{"hash":"812277152329680400","title":"Epithelial differentiation and systemic signaling","description":"This cluster centers on keratinization and hair cycle (epidermal/follicle differentiation) and includes epithelial-associated immune differentiation (intraepithelial T cells), plus a set of broader neuroendocrine/visceral processes (gastric secretion, peristalsis, circadian rhythm, urine volume, dopamine/octopamine signaling). The shared theme appears to be regulation of epithelial tissue development/remodeling together with systemic signaling across organ systems, rather than a single, narrow function. ","confidence":"Medium","size":17,"edges":119,"triangles":465,"max_degree":16,"top_function":"inflammatory response","members":[{"accession":"XP_070083417.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_005606272.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_005606273.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_014595946.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_023503009.1","go_terms":[]},{"accession":"XP_014591873.3","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_014591917.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_005606274.3","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_014591874.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_014591914.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_001497377.1","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_014595892.2","go_terms":["GO:0042633","GO:0031424"]},{"accession":"XP_066910009.2","go_terms":["GO:0030321","GO:2000522","GO:0045907","GO:2000526","GO:0046887","GO:0035106","GO:0051281","GO:0060658","GO:0045986","GO:0060158","GO:0001985","GO:0007218","GO:0072224","GO:0007211","GO:0051209","GO:0046879","GO:0002300","GO:0002305","GO:0048290","GO:2000420","GO:0007596","GO:0060259","GO:2000724","GO:0032651","GO:2000484","GO:0014827","GO:0043950","GO:0042752","GO:0034776","GO:0046960","GO:0001992","GO:0001991","GO:0015872","GO:0001997","GO:0055117","GO:0030168","GO:0001994","GO:0022900","GO:1900168","GO:0016056","GO:0007202","GO:0090075","GO:0001698","GO:0046849","GO:1903141","GO:0001697","GO:0045494","GO:0035926","GO:1902239","GO:1900453","GO:0042742","GO:0051586","GO:0048245","GO:0032496","GO:0032228","GO:0019835","GO:0021853","GO:0043547","GO:0035645","GO:0019233","GO:0016998","GO:0071799","GO:0046541","GO:0007626","GO:0007625","GO:0090198","GO:0035625","GO:1900134","GO:0050796","GO:0060160","GO:0019076","GO:0006954","GO:0006955","GO:0002882","GO:0070963","GO:0042755","GO:0071502","GO:0033861","GO:0043311","GO:0007199","GO:0007198","GO:0051967","GO:0001973","GO:0007191","GO:0007190","GO:0007195","GO:0007194","GO:0007197","GO:0003093","GO:0032100","GO:0042391","GO:2000479","GO:0099553","GO:0007603","GO:0002407","GO:0007208","GO:0032962","GO:0009253","GO:0042053","GO:0008542","GO:0001662","GO:0001545","GO:0035025","GO:0002024","GO:0045745","GO:1904156","GO:0043006","GO:1904155","GO:0070474","GO:0071883","GO:0071880","GO:0071881","GO:0097029","GO:0008284","GO:0060427","GO:0007507","GO:0072610","GO:0071882","GO:0039553","GO:1900135","GO:0043278","GO:0014063","GO:0031649","GO:0007497","GO:0010579","GO:0071407","GO:0042493","GO:0048484","GO:0032675","GO:0002035","GO:0001963","GO:0002031","GO:0032720","GO:0002033","GO:0002032","GO:0070374","