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0072012","count":1}]},{"hash":"177147542564241478","title":"Embryonic development and organ morphogenesis","description":"This cluster centers on embryonic development, tissue differentiation, and organogenesis across multiple tissues (cartilage morphogenesis, endocrine and pancreatic development, left-right patterning, EMT in endocardial cushions, trophoblast differentiation) with additional signals for immune cell differentiation (B cell receptor signaling, dendritic cell differentiation). The ubiquitin-dependent protein catabolic process suggests regulation of protein turnover during these developmental programs. Overall, it points to a developmental/differentiation role rather than a single pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:2001200","count":10},{"id":"GO:0060806","count":10},{"id":"GO:0060707","count":10},{"id":"GO:0003198","count":10}]},{"hash":"983451946403809648","title":"Fungal-innate immune recognition and phagocytic signaling","description":"This cluster is dominated by GO terms related to innate immune sensing and response to fungi, including cellular response to molecules of fungal origin, lectin pathway complement activation, C-type lectin receptor signaling, Fc receptor signaling, phagocytosis, basophil activation, and regulation of NK cell chemotaxis. Together these imply a cohesive module for fungal detection and effector leukocyte activation (phagocytosis, cytotoxic signaling). Some terms like cartilage condensation and lymph vessel morphogenesis appear as broader developmental contexts but do not redefine the core immune-focused theme. ","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":16},{"id":"GO:0001867","count":14},{"id":"GO:0001502","count":13},{"id":"GO:0036303","count":12},{"id":"GO:0090403","count":12}]},{"hash":"311495449925535400","title":"Innate Immune Receptor Signaling and Phagocytosis","description":"This cluster is enriched for immune signaling and phagocytic functions. GO terms such as stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, phagocytosis recognition, and basophil activation point to innate immune recognition and effector responses. Additional terms related to NK cell chemotaxis regulation and lymph vessel morphogenesis suggest immune cell interactions and trafficking. A few developmental terms are present but do not dominate the set, so the core theme is innate immune receptor signaling and phagocytosis.","confidence":"High","size":23,"edges":104,"triangles":215,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":8},{"id":"GO:0090403","count":8},{"id":"GO:0002223","count":8},{"id":"GO:0006910","count":8},{"id":"GO:0038094","count":8}]},{"hash":"2050930950198401572","title":"Developmental Signaling and Morphogenesis Regulators","description":"These proteins are linked to developmental processes such as palate, mesoderm, hair follicle, and mammary gland morphogenesis, and involve key signaling pathways like TGF-beta and Wnt. They also touch on transcriptional and RNA processing regulation, suggesting the cluster comprises regulators that coordinate gene expression during development. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0060762","count":2},{"id":"GO:0090090","count":2},{"id":"GO:0000055","count":1}]},{"hash":"2078265761183247029","title":"Cell Proliferation and Mitochondrial Function","description":"This cluster centers on growth and division signals (mitotic cell cycle, cell division) alongside mitochondrial-related processes (regulation of aerobic respiration, protein import into the mitochondrial intermembrane space) and stress responses (cellular response to oxidative stress). Transcriptional activity and developmental terms (DNA-templated transcription, endoderm development) point to broader regulation of growth and development, but the strongest cohesive themes are proliferation and mitochondrial/metabolic regulation.","confidence":"Medium","size":23,"edges":26,"triangles":5,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0070651","count":2},{"id":"GO:0000278","count":2},{"id":"GO:1903715","count":2},{"id":"GO:0051301","count":2}]},{"hash":"107598169554787944","title":"Larval chitin-based cuticle development","description":"The top GO term is larval chitin-based cuticle development (12 proteins), indicating this cluster largely comprises proteins involved in forming the larval exoskeleton. A minor signal for keratinization (1) hints at a broader link to epidermal differentiation and protective layer formation. The network metrics (Edges 25, Triangles 7, Max Degree 9) support a cohesive developmental module focused on cuticle synthesis and organization. Confidence: High","confidence":"","size":23,"edges":25,"triangles":7,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":12},{"id":"GO:0031424","count":1}]},{"hash":"208142623774353105","title":"Cardiac morphogenesis and vascular differentiation","description":"The top GO terms are dominated by heart-related development: cardiac right atrium morphogenesis, endocardial cushion development, venous endothelial cell differentiation, Notch signaling in secondary heart field cardioblast proliferation, and multicellular organism development; a few terms like ossification and respiratory system process appear but are less central. This suggests a cluster of proteins involved in heart formation and vascular differentiation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0003270","count":2},{"id":"GO:0003213","count":2},{"id":"GO:0060843","count":2},{"id":"GO:0043931","count":2}]},{"hash":"1137983723046833169","title":"RNA processing and translation initiation","description":"Top terms cluster around mRNA maturation (splicing via spliceosome, alternative splicing regulation, polyadenylation) and the initiation of translation (translation initiation regulation, eIF4F complex assembly, small-subunit processome assembly). This indicates a cohesive group of RNA processing and translation initiation factors involved in early gene-expression steps.","confidence":"High","size":23,"edges":10,"triangles":5,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":9},{"id":"GO:0045292","count":8},{"id":"GO:1903586","count":7},{"id":"GO:0035278","count":7},{"id":"GO:1900363","count":7}]},{"hash":"1791313861819577396","title":"Mitochondrial protein targeting and respiration","description":"The cluster is enriched for mitochondrial-related terms, especially mitochondrial respiratory chain complex IV assembly (3 proteins) and aerobic respiration, with related GO terms indicating protein targeting to membranes (SRP-dependent and post-translational) and retrograde transport. While a few terms (e.g., larval cuticle development or obsolete annotations) may reflect noise, the dominant theme ties to mitochondrial protein import/assembly and energy metabolism.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":3},{"id":"GO:0008363","count":1},{"id":"GO:0000060","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0031204","count":1}]},{"hash":"44090401451887407","title":"RNA processing and translational regulation","description":"The cluster is enriched for terms related to RNA metabolism and control of protein synthesis, including regulation of mRNA stability during stress, mRNA splicing and polyadenylation, formation of translation preinitiation complexes, regulation of translational initiation and reinitiation, and miRNA-mediated silencing of translation. These collectively point to a coherent group of proteins involved in RNA processing and the control of translation, including viral translation contexts.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":13},{"id":"GO:0006378","count":12},{"id":"GO:0006446","count":11},{"id":"GO:0045292","count":11},{"id":"GO:0001731","count":11}]},{"hash":"2233950157749091968","title":"Heat and light stress response cluster","description":"The dominant GO terms point to cellular responses to heat and high light exposure (GO:0009408, GO:0009644, GO:1900034), with links to oxidative stress regulation and protein stabilization, suggesting a cohesive theme around stress response and protection under heat/light stress. A few outlier terms (e.g., lens fiber cell morphogenesis) appear but do not override the overall pattern of stress-adaptive functions. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009644","count":1},{"id":"GO:0032387","count":1},{"id":"GO:0007568","count":1},{"id":"GO:1900034","count":1},{"id":"GO:0032463","count":1}]},{"hash":"586472465312824155","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning cuticle development, plant hormone signaling, muscle organization, nervous system development, immune germinal centers, circadian regulation, and mitotic spindle functions, with no single shared function tying the proteins together. With zero edges and no dominant theme, a coherent cluster label cannot be determined.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":2},{"id":"GO:0010171","count":2},{"id":"GO:0035853","count":1},{"id":"GO:0009742","count":1},{"id":"GO:0051260","count":1}]},{"hash":"970374271201261808","title":"Unknown","description":"The top terms are a highly heterogeneous mix across development (cuticle, forebrain, cardiac muscle differentiation, vascular smooth muscle migration) and DNA-related processes (DNA binding regulation, mismatch repair, DNA recombination), with no shared biological theme or functional cluster given the zero edges. This makes it unclear what cohesive function ties the proteins together.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0045910","count":1},{"id":"GO:0006298","count":1},{"id":"GO:0010735","count":1},{"id":"GO:0055012","count":1}]},{"hash":"1141878421357382039","title":"Insect larval development and morphogenesis","description":"The top terms are dominated by developmental and morphogenetic processes (larval cuticle development, muscle and skeletal development, roof of mouth/craniofacial development, ovarian follicle regulation), suggesting a cluster focused on organismal development. A few terms relate to regulation of DNA binding or immune response, but the core signal aligns with developmental programs.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0043392","count":3},{"id":"GO:0007620","count":3},{"id":"GO:0048747","count":3},{"id":"GO:2000354","count":3}]},{"hash":"2158967040572120512","title":"Broad-spectrum transmembrane nutrient transporters","description":"GO terms indicate transmembrane transport of xenobiotics, vitamins, sugars, heme, and related metabolites, plus a glucose-starvation response, implying a cluster of membrane transport proteins with diverse substrates rather than a single substrate.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0035461","count":5},{"id":"GO:0015886","count":4},{"id":"GO:1990539","count":4},{"id":"GO:0044381","count":4}]},{"hash":"1705384074259576869","title":"Muscle satellite cell activation and translation regulation","description":"The terms show a combination of translation (protein synthesis) and a specific muscle regeneration process: satellite cell activation in skeletal muscle regeneration. Hypoxia response and regulatory processes also align with stress-adaptive gene expression during repair. While some terms are generic (DNA binding regulation, mitochondrial translation), the presence of the satellite cell activation term supports a muscle regeneration\u2013oriented cluster centered on translation regulation during repair.","confidence":"Medium","size":23,"edges":239,"triangles":1568,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0008284","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0006919","count":3},{"id":"GO:0043388","count":3}]},{"hash":"604292041976013132","title":"Hair follicle keratinization and morphogenesis","description":"This cluster centers on skin/hair differentiation and structural cross-linking, highlighted by keratinization and hair follicle morphogenesis, as well as isopeptide cross-linking via transglutaminases. While coagulation-related terms appear, the strongest and most specific signals are related to hair/skin development and protein cross-linking in the keratinocyte lineage, suggesting a cohesive theme of hair follicle formation and keratinization. ","confidence":"High","size":23,"edges":39,"triangles":21,"max_degree":18,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0051482","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0007200","count":3},{"id":"GO:0072378","count":3},{"id":"GO:0031424","count":3}]},{"hash":"2045335344951975132","title":"Unknown","description":"The top GO terms cover insect-like developmental processes (larval cuticle, mesoderm, heart development) as well as neural (synapse organization, dendritic spine regulation) and immune-related activities (lipopolysaccharide response, B cell maturation) and general transcription and signaling processes. The wide range of biological themes lacks a single coherent function or pathway tying the proteins together, making a specific label difficult. ","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0071222","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0048339","count":2}]},{"hash":"185990439380308156","title":"Neurovascular development and adhesion","description":"The cluster is enriched for neural development terms (positive regulation of glutamatergic synaptic transmission, axon extension, Notch receptor processing), as well as cell adhesion (cell-cell and cell-matrix adhesion) and vascular development (sprouting angiogenesis regulation, coronary artery morphogenesis). This pattern suggests a cohesive program coordinating neural connectivity with blood vessel formation, mediated by adhesion and signaling pathways. A minor presence of complement-related terms may reflect developmental immune remodeling but does not undermine the main neurovascular/adhesion theme.","confidence":"High","size":23,"edges":25,"triangles":21,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051968","count":14},{"id":"GO:0007157","count":13},{"id":"GO:0007160","count":13},{"id":"GO:0090051","count":12},{"id":"GO:0034351","count":12}]},{"hash":"2130573036993469713","title":"Immune signaling and host interaction","description":"The top GO terms are dominated by immune-related processes such as complement activation (classical pathway), Fc-epsilon receptor signaling, and production of monocyte chemotactic protein-1, all pointing to immune activation and signaling leading to leukocyte recruitment. There are also terms related to host cell interaction, like symbiont entry into the host cell, suggesting possible host-pathogen interaction or extracellular signaling events. Some outlier terms (DNA integration, ossification, endodermal differentiation) may reflect annotation noise or multi-functional proteins rather than a single cohesive pathway, but the strongest, recurring theme centers on immune signaling and host response. Overall, the cluster appears to represent innate immune signaling with potential host interaction roles.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071639","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0035584","count":2}]},{"hash":"1247611388854323172","title":"Developmental translational initiation regulation","description":"Top GO terms indicate a core emphasis on regulation of translation initiation and assembly of the translation preinitiation complex (GO:0006446, GO:0001731), paired with multiple development-related terms (heart, brain, retina, male gonad). This points to a theme of coordinating protein synthesis during developmental programs. Additional terms (e.g., ubiquitin-dependent ERAD pathway) are broader or historical, suggesting some pleiotropic regulators rather than a single cohesive pathway. Overall, the most coherent interpretation is developmental translational initiation regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0006446","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1431915757523024865","title":"Neuronal development and synaptic plasticity","description":"This cluster\u2019s top GO terms cluster around neural development and synaptic function, including cerebellar granule cell differentiation, long-term synaptic depression, positive regulation of synaptic transmission, and regulation of short-term neuronal synaptic plasticity. Additional terms touch on social behavior and lateral line system development, with Wnt signaling involved in neural patterning; an apoptotic process term may reflect general developmental remodeling. Despite no network edges, the enriched functions point to neurons and synaptic signaling as the cluster\u2019s overarching theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0016055","count":2}]},{"hash":"1686861491016361283","title":"Neuronal synaptic plasticity and behavior","description":"This cluster is enriched for terms about regulation of both short- and long-term neuronal synaptic plasticity, regulation of synaptic transmission, and behavioral or sensory phenotypes (social behavior, ethanol response, perception of sound). A few developmental terms (lateral line system, cuticle) suggest a zebrafish context but the core signal centers on neuronal signaling and behavior modulation. This supports a label focusing on neuronal plasticity and behavior.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0048149","count":2},{"id":"GO:0048169","count":2}]},{"hash":"1979969328791491122","title":"Neural synaptic signaling and plasticity","description":"The top GO terms point to neuronal communication and synaptic modulation\u2014excitatory postsynaptic potentials, GABA signaling, dopamine secretion, and long-term potentiation\u2014along with innervation and sensory-related inner ear development. These together suggest proteins functioning in synaptic transmission and plasticity, rather than general metabolism. Some terms (like skeletal muscle growth) are less central but do not override the dominant neural signaling theme.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":21},{"id":"GO:0001661","count":21},{"id":"GO:0007214","count":21},{"id":"GO:0060119","count":20},{"id":"GO:0060384","count":20}]},{"hash":"1442068572923757055","title":"Transmembrane and Vesicular Transport of Sugars and Metabolites","description":"The cluster is dominated by GO terms for transmembrane transport across membranes, including xenobiotic, vitamin, nitrite, and multiple sugar transports, plus a vesicle-related term (neurotransmitter loading into synaptic vesicles). This points to a coherent theme of membrane transporters handling diverse substrates and vesicular transport processes, rather than a single substrate type.","confidence":"High","size":23,"edges":231,"triangles":1344,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":23},{"id":"GO:0042891","count":23},{"id":"GO:0035461","count":23},{"id":"GO:1990539","count":22},{"id":"GO:0015707","count":22}]},{"hash":"486048971826170279","title":"Transmembrane Transporters for Ions and Metabolites","description":"Top GO terms show broad transmembrane transport activities across ions, nutrients, and xenobiotics, plus a transporter-related role in neurotransmitter loading, indicating a cohesive membrane-transport function rather than catalytic activity.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0006855","count":4},{"id":"GO:0042128","count":4},{"id":"GO:0015757","count":4}]},{"hash":"1607073290000257134","title":"Ribosome biogenesis and rRNA processing","description":"This cluster shows strong enrichment for ribosome-related processes, including maturation of 5.8S and LSU rRNA and ribosomal large subunit biogenesis, along with RNA guanine-N7 methylation. While other terms like transcription, mitosis, and stress responses appear, the ribosome/RNA processing signals are the most cohesive theme, justifying this label. Confidence: Medium.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0042273","count":3}]},{"hash":"937738808730440531","title":"Developmental transcription in cardiac and mesenchymal lineages","description":"The cluster shows strong enrichment for DNA-templated transcription and various differentiation processes (mesenchymal stem cell differentiation, limb bud formation, endocardial differentiation, ossification, and cardiac morphogenesis). Although there are no interactions, the common thread is transcriptional regulation guiding multicellular development in heart-related and mesenchymal tissues.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:2000741","count":2},{"id":"GO:0046533","count":2},{"id":"GO:0060956","count":2},{"id":"GO:0060174","count":2}]},{"hash":"1281155837563478304","title":"Placental and embryonic development","description":"The cluster is dominated by terms related to placenta formation (trophoblast giant cell differentiation, embryonic placenta development, endocrine system development) and broad embryonic organogenesis (left-right pattern formation, EMT in heart development, cartilage morphogenesis, pancreatic cell development), with supporting signals of transcriptional regulation during development. This makes a placenta/embryonic development label appropriate and representative.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0060707","count":6},{"id":"GO:0045944","count":5},{"id":"GO:0032496","count":5},{"id":"GO:0035270","count":5}]},{"hash":"1006081521937583095","title":"Innate immune signaling and host defense","description":"The top GO terms cluster around innate immune responses and Toll-mediated signaling, including defense against Gram-positive bacteria, response to lipopolysaccharide, and positive regulation of Toll signaling, as well as responses to yeast. While there are some developmental or growth-related terms present (e.g., pancreas morphogenesis, amelogenesis), the dominant theme is immune signaling and host defense, suggesting these proteins function together in innate immune pathways. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":11},{"id":"GO:0050830","count":10},{"id":"GO:0032496","count":9},{"id":"GO:0061113","count":9},{"id":"GO:1902947","count":8}]},{"hash":"198430321562201630","title":"Neuronal Signaling and Development","description":"The cluster shows strong signals for neuronal activity and signaling (sodium/potassium ion transport; excitatory postsynaptic potential) together with developmental signaling (mesoderm formation; neural tube patterning; kinase activity regulation). While DNA replication is present, the dominant themes point to neural excitability, synaptic signaling, and related developmental regulation, suggesting a group of proteins coordinating neural development and signaling pathways.","confidence":"High","size":22,"edges":74,"triangles":117,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0033138","count":3}]},{"hash":"2153074877614741073","title":"Small-molecule biosynthesis and amino acid metabolism","description":"The top GO terms indicate a mix of biosynthetic pathways for cofactors and vitamins (biotin, molybdopterin cofactor, L-ascorbic acid) and related pigment/porphyrin biosynthesis, along with amino acid catabolism (aspartate, alanine) and a tryptophan-derived metabolite. This points to a broad metabolic module focused on biosynthesis and turnover of small molecules rather than a single specific pathway. Medium","confidence":"","size":22,"edges":141,"triangles":529,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0006777","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0070584","count":2}]},{"hash":"1261728533376047606","title":"Neural development and differentiation cluster","description":"The cluster shows strong enrichment for neural development terms (spinal cord motor neuron fate specification, GABAergic interneuron differentiation, oligodendrocyte fate specification, subpallium fate commitment, retina development) with additional developmental terms across other tissues (pancreas, bronchiole, osteoblast). This points to a shared theme of developmental differentiation, especially in neural lineages, hence the label. ","confidence":"Medium","size":22,"edges":209,"triangles":1292,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0031018","count":7},{"id":"GO:0021520","count":7},{"id":"GO:0021892","count":7},{"id":"GO:0021530","count":7}]},{"hash":"731061941350970736","title":"Unknown","description":"The top GO terms present a broad and disparate mix: transcription, multiple amino acid catabolic/biosynthetic processes, retinol and kynurenine metabolism, Notch signaling, and antibiotic response, with several obsolete terms. There is no single coherent function tying these proteins together, so a specific cluster name cannot be confidently assigned.","confidence":"","size":22,"edges":54,"triangles":66,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0019518","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0000105","count":4}]},{"hash":"82856852772410856","title":"Neural development and inhibitory synapse assembly","description":"The cluster\u2019s top GO terms show a coherent theme around neural differentiation and development (floor plate development, somitogenesis, amacrine cell differentiation) alongside DNA-templated transcription and RNA polymerase II\u2013mediated transcription, suggesting a set of transcriptional regulators driving neural patterning and synapse formation (inhibitory synapse assembly). Some terms like xenobiotic response and osteoblast-related regulation are peripheral but may reflect broader developmental gene programs. Overall, the data point to neural development and synapse assembly as the core theme.","confidence":"Medium","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:1904862","count":6},{"id":"GO:0006366","count":6},{"id":"GO:0042493","count":5},{"id":"GO:0045668","count":5}]},{"hash":"710515178548963568","title":"Arabinogalactan Protein Glycosylation in Plants","description":"This cluster is dominated by GO terms tied to arabinogalactan protein (AGP) biosynthesis and hydroxyproline-dependent O-glycosylation, including AGP metabolic processes, complex glycan epitopes (e.g., Lewis A), and related mucilage/seed coat development and root hair formation. Together these point to a cohesive module of plant cell-surface glycoprotein production and glycosylation that underpins cell adhesion, polarity, and surface interactions during development. Some terms may appear cross-kingdom, but the strongest signal centers on plant AGP biology.","confidence":"High","size":22,"edges":28,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":8},{"id":"GO:0030311","count":7},{"id":"GO:0080147","count":7},{"id":"GO:0007299","count":7},{"id":"GO:0010493","count":7}]},{"hash":"1637961948613182930","title":"Embryonic and placental development with transcriptional regulation","description":"The dominant GO terms point to development and differentiation from embryonic to placental lineages (in utero embryonic development, placental development, trophoblast differentiation, EMT in heart cushion formation, endocrine system development). The presence of negative regulation of transcription by RNA polymerase II suggests coordinated gene regulation during these developmental processes, supporting a cohesive embryonic/placental differentiation program.","confidence":"High","size":22,"edges":35,"triangles":1,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0021983","count":6},{"id":"GO:0045654","count":5},{"id":"GO:0001701","count":5},{"id":"GO:0043046","count":5}]},{"hash":"1756715458282949263","title":"Diverse Biosynthetic Metabolism and Drug Response","description":"This cluster groups proteins enriched for a wide variety of biosynthetic processes across hormones, vitamins, lipids, alkaloids, and microbial components, along with transcription regulation and drug response terms, suggesting a broad metabolic/regulatory function rather than a single, cohesive pathway. The label captures the overall theme of diverse biosynthesis and xenobiotic response represented in the GO terms.","confidence":"Medium","size":22,"edges":101,"triangles":191,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":22},{"id":"GO:0006703","count":22},{"id":"GO:0031427","count":22},{"id":"GO:0042376","count":22},{"id":"GO:0046677","count":22}]},{"hash":"215535036139766372","title":"Developmental transcriptional regulation","description":"This cluster shows enrichment for transcription-related processes (DNA-templated transcription, negative regulation of transcription by RNA polymerase II), chromatin modification (histone H3 acetylation), RNA processing (mRNA splicing via spliceosome), and developmental signals (left/right pattern formation, endocrine system development). Together these points suggest a set of nuclear proteins that regulate gene expression during development and differentiation, with supporting roles in chromatin state and RNA processing. Although a few terms like sporulation appear, the dominant theme is transcriptional control in development.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0006349","count":2}]},{"hash":"1410251027311549122","title":"Carbohydrate catabolic processes","description":"This cluster\u2019s GO terms are dominated by sugar-specific catabolic pathways (L-fucose, rhamnose, L-arabinose/D-arabinose, L-lyxose) and L-ascorbic acid catabolism, suggesting a shared function in carbohydrate breakdown. A few outliers (obsolete methionine salvage terms and a pyroptotic/inflammatory term) exist but do not override the main theme. Therefore, the label reflects sugar catabolism.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019509","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0042355","count":3},{"id":"GO:0070269","count":3},{"id":"GO:0019301","count":3}]},{"hash":"978185269254570663","title":"Neural Development and Axon Guidance","description":"The cluster is dominated by GO terms tied to nervous system development, especially visual system components: heart development and skeletal muscle terms are present but less central, while neuron migration, retinal ganglion cell axon guidance, visual perception, and cytoplasmic microtubule organization point to neural development and axon pathfinding. The microtubule organization term supports cytoskeletal remodeling needed for neuron migration and axon extension, further aligning with a neural development theme. Together, these terms suggest a cohesive focus on neural/visual system development and axon guidance rather than unrelated processes.","confidence":"High","size":22,"edges":11,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0007601","count":5},{"id":"GO:0001764","count":5},{"id":"GO:0031122","count":5},{"id":"GO:0031290","count":4}]},{"hash":"474508574212765529","title":"Multitissue Development and Neural Differentiation","description":"The GO terms point to broad developmental processes across tissues (muscle, forebrain, cerebellum, spleen) and organogenesis, including neural guidance and transcription/mRNA processing, suggesting a cohesive theme of developmental regulation rather than a single pathway. The sparse connectivity (one edge) aligns with a cluster of genes involved in general differentiation programs across tissues.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007519","count":4},{"id":"GO:0006355","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0048536","count":4}]},{"hash":"911340841425797148","title":"Cytoskeletal Dynamics in Development","description":"The cluster shows strong signals for developmental processes (larval chitin-based cuticle development, brain development, trabecula morphogenesis) and cytoskeleton-related activities (filopodium assembly, mitotic spindle assembly), linked with membrane signaling (phosphatidylinositol biosynthesis). This indicates a cohesive theme around how cytoskeletal dynamics drive development and morphogenesis.","confidence":"Medium","size":22,"edges":37,"triangles":20,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":13},{"id":"GO:0007420","count":2},{"id":"GO:0043524","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0090051","count":1}]},{"hash":"1279752929590528327","title":"Larval chitin-based cuticle development","description":"The most enriched term is larval chitin-based cuticle development (GO:0008363), found in 13 of 22 proteins, indicating the cluster largely centers on insect cuticle formation. Additional terms about ER stress and protein folding appear as supporting cellular processes but do not override the main developmental theme.","confidence":"High","size":22,"edges":211,"triangles":1206,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":13},{"id":"GO:0006986","count":2},{"id":"GO:0071374","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0036494","count":2}]},{"hash":"1885970541108336742","title":"Dopaminergic signaling and sensory perception","description":"This cluster is dominated by neural functions: sensory perception (pain, vision), visual learning, and dopaminergic synaptic transmission, along with a cocaine-related behavioral response, all pointing to neural signaling and sensory processing. The ERK1/2 cascade also links to synaptic plasticity in these pathways. Some development and inflammatory-related terms appear, but the core theme is neural signaling and perception, especially involving dopamine and reward-related responses.","confidence":"Medium","size":22,"edges":35,"triangles":12,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0007275","count":8},{"id":"GO:0071380","count":7},{"id":"GO:0048148","count":7},{"id":"GO:0010759","count":7}]},{"hash":"1449355104553941224","title":"Developmental patterning and organogenesis","description":"This cluster centers on developmental biology, with terms spanning embryonic patterning (left-right formation), tissue differentiation, and morphogenesis (cartilage development, EMT in heart development, placental/trophoblast differentiation, pancreatic development). While one term references larval cuticle development and another is a general splicing process, the overall theme is organisms' development and organ formation. Therefore, the label reflects the common function tying many proteins together.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0000733","count":2},{"id":"GO:0000398","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1}]},{"hash":"160485145037250488","title":"Translation initiation and ribosome maturation","description":"The cluster centers on RNA processing and protein synthesis, with terms for translation preinitiation complex formation and SSU-rRNA maturation, plus mRNA transport. Some terms also reflect stress or proliferation signals (hypoxia response, mitotic cell cycle, ERAD), but the core theme ties to translation initiation and ribosome biogenesis.","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0008284","count":4}]},{"hash":"1329472664408807766","title":"Keratan sulfate proteoglycan biosynthesis and developmental signaling","description":"This cluster is dominated by terms related to the synthesis of keratan sulfate proteoglycans (a key extracellular matrix component) and related glycosylation processes, suggesting a proteoglycan/ECM biosynthesis theme. In addition, several terms point to signaling and developmental processes (ERK1/2 cascade, hormone secretion, reproductive development), which together imply a link between ECM biosynthesis and developmental signaling. Some terms (like LPS response and visual learning) appear less connected and may reflect broader or pleiotropic roles. Overall, the label captures the core proteoglycan biosynthesis function with a developmental signaling context.","confidence":"Medium","size":22,"edges":38,"triangles":9,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":4},{"id":"GO:0006486","count":4},{"id":"GO:0018146","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0032496","count":2}]},{"hash":"815439883701227424","title":"Synaptic Transmission Regulation and Lateral Line Development","description":"The cluster\u2019s top GO terms cluster around neuronal signaling and sensory system development: positive regulation of synaptic transmission, regulation of short-term neuronal synaptic plasticity, and negative regulation of glutamatergic transmission, plus anterior and posterior lateral line development. While a couple of terms touch on ion transport and digestion, the dominant signal is neural communication and sensory organ development, suggesting proteins linked to neuronal signaling pathways and lateral line sensory biology.","confidence":"Medium","size":22,"edges":21,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0044258","count":1},{"id":"GO:0030157","count":1},{"id":"GO:0018350","count":1}]},{"hash":"1799225786638377158","title":"Neural signaling and learning","description":"The top GO terms are dominated by nervous system functions: dopamine catabolic process, long-term synaptic depression, locomotory behavior, response to amphetamine, and visual learning, suggesting a core theme of neural signaling and learning. There are also developmental terms (skeletal system, roof of mouth) and insect-specific cuticle/chitin terms that may reflect broader or non-neural annotations, but the strongest signal centers on neural function and plasticity.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042420","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0008363","count":2}]},{"hash":"2502546632928852","title":"BMP-SMAD signaling in tissue differentiation","description":"The terms include lens fiber differentiation, cerebellar/Purkinje cell differentiation, myelination, BMP signaling, SMAD signaling, and related transcriptional regulation, pointing to a common theme of developmentally driven tissue differentiation governed by BMP/SMAD pathways across multiple tissues.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":4},{"id":"GO:2000249","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0032092","count":3},{"id":"GO:0035263","count":2}]},{"hash":"1215242596036769940","title":"Developmental Regulation and Apoptosis","description":"Based on GO terms, the cluster centers on organismal development (placenta, skeletal system, multicellular development) and general transcription and cell-cycle processes, with notable emphasis on apoptosis and ER-stress\u2013driven intrinsic signaling. The combination suggests proteins that participate in developmental regulation with stress-responsive control of cell fate, rather than a single, narrow function.","confidence":"Medium","size":22,"edges":7,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0071375","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0001890","count":4},{"id":"GO:0007275","count":4}]},{"hash":"2009291043563989637","title":"Mesodermal organogenesis: heart and kidney development","description":"The proteins cluster around mesoderm-derived organ formation, with strong signals for heart and kidney development, cranial skeleton morphogenesis, and BMP signaling regulation, all core to mesodermal patterning and organogenesis. Additional terms on cell adhesion/junctions fit the morphogenetic context, while complement and T cell apoptosis terms may be incidental. Overall, the dominant theme is mesodermal organogenesis and heart/kidney development.","confidence":"High","size":22,"edges":57,"triangles":0,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048378","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0030913","count":6},{"id":"GO:0048701","count":6}]},{"hash":"634728463110609969","title":"Retroviral genome integration and proviral latency","description":"The Top Terms cluster around DNA replication and DNA integration, with key viral-related steps such as viral penetration into the host nucleus, establishment of integrated proviral latency, and RNA-templated DNA biosynthetic process (reverse transcription). The presence of components like negative regulation of siRNA processing aligns with viral strategies to counter host defenses, reinforcing a retroviral life-cycle interpretation. Some terms about symbiont entry and apoptosis reflect pathogen-host interactions but do not override the retroviral emphasis.","confidence":"High","size":22,"edges":10,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0006310","count":4}]},{"hash":"481373335677188816","title":"Unknown","description":"The top GO terms span endocrine signaling (vitamin D response, vasopressin secretion), vascular development (angiogenesis), cardiac communication (SA node to atrial cardiomyocytes), cell cycle and apoptosis, neural differentiation, immune regulation, and DNA modification. The diverse functions across tissues do not point to a single cohesive role for the cluster, making a specific, representative name difficult. ","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:1903589","count":3},{"id":"GO:0086070","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0030103","count":3}]},{"hash":"923841141387163254","title":"Vertebrate organ development and transcription","description":"The prominent terms center on vertebrate organ development (pharyngeal system, kidney, skeletal) and transcriptional activity (DNA-templated transcription) with regulatory signaling (phosphorylation). Although antibiotic response and innate immunity appear, the strongest signal ties to developmental processes and gene regulation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0019509","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0009088","count":3},{"id":"GO:0016310","count":3}]},{"hash":"2140706521657589252","title":"Unknown","description":"The top GO terms include immune defense (defense response to Gram-positive bacterium, innate immune response) but also a diverse set of developmental processes across different tissues (lung development, nipple morphogenesis, cartilage condensation, kidney tubule morphogenesis, lymph vessel morphogenesis). There is no clear, singular functional theme linking these terms, suggesting the cluster may be heterogeneous or lacking a cohesive biological signature.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0060427","count":3},{"id":"GO:0060658","count":3},{"id":"GO:0010579","count":2},{"id":"GO:0045087","count":2}]},{"hash":"529435434228966942","title":"Skeletal development and ECM remodeling","description":"The top GO terms cluster around ossification (endochondral and intramembranous), collagen catabolic processes, and cadherin- and other cell\u2013cell adhesion, which together point to extracellular matrix remodeling during bone development. Immune-related complement activation terms appear but may reflect broader roles in development or incidental co-occurrence. A few terms (like glutamatergic synaptic transmission) are less directly connected, suggesting some noise, but the dominant pattern aligns with skeletal formation and matrix remodeling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0035987","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0001958","count":2},{"id":"GO:0001957","count":2}]},{"hash":"888228644813952256","title":"Endosome trafficking and actin-driven cell migration","description":"This cluster centers on endosomal transport to lysosomes, endosome organization, and lysosome localization, with supporting roles in actin cytoskeleton regulation, lamellipodium assembly, and polarity-driven cell migration, suggesting a coordinated vesicle trafficking and cytoskeletal remodeling program.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0032418","count":2},{"id":"GO:0032956","count":2},{"id":"GO:0071539","count":2}]},{"hash":"1348101989763997636","title":"Ubiquitination and Protein Degradation","description":"The dominant GO terms are about ubiquitination (poly-, mono-, and autoubiquitination) and the ubiquitin-dependent ERAD pathway, suggesting a shared role in tagging proteins for degradation; a few other terms refer to development or signaling but are less cohesive with the main theme, so the cluster most plausibly centers on ubiquitin-mediated protein regulation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060427","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0045433","count":1},{"id":"GO:0002028","count":1},{"id":"GO:0000209","count":1}]},{"hash":"1415565474141323994","title":"Chromatin regulation and nuclear organization","description":"This cluster is dominated by terms related to chromatin dynamics and transcription control, including negative regulation of transcription by RNA polymerase II, establishment of protein localization to chromatin, nucleus organization, DNA replication-dependent chromatin assembly, and rDNA/pericentric heterochromatin formation, plus sex-chromosome dosage compensation. These repeatedly point to chromatin remodeling and nuclear architecture as a unifying theme, with a few outliers (innate immune response in mucosa, midbrain morphogenesis) that may reflect broader roles or annotation overlap.","confidence":"High","size":21,"edges":205,"triangles":1239,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0071169","count":7},{"id":"GO:0002227","count":6},{"id":"GO:0006997","count":6},{"id":"GO:0007549","count":6}]},{"hash":"1929786793799605943","title":"Retroviral integration and latency","description":"The cluster is dominated by terms related to DNA replication, recombination, and especially DNA integration, with explicit references to viral entry into the nucleus and establishment of integrated proviral latency. The presence of RNA-templated DNA biosynthetic processes and negative regulation of siRNA processing further supports retrotranscription and interplay with RNA interference, all pointing to retroviral or retroelement\u2013mediated genome integration as the core theme. Some symmetry terms about symbionts appear, but the strongest signal centers on viral integration and latency.","confidence":"High","size":21,"edges":25,"triangles":7,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0006310","count":5},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4}]},{"hash":"1585845963579857554","title":"Unknown","description":"The GO terms span digestion, midbrain development, transcriptional regulation by RNA polymerase II (both positive and negative), amelogenesis, fibrinogen regulation, Toll signaling, and responses to yeast, with no clear unifying function or interaction pattern evident (no edges/triangles). There isn\u2019t a coherent theme tying these proteins together, so a specific label cannot be assigned with confidence.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007586","count":8},{"id":"GO:0030901","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0045944","count":8},{"id":"GO:1902947","count":7}]},{"hash":"445087163284146465","title":"Unknown","description":"The top GO terms span immune responses (complement activation, leukocyte migration), developmental/biomineralization themes (amelogenesis, biomineral tissue development), and endocytic/trafficking processes (receptor-mediated endocytosis, endosome localization) with an obsolete term present, suggesting no single cohesive function for this cluster.","confidence":"","size":21,"edges":20,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":5},{"id":"GO:0001867","count":4},{"id":"GO:0097186","count":3},{"id":"GO:2000483","count":3},{"id":"GO:1902966","count":3}]},{"hash":"302651426281996830","title":"Immune receptor signaling and phagocytosis","description":"Many top GO terms cluster around immune recognition and effector functions, including Fc-gamma receptor signaling, stimulatory C-type lectin receptor signaling, and phagocytosis recognition. While a few terms touch on development or other processes (platelet activation, lymph vessel morphogenesis, cartilage condensation), the dominant theme is immune cell signaling and phagocytic activity. This suggests the proteins in the cluster function together in immune receptor signaling and related phagocytic pathways. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0019933","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0036303","count":3}]},{"hash":"397326169502352053","title":"Unknown","description":"The terms span both general cellular processes (ribosome biogenesis, transcription regulation, glycosylation) and specific reproductive processes (mammary gland development, androgen/testosterone biosynthesis, sperm binding), with no connected interactions (Edges 0, Triangles 0). There isn\u2019t a single cohesive function tying the cluster together, so a meaningful specific label cannot be assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0006044","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0005989","count":2}]},{"hash":"2171332408189073577","title":"Unknown","description":"The terms span developmental processes (CNS development, lamellipodium morphogenesis, angiogenesis) and immune/host-microbe interaction (defense against bacteria, IL-2 production, T cell signaling, symbiont entry), with no single cohesive function tying all proteins together. Confidence: None","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":3},{"id":"GO:2000394","count":2},{"id":"GO:0045765","count":2},{"id":"GO:0046627","count":2},{"id":"GO:0042742","count":2}]},{"hash":"587822877904212701","title":"Neuroimmune Vision Signaling","description":"This cluster combines terms tied to visual perception and learning with neural signaling pathways (adrenergic receptor signaling, cAMP/Calcium signaling) and immune processes (inflammatory response, dendritic cell differentiation). The overlap suggests a neuroimmune theme where visual processing and sensory signaling intersect with immune activation and modulation.","confidence":"Medium","size":21,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0006955","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0043950","count":2},{"id":"GO:0001994","count":2}]},{"hash":"1024568811161526434","title":"Neuronal development and cytoskeletal signaling","description":"The cluster\u2019s GO terms center on neuronal morphogenesis and signaling, notably dendrite development and ephrin receptor signaling, plus cytoskeletal processes like filopodium assembly that underpin neurite outgrowth and projection formation. While a few terms touch on cell division or angiogenesis, the dominant theme is neuronal development and actin-based cell projections, suggesting these proteins collaborate in guiding neuronal growth and signaling during development.","confidence":"Medium","size":21,"edges":192,"triangles":1032,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0016358","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0043524","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0090051","count":2}]},{"hash":"542600467046697831","title":"Tissue development and ECM remodeling","description":"The cluster\u2019s GO terms point to developmental processes involving extracellular matrix and tissue remodeling, including larval chitin-based cuticle development (insect exoskeleton), collagen catabolic processes, ossification, and cell migration (keratinocytes, leukocytes) as well as vascular smooth muscle proliferation. Although the terms are diverse, they converge on growth, remodeling, and movement within tissues, suggesting a cohesive theme of developmental tissue formation and remodeling rather than a single narrow function.","confidence":"Medium","size":21,"edges":65,"triangles":79,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:1900122","count":1},{"id":"GO:0001503","count":1},{"id":"GO:0030574","count":1},{"id":"GO:0051549","count":1}]},{"hash":"1411107493604635494","title":"Chitin-based Cuticle Development and Metabolism","description":"The cluster shows a clear enrichment for chitin-associated processes, notably larval chitin-based cuticle development and chitin catabolic processes, suggesting a shared role in chitin metabolism and cuticle formation/remodeling. Other GO terms (ubiquitination, inflammatory mediator production, spore wall assembly, LPS biosynthesis) appear only once or twice and seem ancillary or due to cross-species annotations, so the dominant theme remains chitin-related biology.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0045493","count":1},{"id":"GO:0019428","count":1},{"id":"GO:0009245","count":1}]},{"hash":"337002654483901441","title":"Stress-Responsive RNA Processing","description":"The cluster shows links to stress responses (ischemia, hypoxia) along with post-transcriptional regulatory processes (alternative splicing regulation, mRNA polyadenylation, miRNA-mediated silencing). This suggests a group of proteins involved in RNA metabolism and translational control that is modulated under cellular stress.","confidence":"Medium","size":21,"edges":101,"triangles":312,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0002931","count":1},{"id":"GO:1903586","count":1},{"id":"GO:0035278","count":1},{"id":"GO:0071230","count":1},{"id":"GO:0045451","count":1}]},{"hash":"761902469426674726","title":"Larval chitin-based cuticle development","description":"This cluster is strongly driven by GO:0008363, with 14 proteins linked to larval chitin-based cuticle development, indicating a shared function in insect cuticle formation. The remaining GO terms are sparse and diverse, but the dominant signal points to cuticle synthesis and patterning in larvae.","confidence":"High","size":21,"edges":99,"triangles":230,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":14},{"id":"GO:2000769","count":1},{"id":"GO:0010310","count":1},{"id":"GO:2000353","count":1},{"id":"GO:0032005","count":1}]},{"hash":"2188871831277287757","title":"Developmental signaling regulators","description":"This cluster shows strong representation of developmental processes (heart, neuron, and multicellular organism development) along with signaling-related activities (MAPK, PI3K, phospholipase C) and regulatory processes (proteasomal ubiquitin-dependent protein catabolic process). The mix suggests proteins that participate in coordinating development through signaling pathways and related regulatory functions, with occasional adhesion and immune signaling connections that fit within broader developmental contexts.","confidence":"High","size":21,"edges":6,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":12},{"id":"GO:0032435","count":11},{"id":"GO:0048666","count":11},{"id":"GO:0010863","count":10},{"id":"GO:0000187","count":10}]},{"hash":"1839325548042597773","title":"Unknown","description":"The GO terms are highly disparate (DNA integration, proviral latency, apoptosis, GTPase regulation, dendrite development, translation), with no clear shared function or pathway. The lack of interactions (Edges 0) and lack of a unifying theme makes it inappropriate to assign a specific, cohesive label beyond Unknown.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0016358","count":2}]},{"hash":"663092390825664934","title":"Neural signaling and sensory organ development","description":"The terms cluster around neural connectivity and sensory structures (synapse organization, dendrite development, cochlea morphogenesis, vocalization behavior, receptor signaling). Receptor clustering and guanylyl cyclase signaling align with neural communication. A few items point to other tissues (endothelial barrier, renal transport), but the dominant signal is neural development and sensory organ function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":2},{"id":"GO:0090557","count":1},{"id":"GO:0007266","count":1},{"id":"GO:0050808","count":1},{"id":"GO:0006470","count":1}]},{"hash":"1715588934287921079","title":"Ubiquitin-regulated T cell and dendritic differentiation","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes and ubiquitination, paired with multiple terms about differentiation and regulation of immune cells (dendritic cells, Pro-T cells, memory T cells, germinal center formation, mast cells). While a couple of terms (phototropism, gravitropism) are plant-specific and may be noise, the dominant signal ties ubiquitin-mediated proteolysis to immune cell differentiation, justifying a label focused on that theme.","confidence":"Medium","size":21,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:1900477","count":4},{"id":"GO:2001200","count":4},{"id":"GO:0043380","count":4},{"id":"GO:0032764","count":4}]},{"hash":"1469992058877037401","title":"Neuronal signaling and synaptic plasticity","description":"This cluster combines terms for startle responses, ion channel\u2013mediated membrane transport (Na+/K+), regulation of synaptic transmission (glutamatergic), and synaptic plasticity, plus memory and sensory (lateral line) development in fish, suggesting proteins involved in neuronal signaling, synaptic regulation, and sensory system development.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0050806","count":3},{"id":"GO:0048915","count":3}]},{"hash":"1628790209539718180","title":"Adaptive and innate immune signaling and adhesion","description":"This cluster is dominated by immune-related GO terms: innate and adaptive immune response, B cell receptor signaling pathway, and cell adhesion, indicating coordination of immune signaling and leukocyte interactions. The regulation of Rho protein signaling fits with cytoskeletal changes underlying immune cell movement and immunological synapse formation. A heart development term is present but less representative; overall, the immune signaling theme best explains the cluster.","confidence":"Medium","size":21,"edges":9,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010863","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0045087","count":3}]},{"hash":"2114357317241114363","title":"Glutamatergic synapse signaling and plasticity","description":"The cluster is dominated by neuronal communication terms: glutamatergic synaptic transmission, excitatory postsynaptic potential, and regulation of synaptic transmission, along with short-term synaptic plasticity, plus memory and drug-response terms (long-term memory, response to amphetamine) that point to memory modulation. Some developmental terms may reflect tissue context rather than core function, but the core signal is synaptic signaling and plasticity.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0007616","count":3},{"id":"GO:0001975","count":3},{"id":"GO:0035249","count":3},{"id":"GO:0060079","count":3}]},{"hash":"1042512295650213330","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":52,"triangles":75,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1902416","count":6},{"id":"GO:0033129","count":5},{"id":"GO:0070935","count":5},{"id":"GO:0022013","count":4},{"id":"GO:0000398","count":4}]},{"hash":"1361586587612782652","title":"LPS- and cytokine-driven innate immune response","description":"Top terms are dominated by responses to lipopolysaccharide, IL-1 and TNF signaling, and necroptosis, indicating an innate immune/inflammatory program. While cholesterol homeostasis and axon regeneration are present, the core cluster centers on LPS/cytokine\u2013mediated immune signaling and regulated cell death.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0009615","count":3},{"id":"GO:0042632","count":3},{"id":"GO:0014012","count":2},{"id":"GO:0071347","count":2}]},{"hash":"2072312069028536202","title":"Vesicle trafficking and polarity regulation","description":"The terms cluster around endosome/lysosome transport, ER-to-Golgi vesicle transport, lipoprotein assembly, and establishment of epithelial cell polarity, all pointing to membrane trafficking and cargo sorting. Additional terms like podosome assembly and dendritic spine development suggest related cytoskeletal and structural organization tied to trafficking. While not perfectly cohesive, the common thread is regulation of vesicle transport and membrane organization, justifying this label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902824","count":3},{"id":"GO:0060999","count":3},{"id":"GO:1902307","count":3},{"id":"GO:1902953","count":3},{"id":"GO:1990386","count":3}]},{"hash":"1726251842185734704","title":"Unknown","description":"The top GO terms are highly heterogeneous, including apoptotic process, brain segmentation, DNA integration/recombination, and encapsulation of foreign targets, with several obsolete terms. There is no single coherent biological function or pathway that ties all 21 proteins together, and the lack of edges supports diverse annotations rather than a shared role. Therefore, a specific, representative name cannot be confidently assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0006486","count":4},{"id":"GO:0035284","count":4},{"id":"GO:0035010","count":4},{"id":"GO:0006049","count":4}]},{"hash":"1829316989835839426","title":"Adaptive immune signaling and lymphocyte differentiation","description":"The top GO terms cluster around adaptive immunity processes: B cell receptor signaling, dendritic cell and T cell differentiation, and germinal center formation, with related regulation of cytokine production and apoptosis. Despite an outlier term (phototropism) that does not fit immune biology, the dominant theme is signaling and differentiation within B/T cell lineages and germinal center activity.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0006915","count":3},{"id":"GO:1900477","count":2},{"id":"GO:2001200","count":2}]},{"hash":"922019599164289164","title":"Germline DNA Replication and piRNA Processing","description":"The cluster centers on germline-related DNA metabolism and genome defense: DNA replication, recombination, integration, transcription regulation, meiosis, and piRNA processing, suggesting a core theme of germline genome maintenance and transposon silencing. A few terms (dendritic cell differentiation, IGF signaling) are less aligned, acting as potential noise. Overall, the dominant signal supports a germline DNA processing theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0006310","count":2}]},{"hash":"520583894791113475","title":"Adrenergic GPCR-cAMP signaling and blood pressure regulation","description":"This cluster centers on adrenergic receptor\u2013mediated GPCR signaling that activates adenylate cyclase and increases cAMP, connected to norepinephrine/epinephrine\u2013driven vasoconstriction and regulation of systemic arterial blood pressure; the presence of inflammatory and mitochondrial terms appears more peripheral noise.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0015015","count":2},{"id":"GO:0030206","count":2}]},{"hash":"1785494648596291332","title":"Endochondral ossification and cartilage development","description":"The top GO terms cluster around skeletal connective tissue formation, especially cartilage development and endochondral ossification (endochondral ossification, growth plate chondrocyte development, cartilage condensation, tendon development) and related collagen signaling. A few terms touch other morphogenesis pathways, but the dominant theme is cartilage/bone development in skeletal morphogenesis.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":1},{"id":"GO:0071230","count":1},{"id":"GO:0003431","count":1},{"id":"GO:0060414","count":1},{"id":"GO:0038063","count":1}]},{"hash":"453744201919445607","title":"Glycan biosynthesis and fucosylation","description":"The dominant GO terms point to glycosylation and fucosylation processes (protein glycosylation, N-glycan fucosylation, Lewis a epitope biosynthesis, L-fucose catabolic process). Some additional terms touch on leukocyte migration and neuronal development, which can be influenced by glycan modifications, but the clearest shared function across the set is glycans and their modification. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0030501","count":2},{"id":"GO:0045910","count":1},{"id":"GO:0006298","count":1},{"id":"GO:0002522","count":1}]},{"hash":"1063686389832792600","title":"Cardiac and Skeletal Muscle Development","description":"The cluster is enriched with GO terms tied to heart development and cardiac muscle activity (atrial cardiac muscle cell action potential, heart development), skeletal system development and paraxial mesoderm development, plus signaling pathways (BMP signaling, ERK1/ERK2 cascade, Rho signaling) that regulate muscle and cardiac formation. Although a few terms pertain to neurogenesis, the overall pattern centers on development and signaling governing cardiac and skeletal muscle tissues, supporting a cohesive muscle-development theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086014","count":3},{"id":"GO:0048339","count":3},{"id":"GO:0022008","count":3},{"id":"GO:0030513","count":3},{"id":"GO:0048661","count":3}]},{"hash":"1180642641913382961","title":"Immune signaling and hematopoietic development","description":"The top GO terms point to both innate and adaptive immune responses, including B cell receptor signaling, along with megakaryocyte development, indicating a hematopoietic/immune cell\u2013focused cluster. Additional terms related to Rho signaling and cytoskeletal regulation (cell shape/polarity) support signaling dynamics typical of immune cells and hematopoietic lineages. A heart development term appears less central but may reflect shared developmental pathways. Overall, this cluster seems to center on immune signaling within hematopoietic lineages.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010863","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0045087","count":2}]},{"hash":"2116359744472367337","title":"RNA Polymerase II/III Transcription Initiation Machinery","description":"The top GO terms cluster around transcription initiation at RNA polymerase II and III promoters, preinitiation complex assembly, and promoter start-site selection, suggesting these proteins function collectively in transcription initiation. Viral transcription regulation terms appear as well, but the dominant theme is initiation machinery rather than a single other process.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001174","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0006367","count":1},{"id":"GO:0006384","count":1},{"id":"GO:0016032","count":1}]},{"hash":"637783831314162751","title":"Muscle and Skeletal Development Signaling","description":"Enriched terms cluster around developmental processes, especially those governing muscle and skeletal tissue formation (myoblast differentiation, skeletal system development, smooth muscle proliferation) and related signaling pathways (BMP signaling, ERK cascade). Cell adhesion supports tissue morphogenesis, and though some terms (lung alveolus development, myelination) extend to other tissues, they still reflect regulatory signaling during development, suggesting a cohesive theme of developmental signaling across tissues.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048286","count":2},{"id":"GO:0010761","count":2},{"id":"GO:0030513","count":2},{"id":"GO:0048661","count":2},{"id":"GO:0007155","count":2}]},{"hash":"866180488252372415","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":2},{"id":"GO:0046329","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0051083","count":1},{"id":"GO:0008363","count":1}]},{"hash":"680695048275862400","title":"Neurovascular development and signaling","description":"The top GO terms cluster around neuronal development and connectivity (positive regulation of synapse assembly, neuron migration, cell adhesion) and vascular development (angiogenesis, blood pressure regulation), with GPCR signaling pathways (adenylate cyclase-activating and phospholipase C-activating) linking signaling to these processes. The presence of an energy metabolism term (electron transport chain) adds a general cellular context but does not override the neurovascular/theme. Overall, these terms suggest proteins involved in coordinating neural development with vascular signaling. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0045777","count":5},{"id":"GO:0010579","count":5},{"id":"GO:0022900","count":5},{"id":"GO:0007156","count":4}]},{"hash":"1868679541911182571","title":"Ubiquitination-Regulated Immune Differentiation","description":"The top GO terms cluster around immune system development and differentiation (dendritic cells, T cells, germinal centers) and include regulation of protein ubiquitination, suggesting a theme of ubiquitin-mediated signaling shaping immune cell differentiation. A few terms (phototropism/gravitropism) are outliers, but the dominant signal supports this immune- and ubiquitin-centered function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":8},{"id":"GO:1900477","count":7},{"id":"GO:2001200","count":7},{"id":"GO:0043380","count":7},{"id":"GO:0032764","count":7}]},{"hash":"1970527852743478677","title":"Developmental Regulation and Stress Response","description":"This cluster centers on broad developmental processes (multicellular development, skeletal system development) and gene expression control (DNA-templated transcription, translation reinitiation, imprinting-related regulation), alongside stress and immune-related responses (ER-stress\u2013mediated apoptosis, cadmium response, defense against Gram-positive bacteria). The mixture suggests a theme around how development is coordinated with gene expression programs and cellular stress responses, rather than a single, narrow function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007584","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0050830","count":3}]},{"hash":"1193926423692877880","title":"Cardiac conduction and rhythm regulation","description":"The cluster is strongly enriched for cardiac electrical activity terms: AV node action potential, regulation of heart rate by cardiac conduction, ventricular repolarization, and atrial depolarization, which together point to heart rhythm and electrical signaling as the core theme. Other terms like development and ossification appear but do not override the dominant cardiac conduction signal. Confidence: High","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0086016","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0019233","count":5}]},{"hash":"129634576851904797","title":"Synaptic Organization and Neurotransmitter Uptake","description":"The cluster shows multiple GO terms centered on synapses and neurotransmission, including localization to the synapse, synapse organization, and uptake of dopamine and serotonin as well as glycine release during neurotransmission. This suggests a coherent theme of neuronal communication and synaptic maintenance. A couple of terms (e.g., skeletal system development) appear incidental, but do not override the main synaptic theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0035418","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0061537","count":1}]},{"hash":"10694957877158266","title":"Translation machinery and translational fidelity","description":"The dominant GO terms are related to aminoacyl-tRNA charging (ile, met, val, leu) and translation, including regulation of translational fidelity, which together point to the protein synthesis apparatus as the cluster's core function. A couple of fringe terms (Group I intron splicing and developmental processes) may reflect multifunctional proteins or annotation noise, but they do not override the main translation theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006428","count":2},{"id":"GO:0006431","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006438","count":2},{"id":"GO:0006429","count":2}]},{"hash":"1517543777804704195","title":"Axon guidance and neural signaling","description":"The top GO terms are dominated by neural development signals, especially axon fasciculation and axon extension, indicating a focus on axon guidance. Additional terms reflect neuronal signaling via GPCR\u2013PLC pathways and neuroendocrine responses (thyrotropin-releasing hormone), with a few immune-related signals (inflammatory response, I-kappaB phosphorylation). Overall, the cluster seems to center on neural development with associated signaling and some inflammatory cross-talk rather than a pure immune or purely neuronal set.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0007200","count":1}]},{"hash":"276176699521938163","title":"Unknown","description":"The top GO terms span very diverse processes\u2014from cuticle formation and spermatid differentiation to heart contraction, bone marrow proliferation, and angiotensin-related behaviors\u2014showing no clear, single biological theme tying all 21 proteins together. With no apparent shared pathway or function, a precise label isn\u2019t supported. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042395","count":2},{"id":"GO:0007289","count":2},{"id":"GO:0045663","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0060047","count":1}]},{"hash":"1184015179595866238","title":"Ras/Rho and Immune Signaling Regulation","description":"The top GO terms point to regulation of Ras and Rho signaling, immune signaling pathways (B cell receptor signaling; IL-2 production), as well as related phospholipid/IP3 signaling and integrin pathways. This suggests a coherent theme of coordinating diverse signal transduction processes, spanning cytoskeletal regulation and immune responses. While there are some obsolete terms, the overall pattern supports a shared regulatory signaling function rather than a single pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":6},{"id":"GO:0051092","count":6},{"id":"GO:0035023","count":5},{"id":"GO:0032959","count":5},{"id":"GO:0009395","count":5}]},{"hash":"2136321858163657988","title":"Apoptosis and DNA Damage Response Proteins","description":"The top GO terms are dominated by mitochondrial membrane permeability regulation and apoptotic process, alongside DNA repair activities (base-excision repair and double-strand break repair via NHEJ) and inflammatory response. This pattern suggests a cohesive role in cellular stress responses linking programmed cell death and genome maintenance, despite a few outlier terms likely representing broader cellular processes. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902108","count":1},{"id":"GO:0035289","count":1},{"id":"GO:0046011","count":1},{"id":"GO:0007427","count":1},{"id":"GO:0006915","count":1}]},{"hash":"1310525537840372392","title":"Neural development and neuron projection guidance","description":"This cluster is best described as Neural development and neuron projection guidance because the dominant GO terms refer to neuron development, neuron projections, neural crest migration, and nerve organization. A few terms involve cardiovascular development, which can relate to neural crest\u2013driven heart patterning, but the prevailing signal is nervous system development and connectivity.