{"hash":"733447883149252650","title":"Amino acid metabolism and vitamin biosynthesis","description":"The cluster shows strong representation of amino acid\u2013related processes (L-alanine and L-kynurenine catabolism, glycine and tryptophan biosynthesis/catabolism, pyruvate biosynthesis) and vitamin B6 (pyridoxine) biosynthesis, suggesting a core theme around amino acid metabolism and cofactor biosynthesis. A mitochondrial tRNA thio-modification and cAMP response terms add some signaling and RNA-modification context, but the dominant pattern appears metabolic rather than a single signaling pathway. The Notch signaling term seems to be an outlier relative to the main metabolic themes, so the label captures the majority function of the cluster.","confidence":"Medium","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"members":[{"accession":"NP_001157295.1","go_terms":["GO:0006099","GO:0009060","GO:0022904","GO:0044780","GO:0019516","GO:0006113","GO:0015948","GO:0071973","GO:0019684","GO:0055114"]},{"accession":"NP_001296201.1","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109"]},{"accession":"XP_001488609.1","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109"]},{"accession":"XP_023500514.1","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109","GO:0019367","GO:0051790","GO:0017000","GO:0051792"]},{"accession":"XP_014595895.2","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_023471886.1","go_terms":["GO:0006633","GO:0017000","GO:0009245","GO:1902987","GO:0009258","GO:0019878","GO:0043041","GO:0071555","GO:0070395","GO:0070400"]},{"accession":"XP_023471887.1","go_terms":["GO:0006633","GO:0017000","GO:0009245","GO:1902987","GO:0009258","GO:0019878","GO:0043041","GO:0071555","GO:0070395","GO:0070400"]},{"accession":"XP_023488714.1","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109","GO:0019367","GO:0051790","GO:0017000","GO:0051792"]},{"accession":"XP_023500336.1","go_terms":["GO:0006515"]},{"accession":"XP_001918227.2","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109","GO:0019367","GO:0051790","GO:0017000","GO:0051792"]},{"accession":"XP_023475873.1","go_terms":["GO:0006085","GO:0006099","GO:0006104"]},{"accession":"XP_001488662.2","go_terms":["GO:0043617","GO:0006086","GO:0033512","GO:0006213","GO:0006099","GO:0006096","GO:0000002","GO:0006103","GO:0006814","GO:2001295","GO:0042759","GO:0006552","GO:0006094"]},{"accession":"XP_001490027.4","go_terms":["GO:0006085","GO:0006099","GO:0006104"]},{"accession":"XP_001503364.2","go_terms":["GO:0043617","GO:0006086","GO:0033512","GO:0006213","GO:0006099","GO:0006096","GO:0000002","GO:0006103","GO:0006814","GO:2001295","GO:0042759","GO:0006552","GO:0006094"]},{"accession":"XP_070103699.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103"]},{"accession":"XP_001499873.3","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103"]},{"accession":"XP_070081978.1","go_terms":["GO:0006545","GO:0006567","GO:0006570","GO:0006569"]},{"accession":"NP_001421622.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"access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