GO:0014829","GO:0070098","GO:0072608","GO:0071380","GO:0060134","GO:0022400","GO:0002879","GO:0014059","GO:0001996","GO:0048609","GO:0001975","GO:0036145","GO:0060041","GO:0090023","GO:0051930","GO:0071417","GO:0008283","GO:0003245","GO:0002025","GO:0035810","GO:1901386","GO:0035815","GO:0061358","GO:0010818","GO:0031635","GO:0006468","GO:0050728","GO:0007601","GO:0060408","GO:0018298","GO:0090026","GO:0022410","GO:0030432","GO:0010759","GO:0048148","GO:0040015","GO:0045777","GO:0051482","GO:2000458","GO:1901652","GO:0010513","GO:0016038","GO:0043114","GO:0070257"]},{"accession":"NP_001377869.1","go_terms":["GO:0030321","GO:2000522","GO:0045907","GO:2000526","GO:0046887","GO:0035106","GO:0051281","GO:0060658","GO:0045986","GO:0060158","GO:0001985","GO:0007218","GO:0072224","GO:0007211","GO:0051209","GO:0046879","GO:0002300","GO:0002305","GO:0048290","GO:2000420","GO:0007596","GO:0060259","GO:2000724","GO:0032651","GO:2000484","GO:0014827","GO:0043950","GO:0042752","GO:0034776","GO:0046960","GO:0001992","GO:0001991","GO:0015872","GO:0001997","GO:0055117","GO:0030168","GO:0001994","GO:0022900","GO:1900168","GO:0016056","GO:0007202","GO:0090075","GO:0001698","GO:0046849","GO:1903141","GO:0001697","GO:0045494","GO:0035926","GO:1902239","GO:1900453","GO:0042742","GO:0051586","GO:0048245","GO:0032496","GO:0032228","GO:0019835","GO:0021853","GO:0043547","GO:0035645","GO:0019233","GO:0016998","GO:0071799","GO:0046541","GO:0007626","GO:0007625","GO:0090198","GO:0035625","GO:1900134","GO:0050796","GO:0060160","GO:0019076","GO:0006954","GO:0006955","GO:0002882","GO:0070963","GO:0042755","GO:0071502","GO:0033861","GO:0043311","GO:0007199","GO:0007198","GO:0051967","GO:0001973","GO:0007191","GO:0007190","GO:0007195","GO:0007194","GO:0007197","GO:0003093","GO:0032100","GO:0042391","GO:2000479","GO:0099553","GO:0007603","GO:0002407","GO:0007208","GO:0032962","GO:0009253","GO:0042053","GO:0008542","GO:0001662","GO:0001545","GO:0035025","GO:0002024","GO:0045745","GO:1904156","GO:0043006","GO:1904155","GO:0070474","GO:0071883","GO:0071880","GO:0071881","GO:0097029","GO:0008284","GO:0060427","GO:0007507","GO:0072610","GO:0071882","GO:0039553","GO:1900135","GO:0043278","GO:0014063","GO:0031649","GO:0007497","GO:0010579","GO:0071407","GO:0042493","GO:0048484","GO:0032675","GO:0002035","GO:0001963","GO:0002031","GO:0032720","GO:0002033","GO:0002032","GO:0070374","GO:0014829","GO:0070098","GO:0072608","GO:0071380","GO:0060134","GO:0022400","GO:0002879","GO:0014059","GO:0001996","GO:0048609","GO:0001975","GO:0036145","GO:0060041","GO:0090023","GO:0051930","GO:0071417","GO:0008283","GO:0003245","GO:0002025","GO:0035810","GO:1901386","GO:0035815","GO:0061358","GO:0010818","GO:0031635","GO:0006468","GO:0050728","GO:0007601","GO:0060408","GO:0018298","GO:0090026","GO:0022410","GO:0030432","GO:0010759","GO:0048148","GO:0040015","GO:0045777","GO:0051482","GO:2000458","GO:1901652","GO:0010513","GO:0016038","GO:0043114","GO:0070257"]},{"accession":"NP_001378040.1","go_terms":["GO:0030321","GO:2000522","GO:0045907","GO:2000526","GO:0046887","GO:0035106","GO:0051281","GO:0060658","GO:0045986","GO:0060158","GO:0001985","GO:0007218","GO:0072224","GO:0007211","GO:0051209","GO:0046879","GO:0002300","GO:0002305","GO:0048290","GO:2000420","GO:0007596","GO:0060259","GO:2000724","GO:0032651","GO:2000