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021860","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0021591","count":1},{"id":"GO:2000020","count":1},{"id":"GO:0060976","count":1}]},{"hash":"347132319556239627","title":"Embryonic Development and Placental Differentiation","description":"Based on the top GO terms, the proteins cluster around embryonic development, especially placental lineage specification (trophoblast giant cell differentiation, placental development), left-right axis patterning, and various tissue morphogenesis events (cartilage formation, EMT in heart cushion). The presence of endocrine system and pancreatic cell development terms suggests broader embryogenesis and organogenesis. Ubiquitin-related regulation points to modulation of protein turnover during these developmental transitions, supporting a cohesive theme of early development and lineage differentiation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0060707","count":8},{"id":"GO:0060972","count":8}]},{"hash":"1458998814315969463","title":"Developmental signaling and lipid metabolism","description":"These proteins are linked to neural and placental development (brain development, endocrine system development, trophoblast differentiation, left-right pattern formation) and also to lipid-related processing and signaling (monoacylglycerol and triglyceride catabolism, phosphatidylserine catabolic process, regulation of endocannabinoid signaling, and GTPase activity regulation). The combination suggests a theme of developmental signaling that is modulated by lipid metabolism, justifying this label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0052651","count":3},{"id":"GO:2000124","count":3},{"id":"GO:0006660","count":3}]},{"hash":"234479260452010260","title":"Unknown","description":"These terms span diverse domains (blood development, cardiovascular function, gap junctions, hormone regulation, immune response, and insect cuticle development) with no clear unifying function or interaction pattern (the cluster has no edges), so a single coherent theme is not apparent.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030218","count":1},{"id":"GO:0055072","count":1},{"id":"GO:0060047","count":1},{"id":"GO:0071838","count":1},{"id":"GO:1903598","count":1}]},{"hash":"2205586627617338513","title":"Glutamatergic Synapses and Plasticity","description":"This cluster centers on excitatory glutamatergic synaptic transmission and activity-dependent plasticity, including excitatory postsynaptic potentials, short- and long-term plasticity (depression), and related neuronal functions like cerebellar granule cell differentiation and social behavior, with an additional note of morphine responsiveness suggesting modulation by opioid signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0050975","count":3},{"id":"GO:0048169","count":3},{"id":"GO:0048172","count":3},{"id":"GO:0043278","count":3}]},{"hash":"2152584567698429697","title":"Multi-tissue developmental signaling","description":"These proteins cluster around diverse developmental processes spanning plants (stomatal complex development) and animals (left ventricle formation, aorta morphogenesis, Notch signaling, hair cycle regulation, pancreatic endocrine fate). The common thread is activation of developmental signaling and organogenesis programs across multiple tissues, with Notch signaling highlighting a central developmental role. While the GO terms span varied organs, they collectively point to broad tissue differentiation and morphogenesis rather than a single specific function.","confidence":"Medium","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0010374","count":20},{"id":"GO:0045668","count":20},{"id":"GO:0032933","count":20},{"id":"GO:0035910","count":20},{"id":"GO:1900402","count":20}]},{"hash":"391316554088050345","title":"Stress-induced immune signaling and protein quality control","description":"The cluster\u2019s GO terms revolve around chaperone-mediated protein folding, detection of misfolded proteins, and protein complex assembly (protein quality control), with additional stress-related responses (ischemia, cocaine). There are also immune-related terms (B and T cell\u2013mediated responses) and a note on mitochondrial protein import, suggesting a module where cellular stress triggers quality-control pathways that interface with immune signaling. While cell cycle and telomere maintenance appear less central, the dominant themes are stress-induced protein QC and immune responses, supporting this label.","confidence":"Medium","size":20,"edges":103,"triangles":285,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":7},{"id":"GO:0045041","count":6},{"id":"GO:0051086","count":6},{"id":"GO:0002931","count":6},{"id":"GO:0007049","count":6}]},{"hash":"1558748590834699443","title":"Unknown","description":"The GO terms are too disparate to identify a single coherent function for the cluster, spanning brain development, transcription regulation, immune signaling, enamel formation, fibrinogen regulation, and more, with no clear unifying theme.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":7},{"id":"GO:0000122","count":6},{"id":"GO:1902947","count":5},{"id":"GO:0097186","count":5},{"id":"GO:0044537","count":5}]},{"hash":"977794740957385602","title":"Innate Immune Response and Inflammation","description":"The top GO terms cluster around innate immunity and inflammatory processes: responses to LPS and yeast, neutrophil activity and leukocyte migration, and Toll signaling. Coagulation-related terms (plasminogen activation and fibrinogen regulation) often intersect with inflammation, reinforcing a theme of inflammatory/immune activation. Some terms are obsolete or incidental (amylogenesis-related), but the core signal is clearly innate immune response and inflammation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001878","count":10},{"id":"GO:0032496","count":10},{"id":"GO:1902947","count":9},{"id":"GO:0097186","count":9},{"id":"GO:0044537","count":9}]},{"hash":"1073731981432451282","title":"Inflammation-Driven Tissue Remodeling and Development","description":"The GO terms point to inflammatory response coupled with a broad set of developmental and remodeling processes (megakaryocyte development, mammary gland involution and epithelial proliferation regulation, mesenchymal apoptosis, intestinal epithelial development, ectodermal fate commitment) and transcriptional/miRNA regulation, suggesting a cluster of proteins involved in inflammation-associated remodeling across tissues rather than a single, narrow pathway.","confidence":"Medium","size":20,"edges":4,"triangles":1,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0035855","count":3},{"id":"GO:0060056","count":2},{"id":"GO:0033600","count":2}]},{"hash":"1731247023239532949","title":"Energy metabolism and translation","description":"The cluster is dominated by GO terms related to energy production, including photosynthesis light reaction, ATP synthesis coupled electron transport, and mitochondrial electron transport NADH to ubiquinone, suggesting a core theme of cellular energy generation. The presence of translation indicates concurrent involvement in protein synthesis, so the proteins may be multifunctional or part of energy-intensive cellular processes. Overall, the cluster centers on energy metabolism with a supporting role for translation.","confidence":"Medium","size":20,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019684","count":3},{"id":"GO:0042773","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0006810","count":2}]},{"hash":"1107467229690375546","title":"Unknown","description":"The GO terms span very diverse areas: midbrain development, amelogenesis, transcriptional regulation, coagulation/fibrinolysis (fibrinogen regulation, plasminogen activation), and innate immune signaling with neutrophil antifungal activity. The mix, plus several obsolete terms, does not reveal a single cohesive function that characterizes the entire protein set. Because there is no clear unifying theme, the cluster cannot be confidently assigned a specific biological role.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":8},{"id":"GO:0000122","count":8},{"id":"GO:1902947","count":7},{"id":"GO:0097186","count":7},{"id":"GO:0044537","count":7}]},{"hash":"862964634953615824","title":"Placental vascular development","description":"Based on the enrichment of terms related to angiogenesis, VEGF receptor signaling, mesoderm formation, and placenta development, the proteins most likely participate in embryonic placental vascular development. While some other terms (defense response, DNA repair) appear, the dominant pattern centers on vascular growth and placental formation. This makes a concise label of Placental vascular development appropriate and representative.","confidence":"High","size":20,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0014068","count":5},{"id":"GO:0071333","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0048010","count":5}]},{"hash":"365422933756811510","title":"Musculoskeletal and cuticle development","description":"The top GO terms cluster around developmental processes, including larval cuticle formation, skeletal/cartilage development, BMP signaling, myoblast differentiation, and cell adhesion, suggesting a shared role in tissue morphogenesis and differentiation across muscle, skeleton, and integumentary structures.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0032091","count":2},{"id":"GO:0090197","count":2}]},{"hash":"719682521553376045","title":"Neural and Muscle Development with Chromatin Regulation","description":"The cluster centers on tissue-specific development (skeletal muscle, substantia nigra, retina) and broad regulation of gene expression tied to chromatin remodeling (histone exchange/acetylation, heterochromatin formation), with supporting roles in mitochondrial localization and endocytosis, indicating a cohesive developmental program governed by chromatin Regulation.","confidence":"Medium","size":20,"edges":187,"triangles":1089,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":14},{"id":"GO:0021762","count":14},{"id":"GO:0010628","count":13},{"id":"GO:0051654","count":13},{"id":"GO:0030100","count":13}]},{"hash":"686689712441530349","title":"Larval chitin-based cuticle development","description":"This cluster's proteins are strongly associated with larval chitin-based cuticle development (GO:0008363), indicating a module of genes involved in forming and maturing the larval cuticle via chitin synthesis. The dominant GO term and cohesive clustering support a cohesive functional group focused on insect cuticle biology.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":20}]},{"hash":"2222634961971480867","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044376","count":1},{"id":"GO:0007064","count":1},{"id":"GO:1990022","count":1},{"id":"GO:0034087","count":1},{"id":"GO:0031440","count":1}]},{"hash":"1363315985318463470","title":"Insect cuticle development and morphogenesis","description":"This cluster is dominated by chitin-based cuticle development terms, especially larval cuticle formation and general cuticle development (GO:0040003 with 6 proteins; GO:0008363 with 3; GO:0010171 body morphogenesis with 6), pointing to exoskeleton biosynthesis during insect development. Additional terms like chitin catabolic process and carbohydrate metabolic process support a developmental and metabolic role, while a few immune/reproductive terms appear as secondary associations. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":6},{"id":"GO:0010171","count":6},{"id":"GO:0008363","count":3},{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2}]},{"hash":"1422495850832460835","title":"Plant cell wall biosynthesis and pollen exine formation","description":"The top GO terms cluster around plant cell wall construction and related polysaccharide biosynthesis (plant-type secondary cell wall biogenesis, glucuronoxylan biosynthesis, pollen exine formation, and general cell wall organization). While several proteoglycan biosynthesis terms appear, these likely reflect cross-annotated pathways or conserved motifs, but the dominant signal is plant cell wall polysaccharide production and pollen wall formation. ","confidence":"High","size":20,"edges":35,"triangles":29,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":3},{"id":"GO:0050650","count":3},{"id":"GO:0050651","count":3},{"id":"GO:0015012","count":3},{"id":"GO:0030204","count":3}]},{"hash":"1099110830109862205","title":"Developmental Morphogenesis Across Tissues","description":"The top GO terms point to diverse development-related processes across multiple tissues (nervous system development, cardiac formation, diaphragm development, stomatal development), suggesting a general theme of organogenesis/morphogenesis rather than a single specific pathway. Some terms like filopodium assembly and SREBP signaling relate to cell morphology and regulation, but the overall signal supports broad developmental roles across different organisms. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0060539","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0021762","count":2}]},{"hash":"167549003659222558","title":"Unknown","description":"The proteins in this cluster show a highly diverse set of GO terms\u2014from neural signaling (regulation of AMPA receptor activity, positive regulation of synaptic transmission) to development (larval cuticle, amelogenesis), bone remodeling (osteoclast differentiation/development), vascular migration, and other processes. There is no clear, cohesive functional theme connecting these terms, so a single interpretable label isn\u2019t supported. ","confidence":"","size":20,"edges":101,"triangles":267,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:2000311","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0050806","count":1},{"id":"GO:0097186","count":1},{"id":"GO:0045671","count":1}]},{"hash":"449692042622648803","title":"Unknown","description":"The top terms are highly diverse (cell cycle regulation, estrogen receptor signaling, IgG isotype switching, histone demethylation, chorion development) with no clear shared pathway or function, and there are no edges connecting proteins, so no cohesive biological theme emerges. Confidence: None","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902808","count":1},{"id":"GO:0033148","count":1},{"id":"GO:0048304","count":1},{"id":"GO:0071557","count":1},{"id":"GO:0060717","count":1}]},{"hash":"36920243658241855","title":"Organelle inheritance and cytoskeletal organization","description":"The top terms cluster around inheritance of organelles (mitochondrion, vacuole, Golgi, peroxisomes) and related cytoskeletal/polarity processes (actin patches, spindle orientation), indicating a cohesive theme of organelle inheritance and cell architecture. A noise term for sensory perception of sound appears but is not central to the cluster's core function.","confidence":"High","size":20,"edges":47,"triangles":86,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071963","count":8},{"id":"GO:0000001","count":7},{"id":"GO:0000147","count":7},{"id":"GO:0000011","count":7},{"id":"GO:0000132","count":7}]},{"hash":"426850538510135056","title":"Neural synapse dynamics and behavior regulation","description":"The cluster is dominated by GO terms related to neural function and behavior (social behavior, vocalization, grooming regulation, dendritic spine morphogenesis, receptor clustering, and long-term synaptic depression), indicating a core theme of synapse structure/dynamics modulating behavior. A couple of terms are less central (endothelial barrier establishment, centrosome localization), but they do not override the prevailing neuronal/synaptic signal.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0090557","count":2},{"id":"GO:0007266","count":2}]},{"hash":"676600054467498924","title":"Neuronal plasticity and learning","description":"The top GO terms cluster around neural function and synaptic modification\u2014long-term memory, visual learning, long-term potentiation/depression, social behavior, and ERK signaling\u2014suggesting the proteins act in neuronal signaling and synaptic plasticity. Peripheral terms like heart development or sodium transport are less defining, so the core theme remains neural plasticity.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007616","count":3},{"id":"GO:0035725","count":3}]},{"hash":"44669052052175566","title":"Embryonic lens and craniofacial morphogenesis","description":"The cluster\u2019s top GO terms cluster around developmental and morphogenetic processes, especially eye lens development (lens fiber cell differentiation, lens morphogenesis) and craniofacial structures (embryonic cranial skeleton morphogenesis, palate development), with additional signals related to broader organogenesis (midbrain, ventricular septum, myocardium). This suggests a cohesive theme of embryonic tissue morphogenesis centered on the eye and craniofacial region.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0003350","count":2},{"id":"GO:0030901","count":2}]},{"hash":"101757140113829913","title":"Ribosome biogenesis and translation with trafficking","description":"The cluster centers on ribosome biogenesis, cytoplasmic translation, and SRP-dependent cotranslational targeting to membranes, plus intracellular protein transport, indicating core roles in protein synthesis and targeting. Additional terms related to vesicle coating and endocytosis fit with broader trafficking of proteins. A few terms (interleukin-4 response, NF-kappaB signaling, sebaceous gland development) are less cohesive. Overall, the dominant theme is ribosome function and protein sorting/trafficking.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071353","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006614","count":1},{"id":"GO:0000027","count":1}]},{"hash":"1889602879016816233","title":"Neuronal projection and synapse development","description":"Based on the top GO terms, the cluster is enriched for neuronal development and connectivity processes: neuron projection development, synapse organization, actin cytoskeleton organization, and regulation of Rho signaling\u2014which together govern growth cone dynamics, cytoskeletal remodeling, and synapse formation. While other terms indicate broader developmental processes, the dominant signal centers on neuronal maturation and synaptic architecture, justifying this label.","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0009268","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0030036","count":2}]},{"hash":"1920481115917275331","title":"Glycan biosynthesis and cell surface glycosylation","description":"Top GO terms indicate a theme of glycan production and modification of cell surfaces, including plant cell wall biosynthesis (glucuronoxylan, plant-type secondary cell wall biogenesis) and various glycosylation processes (Lewis a epitope biosynthesis, poly-N-acetyllactosamine, O-linked glycosylation). The overlap with cell adhesion and epithelial polarity concepts suggests these proteins contribute to extracellular matrix and cell-surface structures across species. Thus, a concise label focusing on glycan biosynthesis and glycosylation best captures the cluster\u2019s core functions.","confidence":"Medium","size":20,"edges":110,"triangles":233,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071555","count":6},{"id":"GO:0009834","count":5},{"id":"GO:0010417","count":5},{"id":"GO:0007299","count":5},{"id":"GO:0010493","count":5}]},{"hash":"1906194646406194193","title":"Broad signaling and regulatory processes","description":"The proteins in this cluster appear linked to a range of signaling and regulatory roles across different tissues and systems, including GPCR-related signaling, endothelial proliferation in angiogenesis, cardiac cell communication, hormone secretion (vasopressin), and general regulatory activities (cell cycle, post-translational modification, immune signaling, and neural processes). Rather than a single pathway or function, the common theme is involvement in broad regulatory/signaling activities across multiple organ systems, justifying a broad label rather than a more specific one.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:1903589","count":3},{"id":"GO:0086070","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0030103","count":3}]},{"hash":"2221840349151806905","title":"GTPase signaling and ubiquitin-mediated regulation","description":"The top GO terms point to GTPase-related signaling (positive regulation of GTPase activity, GPCR signaling) and protein turnover processes (ubiquitination, ERAD). Together these suggest a cluster focused on signal transduction via G proteins coupled to proteostasis mechanisms, rather than a single developmental or metabolic outcome. Some terms are outliers or deprecated, but the core theme centers on signaling with concurrent regulation of protein stability.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0001501","count":6},{"id":"GO:0070208","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0030433","count":6}]},{"hash":"518912021712724561","title":"Apoptosis and Protein Homeostasis Regulation","description":"This cluster centers on negative regulation across stress-related protein handling and apoptosis pathways: negative regulation of ubiquitination and protein refolding, plus extrinsic apoptotic signaling components. A few terms touch plant development or obsolete transcription regulation, but the common thread appears to be control of apoptosis and protein quality control under cellular stress. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":2},{"id":"GO:0071260","count":1},{"id":"GO:0042993","count":1},{"id":"GO:0061084","count":1},{"id":"GO:0010664","count":1}]},{"hash":"871531697526164786","title":"Adrenergic/Dopaminergic GPCR Signaling in Heart and Immunity","description":"The cluster is dominated by GO terms for adrenergic and dopamine receptor signaling, cAMP/GPCR pathways, and vasoconstriction, with links to heart development and inflammatory/dendritic cell differentiation. This suggests a cohesive module of GPCR-mediated signaling impacting cardiovascular function and immune cell behavior.","confidence":"High","size":20,"edges":81,"triangles":125,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":19},{"id":"GO:0001994","count":19},{"id":"GO:0051482","count":19},{"id":"GO:0006954","count":19},{"id":"GO:0071880","count":19}]},{"hash":"2003324229182699462","title":"Unknown","description":"The top GO terms span highly diverse processes\u2014from Wnt signaling and endothelial angiogenesis to cardiac conduction, cell cycle, neuroendocrine secretion, neural differentiation, apoptosis, PARP activity, nociception, and immune regulation. There isn't a single cohesive biological theme that ties these terms together, suggesting functional heterogeneity rather than a specific, shared function for this cluster.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":4},{"id":"GO:1903589","count":3},{"id":"GO:0086070","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0030103","count":3}]},{"hash":"847366329492997058","title":"Unknown","description":"No shared GO terms or interactions are reported, and with edges/triangles at zero there is no evidence of a common function. Therefore, the cluster cannot be assigned a specific label.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1362222152693862080","title":"Tissue Development and Morphogenesis","description":"These proteins show a pattern centered on tissue development and morphogenesis across multiple systems (cuticle and bone formation, kidney tubule morphogenesis, lymph vessel formation). Supporting terms include chitin metabolism and protease regulation related to remodeling during development. The inflammatory mediator and chemokine terms are present but appear ancillary to the main morphogenesis theme. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0010951","count":3},{"id":"GO:0072237","count":2},{"id":"GO:0036303","count":2},{"id":"GO:0072287","count":2}]},{"hash":"730637735742289813","title":"Chitin-based cuticle development and metabolism","description":"The top GO terms are heavily centered on chitin catabolic process and chitin-based cuticle development (including larval cuticle), plus general carbohydrate metabolism. This points to a cohesive functional theme of chitin remodeling and cuticle formation in insects, consistent with molting and development. While other terms related to inflammatory responses and neural processes appear, they are less representative of the cluster\u2019s core function compared to the chitin/cuticle terms.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":3},{"id":"GO:0002532","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0040003","count":2}]},{"hash":"942032195509636298","title":"Developmental signaling and cardiac conduction","description":"The cluster features GO terms centered on development (multicellular organism development, skeletal system development) and key signaling pathways (Smoothened/Hedgehog), plus cardiac electrophysiology terms (AV node action potential, regulation of heart rate by cardiac conduction, ventricular repolarization). While some immune-related terms appear, the dominant theme ties developmental signaling to heart function, suggesting a cluster of developmental signaling processes with cardiac conduction implications.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":2},{"id":"GO:0097211","count":2},{"id":"GO:1905065","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0006958","count":2}]},{"hash":"741210617692398691","title":"Proviral integration and latency","description":"The top terms strongly point to processes that integrate viral or mobile genetic elements into host DNA (DNA integration, DNA transposition, retrotransposition) and establish latent proviruses. Additional terms reference viral entry and host-symbiont interactions, as well as host responses (interferon-alpha) and regulation of viral replication, plus translation. Together, these terms signify a cluster centered on viral genome integration/latency and associated host interactions, rather than a single metabolic pathway.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0075732","count":2}]},{"hash":"1008035335257802057","title":"Unknown","description":"The Top Terms include antiviral defense, ubiquitin-dependent protein degradation, several plant carbohydrate metabolic processes, neuronal development, lipid catabolism, and a sperm zona pellucida penetration term, with no clear shared function tying them together. There are no observed edges or cohesive interactions, suggesting no single cohesive theme for the cluster.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0045493","count":1},{"id":"GO:0021680","count":1},{"id":"GO:0030244","count":1}]},{"hash":"454448377586907631","title":"Glycoprotein-mediated follicular epithelial adhesion and polarity","description":"The top GO terms cluster around follicle epithelium adhesion and maintenance of epithelial polarity, coupled with glycosylation and glycan biosynthesis processes. This suggests a cohesive role for glycoprotein-mediated extracellular interactions in epithelial morphogenesis, particularly in the insect follicular epithelium, with broader nods to related glycosylation pathways and morphogenetic processes. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007299","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0007519","count":2}]},{"hash":"3404056251728312","title":"Adrenergic GPCR\u2013cAMP signaling and blood pressure regulation","description":"These proteins are centered on adrenergic GPCR signaling that activates adenylyl cyclase and modulates cAMP and calcium signaling, fitting with vascular effects like norepinephrine/epinephrine\u2013driven vasoconstriction and blood pressure regulation. While there are additional terms related to inflammation and dendritic cell differentiation that are less central, the dominant theme is adrenergic receptor\u2013cAMP signaling linked to vascular tone. Confidence: High","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":6},{"id":"GO:0022900","count":6},{"id":"GO:0045777","count":6},{"id":"GO:0043950","count":5},{"id":"GO:0001994","count":5}]},{"hash":"2074924533883301036","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048286","count":1},{"id":"GO:1902035","count":1},{"id":"GO:0032973","count":1},{"id":"GO:1990034","count":1},{"id":"GO:0097624","count":1}]},{"hash":"2028605291665650001","title":"Organogenesis and neural development with immune signaling","description":"The cluster combines terms tied to organ formation (multicellular development, heart development, organ induction, ossification) with neural patterning (trigeminal nerve organization, axon guidance) and immune activity (adaptive immune response, phagocytosis). This points to a broad developmental program coordinating organogenesis and nervous system formation, with concurrent immune signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0021637","count":3},{"id":"GO:0035584","count":3},{"id":"GO:1902287","count":3}]},{"hash":"1769097218388465001","title":"Thymus development and T cell selection","description":"This cluster is driven by thymus-related terms, including regulation of positive thymic T cell selection, lymphoid lineage migration into the thymus, and thymus epithelium morphogenesis, suggesting a cohesive role in thymic development and T cell education. A minority of terms reference RNA splicing and nucleolar localization, which may reflect ancillary housekeeping functions or annotation noise; overall, the thymic theme dominates.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902232","count":2},{"id":"GO:0097535","count":2},{"id":"GO:0097536","count":2},{"id":"GO:0008380","count":1},{"id":"GO:1904751","count":1}]},{"hash":"550716151193306843","title":"Fatty acid and sphingolipid biosynthesis","description":"The set is dominated by GO terms for lipid production, including fatty acid elongation (long-chain, polyunsaturated, monounsaturated), unsaturated fatty acid biosynthesis, and sphingolipid biosynthetic process, plus long-chain fatty-acyl-CoA biosynthesis. A secondary signal is post-Golgi vesicle-mediated transport, which can relate to lipid/secretory trafficking. The presence of pheromone metabolic process and courtship behavior suggests possible lipid-derived signaling roles, and swim bladder development hints at a vertebrate (fish) context, though the core theme remains lipid biosynthesis with potential signaling ties.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030148","count":2},{"id":"GO:0034625","count":2},{"id":"GO:0006892","count":2},{"id":"GO:0042759","count":2},{"id":"GO:0007619","count":2}]},{"hash":"253179013947295082","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046963","count":1},{"id":"GO:1990569","count":1},{"id":"GO:0036085","count":1},{"id":"GO:0034221","count":1},{"id":"GO:0072334","count":1}]},{"hash":"693068012083889","title":"Neural crest migration and axon guidance","description":"This cluster is dominated by GO terms tying neural crest cell migration (ventral trunk neural crest), various axon guidance processes (sympathetic neuron projection guidance/extension, branchiomotor neuron axon guidance, trigeminal nerve organization, axonal fasciculation) and semaphorin-plexin signaling\u2014together pointing to neural crest\u2013derived neural development and axon pathfinding, with heart development likely reflecting neural crest contributions. Proteolysis may reflect extracellular remodeling during migration and guidance, but the core theme is neural crest\u2013driven neural development and axon guidance.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036486","count":2},{"id":"GO:0048168","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0097491","count":2},{"id":"GO:0097490","count":2}]},{"hash":"2025689201512541085","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms related to neuron development and axon-related processes (axogenesis, neuron projection development, sympathetic and trigeminal nerve guidance, neural crest migration). While a couple terms touch broader developmental contexts (ventricular system, coronary vasculature), the central theme is neural development and the formation of neuronal projections, justifying a neural-specific label.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060385","count":2},{"id":"GO:0021860","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0021591","count":1},{"id":"GO:2000020","count":1}]},{"hash":"465586660702330151","title":"Developmental organogenesis and transcription regulation","description":"The GO terms point to broad developmental processes across multiple tissues (midbrain, pancreas, biomineral/digestive tissues; post-embryonic development) and both positive and negative regulation of transcription by RNA polymerase II, suggesting proteins that coordinate transcriptional control during organogenesis and tissue development. The presence of terms like amelogenesis and leukocyte migration further supports a general developmental regulatory role rather than a single-tissue function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0035264","count":9},{"id":"GO:0030901","count":8},{"id":"GO:0061113","count":8},{"id":"GO:0009791","count":8}]},{"hash":"2146358092619273315","title":"Neuronal development and inhibitory synapse organization","description":"This cluster is enriched for terms tied to neural development and synaptic function, including neuroblast differentiation, inhibitory synapse assembly, postsynaptic density clustering, synaptic vesicle clustering, and positive regulation of inhibitory postsynaptic potential. The retina development term supports a neural tissue context, while the other terms point to the formation and modulation of inhibitory synapses, suggesting a cohesive theme around neuronal maturation and synaptic organization.","confidence":"High","size":19,"edges":122,"triangles":478,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":7},{"id":"GO:0002076","count":6},{"id":"GO:0002087","count":6},{"id":"GO:1904862","count":6},{"id":"GO:0006366","count":5}]},{"hash":"1193684606339078702","title":"DNA replication and cell division","description":"Top GO terms are dominated by DNA replication and mitotic cell cycle, suggesting a cluster of proteins involved in genome duplication and chromosome segregation. Supporting terms like iron-sulfur cluster assembly and protein heterooligomerization align with replication machinery, while the symbiont entry into host cells appears as a potential outlier.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1395373735634066092","title":"Unknown","description":"The GO terms are highly heterogeneous, including immune cell differentiation (dendritic cell, T cell, germinal center formation, mast cell cytokine regulation) and non-immune processes (skeletal muscle development, phototropism, gravitropism). With no consistent shared function and no edges to support a common pathway, there isn\u2019t a clear cohesive theme for this cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":7},{"id":"GO:2000312","count":6},{"id":"GO:1900477","count":5},{"id":"GO:2001200","count":5},{"id":"GO:0043380","count":5}]},{"hash":"22598919698808578","title":"Developmental transcriptional regulators","description":"The top GO terms indicate involvement in transcriptional regulation and diverse tissue development (cartilage, skeletal muscle, palate, midbrain, pancreatic cells, etc.), suggesting these proteins are transcriptional regulators guiding developmental programs across multiple tissues rather than a single tissue-specific function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0051216","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0003323","count":4}]},{"hash":"977930917215897775","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0000480","count":3}]},{"hash":"1126147045339163288","title":"Unknown","description":"The top GO terms are spread across transcription, RNA processing, ribosome biogenesis, ubiquitination, and broad developmental/immune processes, with no single shared pathway tying them together. This suggests a mixed or artifactual cluster rather than a coherent functional module.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0000209","count":3},{"id":"GO:0000398","count":3}]},{"hash":"1574699528335402405","title":"Neuronal development and synaptic organization","description":"The top terms are dominated by nervous system development, synapse organization, axon extension, and myelination, suggesting a cluster of proteins involved in neural structure and connectivity. While there are a few outlier terms (e.g., sarcomere organization, NK cell activation, and insect-specific morphogenesis), the prevailing signal points to neuronal development and synaptic assembly as the core theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051092","count":14},{"id":"GO:0035023","count":12},{"id":"GO:0050808","count":12},{"id":"GO:0048803","count":12},{"id":"GO:0046718","count":12}]},{"hash":"2066225189393236028","title":"Inflammation and tissue remodeling","description":"This cluster shows immune/inflammatory signals (cellular response to LPS, complement activation, regulation of cytokine production, NF-kappaB-related term) alongside tissue development and remodeling processes (uterus development, maintenance of GI epithelium, neurogenesis, collateral sprouting, focal adhesion dynamics, xenobiotic response). The combination suggests proteins involved in inflammatory responses that interface with tissue maintenance and remodeling rather than a single pathway, hence a label centered on inflammation and remodeling is most representative.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0060065","count":5},{"id":"GO:1900016","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0030277","count":4}]},{"hash":"1201161147048472533","title":"Neural development and signaling pathways","description":"The dominant GO terms point to neural and brain development and multiple signaling cascades (Rho signaling, Slit/Robo, Hedgehog/Smoothened) that guide neural differentiation, axon guidance, and synaptic function. While some terms relate to broader development (myoblast fusion, kidney development), the strongest enrichment centers on nervous system development and neuronal signaling.","confidence":"High","size":19,"edges":41,"triangles":43,"max_degree":13,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":13},{"id":"GO:0007520","count":11},{"id":"GO:0007224","count":11},{"id":"GO:0007399","count":11},{"id":"GO:0035385","count":11}]},{"hash":"62690095855882341","title":"Unknown","description":"The Top Terms are quite diverse, spanning energy metabolism (aerobic respiration, ATP synthase complex assembly, menaquinone/biotin biosynthesis) as well as transcription regulation, RNA modification (rRNA methylation), and various chemical-response processes. There isn\u2019t a single coherent biological theme that ties all these terms together, so a concise, representative label isn\u2019t evident.","confidence":"","size":19,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0033615","count":2},{"id":"GO:0051591","count":2},{"id":"GO:0019505","count":1}]},{"hash":"2018921862570049477","title":"Gene Expression Machinery and Ribosome Biogenesis","description":"The cluster is dominated by GO terms for ribosome biogenesis, translation, and DNA-templated transcription/termination by RNA polymerase II, pointing to core gene expression processes. Additional terms reflect proteostasis (chaperone-mediated assembly), translation fidelity, and mitochondrial protein import, suggesting a cohesive module centered on transcription-translation machinery and ribosome assembly. ","confidence":"High","size":19,"edges":169,"triangles":936,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0006369","count":2}]},{"hash":"1194981319982508292","title":"Ubiquitin-Proteasome Regulation of Cell Cycle","description":"The top terms cluster around ubiquitin tagging and proteasome-dependent protein degradation (SCF- and APC/C-mediated pathways, K11-linked ubiquitination, autoubiquitination, ERAD), tightly tying to cell-cycle control (G2/M transition, anaphase-promoting complex activity). Additional terms like neddylation support ubiquitin ligase function, while other items (viral process, peroxisomal import, DNA repair) appear secondary or indirect. Overall, the dominant theme is ubiquitin-proteasome\u2013driven regulation of the cell cycle.","confidence":"High","size":19,"edges":169,"triangles":936,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":18},{"id":"GO:0070979","count":17},{"id":"GO:0016032","count":16},{"id":"GO:0030433","count":16},{"id":"GO:0051865","count":16}]},{"hash":"94250652395034850","title":"Larval chitin-based cuticle development","description":"The single highly enriched GO term (GO:0008363) directly points to larval chitin-based cuticle formation, suggesting the proteins cluster around cuticle biosynthesis/remodeling during larval development.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":19}]},{"hash":"1702178047438934770","title":"Unknown","description":"The GO terms are a diverse mix from different kingdoms (insect cuticle development, plant stomatal development, vertebrate heart formation, Notch signaling, hair cycle, etc.) with little cohesive functional theme beyond broad developmental regulation. This lacks a clear, single biological process linking the cluster, so a specific label isn\u2019t supported.","confidence":"","size":19,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":10},{"id":"GO:0010374","count":1},{"id":"GO:0045668","count":1},{"id":"GO:0032933","count":1},{"id":"GO:0035910","count":1}]},{"hash":"1087519120803145946","title":"Chitin-based cuticle development and morphogenesis","description":"This cluster is dominated by GO terms for chitin-based cuticle development (larval and general) and chitin catabolic process, with supporting terms for body morphogenesis and cell-matrix adhesion, suggesting a cohesive role in cuticle formation/remodeling and tissue shaping; inflammatory mediator and chemokine terms may reflect remodeling contexts rather than a core function. ","confidence":"Medium","size":19,"edges":15,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0040003","count":3},{"id":"GO:0010171","count":3},{"id":"GO:0006032","count":2}]},{"hash":"169709129061390244","title":"Unknown","description":"Top terms point to two unrelated processes: male courtship behavior/wing song production and regulation of sodium ion transport. With only one instance for each term and no edges or network connectivity, there is no coherent shared function tying this cluster together. Therefore, Unknown with confidence None.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045433","count":1},{"id":"GO:0002028","count":1}]},{"hash":"1241928503929905701","title":"Larval cuticle development and tissue morphogenesis","description":"The dominant GO term is larval chitin-based cuticle development, which strongly anchors the cluster to insect cuticle formation. Additional terms point to broader developmental processes across tissues (organ morphogenesis, differentiation regulation, synapse formation, and cell adhesion) and signaling responses (TGF-beta, heparin). Together, these suggest a cohesive theme of developmental differentiation and morphogenesis in multiple tissues, centered on larval cuticle biology. ","confidence":"High","size":19,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0046533","count":3},{"id":"GO:0060956","count":3},{"id":"GO:0071504","count":3},{"id":"GO:0045662","count":3}]},{"hash":"1757818935557704701","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0055012","count":2}]},{"hash":"222106287111935050","title":"Cardiac and Skeletal Muscle Contraction Regulation","description":"The top GO terms cluster around muscle contraction and its regulation, including cardiac-specific processes such as ventricular cardiac muscle tissue morphogenesis and cardiac contraction, as well as skeletal muscle activities like muscle filament sliding and fiber-type transitions. The mix of positive and negative regulation of ATP-dependent activity and regulation of muscle contraction supports a cohesive theme of contraction control in striated muscle across heart and skeletal tissue. Therefore, this cluster is best described as Cardiac and Skeletal Muscle Contraction Regulation.","confidence":"High","size":19,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043057","count":5},{"id":"GO:0032780","count":5},{"id":"GO:0060048","count":5},{"id":"GO:0055010","count":5},{"id":"GO:0045932","count":5}]},{"hash":"702840053600901417","title":"Membrane Transporters","description":"The GO terms are dominated by transmembrane transport of ions (K+, Na+), metabolites (galactose, nitrate/nitrite, vitamin, fucose), and xenobiotics, plus a process for loading neurotransmitters into synaptic vesicles, pointing to a cluster of proteins that move substances across membranes and include ion carriers, transporters, and vesicular transport components.","confidence":"High","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":7},{"id":"GO:0035725","count":5},{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0015757","count":3}]},{"hash":"2253579355181455337","title":"Unknown","description":"The set of GO terms includes transepithelial chloride transport, visual perception, circadian rhythm regulation, and several ubiquitination/ufmylation and signaling processes, with only a couple of terms sharing modest counts. There isn\u2019t a clear, single biological function or pathway uniting these terms, and the lack of edges suggests the proteins may not form a cohesive functional cluster. Therefore, a specific label isn\u2019t justifiable.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030321","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0042752","count":2},{"id":"GO:1902065","count":1},{"id":"GO:0032434","count":1}]},{"hash":"1360069129283065991","title":"Diverse solute transmembrane transporters","description":"The top GO terms point to transport across membranes for a wide range of substrates (nitrate/nitrite, galactose, sodium, vitamins, xenobiotics, phosphate) and even neurotransmitter loading into synaptic vesicles, indicating a cluster of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":19,"edges":40,"triangles":41,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0035725","count":3}]},{"hash":"1617531555769774049","title":"Retroviral Integration and Proviral Latency","description":"The top GO terms strongly point to retroviral life cycle processes: viral entry into the host nucleus, integration into the host genome, proviral latency, and RNA-templated DNA synthesis (reverse transcription). Supporting terms about DNA replication/recombination and host-pathogen interactions further align with retroviral infection and genome integration.","confidence":"High","size":19,"edges":169,"triangles":935,"max_degree":18,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0006310","count":9},{"id":"GO:0015074","count":8},{"id":"GO:0075732","count":8},{"id":"GO:0075713","count":8}]},{"hash":"1812046172707741913","title":"Viral DNA integration and proviral latency","description":"This cluster is defined by GO terms related to DNA replication and integration, RNA-templated DNA biosynthesis, DNA recombination, and explicit steps of the retroviral life cycle such as viral penetration into the host nucleus and establishment of integrated proviral latency. The presence of negative regulation of siRNA processing suggests viral counter-defense mechanisms, reinforcing a viral infection/retroviral integration theme. Collectively, the terms point to proteins involved in viral genome integration and latency maintenance.","confidence":"High","size":19,"edges":86,"triangles":227,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":11},{"id":"GO:0015074","count":10},{"id":"GO:0075732","count":10},{"id":"GO:0075713","count":10},{"id":"GO:0006310","count":10}]},{"hash":"1762484360216699602","title":"Cytoskeleton Dynamics and Vesicle Trafficking","description":"The top GO terms cluster around actin- and microtubule-dependent processes (filopodium and ruffle assembly, microtubule-based movement, and mitotic spindle assembly) and vesicle/organellar trafficking (endosome to lysosome transport, Cvt pathway). While a few terms are broader or organism-specific, the dominant theme is cytoskeletal remodeling coupled with intracellular transport, suggesting a group of proteins coordinating shape changes with vesicle trafficking.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:0043524","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0097178","count":3}]},{"hash":"236344143445438714","title":"Developmental transcriptional regulation and signaling","description":"The cluster centers on transcriptional control (DNA-templated transcription, regulation of transcription by RNA polymerase II) and cell cycle regulation, with enrichment for intracellular signaling. Several terms point to tissue development and differentiation (mammary gland alveolus development, Leydig cell differentiation, negative regulation of oocyte maturation), while others reflect environmental signal sensing (blue light signaling, hypoxia detection). Together, these terms suggest proteins that coordinate transcriptional programs with signaling pathways during development and differentiation.","confidence":"Medium","size":19,"edges":47,"triangles":22,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032026","count":8},{"id":"GO:0000122","count":7},{"id":"GO:0071157","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0060749","count":7}]},{"hash":"490579142997688336","title":"Unknown","description":"The GO terms are highly diverse, spanning immune signaling (Fc receptor inhibitory signaling), transcriptional regulation, various morphogenesis processes (tricuspid valve and bronchus), metabolism (glycogen catabolism, glucose signaling), prostaglandin response, yeast growth, and cell cycle control. There isn\u2019t a single cohesive biological theme that ties these terms together across the protein set, so a definite, interpretable label is not warranted.","confidence":"","size":19,"edges":126,"triangles":413,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002774","count":19},{"id":"GO:0000435","count":19},{"id":"GO:0003186","count":19},{"id":"GO:0032298","count":19},{"id":"GO:0045819","count":19}]},{"hash":"1253510165658057481","title":"Cytoskeletal dynamics and cell motility","description":"Dominant GO terms include centrosome separation and microtubule polymerization, along with locomotion in locomotory behavior, suggesting a theme of cytoskeletal rearrangements enabling cell movement. Additional terms reference metabolism and inflammatory response, which may be secondary associations or annotation noise, but the core signal aligns with microtubule- and centrosome-related motility.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051299","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0031987","count":2},{"id":"GO:0044258","count":1},{"id":"GO:0030157","count":1}]},{"hash":"419073333558299951","title":"Unknown","description":"The top GO terms are diverse, covering immune cell migration, neural migration, general cellular movement, and various glycosylation pathways, with no clear single function linking all proteins. There are no edges or cohesive connections among the terms in this cluster, so a specific, representative label cannot be assigned. ","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002522","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0010493","count":1},{"id":"GO:0042355","count":1},{"id":"GO:0021799","count":1}]},{"hash":"560000736631874262","title":"Unknown","description":"The listed GO terms cover immune signaling (chemokine production, inflammatory response), nervous system development, apoptosis, metabolism, and even mitotic processes, with no clear, unified biological function tying the proteins together. Some terms are obsolete, suggesting annotation noise. Therefore, no single coherent label fits this cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0006032","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0005975","count":1}]},{"hash":"1027094385885930162","title":"ECM remodeling and protease regulation","description":"The top GO terms point to extracellular matrix disassembly and regulation of proteolysis, with supporting signals from cell-cell adhesion and protease activity control. While a few terms like hypoxia and Sertoli development are more divergent, the core theme appears to be ECM remodeling and protease regulation shaping cell interactions.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0045861","count":1},{"id":"GO:0008209","count":1},{"id":"GO:0032933","count":1}]},{"hash":"538187846477997028","title":"Embryonic Development and Organogenesis","description":"This cluster includes GO terms for odontogenesis, forelimb morphogenesis, cerebral cortex regionalization, Sertoli cell and male gonad development, germ cell proliferation, neuroblast proliferation, sex determination, and somitogenesis\u2014together pointing to broad embryonic organ formation and developmental patterning rather than a single pathway.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042487","count":2},{"id":"GO:0035115","count":2},{"id":"GO:0021796","count":1},{"id":"GO:0060009","count":1},{"id":"GO:0007290","count":1}]},{"hash":"1646623693679399997","title":"Transmembrane Ion and Metabolite Transport","description":"The proteins cluster around diverse transmembrane transport activities: sodium and potassium ion transport, various nutrient and xenobiotic transports (galactose, vitamins, nitrate/nitrite, fucose-related metabolism), and even a synaptic vesicle neurotransmitter loading term. The common thread is membrane transport and substrate translocation across membranes, justifying a focused label on transmembrane transport of ions and metabolites.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0015757","count":3}]},{"hash":"725746546589176749","title":"Glycosaminoglycan proteoglycan biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for chondroitin sulfate, heparan sulfate, and dermatan sulfate proteoglycans, i.e., glycosaminoglycan proteoglycan synthesis and metabolism. The presence of chondrocyte development and ureteric bud formation supports roles in extracellular matrix proteoglycan function during development. While some terms are obsolete or less related, the core theme is production and metabolism of sulfated GAG chains on proteoglycans, pointing to an ECM/development-related cluster.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":8},{"id":"GO:0015015","count":8},{"id":"GO:0030208","count":7},{"id":"GO:0015014","count":7},{"id":"GO:0002063","count":7}]},{"hash":"1666788564236443595","title":"Telomere maintenance and spindle assembly","description":"This cluster is dominated by GO terms tied to telomere organization and maintenance (telomeric localization, capping, telomere length regulation) along with spindle assembly during mitosis, and includes poly-ADP-ribosylation activities that often intersect DNA repair and telomere biology. The Wnt term appears as a secondary context but the core theme is telomere regulation coupled with mitotic chromosome management.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":3},{"id":"GO:0070212","count":3},{"id":"GO:0032212","count":3},{"id":"GO:1904908","count":3},{"id":"GO:1904743","count":3}]},{"hash":"2085973703064181747","title":"Glycosaminoglycan biosynthesis and cartilage development","description":"Most terms point to glycosaminoglycan/proteoglycan biosynthesis (heparan sulfate, dermatan/chondroitin sulfate) and chondrocyte development, suggesting an ECM/Cartilage-related function. Some terms are obsolete or unrelated (maltose transport, neuronal stem cell maintenance), but the dominant signal supports GAG synthesis and cartilage formation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010899","count":3},{"id":"GO:0097150","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0010493","count":3},{"id":"GO:0030208","count":2}]},{"hash":"1100133174977654700","title":"Unknown","description":"The top terms across the cluster cover a wide range of unrelated processes (angiogenesis, cardiac conduction, cell cycle, hormone secretion, neural differentiation, immune signaling, apoptosis, PARP activity, pain perception, and cytokine regulation). No single, cohesive function ties these proteins together, so a precise, intuitive label isn\u2019table to be determined from the given terms alone.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":2},{"id":"GO:0086070","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0030103","count":2},{"id":"GO:0021707","count":2}]},{"hash":"166590469142593897","title":"TLR-Mediated Inflammatory Signaling","description":"The top GO terms cluster around innate immune signaling and inflammation, including MyD88-dependent TLR signaling, I\u03baB phosphorylation (NF-\u03baB pathway), macrophage activation, and inflammatory response. This suggests a coherent theme of TLR-driven immune activation, with some noise from a few unrelated terms, but overall the cluster reflects innate immune inflammatory signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0007252","count":2},{"id":"GO:0070171","count":2},{"id":"GO:0051770","count":2},{"id":"GO:0002322","count":2}]},{"hash":"934550122720108926","title":"Neuronal development and synaptic receptor regulation","description":"Top GO terms point to neuronal development and synaptic function (cerebellar granule cell differentiation; anterior/posterior lateral line development; sensory perception of touch) alongside processes of receptor trafficking (receptor internalization and clustering) and signaling modulation (ERK cascade). The presence of protein ubiquitination further supports post-translational regulation of neuronal receptors and signaling at synapses. Together, these terms suggest a cluster centered on neuronal development with emphasis on synaptic receptor dynamics and signaling regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0021707","count":2},{"id":"GO:0050975","count":2},{"id":"GO:0031623","count":2},{"id":"GO:0043113","count":2}]},{"hash":"734609189790454468","title":"RNA Pol II transcription initiation and histone modification","description":"The cluster shows a coherent theme of transcriptional regulation linked to chromatin state, highlighted by GO terms for DNA-templated transcription initiation, RNA polymerase II preinitiation complex assembly, and various histone acetylation/phosphorylation events, including regulation of transcription of Notch targets.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006352","count":1},{"id":"GO:0051090","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0007221","count":1}]},{"hash":"1377421537293726789","title":"Viral genome integration and proviral latency","description":"The top GO terms cluster around DNA integration, viral entry into the host nucleus, and establishment of integrated proviral latency, with supporting signals for DNA-templated transcription and DNA replication. The presence of symbiont entry and host apoptosis activation terms further supports a virus/host interaction theme centered on genome integration and manipulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1359644909928101463","title":"Adaptive Immune Activation and Germinal Center Formation","description":"The top GO terms cluster around B cell receptor signaling, germinal center formation, memory T cell differentiation, and type 2 immune response, indicating coordinated adaptive immune activation and lymphoid differentiation (germinal center processes). Some terms appear unrelated (phototropism, renal sodium absorption) and likely noise, but the strongest signals point to adaptive immunity and germinal center biology.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":6},{"id":"GO:0042787","count":6},{"id":"GO:2001200","count":5},{"id":"GO:0043380","count":4},{"id":"GO:0009638","count":4}]},{"hash":"925787269530151872","title":"Innate Immune Signaling & Cytokine Production","description":"The cluster is enriched for innate immune terms (innate immune response; type II interferon production; interleukin-2 production), suggesting an immune signaling theme. A few development-related terms appear (neural crest migration, cuticle development), which may reflect multifunctional proteins or annotation noise, but the dominant signal points to innate immunity and cytokine signaling. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0010765","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0008363","count":1},{"id":"GO:1905404","count":1}]},{"hash":"1421574442704536017","title":"Ubiquitin-Related Proteostasis and Histone Modification","description":"The top terms cluster around ubiquitin signaling and processing (deubiquitination, ubiquitin recycling, regulation of ubiquitin ligases) and histone modification (histone deubiquitination, histone methylation). There are also links to proteostasis (aggresome assembly) and cellular stress responses (ischemia), suggesting a shared theme of ubiquitin- and chromatin-centered regulation under stress. While some terms are peripheral, the strongest connection is ubiquitin-dependent regulation and chromatin modification.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002931","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0044313","count":1},{"id":"GO:0035616","count":1},{"id":"GO:0010992","count":1}]},{"hash":"1760190051620370555","title":"Symbiont-driven immune modulation and barrier biosynthesis","description":"The GO terms cluster around immune modulation by symbionts (symbiont-mediated suppression of host adaptive immune response; regulation of tolerance induction; negative regulation of MHC II biosynthesis; antigen processing via MHC II) and host barrier formation processes (suberin and cutin biosynthesis). This suggests a theme of host defense modulation coupled with epidermal barrier biosynthesis, justifying a combined label that reflects both aspects.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001759","count":2},{"id":"GO:0002643","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0002495","count":1},{"id":"GO:0010345","count":1}]},{"hash":"1818859279061702964","title":"Cardiovascular Ion Transport and Development","description":"The cluster\u2019s top GO terms are dominated by ion transmembrane transport (sodium and potassium), pointing to ion channel\u2013related functions. Several terms also reflect cardiovascular development and function (atrioventricular canal development, blood circulation, blood vessel remodeling, innervation), suggesting a core theme of heart and vascular biology. A few terms related to immune signaling and transcription regulation (T cell differentiation, miRNA transcription, host-mediated viral transcription) appear less central but indicate broader regulatory roles among cluster members. Overall, the dominant motif is ion transport linked to cardiovascular development, with additional regulatory processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0036302","count":1},{"id":"GO:0007628","count":1},{"id":"GO:0008015","count":1}]},{"hash":"198629368036231887","title":"Embryogenesis and Organogenesis","description":"These proteins appear to participate broadly in developmental gene regulation and tissue differentiation. The prevalent GO terms describe embryonic development, placental/trophoblast differentiation, EMT-related morphogenesis, and organ-specific lineage development (endocrine pancreas, pituitary, cartilage, left-right patterning), suggesting a coherent embryogenesis/organogenesis program.","confidence":"High","size":18,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0035270","count":6}]},{"hash":"505558310217968544","title":"RNA processing and ribosome biogenesis","description":"This cluster is dominated by GO terms related to RNA metabolism and protein synthesis, including translation, ribosome biogenesis, and mRNA splicing (and its regulation), suggesting a cohesive function in RNA processing and the assembly of translation machinery. Some outlier terms exist, but the core signal points to RNA processing/translation biology.","confidence":"Medium","size":18,"edges":75,"triangles":115,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:1901407","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0048026","count":4}]},{"hash":"1723659235907888885","title":"Glycerophospholipid remodeling and immune signaling","description":"The top terms cluster around lipid biosynthesis and remodeling\u2014CDP-diacylglycerol biosynthesis, ether lipid biosynthesis, phosphatidylcholine and cardiolipin remodeling, and platelet activating factor biosynthesis\u2014imply a lipid metabolism focus. Immune-related terms (IL-2 production and negative regulation of activation-induced T cell death) suggest an immunomodulatory aspect linked to lipid signaling. Some neural/development terms appear but do not dominate, so the core theme remains lipid remodeling with possible immune involvement.","confidence":"Medium","size":18,"edges":66,"triangles":126,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0016024","count":6},{"id":"GO:0070236","count":6},{"id":"GO:0070970","count":6},{"id":"GO:0021587","count":6},{"id":"GO:0008611","count":6}]},{"hash":"845359812462387444","title":"Membrane Biogenesis and Transport","description":"The cluster is dominated by GO terms related to membrane organization and function, including protein insertion into membranes, outer membrane assembly in Gram-negative bacteria, and cristae formation, suggesting a focus on membrane biogenesis and complex transport processes. Additional terms like monoatomic anion transport and redox/oxidative stress responses fit with membrane-associated integrity and function, while the presence of some neuronal terms appears to be annotation noise in this context. Overall, a membrane-centric label best captures the shared biology of this group.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060992","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0051205","count":2},{"id":"GO:0043165","count":2}]},{"hash":"1584818076568594571","title":"Unknown","description":"The top GO terms span ubiquitin-dependent protein degradation, muscle development, various immune cell differentiation events, and even plant tropism, indicating no single coherent function tying the cluster together. Therefore a distinct, representative label cannot be inferred.","confidence":"","size":18,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0048741","count":4},{"id":"GO:1900477","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0043380","count":3}]},{"hash":"1795525014198740058","title":"Unknown","description":"The top GO terms include aging, angiogenesis, cardiac cell communication, vasopressin secretion, neural differentiation, apoptosis, protein ADP-ribosylation, and pain perception, reflecting diverse processes without a single cohesive function. Therefore I cannot assign a confident, representative label for this cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":3},{"id":"GO:0043547","count":3},{"id":"GO:1903589","count":3},{"id":"GO:0086070","count":3},{"id":"GO:0030103","count":3}]},{"hash":"407052540978117260","title":"Metabolic and Growth Signaling","description":"The proteins in this cluster show enrichment for core metabolic processes (thiamine biosynthesis, tetrahydrofolate metabolism, glycerol catabolic process) and growth-related signals (positive regulation of stem cell proliferation, megakaryocyte differentiation), plus a cellular response to cAMP. This combination suggests a theme around metabolism linked to cell growth and signaling, though several terms are obsolete and the set is somewhat heterogeneous.","confidence":"Medium","size":18,"edges":95,"triangles":299,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0045654","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0046653","count":4},{"id":"GO:0060992","count":4}]},{"hash":"1057146103302312316","title":"Viral entry and proviral integration","description":"This cluster centers on processes of viral or symbiont entry into host cells, DNA integration and proviral latency, and related genome mobility (transposition) as well as cytoskeletal remodeling (ruffle assembly) and cell polarity changes. These terms together point to proteins involved in virus/parasite-host interactions and genome integration events, rather than standard housekeeping roles. Confidence: Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0039651","count":4}]},{"hash":"26263823344009853","title":"Nematode cuticle formation and molting","description":"The dominant signal is larval chitin-based cuticle development with related molting cycle terms, pointing to genes involved in nematode cuticle biosynthesis and molt regulation; additional terms touch on nematode embryogenesis and reproduction but do not overshadow the core cuticle/molt theme.","confidence":"High","size":18,"edges":26,"triangles":11,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":14},{"id":"GO:0006508","count":2},{"id":"GO:0018996","count":1},{"id":"GO:0048632","count":1},{"id":"GO:0007313","count":1}]},{"hash":"1415544271118139087","title":"Larval cuticle development","description":"The top GO term is \"larval chitin-based cuticle development,\" suggesting involvement in larval cuticle formation, likely chitin biosynthesis or assembly. The cluster's high edge and triangle counts support a coordinated structural or biosynthetic role in cuticle production.","confidence":"High","size":18,"edges":88,"triangles":195,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":16}]},{"hash":"1073325525416632942","title":"Unknown","description":"The top GO terms include immune cell differentiation (dendritic cells, pro-T cells, memory T cells, germinal center formation) but also plant-specific processes (phototropism, gravitropism) and general regulatory processes (cell cycle regulation, ubiquitination). This mix suggests no single coherent function tying the proteins together, implying annotation noise rather than a distinct functional module.","confidence":"","size":18,"edges":22,"triangles":12,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":4},{"id":"GO:2001200","count":4},{"id":"GO:0043380","count":4},{"id":"GO:0032764","count":4},{"id":"GO:2000176","count":4}]},{"hash":"1485143563238103260","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by GO:0008363, indicating involvement in larval chitin-based cuticle development. The single, specific term suggests a cohesive functional theme around exoskeletal formation during larval stages, likely comprising structural cuticle proteins and enzymes related to chitin deposition. ","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":18}]},{"hash":"1328746872945934491","title":"Chitin metabolism and insect cuticle development","description":"The cluster is dominated by chitin catabolic process and larval chitin-based cuticle development terms, pointing to genes involved in chitin turnover and cuticle formation in insects. Additional terms related to carbohydrate metabolism and immune mediator production appear, suggesting some metabolic and immune signaling roles, but the main theme is chitin metabolism and cuticle biosynthesis.","confidence":"High","size":18,"edges":42,"triangles":56,"max_degree":14,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":14},{"id":"GO:0002532","count":14},{"id":"GO:0090197","count":14},{"id":"GO:0005975","count":14},{"id":"GO:0008363","count":2}]},{"hash":"558138376721255159","title":"Neural Development Signaling Network","description":"The top GO terms cluster around nervous system development and signaling cascades (nervous system development; smoothened signaling; Roundabout pathway; ERK/MAPK and PI3K signaling; Rho regulation), suggesting proteins linked by developmental signaling activities shaping neural tissues. Although kidney development and ossification appear, the dominant theme is neural-development signaling networks rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":13},{"id":"GO:0046777","count":12},{"id":"GO:0070374","count":11},{"id":"GO:0001822","count":11},{"id":"GO:0043552","count":11}]},{"hash":"1871439600409292944","title":"Larval mechanosensory and neural development","description":"This cluster centers on developmental processes related to larval sensory systems and neural signaling, highlighted by terms like larval chitin-based cuticle development, lateral line development (a mechanosensory system in fish), cellular response to mechanical stimulus, and regulation of synaptic transmission/plasticity. Immune-related terms (inflammatory response, NF-kappaB signaling, response to lithium) appear but are less central, suggesting the main theme is the growth and modulation of sensory-neural pathways in larvae with some ancillary immune signaling context.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0001967","count":2},{"id":"GO:0010226","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0042346","count":2}]},{"hash":"1224352128518847979","title":"Ribosome Biogenesis and Translation Machinery","description":"The top GO terms cluster around core protein synthesis and ribosome assembly\u2014translation, initiation/termination, elongation, and ribosomal large subunit biogenesis. These collectively point to a cohesive module of ribosome production and translation machinery; a single glial proliferation term may reflect context-specific annotation rather than core function. Overall, the dominant theme is ribosome biogenesis coupled with translation.