[{"hash":"1972960227365881934","title":"RNA methylation and ribosome biogenesis","description":"The top GO terms point to RNA processing and translation machinery, including mRNA capping (7-methylguanosine), guanine-N7 methylation, tRNA methylation/modifications, and ribosomal large subunit biogenesis with formation of the translation preinitiation complex. A transcription term and serine/threonine methylation appear, but the dominant signal centers on RNA maturation and ribosome assembly factors; one outlier term (response to cocaine) is likely incidental. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0036265","count":8},{"id":"GO:0006370","count":6},{"id":"GO:0042273","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0006351","count":5}]},{"hash":"1003941361235398529","title":"Mitotic proliferation and ribosome biogenesis","description":"The top GO terms are dominated by cell division, mitotic cell cycle, and mitotic spindle assembly, along with ribosome biogenesis, indicating a core theme of proliferating cells preparing and executing division while producing protein synthesis machinery. The presence of ER-Golgi and Golgi-ER retrograde transport suggests active vesicle trafficking supporting membrane and organelle biogenesis during cell growth, which fits with proliferative and developmental contexts such as multicellular growth and brain development. Overall, the cluster reflects coordinated growth, protein synthesis, and division, with development-related terms providing context. ","confidence":"Medium","size":29,"edges":3,"triangles":1,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0042254","count":7},{"id":"GO:0000278","count":6},{"id":"GO:0006888","count":6},{"id":"GO:0006890","count":6}]},{"hash":"2027652212847801741","title":"Tissue development and morphogenesis","description":"The Top Terms cluster around developmental and morphogenesis processes across multiple tissues (lung, blood vessels, hair follicles, substantia nigra), including differentiation and various morphogenetic events. While there are also signaling and stress-response terms (NF-kappaB regulation, xenobiotic response) and some general cellular processes, the strongest common theme is tissue development and morphological formation, suggesting a broad developmental program rather than a single pathway.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060487","count":5},{"id":"GO:0035690","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0001569","count":5},{"id":"GO:0021762","count":5}]},{"hash":"2095928706981135292","title":"Developmental gene regulation and differentiation","description":"This cluster shows strong enrichment for development-related processes across various tissues (sinoatrial node differentiation, mesenchyme development, myoblast fate determination, stomatal development), indicating a shared theme of developmental programs. The presence of transcription by RNA polymerase II suggests these genes function in transcriptional control driving differentiation, supporting a cohesive developmental module.","confidence":"High","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":26},{"id":"GO:2001038","count":26},{"id":"GO:0048712","count":26},{"id":"GO:0060921","count":25},{"id":"GO:0010374","count":25}]},{"hash":"1976070762111341915","title":"VEGF/PDGF RTK Signaling and Angiogenesis","description":"These proteins show a clear enrichment for vascular endothelial growth factor receptor signaling, platelet-derived growth factor receptor signaling, and promotion of angiogenesis, all stemming from receptor tyrosine kinase activity and downstream ERK cascades. Although a few terms relate to immune or neural development, the dominant theme centers on growth-factor\u2013driven RTK signaling and angiogenesis.","confidence":"Medium","size":29,"edges":15,"triangles":1,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048010","count":13},{"id":"GO:0048008","count":12},{"id":"GO:0001867","count":12},{"id":"GO:0007171","count":10},{"id":"GO:0070374","count":9}]},{"hash":"1694231667663215730","title":"Diverse transmembrane transporters (ions and sugars)","description":"Most frequent GO terms point to transmembrane transport of various substrates, including ions (K+, Na+), xenobiotics, and sugars (galactose, arabinose, fucose). This suggests a cluster of membrane transport proteins with broad substrate scope. While a few terms touch on vesicle loading or nucleocytoplasmic transport, the dominant theme is membrane-associated transport across substrates, supporting a transport-focused cluster label rather than a specific substrate. ","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0006406","count":4},{"id":"GO:0098700","count":4},{"id":"GO:0006004","count":4}]},{"hash":"841154062628587651","title":"Innate Immune Signaling and Leukocyte Activation","description":"The cluster is enriched for GO terms centered on innate immune recognition and leukocyte signaling, including cellular response to fungal origin, stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, and NK cell chemotaxis-related regulation. Developmental terms like lymph vessel morphogenesis and mesonephric duct morphogenesis appear peripheral and do not define the main theme, which is immune sensing and leukocyte activation. This suggests a cohesive immune-related function across the cluster.","confidence":"High","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":29},{"id":"GO:0002223","count":28},{"id":"GO:0060355","count":28},{"id":"GO:0036303","count":28},{"id":"GO:0072287","count":28}]},{"hash":"334740763977285556","title":"Viral entry, replication, and proviral latency","description":"The top GO terms cluster around viral infection and proviral processes\u2014viral entry into the host, DNA integration and recombination, RNA-templated DNA synthesis, and the establishment of integrated proviral latency\u2014often involving host transcription machinery (RNA Pol II). Together, these terms indicate a cohesive theme of viral life cycle events and virus-host genome interactions, despite the lack of network edges.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0051123","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0006278","count":3},{"id":"GO:0039651","count":3}]},{"hash":"739509205759372647","title":"Spliceosome and Translation Initiation Machinery","description":"This cluster is dominated by GO terms for splicing via the spliceosome (cis splicing, splice site recognition, small-subunit processome assembly) and for translation initiation complex formation (preinitiation complex, eIF4F assembly). A note on stress-related mRNA stability links maturation to transcript fate under stress. Together, the proteins appear to function in mRNA processing and the assembly of translation initiation machinery.","confidence":"High","size":29,"edges":262,"triangles":1240,"max_degree":26,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":9},{"id":"GO:0000380","count":9},{"id":"GO:0010610","count":9},{"id":"GO:0045292","count":8},{"id":"GO:0034462","count":8}]},{"hash":"1438238201440454467","title":"RNA processing and miRNA regulation under stress","description":"This cluster is dominated by GO terms related to RNA metabolism\u2014mRNA splicing, mRNA stability, and mRNA decay\u2014as well as miRNA-mediated silencing and miRNA catabolic regulation, especially in the context of stress response. While a few terms touch on lipopolysaccharide response and neuronal activity, the strongest signals tie to RNA processing and post-transcriptional gene regulation, suggesting a coherent theme around RNA metabolism and stress-responsive regulation.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0010610","count":6},{"id":"GO:2000637","count":5},{"id":"GO:0048025","count":5},{"id":"GO:0071222","count":4}]},{"hash":"1786945626166656671","title":"PTM Regulators: Ubiquitination & ADP-ribosylation","description":"These proteins show enrichment for regulation of ubiquitination and for ADP-ribosylation, including negative regulation of protein ubiquitination and K33-linked ubiquitination, plus protein poly-ADP-ribosylation. This points to a shared theme of post-translational modification control. Some other terms (phototropism, gravitropism, telomere maintenance, Rho signaling, renal sodium absorption) are more divergent and may reflect broader multifunctionality or annotation noise, but the dominant signal is PTM regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0032212","count":4},{"id":"GO:0070212","count":4},{"id":"GO:1990390","count":3}]},{"hash":"1858005428876368895","title":"Actin Cytoskeleton Remodeling and Cell Adhesion","description":"The strongest signal among the top GO terms is regulation of actin cytoskeleton remodeling, including stress fiber assembly and substrate adhesion-dependent cell spreading, which together point to coordinated cytoskeletal dynamics driving cell adhesion and migration; other terms like mitotic cell cycle and xenobiotic response appear but cytoskeletal remodeling remains the core theme for this cluster.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":7},{"id":"GO:2000300","count":6},{"id":"GO:0031384","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0043552","count":6}]},{"hash":"2068737811442172719","title":"Biosynthesis of lipids, terpenoids, and sugars","description":"The top GO terms cluster around biosynthetic processes for terpenoids and lipids (geranyl/geranylgeranyl/farnesyl diphosphate, cholesterol, monoterpene, quinone) and also include carbohydrate-related biosynthesis (UDP-N-acetylchitoseglucosamine pathway and glycogen). This suggests a group of proteins involved in diverse biomolecule assembly, with a central theme of biosynthesis rather than a single pathway, hence a label focusing on lipid/terpenoid and sugar biosynthesis is appropriate.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006048","count":7},{"id":"GO:0033386","count":7},{"id":"GO:0015031","count":7},{"id":"GO:0051290","count":7},{"id":"GO:0043693","count":7}]},{"hash":"2225116098850722471","title":"Unknown","description":"The terms span neuromuscular/posture control, synaptic vesicle clustering, bone development and mineralization, interferon responses, glucose transport in response to insulin, endosome-to-plasma membrane trafficking, and immune/biotic stimulus responses. With no edges or clear connectivity among these processes, there isn\u2019t a single cohesive function tying the proteins together, so a unified label is not apparent.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":4},{"id":"GO:0097091","count":4},{"id":"GO:0060349","count":4},{"id":"GO:0035456","count":4},{"id":"GO:0030282","count":4}]},{"hash":"1091677984063862098","title":"DNA replication and repair with oxidative stress response","description":"The top GO terms cluster around genome maintenance and stress handling: DNA recombination, DNA replication, base-excision repair, plus cellular response and redox homeostasis related to hydrogen peroxide. Regulation of mRNA stability and a cell-cycle transition hint at coordinated damage response and proliferation control. Some terms like corneocyte development and renal water transport are less connected and may be incidental. Overall, the cluster centers on genome maintenance and redox balance.","confidence":"High","size":29,"edges":29,"triangles":1,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0007568","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0070301","count":5},{"id":"GO:0006284","count":5}]},{"hash":"967627135837033181","title":"Protein Homeostasis and Cytoskeletal Assembly","description":"The top GO terms cluster around ubiquitin-mediated protein quality control (ubiquitin-dependent ERAD, protein polyubiquitination) and protein assembly (heterotrimerization, homooligomerization), with supporting signals from actin nucleation and processes tied to neuronal projection and skin development. This suggests a cohesive theme of coordinating protein maintenance and complex formation with cytoskeletal remodeling during development.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043588","count":7},{"id":"GO:0007584","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0070208","count":6},{"id":"GO:0051260","count":6}]},{"hash":"162933004515656309","title":"RNA Processing and Translation Regulation","description":"This cluster is dominated by GO terms related to the formation of the translation preinitiation complex, translation reinitiation, and mRNA splicing via the spliceosome, pointing to RNA metabolism and control of gene expression at the RNA level. Additional signals of regulatory phosphorylation and GTPase activity suggest coordinated regulation of protein synthesis with signaling pathways, though a few terms reflect developmental or aging processes that are likely incidental. Overall, the core theme centers on RNA processing and translation regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001731","count":12},{"id":"GO:0002188","count":12},{"id":"GO:0006378","count":12},{"id":"GO:0045292","count":11},{"id":"GO:0007420","count":8}]},{"hash":"315348529231370285","title":"Dopaminergic Signaling and Neural Development","description":"The cluster centers on dopaminergic synaptic transmission and GPCR-cGMP signaling, with related terms for retina development, neuronal proliferation, and behavior (sensitization, eating behavior). This suggests a cohesive module around dopamine-mediated neural signaling and brain development, with behavioral and growth-related connections.","confidence":"Medium","size":29,"edges":249,"triangles":1007,"max_degree":28,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":26},{"id":"GO:0008284","count":26},{"id":"GO:0060041","count":26},{"id":"GO:0008283","count":26},{"id":"GO:0046960","count":25}]},{"hash":"2292972763569604037","title":"Unknown","description":"The top GO terms cover neural development, transcriptional regulation, and general cell biology (including cell cycle, GTPase activity, and stress/immune responses) without a single cohesive theme. This heterogeneity makes it unclear to assign a specific, representative function for the cluster, so a safe Unknown label is appropriate. ","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001403","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0036265","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0050830","count":4}]},{"hash":"1355088121165727354","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":12},{"id":"GO:0051607","count":11},{"id":"GO:0070534","count":10},{"id":"GO:0043029","count":10},{"id":"GO:0061158","count":10}]},{"hash":"1889204087796848691","title":"Cell Signaling and Telomere Maintenance","description":"The proteins here are enriched for signaling pathway terms (Wnt signaling, ephrin receptor signaling, GPCR-related signaling) and regulation of synaptic localization, alongside telomere maintenance and telomeric chromosomal localization. The inclusion of spindle assembly and protein poly-ADP-ribosylation suggests cell-cycle and chromatin-related roles. Together, these points support a label that emphasizes both signaling processes and telomere/genome maintenance.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1901187","count":10},{"id":"GO:1900383","count":10},{"id":"GO:0033280","count":9},{"id":"GO:0032212","count":9},{"id":"GO:0070198","count":9}]},{"hash":"2231951587146827194","title":"Embryonic Development and Morphogenesis","description":"This cluster groups proteins involved in broad embryonic development and tissue formation, with recurring GO terms for mesoderm development, left-right patterning, cartilage morphogenesis, hair follicle morphogenesis, and various organogenesis processes like endocardial cushion EMT and endocrine system development, suggesting a cohesive role in developmental differentiation and morphogenesis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0003198","count":27},{"id":"GO:0003323","count":27},{"id":"GO:0060806","count":27},{"id":"GO:0060972","count":27},{"id":"GO:0060707","count":27}]},{"hash":"988135272499147921","title":"Ubiquitin-Dependent Proteolysis and Innate Antiviral Defense","description":"Top GO terms indicate widespread ubiquitination processes (protein autoubiquitination, ubiquitin-dependent proteolysis, K6-linked ubiquitination, ERAD pathway) and antiviral/innate immune responses (innate immune response, defense against virus, regulation of JNK cascade). This suggests a functional cluster centered on tagging proteins for degradation and modulating immune signaling during antiviral defense. The V(D)J recombination term is related to immune system development, supporting an overall immune-health context, but the core theme remains ubiquitin-mediated regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":22},{"id":"GO:0042787","count":22},{"id":"GO:0045087","count":21},{"id":"GO:0051607","count":21},{"id":"GO:0046328","count":21}]},{"hash":"282357756227065862","title":"Dopaminergic GPCR Signaling","description":"The cluster is dominated by GO terms related to dopaminergic synaptic transmission (GO:0001963) and GPCR signaling pathways coupled to cGMP (GO:0007199), alongside terms about sensitization and eating behavior, which point to dopamine-mediated neural signaling and reward/behavior regulation. While a few terms touch on immune or vascular processes, the strongest signal centers on neuronal dopamine signaling and GPCR activity, supporting a label centered on dopaminergic GPCR pathways.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":26},{"id":"GO:0042755","count":26},{"id":"GO:0001963","count":26},{"id":"GO:0007199","count":26},{"id":"GO:1900134","count":26}]},{"hash":"1734677453965212859","title":"Embryonic Development and Morphogenesis","description":"The top GO terms are strongly centered on developmental processes across multiple tissues (placenta/embryo differentiation, EMT in heart development, cartilage morphogenesis, hair follicle morphogenesis, left\u2013right patterning, endocrine system development), indicating a cohesive theme of embryonic development and tissue morphogenesis. A couple of general cellular processes (ribosomal export, DNA replication initiation) appear as background signals rather than core themes. Confidence: High","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":10},{"id":"GO:0003198","count":10},{"id":"GO:0060806","count":10},{"id":"GO:0003323","count":10},{"id":"GO:0035270","count":10}]},{"hash":"2167879053338009616","title":"Rac/Rho GTPase signaling and actin dynamics","description":"The proteins are enriched for Rac and Rho GTPase signaling terms, with regulation of Rho signaling, filopodium assembly, cell polarity establishment, and membrane localization, all of which converge on actin cytoskeleton remodeling and polarized trafficking. While a couple of outlier terms exist, the dominant pattern points to Rac/Rho-driven cytoskeletal dynamics and membrane organization.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016601","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0006278","count":2},{"id":"GO:0009636","count":2}]},{"hash":"2069597525565691537","title":"Ubiquitin-dependent proteolysis and deubiquitination","description":"The cluster is dominated by GO terms tied to ubiquitin handling: ubiquitin-dependent proteolytic processes and multiple linkage-specific deubiquitinases (K11-, K48-, K6-linked). This suggests proteins involved in ubiquitin cycling and proteasomal degradation rather than a single pathway. Other terms like blood coagulation, fibrinolysis, Wnt signaling, mRNA processing, and glucose response appear but are less cohesive, likely reflecting ancillary connections or multifunctionality. Overall, the shared theme is regulation of protein turnover via ubiquitination and deubiquitination; hence this label captures the core function.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007596","count":7},{"id":"GO:0042730","count":7},{"id":"GO:0016055","count":6},{"id":"GO:0006397","count":6},{"id":"GO:0071333","count":6}]},{"hash":"1388184730418889093","title":"Translation machinery and translational regulation","description":"The cluster centers on core translation processes (GO:0006412) and tRNA aminoacylation (GO:0006431, GO:0006429) with a notable emphasis on regulating translational fidelity (GO:0006450). Protein methylation (GO:0006479) suggests post-translational modulation of translation components, reinforcing the translational theme. Additional terms reflect broader regulatory and stress contexts (mitotic cell cycle, regulation of cytokinesis, NF-kappaB signaling, xenobiotic response, and antibiotic biosynthesis), which may indicate coupling of protein synthesis with growth, division, and defense responses. Overall, the dominant signal is translation and its regulation, with supporting regulatory processes. ","confidence":"Medium","size":28,"edges":22,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006450","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0006479","count":3}]},{"hash":"82266195070822964","title":"Ubiquitination/Deubiquitination Network and NF-\u03baB Regulation","description":"The GO terms show multiple lysine-specific deubiquitination activities (K6, K29, K11, K48) and ubiquitination, indicating a core role for ubiquitin editing; coupled with links to ERAD/proteostasis and immune signaling (TLR3 and NF-\u03baB pathways), the cluster likely centers on ubiquitin-regulatory proteins that modulate proteostasis and inflammatory signaling, including deglycosylation and phosphorylation as supporting modifications.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0044313","count":7},{"id":"GO:0035523","count":7},{"id":"GO:0006517","count":6},{"id":"GO:0034140","count":6},{"id":"GO:1904378","count":6}]},{"hash":"1988155111770450534","title":"Protein quality control and autophagy/ERAD","description":"The cluster shows strong signals for proteostasis-related processes: chaperone-assisted refolding, ubiquitin-dependent ERAD, autophagy, and deubiquitination, indicating a cohesive group of proteins involved in protein quality control and degradation. While DNA replication/transcription terms appear, the recurring proteostasis theme best explains the core functional connection among these proteins.","confidence":"High","size":28,"edges":68,"triangles":14,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0070389","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0006914","count":4}]},{"hash":"210339253357970689","title":"DNA replication, repair, and transcription with cell-cycle signaling","description":"This cluster centers on nuclear processes: DNA replication, DNA repair, and DNA-templated transcription, along with mitotic cell cycle progression, indicating a core role in DNA maintenance and cell division. The presence of regulatory terms for protein stability and phosphorylation, plus signaling pathways like ERK cascade and T cell receptor signaling, suggests integration of these core processes with broader signal transduction. A few terms related to focal adhesion and dendrite morphogenesis introduce some Cytoskeletal/Developmental context, but the dominant theme remains DNA maintenance and cell-cycle regulation linked with signaling. ","confidence":"High","size":28,"edges":30,"triangles":3,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051893","count":26},{"id":"GO:0006260","count":25},{"id":"GO:0006281","count":25},{"id":"GO:0006351","count":25},{"id":"GO:0000278","count":25}]},{"hash":"1142208016407562524","title":"Tissue Morphogenesis and Signaling","description":"The top GO terms point to morphogenesis across several tissues (dendrite, outer ear, mammary gland) with related cellular signaling and responses (prostaglandin, phorbol ester), plus associated immune and DNA repair processes. This suggests a theme centered on developmental morphogenesis coupled with signaling and cellular response pathways, rather than a single, narrow function.","confidence":"Medium","size":28,"edges":226,"triangles":739,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":28},{"id":"GO:1990804","count":28},{"id":"GO:0033598","count":28},{"id":"GO:0002688","count":28},{"id":"GO:0071380","count":28}]},{"hash":"417567668253588208","title":"Angiogenesis and vascular-ECM signaling with immune response","description":"This cluster is dominated by terms tied to new blood vessel formation and vascular cell behavior (angiogenesis, endothelial migration, integrin signaling, ERK cascade, Rho/Ras regulation) and reinforced by ECM remodeling (collagen fibril organization) and immune engagement (complement activation, adaptive immune response). The convergence of vascular development, cell adhesion, and immune signaling suggests a cohesive module for vascular remodeling influenced by immune cues.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0001867","count":12},{"id":"GO:0035023","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0001525","count":12},{"id":"GO:0002250","count":12}]},{"hash":"1150590664041364005","title":"RNA Methylation Enzymes and Biosynthesis","description":"This cluster is strongly enriched for RNA methylation and related methyltransferase activities (tRNA/rRNA methylation, wobble uridine modification, guanine-N7 methylation, and peptidyl-arginine methylation) plus cobalamin and antibiotic biosynthesis, suggesting a group of bacterial enzymes centered on methylation-driven modifications and secondary metabolism. Some terms like nodulation and tellurium ion response appear as peripheral associations but do not outweigh the RNA methylation theme.","confidence":"Medium","size":28,"edges":52,"triangles":37,"max_degree":11,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0009236","count":9},{"id":"GO:0030488","count":8},{"id":"GO:0000122","count":6},{"id":"GO:0031167","count":6},{"id":"GO:0009877","count":6}]},{"hash":"1921375330808856783","title":"Developmental Morphogenesis and Signaling","description":"This cluster is enriched for morphogenesis-related processes such as dendrite morphogenesis, outer ear morphogenesis, and mammary gland epithelial cell proliferation, and also shows peptide- and lipid-mediated signaling responses (prostaglandin E stimulus, phorbol ester response). While DNA repair and cell-cycle-related terms appear, the dominant signal points toward developmental growth and signaling pathways governing tissue morphogenesis and cellular responses, rather than a single, narrow function. ","confidence":"Medium","size":28,"edges":277,"triangles":1907,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007100","count":24},{"id":"GO:0048813","count":21},{"id":"GO:1990804","count":21},{"id":"GO:0033598","count":21},{"id":"GO:0002688","count":21}]},{"hash":"1446024531413861172","title":"Neuronal synaptic vesicle regulation","description":"The dominant terms center on regulation of synaptic vesicle exocytosis and endocytosis, plus neural development (substantia nigra development). This points to roles in neuronal vesicle trafficking and synaptic signaling, with supporting hints from GTPase regulation and cytoskeletal remodeling terms. Overall, the cluster appears to capture proteins involved in neuronal vesicle dynamics and neural development.","confidence":"High","size":28,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":4},{"id":"GO:0021762","count":4},{"id":"GO:0032729","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0071803","count":4}]},{"hash":"1966472998657378742","title":"Ribosome biogenesis and translation","description":"The GO terms are dominated by translation, ribosome biogenesis, and rRNA maturation (including SSU/LSU processing and pseudouridine synthesis), with terms for formation of translation preinitiation complexes. This points to proteins involved in ribosome assembly and the translation machinery, with a few incidental RNA processing/splicing terms. ","confidence":"High","size":28,"edges":365,"triangles":2967,"max_degree":27,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0042254","count":7},{"id":"GO:0000462","count":6},{"id":"GO:0031118","count":4},{"id":"GO:0031120","count":4}]},{"hash":"1276325445144833120","title":"Neural and sensory development with immune signaling","description":"The cluster combines neural/sensory development terms (nervous system development, visual perception, retinal morphogenesis, forebrain proliferation) with immune-related and detox responses (lipopolysaccharide response, complement activation, xenobiotic response) and an ERK signaling motif, suggesting proteins involved in vertebrate organogenesis and signaling crosstalk.","confidence":"Medium","size":28,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0007601","count":4}]},{"hash":"241099710721292811","title":"Amino acid and cofactor biosynthesis","description":"This cluster shows enrichment for multiple biosynthetic processes (lysine, tyrosine, biotin) and a heme precursor (protoporphyrinogen IX), plus central carbon metabolism (oxaloacetate) and fatty acid homeostasis. The common thread is biosynthesis and core metabolism, with a few outliers (Notch signaling, antibiotic response) likely due to annotation noise. Therefore, a label emphasizing biosynthetic and metabolic pathways fits best.","confidence":"Medium","size":28,"edges":36,"triangles":61,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0006782","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0006107","count":4}]},{"hash":"67182283225823734","title":"Skin ECM Remodeling and Angiogenic Signaling","description":"This cluster centers on extracellular matrix organization (collagen fibril organization, collagen biosynthesis) and cell\u2013matrix signaling (integrin pathway, BMP response) with links to angiogenesis (VEGF signaling). The presence of keratinocyte differentiation and Notch processing suggests a skin/epidermal context. Together, these GO terms imply coordinated ECM remodeling coupled with differentiation and vascular signaling, rather than a single isolated process.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0030216","count":10},{"id":"GO:0007220","count":10},{"id":"GO:0010042","count":10},{"id":"GO:0034612","count":10}]},{"hash":"733449405558644198","title":"Neural development and myelination","description":"The top terms point strongly to nervous system development, including neuroblast development, Schwann cell differentiation, and myelination, suggesting a cluster of proteins involved in neural differentiation and peripheral nerve myelination. Other terms related to broader developmental processes (wing disc pattern formation, epidermis development) and signaling (phosphatidylinositol dephosphorylation) appear less central, but do not override the neural/nerve-glia theme. Overall, the cluster seems to reflect nervous system development with a focus on myelinating glia.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0007568","count":3},{"id":"GO:0046856","count":3},{"id":"GO:0035222","count":3}]},{"hash":"515582407639327312","title":"Rho-regulated actin remodeling and endocytosis","description":"The top GO terms cluster around actin filament organization, crosslinking, and cortical patch assembly, along with endocytosis and regulation of Rho-GTPase signaling. This points to a cohesive module where Rho-family\u2013driven actin remodeling facilitates membrane trafficking via endocytosis, with some membrane/immune-related signals possibly reflecting broader membrane dynamics. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":5},{"id":"GO:0000147","count":3},{"id":"GO:0046513","count":3},{"id":"GO:0035023","count":2},{"id":"GO:0043547","count":2}]},{"hash":"111525029289150965","title":"Developmental differentiation and cell cycle regulation","description":"The top GO terms point to tissue-specific differentiation (neuron projection development, lens fiber cell differentiation, skin development) and broad multicellular organism development, alongside core cell cycle processes (mitotic cell cycle, anaphase-promoting complex-dependent catabolic process). There is also enrichment for actin cytoskeleton remodeling (Arp2/3-mediated actin nucleation) and GPCR signaling, which commonly accompany development and cell division. Overall, these proteins likely participate in developmental programs involving tissue differentiation with coordinated cell cycle control and cytoskeletal dynamics.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031175","count":5},{"id":"GO:0070306","count":5},{"id":"GO:0007568","count":4},{"id":"GO:0043588","count":4},{"id":"GO:2000601","count":4}]},{"hash":"150204772676579503","title":"Dopaminergic Synaptic Signaling and Neural Behavior","description":"The cluster is enriched for terms tied to neural signaling and behavior, notably dopaminergic synaptic transmission, GPCR signaling coupled to cGMP, and brain-regulated activities such as learning, eating behavior, and sensitization. Additional terms like heat generation and renin regulation fit within broader neural control of physiological responses, supporting a cohesive theme of neural communication and behavioral regulation rather than a single metabolic pathway. Confidence: High","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":15},{"id":"GO:0019835","count":15},{"id":"GO:0008542","count":15},{"id":"GO:0040015","count":15},{"id":"GO:0046960","count":14}]},{"hash":"863557824456651867","title":"Spliceosome-Driven mRNA Processing and Regulation","description":"Dominant GO terms center on mRNA splicing via the spliceosome, including splice-site recognition and both positive and negative regulation of splicing, plus related RNA processing steps like small-subunit processome assembly and regulation of mRNA stability in stress. This pattern points to a cluster of splicing factors and RNA processing regulators rather than other RNA-centric processes.","confidence":"High","size":28,"edges":291,"triangles":1533,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":21},{"id":"GO:0045292","count":20},{"id":"GO:0048026","count":18},{"id":"GO:0048025","count":18},{"id":"GO:0031047","count":18}]},{"hash":"583218782661063025","title":"Eye and craniofacial development","description":"Dominant terms point to ocular and craniofacial developmental programs: camera-type eye development, lens fiber cell differentiation, visual perception, and midbrain and palate development. While a few terms (amelogenesis, collagen catabolic process, blood coagulation, complement activation) are less obviously connected, they appear as peripheral annotations, whereas the core theme is eye/craniofacial development.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0007601","count":9},{"id":"GO:0043010","count":8},{"id":"GO:0070306","count":8},{"id":"GO:0030901","count":8}]},{"hash":"1667755883759474837","title":"Immune and vascular development regulators","description":"This cluster shows enrichment for both immune functions (adaptive and innate immune responses, neutrophil chemotaxis) and cardiovascular development (heart development, smooth muscle cell migration). The presence of Rho/GTPase regulation and cytoskeletal signaling suggests roles in cell migration and structural remodeling common to immune cell trafficking and vascular/heart development, with retinoic acid response reinforcing developmental context. Overall, the proteins appear to link immune signaling with vascular/heart development processes.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0071300","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0035023","count":3}]},{"hash":"1548663768221858894","title":"Muscle development and calcium signaling","description":"This cluster is driven by GO terms linking muscle formation processes (multicellular organism development, positive regulation of myoblast fusion) with calcium signaling relevant to muscle cells (release of sequestered calcium from the sarcoplasmic reticulum, regulation of calcium release). The presence of cell-shape regulation and transcription/DNA-binding regulation suggests coordinated gene expression during differentiation. Some terms like xenobiotic response and angiogenesis are present but appear peripheral to the core muscle/Calcium theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:1901741","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0014808","count":3},{"id":"GO:0016525","count":3}]},{"hash":"771635939036842","title":"RNA Methylation and Modification","description":"The top GO terms converge on methylation-related activities: tRNA wobble uridine modification, mRNA capping, RNA guanine-N7-methylation, and peptidyl-arginine methylation, indicating a core theme of RNA and protein methylation processes. Some plant-specific processes (chlorophyll biosynthesis, nodulation) appear but do not override the central methylation signal. The cluster most plausibly represents RNA methylation machinery with ancillary plant-related functions, so the name reflects the dominant function. ","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002098","count":3},{"id":"GO:1901052","count":3},{"id":"GO:0006370","count":3},{"id":"GO:0036068","count":3},{"id":"GO:0016049","count":3}]},{"hash":"1369794560672945756","title":"Ubiquitin-Dependent Innate Antiviral Defense","description":"The cluster centers on ubiquitin-dependent processes (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, ERAD) together with innate immune and antiviral responses (innate immune response, defense against virus, TNF/NF-\u03baB signaling). This suggests a cohesive role in regulating antiviral innate immunity via ubiquitin tagging and proteasomal degradation, as well as related inflammatory signaling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0045087","count":18},{"id":"GO:0051092","count":17},{"id":"GO:0051607","count":17},{"id":"GO:1903265","count":17}]},{"hash":"2126528657693228104","title":"Neural and B-cell signaling regulators","description":"This cluster includes GO terms related to Rho/GTPase signaling regulation and synaptic processes (glutamatergic transmission, vesicle maturation, and plasticity), alongside B cell receptor signaling and its positive regulation, suggesting proteins that modulate signal transduction in both neural synapses and immune signaling contexts.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0031914","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0032425","count":4}]},{"hash":"558816799560823458","title":"Epithelial Tight Junction and Immune Signaling","description":"This cluster is dominated by terms tied to epithelial barrier function (bicellular tight junction assembly, regulation of tight junctions, transcytosis) and immune signaling pathways (EGFR signaling, T cell receptor signaling, innate immune response), suggesting proteins that integrate barrier integrity with immune communication. While a few terms (osteoclast development regulation, Ras signaling) point to broader signaling cross-talk, the core theme centers on epithelial barrier regulation coupled with immune signaling. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":5},{"id":"GO:0007173","count":4},{"id":"GO:0050852","count":4},{"id":"GO:2001205","count":4},{"id":"GO:1903348","count":4}]},{"hash":"1699694333335854092","title":"Rho-driven signaling and cell migration","description":"The top GO terms center on regulation of Rho signaling and cell movement, with related pathways such as GPCR signaling, EGF response, and thrombin signaling, plus endocytic processes like pinocytosis. Together, they point to signaling events that remodel the cytoskeleton and drive motility and membrane trafficking. Some peripheral terms (myelin maintenance, B cell homeostasis) are less central to this core theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0016477","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0007205","count":3}]},{"hash":"1850539228109157842","title":"DNA Transcription Regulation and Nucleotide Biosynthesis","description":"The cluster centers on regulation of DNA-templated transcription and cell-cycle-related nucleotide metabolism (pyrimidine ribonucleotide biosynthetic processes, dUTP/dITP catabolism) with an instance of positive regulation of sister chromatid cohesion, suggesting a theme of coordinating gene expression with DNA replication and nucleotide supply; eye morphogenesis and hemopoiesis terms appear less central to the core function.","confidence":"Medium","size":28,"edges":27,"triangles":0,"max_degree":27,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0048050","count":2},{"id":"GO:0060216","count":2},{"id":"GO:0048048","count":2},{"id":"GO:0035863","count":1}]},{"hash":"1744375899509544541","title":"Embryonic development and morphogenesis","description":"This cluster is enriched for GO terms spanning embryogenesis and tissue morphogenesis across multiple lineages\u2014EMT in heart development, mesoderm formation, left-right patterning, cartilage and hair follicle morphogenesis, placental and endocrine development, and trophoblast differentiation\u2014indicating a shared role in shaping developing tissues and organs rather than a single pathway.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0003198","count":15},{"id":"GO:0003323","count":15},{"id":"GO:0060806","count":15},{"id":"GO:0060972","count":15},{"id":"GO:0060707","count":15}]},{"hash":"2089968235729152692","title":"Embryonic organogenesis and neural differentiation","description":"This cluster centers on developmental morphogenesis across multiple organs (craniofacial structures like the roof of the mouth, thyroid, pituitary, mesonephric duct) and neural differentiation (dopaminergic neuron differentiation). The concurrent presence of RNA polymerase II transcriptional activity terms suggests regulation during embryogenesis. Together, these terms point to a theme of early development and organ formation, including neural lineages.","confidence":"High","size":28,"edges":67,"triangles":31,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":18},{"id":"GO:0061551","count":17},{"id":"GO:0007338","count":17},{"id":"GO:0000122","count":17},{"id":"GO:0006366","count":16}]},{"hash":"692591458989964338","title":"Adaptive immune activation and lymphoid development","description":"The dominant GO terms describe activation and differentiation of lymphocytes (T cells, NK T cells, B cells) and hematopoiesis, with signaling through small GTPases, Ras/Rho pathways, and IGF receptor signaling. These connected functions point to a cohesive theme of adaptive immune responses and lymphoid development, with hyaluronan metabolism possibly reflecting extracellular matrix interactions during immune processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002291","count":17},{"id":"GO:0030212","count":17},{"id":"GO:0035023","count":16},{"id":"GO:0001865","count":14},{"id":"GO:0007264","count":14}]},{"hash":"164814428461504972","title":"Plant arabinogalactan protein glycosylation and root hair development","description":"The top GO terms cluster around arabinogalactan protein metabolism and various glycosylation processes (including O-linked hydroxyproline glycosylation and Lewis a epitopes), as well as development-related terms such as root hair formation, seed coat mucilage production, and cell adhesion. This suggests a cohesive theme of plant cell-surface glycoprotein function and cell-wall remodeling during development, with AGP glycosylation being a central feature.","confidence":"High","size":28,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":9},{"id":"GO:0030311","count":8},{"id":"GO:0001744","count":8},{"id":"GO:0042248","count":8},{"id":"GO:0048354","count":8}]},{"hash":"969220490717371456","title":"Dopaminergic signaling in reward and feeding","description":"The top GO terms cluster around dopaminergic synaptic transmission, sensitization, and eating behavior, all anchored by GPCR signaling linked to cGMP. This points to a dopamine-driven neural signaling module involved in reward, learning, and feeding. Some outlier terms exist, but the dominant signal supports a dopaminergic feeding/reward theme. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":28},{"id":"GO:0042755","count":28},{"id":"GO:0001963","count":28},{"id":"GO:0007199","count":28},{"id":"GO:1900134","count":28}]},{"hash":"878691586101404432","title":"Rap GTPase Signaling and Nuclear Transport","description":"This cluster centers on Rap protein signal transduction and regulation of GTPase activity, together with intracellular transport and transcription-related processes, suggesting a cohesive theme of small GTPase\u2013driven signaling influencing trafficking and nuclear functions. Some terms appear as outliers (developmental pathways), but the core enrichment supports a Rap GTPase\u2013driven theme. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006886","count":3},{"id":"GO:0032486","count":3},{"id":"GO:0090630","count":3}]},{"hash":"2107752274046955771","title":"Neuronal development and synaptic signaling","description":"The cluster centers on terms tied to neural connectivity and synaptic organization, including axonal fasciculation, synapse assembly, synaptic plasticity, and signaling pathways such as Wnt, ephrin receptor, and Rac/Rho regulation, which together reflect neuronal development and synaptic signaling. The auditory perception term suggests involvement in the visualized tissues or systems like the auditory pathway, while the innate immune term may reflect CNS immune interactions but is less central to the core theme. Overall, the dominant signal points to neurons coordinating connectivity and synaptic function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007605","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0035023","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0016055","count":3}]},{"hash":"890177635571845660","title":"Ribosome biogenesis and translation machinery","description":"The cluster is dominated by GO terms for translation (cytoplasmic and general), ribosome biogenesis, ribosomal large subunit export from the nucleus, and tRNA modification, pointing to core ribosome assembly and protein synthesis functions. Secondary terms related to cell cycle/division may reflect growth needs but do not override the primary ribosome/translation signal.","confidence":"High","size":27,"edges":17,"triangles":0,"max_degree":7,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:1903833","count":8},{"id":"GO:0002181","count":8},{"id":"GO:0042254","count":7},{"id":"GO:0000055","count":5}]},{"hash":"415133987151591269","title":"DNA damage response and p53-mediated apoptosis","description":"The cluster is enriched for DNA-templated transcription, DNA repair, mitotic cell cycle, and especially p53-mediated apoptotic signaling terms, pointing to a core role in DNA damage response and cell fate decisions. Some development-related terms (retina vasculature, hepatocyte differentiation) may reflect broader transcriptional regulation but do not override the main theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0061298","count":7},{"id":"GO:0042220","count":6},{"id":"GO:0035902","count":6},{"id":"GO:0070365","count":6}]},{"hash":"568590646553258331","title":"Adaptive immune signaling and lymphocyte development","description":"Most terms cluster around adaptive immune signaling: T cell receptor signaling, B cell maturation, NK T cell differentiation, and cytokine responses (IL-4, IL-7). These define signaling and differentiation processes in lymphocytes, complemented by related migratory and developmental pathways (Wnt, ephrin receptor signaling). Together, this set represents immune cell activation and development rather than a housekeeping process.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":17},{"id":"GO:0090263","count":16},{"id":"GO:0043552","count":16},{"id":"GO:0048013","count":16},{"id":"GO:0050852","count":16}]},{"hash":"781010289572440503","title":"Wnt/Hippo signaling and epithelial differentiation","description":"This cluster is dominated by GO terms for canonical Wnt signaling and Hippo signaling, plus keratinocyte differentiation, which together point to a core theme of signaling pathways governing cell fate and proliferation in epithelial contexts. While there are additional signals related to apoptosis, neuronal morphogenesis, and immune signaling (TCR and GM-CSF), the strongest, most coherent signal is Wnt/Hippo\u2013driven regulation of epithelial differentiation and growth control.