484","GO:0014827","GO:0043950","GO:0042752","GO:0034776","GO:0046960","GO:0001992","GO:0001991","GO:0015872","GO:0001997","GO:0055117","GO:0030168","GO:0001994","GO:0022900","GO:1900168","GO:0016056","GO:0007202","GO:0090075","GO:0001698","GO:0046849","GO:1903141","GO:0001697","GO:0045494","GO:0035926","GO:1902239","GO:1900453","GO:0042742","GO:0051586","GO:0048245","GO:0032496","GO:0032228","GO:0019835","GO:0021853","GO:0043547","GO:0035645","GO:0019233","GO:0016998","GO:0071799","GO:0046541","GO:0007626","GO:0007625","GO:0090198","GO:0035625","GO:1900134","GO:0050796","GO:0060160","GO:0019076","GO:0006954","GO:0006955","GO:0002882","GO:0070963","GO:0042755","GO:0071502","GO:0033861","GO:0043311","GO:0007199","GO:0007198","GO:0051967","GO:0001973","GO:0007191","GO:0007190","GO:0007195","GO:0007194","GO:0007197","GO:0003093","GO:0032100","GO:0042391","GO:2000479","GO:0099553","GO:0007603","GO:0002407","GO:0007208","GO:0032962","GO:0009253","GO:0042053","GO:0008542","GO:0001662","GO:0001545","GO:0035025","GO:0002024","GO:0045745","GO:1904156","GO:0043006","GO:1904155","GO:0070474","GO:0071883","GO:0071880","GO:0071881","GO:0097029","GO:0008284","GO:0060427","GO:0007507","GO:0072610","GO:0071882","GO:0039553","GO:1900135","GO:0043278","GO:0014063","GO:0031649","GO:0007497","GO:0010579","GO:0071407","GO:0042493","GO:0048484","GO:0032675","GO:0002035","GO:0001963","GO:0002031","GO:0032720","GO:0002033","GO:0002032","GO:0070374","GO:0014829","GO:0070098","GO:0072608","GO:0071380","GO:0060134","GO:0022400","GO:0002879","GO:0014059","GO:0001996","GO:0048609","GO:0001975","GO:0036145","GO:0060041","GO:0090023","GO:0051930","GO:0071417","GO:0008283","GO:0003245","GO:0002025","GO:0035810","GO:1901386","GO:0035815","GO:0061358","GO:0010818","GO:0031635","GO:0006468","GO:0050728","GO:0007601","GO:0060408","GO:0018298","GO:0090026","GO:0022410","GO:0030432","GO:0010759","GO:0048148","GO:0040015","GO:0045777","GO:0051482","GO:2000458","GO:1901652","GO:0010513","GO:0016038","GO:0043114","GO:0070257"]},{"accession":"XP_001492953.2","go_terms":["GO:0010226","GO:0000388"]},{"accession":"XP_023486057.1","go_terms":["GO:0042633","GO:0031424"]}],"graph":[["XP_070083417.1","XP_005606272.1",0.952],["XP_070083417.1","XP_005606273.1",0.981],["XP_070083417.1","XP_005606274.3",0.975],["XP_070083417.1","XP_014591873.3",0.975],["XP_070083417.1","XP_014591874.1",0.942],["XP_070083417.1","XP_014591914.1",0.943],["XP_070083417.1","XP_014591917.1",0.962],["XP_070083417.1","XP_014595892.2",0.938],["XP_070083417.1","XP_066910009.2",0.766],["XP_070083417.1","NP_001377869.1",0.783],["XP_070083417.1","NP_001378040.1",0.841],["XP_070083417.1","XP_001497377.1",0.974],["XP_014591917.1","XP_023503009.1",0.988],["XP_014591917.1","XP_023486057.1",0.985],["XP_014591917.1","XP_066910009.2",0.988],["XP_014591917.1","NP_001377869.1",0.988],["XP_014591917.1","NP_001378040.1",0.972],["XP_014591917.1","XP_001492953.2",0.983],["XP_014591917.1","XP_001497377.1",0.969],["XP_014591917.1","XP_005606272.1",0.979],["XP_014591917.1","XP_005606273.1",0.972],["XP_014591917.1","XP_005606274.3",0.969],["XP_014591917.1","XP_014591873.3",0.979],["XP_014591917.1","XP_014591874.1",0.93],["XP_014591917.1","XP_014591914.1",0.98],["XP_014591917.1","XP_014595892.2",0.98],["XP_014591917.1","XP_014595946.1",0.969],["NP_001377869.