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0006415","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0000027","count":4}]},{"hash":"319883530818189967","title":"Sugar Transporters and Carbohydrate Metabolism","description":"This cluster is strongly enriched for transport-related GO terms involving importing various sugars (fructose, glucose, xylose, trehalose) across the plasma membrane, along with related carbohydrate metabolism and responses to glucose availability/starvation. The repeated emphasis on sugar transport across membranes (and a connected ascorbate metabolism term) suggests a cohesive group of sugar transporter proteins and associated carbohydrate-processing functions. Some terms (quorum sensing, replicative senescence) appear peripheral or annotation-driven rather than core to the cluster. Overall, the dominant theme is carbohydrate transport and metabolism.","confidence":"High","size":18,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:1990539","count":17},{"id":"GO:0044381","count":17},{"id":"GO:0019852","count":17},{"id":"GO:0015753","count":17},{"id":"GO:0052106","count":17}]},{"hash":"1223611756924509880","title":"Rho GTPase signaling in neural development and synapses","description":"This cluster centers on regulation and activation of Rho GTPase signaling, with multiple terms for Rho pathway activity, dendrite development, synapse organization, cochlea morphogenesis, and vocalization behavior. The convergence on neural differentiation and synaptic formation, driven by Rho GTPases, best explains the cluster's protein set, with ancillary associations to polarity and centrosome localization.","confidence":"High","size":18,"edges":59,"triangles":99,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":9},{"id":"GO:0050808","count":9},{"id":"GO:0071625","count":9},{"id":"GO:0007266","count":8},{"id":"GO:0090103","count":8}]},{"hash":"2091379357235111015","title":"Neural development and brain patterning","description":"The top GO terms point to central nervous system development, brain region specification (e.g., superior colliculus development, dorsal identity regulation), and development-related transcription/chromatin remodeling, suggesting a cluster of proteins involved in neural development and brain patterning. Some terms (root development, vacuole junction assembly) appear less directly related, indicating a mix of signals but with a dominant neural-development theme.","confidence":"Medium","size":18,"edges":87,"triangles":209,"max_degree":17,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0048364","count":7},{"id":"GO:0072699","count":5},{"id":"GO:0030997","count":5},{"id":"GO:0061380","count":5},{"id":"GO:0071562","count":5}]},{"hash":"1898503755223779763","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0016310","count":2},{"id":"GO:0000738","count":2},{"id":"GO:0002107","count":2},{"id":"GO:0010606","count":2}]},{"hash":"1962572309432994212","title":"Immune signaling and RNA silencing regulation","description":"These proteins show enrichment for innate/adaptive immune regulation (positive regulation of RIG-I signaling; B cell homeostasis; negative regulation of T-helper cell differentiation) and RNA silencing/miRNA metabolism, with additional hints of cellular stress responses (aggresome assembly; plasma membrane repair) and nitric oxide regulation. The common theme appears to be immune signaling modulated by RNA-based regulatory processes, rather than a single cohesive pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900246","count":3},{"id":"GO:2000637","count":3},{"id":"GO:0050680","count":2},{"id":"GO:0045019","count":2},{"id":"GO:0070842","count":2}]},{"hash":"854394762164362142","title":"Cell signaling and tissue morphogenesis","description":"The cluster is dominated by GO terms for intracellular signal transduction, cell movement, and morphogenetic processes across multiple tissues (adipocyte differentiation, placental branching morphogenesis, endothelial sprouting, cardiac cell communication), with supporting terms about kinase activity regulation and cell cycle. This pattern points to a broad signaling- and differentiation-centric group rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0035556","count":4},{"id":"GO:0045444","count":4},{"id":"GO:0071901","count":4}]},{"hash":"1448497801119050862","title":"Lectin-Pathway Complement and Fc Receptor Signaling","description":"This cluster centers on innate immune activation: lectin- pathway complement activation, C-type lectin receptor signaling, Fc-gamma receptor signaling, and phagocytosis-related processes, complemented by basophil activation and NK cell chemotaxis regulation. While a couple of terms hint at tissue remodeling (lymph vessel morphogenesis, cartilage condensation), the dominant signals reflect antibody- and lectin-mediated immune recognition and inflammatory signaling.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":17},{"id":"GO:0036303","count":15},{"id":"GO:0090403","count":15},{"id":"GO:0002223","count":15},{"id":"GO:0006910","count":15}]},{"hash":"1776158676004202343","title":"Unknown","description":"The listed GO terms are highly heterogeneous, covering developmental signaling (positive regulation of smoothened signaling), proteolysis, RNA hydrolysis, sulfur metabolism, flavonoid metabolism, and various developmental processes (germ-band extension, myelination, angiogenesis, fertilization). These processes span different organisms and tissues, with no clear shared pathway or function unifying the cluster. The absence of edges/triangles among proteins further suggests no tight functional module. Therefore no coherent label could be assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045880","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0090503","count":3},{"id":"GO:0000103","count":3},{"id":"GO:0009812","count":3}]},{"hash":"219327663560113497","title":"Neural development and synaptic regulation","description":"This cluster shows enrichment for neuronal development terms (cerebellar granule cell differentiation, lateral line development) and signaling pathways (Wnt), along with synaptic transmission and plasticity regulation, suggesting proteins involved in neural development and modulation of synaptic function. The ER protein folding term may reflect general secretory pathway roles in neurons, but the core signal aligns with neural development and synaptic regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":3},{"id":"GO:0021707","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0050806","count":1}]},{"hash":"1431871688459114779","title":"Neural signaling and sensory development","description":"The terms cluster around neural signaling and sensory processing, including GABA and dopamine pathways, synaptic plasticity (long-term potentiation), locomotion and learned behavior (locomotory behavior, conditioned taste aversion), innervation and inner ear receptor development, and ion transport, all pointing to neuronal/sensory system function and plasticity.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":10},{"id":"GO:0001661","count":10},{"id":"GO:0007214","count":10},{"id":"GO:0060119","count":9},{"id":"GO:0060384","count":9}]},{"hash":"1401593192964791427","title":"Nucleic Acid Repair and tRNA Modification","description":"This cluster centers on nucleic acid maintenance: tRNA wobble uridine modification, RNA/DNA repair, and mRNA processing, plus regulatory links to stress-induced mitochondrial necrosis. The convergence of tRNA modification with base repair indicates a shared role in preserving translation and genome integrity under cellular stress, with a possible connection to programmed necrotic pathways.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035553","count":1},{"id":"GO:0002098","count":1},{"id":"GO:0042245","count":1},{"id":"GO:1902445","count":1},{"id":"GO:0012501","count":1}]},{"hash":"1836053082277110244","title":"Immune and Hematopoietic Signaling","description":"The top GO terms are dominated by immune receptor pathways (KIT, Fc-epsilon receptor, IL-6 signaling) and related hematopoietic development (megakaryocyte development), with additional developmental and trafficking terms. This supports a cohesive theme around immune signaling linked to blood cell development, despite some broader developmental terms.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038109","count":2},{"id":"GO:0038095","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0048070","count":2}]},{"hash":"1998198954244568276","title":"Ion transporters and vesicle loading","description":"The cluster\u2019s top GO terms are dominated by ion transmembrane transport (sodium, potassium, nitrite, xenobiotic) and related membrane transport activities, with neurotransmitter loading into synaptic vesicles highlighting vesicle-associated processes. Receptor clustering and ossification-related terms are present but less prominent, suggesting the core function centers on membrane transport and vesicle handling rather than bone biology. This supports labeling as membrane transport and vesicle loading.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0006855","count":1},{"id":"GO:0071248","count":1}]},{"hash":"964584406369559158","title":"Extrinsic apoptotic signaling and Rac/GTPase regulation","description":"The top GO terms center on extrinsic apoptotic signaling via death domain receptors, with concurrent regulation of Rac and GTPase activity, suggesting a cluster of proteins involved in death-receptor\u2013mediated apoptosis and small GTPase signaling. Negative regulation of Rac and endocytic recycling points to cytoskeletal and trafficking control linked to apoptosis, while incidental terms about development may reflect broader signaling roles in various tissues.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035021","count":2},{"id":"GO:0045671","count":2},{"id":"GO:2001136","count":2},{"id":"GO:0008625","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1112985581708325459","title":"ECM Proteoglycan Synthesis and Angiogenesis","description":"Top GO terms indicate proteoglycan (heparan sulfate and chondroitin sulfate) biosynthesis and extracellular matrix components, alongside vascular-related processes such as angiogenesis, coagulation, and fibrinolysis, plus inflammatory responses. This suggests a coherent theme of ECM remodeling coupled with vascular/inflammatory regulation, justifying a label focused on proteoglycan synthesis and angiogenesis.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0006953","count":3}]},{"hash":"735815875022909149","title":"Ubiquitin-Dependent Proteolysis in Embryonic Development","description":"This cluster is driven by GO terms for ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process and autoubiquitination), indicating a core theme around protein turnover via the ubiquitin-proteasome system. The inclusion of multiple development-related terms (endocrine system development, placental/embryonic differentiation, left-right pattern formation, EMT in heart formation, cartilage morphogenesis, pancreatic cell development) suggests these ubiquitin-regulated proteins participate in diverse developmental processes. The combination points to a functional grouping of ubiquitin-regulated proteolysis with developmental regulation rather than a single tissue-specific role.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0051865","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3}]},{"hash":"834091042095359062","title":"Neural development and glutamatergic synapses","description":"The GO terms cluster around nervous system development and synaptic function: neural tube closure, cerebellar granule cell differentiation, learning (olfactory and visual), and glutamatergic synaptic transmission with receptor clustering and excitatory postsynaptic potentials. Additional terms like taurine transport hint at neuronal membrane activities, reinforcing a coherent theme of brain development and excitatory synaptic signaling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0015734","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0001403","count":3},{"id":"GO:0021707","count":3}]},{"hash":"1557650553261830179","title":"Embryonic development and morphogenesis","description":"This label fits because the top GO terms cluster around embryonic development and tissue morphogenesis\u2014placental/trophoblast differentiation, left-right patterning, EMT in heart cushion formation, cartilage morphogenesis, and endocrine organ development (pancreas). The lone mRNA splicing term is a minor outlier, but the dominant theme is developmental morphogenesis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0060972","count":1}]},{"hash":"884459815226060175","title":"Unknown","description":"The top GO terms indicate a mix of developmental and signaling processes across different organisms (e.g., muscle development, leaf morphogenesis, NF-\u03baB signaling, membrane repair, and regulation of viral entry) and include obsolete annotations, with no clear unifying function for the 18 proteins; this makes a confident, specific label unlikely.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010873","count":2},{"id":"GO:0071313","count":2},{"id":"GO:0055002","count":2},{"id":"GO:0060776","count":2},{"id":"GO:0030433","count":2}]},{"hash":"1792371223910589467","title":"Neuronal vesicle trafficking and synaptic signaling","description":"The top terms collectively emphasize neural development and synaptic regulation, including ER-Golgi vesicle transport, endocytic recycling and early endosome localization, acetylcholine receptor clustering at synapses, regulation of synaptic plasticity, and Wnt signaling in neural contexts. A few terms are peripheral, but the dominant theme points to neuronal vesicle trafficking and synaptic signaling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902953","count":2},{"id":"GO:1904395","count":2},{"id":"GO:0021517","count":2},{"id":"GO:0030299","count":2},{"id":"GO:2001137","count":2}]},{"hash":"812336414898953448","title":"Membrane Sugar and Ion Transport","description":"The Top Terms are dominated by transmembrane transport processes for ions (sodium, potassium) and sugars (fructose, glucose, xylose, trehalose), pointing to proteins that function as or participate in membrane transport. A few terms touch on metabolism or stress responses (e.g., L-ascorbic acid metabolism, glucose starvation, replicative senescence), but the unifying theme is transport across the plasma membrane for sugars and ions. Therefore, this label best captures the cluster\u2019s primary shared function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:1990539","count":2},{"id":"GO:0044381","count":2},{"id":"GO:0019852","count":2}]},{"hash":"805786809555157852","title":"T cell regulation and cytokine signaling","description":"This cluster\u2019s top GO terms center on immune modulation, especially T cell activity and cytokine production (positive regulation of IL-2 and IL-10, CD8+ T cell apoptotic regulation, and regulation of activated T cell proliferation), along with macrophage activation and phagocytosis. There are a few ancillary terms (cell adhesion, symbiont entry, lens morphogenesis) that are less central, but the dominant theme is immune signaling and T cell regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905404","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0043031","count":3}]},{"hash":"1673220834714712335","title":"Xenobiotic Detoxification and Aromatic Degradation","description":"The GO terms cluster around detoxification and catabolic processing of diverse xenobiotics and aromatic compounds (beta-ketoadipate pathway, stilbene and alkaloid catabolism, uracil catabolic, 1,2-dichloroethane catabolic) and cellular oxidant detoxification, suggesting a shared function in breaking down/toxifying substances. The presence of an odd-term like regulation of endocannabinoid signaling may reflect broader regulatory links rather than a single metabolic module, so the overall theme centers on xenobiotic handling and aromatic compound degradation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":2},{"id":"GO:0009820","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0019260","count":2},{"id":"GO:0097755","count":2}]},{"hash":"88617192464732210","title":"Neural development and synaptic regulation","description":"This cluster includes GO terms tied to neural and sensory development (cerebellar granule cell differentiation, otolith and lateral line system development) and to modulation of synaptic activity (positive/negative regulation of synaptic transmission, short-term plasticity). The presence of hair follicle development and pattern formation hints at broader developmental programs, but the unifying theme appears to be forming neural/sensory structures and tuning their synaptic function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0001942","count":2},{"id":"GO:0048840","count":2},{"id":"GO:0060972","count":2}]},{"hash":"2009137932632993814","title":"Tissue development with inflammation and ECM remodeling","description":"The top GO terms point to biomineral and mineralized tissue development (amelogenesis, biomineral tissue development, elastin catabolic process) alongside immune/inflammatory processes (leukocyte migration, response to lipopolysaccharide, blood coagulation). Transcription regulation terms and additional developmental processes appear as well, but the core theme combines tissue development with extracellular matrix remodeling and inflammatory responses. This label captures the cluster's apparent focus, with medium confidence given the term diversity.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":8},{"id":"GO:0045944","count":8},{"id":"GO:0097186","count":7},{"id":"GO:0002523","count":7}]},{"hash":"1871951308053452501","title":"Stress Response and Inflammation Regulation","description":"The terms cluster around stress and immune signaling (response to toxic substances, negative regulation of acute inflammatory response, glucocorticoid response, oxidative signaling) and include metabolic and developmental contexts (insulin signaling, nitrogen utilization, cell-matrix adhesion, CNS/pulmonary differentiation). While some terms like CNS development and olfactory perception are more divergent and could reflect pleiotropy, the core theme appears to be how cells sense and modulate stress and inflammatory cues across tissues. Confidence: Medium.","confidence":"","size":17,"edges":30,"triangles":31,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":7},{"id":"GO:0008286","count":6},{"id":"GO:0009636","count":6},{"id":"GO:0002674","count":6},{"id":"GO:0071460","count":6}]},{"hash":"1591386386100219992","title":"Telomere maintenance and telomeric localization factors","description":"This cluster shows a strong concentration of telomere-related GO terms: positive regulation of telomere maintenance via telomerase, protein localization to the telomeric region, telomere capping, and related telomere-binding processes, suggesting a core telomere biology theme. Spindle assembly and actin bundle assembly appear as secondary associations, but the central signal is telomere maintenance and telomeric localization.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":6},{"id":"GO:0051225","count":6},{"id":"GO:0070212","count":5},{"id":"GO:1904743","count":5},{"id":"GO:1904908","count":5}]},{"hash":"1090163824600242401","title":"Gram-positive cell wall biosynthesis and division","description":"The top GO terms cluster around lipoteichoic acid biosynthesis, peptidoglycan biosynthesis, cell wall organization, and cell division/regulation of cell shape, pointing to a cohesive theme of bacterial cell envelope biosynthesis and cytokinesis. Some unrelated terms (digestive tract development, anthocyanin biosynthesis) may reflect annotation noise, but the strongest signals support a Gram-positive cell wall and division function.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":3},{"id":"GO:0048565","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0009718","count":2}]},{"hash":"875591203920920306","title":"DNA recombination and developmental transcription","description":"The top GO terms center on DNA recombination and DNA integration, with transcription by RNA polymerase II and several development-related terms (gonad, pancreas, muscle differentiation, motor neuron fate). This suggests a cluster of proteins involved in genome remodeling and transcriptional regulation during development, potentially coordinating gene expression while maintaining genome integrity. The presence of ion-response and anti-apoptotic terms hints at accompanying signaling and cell-survival roles in developmental contexts. Overall, the cluster seems cohesive around genome remodeling coupled with transcriptional control in development.","confidence":"Medium","size":17,"edges":36,"triangles":38,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0071277","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0071276","count":4}]},{"hash":"2285968481757975889","title":"TGF-\u03b2\u2013Responsive Development and Differentiation","description":"The cluster centers on developmental processes and differentiation across tissues, with strong signals for TGF-\u03b2\u2013related responses and multicellular development, including lens and cerebellar neuron differentiation and gonad development. This suggests a core theme of TGF-\u03b2\u2013driven developmental signaling, complemented by regulatory processes like epithelial polarity, receptor internalization, ubiquitination, and GPCR pathway involvement that coordinate tissue formation.","confidence":"High","size":17,"edges":15,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0021707","count":2}]},{"hash":"309422295757537630","title":"Embryonic Development and Tissue Differentiation","description":"This cluster is dominated by GO terms referencing developmental processes across multiple tissues (placenta/trophoblast differentiation, EMT in heart development, endocrine system development, cartilage and pancreatic cell development, left-right patterning). The common theme is broad embryogenesis and organ differentiation, rather than a single pathway. Confidence: High","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060806","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0060536","count":7}]},{"hash":"1343511486871841297","title":"Centrosome Localization and Spindle Assembly","description":"Based on GO terms such as maintenance of centrosome location, gamma-tubulin complex localization to mitotic spindle pole body, and mitotic spindle assembly, this cluster appears enriched for proteins involved in centrosome function and spindle organization during cell division. A few unrelated terms (endocytic recycling, pinocytosis, cytokine production, tight junction localization) appear, but the dominant theme is centrosome/spindle assembly.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051661","count":1},{"id":"GO:0010735","count":1},{"id":"GO:1903478","count":1},{"id":"GO:0014809","count":1},{"id":"GO:1990735","count":1}]},{"hash":"991614529399605505","title":"Nuclear mRNA export and transcription regulation","description":"The proteins cluster around nuclear RNA processing and transport, with strong signals for mRNA export from the nucleus and transcriptional regulation by RNA polymerase II, plus related nuclear import/export and splicing factor activity. Some links to centrosome/kinetochore regulation suggest cell-cycle coordination, but the core theme is nuclear RNA processing/export and gene expression control.","confidence":"High","size":17,"edges":131,"triangles":609,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006406","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0034501","count":4},{"id":"GO:0000055","count":3},{"id":"GO:0006609","count":3}]},{"hash":"1805689432849380135","title":"Ubiquitin-Dependent Protein Degradation and Immune Regulation","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic process and autoubiquitination, indicating a core role in protein turnover and ubiquitin signaling. It also includes immune differentiation and regulation terms (dendritic cell and pro-/memory T cell differentiation, cytokine regulation), suggesting the ubiquitin system modulates immune development and activation. Some stress and cell cycle-related terms are present but likely secondary to ubiquitin-mediated regulation. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0051865","count":3},{"id":"GO:1903378","count":3},{"id":"GO:0000083","count":3},{"id":"GO:0071276","count":3}]},{"hash":"210820494383668409","title":"Unknown","description":"The top GO terms span diverse, unrelated processes (redox, antibiotic and polymer biosynthesis, menaquinone biosynthesis) with several obsolete entries, alongside vertebrate-specific terms like lung development and presynaptic membrane assembly. There are no edges or shared functional themes linking the proteins, so a coherent cluster label cannot be inferred from the terms provided.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0017000","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0098869","count":3},{"id":"GO:0030324","count":3}]},{"hash":"809016650336349407","title":"Unknown","description":"The top GO terms include several neural development and synaptic terms (regulation of neuronal synaptic plasticity, synapse maturation, commissural neuron axon guidance, neural crest migration, vestibulocochlear nerve organization) but also digestion, glycogen catabolism, amelogenesis, and leukocyte migration, indicating a highly heterogeneous set with no single cohesive function. With no edges or shared functional theme, a specific, representative label cannot be confidently assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048168","count":2},{"id":"GO:0007586","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0005980","count":2},{"id":"GO:0060074","count":1}]},{"hash":"641733643549548198","title":"Antibiotic biosynthesis and central carbon metabolism","description":"The terms point to a cohesive bacterial theme centered on producing antibiotics alongside core energy and metabolite pathways: antibiotic biosynthesis, quinone biosynthesis (phylloquinone and menaquinone), glycolysis, TCA cycle, fatty acid beta-oxidation, and amino acid catabolism (valine). This suggests a cluster of proteins involved in secondary metabolite production tied to primary metabolism.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":12},{"id":"GO:0010124","count":8},{"id":"GO:0009234","count":8},{"id":"GO:0006574","count":8},{"id":"GO:0006635","count":8}]},{"hash":"389776305273297433","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by the GO term for larval chitin-based cuticle development (16 hits), strongly suggesting involvement in insect exoskeleton formation and chitin metabolism. The remaining terms are sparse and represent disparate processes, but do not redefine the main theme. ","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":16},{"id":"GO:0043524","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0031384","count":1}]},{"hash":"1868732058320666482","title":"Unknown","description":"The GO terms span apoptosis, xenobiotic and antibiotic responses, ectodermal differentiation and amelogenesis, cytoskeletal dynamics, neuronal spine maintenance, angiogenesis, and symbiont entry into host cells, with no clear single theme linking all functions. Therefore, a concise, representative label is not evident.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097192","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0097186","count":2},{"id":"GO:0010668","count":2}]},{"hash":"973908965766151752","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by the GO term for larval chitin-based cuticle development (9 hits), indicating a cohesive theme around larval cuticle formation. The remaining annotations are few and largely obsolete or unrelated, suggesting the core function is cuticle development rather than other processes.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":9},{"id":"GO:0071479","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0006414","count":1},{"id":"GO:0032232","count":1}]},{"hash":"2186163043201186030","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0071560","count":2}]},{"hash":"13884716904672576","title":"Embryonic Development and Tissue Morphogenesis","description":"The terms cluster around developmental processes and morphogenesis across multiple tissues (placenta/trophoblast, heart, cartilage, pancreas), with differentiation and pattern formation concepts; ubiquitin-related terms indicate regulation of protein turnover during development rather than a single pathway.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0043066","count":4},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3}]},{"hash":"2279865202882476743","title":"Unknown","description":"Top Terms are not provided for this cluster, so I cannot infer a common function or process linking the proteins. The cluster appears highly interconnected (127 edges, 581 triangles, max degree 16), which suggests a protein\u2013protein interaction module, but without GO terms to anchor a function, an accurate label cannot be assigned.","confidence":"","size":17,"edges":127,"triangles":581,"max_degree":16,"top_function":null,"top_go_terms":[]},{"hash":"1760907303541836519","title":"RNA Processing and Nuclear Export Regulation","description":"This cluster\u2019s terms are dominated by regulation of RNA metabolism and nucleocytoplasmic transport: regulation of mRNA export from the nucleus, regulation of ribosomal large subunit export from the nucleus, and regulation of tRNA processing. The presence of ubiquitin-dependent protein catabolic process via the multivesicular body pathway aligns with coordinated regulation of RNA processing and ribosome biogenesis, while a few terms appear incidental. Overall, the data point to a theme of RNA processing and nuclear export regulation.","confidence":"Medium","size":17,"edges":22,"triangles":6,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0019089","count":1},{"id":"GO:0060360","count":1},{"id":"GO:0043162","count":1},{"id":"GO:0030579","count":1}]},{"hash":"1166715980204074117","title":"Cardiac and Neural Development Signaling","description":"The top GO terms point to heart development and neural tissue development (hippocampus and cerebellar cortex development), combined with signaling pathways (Rho, integrin, TNF production, PI3K-related activity) that regulate proliferation and cellular signaling. This suggests a theme of developmental signaling coordinating heart and brain development, rather than a single, narrow function.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0060045","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0042535","count":2},{"id":"GO:0007266","count":2}]},{"hash":"2246225849419404050","title":"Sodium and Potassium Ion Transporters","description":"The top GO terms are sodium ion transmembrane transport and potassium ion transmembrane transport (4 each), indicating the cluster is enriched for membrane transport proteins that mediate Na+/K+ flux. Other terms present (response to ethanol, IgA isotype switching, and various developmental morphogenesis terms) are much less represented and may reflect secondary roles or annotation noise, but the dominant signal is ion transport across membranes.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0045471","count":3},{"id":"GO:0048298","count":2},{"id":"GO:0001501","count":2}]},{"hash":"1910151638779189376","title":"Unknown","description":"The GO terms are highly diverse: cholesterol transport, axis development, integrin activation, immunoglobulin production, and RNA biogenesis processes. With only sparse edges and no clear shared function, there isn\u2019t a cohesive theme to label; thus Unknown with None confidence.","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032367","count":1},{"id":"GO:2001274","count":1},{"id":"GO:0007311","count":1},{"id":"GO:0002642","count":1},{"id":"GO:0030917","count":1}]},{"hash":"894771328892073314","title":"Neural development and myelination","description":"Several top terms converge on nervous system development (CNS and PNS) and myelination, as well as axon-related localization and neural cell adhesion, suggesting roles in neural connectivity and myelin formation. While terms like BMP signaling and heart development are present, they appear less central to the cluster\u2019s core theme.","confidence":"High","size":17,"edges":63,"triangles":128,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030513","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0061000","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0034164","count":4}]},{"hash":"984648368936652079","title":"Adrenergic GPCR Signaling and Cardiovascular Regulation","description":"The cluster is dominated by GO terms tied to adrenergic GPCR signaling (adenylate cyclase activation, cAMP pathways) and cardiovascular effects (vasoconstriction, blood pressure regulation), with supportive metabolic themes such as diet-induced thermogenesis and energy metabolism (electron transport chain). Pain perception and temperature response terms likely reflect broader sympathetic and nociceptive signaling contexts. Overall, the proteins appear to function in coordinating sympathetic signaling with cardiovascular and metabolic responses.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0045777","count":10},{"id":"GO:0007190","count":9},{"id":"GO:0002024","count":9}]},{"hash":"1164615667515196317","title":"Unknown","description":"The Top Terms span diverse processes\u2014from angiogenesis and cardiac conduction to neural differentiation, hepatocyte apoptosis, and immune signaling\u2014with no single, cohesive biological theme tying the terms together. The lack of edges or recurrent pathway signals further suggests the proteins do not cluster around a common function, so the label Unknown with None confidence is appropriate.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":4},{"id":"GO:0086070","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0030103","count":4},{"id":"GO:0021707","count":4}]},{"hash":"1628904966130586578","title":"Developmental transcription and tissue development","description":"The cluster is dominated by GO terms for DNA-templated transcription and broad multicellular development, with specific links to neural tube closure, skin development, and skeletal system development, pointing to embryonic development and tissue formation. Additional terms for ER-stress\u2013related apoptosis and metal/immune responses suggest accompanying cellular stress and defense signaling often seen during development. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1200016474401729493","title":"Mitochondrial heme biosynthesis and redox processes","description":"This cluster centers on mitochondrial-related metabolism and redox biology: protoporphyrinogen IX biosynthesis (heme synthesis), protein import into the mitochondrial intermembrane space, intracellular iron ion homeostasis, oxidative stress response, and deglutathionylation. These terms suggest a common theme of mitochondrial function and redox regulation, with a few terms that seem less related likely reflecting broader or orphan annotations. Overall, the strongest linkage is mitochondrial heme biosynthesis and redox processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":1},{"id":"GO:0042628","count":1},{"id":"GO:0007620","count":1},{"id":"GO:0034599","count":1},{"id":"GO:0045041","count":1}]},{"hash":"934925493398458311","title":"Unknown","description":"The top GO terms include DNA replication and its regulation, but also a wide mix of seemingly unrelated processes (focal adhesion regulation, Fc signaling, galactose-induced transcription, heart valve morphogenesis, pseudohyphal growth, prostaglandin response, glucose regulation). This broad and incongruent set of functions provides no single, cohesive theme to represent the cluster, so a concise, meaningful label cannot be assigned.","confidence":"","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":16},{"id":"GO:0051893","count":16},{"id":"GO:0002774","count":15},{"id":"GO:0000435","count":15},{"id":"GO:0003186","count":15}]},{"hash":"1078283561780418742","title":"Angiogenesis and vascular regulation","description":"This cluster\u2019s top terms are dominated by angiogenesis and its positive regulation, plus related vascular processes like coagulation and fibrinolysis, indicating a focus on blood vessel formation and maintenance. The presence of innervation and norepinephrine regulation hints at neurovascular signaling, suggesting a broader vascular-regulatory role including inflammatory/hemostatic aspects. Overall, the proteins appear tied to vascular development and homeostasis with neuroendocrine modulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0060384","count":2},{"id":"GO:0014061","count":2},{"id":"GO:0014068","count":2}]},{"hash":"665715618555780807","title":"Proteoglycan Biosynthesis and Glycosaminoglycan Metabolism","description":"Top GO terms point to proteoglycan biosynthesis (heparan and keratan sulfate) and related carbohydrate metabolism (N-acetylglucosamine), suggesting a core role in glycosaminoglycan assembly and extracellular matrix modification. The inclusion of sulfation-related processes and an embryonic craniofacial morphogenesis term reinforces an ECM/developmental context. Some terms describe broader xenobiotic/hormone metabolism, but the strongest signal is proteoglycan/GAG biosynthesis, justifying this label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006711","count":1},{"id":"GO:0006068","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0006044","count":1},{"id":"GO:0006478","count":1}]},{"hash":"2099842908983965016","title":"Small GTPase signaling in immune responses","description":"The cluster is driven by GO terms involving activation and regulation of small GTPases (Rho, Ras), plus related GTPase-mediated signaling. It also includes immune-related terms (B cell maturation, IL-4 and IL-7 responses) and GPCR/insulin signaling components, suggesting a cohesive theme where small GTPase\u2013driven signaling coordinates immune signaling alongside growth-factor pathways.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":2},{"id":"GO:0048009","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0002344","count":2},{"id":"GO:0046580","count":2}]},{"hash":"1047737141272648043","title":"Neural development and synapse assembly with membrane transport","description":"The cluster is enriched for nervous system development and synapse assembly terms (GO:0007399, GO:0051965) and includes cell adhesion notes, pointing to roles in neural connectivity. The accompanying membrane transport terms (amino acid and calcium export, sialic acid transport) suggest these proteins also function at the plasma membrane to support signaling and cell interactions, consistent with neural development and synapse formation; bone ossification and Rac/TNF regulation appear as ancillary processes within broader development. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032973","count":3},{"id":"GO:1990034","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0007157","count":2}]},{"hash":"1103904116435188805","title":"Epithelial polarity and tight junction assembly","description":"Cluster shows strong representation of epithelial polarity (GO:0090162) and bicellular tight junction assembly (GO:0070830), along with small GTPase\u2013mediated signaling (GO:0007264) and Golgi to plasma membrane transport (GO:0043001). The mix of insulin signaling, brown fat differentiation, and apoptotic processes suggests broader developmental and metabolic roles, but the core theme points to epithelial cell architecture and associated trafficking/signaling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0008286","count":2}]},{"hash":"2299468706682537691","title":"Light-Regulated Transcription and Circadian Signaling","description":"The strongest shared theme among the terms is transcriptional regulation linked to light signaling and circadian rhythm (DNA-templated transcription, regulation of transcription, far-red/light phototransduction, and regulation of circadian rhythm). Other terms like face morphogenesis or fructose response are less consistent with this theme, so the core cluster appears to reflect light-driven transcriptional control and circadian signaling, with some outliers.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002038","count":1},{"id":"GO:0060325","count":1},{"id":"GO:0009750","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0045892","count":1}]},{"hash":"1672575433166547584","title":"GTPase Signaling and Transcription Regulation","description":"This cluster centers on small GTPase\u2013related signaling (positive regulation of GTPase activity, Rac regulation, GPCR signaling, TORC1 pathway) with concurrent transcription- and mRNA-related processes (DNA-templated transcription, mRNA transport) and post-translational control (ubiquitination), suggesting a broader theme of signaling control feeding into gene expression.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0070262","count":2},{"id":"GO:0038202","count":2},{"id":"GO:0051028","count":2}]},{"hash":"60848357926869254","title":"Immune cell differentiation and germinal center formation","description":"The top GO terms cluster around immune system development and differentiation, including dendritic cell differentiation, pro-T cell differentiation, memory T cell differentiation, and germinal center formation, suggesting a cohesive theme of immune cell maturation and adaptive immune structure formation. A few terms (phototropism, gravitropism, a ubiquitination process) seem unrelated or noisy, so while the theme is present, the connection isn\u2019t perfectly tight. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":1},{"id":"GO:2001200","count":1},{"id":"GO:0043380","count":1},{"id":"GO:0032764","count":1},{"id":"GO:2000176","count":1}]},{"hash":"989385296871105941","title":"Amino acid, lipid, and cofactor metabolism","description":"This cluster is dominated by metabolism/biosynthesis terms for amino acids (aspartate, alanine), cofactors (biotin, heme), and lipids (sphinganine), with fatty acid homeostasis also represented. Notch signaling appears as an outlier, but the shared theme is metabolite and cofactor biosynthesis.","confidence":"Medium","size":16,"edges":23,"triangles":5,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006533","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0042853","count":1},{"id":"GO:0034276","count":1},{"id":"GO:0019441","count":1}]},{"hash":"2212452780143587888","title":"Embryonic Development and Organogenesis","description":"These proteins are annotated with multiple embryonic development and morphogenesis terms, including placenta-related differentiation, epithelial-to-mesenchymal transition in heart development, cartilage morphogenesis, pancreatic endocrine cell development, endocrine system development, left-right pattern formation, and midbrain development. A few entries refer to transcriptional regulation, but the dominant theme is embryogenesis and organ morphogenesis, suggesting the cluster represents developmentally related proteins rather than a single pathway. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060806","count":6}]},{"hash":"1476364488571341991","title":"Multilineage Development and Transcription Regulation","description":"This cluster is enriched for terms across embryonic and tissue-specific differentiation (in utero embryonic development, endocrine pancreas, skeletal muscle, neuron, megakaryocyte), along with transcriptional control (DNA-templated transcription and its regulation) and hormone biosynthesis, plus an inflammatory response. The combination suggests proteins involved in coordinating developmental differentiation programs and transcriptional regulation across multiple lineages, rather than a single pathway.","confidence":"Medium","size":16,"edges":27,"triangles":11,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043046","count":5},{"id":"GO:0045654","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0031018","count":4},{"id":"GO:0035914","count":4}]},{"hash":"1443658033432876608","title":"Chromatin organization and transcription regulation","description":"Most terms cluster around nuclear processes: nucleus organization, chromatin assembly (including rDNA and pericentric heterochromatin), transcription preinitiation complex assembly, RNA polymerase II transcription regulation, and chromatin remodeling activities. These together point to a chromatin organization and transcription control module. A few terms (innate immune response in mucosa, midbrain morphogenesis, and dosage compensation) are less directly connected and may reflect broad, pleiotropic roles of some proteins in the set.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002227","count":1},{"id":"GO:0006997","count":1},{"id":"GO:0007549","count":1},{"id":"GO:0070481","count":1},{"id":"GO:0045898","count":1}]},{"hash":"2043599485390328302","title":"Embryogenesis and Organogenesis","description":"Top GO terms cluster around development and morphogenesis across multiple tissues (placenta, endocardial cushion EMT, cartilage, pancreas, midbrain) and overall embryogenesis, with transcriptional regulation as a supporting theme. The proteins do not form a connected interaction network, suggesting a broad developmental theme rather than a single pathway. Therefore, a concise label like Embryogenesis and Organogenesis aptly captures the cluster.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":4},{"id":"GO:0060806","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1511672505701631434","title":"Bacterial Biosynthetic Pathways","description":"This cluster\u2019s top GO terms are dominated by diverse biosynthetic processes (lipoteichoic acid, lysine via diaminopimelate, L-proline, ectoine, menaquinone, antibiotic biosynthesis, phenylpropanoid metabolism, bile acid metabolism), along with some catabolic processes. The common thread is the involvement in production of various metabolites and cell-wall components typical of bacterial metabolism, with some secondary metabolism signals. Therefore, a concise label reflecting bacterial biosynthetic activities is appropriate.","confidence":"Medium","size":16,"edges":83,"triangles":262,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":6},{"id":"GO:0009450","count":4},{"id":"GO:0009089","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0055129","count":4}]},{"hash":"1859289404017336586","title":"Unknown","description":"The GO terms span diverse functions from protein quality control (ubiquitin-dependent ERAD) and actin regulation to angiogenesis, cardiac signaling, hormone secretion, neural differentiation, apoptosis, nociception, and ADP-ribosylation. There is no single coherent theme linking these processes, so a specific, representative cluster label cannot be assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0034316","count":3},{"id":"GO:1903589","count":2},{"id":"GO:0086070","count":2},{"id":"GO:0007049","count":2}]},{"hash":"1881852860321636267","title":"GPCR signaling and receptor internalization","description":"The dominant GO terms center on G protein-coupled receptor signaling and internalization, including GPCR-mediated adenylate cyclase activation and GTPase regulation, with supporting hints from receptor oligomerization and downstream processes like blood pressure regulation and thermogenesis. This pattern suggests a cohesive GPCR-focused cluster rather than an unrelated mix of functions.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002031","count":4},{"id":"GO:0051262","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1693510664116724148","title":"Developmental Gene Regulation and Signaling","description":"The cluster shows strong enrichment for developmental processes (multicellular organism development, heart/tricuspid valve morphogenesis) and transcriptional regulation (DNA-templated transcription, RNA Pol II\u2013promoter activity). While there are also terms for calcium signaling, apoptosis, DNA repair, and immune signaling, the core theme appears to be regulation of gene expression in developmental contexts.","confidence":"Medium","size":16,"edges":82,"triangles":228,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":11},{"id":"GO:0006281","count":10},{"id":"GO:0050850","count":10},{"id":"GO:0007275","count":10},{"id":"GO:0006351","count":10}]},{"hash":"247078485317563488","title":"Core metabolism and translation","description":"The proteins are linked to translation (protein synthesis) and multiple central metabolic processes (glycolysis, TCA cycle, amino acid biosynthesis/catabolism, and fatty acid/malonyl-CoA pathways). This mixture points to a broad, housekeeping metabolic/translational module rather than a single specific pathway, with the pituitary gland development term likely an incidental tissue annotation rather than a core function.","confidence":"Medium","size":16,"edges":53,"triangles":80,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006099","count":3},{"id":"GO:0042759","count":3},{"id":"GO:2001295","count":3},{"id":"GO:0019483","count":2}]},{"hash":"1338203586178684826","title":"Glutamatergic synapse signaling and plasticity","description":"The top GO terms center on neuronal communication at glutamatergic synapses, including synaptic transmission and excitatory postsynaptic potentials, plus receptor clustering, which together imply roles in excitatory synaptic signaling and plasticity. Visual learning terms further support a memory-related aspect, while other terms like transcription and ubiquitination may reflect broader neuronal gene regulation. Overall, the cluster seems best characterized by glutamatergic synaptic signaling and plasticity.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0006915","count":2}]},{"hash":"609660046433306590","title":"Arthropod cuticle development and morphogenesis","description":"Top GO terms point to chitin-based cuticle development and body morphogenesis, suggesting the proteins cluster around arthropod cuticle formation and body patterning during development. This provides a coherent theme: structural development of the exoskeleton and body plan. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":9},{"id":"GO:0010171","count":9}]},{"hash":"1944533300816957357","title":"Larval chitin-based cuticle development","description":"The strongest signal is larval chitin-based cuticle development (GO:0008363) with 10 proteins, suggesting a primary role in larval cuticle formation. The other terms indicate additional signaling and immune-related or membrane-trafficking processes (e.g., calcium signaling, TNF/T cell terms, palmitoylation) that may reflect multifunctional proteins or annotation noise, but they do not outweigh the dominant developmental function.","confidence":"Medium","size":16,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":10},{"id":"GO:0032760","count":1},{"id":"GO:0050848","count":1},{"id":"GO:0042102","count":1},{"id":"GO:0010742","count":1}]},{"hash":"505448428899360167","title":"Actin Cytoskeleton Remodeling and Rho Signaling","description":"The top terms cluster around actin filament organization, crosslinking, cortical patch assembly, and membrane remodeling, with regulation of Rho protein signaling (plus related phosphorylation and synaptic plasticity contexts). This points to actin cytoskeleton dynamics modulated by Rho pathways as the unifying theme.","confidence":"Medium","size":16,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097320","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0007015","count":2},{"id":"GO:0051764","count":2}]},{"hash":"2240500040194372505","title":"Neuronal signaling and plasticity","description":"This cluster is dominated by GO terms tied to neural activity and synaptic function, such as excitatory postsynaptic potential, regulation of long-term neuronal synaptic plasticity, and sensory perception of touch, with the canonical Wnt signaling pathway also supporting neural development and synapse formation. While a few terms relate to general development or mitosis, the neural-related terms are the strongest signal, suggesting the cluster centers on neuronal signaling and plasticity. ","confidence":"Medium","size":16,"edges":15,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:1902953","count":2},{"id":"GO:0060070","count":2},{"id":"GO:0050975","count":2},{"id":"GO:0048169","count":2}]},{"hash":"663888812056052779","title":"RNA Pol II Transcription Core Machinery","description":"GO terms in this cluster center on RNA polymerase II\u2013mediated transcription, covering initiation, promoter clearance, elongation, and snRNA transcription, suggesting these proteins collectively form or support the core transcription machinery for gene expression.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001111","count":2},{"id":"GO:0001174","count":2},{"id":"GO:0006368","count":2},{"id":"GO:0006367","count":2},{"id":"GO:0080163","count":2}]},{"hash":"1409580088941003203","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster's terms center on ubiquitination (polyubiquitination, autoubiquitination, K48-linked ubiquitination), ubiquitin-dependent protein catabolic processes, and ER-associated degradation, pointing to a core function in tagging proteins for degradation and regulating proteostasis; other terms like transcriptional or translation-related processes appear secondary. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0070936","count":2},{"id":"GO:0042787","count":2}]},{"hash":"729226665277320541","title":"Innate immune activation and phagocytosis","description":"These terms cluster around innate immune signaling and effector functions in myeloid cells: stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, and phagocytosis recognition indicate phagocytic/antigen-presenting activity; basophil activation and NK cell chemotaxis regulation point to broader innate immune modulation; positive regulation of platelet activation can reflect immune-platelet crosstalk. Lymph vessel morphogenesis and some developmental terms are less central and may reflect tissue context, but the core theme is innate immune signaling and phagocytic activity.","confidence":"Medium","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":10},{"id":"GO:0090403","count":10},{"id":"GO:0002223","count":10},{"id":"GO:0006910","count":10},{"id":"GO:0038094","count":10}]},{"hash":"742544309387533816","title":"Membrane Transporters","description":"This cluster shows enrichment for transmembrane transport of ions and small molecules (e.g., Na+, K+, fructose, glucose, nitrite, xylose, ascorbate) and related transporter processes like neurotransmitter loading into vesicles, pointing to a cohesive set of membrane transporter proteins with diverse substrates.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0006855","count":2},{"id":"GO:1990539","count":2},{"id":"GO:0015707","count":2}]},{"hash":"924587185189106230","title":"Unknown","description":"The GO terms cover a wide range of developmental processes across tissues (kidney branching, tooth dentin odontogenesis, ovarian and male gonad development, lymphoid differentiation, and neural/synaptic functions) with no obvious unifying theme; there are no edges indicating shared protein function, so a cohesive label cannot be confidently assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071312","count":2},{"id":"GO:0001658","count":2},{"id":"GO:0042475","count":2},{"id":"GO:0001541","count":2},{"id":"GO:0032091","count":2}]},{"hash":"2118171746692997887","title":"Growth Factor Signaling Modulators","description":"The GO terms cluster around regulation and mediation of various signaling pathways, notably growth factor receptor signaling (IGF, growth hormone), canonical Wnt signaling, small GTPase signaling (Rac), and related regulatory processes. Several terms denote negative regulation of signaling and differentiation, suggesting these proteins act as modulators across multiple signaling cascades rather than a single pathway. The mix of growth factor, developmental, and immune-related signaling terms supports a theme of broad signal regulation rather than a specific process. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048745","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0035021","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0045671","count":2}]},{"hash":"2204790624202891870","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":16,"triangles":7,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030154","count":1},{"id":"GO:0008283","count":1},{"id":"GO:0045892","count":1},{"id":"GO:0071076","count":1},{"id":"GO:0070102","count":1}]},{"hash":"170527576112960263","title":"Immune signaling and endocytic regulation","description":"The terms point to a module that modulates immune signaling (dsRNA response, TNF production, neutrophil degranulation) while also affecting cellular trafficking and receptor dynamics (endomytic recycling, endosome-to-membrane transport) and small GTPase\u2013mediated signaling (Rac/Rho). This suggests a cohesive theme of regulating immune responses in conjunction with receptor trafficking, rather than a single straightforward pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071360","count":2},{"id":"GO:0035021","count":1},{"id":"GO:0032760","count":1},{"id":"GO:0060396","count":1},{"id":"GO:0045671","count":1}]},{"hash":"2147325144239468854","title":"Unknown","description":"The top GO terms are highly diverse, spanning nicotine response, hearing, amino acid response, acrosome reaction, aging, glial apoptosis, B cell proliferation regulation, cell fate commitment, apoptotic DNA fragmentation, and heart development. This broad mix across nervous, reproductive, immune, and cardiac contexts provides no single cohesive function to anchor a meaningful label, so a generic Unknown is most appropriate.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035094","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0007340","count":2},{"id":"GO:0001302","count":2}]},{"hash":"836103484534954733","title":"Immune receptor signaling and phagocytosis","description":"The top GO terms cluster around innate immune signaling and phagocytic processes: Fc-gamma receptor signaling, C-type lectin receptor signaling, phagocytosis recognition, basophil activation, and regulation of NK cell chemotaxis. While a couple of terms relate to development (lymph vessel morphogenesis, cartilage condensation, metanephric limb development), the dominant theme is immune cell activation and receptor-mediated pathogen recognition leading to phagocytosis and inflammatory responses.","confidence":"Medium","size":16,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":8},{"id":"GO:0090403","count":8},{"id":"GO:0002223","count":8},{"id":"GO:0006910","count":8},{"id":"GO:0038094","count":8}]},{"hash":"1524038147861795972","title":"Regulators of signaling and development","description":"The top GO terms cluster around modulation of signaling pathways (positive regulation of ERK1/ERK2 cascade, positive regulation of GTPase activity, and regulation of Rho signaling) and cytosolic calcium release, with additional developmental contexts (heart development, primary ovarian follicle growth, spermatid development) and responses ( xenobiotic stimulus, IL-2 production). This suggests the proteins act as regulators that tune signaling cascades and developmental programs rather than executing a single pathway, despite the lack of direct interactions in the edge data.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0051209","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0001545","count":3}]},{"hash":"2077395422079569794","title":"Organogenesis and Cytoskeletal Dynamics","description":"This cluster includes several developmental processes (thymus development, odontogenesis, angiogenesis) alongside cytoskeletal-related activities (actin filament organization, spindle microtubule\u2013kinetochore attachment). The common thread appears to be organogenesis and cytoskeletal regulation, with a few mitotic-spindle related terms. Therefore, Organogenesis and Cytoskeletal Dynamics is a concise, representative label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034394","count":3},{"id":"GO:0090268","count":2},{"id":"GO:0048538","count":2},{"id":"GO:0051315","count":2},{"id":"GO:2001240","count":2}]},{"hash":"603704664058462426","title":"Retina Development and GPCR-CAMP Signaling","description":"Dominant terms center on retina development and GPCR-activated cAMP signaling, with accompanying proliferation-related terms and GTPase regulation, suggesting a theme of GPCR-cAMP\u2013mediated signaling influencing retinal development and cell growth. Metabolic terms like electron transport and blood pressure regulation appear less central to the core theme. ","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060041","count":13},{"id":"GO:0008284","count":13},{"id":"GO:0043547","count":13},{"id":"GO:0008283","count":13},{"id":"GO:0010579","count":12}]},{"hash":"481612821360625719","title":"Retroviral Entry, Integration, and Proviral Latency","description":"The GO terms cluster around retroviral life-cycle steps and host interactions: entry into the host cell and nucleus, DNA integration into the host genome, and establishment of proviral latency, along with reverse-transcription\u2013like RNA-templated DNA synthesis and DNA replication/recombination activities. Additional terms about symbiont-mediated effects and host antiviral responses (e.g., siRNA processing) support a viral\u2013host interaction theme. This convergence strongly supports labeling the cluster with retroviral entry, integration, and latency as the core function represented.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0006260","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4}]},{"hash":"305099254636543125","title":"Fc and C-type lectin signaling with phagocytosis","description":"Top GO terms indicate immune receptor signaling (Fc-gamma receptor, C-type lectin receptor) and phagocytosis, with supporting signals for NK cell regulation, basophil activation, and platelet activation, pointing to a theme of immune activation and antibody/pattern-recognition\u2013driven responses. Some developmental terms appear, but the core cluster aligns with innate immune signaling and phagocytic processes.","confidence":"Medium","size":16,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":6},{"id":"GO:0090403","count":6},{"id":"GO:0002223","count":6},{"id":"GO:0006910","count":6},{"id":"GO:0038094","count":6}]},{"hash":"788378422825904039","title":"Skeletal and Neural Differentiation","description":"This cluster is enriched for development and differentiation terms across bone and neural lineages, including endochondral ossification, osteoblast and chondrocyte differentiation, neuroblast development, Schwann cell differentiation, and myelination. The strongest signals point to lineage specification in skeletal and nervous systems, with some additional terms related to epidermal regulation and transcriptional control, suggesting a broader but cohesive theme of differentiation programs during development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":3},{"id":"GO:0002250","count":2},{"id":"GO:0002051","count":2},{"id":"GO:0002062","count":2},{"id":"GO:0045669","count":2}]},{"hash":"1155558290987380266","title":"Sugar and small-molecule transmembrane transport","description":"The cluster is enriched for GO terms describing transmembrane transport of diverse small molecules (fructose, glucose, D-xylose, arabinose, nitrite, xenobiotics) and vesicular transport of neurotransmitters, indicating a cohesive membrane transport function rather than a single substrate-specific activity.","confidence":"High","size":16,"edges":57,"triangles":51,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":16},{"id":"GO:1990539","count":16},{"id":"GO:0015707","count":16},{"id":"GO:0098700","count":16},{"id":"GO:0042891","count":16}]},{"hash":"891792840300271729","title":"Organogenesis and tissue differentiation","description":"The cluster centers on developmental processes and tissue differentiation, with terms like multicellular organism development, axonogenesis, lens fiber cell differentiation, prostate glandular development, and oocyte fate determination. Also includes DNA-templated transcription and proliferation, suggesting an active developmental transcriptional program. A few outliers (defense response and ubiquitin-related regulation) are present but do not outweigh the overall developmental theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1447261162133661194","title":"Proteoglycan and glycosaminoglycan biosynthesis","description":"This cluster is dominated by proteoglycan biosynthetic terms (heparan sulfate and keratan sulfate) and related glycosaminoglycan metabolism (N-acetylglucosamine). The embryonic neurocranium morphogenesis term supports ECM/glycosaminoglycan roles in development, indicating a proteoglycan/ECM\u2013related function as the main theme, despite some ancillary xenobiotic/hormone metabolism terms.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006711","count":1},{"id":"GO:0006068","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0006044","count":1},{"id":"GO:0006478","count":1}]},{"hash":"126060090388047899","title":"Innate immune inflammatory signaling","description":"Top GO terms center on inflammatory response, MyD88-dependent TLR signaling, NF-\u03baB regulation, macrophage activation, and B cell proliferation, indicating these proteins function together in innate immune response and inflammation. The presence of JAK-STAT pathway regulation and protein ubiquitination further supports a signaling module rather than metabolic functions.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0007252","count":2},{"id":"GO:0070171","count":2},{"id":"GO:0051770","count":2},{"id":"GO:0002322","count":2}]},{"hash":"514002134076565350","title":"Unknown","description":"The top terms span diverse processes\u2014from insect cuticle development and organ morphogenesis to neuronal signaling, GPCR pathways, cAMP biosynthesis, transport, and autophagy\u2014showing no single cohesive function that binds the cluster. Without a clear common theme, a specific intuitive label cannot be confidently assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0050826","count":1},{"id":"GO:0030242","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0032792","count":1}]},{"hash":"2012833749205760636","title":"Neurodevelopment and organogenesis","description":"Proteins in this cluster are annotated with multiple developmental processes, particularly neural development (axon extension, neuron projection development, spinal cord development) and other organogenesis (lens fiber differentiation, skeletal system development). The inclusion of mRNA splicing and Rho signaling suggests broader cellular differentiation and cytoskeletal regulation accompanying development. Taken together, the cluster represents developmental programs with a strong emphasis on neurodevelopment.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0048675","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0007275","count":2}]},{"hash":"958657801495825801","title":"Neural development and signaling","description":"The terms cluster around neural growth and signaling (neuron maturation, nerve branching morphogenesis, dopamine response) with supporting links to cytoskeletal regulation (Rho signaling) and protein regulation (autoubiquitination). A few immune/angiogenesis terms appear but the core theme ties to neurite development and neuronal signaling networks.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902499","count":2},{"id":"GO:0002755","count":2},{"id":"GO:0014041","count":2},{"id":"GO:0035023","count":2},{"id":"GO:1903351","count":2}]},{"hash":"406623460156592569","title":"Skeletal muscle differentiation and chromatin regulation","description":"The top GO terms strongly center on skeletal muscle differentiation and sarcomere organization, pointing to a muscle-development theme. Additional terms related to heart development and epigenetic regulation (histone modifications and transcription elongation) suggest this cluster represents muscle development influenced by chromatin-level control.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":3},{"id":"GO:0045214","count":2},{"id":"GO:0044648","count":2},{"id":"GO:0003290","count":2},{"id":"GO:1903709","count":2}]},{"hash":"1118415889668064883","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034473","count":2},{"id":"GO:0032066","count":2},{"id":"GO:0071048","count":2},{"id":"GO:0071049","count":2},{"id":"GO:0040009","count":2}]},{"hash":"1906726526389585611","title":"Developmental Morphogenesis and Signaling","description":"These terms cluster around developmental processes and tissue morphogenesis across several lineages (neural, muscular, glandular, bone) and include guidance, branching, and signaling (axon guidance, BMP signaling, neural crest migration, myoblast fusion, bone mineralization). While there is diversity (immune activation/apoptosis terms), the common theme is involvement in developmental patterning and morphogenesis rather than a single cell type. Therefore the label Developmental Morphogenesis and Signaling captures the overarching theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":2},{"id":"GO:0060445","count":2},{"id":"GO:0007520","count":2},{"id":"GO:0042113","count":1},{"id":"GO:0030500","count":1}]},{"hash":"94711341156660857","title":"Vertebrate embryonic organogenesis and morphogenesis","description":"The proteins are linked to a broad set of embryonic development processes across multiple organs (heart, gonads, placenta, eye, hindlimb, outflow tract), with terms for morphogenesis and organ development, plus regulatory signals like estrogen signaling and apoptosis/myoblast proliferation. This points to a coherent theme of vertebrate embryonic organogenesis and tissue morphogenesis.","confidence":"High","size":15,"edges":48,"triangles":46,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":11},{"id":"GO:0007507","count":10},{"id":"GO:0035116","count":10},{"id":"GO:0060527","count":10},{"id":"GO:0030520","count":10}]},{"hash":"42804829176314031","title":"Organogenesis across heart, nerves, muscle, retina","description":"This cluster shows strong representation of developmental processes across multiple tissues: heart development, peripheral nervous system development, myoblast fusion (muscle formation), retina morphogenesis, and nerve signaling, with Rho signaling linking cytoskeletal changes to these differentiation events. The terms suggest a broad developmental/organogenesis theme rather than a single, cohesive molecular function.","confidence":"Medium","size":15,"edges":83,"triangles":254,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":12},{"id":"GO:0007520","count":10},{"id":"GO:0051092","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0048378","count":9}]},{"hash":"604126896150908305","title":"Embryonic organ morphogenesis","description":"The top GO terms point to development and morphogenesis across multiple organs (heart, midbrain, cochlea, pancreas, nephric duct) rather than a single tissue, with one broader term on transcriptional regulation. This suggests the proteins collectively participate in developmental regulation during organ formation, rather than a specific pathway or tissue. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0030901","count":5},{"id":"GO:0090103","count":5},{"id":"GO:0008585","count":5},{"id":"GO:0061113","count":4}]},{"hash":"947803255918807122","title":"Ubiquitin-Dependent ER Quality Control","description":"The terms cluster around ubiquitin-mediated proteostasis, especially ERAD, autoubiquitination, aggresome assembly, and regulation of ER-stress-induced apoptosis, pointing to a shared role in ER-associated protein quality control. Related terms on vesicle formation and organelle dynamics (mitochondrial fusion) and rRNA maturation likely reflect broader cellular housekeeping linked to proteostasis and trafficking.","confidence":"Medium","size":15,"edges":43,"triangles":64,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0017085","count":6},{"id":"GO:1902236","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0006357","count":6},{"id":"GO:0051865","count":6}]},{"hash":"1731057945411324937","title":"Unknown","description":"Top GO terms are diverse (BMP signaling, GI epithelium maintenance, sensory perception, coagulation, endothelial activation, metabolism, behavior) with no dominant shared function, so there is no coherent theme to name this cluster.","confidence":"","size":15,"edges":13,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030513","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030277","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0042381","count":1}]},{"hash":"51382430851714167","title":"P450-driven steroid and xenobiotic metabolism","description":"This cluster centers on cytochrome P450\u2013mediated metabolic processes, including steroid hormone biosynthesis (androgen, testosterone, ecdysone, calcitriol) and xenobiotic/organic compound catabolism (camphor, carbazole) linked by the omega-hydroxylase P450 pathway, with broader contextual terms like ozone response and maternal parturition that may reflect endocrine or stress-related regulation.","confidence":"Medium","size":15,"edges":10,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":5},{"id":"GO:0061370","count":5},{"id":"GO:0090350","count":4},{"id":"GO:0019383","count":4},{"id":"GO:0097267","count":4}]},{"hash":"1356020451893891024","title":"Vesicle trafficking and exosome secretion","description":"The terms cluster around endosome localization, ubiquitin-dependent sorting via multivesicular bodies, and exosomal secretion, with additional hints from cell adhesion and cilium assembly, suggesting a cohesive role in vesicle trafficking and intercellular communication rather than a single enzymatic function.","confidence":"Medium","size":15,"edges":58,"triangles":86,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0043162","count":1},{"id":"GO:1990182","count":1},{"id":"GO:0045752","count":1}]},{"hash":"1493643486185432419","title":"Arthropod cuticle and muscle morphogenesis","description":"The top GO terms cluster around chitin-based cuticle development and a suite of muscle-related processes, including cardiac/ventricular muscle contraction, regulation of muscle contraction, and regulation of muscle filament sliding speed, plus body morphogenesis. This points to a shared theme of arthropod development involving both exoskeletal formation and musculature, suggesting these proteins participate in coordinated morphogenesis of the cuticle and muscles. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":3},{"id":"GO:0010171","count":3},{"id":"GO:0043057","count":1},{"id":"GO:0032780","count":1},{"id":"GO:0060048","count":1}]},{"hash":"362560370822780367","title":"Carbohydrate Metabolism and Immune Signaling","description":"This cluster centers on carbohydrate-related processes (carbohydrate metabolism, N-acetylglucosamine metabolism, peptidyl-tyrosine sulfation) and immune/inflammatory mediator production with chemokine regulation, suggesting a link between sugar metabolism and immune signaling, possibly involving glycosaminoglycan-related modulation of the extracellular environment. Some terms are broad or obsolete, and a few reflect unrelated catabolic pathways, but the core motifs point to metabolism intertwined with inflammation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0090197","count":2}]},{"hash":"2038904763753892952","title":"Transmembrane transporters for ions and nucleosides","description":"The cluster is dominated by transmembrane transport GO terms, including sodium and potassium ion transport and transport of nucleosides (cytidine, purine, pyrimidine) and sugars (glucose, myo-inositol). While there are a couple of development-related terms, the prevailing pattern points to membrane transport activity, especially for ions and nucleosides, making this an apt, specific label.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0040003","count":1},{"id":"GO:0010171","count":1},{"id":"GO:0015861","count":1}]},{"hash":"1234188250047155884","title":"Telomere maintenance and DNA replication/repair","description":"The top GO terms point to telomere-specific processes (establishment of protein localization to telomere, telomere capping) and core genome stability activities (DNA replication, DNA repair, mitotic cell cycle checkpoint signaling). While some terms touch on translation and tRNA modification, the strongest cluster signal centers on telomere maintenance and genome integrity, justifying this label.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006468","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0007093","count":1},{"id":"GO:0070200","count":1},{"id":"GO:0006260","count":1}]},{"hash":"1334370893760319216","title":"P450-driven steroid and xenobiotic metabolism","description":"The cluster centers on steroid hormone biosynthesis/metabolism (androgen, ecdysone, calcitriol) and an omega-hydroxylase P450 pathway, with additional xenobiotic catabolic processes (camphor, carbazole). This pattern suggests cytochrome P450\u2013mediated metabolic roles that handle both endogenous hormone production and detoxification, with related themes in oxidative stress and hormonal regulation.","confidence":"High","size":15,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":15},{"id":"GO:0090350","count":15},{"id":"GO:0019383","count":15},{"id":"GO:0097267","count":15},{"id":"GO:0046232","count":15}]},{"hash":"578658742589767234","title":"Chitin-based cuticle development","description":"This cluster is dominated by GO terms related to chitin-based cuticle development and larval cuticle formation, with body morphogenesis also tying into developmental processes of the exoskeleton. The few other terms are less coherent with this theme, likely noise, but do not override the main signal of cuticle/morphogenesis.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":4},{"id":"GO:0010171","count":4},{"id":"GO:0009648","count":1},{"id":"GO:0001696","count":1},{"id":"GO:0045987","count":1}]},{"hash":"791206130923902534","title":"Immune Regulation and Development","description":"The cluster combines immune-related terms (innate immune response, T cell homeostasis, negative regulation of activated T cell proliferation, and NF-kappaB-related regulation) with developmental processes (embryonic placenta morphogenesis, spermatid nucleus differentiation) and cell division (spindle assembly). The presence of vitamin D response links to immune modulation, suggesting a theme around immune signaling intertwined with developmental contexts. Overall, the proteins seem enriched for immune regulation with ancillary roles in development and cell cycle processes, justifying a label that highlights both facets.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0060669","count":3},{"id":"GO:0033280","count":3},{"id":"GO:1901536","count":3},{"id":"GO:0043029","count":3}]},{"hash":"444076478144300716","title":"Larval chitin-based cuticle development","description":"The GO terms show larval chitin-based cuticle development and body morphogenesis, indicating involvement in forming the larval exoskeleton and shaping body structure, i.e., cuticle synthesis/assembly during development.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0010171","count":1}]},{"hash":"160332871112996508","title":"Embryonic organogenesis and neural development","description":"The Top Terms cluster around developmental processes across multiple tissues (forebrain, neural crest, cartilage, skeletal muscle, cochlea, ureteric bud) and associated regulation of gene expression and cell division, suggesting a broad developmental/morphogenesis program rather than a single pathway. This supports a label focusing on embryonic organ development and neural-related processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0048169","count":2},{"id":"GO:0021846","count":2},{"id":"GO:0090103","count":2}]},{"hash":"871532335797765057","title":"Proviral Integration and Latency","description":"The top GO terms point to DNA-level mobility and retroelement processes: DNA integration, RNA-templated DNA biosynthetic process, DNA transposition, and DNA replication/recombination, plus the specific emphasis on establishing integrated proviral latency. Although some terms touch on host entry or apoptosis, the dominant theme is proviral DNA integration and latency, suggesting a cluster of proteins involved in retroviral integration and latency control.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0075732","count":8},{"id":"GO:0075713","count":8},{"id":"GO:0046718","count":8},{"id":"GO:0039651","count":8}]},{"hash":"224205914377979241","title":"Mitochondrial transport and metabolism","description":"The top GO terms cluster around importing and transporting mitochondrial cofactors and nucleotides (pyridoxal phosphate, NAD, CoA, pyrimidine nucleotides) and include redox/oxidative stress responses and necroptosis regulation, which together point to a coherent function in mitochondrial metabolism and redox homeostasis rather than a single tissue process. Liver regeneration and pregnancy terms may reflect systemic metabolic context rather than direct mitochondrial transport functions.","confidence":"High","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097421","count":10},{"id":"GO:0031921","count":9},{"id":"GO:0061179","count":9},{"id":"GO:1990519","count":9},{"id":"GO:0035349","count":9}]},{"hash":"1315883548204334097","title":"RNA processing and translation regulation","description":"This cluster is named to reflect the strong representation of post-transcriptional RNA processing terms (mRNA splicing via spliceosome and regulation of alternative splicing) together with translation control terms (translation reinitiation, preinitiation complex formation, and miRNA-mediated translational repression), indicating a cohesive group involved in RNA processing and subsequent translation regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0002188","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0006378","count":8},{"id":"GO:0010610","count":7}]},{"hash":"840274991004538385","title":"Developmental Growth and Signaling","description":"Enriched terms cluster around developmental processes across tissues (skin, retina, multicellular development) and regulation of cell proliferation and signaling (GTPase activity), suggesting proteins involved in developmental growth and its signaling controls. Temperature-related terms may reflect stress-linked modulation but do not override the core developmental theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0043588","count":5}]},{"hash":"116850701517578654","title":"Innate immune signaling and leukocyte activation","description":"The top GO terms cluster around innate immune pathways: lectin-mediated complement activation, C-type lectin and Fc receptor signaling, phagocytosis, basophil activation, and NK cell regulation, plus related platelet activation. While there are a couple developmental terms (lymphangiogenesis, cartilage condensation), the dominant signal is immune activation and leukocyte signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0036303","count":4},{"id":"GO:0090403","count":4},{"id":"GO:0002223","count":4},{"id":"GO:0006910","count":4}]},{"hash":"1727490331997000068","title":"BMP-regulated tissue development and growth control","description":"This cluster centers on developmental signaling and remodeling, highlighted by BMP signaling regulation, chondrocyte differentiation, and control of growth and muscle development. Mammary gland involution further suggests tissue remodeling, while a few digestive terms appear less coherently connected. Overall, the common theme is BMP-associated developmental regulation and tissue remodeling rather than a single tissue type.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044258","count":1},{"id":"GO:0030157","count":1},{"id":"GO:0018350","count":1},{"id":"GO:0002062","count":1},{"id":"GO:1902731","count":1}]},{"hash":"1853999849578366737","title":"Unknown","description":"The top GO terms cover a wide range of processes (embryonic/placental development and angiogenesis, digestion, transcription regulation, neuronal plasticity, and immune activation) with no single cohesive function tying the cluster together. This diversity makes it unclear to assign a focused, representative label.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048168","count":3},{"id":"GO:0097274","count":2},{"id":"GO:0007586","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0001824","count":2}]},{"hash":"928863027982268606","title":"Inflammatory Mediator Production and Chemokine Regulation","description":"The cluster is characterized by GO terms linked to inflammatory response and chemokine production (GO:0002532, GO:0090197), indicating immune signaling activity. While there are also metabolic terms (GO:0006032, GO:0005975), the immune-related terms are prominent, supporting a label centered on inflammatory mediator production and chemokine regulation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0005975","count":2}]},{"hash":"2259445515689957393","title":"Unknown","description":"The top GO terms are from highly diverse biological processes (cell cycle regulation, TGF-\u03b2 production, sperm motility, neural development, photoreceptor organization, axon sprouting, ventricular development, chemotaxis, apoptosis, keratinization), with no clear shared function or dominant theme among the proteins. Because there is no cohesive biological signal tying the cluster together, a specific label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010389","count":2},{"id":"GO:0032915","count":1},{"id":"GO:0030317","count":1},{"id":"GO:0021891","count":1},{"id":"GO:0035845","count":1}]},{"hash":"292995671526690788","title":"Protein homooligomerization and ubiquitination","description":"This cluster centers on protein self-assembly and post-translational tagging, implying roles in regulating protein complexes and turnover. The evidence is sparse (two terms, no edges), so the connection is tentative.","confidence":"Low","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":1},{"id":"GO:0016567","count":1}]},{"hash":"20679793492015581","title":"Neural development and signaling","description":"This cluster is dominated by terms tied to brain development and neural differentiation (forebrain development, Bergmann glial cell differentiation) along with signaling pathways (Wnt signaling, peptidyl-tyrosine autophosphorylation, PDGF response). Although there are some immune-related terms present, the prominent neural development and signaling terms suggest a brain development-oriented group.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002774","count":13},{"id":"GO:0002333","count":13},{"id":"GO:2001275","count":13},{"id":"GO:1900086","count":13},{"id":"GO:0060020","count":13}]},{"hash":"529533951651754466","title":"Retroviral DNA Integration and Latency","description":"Several top GO terms directly describe steps in the retroviral lifecycle, including DNA replication, DNA integration, RNA-templated DNA biosynthesis (reverse transcription), and establishment of integrated proviral latency, as well as viral penetration into the host nucleus. These converge on a coherent theme of retroviral genome incorporation and persistence in the host, with some additional terms related to host-symbiont interactions that appear ancillary. Overall, the cluster appears dominated by retroviral integration/latency biology.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2}]},{"hash":"957079347583136167","title":"Embryonic and Organ Development","description":"This cluster highlights development across multiple tissues\u2014neural development (axon guidance, neural tube closure), cardiac organogenesis (ventricular smooth/cardiac muscle development, hypertrophy regulation), hair follicle formation, and pancreatic islet cell development\u2014often linked through growth and signaling pathways like PI3K/AKT. The lack of a single cohesive function and the presence of diverse tissue-specific development terms justify a broad developmental label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071679","count":2},{"id":"GO:0010693","count":2},{"id":"GO:0046676","count":2},{"id":"GO:0055015","count":2},{"id":"GO:0001942","count":2}]},{"hash":"1183452760125349738","title":"Sodium and Potassium Ion Transport","description":"The top GO terms show sodium ion transmembrane transport and potassium ion transmembrane transport (2 mentions each), pointing to a shared role in membrane ion movement. Other terms suggest signaling and trafficking, but the dominant, coherent theme across the cluster is transmembrane ion transport, justifying the label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0035021","count":1},{"id":"GO:0032760","count":1},{"id":"GO:0060396","count":1}]},{"hash":"2037908387160732781","title":"Endolysosomal trafficking and acidification","description":"The top GO terms cluster around endosome transport, vacuolar ATPase assembly, and vacuolar/vesicle lumen acidification, along with related synaptic vesicle organization and signaling (Rho pathways). Together these point to a cohesive module governing vesicle trafficking and pH regulation inside the cell, with some developmental terms likely reflecting broader regulatory roles rather than a shared developmental function. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0045022","count":1},{"id":"GO:0070072","count":1},{"id":"GO:0007035","count":1}]},{"hash":"1899861609822324102","title":"Diverse metabolite biosynthesis and hormone metabolism","description":"This cluster's top GO terms include biosynthetic processes for several different metabolites (poly-hydroxybutyrate, mycolic acid, phylloquinone, tropane alkaloids) along with hormone biosynthesis (androgen, estrogen), plus related regulatory and stress/response terms. The common theme appears to be involvement in biosynthesis and metabolism of diverse metabolites across systems, rather than a single, unified pathway, supporting this label. ","confidence":"Medium","size":14,"edges":40,"triangles":42,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":11},{"id":"GO:0055114","count":11},{"id":"GO:0006355","count":9},{"id":"GO:0008209","count":8},{"id":"GO:0006703","count":8}]},{"hash":"1983623224427700020","title":"Cell Migration and Morphogenesis","description":"Most represented GO terms point to cellular movement and tissue formation, including axon extension/guidance, fibroblast migration, and B cell chemotaxis, along with embryo development and coronary artery morphogenesis. While there are additional stress-related terms (hypoxia, xenobiotic response), they are less central. This suggests the cluster groups proteins involved in migration and morphogenesis processes.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0048846","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0035754","count":3},{"id":"GO:0032496","count":3}]},{"hash":"1996991267735211672","title":"Embryonic Development and Morphogenesis","description":"This cluster shows proteins linked to broad embryonic development and tissue formation processes, including neural crest migration, midbrain development, pancreas development, cartilage formation, and various morphogenesis events (digestive tract, ureteric bud branching, endocardial EMT). The presence of transcription-related GO terms (DNA-templated transcription, negative regulation of transcription by RNA Pol II) suggests regulatory roles during development. Together, these terms point to a cohesive theme of developmental regulation and morphogenesis.","confidence":"High","size":14,"edges":6,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0048557","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0031018","count":3}]},{"hash":"897047882445376041","title":"Redox metabolism and nitrosative stress response","description":"The cluster includes redox-related terms (oxidation-reduction) alongside nitrosative stress response and S-nitrosylation, plus a mix of metabolic pathways (ethanol and sorbitol catabolism, retinol and lignin biosynthesis). This points to a cohesive theme of redox-enabled metabolism and nitrosative signaling across the proteins.","confidence":"High","size":14,"edges":45,"triangles":55,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0042572","count":3},{"id":"GO:0019518","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0006069","count":2}]},{"hash":"2208826488583491130","title":"Nuclear transport and transcription regulation","description":"The top GO terms cluster around nuclear processes: multiple entries for protein import into the nucleus and NPC assembly point to a shared role in nuclear transport, while terms related to transcription regulation (negative regulation of transcription by RNA polymerase II and CpG methylation\u2013mediated gene silencing) indicate involvement in gene expression control. Together, these suggest a coherent function in nuclear transport coupled with transcription regulation.","confidence":"High","size":14,"edges":8,"triangles":3,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0060188","count":6},{"id":"GO:0006610","count":6},{"id":"GO:0000060","count":6},{"id":"GO:0043547","count":6}]},{"hash":"1637927318747336271","title":"Embryonic and Neural Development","description":"The cluster\u2019s top GO terms are dominated by developmental processes across multiple organs and neural structures: heart, cerebellum, forebrain, retinal pathways/visual perception, motor neuron axon guidance, placenta, and thyroid development, with a minor note of activated T cell proliferation. This points to a cohesive theme of broad developmental programs, especially neural development, rather than a single tissue-specific function. The immune term appears as a minor outlier. ","confidence":"High","size":14,"edges":15,"triangles":3,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0050798","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0021549","count":2}]},{"hash":"1056159186002530831","title":"Extracellular Matrix Remodeling and Innate Immune Activation","description":"The top terms cluster around collagen catabolic processes and regulation of fibrinogen, suggesting extracellular matrix remodeling and coagulation. At the same time, multiple terms point to innate immunity (complement activation pathways, Toll signaling, and response to yeast), with amelogenesis adding a biomineralization context tied to extracellular matrices. This combination supports a theme of ECM remodeling coupled with innate immune activity, with biomineralization aspects. Confidence: Medium","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030574","count":5},{"id":"GO:0042127","count":5},{"id":"GO:0006958","count":5},{"id":"GO:0001867","count":5},{"id":"GO:1902947","count":4}]},{"hash":"617465595934349887","title":"Unknown","description":"The top GO terms span hormone/stress responses, immune stimulus response, development, various metabolic and epigenetic processes, and there isn\u2019t a clear, single-function theme tying them together. Therefore a specific, representative label with confidence cannot be assigned.","confidence":"","size":14,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051412","count":5},{"id":"GO:2000648","count":3},{"id":"GO:0009228","count":3},{"id":"GO:0051573","count":3},{"id":"GO:0033514","count":3}]},{"hash":"1034379765946877859","title":"Unknown","description":"The GO terms span highly diverse processes (angiogenesis, RNA splicing, ribosome biogenesis, innate defense, phosphorylation signaling, cuticle/molting, proteolysis, muscle growth regulation, developmental axis specification, and sperm binding). There isn't a single cohesive theme binding these functions, so a specific, interpretable label isn\u2019t justifiable.","confidence":"","size":14,"edges":46,"triangles":42,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0050731","count":2}]},{"hash":"1988100900183536280","title":"Neural development and axon guidance","description":"The proteins show a concentration of GO terms tied to nervous system development and connectivity, including neural crest cell migration, facial/acoustic ganglion development, vestibulocochlear nerve organization, cerebellar cortex development, axon extension, synapse maturation, and regulation of synaptic plasticity. There is one outlier term for larval chitin-based cuticle development, suggesting a potential annotation noise, but the dominant theme is neural development and axon guidance.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0035767","count":2},{"id":"GO:0060074","count":1},{"id":"GO:1901166","count":1},{"id":"GO:1903375","count":1}]},{"hash":"1406241014376048780","title":"Immune Signaling and Cytoskeletal Regulation","description":"Our top GO terms show B cell receptor signaling, interleukin-2 production, and dendritic cell differentiation, all pointing to immune cell signaling. Additional terms point to cytoskeletal remodeling (Rho signaling, GTPase activity, lamellipodium assembly) which commonly accompany immune cell activation and adhesion. Taken together, the cluster appears to be centered on immune signaling with concurrent cytoskeletal and adhesion dynamics.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0006351","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0035023","count":3}]},{"hash":"959949665785028596","title":"ER stress-induced apoptosis and translation regulation","description":"Based on the GO terms, this cluster centers on the endoplasmic reticulum (ER) stress response and mitochondria-mediated apoptosis, with emphasis on unfolded protein response, regulation of translation initiation during ER stress, and cytochrome c release. The combination suggests proteins that couple the UPR to intrinsic apoptotic signaling while modulating translation, indicating a cohesive ER stress\u2013driven apoptotic/translational control function.","confidence":"High","size":14,"edges":87,"triangles":322,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0090200","count":2},{"id":"GO:0034393","count":1},{"id":"GO:0043280","count":1},{"id":"GO:0097193","count":1}]},{"hash":"551302214157157093","title":"Nuclear transcription and RNA processing","description":"The cluster shows strong ties to nuclear gene expression control and RNA maturation, with GO terms including snoRNA localization, box C/D snoRNP assembly, chromatin remodeling, regulation of histone deacetylation, transcription regulation and termination, and nonsense-mediated mRNA decay. While a few terms touch on the cell cycle or apoptosis, the dominant theme centers on nuclear RNA processing and transcriptional regulation, suggesting these proteins function together in RNA-based gene expression maintenance. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048254","count":1},{"id":"GO:0006338","count":1},{"id":"GO:0031063","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0000492","count":1}]},{"hash":"2279073403441201672","title":"Ribosome biogenesis and translation initiation","description":"This cluster centers on ribosome assembly and the initiation of protein synthesis, with GO terms for ribosomal large subunit biogenesis, maturation of LSU rRNA, and formation of the translation preinitiation complex, plus DNA-templated transcription. A few other terms (skin development, xylan catabolic process, allantoin and lipid A biosynthesis) seem less connected and may reflect annotation noise. Overall, the dominant theme is the gene-expression machinery related to ribosome biogenesis and translation initiation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0043588","count":2}]},{"hash":"531524077828586852","title":"Diverse Transmembrane Transporters","description":"The cluster\u2019s top GO terms are dominated by transmembrane transport activities for a wide range of substrates (xenobiotics, nitrate/nitrite, galactose, sodium, phosphate, vitamins) and related processes such as neurotransmitter loading into synaptic vesicles. This points to proteins functioning as membrane transporters handling diverse solutes, rather than a single metabolic or catalytic role, justifying the label \u201cDiverse Transmembrane Transporters.\u201d","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0015757","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0035725","count":2}]},{"hash":"1535913712322036279","title":"DNA repair and retroviral integration factors","description":"This cluster is dominated by GO terms for DNA metabolism and handling (DNA recombination, replication, base-excision repair, DNA integration) along with retroviral processes (viral penetration into the host nucleus and proviral latency). The presence of xenobiotic response and cell-cycle regulation hints at broader stress-responsive functions, but the core pattern is DNA repair/processing linked to retroviral integration events.","confidence":"High","size":14,"edges":60,"triangles":109,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0042493","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0007568","count":4},{"id":"GO:0006284","count":4}]},{"hash":"1665576965014762064","title":"Retroviral DNA integration and proviral latency","description":"Most terms converge on retroviral life cycle steps: DNA replication, recombination, and integration; viral entry into the host nucleus and proviral latency establishment; plus RNA-templated DNA biosynthesis, i.e., reverse transcription. The inclusion of symbiont entry and host apoptosis activation aligns with host\u2013pathogen interactions, and negative regulation of siRNA processing hints at antiviral defense involvement. Together, these suggest a cohesive theme around retroviral genome integration and maintenance within the host. ","confidence":"High","size":14,"edges":40,"triangles":77,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006310","count":6},{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0075713","count":5}]},{"hash":"143859626138052244","title":"Immune and nervous system signaling cluster","description":"The top GO terms point to multiple signaling cascades (T cell receptor signaling, TRK/neurotrophin signaling, JNK cascade, TGF-beta response) and processes in immunity and nervous system development, with additional links to platelet formation and heart development, suggesting a set of proteins involved in broad signal transduction coordinating immune and neural developmental functions. This supports a label centered on immune and nervous system signaling, rather than a single narrow pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0048011","count":2},{"id":"GO:0071560","count":2}]},{"hash":"410500948808109359","title":"Viral integration and host cell cycle","description":"The cluster\u2019s top GO terms center on viral entry into the host nucleus, establishment of proviral latency, and DNA integration, which point to retroviral-like genome integration. The presence of cell-cycle related terms (cell division, mitotic spindle assembly) suggests a link between these viral processes and host cell proliferation. Additional terms about symbiont entry and activation of host apoptosis reinforce a broader theme of pathogen-host interactions affecting the host cell state. ","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3}]},{"hash":"2098124483169948829","title":"Neural Development and Axon Guidance","description":"The top GO terms center on nervous system development and guidance of neuronal processes: axon guidance, ROBO signaling pathway, hippocampus development, cochlea morphogenesis, and general nervous system development. A few terms about ossification and spermatid development appear, but the dominant pattern points to neural/sensory tissue morphogenesis and guidance signaling. Given no network edges, the label reflects a shared functional theme rather than demonstrated interactions, which supports grouping these proteins as neural development\u2013related.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":2},{"id":"GO:0090103","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0002551","count":2},{"id":"GO:0007399","count":2}]},{"hash":"1288928274351101069","title":"Drug- and Inflammatory Signaling Modulation","description":"The cluster centers on responses to morphine and xenobiotics, coupled with regulation of inflammation and signaling pathways (ERK1/2 cascade, GTPase activity). This suggests a cohesive theme of drug/xenobiotic response intertwined with inflammatory signaling and MAPK/GTPase regulation, with some tissue-specific signals like chondrocyte development that contextualize the signaling network.","confidence":"Medium","size":14,"edges":10,"triangles":7,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043278","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0050728","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0043547","count":4}]},{"hash":"447619300608687184","title":"Unknown","description":"This cluster lists GO terms from very different biological areas: angiogenesis (endothelial proliferation in sprouting), SA node to atrial cardiac muscle communication, cell cycle, vasopressin secretion, cerebellar granule cell differentiation, hepatocyte apoptotic process, protein poly-ADP-ribosylation, pain perception, negative regulation of IL-12 production, and telomere binding regulation. The diversity suggests no single cohesive function or pathway ties the proteins together, and there are no edges or triangles to indicate direct interactions, so a unified functional label isn\u2019t supported.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":2},{"id":"GO:0086070","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0030103","count":2},{"id":"GO:0021707","count":2}]},{"hash":"2108211603121932218","title":"Adrenergic, dopaminergic, and opioid GPCR-cAMP signaling","description":"The top GO terms cluster around GPCR signaling that modulates adenylate cyclase and cAMP levels via adrenergic, dopaminergic, and opioid receptors, indicating a shared GPCR-cAMP signaling mechanism. The presence of terms related to blood pressure regulation, heart development, inflammatory response, and dendritic cell differentiation suggests the pathway's relevance across cardiovascular and immune contexts, consistent with a unified signaling module controlling diverse physiological processes through GPCR-cAMP cascades.","confidence":"High","size":14,"edges":60,"triangles":130,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0051482","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0071880","count":4}]},{"hash":"993050828941644390","title":"Telomere maintenance and telomeric localization","description":"Most terms cluster around telomere biology: maintenance via telomerase, localization to telomeric regions, and telomere capping, complemented by PARP-related (ADP-ribosylation) regulation of proteins. A minority of terms pertain to broader developmental processes, but the telomere-centric signals dominate.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0070212","count":3},{"id":"GO:0032212","count":3}]},{"hash":"1471563417324267728","title":"Unknown","description":"The top GO signals are sparse and include one dubious term (\"heart jogging\") and one precise term for axonemal dynein complex assembly, but there is no evident, shared function tying all 14 proteins together, and the network shows no edges or structure. There isn\u2019t a clear, representative label to assign.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003146","count":1},{"id":"GO:0070286","count":1}]},{"hash":"1165817651839282801","title":"Plasma membrane sugar transporters","description":"This cluster is strongly enriched for GO terms related to import and transport of sugars (fructose, glucose, xylose, trehalose) across the plasma membrane, as well as cellular responses to sugar stimuli and nutrient starvation. While a few terms touch on other metabolite transport or senescence, the dominant theme is membrane-associated sugar uptake, suggesting a functional group of sugar transport proteins and related nutrient-sensing components.","confidence":"High","size":14,"edges":23,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1990539","count":14},{"id":"GO:0044381","count":14},{"id":"GO:0019852","count":14},{"id":"GO:0015753","count":14},{"id":"GO:0052106","count":14}]},{"hash":"529695430636284211","title":"Neural development and synaptic plasticity regulation","description":"The GO terms cluster around neuronal development (lateral line development, cerebellar granule cell differentiation) and memory-related processes (long-term and medium-term memory, olfactory learning), plus modulation of synaptic transmission and plasticity (positive/negative regulation). This points to a cohesive theme of neural development with activity-dependent synaptic regulation rather than unrelated functions.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050806","count":3},{"id":"GO:0048915","count":3},{"id":"GO:0048899","count":3},{"id":"GO:0048172","count":3},{"id":"GO:0051967","count":3}]},{"hash":"2238730153409379120","title":"Cardiac muscle contraction and electrical conduction","description":"Proteins in this cluster are enriched for GO terms tied to cardiac physiology, including cardiac muscle contraction, regulation of atrial and ventricular muscle membrane depolarization and repolarization, and heart rate regulation via cardiac conduction. This supports a label focused on cardiac electrical activity and contractile function. Some non-cardiac terms present may reflect annotation noise, but the dominant cardiac theme prevails.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0086016","count":2},{"id":"GO:0001964","count":2},{"id":"GO:0060307","count":2}]},{"hash":"1119667404828222604","title":"Developmental and vascular signaling","description":"These proteins collectively show enrichment for multiple signaling and development-related GO terms, including GPCR signaling, Wnt signaling, brain development, angiogenesis, thrombin receptor signaling, and cardiac cell communication. While there is no single dominant process, the common thread is participation in developmental signaling pathways and vascular/cardiac interactions, making \"Developmental and vascular signaling\" a concise, representative label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0007420","count":2}]},{"hash":"256023952653400499","title":"Telomere maintenance and cell cycle regulation","description":"The dominant GO terms cluster around telomere maintenance via telomerase and regulation of telomerase activity, along with a clear cell cycle signal, supported by protein stabilization. While other terms (heat response, mechanical stimulus, angiogenesis, differentiation signals) appear, they are ancillary to the core telomere/cell-cycle theme. So the cluster is best described as telomere maintenance and cell cycle regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051973","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0050821","count":2},{"id":"GO:0009408","count":2}]},{"hash":"1333508834261274252","title":"Muscle development and signaling","description":"Top terms cluster around skeletal muscle fiber development, responses to muscle stretch and activity, and regulation of heart conduction, with related signaling like cAMP and caffeine response. A few terms are unrelated (skin development, sweet taste), but the dominant theme supports a muscle-focused cluster label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0046000","count":1}]},{"hash":"1227412560352316414","title":"AMPA receptor clustering and synaptic potentiation","description":"This cluster\u2019s GO terms converge on glutamatergic synapse organization and plasticity, notably regulation of AMPA receptor clustering and positive regulation of long-term potentiation, with GKAP (guanylate kinase-associated protein) clustering reinforcing postsynaptic density involvement. A few outlier terms (immune, heart development, peroxisomal import) appear, but the strongest signals point to synaptic remodeling functions.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030890","count":2},{"id":"GO:0030218","count":1},{"id":"GO:0055072","count":1},{"id":"GO:1903764","count":1},{"id":"GO:0016560","count":1}]},{"hash":"1876367834000977573","title":"Notch Signaling and Organ Morphogenesis","description":"The cluster is enriched for Notch signaling and several organ morphogenesis terms (cardiac left ventricle formation, ascending aorta morphogenesis, stomatal complex development), suggesting a theme of developmental signaling guiding organogenesis across tissues. While other terms like SREBP signaling or hair cycle regulation appear, the Notch+morphogenesis pattern is the most coherent across the top terms, supporting a developmental-morphogenesis label with moderate confidence.","confidence":"Medium","size":13,"edges":56,"triangles":149,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0043433","count":13},{"id":"GO:0010374","count":10},{"id":"GO:0045668","count":10},{"id":"GO:0032933","count":10},{"id":"GO:0035910","count":10}]},{"hash":"2261625627932513014","title":"Extracellular matrix remodeling and tissue development","description":"The cluster\u2019s top GO terms cluster around remodeling and breakdown of extracellular matrix components (basement membrane disassembly, collagen catabolic process, bone resorption, intramembranous ossification) and developmental processes (lung branching morphogenesis, decidualization). Additional terms like thyroid hormone response and immune-related T cell cytotoxicity appear, but the strongest signal is ECM remodeling coupled with morphogenesis across tissues. This suggests proteins involved in matrix restructuring during development and tissue remodeling rather than a single, narrow function.","confidence":"Medium","size":13,"edges":67,"triangles":193,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0046697","count":12},{"id":"GO:0001913","count":12},{"id":"GO:0045453","count":12},{"id":"GO:0010813","count":12},{"id":"GO:0001957","count":12}]},{"hash":"1754418221564899284","title":"RNA and Protein Methyltransferases","description":"Top GO terms converge on RNA methylation (rRNA, tRNA) and various protein methylations (peptidyl-lysine/arginine), plus chromatin-associated methylation, indicating a cohesive set of methyltransferases acting on RNA, proteins, and chromatin.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":9},{"id":"GO:0018027","count":9},{"id":"GO:0018013","count":8},{"id":"GO:0018023","count":6},{"id":"GO:0000183","count":6}]},{"hash":"400546430072874971","title":"Unknown","description":"The top GO terms cover diverse areas: differentiation regulation (megakaryocyte differentiation, stem cell proliferation, neuron maturation), signaling (cellular response to cAMP), and distinct metabolic processes (thiamine biosynthesis, tetrahydrofolate metabolism) plus hormone biosynthesis. There isn\u2019t a single cohesive biological theme that ties these terms together, suggesting the cluster reflects a heterogeneous mix of regulatory and metabolic functions rather than a specific pathway. ","confidence":"","size":13,"edges":13,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045654","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0046653","count":4},{"id":"GO:0060992","count":4},{"id":"GO:2000648","count":4}]},{"hash":"1949260900406787264","title":"Embryonic development and organ morphogenesis","description":"The terms center on embryonic development and organ morphogenesis, including pancreas and palate development, cartilage formation, left-right patterning, and heart-related EMT events; together they depict broad developmental processes shaping tissues during embryogenesis.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009791","count":4},{"id":"GO:0061113","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0060021","count":3},{"id":"GO:0035270","count":3}]},{"hash":"1414932276153364826","title":"Adaptive immune cell differentiation and signaling","description":"Top terms are dominated by adaptive immunity processes: positive regulation of dendritic cell differentiation, B cell receptor signaling pathway, positive regulation of pro-T cell differentiation, regulation of memory T cell differentiation, and germinal center formation. Together these indicate lymphocyte development and activation (B/T cells and dendritic cells). Some unrelated terms (phototropism, gravitropism) and ubiquitination appear but do not define the cluster\u2019s core function. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":7},{"id":"GO:0050853","count":7},{"id":"GO:1900477","count":6},{"id":"GO:0043380","count":6},{"id":"GO:0032764","count":6}]},{"hash":"1524778239783703573","title":"Organogenesis signaling and neural development","description":"The cluster is enriched with hedgehog (smoothened) signaling, BMP signaling, Robo/Roundabout pathways, and terms for nervous system, forebrain migration, heart and kidney development, and cell adhesion, pointing to proteins coordinating developmental signaling and organogenesis, particularly neural patterning and tissue morphogenesis. Some terms like T cell signaling or iron homeostasis are outliers, but the dominant theme is developmental signaling networks.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0001822","count":9},{"id":"GO:0050852","count":8},{"id":"GO:0007507","count":8}]},{"hash":"760945607142107822","title":"Unknown","description":"The cluster\u2019s top GO terms span very different biological contexts, including skeletal muscle fiber development, substantia nigra development, various carbohydrate and ethanol/metabolite catabolic processes, nitrosative stress responses and protein S-nitrosylation, copper ion response, and even plant-specific lignin biosynthesis, plus general extracellular regulation of signaling. There isn\u2019t a clear, single function or pathway tying these terms together, so a cohesive label isn\u2019t justifiable.","confidence":"","size":13,"edges":47,"triangles":81,"max_degree":11,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0048741","count":5},{"id":"GO:0021762","count":5},{"id":"GO:0006069","count":4},{"id":"GO:0051409","count":4},{"id":"GO:0006062","count":4}]},{"hash":"1482283964184051247","title":"Diverse specialized metabolite biosynthesis","description":"This cluster\u2019s top GO terms cluster around biosynthetic processes for diverse specialized compounds (antibiotics, steroids/hormones, vitamins, alkaloids, and cell-wall mycolic acids) as well as related drug responses. While the specific pathways are diverse and organism-specific, the shared thread is synthesis of complex metabolites rather than broad cellular functions, supporting a broad \u201cdiverse specialized metabolite biosynthesis\u201d label.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0008209","count":2},{"id":"GO:0006703","count":2}]},{"hash":"1741442283764899240","title":"Insulin/IGF signaling and metabolic regulation","description":"The cluster is dominated by terms related to insulin receptor signaling, IGF signaling, and glucose import in response to insulin, along with fatty acid beta-oxidation, indicating a core role in insulin/IGF-driven metabolism and growth. Additional enrichment for chaperone-mediated protein complex assembly and ubiquitin-dependent proteolysis suggests involvement in proteostasis to support these signaling and metabolic processes. Some growth- and immune-related terms (TGF-beta signaling, B cell homeostasis) appear, but the central theme remains insulin/IGF signaling and metabolic regulation.","confidence":"Medium","size":13,"edges":44,"triangles":70,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":3},{"id":"GO:0051131","count":3},{"id":"GO:0030511","count":3},{"id":"GO:0001782","count":2},{"id":"GO:0042787","count":2}]},{"hash":"1862030577457816626","title":"Oxidative stress detox and prostaglandin-inflammatory signaling","description":"The cluster is dominated by GO terms for cellular oxidant detoxification, response to toxic substances, and prostaglandin biosynthesis, with additional signals of inflammatory regulation and glucocorticoid response. This points to a theme of handling oxidative stress and lipid mediator\u2013driven inflammation, despite a few peripheral terms (like smell perception) that may reflect broader gene family associations.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":8},{"id":"GO:0001516","count":7},{"id":"GO:0009636","count":6},{"id":"GO:0002674","count":6},{"id":"GO:0071460","count":6}]},{"hash":"2028116225639768298","title":"Transmembrane Transporters","description":"The GO terms are dominated by transmembrane transport activities across membranes, covering ions (K+, Na+), nitrite/nitrate, sugars (galactose), vitamins, xenobiotics, and related metabolic processes. The inclusion of neurotransmitter loading into synaptic vesicles further points to transporter-related roles rather than steady-state metabolism alone. Overall, the cluster appears to represent membrane transporters and transporter-associated functions.","confidence":"High","size":13,"edges":32,"triangles":35,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0015757","count":3},{"id":"GO:0015706","count":3}]},{"hash":"1740390704040061986","title":"Larval chitin-based cuticle development","description":"This cluster is enriched for the GO term larval chitin-based cuticle development, with 7 of 13 proteins annotated to this process, strongly pointing to a shared role in forming or remodeling the larval cuticle via chitin metabolism. The cluster likely comprises cuticle-related proteins and enzymes involved in chitin synthesis/remodeling.","confidence":"High","size":13,"edges":16,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":7}]},{"hash":"236820885089554713","title":"Diverse Transmembrane Transport","description":"The proteins cluster around transmembrane transport activities, with GO terms spanning uridine, thymine, nitrate, galactose, sodium ions, vitamins, and xenobiotics, plus related metabolic processes. This points to a common theme of membrane transport of diverse substrates, suggesting roles as transporters or transport-associated factors rather than a single-substrate function.","confidence":"High","size":13,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010909","count":2},{"id":"GO:0015862","count":1},{"id":"GO:0035364","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1}]},{"hash":"643619614703674248","title":"mRNA Splicing and Translation Control","description":"The cluster\u2019s top GO terms center on spliceosome-mediated mRNA processing (alternative splicing and general splicing) and on initiation/reinitiation of translation, with additional signals of miRNA-mediated translational repression. This points to a cohesive role in post-transcriptional regulation, coordinating mRNA maturation with the start of protein synthesis. A few terms are listed as obsolete, but the main pattern remains clear.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000380","count":5},{"id":"GO:0006378","count":4},{"id":"GO:0045292","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4}]},{"hash":"105015597982555531","title":"Membrane trafficking and adhesion regulation","description":"The cluster is dominated by GO terms related to protein localization to the plasma membrane and rafts, endocytosis, and regulation of cadherin-mediated cell\u2013cell adhesion, pointing to a cohesive role in membrane dynamics and adhesion processes. A dsRNA response term appears but does not define the overall theme; the core signal is membrane trafficking/adhesion modulation with a minor mitochondrial membrane note. ","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071360","count":2},{"id":"GO:0045861","count":2},{"id":"GO:0044860","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0034116","count":2}]},{"hash":"168558804313297504","title":"Sensory Neuron Development and Synaptic Transmission","description":"This label fits because the top GO terms cluster around neural development (cerebellar granule cell differentiation, lateral line development) and sensory systems (sound perception) as well as synaptic signaling (ionotropic glutamate receptor signaling, regulation and enhancement of synaptic transmission, short-term plasticity), with neuromodulation by serotonin providing context. A small number of terms about cuticle development appears as an outlier.","confidence":"High","size":13,"edges":17,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0042428","count":3},{"id":"GO:0035235","count":3},{"id":"GO:0045988","count":2}]},{"hash":"2062805198839949640","title":"Unknown","description":"There are no Top Terms provided, so there is no apparent shared function or pathway linking the proteins. Without GO terms or functional signals, it's not possible to assign a meaningful label; therefore the cluster is best described as Unknown.","confidence":"","size":13,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[]},{"hash":"360148876151323681","title":"Embryonic neural patterning and gonadogenesis","description":"The terms point to neural development (nodal signaling, cerebral cortex regionalization, somitogenesis) and male reproductive organ development (Sertoli cells, spermatid elongation, male sex determination, male gonad development, germ cell proliferation), with odontogenesis as an additional organogenesis example. This suggests a broad embryonic development theme centered on neural patterning and gonadal formation, rather than a single pathway. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900107","count":3},{"id":"GO:0021796","count":2},{"id":"GO:0060009","count":2},{"id":"GO:0007290","count":2},{"id":"GO:0042487","count":2}]},{"hash":"2046049808164687958","title":"N-terminal and polyamine acetylation","description":"The top GO terms cluster around acetylation and related modifications, including N-terminal acetylation (glutamic acid, methionine), propionylation, and acetylation of polyamines (putrescine, spermine). This points to a shared role in post-translational modification by acetylation. Some unrelated terms (leaf formation, angiogenesis, chromatin formation, arginine biosynthesis) may reflect annotation noise or multifunctional proteins. Overall, the proteins appear connected by acetylation-related modification activity.","confidence":"Medium","size":13,"edges":13,"triangles":8,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2000025","count":3},{"id":"GO:0032920","count":3},{"id":"GO:0006044","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0006348","count":3}]},{"hash":"1371033075436427827","title":"Actin Cytoskeleton Remodeling and Endocytosis","description":"This cluster is strongly enriched for GO terms tied to actin dynamics (branching, filopodia, ruffles, polymerization) and small GTPase\u2013mediated signaling, with concurrent endocytosis and cell polarity/shaping regulatory processes. The presence of T cell receptor and ephrin receptor signaling terms suggests these proteins participate in signaling pathways that drive cytoskeletal remodeling, endocytosis, and cell shape changes.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090135","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0048013","count":2},{"id":"GO:0043552","count":2}]},{"hash":"582626174096595883","title":"Ion and Nutrient Transmembrane Transporters","description":"The top GO terms are dominated by transmembrane transport for ions, nutrients, and xenobiotics (potassium, sodium, nitrate/nitrite, galactose, vitamins, fucose) with an additional note on neurotransmitter loading into synaptic vesicles, indicating a cluster of membrane transporter proteins handling diverse substrates.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0006855","count":4},{"id":"GO:0042128","count":4},{"id":"GO:0015757","count":4},{"id":"GO:0015706","count":4}]},{"hash":"1923810555841064829","title":"Proteostasis and Cell Cycle Regulation","description":"The cluster is dominated by ubiquitin-proteasome\u2013mediated processes (SCF- and APC/C-dependent catabolic pathways, polyubiquitination) and mitotic spindle assembly, pointing to protein turnover and cell-cycle control. Ribosome biogenesis and growth-related signaling terms further support a theme of coordinated proteostasis with cell-cycle progression, despite some peripheral terms related to nutrient signaling and stress responses. Overall, the functions cohere around protein homeostasis and division machinery.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0031146","count":6},{"id":"GO:0031145","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0000209","count":5},{"id":"GO:0007200","count":5}]},{"hash":"533672768029707773","title":"Eye development and cellular stress responses","description":"The cluster is dominated by terms related to retina development and visual perception, strongly suggesting eye-related function. The other terms point to cellular stress and immune/damage responses (apoptosis, xenobiotic and oxidative stress, LPS, virus), indicating a set of proteins involved in stress signaling within ocular tissues. Some terms like DNA recombination are less directly connected but may reflect shared regulatory processes in these proteins. Overall, a coherent theme around eye development with stress-response pathways fits best.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0070301","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0006310","count":3}]},{"hash":"460171287318325652","title":"Developmental Regulation with Stress Responses","description":"The cluster's GO terms cluster around transcriptional regulation (DNA-templated transcription) and various developmental processes (multicellular organism development, retina development, skeletal system development), combined with stress and immune-related responses (ER-stress\u2013induced intrinsic apoptosis, cellular response to cadmium, defense against Gram-positive bacteria). This suggests proteins involved in developmental gene regulation that also engage cellular stress pathways, rather than a single narrow function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0050830","count":3}]},{"hash":"2087838062607422031","title":"Developmental transcription and chromatin regulation","description":"The cluster shows enrichment for transcription initiation and Notch-regulated transcription, plus multicellular development and endoderm differentiation, with histone H3 acetylation signaling chromatin modification. This points to a set of transcriptional regulators operating during development and chromatin-level control.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0007275","count":2},{"id":"GO:2000584","count":2},{"id":"GO:0006352","count":1},{"id":"GO:0051090","count":1}]},{"hash":"321491164344767079","title":"Larval chitin-based cuticle development","description":"The cluster is characterized by strong enrichment for chitin-based cuticle development and the larval-specific term, suggesting proteins involved in insect cuticle formation during larval development and related morphogenesis; other terms occur at low frequency and do not redefine the main theme.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":4},{"id":"GO:0010171","count":4},{"id":"GO:2000372","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0016567","count":1}]},{"hash":"1594951516914698915","title":"Unknown","description":"The top GO terms are diverse, including neural-related functions (visual perception and memory) alongside broader cellular processes (apoptosis regulation, autophagy, cytokinesis, hypoxia response) and development terms (heart development). There isn\u2019t a single coherent function uniting these terms, so a clear, specific label isn\u2019t supported.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0043950","count":2},{"id":"GO:0016237","count":2},{"id":"GO:0007614","count":2}]},{"hash":"1294421625525363387","title":"Organ and tissue development","description":"Top development-related terms such as multicellular organism development, heart development, angiogenesis, ossification, skin development, and visual perception point to a shared theme of tissue and organ morphogenesis across different systems. While a few terms reflect broader or cross-kingdom signaling, the dominant signal is developmental processes shaping tissues. Therefore, this cluster is best described as Organ and tissue development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":9},{"id":"GO:1903244","count":8},{"id":"GO:0007507","count":7},{"id":"GO:0043931","count":7},{"id":"GO:0071313","count":6}]},{"hash":"1788421028911477638","title":"Unknown","description":"The top GO terms are diverse and non-cohesive, spanning immune cell differentiation (dendritic cells, T cells, germinal center formation) as well as plant tropisms (phototropism, gravitropism), ubiquitination, and cell-cycle regulation, with no clear shared function tying all proteins together.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0043380","count":2},{"id":"GO:0032764","count":2},{"id":"GO:2000176","count":2}]},{"hash":"2130053434232230579","title":"Mitochondrial function and lipid/sterol biosynthesis","description":"The cluster\u2019s top GO terms center on mitochondria, including mitochondrial inheritance, complex IV assembly, and regulation of cytochrome c release, pointing to mitochondrial biogenesis and energy metabolism. There is also a clear lipid/sterol metabolism signal: ergosterol biosynthesis, unsaturated fatty acid biosynthesis, and mannosyl-inositol phosphorylceramide metabolism, which are lipid pathway processes often linked to fungal biology. Some terms like nitric oxide biosynthesis and nitrate assimilation suggest broader metabolic activity, but the dominant pattern ties mitochondrial function to lipid/sterol metabolism. Tissue-specific terms (myelin maintenance, sebaceous gland differentiation) might reflect broader gene functions or annotation noise, but do not override the central theme. Overall, the cluster appears best described by a mitochondrial function plus lipid/sterol biosynthesis theme.","confidence":"Medium","size":13,"edges":13,"triangles":1,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0032443","count":2},{"id":"GO:0006809","count":2}]},{"hash":"331936539772326173","title":"Unknown","description":"The GO terms span a broad and inconsistent set of processes (immune signaling, transcription regulation, morphogenesis in different tissues, cell cycle, metabolism, and signaling responses) with no clear shared function or molecular activity binding the cluster, so there isn\u2019t a coherent label that accurately captures the cluster\u2019s biology.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002774","count":1},{"id":"GO:0000435","count":1},{"id":"GO:0003186","count":1},{"id":"GO:0032298","count":1},{"id":"GO:0045819","count":1}]},{"hash":"821322701522613413","title":"GABAergic Inhibition and Neural Development","description":"The cluster is dominated by GO terms related to gamma-aminobutyric acid signaling and inhibitory synaptic activity (GABA signaling pathway, GABA receptor clustering, inhibitory postsynaptic potential, negative regulation of action potential, negative regulation of chloride transport). Additional terms pertain to neural development and CNS-related structures (optic nerve morphogenesis, inner ear receptor cell development) and a conditioned taste aversion behavior, all consistent with GABAergic regulation in neural circuits. The common thread is GABA-mediated inhibition shaping neural signaling and development, hence this label.","confidence":"High","size":13,"edges":70,"triangles":208,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007214","count":12},{"id":"GO:0001661","count":12},{"id":"GO:2001226","count":11},{"id":"GO:0021631","count":11},{"id":"GO:0060119","count":11}]},{"hash":"369802769108062898","title":"Cell cycle and proliferation signaling","description":"Top GO terms show a cohesive theme around regulation of cell cycle progression and proliferative signaling, including G2/M transition and CDK activity, and pathways tied to growth and regeneration (Wnt signaling, liver regeneration, T cell proliferation). Some terms appear peripheral (e.g., early viral transcription, metabolic transcription regulation, vitamin E response), but the dominant signal points to cell cycle control and proliferation pathways.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000411","count":1},{"id":"GO:0042098","count":1},{"id":"GO:0097421","count":1},{"id":"GO:0045737","count":1},{"id":"GO:0019085","count":1}]},{"hash":"471547781181961943","title":"Olfactory learning and memory regulation","description":"The terms are dominated by neural learning and memory-related processes (olfactory learning, conditioned taste aversion, long-term memory) and regulation of synaptic transmission/plasticity, including glutamatergic pathways, pointing to experience-dependent synaptic changes in sensory systems; a few development terms (lateral line) are present but do not override the central theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008355","count":4},{"id":"GO:0001661","count":4},{"id":"GO:0050806","count":3},{"id":"GO:0048915","count":3},{"id":"GO:0048899","count":3}]},{"hash":"2225114605803351645","title":"Oogenesis and axis specification","description":"The top GO terms cluster around oogenesis-related processes (follicle cell of egg chamber stalk formation; oocyte axis specification) and include Wnt signaling and microtubule cytoskeleton organization, suggesting a functional group governing egg chamber development and polarity establishment. While a few terms reference transcription regulation and axon extension, the dominant theme is oocyte development and axis formation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0030713","count":1},{"id":"GO:0043001","count":1},{"id":"GO:0007026","count":1}]},{"hash":"2199585284607768874","title":"Innate Immune Activation and Phagocytosis Signaling","description":"The top GO terms cluster around innate immune receptor signaling and phagocytic processes: stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, phagocytosis recognition, basophil activation, NK cell chemotaxis regulation, and platelet activation. These indicate activation of innate immune cells and phagocytosis pathways. A few terms pertain to development or tissue remodeling, but they are less central to the core theme. Overall, the cluster appears to reflect innate immune activation and phagocytic signaling.","confidence":"High","size":13,"edges":37,"triangles":42,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":13},{"id":"GO:0090403","count":13},{"id":"GO:0002223","count":13},{"id":"GO:0006910","count":13},{"id":"GO:0038094","count":13}]},{"hash":"1150168162602575703","title":"Unknown","description":"The GO terms cover a broad mix: sensory perception (pain, vision), various developmental processes (heart, multicellular development), metabolism/thermogenesis, temperature response, calcium signaling, potassium transport, and cell proliferation. This lack of a single cohesive function makes a specific label untenable.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0071502","count":4}]},{"hash":"557049244329928288","title":"Unknown","description":"The top GO terms span diverse processes (sensory and chemical responses, neuroendocrine secretion, plant hormone regulation, development, and inflammation) across potentially different species, with no clear shared function or connectivity, so there is no coherent theme linking these proteins.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071313","count":3},{"id":"GO:0030317","count":3},{"id":"GO:0080141","count":3},{"id":"GO:0030103","count":3},{"id":"GO:0050968","count":3}]},{"hash":"576811699809540660","title":"Ubiquitin-Dependent Cell Cycle Regulation","description":"The top GO terms point to ubiquitin-mediated proteolysis, including ubiquitin-dependent protein catabolic process, K11-linked ubiquitination, and APC-dependent proteolysis, as well as mitotic cell cycle and cell division. This suggests a core function in controlling progression through the cell cycle via ubiquitin-proteasome\u2013mediated protein turnover, with some ancillary associations (cadmium response, neuronal plasticity) likely incidental. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000312","count":6},{"id":"GO:0060707","count":4},{"id":"GO:0042787","count":4},{"id":"GO:2001162","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1330840479701452488","title":"Chemokine-driven inflammatory response","description":"This cluster is best characterized by immune-related terms: production of molecular mediators in the inflammatory response and positive regulation of chemokine production, pointing to inflammatory signaling. The presence of chitin catabolic and carbohydrate metabolic processes suggests some annotation noise or broader metabolic roles, but the strongest consistent theme among the top terms is inflammation/chemokine signaling. Edges are absent, indicating a loose functional grouping, but the immune-related terms provide a meaningful core theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0005975","count":2},{"id":"GO:1903586","count":1}]},{"hash":"1190009940270885027","title":"Immune and Developmental Signaling","description":"Top GO terms indicate involvement in adaptive immune response and T cell regulation alongside developmental and vascular processes such as organ induction, angiogenesis, paraxial mesoderm development, and smooth muscle proliferation, with ERK signaling highlighted. The convergence of immune and mesoderm/vasculature development themes suggests a cluster of proteins that participate in immune signaling intersecting with developmental pathways, though the lack of interactions implies heterogeneity. Confidence reflects this partial alignment: not all terms fit a single cohesive function, but the dominant themes are clear.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0001759","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0048339","count":2}]},{"hash":"1604072883066982294","title":"Adaptive immune differentiation regulation","description":"The top GO terms cluster around regulation and promotion of adaptive immune cell differentiation, including dendritic cell differentiation, pro-T cell differentiation, memory T cell differentiation, and germinal center formation, indicating a cohesive theme of controlling immune cell development and function. Some terms are plant-specific (phototropism, gravitropism) or obsolete neuronal/receptor regulation terms, suggesting possible misannotations or noise in the dataset.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":8},{"id":"GO:1900477","count":7},{"id":"GO:2001200","count":7},{"id":"GO:0043380","count":7},{"id":"GO:0032764","count":7}]},{"hash":"1114277120913403125","title":"GPCR endocytosis and signaling regulation","description":"The cluster shows strong enrichment for GO terms related to G protein-coupled receptor internalization and clathrin-dependent endocytosis, indicating a shared function in receptor trafficking. Additional terms on androgen receptor signaling regulation and stem cell differentiation suggest that trafficking of receptors may influence signaling pathways and differentiation. Therefore the label captures both the trafficking mechanism and its link to signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060765","count":2},{"id":"GO:0048863","count":2},{"id":"GO:0002031","count":2},{"id":"GO:0072583","count":2},{"id":"GO:0030208","count":1}]},{"hash":"1256185078895849905","title":"Chromatin methylation and epigenetic regulation","description":"The Top Terms are dominated by methylation-related processes (rRNA methylation, peptidyl-arginine/lysine/glutamine methylation) and chromatin-associated functions (rDNA heterochromatin formation, histone methylation), suggesting a cohesive role in epigenetic regulation and chromatin structure. Peripheral terms like cobalamin biosynthesis and tellurium ion response may be incidental noise relative to the core methylation/epigenetic theme.","confidence":"Medium","size":12,"edges":54,"triangles":136,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0031167","count":2},{"id":"GO:0019919","count":2},{"id":"GO:0090398","count":2},{"id":"GO:0018364","count":2}]},{"hash":"73595541629555114","title":"Neural and sensory organ development (vertebrates)","description":"The top GO terms are dominated by vertebrate neural and sensory structures (midbrain, forebrain, inner ear, peripheral nervous system, pituitary gland) plus early embryonic development (primitive streak, multicellular organism development). The presence of negative regulation of transcription by RNA polymerase II suggests transcriptional control important for these developmental programs, supporting a theme of embryonic neural/sensory organ formation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0021983","count":5},{"id":"GO:0048935","count":4},{"id":"GO:0090009","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1067364458854171897","title":"Biomineralization and Neural Crest Development","description":"The cluster centers on biomineral tissue formation (amelogenesis) and neural crest\u2013driven development, with terms such as biomineral tissue development, amelogenesis, ventral trunk neural crest cell migration, and sympathetic neuron projection guidance, suggesting a shared theme of mineralized tissue formation linked to neural crest derivatives; immune-related terms appear ancillary.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0097186","count":2},{"id":"GO:0036486","count":2}]},{"hash":"864392236819373293","title":"Developmental patterning and organogenesis","description":"These proteins are associated with a broad set of embryonic development processes, including midbrain development, left-right patterning, and morphogenesis of cartilage, placenta, heart endocardial cushions, and endocrine organs. The common thread is developmental patterning and organogenesis rather than a single molecular function, justifying a label focused on developmental processes.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060707","count":5}]},{"hash":"431251747681369329","title":"Neural crest development and axon guidance","description":"Based on the GO terms, this cluster centers on neural crest\u2013driven development and neural connectivity: neural crest cell migration (autonomic NS development and ventral trunk), facioacoustic ganglion development, vestibulocochlear nerve organization, and axon guidance/extension regulation. Wnt signaling supports neural crest induction and guidance, while vitamin D response and endosome localization appear ancillary. Overall, the proteins likely function together in neural crest\u2013driven neurodevelopment and neural circuit formation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0060672","count":3},{"id":"GO:1901166","count":3},{"id":"GO:1903375","count":3}]},{"hash":"1139277105589101829","title":"Neuronal Synaptic Transmission and Plasticity","description":"Based on the GO terms, the cluster centers on ion transport across membranes (sodium and potassium), which underlies action potential and neurotransmitter release, and on regulation and plasticity of synapses (short-term and long-term, including glutamatergic signaling). Some terms relate to neural development and behavior, such as lateral line development and social behavior, suggesting these proteins participate in neural circuits that shape behavior. Overall, the cluster represents components involved in neuronal signaling and synaptic plasticity modulation.