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090263","count":19},{"id":"GO:0030216","count":18},{"id":"GO:0060044","count":18},{"id":"GO:0006915","count":18},{"id":"GO:0035329","count":18}]},{"hash":"1831563682993022396","title":"Reproductive hormone biosynthesis and female development","description":"This cluster shows strong representation of GO terms related to prostaglandin biosynthesis, cholesterol/steroid metabolism (androgen, vitamin D), and reproductive development (sex differentiation, female genitalia development, parturition). The convergence on both prostaglandin and steroid pathways suggests involvement in pregnancy-related regulation and female reproductive biology.","confidence":"High","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":21},{"id":"GO:0060137","count":20},{"id":"GO:0010164","count":20},{"id":"GO:0030540","count":20},{"id":"GO:0042369","count":20}]},{"hash":"1276446998495054969","title":"Sex differentiation and steroid metabolism","description":"The top GO terms overwhelmingly cluster around reproductive development and hormone pathways\u2014maternal processes in parturition, female genitalia development, sex differentiation, and androgen and cholesterol metabolism\u2014suggesting a group of proteins involved in sex development and steroid hormone biosynthesis/metabolism. A few other terms (response to metals or nematodes) appear peripheral and do not define the core theme. ","confidence":"High","size":27,"edges":43,"triangles":28,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060137","count":26},{"id":"GO:0010164","count":26},{"id":"GO:0030540","count":26},{"id":"GO:0042369","count":26},{"id":"GO:0008209","count":26}]},{"hash":"1281817036397371262","title":"Ribosome Biogenesis and Translation","description":"The top terms cluster around ribosome biogenesis (including both subunits and their export from the nucleus), cytoplasmic translation, and related translation processes, with tRNA modification aligning with the protein-synthesis machinery. While some cell division-related terms appear, the dominant theme is assembly and function of the ribosome and the translation apparatus, supporting a cohesive label focused on protein synthesis machinery.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0000055","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0000747","count":4}]},{"hash":"1441507517073540748","title":"Vertebrate Eye and Brain Development","description":"Based on top GO terms, the cluster centers on vertebrate embryonic development of neural and ocular structures (eye morphogenesis, camera-type eye development; midbrain and habenula development; peripheral nervous system neuron development) and includes transcriptional regulation of RNA Pol II. This suggests a set of transcription factors coordinating eye and brain morphogenesis during vertebrate development.","confidence":"High","size":27,"edges":99,"triangles":48,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0006366","count":11},{"id":"GO:0048935","count":11},{"id":"GO:0090009","count":11},{"id":"GO:0048048","count":10}]},{"hash":"1540574010581198257","title":"Cofactor and antibiotic biosynthesis","description":"The top GO terms cluster around biosynthesis of vitamins and cofactors (antibiotic biosynthesis; menaquinone, phylloquinone, biotin, and cobalamin biosynthesis). There are also related metabolic processes (fatty acid beta-oxidation, phenylacetate and valine catabolism) and a xenobiotic response, suggesting a bacterial module focused on cofactor/secondary metabolite production with linked metabolism.","confidence":"High","size":27,"edges":93,"triangles":121,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0009234","count":8},{"id":"GO:0042372","count":8},{"id":"GO:0010124","count":5},{"id":"GO:0006574","count":5}]},{"hash":"907362898813881919","title":"Fertilization and Early Development Gene Regulation","description":"The cluster shows enrichment for DNA-templated transcription, transcription by RNA polymerase II, and DNA replication, which points to core cell-cycle and gene-expression processes. The presence of GO terms related to sperm binding to the zona pellucida and polyspermy prevention suggests a reproductive/ fertilization component, aligning with early developmental regulation. Other terms like infection-structure formation and lymphangiogenesis hint at broader developmental roles, but the strongest signal lies in transcription/replication coupled with fertilization-related functions. Confidence: Medium","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0001946","count":2}]},{"hash":"2065607041351801957","title":"Nuclear gene expression and cell cycle control","description":"The top GO terms point to nuclear processes: DNA-templated transcription, DNA replication, mRNA export, and cell division, with supporting links to microtubule severing and protein homooligomerization. This suggests a cluster of proteins involved in genome expression and progression through the cell cycle, rather than extracellular signaling. Some terms like sensory perception of smell and certain signaling annotations appear less coherent with this core theme, likely reflecting annotation noise, but do not override the dominant nuclear/cell-cycle signal.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0090261","count":7},{"id":"GO:0006260","count":7},{"id":"GO:0006406","count":7},{"id":"GO:0051301","count":7}]},{"hash":"1907915883028269453","title":"DNA replication and mitotic cell cycle","description":"The dominant GO terms are mitotic cell cycle, DNA replication, DNA-templated transcription, and DNA repair, pointing to a core function in DNA maintenance and cell cycle progression. The additional terms related to dendrite morphogenesis, nervous system development, ERK signaling, and T cell receptor signaling appear as secondary or pleiotropic associations, but do not override the central DNA-related theme.","confidence":"Medium","size":27,"edges":3,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":24},{"id":"GO:0006260","count":23},{"id":"GO:0006351","count":20},{"id":"GO:0006281","count":19},{"id":"GO:0048813","count":19}]},{"hash":"2238724523182053453","title":"Neuronal vesicle trafficking and GPCR endocytosis","description":"The terms point to neuronal membrane trafficking: synaptic vesicle budding and GPCR internalization, together with adult locomotory behavior. Additional terms (ER-to-Golgi transport, mitochondrial fission, filopodium regulation) reflect broader cellular trafficking connected to neurite dynamics. Altogether, the cluster seems to center on neuronal vesicle dynamics and receptor endocytosis.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0008344","count":7},{"id":"GO:1901998","count":7},{"id":"GO:0016185","count":7},{"id":"GO:0016477","count":5},{"id":"GO:0002031","count":5}]},{"hash":"583042188371217643","title":"Kidney morphogenesis and organ identity regulation","description":"This cluster\u2019s top terms center on metanephros morphogenesis and maintenance of organ identity, alongside regulatory processes like negative Wnt signaling, cell migration, apoptosis, and nuclear import. Together, these imply a developmental program governing organ formation and patterning, with kidney development as a core facet, supported by signaling and cell-survival controls.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0016477","count":12},{"id":"GO:0043547","count":12},{"id":"GO:0015991","count":12},{"id":"GO:0006607","count":12},{"id":"GO:0090090","count":11}]},{"hash":"1920150301777616706","title":"Axon growth and Schwann cell development","description":"The GO terms cluster around axonogenesis and regeneration, notably positive regulation of axon extension and axon regeneration, plus Schwann cell development and sensory neuron axon fasciculation. Receptor clustering and substrate adhesion-dependent spreading emphasize axon\u2013glia/ECM interactions at growth and pathfinding. The presence of angiogenesis and Wnt signaling modulation suggests supportive signaling environments for nerve repair. This combination points to a cohesive nerve growth/repair program.","confidence":"High","size":27,"edges":36,"triangles":47,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048680","count":12},{"id":"GO:0034446","count":12},{"id":"GO:0097155","count":12},{"id":"GO:0043113","count":12},{"id":"GO:0014044","count":12}]},{"hash":"794895709115141972","title":"Placental development and mitochondrial apoptosis","description":"The GO terms show maternal/placental processes (parturition and placenta development) alongside mitochondrial outer membrane permeabilization, indicating apoptosis. Additional terms like protein ubiquitination and Rho/GTPase regulation suggest signaling and remodeling activities that commonly participate in placental tissue development. Although some terms are less connected (DNA integration, bone resorption), the strongest coherent theme centers on placental biology and apoptosis signaling.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060137","count":10},{"id":"GO:0097345","count":9},{"id":"GO:0001893","count":9},{"id":"GO:1903547","count":9},{"id":"GO:0015074","count":7}]},{"hash":"821114246020251833","title":"Ribosome Biogenesis and Translation Initiation","description":"This cluster is dominated by GO terms for ribosome assembly and protein synthesis, including ribosome biogenesis, cytoplasmic translation, formation of the translation preinitiation complex, and regulation of translational initiation, plus IRES-dependent translational initiation. While a few terms touch on cell division or neuron development, the strongest signals are translation-related, suggesting proteins involved in ribosome biogenesis and initiation of translation.","confidence":"High","size":27,"edges":204,"triangles":665,"max_degree":25,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":8},{"id":"GO:0031175","count":8},{"id":"GO:0000278","count":7},{"id":"GO:0000281","count":7},{"id":"GO:0051301","count":7}]},{"hash":"1114639982030748794","title":"Calcium-regulated cardiac muscle contraction","description":"The top GO terms show a strong focus on calcium ion detection and calcium-dependent regulation of muscle contraction, especially in cardiac muscle (e.g., detection of calcium ion, regulation of calcium release, cardiac muscle contraction, positive regulation of heart contraction, skeletal muscle fiber development). These collectively point to a function centered on calcium-mediated control of cardiac muscle force, with some broader developmental terms likely reflecting multi-function proteins. Therefore, this label captures the core theme of the cluster.","confidence":"High","size":27,"edges":18,"triangles":1,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":14},{"id":"GO:0048741","count":13},{"id":"GO:0010881","count":13},{"id":"GO:0098735","count":13},{"id":"GO:0005513","count":13}]},{"hash":"1698007328115448299","title":"Neural development and synaptic signaling cluster","description":"The GO terms are dominated by neural-related functions such as axonogenesis, excitatory postsynaptic potential, and visual perception, pointing to neural development and synaptic signaling; other terms like heart development and muscle activity indicate broader neuromuscular development context, but the core theme remains neural.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":11},{"id":"GO:0007601","count":11},{"id":"GO:0046826","count":11},{"id":"GO:0006351","count":11},{"id":"GO:0060079","count":10}]},{"hash":"2043892724707751781","title":"Integrin-Mediated Signaling in Epidermal and Vascular Development","description":"The top GO terms cluster around integrin-mediated cell adhesion and signaling, with associated pathways such as VEGF signaling, BMP response, Notch processing, and keratinocyte differentiation. This suggests a functional module where adhesion cues via integrins drive signaling cascades that coordinate epidermal (keratinocyte) differentiation and vascular development, rather than isolated adhesion or differentiation events.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:1900748","count":10},{"id":"GO:0032331","count":10},{"id":"GO:0055114","count":10},{"id":"GO:0033631","count":9},{"id":"GO:0034612","count":8}]},{"hash":"1016159346588261151","title":"Rho signaling and cell cycle regulation","description":"The top GO terms point to a mix of cytoskeletal signaling (regulation of Rho signaling, dendritic spine morphogenesis, integrin-mediated adhesion, ephrin signaling, glycine receptor clustering) and core cell cycle processes (DNA replication, mitotic G2 checkpoint, meiotic cell cycle). This suggests the cluster groups proteins involved in both signal transduction that governs cytoskeletal organization and those governing cell division, indicating a connected theme of signaling coordinating cytoskeleton and proliferation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0007095","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0051321","count":5},{"id":"GO:0048013","count":5}]},{"hash":"2040650400822044068","title":"Neural crest migration and nervous system development","description":"The top GO terms cluster strongly around nervous system development, including trigeminal nerve organization, ventral trunk neural crest migration, myelination, and Roundabout (ROBO) signaling, all of which point to neural patterning and axon guidance. While there are immune-related terms like complement activation and innate immune response in the list, they are less central to the cluster\u2019s core theme; overall, the terms cohere around neural crest\u2013driven nervous system development and peripheral nerve formation.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":14},{"id":"GO:0045087","count":12},{"id":"GO:0035385","count":12},{"id":"GO:0042552","count":12},{"id":"GO:0014068","count":12}]},{"hash":"618983362457152546","title":"Fatty acid metabolism and seed development","description":"The cluster shows strong enrichment for long-chain fatty acid metabolic and biosynthetic processes, fatty acid import, and related lipid metabolism terms, suggesting a core theme of lipid synthesis and utilization. The presence of seed-related terms like seed coat development and positive regulation of seed germination indicates a plant seed biology context, reinforcing the lipid-centric role in energy storage and germination. Some outlier terms (e.g., lipoteichoic acid biosynthesis, bile acid metabolism) may reflect annotation noise or cross-species data, but the prominent pattern centers on fatty acid metabolism linked to seed biology.","confidence":"High","size":27,"edges":314,"triangles":2141,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0010124","count":20},{"id":"GO:1902987","count":20},{"id":"GO:0008206","count":20},{"id":"GO:0001676","count":20},{"id":"GO:0010214","count":20}]},{"hash":"2187465890037477075","title":"Neural signaling and behavior regulation","description":"Top terms are dominated by neural and behavioral processes, including vocalization behavior, sensory perception of sound, and regulation of grooming behavior, suggesting a group of proteins involved in neural signaling and behavior control. Additional terms on receptor clustering and GTPase activation indicate synaptic organization and signal transduction, while Golgi localization points to trafficking of receptors. A few terms (endothelial barrier, NOD2 signaling) are less clearly connected; overall, the cluster centers on neuronal signaling and behavioral regulation.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0071625","count":15},{"id":"GO:0090557","count":14},{"id":"GO:0043113","count":13},{"id":"GO:2000821","count":13},{"id":"GO:0007605","count":13}]},{"hash":"613963453610810875","title":"Embryonic development signaling and morphogenesis","description":"The top GO terms cluster around core developmental processes across tissues: myoblast fusion, axial mesoderm formation, and corpus callosum development, with supporting BMP signaling and Rho/STAT pathway regulation. Additional terms highlight cell-matrix adhesion and IL-27\u2013mediated immune signaling, suggesting signaling-driven tissue differentiation and morphogenesis with some immune interaction during development. ","confidence":"Medium","size":27,"edges":273,"triangles":1481,"max_degree":26,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007520","count":21},{"id":"GO:0035023","count":20},{"id":"GO:0070106","count":17},{"id":"GO:0035745","count":17},{"id":"GO:0042517","count":17}]},{"hash":"1162905758417649092","title":"Unknown","description":"The top GO terms are highly diverse, including translation, DNA replication, various metabolic pathways (fatty acid and amino acid catabolism, glycogen and fatty-acyl-CoA biosynthesis), development, and even ascaroside biosynthesis, with no observed edges linking members. There isn\u2019t a single cohesive function tying these proteins together, so the cluster is best labeled Unknown.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0033539","count":2},{"id":"GO:0009791","count":2},{"id":"GO:0006574","count":2}]},{"hash":"1004189194431066220","title":"Temperature-Driven Pain and Coagulation Response","description":"The top GO terms cluster around sensory perception of pain and temperature-related processes (sensory pain, diet-induced thermogenesis, cellular response to temperature stimulus), and strongly vascular/hemostatic functions (vasoconstriction, platelet activation, blood coagulation, inflammatory response). This implies a theme where temperature/pain signals are coupled with vascular regulation and coagulation/inflammation. Some terms like visual learning and GTPase regulation may be secondary or annotation noise, but the core pattern points to temperature- and pain-associated vascular and inflammatory responses. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0045907","count":9},{"id":"GO:0042391","count":9}]},{"hash":"1675695448750930465","title":"Actin Cytoskeleton Remodeling and Cell Spreading","description":"This cluster is dominated by GO terms for actin cytoskeleton organization and assembly of filopodia, lamellipodia, and ruffles, plus positive regulation of substrate adhesion-dependent cell spreading, indicating proteins that drive actin-driven protrusions and cell adhesion during migration. The presence of stress fiber assembly and related trafficking terms (Golgi ribbon formation, endosome-to-Golgi transport) suggests coordinated cytoskeletal remodeling with vesicular transport in polarized or migrating cells.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:1900026","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0051496","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0097178","count":3}]},{"hash":"916457154974869791","title":"Neuronal development and synaptic vesicle regulation","description":"Top terms point to brain development, synaptic vesicle exocytosis, and axon guidance, with supporting vesicle transport and growth processes. This pattern suggests a cluster of proteins involved in neural development and vesicle trafficking.","confidence":"Medium","size":27,"edges":93,"triangles":45,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":10},{"id":"GO:0031384","count":9},{"id":"GO:0010796","count":9},{"id":"GO:2000300","count":8},{"id":"GO:0035385","count":8}]},{"hash":"1723745285153596151","title":"Neural development and synaptic signaling","description":"Top terms show a clear emphasis on nervous system development, myelination, synapse assembly, neurotransmitter secretion, and axon guidance (Roundabout signaling), with supporting cytoskeletal dynamics via Rho signaling. Although immune and heart-related terms appear, the predominant theme is neural development and synaptic function, so this label captures the cluster\u2019s core biology.","confidence":"High","size":27,"edges":5,"triangles":0,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":9},{"id":"GO:0050852","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0035385","count":8}]},{"hash":"772129770063103141","title":"Rho-GTPase Signaling and Cell Migration","description":"The strongest signals are from regulation of Rho protein signal transduction, positive regulation of GTPase activity, and fibroblast migration, which together point to cytoskeletal remodeling and cell movement driven by Rho-family pathways. Additional terms like multicellular organism development and immune responses suggest broader roles, but the core theme centers on Rho/GTPase\u2013mediated motility and remodeling.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0010761","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0000055","count":3}]},{"hash":"633171009120514604","title":"Neuroimmune Signaling and Development","description":"This cluster mixes innate immune signaling terms (innate immune response, LPS signaling, dsRNA response, NF-kappaB regulation, interferon-beta production) with neural development terms (corpus callosum development, axonal fasciculation, RTK signaling, collagen fibril organization). The combination suggests proteins involved in neuroimmune interactions that influence neural development and ECM remodeling, e.g., microglia/astrocyte-mediated signaling affecting axon guidance. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0007169","count":6},{"id":"GO:0030199","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0045359","count":5}]},{"hash":"1455736766454404479","title":"B cell receptor signaling with Rho GTPase regulation","description":"The cluster\u2019s top GO terms center on B cell receptor signaling and B cell differentiation, with accompanying innate immune signals and T cell differentiation terms, plus multiple GTPase- and Rho-related signaling and cytoskeletal processes (filopodium assembly). This combination suggests a cohesive theme of immune signaling modulated by Rho-family GTPases, hence the label.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050853","count":6},{"id":"GO:0060378","count":5},{"id":"GO:0051489","count":5},{"id":"GO:0002316","count":5},{"id":"GO:0001865","count":5}]},{"hash":"1755996118259211286","title":"Spliceosome Assembly and Translation Initiation","description":"The top GO terms cluster around spliceosome-mediated mRNA processing (splicing, splice site recognition, processome assembly, and regulation of splicing) and components involved in assembling translation initiation machinery (preinitiation complex formation and initiation factor 4F complex assembly). This suggests the proteins participate in nuclear RNA processing and coordination with translation initiation.","confidence":"High","size":27,"edges":334,"triangles":2636,"max_degree":26,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0034462","count":3},{"id":"GO:0006376","count":3},{"id":"GO:0097010","count":3},{"id":"GO:0006378","count":3}]},{"hash":"18828142698702577","title":"Systemic stress-response signaling","description":"The cluster\u2019s GO terms point to diverse stimulus- and signal-transduction processes: responses to temperature, xenobiotics, and diet-induced thermogenesis; pain perception and fear behavior; calcium release and ERK signaling; platelet activation and vasoconstriction; and even retina development. This pattern suggests a broad, multi-system signaling hub linked to responding to various stresses, rather than a single, cohesive function. Therefore, a high-level label like \u201cSystemic stress-response signaling\u201d is a concise, representative name, though some terms (e.g., retina development) are less tightly connected. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030168","count":13},{"id":"GO:0002024","count":13},{"id":"GO:0019233","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0045907","count":12}]},{"hash":"813580671184950798","title":"Placental development and transcriptional regulation with immune remodeling","description":"This cluster shows strong signals for transcriptional regulation by RNA polymerase II (both positive and negative regulation), suggesting coordinated control of gene expression during development. It also includes terms tied to placental-related differentiation (trophoblast giant cells, placenta development, EMT in heart/placental contexts) and collagen remodeling, with immune/vascular links (complement pathways, blood coagulation). The mix points to a broader developmental program that encompasses placental/embryonic differentiation and associated immune and extracellular matrix remodeling, rather than a single narrow function.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0003323","count":7},{"id":"GO:0001867","count":6},{"id":"GO:0045944","count":6},{"id":"GO:0007596","count":5}]},{"hash":"849793213958874526","title":"Membrane remodeling and actin-cytoskeleton signaling","description":"The cluster centers on membrane invagination, plasma membrane tubulation, and actin cortical patch assembly, pointing to cytoskeletal remodeling at the cell membrane. It also captures signaling pathways tied to Rho, PI3K, integrin, and MAPK (JUN) that regulate these structural changes, with additional immune-related terms (innate immunity, NK T cell differentiation) suggesting membrane-associated signaling in immune contexts. Overall, it reflects a cohesive theme of membrane remodeling linked to cytoskeletal dynamics and signaling, sometimes in immune-related processes.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010324","count":9},{"id":"GO:0097320","count":9},{"id":"GO:0000147","count":9},{"id":"GO:0090263","count":8},{"id":"GO:0007229","count":8}]},{"hash":"1274661151913330123","title":"Transmembrane Small-Molecule Transporters","description":"The top GO terms point to transport functions across the plasma membrane for diverse small molecules (sodium, glucose, pantothenate, myo-inositol, biotin), suggesting a cluster of membrane transport proteins responsible for uptake/export of these substrates. While a few terms mention neuronal processes, the strongest signal is membrane transport, so the name reflects the dominant function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071436","count":4},{"id":"GO:0008292","count":4},{"id":"GO:0015887","count":4},{"id":"GO:0015798","count":4},{"id":"GO:0015878","count":4}]},{"hash":"1922368929820157053","title":"Dopaminergic GPCR Signaling and Reward Regulation","description":"The cluster shows strong enrichment for dopaminergic synaptic transmission, GPCR signaling pathways that activate adenylate cyclase and/or couple to cGMP, and behavioral/autonomic processes such as eating behavior and blood pressure regulation, including renin secretion modulation. Together these suggest a coherent theme around dopamine-mediated signaling and its role in reward and autonomic regulation.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":27},{"id":"GO:0022900","count":27},{"id":"GO:0045777","count":27},{"id":"GO:0007190","count":26},{"id":"GO:0035025","count":26}]},{"hash":"320625955990346489","title":"Unknown","description":"The top GO terms are highly diverse, spanning energy production (electron transport chain), metabolic regulation (diet-induced thermogenesis), signaling (positive regulation of GTPase activity and calcium signaling), immune defense, sensory development, temperature response, and platelet activation. There isn\u2019t a single cohesive biological process tying these proteins together, so a precise functional label isn\u2019t clearly justifiable.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0060041","count":15},{"id":"GO:0008283","count":15}]},{"hash":"358485343392479933","title":"Feeding, thermogenesis, and dopaminergic signaling","description":"The terms cluster around eating behavior, saliva secretion, and heat generation, all connected to temperature-related responses, with dopaminergic synaptic transmission and GPCR-cGMP signaling, implying a coordinated feeding-reward and thermoregulatory program.","confidence":"High","size":27,"edges":139,"triangles":116,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":22},{"id":"GO:0002024","count":22},{"id":"GO:0019233","count":22},{"id":"GO:0071502","count":22},{"id":"GO:0046960","count":19}]},{"hash":"479959578841725910","title":"Eye development and transcriptional regulation","description":"This cluster is dominated by GO terms for retina and camera-type eye development, embryonic eye morphogenesis, and transcription by RNA polymerase II (including its negative regulation), pointing to a cohesive role in eye organogenesis and the transcriptional networks that drive it. While a few terms touch on broader morphogenesis, the strongest signal is eye development coupled with transcriptional control.","confidence":"High","size":27,"edges":331,"triangles":2462,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0060041","count":12},{"id":"GO:0048048","count":11},{"id":"GO:0043010","count":11},{"id":"GO:0021986","count":10}]},{"hash":"1123835996554703020","title":"Neuronal taste perception and ion signaling","description":"This cluster is dominated by GO terms for ion transmembrane transport (sodium, potassium), excitatory postsynaptic potentials, and both GABA and glutamate receptor\u2013related signaling, plus sensory taste perception (sweet) and conditioned taste aversion, along with locomotory behavior. Taken together, these terms point to proteins involved in neuronal signaling tied to taste sensation and synaptic ion transport, rather than generic metabolic functions. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":26},{"id":"GO:0007626","count":26},{"id":"GO:0001661","count":26},{"id":"GO:0071805","count":26},{"id":"GO:0060079","count":26}]},{"hash":"244222865811135336","title":"Embryonic Development and Transcription Regulation","description":"The top GO terms repeatedly point to embryonic development and organogenesis (pancreatic development, endocardial cushion EMT, cartilage morphogenesis, left-right patterning, endocrine system development) with a clear thread of transcriptional control (DNA-templated transcription, negative regulation of transcription). This suggests the cluster comprises proteins that regulate transcription during embryogenesis and tissue differentiation.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0003323","count":12},{"id":"GO:0003198","count":10},{"id":"GO:0060707","count":9},{"id":"GO:0060806","count":9}]},{"hash":"1367745132631443105","title":"NF-kappaB-driven innate immune signaling","description":"The cluster is best characterized by strong enrichment of terms centered on NF-kappaB activation and signaling (positive regulation of canonical NF-kappaB signal transduction, NF-kappaB transcription factor activity), along with innate immune responses (innate immune response, TLR/MyD88 signaling, response to LPS, IL-1\u2013mediated signaling). While there are a couple of terms related to heart development and muscle contraction, the dominant theme across the proteins is inflammatory and innate immune signaling mediated by NF-kappaB and TLR pathways.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0045087","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0002755","count":3}]},{"hash":"2127311106866458087","title":"Calcium signaling and sensory transduction","description":"The terms center on calcium release into the cytosol and its regulation, along with sensory and signaling responses (temperature, pain, phototransduction) and GPCR/prostaglandin pathways, suggesting a cluster of proteins modulating calcium-dependent signaling in sensory contexts.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":14},{"id":"GO:0002024","count":14},{"id":"GO:0051281","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0071502","count":14}]},{"hash":"1378479278415914149","title":"Neuronal projection development and axon guidance","description":"GO terms cluster around neural development, especially neuron projection development and axonal fasciculation, with signals related to trigeminal nerve structure. A few terms about heart/uterus development appear but are less representative of the dominant neural theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0060065","count":4}]},{"hash":"1028395114745887036","title":"Mitochondrial apoptosis in placental development","description":"These proteins show strong enrichment for mitochondrial outer membrane permeabilization and placental/maternal development terms, implying a role for mitochondrial-regulated apoptosis within developing tissues such as the placenta. The accompanying cell cycle and microtubule-related GO terms suggest involvement in proliferative developmental contexts (e.g., forebrain) where apoptosis and division are coordinated. ","confidence":"Medium","size":26,"edges":28,"triangles":13,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097345","count":13},{"id":"GO:0001893","count":13},{"id":"GO:0060137","count":13},{"id":"GO:1903547","count":13},{"id":"GO:0006351","count":5}]},{"hash":"1694380343573771199","title":"Lipid and small-molecule metabolism with xenobiotic response","description":"This cluster is dominated by GO terms for fatty acid biosynthesis, retinol and fructose metabolism, and ethanol oxidation/catabolism, indicating lipid and small-molecule metabolic activity. The presence of terms related to detox and stress responses (response to lipopolysaccharide, response to antineoplastic agent) suggests associated xenobiotic or immune-related regulation, but the core signal remains metabolic processing of lipids, carbohydrates, and alcohols.","confidence":"Medium","size":26,"edges":322,"triangles":2530,"max_degree":25,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006633","count":19},{"id":"GO:0042572","count":16},{"id":"GO:0046370","count":15},{"id":"GO:0006069","count":15},{"id":"GO:0006068","count":15}]},{"hash":"1164377564555506001","title":"Sex differentiation and steroid hormone metabolism","description":"The cluster shows a strong alignment of GO terms for sex differentiation, female genitalia development, and maternal parturition, together with steroid-related processes such as androgen metabolic process, cholesterol catabolic process, and vitamin D-related responses. This pattern suggests a cohesive role in reproductive development and hormone biosynthesis/metabolism. Some metal ion and environmental response terms (cesium, copper, nematode) may reflect broader stress signaling but do not define the core function.","confidence":"High","size":26,"edges":31,"triangles":7,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060137","count":26},{"id":"GO:0010164","count":26},{"id":"GO:0030540","count":26},{"id":"GO:0042369","count":26},{"id":"GO:0008209","count":26}]},{"hash":"1588706632538793703","title":"Cerebellar development and Bergmann glia differentiation","description":"This cluster is dominated by GO terms tied to cerebellar development\u2014cerebellar cortex formation and Bergmann glial cell differentiation\u2014suggesting a coherent theme around cerebellar neural development and glial differentiation, with supporting signaling pathways as secondary associations.","confidence":"High","size":26,"edges":73,"triangles":6,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021697","count":11},{"id":"GO:2001275","count":11},{"id":"GO:0008285","count":11},{"id":"GO:0060020","count":11},{"id":"GO:0050852","count":11}]},{"hash":"2280130490430806385","title":"Embryogenesis and Organogenesis","description":"This cluster is dominated by GO terms tied to embryonic development and organ formation, including trophoblast differentiation, epithelial-to-mesenchymal transition in heart formation, placenta development, endocrine system and pancreas development, cartilage morphogenesis, and left-right patterning. While there are some generic cellular-process terms present, the strongest signal centers on coordinated developmental programs shaping organs. Therefore, the label reflects the core function of the cluster. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":15},{"id":"GO:0003198","count":15},{"id":"GO:0060806","count":15},{"id":"GO:0035270","count":15},{"id":"GO:0003323","count":15}]},{"hash":"1826201798710314974","title":"Endocrine and metabolic tissue development","description":"These proteins cluster around development and function of endocrine/metabolic tissues (mammary gland alveolus development, Leydig cell differentiation, adipose tissue development) and related signaling (leptin response, bile acid biosynthesis), plus transcriptional regulation and stress response. The shared focus on tissue development within endocrine/metabolic systems, coordinated by hormonal signaling, provides a cohesive, interpretable theme for the group, with some overlap into immune signaling (Th17 differentiation). ","confidence":"Medium","size":26,"edges":100,"triangles":128,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":19},{"id":"GO:0006351","count":16},{"id":"GO:0060749","count":15},{"id":"GO:1902894","count":15},{"id":"GO:0033327","count":15}]},{"hash":"1658345080751055150","title":"RNA processing and translation with vesicle trafficking","description":"This cluster centers on translation (GO:0006412) and RNA processing steps such as mRNA capping (GO:0006370) and RNA guanine-N7 methylation (GO:0036265), alongside ER-to-Golgi vesicle transport (GO:0006888) and regulation of translational fidelity (GO:0006450). These themes point to a cohesive program of gene expression control and protein maturation/trafficking. Less central terms related to aging, apoptosis, and development likely reflect broader cellular contexts or secondary roles. ","confidence":"Medium","size":26,"edges":174,"triangles":543,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0006450","count":3},{"id":"GO:0006370","count":2},{"id":"GO:0007568","count":2}]},{"hash":"121671007350233808","title":"Retina signaling and cytoskeletal remodeling","description":"The cluster is anchored by retina- and visual perception-related terms (retina development in camera-type eye, visual perception), suggesting a retina-specific module. It also contains signaling and trafficking processes (ERK cascade regulation, GTPase activity, peptidyl-serine phosphorylation, clathrin-dependent endocytosis) along with cytoskeletal dynamics (stress fiber assembly) and ubiquitination, pointing to coordinated signaling, cytoskeletal remodeling, and membrane trafficking relevant to retinal cells. This combination supports a cohesive retina-associated signaling and structural remodeling function.","confidence":"High","size":26,"edges":50,"triangles":0,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016567","count":12},{"id":"GO:0070374","count":11},{"id":"GO:0033138","count":11},{"id":"GO:0050975","count":11},{"id":"GO:0043149","count":11}]},{"hash":"1223043181602775145","title":"Unknown","description":"The GO terms are diverse (antibiotic biosynthesis, detoxification, redox, lipid and nucleotide catabolism, and signaling regulation) with no single unifying function for the 26 proteins. The absence of a cohesive theme and the lack of edges suggest this cluster cannot be assigned a clear functional label.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0098869","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0043547","count":4}]},{"hash":"2048682872193980406","title":"Developmental signaling and differentiation regulators","description":"This cluster centers on multiple developmental signaling pathways (Wnt, Hippo, JNK, TGF-beta) and processes governing cell fate, growth, apoptosis, and tissue differentiation, including keratinocyte differentiation and placental vascular development. The proteins likely function as modulators of signaling cross-talk during development and tissue morphogenesis, hence the theme.","confidence":"High","size":26,"edges":9,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090263","count":16},{"id":"GO:0030216","count":16},{"id":"GO:0060044","count":16},{"id":"GO:0006915","count":16},{"id":"GO:0035329","count":16}]},{"hash":"2253104592143003145","title":"Unknown","description":"The top terms are heterogeneous, with a mix of neuronal differentiation and various ion/membrane-related processes, plus several obsolete annotations, and there are no edges or a cohesive functional theme connecting the proteins; a confident, representative label cannot be assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0021702","count":5},{"id":"GO:0051208","count":4},{"id":"GO:1901205","count":4},{"id":"GO:0097623","count":4},{"id":"GO:0033574","count":4}]},{"hash":"606649548181366977","title":"Neuronal development and signaling network","description":"The GO terms show nervous system development, axon/dendrite morphogenesis, and growth-related signaling (ERK, Wnt, ephrin, calcium exocytosis), suggesting a cohesive cluster of proteins coordinating neural development and synaptic signaling. Some terms touch on broader signaling pathways, but the dominant neural themes support this label.","confidence":"High","size":26,"edges":15,"triangles":4,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":20},{"id":"GO:0007399","count":20},{"id":"GO:0050852","count":19},{"id":"GO:0045773","count":19},{"id":"GO:0048813","count":18}]},{"hash":"28428714211545452","title":"Neural Pain Perception and Drug-Reward Signaling","description":"The cluster is dominated by terms for sensory pain perception, dopaminergic synaptic transmission, GPCR-cGMP signaling, and behavioral responses to morphine and cocaine, indicating proteins involved in neural sensory processing and reward pathways. Additional terms related to temperature responses, prostaglandin signaling, and membrane potential regulation support a broader neuronal signaling context tied to perception and drug-induced behaviors.","confidence":"High","size":26,"edges":48,"triangles":6,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":21},{"id":"GO:0002024","count":20},{"id":"GO:0071502","count":20},{"id":"GO:0007601","count":17},{"id":"GO:0007199","count":16}]},{"hash":"1473274050266930777","title":"Neuronal Synaptic Transmission and Plasticity","description":"This cluster is dominated by terms tied to neuronal communication and plasticity: long-term potentiation, neurotransmitter secretion, regulation of synaptic vesicle exocytosis, and calcium- and phosphatidylinositol-mediated signaling, all central to synaptic signaling in neurons. Some accompanying terms related to hypoxia and apoptosis may reflect neuronal stress responses, but the core theme is synaptic transmission and plasticity.","confidence":"High","size":26,"edges":168,"triangles":533,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060291","count":21},{"id":"GO:0071277","count":20},{"id":"GO:0048015","count":20},{"id":"GO:0043065","count":20},{"id":"GO:0007269","count":20}]},{"hash":"1735730587173425421","title":"Nuclear transcription and DNA replication regulation","description":"The dominant GO terms revolve around RNA polymerase II transcription regulation, preinitiation complex assembly, DNA replication, and cell cycle transitions (G1/S), with related chromatin modification and RNA-templated DNA processes. This suggests a nuclear program coordinating transcription control with DNA synthesis and replication, justifying a label like this. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0070940","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0043966","count":3}]},{"hash":"2074241703539216226","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032543","count":8},{"id":"GO:0019876","count":8},{"id":"GO:0009062","count":8},{"id":"GO:0070681","count":8},{"id":"GO:0007029","count":8}]},{"hash":"1305140950680199454","title":"Organogenesis and Hormonal Signaling","description":"This cluster centers on organ development terms (heart, liver, multicellular organism development) together with signaling pathways (calcineurin-NFAT, growth hormone receptor signaling, thyroid hormone response) and tissue interactions (cell-matrix adhesion, axon guidance), suggesting a group involved in morphogenesis and hormonal regulation of tissue differentiation rather than a single pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0007507","count":7},{"id":"GO:0001889","count":6},{"id":"GO:0070886","count":6},{"id":"GO:0060396","count":6}]},{"hash":"1422045090668857603","title":"Steroid and pigment metabolite biosynthesis","description":"GO terms indicate biosynthesis and metabolism of steroids (androgen, testosterone), lipids (3-keto-sphinganine), vitamins/cofactors (phylloquinone, tetrahydrobiopterin), and pigments (melanin, retinal). The cluster thus reflects broad metabolite biosynthesis across diverse small molecules rather than a single pathway, with a developmental term (lung) as a milder association. Confidence: Medium","confidence":"","size":26,"edges":287,"triangles":1846,"max_degree":25,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":26},{"id":"GO:0006666","count":26},{"id":"GO:0042376","count":26},{"id":"GO:0061370","count":26},{"id":"GO:0017000","count":26}]},{"hash":"1704672883620377519","title":"Synaptic vesicle trafficking and Rho-GTPase signaling","description":"The terms converge on synapse formation and function (synapse assembly, long-term potentiation), vesicle dynamics (vesicle exocytosis, vesicle fusion, endocytosis regulation), and cytoskeletal remodeling via Rho GTPases and actin crosslinking, all pointing to a coordinated module of synaptic signaling and vesicle trafficking. A minor item is a T cell anergy term that may be less directly related.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007416","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0043087","count":4},{"id":"GO:0048015","count":4}]},{"hash":"1097668998030346739","title":"RNA processing and developmental regulation","description":"The dominant GO terms center on RNA processing and gene expression control (translation, spliceosome-mediated splicing, transcription by RNA Pol II) and are complemented by terms about development and eye morphogenesis (heterochronic regulation, eye morphogenesis, stem cell maintenance). This combination suggests a cluster of proteins linked to coordinated regulation of gene expression during development. Some terms like UV response and insulin secretion indicate additional context-specific roles or secondary functions.","confidence":"Medium","size":26,"edges":18,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0071157","count":3},{"id":"GO:1902455","count":2},{"id":"GO:1901666","count":2}]},{"hash":"1755661440933805056","title":"Neural development and synapse formation","description":"The top terms are dominated by nervous system development, axonal fasciculation, and positive regulation of synapse assembly, plus ERK signaling regulation, pointing to roles in neuronal development and synaptic formation. Additional terms about innate immunity and bone maturation appear as broader pathway associations but do not define the cluster's main theme. Overall, the shared function appears to be neuronal development and synaptic regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0051092","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0007275","count":7}]},{"hash":"668059121028298425","title":"Ubiquitin-Dependent Proteolysis in Neurons and Circadian Regulation","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent proteolysis, polyubiquitination, SCF-dependent degradation, ERAD) with additional links to neuron-specific functions (synapse assembly, neuronal apoptotic signaling) and circadian rhythm regulation, suggesting a cohesive theme around ubiquitin-driven protein turnover in neuronal contexts and its relation to circadian control.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":22},{"id":"GO:0000209","count":11},{"id":"GO:1903265","count":11},{"id":"GO:0030433","count":11},{"id":"GO:0031146","count":11}]},{"hash":"951443698553066524","title":"Spliceosome-driven mRNA processing and translation initiation","description":"The top GO terms are dominated by mRNA splicing via the spliceosome, spliceosome assembly and splice site recognition, plus formation of the translation preinitiation complex and translation initiation factor 4F complex assembly. This points to a cohesive theme of RNA processing and initiation of translation as the cluster\u2019s primary function. While signaling terms like Rho and TGF-beta pathways appear, they seem secondary to the RNA-processing/translation focus. Confidence: High","confidence":"","size":26,"edges":34,"triangles":2,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007179","count":4},{"id":"GO:0045292","count":3},{"id":"GO:0034462","count":3},{"id":"GO:0006376","count":3}]},{"hash":"981674432120528863","title":"DNA replication, repair, and recombination proteins","description":"This cluster centers on DNA metabolism, with strong representation of DNA repair, replication, recombination, and related processes (e.g., DNA templated replication, DNA recombination, DNA integration). A translation term appears less connected and likely incidental, but the dominant GO terms point to a cohesive theme of DNA maintenance and genome dynamics.","confidence":"High","size":26,"edges":5,"triangles":0,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0006310","count":5},{"id":"GO:0071897","count":4},{"id":"GO:0006261","count":4}]},{"hash":"483784200469804998","title":"Ubiquitin-Dependent ERAD and Innate Immunity","description":"This cluster is strongly enriched for ubiquitin-dependent ERAD and protein catabolic processes, coupled with defense against viruses and innate immune responses, indicating a cohesive role of ubiquitin-proteasome\u2013driven degradation in immune signaling. Some terms related to development and skin may reflect tissue-specific expression rather than core function, but the dominant theme ties proteostasis to innate immunity.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":19},{"id":"GO:0042787","count":18},{"id":"GO:0051607","count":16},{"id":"GO:0045087","count":16},{"id":"GO:0051865","count":16}]},{"hash":"1112008059566598784","title":"Mitotic Chromatin Regulation","description":"The cluster is enriched for mitosis-related terms (mitotic cell cycle, mitotic spindle assembly) along with DNA-templated transcription and histone methylation (H3-K27/K4/K79), suggesting a cohesive role in coordinating chromatin state with cell division and transcription during mitosis. Some terms are obsolete, but the core theme of chromatin regulation during mitosis remains strong.