1","XP_001497377.1",0.978],["NP_001377869.1","XP_014595892.2",0.506],["NP_001377869.1","XP_014595946.1",0.855],["NP_001377869.1","XP_014591873.3",0.872],["NP_001377869.1","XP_014591874.1",0.977],["NP_001377869.1","XP_014591914.1",0.98],["NP_001377869.1","XP_005606272.1",0.765],["NP_001377869.1","XP_005606273.1",0.962],["NP_001377869.1","XP_005606274.3",0.976],["NP_001377869.1","XP_023486057.1",0.901],["XP_023503009.1","XP_014591873.3",0.991],["XP_023503009.1","XP_014591874.1",0.988],["XP_023503009.1","XP_014591914.1",0.987],["XP_023503009.1","XP_014595892.2",0.982],["XP_023503009.1","XP_014595946.1",0.748],["XP_023503009.1","XP_023486057.1",0.984],["XP_023503009.1","XP_001492953.2",0.763],["XP_023503009.1","XP_001497377.1",0.982],["XP_023503009.1","XP_005606272.1",0.972],["XP_023503009.1","XP_005606273.1",0.976],["XP_023503009.1","XP_005606274.3",0.979],["XP_005606273.1","XP_066910009.2",0.962],["XP_005606273.1","NP_001378040.1",0.962],["XP_005606273.1","XP_001492953.2",0.98],["XP_005606273.1","XP_001497377.1",0.984],["XP_005606273.1","XP_014595892.2",0.974],["XP_005606273.1","XP_014595946.1",0.984],["XP_005606273.1","XP_014591873.3",0.984],["XP_005606273.1","XP_014591874.1",0.979],["XP_005606273.1","XP_014591914.1",0.941],["XP_005606273.1","XP_005606272.1",0.969],["XP_005606273.1","XP_005606274.3",0.984],["XP_005606273.1","XP_023486057.1",0.965],["XP_014591914.1","XP_066910009.2",0.874],["XP_014591914.1","NP_001378040.1",0.959],["XP_014591914.1","XP_001492953.2",0.976],["XP_014591914.1","XP_001497377.1",0.98],["XP_014591914.1","XP_005606272.1",0.665],["XP_014591914.1","XP_005606274.3",0.97],["XP_014591914.1","XP_014591873.3",0.979],["XP_014591914.1","XP_014591874.1",0.98],["XP_014591914.1","XP_014595892.2",0.974],["XP_014591914.1","XP_014595946.1",0.986],["NP_001378040.1","XP_001497377.1",0.978],["NP_001378040.1","XP_014595946.1",0.748],["NP_001378040.1","XP_014591873.3",0.975],["NP_001378040.1","XP_014591874.1",0.971],["NP_001378040.1","XP_005606272.1",0.942],["NP_001378040.1","XP_005606274.3",0.972],["NP_001378040.1","XP_023486057.1",0.803],["XP_014595946.1","XP_023486057.1",0.99],["XP_014595946.1","XP_066910009.2",0.876],["XP_014595946.1","XP_001492953.2",0.75],["XP_014595946.1","XP_001497377.1",0.984],["XP_014595946.1","XP_005606272.1",0.975],["XP_014595946.1","XP_005606274.3",0.984],["XP_014595946.1","XP_014591873.3",0.977],["XP_014595946.1","XP_014591874.1",0.975],["XP_014595946.1","XP_014595892.2",0.989],["XP_005606274.3","XP_066910009.2",0.874],["XP_005606274.3","XP_001492953.2",0.989],["XP_005606274.3","XP_001497377.1",0.983],["XP_005606274.3","XP_014595892.2",0.963],["XP_005606274.3","XP_014591873.3",0.962],["XP_005606274.3","XP_014591874.1",0.98],["XP_005606274.3","XP_005606272.1",0.97],["XP_005606274.3","XP_023486057.1",0.984],["XP_014591874.1","XP_023486057.1",0.912],["XP_014591874.1","XP_066910009.2",0.98],["XP_014591874.1","XP_001492953.2",0.984],["XP_014591874.1","XP_001497377.1",0.977],["XP_014591874.1","XP_005606272.1",0.953],["XP_014591874.1","XP_014591873.3",0.979],["XP_014591874.1","XP_014595892.2",0.958],["XP_066910009.2","XP_005606272.1",0.937],["XP_066910009.2","XP_014591873.3",0.934],["XP_066910009.2","XP_023486057.1",0.938],["XP_066910009.2","XP_001497377.1",0.978],["XP_001492953.2","XP_001497377.1",0.978],["XP_001492953.2","XP_005