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0035176","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0050806","count":2}]},{"hash":"1313597734076468728","title":"Unknown","description":"The terms span proton transport, centrosome/cytoskeleton localization, centrosome cohesion, dorsal-identity development, CNS vasculogenesis, chromatin remodeling, ER calcium regulation, and vacuole junctions, which do not converge on a single clear function or pathway. Therefore a specific, representative label is not evident from these GO terms.","confidence":"","size":12,"edges":62,"triangles":184,"max_degree":11,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":7},{"id":"GO:0072699","count":6},{"id":"GO:0030997","count":6},{"id":"GO:0061380","count":6},{"id":"GO:0071562","count":6}]},{"hash":"2021306636462685158","title":"Vesicle trafficking and cell cycle regulators","description":"Top terms span vesicle transport and organelle assembly (cilium assembly, endosome size, regulation of protein secretion, presynapse assembly) as well as mitosis-related processes (mitotic cell cycle, chromosome passenger complex localization to kinetochore), with additional yeast-associated signals (budding, pheromone response) and a tRNA modification term. Together these suggest a cluster of proteins involved in intracellular transport and coordination with cell division, rather than a single specialized function. ","confidence":"Medium","size":12,"edges":57,"triangles":151,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060271","count":12},{"id":"GO:0050709","count":12},{"id":"GO:0051036","count":12},{"id":"GO:0006547","count":12},{"id":"GO:1905608","count":12}]},{"hash":"508513355848298360","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":38,"triangles":53,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0022013","count":4},{"id":"GO:0044830","count":4},{"id":"GO:0048024","count":4},{"id":"GO:0016120","count":4}]},{"hash":"2043075875608069573","title":"Diverse membrane transporters for nutrients and ions","description":"The cluster is characterized by numerous transmembrane transport GO terms across substrates such as nitrate/nitrite, galactose, vitamins, sugars, xenobiotics, sodium ions, and fucose, with an additional note on neurotransmitter loading into synaptic vesicles and larval cuticle development. This pattern points to a cohesive set of membrane transport proteins handling diverse substrates, spanning nutrient uptake, ion balance, and xenobiotic handling, potentially in insect development and neural contexts.","confidence":"Medium","size":12,"edges":18,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0015757","count":1},{"id":"GO:0015706","count":1}]},{"hash":"170838107531890657","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0098789","count":2},{"id":"GO:0006398","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0000184","count":1}]},{"hash":"775589464851335069","title":"Cardiac Development and Ventricular Morphogenesis","description":"The top GO terms are dominated by heart-related processes, including heart development and ventricular cardiac muscle tissue morphogenesis, indicating the cluster is enriched for cardiac development. Supporting terms like cellular response to hypoxia and regulation of membrane tubulation suggest related cellular remodeling in cardiac tissue, while a few others (e.g., cytokinesis regulation, chromatin binding) may reflect broader cellular control. Overall, the cardiac development signal is the most representative theme for this cluster.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043950","count":3},{"id":"GO:0016237","count":3},{"id":"GO:0032465","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1147222583042468286","title":"Developmental cell adhesion and mitotic spindle machinery","description":"The cluster includes GO terms for cell adhesion, spindle assembly, centrosome cycle, and animal organ development, with additional signals related to apoptosis and drug response. Though several histone modification terms are obsolete, the dominant themes point to roles in cell\u2013cell adhesion during development and in the mitotic/spindle machinery governing cell division, suggesting a cohesive function in developmental tissue organization. ","confidence":"Medium","size":12,"edges":14,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:1901726","count":1},{"id":"GO:0051225","count":1},{"id":"GO:0044648","count":1},{"id":"GO:1901674","count":1}]},{"hash":"1016735048634265139","title":"Innate Immune Activation and Inflammation","description":"This cluster centers on innate immune signaling and inflammatory responses, with terms for TLR2 and TLR3 signaling, inflammatory response, positive regulation of chemokine and IL-8 production, and TNF production, plus NLRP3 inflammasome assembly and MHC class I biosynthesis. The inclusion of cell migration and lamellipodium organization further supports contexts of immune cell movement and trafficking during inflammation. Overall, the proteins appear to function in innate immune activation and inflammatory signaling.","confidence":"High","size":12,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0032760","count":1},{"id":"GO:0034134","count":1},{"id":"GO:0006954","count":1},{"id":"GO:0032722","count":1},{"id":"GO:0045345","count":1}]},{"hash":"1389624104453332398","title":"Insect cuticle development and morphogenesis","description":"The top GO terms center on larval and chitin-based cuticle development and body morphogenesis, with supporting chitin catabolic and carbohydrate metabolic processes, pointing to cuticle formation and remodeling during development. Some chromatin and inflammatory-related terms appear but are likely incidental or reflects broader cellular regulation. Overall, the cluster seems to group proteins involved in insect cuticle construction and morphogenesis.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0010171","count":1},{"id":"GO:0006334","count":1},{"id":"GO:0030261","count":1}]},{"hash":"1320627671429816175","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":63,"triangles":191,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0042273","count":6},{"id":"GO:0071049","count":5},{"id":"GO:1900050","count":5},{"id":"GO:1902775","count":5},{"id":"GO:1990416","count":5}]},{"hash":"2296132123860414154","title":"Neural development and neurotransmission","description":"GO terms point to neural development and signaling, including innervation, inner ear and visual system development, dopamine secretion, synaptic potentiation, locomotory behavior, and ion transport supporting neuronal activity. Together these suggest proteins involved in neural development and neurotransmission across sensory and motor pathways.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":10},{"id":"GO:0060119","count":9},{"id":"GO:0060384","count":9},{"id":"GO:1905920","count":9},{"id":"GO:0035725","count":9}]},{"hash":"518047688931317763","title":"Embryogenesis and lymphoid organ development","description":"This cluster's top GO terms cluster around embryonic patterning and lymphoid tissue formation (mesendoderm development, lymph node development, T cell homeostasis, chorio-allantoic fusion, pancreatic cell development), suggesting a shared role in organogenesis and immune system development; the few metabolism terms likely reflect incidental annotations.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048382","count":2},{"id":"GO:0048535","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0060710","count":2},{"id":"GO:0003323","count":2}]},{"hash":"259930328018995173","title":"Skin and cuticle development","description":"The top GO terms point to epidermal/outer barrier formation (larval cuticle development, skin development) with supporting signals of broader tissue morphogenesis (endodermal differentiation, cartilage and smooth muscle morphogenesis). A couple of terms (RNA Pol III transcription and interferon-beta production) appear incidental to the main theme. Overall, the cluster seems focused on developmental differentiation, especially epidermal/cuticle formation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0006359","count":1},{"id":"GO:0006384","count":1},{"id":"GO:0042797","count":1}]},{"hash":"1800031108083244185","title":"Glutamatergic Synapse Modulation","description":"The cluster is dominated by GO terms tied to glutamatergic synaptic transmission, prepulse inhibition, and regulation of synaptic signaling, with related GPCR signaling and intracellular pathways, plus a few species-specific developmental terms. This points to a functional group centered on glutamatergic neurotransmission and its modulation rather than a broader or unrelated theme. ","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060134","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0032024","count":2},{"id":"GO:0050806","count":1}]},{"hash":"198158212609890497","title":"Neural development and synaptic connectivity","description":"The cluster\u2019s top GO terms converge on nervous system development and neuronal connectivity, including peripheral nervous system development, nervous system development, transmission of nerve impulse, retina morphogenesis, myelination, and synapse organization. Additional terms point to neuronal signaling and wiring processes such as chemorepulsion in interneuron migration and dendrite self-avoidance, suggesting these proteins coordinate the growth, patterning, and functional wiring of neural circuits. Overall, the set reflects a cohesive role in neural development and synaptic organization.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007422","count":11},{"id":"GO:0019226","count":11},{"id":"GO:0060060","count":11},{"id":"GO:0060168","count":11},{"id":"GO:0042552","count":11}]},{"hash":"1479007569718655772","title":"Valvulogenesis and cardiovascular development","description":"The cluster shows enrichment for heart-specific processes such as mitral valve formation, endocardial cushion migration, and cell adhesion, plus angiogenesis and vascular development, pointing to valvulogenesis and cardiovascular morphogenesis as the core theme. Some terms like ossification and neuronal stem cell maintenance are present but seem less central to the dominant cardiovascular signal.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090197","count":5},{"id":"GO:0007156","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0045766","count":4}]},{"hash":"320764909531138713","title":"Retroviral DNA Integration and Latency","description":"This cluster is dominated by GO terms tied to retroviral life cycle processes: DNA replication, DNA integration, RNA-templated DNA biosynthesis, and establishment of proviral latency, along with viral entry into the host nucleus and DNA recombination. The combination suggests proteins involved in retroviral replication and integration, as well as host interactions that enable proviral latency and potentially counter host RNA silencing. A few terms, such as symbiont entry and plant cell wall biosynthesis, may reflect broader host\u2013microbe interaction contexts or annotation noise, but the core signal points to retroviral DNA handling and latency.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2}]},{"hash":"509447651082452274","title":"Unknown","description":"The top GO terms cover highly diverse processes (angiogenesis, cardiac signaling, cell cycle, hormone secretion, neural differentiation, apoptosis, DNA-related modification, pain sensing, immune regulation, and telomere binding) with no clear shared function, and there are no network edges to tie them together, so a cohesive, specific label cannot be derived.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":3},{"id":"GO:0086070","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0030103","count":3},{"id":"GO:0021707","count":3}]},{"hash":"2151294532033064526","title":"Unknown","description":"The top GO terms span diverse and largely unrelated processes (angiogenesis, cardiac signaling, cell cycle, vasopressin secretion, neuronal differentiation, hepatocyte apoptosis, protein ADP-ribosylation, pain perception, IL-12 regulation, and telomere binding regulation) with no single dominant function or shared pathway, and the cluster has no edges, suggesting the proteins do not coalesce around a cohesive biological role. Therefore, a specific, representative label cannot be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":3},{"id":"GO:0086070","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0030103","count":3},{"id":"GO:0021707","count":3}]},{"hash":"210552743824509630","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903883","count":3},{"id":"GO:2000653","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0061158","count":3},{"id":"GO:0043123","count":3}]},{"hash":"2249758803949731720","title":"Unknown","description":"The top GO terms span heart and eye development, nuclear receptor signaling, transcription, and mitotic processes, with no single cohesive function tying these terms together. This cluster appears to mix developmental signaling and transcriptional regulation with cell division, making a focused, high-level label inappropriate. ","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055012","count":1},{"id":"GO:0007507","count":1},{"id":"GO:0051987","count":1},{"id":"GO:1990758","count":1},{"id":"GO:0031116","count":1}]},{"hash":"116237942399487091","title":"Innate Immune Signaling and Phagocytic Activation","description":"This cluster is dominated by terms tied to innate immune cell signaling and effector functions, including stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, phagocytosis recognition, basophil activation, and NK cell chemotaxis regulation, indicating coordinated innate immune activation and phagocytic responses. Some other terms about development and morphogenesis may reflect pleiotropic roles or shared signaling contexts but do not define the main theme. Overall, the proteins appear linked by immune recognition and effector signaling pathways.","confidence":"Medium","size":12,"edges":34,"triangles":42,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":6},{"id":"GO:0036303","count":4},{"id":"GO:0090403","count":4},{"id":"GO:0006910","count":4},{"id":"GO:0038094","count":4}]},{"hash":"1880991214990352371","title":"Excitatory synaptic transmission and plasticity","description":"Based on GO terms dominated by excitatory neuronal processes (sodium/potassium ion transport, excitatory postsynaptic potential, long-term potentiation regulation, startle response, conditioned taste aversion) with complementary terms related to glutamate transport and vesicle trafficking, this cluster most coherently reflects excitatory synaptic signaling and plasticity in neurons. Some terms about mitochondrial stress and ER-Golgi transport are broader cellular processes but do not override the prevailing neuronal excitability signal.","confidence":"Medium","size":12,"edges":15,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":2},{"id":"GO:0035725","count":2},{"id":"GO:1900273","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0060079","count":2}]},{"hash":"1086494876183766050","title":"Transmembrane ion transport and pH regulation","description":"The cluster centers on transport of multiple ions (nitrate, sodium, potassium, protons, and iron-related regulation) and related osmotic/pH homeostasis processes (water transport, response to acidic pH, cell volume regulation), suggesting a cohesive role in membrane ion movement and pH/osmotic balance.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0034756","count":1},{"id":"GO:1903959","count":1}]},{"hash":"829456017568384866","title":"Bacterial cell wall biosynthesis and metabolism","description":"These proteins show GO terms tied to cell wall processes (teichoic acid D-alanylation, cell wall organization) and several bacterial metabolic pathways (menaquinone biosynthesis, pyruvate fermentation to acetate, very long-chain fatty acid metabolism, nonribosomal peptide biosynthesis activation). The mix suggests a cluster centered on cell-wall\u2013associated functions plus overall bacterial metabolism, though the set is diverse. Confidence: Medium","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070400","count":1},{"id":"GO:0009698","count":1},{"id":"GO:0008206","count":1},{"id":"GO:0009234","count":1},{"id":"GO:0090410","count":1}]},{"hash":"1553944760749085996","title":"Chromatin remodeling and histone modification","description":"The top GO terms cluster around chromatin dynamics and epigenetic regulation, including nucleosome disassembly, chromatin remodeling, histone acetylation regulation, and histone methylation (H3-K36). Although there are a couple of metabolic terms present, the dominant theme is chromatin remodeling and histone modification, suggesting a group of proteins involved in epigenetic control of gene expression.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":2},{"id":"GO:0031496","count":2},{"id":"GO:0035066","count":2},{"id":"GO:0006337","count":2},{"id":"GO:0090043","count":2}]},{"hash":"689790847331909142","title":"Unknown","description":"This cluster's top GO terms are highly heterogeneous, including immune cell differentiation (dendritic cell differentiation, T cell differentiation, germinal center formation), ubiquitination, and plant tropisms (phototropism, gravitropism). There is no single coherent biological process linking these terms, and the graph has no edges, so a meaningful functional label cannot be assigned beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0043380","count":2},{"id":"GO:0032764","count":2},{"id":"GO:2000176","count":2}]},{"hash":"925850442658117093","title":"Developmental patterning and organogenesis","description":"These proteins map to diverse developmental processes: somitogenesis, floor plate and cranial skeletal development, lung vasculature development, amacrine cell differentiation, apical/basal polarity establishment, and broader transcriptional regulation. The common thread is embryonic development and tissue patterning across multiple tissues, suggesting a coordinated developmental program rather than a single pathway, with some ancillary signaling components such as insulin signaling likely playing supportive roles.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001756","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0035089","count":2},{"id":"GO:0033504","count":2},{"id":"GO:0008286","count":2}]},{"hash":"504491538194688169","title":"Organogenesis and developmental signaling","description":"The terms point to regulation of development and organ formation across multiple tissues (bone, heart, pancreas, hair, plant stomata, aorta) and include Notch signaling and other pathway-related processes, suggesting a unifying theme of developmental differentiation and organogenesis rather than a single biochemical function.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":11},{"id":"GO:0060766","count":11},{"id":"GO:0010374","count":10},{"id":"GO:0032933","count":10},{"id":"GO:0035910","count":10}]},{"hash":"685931708542259655","title":"Vertebrate organogenesis and neural development","description":"The terms point to vertebrate embryonic development across neural and organ systems\u2014neural development (neuron apoptosis regulation, forebrain proliferation, glial differentiation, brain segmentation, neurohypophysis development) alongside organogenesis (heart development, cochlea morphogenesis, nephric duct elongation, chondrocyte differentiation). This indicates a broad developmental program affecting multiple tissues rather than a single, cohesive pathway, with neural differentiation and general organ morphogenesis as common themes.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":11},{"id":"GO:0021985","count":11},{"id":"GO:0021846","count":11},{"id":"GO:0010001","count":11},{"id":"GO:0035284","count":11}]},{"hash":"1131380562304765053","title":"Sensory Neural Development and Dopaminergic Signaling","description":"The top terms converge on development and function of sensory neural systems: retina development, visual perception, cochlea morphogenesis, and midbrain dopaminergic neuron differentiation, with supporting regulation of ERK signaling and dopamine uptake, plus neuroprotection. A heart development term is present but does not override the dominant sensory-neural theme.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0060041","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0090103","count":3}]},{"hash":"630826283960547249","title":"Quinone biosynthesis and related metabolism","description":"This cluster shows strong enrichment for quinone biosynthesis (menaquinone and phylloquinone) along with fatty acid beta-oxidation and various amino acid catabolic pathways, suggesting a core theme of quinone-related metabolism and energy-yielding processes. Translation-related terms are present but less prominent, likely background noise.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0010124","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0006574","count":2}]},{"hash":"1454712887206161152","title":"Reproductive Gland Development and Transcriptional Regulation","description":"The top GO terms cluster around development of reproductive and glandular tissues (mammary gland alveolus, Leydig cells, male gonad, prostate glandular structures), suggesting a theme of gland/sex organ development. The presence of DNA-templated transcription and regulation of cell cycle implies transcriptional control during these developmental processes. Some terms are less directly related (macrophage activation regulation, galactose-regulated transcription), but they do not override the core pattern. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0060749","count":3},{"id":"GO:0033327","count":3},{"id":"GO:0071157","count":3},{"id":"GO:0051301","count":3}]},{"hash":"33350900390630637","title":"Neural development and motor neuron differentiation","description":"The cluster\u2019s top GO terms consistently point to neural development and neuron subtype specification (spinal cord motor neuron cell fate specification, medial motor column neuron differentiation, and midbrain dopaminergic neuron differentiation). There are a few broader developmental terms (ectoderm formation, uterine epithelium development) and some obsolete ones, but the dominant signal is neural differentiation and motor neuron specification, justifying a focused label.","confidence":"High","size":11,"edges":50,"triangles":122,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060396","count":7},{"id":"GO:0010735","count":7},{"id":"GO:0001705","count":7},{"id":"GO:0030579","count":7},{"id":"GO:0021526","count":7}]},{"hash":"1301265421167298505","title":"Unknown","description":"The terms are highly diverse, ranging from sensory perception and signaling to transcription and cytolysis, with little apparent overlap to define a single cohesive function. The absence of edges or interactions reinforces the lack of a unifying theme, so a specific functional label cannot be confidently assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050975","count":2},{"id":"GO:0016998","count":2},{"id":"GO:0090240","count":1},{"id":"GO:0090327","count":1},{"id":"GO:0060189","count":1}]},{"hash":"521671737472520786","title":"Developmental morphogenesis","description":"The top GO terms cluster around tissue and organ formation, including hair follicle morphogenesis, cartilage morphogenesis, roof of mouth development, mesoderm development, left-right patterning, placenta-related differentiation, and EMT in endocardial cushion formation, along with broader endocrine system and embryonic development terms. This suggests the proteins participate in developmental morphogenesis across multiple tissues, not limited to one organ, justifying the label Developmental morphogenesis.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":2},{"id":"GO:0010957","count":2},{"id":"GO:0007498","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0035270","count":2}]},{"hash":"298662718620407034","title":"Mitotic progression and transcription control","description":"The cluster is enriched for processes tied to cell cycle control and transcription: DNA-templated transcription, mRNA capping, G2/M transition, kinetochore localization, and mitotic spindle pole separation, as well as CDK activity regulation. A few development terms appear, but the dominant signal points to mitotic regulation and transcriptional machinery.","confidence":"High","size":11,"edges":41,"triangles":64,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0060749","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0033327","count":3},{"id":"GO:0034501","count":3}]},{"hash":"1494552980310766239","title":"Cranial neural crest migration and ganglion development","description":"This cluster is dominated by GO terms for cranial structure formation and neural crest cell migration (trigeminal and facioacoustic ganglion development, neural crest autonomic development, vestibulocochlear nerve organization) along with neuronal maturation and synaptic regulation (synapse maturation, axon guidance, plasticity). The common theme is development of cranial nerves and neural crest\u2013derived neurons, consistent with a shared function in cranial neural crest\u2013driven neurodevelopment.","confidence":"High","size":11,"edges":14,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":6},{"id":"GO:0061551","count":6},{"id":"GO:0060074","count":5},{"id":"GO:1901166","count":5},{"id":"GO:1903375","count":5}]},{"hash":"1514224232334145116","title":"RNA Splicing and Transcription Regulation","description":"The cluster is dominated by RNA processing and transcriptional control terms, including RNA splicing, spliceosome regulation, and negative regulation of transcription by RNA Pol II, with a link to cell-cycle transition (G0 to G1). A circadian clock term (temperature compensation) hints at temporal regulation, though a few terms (deubiquitination, gluconeogenesis, atrial septum development) appear as less coherent outliers. Overall, the core theme is RNA processing and transcriptional regulation linked to cell cycle and circadian timing.","confidence":"Medium","size":11,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1990168","count":1},{"id":"GO:0006977","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0090526","count":1},{"id":"GO:0008380","count":1}]},{"hash":"2099353990955777050","title":"Spliceosome-driven RNA processing and translation regulation","description":"The top GO terms point to mRNA splicing and general RNA processing via the spliceosome, alongside regulation of translation initiation and miRNA-mediated silencing. This suggests a cluster centered on post-transcriptional gene expression control, including RNA maturation and translation regulation.","confidence":"High","size":11,"edges":40,"triangles":71,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1903586","count":11},{"id":"GO:0035278","count":11},{"id":"GO:0006378","count":11},{"id":"GO:1900363","count":11},{"id":"GO:1905663","count":11}]},{"hash":"1696510662853774812","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by the GO term GO:0008363, \u201clarval chitin-based cuticle development,\u201d with 11 proteins, indicating a cohesive role in larval exoskeleton formation and remodeling via chitin-based cuticle processes.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11}]},{"hash":"1050896282907201489","title":"Viral Entry, Genome Integration, and Proviral Latency","description":"The top GO terms cluster around virus- and symbiont-associated processes: penetration into the host nucleus, establishment of integrated provirus latency, and DNA integration, with supporting signals of DNA transposition and host apoptosis activation. These collectively point to a theme of viral entry and genome integration with proviral latency and host genome interactions, rather than a single canonical cellular process.","confidence":"Medium","size":11,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":1},{"id":"GO:0001576","count":1},{"id":"GO:0000122","count":1},{"id":"GO:1900112","count":1},{"id":"GO:0015074","count":1}]},{"hash":"60693819967683939","title":"Developmental morphogenesis across tissues","description":"This cluster centers on tissue and organ development across multiple lineages (body morphogenesis, heart/endocardial cushion formation, lung branching morphogenesis, neuronal axon guidance, vascular lumen formation) and includes adhesion processes; together, thego terms suggest a general developmental program rather than a single pathway, with pigmentation-related terms adding to the developmental theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":4},{"id":"GO:0010171","count":4},{"id":"GO:0036515","count":1},{"id":"GO:0003273","count":1},{"id":"GO:0032773","count":1}]},{"hash":"986255071978427648","title":"Unknown","description":"No GO terms are provided for this cluster (Top Terms section is empty). With only 2 edges and a max degree of 2 among 11 proteins, there isn\u2019t enough functional signal to deduce a common theme or process. Therefore, the label is Unknown and caution is warranted until more annotations are available.","confidence":"","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"1079989269285518867","title":"Proteolysis Regulation and Proteostasis","description":"The terms cluster around control of proteolysis and protein degradation (negative regulation of proteolysis; regulation of peptidase activity; ubiquitin-dependent ERAD), pointing to proteostasis as a core function. Additional terms reflect membrane- and adhesion-related contexts (inner mitochondrial membrane organization; lipid localization; extracellular matrix disassembly; cadherin-mediated adhesion) that often intersect with proteolytic remodeling. Together, they suggest a cohesive cluster centered on proteolysis regulation and protein quality control, with membrane and ECM remodeling as related aspects.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0045861","count":8},{"id":"GO:0032933","count":8},{"id":"GO:0007007","count":8},{"id":"GO:0052547","count":8},{"id":"GO:2000049","count":8}]},{"hash":"1754832728939550358","title":"Actin-driven development and synaptic morphogenesis","description":"These proteins predominantly relate to actin cytoskeleton dynamics\u2014Arp2/3-mediated actin nucleation, Rac signaling, lamellipodium and spine morphogenesis, and actin filament capping\u2014alongside developmental processes like somitogenesis and neural synapse maturation. The convergence on cytoskeletal remodeling as a driver of both developmental morphogenesis and neuronal connectivity supports a coherent theme of actin-driven morphogenesis across lineages.","confidence":"High","size":11,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0035855","count":3},{"id":"GO:1900273","count":2},{"id":"GO:0001756","count":2},{"id":"GO:2000601","count":2}]},{"hash":"1802180805719191435","title":"Unknown","description":"The top terms span RNA processing (spliceosome assembly, rRNA processing, pre-mRNA cleavage), ciliary organization (cilia and photoreceptor outer segment), and stress/immune responses (dsRNA response, interferon-alpha, unfolded protein), showing no single cohesive function for all proteins. This diversity makes a confident, concise label difficult.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000354","count":1},{"id":"GO:0071360","count":1},{"id":"GO:0007091","count":1},{"id":"GO:0000464","count":1},{"id":"GO:1903220","count":1}]},{"hash":"19928956029382748","title":"Translation and ribosome dynamics","description":"This cluster is dominated by translation-related terms: maintenance of translational fidelity, cytoplasmic translational termination, translational termination, and ribosome disassembly, along with mRNA decay pathways. These point to a common theme of translation regulation and ribosome turnover, with only weaker ties to stress responses and neural lineages. ","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990145","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0002244","count":1},{"id":"GO:0002184","count":1},{"id":"GO:0035690","count":1}]},{"hash":"523500383081836006","title":"Adrenergic and Dopaminergic GPCR Signaling","description":"The cluster is enriched for GPCR signaling terms centered on adrenergic and dopaminergic pathways, including adenylate cyclase activation and cAMP signaling, norepinephrine-epinephrine\u2013mediated vascular effects, and dopamine metabolism. The presence of inflammatory response, dendritic cell differentiation, and heart development terms suggests this module links GPCR signaling to immune and cardiovascular processes, making adrenergic/dopaminergic signaling the core theme.","confidence":"High","size":11,"edges":50,"triangles":126,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":11},{"id":"GO:0001994","count":11},{"id":"GO:0051482","count":11},{"id":"GO:0006954","count":11},{"id":"GO:0071880","count":11}]},{"hash":"500417922673342133","title":"Morphogenesis and Cytoskeletal Dynamics","description":"GO terms point to developmentally driven morphogenesis across organs (kidney development; trabecula morphogenesis; dendritic spine morphogenesis) and to cytoskeletal dynamics (filopodium assembly; mitotic spindle assembly; negative regulation of cell migration in sprouting angiogenesis). Although spanning several tissues, the common theme is morphogenesis guided by cytoskeletal remodeling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0043524","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0031384","count":1}]},{"hash":"2273837451410909673","title":"Innate immune receptor signaling and phagocytosis","description":"Top terms indicate innate immune sensing and effector functions (C-type lectin and Fc-gamma receptor signaling, phagocytosis recognition, basophil activation, NK regulation, platelet activation), with a few developmental terms as potential pleiotropy. The core theme is immune recognition and phagocytic/antigen-handling pathways.","confidence":"High","size":11,"edges":20,"triangles":23,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":7},{"id":"GO:0090403","count":7},{"id":"GO:0002223","count":7},{"id":"GO:0006910","count":7},{"id":"GO:0038094","count":7}]},{"hash":"1529730330864032577","title":"Exocytosis and Exocyst-Mediated Vesicle Tethering","description":"GO terms cluster around exocytosis, exocyst assembly/localization, vesicle tethering, and Golgi-to-plasma membrane transport, with Rho signaling linking cytoskeletal control of trafficking, pointing to an exocytosis/vesicle-trafficking function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006887","count":3},{"id":"GO:0001927","count":2},{"id":"GO:0007266","count":2},{"id":"GO:0051601","count":2},{"id":"GO:0090522","count":2}]},{"hash":"1015617341061213325","title":"Hormone and stress response with DNA repair","description":"This cluster is driven by GO terms for responses to estradiol and ethanol, together with regulation of the cell cycle and nucleotide-excision repair, plus oxidative stress-induced senescence. These points converge on cellular stress responses and DNA repair pathways, suggesting a cohesive theme around how cells cope with hormonal/stress signals and DNA damage. While immune signaling and development-related terms (phagocytosis, Fc receptor signaling, lymph vessel morphogenesis, cartilage condensation) are also present, the core appears to be stress response coupled with DNA repair processes.","confidence":"Medium","size":11,"edges":18,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032355","count":4},{"id":"GO:0051726","count":4},{"id":"GO:0045471","count":4},{"id":"GO:0006289","count":4},{"id":"GO:0036303","count":3}]},{"hash":"595900229285054686","title":"Amino acid and small-molecule metabolism","description":"This cluster centers on metabolism of amino acids (lysine, proline), neurotransmitter/amine breakdown (GABA, putrescine), and other small-molecule pathways (carnitine, bile acids, menaquinone), with an added regulatory cue (response to cAMP) and a gut-related development term (midgut development). The common theme is broad, small-molecule metabolism with potential gut-context activity, though the midgut term adds some developmental complexity.","confidence":"Medium","size":11,"edges":29,"triangles":32,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0009437","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0009450","count":2},{"id":"GO:0051591","count":2},{"id":"GO:0055129","count":2}]},{"hash":"45306018917738538","title":"Integrated metabolic and signaling response cluster","description":"This cluster shows both metabolic processes (fatty acid biosynthesis; GTP biosynthesis; transsulfuration; homocysteine catabolic; glycine betaine transport; cysteine biosynthesis) and signaling/stress-related responses (cellular response to interleukin-4; negative regulation of TGF-beta signaling; cellular response to glucose starvation; regulation of mitotic transition). The combination suggests proteins that link metabolism with signaling and stress responses rather than a single pathway.","confidence":"Medium","size":11,"edges":34,"triangles":48,"max_degree":10,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006633","count":6},{"id":"GO:0030512","count":3},{"id":"GO:0071353","count":3},{"id":"GO:0006183","count":3},{"id":"GO:0019346","count":3}]},{"hash":"454355340287592915","title":"Unknown","description":"The top GO terms span angiogenesis, cardiac signaling, cell cycle, hormone secretion, neuronal differentiation, apoptosis, protein modification, pain perception, immune regulation, and telomere regulation, with no single shared function linking all proteins. Because the cluster lacks a cohesive biological theme, I cannot assign a confident, specific label beyond Unknown.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":7},{"id":"GO:0086070","count":7},{"id":"GO:0007049","count":7},{"id":"GO:0030103","count":7},{"id":"GO:0021707","count":7}]},{"hash":"1700547681579309427","title":"Diverse Transmembrane Transporters","description":"The GO terms cluster around transport across membranes for a range of substrates (nitrate/nitrite, galactose, sodium, vitamins, xenobiotics) and even neurotransmitter loading into synaptic vesicles, suggesting a set of proteins primarily functioning as membrane transporters with diverse substrate specificities. Despite no observed network edges, the shared theme is transmembrane transport activity across multiple molecules.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0015757","count":1},{"id":"GO:0015706","count":1}]},{"hash":"1283683088788557058","title":"Placental development and trophoblast differentiation","description":"The strongest and most coherent signal among the terms is placental development and trophoblast giant cell differentiation (GO:0060806, GO:0060707), with supportive hints from endocrine system development and Wnt signaling, all pointing to placental/embryonic lineage specification. Other terms reflect general RNA processing and transcription regulation, but the placental differentiation theme is dominant.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001970","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0000398","count":2}]},{"hash":"2289670665168739560","title":"Cuticle development and organismal morphogenesis","description":"The proteins are tied to larval chitin-based cuticle development and overall body morphogenesis, with supporting signals from BMP pathway regulation and multicellular development processes. This suggests a cohesive theme around exoskeleton formation and broader developmental patterning rather than a single enzymatic or metabolic function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0040003","count":1},{"id":"GO:0010171","count":1},{"id":"GO:0090191","count":1},{"id":"GO:0030513","count":1}]},{"hash":"92160287110289991","title":"Developmental signaling and tissue differentiation","description":"This cluster centers on signaling pathways that govern development and cell fate decisions (Wnt, Hippo), as well as processes for organ and tissue differentiation (heart valve development, keratinocyte differentiation) and linked proliferation/apoptosis control, suggesting a cohesive theme of signaling-mediated development across tissues. Some terms are broader (immune signaling, transcription regulation, DNA replication), but the dominant pattern is developmental signaling and differentiation.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060044","count":11},{"id":"GO:0090263","count":11},{"id":"GO:0033160","count":11},{"id":"GO:0030216","count":11},{"id":"GO:0035329","count":11}]},{"hash":"733243780371893840","title":"Developmental Morphogenesis","description":"The top GO terms cluster around developmental processes and morphogenesis (e.g., chitin-based cuticle development, body and hair follicle morphogenesis, and midbrain-hindbrain boundary organization), with a signaling component in PDGF receptor pathways. Some terms are obsolete or unrelated (RNA polymerase import, spliceosome), suggesting annotation noise. The lack of edges indicates these proteins don\u2019t form a tight, cohesive pathway, but they collectively point to broad developmental and morphogenetic roles.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":3},{"id":"GO:0010171","count":3},{"id":"GO:0048008","count":2},{"id":"GO:0002244","count":1},{"id":"GO:0021552","count":1}]},{"hash":"782135564881923895","title":"Glycolysis and Related Carbohydrate Metabolism","description":"The cluster primarily centers on central carbohydrate metabolism: canonical glycolysis, glyceraldehyde-3-phosphate biosynthesis, glycerol catabolic processes, and the pentose-phosphate shunt. These shared metabolic themes suggest a glycolysis-focused gene set, even though a few terms (acrosome reaction, chloroplast organization) appear unrelated and may reflect annotation noise. Overall, this label best captures the dominant function of the cluster.","confidence":"Medium","size":11,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":2},{"id":"GO:0016540","count":2},{"id":"GO:0080022","count":1},{"id":"GO:0006098","count":1},{"id":"GO:0046166","count":1}]},{"hash":"2001590922177612086","title":"Unknown","description":"The top terms span xenobiotic response, quinone biosynthesis, chromatin regulation, calcium ion detection, muscle fiber type switching, lung epithelial differentiation, blood vessel branching, morphine response, and excitatory synaptic potential, showing no single coherent function or pathway linking all proteins. This functional heterogeneity makes a specific, representative label inappropriate.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":4},{"id":"GO:0009234","count":2},{"id":"GO:0042372","count":2},{"id":"GO:0035562","count":2},{"id":"GO:0005513","count":2}]},{"hash":"1908468461676104137","title":"Unknown","description":"The Top Terms show a highly diverse set of processes\u2014from mitochondrial inheritance and nitrate assimilation to CNS myelin maintenance, ergosterol metabolism, nitric oxide biosynthesis, lipid biosynthesis, and ciliary movement\u2014without a single unifying function. There is no clear cohesive theme tying these GO terms together, so a specific label cannot be confidently assigned.","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0032286","count":1},{"id":"GO:0032443","count":1},{"id":"GO:0006809","count":1}]},{"hash":"190571768445452226","title":"Innate Immune Signaling and Phagocytic Activation","description":"The top GO terms cluster around innate immune receptor signaling (C-type lectin and Fc-gamma pathways), phagocytosis recognition, and leukocyte activation (basophils, NK cells), suggesting a shared role in immune sensing and phagocytic responses, with some developmental terms likely reflecting inflammation-associated remodeling.","confidence":"Medium","size":11,"edges":36,"triangles":50,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":8},{"id":"GO:0090403","count":8},{"id":"GO:0002223","count":8},{"id":"GO:0006910","count":8},{"id":"GO:0038094","count":8}]},{"hash":"585696393449424213","title":"Drug-responsive neuronal signaling and plasticity","description":"The top GO terms cluster around neuronal signaling, sensory processing, and learning, with emphasis on responses to psychoactive drugs (amphetamine, morphine), prepulse inhibition, regulation of sensory perception and pain, and various forms of synaptic transmission and plasticity (short-term, glutamatergic, visual learning). This suggests a cohesive theme of drug-responsive neuronal signaling and experience-dependent plasticity, despite some developmental terms (lateral line) present in a subset of proteins.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0060134","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0051967","count":3}]},{"hash":"33401198616610806","title":"Neuronal Synaptic Transmission and Plasticity","description":"This cluster centers on neuronal synapses: receptor clustering, regulation of synaptic transmission (including glutamatergic and neuromuscular transmission), and synaptic plasticity with ties to memory. Developmental terms for the lateral line system also point to sensory neuron involvement, supporting a cohesive theme of synapse-focused neural function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":4},{"id":"GO:0043523","count":4},{"id":"GO:0050806","count":3},{"id":"GO:0048915","count":3},{"id":"GO:0048899","count":3}]},{"hash":"1864424259981431775","title":"LPS-induced inflammatory signaling and necroptosis","description":"These proteins are collectively annotated with GO terms centered on innate immune sensing of lipopolysaccharide (detection of LPS, positive regulation of LPS-mediated signaling), inflammatory responses, and programmed cell death via necroptosis, as well as TNF production. This cluster appears to reflect a shared function in LPS-triggered inflammation and associated necroptotic signaling, despite a few outlier terms that may reflect broader or non-specific annotations. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0032760","count":1},{"id":"GO:0032497","count":1},{"id":"GO:0051345","count":1},{"id":"GO:0031666","count":1}]},{"hash":"2142130331569268389","title":"Chromatin modification and nucleosome remodeling","description":"Proteins in this cluster are linked primarily to histone modifications and nucleosome dynamics, including multiple histone methylation and deacetylation activities and nucleosome disassembly, with related chromatin regulatory components like the RITS complex and glucocorticoid signaling influencing transcription via chromatin. Some tissue development terms appear, but the dominant theme is chromatin modification and remodeling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901726","count":1},{"id":"GO:0051574","count":1},{"id":"GO:0061038","count":1},{"id":"GO:0034773","count":1},{"id":"GO:0033601","count":1}]},{"hash":"811396845426593733","title":"ER quality control and ERAD/retrograde transport","description":"The dominant GO terms point to endoplasmic reticulum localization (to ER membrane) and retrograde transport from the ER to the cytosol, which are core aspects of ER-associated degradation (ERAD) and ER quality control processes. A related term about localization to endosome suggests broader intracellular trafficking, but the ERAD/ER localization terms clearly anchor the cluster\u2019s function. The presence of an obsolete term for ubiquitin-dependent ERAD reinforces the theme, albeit with outdated wording. Overall, this cluster seems to group proteins involved in managing ER residency and clearance via ERAD pathways.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010936","count":1},{"id":"GO:0036010","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0030970","count":1},{"id":"GO:0097051","count":1}]},{"hash":"2145574496428838244","title":"Heat and light stress response with proteostasis","description":"The top GO terms point to stress responses to heat and high light, including regulation of cellular response to heat and response to heat/light. There is also a strong signal for proteostasis-related processes (protein stabilization and regulation of protein interactions) and ROS metabolism, suggesting a theme around maintaining protein function under stress. A few outliers touch on intracellular transport and lens development, but the dominant pattern fits a heat/light stress response coupled with protein homeostasis.","confidence":"Medium","size":10,"edges":8,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009644","count":3},{"id":"GO:0032387","count":3},{"id":"GO:0007568","count":3},{"id":"GO:1900034","count":3},{"id":"GO:0032463","count":3}]},{"hash":"2153710126109449957","title":"Diverse Metabolite Biosynthesis","description":"The Top Terms are dominated by biosynthetic processes for various compounds (estrogen, phylloquinone, mycolic acid, tropane alkaloids, retinol, PHB, very long-chain fatty acids) across different organisms, with an additional transcription regulation term. This points to a cluster centered on broad biosynthesis of diverse metabolites and lipids rather than a single pathway.","confidence":"Medium","size":10,"edges":11,"triangles":3,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006703","count":8},{"id":"GO:0031427","count":8},{"id":"GO:0042376","count":8},{"id":"GO:0046677","count":8},{"id":"GO:0071768","count":8}]},{"hash":"1246841392499355849","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":22,"triangles":35,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0048701","count":9},{"id":"GO:0009432","count":8},{"id":"GO:0000184","count":7},{"id":"GO:0000398","count":7}]},{"hash":"1086591315636041132","title":"Innate Immune Signaling and Antifungal Defense","description":"This cluster is dominated by GO terms tied to innate immune responses and inflammation: positive regulation of Toll signaling, leukocyte migration in inflammatory response, neutrophil-mediated killing of fungus, and response to yeast. Additional terms about plasminogen activation and fibrinogen regulation also fit inflammatory processes. Some terms (amelogenesis; regulation of transcription by RNA polymerase II; endodeoxyribonuclease activity) appear as outliers. Overall, the proteins seem enriched for innate immune signaling and antifungal defense functions.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:1902947","count":3},{"id":"GO:0097186","count":3},{"id":"GO:0044537","count":3},{"id":"GO:0045752","count":3}]},{"hash":"1910524983631403063","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000480","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0008584","count":2}]},{"hash":"909265020894572297","title":"Diverse membrane solute transporters","description":"The cluster is enriched for GO terms related to transmembrane transport of multiple substrates (xenobiotics, nitrate/nitrite, galactose, sodium, vitamins, phosphate) and vesicular neurotransmitter loading, indicating a common function as membrane transport proteins across diverse substrates.","confidence":"High","size":10,"edges":29,"triangles":33,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0015757","count":1},{"id":"GO:0015706","count":1},{"id":"GO:0035725","count":1}]},{"hash":"993071525510560277","title":"Cytoskeletal Dynamics and Mitosis","description":"The dominant GO terms point to cytoskeletal organization (cytoplasmic microtubule organization), mitosis and cytokinesis (cell cycle, mitotic cytokinesis, spindle pole body duplication, FtsZ-dependent cytokinesis), and septum-related division processes. This suggests the cluster centers on cytoskeletal remodeling and the machinery of cell division. A few terms like neuron migration and interleukin-4 response may reflect broader signaling contexts that utilize similar cytoskeletal components, but the core theme is cytoskeleton-driven cell division.","confidence":"High","size":10,"edges":30,"triangles":56,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001764","count":7},{"id":"GO:0090529","count":7},{"id":"GO:0071353","count":7},{"id":"GO:0007049","count":7},{"id":"GO:1905789","count":7}]},{"hash":"1399658000190742897","title":"Bone and cartilage differentiation signaling","description":"This cluster is dominated by GO terms tied to bone and cartilage development, including positive regulation of osteoblast differentiation, BMP signaling, MAPK cascade, and chondrocyte differentiation, suggesting a shared role in skeletal formation and growth signaling. While a few terms relate to other processes, the prevailing themes point to bone/cartilage development and its regulatory pathways.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045669","count":2},{"id":"GO:0043568","count":2},{"id":"GO:0043410","count":2},{"id":"GO:0002062","count":1},{"id":"GO:1902731","count":1}]},{"hash":"373672107136758924","title":"BMP/TGF-beta signaling and transcriptional regulation","description":"This cluster centers on developmental signaling and gene regulation, with GO terms for DNA-templated transcription, DNA replication/cell division, SMAD/BMP/TGF-beta signaling, and somite axis specification, plus synapse maturation hints. Despite a couple obsolete terms, the strongest theme is BMP/TGF-beta\u2013mediated signaling linked to transcriptional control during development.","confidence":"Medium","size":10,"edges":13,"triangles":8,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0007183","count":2},{"id":"GO:0007179","count":2},{"id":"GO:1903715","count":2}]},{"hash":"713280241319307391","title":"Unknown","description":"The top GO terms are highly diverse, ranging from chromatin localization and heterochromatin formation to metabolic, cell-cycle, immune, plant development, and viral latency processes. There\u2019s no clear, cohesive function tying these proteins together, so a single intuitive label cannot be assigned.","confidence":"","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":2},{"id":"GO:0030466","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0050900","count":1}]},{"hash":"847180148868407964","title":"Nuclear RNA transport and processing proteins","description":"The top GO terms cluster around nuclear import/export of RNA and RNA-binding proteins (NLS-bearing import, hnRNP import, mRNA export, ribosomal subunit export) and RNA processing/ transcription regulation, suggesting a cohesive set of factors involved in nuclear RNA handling and related cell-cycle processes.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006607","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006406","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0001824","count":3}]},{"hash":"1946895900030231200","title":"Ubiquitin-dependent proteostasis and ER stress responses","description":"The top GO terms center on ubiquitin-mediated quality control (ERAD pathway, autoubiquitination) and stress responses (aggresome assembly, ER-stress\u2013related apoptosis), suggesting a cluster of proteins involved in maintaining protein homeostasis under stress, with some signals toward vesicle trafficking and mitochondrial dynamics that may reflect broader stress adaptation.","confidence":"Medium","size":10,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0051865","count":3},{"id":"GO:0014070","count":3},{"id":"GO:0017085","count":2},{"id":"GO:1902236","count":2}]},{"hash":"1832121253756771876","title":"Axon guidance and neural development","description":"The dominant signals in the GO terms are axon extension and guidance (including commissural axon guidance), neural crest cell migration, and nervous system organization, indicating a core theme of neuronal development and axon pathfinding. While there are some terms related to vascular development and general multicellular development, they are secondary to the neural guidance pattern in this cluster.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048842","count":4},{"id":"GO:0002042","count":3},{"id":"GO:0048846","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0045880","count":3}]},{"hash":"704496093142918046","title":"Spliceosome Assembly and RNA Processing","description":"The cluster is enriched for spliceosomal components (snRNP and spliceosomal complex assembly) and RNA maturation processes (tRNA processing, maturation of SSU-rRNA, histone mRNA metabolism) as well as transcription termination, suggesting a cohesive role in RNA processing and spliceosome function, with some additional RNA metabolism links such as nuclear import and P-body assembly.","confidence":"High","size":10,"edges":34,"triangles":57,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":4},{"id":"GO:0051170","count":3},{"id":"GO:0000387","count":3},{"id":"GO:0042633","count":3},{"id":"GO:0006369","count":3}]},{"hash":"2053316218932981899","title":"Developmental signaling and lipid homeostasis","description":"The top GO terms cluster around developmental processes (multicellular organism growth, vagina development), signaling regulation (NF-kappaB signaling, positive regulation of gene expression), membrane-related activities (protein transmembrane transport, nuclear import), and lipid handling (cholesterol and phospholipid homeostasis). This suggests a group of proteins involved in membrane-associated signaling that coordinates growth/development with lipid metabolism and inflammatory-like responses.","confidence":"Medium","size":10,"edges":15,"triangles":5,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":6},{"id":"GO:0043124","count":6},{"id":"GO:0000060","count":5},{"id":"GO:0071806","count":5},{"id":"GO:0071222","count":4}]},{"hash":"1637267199415927048","title":"Oxidative Stress Response and Redox Homeostasis","description":"The cluster is dominated by GO terms tied to redox balance and detoxification, including cellular redox homeostasis, cellular oxidant detoxification, and response to toxic substances, plus involvement in reactive oxygen species signaling (superoxide generation) and vacuolar/lysosomal processes. While there are a few developmental or signaling terms (CNS development, ERK cascade regulation) and an immune-related term (lipopolysaccharide response), the strongest and most consistent theme across the set is management of oxidative stress and redox status, suggesting these proteins work together to maintain redox homeostasis and detoxification under stress or inflammatory conditions.","confidence":"High","size":10,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":8},{"id":"GO:0098869","count":8},{"id":"GO:2000255","count":8},{"id":"GO:0007417","count":7},{"id":"GO:0070373","count":7}]},{"hash":"1266406511140064395","title":"RNA splicing and translation regulation","description":"This cluster is enriched for spliceosome-mediated mRNA splicing and regulation of alternative splicing, indicating core RNA processing components. It also includes terms related to translation initiation and assembly of the eIF4F complex, suggesting a link between RNA processing and translational control, with a note of small-subunit processome involvement. Together, the proteins appear to function in post-transcriptional RNA processing and regulation of translation.","confidence":"Medium","size":10,"edges":30,"triangles":35,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:1903586","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0006378","count":2},{"id":"GO:1900363","count":2}]},{"hash":"1615427053104580435","title":"mRNA Splicing and Translational Regulation","description":"The GO terms show a clear emphasis on mRNA splicing via the spliceosome, plus multiple layers of post-transcriptional control including regulation of translation initiation and miRNA-mediated silencing, as well as stress-related mRNA stability regulation. Together these indicate a cohesive cluster focused on RNA processing and translational control rather than transcriptional regulation.","confidence":"High","size":10,"edges":26,"triangles":30,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":8},{"id":"GO:0010610","count":8},{"id":"GO:1903586","count":7},{"id":"GO:0035278","count":7},{"id":"GO:0006378","count":7}]},{"hash":"715194413431722077","title":"Small-molecule membrane transporters","description":"The top GO terms indicate transmembrane transport of a variety of small molecules (glucose, fructose, xylose, arabinose, nitrite, xenobiotics) and vesicular loading of neurotransmitters, suggesting a cohesive cluster of transporter proteins specialized in small-molecule uptake and vesicle loading rather than other functions.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:1990539","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0098700","count":1},{"id":"GO:0042891","count":1}]},{"hash":"185800289443761643","title":"RNA splicing and translation initiation regulation","description":"The cluster includes terms tied to RNA processing via the spliceosome and small-subunit processome, plus regulation of translation initiation and EIF4F complex assembly, as well as miRNA-mediated translational silencing. Although some GO terms are obsolete, the remaining terms collectively point to a cohesive theme of mRNA maturation and control of protein synthesis.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1903586","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0006378","count":3},{"id":"GO:1900363","count":3},{"id":"GO:1905663","count":3}]},{"hash":"819263572575890149","title":"Insect Cuticle Development and Innate Immune Signaling","description":"The top GO terms point to larval chitin-based cuticle development and positive regulation of peptidoglycan recognition protein (PGRP) signaling. This suggests the cluster may contain insect proteins involved in both exoskeleton (cuticle) formation and innate immune signaling, possibly reflecting a link between development and immune regulation. However, with only two low-frequency terms, the connection is plausible but not strongly evidenced, so a moderate confidence is appropriate.","confidence":"Medium","size":10,"edges":30,"triangles":47,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0061059","count":1}]},{"hash":"1901780300504158265","title":"TGF-beta Driven Tissue Remodeling","description":"The top GO terms emphasize positive regulation of TGF-beta receptor signaling, tissue remodeling, and endothelial/smooth muscle dynamics, along with cell migration and matrix adhesion regulation, indicating a cohesive program of extracellular remodeling and vascular/muscle tissue dynamics driven by TGF-beta\u2013related signaling.","confidence":"High","size":10,"edges":16,"triangles":9,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030511","count":5},{"id":"GO:1902043","count":4},{"id":"GO:0034103","count":4},{"id":"GO:0006986","count":4},{"id":"GO:2000353","count":4}]},{"hash":"1687345685313272025","title":"Larval chitin-based cuticle development","description":"The cluster is dominated by the GO term for larval chitin-based cuticle development, suggesting these proteins co-function in insect larval cuticle formation and hardening; the uniform enrichment implies a cohesive role in this developmental process.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":8}]},{"hash":"300076879169643815","title":"Unknown","description":"There are 10 proteins, but no GO terms are listed (Top Terms is empty), so a shared function can\u2019t be inferred. The network shows some connectivity, but without functional annotations, a specific, representative label isn\u2019t supported. ","confidence":"","size":10,"edges":25,"triangles":19,"max_degree":8,"top_function":null,"top_go_terms":[]},{"hash":"573517708824233394","title":"Ribosome biogenesis and rRNA maturation","description":"The top GO terms are dominated by rRNA processing (maturation of SSU, 5.8S, and LSU rRNA) and ribosomal large subunit biogenesis, with translation also represented. This suggests a cluster of proteins involved in ribosome assembly and RNA maturation rather than signaling or metabolic pathways. The presence of spliceosome-related and autophagy-related terms appears ancillary, but the core theme centers on ribosome production and rRNA maturation.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":3},{"id":"GO:0000466","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2}]},{"hash":"1074326920399717047","title":"Ubiquitin-Dependent Apoptosis and NF-kB Signaling","description":"The cluster is enriched for ubiquitin-related processes (ubiquitin-dependent protein catabolic process, polyubiquitination, K6-linked ubiquitination) and immune signaling components, including positive regulation of TNF-mediated signaling and I-kappaB phosphorylation, which point to NF-kB\u2013driven control of apoptosis and immune responses. It also contains terms related to antiviral transport and V(D)J recombination, suggesting involvement of ubiquitin pathways in adaptive immunity.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0000209","count":4},{"id":"GO:0042981","count":4},{"id":"GO:1903265","count":4},{"id":"GO:1901253","count":4}]},{"hash":"1429814084432778194","title":"Development with ER stress-driven apoptosis","description":"This cluster is enriched for developmental terms (neural tube and forebrain development, skeletal system development) alongside transcription-related terms and stress responses, notably ER-stress-induced apoptosis and cadmium response, suggesting a theme of developmental programs coordinated with stress signaling.","confidence":"Medium","size":10,"edges":8,"triangles":5,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0070059","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0000278","count":7}]},{"hash":"275140256265987657","title":"Golgi-ER Vesicle Trafficking","description":"The top GO terms cluster around vesicle movement and organization related to the Golgi and related pathways (retrograde Golgi-to-ER transport, Golgi organization, vesicle docking), with related trafficking activities like melanosome transport and vacuole targeting, pointing to a common theme of intracellular membrane trafficking rather than a single enzyme function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0007030","count":3},{"id":"GO:0032402","count":2},{"id":"GO:0006904","count":2},{"id":"GO:0032258","count":2}]},{"hash":"870901659380151025","title":"Proteoglycan Biosynthesis and Metabolism","description":"The cluster\u2019s top GO terms are dominated by dermatan sulfate, heparan/chondroitin sulfate proteoglycan biosynthesis and related metabolic processes, pointing to a core role in glycosaminoglycan production and extracellular matrix assembly; mentions of chondrocyte development and ureteric bud formation suggest broader developmental roles in cartilage and kidney morphogenesis, all supporting a proteoglycan/ECM\u2013related theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030208","count":3},{"id":"GO:0015014","count":3},{"id":"GO:0002063","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0015015","count":3}]},{"hash":"252039623297729930","title":"Unknown","description":"The top GO terms span endocytosis, neuronal survival, actin dynamics, hormone signaling, immune signaling, and cell division with no single unifying function, so a cohesive label is not identifiable.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":1},{"id":"GO:0043524","count":1},{"id":"GO:0090135","count":1},{"id":"GO:0071389","count":1},{"id":"GO:0033144","count":1}]},{"hash":"123322105100113391","title":"Sperm lipid catabolism and acrosome reaction","description":"Based on the GO terms, this cluster centers on lipid catabolism and remodeling (phosphatidylethanolamine and phosphatidylcholine catabolic processes, triglyceride mobilization and acyl-chain remodeling), along with signaling elements (negative regulation of cAMP-dependent protein kinase activity) and Ca2+ transport across the plasma membrane, plus an acrosome reaction term. The convergence of triglyceride turnover and phospholipid catabolism with an acrosome reaction suggests a role in sperm-specific lipid remodeling and the exocytotic events required for fertilization.","confidence":"High","size":10,"edges":29,"triangles":30,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0046338","count":5},{"id":"GO:2000480","count":5},{"id":"GO:0034638","count":5},{"id":"GO:0098703","count":5},{"id":"GO:0006642","count":5}]},{"hash":"1184463673480765263","title":"Translation initiation and mRNA processing","description":"The cluster is dominated by GO terms related to forming the translation preinitiation complex, translation reinitiation, and regulation of translational initiation, indicating a focus on translational control. Additional terms point to mRNA processing/splicing, suggesting these proteins participate in broader RNA metabolism with an emphasis on translation initiation regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:1903586","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0006378","count":2}]},{"hash":"221588203396879652","title":"Antigen presentation and immune activation","description":"The terms cluster around antigen processing and presentation via MHC I/II, TAP-dependent pathways, T cell cytokine production, NK cell protection, and phagocytosis recognition, indicating an immune activation theme. Some entries reference glycosaminoglycan biosynthesis and retina homeostasis, but the dominant signal points to adaptive/innate immune functions.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0019886","count":2},{"id":"GO:0002726","count":2},{"id":"GO:0001895","count":2}]},{"hash":"1159739831107265039","title":"Proteoglycan biosynthesis and tissue morphogenesis","description":"The top GO terms cluster around proteoglycan biosynthesis (chondroitin sulfate proteoglycan biosynthetic process, UDP-D-xylose metabolic process) and related glycosylation steps, which feed into extracellular matrix construction. This is coupled with tissue morphogenesis, kidney morphogenesis, and cell adhesion-related terms, suggesting a coherent theme of proteoglycan-ECM production guiding tissue development and adhesion processes. There is one outlier term (inter-male aggressive behavior) that is not central to the others and likely non-specific; overall the pattern supports a proteoglycan synthesis\u2013driven morphogenesis role.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060993","count":1},{"id":"GO:0050650","count":1},{"id":"GO:0002121","count":1},{"id":"GO:0033319","count":1},{"id":"GO:0030206","count":1}]},{"hash":"1742903884412744028","title":"GTPase signaling and vesicle trafficking","description":"The top GO terms center on small GTPase activity (Rac, general small GTPase signaling) and vesicle trafficking processes (calcium-dependent exocytosis, ER-to-Golgi transport), suggesting the proteins work together to coordinate cytoskeletal dynamics and membrane trafficking during migration. Some terms about hepatocyte apoptosis and dendritic spine development may reflect broader regulatory roles rather than core features of the cluster.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0035021","count":2},{"id":"GO:1902953","count":2}]},{"hash":"936582087323139727","title":"Lipid remodeling and immune signaling","description":"The top GO terms cluster around lipid metabolism/remodeling (phosphatidylglycerol, phosphatidic acid, phosphatidylserine remodeling; lysophospholipid transport; LDL particle remodeling) together with immune-related processes (innate immune response in mucosa, macrophage activation regulation, prostaglandin secretion, ERK signaling). This suggests a theme where lipid remodeling modulates immune/inflammatory signaling, rather than a single isolated function. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0002227","count":1},{"id":"GO:0036148","count":1},{"id":"GO:0006654","count":1},{"id":"GO:0051977","count":1}]},{"hash":"1108998956102851693","title":"DNA Damage Response and Chromatin Regulation","description":"This cluster centers on DNA damage response and chromatin regulation: DSB processing, ER-stress\u2013induced apoptotic signaling, and a suite of histone modifications and ubiquitination/neddylation. The combination of transcriptional regulation and meiosis-related synaptonemal complex organization may reflect shared regulatory mechanisms or cross-talk in stress responses.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043524","count":10},{"id":"GO:0050852","count":10},{"id":"GO:0000729","count":10},{"id":"GO:0031058","count":10},{"id":"GO:0035519","count":10}]},{"hash":"1313553407516422358","title":"Inositol and phosphatidylinositol biosynthesis","description":"The dominant GO terms are phosphatidylinositol biosynthetic processes and inositol biosynthetic process, indicating a core function in generating inositol and PI lipids. Additional terms point to related carbohydrate metabolism and plant osmotic stress signaling (ABA activation and hyperosmotic salinity response), suggesting a broader metabolic and stress-response context rather than a single cohesive process. Viral terms appear incidental noise. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0042538","count":3},{"id":"GO:0046854","count":3},{"id":"GO:0006021","count":3}]},{"hash":"2224171923531255563","title":"Centrosome and mitotic spindle assembly","description":"The top GO terms include maintenance of centrosome location, mitotic spindle assembly, and gamma-tubulin complex localization to the mitotic spindle pole body, all pointing to involvement in the mitotic apparatus and spindle organization. While other terms are more peripheral, these core signals suggest a cluster of proteins associated with centrosome and spindle functions.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051661","count":1},{"id":"GO:0010735","count":1},{"id":"GO:1903478","count":1},{"id":"GO:0014809","count":1},{"id":"GO:1990735","count":1}]},{"hash":"1313162022295346173","title":"Epigenetic DNA Methylation and Chromatin Regulation","description":"The terms are dominated by DNA methylation across contexts (CG/CHG/CHH), methylation-dependent heterochromatin formation, and regulation of histone methylation, all pointing to epigenetic control of chromatin state and gene expression. An outlier angiogenesis term appears, but the core signal centers on chromatin-based regulation by methylation marks. High","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0090116","count":1},{"id":"GO:0010426","count":1},{"id":"GO:0043046","count":1},{"id":"GO:0051573","count":1}]},{"hash":"1749006641080164701","title":"Neural synaptic transmission and plasticity","description":"This cluster is dominated by GO terms about regulation of synaptic transmission (positive and negative), short- and long-term neural plasticity, glutamatergic signaling, and memory, with supporting neural development terms such as lateral line and cerebellar granule cell differentiation, indicating a neural signaling and memory-focused theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050806","count":2},{"id":"GO:0048915","count":2},{"id":"GO:0048899","count":2},{"id":"GO:0048172","count":2},{"id":"GO:0051967","count":2}]},{"hash":"1932494773263293320","title":"Tissue development and ECM remodeling","description":"This cluster centers on developmental processes and extracellular matrix-related activities, including endodermal differentiation, chondrocyte proliferation, growth plate cartilage development, amelogenesis, and basement membrane organization, suggesting a cohesive theme of tissue differentiation and ECM remodeling. Some terms (spore germination, cellular responses to stimuli) are less coherent with this theme, but the dominant signals point to developmental and ECM-related functions.