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0061087","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1361739271700957027","title":"Synaptic Transmission and Ion Transport","description":"Dominant GO terms center on sodium/potassium ion transmembrane transport, excitatory postsynaptic potentials, and GABA/glutamatergic signaling, indicating a cluster of proteins involved in neuronal communication and synaptic modulation. Behavioral terms such as locomotory behavior and conditioned taste aversion further support a neural-circuit function; a few catabolic and viral-release terms appear ancillary and less central to the core theme.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":25},{"id":"GO:0071805","count":25},{"id":"GO:0060079","count":25},{"id":"GO:0007626","count":25},{"id":"GO:0001661","count":25}]},{"hash":"581008464394445846","title":"Thermogenesis and Energy Signaling","description":"This cluster is dominated by terms related to temperature- and diet-induced thermogenesis, cellular response to temperature, and GPCR-cAMP signaling, plus electron transport chain activity, pointing to genes involved in energy metabolism and thermogenic regulation. The presence of pain perception and visual learning hints at neural involvement, while inflammatory response and membrane potential regulation suggest neural-vascular-immune coupling. Together, these terms imply a cohesive theme around energy homeostasis and thermogenic signaling with neural and cardiovascular aspects rather than a single isolated pathway.","confidence":"Medium","size":26,"edges":12,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":13},{"id":"GO:0019233","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0007190","count":13}]},{"hash":"470171808297258971","title":"Sweet Taste Perception and Neural Signaling","description":"The top GO terms converge on gustatory sensing (sweet taste) and neural communication: sweet taste detection, GPCR signaling, regulation of sensory perception and glutamatergic synaptic transmission, plus conditioned taste aversion and locomotory behavior\u2014hallmarks of neural circuits governing taste, learning, and movement. A few terms like defense response to bacterium and peptidoglycan catabolic processes appear as outliers but do not override the central theme. Overall, the cluster seems to represent gustatory sensation and associated neural signaling in behavior.","confidence":"High","size":26,"edges":42,"triangles":25,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001582","count":25},{"id":"GO:0007196","count":25},{"id":"GO:0051930","count":25},{"id":"GO:0007626","count":25},{"id":"GO:0042742","count":25}]},{"hash":"1184222442041743217","title":"Developmental signaling and cytoskeletal regulation","description":"This cluster centers on developmental processes and cytoskeletal control, with proteins annotated for multicellular organism development and spinal cord development, combined with regulation of actin nucleation (Arp2/3) and microtubule-based movement. Ubiquitin-dependent pathways and polyubiquitination also appear, suggesting turnover and quality control roles that couple signaling with protein degradation. Together with GO terms for GTPase activity regulation and hypoxia response, the group likely represents proteins coordinating development with cytoskeletal dynamics and protein turnover.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0031954","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0034316","count":4},{"id":"GO:0007018","count":4}]},{"hash":"891567301991687282","title":"Organogenesis and tissue morphogenesis","description":"The cluster\u2019s top GO terms are centered on developmental processes across multiple tissues and organs (eye-related development, cranial skeleton morphogenesis, kidney development, EMT in heart development, osteoblast differentiation, and male gonad/imaginal disc-derived structures). While there are also general cellular processes like protein transport and microtubule movement, the dominant theme is organ formation and tissue differentiation, suggesting a cohesive developmental/morphogenesis role for these proteins.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0006986","count":4},{"id":"GO:0061029","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0007018","count":3}]},{"hash":"1270029228918179044","title":"Coagulation and Inflammatory Response","description":"The top GO terms are dominated by blood coagulation, fibrinolysis, plasminogen activation, and an inflammatory/LPS response, suggesting a cluster of proteins involved in hemostasis and innate immune signaling. A few terms like brown fat differentiation or spinal cord development appear less connected, likely representing peripheral associations or pleiotropy, but the central pattern points to coagulation/fibrinolysis with inflammation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050873","count":4},{"id":"GO:0016525","count":3},{"id":"GO:0021517","count":3},{"id":"GO:0051968","count":3},{"id":"GO:0090129","count":3}]},{"hash":"640484754629564539","title":"DNA Damage Response and Cell Cycle Regulation","description":"The top GO terms point to DNA damage sensing and repair (intrinsic apoptotic signaling in response to DNA damage; nucleotide-excision repair), regulation of the cell cycle, and transcription, with supporting roles for protein modification processes (deubiquitination and deneddylation) and inflammatory signaling. This suggests a cohesive module focused on recognizing DNA damage, coordinating repair, and controlling cell cycle progression and related stress responses, rather than unrelated developmental processes. High","confidence":"","size":25,"edges":44,"triangles":25,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045471","count":7},{"id":"GO:0008630","count":6},{"id":"GO:0006297","count":6},{"id":"GO:0051726","count":5},{"id":"GO:0048536","count":5}]},{"hash":"1377214943092852361","title":"Vertebrate eye and hindbrain morphogenesis","description":"The top GO terms cluster around eye and neural development\u2014retina development, camera-type eye development, embryonic eye morphogenesis, brain segmentation, and rhombomere 5 development\u2014indicating a shared vertebrate eye\u2013brain organogenesis program. Additional terms on lung morphogenesis, vascular wound healing, and osteoblast development reflect broader embryonic morphogenesis but do not override the central theme. ","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0060041","count":12},{"id":"GO:0035284","count":10},{"id":"GO:0021571","count":10},{"id":"GO:0060441","count":9}]},{"hash":"217338992318847174","title":"Protein Tyrosine Phosphatases in Signaling Regulation","description":"The cluster is dominated by GO terms for peptidyl-tyrosine dephosphorylation and negative regulation of signaling pathways (ERK/MAPK cascade, T cell receptor signaling), along with PI and inositol phosphate dephosphorylation, plus neuronal development and myelination. This points to a cohesive role for protein tyrosine phosphatases dampening signaling across immune and neural contexts, with implications for neural development and cellular homeostasis.","confidence":"High","size":25,"edges":238,"triangles":1249,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0035335","count":16},{"id":"GO:0000200","count":12},{"id":"GO:0070373","count":12},{"id":"GO:0050860","count":12},{"id":"GO:0032435","count":9}]},{"hash":"376770217582941466","title":"Neural Development and Cell Cycle","description":"The cluster combines neural development terms (nervous system development, hippocampus development, dendrite morphogenesis) with core cell cycle and DNA maintenance processes (mitotic cell cycle, DNA replication, DNA repair, DNA-templated transcription, protein stability). This pattern suggests proteins involved in neural development that are active during cell proliferation and genome maintenance, likely neural progenitors; the one outlier term (beta selection) may reflect cross-domain annotation but does not outweigh the main theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":22},{"id":"GO:0006260","count":21},{"id":"GO:0006281","count":21},{"id":"GO:0006351","count":21},{"id":"GO:0048813","count":21}]},{"hash":"2219364674367754309","title":"Auditory system development and glutamatergic synapses","description":"This cluster centers on nervous system development, inner ear development, and sensory perception of sound, with emphasis on glutamatergic synaptic transmission and regulation of synapse assembly. The combination of terms like DNA-templated transcription and synaptic signaling supports a cohesive theme of neural development and auditory synapse function, while stress-response terms appear as ancillary signals.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0051965","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007605","count":5},{"id":"GO:0071276","count":5}]},{"hash":"2240411504495367324","title":"Transmembrane Transport of Ions and Xenobiotics","description":"These proteins are strongly linked to membrane transport across various substrates, especially xenobiotics, vitamins, sugars, and ions. The top GO terms (vitamin transmembrane transport, xenobiotic transmembrane transport, sodium/potassium ion transport, and related sugar transport) point to a cohesive set of transporter proteins with broad substrate specificity; a single term about replicative senescence appears incidental.","confidence":"High","size":25,"edges":260,"triangles":1531,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":25},{"id":"GO:0006855","count":25},{"id":"GO:0071805","count":23},{"id":"GO:0042908","count":23},{"id":"GO:0042891","count":20}]},{"hash":"2300487290997230740","title":"Cilium-Driven Photoreceptor Signaling","description":"Dominant terms are cilium assembly and visual perception, with links to vesicle trafficking, presynaptic assembly, and growth-regulatory signaling, pointing to a theme of cilium-associated signaling in photoreceptors or other ciliated neurons; other terms may reflect general cellular processes that co-occur but do not define the cluster.","confidence":"Medium","size":25,"edges":212,"triangles":1042,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":21},{"id":"GO:0007601","count":21},{"id":"GO:0043547","count":19},{"id":"GO:0033160","count":13},{"id":"GO:0035330","count":13}]},{"hash":"1829080160965658540","title":"Developmental transcriptional regulation","description":"The GO terms center on developmental processes (heart and cerebellar cortex development) and transcriptional control (DNA-templated transcription, transcription initiation at RNA Pol II promoter), with supporting signals from cell cycle and growth pathways (mitotic cell cycle, insulin receptor signaling). Cadmium response and proteasomal regulation suggest stress- and proteostasis-linked modulation of transcription, reinforcing a theme of regulation of gene expression during development. Overall, the dominant function appears to be developmental transcriptional regulation with growth signaling involvement.","confidence":"Medium","size":25,"edges":18,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0071276","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0008286","count":4}]},{"hash":"1932801325158260003","title":"RNA processing and translational regulation","description":"The cluster\u2019s top GO terms emphasize post-transcriptional RNA handling and control of protein synthesis, including mRNA splicing via the spliceosome, regulation of translational initiation (including IRES-dependent initiation), translation reinitiation, and mRNA stability in stress. This points to a cohesive theme of RNA processing coupled with regulation of translation, covering both splicing-related and translational control activities.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0045292","count":6},{"id":"GO:0006378","count":6},{"id":"GO:0048026","count":6}]},{"hash":"1321836380972164513","title":"RNA splicing, processing, and translation initiation","description":"The cluster\u2019s top GO terms cluster around spliceosome-mediated mRNA processing (positive/negative regulation of splicing, cis splicing), mRNA export, and translation initiation/reinitiation, with rRNA maturation also tied to RNA metabolism. While DNA replication and repair appear, the dominant theme is RNA processing and control of translation, suggesting a nucleus-centric RNA metabolism hub.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0006406","count":6},{"id":"GO:0045292","count":5}]},{"hash":"533722205492771183","title":"Rho GTPase signaling and actin cytoskeleton remodeling","description":"This cluster centers on Rho GTPase\u2013mediated control of the actin cytoskeleton, with recurrent terms for positive regulation of GTPase activity, Rho signaling, podosome and actin cortical patch assembly/localization, and phosphorylation events that modulate these processes\u2014together pointing to coordinated cytoskeletal dynamics.","confidence":"High","size":25,"edges":24,"triangles":0,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0016310","count":6},{"id":"GO:0035023","count":6},{"id":"GO:1990314","count":6},{"id":"GO:0071800","count":6}]},{"hash":"873217132375609695","title":"Immune receptor signaling and cytoskeletal regulation","description":"The top GO terms point to robust signaling through T cell receptor and related pathways (ERK cascade, MAPKK, PI3K), plus ephrin and Wnt signaling, and concurrent cytoskeletal dynamics (actin reorganization, focal adhesion). This suggests a cohesive theme of immune receptor\u2013driven signaling coupled to cytoskeletal remodeling and cell movement.","confidence":"High","size":25,"edges":41,"triangles":24,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":25},{"id":"GO:0050852","count":25},{"id":"GO:0033138","count":25},{"id":"GO:0090263","count":25},{"id":"GO:0048013","count":25}]},{"hash":"1752825682813721768","title":"Embryonic development and organogenesis","description":"The prominent GO terms describe core developmental processes across multiple organs (eye, brain, neural crest, pancreas, urinary tract, digestive tract) and pattern specification, suggesting the proteins participate in broad embryonic development and organ formation rather than a single tissue. This label captures the shared theme of developmental regulation and morphogenesis. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0001755","count":8},{"id":"GO:0043010","count":8},{"id":"GO:0030901","count":7},{"id":"GO:0031018","count":7}]},{"hash":"1935076789930997110","title":"Mitotic regulation and kinase signaling proteins","description":"This cluster is dominated by mitosis- and signaling-related GO terms (mitotic cell cycle, mitotic spindle assembly, and positive regulation of protein serine/threonine kinase activity, plus regulation of GTPase activity and autophosphorylation), pointing to cell-cycle control and kinase-driven signaling as the core theme. Some terms like skin development and defense response may reflect pleiotropy or broader regulatory roles, but the central pattern supports a mitotic/kinase signaling function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070208","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0043588","count":8},{"id":"GO:0071456","count":7},{"id":"GO:0043547","count":7}]},{"hash":"406924853800605594","title":"Steroid, pigment, vitamin, and antibiotic biosynthesis","description":"The cluster is enriched for a range of biosynthetic pathways, including steroid biosynthesis (androgen and glucocorticoid), pigment-related routes (retinal and melanin), vitamin-related metabolism (phylloquinone), and secondary metabolite biosynthesis (tropane alkaloids, antibiotics) as well as PHB biosynthesis. This suggests a common theme of diverse metabolite production rather than a single specific function, indicating a broad biosynthetic/metabolic cluster.","confidence":"Medium","size":25,"edges":24,"triangles":22,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":13},{"id":"GO:0042376","count":12},{"id":"GO:0017000","count":12},{"id":"GO:0055114","count":12},{"id":"GO:0030324","count":12}]},{"hash":"1477664199058078520","title":"Embryonic morphogenesis and neural development","description":"The terms cluster around eye/retina development (retina morphogenesis, visual perception) and forebrain proliferation, tied together by signaling processes (Rho, GTPase regulation) that govern morphogenesis and cytoskeletal dynamics. While there are additional morphogenesis terms (ossification, genitalia development), the overarching theme appears to be embryonic tissue morphogenesis with a neural development emphasis.","confidence":"Medium","size":25,"edges":7,"triangles":0,"max_degree":2,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0001957","count":3},{"id":"GO:0060059","count":3},{"id":"GO:0050872","count":3}]},{"hash":"1670394129881388498","title":"DNA Repair and Ribosome Biogenesis","description":"The proteins cluster around nucleic acid maintenance (nucleotide-excision repair, DNA recombination, SOS response) and ribosome biogenesis/export, with some cell division terms, suggesting a coordinated theme of genome stability alongside ribosome assembly during growth. Peripheral terms related to stress responses appear secondary to this core connectivity.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006289","count":3},{"id":"GO:0090305","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0042254","count":3}]},{"hash":"1025221519321165036","title":"Multisystem Development and Remodeling","description":"The top GO terms point to developmental differentiation across multiple tissues (pancreas, midbrain, lens, trophoblast) and associated remodeling processes (endothelial barrier establishment, tissue remodeling, fibrinolysis), plus regulatory control of transcription. This suggests a cluster of proteins involved in broad developmental programs and tissue remodeling rather than a single tissue-specific function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0003323","count":7},{"id":"GO:0030901","count":6},{"id":"GO:1903142","count":5},{"id":"GO:0070306","count":5}]},{"hash":"1700148593969155925","title":"Innate Immune Signaling and Leukocyte Migration","description":"This cluster is dominated by GO terms related to innate immune response and cell movement, including lamellipodium assembly, adhesion-dependent cell spreading, and B cell proliferation. The enrichment of signals that promote immune activation and cytoskeletal remodeling points to functions in immune cell signaling and motility. A few terms (thymus development, Wnt signaling, and synaptic potentiation) are less central but may reflect broader signaling cross-talk in the dataset.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0090263","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0048538","count":3}]},{"hash":"1051920554368580685","title":"Embryonic Development and Morphogenesis","description":"The terms cluster around broad developmental processes across multiple tissues, including placental differentiation, EMT in heart cushion formation, endocrine system development, cartilage and hair follicle morphogenesis, palate formation, and left-right patterning. This suggests proteins involved in general embryogenesis and tissue morphogenesis rather than a single specific pathway.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":21},{"id":"GO:0003198","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0035270","count":21},{"id":"GO:0003323","count":21}]},{"hash":"1538585880606302552","title":"Neural and Cardiac Development with Autophagy","description":"The GO terms are dominated by neural and heart development (brain development, neuron development, heart development) with supporting signals (positive regulation of GTPase activity) and cellular remodeling (autophagy). While there are also metabolic terms (glucose transport, adipose development) and brood size regulation, the strongest pattern points to developmental programs in neural and cardiac tissues, often linked with signaling and cell cycle activity.","confidence":"Medium","size":25,"edges":19,"triangles":0,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0000278","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0043065","count":3}]},{"hash":"2039332026691804710","title":"B cell signaling and complement-mediated phagocytosis","description":"The GO terms cluster around B cell receptor signaling, classical complement activation, and phagocytosis (recognition and engulfment), with associated adhesion and receptor-mediated endocytosis, pointing to adaptive immune activation and antigen uptake; a lone triglyceride catabolic term appears incidental noise.","confidence":"High","size":25,"edges":29,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0050871","count":6}]},{"hash":"2302110533068257909","title":"Stress-Related mRNA Stability and Decay","description":"This cluster is dominated by GO terms centered on post-transcriptional mRNA regulation: stress-induced regulation of mRNA stability, mRNA catabolic processes, exonucleolytic RNA hydrolysis, and mitochondrial mRNA polyadenylation. The strongest signals point to mRNA turnover and processing under stress, including miRNA-mediated decay and mRNA binding regulation. Some terms (e.g., neuronal action potential regulation, viral RNA transport) appear as outliers but do not override the core RNA metabolism theme. Confidence: High","confidence":"","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":23},{"id":"GO:0090503","count":14},{"id":"GO:0006402","count":13},{"id":"GO:0098908","count":13},{"id":"GO:2000627","count":13}]},{"hash":"1924987591499812535","title":"Epithelial Polarity & Inflammatory Signaling","description":"The cluster centers on epithelial cell polarity and tight junction assembly, with concurrent signaling pathways linked to inflammation and survival (NF-kappaB activation, LPS signaling, PI3K/AKT, autophagy, and anti-apoptotic regulation), suggesting a cohesive role in epithelial barrier function paired with inflammatory responses.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:0090162","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0051092","count":2}]},{"hash":"444153118181000105","title":"Neural development and glutamate receptor signaling","description":"The top GO terms point to nervous system development (forebrain and general nervous system), and specifically ionotropic glutamate receptor signaling, together with related neural functions like visual learning and behavior. These indicate a coherent theme of brain development and glutamatergic signaling, with some obsolete terms likely representing noise. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":3},{"id":"GO:0001967","count":3},{"id":"GO:0030818","count":3},{"id":"GO:0035235","count":3},{"id":"GO:1901726","count":2}]},{"hash":"2256948417634282839","title":"Wnt/BMP signaling regulators and apoptosis","description":"These proteins show GO terms centered on regulation of Wnt signaling (both positive and negative) and BMP signaling, coupled with osteoclast differentiation and apoptotic processes. This suggests roles as regulators of signaling pathways affecting bone remodeling and cell survival, justifying a label focused on Wnt/BMP signaling and apoptosis.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0045671","count":3},{"id":"GO:0035023","count":3},{"id":"GO:2000009","count":3},{"id":"GO:0030514","count":2}]},{"hash":"36570224965566056","title":"Immune Synapse and T Cell Activation","description":"The cluster is strongly enriched for T cell\u2013related functions (costimulation, proliferation, synapse assembly) and cell adhesion, plus innate immune response and classical complement activation, which together point to immune cell communication and activation through the immune synapse. Some terms like nervous system development and ossification appear as secondary associations, but the core theme is adaptive immune signaling and T cell interactions.","confidence":"High","size":25,"edges":131,"triangles":200,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0007399","count":14},{"id":"GO:0007156","count":14},{"id":"GO:0031295","count":12},{"id":"GO:0042102","count":12}]},{"hash":"625721837113463425","title":"Inflammation-driven vascular remodeling","description":"Top GO terms emphasize inflammatory signaling (acute-phase response; IL-1\u03b2 and fractalkine production) together with vascular processes (endothelial barrier establishment, fibrinolysis, tissue remodeling, and angiogenesis). This suggests a cohesive cluster where inflammatory cues coordinate remodeling of the vasculature and extracellular matrix. While midbrain development is listed and may reflect broader developmental roles, the dominant theme across the proteins appears to be inflammation-linked vascular remodeling rather than a neural-specific function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":10},{"id":"GO:1903142","count":9},{"id":"GO:0042730","count":8},{"id":"GO:0050720","count":8}]},{"hash":"1088387826188732851","title":"Unknown","description":"The GO terms span host-symbiont entry, immune costimulation, cell adhesion regulation, proteolysis, stress responses (hypoxia and oxidant detoxification), and even chlorophyll catabolic and behavioral processes, with no clear shared function connecting the proteins. The absence of edges and the diverse terms indicate no coherent theme to label beyond Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0001662","count":3},{"id":"GO:0015996","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0036343","count":3}]},{"hash":"84553423340625033","title":"Endothelial Morphogenesis and Angiogenesis Regulation","description":"This cluster is dominated by terms tied to vascular endothelial development and control of blood vessel formation\u2014endothelial morphogenesis, negative regulation of angiogenesis, and reduced endothelial proliferation\u2014suggesting a set of proteins involved in vascular regulation. A few terms also touch immune and neuronal aspects, but the major theme remains endothelial/angiogenic control.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035990","count":2},{"id":"GO:0042985","count":2},{"id":"GO:0010977","count":2},{"id":"GO:0007585","count":2},{"id":"GO:0016525","count":2}]},{"hash":"1986804793547590265","title":"ECM remodeling and immune signaling","description":"The top GO terms cluster around extracellular matrix interactions and remodeling (blood coagulation; calcium-independent cell-matrix adhesion; integrin signaling; regulation of ECM assembly; metallopeptidase activity) and immune activation (T cell activation via TCR-MHC interactions). Additional terms related to protein turnover (ubiquitin-dependent degradation) and protein complex formation (heterotrimerization) support a theme of ECM remodeling linked to immune signaling, though a few annotations (e.g., chlorophyll biosynthesis) may be noise. Overall, the cluster seems to represent extracellular matrix remodeling coupled with immune cell signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":11},{"id":"GO:0007161","count":11},{"id":"GO:0031104","count":11},{"id":"GO:0007229","count":10},{"id":"GO:0002291","count":10}]},{"hash":"695623212917281290","title":"Embryonic development and organogenesis","description":"The top GO terms cluster around diverse developmental and differentiation processes across multiple tissues (heart-related endocardial cushion formation, pancreas development, placental differentiation, cartilage morphogenesis, and left-right patterning), indicating a cohesive theme of embryogenesis and organogenesis rather than a single tissue or molecular function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0060707","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0035270","count":6}]},{"hash":"1705760753555611842","title":"Dopaminergic GPCR signaling and autonomic regulation","description":"The dominant terms describe dopamine-related GPCR signaling (adenylate cyclase activation, cGMP-linked GPCR pathways) and dopaminergic synaptic transmission, with accompanying autonomic/metabolic outputs such as blood pressure regulation, renin secretion, eating behavior, and heat generation, suggesting a cohesive theme of dopamine-driven GPCR signaling coordinating autonomic and metabolic functions.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":25},{"id":"GO:0007190","count":25},{"id":"GO:0022900","count":25},{"id":"GO:0045777","count":25},{"id":"GO:0046960","count":21}]},{"hash":"958385027890655183","title":"Enteric neuropeptide signaling and gut motility","description":"The top GO terms cluster around the enteric nervous system, peristalsis, eating behavior, and appetite regulation, all linked by neuropeptide signaling and GPCR/ERK pathway activity. While there are also immune and xenobiotic response terms, the dominant theme centers on enteric neural control of gut motility and feeding behavior, suggesting a cohesive group of proteins involved in enteric signaling networks that regulate peristalsis and appetite.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030432","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0042493","count":16},{"id":"GO:0048484","count":16},{"id":"GO:0042755","count":16}]},{"hash":"1509445303220907697","title":"Embryonic development and tissue morphogenesis","description":"The terms point to broad embryonic development and tissue morphogenesis across multiple lineages (heart EMT, left-right patterning, placenta/endocrine development, cartilage and hair follicle morphogenesis, palate formation), indicating these proteins function in organogenesis and patterning rather than a single tissue-specific role.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":25},{"id":"GO:0003323","count":25},{"id":"GO:0060806","count":25},{"id":"GO:0060972","count":25},{"id":"GO:0060707","count":25}]},{"hash":"312296155468230120","title":"Epithelial Polarity and Junctional-Cytoskeletal Regulation","description":"The top GO terms cluster around establishing epithelial cell apical/basal polarity, tight junction and microvillus assembly, and regulation of adhesion and cytoskeletal signaling (Rho, integrin-mediated adhesion, centrosome localization). These points together to a module governing epithelial polarity, junctional integrity, and cytoskeletal organization. Some terms (e.g., equilibrioception, STAT regulation) are peripheral, but the core theme is clear.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0008285","count":6},{"id":"GO:0051835","count":6},{"id":"GO:0035023","count":5},{"id":"GO:0070830","count":5},{"id":"GO:0045198","count":5}]},{"hash":"1728327960682475548","title":"TGF-\u03b2/BMP-SMAD signaling in development","description":"The cluster is dominated by GO terms for TGF-\u03b2 receptor signaling, BMP signaling, and SMAD transduction, with supportive terms for neuronal and sensory organ development (neuron, lens fiber, antennal joint development) and transcriptional regulation. This pattern points to proteins involved in developmental signaling pathways, particularly TGF-\u03b2/BMP and their downstream SMAD-mediated transcriptional effects, rather than a single narrow function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0070306","count":4},{"id":"GO:0048666","count":4},{"id":"GO:0048147","count":4},{"id":"GO:0007179","count":4}]},{"hash":"2198783891369788841","title":"Photoreceptor maintenance and host defense","description":"The dominant term is photoreceptor cell maintenance (15), indicating a core theme around photoreceptor function or maintenance. This is supported by substantial representation of defense-related terms (defense response to bacterium, viral release from host cell, cytolysis) and ancillary metabolic/process terms (peptidoglycan catabolic process, electron transport chain). Together, the cluster seems to combine photoreceptor-associated maintenance with host-pathogen interaction and related metabolic activity, rather than a single narrow pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045494","count":15},{"id":"GO:0042742","count":13},{"id":"GO:0051482","count":13},{"id":"GO:0016998","count":13},{"id":"GO:0009253","count":13}]},{"hash":"1065143038737592517","title":"Platelet Activation and Cytoskeleton Signaling","description":"The terms show strong emphasis on thrombin-activated receptor signaling, regulation of Rho signaling, and positive regulation of platelet activation, which point to signaling pathways governing platelet function and cytoskeletal remodeling. Additional terms like lamellipodium assembly and mitochondrial fission reflect downstream cytoskeletal dynamics and broader cell signaling related to these processes, supporting a cohesive theme around platelet activation and cytoskeleton remodeling in a cardiovascular context.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0070493","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0010572","count":5},{"id":"GO:0000266","count":5},{"id":"GO:0060048","count":5}]},{"hash":"559536296165156657","title":"Mammary gland development and cell cycle regulation","description":"The cluster is enriched for terms related to cell cycle control (positive regulation of CDK activity, mitotic cell cycle, re-entry into mitosis) and mammary tissue biology (lactation, mammary gland epithelial cell proliferation), with supporting pathways such as Wnt signaling. While there are a few terms pointing to other differentiation contexts, the dominant signal ties proliferation and development to mammary gland biology, suggesting these proteins coordinate cell division with tissue-specific differentiation.","confidence":"Medium","size":24,"edges":233,"triangles":1377,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045737","count":15},{"id":"GO:0051301","count":15},{"id":"GO:0035186","count":14},{"id":"GO:0007595","count":14},{"id":"GO:0033598","count":14}]},{"hash":"1433778592128340100","title":"Transcription Regulation and Cell Cycle Control","description":"This cluster centers on transcriptional control and cell cycle progression. The top GO terms emphasize transcriptional processes (negative regulation of transcription by RNA polymerase II; DNA-templated transcription) and cell cycle events (G2/M transition, re-entry into the mitotic cycle, overall regulation of the cell cycle). Additional terms point to developmental contexts (Leydig cell differentiation, mammary gland development), implying these proteins coordinate development-linked transcription programs with proliferation.","confidence":"High","size":24,"edges":22,"triangles":3,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0006351","count":11},{"id":"GO:0033327","count":10},{"id":"GO:0060749","count":10},{"id":"GO:0033598","count":8}]},{"hash":"1233877282387702587","title":"Developmental Morphogenesis and Signaling","description":"The top GO terms point to tissue and neural development (dendrite morphogenesis, outer ear morphogenesis, mammary gland epithelial proliferation) and various signaling responses (prostaglandin E stimulus, phorbol ester response), suggesting the cluster centers on developmental processes and signaling regulation. Additional terms like regulation of leukocyte chemotaxis and sterol import, plus DNA repair and cyclic nucleotide biosynthesis, indicate broader cellular regulation, but the dominant theme appears to be development-related morphogenesis with signaling involvement.","confidence":"Medium","size":24,"edges":263,"triangles":1752,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":24},{"id":"GO:1990804","count":24},{"id":"GO:0033598","count":24},{"id":"GO:0002688","count":24},{"id":"GO:0071380","count":24}]},{"hash":"737593860680433529","title":"Motor neuron axonogenesis and migration","description":"The top GO terms are dominated by motor neuron development and axon navigation (peripheral nervous system neuron axonogenesis, motor neuron axon guidance, lateral motor column neuron migration) and supported by cell-matrix adhesion, suggesting a coherent theme of motor neuron outgrowth and neuromuscular connectivity; a few terms related to unrelated processes appear but do not define the cluster.","confidence":"Medium","size":24,"edges":230,"triangles":1198,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0048936","count":20},{"id":"GO:0007160","count":20},{"id":"GO:0008045","count":20},{"id":"GO:0070527","count":20},{"id":"GO:0097477","count":20}]},{"hash":"102824154124108748","title":"Actin Remodeling at Junctions and Polarity","description":"This cluster centers on actin cytoskeleton dynamics and cell-cell interfaces: filopodium and actin filament assembly/branching, Rac and small GTPase signaling, and processes establishing epithelial polarity and bicellular tight junctions. The inclusion of ephrin and T cell receptor signaling suggests broader signaling that interfaces with cytoskeletal remodeling, but the core theme is actin-driven junction formation and polarity.","confidence":"High","size":24,"edges":9,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070830","count":8},{"id":"GO:0046847","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0090135","count":8},{"id":"GO:0090263","count":8}]},{"hash":"2164131477289911159","title":"Neural development and synaptic signaling","description":"This cluster is driven by GO terms focused on nervous system and brain development, regulation of synaptic vesicle exocytosis, and signaling pathways (Robo/axon guidance and ERK cascade). While a few terms pertain to other developmental processes (e.g., T cell signaling, ossification), the preponderance of neural-related functions suggests a core theme of neural development and synaptic communication.","confidence":"Medium","size":24,"edges":232,"triangles":1237,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":9},{"id":"GO:2000300","count":8},{"id":"GO:0010796","count":8},{"id":"GO:0031384","count":8},{"id":"GO:0035385","count":7}]},{"hash":"2246765787555042097","title":"Neural development and synaptic function","description":"The cluster is enriched for neural-related processes: Schwann cell development, axonogenesis, visual perception, and excitatory postsynaptic potential point to neuronal development and synaptic activity as the core theme, with additional but less dominant signals related to cell cycle or other development processes.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":14},{"id":"GO:0043065","count":14},{"id":"GO:0014044","count":14},{"id":"GO:0010800","count":14},{"id":"GO:0007275","count":14}]},{"hash":"26818034874700224","title":"Mitochondrial translation and apoptosis","description":"The cluster foregrounds mitochondrial functions: translation (GO:0006412), protein import into the mitochondrial matrix (GO:0030150), and cytochrome c\u2013related apoptotic signaling (GO:0090200, GO:0006919, GO:002 signalling). The presence of hypoxia response (GO: cellular response to hypoxia) and neuron apoptotic processes, plus mitochondrial-associated heme biosynthesis (GO:0006782, GO:0009234) and tRNA methylation, suggests a cohesive mitochondrial context combining protein synthesis, import, metabolic maturation (heme/porphyrin), and apoptosis regulation. The antibiotic response term can reflect mitochondrial ribosome similarity to bacterial ribosomes, which can be impacted by antibiotics. Overall, this points to a mitochondria-centric cluster centered on translation, import, and apoptosis. ","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0046677","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0006919","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1733317536847222508","title":"Sex hormone and prostaglandin biosynthesis","description":"Cluster centers on lipid hormone production and signaling relevant to female reproduction: prostaglandin biosynthesis, cholesterol/androgen metabolism, and sex differentiation. The presence of prostaglandin biosynthetic terms together with female reproductive development terms (gonad/genitalia development, sex differentiation, maternal process) suggests proteins involved in lipid hormone pathways and reproductive signaling, making this a cohesive functional group.","confidence":"High","size":24,"edges":45,"triangles":24,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":17},{"id":"GO:0042904","count":16},{"id":"GO:0008585","count":16},{"id":"GO:0060137","count":15},{"id":"GO:0010164","count":15}]},{"hash":"1261541600870537245","title":"Central carbon metabolism and amino acid catabolism","description":"Most terms describe carbon/energy metabolism (gluconeogenesis; oxaloacetate and alanine catabolism) and various amino acid pathways (lysine, kynurenine, tryptophan), plus Fe-S cluster biogenesis and a cAMP response. The Notch signaling term is an outlier; overall the cluster is best characterized by metabolism, with a moderate level of uncertainty due to the signaling term.","confidence":"Medium","size":24,"edges":275,"triangles":2002,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":8},{"id":"GO:0007219","count":8},{"id":"GO:0097053","count":8},{"id":"GO:0042853","count":8},{"id":"GO:0006094","count":7}]},{"hash":"1880914704846836019","title":"Glycolysis and TCA Cycle","description":"Proteins in this cluster are dominated by core energy metabolism terms, including glycolytic process and the tricarboxylic acid cycle, pointing to central carbon metabolism as the main theme. Other terms such as circadian rhythm and growth-factor signaling support a broader link to metabolic regulation, though some entries (e.g., insect pigmentation, Leydig differentiation, archaea biosynthesis) may reflect annotation noise. Overall, the cluster seems best described by energy production pathways.","confidence":"Medium","size":24,"edges":148,"triangles":362,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":7},{"id":"GO:0006096","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0048082","count":4},{"id":"GO:0010259","count":4}]},{"hash":"1682946156138247191","title":"Neural signaling and stress-related tissue remodeling","description":"Top GO terms point to neural signaling processes such as regulation of glutamate uptake and neural fold formation, alongside transcriptional regulation and circadian gene expression. The presence of stress and remodeling terms (hypoxia signaling, corticosterone response, wound healing, elastin metabolism) suggests a module that links neural function with stress response and extracellular matrix remodeling.","confidence":"Medium","size":24,"edges":109,"triangles":452,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051946","count":15},{"id":"GO:0097411","count":15},{"id":"GO:0002248","count":15},{"id":"GO:0006366","count":15},{"id":"GO:0021502","count":15}]},{"hash":"131639100117852338","title":"DNA replication and developmental signaling","description":"The top GO terms cluster around DNA replication, centrosome cycle, and DNA-templated transcription, indicating a core function in cell cycle regulation. Developmental processes such as embryonic cranial skeleton morphogenesis and dendrite morphogenesis are also prominent, suggesting roles in development; immune signaling terms (T cell receptor signaling, cellular responses to LPS and GM-CSF) point to broader signaling roles in immune contexts. Overall, this cluster seems centered on DNA replication/cell cycle control with developmental and signaling connections.","confidence":"Medium","size":24,"edges":19,"triangles":5,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0010571","count":22},{"id":"GO:0007098","count":22},{"id":"GO:0006260","count":22},{"id":"GO:0048701","count":22},{"id":"GO:0050852","count":21}]},{"hash":"781892073780585572","title":"NF-kappaB\u2013mediated immune regulation","description":"This cluster centers on NF-kappaB signaling and cytokine control in immune responses, with terms for negative regulation of cytokine production and IL-1\u03b2, non-canonical NF-kappaB signaling, LPS response, and antiviral defense, plus selective modulation of B and T cell proliferation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050713","count":4},{"id":"GO:1900016","count":4},{"id":"GO:0002230","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0042347","count":4}]},{"hash":"1791914194578782305","title":"Axonogenesis and neural development signaling","description":"The proteins cluster around neural development and axon growth regulation. Top GO terms include positive regulation of axonogenesis and neurogenesis, regulation of axon extension and regeneration, and RTK signaling (cell surface receptor protein tyrosine kinase), PI3K/AKT signaling, and BMP signaling\u2014all pathways tied to neurite outgrowth and neuronal differentiation. The paranode axon localization term further supports an axon-domain\u2013specific role. Collectively, this suggests a cohesive function in neural development and axon growth signaling.","confidence":"High","size":24,"edges":263,"triangles":1796,"max_degree":23,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048692","count":17},{"id":"GO:1902997","count":17},{"id":"GO:0050772","count":17},{"id":"GO:0050925","count":17},{"id":"GO:0007169","count":17}]},{"hash":"376514452507893023","title":"Actin cytoskeleton remodeling and endocytosis","description":"This cluster is dominated by GO terms tied to actin dynamics and trafficking, including positive regulation of Arp2/3-mediated actin nucleation, actin cortical patch assembly, actin crosslink formation, and endocytosis, suggesting a cohesive theme around actin remodeling and internalization. While signaling terms (GTPase activity, tyrosine phosphorylation) and other processes (TGF-beta response, heart development, apoptosis) appear, the strongest and most frequent signals point to cytoskeletal regulation and related endocytic activity.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0071560","count":8},{"id":"GO:0050731","count":8},{"id":"GO:0006915","count":8},{"id":"GO:0034316","count":7}]},{"hash":"424321406930924196","title":"Cardiac muscle development and conduction","description":"The cluster shows strong enrichment for terms tied to cardiac muscle structure and electrical activity, including sarcomere organization, regulation of ventricular and atrial membrane potentials, AV node action potential, heart rate regulation, and potassium/calcium ion handling. These point to proteins involved in cardiac muscle development and the electro-mechanical coupling essential for heart conduction, with supporting signals for broader developmental processes. The bone maturation term is likely a secondary link through shared calcium signaling, but the core theme remains cardiac muscle function and conduction.","confidence":"High","size":24,"edges":13,"triangles":2,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":8},{"id":"GO:0051592","count":7},{"id":"GO:0045214","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0060307","count":7}]},{"hash":"458539103220995215","title":"Unknown","description":"Top terms span metabolism (thiamine biosynthesis) and diverse developmental processes (pituitary development, embryonic development, erythrocyte differentiation, sperm capacitation), plus several outdated terms. This mix lacks a single clear shared function, so no cohesive label can be assigned.","confidence":"","size":24,"edges":187,"triangles":747,"max_degree":23,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0009228","count":9},{"id":"GO:0009229","count":9},{"id":"GO:0021983","count":8},{"id":"GO:0045648","count":8}]},{"hash":"339640665040612927","title":"Neuronal development and synaptic vesicle trafficking","description":"The cluster is dominated by GO terms for brain and nervous system development, long-term synaptic potentiation, and regulation of synaptic vesicle exocytosis, along with intracellular and Golgi-to-plasma membrane transport, pointing to a module involved in neuronal development and synaptic vesicle trafficking.","confidence":"High","size":24,"edges":103,"triangles":89,"max_degree":18,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0006886","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0015031","count":3},{"id":"GO:2000300","count":3}]},{"hash":"487638487961254040","title":"ERAD Proteostasis and Oxidative Stress Response","description":"This cluster is dominated by terms for protein deubiquitination and ER-associated degradation (ERAD), including maintenance of unfolded ER proteins, plus responses to oxidative and light-related stress (hydrogen peroxide, UV/light). Together these suggest a cohesive function in ubiquitin-mediated protein quality control within the endoplasmic reticulum and related stress responses, with some lens/eye development associations reflected in the tissue-specific terms. ","confidence":"High","size":24,"edges":252,"triangles":1750,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":6},{"id":"GO:0030433","count":4},{"id":"GO:1904378","count":4},{"id":"GO:0010950","count":4},{"id":"GO:0009644","count":4}]},{"hash":"451721964132069711","title":"Cytoskeleton remodeling and cell junction assembly","description":"The dominant signals are membrane- and cytoskeleton-related processes: bicellular tight junction assembly, filopodium assembly, and post-translational targeting to membranes, all pointing to cell\u2013cell junctions and cytoskeletal remodeling. While there are other terms present (DNA replication, innate immune response, neuron development), the strongest theme centers on junctional organization and cytoskeletal dynamics that underlie cell adhesion and membrane trafficking. Confidence: Medium","confidence":"","size":24,"edges":57,"triangles":36,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070830","count":6},{"id":"GO:0070389","count":5},{"id":"GO:1900035","count":5},{"id":"GO:0090084","count":5},{"id":"GO:0006260","count":5}]},{"hash":"1254901579663916692","title":"Bacterial sporulation and antibiotic biosynthesis","description":"The cluster's top GO terms strongly emphasize bacterial life-cycle processes and secondary metabolism, notably sporulation (cellular spore formation) and antibiotic biosynthetic pathways, which suggest a functional theme around bacterial development and production of secondary metabolites. Supporting terms hint at broader lipid and steroid-related metabolism, indicating a versatile metabolic repertoire often associated with actinomycete-like organisms that couple primary metabolism with secondary metabolite production. Some terms (e.g., host-mediated suppression of symbiont invasion) reflect host-microbe interactions but do not diminish the central signal of sporulation and antibiotic biosynthesis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0030435","count":3},{"id":"GO:0046597","count":3},{"id":"GO:1902321","count":2},{"id":"GO:0008209","count":2}]},{"hash":"1824361444053679330","title":"Neurodevelopment and Cell-Cell Adhesion Signaling","description":"The cluster\u2019s strongest signals are neural development (neuron projection development, ventricular zone neuroblast division, nervous system development) and cell-cell adhesion (heterophilic and homophilic adhesion), with additional, less central links to chemotaxis, ossification, and complement activation, suggesting a primary theme of neural development coordinated with adhesion mechanisms.","confidence":"Medium","size":24,"edges":6,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0014068","count":13},{"id":"GO:0006958","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0050927","count":12}]},{"hash":"1583435228464480686","title":"Developmental differentiation proteins","description":"The top GO terms are dominated by development- and differentiation-related processes (fat cell differentiation, skin development, spinal cord development, multicellular organism development) with additional signals of development-related regulation (positive regulation of GTPase activity, synaptic plasticity). Some terms are old/obsolete, which may reflect outdated annotations or broad functional assignments. Overall, the cluster appears to group proteins linked to cell-type specification and organismal development rather than a single molecular function, justifying the label \"Developmental differentiation proteins.