606272.1",0.991],["XP_001492953.2","XP_014591873.3",0.985],["XP_001492953.2","XP_014595892.2",0.964],["XP_001492953.2","XP_023486057.1",0.935],["XP_001497377.1","XP_014595892.2",0.986],["XP_001497377.1","XP_014591873.3",0.839],["XP_001497377.1","XP_005606272.1",0.953],["XP_001497377.1","XP_023486057.1",0.99],["XP_023486057.1","XP_014591873.3",0.927],["XP_023486057.1","XP_014595892.2",0.98],["XP_014591873.3","XP_005606272.1",0.959],["XP_014591873.3","XP_014595892.2",0.938],["XP_005606272.1","XP_014595892.2",0.963]],"all_go_terms":{"GO:0031424":12,"GO:0042633":12,"GO:0035810":3,"GO:0022410":3,"GO:0001697":3,"GO:0030432":3,"GO:0007211":3,"GO:0060158":3,"GO:0002305":3,"GO:0046849":3,"GO:0048609":3,"GO:0002025":3,"GO:0046960":3,"GO:0097029":3,"GO:0060134":3,"GO:1900453":3,"GO:0001545":3,"GO:0002300":3,"GO:0001698":3,"GO:0008542":3,"GO:0015872":3,"GO:0071881":3,"GO:0035625":3,"GO:0071883":3,"GO:0071882":3,"GO:0039553":3,"GO:0060041":3,"GO:0051967":3,"GO:0035106":3,"GO:0048148":3,"GO:0030321":3,"GO:0001992":3,"GO:2000526":3,"GO:1902239":3,"GO:0071407":3,"GO:0002882":3,"GO:0071880":3,"GO:0035815":3,"GO:2000458":3,"GO:2000484":3,"GO:0046541":3,"GO:1900168":3,"GO:0060408":3,"GO:0043278":3,"GO:0007195":3,"GO:0070474":3,"GO:0071799":3,"GO:0007190":3,"GO:0003093":3,"GO:0001975":3,"GO:0060427":3,"GO:0070257":3,"GO:0043006":3,"GO:0060160":3,"GO:0001662":3,"GO:0002024":3,"GO:0018298":3,"GO:0046879":3,"GO:0007497":3,"GO:1904156":3,"GO:0035926":3,"GO:0042053":3,"GO:0036145":3,"GO:0032651":3,"GO:2000724":3,"GO:0001973":3,"GO:0022400":3,"GO:0072224":3,"GO:0032228":3,"GO:0046887":3,"GO:2000420":3,"GO:0032720":3,"GO:0045494":3,"GO:0043311":3,"GO:0002879":3,"GO:0007507":3,"GO:0007603":3,"GO:0055117":3,"GO:0001963":3,"GO:0001985":3,"GO:0042493":3,"GO:0001996":3,"GO:0001994":3,"GO:1900134":3,"GO:0060259":3,"GO:0002407":3,"GO:0051209":3,"GO:0045745":3,"GO:0008284":3,"GO:0045986":3,"GO:0042755":3,"GO:0045777":3,"GO:0002032":3,"GO:0002033":3,"GO:0035025":3,"GO:0071380":3,"GO:0014059":3,"GO:0043114":3,"GO:0007596":3,"GO:0016038":3,"GO:0010759":3,"GO:0010513":3,"GO:0051586":3,"GO:0043547":3,"GO:0016056":3,"GO:0019076":3,"GO:0019233":3,"GO:0007198":3,"GO:0035645":3,"GO:1900135":3,"GO:0042752":3,"GO:0010579":3,"GO:0070963":3,"GO:1901652":3,"GO:0010818":3,"GO:0001997":3,"GO:0040015":3,"GO:0043950":3,"GO:0016998":3,"GO:0032962":3,"GO:0031649":3,"GO:1904155":3,"GO:0007202":3,"GO:0014829":3,"GO:0071502":3,"GO:0048290":3,"GO:0014827":3,"GO:2000522":3,"GO:0045907":3,"GO:0007191":3,"GO:0002031":3,"GO:0051482":3,"GO:0048484":3,"GO:0007626":3,"GO:0090198":3,"GO:0072608":3,"GO:0022900":3,"GO:0061358":3,"GO:0072610":3,"GO:0050728":3,"GO:0006468":3,"GO:0006955":3,"GO:0048245":3,"GO:0033861":3,"GO:0007601":3,"GO:0034776":3,"GO:0007218":3,"GO:0042742":3,"GO:0007625":3,"GO:0002035":3,"GO:0019835":3,"GO:0032675":3,"GO:0051930":3,"GO:0008283":3,"GO:0006954":3,"GO:0070374":3,"GO:1901386":3,"GO:0090023":3,"GO:0060658":3,"GO:0007199":3,"GO:0031635":3,"GO:0007194":3,"GO:0030168":3,"GO:0014063":3,"GO:0021853":3,"GO:0051281":3,"GO:0099553":3,"GO:0050796":3,"GO:0032100":3,"GO:0070098":3,"GO:2000479":3,"GO:0003245":3,"GO:0032496":3,"GO:0042391":3,"GO:1903141":3,"GO:0007197":3,"GO:0007208":3,"GO:0071417":3,"GO:0090075":3,"GO:0090026":3,"GO:0001991":3,"GO:0009253":3,"GO:0000388":1,"GO:0010226":1},"recipe_readded":[]}