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009847","count":1},{"id":"GO:0035987","count":1},{"id":"GO:0097186","count":1},{"id":"GO:0071260","count":1},{"id":"GO:1900122","count":1}]},{"hash":"1216877618058445147","title":"Neurodevelopment and organ morphogenesis","description":"The top GO terms point to developmental processes across neural tissues (neurohypophysis development, forebrain cell proliferation, glial differentiation, brain segmentation) and other organs (heart development, cochlea morphogenesis, nephric duct elongation, chondrocyte differentiation), all centered on morphogenesis and development rather than a single pathway. This suggests the cluster represents proteins broadly involved in developmental and morphogenetic processes across multiple organs. ","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":9},{"id":"GO:0021985","count":9},{"id":"GO:0021846","count":9},{"id":"GO:0010001","count":9},{"id":"GO:0035284","count":9}]},{"hash":"318646604350371531","title":"Proteostasis and organelle quality control","description":"These proteins point to a theme of maintaining protein homeostasis and organelle health under stress: translation machinery, aggresome assembly, ERAD- and autophagy-related regulation, and mitochondrial dynamics, with accompanying signaling pathways (e.g., TNF signaling and calcium channel regulation) that modulate stress responses. While a few terms are less directly tied, the overall cluster centers on proteostasis, protein quality control, and organelle maintenance.","confidence":"Medium","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0070842","count":7},{"id":"GO:1905366","count":7},{"id":"GO:1903265","count":7},{"id":"GO:0045648","count":7}]},{"hash":"2076634911012048104","title":"Embryonic Development and Cell Fate Regulation","description":"This cluster centers on transcriptional regulation and diverse developmental processes, including neural crest migration, endothelial and cardiac development, endodermal fate specification, and gland development, all pointing to embryo-wide lineage specification governed by transcriptional control. The terms span multiple tissues but share a common theme of developmental regulation rather than a single, specific pathway, hence a Developmental regulation label. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0001755","count":2},{"id":"GO:0001935","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0003290","count":1}]},{"hash":"326977832316027346","title":"Neural development and cholinergic GPCR signaling","description":"The top GO terms cluster around brain development, neuron remodeling, and G protein-coupled acetylcholine receptor signaling, with supporting signals such as glucose-mediated signaling and GTPase regulation, suggesting a neural development and signaling module rather than a general housekeeping set.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0016322","count":3},{"id":"GO:0007213","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0001501","count":3}]},{"hash":"619446828696043250","title":"Neurodevelopment and craniofacial formation","description":"This cluster is dominated by terms tied to neural development and craniofacial formation, including neural crest cell migration, brain development and segmentation, glial differentiation, axon extension, and odontogenesis. The presence of visual perception and forebrain proliferation hints at retina and brain\u2013eye development as well. Together these terms point to a coherent theme of neural crest\u2013derived craniofacial tissues and neural development.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042475","count":2},{"id":"GO:0001755","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0030516","count":2},{"id":"GO:0007517","count":2}]},{"hash":"1063336094662205122","title":"Neurotransmitter GPCR signaling and immune regulation","description":"Top GO terms cluster around GPCR-mediated signaling involving adrenergic, opioid, and dopaminergic pathways, along with endocrine and immune-related processes such as insulin secretion regulation and inflammatory/immune differentiation. This suggests a cohesive theme of neurotransmitter-driven GPCR signaling influencing neuroendocrine functions and immune responses.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050796","count":4},{"id":"GO:0050728","count":4},{"id":"GO:0043950","count":3},{"id":"GO:0001994","count":3},{"id":"GO:0051482","count":3}]},{"hash":"2049939662230498862","title":"Adaptive immune cell differentiation","description":"The top GO terms are dominated by immune-related differentiation: positive regulation of dendritic cell differentiation, pro-T cell differentiation, memory T cell differentiation, and germinal center formation, suggesting a cluster centered on adaptive immune lineage commitment. Some terms (phototropism, gravitropism) appear as unrelated noise, but the core signal supports an immune differentiation theme, potentially involving ubiquitination in signaling. Therefore, a label focused on adaptive immune cell differentiation best fits the cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":6},{"id":"GO:2001200","count":6},{"id":"GO:0043380","count":6},{"id":"GO:0032764","count":6},{"id":"GO:2000176","count":6}]},{"hash":"1509913395312008687","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":17,"triangles":20,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0008306","count":7},{"id":"GO:0071049","count":6},{"id":"GO:1900050","count":6},{"id":"GO:1902775","count":6},{"id":"GO:1990416","count":6}]},{"hash":"2066912442494306402","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0035372","count":5},{"id":"GO:0042098","count":4},{"id":"GO:1903883","count":4}]},{"hash":"746281730471483719","title":"Pathogen Entry and Genome Integration","description":"These terms cluster around mechanisms of host cell entry (endocytosis, symbiont entry) and integration of genetic material into the host genome (DNA transposition, DNA integration, proviral latency), pointing to a theme of genome invasion by mobile elements or pathogens and their interaction with host processes; some terms (pre-B cell differentiation, muscle contraction) appear less connected and may reflect annotation noise.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0046718","count":3}]},{"hash":"612838526081472239","title":"Developmental apoptosis and stress signaling","description":"The terms cluster around apoptosis (neuron/glial apoptotic processes and its regulation) and various stress responses (xenobiotic stimulus, glucocorticoid response, hypoxia), with a developmental hint (heart development), suggesting a theme of developmentally regulated, stress-induced apoptotic signaling.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0034349","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0045736","count":2}]},{"hash":"1622734725326795047","title":"Unknown","description":"The terms mix immune cell differentiation (dendritic cell differentiation, pro-T cell differentiation, T cell differentiation, germinal center formation, memory T cell regulation) with plant-specific tropisms (phototropism, gravitropism) and ubiquitination, giving no clear, cohesive biological theme. This suggests annotation noise or cross-species mismatches, so a concise, representative label cannot be confidently assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904431","count":3},{"id":"GO:1900477","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0043380","count":2},{"id":"GO:0032764","count":2}]},{"hash":"465091358435204567","title":"Environmental sensory responses and photoprotection","description":"This cluster includes GO terms for environmental sensing (magnetoreception, response to magnetism, gravitaxis), photoprotection/UV protection, and oxidative/dna damage responses (cellular response to hydrogen peroxide, circadian regulation of calcium oscillation, signal transduction in response to DNA damage). The common theme is organisms sensing and defending against environmental light- and stress-related cues, with circadian modulation, suggesting a cohesive \u201cenvironmental sensing and photoprotection\u201d function.","confidence":"Medium","size":9,"edges":13,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":2},{"id":"GO:0050958","count":2},{"id":"GO:2000323","count":2},{"id":"GO:0071000","count":2},{"id":"GO:0009650","count":2}]},{"hash":"65013290354833148","title":"DNA replication and chromatin regulation","description":"The terms cluster around DNA replication, cell cycle control, and chromatin remodeling, with connections to chromosome condensation, histone modification, and meiotic DNA repair, suggesting a nuclear genome maintenance program. Some GO terms appear as outliers (lymphangiogenesis, lipid A biosynthesis, glucose signaling), likely annotation noise, but the dominant theme points to replication and chromatin regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006986","count":2},{"id":"GO:1905213","count":2},{"id":"GO:1990918","count":2},{"id":"GO:0001946","count":2}]},{"hash":"803825615996387182","title":"RNA Splicing and Processing","description":"The dominant GO terms describe RNA biogenesis and post-transcriptional control: spliceosome-mediated mRNA splicing (cis splicing and processome assembly), regulation of translational initiation, and miRNA-mediated silencing. An outlier term for larval cuticle development is likely incidental. Overall, the cluster centers on RNA processing and post-transcriptional regulation rather than other processes.","confidence":"High","size":9,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:1903586","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0006378","count":2},{"id":"GO:1900363","count":2}]},{"hash":"1380428688107043615","title":"Post-transcriptional gene regulation","description":"The cluster is dominated by GO terms tied to RNA processing and control of gene expression after transcription: alternative mRNA splicing regulation, miRNA-mediated silencing, and regulation of translational initiation, along with related mRNA polyadenylation processes. This points to a cohesive theme of post-transcriptional regulation, with some supporting signals from deubiquitination-related processes that can influence protein turnover in regulatory networks. Confidence reflects strong alignment to post-transcriptional regulation.","confidence":"High","size":9,"edges":32,"triangles":58,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":6},{"id":"GO:1903586","count":4},{"id":"GO:0035278","count":4},{"id":"GO:1990168","count":4},{"id":"GO:0006378","count":4}]},{"hash":"1220959208312949268","title":"Unknown","description":"The top terms show a mix of larval chitin-based cuticle development and several unrelated processes, including lipid metabolism (sphingosine/sphinganine), phospholipid dephosphorylation, transport, signaling, and detoxification, with no single cohesive biological process uniting all proteins. Confidence: None","confidence":"","size":9,"edges":15,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0015760","count":1},{"id":"GO:0006668","count":1},{"id":"GO:0006670","count":1},{"id":"GO:0035233","count":1}]},{"hash":"929695777613159110","title":"Developmental morphogenesis and reproductive processes","description":"The cluster shows GO terms for body morphogenesis, muscle and skeletal development, and chitin-based cuticle formation, alongside reproductive-related terms such as ovarian follicle development, copulation, and GnRH signaling, suggesting a group of proteins involved in developmental patterning with reproductive maturation; regulatory terms and antibacterial responses appear as minor associated functions.","confidence":"Medium","size":9,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":2},{"id":"GO:0010171","count":2},{"id":"GO:0043392","count":1},{"id":"GO:0007620","count":1},{"id":"GO:0048747","count":1}]},{"hash":"1857941451869216082","title":"T cell activation and NF-kappaB signaling","description":"The cluster shows GO terms centered on adaptive immune activation: positive regulation of T cell activation via TCR-MHC engagement, T cell costimulation, and dendritic cell differentiation, along with positive regulation of canonical NF-kappaB signaling, plus a cellular response to virus. Together these indicate an immune-activation module with NF-kappaB\u2013mediated signaling; a few terms (like root hair development) appear as noise and do not negate the main immune theme.","confidence":"Medium","size":9,"edges":8,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":1},{"id":"GO:0045598","count":1},{"id":"GO:0098586","count":1},{"id":"GO:0034120","count":1},{"id":"GO:0010812","count":1}]},{"hash":"1145887553898440397","title":"Stress-Responsive RNA Regulation","description":"The cluster shows signals of cellular stress responses (insulin stimulus, hypoxia, ischemia) together with RNA-focused regulatory processes (miRNA-mediated silencing, mRNA localization, polyadenylation), suggesting a module that links stress signaling to post-transcriptional RNA regulation and translation control.","confidence":"Medium","size":9,"edges":13,"triangles":7,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0032869","count":5},{"id":"GO:0002931","count":3},{"id":"GO:1903586","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0071230","count":3}]},{"hash":"770575396442495230","title":"Peripheral nerve development and cytoskeletal organization","description":"Dominant GO terms cluster around somatic motor neuron differentiation, Schwann cell migration regulation, and neurofilament cytoskeleton organization, with links to musculoskeletal movement and collagen biosynthesis, suggesting a focus on peripheral nervous system development, axon maintenance, and myelination. A few unrelated terms (intestinal lipid catabolic process, pancreatic juice secretion) appear as single instances and may reflect annotation noise rather than a core theme. ","confidence":"Medium","size":9,"edges":16,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0044258","count":1},{"id":"GO:0030157","count":1},{"id":"GO:0018350","count":1},{"id":"GO:0050881","count":1},{"id":"GO:0021523","count":1}]},{"hash":"1837600100398525146","title":"RNA Splicing and Transcription Regulation","description":"The strongest signals are RNA processing terms (RNA splicing and regulation of alternative splicing) and transcriptional control (negative regulation of RNA Pol II transcription), suggesting this cluster centers on RNA maturation and gene expression regulation. A few terms appear less connected (cuticle and heart development) and may reflect annotation noise, but the RNA-centric theme remains dominant. Overall, this label best captures the cluster\u2019s core functions.","confidence":"Medium","size":9,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:1990168","count":1},{"id":"GO:0006977","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0090526","count":1}]},{"hash":"787330971419446070","title":"Unknown","description":"The GO terms are highly diverse, spanning muscle and skeletal development, reproductive development, immune response, and transcription regulation, with no single dominant process. The cluster also has no edges, indicating a lack of cohesive functional linkage, so a specific label is not supported.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043392","count":2},{"id":"GO:0007620","count":2},{"id":"GO:0048747","count":2},{"id":"GO:2000354","count":2},{"id":"GO:0001501","count":2}]},{"hash":"505156724813249013","title":"Innate Immune Signaling and Apoptosis","description":"The cluster is dominated by innate immune and stress-related terms, including innate immune response, MDA-5 signaling, and apoptotic process. Additional terms like hypoxia response and UV protection suggest a broader cellular stress context. While there are DNA replication and developmental terms present, they are less central to the top signals, implying a functional theme around immune sensing and programmed cell fate rather than a single cohesive pathway.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0009650","count":3},{"id":"GO:0009307","count":3}]},{"hash":"1335269929065358829","title":"Golgi-ER transport and mitotic cell cycle regulation","description":"The terms emphasize vesicle trafficking between the Golgi and ER (retrograde and ER-to-Golgi transport) along with cell cycle progression (G1/S transition and cell division). Additional terms point to signaling (TORC1) and regulation of GTPase activity, which can coordinate trafficking and mitotic processes. Overall, this cluster seems to center on Golgi-ER transport coupled with cell-cycle signaling and progression.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043666","count":3},{"id":"GO:0000082","count":3},{"id":"GO:0006890","count":2},{"id":"GO:0070262","count":2},{"id":"GO:0038202","count":2}]},{"hash":"1344998747007825065","title":"Nuclear transcription and DNA repair","description":"Most of the top GO terms are nuclear processes: transcription by RNA polymerase I and nucleotide-excision repair, with a third term about RNA Pol II CTD phosphorylation (obsolete). A few terms relate to endosomal sorting/ESCRT pathways, which may reflect annotation noise or multifunctional proteins rather than a cohesive trafficking module. Therefore, the dominant theme appears to be nuclear gene expression and DNA maintenance.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006360","count":3},{"id":"GO:0006289","count":3},{"id":"GO:0070816","count":3},{"id":"GO:0032456","count":1},{"id":"GO:1904669","count":1}]},{"hash":"2150278823335044324","title":"Translation and Ribosome Dynamics","description":"The top GO terms are dominated by translation-related processes, including translation, mitochondrial translation, translational termination, and ribosome disassembly, with additional mRNA deadenylation-dependent decay linked to translation. A couple of neural-related terms (BDNF response, glial proliferation) appear, but the strongest signal is the protein synthesis and ribosome machinery.","confidence":"High","size":9,"edges":10,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0032543","count":3},{"id":"GO:0000288","count":2},{"id":"GO:0002244","count":2},{"id":"GO:0002184","count":2}]},{"hash":"398371030042241919","title":"Eye development and cilium assembly","description":"This cluster is dominated by eye-related terms: lens fiber cell differentiation, retina development in camera-type eye, and cilium assembly, pointing to functions in eye morphogenesis and photoreceptor ciliary structure. The additional metabolic terms likely reflect incidental associations rather than a coherent alternative theme. Hence, the name reflects the strongest shared function among proteins in this cluster.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0060271","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0008283","count":2}]},{"hash":"27153172172249280","title":"Mitotic Division and Vesicle Trafficking","description":"The top terms are dominated by mitosis-related processes (mitotic spindle assembly, mitotic cell cycle, cell division) and cell proliferation, suggesting a mitosis-centric core. Vesicle trafficking terms (COPII-coated vesicle budding, Golgi-to-ER transport) imply coordination of division with intracellular transport, with transcription providing general cellular context. Together, they point to a theme of mitotic progression coupled with essential transport mechanisms.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0090114","count":2}]},{"hash":"163503885013536047","title":"RNA Decay and Transcription Regulation","description":"Reasoning: The strongest signals are about mRNA turnover\u2014deadenylation and decapping pathways\u2014and processing-body-related regulation, along with transcription elongation by RNA polymerase II. While a few terms touch on developmental processes, the dominant theme across the cluster points to RNA metabolism and transcription control.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008258","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0001829","count":1},{"id":"GO:0000749","count":1},{"id":"GO:0000288","count":1}]},{"hash":"2032999420774903194","title":"Neuronal development and cytoskeletal dynamics","description":"The dominant terms include hippocampus development, regulation of neuron apoptotic processes, and filopodium assembly, all pointing to neuronal differentiation and neurite outgrowth. Additional terms about cell cycle, mitotic spindle assembly, and morphogenesis hint at concurrent proliferation/cellular remodeling, but the strongest signal is neuron development and cytoskeletal remodeling. Therefore a label focusing on neuronal development with cytoskeletal dynamics best captures the cluster\u2019s functionality.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021766","count":5},{"id":"GO:0007049","count":5},{"id":"GO:0043525","count":5},{"id":"GO:0043524","count":4},{"id":"GO:0090307","count":4}]},{"hash":"1092391867979810528","title":"Unknown","description":"The GO terms span highly diverse processes (stress responses to toxins and nitrosative/NO signaling, hypoxia, nitrogen fixation) plus development and maturation terms (heart, erythrocytes) with only single-term representations and no clear shared function, making a coherent cluster label inappropriate.","confidence":"","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":1},{"id":"GO:0010764","count":1},{"id":"GO:0051409","count":1},{"id":"GO:0009399","count":1},{"id":"GO:0051291","count":1}]},{"hash":"1015955976861338216","title":"Unknown","description":"Top terms span steroid metabolism, vitamin and lipid biosynthesis/catabolism, and drug/antibiotic responses, with no single shared pathway; plus no edges, giving no coherent cluster function.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":1},{"id":"GO:0006703","count":1},{"id":"GO:0006706","count":1},{"id":"GO:0031427","count":1},{"id":"GO:0042376","count":1}]},{"hash":"859086724079966453","title":"Cardiovascular signaling and angiogenesis","description":"The top GO terms point to signaling pathways and developmental processes in the cardiovascular system, notably Wnt signaling, endothelial cell proliferation in sprouting angiogenesis, and heart-specific communication (SA node to atrial cardiomyocytes), as well as mechanotransduction. While other terms like cell cycle, pinocytosis, and ubiquitination are broader, the common theme is signal transduction steering cardiovascular development and function, including angiogenesis and mechanosensitive responses.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048549","count":5},{"id":"GO:0016055","count":5},{"id":"GO:0007049","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0016477","count":5}]},{"hash":"573084928883222904","title":"Nematode development and reproductive processes","description":"The top GO terms are dominated by nematode-specific developmental and reproductive functions: nematode pharyngeal pumping, molting cycle with cuticle, polyspermy prevention, maternal axis specification, and embryonic morphogenesis, with some proteolysis activity. While a few terms are more general or obsolete, the recurring nematode-focused processes strongly suggest a cluster tied to nematode development and reproduction.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0055114","count":2},{"id":"GO:2000360","count":2},{"id":"GO:0035124","count":2},{"id":"GO:0048632","count":2}]},{"hash":"1824262456522157633","title":"Cardiovascular development and angiogenesis regulation","description":"The cluster is dominated by GO terms tied to vascular and heart development, including sprouting and general angiogenesis, as well as ossification. Terms like negative regulation of angiogenesis and heart development point to a developmental and remodeling program in the cardiovascular system. Additional terms such as chemokine production, phagocytosis of apoptotic cells, and glucose response suggest broader tissue remodeling and metabolic-immune interactions that often accompany developing vasculature. While there are some outliers, the core signal centers on cardiovascular development and angiogenesis, supporting a cohesive label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0000187","count":2},{"id":"GO:0002040","count":2},{"id":"GO:0048661","count":2},{"id":"GO:0009749","count":2}]},{"hash":"1412661439151855709","title":"Retroviral Entry and Proviral Latency","description":"The set of top GO terms centers on viral entry into the host nucleus, establishment of integrated proviral latency, and DNA-level processes like recombination and replication, plus RNA-templated DNA biosynthesis. These collectively point to a retroviral life cycle with genome integration and latency as core features, making this cluster representative of retroviral infection and proviral maintenance. The presence of host response terms like regulation of siRNA processing suggests host-virus interaction dynamics, reinforcing the theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2}]},{"hash":"2117759350071491017","title":"Developmental Processes and Cell Cycle","description":"The terms cluster around embryonic development and cell proliferation (cell division, mitotic cell cycle, multicellular development, skeletal system development, neural tube closure) with supporting transcription activity (DNA-templated transcription). Additional entries reflect cellular stress responses (ER-stress\u2013triggered apoptosis, cadmium/cellular stress) and defense signaling, suggesting a cohesive theme of development coupled with proliferation and stress signaling.","confidence":"Medium","size":9,"edges":16,"triangles":12,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0070059","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0050830","count":5}]},{"hash":"997931776001844770","title":"Protein synthesis and ER\u2013Golgi trafficking","description":"The top GO terms emphasize translation initiation (formation of translation preinitiation complex, translation reinitiation) and vesicle-mediated transport between the endoplasmic reticulum and Golgi apparatus, pointing to a cluster centered on protein production and trafficking through the secretory pathway. Other terms are broader context signals (nutrient response, proliferation), but the strongest shared theme is translation machinery coupled with ER\u2013Golgi transport.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007584","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0060770","count":4}]},{"hash":"1048019147414980625","title":"Organogenesis and tissue development","description":"The GO terms cluster around developmental processes across multiple tissues (bone/mineralization, lung alveolus, digestive tract, body morphogenesis), with some terms about differentiation and morphogenesis. Because there is no strong, single pathway connecting them and the terms span various organ systems, the label reflects a general developmental/morphogenetic theme rather than a specific function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060038","count":1},{"id":"GO:0048286","count":1},{"id":"GO:0032332","count":1},{"id":"GO:0042997","count":1},{"id":"GO:0030501","count":1}]},{"hash":"645470617297166251","title":"Meiotic DNA Repair and Recombination","description":"Proteins in this cluster are linked predominantly to DNA repair and meiotic recombination processes: nucleotide-excision repair, UV-damage repair, meiotic mismatch repair, and intra-S DNA damage checkpoint signaling, plus sister chromatid movement related to meiosis. The recurring theme across the GO terms points to genome integrity maintenance during meiosis, with a few annotation artifacts (e.g., flagellum terms) that do not define the core function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010777","count":1},{"id":"GO:1902209","count":1},{"id":"GO:0010224","count":1},{"id":"GO:0006289","count":1},{"id":"GO:0044781","count":1}]},{"hash":"1506180894205854246","title":"Ubiquitin-Dependent NF-\u03baB Signaling","description":"The terms cluster around ubiquitination (K63/K48, autoubiquitination), ubiquitin-dependent proteolysis/ERAD, and positive regulation of NF-kappaB signaling and TNF pathways, indicating these proteins function in ubiquitin-mediated regulation of NF-\u03baB.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070534","count":6},{"id":"GO:0051092","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0043123","count":6},{"id":"GO:0042787","count":6}]},{"hash":"951690783292031730","title":"Leukocyte activation and Fc receptor signaling","description":"The proteins cluster around immune signaling and leukocyte effector functions, as shown by GO terms for phagocytosis, Fc-gamma receptor signaling, C-type lectin receptor signaling, basophil activation, NK cell regulation, and platelet activation. While there are a few development-related terms (lymph vessel morphogenesis, cartilage condensation, metanephric limb development), the dominant theme is immune cell activation and signaling, justifying this label.","confidence":"Medium","size":9,"edges":18,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":9},{"id":"GO:0090403","count":9},{"id":"GO:0002223","count":9},{"id":"GO:0006910","count":9},{"id":"GO:0038094","count":9}]},{"hash":"1744934271652545068","title":"Membrane Sugar and Xenobiotic Transporters","description":"The GO terms cluster around transmembrane transport of diverse substrates (sugars like fructose, glucose, xylose, arabinose; nitrite; xenobiotics) and related uptake processes, plus a vesicle-related transport term. This suggests a common function group of membrane transporters facilitating substrate import/export, despite limited network connectivity. The set likely comprises transporter proteins or membrane-associated proteins involved in nutrient and xenobiotic transport.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:1990539","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0098700","count":1},{"id":"GO:0042891","count":1}]},{"hash":"879747746076014605","title":"Plant cell wall carbohydrate biosynthesis","description":"This cluster centers on sugar metabolism and cell-wall\u2013related polysaccharide biosynthesis, with GO terms for glycogen, trehalose, UDP-sugars, (1\u21926)-beta-D-glucan, callose deposition, and sulfolipids, plus a cell-wall stress response signal (phosphate starvation) and a programmed cell death term. The strongest common theme is synthesis and modification of plant cell wall carbohydrates and related metabolic pathways, pointing to roles in wall integrity and defense/stress responses. The apoptotic and starvation terms suggest broader stress signaling as well, but the core pattern remains wall carbohydrate biosynthesis.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0005992","count":1},{"id":"GO:0052573","count":1},{"id":"GO:0006078","count":1}]},{"hash":"2221979705148710647","title":"Unknown","description":"The listed GO terms span GPCR-Ca2+ signaling and cAMP production, neural development (axon guidance, cortical regionalization), organ development (lung branching, seminiferous tubule development), vascular/immune signaling, and behavioral stress responses. With 9 proteins and no observed interactions (Edges 0, Triangles 0, Max Degree 0), there isn\u2019t a single cohesive function tying them together, so no specific, representative label can be confidently assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032792","count":2},{"id":"GO:0036515","count":2},{"id":"GO:0007200","count":2},{"id":"GO:0060488","count":2},{"id":"GO:0072520","count":2}]},{"hash":"1198040954632344009","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030317","count":1},{"id":"GO:0090435","count":1},{"id":"GO:0007052","count":1},{"id":"GO:0051642","count":1},{"id":"GO:0051663","count":1}]},{"hash":"183467715049142015","title":"Neural development and sensory signaling","description":"The terms are dominated by nervous system development and sensory-related signaling: dendrite development, synapse organization, cochlea morphogenesis, vocalization behavior, and receptor guanylyl cyclase signaling. Rho signaling supports cytoskeletal dynamics in neurons. While a few terms touch on epithelial or kidney processes, the core theme centers on neural structure and sensory pathways, making this label a reasonable representation of the cluster's functional emphasis.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090557","count":1},{"id":"GO:0007266","count":1},{"id":"GO:0050808","count":1},{"id":"GO:0006470","count":1},{"id":"GO:0071625","count":1}]},{"hash":"442911340820988215","title":"Diverse Biosynthesis and Sporulation","description":"The top GO terms span several biosynthetic and metabolic pathways (antibiotic biosynthesis, pyridoxine/vitamin B6 biosynthesis, serine and alanine biosynthesis), plus steroid-related metabolism (androgen and estrogen biosynthesis, steroid catabolic process) and a sporulation term. The mix suggests broad metabolic potential rather than a single, cohesive function for the cluster, with sporulation as an additional developmental association. Confidence in a single unified function is therefore moderate, reflecting this diversity.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0030435","count":3},{"id":"GO:0042853","count":2},{"id":"GO:0008615","count":2}]},{"hash":"1784258248438892806","title":"Inflammation and NF-kappaB activation","description":"The top GO terms cluster around inflammatory signaling and stress responses, notably cellular responses to interleukin-1 and interleukin-6, and activation of NF-kappaB-inducing kinase, with apoptosis also represented. Some terms (cuticle development, ecdysis) seem peripheral or annotation-related, but the core theme ties to inflammatory signaling and NF-kappaB pathways. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0071347","count":2},{"id":"GO:0000272","count":2},{"id":"GO:0070741","count":2}]},{"hash":"925439732929322125","title":"Unknown","description":"The Top Terms are a mix of viral-related terms (viral life cycle, proviral latency, fusion of virus membrane with host) and unrelated processes (leukocyte migration, plant sepal formation), with no clear, single biological theme tying them together. Because the terms do not converge on a cohesive function or pathway, I cannot assign a specific, meaningful label beyond Unknown.","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050900","count":2},{"id":"GO:0000413","count":2},{"id":"GO:0048453","count":2},{"id":"GO:0050714","count":2},{"id":"GO:0071492","count":2}]},{"hash":"400165627213596288","title":"RNA and protein methyltransferases","description":"The cluster is dominated by GO terms for RNA methylation (tRNA methylation, rRNA guanine-N7 methylation, tRNA wobble uridine modification) and protein N-terminal methylation/trimethylation, suggesting a shared function as methyltransferases acting on RNA and nascent peptides. Minor cofactor biosynthesis terms appear less central, likely reflecting neighboring functions rather than core activity.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":2},{"id":"GO:0018013","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0070476","count":2},{"id":"GO:0090502","count":2}]},{"hash":"299925597040333768","title":"Xenobiotic Detoxification and Lipid Metabolism","description":"These proteins appear to form a detoxification and lipid-metabolism module. The top GO terms highlight cellular oxidant detoxification and response to toxic substances, indicating xenobiotic handling, while several catabolic processes (glucuronoside, prostaglandin, triglyceride, alkaloid, among others) point to broader metabolism of lipids and small molecules. The regulation of endocannabinoid signaling further ties into lipid-mediated signaling pathways. Together, these suggest a functional cluster focused on detoxification coupled with lipid metabolism.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0009636","count":5},{"id":"GO:2000124","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0009820","count":4}]},{"hash":"1114046877969682243","title":"Unknown","description":"The top GO terms span disparate areas, including vitamin/cofactor metabolism (retinol, tetrahydrofolate, thiamine), antibiotic biosynthesis, responses to lipopolysaccharide and xenobiotics, and developmental processes (in utero embryonic development, extracellular matrix disassembly, Hedgehog signaling). There is no single cohesive function uniting these terms, and the cluster shows no interactions (edges), suggesting little functional coupling. Therefore, a reliable, unified label cannot be assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0032496","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0042572","count":2},{"id":"GO:0046653","count":2}]},{"hash":"401212078495870176","title":"Brain development and axon guidance","description":"Top GO terms are dominated by neural development signals (brain development and axon guidance), with learning also represented, suggesting the cluster reflects neuronal connectivity and maturation; other terms point to general cellular processes, but neural terms are strongest and most coherent.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0007411","count":3},{"id":"GO:0009410","count":2},{"id":"GO:0010513","count":2},{"id":"GO:1902824","count":2}]},{"hash":"1140622245589570211","title":"Renal development and steroid hormone metabolism","description":"The cluster shows a clear focus on kidney biology, with terms like inner medullary collecting duct development, renal system development, and renal water homeostasis. It also includes steroid hormone biosynthesis/metabolism terms (androgen metabolic process, C21-steroid hormone biosynthetic process), suggesting a link between renal function and steroid hormones. A few terms (jasmonic acid response, pyridoxal biosynthesis) appear less related, likely noise. Overall, this cluster aligns best with renal development influenced by steroid hormones.","confidence":"Medium","size":8,"edges":9,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":1},{"id":"GO:0042821","count":1},{"id":"GO:0072061","count":1},{"id":"GO:0003091","count":1},{"id":"GO:0006700","count":1}]},{"hash":"1086998074855165108","title":"Unknown","description":"The top terms span RNA processing (methylation and splicing), neural/glial apoptosis, immune/homeostatic processes, protein ubiquitination, GPCR\u2013PLC signaling, developmental pattern formation, SREBP signaling, and nutrient response. This diversity provides no single clear function tying the cluster, so a concise, representative label isn\u2019t supported.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0036265","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0034349","count":4},{"id":"GO:0051402","count":4},{"id":"GO:0043029","count":3}]},{"hash":"1216659559146567922","title":"RNA and protein methylation machinery","description":"The cluster is dominated by GO terms for methylation, including rRNA methylation, tRNA wobble uridine modification, arginine methylation, and histone methylation, indicating a shared function in methyltransferase activity. Some associated terms (polyamine and cobalamin biosynthesis) point to methyl-donor metabolism supporting methylation reactions, while other terms like cellular senescence and nodulation may be broader contextual connections. Overall, the cohesive theme is methylation processes across RNA, protein, and chromatin substrates.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":2},{"id":"GO:0002098","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0019919","count":2},{"id":"GO:0090398","count":2}]},{"hash":"1763845226369282872","title":"B cell signaling and membrane transport","description":"The top GO terms include immune-related processes (Wnt signaling pathway, germinal center formation, B cell receptor signaling pathway) alongside various transmembrane transport processes ( xenobiotic, nitrate, galactose, sodium, vitamin, fucose transport). This pattern suggests a cluster of membrane-associated proteins linked to B cell signaling and diverse substrate transport. Confidence: Medium","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2}]},{"hash":"781991326884929050","title":"Unknown","description":"The GO terms are highly diverse and span memory, heart development, autophagy, cytokinesis regulation, hypoxia response, DNA binding regulation, mitochondrial calcium regulation, and even karyogamy, with only one annotation per term. There is no clear shared function or pathway tying the proteins together, so there is no coherent cluster theme to label beyond Unknown.","confidence":"","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":1},{"id":"GO:0016237","count":1},{"id":"GO:0007614","count":1},{"id":"GO:0032465","count":1},{"id":"GO:0071456","count":1}]},{"hash":"1644354311589767403","title":"Larval chitin-based cuticle development","description":"The cluster is dominated by GO terms for larval chitin-based cuticle development and related cuticle formation, with additional connection to body morphogenesis. This indicates proteins likely involved in larval cuticle biosynthesis/remodeling, a cohesive insect epidermal process.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0040003","count":1},{"id":"GO:0010171","count":1}]},{"hash":"1949565647083306558","title":"Larval chitin-based cuticle development","description":"The cluster is enriched for GO terms tied to chitin-based cuticle development and body morphogenesis, especially in larvae, suggesting proteins involved in larval cuticle formation during body shaping. Despite no reported interactions, the shared terms indicate a cohesive developmental/cuticle function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":5},{"id":"GO:0010171","count":5},{"id":"GO:0008363","count":1}]},{"hash":"1670731755776282027","title":"Cellular stress response and protein quality control","description":"The GO terms point to proteostasis and stress handling (unfolded protein response, xenobiotic response, autophagy/microautophagy, endocytic recycling) and signaling regulation (negative regulation of kinase activity), suggesting a functional cluster centered on maintaining protein homeostasis and modulating signaling under stress. Some development-related terms appear, but they are less indicative of a single cohesive process for the cluster. Confidence: Medium","confidence":"","size":8,"edges":15,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0000278","count":2}]},{"hash":"97755302209153297","title":"Larval cuticle formation and body morphogenesis","description":"The top GO terms indicate larval chitin-based cuticle development, specifically cuticle formation, along with body morphogenesis. This points to a cohesive function in forming the larval cuticle and shaping body structure during development, supported by two shared terms with similar focus.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0040003","count":2},{"id":"GO:0010171","count":2}]},{"hash":"747478540615764522","title":"Yeast autophagy and vacuolar targeting","description":"The top terms are dominated by autophagy-related processes in yeast, including piecemeal microautophagy of the nucleus, nucleophagy, and the cytoplasm-to-vacuole targeting (Cvt) pathway, plus related vesicle trafficking and post-translational modifications (e.g., neddylation, urmylation) that affect protein turnover and membrane dynamics. This combination points to a coherent theme of autophagy and vacuolar protein turnover under nutrient stress in yeast.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0018192","count":4},{"id":"GO:0009228","count":4},{"id":"GO:0006501","count":4},{"id":"GO:0034727","count":4},{"id":"GO:0045116","count":4}]},{"hash":"1196174890815577954","title":"Actin dynamics in dendrites and lymphocytes","description":"This cluster centers on actin cytoskeleton remodeling and protrusive activity, with terms like Arp2/3-mediated actin nucleation, filopodium assembly, and actin filament capping. It also includes neuronal growth-related processes (dendrite extension, collateral sprouting, brain-derived neurotrophic factor response) and immune-related processes (negative regulation of lymphocyte migration, T cell antigen processing/presentation). Together these terms suggest a unifying role for actin-driven remodeling in both neuronal dendrite dynamics and lymphocyte behavior, justifying the label.","confidence":"High","size":8,"edges":23,"triangles":31,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:2000402","count":4},{"id":"GO:0051491","count":4},{"id":"GO:0044397","count":4},{"id":"GO:0048669","count":4},{"id":"GO:1990416","count":4}]},{"hash":"1384144805102999271","title":"Actin Cytoskeleton Remodeling and Cell Motility","description":"This cluster is dominated by GO terms for actin nucleation and actin filament network formation, along with positive regulation of pseudopodium and filopodium assembly, pointing to actin-driven cytoskeletal remodeling and protrusive cell movement. Additional terms on mitochondrial fission regulation and some developmental processes likely reflect actin\u2019s broader roles in organelle dynamics and development. Overall, the shared theme is actin-based cytoskeleton dynamics linked to cell motility.","confidence":"High","size":8,"edges":16,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045010","count":2},{"id":"GO:0051639","count":2},{"id":"GO:0090140","count":2},{"id":"GO:0031274","count":2},{"id":"GO:0008363","count":2}]},{"hash":"1185929832600310213","title":"Larval Chitin-Based Cuticle Development","description":"Based on the strongest, most frequent GO term in the cluster (larval chitin-based cuticle development), the proteins appear to be tied to larval cuticle formation and development. The other terms are few and largely obsolete or peripheral, suggesting the central theme is cuticle biology rather than other processes. ","confidence":"High","size":8,"edges":7,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5},{"id":"GO:0002931","count":1},{"id":"GO:1903586","count":1},{"id":"GO:0035278","count":1},{"id":"GO:0071230","count":1}]},{"hash":"200142185976040788","title":"Neuronal Synaptic Transmission and Plasticity","description":"Top terms indicate a core theme of neural signaling and plasticity, with positive and negative regulation of synaptic transmission, short-term plasticity, and memory-related processes (long- and medium-term memory), complemented by neuronal developmental terms such as cerebellar granule cell differentiation. A few terms relate to sensory-neural development (lateral line), while a fungicide response appears as a less coherent outlier. Overall, the cluster appears to represent neuronal communication and memory-related functions.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050806","count":2},{"id":"GO:0048915","count":2},{"id":"GO:0048899","count":2},{"id":"GO:0048172","count":2},{"id":"GO:0051967","count":2}]},{"hash":"1812520836998406351","title":"Unknown","description":"The GO terms are diverse, covering energy metabolism, immune signaling, lipid response, cell motility, neural development, junction assembly, VEGF signaling, and vacuolar protein catabolism, with no clear shared function tying the proteins together.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042773","count":1},{"id":"GO:1901223","count":1},{"id":"GO:0071404","count":1},{"id":"GO:2000145","count":1},{"id":"GO:0014005","count":1}]},{"hash":"106208392873533972","title":"Retroviral Integration and Proviral Latency","description":"The cluster is dominated by GO terms tied to DNA replication, DNA integration, recombination, and RNA-templated DNA biosynthesis, along with viral entry into the host nucleus and establishment of integrated proviral latency. These collectively point to the retroviral life cycle involving reverse transcription, genome integration, and proviral latency, with some additional terms reflecting host-pathogen interactions and defense modulation. Confidence reflects a strong, specific link to viral genome integration and latency functions.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0015074","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0006310","count":6}]},{"hash":"1845334403776851119","title":"Neural development and axon guidance","description":"The top GO terms cluster around brain development, neuron projection development, axon guidance, neural crest cell migration, and related synaptic and cytoskeletal processes (e.g., regulation of Rho signaling and synaptic vesicle exocytosis). This points to a coherent set of proteins involved in neuronal differentiation, neurite outgrowth, and pathfinding during development, with a minor outlier term that does not detract from the overall neural-development theme.","confidence":"High","size":8,"edges":9,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0031384","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0010796","count":2}]},{"hash":"175657810532806314","title":"Neuronal development and GTPase signaling","description":"The top GO terms cluster around nervous system development, dendritic spine development, and small GTPase-mediated signal transduction, suggesting proteins involved in neuron formation, connectivity, and cytoskeletal regulation. Some terms are more generic or obsolete (e.g., hair follicle placode formation, intermembrane transport, and mitotic spindle assembly), but the dominant theme points to neuronal development and signaling. Confidence in this thematic label is Moderate.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060999","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0060789","count":3},{"id":"GO:0046909","count":3},{"id":"GO:0007399","count":3}]},{"hash":"1367813455020353200","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around neural development and synaptic function: nervous system and hippocampus development, excitatory postsynaptic potential, cellular response to dopamine, and regulation of ERK/MAPK signaling and Wnt signaling, all of which are central to neuronal development and synaptic signaling. A few terms (like T cell receptor signaling) may be incidental noise or cross-annotation, but the dominant theme is neural development and synaptic activity.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":8},{"id":"GO:0000186","count":8},{"id":"GO:0090263","count":8},{"id":"GO:0050852","count":8},{"id":"GO:1903351","count":8}]},{"hash":"204970899434282670","title":"Developmental chromatin regulation and cell cycle control","description":"The top GO terms cluster around chromatin dynamics (negative regulation of chromatin binding, histone dephosphorylation), cell cycle progression (G1/S transition), and meiotic DNA repair, with supporting developmental processes (mesoderm development, lymphangiogenesis). This points to a theme where chromatin state and cell cycle control intersect during development and meiotic recombination.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007498","count":3},{"id":"GO:0006986","count":2},{"id":"GO:1905213","count":2},{"id":"GO:1990918","count":2},{"id":"GO:0001946","count":2}]},{"hash":"886188096987900257","title":"Amino acid and cofactor biosynthesis with redox response","description":"This cluster is dominated by biosynthetic processes (glutamate, leucine, NADP+ biosynthesis) and the glutathione metabolic pathway, coupled with oxidative stress response terms. The presence of hormone response and lipid metabolism terms suggests additional links to steroid signaling and membrane biology, but the core theme appears to be metabolic biosynthesis tied to redox balance. Overall, the group seems cohesive around building blocks and cofactors while managing oxidative stress, with secondary hormone-related signals.","confidence":"Medium","size":8,"edges":18,"triangles":16,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006537","count":3},{"id":"GO:0006749","count":3},{"id":"GO:0008585","count":2},{"id":"GO:0048545","count":2},{"id":"GO:0006979","count":2}]},{"hash":"1769348515440166457","title":"Transcription and Translation Regulation","description":"Top GO terms indicate regulation at both transcriptional (DNA-templated transcription, post-transcriptional tethering) and translational levels (formation of translation preinitiation complex, translation reinitiation, regulation of translational initiation), with GCN2-mediated signaling connecting nutrient status to translation control. Additional terms point to roles in cell proliferation and stem cell differentiation, supporting a theme of coordinated gene expression control. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0034260","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0060733","count":2}]},{"hash":"1485641648982001208","title":"Skin and hair follicle development with wound healing","description":"The top GO terms point to skin-related processes (keratinization, hair follicle development) alongside vascular and coagulation processes and wound healing, suggesting a cluster centered on skin biology, hair follicle biology, and tissue repair involving vasculature and extracellular remodeling. PI3K/AKT signaling involvement supports growth and repair functions in this context.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":1},{"id":"GO:0036345","count":1},{"id":"GO:0051897","count":1},{"id":"GO:0033690","count":1},{"id":"GO:0010575","count":1}]},{"hash":"889611993964711639","title":"Neural signaling and sensory development","description":"The cluster highlights ion transport (sodium, potassium, chloride), GABA signaling, and excitatory postsynaptic potential terms, along with sensory system development (optic nerve morphogenesis, inner ear receptor cell development) and behavior-related terms (locomotory behavior, conditioned taste aversion, response to cocaine), suggesting proteins involved in neuronal signaling and sensory system development rather than a single metabolic pathway.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":7},{"id":"GO:0035725","count":6},{"id":"GO:0007214","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0042220","count":6}]},{"hash":"2035355723415595951","title":"Cell Fate Signaling and Proliferation","description":"These proteins show enrichment in pathways that regulate cell growth, differentiation, and developmental signaling (Wnt and Hippo), with terms related to heart development (cardiac proliferation, valve morphogenesis) and apoptosis. Although some terms touch on other contexts (keratinocyte differentiation, Fc signaling), the dominant theme is signaling networks governing proliferation and fate decisions in development. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060044","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0030216","count":6},{"id":"GO:0035329","count":6},{"id":"GO:0006915","count":6}]},{"hash":"1455619535837576431","title":"Neurotransmitter uptake and amino acid transport","description":"These terms point to neural signaling and amino acid/monoamine handling: glycine secretion/import, dopamine and serotonin uptake, and dopamine catabolism all reflect neurotransmitter cycling, while proline transport and glycine import emphasize amino acid movement. The neural-development terms (adenohypophysis and thalamus development) further support a nervous-system context. The absence of edges suggests this is a shared functional theme rather than a strict interaction network.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061537","count":1},{"id":"GO:1905847","count":1},{"id":"GO:0015824","count":1},{"id":"GO:0051583","count":1},{"id":"GO:0042066","count":1}]},{"hash":"1266684047561755847","title":"Neural sensory signaling with xenobiotic stress","description":"Terms include dopamine regulation, phototransduction, and smell, pointing to neural sensory signaling; additional xenobiotic response and immune-related terms suggest broader stress signaling, but the core cluster centers on sensory/neural processes.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042053","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0007603","count":2},{"id":"GO:0090398","count":2},{"id":"GO:0050852","count":1}]},{"hash":"368013681223688576","title":"Proteoglycan Biosynthesis and ECM Sulfation","description":"The top GO terms cluster around glycosaminoglycan biosynthesis and sulfation of proteoglycans (heparan and keratan sulfate), including N-acetylglucosamine metabolism and peptidyl-tyrosine sulfation, which together point to extracellular matrix assembly and post-translational modification of secreted proteins. The presence of embryonic neurocranium morphogenesis further supports a developmental ECM role. Xenobiotic and other metabolic terms are secondary but can reflect broad metabolic capacity of cells, not central to the cluster's core function.","confidence":"High","size":8,"edges":11,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006711","count":4},{"id":"GO:0006068","count":4},{"id":"GO:0015015","count":4},{"id":"GO:0006044","count":4},{"id":"GO:0006478","count":4}]},{"hash":"554669057996962298","title":"Proviral Integration and Latency","description":"The top GO terms point to viral/proviral processes: DNA integration, reverse transcription (RNA-templated DNA biosynthesis), DNA replication and recombination, viral entry into the host nucleus, and establishment of integrated proviral latency, with an additional hint at suppression of RNA silencing. This combination supports a cohesive theme of genomes integrating into host DNA and being maintained in latency, characteristic of proviral activity.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2}]},{"hash":"1895673567214908745","title":"Developmental BMP signaling with inflammation","description":"This cluster centers on GO terms tied to development, especially BMP signaling and morphogenesis (multicellular organism development, BMP signaling, imaginal disc-derived morphogenesis), while also showing immune/inflammatory activity (positive regulation of chemokine production, inflammatory response, production of inflammatory mediators) and host interaction (symbiont entry into host cell). The coexistence of developmental and inflammatory terms suggests a theme of developmental signaling integrated with immune modulation, with some insect-specific processes like chitin metabolism contributing to the context. Confidence: Medium","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0006032","count":1}]},{"hash":"1454789658268784083","title":"Developmental morphogenesis and differentiation","description":"This cluster\u2019s terms cluster around broad developmental processes\u2014muscle (sarcomere organization, heart development), neural development (neuron differentiation, axon guidance, ventricular neuroblast division), and signaling (positive regulation of BMP signaling)\u2014all pointing to morphogenesis and lineage differentiation across tissues rather than a single pathway or function. The mix across organ systems supports a general developmental theme rather than a narrow function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":3},{"id":"GO:1904706","count":2},{"id":"GO:0030513","count":2},{"id":"GO:0048803","count":2},{"id":"GO:0021859","count":2}]},{"hash":"1472869289671599208","title":"Developmental signaling and differentiation","description":"This cluster includes terms tied to signaling and fate decisions across multiple tissues (BMP signaling, vascular smooth muscle differentiation, T cell and CD8 T cell regulation), plus neural development processes (neuron differentiation, neural crest migration, axon guidance) and even imaginal disc morphogenesis. The common thread is broad developmental signaling and differentiation rather than a single specific pathway, hence this generalized label.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":2},{"id":"GO:1905065","count":2},{"id":"GO:0030513","count":1},{"id":"GO:0048803","count":1},{"id":"GO:1905404","count":1}]},{"hash":"908299740885387595","title":"Brain and Sensory System Development","description":"The top GO terms cluster around development of neural and sensory tissues: brain development, visual perception, retinal bipolar neuron differentiation, and semicircular canal formation, indicating coordinated formation of the brain and sensory organs (eye and inner ear). Some outliers include heart/cartilage development, but the strongest signal is neural/sensory organ development. ","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0060040","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0051216","count":2}]},{"hash":"294659415300936659","title":"Cardio-craniofacial and placental development","description":"The proteins are enriched for heart development, face development, placenta development, cartilage growth, and enamel mineralization, pointing to a developmental/organogenesis theme across multiple tissues (cardiovascular, craniofacial/dental, placental, skeletal). Included regulatory terms like DNA-templated transcription and the p38 MAPK cascade support coherent developmental networks. While a few terms are broad or incidental, the overall pattern strongly reflects developmental processes.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0070166","count":4},{"id":"GO:0060324","count":4},{"id":"GO:0006351","count":4},{"id":"GO:2001275","count":4}]},{"hash":"1883213875610667825","title":"Multicellular Development and Reproduction","description":"The top GO terms are dominated by developmental processes across tissues (osteoblast differentiation, brain development, male gonad development, multicellular organism growth, single fertilization), suggesting a cluster centered on development and reproductive biology; the other terms touch on cellular mechanisms that often accompany development (chromatin assembly, ER stress\u2013related apoptosis, ERAD, and cell cycle regulation), which supports a broader developmental context but adds some complexity. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001649","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0061641","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0007338","count":2}]},{"hash":"187075869946493506","title":"Neural development and synaptic wiring","description":"This cluster is dominated by GO terms tied to nervous system development, nerve impulse transmission, retina morphogenesis, myelination, synapse organization, and neuronal signaling, suggesting a cohesive function in neural development and the assembly of neural circuits.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007422","count":5},{"id":"GO:0019226","count":5},{"id":"GO:0060060","count":5},{"id":"GO:0060168","count":5},{"id":"GO:0042552","count":5}]},{"hash":"867254994144756366","title":"Glycoprotein Biosynthesis in Epithelial Development","description":"The GO terms converge on glycosylation-based processes (arabinogalactan protein metabolism, poly-N-acetyllactosamine biosynthesis, O-linked glycosylation) and epithelial development features (follicle cell adhesion, maintenance of polarity), suggesting a theme of cell-surface glycoprotein production shaping epithelial organization during development. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":3},{"id":"GO:0046208","count":2},{"id":"GO:0007299","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0075015","count":2}]},{"hash":"1716552775519727947","title":"Broad Metabolic Biosynthesis and Catabolism","description":"This cluster shows enrichment across multiple metabolic processes, including amino acid catabolism (L-aspartate, L-alanine), biosynthesis of cofactors and vitamins (biotin), lipid-related pathways (sphinganine, fatty acid homeostasis), and heme production, with only one outlier signaling term (Notch). The diversity suggests a general metabolic function rather than a single specific pathway, so a broad metabolism label is appropriate. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006533","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0042853","count":2},{"id":"GO:0034276","count":2},{"id":"GO:0019441","count":2}]},{"hash":"82628645471144110","title":"Ubiquitin-Dependent ERAD and Stress Response","description":"The top terms cluster around ubiquitin-mediated protein quality control, especially ER-associated degradation (ERAD), protein autoubiquitination, and aggresome assembly, indicating a core role in managing misfolded proteins and ER stress. Additional terms touch on ER-stress\u2013related apoptotic signaling, translation, and transcription regulation, suggesting broader links to how proteostasis influences gene expression. Some terms (insecticide response, TNF signaling) appear peripheral, but the dominant signal is proteostasis and stress response via ubiquitin pathways.","confidence":"Medium","size":7,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0051865","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0035186","count":2}]},{"hash":"960241274167608570","title":"Embryogenesis and placental morphogenesis","description":"The top GO terms cluster around embryonic development and tissue morphogenesis, with emphasis on placental/trophoblast differentiation, left-right patterning, and endocardial cushion formation. Terms for placenta, trophoblast, pancreas development, and morphogenetic processes suggest proteins that regulate early development and organ/tissue differentiation rather than a single pathway. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0003198","count":2}]},{"hash":"1712866607794841025","title":"Embryogenesis and organ morphogenesis","description":"The top GO terms coalesce around embryonic development and formation of tissues and organs: endocrine development, left-right axis formation, placental/trophoblast differentiation, heart EMT in the endocardial cushion, cartilage morphogenesis, and pancreatic cell development. This suggests proteins tied to developmental differentiation and organ morphogenesis rather than a single enzymatic function; transport terms are present but less central. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014070","count":2},{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0060972","count":1}]},{"hash":"1423575729455808023","title":"Molybdenum cofactor biosynthesis and sulfur metabolism","description":"The top GO terms cluster around Mo cofactor biosynthesis and related sulfur pathways, including molybdenum incorporation into the Mo-molybdopterin complex, sulfate assimilation, cysteine and glutathione biosynthesis, and hydrogen sulfide production. A few receptor-clustering terms appear but are likely incidental noise; the dominant theme is MoCo biosynthesis and sulfur metabolism.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032324","count":1},{"id":"GO:0019379","count":1},{"id":"GO:0097112","count":1},{"id":"GO:0018315","count":1},{"id":"GO:0072579","count":1}]},{"hash":"2168232637775853003","title":"Unknown","description":"The top GO terms span nuclear transport, chromosome/dna dynamics, cytoskeletal signaling, and viral processes, with no single cohesive function tying them together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":7,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090138","count":2},{"id":"GO:0086091","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0006609","count":2},{"id":"GO:0045465","count":2}]},{"hash":"168634066165389200","title":"Clathrin-Mediated Endocytosis and Endosomal Trafficking","description":"The cluster shows a strong signature of vesicle trafficking: clathrin coat assembly, endocytosis, and late endosome to vacuole transport via MVB sorting. These terms point to a module of receptor internalization and endosomal sorting, with additional signaling-related terms that can tie into trafficking-regulated signaling. A minor, separate term for larval cuticle development appears less central to the core function. Overall, the dominant theme is vesicle trafficking and endocytosis.","confidence":"High","size":7,"edges":10,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0032511","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0006897","count":1},{"id":"GO:1902961","count":1}]},{"hash":"413710935159157670","title":"Unknown","description":"Top GO terms span insect cuticle development, fish lateral line development, innate immune signaling, NF-kappaB signaling, protein folding, synaptic vesicle endocytosis, and cellular senescence. This mix implies no single cohesive function or pathway tying the seven proteins together, making a specific, representative label unreliable. Therefore, Unknown.","confidence":"","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:2000510","count":1},{"id":"GO:0006457","count":1},{"id":"GO:0048488","count":1},{"id":"GO:0010204","count":1}]},{"hash":"785371888216984192","title":"Unknown","description":"Top GO terms are not listed for this cluster, so there is no functional signal to tie the proteins to a specific process. The cluster shows many edges among 7 proteins (15 edges, 14 triangles), indicating a highly interconnected module, which is often indicative of a protein complex or core interaction unit. Without GO evidence, I cannot assign a meaningful label beyond Unknown.","confidence":"","size":7,"edges":15,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[]},{"hash":"221333216358419917","title":"Membrane Transport and Ion Homeostasis","description":"The cluster shows repeated GO terms for solute transport and regulation of membrane potential (bicarbonate, fructose, oxalate transport; regulation of membrane potential; intracellular pH), suggesting a cohesive theme around transport processes and ionic balance across membranes. While several terms (cuticle development, sporulation, gastric acid secretion, sensory perception of sound, sperm capacitation) are more context-specific, the dominant signal is membrane transport. ","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0015701","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0051454","count":2}]},{"hash":"1339491822268035003","title":"Chitin degradation and inflammatory signaling","description":"The top GO terms point to chitin catabolic process and inflammatory mediator production, with positive regulation of chemokine production, plus a broader carbohydrate metabolic process. This suggests a cohesive theme where enzymes breaking down chitin intersect with immune signaling and chemokine regulation, characteristic of defense-related carbohydrate processing.","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0005975","count":2}]},{"hash":"868588657040717471","title":"ER stress and NF-\u03baB signaling","description":"These terms cluster around ER-associated protein processing and stress responses: unfolded protein response, oxidative stress, and glycosylation pathways reflect protein folding in the ER, while I-kappaB phosphorylation points to NF-\u03baB\u2013mediated inflammatory signaling activated by such stress. Some terms (magnesium transport, circulatory development) seem less connected and may reflect annotation noise.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":2},{"id":"GO:0034599","count":1},{"id":"GO:0015693","count":1},{"id":"GO:0072358","count":1},{"id":"GO:0035269","count":1}]},{"hash":"1138796272784560027","title":"ER stress response and protein folding","description":"The cluster\u2019s strongest GO signals center on endoplasmic reticulum stress and proteostasis, with terms for response to unfolded protein, ER protein folding, ERAD, and translation initiation in response to ER stress. Several other terms (developmental and structural) appear but are markedly less frequent; the ER-focused terms suggest the proteins predominantly participate in ER quality control and the unfolded protein response.","confidence":"High","size":7,"edges":17,"triangles":18,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:1905259","count":1},{"id":"GO:0006986","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0071374","count":1}]},{"hash":"1116514021115576454","title":"Larval chitin-based cuticle development","description":"Top GO term indicates larval chitin-based cuticle development, with 4 of 7 proteins annotated to this process. The cluster\u2019s connectivity (edges and triangles) supports a cohesive module likely involved in larval exoskeleton formation or remodeling. Therefore, the label captures the shared function of this group.","confidence":"High","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4}]},{"hash":"1176155518794341386","title":"Membrane Transporters for Sugars and Substrates","description":"These proteins cluster around transport across membranes for diverse substrates\u2014sugars (fructose, glucose, xylose, arabinose), nitrite, xenobiotics, and related compounds\u2014with at least one term for neurotransmitter loading into synaptic vesicles. The common thread is transporter activity rather than a single metabolic pathway, supporting a label focused on membrane transport of sugars and other substrates.","confidence":"High","size":7,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":7},{"id":"GO:1990539","count":7},{"id":"GO:0015707","count":7},{"id":"GO:0098700","count":7},{"id":"GO:0042891","count":7}]},{"hash":"44281440291312336","title":"Clathrin-mediated endocytosis and vesicle trafficking","description":"This cluster centers on endocytosis, clathrin coat assembly, vesicle cargo loading, and protein targeting to vacuoles, with additional ties to RTK signaling pathways (EGFR/PDGFR\u03b2) that are often regulated via endocytic trafficking. The terms converge on a vesicle-formation/trafficking theme, especially clathrin-dependent routes.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":1},{"id":"GO:1902961","count":1},{"id":"GO:2000588","count":1},{"id":"GO:0048268","count":1},{"id":"GO:0015032","count":1}]},{"hash":"374152701265726294","title":"Oocyte pole plasm mRNA localization and processing","description":"The dominant terms point to pole plasm localization and oskar mRNA localization, plus mRNA processing and microtubule polarization in oocytes, indicating a cohesive role in oocyte polarity and mRNA localization. A few mitochondrial terms are present but much less represented.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":4},{"id":"GO:0007318","count":4},{"id":"GO:0045451","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0008103","count":4}]},{"hash":"1877440908261236535","title":"APC/C-Driven Mitosis and Ubiquitination","description":"The top GO terms center on the mitotic cell cycle and APC/C-dependent catabolic processes, along with ubiquitination activities (K11-linked and polyubiquitination). This points to a theme of ubiquitin-mediated proteolysis regulating mitosis via the APC/C complex, with a few peripheral terms (cadmium response, signaling pathways) likely representing broader cellular roles. Overall, the cluster seems to reflect cell cycle control through ubiquitin-dependent protein degradation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0051301","count":4},{"id":"GO:2001162","count":4},{"id":"GO:0071276","count":4}]},{"hash":"355526246045401858","title":"Adrenergic GPCR-cAMP Signaling","description":"The top GO terms center on adenylate cyclase-activating GPCR signaling and activation of adenylate cyclase, i.e., the adrenergic GPCR-cAMP pathway. This is complemented by terms related to blood pressure regulation and vasoconstriction, suggesting a vascular signaling theme. Some immune-related terms appear, but the core cluster appears tied to adrenergic GPCR signaling and cAMP pathways.