\"","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0045444","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0043588","count":4}]},{"hash":"2109415888241788996","title":"Vesicular trafficking and exocytosis","description":"The majority of top GO terms point to intracellular transport involving the Golgi, endosomes, lysosomes, and the plasma membrane, including Golgi-to-plasma membrane transport, general protein transport, endosome-to-lysosome trafficking, and exocytosis. Positive regulation of GTPase activity aligns with the control of vesicle trafficking, suggesting a cohesive role for this cluster in membrane trafficking and secretion, despite a few outlier terms like subtelomeric heterochromatin formation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0043001","count":4},{"id":"GO:0015031","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0000042","count":3}]},{"hash":"1420635054760924124","title":"Erythrocyte NO signaling and oxidative stress responses","description":"Top terms converge on erythrocyte function, particularly nitric oxide transport and biosynthesis regulation, responses to hypoxia and nitrosative/oxidant stress, and gas/bicarbonate handling; these features define red blood cell gas transport and redox homeostasis.","confidence":"High","size":24,"edges":136,"triangles":431,"max_degree":21,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0007596","count":9},{"id":"GO:0043353","count":9},{"id":"GO:0042542","count":9},{"id":"GO:0030185","count":9},{"id":"GO:0098869","count":9}]},{"hash":"720397520674295074","title":"GTPase-Driven Filopodium Dynamics","description":"The top GO terms converge on filopodium assembly and its regulation, along with small GTPase\u2013mediated signal transduction and regulation of GTPase activity, indicating proteins that drive actin-based protrusions and cytoskeletal remodeling. The presence of adhesion/cell spreading terms supports a role in adhesion-dependent protrusion formation, consistent with filopodial dynamics. While some terms touch broader signaling and development contexts (mitochondrial fission, neuronal signaling, heart development, T cell signaling), the core function across the cluster appears to be GTPase-regulated control of filopodia and related cell spreading. ","confidence":"High","size":24,"edges":32,"triangles":0,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046847","count":18},{"id":"GO:0007264","count":18},{"id":"GO:1900026","count":18},{"id":"GO:0051489","count":15},{"id":"GO:0045792","count":15}]},{"hash":"939180947009192595","title":"Developmental morphogenesis and apoptosis signaling","description":"The cluster centers on processes like apoptotic regulation and mitochondrial membrane permeabilization, paired with developmental facets such as epithelial cell migration, posterior head segmentation, and regulation of oskar mRNA translation, plus integrin-mediated signaling and collagen fibril organization. This points to a cohesive theme of developmental morphogenesis intertwined with controlled cell death and cell-ECM interactions. Some terms (innate immune response, bone development) are peripheral but can fit broader developmental signaling contexts.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0007427","count":5},{"id":"GO:1902108","count":5},{"id":"GO:0035289","count":5},{"id":"GO:0046011","count":5}]},{"hash":"1617253643994365242","title":"Rac-driven cytoskeletal remodeling and cell migration","description":"The top GO terms cluster around Rac signaling and actin-based protrusions (lamellipodium and filopodium assembly), with positive regulation of cell spreading and dendrite morphogenesis, pointing to dynamic cytoskeletal remodeling and motility. Additional terms on tight junctions and tissue homeostasis reflect coordinated cell\u2013cell interactions during morphogenesis, while ubiquitination suggests regulatory control. Overall, the dominant theme is actin-driven motility and morphogenesis.","confidence":"High","size":24,"edges":137,"triangles":278,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016601","count":9},{"id":"GO:1900026","count":9},{"id":"GO:0010592","count":8},{"id":"GO:0001889","count":8},{"id":"GO:0048873","count":8}]},{"hash":"2097240444967639412","title":"Spliceosome-driven mRNA splicing machinery","description":"The top GO terms are dominated by spliceosome-mediated mRNA splicing, splice site recognition, and subunit/processome assembly, with both alternative and regulated splicing represented. A few terms also touch on preinitiation complex formation and initiation factor assembly, suggesting broader involvement in early mRNA processing and translation readiness. Overall, the cluster aligns with components of the splicing machinery and associated mRNA processing steps.","confidence":"High","size":24,"edges":16,"triangles":5,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0034462","count":6},{"id":"GO:0006376","count":6},{"id":"GO:0097010","count":6},{"id":"GO:0006378","count":6}]},{"hash":"211500594215621184","title":"GTPase-regulated endocytosis and signaling","description":"The strongest signals are positive regulation of GTPase activity and processes tied to receptor internalization and clathrin-mediated endocytosis (GPCR internalization, endocytosis), plus insulin signaling, pointing to a core function in regulated receptor trafficking and downstream signaling. The presence of ubiquitination, JNK regulation, apoptosis, and innate immune terms suggests these proteins participate in broader signal transduction and stress responses that intersect with endocytic pathways, indicating a cohesive GTPase-regulated endocytosis and signaling module rather than unrelated functions.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0016567","count":3}]},{"hash":"1919842472505608236","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":55,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006620","count":7},{"id":"GO:0051083","count":7},{"id":"GO:0045112","count":2},{"id":"GO:2000590","count":2},{"id":"GO:0071230","count":2}]},{"hash":"303001985840224235","title":"Neuronal synaptic signaling and plasticity","description":"This cluster centers on neuronal signaling processes: exocytosis, receptor clustering, and receptor guanylyl cyclase pathways point to synaptic transmission, while regulation of Rho signaling and dephosphorylation reflect cytoskeletal and signaling modulation underlying synaptic plasticity (e.g., LTD). The related spinal cord development and behavior terms (social and exploration behavior) further support a nervous-system\u2013level theme, suggesting these proteins participate in synaptic function and plasticity in the nervous system.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:2000009","count":5},{"id":"GO:0035176","count":5},{"id":"GO:0006887","count":4},{"id":"GO:0060292","count":4}]},{"hash":"961351117013144574","title":"Nuclear RNA processing and ribosome biogenesis","description":"Most terms cluster around nuclear gene expression: mRNA splicing via spliceosome, small-subunit processome assembly, and ribosomal large subunit export, which together point to RNA processing and ribosome biogenesis. Additional terms touch on DNA replication initiation and transcriptional regulation, and a few developmental terms may reflect tissue-specific roles. Overall, the core theme is nuclear RNA processing and ribosome assembly.","confidence":"Medium","size":24,"edges":32,"triangles":1,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":4},{"id":"GO:0030097","count":3},{"id":"GO:0045071","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0003007","count":3}]},{"hash":"2028493891952589190","title":"Spliceosome-driven mRNA processing and translation initiation","description":"The cluster is dominated by GO terms about mRNA splicing via the spliceosome, spliceosome assembly, splice-site recognition, and regulation of alternative splicing, plus formation/assembly of translation initiation complexes. This points to a cohesive role in post-transcriptional mRNA processing and the early steps of translation initiation, with a stress-related angle on mRNA stability. ","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0045292","count":17},{"id":"GO:0006378","count":17},{"id":"GO:0000381","count":17},{"id":"GO:0034462","count":16}]},{"hash":"7895936717361525","title":"Neuronal GPCR signaling and drug responses","description":"The cluster is dominated by neural signaling terms: dopaminergic synaptic transmission, sensory perception, and visual learning, plus GPCR signaling pathways and phosphorylation events. Several terms reflect drug-evoked behaviors (morphine, cocaine) and prostaglandin responses, suggesting a cohesive theme of neuronal signal transduction linked to drug- and stimulus-induced behaviors. While a minor term relates to immune cell chemotaxis, the prevailing function centers on neuronal signaling and drug responsiveness.","confidence":"High","size":24,"edges":153,"triangles":344,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0001963","count":14},{"id":"GO:0071380","count":14},{"id":"GO:0043278","count":14}]},{"hash":"1171513575264722376","title":"Brain Development and Signaling Pathways","description":"This cluster centers on neural development and signaling: multiple terms point to brain development, Wnt signaling, inflammatory response, and cell migration, with additional emphasis on synaptic vesicle regulation. A few terms touch on telomere maintenance and chromosome localization, and spindle assembly, suggesting broader cell-cycle or maintenance roles. Overall, it represents a neurodevelopmental signaling theme with some accompanying cellular maintenance processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0032212","count":5},{"id":"GO:0070198","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0016477","count":5}]},{"hash":"256414724144740222","title":"Neural development and synaptic signaling","description":"This cluster is enriched for nervous system development, brain development, synapse assembly, and glutamatergic transmission, including sensory perception of sound. The dominant theme points to neural connectivity and synaptic communication, with terms like positive regulation of synapse assembly and glutamatergic transmission supporting a neuronal signaling role. A few terms (keratinization, angiogenesis-related) are less central and may reflect broader tissue contexts, but do not override the neural-centric cluster theme.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001955","count":4},{"id":"GO:0007416","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0035249","count":3}]},{"hash":"422941786961397732","title":"RNA Processing and Apoptotic Signaling","description":"This cluster is enriched for RNA processing and chromatin-related terms (mRNA splicing via spliceosome; maturation of SSU-rRNA; chromatin organization) alongside several apoptosis-related terms (apoptotic process; neuron apoptotic process; intrinsic apoptotic signaling in response to ER stress). A few terms touch development and neural function (hair follicle morphogenesis; vestibular reflex; single fertilization), which may reflect broader roles in development or sensory biology. Overall, the core theme appears to be RNA processing and programmed cell death, with some developmental associations.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0031069","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0060005","count":2},{"id":"GO:0000462","count":2}]},{"hash":"477104759285780705","title":"Muscle development and vesicle trafficking","description":"Most frequent terms point to muscle development (heart and smooth muscle) and to cytoskeletal/trafficking regulation (Rho GTPases, GTPase activity) with vesicle transport (endosome trafficking, lysosome organization). Together they imply a module where muscle development processes are linked to vesicle trafficking and GTPase signaling, justifying the name.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007507","count":2}]},{"hash":"144469630116352230","title":"Craniofacial and cranial neural crest development","description":"The top GO terms cluster around head and craniofacial development: palate formation, trigeminal ganglion development, neural crest formation, inner ear structures, and parasympathetic system development, with transcriptional regulation during development also represented. This points to a coherent theme of craniofacial morphogenesis and neural crest derivatives, despite some broader transcription-related terms. ","confidence":"High","size":24,"edges":38,"triangles":1,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":16},{"id":"GO:0006366","count":15},{"id":"GO:0061551","count":15},{"id":"GO:0007338","count":15},{"id":"GO:0014029","count":14}]},{"hash":"274174043410585522","title":"Apoptosis and Circadian Regulation with Splicing","description":"This cluster prominently features apoptosis-related terms (apoptotic process; positive regulation of intrinsic apoptotic signaling), circadian rhythm and its regulation, and RNA processing/splicing (RNA splicing; regulation of alternative mRNA splicing via spliceosome), along with transcription initiation and androgen receptor signaling. The mix suggests a regulatory module touching on cell fate decisions, temporal gene expression control, and RNA processing. Because the proteins appear to participate in multiple, overlapping regulatory processes rather than a single, cohesive pathway, the link is moderate rather than strong.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0030521","count":3},{"id":"GO:2001022","count":3},{"id":"GO:0008380","count":3},{"id":"GO:0000381","count":3}]},{"hash":"265706698847491479","title":"Transcriptional Regulation & Immune Signaling","description":"GO terms suggest a set of regulatory proteins linked to transcriptional control (negative regulation by RNA Pol II, histone modification, ubiquitination), development (spleen and bile duct), and innate immune/viral defense, with signaling roles (Wnt, GTPase). This points to a cohesive theme of gene expression regulation intertwined with developmental and immune signaling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0035622","count":2},{"id":"GO:0090263","count":2}]},{"hash":"304557066846207325","title":"Embryonic Development and Organ Differentiation","description":"The top GO terms cluster around developmental and differentiation processes across multiple organs (pancreas, placenta, cartilage, lens, palate) and include patterning and EMT, indicating a broad embryonic organogenesis theme rather than a single pathway.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0003323","count":10},{"id":"GO:0060707","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0035270","count":8}]},{"hash":"1756903910026570827","title":"Dopaminergic pain and temperature responses","description":"The cluster is enriched for dopaminergic synaptic transmission, pain perception, and temperature/thermogenesis terms, suggesting dopamine-mediated neural responses to nociceptive and thermal stimuli, with related cardiovascular signaling and metabolic cues.","confidence":"High","size":24,"edges":26,"triangles":1,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0002024","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0010579","count":12}]},{"hash":"385390307403750087","title":"Macrophage lipid handling and foam cell formation","description":"This cluster is dominated by GO terms tied to lipid metabolism and macrophage lipid uptake: foam cell differentiation, lipoprotein transport and cholesterol storage; plus innate immune response and endothelial activity, suggesting a coordinated role in macrophage-mediated lipid handling and vascular lipid clearance.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0010744","count":18},{"id":"GO:0030199","count":18},{"id":"GO:0031638","count":18},{"id":"GO:0042953","count":18},{"id":"GO:0010886","count":18}]},{"hash":"1877961532396918925","title":"Inflammation and coagulation with vascular signaling","description":"This cluster is dominated by GO terms for inflammatory response, blood coagulation, vasoconstriction, blood pressure regulation, LPS response, and GPCR-mediated signaling linked to vascular control, with additional signals in Rho pathway and pain perception, suggesting a coherent theme of immune-driven vascular inflammation and coagulation; the presence of an electron transport chain term adds a general metabolic context but does not override the vascular/inflammatory theme.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":24},{"id":"GO:0007596","count":24},{"id":"GO:0010579","count":24},{"id":"GO:0045907","count":24},{"id":"GO:0022900","count":24}]},{"hash":"14255546357426249","title":"Embryonic development and morphogenesis","description":"The dominant GO terms describe development and organogenesis across tissues\u2014trophoblast differentiation, epithelial-to-mesenchymal transitions in heart/cushion formation, placenta development, endocrine system and cartilage morphogenesis, left-right patterning, and hair follicle formation. This points to a module of proteins coordinating embryonic tissue formation rather than a single tissue type. A few terms related to gene expression processing (mRNA splicing, ribosomal export) appear but do not define the group's core function.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":24},{"id":"GO:0003198","count":24},{"id":"GO:0060806","count":24},{"id":"GO:0003323","count":24},{"id":"GO:0035270","count":24}]},{"hash":"1105388972694289553","title":"Signaling and neural plasticity","description":"This cluster is dominated by terms related to regulation of signaling pathways (positive regulation of GTPase activity; positive regulation of protein autophosphorylation; positive regulation of serine/threonine kinase activity) and neural plasticity (long-term memory and long-term synaptic potentiation), suggesting a core theme of signaling processes underpinning neuronal function, even though other terms (hypoxia response, mRNA transport, pigmentation, differentiation, and cell cycle) indicate broader cellular roles. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0071456","count":6},{"id":"GO:0031954","count":6},{"id":"GO:0071902","count":6},{"id":"GO:0060487","count":5}]},{"hash":"737033239950900170","title":"TGF-beta/BMP signaling regulators","description":"The top GO terms repeatedly center on regulation of TGF-\u03b2/BMP signaling and SMAD-related processes, plus cellular responses to TGF-\u03b2 stimulus, suggesting these proteins function as modulators of this pathway. A few terms (meristem identity, photosystem adjustment) seem peripheral or species-specific artifacts, but the core theme is signaling regulation, justifying a label focused on TGF-\u03b2/BMP pathway modulation.","confidence":"High","size":23,"edges":177,"triangles":809,"max_degree":20,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0030512","count":15},{"id":"GO:0046827","count":12},{"id":"GO:0071560","count":12},{"id":"GO:0010074","count":11},{"id":"GO:0030514","count":11}]},{"hash":"53925918679358402","title":"Immune Evasion and Cell Cycle Control","description":"The cluster shows enrichment for immune signaling suppression terms (negative regulation of T cell receptor signaling, suppression of JAK-STAT and interferon pathways) alongside mitotic regulation terms (mitotic chromatid biorientation, actomyosin ring maturation, exit from mitosis). The explicit symbiont-mediated suppression terms strongly support a host-immune evasion theme, while the mitosis-related terms suggest concurrent cell-cycle regulation. This combination points to a cohesive theme of immune modulation with linked cell-cycle control.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":23},{"id":"GO:0000200","count":23},{"id":"GO:0070373","count":23},{"id":"GO:0039563","count":19},{"id":"GO:0039502","count":19}]},{"hash":"238206674559477450","title":"Translation and mRNA Decay","description":"The cluster is dominated by translation-related terms (translation, initiation, termination, and regulation of translational termination) and by deadenylation-dependent mRNA decay, indicating a core association with protein synthesis and mRNA turnover. While there are related signals such as antibiotic response, glial proliferation, and even viral genome replication, the strongest and most coherent signal centers on translation machinery and post-transcriptional regulation.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":17},{"id":"GO:0046677","count":9},{"id":"GO:1902802","count":6},{"id":"GO:0000288","count":6},{"id":"GO:0006413","count":6}]},{"hash":"108700022405658337","title":"Calcium-cGMP Signaling and Sensory Perception","description":"The terms center on receptor-mediated signaling (T cell receptor signaling, TGF-beta response) and cyclic nucleotide signaling (cGMP/cAMP) with calcium regulation, plus sensory-related processes (retinal cone development, smell). This suggests a cohesive theme of signaling pathways that modulate Ca2+ and cyclic nucleotides and connect to sensory system functions (vision and olfaction).","confidence":"Medium","size":23,"edges":39,"triangles":31,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":13},{"id":"GO:0071560","count":10},{"id":"GO:0019933","count":9},{"id":"GO:0071321","count":8},{"id":"GO:0010754","count":8}]},{"hash":"691831827145371068","title":"Ubiquitin-dependent protein turnover","description":"The prevalent GO terms point to ubiquitin-mediated modification and degradation (ubiquitin-dependent protein catabolic process, polyubiquitination, K33-linked ubiquitination). Other terms (circadian rhythm regulation, phototropism/gravitropism, sarcomere organization) likely reflect broad, context-dependent roles of ubiquitin signaling across cellular processes. The common connection is ubiquitin tagging driving protein turnover.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0042752","count":12},{"id":"GO:0000209","count":8},{"id":"GO:1903265","count":7},{"id":"GO:1900242","count":7}]},{"hash":"2169151375141863417","title":"Brain dopaminergic signaling and sensory perception","description":"This cluster centers on neural signaling and sensory processing in the brain, with strong enrichment for dopaminergic synaptic transmission, pain perception, and drug-response terms (morphine, cocaine), as well as visual learning and ERK signaling, suggesting cohesive brain reward and sensory perception networks.","confidence":"High","size":23,"edges":138,"triangles":294,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":21},{"id":"GO:0001963","count":20},{"id":"GO:0071380","count":20},{"id":"GO:0043278","count":20},{"id":"GO:0048148","count":20}]},{"hash":"1472960309106959848","title":"Placental and embryonic morphogenesis","description":"The top GO terms cluster around placental and embryonic development, including trophoblast giant cell differentiation, placental development, EMT in embryogenesis, left-right pattern formation, and related morphogenetic processes. While there are a couple of general cellular-process terms (ribosomal export, DNA replication initiation), the dominant signal is developmental and morphogenesis-focused, suggesting a group of proteins involved in embryonic/placental tissue differentiation and patterning.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":17},{"id":"GO:0003198","count":17},{"id":"GO:0060806","count":17},{"id":"GO:0003323","count":17},{"id":"GO:0035270","count":17}]},{"hash":"128352192536383853","title":"Proteostasis and Organelle Biogenesis","description":"The top GO terms cluster around protein quality control and turnover (ERAD, proteasomal catabolic process, autophagosome maturation), along with protein assembly processes (hexamerization, complex III assembly, inclusion body assembly) and organelle-related maintenance (peroxisome import, mitochondrial respiration regulation, heat response). This suggests a cohesive theme of maintaining protein homeostasis across organelles, involving degradation, assembly, and stress adaptation. ","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0097352","count":2},{"id":"GO:0016562","count":2},{"id":"GO:0035617","count":2},{"id":"GO:1901800","count":2}]},{"hash":"2015955930669732336","title":"Unknown","description":"The terms span very disparate processes: hypoxia sensing and HIF-1alpha signaling, actin cytoskeleton (actin rod assembly), virion attachment to host cells, responses to drugs (cocaine), and regulatory events in plant hormone signaling, protein autophosphorylation, telomerase assembly, and metabolic regulation. There is no single coherent function or pathway linking these GO terms across the cluster, so there isn\u2019t a reliable, specific label to assign beyond Unknown.","confidence":"","size":23,"edges":46,"triangles":11,"max_degree":12,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0070483","count":3},{"id":"GO:0031247","count":3},{"id":"GO:0060334","count":3},{"id":"GO:0019062","count":3},{"id":"GO:0042220","count":3}]},{"hash":"957827506053796355","title":"Retroviral integration and latency","description":"The cluster shows strong signals for viral entry into host cells, reverse transcription (RNA-templated DNA synthesis), and DNA integration with proviral latency, all hallmarks of retroviral/proviral life cycles. While a few terms reference host-symbiont interactions, the core pattern points to viral genome integration and maintenance in the host genome.","confidence":"High","size":23,"edges":5,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0075732","count":5},{"id":"GO:0006278","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0090502","count":5}]},{"hash":"1587320236569973300","title":"Cellular stress response and proteostasis","description":"The GO terms point to a broad set of stress-related processes, including oxidative and heat stress responses, transcriptional regulation under stress, and proteasome-related assembly, along with cell cycle/spindle remodeling and ECM/immune signaling. This pattern suggests a cluster of proteins involved in maintaining cellular homeostasis under stress, rather than a single, tightly defined pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0034599","count":2},{"id":"GO:0018279","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0009408","count":2}]},{"hash":"832552679762100123","title":"Neuronal synaptic vesicle trafficking and dendrite development","description":"The cluster is dominated by terms tied to nervous system development and synaptic function, including regulation of synaptic vesicle exocytosis and endocytosis, vesicle docking, brain development, and dendrite morphogenesis. This combination points to proteins involved in neuronal communication and neurite maturation, making a label focused on synaptic vesicle trafficking and dendritic development appropriate.","confidence":"High","size":23,"edges":162,"triangles":487,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000300","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0031532","count":5},{"id":"GO:0043524","count":5},{"id":"GO:0010796","count":5}]},{"hash":"2165630428891176753","title":"Lung Morphogenesis and Bone ECM Remodeling","description":"This cluster centers on extracellular matrix remodeling and tissue morphogenesis: collagen catabolic process, basement membrane disassembly, and intramembranous ossification point to ECM turnover in bone development, while epithelial tube branching involved in lung morphogenesis supports organ development; bone resorption also aligns with remodeling processes. The immune-related term (T cell mediated cytotoxicity) is less central and may reflect ancillary immune interactions. Overall, the dominant theme is ECM remodeling linked to development in lung and bone.","confidence":"Medium","size":23,"edges":151,"triangles":677,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0001913","count":18},{"id":"GO:0045453","count":18},{"id":"GO:0060441","count":18},{"id":"GO:0035593","count":18},{"id":"GO:0034769","count":18}]},{"hash":"2034804838265897625","title":"Innate immune response and development","description":"This cluster is strongly enriched for innate immunity terms, especially Toll-like receptor signaling (TLR2 and TLR4), defense responses to Gram-positive bacteria and viruses, dsRNA response, and inflammatory processes, indicating a cohesive immune signaling theme. The presence of development-related terms (embryonic cranial skeleton morphogenesis, nervous system development, multicellular organism development) suggests these proteins may also participate in development or share regulatory pathways with immune signaling. Overall, the dominant function appears to be innate immune signaling with inflammatory responses, with development terms likely representing pleiotropy or co-regulated processes.","confidence":"Medium","size":23,"edges":9,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048701","count":10},{"id":"GO:0050830","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0071260","count":8},{"id":"GO:0043330","count":8}]},{"hash":"1718403041097980663","title":"Retroviral integration and proviral latency","description":"Top GO terms indicate core retroviral life-cycle processes: viral entry into the host nucleus, RNA-templated DNA synthesis (reverse transcription), DNA integration, and establishment of proviral latency, suggesting proteins in this cluster are tied to genome integration and latent provirus maintenance (with some related signaling terms as ancillary).","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075732","count":4},{"id":"GO:0006278","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0015074","count":4}]},{"hash":"1055224166490158658","title":"Fucosylated glycans in leukocyte and neural migration","description":"The cluster shows enrichment for glycosylation/fucosylation processes (protein glycosylation, N-glycan fucosylation, Lewis a epitope biosynthesis) alongside immune-related migration and differentiation terms (leukocyte migration, regulatory T cell differentiation). There are also neural development migration terms (cerebral cortex radial migration, neuronal stem cell maintenance). Together, this suggests a theme where fucosylated glycans modulate cell adhesion and trafficking in both immune and neural contexts. ","confidence":"Medium","size":23,"edges":25,"triangles":3,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":6},{"id":"GO:0002522","count":4},{"id":"GO:0097150","count":4},{"id":"GO:0042355","count":4},{"id":"GO:0002361","count":4}]},{"hash":"1853519643980039141","title":"Immune signaling and developmental processes","description":"The cluster is enriched for innate immune response and defense against bacteria, suggesting immune signaling roles. It also includes terms for cell adhesion and developmental remodeling, such as angiogenesis, ossification, and myelination, indicating involvement in tissue development and remodeling alongside immune functions. Overall, it points to proteins participating in immune signaling integrated with developmental processes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0000187","count":14},{"id":"GO:0042511","count":13},{"id":"GO:0042742","count":13},{"id":"GO:0032516","count":13}]},{"hash":"885134999243950238","title":"Nuclear Transport and Cell Cycle Regulation","description":"This cluster is best described by nuclear and chromosomal regulation processes: import of NLS-bearing proteins into the nucleus, proteasome localization for protein turnover, regulation of centromeric cohesion and the cell cycle, and chromatin maintenance. While a few growth/development terms appear, the strongest signal is a nuclear-centric module coordinating protein turnover, chromosome dynamics, and cell-cycle control.","confidence":"High","size":23,"edges":240,"triangles":1530,"max_degree":22,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":16},{"id":"GO:0031144","count":15},{"id":"GO:0080034","count":15},{"id":"GO:0007050","count":15},{"id":"GO:0015991","count":15}]},{"hash":"609773260084165816","title":"Organogenesis and developmental morphogenesis","description":"The cluster's top GO terms converge on organ development and morphogenesis (root development, metanephros morphogenesis, endodermal fate, maintenance of organ identity). Additional signals related to cell cycle regulation and cytoskeletal/adhesion processes commonly accompany developmental programs, supporting a theme of coordinated organ formation and identity maintenance.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":12},{"id":"GO:0048364","count":12},{"id":"GO:0003338","count":11},{"id":"GO:1904501","count":11},{"id":"GO:0048496","count":11}]},{"hash":"1643309108428972147","title":"Neural development and synaptic signaling","description":"The top terms cluster around nervous system and brain development, along with functions tied to neurons such as regulation of synaptic vesicle exocytosis and ERK/MAPK signaling. While a few terms touch on immune signaling (T cell receptor signaling, interferon production), these likely reflect shared signaling pathways rather than a primary immune function. Overall, the proteins appear enriched for neural development and synaptic communication, with MAPK signaling as a common mechanism.","confidence":"High","size":23,"edges":134,"triangles":227,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":10},{"id":"GO:0070374","count":9},{"id":"GO:0050852","count":9},{"id":"GO:2000300","count":9},{"id":"GO:0032729","count":9}]},{"hash":"144262766247968047","title":"RBC NO signaling and oxidative stress response","description":"This cluster's GO terms cover red blood cell biology (enucleate erythrocyte differentiation, bicarbonate transport, blood coagulation) together with nitric oxide transport and biosynthesis, and oxidative/redox stress responses (hydrogen peroxide, nitrosative stress, oxidant detoxification) and hypoxia response, suggesting a cohesive theme around RBC NO signaling and redox balance.","confidence":"High","size":23,"edges":93,"triangles":210,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0043353","count":3},{"id":"GO:0042542","count":3},{"id":"GO:0030185","count":3},{"id":"GO:0098869","count":3}]},{"hash":"1200778668826359676","title":"Neural Cell Fate Specification","description":"This cluster is dominated by GO terms about differentiation of neural cells across multiple CNS regions, including spinal cord motor neuron fate, cortical GABAergic interneuron differentiation, subpallium neuron fate commitment, and oligodendrocyte lineage specification, as well as transcription by RNA polymerase II suggesting regulatory programs. While a few terms like bronchiole or endocrine pancreas development appear, the strongest signal is neural development, indicating a cohesive cluster of genes involved in neuronal and glial cell fate decisions.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":19},{"id":"GO:0060435","count":13},{"id":"GO:2001038","count":13},{"id":"GO:0021520","count":13},{"id":"GO:0021530","count":13}]},{"hash":"988796587148682183","title":"NF-kappaB\u2013driven autophagy and antiviral defense","description":"The top terms point to NF-kappaB signaling regulation (canonical pathway) and autophagy with defense responses to virus, suggesting a functional theme around NF-kappaB\u2013mediated autophagy in antiviral immunity. Some developmental terms appear, but the central theme is the NF-kappaB/autophagy-immune axis rather than a single developmental process. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0006914","count":5},{"id":"GO:0051607","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0097050","count":4}]},{"hash":"1384696687344439934","title":"Spliceosome-driven mRNA processing","description":"This cluster is dominated by GO terms related to mRNA splicing and spliceosome assembly (positive/negative regulation of splicing, cis splicing, splice site recognition, processome assembly), as well as mRNA stability regulation in stress and translation preinitiation complex formation, pointing to a cohesive set of proteins involved in RNA processing and maturation with a possible link to translation initiation. ","confidence":"High","size":23,"edges":244,"triangles":1599,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0010610","count":14},{"id":"GO:0045292","count":13},{"id":"GO:0048025","count":12}]},{"hash":"1331414567785206941","title":"Mitochondrial Metabolite Transporters","description":"The GO terms emphasize transport of metabolites into and across mitochondria (iron, glycine, ornithine, alpha-ketoglutarate, malate-aspartate shuttle) and ATP translocation, pointing to a cohesive role in mitochondrial metabolite exchange and energy handling. Some terms about insulin response and pregnancy reflect broader metabolic regulation, but the dominant signal is mitochondrial transport and metabolism.","confidence":"High","size":23,"edges":61,"triangles":57,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0048250","count":14},{"id":"GO:0036233","count":14},{"id":"GO:0000066","count":14},{"id":"GO:0015742","count":14},{"id":"GO:0043490","count":14}]},{"hash":"1473273488581635811","title":"Lipid Homeostasis and Inflammation","description":"The top GO terms cluster around lipid metabolism and cholesterol handling (ceramide biosynthesis, intestinal cholesterol absorption, cholesterol homeostasis, HDL particle clearance) together with immune/inflammatory responses (inflammatory response, defense against Gram-positive bacteria). While some terms touch on clearance or development, the dominant theme is lipid processing coupled with inflammatory signaling, supporting this label.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046513","count":3},{"id":"GO:0030299","count":3},{"id":"GO:0042632","count":3},{"id":"GO:0010983","count":3},{"id":"GO:0006954","count":3}]},{"hash":"833669100423992147","title":"Neural Development and Neuropeptide Signaling","description":"The top GO terms center on nervous system development and neuronal differentiation (multicellular organism development, nervous system development, sensory perception of sound, dopaminergic neuron differentiation, neuron projection development) and include neuropeptide signaling and ERK pathway regulation, pointing to coordinated neural development and signaling processes. While there are a few terms like angiogenesis and blood pressure, the dominant signal is neural development and neuronal signaling, justifying a focused label. ","confidence":"High","size":23,"edges":113,"triangles":245,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0007218","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0070374","count":3}]},{"hash":"1557461943408506721","title":"Ribosome Biogenesis and Protein Translation","description":"The cluster\u2019s top GO terms are dominated by translation (GO:0006412) and translational initiation/termination (GO:0006413, GO:0006415) along with ribosome biogenesis (GO:0042254), indicating a strong representation of ribosomal components and protein synthesis machinery. Additional terms point to stress and immune signaling (interferon response, antiviral, toxin/antibiotic responses), which may reflect regulatory or contextual modulation of translation. Overall, the core theme is ribosome assembly and protein synthesis, with ancillary responses to stress or immune cues.","confidence":"High","size":23,"edges":251,"triangles":1729,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0045071","count":5},{"id":"GO:0009636","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0090502","count":4}]},{"hash":"2031481787737192583","title":"Mitochondrial Central Carbon Metabolism","description":"The cluster centers on acetyl-CoA and oxaloacetate metabolism, plus several organic acid catabolic pathways, and includes a term for mitochondrial respiratory chain complex IV assembly, pointing to core mitochondrial energy metabolism and central carbon metabolism. Some terms are outliers or obsolete, but the dominant theme is mitochondrial metabolism.","confidence":"Medium","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010124","count":3},{"id":"GO:0033617","count":2},{"id":"GO:0055114","count":2},{"id":"GO:1901223","count":2},{"id":"GO:0006084","count":2}]},{"hash":"940481947894117668","title":"Ubiquitin-regulated developmental morphogenesis","description":"This cluster is enriched for multiple developmental and morphogenesis terms (skeletal muscle fiber development, left/right pattern formation, placental and hair follicle development, EMT in heart formation), along with ubiquitin-related processes (protein ubiquitination and ubiquitin-dependent protein catabolic process). The overlap suggests a theme of developmental differentiation modulated by ubiquitin-mediated regulation, though one outlier term (defense response to virus) adds some noise. Overall, a coherent motif around development with ubiquitin control.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0060972","count":3}]},{"hash":"1781434116888479211","title":"Rho/Rac GTPase signaling and immune cell actin remodeling","description":"The top GO terms center on regulation of Rho, Rac, and Ras pathways and lamellipodium assembly, pointing to actin cytoskeleton remodeling driven by small GTPases. This is juxtaposed with immune processes (NK T cell differentiation, B cell maturation, IL-4/IL-7 signaling, TGF-beta response), suggesting a cluster where GTPase signaling modulates immune cell behavior and cytoskeletal dynamics.","confidence":"Medium","size":23,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0001865","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0002344","count":3}]},{"hash":"268370171220506185","title":"Broad-Spectrum Transmembrane Solute Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of diverse solutes, including vitamins, xenobiotics, various ions (K+, Na+), and sugars (galactose, fucose), plus nitrite/nitrate transport. The breadth of substrates suggests a set of membrane transporter proteins with broad specificity or a transporter family involved in uptake/efflux of multiple solutes rather than a single substrate. The annotations collectively point to a transport-oriented function across the membrane.","confidence":"High","size":23,"edges":9,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":22},{"id":"GO:0006855","count":22},{"id":"GO:0071805","count":19},{"id":"GO:0042891","count":18},{"id":"GO:0035725","count":17}]},{"hash":"662935644454675241","title":"Actin Cytoskeleton Remodeling","description":"The top terms are dominated by actin-related processes (crosslinking, filament network formation), pointing to actin cytoskeleton remodeling as the central theme. Associated signals such as muscle development, neuronal signaling (BDNF response), insulin signaling, and myelination suggest broader regulatory contexts where actin dynamics interact with development and signaling. The inclusion of mitochondrial fission regulation also ties into cytoskeletal control of organelle fission.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051764","count":3},{"id":"GO:0042694","count":2},{"id":"GO:0090140","count":2},{"id":"GO:0044397","count":2},{"id":"GO:1990416","count":2}]},{"hash":"245255694748943864","title":"LPS-driven inflammatory cytokine signaling","description":"Top terms indicate a theme of lipopolysaccharide response and cytokine regulation (IL-6, IL-8, TNF), plus defense against bacteria, suggesting an innate immune/inflammatory cluster. Some terms (neuromuscular posture, DNA damage\u2013related apoptosis) appear ancillary, but the core signal is LPS-associated immune signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0050884","count":3},{"id":"GO:0071260","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0031663","count":2}]},{"hash":"2082790158189087388","title":"Cardiac Development and Myofibril Assembly","description":"The top terms center on heart development, cardiac muscle structure (myofibril assembly), SA node action potential regulation, and stress-induced cardiac hypertrophy, indicating a cohesive cardiac-focused function for this cluster. A neural crest term is present but does not override the dominant cardiac theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055003","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0051000","count":3}]},{"hash":"360423258355145657","title":"Gene Expression Machinery and Endolysosomal Trafficking","description":"The top GO terms cluster around translation initiation (formation of translation preinitiation complex, IRES-dependent initiation, regulation of initiation) and transcription elongation, pointing to gene expression processes. There are also hints of chromatin modification (histone deubiquitination) and protein trafficking/lysosomal targeting (lysosome targeting, endosome-to-lysosome transport) among the terms, suggesting a broader link between gene expression machinery and intracellular trafficking. While not perfectly unified, the most coherent theme is gene expression regulation coupled with protein processing/trafficking pathways. Confidence: Medium","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0006354","count":3},{"id":"GO:0035522","count":3}]},{"hash":"1658250358742469242","title":"Neuronal Rho-GTPase signaling and spine morphogenesis","description":"The cluster is dominated by GO terms linking Rho GTPase signaling, its regulation, and actin cytoskeleton remodeling, together with dendritic spine morphogenesis and receptor clustering. This points to a cohesive theme of neuronal synaptic architecture and cytoskeletal dynamics governing spine formation and signaling, with sensory (sound) and grooming behavior terms supporting a neuronal context.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0007605","count":12},{"id":"GO:0007266","count":11},{"id":"GO:0035023","count":11},{"id":"GO:0043113","count":11},{"id":"GO:2000821","count":11}]},{"hash":"498305665978285286","title":"Multitissue Development and Cell Adhesion","description":"The 23 proteins span different organ systems but cluster around developmental differentiation and adhesion/polarization themes (germinal center B cell differentiation, nephron/ureter development, radial glial differentiation, and various cell\u2013cell adhesion/localization terms). This suggests a broad role in tissue morphogenesis rather than a single pathway, justifying a cross-tissue developmental label.