{"hash":"1096793560142271596","title":"Ubiquitin-dependent ERAD and ER stress regulators","description":"This cluster\u2019s top GO terms cluster around ubiquitin-related processes\u2014ubiquitin-dependent ERAD, deubiquitination, and autoubiquitination\u2014plus regulation of ER stress-induced apoptotic signaling, pointing to proteins involved in ubiquitin-mediated protein quality control and ER-associated degradation. Additional terms hint at connections to mitochondrial dynamics and transcription regulation, suggesting broader roles in protein homeostasis and stress response. Overall, the common theme is maintenance of protein quality and stress response via ubiquitin signaling, justifying a label centered on ERAD/ubiquitination with stress regulatory functions.","confidence":"Medium","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"members":[{"accession":"XP_014595654.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_001501835.2","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907","GO:0030307","GO:0002088","GO:0001666","GO:0007021","GO:0051260","GO:0045766","GO:0060561","GO:0006937","GO:0048596","GO:0007525","GO:0010667","GO:0043154"]},{"accession":"XP_070096236.1","go_terms":["GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_070116108.1","go_terms":[]},{"accession":"XP_070120548.1","go_terms":["GO:0048565","GO:1900006","GO:1900029","GO:0033504","GO:0048669","GO:0051639","GO:0001889","GO:0000578","GO:0030903","GO:0030041","GO:0001757","GO:0001843"]},{"accession":"XP_070128647.1","go_terms":[]},{"accession":"XP_001488427.3","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412","GO:0051607","GO:0018377","GO:0045071","GO:0060700","GO:0045087"]},{"accession":"XP_001490739.1","go_terms":["GO:0048575","GO:0030154","GO:0060409","GO:0042755","GO:0010229","GO:0010951","GO:0048240","GO:0007275","GO:0009911","GO:0009910","GO:0048510","GO:0009908"]},{"accession":"XP_001493237.1","go_terms":["GO:0045600","GO:0032981"]},{"accession":"XP_001493670.1","go_terms":["GO:0000266","GO:0048140","GO:1990182","GO:0001731","GO:0075522","GO:0016559","GO:0043161","GO:0035871","GO:0070452","GO:0070537","GO:0006281","GO:0000338","GO:0006446","GO:0045471","GO:0010387","GO:0035522","GO:0010950","GO:0014067","GO:0000393","GO:0034286","GO:0051726","GO:1902906","GO:0000398","GO:1903894"]},{"accession":"XP_001501591.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"XP_005601177.1","go_terms":[]},{"accession":"XP_005607123.1","go_terms":["GO:0034389","GO:0007253","GO:0031134","GO:1904293","GO:0031468","GO:0002814","GO:2000157","GO:0030433","GO:0061060","GO:0008219","GO:1903094"]},{"accession":"XP_023499044.1","go_terms":["GO:0038168","GO:2000182","GO:1990126","GO:0030033","GO:0043950","GO:0010801","GO:0034334","GO:0010667","GO:1901223","GO:0035021","GO:0019933","GO:0090557","GO:0070493","GO:0048022","GO:0000161","GO:0071880","GO:2000481","GO:0032835","GO:0060019","GO:1902634","GO:0051591","GO:0032486","GO:0032485","GO:0046339","GO:1902414","GO:0002291","GO:0050774","GO:0030949","GO:0071321","GO:0007205","GO:0070528","GO:0048009","GO:0046849","GO:2000670","GO:0046325","GO:0070507","GO:0070445","GO:2000064"]},{"accession":"XP_023501060.1","go_terms":["GO:0032434","GO:0006289","GO:0042177","GO:0030433","GO:0000122","GO:0045070","GO:0000715","GO:0016567","GO:0006517","GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0060340","GO:1901097","GO:0006468","GO:1901340","GO:0035458","GO:0000226","GO:0030010","GO:0001828","GO:0001827","GO:1903094","GO:1904153","GO:2000157","GO:0010994","GO:0035973","GO:1904378","GO:0030474","GO:0032815","GO:190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