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0045777","count":2},{"id":"GO:0043950","count":1}]},{"hash":"1382451772099016537","title":"Unknown","description":"The listed GO terms cover a wide range of processes\u2014from regulation of signaling pathways (BMP, TGF-\u03b2/SMAD, NF-\u03baB) to vesicle trafficking and nuclear export, plus plant development (meristem identity) and even photosystem adjustments and germ-line masculinization. There isn\u2019t a single cohesive functional theme that ties these factors together, so a clear, specific label isn\u2019t justifiable. Therefore, Unknown with None. ","confidence":"","size":7,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046827","count":4},{"id":"GO:0061191","count":3},{"id":"GO:0010074","count":3},{"id":"GO:0080005","count":3},{"id":"GO:0030514","count":3}]},{"hash":"461375333098802000","title":"Neural development and cell-ECM adhesion","description":"This cluster groups proteins associated with nervous system development (substantia nigra development, CNS myelination, neural retina development) together with extracellular matrix assembly and focal adhesion regulation, suggesting a theme of neural tissue development coordinated with cell-matrix adhesion and ECM remodeling. The inclusion of a neural signaling term (serotonin uptake) supports a brain-related context, though some terms are peripheral to neural development, leading to a Moderate confidence.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051893","count":1},{"id":"GO:0042759","count":1},{"id":"GO:0085029","count":1},{"id":"GO:0022010","count":1},{"id":"GO:0030501","count":1}]},{"hash":"1874548844730096729","title":"RNA processing and translation initiation cluster","description":"This group centers on RNA maturation and translation control, with GO terms for spliceosome-mediated mRNA splicing, small-subunit processome assembly, and regulation of translational initiation, plus assembly of the eIF4F complex. The co-occurrence of these RNA processing and translation initiation terms suggests proteins here function together in RNA processing and the initiation of translation, making a cohesive RNA-centric cluster.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903586","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0006378","count":2},{"id":"GO:1900363","count":2},{"id":"GO:1905663","count":2}]},{"hash":"683849764237528097","title":"Epithelial Polarity and Tight Junction Assembly","description":"The top GO terms are dominated by establishment of epithelial cell polarity, apical/basal polarity, and bicellular tight junction assembly, pointing to a cluster of proteins involved in epithelial (and endothelial) barrier organization. A few other terms in the list (e.g., GABA secretion, osteoclast regulation, metabolism) are less central and may reflect broader multifunctionality. Overall, the theme is epithelial polarity and tight junction/border formation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":3},{"id":"GO:0045197","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0035641","count":3},{"id":"GO:0090557","count":2}]},{"hash":"436631200423165111","title":"Neural crest and cranial nerve development","description":"The terms cluster around neural development and wiring: neural crest cell migration (autonomic NS development, ventral trunk), facial/acoustic ganglion development, vestibulocochlear nerve organization, cerebellar Purkinje layer development, axon guidance and projection (positive regulation of axon extension), synapse maturation, and regulation of neuronal synaptic plasticity. There is one outlier term related to larval cuticle development that likely reflects annotation noise rather than core biology. Overall, the cluster highlights development and wiring of neural structures and sensory pathways.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0060074","count":1},{"id":"GO:1901166","count":1},{"id":"GO:1903375","count":1},{"id":"GO:0021680","count":1}]},{"hash":"1434132377356368251","title":"RNA processing and translation regulation","description":"This cluster centers on mRNA splicing, processing, and regulation of translation initiation, including spliceosome/processome components and eIF4F assembly, with additional hints from miRNA-mediated translational repression. Despite several obsolete terms, the dominant themes unify around post-transcriptional RNA metabolism and control of protein synthesis.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903586","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0006378","count":2},{"id":"GO:1900363","count":2},{"id":"GO:1905663","count":2}]},{"hash":"1885039173705282627","title":"Cytoskeletal remodeling and morphogenesis","description":"These proteins appear linked by cytoskeletal remodeling and morphogenesis. Top GO terms include filopodium assembly, dendritic spine morphogenesis, and mitotic spindle assembly, all pointing to actin/microtubule dynamics guiding membrane protrusions, cell division, and tissue morphogenesis. Additional terms about sprouting angiogenesis, mating projection growth, and trabecula morphogenesis reflect broader morphogenetic remodeling across contexts. Overall, the cluster likely represents proteins involved in reorganizing the cytoskeleton during development and cell movement.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043524","count":7},{"id":"GO:0090307","count":7},{"id":"GO:0090051","count":7},{"id":"GO:0031384","count":7},{"id":"GO:0061383","count":7}]},{"hash":"2136667697725828237","title":"Neural development and axon guidance","description":"This cluster is dominated by terms related to nervous system development, especially axon guidance and pathfinding (e.g., anterior/posterior axon guidance, olfactory bulb and peripheral nervous system development), plus cell\u2013cell adhesion and Rho signaling regulation. The common thread is proteins involved in neural development and axon navigation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048661","count":3},{"id":"GO:0010693","count":3},{"id":"GO:0048691","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0048070","count":3}]},{"hash":"1105266344767449248","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006353","count":1},{"id":"GO:0021954","count":1},{"id":"GO:0019835","count":1},{"id":"GO:0006189","count":1},{"id":"GO:0044205","count":1}]},{"hash":"1259630397174621039","title":"Unknown","description":"The cluster shows a mix of developmental processes (multicellular organism development, neuron projection development, lens fiber cell differentiation, skeletal system development) alongside immune-related terms (innate immune response, defense response to Gram-positive bacterium, regulation of activated T cell proliferation). With no coherent single function tying these terms together and including an obsolete pathway term, there isn\u2019t a clear, specific label to assign beyond Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0050773","count":2}]},{"hash":"2205371530392314287","title":"Intracellular trafficking and membrane organization","description":"This cluster centers on vesicle transport from the endoplasmic reticulum to the Golgi, organelle positioning (mitochondria distribution), and membrane lipid biosynthesis, plus a mitotic spindle component, all pointing to intracellular transport, organelle organization, and membrane biogenesis as the shared theme. While some terms touch broader regulatory roles or development, the strongest common thread is dynamic membrane trafficking and organelle coordination. ","confidence":"Medium","size":7,"edges":18,"triangles":23,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0010628","count":5},{"id":"GO:0055091","count":5},{"id":"GO:0048312","count":4},{"id":"GO:0043524","count":4}]},{"hash":"596023409515654315","title":"GPCR-cAMP Signaling and Development","description":"The cluster is enriched for GPCR-related signaling terms, including adenylate cyclase-activating adrenergic and dopamine receptor pathways, and cAMP signaling, with additional Rho signaling and several development-related terms (heart development, radial glial scaffold formation, hepatocyte apoptosis, cell cycle). This suggests a core theme around receptor-mediated signaling influencing development and cell fate, despite some broader or secondary processes represented. ","confidence":"Medium","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":7},{"id":"GO:0007266","count":7},{"id":"GO:0007049","count":7},{"id":"GO:0034497","count":7},{"id":"GO:0071880","count":7}]},{"hash":"1281174146766841303","title":"Neural development and regeneration","description":"The cluster includes GO terms tied to nervous system formation and repair, notably neurogenesis (GO:0022008), peripheral nervous system axon regeneration (GO:0014012), and positive regulation of collateral sprouting (GO:0048672). While there are additional terms related to tissue development in other organs and immune responses, the strongest and most coherent signal across the terms centers on neural development and axon regeneration, suggesting the proteins are enriched for nervous system growth and repair functions.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030277","count":3},{"id":"GO:0060068","count":3},{"id":"GO:0014012","count":3},{"id":"GO:0009615","count":3},{"id":"GO:1900016","count":3}]},{"hash":"1859393044211050165","title":"Unknown","description":"The GO terms span neural development (dendrite morphogenesis, potassium ion transport, sensory perception), broad development (multicellular organism development, tricuspid valve morphogenesis), and various transcription/signaling processes, with no clear, single functional theme tying all proteins together. Because the cluster shows mixed and weakly related functions, I cannot assign a specific, representative label.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046827","count":6},{"id":"GO:0006813","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0048813","count":6}]},{"hash":"639356568145932606","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by GO terms related to ribosome assembly, ribosome biogenesis, and both mitochondrial and cytoplasmic translation (e.g., mitochondrial translation, cytoplasmic translation, ribosome biogenesis, tRNA modification, and ribosomal subunit export). These collectively point to a core function in protein synthesis and ribosome maturation, with a few outlier terms that are less directly connected. Overall, the label reflects the prevailing theme of ribosome-related processes.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":2},{"id":"GO:0000055","count":1},{"id":"GO:0090529","count":1},{"id":"GO:0000747","count":1},{"id":"GO:1903833","count":1}]},{"hash":"2165872596527889872","title":"Developmental gene regulation and cell proliferation","description":"The Top Terms include DNA replication and DNA-templated transcription, plus several development-related processes (mesoderm formation, motor neuron axon fasciculation, mammary gland morphogenesis) and regulation of cardiac muscle cell proliferation. This suggests a theme around gene expression control during developmental contexts and associated proliferation, rather than a single specific pathway. Therefore, a label like \u201cDevelopmental gene regulation and cell proliferation\u201d is appropriate, with a Medium confidence given the mixed set of terms. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0060044","count":5},{"id":"GO:0060045","count":5},{"id":"GO:0001707","count":5}]},{"hash":"2007497744515286947","title":"DNA replication and translation regulation","description":"The cluster includes DNA replication and meiotic gene conversion terms, together with multiple post-transcriptional and translational regulation terms (mRNA deadenylation, translation, cytoplasmic translation, translational fidelity). This mix points to proteins involved in genome maintenance coupled with control of gene expression at the translation level; some developmental/behavioral annotations may reflect pleiotropy or annotation noise, but the core signal is genome-related processes and translation control.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0048701","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0035640","count":2},{"id":"GO:0006311","count":2}]},{"hash":"1373225745454634313","title":"Retroviral DNA Integration and Latency","description":"The GO terms cluster around steps in a retroviral life cycle: entry of the virus/symbiont into the host cell, integration of viral DNA into the host genome, establishment of proviral latency, and reverse transcription (RNA-templated DNA biosynthesis). Additional terms related to DNA replication/recombination and modulation of host defenses (siRNA processing, apoptosis) support a retroviral/intracellular-pathogen theme. This makes the label concise, specific, and representative of the cluster's function.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0006310","count":4}]},{"hash":"1801643628885965139","title":"Membrane biosynthesis and vesicle trafficking","description":"The top GO terms point to both sugar and lipid biosynthesis (glycogen, UDP-GlcNAc, UDP-glucose, phosphatidic acid) and membrane-associated signaling (phosphatidylinositol signaling), which underpin membrane construction and dynamics. This is complemented by processes tied to membrane architecture and movement (microvillus assembly, cell morphogenesis, mitotic cytokinesis) and vesicle trafficking regulation (GTPase activity regulation, synaptic vesicle exocytosis). Together, they suggest a coherent theme around membrane biogenesis, trafficking, and cytoskeletal remodeling governing cell surface structure and division.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":2},{"id":"GO:0006048","count":2},{"id":"GO:0006011","count":2},{"id":"GO:0032534","count":2},{"id":"GO:0006654","count":2}]},{"hash":"472770584882555140","title":"Redox regulation in male germ cell development","description":"These proteins show strong signals for redox/oxidative stress processes (response to hydrogen peroxide, hydrogen peroxide catabolic process, cellular oxidant detoxification, redox homeostasis) and, separately, terms tied to male gonad development and regulation of germ cell proliferation. The overlap suggests a coherent theme where redox balance influences male germ cell development, with some ECM/lipid biosynthesis terms likely reflecting broader tissue remodeling rather than a separate function.","confidence":"Medium","size":7,"edges":16,"triangles":17,"max_degree":6,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007252","count":3},{"id":"GO:0022417","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0042744","count":3},{"id":"GO:0045454","count":3}]},{"hash":"1320204166138921038","title":"Unknown","description":"These GO terms span nervous system development (Purkinje cell layer development, visual learning), reproductive biology (sperm capacitation, development of secondary sexual characteristics), wound-healing proliferation, glycosylation and proteoglycan biosynthesis, and acute inflammation. There is no single coherent function or pathway uniting these terms, so a stable, specific label cannot be assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0048147","count":1},{"id":"GO:0045136","count":1},{"id":"GO:0006688","count":1}]},{"hash":"746706121046446808","title":"Adrenergic and Dopaminergic GPCR Signaling","description":"This cluster centers on GPCR-mediated signaling through adrenergic and dopaminergic receptors, including adenylate cyclase/cAMP pathways and related calcium signaling, with links to cardiovascular regulation and immune cell differentiation. The convergence on adrenergic/dopaminergic signaling plus associated heart and immune processes justifies a single, specific label.","confidence":"High","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":2},{"id":"GO:0001994","count":2},{"id":"GO:0051482","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0071880","count":2}]},{"hash":"1378081014583200237","title":"Unknown","description":"The top GO terms span nuclear DNA replication and transcription termination, bone development (angiogenesis/osteoblast differentiation), mitochondrial ATP synthesis, chaperone-dependent refolding, vacuolar acidification, proteasome storage granule assembly, and even bacterial motility, with some terms obsolete. This broad mix shows no single coherent function tying the cluster together, so it is best labeled Unknown.","confidence":"","size":7,"edges":11,"triangles":6,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0006353","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0001649","count":3}]},{"hash":"230370530352305589","title":"Viral DNA integration and proviral latency","description":"The set of terms centers on viral interaction with the host genome: integration of viral DNA, DNA replication and recombination, RNA-templated DNA synthesis (reverse transcription-like), and establishment of proviral latency, along with viral/host cell entry and host manipulation (apoptosis suppression, RNAi regulation). This cohesive theme suggests a cluster driven by viral genome integration and latent persistence.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2}]},{"hash":"1923951661464106850","title":"Apoptosis and DNA damage response","description":"The top GO terms point to cell stress\u2013triggered apoptosis (including intrinsic ER-stress\u2013related apoptosis) and processing of DNA double-strand breaks, with supporting regulation by ubiquitination and neddylation that modulate chromatin dynamics and cell fate. While a few terms touch immune signaling or meiotic chromatin processes, the strongest cohesive signal is stress-induced apoptosis coupled with genome integrity maintenance, hence the label. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0043524","count":1},{"id":"GO:0050852","count":1},{"id":"GO:0000729","count":1},{"id":"GO:0031058","count":1}]},{"hash":"1394215648302527444","title":"Mitochondrial and chloroplast electron transport","description":"The top GO terms point to proton transmembrane transport and electron transport chains in both mitochondria (ubiquinol to cytochrome c; aerobic respiration) and chloroplasts (photosynthesis and photosynthetic electron transport). This suggests the cluster centers on energy production via organellar electron transport chains. Some terms like insulin signaling are peripheral, but the dominant theme is energy metabolism through electron transport.","confidence":"High","size":7,"edges":6,"triangles":4,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1902600","count":5},{"id":"GO:0006122","count":4},{"id":"GO:0015979","count":3},{"id":"GO:0051291","count":3},{"id":"GO:0009767","count":2}]},{"hash":"434110350934565664","title":"Neural development and synaptic signaling","description":"The proteins cluster around neural development and sensory system processes, including inner ear receptor cell development, innervation, and lateral geniculate nucleus development, as well as synaptic transmission (cholinergic) and synaptic plasticity (long-term potentiation) with dopamine secretion. Sodium ion transmembrane transport aligns with neuronal excitability, supporting a cohesive theme of neural connectivity and signaling, despite a few peripheral terms (amyloid-beta response, skeletal muscle growth) that are less central. ","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060119","count":7},{"id":"GO:0060384","count":7},{"id":"GO:1905920","count":7},{"id":"GO:0035725","count":7},{"id":"GO:1900273","count":7}]},{"hash":"539051404132208548","title":"Unknown","description":"The top GO terms are scattered across translation/ribosome assembly, protein modification, signaling, and metabolic/nutrient responses, coming from diverse contexts (translation machinery, ubiquitination, GPCR signaling, SREBP pathways, plant development, erythrocyte homeostasis). With no connecting edges and no clear shared function, there isn\u2019t a cohesive theme to define a specific label beyond Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060416","count":2},{"id":"GO:0046944","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0000028","count":1},{"id":"GO:0034101","count":1}]},{"hash":"1219918041481371134","title":"Chromatin Assembly and Developmental Regulation","description":"The terms point to chromatin organization (CENP-A chromatin assembly, histone H3 acetylation) while also highlighting broad developmental processes (brain and male gonad development, multicellular growth). Microtubule severing and protein oligomerization add cellular context but still fit within a theme of chromatin-regulated development. Overall, it suggests a theme of chromatin-based regulation during development rather than a single, cohesive pathway.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061641","count":3},{"id":"GO:0035435","count":3},{"id":"GO:0043966","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1225127312057016245","title":"Nematode development, fertilization, and molting","description":"The GO terms point to developmental and reproductive processes typical of nematodes, including embryonic morphogenesis, axis specification, polyspermy prevention, and molting of the cuticle, with a few general cellular processes also present. This suggests a coherent theme around nematode development and reproduction, hence the label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0048632","count":1},{"id":"GO:0007313","count":1},{"id":"GO:2000360","count":1}]},{"hash":"1592948732108706626","title":"Embryonic and Endocrine Development","description":"This cluster centers on developmental differentiation across multiple embryonic lineages (endocrine pancreas development, endocrine system development, placental/trophoblast differentiation, left-right patterning, and heart-associated EMT), with general RNA processing terms providing background support.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0000055","count":1},{"id":"GO:0000398","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0035270","count":1}]},{"hash":"986947162184010657","title":"Adrenergic GPCR Signaling with Immune Modulation","description":"This cluster centers on GPCR-driven signaling pathways such as adrenergic signaling (adenylate cyclase activation/inhibition, calcium signaling) and dopamine-related processes, with additional terms pointing to immune functions (inflammatory response, dendritic cell differentiation). The combination suggests a theme of signaling cascades modulating immune/inflammatory states, even though there are also broader cellular processes like ribosome biogenesis and kinase activation present.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032147","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0043950","count":1},{"id":"GO:0001994","count":1},{"id":"GO:0051482","count":1}]},{"hash":"519389193826478107","title":"Plant nitrosative stress signaling and carbon metabolism","description":"The top terms center on nitrosative stress response and redox signaling (response to nitrosative stress, peptidyl-cysteine S-nitrosylation, extracellular regulation of signal transduction) and copper ion response, suggesting redox signaling under stress. The additional terms point to plant-specific carbon metabolism and cell-wall biosynthesis (ethanol/sorbitol catabolism, lignin biosynthetic process), indicating these proteins may coordinate metabolic adjustments with stress responses in plants. Overall, the cluster seems to reflect plant-specific nitrosative stress signaling linked to metabolic and cell-wall processes.","confidence":"Medium","size":6,"edges":9,"triangles":5,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0043486","count":3},{"id":"GO:0032508","count":3},{"id":"GO:0006069","count":3},{"id":"GO:0051409","count":3},{"id":"GO:0006062","count":3}]},{"hash":"119058575578782045","title":"Transmembrane Sugar and Nutrient Transporters","description":"The top GO terms are dominated by various transmembrane transport processes for nutrients and other solutes: xenobiotic transmembrane transport, nitrite transport, arabinose/xylose transmembrane transport, fructose import, glucose import in response to insulin, and related metabolic activity. This suggests a cluster of membrane transporter proteins that mediate import/export of sugars and other solutes, possibly including vesicular transporter activity for neurotransmitters. The cluster shows no reported interactions (Edges 0), but the functional theme is cohesive around solute transport across membranes.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":6},{"id":"GO:1990539","count":6},{"id":"GO:0015707","count":6},{"id":"GO:0098700","count":6},{"id":"GO:0042891","count":6}]},{"hash":"1021591871896736477","title":"Oxidative Stress Response and Proteostasis","description":"The GO terms show responses to hydrogen peroxide and high light, plus regulation of ROS metabolism and heat-stress response, indicating a focus on oxidative/thermal stress and proteostasis. Protein stabilization and regulation of protein oligomerization reinforce the theme of maintaining protein function under stress; lens morphogenesis is a tissue-specific note but does not dominate the overall pattern.","confidence":"High","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042542","count":5},{"id":"GO:0009644","count":4},{"id":"GO:0032387","count":4},{"id":"GO:0007568","count":4},{"id":"GO:1900034","count":4}]},{"hash":"2041236215400703330","title":"Membrane Transporters","description":"The top GO terms cluster around transmembrane transport of ions (sodium, potassium) and small molecules (glucose, fructose, nitrite, xenobiotics), with an additional vesicular transport term, indicating proteins primarily involved in moving substances across membranes and within secretory pathways.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:1904645","count":2},{"id":"GO:0006855","count":1},{"id":"GO:1990539","count":1}]},{"hash":"359567747343717962","title":"Genome maintenance and mitochondrial quality control","description":"The top GO terms cluster around genome maintenance (DNA replication and biosynthesis) alongside mitochondrial protein handling (import into the intermembrane space, chaperone-mediated assembly), oxidative stress response, and autophagy-related processes (autophagosome maturation). A unifying theme is genome integrity coupled with mitochondrial protein quality control and turnover, including related cytoskeletal dynamics (microtubule severing). This combination suggests a related functional module rather than random co-occurrence.","confidence":"Medium","size":6,"edges":10,"triangles":7,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0071897","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0034599","count":3},{"id":"GO:0045041","count":3}]},{"hash":"1365262347845889982","title":"Retroviral genome integration and latency","description":"The top terms point strongly to retroviral life-cycle steps: genome integration, reverse transcription (RNA-templated DNA biosynthesis), DNA replication and recombination, and proviral latency within the host nucleus. While a few terms touch on general host\u2013symbiont interactions (entry, apoptosis, siRNA processing), the dominant signal is viral genome integration and establishment of latency in the host. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0006310","count":1}]},{"hash":"1911870412526647584","title":"Gene Expression and Cytoskeleton Dynamics","description":"The GO terms cluster around gene expression (ribosome biogenesis, DNA-templated transcription) and cytoskeletal/membrane processes (actin filament branching, filopodium assembly, endocytosis) with cell division signals (mitotic spindle assembly), suggesting a function related to growth, morphology changes, and trafficking.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0060017","count":2},{"id":"GO:0060041","count":2}]},{"hash":"886964575840693197","title":"Unknown","description":"The top GO terms are spread across diverse mammalian developmental and regulatory processes (heart development, ventricular differentiation, mammary gland branching, luteinization, gonad development) plus some metabolic regulation terms. There isn't a single coherent function uniting these terms for this cluster, so a broad Unknown label is appropriate.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010828","count":2},{"id":"GO:2001250","count":2},{"id":"GO:0045713","count":2},{"id":"GO:0055012","count":2},{"id":"GO:0050680","count":2}]},{"hash":"2193786867786050331","title":"Telomere maintenance and telomeric chromosome dynamics","description":"GO terms emphasize telomere maintenance (telomerase regulation, telomere capping, localization to telomeric regions, telomere DNA binding) along with chromosome segregation-related processes (spindle assembly, cohesion). ADP-ribosylation terms suggest chromatin regulation linked to telomere function. This combination supports a telomere-centric chromosomal regulatory role.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":3},{"id":"GO:0048745","count":3},{"id":"GO:0070212","count":3},{"id":"GO:0032212","count":3},{"id":"GO:1904908","count":3}]},{"hash":"1326383236567540580","title":"Plant cell cycle and transcriptional regulation","description":"The top GO terms cluster around cell division and positive regulation of transcription by RNA polymerase II, suggesting proteins in this group coordinate growth and gene expression. Plant-specific processes like anthocyanin/cyanidin biosynthesis and cell wall organization appear, but the strongest consistent signal is transcriptional control linked to the cell cycle in plants.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0045899","count":2},{"id":"GO:0030259","count":1},{"id":"GO:0006711","count":1}]},{"hash":"215519172337648810","title":"Developmental signaling and neural/heart formation","description":"This cluster is dominated by GO terms tied to development: BMP signaling regulation, neural processes (axonogenesis, forebrain cell migration, astrocyte differentiation), heart development, and collagen/fibril organization, plus adhesion. A few immune-related terms appear but do not override the clear developmental pattern. Therefore, the label reflects coordinated development of neural tissues and the heart with ECM involvement.","confidence":"Medium","size":6,"edges":12,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030513","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0021885","count":5},{"id":"GO:0007156","count":5}]},{"hash":"261413474097053654","title":"Unknown","description":"The designated GO terms describe diverse tissue development and regulatory processes (mammary involution, intestinal development, ectodermal fate, preblastoderm cell cycle, miRNA transcription) and immune and circulatory responses, with no single unifying function or pathway evident and no protein-protein interactions observed; therefore no specific cluster label can be reliably assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060056","count":1},{"id":"GO:0006954","count":1},{"id":"GO:0033600","count":1},{"id":"GO:0097152","count":1},{"id":"GO:0007347","count":1}]},{"hash":"691347985844352495","title":"Embryogenesis and vascular development","description":"This cluster\u2019s top GO terms cluster around developmental biology and tissue morphogenesis, with multiple items related to vascular development (blood circulation, endothelial cell migration) and organ/tissue differentiation (intestinal epithelial development, ectodermal fate commitment, tracheal system regulation). While some terms are more general (DNA replication) or remodeling-related (mammary gland involution, inflammatory response), the strongest shared theme appears to be embryonic/tissue development and vascular morphogenesis, suggesting proteins involved in developmental processes and circulatory patterning rather than a single, narrow function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008015","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0060056","count":1},{"id":"GO:0006954","count":1},{"id":"GO:0097152","count":1}]},{"hash":"1429117526926831072","title":"Cytoskeleton-driven morphogenesis","description":"The cluster\u2019s top GO terms cluster around cytoskeletal processes and morphogenesis (mitotic spindle assembly; filopodium and dendritic spine morphogenesis; trabecula morphogenesis), suggesting proteins that regulate cytoskeletal dynamics and cell shape changes across development and division. Some terms are niche or species-specific, but the common theme is cytoskeletal remodeling involved in morphology.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0090051","count":1},{"id":"GO:0031384","count":1},{"id":"GO:0061383","count":1}]},{"hash":"1603049144513958301","title":"Cytoskeletal remodeling and morphogenesis","description":"This cluster centers on cytoskeleton-related processes that drive cell shape changes and development, including filopodium assembly, dendritic spine morphogenesis, trabecula morphogenesis, and mitotic spindle assembly, alongside regulation of cell migration in sprouting angiogenesis and other morphogenetic growth events. The collection suggests a shared theme of cytoskeletal dynamics underpinning diverse morphogenetic outcomes across cell types, despite some loosely related or domain-specific terms. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043524","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0090051","count":5},{"id":"GO:0031384","count":5},{"id":"GO:0061383","count":5}]},{"hash":"1780402638670821463","title":"Adrenergic and Dopaminergic GPCR-cAMP Signaling","description":"The terms cluster around adenylate cyclase-activating/inhibiting GPCR pathways for adrenergic and dopaminergic receptors, highlighting cAMP signaling, vasoconstriction, and heart development, with additional links to inflammatory/immune processes like dendritic cell differentiation. This suggests a coherent theme of catecholamine receptor signaling intersecting cardiovascular and immune regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":6},{"id":"GO:0001994","count":6},{"id":"GO:0051482","count":6},{"id":"GO:0006954","count":6},{"id":"GO:0071880","count":6}]},{"hash":"1361160383950623220","title":"Unknown","description":"There are no GO terms provided for this cluster, and the sparse graph features (3 edges, 0 triangles, max degree 3) offer no clear shared function among the 6 proteins. Without functional signals, a meaningful label cannot be assigned.","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[]},{"hash":"1082906263537571681","title":"Neural Innervation and Synaptic Organization","description":"The top terms cluster around nervous system connectivity and synapse biology: innervation, postsynaptic and presynaptic membrane organization, and long-term synaptic potentiation, with supporting hints from inner ear receptor development and motor behavior. This suggests the proteins contribute to neural development, synaptic assembly, and synaptic plasticity, with some involvement in vesicle trafficking and neuron survival.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":1},{"id":"GO:0060119","count":1},{"id":"GO:0007628","count":1},{"id":"GO:0001941","count":1},{"id":"GO:1902966","count":1}]},{"hash":"1327651462842618273","title":"Ribosome Biogenesis and Translation Initiation","description":"The cluster is enriched for GO terms related to maturation of SSU-rRNA, ribosomal large subunit biogenesis, and assembly/formation of translation preinitiation complexes, as well as translation reinitiation and rRNA methylation, indicating a core function in ribosome production and initiation of translation. Some peripheral terms reference stress granule localization and ncRNA-mediated silencing, but the predominant signal points to ribosome assembly and translation initiation.","confidence":"High","size":6,"edges":11,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":3},{"id":"GO:0042273","count":2},{"id":"GO:1903608","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0031047","count":2}]},{"hash":"1503213229336680184","title":"Neural development and apoptotic regulation","description":"Although the cluster has only a few terms, the GO terms cluster around nervous system development (neuron migration, nervous system development, sympathetic nervous system development, branchiomeric skeletal muscle development) and apoptotic/survival signaling (negative regulation of neuron apoptotic process, extrinsic apoptotic signaling pathway regulation, MAPK stress signaling, STAT phosphorylation). This suggests a coherent theme of neural development with modulation of neuronal survival and stress signaling, justifying the label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":1},{"id":"GO:0001764","count":1},{"id":"GO:2001240","count":1},{"id":"GO:0048485","count":1},{"id":"GO:0031098","count":1}]},{"hash":"1463020526004803686","title":"Neuronal development and axon guidance","description":"These proteins cluster around neural development: neural crest migration, various brain/cranial nerve development processes, commissural axon guidance, and synapse maturation/plasticity, pointing to roles in nervous system patterning and axon pathfinding.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060074","count":1},{"id":"GO:1901166","count":1},{"id":"GO:1903375","count":1},{"id":"GO:0021680","count":1},{"id":"GO:0036486","count":1}]},{"hash":"1500118205313789647","title":"RNA Modification and Processing","description":"The top GO terms cluster around RNA modification and processing events\u20147-methylguanosine RNA capping, rRNA methylation, and tRNA wobble uridine modification\u2014along with related protein modification activities (deubiquitination and lysine dimethylation) and regulatory references (negative regulation of DNA binding, regulation of apoptotic process). This suggests a core theme of RNA maturation/processing with supporting post-translational modification roles, though there are some outlier terms, making the theme plausible but not exclusive. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043392","count":1},{"id":"GO:0042981","count":1},{"id":"GO:0016579","count":1},{"id":"GO:0031167","count":1},{"id":"GO:0009452","count":1}]},{"hash":"1088975678888578505","title":"Unknown","description":"The top GO terms are from multiple, unrelated biological areas (GPCR signaling and cyclic AMP, electron transport chain, blood pressure regulation, immune signaling, protein degradation pathways, cerebellar development, and lipid signaling), with no single cohesive function tying the cluster together. This suggests the proteins do not share a common, clear function at the level of GO terms provided, so a precise label is not determinable.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0045777","count":2},{"id":"GO:2000646","count":1},{"id":"GO:0070104","count":1}]},{"hash":"603217117885944604","title":"Histone acetylation\u2013linked memory and synaptic regulation","description":"This cluster is dominated by histone acetylation terms (H3/H4 acetylation) and memory-related GO terms (short-term and long-term memory), with additional cues from actin cytoskeleton dynamics, cytoskeleton-dependent transport, and presynaptic calcium regulation. Together, these suggest a theme of epigenetic regulation of gene expression underpinning memory and synaptic function, potentially coordinated with cytoskeletal remodeling. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043981","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0072520","count":2},{"id":"GO:0061087","count":2}]},{"hash":"705375751153701700","title":"Neuronal ERK/Wnt Signaling Regulation","description":"The cluster\u2019s top GO terms center on modulation of signaling pathways (ERK/MAPK cascade, Wnt signaling), serine phosphorylation, and gene expression, coupled with neuronal context features (dopamine response, excitatory postsynaptic potential, nervous system development). This suggests a cohesive role in neuronal signal transduction and transcriptional regulation.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0010628","count":4},{"id":"GO:0000186","count":4},{"id":"GO:0090263","count":4}]},{"hash":"42766949345667399","title":"Mitochondrial protein homeostasis","description":"Although there are no recorded interactions, the top GO terms point to mitochondria-related processes: assembly of the mitochondrial ribosome and protein ubiquitination, which together suggest maintenance of mitochondrial protein synthesis and turnover. This hints at a broader theme of mitochondrial protein homeostasis and quality control.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061668","count":1},{"id":"GO:0016567","count":1}]},{"hash":"652091479327064191","title":"Unknown","description":"The cluster has no GO terms and no detected interactions, providing no shared functional signal to assign a specific label. ReCIPE re-added proteins offer no clear biological theme, so no definitive naming is possible.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"158281705035515195","title":"Viral DNA integration and proviral latency","description":"The top GO terms cluster around DNA recombination, replication, and DNA integration, plus explicit terms for viral penetration into the host nucleus and establishment of integrated proviral latency, indicating processes by which viral genomes integrate and persist in host cells. Additional terms related to host-symbiont interactions and modulation of RNAi processing suggest associated host\u2013pathogen dynamics. Overall, this label reflects viral genome integration and latency with related host responses.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0006260","count":4},{"id":"GO:0090502","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0015074","count":3}]},{"hash":"351390054348614653","title":"Unknown","description":"The terms span divergent areas including insect cuticle development, body morphogenesis, enamel formation, and various immune and coagulation processes, with no clear single function tying the proteins together and no edges linking them. This heterogeneity makes it infeasible to assign a coherent, representative label.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":2},{"id":"GO:0010171","count":2},{"id":"GO:1902947","count":1},{"id":"GO:0097186","count":1},{"id":"GO:0044537","count":1}]},{"hash":"1612943094783821332","title":"Larval chitin-based cuticle development","description":"Top terms indicate a focus on chitin-based cuticle development (including larval cuticle) and body morphogenesis, suggesting proteins involved in forming the larval exoskeleton and shaping body form. The theme is cohesive and specific to larval cuticle formation, making this a representative label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040003","count":2},{"id":"GO:0010171","count":2},{"id":"GO:0008363","count":1}]},{"hash":"1368106674643078361","title":"Immune signaling and ubiquitin regulation","description":"This cluster is enriched for terms related to immune signaling (T cell receptor signaling, C-type lectin receptor signaling) and antiviral responses, along with ubiquitin pathway regulation (deubiquitination and regulation of ubiquitin ligase activity). The combination suggests a theme where immune signaling is modulated by ubiquitin-related processes, with hints of broader defense responses (including plant immunity and viral interactions) reflected in the GO terms. ","confidence":"Medium","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0050852","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0002223","count":3},{"id":"GO:0006521","count":3}]},{"hash":"1502759617126541962","title":"Ribosome Biogenesis and rRNA Processing","description":"This cluster is strongly driven by GO terms for rRNA maturation (5.8S, SSU, LSU) and ribosomal large subunit biogenesis, which together point to nucleolar ribosome assembly and RNA processing functions. Other terms like ubiquitination and embryonic development are present but less central, making the ribosome biogenesis theme the most representative. ","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0048568","count":2}]},{"hash":"336423659764455082","title":"MHC-mediated antigen processing and presentation","description":"The top terms prominently point to antigen processing and presentation via MHC class I and II, along with a defense response to bacteria, which together indicate an immune presentation function. Other terms appear more related to RNA processing or regulatory noise, but the core signal is MHC-associated antigen presentation, suggesting proteins in this cluster contribute to immune surveillance. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":1},{"id":"GO:0042590","count":1},{"id":"GO:0019886","count":1},{"id":"GO:1900426","count":1},{"id":"GO:1903586","count":1}]},{"hash":"645752448411921481","title":"Adrenergic and Dopaminergic GPCR Signaling in Heart and Immunity","description":"The cluster's terms center on GPCR signaling that modulates cAMP via adrenergic and dopaminergic receptors, including adenylate cyclase activation/inhibition and norepinephrine/epinephrine\u2013mediated vasoconstriction, plus heart development. Immune-related terms (inflammatory response, dendritic cell differentiation) suggest modulation of immunity by these neuromodulatory pathways, making a cohesive theme of cardiovascular/immune signaling.","confidence":"High","size":6,"edges":8,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":3},{"id":"GO:0001994","count":3},{"id":"GO:0051482","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0071880","count":3}]},{"hash":"213818388542320355","title":"Mitosis and vesicle trafficking","description":"The top GO terms cluster around mitotic processes (cell division, cell cycle, exit from mitosis, mitotic spindle assembly, cytokinesis-related septum digestion) and membrane trafficking events (multivesicular body assembly/sorting). This suggests a functional group coordinating chromosome segregation with vesicle trafficking during division, with a touch of autophagy-related membrane dynamics.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":2},{"id":"GO:1902902","count":2},{"id":"GO:0010458","count":2},{"id":"GO:0000920","count":2}]},{"hash":"1880057552964260158","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":6,"triangles":2,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0071049","count":5},{"id":"GO:1900050","count":5},{"id":"GO:1902775","count":5},{"id":"GO:1990416","count":5},{"id":"GO:0000480","count":5}]},{"hash":"1399193590579590663","title":"Plant cell wall polysaccharide biosynthesis","description":"This cluster is dominated by GO terms for plant cell wall processes and polysaccharide biosynthesis (e.g., cell wall organization, plant-type secondary cell wall biogenesis, homogalacturonan and glucuronoxylan biosynthesis, and mucilage biosynthesis), with related sugar metabolism and glycosylation terms. Together they point to proteins involved in building and modifying plant cell wall polysaccharides and their glycosylation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":1},{"id":"GO:0016266","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0010289","count":1},{"id":"GO:0010192","count":1}]},{"hash":"261552571038053630","title":"RNA modification and ribosome biogenesis","description":"The top terms cluster around RNA modification (pseudouridine synthesis on rRNA and tRNA), translation, and ribosome biogenesis, pointing to roles in RNA modification and ribosome assembly, with supportive signals for translational fidelity and initiation control; occasional stress and metabolic terms appear less central.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000455","count":2},{"id":"GO:1990145","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0031119","count":1}]},{"hash":"566260299138606240","title":"Cell Growth and Cycle Regulation","description":"These terms collectively point to controls of cell proliferation and division, with an additional link to cytoskeletal organization (microtubule anchoring). The cluster likely comprises proteins that modulate growth and cell cycle progression rather than a single specialized pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":1},{"id":"GO:2000495","count":1},{"id":"GO:0002318","count":1},{"id":"GO:0034453","count":1},{"id":"GO:0030307","count":1}]},{"hash":"639076552105418367","title":"Adrenergic and Dopaminergic GPCR Signaling","description":"The cluster is dominated by GO terms linking GPCR signaling that modulates adenylate cyclase and cAMP, specifically through adrenergic and dopaminergic receptors (and related pathways). The presence of inflammatory response and heart development terms suggests the proteins participate in broader neuroimmune and cardiovascular signaling cross-talk anchored by GPCR-cAMP signaling, making this naming representative of the shared function.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0051482","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0071880","count":4}]},{"hash":"2270831990279878984","title":"Fungal recognition and immune receptor signaling","description":"Most terms point to innate immune sensing of fungi (cellular response to molecule of fungal origin; stimulatory C-type lectin receptor signaling) and downstream immune signaling pathways (T cell receptor signaling, Fc-gamma and Fc-epsilon receptor signaling, phagocytosis recognition). Some terms like heart development and lymph vessel morphogenesis are less connected and likely incidental. Overall, the cluster centers on fungal recognition via C-type lectin receptors and related immune signaling.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":3},{"id":"GO:0002223","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1036353837179865829","title":"Chromatin organization and histone modification","description":"The top GO terms center on chromatin-related processes\u2014nucleosome assembly, heterochromatin organization, and localization of proteins to chromatin\u2014along with histone methylation marks (H3-K27, H3-K4), albeit with obsolete annotations. This pattern indicates a cluster of proteins involved in regulating chromatin structure and histone modification.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":6},{"id":"GO:0098532","count":6},{"id":"GO:0070828","count":6},{"id":"GO:0071169","count":6},{"id":"GO:0080182","count":6}]},{"hash":"236251014090274220","title":"Neuronal Synaptic Transmission and Plasticity","description":"This cluster features GO terms tied to synaptic signaling and neural plasticity\u2014positive/negative regulation of synaptic transmission, short-term plasticity, neuromuscular transmission, and long-term memory\u2014pointing to neuronal communication as the core function. Some development-related terms (lateral line and cerebellar differentiation) suggest broader nervous system development signals, while other terms (metabolic responses) may be incidental annotations. Overall, the dominant theme is neuronal transmission and plasticity.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050806","count":1},{"id":"GO:0048915","count":1},{"id":"GO:0048899","count":1},{"id":"GO:0048172","count":1},{"id":"GO:0051967","count":1}]},{"hash":"288988053103476962","title":"P450-Mediated Xenobiotic and Steroid Metabolism","description":"The top GO terms cluster around cytochrome P450\u2013driven oxidation pathways (omega-hydroxylase P450 pathway), xenobiotic degradation (camphor, carbazole), and androgen/steroid metabolism, with a note on ozone response. Together these indicate a coherent theme of detoxification and steroid processing via P450 enzymes, despite a few miscellaneous annotations. Confidence: High","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":5},{"id":"GO:0090350","count":5},{"id":"GO:0019383","count":5},{"id":"GO:0097267","count":5},{"id":"GO:0046232","count":5}]},{"hash":"140269861481582955","title":"Multilineage differentiation and vascular morphogenesis","description":"The cluster\u2019s top GO terms center on differentiation across multiple tissues (mesenchymal, endocardial, endothelial, photoreceptor, metanephric kidney) and on vascular morphogenesis, including both positive and negative regulation and related apoptosis, suggesting a theme of developmental regulation across lineages with a vascular emphasis.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:2000741","count":4},{"id":"GO:0046533","count":4},{"id":"GO:0060956","count":4},{"id":"GO:1902262","count":4},{"id":"GO:0072233","count":3}]},{"hash":"1069065306511879715","title":"Larval chitin-based cuticle development","description":"This cluster is named for the single GO term present: larval chitin-based cuticle development (GO:0008363), suggesting the proteins share a function in larval cuticle formation. The lack of edges or additional terms provides minimal context beyond this specific developmental process.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"1213192923159076251","title":"Neural development and chromatin remodeling","description":"The top GO terms cluster around embryonic neural development processes (anterior neuropore closure, neural fold formation, neural development-related habituation) and synaptic assembly at neuromuscular junctions, with chromatin remodeling indicating gene regulation during development. A cardiac fate term appears but most signals point to neural-developmental and regulatory processes, suggesting a developmental-biology theme with emphasis on neural aspects.","confidence":"Low","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021506","count":1},{"id":"GO:0060912","count":1},{"id":"GO:0045887","count":1},{"id":"GO:0046959","count":1},{"id":"GO:0001842","count":1}]},{"hash":"1759486263382717559","title":"Angiogenesis and vascular morphogenesis","description":"The cluster is dominated by GO terms tied to blood vessel formation and remodeling (positive regulation of angiogenesis; apoptotic process involved in blood vessel morphogenesis; regulation of systemic arterial blood pressure by atrial natriuretic peptide), indicating a vascular development/signaling theme. Immune (complement activation) and transcription regulation terms appear as secondary associations and do not alter the primary vascular focus.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071340","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0003050","count":2},{"id":"GO:0001867","count":2},{"id":"GO:1902262","count":2}]},{"hash":"485534466235237460","title":"Vertebrate embryonic development","description":"The most represented GO terms describe various aspects of embryonic organogenesis and morphogenesis across neural, craniofacial, and cardiac lineages (palate, brain, forebrain, glial differentiation, cochlea, heart). This pattern points to a cohesive theme of vertebrate development rather than a single pathway, justifying a label of Vertebrate embryonic development.","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":4},{"id":"GO:0043524","count":3},{"id":"GO:0021985","count":3},{"id":"GO:0021846","count":3},{"id":"GO:0010001","count":3}]},{"hash":"232192985584029395","title":"Unknown","description":"The terms span immune/stress responses (response to lipopolysaccharide; response to toxic substance), protein turnover (proteolysis), metabolism (thiamine biosynthetic process; various catabolic processes), and development terms, with several obsolete annotations. The lack of a single, coherent function across the proteins and the absence of edges in the network suggest there is no well-defined cluster-wide theme.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0009636","count":1},{"id":"GO:2000648","count":1}]},{"hash":"2285271655598859737","title":"Immune Cell Differentiation Regulation","description":"The cluster centers on regulation of immune cell development and lineage decisions, with GO terms for positive dendritic cell differentiation, pro-T cell differentiation, and memory T cell differentiation, and negative regulation of mast cell cytokine production. Negative regulation of protein ubiquitination also hints at signaling modulation. A couple of terms for plant tropisms appear unrelated and likely represent noise; overall the dominant signal points to immune cell differentiation control.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":3},{"id":"GO:1900477","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0043380","count":2},{"id":"GO:0032764","count":2}]},{"hash":"1337695490128566260","title":"Neural development and brain metabolism","description":"The top GO terms point to neural development (brain segmentation, olfactory bulb interneuron development, collateral axon sprouting) and neural signaling/differentiation (DNA-templated transcription). A subset of terms reflects metabolic/synthetic processes (fatty acid homeostasis, biotin biosynthesis, porphyrin biosynthesis) that could be active in brain tissue or represent general metabolism. Overall, the most coherent theme is neural development with supporting metabolic context, yielding a moderate confidence in the label.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035284","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0055089","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0006782","count":2}]},{"hash":"779443505110049548","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0031440","count":1},{"id":"GO:0045899","count":1},{"id":"GO:0042797","count":1}]},{"hash":"197678896369096081","title":"Transcription initiation and chromatin remodeling","description":"This cluster is dominated by GO terms tied to transcription initiation and chromatin regulation, including DNA-templated transcription initiation, RNA polymerase II preinitiation complex assembly, and transcription initiation-coupled chromatin remodeling. A related signal is beta-catenin-TCF complex assembly, also involved in transcriptional control, with ancillary chromatin-associated processes like histone acetylation. A few terms touch on DNA maintenance (replication fork processing, telomere capping), but the overall theme remains nuclear transcription and chromatin regulation.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006352","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0051123","count":2},{"id":"GO:0043966","count":2},{"id":"GO:1904837","count":1}]},{"hash":"289021653197368823","title":"Mitochondrial energy metabolism and redox homeostasis","description":"Top GO terms center on mitochondrial electron transport and redox balance, with multiple metabolism-related processes (lipoate, thiamine, THF, uracil/thymidine catabolism) that are associated with mitochondrial function. This suggests a cohesive theme of energy production and redox regulation, despite a few peripheral catabolic terms. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0019383","count":1}]},{"hash":"221077320455749000","title":"Unknown","description":"The top terms are heterogeneous, spanning ubiquitination, nuclear RNA processing, chromatin remodeling, mitochondrial ribosome assembly, neuronal signaling, and stress responses, with no clear single function tying the cluster together.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0071049","count":2},{"id":"GO:1900050","count":2},{"id":"GO:0031508","count":2},{"id":"GO:1902775","count":2}]},{"hash":"555711246303373309","title":"Ribosome biogenesis and RNA modification","description":"The cluster shows strong signals for ribosome assembly and RNA modification processes (rRNA methylation, tRNA wobble modification, and various methylations) indicating a core role in ribosome maturation and translation-related RNA processing. Some plant-specific terms such as chlorophyll biosynthesis and nodulation appear as outliers, possibly reflecting broader plastid gene expression or annotation breadth rather than a single cohesive function.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":1},{"id":"GO:0018027","count":1},{"id":"GO:0036068","count":1},{"id":"GO:1901052","count":1},{"id":"GO:0002098","count":1}]},{"hash":"1667836866691904293","title":"Axon guidance and synapse development","description":"Most terms describe neural development, especially axon extension and guidance, commissural and sympathetic neuron projection guidance, neural crest migration, and synapse assembly/maturation, plus nerve structural organization. These together point to a function in establishing neuronal connections and nerve architecture, with a minor outlier term for photosynthesis. ","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048846","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0060074","count":2},{"id":"GO:0036486","count":2},{"id":"GO:0021649","count":2}]},{"hash":"1336354562935665956","title":"Unknown","description":"The GO terms are highly diverse, including proteolysis regulation, mitochondrial inner membrane organization, ERAD, cadherin-mediated adhesion, extracellular matrix disassembly, lipid localization, excretion, and dopaminergic synaptic transmission, with no clear single functional theme tying the proteins together.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045861","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0007007","count":2},{"id":"GO:0052547","count":2},{"id":"GO:2000049","count":2}]},{"hash":"1226241656555310049","title":"Larval chitin-based cuticle development","description":"The cluster\u2019s top GO term is larval chitin-based cuticle development, indicating proteins likely involved in forming or regulating the larval cuticle. Although only 2 of the 5 proteins are annotated with this term, this term represents the most characteristic shared function among the cluster\u2019s members, pointing to a cohesive role in cuticle biology.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2}]},{"hash":"101169701372833792","title":"Unknown","description":"Top GO terms suggest diverse roles: placenta and heart development, multicellular organism development, sensory/visual perception, responses to drugs or muscle activity, and signaling pathways (ABA-activated signaling and protein kinase activity regulation). The lack of a unifying process or molecular function, plus zero edges, indicates this set of proteins does not form a coherent functional cluster. Therefore Unknown with None confidence.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":3},{"id":"GO:0014850","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1785539518887443877","title":"Adrenergic GPCR\u2013cAMP signaling for vascular regulation","description":"This cluster is dominated by GO terms related to adenylate cyclase-activating GPCR signaling pathways, including adrenergic receptor signaling and norepinephrine-epinephrine\u2013induced vasoconstriction, which ties to blood pressure regulation and calcium/cAMP signaling. While there are additional terms like inflammatory response and electron transport chain that hint at broader cellular processes, the core theme links GPCR-mediated adrenergic signaling to vascular control. Therefore, the label reflects the most representative function of the cluster.","confidence":"Medium","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":5},{"id":"GO:0022900","count":5},{"id":"GO:0045777","count":5},{"id":"GO:0043950","count":4},{"id":"GO:0001994","count":4}]},{"hash":"619937000522396714","title":"Craniofacial skeletal and reproductive development","description":"GO terms point to developmental processes in skeletal/craniofacial structures (skeletal system development, muscle cell development, roof of mouth development) and reproductive systems (ovarian follicle development, cellular response to gonadotropin-releasing hormone), suggesting a theme of broad developmental pathways spanning these systems, with some regulatory controls.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043392","count":3},{"id":"GO:0007620","count":3},{"id":"GO:0048747","count":3},{"id":"GO:2000354","count":3},{"id":"GO:0001501","count":3}]},{"hash":"2051699113843597888","title":"Cell Cycle Checkpoint and Stress Response","description":"The cluster centers on cell cycle control and stress signaling: terms include regulation of the cell cycle and traversing start control point of mitotic cell cycle, alongside DNA damage response and stress-related processes (UV-C, hypoxia). Transcription regulation and chromatin remodeling terms further support a regulatory module driving cell-cycle decisions under stress. A couple of development terms appear incidental, but the dominant theme is cell-cycle regulation coupled to stress responses.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0098976","count":1},{"id":"GO:0007089","count":1},{"id":"GO:0071494","count":1},{"id":"GO:0071456","count":1}]},{"hash":"479493547995428897","title":"Larval chitin-based cuticle development","description":"This cluster is named for the strongest shared function among its members, GO:0008363, which denotes larval chitin-based cuticle development. The presence of five proteins with this term suggests a cohesive group involved in the formation or remodeling of the larval exoskeleton made of chitin. The modest connectivity (Edges 7, Triangles 4) supports a focused, development-related module. ","confidence":"High","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5}]},{"hash":"1379524408157104619","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071031","count":1},{"id":"GO:0071030","count":1},{"id":"GO:0000460","count":1},{"id":"GO:0071039","count":1},{"id":"GO:0032760","count":1}]},{"hash":"1028994432232954922","title":"Chromatin organization and nucleosome assembly","description":"The top GO terms are dominated by chromatin-related processes: heterochromatin organization, nucleosome assembly, nucleosome positioning, and histone modification pathways (even though a couple are marked obsolete). The cluster appears to center on chromatin structure regulation and the targeting/localization of proteins to chromatin, which ties together nucleosome dynamics and modifications that influence chromatin state and nucleus architecture.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":5},{"id":"GO:0098532","count":5},{"id":"GO:0070828","count":5},{"id":"GO:0071169","count":5},{"id":"GO:0080182","count":5}]},{"hash":"868828065711480338","title":"Unknown","description":"The GO terms are spread across plant hormone signaling (cytokinin and auxin), development (root meristem, lung saccule, skeletal muscle), nuclear processes (telomerase assembly, glucocorticoid signaling), and hypoxia response, with no single dominant function tying the proteins together. This makes a precise, representative label uncertain.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0080037","count":1},{"id":"GO:1905323","count":1},{"id":"GO:0045201","count":1},{"id":"GO:0048642","count":1},{"id":"GO:2000012","count":1}]},{"hash":"1198557361355432651","title":"Membrane nutrient and ion transporters","description":"The GO terms point to various transmembrane transport activities for small molecules and ions (glucose, myo-inositol, biotin, pantothenate, sodium ions), suggesting a cluster of membrane transport proteins. Some terms are unrelated (development, mRNA processing), but the dominant pattern is transport across the plasma membrane, indicating nutrient/ion transporter function. Because the cluster is small and shows mixed signals beyond transport, the label is plausible but not strongly definitive.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046944","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0015878","count":1},{"id":"GO:0015887","count":1}]},{"hash":"1027862368853498178","title":"RNA Pol II Transcription and Chromatin Modification","description":"Most GO terms cluster around transcription by RNA polymerase II and regulation of chromatin, including RNA polymerase II preinitiation complex assembly, transcription by RNA Pol II, histone deubiquitination, and histone H3 acetylation. This suggests a cohesive role in transcriptional control and chromatin remodeling for the proteins in this cluster, with a few outliers related to other processes likely reflecting annotation noise. Overall, the label captures the dominant functional theme of the cluster.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0016578","count":1},{"id":"GO:0001403","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0043966","count":1}]},{"hash":"1730208091173719232","title":"Unknown","description":"The GO terms span very diverse biological areas, including mitochondrial electron transport, cuticle development, body morphogenesis, spinal cord development, mitotic M phase, tRNA modification, sulfur metabolism, and various regulatory processes. There is no coherent, single function tying these terms together, suggesting the cluster does not have a clear shared theme beyond being a mix of unrelated processes.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0010171","count":1},{"id":"GO:0021510","count":1},{"id":"GO:0000087","count":1}]},{"hash":"1083857316612297229","title":"Membrane transporters for sugars and xenobiotics","description":"These proteins group around transmembrane transport activities, including sugar import (fructose, glucose, xylose, arabinose), xenobiotics, and nitrite transport, with a vesicular transporter role for neurotransmitter loading. The common thread is membrane transport of diverse substrates across biological membranes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:1990539","count":5},{"id":"GO:0015707","count":5},{"id":"GO:0098700","count":5},{"id":"GO:0042891","count":5}]},{"hash":"398346188133095703","title":"Developmental morphogenesis and signaling","description":"This cluster centers on developmental morphogenesis terms (wing disc morphogenesis, neural tube formation, pole plasm assembly, photoreceptor development) and on signaling pathways (JAK-STAT, growth hormone receptor signaling), suggesting proteins involved in developmental patterning regulated by receptor signaling. Some terms (like T cell receptor recombination) are less clearly connected, but the dominant theme is development and signaling. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007472","count":2},{"id":"GO:0001841","count":2},{"id":"GO:0033153","count":2},{"id":"GO:0060396","count":1},{"id":"GO:0007259","count":1}]},{"hash":"1205320880506983531","title":"Purine nucleotide metabolism","description":"The top GO terms show a clear emphasis on purine nucleotide processes (AMP salvage, nucleotide phosphorylation, ADP/CDP biosynthesis, and purine ribonucleotide interconversion), suggesting the cluster is mainly about purine nucleotide generation and recycling. DNA repair is also present, which can relate to nucleotide turnover, but the liver and brain development terms may reflect ancillary annotations or multi-function roles. Overall, the main theme is purine nucleotide metabolism with a secondary connection to DNA maintenance.","confidence":"Medium","size":5,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0044209","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0046041","count":2},{"id":"GO:0046940","count":2},{"id":"GO:0001889","count":2}]},{"hash":"873077473757594363","title":"Retroviral entry and proviral latency","description":"The GO terms point to a retroviral life cycle: viral entry into the host nucleus, reverse transcription (RNA-templated DNA biosynthesis), DNA integration, and proviral latency establishment, with DNA replication/recombination as core processes. Additional terms about intracellular symbiont entry and host apoptosis modulation reinforce the intracellular pathogen/virus theme. This combination supports a cohesive label around retroviral replication and latency.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0006310","count":4}]},{"hash":"328260172461395329","title":"Unknown","description":"The GO terms are scattered across sensory perception (taste), lipid metabolism (retinol, fatty acids, lipoprotein processes), and epithelial/eye development (retina morphogenesis, gastrointestinal epithelium maintenance), with no single clear function tying all proteins together. This mix makes it hard to assign a coherent, specific cluster label, so I\u2019m labeling it Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050909","count":3},{"id":"GO:0050872","count":2},{"id":"GO:0021846","count":2},{"id":"GO:2001245","count":2},{"id":"GO:0060588","count":2}]},{"hash":"1819979792840569745","title":"Unknown","description":"The GO terms are highly diverse (angiogenesis, caffeine response, flagellated sperm motility, jasmonic acid biosynthesis, cell cycle, heart signaling, vasopressin secretion, neuronal differentiation, apoptosis, and protein ADP-ribosylation). There is no single shared function or pathway across the cluster, and no network edges link the proteins, so a coherent label cannot be determined.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":1},{"id":"GO:0071313","count":1},{"id":"GO:0030317","count":1},{"id":"GO:0080141","count":1},{"id":"GO:0007049","count":1}]},{"hash":"2091967583571274578","title":"Cell Cycle and Developmental Processes","description":"The cluster includes GO terms related to cell cycle transitions (G1/S and G2/M), DNA replication and repair, and development-related events such as myoblast fusion, axonogenesis, and excitatory synaptic activity. While one term (abscisic acid-activated signaling) is plant-specific and may be an outlier, the core signals point to proliferation and differentiation processes as a coherent theme.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000082","count":4},{"id":"GO:0009738","count":4},{"id":"GO:0007520","count":4},{"id":"GO:0043065","count":4},{"id":"GO:0006281","count":4}]},{"hash":"1534012888871882067","title":"Germinal center B and T cell regulation","description":"The GO terms center on B cell homeostasis, T helper and T follicular helper differentiation, and germinal center formation, with supporting roles in apoptosis regulation, TNF signaling, and chemokine production\u2014indicating a cohesive function in adaptive immune regulation within germinal centers.