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002314","count":23},{"id":"GO:0097118","count":23},{"id":"GO:0060019","count":23},{"id":"GO:0072006","count":23},{"id":"GO:0045176","count":23}]},{"hash":"1116223411537718648","title":"Sensory signaling and metabolic regulation","description":"The top GO terms point to sensory perception (pain and vision) and GPCR/ERK signaling, with accompanying metabolic and vascular-related processes (thermogenesis, electron transport chain, blood pressure, prostaglandin response). This suggests a cluster of proteins involved in neural sensory signaling that is tied to energy metabolism and physiological regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0007190","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0045777","count":13}]},{"hash":"265236431619030891","title":"Coagulation and ECM Remodeling","description":"This cluster is enriched in blood coagulation, complement activation, and ECM catabolic processes (collagen and elastin), with angiogenesis regulation, pointing to vascular remodeling and extracellular matrix turnover as the unifying theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0030574","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0044130","count":6}]},{"hash":"674923899914821916","title":"Developmental transcriptional regulation","description":"The Top Terms show transcription-related GO terms (negative regulation of transcription by RNA polymerase II; DNA-templated transcription) alongside diverse embryonic organogenesis terms (pituitary gland development, roof of mouth development, midbrain development, neural crest cell migration, odontogenesis, embryonic hindlimb morphogenesis, ureteric bud branching). This pattern suggests proteins that participate in regulating transcription during development across multiple tissues, indicating a broad developmental role rather than a single tissue-specific pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0021983","count":6},{"id":"GO:0060021","count":6},{"id":"GO:0030901","count":5},{"id":"GO:0006351","count":5}]},{"hash":"671796238938788563","title":"Organogenesis and cell adhesion","description":"The terms point to broad developmental differentiation across multiple organs (neural, kidney/ureter, vasculature) with a common thread in adhesion and cell polarity (homophilic and calcium-dependent adhesion, apical localization) and neural maturation processes, suggesting a cluster of proteins involved in organogenesis and tissue morphogenesis through adhesion mechanisms. ","confidence":"Medium","size":23,"edges":37,"triangles":0,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":23},{"id":"GO:0002314","count":21},{"id":"GO:0097118","count":21},{"id":"GO:0060019","count":21},{"id":"GO:0072006","count":21}]},{"hash":"1354725190030336657","title":"Axon Guidance and Neural Development","description":"The top GO terms cluster around neural development and axon pathfinding: axonal fasciculation, sympathetic neuron projection guidance and extension, branchiomotor neuron axon guidance, trigeminal nerve structure, neural crest cell migration, and semaphorin-plexin signaling involved in axon guidance, along with myelination and related neural differentiation processes. These collectively indicate a program of neural crest\u2013derived neuron development and axon navigation, with skeletal system development reflecting cranial neural crest derivatives. The obsolete PI3K regulation term is less informative but does not override the clear neural development theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":13},{"id":"GO:0007413","count":12},{"id":"GO:0021637","count":11},{"id":"GO:0097490","count":11},{"id":"GO:0021785","count":11}]},{"hash":"828160581347185466","title":"Wnt-Integrin Signaling for Angiogenesis and Migration","description":"The top terms point to Wnt and integrin signaling driving angiogenesis, along with actin cytoskeleton remodeling and processes tied to cell movement and polarity; together these imply a cohesive role in promoting new blood vessel formation via migratory, polarized cells. Some terms are broader or peripheral (phagocytosis, IGF response), but the dominant themes support pro-angiogenic signaling and cell migration. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0090162","count":2}]},{"hash":"1175740629202075588","title":"Dopaminergic Reward and Feeding Signaling","description":"This cluster is dominated by GO terms tied to dopaminergic synaptic transmission, GPCR signaling with a cGMP second messenger, and behavioral readouts such as sensitization and eating behavior, pointing to dopamine-driven reward pathways that regulate feeding. While a few terms like heat generation or defense responses are present, the central theme is dopamine-mediated neural signaling in reward/feeding contexts.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":21},{"id":"GO:0042755","count":21},{"id":"GO:0001963","count":21},{"id":"GO:0007199","count":21},{"id":"GO:1900134","count":21}]},{"hash":"987507886590569270","title":"Vascular Activation and Locomotion Regulation","description":"The terms cluster around endothelial activation, platelet activation, fibrinolysis, and lipid clearance (chylomicron remnant), plus locomotory and neuromuscular processes and JNK signaling regulation. This points to a module related to vascular/hemostatic signaling intertwined with movement control, with ribosome biogenesis as a general background function. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042118","count":3},{"id":"GO:0050884","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0008344","count":2}]},{"hash":"2172569920837460891","title":"Ubiquitin-Dependent Growth and Signaling Regulation","description":"The top GO terms are dominated by ubiquitination and ubiquitin\u2011dependent protein catabolic processes, indicating a core theme of protein turnover. Additional terms point to growth signaling, innate immunity, integrin signaling, and transcription, suggesting a cluster of proteins that regulate signaling and growth through ubiquitin\u2011driven mechanisms.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0046621","count":5},{"id":"GO:0060396","count":5},{"id":"GO:0051549","count":4}]},{"hash":"1774920250529717966","title":"Rho-Driven Actin Cytoskeleton and Contractile Ring","description":"The top terms point to Rho GTPase signaling and regulation of GTPase activity, along with actin filament bundle assembly in the mitotic contractile ring, indicating a cohesive mechanism of cytoskeletal dynamics and actomyosin contractility driven by Rho pathways. While a few annotations are obsolete or veer toward other processes (spermatogenesis, myelination, IL-1 response), the shared theme is cytoskeletal organization and contractile ring assembly during cell division.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090286","count":3},{"id":"GO:0035023","count":3},{"id":"GO:1903477","count":3},{"id":"GO:0070493","count":3},{"id":"GO:0043087","count":3}]},{"hash":"1584303090254621593","title":"Dopaminergic signaling and inflammatory responses","description":"The top GO terms are dominated by dopaminergic signaling, including synaptic transmission and adenylate cyclase-activating dopamine receptor signaling, indicating a core theme of dopamine-mediated neural communication. Additional enrichment in inflammatory and cardiovascular processes (blood coagulation, TNF regulation, neutrophil chemotaxis, prostaglandin response) alongside behavioral aspects (eating behavior, sensitization) suggests the cluster links dopamine signaling to immune/CV functions and reward-related behaviors. Overall, the dominant pattern is dopaminergic signaling with associated inflammatory and cardiovascular context.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":14},{"id":"GO:0007596","count":14},{"id":"GO:0032720","count":14},{"id":"GO:0090023","count":14},{"id":"GO:0008283","count":14}]},{"hash":"761814795400325903","title":"Cardiovascular development and cardiac contraction","description":"This cluster centers on cardiovascular development and function, with GO terms related to vascular smooth muscle cell regulation, vasculogenesis, Rho signaling, sarcomere organization, and cardiac muscle contraction (including heart rate modulation by epinephrine). While a couple terms are outliers, the dominant themes point to vascular remodeling and cardiac muscle structure and activity.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904753","count":3},{"id":"GO:1904706","count":3},{"id":"GO:0007266","count":2},{"id":"GO:0001570","count":2},{"id":"GO:0060298","count":2}]},{"hash":"265084834822499684","title":"Neural and Eye Morphogenesis","description":"The top GO terms point to brain and eye developmental processes (pituitary gland development, midbrain development, brain segmentation, embryonic eye morphogenesis, camera-type eye development) and include transcription by RNA polymerase II, indicating regulatory factors directing neural/ocular morphogenesis. This suggests a cohesive cluster of proteins involved in neural and visual system development and its transcriptional control.","confidence":"High","size":22,"edges":13,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":11},{"id":"GO:0060441","count":10},{"id":"GO:0006366","count":10},{"id":"GO:0048048","count":10},{"id":"GO:0043010","count":10}]},{"hash":"1078587276938944560","title":"Mitotic spindle and microtubule dynamics","description":"The top terms converge on microtubule cytoskeleton organization and mitotic processes, including metaphase chromosome alignment, spindle elongation, minus-end\u2013directed sliding, and cytokinesis, indicating a cohesive module focused on microtubule-based dynamics during cell division and related development. Some terms also reflect broader cytoskeletal roles in stress granule disassembly and neurite maintenance.","confidence":"High","size":22,"edges":73,"triangles":144,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0001560","count":14},{"id":"GO:0007080","count":14},{"id":"GO:0030951","count":14},{"id":"GO:0072092","count":14},{"id":"GO:0000911","count":14}]},{"hash":"1445470338995116122","title":"Embryonic organogenesis and muscle differentiation","description":"The GO terms cluster around transcriptional regulation and diverse embryonic development processes, including skeletal muscle differentiation, heart field specification, lung/airway cartilage development, and primitive streak formation. This pattern suggests a group of proteins coordinating early embryonic tissue patterning and differentiation, especially mesoderm-derived muscle and respiratory tract structures.","confidence":"High","size":22,"edges":205,"triangles":1110,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0035914","count":7},{"id":"GO:2001016","count":7},{"id":"GO:0003139","count":7}]},{"hash":"400924044068385808","title":"Splicing and Translation Initiation Machinery","description":"The top GO terms show strong representation of mRNA splicing via spliceosome (cis splicing, splice site recognition, small-subunit processome assembly, regulation of splicing) and translation initiation (preinitiation complex formation, eIF4F complex assembly, translation reinitiation), with related mRNA stability regulation under stress. This points to a cluster of proteins involved in both RNA processing and initiation of translation, i.e., spliceosome/splicing regulators and translation initiation components working together. High","confidence":"","size":22,"edges":54,"triangles":42,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":12},{"id":"GO:0006378","count":12},{"id":"GO:0001731","count":11},{"id":"GO:0048025","count":11},{"id":"GO:0002188","count":11}]},{"hash":"63279320226516377","title":"Embryonic development and organogenesis","description":"The terms point to multiple embryonic differentiation and organ formation processes\u2014from placental lineage (trophoblast giant cell differentiation, placental development) to heart development (EMT in endocardial cushion), craniofacial (roof of mouth, cartilage morphogenesis), axis formation (left/right patterning), and endocrine organs (pancreatic and endocrine system development). Together they define a cohesive theme of embryogenesis and organogenesis rather than a single, isolated pathway.","confidence":"High","size":22,"edges":24,"triangles":1,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":18},{"id":"GO:0003198","count":18},{"id":"GO:0060806","count":18},{"id":"GO:0003323","count":18},{"id":"GO:0035270","count":18}]},{"hash":"2161309292657418536","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"The top GO terms cluster around neural and sensory functions: pain perception, visual perception and learning, dopaminergic synaptic transmission, and cocaine-related behavior, along with signaling cascades (ERK1/ERK2) and membrane potential regulation. This suggests a cohesive theme of neuronal signaling, sensory processing, and drug-responsive pathways, with some peripheral terms like heart development likely reflecting broader expression patterns rather than core cluster function. ","confidence":"High","size":22,"edges":206,"triangles":1099,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0071380","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0007507","count":13}]},{"hash":"53273867685507810","title":"Regulated signaling, actin dynamics, and RNA processing","description":"These proteins appear enriched for diverse cellular regulatory processes, including cytoskeletal regulation (negative regulation of Arp2/3 complex-mediated actin nucleation), signaling and phosphorylation (positive regulation of GTPase activity, serine/threonine kinase activity, and autophosphorylation), stress response (cellular response to hypoxia), and core RNA processing and ribosome biogenesis (mRNA transport, mRNA splicing, ribosome biogenesis), plus cell cycle and fertilization-related terms. The common theme is broad regulation of cellular functions rather than a single pathway, which justifies a label focused on regulatory roles across signaling, cytoskeleton, and RNA processing. Confidence is Moderate because the term set spans multiple distinct processes with only a loose unifying theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034316","count":8},{"id":"GO:0071456","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0031954","count":6},{"id":"GO:0051028","count":6}]},{"hash":"1946808834512058979","title":"Deubiquitination-driven transcription and DNA repair","description":"Top GO terms cluster around ubiquitin-specific deubiquitinases and ubiquitin-dependent regulation, linking processes such as K48- and K11-linked deubiquitination, histone H2A deubiquitination, DNA-templated transcription, DNA repair, and RNA splicing. This points to a coherent role in chromatin regulation and transcriptional control via deubiquitination mechanisms. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0071108","count":3},{"id":"GO:0006511","count":3},{"id":"GO:0010950","count":2},{"id":"GO:0070537","count":2}]},{"hash":"625815190212178083","title":"Ubiquitin signaling regulators","description":"The cluster is defined primarily by GO terms for protein ubiquitination and deubiquitination (including K6- and K29-linked), with additional hints of post-translational modification and NFAT/inflammatory signaling, and some developmental associations. This suggests a cohesive theme around ubiquitin-mediated regulation rather than a single specific pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060065","count":3},{"id":"GO:0050774","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051531","count":3},{"id":"GO:0016567","count":3}]},{"hash":"325138500792212513","title":"Cell-surface signaling in neurons and vascular/ECM regulation","description":"The prominent GO terms point to cell-surface localization and exocytosis with neural signaling (glutamatergic transmission) and concurrent regulation of extracellular matrix and vascular processes (collagen fibril organization, angiogenesis, vascular permeability). This suggests a cohesive group of surface proteins that modulate neuronal communication while also influencing endothelial/ECM dynamics, fitting a neurovascular signaling cluster with immune-related hints (complement activation). ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0034394","count":5},{"id":"GO:0051968","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0043116","count":5},{"id":"GO:2000352","count":5}]},{"hash":"952013214773982306","title":"Coagulation and ECM Remodeling","description":"The top GO terms cluster around blood coagulation, fibrinolysis, and collagen fibril organization, with regulation of plasminogen activation and acute-phase response as supporting signals. This suggests a cohesive theme of hemostasis and extracellular matrix remodeling, potentially related to wound healing or vascular tissue maintenance. Some development terms may reflect shared ECM roles in craniofacial tissues, but the core pattern centers on coagulation and matrix dynamics.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:0030199","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0042730","count":4},{"id":"GO:0006953","count":4}]},{"hash":"1955163354109508128","title":"Embryonic organogenesis and patterning","description":"This cluster shows transcription-related GO terms (transcription by RNA polymerase II and negative regulation of transcription) together with numerous morphogenesis terms across multiple tissues and processes (neural crest migration, pancreas development, ureteric bud and lung branching, digestive tract morphogenesis, left-right patterning, roof of mouth development, skeletal muscle development). The combination points to a coordinated developmental program governing organogenesis and body axis patterning, with transcriptional regulation as a central mechanism.","confidence":"Medium","size":22,"edges":47,"triangles":20,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0006366","count":6},{"id":"GO:0001755","count":5},{"id":"GO:0031018","count":5},{"id":"GO:0090190","count":5}]},{"hash":"1745100232893715766","title":"RNA processing and translation initiation","description":"This cluster is dominated by GO terms related to translation initiation (preinitiation complex formation, initiation and reinitiation, IRES-dependent initiation) and RNA processing/splicing (spliceosome, small-subunit processome, polyadenylation, splicing regulation). The shared theme appears to revolve around RNA metabolism from processing to the initiation of translation, indicating a cohesive role in mRNA maturation and ribosome recruitment.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":10},{"id":"GO:0002188","count":10},{"id":"GO:0045292","count":8},{"id":"GO:0006378","count":8},{"id":"GO:0048026","count":8}]},{"hash":"978994172961906209","title":"Embryonic organogenesis and vascular morphogenesis","description":"The terms are dominated by developmental processes: lung development, embryonic digestive tract development, and regulation of endothelial tube morphogenesis point to early organ and vascular formation. Supporting terms like cellular response to heat or response to toxic substance are peripheral stress responses, and BH4 biosynthesis or viral replication regulation are less central. Overall, a coherent theme is embryonic organ and vessel formation.","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006729","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0045071","count":2},{"id":"GO:0009636","count":2}]},{"hash":"41086952236802814","title":"Antiviral Defense and Autophagy Regulation","description":"This cluster strongly centers on host antiviral responses and intracellular quality control. GO terms include defense response to virus, autophagy, RIG-I signaling, and suppression of viral release, suggesting innate immune sensing and autophagic processing of viral components. Additional terms point to microtubule-associated transport and regulation of ubiquitin-dependent protein catabolism, which are linked to trafficking and protein turnover during infection. The inclusion of a term about positive regulation of viral entry likely reflects viral manipulation rather than host defense, but the dominant theme is antiviral signaling, autophagy, and intracellular transport control.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051607","count":4},{"id":"GO:0007026","count":4},{"id":"GO:1901253","count":3},{"id":"GO:0046598","count":3},{"id":"GO:2000059","count":3}]},{"hash":"1576416804368137971","title":"Actin Cytoskeleton Remodeling and Growth Signaling","description":"This cluster centers on actin cytoskeleton dynamics (filopodium and actin bundle assembly; barbed-end capping) and Rho signaling, coupled with insulin/IGF receptor pathways and ERK cascade regulation, pointing to a module of actin remodeling linked to growth and vascular signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0031532","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0048009","count":3}]},{"hash":"712591894170989625","title":"RNA splicing and translation initiation","description":"This cluster includes proteins linked to mRNA splicing via the spliceosome and to the assembly/regulation of the translation initiation complex, indicating a shared theme of RNA processing and initiation of translation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0045292","count":2},{"id":"GO:0034462","count":2},{"id":"GO:0006376","count":2}]},{"hash":"1711435826808192830","title":"RNA Splicing and Translation Initiation","description":"The cluster is enriched for spliceosome- and splicing-related processes (mRNA splicing, processome assembly, splice site recognition, alternative splicing) plus translation initiation complex formation (eIF4F assembly, preinitiation complex formation), indicating a group of proteins coordinating RNA processing and initiation of translation, with some links to mRNA stability and ncRNA regulation.","confidence":"High","size":22,"edges":229,"triangles":1501,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":16},{"id":"GO:0048026","count":13},{"id":"GO:0031047","count":13},{"id":"GO:0045292","count":12},{"id":"GO:0034462","count":12}]},{"hash":"1366366044420802817","title":"Unknown","description":"The GO terms are highly diverse (mitotic cell cycle, DNA damage response, GTPase regulation, visual perception, MAPK activation, cadmium response, calcium-dependent exocytosis, invasive growth, imprinting regulation, cell migration) with no clear shared function. There are no edges or interactions among the proteins (edges 0, triangles 0, max degree 0), which further suggests there is no cohesive biological theme tying them together. Unknown function cluster, no single representative process.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0006977","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007601","count":2},{"id":"GO:0000187","count":2}]},{"hash":"1217031328403431699","title":"Dopaminergic and retinal GPCR signaling","description":"The cluster\u2019s top GO terms point to GPCR-related processes (GPCR internalization, ERK signaling cascade), with strong links to dopaminergic synaptic transmission and vision-related signaling (opsin-mediated signaling) and retina development. This suggests a module centered on GPCR-driven signaling pathways that influence dopamine neurotransmission and retinal/vision biology, with related behavioral responses (e.g., to cocaine) reflecting dopaminergic regulation.","confidence":"Medium","size":22,"edges":214,"triangles":1234,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":22},{"id":"GO:0001963","count":21},{"id":"GO:0071380","count":21},{"id":"GO:0048148","count":21},{"id":"GO:0002031","count":21}]},{"hash":"1060442607641506380","title":"Dopaminergic signaling and cocaine-related neural responses","description":"The cluster\u2019s top GO terms cluster around neural signaling and reward-related processes: dopaminergic synaptic transmission, GPCR signaling with adenylate cyclase activation, and protein phosphorylation, alongside behavioral responses to cocaine and sensory perception of pain. This pattern strongly suggests a theme of dopamine-driven neuronal communication and drug-induced behaviors, with temperature-related terms likely reflecting broader neuroendocrine context. Overall, a coherent interpretation is dopamine-mediated neural signaling and cocaine-related behavioral responses.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0071380","count":11},{"id":"GO:0032720","count":10}]},{"hash":"2107720201107427135","title":"Ubiquitin-Mediated Protein Degradation and Immune Regulation","description":"Top GO terms are dominated by ubiquitination and proteolytic processes (protein ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination, K6-linked ubiquitination, ERAD), with histone catabolic process also represented, indicating broad protein turnover regulated by ubiquitin tagging. In addition, immune-related terms such as adaptive immune response and negative regulation of RIG-I signaling/viral material transport point to a role of ubiquitination in modulating immune signaling. Together these signals suggest a cohesive theme around ubiquitin-driven protein degradation pathways that intersect immune regulation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":16},{"id":"GO:0042787","count":16},{"id":"GO:0085020","count":15},{"id":"GO:1903265","count":15},{"id":"GO:0036205","count":15}]},{"hash":"1318863732211340095","title":"Innate immune and apoptotic regulation","description":"The top GO terms are dominated by innate immune and apoptotic processes: cellular response to lipopolysaccharide, regulation of Fc receptor signaling, and phosphatidylserine exposure on apoptotic cells, with additional links to autophagy and transcriptional regulation. While there are some metabolic terms (cholesterol and glucose homeostasis) and placenta development, the strongest consistent theme across terms points to immune signaling and apoptotic/clearance pathways, making this a coherent cluster for innate immune and apoptotic regulation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:1903147","count":2},{"id":"GO:0070782","count":2},{"id":"GO:0001300","count":2},{"id":"GO:2000373","count":2}]},{"hash":"1801848243602423898","title":"Ubiquitin-Dependent Regulation of Signaling and Apoptosis","description":"The cluster is dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, protein autoubiquitination, and specific ubiquitin linkages, indicating regulation of protein degradation. Additional GO terms point to NF-\u03baB pathway control (I-kappaB phosphorylation), TNF signaling, and chromatin dynamics (histone catabolic process), all coherent within ubiquitin-mediated regulation of signaling and cell fate. Some terms (V(D)J recombination, dosage compensation) are related but can intersect with ubiquitin-mediated chromatin and immune processes, reinforcing the central theme of ubiquitin-dependent control of cellular signaling and apoptosis.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0051865","count":10},{"id":"GO:1901253","count":9},{"id":"GO:0033151","count":9},{"id":"GO:0085020","count":9}]},{"hash":"2275796138989333531","title":"Polyamine biosynthesis and transport","description":"This cluster is dominated by GO terms related to polyamine production and handling: arginine catabolism toward ornithine, putrescine and spermidine biosynthesis, and positive regulation of polyamine transport. While a few unrelated terms are present (kidney development, Golgi organization, antibiotic biosynthesis, oxidative detoxification), the strongest repeated theme centers on polyamine metabolism and movement, making this label representative of the cluster\u2019s core function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006527","count":5},{"id":"GO:0009089","count":5},{"id":"GO:0098629","count":5},{"id":"GO:0033387","count":5},{"id":"GO:1902269","count":5}]},{"hash":"1546084503005454634","title":"RNA Processing and Ribosome Biogenesis","description":"The top GO terms cluster around RNA metabolism (transcription antitermination, mRNA capping, alternative splicing regulation) and ribosome biogenesis, suggesting a core role in RNA processing and ribosome assembly. Some terms also hint at neuronal localization and development, likely reflecting multifunctional proteins in the set; however the strongest signal is RNA processing and ribosome biogenesis.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031564","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0002175","count":2}]},{"hash":"2214321475577363315","title":"Neural development and axon guidance","description":"The top terms cluster around nervous system development, especially axon guidance, fasciculation, and regeneration (motor neuron axon guidance; axonal fasciculation; axon extension in regeneration; mechanoreceptor differentiation). While there are some immune and heart-related terms, the strongest and most coherent signal is neural development and axon wiring.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0042490","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1156439254522539331","title":"Neuronal signaling and taste perception","description":"Dominant terms describe neural communication and sensory-related behaviors: locomotory behavior, conditioned taste aversion, gamma-aminobutyric acid signaling, regulation of glutamatergic synaptic transmission, and detection of sweet taste. These indicate a functional cluster centered on neurotransmission and taste processing. A few terms about peptidoglycan/cell wall catabolism and viral release appear less related and are likely incidental annotations rather than core functions.","confidence":"High","size":22,"edges":192,"triangles":917,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":20},{"id":"GO:0001661","count":20},{"id":"GO:0007214","count":20},{"id":"GO:0009253","count":13},{"id":"GO:0051966","count":13}]},{"hash":"1768615835129895387","title":"Neuronal ion channels and auditory signaling","description":"This cluster centers on neural excitability and signal transduction, with GO terms for sodium/potassium ion transport, membrane depolarization, and synaptic activity (excitatory postsynaptic potential, GABA signaling) plus sensory/perception of sound, pointing to neuronal ion-channel-mediated signaling and auditory processing. A stray immune-related term appears unrelated noise. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035725","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0060079","count":9},{"id":"GO:0007626","count":7},{"id":"GO:0001661","count":7}]},{"hash":"582116681534775928","title":"Embryonic tissue and organ development","description":"The GO terms point to diverse developmental processes across tissues (lens morphogenesis/differentiation, palate/roof of mouth development, pancreatic cell development, trophoblast differentiation, axis specification, and visual perception), with additional general regulatory roles like transcriptional control and proteolysis. This suggests a broad theme of embryonic organogenesis and tissue differentiation rather than a single pathway, despite the lack of strong connectivity among proteins. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0060021","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0007313","count":4}]},{"hash":"2167910692851617181","title":"Taste Perception and Neural Synaptic Signaling","description":"These proteins cluster around sensory processing and synaptic signaling in the nervous system: strong representation of GO terms for taste perception (sweet), conditioned taste aversion, locomotory behavior, and GPCR-mediated signaling; along with ion transport and excitatory postsynaptic potential, supporting synaptic transmission via glutamate and GABA pathways. The combination suggests a functional module centered on taste-related neural signaling and sensory integration.","confidence":"High","size":22,"edges":126,"triangles":294,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":22},{"id":"GO:0001661","count":22},{"id":"GO:0007214","count":22},{"id":"GO:0035725","count":20},{"id":"GO:0071805","count":20}]},{"hash":"385209029345399066","title":"Neural crest migration and axon guidance","description":"GO terms such as axonal fasciculation, neuron projection guidance, neural crest migration, and semaphorin-plexin signaling point to neural development and axon pathfinding as the dominant theme of this cluster. While a bone ossification term appears among the top terms, the overall signal is strongly connected to neural wiring and neural crest\u2013derived processes, supporting a focus on axon guidance and neural development.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":10},{"id":"GO:0014068","count":10},{"id":"GO:0021637","count":9},{"id":"GO:0097490","count":9},{"id":"GO:0021785","count":9}]},{"hash":"799234715343213397","title":"Neural development and cytoskeleton organization","description":"The cluster\u2019s top GO terms are dominated by nervous system development and cytoskeletal processes, including astrocyte development, PNS neuron axonogenesis, axonal transport of mitochondrion, neurofilament bundle assembly, and establishment of microtubule cytoskeleton polarity. While there are some outliers (cornification, hepatocyte apoptosis, cardiac muscle development, skin barrier), the neural development and cytoskeleton-focused terms most strongly tie the proteins together, suggesting a group enriched for neurite/axonal maintenance and cytoskeletal organization.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":5},{"id":"GO:0019896","count":4},{"id":"GO:0070268","count":4},{"id":"GO:0030951","count":4},{"id":"GO:0055015","count":4}]},{"hash":"1736835083684448745","title":"Neuronal development and axonogenesis cluster","description":"Contains multiple GO terms focused on nervous system development and axon-related processes (astrocyte development, PNS neuron axonogenesis, neurofilament assembly, and axonal transport of mitochondria; plus microtubule polarity), indicating a cohesive theme around neuron formation and axon structure. A few terms refer to unrelated tissues, but they do not outweigh the neuronal signal.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0019896","count":3},{"id":"GO:0070268","count":3}]},{"hash":"1378207712627508983","title":"Ubiquitin-Dependent Degradation and Antiviral Immunity","description":"The cluster is dominated by ubiquitin-related processes (ubiquitination, ubiquitin-dependent protein catabolic process) and autophagy, with supporting roles in ERAD and histone turnover. Additional terms point to immune modulation (adaptive immune response, negative regulation of RIG-I signaling), linking protein quality control to antiviral signaling. This suggests a cohesive theme of protein turnover intersecting with innate/adaptive immune regulation, possibly including vitamin D\u2013related responses.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:0016567","count":15},{"id":"GO:0033280","count":13},{"id":"GO:0051865","count":12},{"id":"GO:0036205","count":12}]},{"hash":"1786043301525775801","title":"Oogenesis and Neural Development via Ubiquitin-Proteasome Regulation","description":"This cluster centers on oocyte maturation and neural development, as indicated by GO terms for oocyte maturation, spindle assembly in female meiosis I, and initiation of neural tube closure. The strongest signals are ubiquitin-dependent proteolysis pathways (SCF and proteasomal degradation) and related protein catabolic processes, suggesting coordinated protein turnover and regulation of transcription/epigenetics during meiotic progression and neural development. Overall, these proteins likely function in developmental regulation through proteostasis and cell-cycle control.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021678","count":11},{"id":"GO:0042787","count":11},{"id":"GO:0031146","count":10},{"id":"GO:0006516","count":8},{"id":"GO:0008285","count":8}]},{"hash":"1458788147894656401","title":"Transmembrane Ion and Sugar Transporters","description":"Reasoning: The top GO terms are dominated by transmembrane transport across membranes for ions (potassium, sodium, phosphate), sugars (galactose, arabinose), and xenobiotics, plus a vesicular transport term (neurotransmitter loading). This suggests a cohesive cluster of membrane transport proteins/transporters, with a peripheral developmental term likely incidental.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0072221","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0042891","count":2}]},{"hash":"1311188337718551617","title":"Unknown","description":"The cluster combines lipid metabolism, fertilization, phagolysosome formation, fibrinolysis, and various cell-cycle and differentiation processes with no clear, cohesive functional theme, and it has no observed edges, suggesting it does not form a single modular function.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051006","count":5},{"id":"GO:0007338","count":4},{"id":"GO:0001845","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0000278","count":3}]},{"hash":"1471222251638641498","title":"Embryonic Development and Morphogenesis","description":"Dominant GO terms describe embryonic development and morphogenesis (placental differentiation, EMT in heart cushion formation, cartilage and hair follicle morphogenesis, left-right patterning, endocrine system development). This indicates a shared role in embryogenesis and organ/tissue morphogenesis rather than a single metabolic pathway. Some terms (ribosomal export, DNA replication initiation) are more general but do not outweigh the developmental theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":22},{"id":"GO:0003198","count":22},{"id":"GO:0060806","count":22},{"id":"GO:0003323","count":22},{"id":"GO:0035270","count":22}]},{"hash":"2229732506174066824","title":"Unknown","description":"The top GO terms span innate immunity, host-symbiont interaction, stem cell maintenance, sensory perception, muscle development, mitochondrial membrane dynamics, chromatin assembly, and oxidative stress responses. This broad, non-overlapping mix shows no single cohesive function tying the proteins together, and the network has no edges, suggesting heterogeneous or unrelated roles rather than a single pathway. ","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0046597","count":2},{"id":"GO:0019827","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0048741","count":2}]},{"hash":"1961940135762566124","title":"Embryonic development and organ morphogenesis","description":"The top GO terms point to a broad set of embryonic processes\u2014trophoblast differentiation, epithelial-to-mesenchymal transition in heart development, placenta formation, endocrine organ development, and various morphogenetic events (cartilage, hair follicles, facial structures, left-right patterning). This indicates a general embryogenesis/morphogenesis theme rather than a single specific function, justifying a label around embryonic development and organ formation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003323","count":8}]},{"hash":"62616390059722985","title":"Developmental Morphogenesis and Signaling","description":"The top GO terms cluster around morphogenesis across multiple tissues (dendrite, outer ear, mammary gland) and incorporate signaling responses (prostaglandin E, phorbol ester) and regulation of leukocyte chemotaxis, with supportive processes like sterol import and DNA repair. This suggests a cohesive theme centered on developmental morphogenesis linked with cellular signaling pathways, rather than disparate functions.","confidence":"Medium","size":21,"edges":155,"triangles":561,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":21},{"id":"GO:1990804","count":21},{"id":"GO:0033598","count":21},{"id":"GO:0002688","count":21},{"id":"GO:0071380","count":21}]},{"hash":"1706460075654819165","title":"Proteoglycan biosynthesis and hormone metabolism","description":"The top GO terms cluster around glycosaminoglycan biosynthesis (keratan sulfate, dermatan sulfate, heparin proteoglycans) and related sugar metabolism, with several hormone-related metabolic processes (thyroid hormone metabolism, estrogen catabolic process, regulation of angiotensin). This suggests a theme linking extracellular matrix proteoglycan synthesis to broader endocrine/metabolic functions, with embryonic neurocranium morphogenesis indicating developmental ECM involvement. Overall, proteoglycan biosynthesis combined with hormone and related metabolic processes best captures the cluster.","confidence":"Medium","size":21,"edges":39,"triangles":6,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0002002","count":6},{"id":"GO:0006711","count":6},{"id":"GO:0018146","count":6},{"id":"GO:0006044","count":6},{"id":"GO:0030205","count":6}]},{"hash":"686456883767873839","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":203,"triangles":1213,"max_degree":20,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":14},{"id":"GO:0031047","count":14},{"id":"GO:1903608","count":11},{"id":"GO:0000398","count":9},{"id":"GO:1901407","count":9}]},{"hash":"396344433904550365","title":"Unknown","description":"The top GO terms cover very different processes: DNA replication and base-excision repair (nuclear), vesicle docking in exocytosis (secretory pathway), and extracellular matrix-related biosynthesis and barrier formation, as well as infection structure formation. There is no single unifying function or pathway linking most proteins in this cluster, so a concise, meaningful label is not supported.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006486","count":4},{"id":"GO:0019276","count":3},{"id":"GO:0030279","count":3},{"id":"GO:0050650","count":3},{"id":"GO:0075015","count":3}]},{"hash":"718396559616830964","title":"Protein acetylation and amino-sugar metabolism","description":"The cluster is dominated by acetylation-related terms, including peptidyl-lysine N6-acetylation and N-terminal peptidyl-methionine acetylation, along with related metabolic steps such as glucosamine/N-acetylglucosamine metabolism and putrescine acetylation/catabolism; a couple of outliers (angiogenesis, subtelomeric heterochromatin formation) are present but minor.","confidence":"Medium","size":21,"edges":52,"triangles":34,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0018003","count":9},{"id":"GO:0006348","count":9},{"id":"GO:0001525","count":8},{"id":"GO:0019491","count":8},{"id":"GO:0017196","count":8}]},{"hash":"156261107964836898","title":"EMT and Integrin Signaling in Development","description":"The top GO terms cluster around epithelial-to-mesenchymal transition (EMT), cellular response to TGF-\u03b2, and integrin-mediated signaling/activation, with supporting terms on cell adhesion and signal complex assembly. Although some terms point to neural development, the central theme is EMT/tGF-\u03b2\u2013driven integrin signaling and adhesion in development.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0001837","count":6},{"id":"GO:0071560","count":5},{"id":"GO:0007229","count":4},{"id":"GO:0021744","count":4},{"id":"GO:0042976","count":4}]},{"hash":"457381840797147132","title":"Developmental Differentiation and Cell-cycle Regulation","description":"The top GO terms point to multicellular development (neuron projection development, lens fiber cell differentiation, skeletal system development) alongside mitotic processes (mitotic spindle assembly, mitotic cell cycle) and transcription, with regulatory cues like negative regulation of protein kinase activity and ubiquitination. This suggests a cluster of proteins coordinating developmental differentiation with cell-cycle control and transcriptional regulation, rather than a single narrow function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0071901","count":5},{"id":"GO:0031175","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0070306","count":4}]},{"hash":"771964868999426012","title":"Ubiquitin-like Modifications and Autophagy","description":"The cluster is enriched in GO terms related to ubiquitin-like protein modification systems (ubiquitination, deubiquitination, sumoylation, neddylation, urmylation) and autophagy (macroautophagy and piecemeal microautophagy of the nucleus). This suggests proteins here participate in tagging proteins for turnover and engaging autophagic pathways, linking post-translational modifications to degradation processes. While thiamine biosynthesis terms appear, the dominant signal is PTMs and autophagy. ","confidence":"High","size":21,"edges":151,"triangles":625,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0016925","count":10},{"id":"GO:0016579","count":6},{"id":"GO:0016567","count":5},{"id":"GO:0009228","count":5},{"id":"GO:0061504","count":5}]},{"hash":"449429751806800330","title":"Muscle and heart development","description":"This cluster is driven by terms tied to muscle formation (myoblast fate determination, myoblast fusion, branchiomeric skeletal muscle development) and cardiac development (sinoatrial node differentiation, heart-related transcription regulation). The strong presence of muscle and heart\u2013related processes suggests a shared developmental program for muscle and cardiac lineage specification, with a few outliers likely representing broader developmental regulation or annotation noise.","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0060921","count":21},{"id":"GO:0010374","count":21},{"id":"GO:0035481","count":21},{"id":"GO:2000763","count":21},{"id":"GO:0060485","count":21}]},{"hash":"1465507599576007350","title":"Neuronal signaling and sensory perception","description":"This cluster is dominated by GO terms related to sensory and neural processes\u2014visual perception, visual learning, pain perception, and dopaminergic synaptic transmission\u2014as well as behavioral responses to cocaine and signaling pathways like ERK activation and membrane potential regulation. Together these indicate a cohesive theme of neuronal signaling, sensory processing, and drug-induced behavioral modulation, despite a couple of terms (e.g., heart development, macrophage chemotaxis) that reflect broader signaling contexts.","confidence":"High","size":21,"edges":95,"triangles":69,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0008542","count":19},{"id":"GO:0071380","count":18},{"id":"GO:0070374","count":18}]},{"hash":"521082367254120927","title":"Angiogenesis and vascular remodeling signaling","description":"The top terms cluster around angiogenesis, endothelial and smooth muscle cell migration, and growth factor\u2013driven signaling pathways (ERK, tyrosine phosphorylation, PI3K), with additional signals related to immune response and insulin stimulus, suggesting a vascular development/remodeling signaling theme that also intersects immune context.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070374","count":10},{"id":"GO:0043536","count":8},{"id":"GO:0001525","count":8},{"id":"GO:0038063","count":8},{"id":"GO:0002250","count":8}]},{"hash":"1965349031990286421","title":"ERAD and Proteasome-Driven Proteostasis","description":"This cluster is dominated by ubiquitin-proteasome system activities, especially ubiquitin-dependent ERAD, and regulation of deubiquitination and proteasome-mediated protein degradation. Additional terms touching Golgi organization, lipid droplet organization, and cell death suggest a broader link to intracellular protein quality control and turnover. The common theme tying these terms together is proteostasis maintained by ERAD and the ubiquitin\u2013proteasome system.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:1903094","count":5},{"id":"GO:2000157","count":5},{"id":"GO:0007030","count":5},{"id":"GO:0031134","count":4}]},{"hash":"108638549484118220","title":"Inflammation, coagulation, and tissue remodeling","description":"This cluster centers on immune activation and vascular/tissue changes: responses to LPS, production of IL-1\u03b2 and fractalkine, acute-phase signaling, and coordinated regulation of coagulation, fibrinolysis, and tissue remodeling/angiogenesis. While a transcriptional regulation term and digestion appear, the dominant theme ties inflammatory signaling to coagulation and tissue remodeling, suggesting proteins that function in inflammatory responses with vascular remodeling implications.