{"hash":"2025971645570236505","title":"Macromolecular assembly and proteostasis","description":"This cluster centers on the formation and maintenance of macromolecular complexes and the cellular proteome. GO terms highlight assembly of spliceosomal and tubulin complexes, cytoskeletal organization, chaperone-assisted protein complex assembly, protein folding, and ubiquitin-proteasome\u2013mediated quality control, which together suggest a theme of macromolecular assembly and proteostasis. Additional terms for proton transport and vacuolar acidification point to organelle homeostasis that supports proper folding and assembly. Overall, the proteins likely participate in assembling large molecular machines and maintaining protein quality.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_069462808.1","go_terms":["GO:0000245"]},{"accession":"XP_069501907.1","go_terms":[]},{"accession":"XP_069490313.1","go_terms":[]},{"accession":"XP_069507108.1","go_terms":["GO:0007021","GO:0051131","GO:0006457","GO:0071629","GO:0032968","GO:0043622"]},{"accession":"XP_069475885.1","go_terms":[]},{"accession":"XP_069465783.1","go_terms":["GO:1902600","GO:0007035"]}],"graph":[],"all_go_terms":{"GO:0000245":1,"GO:0007021":1,"GO:0043622":1,"GO:0071629":1,"GO:0032968":1,"GO:0006457":1,"GO:0051131":1,"GO:1902600":1,"GO:0007035":1},"recipe_readded":["XP_069480661.1","XP_069486683.1","XP_069474157.1","XP_069468202.1","XP_069502658.1","XP_069504423.1","XP_069490045.1","XP_069491020.1","XP_069469962.1","XP_069488412.1","XP_069487376.1","XP_069486065.1","XP_069503507.1","XP_069490303.1","XP_069503265.1","XP_069476646.1","XP_069469917.1","XP_069506224.1","XP_069495264.1","XP_069493212.1"]}