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001782","count":2},{"id":"GO:0045623","count":2},{"id":"GO:0046621","count":2},{"id":"GO:0042981","count":2},{"id":"GO:0061470","count":2}]},{"hash":"119765731444245455","title":"Unknown","description":"The GO terms span very diverse processes (proteostasis, cell cycle/chromatin regulation, meiotic DNA repair, lymphangiogenesis, metabolism, lipid A biosynthesis) with no single cohesive theme, so a meaningful specific label cannot be assigned.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006986","count":5},{"id":"GO:1905213","count":5},{"id":"GO:1990918","count":5},{"id":"GO:0001946","count":5},{"id":"GO:0035562","count":5}]},{"hash":"1780490976806482721","title":"Immune Activation Signaling","description":"The GO terms are dominated by innate immune signaling and leukocyte activation (stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, phagocytosis recognition, basophil activation, NK cell chemotaxis regulation), plus related immune processes. There are also a few development-related terms (lymph vessel morphogenesis, cartilage condensation, metanephric limb development), suggesting a cluster centered on immune signaling with some developmental associations rather than a single cohesive pathway. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":1},{"id":"GO:0090403","count":1},{"id":"GO:0002223","count":1},{"id":"GO:0006910","count":1},{"id":"GO:0038094","count":1}]},{"hash":"1871813994497403422","title":"Mitotic Chromosome Segregation and Spindle Assembly","description":"The strongest signals are mitosis-related: mitotic sister chromatid segregation and mitotic spindle assembly appear among the top GO terms, suggesting the proteins collectively participate in mitotic processes. The other terms (GTPase regulation, ubiquitination, GPCR signaling, nutrient response, etc.) may reflect broader regulatory roles or annotation noise in a small cluster. Overall, the dominant theme points to mitosis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000070","count":3},{"id":"GO:0000209","count":2},{"id":"GO:0007200","count":2}]},{"hash":"1155175342175488442","title":"Signaling and Morphogenesis","description":"The cluster includes multiple GO terms across signaling pathways (Fc receptor mediated inhibitory signaling, insulin-like growth factor receptor signaling, angiotensin-activated signaling), cytoskeletal/membrane remodeling (filopodium assembly, plasma membrane tubulation), and developmental processes (luteinization, animal organ morphogenesis, regulation of Rho signaling), suggesting proteins involved in signaling-driven morphogenesis rather than a single pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002774","count":1},{"id":"GO:0097320","count":1},{"id":"GO:0001553","count":1},{"id":"GO:0086098","count":1},{"id":"GO:1903348","count":1}]},{"hash":"1390395927914163280","title":"Unknown","description":"The cluster has only two divergent GO terms, one about female pregnancy and one obsolete RNA processing term, offering no shared functional theme across the proteins. The lack of a coherent signal (and the obsolete term) makes it impossible to assign a meaningful, specific label.","confidence":"","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007565","count":1},{"id":"GO:0090502","count":1}]},{"hash":"675846107938358746","title":"Unknown","description":"The top GO terms span immune signaling (dsRNA, TNF), metabolic and stress responses (glucose stimulus, ischemia), ion transport and membrane potential (Mg2+, K+ transport; resting potential), and neuronal signaling (glutamate reuptake), plus pigment granule dynamics. There isn\u2019t a single, cohesive biological process tying all terms together for these proteins, so a specific, representative label isn\u2019t apparent.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0043330","count":3},{"id":"GO:0015693","count":2},{"id":"GO:0060075","count":2},{"id":"GO:0002931","count":2}]},{"hash":"538567382324533003","title":"Unknown","description":"The top GO terms cover a wide and disjoint set of processes\u2014from response to cocaine and amines, to cell morphogenesis, to several biosynthetic and RNA-modification activities\u2014showing no coherent shared function. The absence of edges also argues against a connected functional module. Therefore there is no clear thematic label beyond Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0000902","count":2},{"id":"GO:0032434","count":1},{"id":"GO:0009788","count":1},{"id":"GO:0019505","count":1}]},{"hash":"1882706520130920810","title":"Neural development and glial differentiation","description":"Several top GO terms point to neural and glial development (glial cell differentiation, commissural neuron axon guidance) and embryo development, with related signaling from the Wnt/calcium pathway and morphogenesis processes (e.g., dorsal trunk growth). The cluster thus seems to reflect proteins involved in early neural patterning and glial formation, tied together by developmental signaling. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010001","count":1},{"id":"GO:0009790","count":1},{"id":"GO:0035024","count":1},{"id":"GO:0071456","count":1},{"id":"GO:0071679","count":1}]},{"hash":"2235991894151197454","title":"Unknown","description":"The Top Terms include tRNA aminoacylation (translation) and a variety of biosynthetic processes across different organisms (mycothiol, ectoine, fatty acids, verruculogen, phenylpropanoids). The lack of a cohesive, shared function across these terms makes it impossible to assign a specific, representative label to this cluster.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006431","count":1},{"id":"GO:0006423","count":1},{"id":"GO:0006429","count":1},{"id":"GO:0010125","count":1},{"id":"GO:0001561","count":1}]},{"hash":"2017600602386746500","title":"Diverse membrane transporters","description":"GO terms indicate transmembrane transport of various substrates (nitrate/nitrite, galactose, sodium, phosphate, vitamins, xenobiotics) and neurotransmitter loading, pointing to a cluster of diverse membrane transport proteins.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0015757","count":1},{"id":"GO:0015706","count":1},{"id":"GO:0035725","count":1}]},{"hash":"2192798656581765597","title":"Unknown","description":"The terms span diverse processes (unfolded protein response, meiotic DNA repair, lymphangiogenesis, lipid A biosynthesis, AMP catabolism, and chromatin/cell-cycle regulation) with no clear shared function or dominant pathway, so there is no coherent theme to assign a specific label. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":1},{"id":"GO:1905213","count":1},{"id":"GO:1990918","count":1},{"id":"GO:0001946","count":1},{"id":"GO:0035562","count":1}]},{"hash":"1028594094541607357","title":"Actin-driven endocytosis and cell polarity","description":"The top GO terms converge on actin cytoskeleton dynamics (Arp2/3-mediated nucleation, actin cortical patches), endocytosis, and establishment/maintenance of cell polarity and cell shape, suggesting a functional cluster centered on actin-driven membrane trafficking and polarity cues. The other terms about dermatan sulfate proteoglycan and xylan catabolism appear as outliers, so the core signal is actin-related processes rather than a single metabolic pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030209","count":1},{"id":"GO:0045493","count":1},{"id":"GO:0006897","count":1},{"id":"GO:0051666","count":1},{"id":"GO:0051654","count":1}]},{"hash":"1005503192710972133","title":"Organogenesis and Developmental Signaling","description":"This cluster includes GO terms tied to development and organ formation across diverse systems\u2014stomatal development, cardiac and vascular morphogenesis, hair cycle regulation, pancreatic cell fate, and Notch signaling\u2014suggesting a shared theme of developmental signaling across tissues. Some terms (e.g., SREBP pathway) are more metabolic, but the dominant pattern is development-related processes.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010374","count":4},{"id":"GO:0045668","count":4},{"id":"GO:0032933","count":4},{"id":"GO:0035910","count":4},{"id":"GO:1900402","count":4}]},{"hash":"2239036287359975529","title":"Lymphocyte differentiation and germinal center formation","description":"This cluster\u2019s top GO terms are dominated by immune-related processes: positive regulation of dendritic cell differentiation, positive regulation of pro-T cell differentiation, regulation of memory T cell differentiation, germinal center formation, negative regulation of mast cell cytokine production, and negative regulation of isotype switching to IgE. Together they suggest a common theme of adaptive immune cell development and germinal center\u2013associated functions. A few terms (phototropism, gravitropism, left/right pattern formation) appear discordant or non-specific and may reflect annotation artifacts rather than true functional coherence. Overall, the cluster likely represents lymphocyte differentiation and germinal center activity.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048294","count":3},{"id":"GO:0060972","count":3},{"id":"GO:1900477","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0043380","count":2}]},{"hash":"980654281079945906","title":"Unknown","description":"The GO terms for this cluster are highly diverse, including spinal cord development, mitotic M phase, various tRNA modification processes, sulfur metabolism, redox homeostasis, and cofactor biosynthesis, plus a few signaling and growth-regulation terms. There is no single coherent function or pathway that ties these terms together for the four proteins, and the cluster has no interactions (Edges: 0). This lack of a common theme makes a meaningful, concise label unlikely.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":1},{"id":"GO:0000087","count":1},{"id":"GO:0002143","count":1},{"id":"GO:0018192","count":1},{"id":"GO:0019346","count":1}]},{"hash":"364571089541886822","title":"Developmental Migration and Adhesion Signaling","description":"The top GO terms point to cells moving and sticking in developmental and immune contexts\u2014axonal fasciculation, sprouting angiogenesis, amelogenesis, leukocyte tethering/rolling, T cell activation, endoderm differentiation, plus integrin and Wnt signaling. This suggests a unifying theme of migration coordinated by adhesion and signaling pathways during development and immune processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097186","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0002042","count":2},{"id":"GO:1903238","count":2},{"id":"GO:0016055","count":2}]},{"hash":"1384868485519337965","title":"Neural development and morphogenesis signaling","description":"The top GO terms converge on developmental signaling and neural differentiation, including positive regulation of BMP signaling, axonogenesis, forebrain cell migration, astrocyte differentiation, and collagen fibril organization with cell adhesion. This points to a cohesive theme of neural development and tissue morphogenesis, with heart development appearing as part of broader morphogenic processes. Some terms (e.g., immune signaling, iron homeostasis) may reflect annotation noise rather than core cluster biology, but the predominant pattern supports neural development and morphogenesis. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030513","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0021885","count":3},{"id":"GO:0007156","count":3}]},{"hash":"450493705721331050","title":"Unknown","description":"The top GO terms cover a wide range of developmental and metabolic processes (heart development, luteinization, mammary gland branching, gonad development) with no clear shared function, and there are no edges connecting the proteins, suggesting no cohesive biological theme. Therefore, Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010828","count":1},{"id":"GO:2001250","count":1},{"id":"GO:0045713","count":1},{"id":"GO:0055012","count":1},{"id":"GO:0050680","count":1}]},{"hash":"1573818073350665139","title":"Aminoacyl-tRNA Synthetases and Translation","description":"The cluster is strongly linked to protein synthesis, with GO terms for translation and multiple aminoacyl-tRNA synthetases (Ile, Met, Val, Leu), plus regulation of translational fidelity and antibiotic response, suggesting a function in efficient and accurate translation under stress. A few outliers (intron splicing and androgen metabolism) are present but do not outweigh the translation-centric theme.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006428","count":1},{"id":"GO:0006431","count":1}]},{"hash":"2212097054945522834","title":"Pexophagy and freezing stress response","description":"Top terms indicate a freezing stress response and peroxisome autophagy (pexophagy), pointing to stress-induced organelle turnover as the core function. Other terms (transport, transcription) may reflect broader stress regulation or annotation noise. So the label highlights pexophagy under stress as the cluster theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050826","count":2},{"id":"GO:0030242","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0090180","count":1},{"id":"GO:2001172","count":1}]},{"hash":"197262441082224777","title":"Bone development and calcium signaling regulation","description":"The cluster\u2019s GO terms cluster around bone biology and calcium homeostasis, with ossification and limb development pointing to bone formation, and terms like regulation of calcium ion import and store-operated calcium entry highlighting calcium signaling involvement. Negative regulation of osteoclast differentiation also fits bone remodeling, supporting a cohesive bone-development module.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071248","count":2},{"id":"GO:0045671","count":2},{"id":"GO:0001503","count":2},{"id":"GO:0090281","count":2},{"id":"GO:0002244","count":2}]},{"hash":"1800704901523285335","title":"Unknown","description":"The GO terms among these four proteins are highly diverse, covering transcriptional repression, plasminogen activation, immune defense, development, and enamel formation, with no single dominant function and no observed interactions. There is no clear shared theme to name a cohesive cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0035264","count":2},{"id":"GO:1902947","count":1}]},{"hash":"1240875066522584656","title":"Unknown","description":"The GO terms are highly diverse, including rDNA heterochromatin formation and nucleolar localization, Hsp90 deacetylation, chromatin/nucleosome references, plus stress responses like mitophagy and peroxide-induced cell death, and even plant defense signaling. There is no clear, single biological process that ties these proteins together, so a cohesive functional label cannot be assigned.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045668","count":1},{"id":"GO:0061587","count":1},{"id":"GO:0070846","count":1},{"id":"GO:0000183","count":1},{"id":"GO:0034503","count":1}]},{"hash":"331547635905694164","title":"Unknown","description":"The top GO terms cover a wide range of biological processes (endothelial chemotaxis, phagocytosis, synapse assembly, lipid glycosylation, hormone/secondary metabolite biosynthesis, cell cycle, cell wall organization, genistein response) with little overlap, suggesting no single cohesive function for the cluster. The presence of an obsolete term also indicates limited functional coherence. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001027","count":2},{"id":"GO:0043652","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0030259","count":1},{"id":"GO:0006711","count":1}]},{"hash":"1391972891073498062","title":"Unknown","description":"The top GO terms span several unrelated areas (translation, DNA metabolism, metabolic pathways like PPP and glyceraldehyde-3-phosphate biosynthesis, lipid mobilization) plus immune responses and even a plant-specific root development term, with no consistent functional theme across the proteins. The lack of edges further suggests there isn\u2019t a shared cluster-wide function to name.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0002227","count":1},{"id":"GO:0019731","count":1},{"id":"GO:0006259","count":1},{"id":"GO:0090305","count":1}]},{"hash":"1474366148177527769","title":"Insect cuticle development and molting","description":"The cluster\u2019s strongest signals are about chitin-based cuticle development and remodeling (including chitin catabolic process and ecdysis), which point to insect cuticle formation and molting. Some inflammatory or immune-related terms appear but are likely ancillary annotations, not the main theme. Confidence: High","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0070741","count":1},{"id":"GO:0018990","count":1},{"id":"GO:0040003","count":1}]},{"hash":"37381105600387498","title":"Unknown","description":"The four proteins show GO terms spanning development (larval cuticle, left/right asymmetry), cell division (metaphase/anaphase transition), cilia/centrosome biology (centrosome location, non-motile cilium assembly, photoreceptor outer segments), and immune/stress responses (dsRNA response, interferon-alpha response, LPS metabolism, unfolded protein response). There isn\u2019t a single cohesive function or pathway that ties these terms together, suggesting the cluster does not reflect one clear biological theme. ","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0071360","count":1},{"id":"GO:0051661","count":1},{"id":"GO:0071908","count":1},{"id":"GO:0007091","count":1}]},{"hash":"1322850763285101037","title":"Vesicle trafficking and lipid signaling","description":"Based on the GO terms, the proteins cluster around endosome-to-lysosome transport, plasma membrane tubulation, membrane remodeling, and lipid-mediated signaling (phosphatidic acid and phosphatidylinositol pathways). Dense core granule maturation and polarity regulation reinforce a vesicle/secretory and membrane-dynamics theme, with osteoblast fate commitment appearing as a less central contextual term.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":3},{"id":"GO:2000769","count":2},{"id":"GO:0002051","count":2},{"id":"GO:0097320","count":2},{"id":"GO:0032534","count":2}]},{"hash":"1607763508218698300","title":"Larval chitin-based cuticle development","description":"All four proteins are annotated with the specific GO term for larval chitin-based cuticle development, suggesting a cohesive role in forming or remodeling the chitin-containing larval cuticle. The cluster is tightly tied to this single biological process, supporting a focused structural/developmental function.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4}]},{"hash":"1740641365696061296","title":"Unknown","description":"The GO terms show a broad mix from insect cuticle development to memory, autophagy, hypoxia, and signaling, with no single cohesive function tying the four proteins together. Since there\u2019s no clear common theme and annotations span disparate biology, a confident label isn\u2019t possible.","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0043950","count":1},{"id":"GO:0071313","count":1},{"id":"GO:0060056","count":1},{"id":"GO:0014850","count":1}]},{"hash":"374830215276188214","title":"Actin Cytoskeleton Remodeling and Migration Regulation","description":"The terms point to actin dynamics, notably Arp2/3-mediated actin nucleation, and to regulation (both positive and negative) of cell migration across epithelial and immune cells, plus related processes like axon guidance and membrane/tubulation dynamics\u2014together suggesting a cohesive theme of actin-driven remodeling governing cell movement and signaling in immune and neural contexts.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010633","count":1},{"id":"GO:2000402","count":1},{"id":"GO:0007411","count":1},{"id":"GO:0044397","count":1},{"id":"GO:0010801","count":1}]},{"hash":"487642718882001594","title":"Neural development and signaling","description":"The set of top GO terms centers on neuronal function: transmission of nerve impulse, pyramidal neuron differentiation, neural crest cell migration, and BMP signaling regulation\u2014key components of nervous system development and neuronal signaling. Some terms (immune or morphogenesis-related) are peripheral to this theme, but do not override the dominant neural development signals. Therefore, the label reflects the core function of the cluster.","confidence":"Medium","size":4,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":2},{"id":"GO:0086091","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0030513","count":1},{"id":"GO:0048803","count":1}]},{"hash":"1759373654024082936","title":"Neuronal development and signaling","description":"This cluster is enriched for terms related to nervous system development and neuronal signaling, including nervous system development, hippocampus development, excitatory postsynaptic potential, dopamine response, and ERK/MAPK signaling (ERK1/2 cascade) as well as Wnt signaling, pointing to a cohesive neuronal function group.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":4},{"id":"GO:0000186","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0050852","count":4},{"id":"GO:1903351","count":4}]},{"hash":"1211011879797699399","title":"Transcription Regulation and Neural Development","description":"The top GO terms are dominated by RNA polymerase II\u2013related transcription activities (regulation of transcription by RNA Pol II, DNA-templated transcription, and RNA Pol II preinitiation complex assembly), pointing to transcriptional control as the primary theme. The presence of neural-development terms (neuron migration, negative regulation of neuroblast proliferation) suggests a developmental context for this transcriptional regulation. A few other terms (telomere maintenance, mitochondrial tRNA modification, proteolysis) appear ancillary but do not override the central transcription-focused signal.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007406","count":1},{"id":"GO:0006357","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0000722","count":1}]},{"hash":"805625419193980891","title":"Chromatin Organization and Nucleosome Assembly","description":"The terms cluster around chromatin state and assembly\u2014nucleosome assembly, heterochromatin organization, establishment of localization to chromatin, and histone modification signals\u2014pointing to proteins involved in chromatin structure and epigenetic regulation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":4},{"id":"GO:0098532","count":4},{"id":"GO:0070828","count":4},{"id":"GO:0071169","count":4},{"id":"GO:0080182","count":4}]},{"hash":"2050295309632533720","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031440","count":1},{"id":"GO:0070827","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0006368","count":1},{"id":"GO:0042797","count":1}]},{"hash":"1306481486392892089","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071049","count":1},{"id":"GO:1900050","count":1},{"id":"GO:1902775","count":1},{"id":"GO:1990416","count":1},{"id":"GO:0016457","count":1}]},{"hash":"2033932436357913263","title":"Unknown","description":"Top terms are a mix of nuclear/nucleoplasmic localization, chromatin organization, ribosome biogenesis, apoptosis regulation, UV response, and unrelated plant-specific and signaling terms, with no single cohesive function tying the proteins together. This heterogeneity suggests no clear shared function for the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032066","count":1},{"id":"GO:0002903","count":1},{"id":"GO:2001243","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0010582","count":1}]},{"hash":"51913183302792477","title":"Multisubstrate membrane transporters","description":"The GO terms point to transmembrane transport of diverse substrates\u2014xenobiotics, various sugars (fructose, glucose, xylose, arabinose), nitrite\u2014and even neurotransmitter loading into synaptic vesicles. This pattern suggests a cluster of transporter proteins with broad substrate specificity across membranes rather than a single, narrow function.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:1990539","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0042891","count":3}]},{"hash":"1578974218211489078","title":"Innate immune recognition and phagocytosis signaling","description":"The top GO terms are dominated by innate immune recognition and signaling pathways (C-type lectin receptor signaling, Fc-gamma receptor signaling), phagocytosis and related immune cell activation (phagocytosis, basophil activation, NK cell regulation), and platelet activation, which together point to a cluster centered on innate immune sensing and phagocytic/immune effector functions. Some terms related to development or stress responses appear, but the core theme is innate immune recognition and phagocytic signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":4},{"id":"GO:0090403","count":4},{"id":"GO:0002223","count":4},{"id":"GO:0006910","count":4},{"id":"GO:0038094","count":4}]},{"hash":"1369683730403875145","title":"Mitotic cell cycle and cytokinesis regulation","description":"Top GO terms indicate a clear emphasis on mitosis and cytokinesis (mitotic cell cycle, cell division, regulation of mitotic spindle assembly checkpoint, regulation of cytokinesis). A few other terms (microautophagy, memory, hypoxia) appear sporadically and are likely noise, but do not change the core cell-division theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":1},{"id":"GO:0090266","count":1},{"id":"GO:0043950","count":1},{"id":"GO:0016237","count":1}]},{"hash":"429095261781764704","title":"Immune Activation and Ubiquitin-Mediated Regulation","description":"The most represented GO terms point to adaptive immune responses: T cell proliferation, negative regulation of T-helper cell differentiation, B cell homeostasis, and IL-17 signaling, with activation of NF-kappaB-inducing kinase activity. This indicates a theme of immune cell activation and regulation. The presence of ubiquitin-related processes (protein autoubiquitination, histone H2A K63-linked ubiquitination, ubiquitin-dependent ERAD) suggests regulation of signaling and protein turnover that commonly intersects immune pathways. A few X chromosome inactivation terms appear as noise, but overall the cluster seems to reflect immune signaling modulated by ubiquitin pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042098","count":1},{"id":"GO:1900095","count":1},{"id":"GO:0070535","count":1},{"id":"GO:1903883","count":1},{"id":"GO:0007250","count":1}]},{"hash":"1859368540317792956","title":"Unknown","description":"The top terms reflect a broad, scattered set of processes (caffeine response, sperm motility, jasmonic acid regulation, vasopressin secretion, autophagosome maturation, calcium channel regulation, hormone biosynthesis regulation, pain perception, immune development, sodium transport) with no shared pathway or cellular function. There are no edges, so no network-driven cohesion to tie these proteins to a single function. Therefore no reliable, cohesive label can be assigned beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071313","count":1},{"id":"GO:0030317","count":1},{"id":"GO:0080141","count":1},{"id":"GO:0030103","count":1},{"id":"GO:0097352","count":1}]},{"hash":"2088794612762108356","title":"Immune receptor signaling and protein turnover","description":"The top GO terms point to leukocyte receptor signaling pathways (T cell receptor, C-type lectin receptor, Fc-epsilon receptor signaling) indicating immune receptor activity, while concurrent terms for ubiquitin-proteasome\u2013mediated catabolic processes and apoptosis suggest linkage to protein turnover and cell fate regulation in immune contexts. This combination supports a label focused on immune receptor signaling with associated protein degradation pathways.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0002223","count":2},{"id":"GO:0038095","count":2},{"id":"GO:0031145","count":2}]},{"hash":"2216993052571109860","title":"Mitochondrial protein import and respiration","description":"This cluster centers on mitochondrial biology, with strong signals for protein import into the mitochondrial inner membrane and matrix, involvement in the electron transport chain and aerobic respiration, and proton transmembrane transport, plus respirasome assembly. A chloroplast import term and a couple of unrelated older terms are minor outliers. Overall, the proteins appear connected to mitochondrial targeting and energy metabolism, justifying the label.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0032094","count":1},{"id":"GO:0000002","count":1},{"id":"GO:0045037","count":1}]},{"hash":"1973659300207062766","title":"RNA splicing and translational regulation in stress granules","description":"This cluster centers on positive regulation of mRNA splicing via the spliceosome, localization to cytoplasmic stress granules, and silencing mechanisms via regulatory ncRNA and miRNA pathways, along with regulation of translation initiation. Together, these terms suggest a cohesive role in RNA processing and post-transcriptional control of gene expression, particularly under stress conditions where stress granules form. ","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":2},{"id":"GO:1903608","count":2},{"id":"GO:0031047","count":2},{"id":"GO:1903586","count":1},{"id":"GO:0035278","count":1}]},{"hash":"2102389298639279739","title":"Unknown","description":"There are no GO terms available to define a shared function, and the graph has minimal connectivity (1 edge, max degree 1), offering no clear functional theme. Therefore, Unknown is the appropriate label.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"1020698952697641365","title":"Symbiont-mediated immune suppression","description":"This cluster centers on GO terms about regulating tolerance, antigen processing/presentation via MHC II, and suppression of host adaptive immune responses, including symbiont-driven perturbation of host ubiquitin-like pathways. While there are plant barrier biosynthesis terms (suberin/cutin), the dominant theme is immune modulation by symbionts, making \u201cSymbiont-mediated immune suppression\u201d an apt concise label.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002643","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0002495","count":2},{"id":"GO:0010345","count":2},{"id":"GO:0039648","count":2}]},{"hash":"152176565581470825","title":"Larval chitin-based cuticle development","description":"The only GO signal here is larval chitin-based cuticle development, implying these proteins may be involved in forming or remodeling the larval cuticle. With just a single annotated term and a small cluster, the label is plausible but not strongly supported.","confidence":"Low","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"130677709457489950","title":"Actin Cytoskeleton Dynamics Under Stress","description":"The strongest GO terms are about actin cytoskeleton remodeling (Arp2/3-mediated nucleation, cortical patch assembly, and filament polymerization), suggesting a cluster centered on actin dynamics. Supporting terms point to cellular stress responses (ischemia, hypoxia) and RNA localization/translation control (oskar mRNA localization, miRNA-mediated silencing), which can involve cytoskeletal transport and regulation under stress. Given the mix of direct actin-related processes with stress and RNA localization signals, the cluster likely groups proteins involved in actin-driven remodeling coupled to stress responses and translational control. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034314","count":1},{"id":"GO:0000147","count":1},{"id":"GO:0030041","count":1},{"id":"GO:0002931","count":1},{"id":"GO:1903586","count":1}]},{"hash":"378252630999587532","title":"ER-Golgi and Endosome Vesicle Transport","description":"The top GO terms point to vesicle trafficking events among the ER, Golgi, endosomes, vacuole, and plasma membrane, including ER-to-Golgi transport, intra-Golgi transport, endosome-to-Golgi routing, and Golgi-to-plasma membrane delivery, plus regulation of protein localization to the plasma membrane. This pattern indicates a cluster of proteins involved in intracellular vesicle trafficking across the secretory and endocytic pathways.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0032258","count":2},{"id":"GO:0043001","count":2},{"id":"GO:1903078","count":2}]},{"hash":"1041892235710506431","title":"DNA replication and telomere maintenance","description":"The GO terms cluster around genome stability: DNA replication, DNA repair, and DNA recombination, along with telomere-specific processes (establishment of protein localization to telomere, telomere capping) and a mitotic cell cycle checkpoint signal. While some tRNA-related terms appear, the dominant signal ties to chromosome maintenance and telomere biology, suggesting a cohesive role in genome integrity and replication timing. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007093","count":1},{"id":"GO:0070200","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0070145","count":1},{"id":"GO:0002101","count":1}]},{"hash":"124173011003510279","title":"Mitochondrial metabolism and apoptosis","description":"This cluster is dominated by mitochondrial-related terms: depolarization, outer membrane permeabilization in apoptotic signaling, mitochondrial translation, and heme biosynthesis, with additional hints at ATP regulation. The shared theme centers on mitochondrial energy metabolism and apoptosis-related functions.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001937","count":1},{"id":"GO:0051882","count":1},{"id":"GO:1903214","count":1},{"id":"GO:1903578","count":1},{"id":"GO:1901030","count":1}]},{"hash":"894547556598956424","title":"LPS-driven inflammatory signaling and necroptosis","description":"These proteins cluster around innate immune sensing of lipopolysaccharide and downstream inflammatory responses, including detection of LPS, signaling to promote TNF production, and necroptosis. While a couple of terms (lipid storage, neuromuscular processes, learning) are less connected, the core pattern is LPS-triggered inflammation and necroptotic signaling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032760","count":1},{"id":"GO:0032497","count":1},{"id":"GO:0051345","count":1},{"id":"GO:0031666","count":1},{"id":"GO:0070266","count":1}]},{"hash":"1553122967210113581","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071049","count":2},{"id":"GO:1900050","count":2},{"id":"GO:1902775","count":2},{"id":"GO:1990416","count":2},{"id":"GO:0071042","count":2}]},{"hash":"1020742166685599422","title":"Cellular stress response and protein quality control","description":"Predominant theme is cellular stress response and quality control, including oxidative stress response, autophagosome maturation, aggresome assembly, UV repair, and mitochondrial protein import; these processes together manage damaged proteins and organelle integrity. Some terms like Notch signaling and amino-acid catabolism appear less connected and may represent peripheral associations.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042853","count":2},{"id":"GO:0007219","count":2},{"id":"GO:0097053","count":2},{"id":"GO:0034599","count":1},{"id":"GO:0045041","count":1}]},{"hash":"1183178772438196051","title":"DNA replication and chromatin regulation","description":"The top GO terms are dominated by nuclear DNA replication processes (DNA replication; pre-replicative complex assembly) and chromatin-related activities (histone methylation, heterochromatin formation), with a few development-related or obsolete terms. This suggests the cluster reflects proteins involved in DNA replication and chromatin state regulation, rather than a single signaling pathway. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0007307","count":1},{"id":"GO:0006267","count":1},{"id":"GO:0051568","count":1}]},{"hash":"1932093513245690194","title":"Proviral integration and DNA transposition","description":"The top GO terms cluster around mobility and integration of genetic material: DNA integration, DNA transposition, retrotransposition, and proviral latency, along with related DNA replication/recombination processes. Some terms also touch on viral entry and host interactions, and even RNAi regulation, which can relate to how hosts control or counteract transposable elements and proviruses. Taken together, this set points to a group involved in genome integration and transposable element activity, hence the label.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1201739442035135417","title":"Heat/Light Stress Response and Protein Stabilization","description":"The prominent GO terms point to responses to heat and high light intensity, with additional signals for ROS regulation, growth inhibition, and protein stabilization. These together suggest a stress-response theme focused on protecting cells and maintaining proteins under heat/light stress, with lens-related morphogenesis as a contextual hint. ","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009644","count":2},{"id":"GO:0032387","count":2},{"id":"GO:0007568","count":2},{"id":"GO:1900034","count":2},{"id":"GO:0032463","count":2}]},{"hash":"676809760254129273","title":"Unknown","description":"The listed GO terms span caffeine response, sperm motility, jasmonic acid regulation, vasopressin secretion, pain sensation, development, chemokine production, and multiple signaling processes\u2014across diverse organisms and systems\u2014without a clear shared function. With no edges or interconnected terms, this cluster appears to be a heterogeneous collection rather than a cohesive module, so a reliable functional label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071313","count":1},{"id":"GO:0030317","count":1},{"id":"GO:0080141","count":1},{"id":"GO:0030103","count":1},{"id":"GO:0050968","count":1}]},{"hash":"2165174669915228138","title":"Mitochondrial translation and tRNA charging","description":"The top GO terms point to mitochondrial tRNA aminoacylation for several amino acids (asparaginyl, lysyl, aspartyl) and overall translation, along with tRNA wobble modification. This pattern strongly suggests the cluster comprises proteins involved in mitochondrial protein synthesis and the charging of mt-tRNA, with a few additional terms likely reflecting related processes or context. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070145","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0071915","count":4},{"id":"GO:0070154","count":4},{"id":"GO:0070146","count":4}]},{"hash":"464288484957320581","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009835","count":2},{"id":"GO:2000324","count":2},{"id":"GO:0034354","count":1},{"id":"GO:0006533","count":1},{"id":"GO:0009102","count":1}]},{"hash":"358980487973727759","title":"Multisubstrate membrane transporters","description":"The GO terms point to diverse transmembrane transport activities, including sugar import (fructose, glucose, xylose, arabinose), nitrite and xenobiotic transport, plus neurotransmitter loading into synaptic vesicles. This constellation suggests a small set of membrane transport proteins with broad substrate specificity, potentially including vesicular and solute carrier-type transporters, despite some obsolete terms. Overall, the shared function is clear: membrane transport of multiple substrates.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":4},{"id":"GO:1990539","count":4},{"id":"GO:0015707","count":4},{"id":"GO:0098700","count":4},{"id":"GO:0042891","count":4}]},{"hash":"2192982006143925392","title":"Transmembrane Sugar and Nitrite Transporters","description":"The GO terms cluster around transmembrane transport of various substrates (sugars such as fructose, glucose, xylose, arabinose; nitrite; xenobiotics) and vesicular neurotransmitter loading, which together point to a group of membrane transporter proteins responsible for moving diverse small molecules across membranes.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":4},{"id":"GO:1990539","count":4},{"id":"GO:0015707","count":4},{"id":"GO:0098700","count":4},{"id":"GO:0042891","count":4}]},{"hash":"788694496119910919","title":"Neuronal proteostasis and synaptic regulation","description":"Top GO terms indicate a theme of dampening excitatory synaptic activity (EPSP, glutamatergic transmission) together with neuronal stress and proteostasis processes (unfolded protein response, aggresome assembly, protein ubiquitination, neuron homeostasis). This suggests a cluster focused on coordinating protein quality control with modulation of synaptic function in neurons.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090394","count":3},{"id":"GO:0071287","count":3},{"id":"GO:0051967","count":2},{"id":"GO:0008344","count":2},{"id":"GO:1903378","count":2}]},{"hash":"635069556734196208","title":"Innate Immune Receptor Signaling and Phagocytosis","description":"The top GO terms cluster around innate immune sensing and effector functions, including C-type lectin receptor signaling, Fc-gamma receptor signaling, phagocytosis recognition, basophil activation, and NK cell chemotaxis regulation, pointing to a cohesive theme of innate immune signaling leading to phagocytic responses. Some terms (like development or cartilage) seem supplementary, but the dominant pattern supports an immune-phagocytic function.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":3},{"id":"GO:0090403","count":3},{"id":"GO:0002223","count":3},{"id":"GO:0006910","count":3},{"id":"GO:0038094","count":3}]},{"hash":"2285910708886568244","title":"Unknown","description":"The GO terms span transcription termination, angiogenesis, osteoblast differentiation, mitochondrial ATP synthesis, proteasome storage granule assembly, bacterial flagellum-dependent motility, obsolete protein targeting to mitochondrion, vacuolar acidification, regulation of cell adhesion in migration, and type III secretion. There is no single coherent function or pathway linking these terms, so a unified, specific label isn\u2019t supported.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006353","count":1},{"id":"GO:0001525","count":1},{"id":"GO:0001649","count":1},{"id":"GO:0042776","count":1},{"id":"GO:1902906","count":1}]},{"hash":"1272248274084815678","title":"Ubiquitin-mediated mitotic cycle regulation","description":"Top GO terms emphasize mitotic cell cycle and ubiquitin-proteasome\u2013dependent protein turnover, including SCF-dependent ubiquitin ligase activity. There is also negative regulation of cell population proliferation, pointing to control of cell division. While innate immune response and some development terms appear, they are less represented and likely reflect broader functions or annotation noise, so the central relationship is ubiquitin-mediated regulation of mitosis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0051436","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0071276","count":2}]},{"hash":"1554923815678535967","title":"Embryonic Organogenesis","description":"Top GO terms cluster around development across multiple tissues (neural, heart, cochlea, nephric duct) and differentiation processes, suggesting these proteins participate in broad embryonic organogenesis rather than a single specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0021985","count":3},{"id":"GO:0021846","count":3},{"id":"GO:0010001","count":3},{"id":"GO:0035284","count":3}]},{"hash":"543075081337240518","title":"Embryogenesis and tissue morphogenesis","description":"The GO terms are centered on early development and formation of tissues and organs, including placenta/ trophoblast differentiation, left-right patterning, EMT in heart development, cartilage morphogenesis, and pancreatic cell development, indicating a broad theme of embryonic development and organ morphogenesis rather than a single specific pathway.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0003198","count":3}]},{"hash":"746142760380612894","title":"Unknown","description":"The top GO terms span immune signaling (T cell proliferation), redox response, metabolic and developmental processes, protein maturation, and even obsolete annotations, with no single dominant function linking them. This dispersion, plus annotation noise (obsolete terms), makes it unclear what cohesive biology the cluster represents.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042098","count":1},{"id":"GO:0051775","count":1},{"id":"GO:0061179","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0022417","count":1}]},{"hash":"1712850873223234705","title":"Synaptic vesicle trafficking and exocytosis","description":"The top GO terms cluster around vesicle handling in neurons, including presynaptic dense core vesicle exocytosis, positive regulation of vesicle fusion, and synapse assembly, along with microtubule-associated localization. These points strongly suggest a shared role in vesicle transport and neurotransmitter release at synapses, despite other terms being more peripheral. Thus, labeling this cluster as synaptic vesicle trafficking and exocytosis captures the dominant functional theme.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072699","count":2},{"id":"GO:0001778","count":2},{"id":"GO:0038028","count":2},{"id":"GO:0031384","count":2},{"id":"GO:2000238","count":2}]},{"hash":"689710503677324581","title":"Chromatin organization and histone modification","description":"The dominant terms point to chromatin structure and regulation\u2014nucleosome assembly/heterochromatin organization, histone modifications (H3K27me3, H3K4me3), and transcription control by RNA Pol II\u2014suggesting a cluster of chromatin-associated proteins.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0070828","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0080182","count":2}]},{"hash":"1340422680414186950","title":"Chromatin regulation in development","description":"The cluster\u2019s terms cluster around DNA-templated transcription and chromatin state (histone modification, heterochromatin organization, protein localization to chromatin) alongside diverse developmental differentiation processes (pancreas, skeletal muscle, forebrain glia) and stem cell maintenance, suggesting a shared nuclear regulatory role in developmental gene expression.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0031018","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0035019","count":2},{"id":"GO:0021861","count":2}]},{"hash":"92492856314922016","title":"Chromatin organization and histone modification","description":"The top GO terms cluster around chromatin structure and histone modification\u2014nucleosome assembly, heterochromatin organization, and establishment/localization of proteins to chromatin\u2014point to regulation of chromatin state and nucleosome dynamics. Some historical/obsolete histone marks appear, but the overall theme remains chromatin-based regulation. Minor terms about miRNA silencing and leukocyte migration are less central to this cluster.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":1},{"id":"GO:0098532","count":1},{"id":"GO:0070828","count":1},{"id":"GO:0071169","count":1},{"id":"GO:0080182","count":1}]},{"hash":"1248025479960674055","title":"Unknown","description":"This cluster has no enriched GO terms or connectivity to suggest a common function; with only 3 proteins and zero edges/triangles, there is insufficient evidence to infer a cohesive biological role.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"583182483188265117","title":"Ubiquitination and proteasomal degradation","description":"Top GO terms center on ubiquitination (autoubiquitination, K6-linked, polyubiquitination) and ubiquitin-dependent proteasomal degradation (including SCF-dependent pathways), with a couple RNA-processing terms as minor features. This suggests the proteins form a cluster focused on protein ubiquitination and turnover.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:0085020","count":2},{"id":"GO:0042787","count":2},{"id":"GO:1902916","count":2},{"id":"GO:0031146","count":2}]},{"hash":"1220452676762849544","title":"Unknown","description":"The GO terms are heterogeneous and span unrelated processes (spindle assembly, transcription elongation, heart development, chloroplast import, light response, circulation, centrosome cycle) with no clear shared function linking the proteins. With no edges and only a few terms, there isn\u2019t a cohesive theme to name beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":1},{"id":"GO:0006368","count":1},{"id":"GO:0036302","count":1},{"id":"GO:0045038","count":1},{"id":"GO:0009416","count":1}]},{"hash":"1727155722746841742","title":"Epigenetic and Immune Signaling Regulators","description":"The terms center on epigenetic control (histone H3-K4 demethylation), post-translational modification (protein polyubiquitination), and signaling/immune processes (adaptive immune response, interferon regulation, JUN kinase activity), with additional development-related terms. This suggests a small set of proteins broadly involved in regulating transcription and signaling in immune and developmental contexts rather than a single linear pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034720","count":2},{"id":"GO:0010464","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0021846","count":1},{"id":"GO:0032480","count":1}]},{"hash":"1092914368437856662","title":"Cardiovascular development and remodeling","description":"GO terms show a strong emphasis on cardiovascular-related development: endocardial cushion development, blood circulation, and related mesenchymal and apoptotic processes, all of which are central to heart formation and vascular remodeling. The cell cycle term suggests growth control during tissue morphogenesis, while ectodermal fate commitment and intestinal development appear as broader developmental signals, and inflammatory response hints at niche signaling during tissue remodeling. Overall, the cluster seems to reflect cardiovascular development with remodeling and regulatory processes, with a few terms that seem less directly related.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003197","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0060056","count":1},{"id":"GO:0006954","count":1},{"id":"GO:0033600","count":1}]},{"hash":"2037928422344914273","title":"Protein folding and redox stress response","description":"The top terms point to protein folding/maturation (including prolyl isomerization) and misfolding/amyloid formation, combined with responses to redox state and vitamin E. This suggests a theme around folding-related processes and oxidative stress response, with some unrelated terms (immune activation and heart development) likely representing noise. Overall, the cluster seems best described by folding and redox-related functions, though not perfectly cohesive.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042098","count":1},{"id":"GO:0051775","count":1},{"id":"GO:0061179","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0022417","count":1}]},{"hash":"1508174610523548345","title":"ER Stress and Protein Quality Control","description":"The GO terms cluster around endoplasmic reticulum\u2013related proteostasis: unfolded protein response, ER protein folding, ERAD, and translation changes in response to ER stress, indicating a common theme of maintaining protein quality in the ER. Some peripheral terms (mesoderm formation, axonemal assembly) are likely not central to this cluster. Overall, the dominant function is ER-associated protein folding and stress response.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905259","count":2},{"id":"GO:0006986","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0071374","count":2},{"id":"GO:0036494","count":2}]},{"hash":"169738515753445561","title":"Chitin Metabolism and Inflammatory Signaling","description":"This cluster shows a combination of chitin catabolic process and immune-related terms (production of inflammatory mediators and chemokine production), suggesting a link between carbohydrate metabolism of chitin and inflammatory signaling. The connection is plausible but not strongly cohesive across many terms, given the small cluster size, so confidence is Medium.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0005975","count":2}]},{"hash":"282519168580814291","title":"Ubiquitin-Dependent Transcription Regulation","description":"These terms cluster around transcriptional control by RNA polymerase II (both positive and negative regulation) and DNA-binding modulation, paired with ubiquitin-related processes (autoubiquitination, ERAD) and ER stress\u2013linked apoptotic signaling. This suggests a module where transcription regulation is linked to ubiquitin-mediated protein quality control and stress responses.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043392","count":3},{"id":"GO:0014889","count":3},{"id":"GO:0017085","count":3},{"id":"GO:1902236","count":3},{"id":"GO:0030433","count":3}]},{"hash":"346674860626280989","title":"Nucleolar ribosome biogenesis and rRNA maturation","description":"Based on the top GO terms, the cluster centers on ribosome biogenesis, especially large subunit assembly and maturation of rRNA, with localization to the nucleolus; this indicates a cohesive role in nucleolar RNA processing and ribosome production, despite one outlier term related to cuticle development.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0000055","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0000466","count":1},{"id":"GO:0000463","count":1}]},{"hash":"1920118142105587682","title":"Cytoskeletal Organization and Morphogenesis","description":"The cluster\u2019s GO terms center on cytoskeletal dynamics and cell shape changes, including actin-based structures (filopodium, ruffle assembly) and morphogenetic processes (trabecula morphogenesis, dendritic spine morphogenesis). The presence of mitotic spindle assembly also points to microtubule-driven organization, suggesting a cohesive theme of cytoskeletal remodeling across cellular contexts (neuronal, vascular, and developmental). Confidence: Medium","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0090051","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0061383","count":3}]},{"hash":"2080340921005901270","title":"Larval chitin-based cuticle development","description":"This cluster centers on GO:0008363, indicating larval chitin-based cuticle development; the three proteins share this specific function and the minimal interaction network supports a cohesive role in cuticle formation, justifying the label.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3}]},{"hash":"370959583789035502","title":"Larval chitin-based cuticle development","description":"The single top GO term for this cluster is larval chitin-based cuticle development, indicating the proteins are tied to the formation or modification of the larval insect cuticle composed of chitin. Even though the annotation is sparse (only one hit), the term points to a coherent functional theme around cuticle biosynthesis/structure in larvae.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"1911485428973851633","title":"Unknown","description":"There are no GO terms or functional connections available for this cluster (no edges or terms), making it impossible to infer a coherent shared function. The safest label is Unknown with no confidence.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"278359243719158940","title":"Unknown","description":"The top GO terms are highly diverse, spanning reproductive processes, developmental growth (muscle, skeletal, and facial development), and immune/regulatory activities, with no shared function or molecular mechanism linking them. There are no edges connecting the proteins, and each term appears only once, indicating no cohesive theme for this cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043392","count":1},{"id":"GO:0007620","count":1},{"id":"GO:0048747","count":1},{"id":"GO:2000354","count":1},{"id":"GO:0001501","count":1}]},{"hash":"407458296552463180","title":"H/ACA snoRNP biogenesis and telomerase assembly","description":"The top GO terms center on H/ACA snoRNP assembly and pseudouridylation (snRNA/rRNA), telomerase RNA stabilization/localization to Cajal bodies, and ribosome biogenesis. This converges on RNA-protein complexes that assemble and modify RNAs, especially H/ACA snoRNPs and the telomerase RNP.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905323","count":1},{"id":"GO:0090669","count":1},{"id":"GO:1904874","count":1},{"id":"GO:0000454","count":1},{"id":"GO:0000493","count":1}]},{"hash":"536476415985952064","title":"Larval chitin-based cuticle development","description":"This cluster is driven by GO terms related to larval chitin-based cuticle development and general chitin-based cuticle formation, with body morphogenesis as a broader developmental theme. The two cuticle-related terms suggest a cohesive function in epidermal remodeling or cuticle biosynthesis during larval development, while the other terms (L-arabinose metabolic process and DNA ADP-ribosylation) appear as less connected outliers. Overall, the main signal is developmental cuticle formation, hence the label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0010171","count":1},{"id":"GO:0046373","count":1},{"id":"GO:0030592","count":1}]},{"hash":"1708317898201034168","title":"Sterol and fatty acid biosynthesis","description":"Top GO terms are dominated by lipid metabolism and sterol biosynthesis (cholesterol via lathosterol, ergosterol biosynthesis, ether lipid metabolism, fatty acid biosynthesis), suggesting the proteins are lipid/sterol biosynthesis enzymes. A few unrelated terms likely reflect cross-species annotations.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035754","count":1},{"id":"GO:0032286","count":1},{"id":"GO:0080065","count":1},{"id":"GO:0080064","count":1},{"id":"GO:0033490","count":1}]},{"hash":"480961841248874925","title":"Unknown","description":"This cluster's GO terms span many unrelated processes (Wnt signaling, cuticle development, angiogenesis, cardiac signaling, cell cycle, secretion, neural differentiation, apoptosis, PARylation, nociception), with no single dominant theme. Therefore there isn't a coherent functional signature to name it beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0008363","count":1},{"id":"GO:1903589","count":1},{"id":"GO:0086070","count":1},{"id":"GO:0007049","count":1}]},{"hash":"1079151192516560154","title":"Organ morphogenesis and epithelial polarity","description":"The GO terms cluster around organ development, tissue morphogenesis, junction assembly, and epithelial polarity (e.g., animal organ morphogenesis, maintenance of epithelial cell apical/basal polarity, collagen fibril organization, paranodal junction assembly, branching morphogenesis). This supports labeling the proteins as participants in morphogenesis and tissue architecture. A few terms (positive regulation of synapse maturation, dendritic cell differentiation) are less directly connected, possibly reflecting broader or pleiotropic developmental roles.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090129","count":1},{"id":"GO:0048105","count":1},{"id":"GO:0097028","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0045199","count":1}]},{"hash":"594765974943473747","title":"Ubiquitin-Dependent Protein Regulation","description":"This cluster's top GO terms cluster around ubiquitination and deubiquitination processes (autoubiquitination, ubiquitin-dependent protein catabolic process, free ubiquitin chain polymerization, deubiquitination). These indicate regulation of protein stability and turnover via the ubiquitin system. Other terms like phosphorylation and signaling-related processes are present but represent secondary connections; the strongest signal is ubiquitin cycling, suggesting roles in ubiquitin-mediated regulation of proteostasis and signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:1903071","count":2},{"id":"GO:0010994","count":2},{"id":"GO:0035329","count":2},{"id":"GO:0000413","count":2}]},{"hash":"1381345659002316111","title":"Kinetochore and mitotic chromosome segregation","description":"The GO terms point to centromere/kinetochore assembly (CENP-A), kinetochore localization of the chromosome passenger complex to the spindle midzone, and general mitotic processes like the mitotic cell cycle and chromosome division, with supporting replication/repair-related terms. Together these indicate a cohesive theme of chromosome maintenance during mitosis centered on kinetochores and spindle dynamics.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031297","count":1},{"id":"GO:0034080","count":1},{"id":"GO:0031398","count":1},{"id":"GO:0051382","count":1},{"id":"GO:0000278","count":1}]},{"hash":"450292943904287254","title":"Unknown","description":"Top GO terms across this cluster are highly diverse, spanning cell cycle roles (chromosome passenger complex localization to spindle midzone) to neural development (axon guidance, presynapse assembly), immune differentiation (dendritic and T cell differentiation), and even plant-specific processes (phototropism). With no edges or cohesive functional motif linking the proteins, there isn\u2019t a single interpretable biological theme to name the cluster beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035853","count":1},{"id":"GO:1900477","count":1},{"id":"GO:1905815","count":1},{"id":"GO:2001200","count":1},{"id":"GO:0043380","count":1}]},{"hash":"2302095045290907337","title":"Cell polarity and cytoskeletal remodeling","description":"The top GO terms cluster around regulating cell shape and polarity, along with cytoskeletal dynamics (Rho signaling, actin filament branching) and membrane remodeling (plasma membrane tubulation). Although a few terms seem less related, the dominant themes point to coordinated control of cell polarity, the cytoskeleton, and membrane structure.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000769","count":1},{"id":"GO:1903764","count":1},{"id":"GO:0016560","count":1},{"id":"GO:0002774","count":1},{"id":"GO:0007266","count":1}]},{"hash":"1468045701266747378","title":"Nuclear DNA replication and repair","description":"The GO terms are dominated by nuclear DNA processes: DNA replication, DNA strand displacement, histone exchange, and regulation of double-strand break repair, along with nuclear localization to the nucleoplasm and RNA surveillance, suggesting a nuclear genome maintenance theme. Some terms (mitochondrial ribosomal subunit assembly, BDNF response) are less related and may reflect annotation noise, but the core signal points to nuclear DNA metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0019079","count":3},{"id":"GO:0071049","count":2},{"id":"GO:0032066","count":2},{"id":"GO:0040009","count":2}]},{"hash":"2139840291458066850","title":"ER targeting and translocation via SRP/Sec pathways","description":"The GO terms cluster around targeting of proteins to membranes, especially the endoplasmic reticulum, via SRP-dependent cotranslational translocation and Sec-mediated transport, plus related post-translational membrane targeting. A few terms refer to multicellular development, which may reflect broader annotations or incidental associations; however, the dominant signal is ER-associated protein trafficking machinery.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902416","count":2},{"id":"GO:0039019","count":1},{"id":"GO:0007275","count":1},{"id":"GO:0043952","count":1},{"id":"GO:0006605","count":1}]},{"hash":"468080111709325894","title":"Purine nucleotide biosynthesis and salvage","description":"The top GO terms are dominated by various aspects of purine nucleotide metabolism\u2014ADP/AMP/GTP biosynthesis, ITP metabolism, CDP-related synthesis, nucleoside monophosphate phosphorylation, and purine ribonucleotide interconversion\u2014indicating a cohesive module for purine nucleotide production and salvage. The liver and brain development terms seem incidental to the core metabolic theme rather than defining function. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046041","count":3},{"id":"GO:0046940","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0046939","count":3}]},{"hash":"1190141425883079744","title":"Retroviral DNA integration and proviral latency","description":"The GO terms cluster around retroviral life-cycle steps: viral penetration into the host nucleus, RNA-templated DNA synthesis (reverse transcription), DNA integration into the host genome, and establishment of integrated proviral latency, with supporting hints from DNA replication/recombination and host defense via RNAi regulation. This cohesive theme supports a label focused on retroviral genome integration and latency.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2}]},{"hash":"2217025816776014180","title":"DNA Integration","description":"The top GO term is DNA integration (GO:0015074) with 2 proteins, pointing to a function related to inserting DNA into a genome. The cluster contains 3 proteins and shows no interactions (Edges: 0, Triangles: 0), indicating the grouping is driven by shared annotation rather than network connectivity. A label 'DNA Integration' captures the common theme among these proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2}]},{"hash":"797165217787379141","title":"Notch-regulated development","description":"This cluster centers on terms involving the regulation of Notch signaling (both positive and negative) and various developmental patterning processes across tissues (ovarian follicle development, intestinal epithelial development, somitogenesis, leg segmentation, etc.). The recurring theme is Notch-mediated regulation of development, suggesting these proteins function together in Notch-driven patterning. Confidence: High","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":2},{"id":"GO:0016267","count":2},{"id":"GO:1902367","count":2},{"id":"GO:0007143","count":2},{"id":"GO:0032092","count":2}]},{"hash":"1739598172621149396","title":"Innate immune receptor signaling and phagocytosis","description":"This cluster's GO terms center on immune sensing and effector functions: stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, and phagocytosis recognition, as well as basophil activation and NK cell chemotaxis regulation. Lymph vessel morphogenesis and development-related terms are present but less consistent with the protein set, so the core theme is innate immune receptor signaling and phagocytic activation in myeloid cells.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0036303","count":2},{"id":"GO:0090403","count":2},{"id":"GO:0002223","count":2},{"id":"GO:0006910","count":2},{"id":"GO:0038094","count":2}]},{"hash":"78893890383476134","title":"Unknown","description":"The GO terms are highly diverse (plant cell wall processes, plasmodesma organization, chromatin assembly/remodeling, innate immunity, mRNA decay, etc.) with no single, coherent function spanning all three proteins. The lack of a dominant shared pathway or process makes it not possible to assign a specific, representative label, so Unknown is most appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001009","count":1},{"id":"GO:0009663","count":1},{"id":"GO:0009831","count":1},{"id":"GO:0002227","count":1},{"id":"GO:0006997","count":1}]},{"hash":"2285330243835557974","title":"Retroviral DNA Integration and Latency","description":"The top GO terms cluster around viral genome processing and host interaction, with emphasis on reverse transcription (RNA-templated DNA biosynthetic process), DNA integration, proviral latency, and viral entry into the host nucleus. While a few terms touch broader cellular processes or host apoptosis pathways, the combination strongly points to a retroviral lifecycle involving genome integration and latency rather than ordinary cellular DNA replication. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0006310","count":1}]},{"hash":"436312495753996005","title":"Neural signaling and brain development","description":"The GO terms point to neural development and signaling: serotonergic neuron axon guidance, cerebral cortex regionalization, GPCR-Ca2+/cAMP signaling, and Rho pathways\u2014all indicative of neuronal signaling and brain patterning processes. Some items are broader or more peripheral (stress/behavior, lung morphogenesis), but the core theme centers on neural development and signal transduction.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032792","count":1},{"id":"GO:0036515","count":1},{"id":"GO:0007200","count":1},{"id":"GO:0007266","count":1},{"id":"GO:0060488","count":1}]},{"hash":"1763705365832523821","title":"Neurodevelopmental transcriptional regulation","description":"The top GO terms point strongly to embryonic and neural development (multicellular organism development, neural tube closure, forebrain development, skeletal system development) and transcriptional control (DNA-templated transcription, cellular regulation). While there are also stress/immune-related terms, the dominant signal is developmental gene regulation with a focus on neurodevelopment. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1259067113797576059","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042098","count":1},{"id":"GO:0070535","count":1},{"id":"GO:1903883","count":1},{"id":"GO:0007250","count":1},{"id":"GO:0030433","count":1}]},{"hash":"249546684142294877","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0007200","count":2},{"id":"GO:2000011","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0007584","count":2}]},{"hash":"908272275401024925","title":"Oxidative stress response and redox regulation","description":"The top GO terms cluster around redox biology: cellular response to oxidative stress, cell redox homeostasis, oxidant detoxification, and protein deglutathionylation, which together point to redox signaling and oxidative stress responses. A few outlier terms (methylamine metabolism and neural crest cell migration in heart formation) are unlikely to reflect a single cohesive function for this small set, likely representing annotation noise. Overall, the dominant redox-related terms support a redox/oxidative stress function for this cluster.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034599","count":1},{"id":"GO:0030416","count":1},{"id":"GO:0071473","count":1},{"id":"GO:0003147","count":1},{"id":"GO:1903026","count":1}]},{"hash":"1582512518670552087","title":"Embryonic organ morphogenesis","description":"The top GO terms show morphogenesis and development across multiple organs (inner ear, forebrain, optic cup, cardiac muscle), indicating a developmental, multi-tissue morphogenesis theme. Some metabolic terms (GABA and ethanol-related processes) appear but do not override the central developmental signal, suggesting these proteins are involved in organ formation more than a single metabolic pathway.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006069","count":2},{"id":"GO:0042472","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0006068","count":2},{"id":"GO:0006540","count":2}]},{"hash":"400197360690321251","title":"Chromatin organization and nucleosome assembly","description":"These terms cluster around chromatin architecture and chromatin-associated processes: nucleosome assembly, heterochromatin organization, protein localization to chromatin, and regulation of nucleus size, with historical references to histone modifications. The combined hints point to proteins involved in organizing chromatin structure and nucleosome dynamics.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":3},{"id":"GO:0098532","count":3},{"id":"GO:0070828","count":3},{"id":"GO:0071169","count":3},{"id":"GO:0080182","count":3}]},{"hash":"1234002206206603498","title":"Neural and Sensory Development with Metabolic Pathways","description":"Most terms point to development and morphogenesis of neural and sensory tissues (forebrain, optic cup, inner ear) with supporting metabolic pathways (ethanol/GABA metabolism). This makes the label a concise reflection of the cluster\u2019s central theme, though some terms reference other organs, indicating a broader developmental context.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006069","count":3},{"id":"GO:0042472","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0006068","count":3},{"id":"GO:0006540","count":3}]},{"hash":"1345411669596831272","title":"Unknown","description":"The GO terms span immune adhesion, vascular signaling, neural development, extracellular matrix organization, and synaptic processes, with no single dominant function tying the cluster together; as a result, there is no confident, cohesive label that accurately represents the set.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050901","count":2},{"id":"GO:0030949","count":1},{"id":"GO:0035024","count":1},{"id":"GO:0021943","count":1},{"id":"GO:0035001","count":1}]},{"hash":"1873009874110466401","title":"Ubiquitin-Dependent Proteolysis and Endosomal Sorting","description":"Primarily indicates ubiquitin-dependent proteolysis and endosomal sorting (MVB pathway), with K29-linked ubiquitination; ancillary terms on cell cycle and signaling regulation suggest a cluster around ubiquitin-mediated turnover influencing signaling and division.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030512","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0043524","count":1},{"id":"GO:0097676","count":1},{"id":"GO:0019089","count":1}]},{"hash":"191006909077941962","title":"GPCR-cAMP Signaling","description":"This cluster is dominated by GO terms tied to G protein-coupled receptor signaling and cAMP production (adenylate cyclase-activating GPCR signaling, cAMP biosynthetic process, PLC-activating GPCR signaling), which points to a shared function of GPCR-mediated signal transduction that regulates cAMP levels. Some neural and vascular terms (serotonergic neuron guidance, positive regulation of blood pressure) fit within GPCR roles in neural signaling and blood pressure control; a peripheral term 'electron transport chain' may reflect metabolic or housekeeping associations but does not override the main theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":2},{"id":"GO:0010579","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0032792","count":1},{"id":"GO:0036515","count":1}]}]