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0032496","count":7},{"id":"GO:0042730","count":6},{"id":"GO:0050720","count":6},{"id":"GO:0050754","count":6}]},{"hash":"2125427671329666184","title":"Neural development and synaptic adhesion","description":"The top GO terms point to neural and sensory organ development (inner ear, brain, neuroepithelial differentiation, R8 photoreceptor cell) and synaptic organization (PSD-95 clustering) with broad cell-cell adhesion (heterophilic adhesion). A few terms relate to other tissues (ureter maturation, Purkinje/ bundle of His), but the dominant signal is neural/sensory development and adhesion, fitting a cluster centered on neural differentiation and synaptic connectivity.","confidence":"Medium","size":21,"edges":26,"triangles":0,"max_degree":10,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0048839","count":9},{"id":"GO:0007420","count":9},{"id":"GO:0043568","count":8},{"id":"GO:0060563","count":8},{"id":"GO:0035799","count":8}]},{"hash":"1860419294481567857","title":"Plant cell wall biosynthesis","description":"This cluster is strongly enriched for plant-specific cell wall processes, including glucuronoxylan biosynthesis, plant-type secondary cell wall biogenesis, and cell wall organization, indicating a core role in synthesizing and organizing plant cell wall polysaccharides. Additional carbohydrate metabolism terms (starch and sucrose biosynthesis) support a broader plant carbohydrate metabolism connection, though a few terms related to DNA repair or AMP salvage may be less related background noise.","confidence":"High","size":21,"edges":188,"triangles":990,"max_degree":20,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0005978","count":6},{"id":"GO:0071555","count":6},{"id":"GO:0010417","count":6},{"id":"GO:0009834","count":6},{"id":"GO:0006310","count":5}]},{"hash":"580489199368013883","title":"Eye development and visual system morphogenesis","description":"This cluster is dominated by GO terms related to eye development and vision (camera-type eye development, visual perception), with embryonic eye morphogenesis and eye morphogenesis heavily represented. While there are additional terms for neural and musculoskeletal development, the strongest signal is eye/visual system morphogenesis.","confidence":"High","size":21,"edges":14,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043010","count":13},{"id":"GO:0000122","count":11},{"id":"GO:0006366","count":11},{"id":"GO:0008045","count":10},{"id":"GO:0060441","count":10}]},{"hash":"1028113002075297774","title":"Cardiovascular vasculature development and coagulation","description":"This cluster is strongly enriched for terms related to blood coagulation, endothelial cell movement, smooth muscle proliferation/migration, and vascular/heart development (sprouting angiogenesis, coronary vasculature, atrial septum morphogenesis), pointing to a cohesive theme of cardiovascular vasculature formation and remodeling, with coagulation integration.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:2001027","count":6},{"id":"GO:0048661","count":6},{"id":"GO:0001501","count":6},{"id":"GO:0014909","count":6}]},{"hash":"2100491831108979304","title":"ERK signaling and secretory trafficking in development","description":"The cluster shows enrichment for positive regulation of the ERK1/2 cascade, plus several vesicle trafficking terms between the ER, Golgi, and plasma membrane, along with development-related morphogenesis terms (hair follicle morphogenesis, ossification, gland formation). This suggests a theme where signaling via ERK intersects with intracellular transport processes to drive developmental morphology, hence a label centered on developmental signaling and secretory transport.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0031069","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0006893","count":4},{"id":"GO:0000055","count":3}]},{"hash":"337406067603472877","title":"Developmental Signaling and Morphogenesis","description":"This cluster centers on GO terms tied to tissue development across multiple organs (bone, heart, mammary branching morphogenesis, axonogenesis) and key signaling pathways (Rho, Wnt, integrin signaling). While there are also innate immune and apoptotic terms, the prevailing pattern is participation in signaling networks that drive development and morphogenesis, so a development/signaling-focused label is most representative.","confidence":"Medium","size":21,"edges":20,"triangles":0,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0060444","count":3}]},{"hash":"1000538609569344773","title":"Neural development and axon guidance","description":"The cluster is strongly enriched for terms related to nervous system development, nerve structure and organization (paranode localization, trigeminal nerve organization), and axon guidance, with supporting links to cytoskeletal signaling (Rho) and cellular responses to mechanical stimuli. Immune-related terms (defense to virus, B cell receptor signaling) are present but less central, so the dominant theme is neural development and axon guidance.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045214","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0002175","count":3}]},{"hash":"42139430064894411","title":"Chromatin Remodeling and Transcription Initiation","description":"This cluster is enriched for GO terms tied to chromatin dynamics and transcription control, including transcription initiation-coupled chromatin remodeling, DNA-templated transcription initiation, and DNA replication-dependent chromatin assembly, as well as heterochromatin formation and histone modifications. The presence of negative regulation of transcription by RNA Pol II and protein heterotetramerization supports assembly and regulation of transcription-related complexes centered on chromatin state.","confidence":"High","size":21,"edges":204,"triangles":1222,"max_degree":20,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0051290","count":13},{"id":"GO:0000122","count":11},{"id":"GO:0045815","count":8},{"id":"GO:0000183","count":8},{"id":"GO:0006335","count":8}]},{"hash":"2222936691171134470","title":"Cytoskeletal remodeling and cell motility","description":"The GO terms cluster around actin-driven protrusions (filopodium and lamellipodium assembly), cell spreading and adhesion, and regulation of Rho signaling, all core to cytoskeletal remodeling and cell movement. Immune and vascular processes referenced (B cell maturation, neutrophil activity, vessel remodeling, dendritic spine dynamics) are contexts where these motility and shape-change mechanisms are essential, supporting a cohesive theme of actin-driven motility and remodeling across diverse cell types.","confidence":"High","size":21,"edges":26,"triangles":7,"max_degree":15,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0010765","count":14},{"id":"GO:0046847","count":13},{"id":"GO:0002344","count":12},{"id":"GO:1903526","count":12},{"id":"GO:0035023","count":11}]},{"hash":"2130208029328293938","title":"Neuronal signaling and endosomal trafficking","description":"The terms cluster around neural signaling and nerve structure (neurotrophin TRK receptor signaling, olfactory nerve organization) alongside vesicular trafficking processes (endosome organization, endosome-to-lysosome transport). There are also muscle-innervation and calcium-regulated contraction terms, suggesting a neuromuscular context where endosomal signaling interfaces with muscle response. Overall, the cluster seems to represent neural signaling with associated endosomal trafficking, with some muscle-related connections.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007032","count":4},{"id":"GO:0043552","count":3},{"id":"GO:0008333","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0016203","count":3}]},{"hash":"1259375582134791895","title":"GPCR-cAMP Signaling and Thermogenesis","description":"Top GO terms cluster around GPCR signaling that activates adenylate cyclase and phospholipase C (e.g., dopamine receptor signaling), with concurrent indicators of energy metabolism (electron transport chain) and thermogenic/sensory responses (diet-induced thermogenesis, cellular response to temperature, phototransduction). This suggests a compact functional theme of GPCR-driven signaling linked to metabolic regulation and temperature/sensory processes.","confidence":"Medium","size":21,"edges":10,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0045777","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10}]},{"hash":"1757240371442331405","title":"RNA processing and translation initiation","description":"This cluster is dominated by RNA-related activities: mRNA capping, RNA guanine-N7 methylation, rRNA maturation, and formation of the translation preinitiation complex, indicating a core theme of RNA processing and initiation of translation. A few linked terms (mitosis, neural tube closure, endosome transport) are less central, likely reflecting broader multifunctional proteins in the set. Overall, the RNA processing/translation initiation signal is the strongest, justifying the label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:0018026","count":3},{"id":"GO:0006370","count":3},{"id":"GO:0034499","count":2},{"id":"GO:0043984","count":2}]},{"hash":"1018148823256352766","title":"Proteoglycan/ECM biosynthesis in development","description":"The cluster is enriched for proteoglycan biosynthetic processes (chondroitin sulfate, dermatan sulfate) and glycosaminoglycan synthesis (poly-N-acetyllactosamine), indicating extracellular matrix assembly. The terms also point to epithelial polarity and cell adhesion in developmental contexts (follicle epithelium, insect visual primordium), suggesting ECM production guides tissue organization; some plant-related mucilage and seed coat terms appear, but the dominant signal is proteoglycan/ECM biosynthesis linked to development.","confidence":"Medium","size":21,"edges":70,"triangles":65,"max_degree":12,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0005975","count":3},{"id":"GO:0006278","count":3},{"id":"GO:0050650","count":3},{"id":"GO:0050651","count":3}]},{"hash":"910267931845763304","title":"Developmental signaling and tissue remodeling","description":"The cluster's terms cluster around developmental signaling and tissue remodeling: Wnt signaling, multicellular development, neuron projection development, wound healing, and proteolysis. Additional hints from positive regulation of cell growth and hypoxia response suggest adaptive development and remodeling in tissues, including neural components and inflammatory contexts such as neutrophil extravasation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007253","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0048549","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1112581098873922087","title":"Taste perception and GABAergic signaling","description":"The cluster is dominated by GO terms linking taste perception (sweet taste detection), GABA signaling, and related neuronal signaling pathways, along with locomotion and aversion behavior, suggesting a cohesive theme of taste-related neural signaling and movement rather than unrelated processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0007626","count":21},{"id":"GO:0001661","count":21},{"id":"GO:0007214","count":21},{"id":"GO:0001582","count":20},{"id":"GO:0000187","count":20}]},{"hash":"120959862385710367","title":"Glutamatergic Synaptic Transmission and Ion Transport","description":"The cluster is dominated by terms related to neuronal signaling: sodium and potassium ion transmembrane transport, excitatory postsynaptic potentials, and regulation of glutamatergic synaptic transmission, along with sensory perception of sound, indicating a coherent module of neuronal excitability and synaptic communication. Some non-neuronal terms (peptidoglycan metabolism, fungicide response, viral release) may reflect annotation noise but do not override the neural theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0007605","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0009253","count":4}]},{"hash":"1831728708979850289","title":"Transcription, Translation Initiation, and Ubiquitination in Development","description":"The top terms cluster around initiation of translation and transcription, RNA processing marks, and ubiquitin-mediated regulation, with developmental processes highlighted by several GO terms. This suggests a group of proteins that jointly regulate gene expression at transcriptional and translational levels and are involved in development, potentially via ubiquitin-dependent control and RNA processing steps.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001731","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0000209","count":5},{"id":"GO:0007018","count":5}]},{"hash":"1238252681094349522","title":"Mitochondria-centered apoptosis regulation","description":"The cluster is dominated by terms linked to apoptosis control, including both intrinsic and extrinsic pathways, cytochrome c release, and mitochondrial depolarization, pointing to mitochondria-driven regulation of cell death. Additional terms reference membrane potential maintenance and related stress responses, consistent with mitochondrial quality control and associated autophagic processes. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043154","count":3},{"id":"GO:0061042","count":3},{"id":"GO:0035461","count":2},{"id":"GO:2001240","count":2},{"id":"GO:0051902","count":2}]},{"hash":"2003042804349382875","title":"Neuroendocrine Cardiovascular Signaling","description":"The cluster is dominated by GO terms for GPCR signaling with cGMP, ERK1/2 cascade, and dopaminergic synaptic transmission, plus heart development and renin regulation, which together point to neural/endocrine control of cardiovascular function. Additional terms cover metabolism/thermogenesis and feeding behavior, with some immune-related terms (defense to bacteria, coagulation) that may reflect shared signaling components. Taken together, the data suggest a theme of signaling networks coordinating neuroendocrine and cardiovascular physiology.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042742","count":14},{"id":"GO:0007596","count":14},{"id":"GO:0070374","count":14},{"id":"GO:0007507","count":14},{"id":"GO:0046960","count":13}]},{"hash":"2023276048138305865","title":"Embryonic and Placental Morphogenesis","description":"Most top GO terms cluster around development and tissue morphogenesis, including trophoblast giant cell differentiation, EMT in heart/endocardial cushion formation, placenta development, endocrine system development, cartilage morphogenesis, hair follicle morphogenesis, and left-right pattern formation. This suggests a cohesive theme of embryogenesis and organ/tissue morphogenesis, with a couple of peripheral terms related to ribosome export and DNA replication that don\u2019t override the central developmental signal.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":19},{"id":"GO:0003198","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0003323","count":19},{"id":"GO:0035270","count":19}]},{"hash":"2152387594823496572","title":"Ubiquitin-regulated plant circadian and tropic responses","description":"This cluster is dominated by ubiquitin-dependent protein catabolic processes and circadian rhythm regulation, with plant-specific growth responses such as phototropism and gravitropism, suggesting a theme of ubiquitin-mediated control of circadian and tropic growth. Some terms appear more general, but the strongest signal is plant circadian/tropic regulation via ubiquitination.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0042752","count":11},{"id":"GO:0051260","count":10},{"id":"GO:1900242","count":8},{"id":"GO:1990390","count":8}]},{"hash":"391977148661860647","title":"Inflammatory signaling and lipid metabolism regulation","description":"This set centers on inflammatory signaling pathways and lipid-mediated regulation. Frequent terms include inflammatory response, TNF signaling, and NF-kappaB regulation, plus thrombin receptor signaling and angiogenesis, indicating growth and vascular responses during inflammation. Additionally, lipid metabolism-related terms (endocannabinoid signaling, triglyceride and sphingoid catabolism) suggest regulation of inflammatory signaling by lipid mediators.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:2000124","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0006954","count":5}]},{"hash":"1615319886603682906","title":"Mitochondrial and Synaptic Vesicle Regulation","description":"The top GO terms cluster around mitochondrial structure and ion homeostasis (cristae formation, mitochondrial calcium homeostasis) and synaptic processes (neurotransmitter loading into vesicles, SNARE complex regulation, ion transport). This suggests a shared theme of mitochondria-related regulation of synaptic transmission and ion balance, despite some noise in terms. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0009409","count":2},{"id":"GO:0051290","count":2},{"id":"GO:0051560","count":2},{"id":"GO:0099132","count":2}]},{"hash":"48073296616980409","title":"Axon development, synapse assembly, and myelination","description":"This cluster is dominated by GO terms related to neural development and connectivity: transmission of nerve impulse, axonal fasciculation, myelination, and positive regulation of synapse assembly, along with cell adhesion, all pointing to axon formation, nerve signaling, and synaptic/network maturation. A few outliers (obsolete PI3K regulation terms, symbiont entry into host cell, skeletal development) may reflect annotation noise or broader roles, but the core theme clearly centers on neural development and myelination.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0019226","count":6},{"id":"GO:0043552","count":5},{"id":"GO:0045663","count":5},{"id":"GO:0007413","count":5},{"id":"GO:0042552","count":5}]},{"hash":"491251061382094412","title":"Embryonic Development and Morphogenesis","description":"The top GO terms point to broad developmental and morphogenetic processes across tissues, including placental differentiation, heart-associated EMT, endocrine organ development, and organogenesis (cartilage, hair follicle, palate, left-right patterning). This suggests the cluster comprises proteins involved in embryonic tissue formation and organ morphogenesis rather than a single pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0060707","count":21},{"id":"GO:0003198","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0035270","count":21},{"id":"GO:0003323","count":21}]},{"hash":"1273597777996513572","title":"Neural development and GTPase signaling","description":"The cluster shows predominance of nervous system development and GTPase signaling terms (e.g., sympathetic nervous system development; positive regulation of neuron migration; regulation of GTPase activity; Rac signaling; light perception). While some entries are less related (e.g., hepatocyte apoptotic process), the core theme appears to be neural differentiation and cytoskeletal signaling mediated by GTPases.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090597","count":2},{"id":"GO:0048485","count":2},{"id":"GO:0050908","count":2},{"id":"GO:0043087","count":2},{"id":"GO:2001224","count":2}]},{"hash":"1663824413543690634","title":"Reproductive steroid hormone metabolism and parturition","description":"This cluster is dominated by GO terms related to steroid hormone metabolism (androgen metabolic process, cholesterol catabolic process, vitamin D-related responses) and reproductive development (sex differentiation, female genitalia development) as well as labor-related signaling (prostaglandin biosynthetic process, maternal process involved in parturition). Together these terms suggest a cohesive theme of reproductive hormone metabolism linked to parturition cues, with some additional ion-response terms that may reflect broader cellular contexts. Confidence: High","confidence":"","size":20,"edges":173,"triangles":874,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":13},{"id":"GO:0060137","count":12},{"id":"GO:0010164","count":12},{"id":"GO:0030540","count":12},{"id":"GO:0042369","count":12}]},{"hash":"1002254426425064699","title":"Unknown","description":"The top GO terms in this cluster cover unrelated biological themes, including bacterial lipopolysaccharide biosynthesis, hematopoietic progenitor differentiation, hormone response, lipid/phospholipid modifications, stilbene catabolism, epoxygenase P450 activity, and metal ion transport with calcium homeostasis. There is no single cohesive function that ties these terms together, so a specific, meaningful label cannot be inferred.","confidence":"","size":20,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":5},{"id":"GO:0002244","count":5},{"id":"GO:0033574","count":4},{"id":"GO:0046839","count":4},{"id":"GO:0046272","count":4}]},{"hash":"1978578027333889347","title":"Embryonic organogenesis and tissue morphogenesis","description":"The most frequent GO terms describe development and morphogenesis across diverse tissues (eye, hindlimb, heart outflow tract, glands, cartilage). While some metabolic and signaling terms appear, the shared theme is embryonic tissue formation and organ development, suggesting this cluster represents genes involved in developmental processes rather than a single pathway.","confidence":"Medium","size":20,"edges":32,"triangles":0,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070858","count":4},{"id":"GO:0003148","count":4},{"id":"GO:0046321","count":4},{"id":"GO:0060591","count":4},{"id":"GO:0060749","count":4}]},{"hash":"2032106161754468300","title":"Mitochondrial Translation and Respiration","description":"The dominant GO terms point to mitochondrial energy generation and gene expression: electron transport and ATP synthesis (mitochondrial oxidative phosphorylation) alongside translation and maturation of LSU-rRNA, plus rRNA base methylation and translation regulation, which together suggest mitochondrial ribosomes and their function. Some terms like antibiotic biosynthetic process and photosynthesis may reflect bacterial ancestry or broad annotations, but the core cluster theme is mitochondrial energy production coupled with mitochondrial protein synthesis. Confidence: High","confidence":"","size":20,"edges":180,"triangles":973,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":3},{"id":"GO:0042773","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0070475","count":1}]},{"hash":"1731399213299309081","title":"Embryonic morphogenesis and developmental signaling","description":"This cluster is dominated by terms tied to embryogenesis and morphogenesis (neural plate development, embryonic body morphogenesis, root development), along with processes like cell migration, regulation of Wnt signaling, and apoptotic control, all indicating coordinated developmental signaling and tissue remodeling; a few outlier terms (e.g., plant cell wall biogenesis) do not alter the main theme.","confidence":"High","size":20,"edges":49,"triangles":25,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048364","count":9},{"id":"GO:0015991","count":8},{"id":"GO:0043065","count":7},{"id":"GO:0090090","count":7},{"id":"GO:0016477","count":7}]},{"hash":"1103278002780166829","title":"Neural development and synaptic signaling","description":"Dominant GO terms center on nervous system and brain development, plus regulation of synaptic vesicle exocytosis and phosphatidylinositol signaling, indicating proteins involved in neural development and synaptic transmission. Secondary terms like angiogenesis, neuron survival, and ribophagy may reflect supporting aspects of neural-vascular interactions and cellular homeostasis, but the core theme is neural development and synaptic communication.","confidence":"High","size":20,"edges":185,"triangles":1056,"max_degree":19,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0048015","count":5},{"id":"GO:0032024","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0043524","count":4}]},{"hash":"37294906234229178","title":"Transmembrane Transporters for Xenobiotics and Ions","description":"The top terms point to broad transmembrane transport activity across substrates such as xenobiotics, vitamins, ions (sodium/potassium), and sugars (D-xylose, trehalose), indicating a cluster of membrane transporter proteins with wide substrate specificity. The unusual replication senescence term may be incidental. Therefore, the label reflects the core function: transmembrane transporters handling diverse substrates.","confidence":"High","size":20,"edges":56,"triangles":36,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":20},{"id":"GO:0006855","count":20},{"id":"GO:0071805","count":16},{"id":"GO:0042908","count":16},{"id":"GO:0042891","count":15}]},{"hash":"2137810914212697224","title":"Dopaminergic Feeding and Thermogenesis Signaling","description":"This cluster centers on neural control of energy balance, with terms for diet-induced thermogenesis, eating behavior, dopaminergic synaptic transmission, and GPCR-cGMP signaling, plus membrane potential regulation, suggesting a common dopaminergic pathway regulating feeding and thermogenesis.","confidence":"High","size":20,"edges":48,"triangles":16,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":13},{"id":"GO:0042391","count":13},{"id":"GO:0019233","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0018298","count":12}]},{"hash":"951908118236148975","title":"MVB Sorting and ESCRT-Mediated Degradation","description":"The cluster is dominated by GO terms for multivesicular body assembly and sorting, ubiquitin-dependent protein catabolism via the MVB sorting pathway, and membrane fission, which together point to ESCRT-driven vesicle trafficking and protein degradation. Additional terms about autophagy regulation and mitotic/nuclear organization likely reflect related cellular remodeling processes, but the core signal centers on MVB sorting and degradation. ","confidence":"High","size":20,"edges":17,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0036258","count":3},{"id":"GO:0071985","count":3},{"id":"GO:0007080","count":3},{"id":"GO:0006997","count":3},{"id":"GO:0043162","count":3}]},{"hash":"1878616366870006328","title":"RNA processing and genome maintenance","description":"This cluster centers on RNA processing events (mRNA splicing regulation, ncRNA-mediated silencing, rRNA maturation) and broader gene expression tasks (translation), alongside DNA replication and damage control processes (transcription-coupled NER, SOS response, primer synthesis). The combination suggests a shared theme of nucleic acid metabolism and genome maintenance rather than a single precise pathway, hence a high-level label like RNA processing and genome maintenance. ","confidence":"Medium","size":20,"edges":60,"triangles":86,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":9},{"id":"GO:0031047","count":9},{"id":"GO:0000462","count":7},{"id":"GO:0006412","count":6},{"id":"GO:0006260","count":5}]},{"hash":"942487715184986710","title":"Unknown","description":"This cluster's GO terms cover a wide range of processes from muscle cell homeostasis and digestion to transcription regulation, autophagy, hormone responses (estrogen) and plant-specific growth controls (ABA seed dormancy), plus myelin assembly. The diverse, seemingly unrelated contexts suggest no single cohesive function tying all proteins together, so a specific label cannot be confidently assigned.","confidence":"","size":20,"edges":39,"triangles":16,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0046716","count":3},{"id":"GO:0007586","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0071442","count":2},{"id":"GO:0046856","count":2}]},{"hash":"1784400887052794991","title":"Innate immune signaling and leukocyte activation","description":"The top GO terms cluster around innate immune sensing and signaling, including stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, and responses to fungal origin, all pointing to immune recognition and leukocyte activation. Some terms about lymph vessel morphogenesis may reflect immune cell trafficking rather than core signaling, and a few developmental terms appear incidental. Overall, the cluster represents a cohesive immune signaling module.","confidence":"High","size":20,"edges":109,"triangles":287,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":19},{"id":"GO:0060355","count":19},{"id":"GO:0036303","count":19},{"id":"GO:0072287","count":19},{"id":"GO:0071226","count":19}]},{"hash":"1388160484273178063","title":"Bacterial envelope biogenesis and metal transport","description":"Dominant terms point to surface-component synthesis (lipopolysaccharide and N-acetylneuraminate biosynthesis), phosphatase activity, and metal ion transport (copper and zinc), suggesting the cluster centers on building/maintaining the bacterial cell envelope and metal homeostasis. Some terms (epoxygenase P450 pathway, response to testosterone) are less connected, but the envelope and metal-transport themes are the strongest signal.","confidence":"Medium","size":20,"edges":167,"triangles":794,"max_degree":19,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0046839","count":6},{"id":"GO:0019373","count":6},{"id":"GO:0097755","count":6},{"id":"GO:0046272","count":6},{"id":"GO:0009103","count":5}]},{"hash":"2275447673633835999","title":"Proteasome-mediated ubiquitination and mitotic cell-cycle control","description":"The cluster is dominated by ubiquitin-related processes (K11/K48/K63 linkages, SCF, ERAD, autoubiquitination) and proteasome-mediated protein degradation, alongside mitotic cell-cycle terms (G2/M), with NF-kB signaling and embryonic development terms linking through degradation of regulators. This points to a cohesive theme of ubiquitin-proteasome\u2013driven regulation of cell-cycle progression and signaling.","confidence":"High","size":20,"edges":164,"triangles":755,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":14},{"id":"GO:0070979","count":14},{"id":"GO:0051865","count":13},{"id":"GO:0000278","count":12},{"id":"GO:0031146","count":12}]},{"hash":"1131421733589763740","title":"Spliceosome Assembly and Translation Initiation","description":"The proteins are enriched for spliceosome- and RNA processing-related functions (mRNA splicing, splice site recognition, small-subunit processome assembly) as well as components of translation initiation (preinitiation complex formation, eIF4F complex assembly, translation reinitiation). This points to a coherent theme of RNA maturation/processing linked to the assembly of the translation machinery.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0002188","count":11},{"id":"GO:0045292","count":10}]},{"hash":"2293454838239936554","title":"RNA Processing and Gene Expression","description":"The cluster prominently features RNA metabolism and gene expression processes: ribosomal subunit assembly and translation, mRNA splicing and export, pre-miRNA processing, ncRNA-mediated gene silencing, and transcription regulation. This combination suggests a cohesive role in linking transcription to RNA processing and translation. ","confidence":"Medium","size":20,"edges":155,"triangles":676,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000027","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0016973","count":3},{"id":"GO:0031047","count":3}]},{"hash":"619762199017121368","title":"Diverse biosynthesis and metabolism","description":"The top GO terms point to biosynthetic and metabolic processes across different organisms, including fungal toxin biosynthesis (verruculogen), ectoine biosynthesis/catabolism, fatty acid metabolism (methyl-branched fatty acids and alpha-oxidation), and steroid hormone biosynthesis (testosterone). This suggests a cluster of proteins involved in generating or processing small molecules rather than a single, cohesive pathway, with a few peripheral terms (like apoptotic cell recognition) likely representing noise. Hence a label reflecting broad biosynthetic/metabolic activity is most representative.","confidence":"Medium","size":20,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902181","count":5},{"id":"GO:0019491","count":5},{"id":"GO:0042400","count":5},{"id":"GO:0097089","count":5},{"id":"GO:0001561","count":5}]},{"hash":"1264278969949166855","title":"Steroid hormone signaling in brain and male development","description":"The top GO terms cluster around brain development (striatum and thalamus), male sex differentiation, and prostate gland development, with a unifying theme of steroid hormone receptor activity and signaling guiding development in neural and male reproductive contexts; immune-related terms appear secondary but not central, suggesting hormone-mediated development as the main function of this cluster. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0021756","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0021794","count":5},{"id":"GO:0006463","count":5},{"id":"GO:0046661","count":5}]},{"hash":"1829181907766038488","title":"Chromatin regulation and heterochromatin formation","description":"The top GO terms cluster around chromatin biology: pericentric heterochromatin formation, establishment of protein localization to chromatin, and negative regulation of transcription by RNA polymerase II, all indicating a module focused on chromatin organization and transcription control. Other terms are less coherent with this theme (e.g., Rho signaling, apoptosis), suggesting some annotation noise but not overriding the core chromatin-related signal. ","confidence":"Medium","size":20,"edges":11,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0051290","count":3},{"id":"GO:0031508","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0071169","count":3}]},{"hash":"1393894765209455271","title":"TLR2\u2013NF-\u03baB Immune Signaling Proteins","description":"The top GO terms show strong enrichment for innate immune signaling: Toll-like receptor 2 signaling and canonical NF-kappaB signal transduction, with positive regulation of NF-kappaB also prominent. While a few terms touch on cytokinesis and development, these are less represented. Thus, the cluster most plausibly centers on innate immune signaling, with possible secondary links to cell division processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000281","count":4},{"id":"GO:0034134","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0007249","count":4},{"id":"GO:0060378","count":3}]},{"hash":"56341525617077084","title":"NF-kappaB\u2013mediated immune signaling and vascular development","description":"Top terms converge on innate/adaptive immune signaling with NF-kappaB involvement (innate immune response, B cell receptor signaling, NK T cell differentiation) and processes related to endothelial barrier function and Rho/small GTPase signaling, plus heart and nervous system development. This points to a cohesive theme of NF-kappaB\u2013driven immune signaling integrated with vascular/developmental roles, rather than a narrow, single function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0090557","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007507","count":4}]},{"hash":"901230148287268920","title":"Immune-driven angiogenesis and ECM remodeling","description":"This cluster combines immune activation terms (complement activation, adaptive immune response) with vascular development (angiogenesis, endothelial cell migration) and extracellular matrix organization (collagen fibril organization), plus signaling via receptor tyrosine kinases and ERK cascade. This pattern suggests a coordinated program where immune responses intersect with blood vessel formation and ECM remodeling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0007171","count":10},{"id":"GO:0002250","count":9},{"id":"GO:0030199","count":8},{"id":"GO:0070374","count":8}]},{"hash":"1921394258836652375","title":"Developmental ECM remodeling and immune signaling","description":"This cluster shows terms tied to extracellular matrix (collagen/elastin) catabolism, immune pathways (blood coagulation, complement activation, LPS response), and multiple developmental processes (midbrain development, pancreas morphogenesis, axis specification), suggesting a theme of tissue remodeling during development with supporting immune signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0007596","count":7},{"id":"GO:0001867","count":7},{"id":"GO:0030901","count":6},{"id":"GO:0006958","count":6}]},{"hash":"437910795478293473","title":"Cell Cycle and Intracellular Trafficking","description":"This cluster centers on cell cycle and division terms (cell division, cell cycle) and includes several intracellular transport and organelle-related processes (ribosomal protein import into nucleus, anterograde synaptic vesicle transport, melanosome organization), suggesting a theme of coordinated cell growth with trafficking. Some terms (e.g., gravitropism, hyaluronan biosynthesis) are less clearly connected and may reflect broader annotations, but the core signal is cell cycle alongside intracellular transport.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0006610","count":2}]},{"hash":"993470354037943259","title":"Neural development and synaptic actin remodeling","description":"These proteins cluster around neural development and synaptic remodeling processes: substantia nigra development, myelination in the PNS, dendritic spine morphogenesis, podocyte differentiation (cytoskeletal context), and GPCR/acetylcholine receptor signaling, all tied to actin polymerization. The common theme is signaling events that coordinate cytoskeletal dynamics to drive neural differentiation and synapse formation. Some terms (bone development, muscle contraction) are less central or reflect broader cytoskeletal roles, but the neural development and synaptic terms predominate. Confidence: High","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021762","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0006936","count":2},{"id":"GO:0072112","count":2}]},{"hash":"2073947238718783869","title":"Embryonic craniofacial skeleton and nervous system development","description":"The set is dominated by GO terms for embryonic tissue morphogenesis and development, especially cranial skeleton ossification/morphogenesis, nervous system development, olfactory placode morphogenesis, and synapse assembly, with involvement of cell adhesion. While a complement activation term appears, the overall signal points to a cohesive developmental program shaping craniofacial structures and neural tissue, rather than an immune-focused cluster.","confidence":"Medium","size":20,"edges":20,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":16},{"id":"GO:0006958","count":14},{"id":"GO:0007275","count":14},{"id":"GO:0007399","count":13},{"id":"GO:0043931","count":13}]},{"hash":"44861355851720909","title":"Chromatin silencing and nuclear organization","description":"This cluster centers on chromatin state and nuclear processes, with GO terms for heterochromatin formation at silent loci, chromatin localization, transcriptional regulation by RNA polymerases II and I, cohesion maintenance during mitosis, and overall nucleus organization. These point to a cohesive function in chromatin-based transcriptional control and chromosomal/nuclear architecture.","confidence":"High","size":20,"edges":91,"triangles":148,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0051290","count":5},{"id":"GO:0071169","count":5},{"id":"GO:0030466","count":5},{"id":"GO:0008584","count":4}]},{"hash":"434800961559225125","title":"Immune Defense and Neural Signaling","description":"Top GO terms indicate strong immune-related roles (defense response to bacterium, complement activation, immunoglobulin production, peptidoglycan catabolic process) alongside nervous-system processes (GABA signaling, locomotory behavior, conditioned taste aversion, mechanosensory perception). This pattern suggests a cluster of proteins with dual involvement in immune responses and neural signaling, or multifunctional proteins bridging the two domains.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":8},{"id":"GO:0007626","count":7},{"id":"GO:0001661","count":7},{"id":"GO:0007214","count":7},{"id":"GO:0000187","count":6}]},{"hash":"1704133413110145081","title":"GPCR-Mediated Taste and Pain Signaling","description":"This cluster is dominated by GO terms tied to GPCR signaling pathways (glutamate receptor\u2013related pathways, PLC activation, and related G protein signaling) and sensory perception processes, including detection of sweet taste and regulation of pain, as well as GABA signaling. Together these indicate a coherent theme of neuronal GPCR-driven sensory signaling and nociception, with an additional immune-related term appearing as a secondary note. ","confidence":"High","size":20,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":14},{"id":"GO:0007626","count":13},{"id":"GO:0001661","count":13},{"id":"GO:0007214","count":13},{"id":"GO:0001582","count":12}]},{"hash":"412862949625717853","title":"NOD-like receptor signaling and cellular stress responses","description":"This cluster prominently features NOD-like receptor signaling pathways (GO:0070431, GO:0070427) with supporting processes such as protein ubiquitination (GO:0016567), ER stress\u2013induced apoptotic signaling (GO:0070059), and responses to mechanical stimuli, pointing to an innate immune and cellular stress\u2013response module.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070431","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0007205","count":3}]},{"hash":"281948417874544429","title":"Retroviral Entry, Integration, and Latency","description":"The cluster is dominated by GO terms tied to retroviral life cycle steps: entry of viral genomes into the host nucleus, reverse transcription (RNA-templated DNA synthesis), DNA recombination/replication, DNA integration, and establishment of integrated proviral latency. Additional terms about host cell cycle regulation and RNA silencing modulation fit with how retroviruses manipulate host processes to promote integration and persistence.","confidence":"Medium","size":20,"edges":167,"triangles":824,"max_degree":19,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":11},{"id":"GO:0006260","count":7},{"id":"GO:0075732","count":6},{"id":"GO:0006278","count":6},{"id":"GO:1903704","count":6}]},{"hash":"1536219519517529384","title":"Nervous system development and axonal cytoskeleton dynamics","description":"The terms point to neural development (astrocyte and Schwann cell development, neuron axonogenesis, neurofilament assembly, axonal transport, and microtubule polarity) and cytoskeletal organization, which together define a cohesive theme of neuronal maturation and cytoskeletal dynamics. Some outlier terms (lens fiber development, cornification) appear incidental and do not override the central nervous system signal.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070307","count":4},{"id":"GO:0019896","count":3},{"id":"GO:0070268","count":3},{"id":"GO:0030951","count":3},{"id":"GO:0055015","count":3}]},{"hash":"1179730570892515632","title":"Mitochondrial Transporters and Metabolism","description":"These proteins show enrichment for GO terms focused on transport of metabolites into and out of mitochondria (iron import, glycine import, alpha-ketoglutarate transport, ornithine transport), energy-related transport (mitochondrial ATP transmembrane transport), and metabolic shuttling (malate-aspartate shuttle). A few cell cycle/division terms are also present, which may reflect broader cellular coordination with division. Overall, the common thread is mitochondrial metabolite transport and energy metabolism, with some ancillary links to cell cycle processes. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0048250","count":2},{"id":"GO:0036233","count":2},{"id":"GO:0000066","count":2}]},{"hash":"971131034466262667","title":"Unknown","description":"The GO terms span several distinct biological themes (cytoskeletal organization, neuronal morphogenesis, apoptosis regulation, transcription control, peroxisome import, barrier formation, adipose development, and LPS signaling) with no clear single function tying the proteins together. The lack of shared pathway convergence and zero edges among proteins suggest a heterogeneous set rather than a cohesive cluster, so a concise, representative name is not evident.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007015","count":2},{"id":"GO:0060997","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060378","count":1}]},{"hash":"791317888438337796","title":"Embryonic placental and craniofacial development","description":"This cluster is dominated by embryonic development terms: roof of mouth development (GO:0060021) with many annotations, trophoblast giant cell differentiation (GO:0060707), and epithelial\u2013mesenchymal transition in placental-related contexts (GO:0003198). Additional terms point to placenta/embryonic organogenesis (e.g., endocrine system development, type B pancreatic cell development) and regulation of developmental processes, indicating a cohesive theme of embryonic morphogenesis and placental/craniofacial development. Some housekeeping processes (mRNA splicing, ribosomal export) appear, but the strongest signal centers on developmental differentiation and morphogenesis.","confidence":"Medium","size":20,"edges":33,"triangles":0,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":17},{"id":"GO:0060707","count":12},{"id":"GO:0003198","count":12},{"id":"GO:0000055","count":12},{"id":"GO:0032298","count":12}]},{"hash":"1951253620444673377","title":"Immune Signaling Regulation and Ubiquitination","description":"This cluster is dominated by GO terms that suppress or modulate immune signaling across multiple pathways (TLR3, NOD1, IL-1, IL-2, CD40) as well as B cell homeostasis. The concurrent emphasis on protein ubiquitination and K33-linked deubiquitination suggests regulation of signaling through ubiquitin-dependent mechanisms. Together, the terms point to a cohesive theme of immune signaling regulation via ubiquitination, with some transcriptional regulation aspects.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":2},{"id":"GO:0032495","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0001922","count":2},{"id":"GO:1990168","count":2}]},{"hash":"663620575773488018","title":"Embryonic Development and Placental Differentiation","description":"The top GO terms cluster around trophoblast giant cell differentiation, EMT related to placental formation, placenta and endocrine system development, and patterning events, pointing to embryonic tissue differentiation with a focus on placental/trophoblast lineages. While there are also general transcription and splicing terms, the dominant theme is embryonic development and placental differentiation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":19},{"id":"GO:0003198","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0035270","count":19},{"id":"GO:0003323","count":19}]},{"hash":"1365194574137057527","title":"Cell Cycle and Transcription Regulation","description":"GO terms center around cell cycle control (G1/S transition, cell division, general cell cycle) and transcription regulation (DNA-templated transcription, negative regulation of RNA polymerase II), plus ubiquitination and telomere maintenance. This points to a cluster of proteins involved in coordinating cell-cycle progression with transcriptional and post-translational regulation; peripheral terms like vasculogenesis, heat response, and sperm binding appear ancillary. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000045","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0007339","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2}]},{"hash":"1255605076446074364","title":"Dopaminergic synaptic signaling and feeding behavior","description":"This cluster centers on dopaminergic synaptic transmission and GPCR-cGMP signaling, with strong links to eating behavior, diet-induced thermogenesis, and sensory modulation (pain and temperature responses). The convergence of these GO terms points to a dopamine-driven signaling module influencing feeding/energy balance and related sensory processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":17},{"id":"GO:0002024","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0043547","count":17}]},{"hash":"497888131005237920","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"The top GO terms cluster around nervous system functions related to sensory perception and signaling, including pain perception, temperature stimulus responses, morphine responsiveness, visual perception, and dopaminergic synaptic transmission. The presence of ERK1/2 cascade regulation supports a neuronal signaling theme. While some terms touch on broader brain and cardiovascular components, the dominant pattern is neural sensory processing and signaling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0071380","count":11},{"id":"GO:0043278","count":11}]},{"hash":"1314572422932054754","title":"GPCR Calcium-cAMP Signaling in Sensory Responses","description":"The cluster mixes GPCR-related functions (internalization, adenylate cyclase activation) with calcium release and cAMP signaling, plus sensory-associated processes (pain perception, thermogenesis, temperature response) and phototransduction. This suggests a core theme of GPCR-driven calcium and cAMP signaling underlying multiple sensory and immune-related pathways, despite varied final outputs.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0002024","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0051209","count":12},{"id":"GO:0051482","count":11}]},{"hash":"1571465401787546165","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around embryogenesis and tissue morphogenesis across diverse tissues\u2014placenta/trophoblast differentiation, epithelial-to-mesenchymal transitions in heart development, cartilage and palate morphogenesis, hair follicle morphogenesis, and left-right patterning\u2014indicating proteins involved in broad developmental programs rather than a single pathway.","confidence":"High","size":20,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":19},{"id":"GO:0003198","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0003323","count":19},{"id":"GO:0035270","count":19}]},{"hash":"1703352158687710143","title":"Embryonic Development and Patterning","description":"The GO terms cluster around placental and trophoblast differentiation, epithelial-to-mesenchymal transition in heart development, and multiple aspects of embryonic organogenesis (endocrine system and pancreas development, cartilage morphogenesis, left-right patterning). Together they indicate proteins involved in vertebrate development and tissue patterning, with some regulatory processes and peripheral roles.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003323","count":6}]},{"hash":"1867459943192159054","title":"Embryonic Organogenesis and Patterning","description":"The top GO terms point to development and morphogenesis across multiple tissues (pancreas, placenta, cartilage, palate) and processes (left-right patterning, heart cushion formation) often governed by BMP signaling and transcriptional regulation during embryogenesis. This pattern suggests the cluster represents proteins involved in broad embryonic organogenesis and tissue patterning rather than a single specialized pathway.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0060707","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060806","count":5}]},{"hash":"1558290847684791124","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms are dominated by developmental processes across multiple tissues, including trophoblast giant cell differentiation (placenta), epithelial-to-mesenchymal transition in heart formation, placenta development, endocrine system development, cartilage morphogenesis, and left-right pattern formation, with additional morphogenesis terms like hair follicle development. This pattern suggests a cohesive theme of embryogenesis and organ/tissue morphogenesis rather than a single pathway, justifying a broad developmental label.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":20},{"id":"GO:0003198","count":20},{"id":"GO:0060806","count":20},{"id":"GO:0003323","count":20},{"id":"GO:0035270","count":20}]},{"hash":"1088598150443083449","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"The terms show a strong emphasis on ubiquitin-dependent protein catabolism, autoubiquitination, and diverse ubiquitin linkages, alongside innate immune and antiviral responses and NF-\u03baB/TNF signaling. This cluster likely groups proteins involved in ubiquitin-mediated regulation of immune signaling and proteasomal degradation during antiviral defense.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0045087","count":11},{"id":"GO:0051607","count":11},{"id":"GO:0051865","count":10},{"id":"GO:0085020","count":10}]},{"hash":"841599658103164458","title":"Muscle development and neural crest signaling","description":"The cluster centers on processes related to muscle differentiation/development (cardiac, skeletal, smooth) and neural crest\u2013derived tissues (neural crest migration, enteric nervous system development, bladder development), with signaling pathways like Rho and cytoskeletal remodeling linking these processes. This suggests proteins involved in coordinating muscle and neural crest\u2013derived tissue development and their signaling crosstalk.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001755","count":2},{"id":"GO:0001560","count":2},{"id":"GO:2000721","count":2},{"id":"GO:0007266","count":2},{"id":"GO:0060157","count":2}]},{"hash":"1252530659648615142","title":"RNA Processing and Ribosome Biogenesis","description":"This cluster's top GO terms center on RNA metabolism\u2014mRNA capping and guanine-N7 methylation\u2014and maturation of rRNA (5.8S and LSU), indicating ribosome biogenesis and RNA processing as the core function. Minor terms about stress responses and hormone biosynthesis are present but do not redefine the main theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":4},{"id":"GO:0006370","count":3},{"id":"GO:0061408","count":2},{"id":"GO:0042418","count":2},{"id":"GO:0042493","count":2}]},{"hash":"1272983844933209699","title":"Actin Cytoskeleton Remodeling and Cell Adhesion","description":"The top GO terms cluster around actin filament organization and dynamics (actin crosslink formation, actin filament network formation, actin cortical patch localization, actin filament-based movement), together with sarcomere organization, microspike assembly, cell polarity, and cell adhesion, all pointing to coordinated remodeling of the cytoskeleton and adhesion machinery. Regulation of Rho signaling further supports this theme. One IL-2 production term appears ancillary to the main cytoskeletal theme, which just reinforces the dominant actin/adhesion signature of this cluster.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0051764","count":3},{"id":"GO:0045214","count":2}]},{"hash":"240394875801308814","title":"Neuroimmune Signaling and Remodeling","description":"The GO terms point to immune sensing and signaling (lipopolysaccharide response, TLR2, NOD1) alongside neural development and signaling (axonogenesis, dopamine receptor signaling, synaptic potential regulation) and extracellular matrix remodeling (collagen fibril organization), suggesting a theme of signaling cross-talk between immune responses and neural processes with some ECM involvement.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0051770","count":4},{"id":"GO:1902499","count":4}]},{"hash":"2118141603185272753","title":"Developmental morphogenesis and tissue growth","description":"The top GO terms cluster around morphogenesis (dendrite and outer ear) and proliferation (mammary gland epithelial cell proliferation), with related signaling responses and DNA repair, suggesting proteins involved in developmental remodeling and tissue growth rather than a single enzymatic activity. This points to a developmental and growth-oriented functional theme for the cluster.","confidence":"Medium","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":19},{"id":"GO:1990804","count":19},{"id":"GO:0033598","count":19},{"id":"GO:0002688","count":19},{"id":"GO:0071380","count":19}]},{"hash":"2039635245214743596","title":"Ubiquitin-Driven Proteostasis and ERAD","description":"This cluster is dominated by GO terms tied to ubiquitin-dependent ER-associated degradation (ERAD), protein deubiquitination, and aggresome assembly, all central to proteostasis and handling of misfolded proteins. While there are additional terms related to signaling pathways (TNF, Wnt) and stress responses, these likely reflect multifunctional regulators rather than a single cohesive signaling module. The strongest signal is a coherent theme of ubiquitin-mediated protein quality control and degradation.","confidence":"High","size":19,"edges":132,"triangles":491,"max_degree":18,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":7},{"id":"GO:0016579","count":7},{"id":"GO:0070842","count":5},{"id":"GO:0033209","count":5},{"id":"GO:0051260","count":4}]},{"hash":"1714904491469521849","title":"Fungal immune recognition and receptor signaling","description":"This cluster centers on innate antifungal sensing and immune signaling, with strong representation of cellular response to fungal origin, C-type lectin receptor signaling, and Fc-gamma receptor signaling, plus related leukocyte activation and adhesion processes (platelet activation and adhesion molecule production). Some development-related terms (kidney morphogenesis) seem incidental, not core to the immune theme. ","confidence":"High","size":19,"edges":48,"triangles":69,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":13},{"id":"GO:0010572","count":13},{"id":"GO:0002223","count":12},{"id":"GO:0060355","count":12},{"id":"GO:0036303","count":12}]},{"hash":"918452826377121383","title":"Pollen exine formation and anther development","description":"This cluster is enriched for pollen-related processes, notably pollen exine formation and anther dehiscence, suggesting a role in male reproductive development. Additional GO terms point to pollen coat processing via N-linked glycosylation and nucleotide-sugar catabolic pathways (CDP, UDP, GDP), which support pollen wall biosynthesis and glycoprotein maturation. While some terms reflect general cellular processes such as DNA replication and protein homooligomerization, the recurrent pollen development signals indicate the dominant theme of pollen wall biosynthesis and anther opening.","confidence":"Medium","size":19,"edges":126,"triangles":418,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0046032","count":3},{"id":"GO:0071405","count":3},{"id":"GO:0006487","count":3}]},{"hash":"2122279321110220283","title":"Unknown","description":"The GO terms are highly diverse, including striatum development, cell division, redox/homeostasis, leucine and glycerol catabolism, cytolysis, capsule polysaccharide biosynthesis, cold response, and carbohydrate phosphorylation. With no edges or triangles connecting the proteins, there is no clear shared function or pathway linking these terms, suggesting the cluster comprises heterogeneous or spuriously grouped proteins. Therefore there is no cohesive theme to label; Unknown best captures the lack of a unifying function.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021756","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0006552","count":2},{"id":"GO:0019835","count":2}]},{"hash":"1736652390775700617","title":"Translation machinery and ribosome biogenesis","description":"Dominant GO terms center on translation and ribosome-related steps (initiation, termination, cytoplasmic termination, large subunit biogenesis, and disassembly), indicating a cluster of proteins that function in protein synthesis and ribosome dynamics. A few outliers (response to antibiotic, glial proliferation, siRNA-mediated heterochromatin regulation) are present but do not outweigh the translation-focused signal.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":16},{"id":"GO:0046677","count":5},{"id":"GO:0045903","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0006413","count":2}]},{"hash":"2230914428104320059","title":"Mitochondrial DNA synthesis and repair","description":"The GO terms cluster around mitochondrial maintenance: protein import into the mitochondrial matrix, nucleotide salvage and biosynthesis for deoxynucleotides, DNA repair, and DNA biosynthetic processes, alongside mitochondrial electron transport. This suggests a coordinated set of mitochondrial DNA replication/repair activities tied to nucleotide metabolism and energy production.","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0006180","count":2},{"id":"GO:0046092","count":2},{"id":"GO:0009157","count":2}]},{"hash":"2128497329064059407","title":"Neurodevelopment","description":"The set of top GO terms is dominated by neural and general organismal development, including forebrain development, neural tube closure, and multicellular organism development, suggesting a developmental role in the nervous system. While there are additional terms tied to cellular stress responses, mRNA processing, ribosome biogenesis, and ubiquitination, these appear as broader housekeeping or stress-related processes accompanying development. Overall, the cluster is best characterized as proteins involved in neural development with supporting cellular maintenance activities. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0050830","count":3}]},{"hash":"1034435892901636838","title":"Ion and nutrient transmembrane transporters","description":"This cluster is dominated by GO terms for transmembrane transport of ions and nutrients (e.g., sodium, potassium, nitrite/nitrate, sugars, sialic acid, vitamins), indicating a cohesive set of membrane transporter proteins rather than interaction networks.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035725","count":7},{"id":"GO:0042891","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0015739","count":6},{"id":"GO:0015707","count":6}]},{"hash":"508024638339964080","title":"Muscle\u2013neural development with synaptic signaling","description":"This cluster centers on nervous system and muscle development with synaptic signaling. Prominent GO terms include nervous system development, heart development, myoblast fusion, and glutamatergic synaptic transmission, plus synapse assembly and regulation of Rho signaling, pointing to morphogenesis, connectivity establishment, and cytoskeletal dynamics in neural and muscular tissues. Additional terms on apoptosis and ribosomal protein gene transcription reflect regulatory layers of development and gene expression; a lipopolysaccharide-related response may indicate broader signaling or stress interactions. Overall, the proteins appear linked to coordinated development of muscle and neural systems and their synaptic communication.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0031914","count":5},{"id":"GO:0035249","count":5},{"id":"GO:0007520","count":5}]},{"hash":"1312339849727625738","title":"CLR-driven innate immune signaling","description":"The top GO terms point to leukocyte activation and innate immune signaling, with emphasis on C-type lectin receptor signaling, fungal-origin responses, Fc receptor signaling, basophil activation, and NK cell chemotaxis regulation, suggesting a cluster centered on CLR-mediated pathogen recognition and downstream immune activation. Some developmental terms appear but are not central to the main theme.","confidence":"High","size":19,"edges":167,"triangles":903,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":19},{"id":"GO:0060355","count":19},{"id":"GO:0036303","count":19},{"id":"GO:0072287","count":19},{"id":"GO:0071226","count":19}]},{"hash":"620493423493950050","title":"RNA Pol II\u2013driven transcription with immune differentiation","description":"The top GO terms are dominated by RNA polymerase II\u2013mediated transcription and its regulation, indicating a transcription-centric cluster. The presence of macrophage differentiation, MHC class II biosynthesis, IL-4 signaling, and differentiation of adipocytes, osteoblasts, and liver-related processes suggests this module links transcriptional control with immune signaling and tissue differentiation across multiple lineages.","confidence":"Medium","size":19,"edges":159,"triangles":795,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0006351","count":9},{"id":"GO:0045348","count":8},{"id":"GO:0045600","count":8},{"id":"GO:0097421","count":8}]},{"hash":"1666699182695651409","title":"Cell-cycle control and DNA repair","description":"The cluster is dominated by GO terms tied to mitosis and chromosome handling (chromosome segregation, G2/M transition, exit from mitosis) and DNA repair (nucleotide-excision repair), plus ubiquitin-proteasome\u2013mediated degradation and ubiquitin chain formation, indicating a group of proteins coordinating cell-cycle progression with genome maintenance. Some other terms (peroxisome import, immune signaling) may be less central to the core function but do not override the main theme.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0007059","count":19},{"id":"GO:0070911","count":19},{"id":"GO:0016032","count":19},{"id":"GO:0031146","count":19},{"id":"GO:0000086","count":19}]},{"hash":"2280431557539908669","title":"Developmental transcriptional regulators","description":"The cluster is dominated by GO terms for DNA-templated transcription and transcriptional regulation, together with a range of embryonic organogenesis processes (pancreas, neural crest, muscle, ureteric branching, digestive tract morphogenesis, trachea cartilage, heart). This suggests a group of transcriptional regulators coordinating embryonic development and organ morphogenesis.","confidence":"High","size":19,"edges":127,"triangles":448,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0031018","count":11},{"id":"GO:0000122","count":11},{"id":"GO:0001755","count":10},{"id":"GO:0035914","count":10}]},{"hash":"1382588930681081381","title":"Vertebrate Embryonic Organogenesis","description":"The set is dominated by GO terms tied to embryonic development and organ morphogenesis (pituitary gland development, outflow tract morphogenesis, neural crest migration, embryonic eye morphogenesis, placenta development, etc.), suggesting a coherent theme of vertebrate embryogenesis and organ formation. Occasional stress-response terms (hypoxia, xenobiotic response) appear as background or secondary processes but do not override the central morphogenetic signal.","confidence":"High","size":19,"edges":31,"triangles":7,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0001666","count":4},{"id":"GO:0007584","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0021983","count":4}]},{"hash":"984918333321465800","title":"Axon guidance and neural development","description":"The top GO terms are dominated by neural development and connectivity: axon extension and guidance, retina layer formation, paranodal junction assembly, and synaptic vesicle endocytosis, all indicating processes that shape neural circuits. Additional terms point to general cell migration and vessel morphogenesis, likely reflecting coordinated developmental remodeling, though neural terms are the strongest signal. The inclusion of PI3K/AKT signaling regulation further supports growth and guidance pathways in neurons. Overall, the cluster appears centered on axon pathfinding and neural tissue development, with ancillary migratory processes.","confidence":"High","size":19,"edges":103,"triangles":218,"max_degree":15,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048842","count":13},{"id":"GO:0051897","count":11},{"id":"GO:0014909","count":11},{"id":"GO:0060982","count":11},{"id":"GO:0035767","count":10}]},{"hash":"441587524361751653","title":"Rho GTPase\u2013driven actin remodeling and adhesion signaling","description":"The terms cluster around actin cytoskeleton dynamics (filopodium assembly, actin branching, polymerization, podosome assembly) and small GTPase\u2013mediated signaling, with several receptor pathways (EGFR, ephrin, Wnt) feeding into adhesion and cell spreading. This points to a cohesive function in actin-driven remodeling coupled to adhesion signaling.","confidence":"High","size":19,"edges":15,"triangles":0,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046847","count":14},{"id":"GO:0007264","count":14},{"id":"GO:1900026","count":14},{"id":"GO:0050852","count":13},{"id":"GO:0090135","count":13}]},{"hash":"552243931252724901","title":"Stress-Response Signaling and Cytoskeletal Remodeling","description":"The top GO terms reflect signaling pathways activated by stress and external stimuli (NF-kappaB signaling, glucocorticoid response, xenobiotic response) plus downstream effects on cell structure and plasticity (actin crosslinking, Kv channel clustering, and long-term potentiation), suggesting a broad theme of stress-related signaling coupled with cytoskeletal remodeling. Heart development is less central but may relate to developmental signaling contexts, reinforcing the idea of diverse, signaling-driven processes rather than a single, cohesive function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0043123","count":4},{"id":"GO:0051384","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0043388","count":3}]},{"hash":"693825927403623479","title":"Innate Immune Signaling and Cytoskeletal Remodeling","description":"The cluster centers on innate immune processes (innate immune response, defense against virus, NF-kappaB signaling) and cytoskeletal dynamics (filopodium and stress fiber regulation, small GTPase signaling) with membrane repair, suggesting a link between immune signaling and cellular remodeling. A myelination term may reflect annotation breadth or cross-talk in nervous system contexts, but the core pattern is immune signaling plus cytoskeletal/membrane maintenance. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0022011","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0051489","count":3}]},{"hash":"871854144112468772","title":"Innate Immune Signaling and Phagocytosis","description":"Dominant GO terms point to innate immune activity and phagocytic processes (innate immune response, Fc-epsilon receptor signaling, type II interferon production, IL-2 production, and phagocytosis). A few terms touch on unrelated processes (spermatid development, sodium transport, microtubule regulation, fat cell proliferation), but the immune-related functions are the most consistently represented, suggesting the cluster centers on immune activation and engulfment mechanisms.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010765","count":4},{"id":"GO:0007026","count":4},{"id":"GO:0007286","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0045087","count":3}]},{"hash":"978030597932359336","title":"Rho-family GTPase signaling in synapse and spine remodeling","description":"The cluster is enriched in GO terms tied to small GTPase activity and signaling (e.g., positive regulation of GTPase activity, small GTPase-mediated signal transduction) and to synaptic processes (dendritic spine development, synaptic vesicle budding). These together point to a shared function in GTPase-driven control of the cytoskeleton, vesicle trafficking, and spine dynamics at synapses, with both promotion and inhibition of spine development reflected in the terms. The inclusion of cytokinesis-related terms also aligns with broader cytoskeletal regulation by Rho-family GTPases. ","confidence":"High","size":19,"edges":55,"triangles":67,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0007289","count":7},{"id":"GO:0060999","count":7},{"id":"GO:1902307","count":7},{"id":"GO:1902647","count":7}]},{"hash":"158317838592248021","title":"Mitochondrial import and redox stress in development","description":"The top GO terms point to mitochondrial processes (protein import into the mitochondrial matrix) alongside redox and metal homeostasis (cell redox homeostasis, copper ion homeostasis), stress responses (response to xenobiotic stimulus, apoptotic process), and developmental/neurodevelopment signals (pituitary gland development, forebrain development) with regeneration (fin regeneration) and behavioral outcomes. This combination suggests a theme of mitochondrial function and cellular stress interplay guiding development and regenerative processes, rather than a single isolated function.","confidence":"Medium","size":19,"edges":28,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0006878","count":2},{"id":"GO:0021983","count":2}]},{"hash":"445319132867681442","title":"Developmental Transcriptional Regulation and Differentiation","description":"This cluster shows strong enrichment for DNA-templated transcription and RNA polymerase II\u2013mediated transcription, with multiple terms for differentiation of skeletal muscle, myoblasts, melanocytes, osteoblasts, and outflow tract morphogenesis, suggesting proteins that regulate developmental gene expression guiding lineage specification.","confidence":"High","size":19,"edges":169,"triangles":936,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0006366","count":10},{"id":"GO:0003151","count":10},{"id":"GO:0035914","count":10},{"id":"GO:0045663","count":9}]},{"hash":"678235203144386895","title":"Broad Multicellular Development","description":"The top GO terms point to development across multiple organs and tissues (cardiac muscle, vascular smooth muscle, brain, spleen, uterus, and oral structures) along with the general multicellular organism development term, suggesting a broad developmental role rather than a single specific pathway. The presence of transcriptional regulation (negative regulation of transcription by RNA polymerase II) is also commonly involved in developmental control, supporting a general developmental theme for this cluster.","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055015","count":2},{"id":"GO:0035886","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1425692257230814092","title":"Lysosome and vesicle transport","description":"The top GO terms cluster around lysosome targeting (protein targeting to lysosome, Golgi to lysosome transport), endosomal/vesicle trafficking (vesicle-mediated transport, neurotransmitter receptor transport, anterograde synaptic vesicle transport, neurotransmitter receptor internalization), and related organelle organization (melanosome organization, protein storage vacuole organization). Together these indicate a coherent theme of intracellular vesicle trafficking focused on lysosome/endosome pathways, with neuronal transport features. A few terms are less directly tied (hyaluronan biosynthesis regulation, NK T cell differentiation) but do not outweigh the central trafficking signal.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006622","count":2},{"id":"GO:1900126","count":2},{"id":"GO:0098943","count":2},{"id":"GO:0051138","count":2},{"id":"GO:0090160","count":2}]},{"hash":"363381279850157948","title":"Hormone Secretion and GPCR-ERK Regulation","description":"This cluster centers on positive regulation of hormone release (growth hormone, prolactin, glucagon) and signals that drive secretion via GPCRs and the ERK cascade, with supporting calcium and cAMP signaling terms, suggesting a cohesive endocrine signaling theme.","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060124","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0035584","count":3},{"id":"GO:0019933","count":2},{"id":"GO:0070459","count":2}]},{"hash":"188866957404924796","title":"Ion and metabolite transporter cluster","description":"The GO terms are dominated by transmembrane transport of ions (sodium, potassium) and a range of nutrients (nitrite/nitrate, sialic acid, galactose, vitamin), with a metabolic term also present; together they indicate a group of membrane transport proteins collectively shuttling ions and small metabolites.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0042891","count":6},{"id":"GO:0015739","count":6},{"id":"GO:0015707","count":6}]},{"hash":"467118284430650075","title":"Cardiac signaling and vascular regulation","description":"The cluster\u2019s top GO terms center on heart development, regulation of cardiac muscle contraction, and vasoconstriction, pointing to cardiovascular signaling and muscle function. Supporting terms like ERK/MAPK cascade and GTPase regulation fit with signaling mechanisms governing cardiac/vascular activity. While there are other terms (platelet activation, morphine response, xenobiotic response) that are broader, they do not dominate the theme. Confidence: Medium.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0042742","count":2},{"id":"GO:0030168","count":2}]},{"hash":"2172164188447098206","title":"Developmental gene regulation and chromatin remodeling","description":"The top GO terms point to transcriptional regulation (negative regulation of RNA Pol II), chromatin remodeling and nucleosome assembly, together with a suite of embryonic and tissue-specific development processes (eye morphogenesis, nervous system development, blastocyst formation, primitive streak formation, stem cell maintenance). This suggests a coherent theme of developmental gene regulation coupled with epigenetic control, applicable across multiple developmental contexts beyond a single tissue. ","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0007601","count":3},{"id":"GO:0043010","count":3},{"id":"GO:1902262","count":3},{"id":"GO:0035019","count":3}]},{"hash":"53642344964643445","title":"Dopaminergic GPCR signaling and neural development","description":"Enrichment centers on dopaminergic synaptic transmission and GPCR signaling coupled to cGMP, with links to neural development and behavior (retina development, eating behavior, sensitization). Together these terms suggest a dopamine-mediated signaling module involved in neural development and plasticity, including retinal dopamine contexts.","confidence":"High","size":19,"edges":167,"triangles":907,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":19},{"id":"GO:0008284","count":19},{"id":"GO:0060041","count":19},{"id":"GO:0008283","count":19},{"id":"GO:0046960","count":18}]},{"hash":"2123375568061679067","title":"Dopaminergic neural signaling and sensory perception","description":"These proteins show strong enrichment for neural signaling and sensory processing GO terms, including dopaminergic synaptic transmission, visual perception and learning, and pain perception, as well as behavioral responses to cocaine. Additional terms indicate regulation of signaling pathways (ERK cascade, GTPase activity) that support neural activity. Some non-neural terms may reflect shared signaling components but do not outweigh the dominant neural/sensory theme. ","confidence":"High","size":19,"edges":122,"triangles":380,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001963","count":12},{"id":"GO:0071380","count":12},{"id":"GO:0048148","count":12},{"id":"GO:0010759","count":12},{"id":"GO:0070374","count":12}]},{"hash":"1370170190342394882","title":"RNA Processing and Translation Regulation","description":"The top terms point to RNA metabolism and translation control, including RNA guanine-N7 methylation, spliceosomal snRNP assembly, and initiation/reinitiation of translation, suggesting a cluster of proteins involved in RNA processing and protein synthesis regulation. Some terms like GTPase activity regulation and chromatin acetylation appear as broader or contextual functions, while the defense response term seems less tied to the core theme. Overall, the dominant pattern is RNA processing coupled with translation control.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1763814969612367796","title":"Proteostasis and ER quality control","description":"The cluster is enriched for ubiquitin-related processes (K63-linked ubiquitination; ubiquitin-dependent protein catabolic process) and the cellular response to misfolded protein, which together point to protein quality control and degradation. The SRP-dependent cotranslational targeting to membrane suggests involvement in secretory pathway processing, aligning with ER-associated protein handling. Although some terms touch on development and cell cycle, the strongest, coherent theme is proteostasis and ER quality control rather than a single developmental pathway. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0050966","count":3},{"id":"GO:0070534","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0071243","count":3}]},{"hash":"1464085188970792293","title":"Unknown","description":"The top terms indicate several unrelated processes: endocytosis, neuron projection development, metal stress response, erythrocyte differentiation, and chromatin-related events (with obsolete terms). There isn't a unifying function that ties these proteins together, so a specific functional label isn't supported; hence Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:0010976","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0043433","count":2},{"id":"GO:1901998","count":2}]},{"hash":"583784841663808319","title":"Embryonic vascular development and gene regulation","description":"The GO terms point to embryonic development and endothelial cell migration, with supported roles in vascular formation (Wnt signaling involvement and development terms) and broad gene-expression control (chromatin remodeling and transcription regulation). While coagulation/complement terms appear, the strongest overarching theme is development-related vascular processes coupled with transcriptional and chromatin regulation. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0007596","count":5},{"id":"GO:2000055","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0051965","count":4}]},{"hash":"559292535445853394","title":"Inflammation-driven vascular and coagulation signaling","description":"The most represented terms cluster around immune/inflammatory responses, vascular permeability regulation, prostaglandin signaling, and coagulation, with GPCR internalization and GTPase activity regulation supporting signaling dynamics. This suggests a cohesive function in inflammatory vascular signaling pathways and coagulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":11},{"id":"GO:0045907","count":11},{"id":"GO:0042493","count":10},{"id":"GO:0006955","count":10},{"id":"GO:0043114","count":10}]},{"hash":"2107502944878463291","title":"Synaptic transmission and neuronal excitability","description":"Top terms reveal excitatory postsynaptic potential, regulation of glutamatergic transmission, and sodium/potassium ion transport, pointing to neural signaling and membrane excitability. Behavioral terms like locomotory behavior and conditioned taste aversion further support a neural-behavior theme, though a couple of immune-related terms appear as outliers. Overall, the cluster is best described by synaptic transmission and neuronal excitability.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000187","count":11},{"id":"GO:0042742","count":11},{"id":"GO:0060079","count":10},{"id":"GO:0035725","count":9},{"id":"GO:0000186","count":9}]},{"hash":"1187032983772976379","title":"Immune cell adhesion and activation at cell junctions","description":"The prominent GO terms include both heterophilic and homophilic cell-cell adhesion and localization to cell junctions, alongside innate immune response features (complement activation) and regulation of T cell, macrophage, and NK activities, plus coreceptor-mediated virion attachment. This points to a module of proteins coordinating immune cell interactions at junctions and modulating immune activation.","confidence":"High","size":19,"edges":126,"triangles":419,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":13},{"id":"GO:0007156","count":13},{"id":"GO:0006958","count":12},{"id":"GO:1902414","count":11},{"id":"GO:0045087","count":11}]},{"hash":"2073229465960450712","title":"Neural development and morphogenesis","description":"This cluster is dominated by GO terms related to neural crest differentiation, neuroblast proliferation, neural tube closure, and sympathetic ganglion development, indicating a central theme of neural development. Additional morphogenesis terms (hair follicle and outflow tract morphogenesis) suggest broader developmental remodeling, all supported by receptor tyrosine kinase signaling and related pathways, which commonly drive developmental processes. Overall, the set points to neural development and tissue morphogenesis as the core theme. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045793","count":2},{"id":"GO:0007169","count":2},{"id":"GO:0014033","count":2},{"id":"GO:0003151","count":2},{"id":"GO:0031069","count":2}]},{"hash":"231729685161644726","title":"GPCR signaling in sensory and photoreceptor pathways","description":"The dominant GO terms point to G protein-coupled receptor signaling, including adenylate cyclase-activating and dopamine receptor pathways, prostaglandin response, and photoreceptor maintenance, indicating a cluster centered on GPCR-mediated sensory and retinal signaling. Additional terms like pain perception and blood pressure regulation fit within neural/vaso-regulatory GPCR roles, while electron transport and cell proliferation may reflect broader cellular functions in the set.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0045777","count":10},{"id":"GO:0035025","count":10}]},{"hash":"191712163413453340","title":"Unknown","description":"The cluster\u2019s GO terms cover very disparate areas: NF-kappaB signaling (canonical and non-canonical regulation), prostaglandin biosynthesis, GPI anchor biosynthesis, visual perception, and mitochondrial energy metabolism (oxidative phosphorylation and electron transport). This wide mix lacks a single cohesive biological function or pathway, making a precise, intuitive label inappropriate.","confidence":"","size":19,"edges":18,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0007249","count":2},{"id":"GO:0001516","count":2},{"id":"GO:1901223","count":2},{"id":"GO:0006506","count":2},{"id":"GO:0007601","count":2}]},{"hash":"1545478104992708833","title":"Embryonic organogenesis and heart development","description":"The cluster features GO terms linked to organ formation and patterning, particularly mesoderm/endoderm differentiation, organ induction, heart trabecula formation, and coronary vasculature development, alongside craniofacial/roof-of-mouth development. This suggests a cohesive developmental program driving organogenesis with a focus on heart and related structures, with supporting ECM and transcriptional regulation aspects. Confidence: High","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0060976","count":5},{"id":"GO:0006958","count":5}]},{"hash":"146087972591642207","title":"Innate antiviral defense and ubiquitin-mediated antigen processing","description":"This cluster is dominated by terms tied to antiviral innate immunity (innate immune response, defense against virus) and to ubiquitin-related processing (ubiquitin-dependent protein catabolic process, autoubiquitination, K6-linked ubiquitination). The presence of MHC class I biosynthesis regulation and negative regulation of intracellular transport of viral material links these proteins to antigen presentation and restricting viral trafficking, aligning with antiviral defense mechanisms. A few terms touch adaptive immunity (V(D)J recombination), but the prevailing theme remains innate antiviral response combined with ubiquitin-regulated protein turnover and antigen processing.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":14},{"id":"GO:0051607","count":14},{"id":"GO:0042787","count":14},{"id":"GO:0007026","count":12},{"id":"GO:0007182","count":11}]},{"hash":"163920969279473536","title":"Ubiquitin-Dependent NF-\u03baB/TNF Signaling Regulation","description":"The cluster is dominated by terms for ubiquitin-dependent protein degradation and autoubiquitination, along with multiple GO terms tied to TNF signaling and NF-\u03baB activation (including I\u03baB phosphorylation). This points to a set of proteins involved in ubiquitin-mediated control of inflammatory signaling pathways, with possible ties to immune processes such as V(D)J recombination.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0051865","count":12},{"id":"GO:0090073","count":12},{"id":"GO:1901253","count":11},{"id":"GO:1903265","count":11}]},{"hash":"951391203368715721","title":"Vesicle Exocytosis and Synaptic Signaling","description":"The GO terms point to vesicle fusion and release processes (acrosome reaction, neurotransmitter secretion) and neuronal signaling and plasticity (long-term synaptic depression, learning, sensory perception of sound). Although there are a few non-neuronal terms (lens morphogenesis, angiogenesis), the dominant pattern centers on vesicle-mediated signaling and exocytosis in neural contexts.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":3},{"id":"GO:0016540","count":2},{"id":"GO:0070309","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0007605","count":2}]},{"hash":"184711046608683827","title":"Multilineage Differentiation","description":"This cluster's top GO terms are dominated by differentiation events across neural (cerebellar granule cell differentiation, oligodendrocyte differentiation) and adipose (fat cell differentiation) lineages, along with epithelial polarization and actin filament bundle assembly, suggesting a theme of differentiation coupled with cellular organization. Some terms (telomere maintenance, NF-kappaB sequestration, cardiac signaling) seem less connected to a single cohesive function, possibly reflecting broader or context-dependent roles or annotation noise. Thus a label of Multilineage Differentiation captures the main recurring signal while acknowledging heterogeneity.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":4},{"id":"GO:0048709","count":4},{"id":"GO:0032212","count":3},{"id":"GO:0070198","count":3},{"id":"GO:0086070","count":3}]},{"hash":"1915117078450635969","title":"Unknown","description":"The top GO terms span plant, bacterial, and animal processes (chlorophyll catabolic process, beta-ketoadipate pathway, phospholipid dephosphorylation, uracil catabolic process, P450 epoxygenase pathway, cellular oxidant detoxification, antibiotic biosynthetic process, and endocannabinoid signaling regulation). There is no clear shared function that unites all 19 proteins, so a single informative label cannot be assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0015996","count":5},{"id":"GO:0046839","count":5},{"id":"GO:0042952","count":5},{"id":"GO:0009086","count":5},{"id":"GO:0019373","count":5}]},{"hash":"1843187028169868442","title":"Unknown","description":"The top terms span telomere maintenance, chromosome localization, cardiac signaling, immune and NF-kappaB-related pathways, epithelial polarity, cytoskeletal organization, adipocyte differentiation, and neuronal development. This broad, unrelated mix suggests there is no single cohesive function tying the cluster together, so a specific label isn\u2019t justifiable.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"establishment or maintenance of cell polarity","top_go_terms":[{"id":"GO:0032212","count":4},{"id":"GO:0070198","count":4},{"id":"GO:0086070","count":4},{"id":"GO:0007253","count":4},{"id":"GO:1900827","count":4}]},{"hash":"1849300140524354065","title":"Neural development and actin dynamics","description":"Based on the GO terms, the cluster is enriched for neural development (brain development; dendritic spine development) and actin cytoskeleton regulation (positive regulation of Arp2/3 complex-mediated actin nucleation), suggesting a theme of actin-driven neural morphogenesis. Other terms indicate general stress responses or trafficking, but the strongest signal ties neural development to actin remodeling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001403","count":3},{"id":"GO:2000601","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0000011","count":2}]},{"hash":"855274413272299848","title":"Wnt signaling regulators in development","description":"The terms show a strong emphasis on regulation of canonical Wnt signaling (both activation and repression), along with developmental processes (blastocyst development, dendritic spine morphogenesis) and apoptosis; other terms indicate broader roles in signaling regulation (GTPase activity, mRNA stability) and some immune and neural-related functions. This supports a core theme of signaling pathway regulation during development, with ancillary roles in immunity and neural biology.","confidence":"Medium","size":18,"edges":137,"triangles":592,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":4},{"id":"GO:0001824","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0045476","count":3},{"id":"GO:0043488","count":3}]},{"hash":"1272741934208851650","title":"Neural crest and eye development","description":"The cluster is enriched with GO terms targeting neural crest cell migration and multiple eye-related morphogenesis processes (embryonic eye morphogenesis, camera-type eye development, habenula development), indicating a coherent developmental program governing neural crest derivatives and ocular formation. Additional terms for hypothalamus differentiation and pancreas development suggest broader neurodevelopmental regulation, but the strongest signal centers on neural crest\u2013eye development. ","confidence":"High","size":18,"edges":79,"triangles":85,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0021986","count":10},{"id":"GO:0006366","count":9},{"id":"GO:0001755","count":9},{"id":"GO:0048048","count":9}]},{"hash":"467756563307513036","title":"Autophagy and organelle turnover","description":"The top GO terms cluster around autophagy-related processes: autophagosome maturation, autophagy of mitochondrion, and protein targeting to vacuole involved in autophagy, plus piecemeal microautophagy of the nucleus and vesicle localization. The association with microtubule cytoskeleton organization suggests transport of autophagosomes along microtubules, reinforcing the autophagy theme. Some death-related terms (extrinsic apoptotic signaling, necrotic cell death regulation) indicate cross-talk between autophagy and cell death pathways, which is common in stress responses. Overall, these proteins likely participate in autophagy-driven organelle turnover and related trafficking.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0000226","count":7},{"id":"GO:0097352","count":6},{"id":"GO:0034629","count":6},{"id":"GO:0071280","count":6},{"id":"GO:0071211","count":6}]},{"hash":"276957232162575088","title":"Dopaminergic Neural Signaling and Cocaine-Related Behavior","description":"The cluster shows strong signals for dopaminergic synaptic transmission, visual perception/learning, and a behavioral response to cocaine, pointing to neural signaling and reward pathways. ERK1/2 cascade regulation supports learning-related plasticity, reinforcing a brain-focused theme. Some terms (dsRNA response, prostaglandin stimulus, heart development) are broader or peripheral hints, but do not outweigh the dominant neural/reward-related signals.","confidence":"Medium","size":18,"edges":119,"triangles":377,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043330","count":13},{"id":"GO:0071333","count":13},{"id":"GO:0071380","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0007601","count":9}]},{"hash":"1883493988156576155","title":"Vision and dopaminergic neural signaling","description":"The cluster is dominated by terms for visual perception and learning, along with dopaminergic synaptic transmission and behavioral responses to cocaine, all pointing to vision-related neural activity and dopamine-mediated reward signaling. ERK cascade regulation further supports a signaling/learning theme, while a few peripheral terms (heart development, macrophage chemotaxis) are likely pleiotropic. ","confidence":"Medium","size":18,"edges":44,"triangles":35,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":17},{"id":"GO:0070374","count":17},{"id":"GO:0007601","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0007507","count":17}]},{"hash":"1740099094490986407","title":"Mitotic Spindle and Microtubule Dynamics","description":"This cluster is dominated by GO terms tied to microtubule organization and mitotic machinery, including metaphase chromosome alignment, spindle elongation, minus-end directed microtubule sliding, and maintenance of microtubule polarity, which collectively point to mitotic spindle dynamics and cytoskeletal control. Additional terms related to development, stress granule disassembly, and neuronal projection maintenance reflect broader roles of cytoskeletal and RNA granule processes, but the core signal is microtubule-driven mitosis. ","confidence":"High","size":18,"edges":118,"triangles":431,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0001560","count":6},{"id":"GO:0007080","count":6},{"id":"GO:0030951","count":6},{"id":"GO:0072092","count":6},{"id":"GO:0000911","count":6}]},{"hash":"2304771605006898030","title":"Meiosis and germ cell development","description":"The top terms are dominated by meiotic processes (meiotic joint molecule formation, double-strand break repair in meiotic recombination, male meiosis I) and germline development (germarium-derived oocyte fate determination), with supporting DNA replication/recombination terms. This mix suggests a functional cluster centered on meiotic DNA processing and germ cell fate specification, rather than general replication or protein oligomerization. ","confidence":"High","size":18,"edges":104,"triangles":331,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006310","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0090305","count":4},{"id":"GO:0006261","count":4}]},{"hash":"1796243046988387516","title":"Signaling and vesicle trafficking regulation","description":"The top GO terms cluster around regulation of signaling pathways (Rho, JNK), vesicle trafficking and related autophagy (Cvt pathway, synaptic vesicle exocytosis), and morphogenic processes (mating projection initiation, brain development), with additional mechanical stimulus response. This suggests a common theme of controlled signal transduction integrated with vesicle movement and cellular remodeling across diverse contexts. Therefore, the label Signaling and vesicle trafficking regulation captures the main functional thread.","confidence":"Medium","size":18,"edges":32,"triangles":13,"max_degree":7,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0031384","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0035023","count":4},{"id":"GO:0032729","count":4}]},{"hash":"2129632427101483370","title":"Nervous system development and myelination","description":"The top GO terms are dominated by nervous system-related processes: nervous system development, corpus callosum development, myelination, synapse assembly, and axon guidance (Roundabout signaling). These collectively indicate roles in neuronal maturation, connectivity, and insulation, outweighing a few less central terms like heart development. Thus the cluster is best described as neural development and myelination.","confidence":"High","size":18,"edges":32,"triangles":15,"max_degree":7,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007507","count":11},{"id":"GO:0051092","count":10},{"id":"GO:0046007","count":8},{"id":"GO:0035234","count":8},{"id":"GO:0042552","count":8}]},{"hash":"2031833676459680902","title":"Embryogenesis and organogenesis","description":"The cluster\u2019s GO terms cluster around embryonic development across diverse tissues\u2014embryonic development in general, placental and eye morphogenesis, outflow tract morphogenesis, pituitary and neuronal differentiation, and digestive tract development\u2014suggesting proteins involved in broad organogenesis rather than a single pathway. The presence of a single immune term (response to lipopolysaccharide) appears peripheral to the main developmental theme. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0071542","count":5},{"id":"GO:0048565","count":5},{"id":"GO:0001701","count":4},{"id":"GO:0032496","count":4}]},{"hash":"1151259449579582020","title":"Humoral and Fc receptor\u2013mediated immune defense","description":"The cluster is dominated by immune-related GO terms: immunoglobulin production, defense response to bacterium, innate immune response, detection of peptidoglycan, and Fc-gamma receptor signaling in phagocytosis, suggesting coordination of humoral and phagocytic innate defense. A few terms like atrial cardiac muscle cell action potential appear as odd or incidental annotations, but the prevailing theme centers on immune recognition and clearance of bacteria, including antibody-mediated and Fc receptor\u2013driven processes.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002377","count":3},{"id":"GO:0014070","count":2},{"id":"GO:0042742","count":2},{"id":"GO:0038096","count":2},{"id":"GO:0086014","count":2}]},{"hash":"239212602483815332","title":"Eye and Brain Development","description":"These terms cluster around formation of the nervous system and sensory organs, especially eye/retina development and visual perception, with supporting signals for brain and midbrain development and peripheral nervous system neurons. The combination suggests proteins involved in vertebrate neural and visual system organogenesis, despite some broad transcription regulation terms.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0021983","count":7},{"id":"GO:0048839","count":7},{"id":"GO:0060041","count":7},{"id":"GO:0007420","count":7}]},{"hash":"2250081663027902671","title":"Macrophage Lipid Signaling and Innate Immunity","description":"The proteins are enriched for macrophage activation, foam cell differentiation, lipid storage and remodeling, prostaglandin and leukotriene biosynthesis, antibacterial humoral responses, and mucosal innate immunity. This points to a cohesive theme where macrophage-driven inflammatory signaling is tightly linked to lipid mediator production and lipid remodeling, including ERK pathway regulation, consistent with innate immune responses in mucosal tissues.","confidence":"High","size":18,"edges":48,"triangles":26,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0010744","count":8},{"id":"GO:0010884","count":6},{"id":"GO:0032308","count":6},{"id":"GO:0019731","count":6}]},{"hash":"682416472188686561","title":"Neuronal Mitochondrial Function and Signaling","description":"This cluster shows enrichment for mitochondrial import and regulation of membrane permeability alongside neural processes such as synaptic transmission, learning, and fear behavior, suggesting proteins that coordinate mitochondrial function with neuronal signaling. Additional terms on cilium assembly and ion transport indicate broader cellular regulation, but the dominant theme centers on neural activity linked to mitochondria.","confidence":"Medium","size":18,"edges":18,"triangles":8,"max_degree":8,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0030150","count":4},{"id":"GO:0046902","count":3},{"id":"GO:0001662","count":3},{"id":"GO:0031101","count":3},{"id":"GO:0007270","count":3}]},{"hash":"5641720116826330","title":"Growth factor signaling and chemotaxis","description":"The top GO terms point to signaling cascades triggered by growth factors and cytokine-like stimuli (PDGF, M-CSF, TGF-beta, insulin, retinoic acid) and include cell-cell signaling and neutrophil chemotaxis, as well as STAT phosphorylation and PI3K regulation. This suggests a cluster of proteins involved in transmitting growth factor\u2013 and immune-related signals that drive cell migration, hence the label.","confidence":"Medium","size":18,"edges":18,"triangles":12,"max_degree":9,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043552","count":14},{"id":"GO:0042531","count":14},{"id":"GO:0014911","count":14},{"id":"GO:0032869","count":14},{"id":"GO:0030593","count":14}]},{"hash":"1121258164512412999","title":"Actin Cytoskeleton and Organelle Inheritance","description":"The cluster shows strong signals for actin cytoskeleton dynamics, including Arp2/3-mediated nucleation, actin cortical patch assembly, and sarcomere organization, along with organelle inheritance terms like vacuole and mitochondrion inheritance. This points to a cohesive role in actin-driven cytoskeletal organization and the distribution of organelles during cell processes, with a fungal-specific note from ascospore wall assembly. Overall, the dominant theme is actin-mediated cytoskeleton organization coupled with organelle inheritance.","confidence":"High","size":18,"edges":150,"triangles":770,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0034314","count":15},{"id":"GO:0030476","count":15},{"id":"GO:0051592","count":15},{"id":"GO:0000011","count":15},{"id":"GO:0045214","count":15}]},{"hash":"549323549313133213","title":"Neural Development and Cell Adhesion","description":"The GO terms cluster around nervous system development (neural tube closure, lateral motor column neuron migration, retina development, Schwann cell development, photoreceptor axon guidance) and adhesion/remodeling processes (hemidesmosome assembly, receptor clustering, substrate adhesion-dependent spreading). Together they indicate a group of proteins involved in neuronal development and cell\u2013ECM/cell\u2013cell adhesion. Some terms, like platelet aggregation, are less central but do not override the core theme.","confidence":"High","size":18,"edges":124,"triangles":424,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0090179","count":10},{"id":"GO:0043113","count":10},{"id":"GO:0031581","count":8},{"id":"GO:0034446","count":8},{"id":"GO:0070527","count":8}]},{"hash":"622789647112380274","title":"Innate Immune Signaling and Cell-Cell Adhesion","description":"The cluster centers on terms for innate immune response and immunoglobulin production, plus multiple adhesion-related terms (homophilic/heterophilic cell\u2013cell adhesion) and immune regulatory processes, suggesting proteins that mediate immune signaling and cell\u2013cell interactions. Some development and synapse-related terms may reflect shared adhesion or signaling pathways, but the dominant theme ties immune activity to cell adhesion.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0051092","count":7},{"id":"GO:0007157","count":6},{"id":"GO:0002377","count":6}]},{"hash":"592222208550226155","title":"Mitochondrial Translation and Oxidative Phosphorylation","description":"This cluster centers on mitochondrial functions, with GO terms for translation and for mitochondrial electron transport and ATP synthesis, indicating a group of proteins involved in mitochondrial protein synthesis and energy production. Additional biosynthetic terms (lipoate, thiamine, heme precursor) align with mitochondrial cofactor biosynthesis, supporting a mitochondria-focused metabolism theme. Overall, the dominant connectivity around translation and respiration justifies this label.","confidence":"High","size":18,"edges":101,"triangles":216,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006120","count":2},{"id":"GO:0042775","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0030488","count":1}]},{"hash":"281836651118889713","title":"Rho GTPase Signaling","description":"The top GO terms center on Rho protein signal transduction, regulation of GTPase activity, and related signaling cascades (including calcineurin-NFAT and dephosphorylation), suggesting the proteins collectively participate in Rho GTPase\u2013driven signal transduction. Some terms appear peripheral (e.g., visual perception, ascospore formation), but the core theme is consistent with Rho/GTPase signaling regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":4},{"id":"GO:0019933","count":3},{"id":"GO:0090179","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0070886","count":3}]},{"hash":"1553100286774382513","title":"Nuclear import and nuclear envelope reassembly","description":"The cluster\u2019s GO terms are dominated by nuclear-related processes: ribosomal protein import into the nucleus, NLS-bearing protein import into the nucleus, nuclear pore complex assembly, and mitotic nuclear membrane reassembly, suggesting a core theme of nuclear transport and envelope remodeling during the cell cycle. Additional terms about transcription by RNA polymerase III and regulation of phosphorylation/kinase activity point to associated nuclear signaling. Some items (e.g., extrinsic apoptotic signaling in absence of ligand, amino acid stimulus response) are less cohesive with this core theme, making the label centered on nuclear transport and envelope dynamics the most representative.","confidence":"Medium","size":18,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0033674","count":4},{"id":"GO:0060188","count":3},{"id":"GO:2001241","count":3},{"id":"GO:0071230","count":3},{"id":"GO:0051292","count":3}]},{"hash":"2021888563502767176","title":"Immune signaling and vesicle trafficking","description":"This cluster centers on immune-related signaling (positive regulation of JNK cascade, Th1 type immune response) and membrane/vesicle dynamics (ER-to-Golgi transport, vesicle endocytosis) with supporting themes of lipid homeostasis and cytoskeletal remodeling (stress fibers, mechanical stimulus). While ossification appears, the dominant shared functions appear to be signaling and trafficking in immune-related contexts.","confidence":"Medium","size":18,"edges":22,"triangles":10,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055091","count":9},{"id":"GO:0010628","count":9},{"id":"GO:0046330","count":9},{"id":"GO:0042088","count":9},{"id":"GO:0071260","count":9}]},{"hash":"159887827018480130","title":"Rho GTPase-driven actin remodeling and adhesion","description":"The top GO terms cluster around small GTPase signaling (especially Rho), actin cytoskeleton organization, and cell spreading/adhesion, plus tight junction assembly. This points to a cohesive function where Rho GTPases regulate actin dynamics and cell\u2013cell adhesion, with possible neural-context roles in synaptic plasticity and myelin maintenance.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":4},{"id":"GO:0035023","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0032287","count":3}]},{"hash":"1630471798743065638","title":"Innate Immune Activation and Pyroptosis","description":"These proteins collectively highlight innate immune signaling and inflammatory cell death, with strong signals for innate immune response, pyroptotic inflammation, and IL-1\u03b2 production. Ubiquitination and apoptotic process terms suggest regulation of cell death pathways, while actin filament remodeling points to cytoskeletal changes tied to inflammation. The mitotic spindle term may reflect shared cytoskeletal components rather than a core mitotic function, indicating a cluster centered on inflammation with ancillary cytoskeletal dynamics.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090307","count":9},{"id":"GO:0045087","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0070269","count":7},{"id":"GO:1990001","count":7}]},{"hash":"900522745142481320","title":"Lens development and visual perception","description":"This cluster is dominated by GO terms related to eye and lens biology, including camera-type eye development, lens fiber cell development/differentiation/morphogenesis, and lens development in the camera-type eye, plus visual perception, indicating a cohesive theme around lens formation and visual function. Some terms (lipopolysaccharide response, blood coagulation, pituitary development) appear as noise or incidental annotations, but do not override the core lens/eye focus.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":5},{"id":"GO:0043010","count":5},{"id":"GO:0070307","count":4},{"id":"GO:0002009","count":4},{"id":"GO:0070309","count":4}]},{"hash":"9712310296453881","title":"Forebrain development and ribosome biogenesis","description":"This cluster is driven by developmental processes, especially forebrain development and multicellular organism development, alongside key components of the protein synthesis machinery\u2014ribosome biogenesis, translation initiation, and translation reinitiation\u2014suggesting a group of proteins involved in neural development that also regulate translation. Ancillary terms like ER stress response and ERAD are present but not central to the main theme. ","confidence":"Medium","size":18,"edges":39,"triangles":35,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0001731","count":5},{"id":"GO:0008283","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0042254","count":5}]},{"hash":"2027644507260327807","title":"Wnt-driven morphogenesis and mechanotransduction","description":"These proteins cluster around canonical Wnt signaling promoting morphogenesis (e.g., hair follicle morphogenesis), ERK pathway regulation, adherens junction organization, tissue growth, and cellular responses to mechanical stimuli. The common thread is developmental signaling guiding morphogenesis and mechanotransduction across tissues.","confidence":"Medium","size":18,"edges":27,"triangles":7,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":6},{"id":"GO:0090263","count":4},{"id":"GO:0031069","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0043524","count":4}]},{"hash":"712907388417470573","title":"Neuronal Plasticity and Axon Guidance","description":"This cluster is dominated by neural-focused terms: long-term synaptic depression and potentiation point to synaptic plasticity, axonal fasciculation and Rho signaling relate to axon guidance and cytoskeletal dynamics, and social behavior reflects neural circuit function. While there are outliers (ubiquitination and apoptosis, and a few immune-related hints), the core signals consistently describe neuronal connectivity and remodeling.","confidence":"High","size":18,"edges":19,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":5},{"id":"GO:0035176","count":5},{"id":"GO:1900273","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0000209","count":3}]},{"hash":"2287369105790333360","title":"GTPase-driven immune signaling and migration","description":"The top GO terms cluster around GPCR internalization, small GTPase signaling (Rho/Ras), cytoskeletal remodeling (lamellipodium assembly, cell spreading), and cell migration, with immune-related terms (NK T cell differentiation, B cell affinity maturation) suggesting lymphocyte signaling roles. Together they indicate a set of proteins coordinating signaling and cytoskeletal dynamics to drive immune cell movement and interactions. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002031","count":15},{"id":"GO:0001865","count":15},{"id":"GO:0007264","count":15},{"id":"GO:0032287","count":15},{"id":"GO:0035023","count":15}]},{"hash":"1016958984588383162","title":"Unknown","description":"The terms cluster around redox detoxification and core transcription/biogenesis processes (RNA polymerase II/III and ribosome biogenesis). There isn't a single coherent function tying these categories together, suggesting either a broad, mixed set of roles or annotation noise. ","confidence":"","size":18,"edges":40,"triangles":41,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0015937","count":3},{"id":"GO:0006386","count":2}]},{"hash":"913031119163204011","title":"DNA Repair and Genome Maintenance","description":"The cluster is driven by strong enrichment for DNA-focused terms: DNA recombination (8), base-excision repair (8), and DNA replication (5), which together point to genome maintenance and repair processes as the core theme. There are additional, more peripheral terms such as xenobiotic response and redox signaling that appear less consistently, suggesting secondary roles or annotation noise within the group. Overall, the dominant DNA repair signals justify labeling the cluster as DNA Repair and Genome Maintenance.","confidence":"High","size":18,"edges":25,"triangles":5,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":8},{"id":"GO:0006284","count":8},{"id":"GO:0007568","count":7},{"id":"GO:0042493","count":5},{"id":"GO:0006260","count":5}]},{"hash":"1323812715326732114","title":"Neuronal signaling and sensory processing","description":"The dominant GO terms describe ion transport across membranes, membrane depolarization, excitatory postsynaptic potentials, action potentials, postsynaptic membrane organization, and sensory processing, pointing to proteins involved in synaptic transmission and nervous system signaling. A minority of terms (e.g., acrosome-related regulation) are less central but do not negate the neural signaling theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0050910","count":5},{"id":"GO:0051899","count":5},{"id":"GO:0060079","count":5}]},{"hash":"1161881645014366753","title":"Neural development and sensory organogenesis","description":"The top GO terms cluster around neural development and sensory organ formation (neural crest formation, brain segmentation, rhombomere development, retina development, pituitary gland development) and include broad transcriptional control (RNA polymerase II transcription, DNA-templated transcription). This suggests a group of proteins involved in neural patterning and sensory organogenesis with transcriptional regulation as a common mechanism.","confidence":"High","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0060041","count":8},{"id":"GO:0035284","count":7},{"id":"GO:0021571","count":7},{"id":"GO:0021983","count":7}]},{"hash":"529592958750415252","title":"Embryonic Tissue Morphogenesis and Differentiation","description":"The GO terms point to diverse developmental processes across tissues (placenta, hair follicle, cerebellum/ Purkinje cells, EMT in heart), highlighting differentiation and morphogenesis rather than a single biochemical pathway. While some terms like viral processes and ubiquitination regulation are present, the dominant pattern is embryonic tissue formation and cell fate differentiation, suggesting a broad developmental role for this cluster.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902499","count":3},{"id":"GO:0060707","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0021942","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1070947943140395106","title":"Embryonic Organogenesis","description":"This cluster centers on developmental processes across several organs (eye, pancreas, bone, brain, heart), including eye lens differentiation and pancreas development; the common thread is organogenesis and tissue differentiation rather than a single pathway.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043010","count":7},{"id":"GO:0007601","count":6},{"id":"GO:0070306","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0031018","count":5}]},{"hash":"612083842189784791","title":"Dopaminergic Synaptic Transmission and Cocaine Response","description":"The cluster is dominated by terms tied to dopaminergic signaling and synaptic plasticity, including dopaminergic synaptic transmission, GPCR internalization, ERK cascade regulation, and behavioral responses to cocaine, pointing to dopamine-mediated neural signaling and drug-related plasticity. While terms like visual perception and heart development appear, the strongest common theme is dopamine-based neurotransmission and cocaine-associated signaling.","confidence":"High","size":18,"edges":145,"triangles":703,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":17},{"id":"GO:0070374","count":17},{"id":"GO:0007601","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0007507","count":17}]},{"hash":"729732501004413786","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":17,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0043303","count":2},{"id":"GO:0019722","count":2},{"id":"GO:0042113","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0001963","count":2}]},{"hash":"690305261155381540","title":"Dopaminergic signaling and feeding behavior","description":"The top GO terms are dominated by dopaminergic synaptic transmission, eating behavior, and sensitization, which together point to a dopamine-regulated neural signaling cluster involved in reward and feeding regulation. GPCR signaling to cGMP supports a receptor-mediated signaling theme, while other terms such as defense or vascular effects may reflect broader pleiotropy; however, the central pattern centers on dopaminergic neural signaling related to feeding behavior.","confidence":"High","size":18,"edges":17,"triangles":0,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":17},{"id":"GO:0042755","count":17},{"id":"GO:0001963","count":17},{"id":"GO:0007199","count":17},{"id":"GO:1900134","count":17}]},{"hash":"1828099811718719430","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"This cluster is enriched for GO terms related to sensing (sensory perception of pain, visual perception/learning) and dopaminergic synaptic transmission, plus signaling events (ERK cascade, protein phosphorylation) and behavioral responses to cocaine, indicating a neural signaling and sensory processing theme. Some terms (heart development, macrophage chemotaxis) are less central and may reflect pleiotropy.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0071380","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0007507","count":6}]},{"hash":"328870629872989098","title":"Developmental transcriptional regulation and morphogenesis","description":"This cluster shows a mix of transcriptional regulation (positive/negative regulation of RNA Pol II, DNA-templated transcription) alongside broadly developmental processes (angiogenesis, endothelial/smooth muscle cell migration, ECM disassembly, collagen catabolic activity, midbrain development, amelogenesis). The combination suggests a coordinated developmental gene expression program governing morphogenesis across vascular, neural, and extracellular matrix contexts.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0014909","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0035767","count":3},{"id":"GO:0045766","count":3}]},{"hash":"1860511303842113821","title":"Complement and coagulation with ECM remodeling","description":"The top GO terms point to innate immune defense against bacteria and coagulation, with additional collagen/elastin catabolic processes indicating extracellular matrix remodeling. This combination suggests a cluster of proteins involved in host defense linked to tissue remodeling and inflammatory responses, rather than a single narrow function. The pattern is coherent across defense, complement activation (classical and lectin pathways), coagulation, and ECM turnover, supporting a unified theme of immune-coagulation interplay and matrix remodeling during response to Gram-positive bacteria.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":7},{"id":"GO:0007596","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0030574","count":6},{"id":"GO:0001867","count":6}]},{"hash":"880385529774524554","title":"Fungal lipid and sterol metabolism","description":"The strongest signals are lipid- and sterol-focused: ether lipid metabolic process, unsaturated fatty acid biosynthesis, ergosterol biosynthetic regulation, and especially sphingolipid metabolism via mannosyl-inositol phosphorylceramide. While there are some tangential terms (nitric oxide, vitamin A metabolism, mitochondrion inheritance), the dominant theme is fungal lipid/sterol biosynthesis and related pathways, justifying a fungal lipid/sterol cluster label.","confidence":"High","size":18,"edges":22,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0046485","count":3},{"id":"GO:0006636","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0006809","count":2}]},{"hash":"2047410694420834065","title":"Embryonic development and tissue morphogenesis","description":"This cluster aggregates proteins linked to trophoblast and placental differentiation, together with heart cushion EMT, left-right patterning, cartilage morphogenesis, and endocrine organ development, indicating a broad embryonic development/morphogenesis program rather than a single pathway.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0030194","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0060536","count":4}]},{"hash":"922549995471029358","title":"Ubiquitin-dependent immune signaling and NF-kappaB activation","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes and various ubiquitin linkages (K6, K63), including protein autoubiquitination, indicating ubiquitin-mediated regulation of protein turnover. It also features innate immune response and positive regulation of TNF-mediated signaling and canonical NF-kappaB signaling, suggesting a theme of ubiquitin-driven modulation of immune signaling pathways. A minority of terms point to histone catabolism or intracellular transport of viral material, but the prevalent pattern is ubiquitin-based control of immune and signaling processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0051865","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0036205","count":8},{"id":"GO:0085020","count":8}]},{"hash":"1850129171096112196","title":"Immune signaling and barrier development","description":"The top GO terms cluster around immune cell differentiation (B cells, NK T cells), various signaling pathways (Wnt, integrin, LPS-mediated signaling), and barrier establishment (endothelial intestinal barrier), suggesting a functional theme centered on immune signaling with related barrier processes. Some terms are more peripheral (peroxisome import, brood size, adipose development), but the core appears immune-signaling oriented, meriting a concise label that reflects this theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060378","count":3},{"id":"GO:0090557","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0016560","count":3}]},{"hash":"448302477817437894","title":"Dopaminergic GPCR Signaling with Cardiovascular and Immune Regulation","description":"This cluster centers on dopaminergic synaptic transmission and GPCR-cGMP signaling, with additional terms spanning blood pressure regulation, monocyte chemotaxis, coagulation, and defense against bacteria. While dopaminergic signaling is a clear focal point, the presence of cardiovascular and immune\u2013related terms suggests GPCR-mediated regulation across neural, vascular, and immune systems, justifying a label that captures this integrative signaling role.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042742","count":13},{"id":"GO:0007202","count":13},{"id":"GO:0007596","count":13},{"id":"GO:0035815","count":13},{"id":"GO:0090026","count":13}]},{"hash":"1402942519602360296","title":"Receptor Signaling and Endosomal Transport","description":"The top GO terms point to receptor-mediated signaling (cell surface receptor tyrosine kinase signaling, dopamine receptor signaling, TLR2 signaling) and intracellular trafficking (early endosome to Golgi transport). The mix of neural and immune signaling terms, plus a transport term, supports a theme centered on signal initiation at membranes and routing through endosomal compartments.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:0034498","count":2},{"id":"GO:0051770","count":2},{"id":"GO:1902499","count":2},{"id":"GO:0060161","count":2}]},{"hash":"105698359072976778","title":"Dopaminergic GPCR Signaling and Feeding Behavior","description":"The top GO terms converge on dopamine-related neural signaling and GPCR pathways linked to behavior, especially feeding and sensitization, plus dopaminergic synaptic transmission. This suggests a core theme of dopamine-driven neuromodulation involved in reward and eating behavior, with GPCR-cGMP signaling as a common mechanism. Some terms appear broad or peripheral (e.g., defense or heat generation) and may reflect annotation noise, but they do not override the central dopaminergic signaling theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":18},{"id":"GO:0042755","count":18},{"id":"GO:0001963","count":18},{"id":"GO:0007199","count":18},{"id":"GO:1900134","count":18}]},{"hash":"1550099822706928951","title":"Neuronal GPCR Signaling and Dopaminergic Synaptic Transmission","description":"GO terms indicate neuronal GPCR signaling (adenylate cyclase activation, neuropeptide signaling) and dopaminergic synaptic transmission, with ERK1/2 cascade regulation and behavioral/physiological outputs (eating behavior, blood pressure); the electron transport chain hint suggests energy support for neural signaling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0007218","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0070374","count":17},{"id":"GO:0045777","count":17}]},{"hash":"1114304340427219620","title":"Unknown","description":"The top GO terms span several distinct biological areas\u2014blood pressure regulation, GPCR-coupled signaling, cAMP/IP3 signaling, energy production (ETC), inflammatory response, and development across different tissues (lung, kidney, ovary). This broad mix does not reveal a single coherent function tying the proteins together, so a neutral Unknown label with None confidence is appropriate.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0006954","count":12},{"id":"GO:0060427","count":12}]},{"hash":"1763397417011375732","title":"Embryonic development and organ morphogenesis","description":"The proteins are annotated with a spectrum of developmental and morphogenesis GO terms spanning placenta, heart EMT, endocrine system development, cartilage, facial palate, hair follicle morphogenesis, and left-right patterning. This suggests a broad theme of embryogenesis and tissue/organ morphogenesis rather than a single, cohesive pathway. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0035270","count":7}]},{"hash":"1194748792696596946","title":"p53-Dependent DNA Damage-Induced Apoptosis","description":"The dominant GO terms point to intrinsic apoptotic signaling mediated by p53 in response to DNA damage, plus negative regulation of G1/S transition, indicating a core role in p53-driven apoptosis and cell cycle arrest. A few developmental terms appear, but the strongest signal is the p53-mediated apoptotic pathway in response to DNA damage, justifying a label that emphasizes p53-driven apoptosis and checkpoint control.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072332","count":2},{"id":"GO:0008630","count":2},{"id":"GO:2000134","count":2},{"id":"GO:1901223","count":2},{"id":"GO:0097202","count":2}]},{"hash":"81249425085399801","title":"RNA Modification and mRNA Processing","description":"The cluster is dominated by RNA-centric terms: guanine-N7 methylation, mRNA capping, tRNA methylation, mRNA processing, and cytoplasmic translation, indicating roles in RNA maturation and gene expression. Additional terms such as protein ubiquitination and cell cycle may reflect broader regulatory involvement but do not override the RNA-focused theme. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0001300","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0016049","count":2}]},{"hash":"874575544056144372","title":"TLR/NF-kappaB Innate Immune Signaling","description":"The cluster is dominated by GO terms for Toll-like receptor signaling (TLR2, TLR4, TLR9), MyD88-dependent pathways, and positive regulation of canonical NF-kappaB, plus IL-1 signaling, indicating a cohesive innate immune signaling module that activates NF-kappaB and inflammatory responses; a heart development term and a general transport term appear less central to this core theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0070498","count":2}]},{"hash":"805237697467716869","title":"Embryonic Development and Morphogenesis Regulators","description":"This cluster is enriched for DNA-templated transcription and diverse embryonic morphogenesis processes across tissues (heart/outflow tract, eye, pancreas, cranial/skull, bones, habenula). The presence of SMAD signaling points to TGF-beta/BMP-driven developmental regulation, suggesting a core group of transcriptional regulators coordinating embryonic tissue patterning and differentiation.","confidence":"High","size":17,"edges":101,"triangles":298,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0003148","count":6},{"id":"GO:0048048","count":5},{"id":"GO:2000288","count":5},{"id":"GO:0021986","count":5}]},{"hash":"1816368115905826343","title":"Transcription and Cofactor Biosynthesis","description":"This cluster shows strong signals for DNA-templated transcription and cell division, alongside multiple biosynthetic processes for cofactors (heme, protoporphyrinogen IX, cobalamin) and related metabolism, suggesting a coordinated growth and metabolic program centered on transcriptional activity and cofactor production. Confidence: Medium","confidence":"Medium","size":17,"edges":120,"triangles":485,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0051301","count":6},{"id":"GO:0006782","count":6},{"id":"GO:0006783","count":6},{"id":"GO:0009236","count":6}]},{"hash":"1751809244163897177","title":"Neural signaling and synaptic plasticity","description":"The cluster\u2019s top GO terms center on neural function, including sensory perception of sound and long-term synaptic depression, which point to auditory signaling and synaptic plasticity. Supporting terms on Rho signaling, Golgi localization, and myelin-associated protein localization suggest neuronal trafficking and structural dynamics; although some terms relate to immune or vascular processes, the dominant theme appears to be neural signaling and synaptic modulation.","confidence":"Medium","size":17,"edges":94,"triangles":270,"max_degree":15,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0007605","count":13},{"id":"GO:0019933","count":12},{"id":"GO:0090557","count":12},{"id":"GO:0051683","count":12},{"id":"GO:0090179","count":12}]},{"hash":"534557585970848060","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045944","count":16},{"id":"GO:0000398","count":16},{"id":"GO:0048026","count":16},{"id":"GO:0071031","count":15},{"id":"GO:0000390","count":15}]},{"hash":"2066240207577235435","title":"Vesicle Trafficking and Exocytosis","description":"The top GO terms center on vesicular transport through the endomembrane system (endosome-to-lysosome, endosome-to-Golgi, ER-to-Golgi), vacuolar targeting via the CVT pathway, SNARE complex disassembly, and calcium-dependent exocytosis, all pointing to membrane fusion and cargo delivery processes. Sporulation-related assembly terms further support a trafficking/assembly role during fungal development. This coherent theme suggests a cluster specialized for vesicle trafficking and secretion.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008333","count":3},{"id":"GO:0032258","count":3},{"id":"GO:1903078","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0035494","count":3}]},{"hash":"2232479468964008186","title":"Mitochondrial Metabolite Transporters","description":"The top GO terms point to transport of a range of metabolites across mitochondrial and cellular membranes (alpha-ketoglutarate, malate-aspartate shuttle, iron import, glycine and ornithine transport, phosphate, ATP transmembrane transport). This indicates a cohesive theme of mitochondrial metabolite transport and energy exchange, with a secondary signal from broader metabolic processes like fatty acid response. ","confidence":"Medium","size":17,"edges":17,"triangles":2,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":5},{"id":"GO:0035435","count":4},{"id":"GO:0048250","count":3},{"id":"GO:0036233","count":3},{"id":"GO:0000066","count":3}]},{"hash":"705544291236862181","title":"Developmental regulation and organ morphogenesis","description":"This cluster centers on multiple developmental processes across various tissues (eye, brain, cartilage, pituitary, kidney) and includes transcriptional/epigenetic regulation and apoptosis, suggesting a group of genes involved in embryonic development and tissue morphogenesis. A few terms (like lipopolysaccharide response) may reflect broad stress or immune-associated signaling that sometimes intersects development, but the dominant signal is developmental regulation and organogenesis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0051216","count":5},{"id":"GO:0043010","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0000122","count":4}]},{"hash":"1401023474456018550","title":"Immune signaling and transcriptional regulation","description":"This cluster is dominated by terms for adaptive and innate immune responses, along with transcriptional regulation (DNA-templated transcription, RNA polymerase II regulation) and NF-kappaB-related activity, plus a specific note on NLRP3 inflammasome regulation. While a few terms touch on microtubule localization or other processes, the core pattern points to immune signaling intertwined with transcriptional control.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002250","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0035372","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0000122","count":4}]},{"hash":"579487194891106098","title":"Innate and Adaptive Immune Responses","description":"Based on the top GO terms, the cluster centers on immune function: innate and adaptive immune responses, complement activation, Fc-gamma receptor signaling in phagocytosis, defense against bacteria, and regulation of T cell proliferation. The presence of cell adhesion terms can relate to immune cell interactions, but overall immune signaling and defense dominate. An isolated cardiac action potential term likely reflects an annotation artifact rather than a core cluster theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0006508","count":8},{"id":"GO:0007156","count":8},{"id":"GO:0045087","count":7},{"id":"GO:0046007","count":7}]},{"hash":"2124605049255961871","title":"Motor Neuron Axon Guidance and Proprioception","description":"The top terms cluster around motor neuron development and guidance (axonogenesis, axon guidance, lateral motor column migration) and muscle-related signaling (detection of muscle stretch), with supporting cell-adhesion involvement, pointing to a coordinated role in motor neuron pathfinding and neuromuscular innervation. Some terms like gonad development or platelet aggregation appear as broader associations but do not outweigh the central neural and muscle-innervation theme. ","confidence":"High","size":17,"edges":28,"triangles":11,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048936","count":8},{"id":"GO:0007160","count":8},{"id":"GO:0008045","count":8},{"id":"GO:0008585","count":8},{"id":"GO:0070527","count":7}]},{"hash":"2007191335662935422","title":"Complement Activation and B Cell Signaling","description":"The proteins in this cluster are strongly linked to innate immunity (complement activation, defense against Gram-positive bacteria, LPS response, phagocytosis recognition) and adaptive immunity (B cell receptor signaling and B cell activation), suggesting a cohesive module coordinating innate and adaptive immune responses and immune cell interactions.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006958","count":9},{"id":"GO:0050830","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0014068","count":7},{"id":"GO:0007157","count":6}]},{"hash":"667337071661518353","title":"Membrane Transporters for Ions and Nutrients","description":"This cluster is dominated by transmembrane transport GO terms, including sodium ion export and transport of glucose, pantothenate, myo-inositol, biotin, and other nutrients across membranes, indicating a core theme of membrane transporters involved in ion homeostasis and nutrient uptake. A few terms point to mitochondrial assembly processes, suggesting some members may engage in mitochondrial function, but the prevailing signal ties to transport activity across membranes. ","confidence":"Medium","size":17,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071436","count":5},{"id":"GO:0008292","count":5},{"id":"GO:0015887","count":5},{"id":"GO:0015798","count":5},{"id":"GO:0015878","count":5}]},{"hash":"2130766808331279089","title":"Neural development: synapse formation and axon guidance","description":"This cluster concentrates on neuronal connectivity, with strong signals for synapse assembly/organization, myelination, and axon guidance (Roundabout signaling and juxtaparanode localization). It also includes BMP and Rho signaling and ECM remodeling (collagen fibril organization), all consistent with coordinated neural development and maturation of neural circuits.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":10},{"id":"GO:0050808","count":9},{"id":"GO:0042552","count":9},{"id":"GO:0051092","count":8},{"id":"GO:0030199","count":8}]},{"hash":"1955376952235052212","title":"Actin-driven remodeling and immune signaling","description":"This cluster centers on actin cytoskeleton dynamics and related signaling: substrate-dependent cell migration, filopodium assembly, and vesicle transport along actin filaments, plus plasma membrane repair and Rho pathway regulation. Innate immune response and Ras signaling modulation further point to immune-related signaling intertwined with cytoskeletal remodeling, with IP3 biosynthesis contributing to signaling cascades. A few terms (e.g., B cell differentiation) are less tightly connected, so the label is representative but not exclusively definitive.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006930","count":3},{"id":"GO:0051489","count":3},{"id":"GO:0030050","count":3},{"id":"GO:0001778","count":3},{"id":"GO:0002316","count":3}]},{"hash":"381217180625268611","title":"Cytoskeleton remodeling and adhesion signaling","description":"The top GO terms cluster around actin dynamics (stress fiber assembly, dendritic spine development), substrate-adhesion-dependent spreading, and ephrin receptor signaling, pointing to a common theme of cytoskeletal remodeling and membrane signaling in cell\u2013cell and cell\u2013matrix interactions; some mitochondrial and cell-cycle terms are present but appear as peripheral features rather than core to the cluster.","confidence":"Medium","size":17,"edges":17,"triangles":0,"max_degree":15,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0060999","count":4},{"id":"GO:0051496","count":4},{"id":"GO:0055091","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0007006","count":3}]},{"hash":"1994871070381926543","title":"Spliceosome Assembly and Splicing Regulation","description":"This cluster is enriched for GO terms tied to pre-mRNA splicing and spliceosome function (mRNA splice site recognition; regulation of alternative splicing via spliceosome; mRNA cis splicing via spliceosome; small-subunit processome assembly; splicing factor assembly). Although a couple of terms touch on translation initiation or development, the dominant theme is spliceosome-mediated RNA processing, supporting a cohesive group of proteins involved in mRNA splicing and its regulation.","confidence":"High","size":17,"edges":21,"triangles":5,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":3},{"id":"GO:0000381","count":3},{"id":"GO:0045292","count":2},{"id":"GO:0045843","count":2},{"id":"GO:0007399","count":2}]},{"hash":"136141095024595703","title":"Retroviral entry, integration, and latency","description":"This cluster centers on steps of a retroviral life cycle and host interactions: viral entry into the host, reverse transcription (RNA-templated DNA biosynthesis), integration of provirus into the host genome, and establishment of proviral latency. Additional GO terms about transcription initiation, DNA replication, and apoptosis activation reflect host\u2013virus interaction and genome editing/maintenance processes during infection. The cohesive theme is virus-driven genome integration and latent proviral maintenance within host cells.","confidence":"High","size":17,"edges":100,"triangles":277,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042276","count":3},{"id":"GO:0006367","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3}]},{"hash":"2160204948658775138","title":"Nuclear transcriptional and signaling regulators","description":"The cluster is dominated by regulatory GO terms rather than a single pathway: negative regulation of transcription by RNA polymerase II, SMAD signaling regulation, nuclear import (NLS-bearing proteins), cell cycle regulation, and various developmental and apoptotic signaling regulations. This points to proteins that function as nuclear regulators coordinating transcription and signaling, with some developmental roles, rather than a specific metabolic process. ","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:1900006","count":2},{"id":"GO:0007184","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0090526","count":2}]},{"hash":"1689166812533458793","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"This cluster centers on actin polymerization, filopodium/ruffle assembly, and cell spreading, with associated signaling (Rho family GTPases, Ephrin, Wnt) that coordinate endocytosis and membrane dynamics to drive cell movement.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090263","count":11},{"id":"GO:0007264","count":11},{"id":"GO:0043552","count":11},{"id":"GO:0045806","count":11},{"id":"GO:0006897","count":11}]},{"hash":"1683983578880425214","title":"Adhesion signaling in hematopoietic differentiation","description":"This cluster is enriched for ephrin receptor and integrin-mediated signaling as well as pathways involved in blood cell development and immune regulation (erythrocyte differentiation, B cell and monocyte differentiation, GM-CSF production). The combination points to proteins coordinating cell adhesion and signaling that drive hematopoietic/immune cell growth and differentiation, with supporting Wnt pathway involvement. ","confidence":"High","size":17,"edges":56,"triangles":59,"max_degree":11,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0048013","count":17},{"id":"GO:0034446","count":17},{"id":"GO:0045648","count":16},{"id":"GO:0030889","count":16},{"id":"GO:0090263","count":16}]},{"hash":"1797300464225972900","title":"Ubiquitin-Dependent Proteolysis in Innate Immunity","description":"The cluster is enriched for ubiquitination-related processes (mono-, poly-, and K63-linked ubiquitination) and ubiquitin-dependent protein catabolic pathways, including ERAD, alongside innate immune defenses (against Gram-positive bacteria and viruses). This points to a cohesive module where ubiquitin-mediated proteolysis regulates immune signaling and host defense.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0042787","count":5},{"id":"GO:0000209","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0071276","count":4}]},{"hash":"2286812964691522572","title":"Post-transcriptional gene regulation: translation & splicing","description":"The top GO terms cluster around regulation of translation initiation, formation of the translation preinitiation complex, translation reinitiation, IRES-dependent viral translation, and regulation of translational initiation, alongside mRNA splicing regulation (spliceosome-mediated and cis-splicing) and stress-related mRNA stability, plus regulatory ncRNA-mediated gene silencing. This combination strongly suggests a set of proteins involved in post-transcriptional control of gene expression, especially at the levels of translation and RNA processing, with some viral translation context.","confidence":"High","size":17,"edges":24,"triangles":4,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":9},{"id":"GO:0031047","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0048025","count":8},{"id":"GO:0075522","count":8}]},{"hash":"2068020166523803632","title":"Calcium-Dependent Transcription Regulation","description":"The cluster centers on calcium signaling (release of sequestered Ca2+ into the cytosol) and activation of the calcineurin-NFAT pathway, which is tied to transcriptional control (e.g., termination of RNA polymerase II transcription). This suggests a theme of calcium-driven regulation of gene expression and related signaling events; some other terms (lens development, TE silencing) are less clearly connected and may reflect broader or incidental annotations. Overall, a plausible shared function is calcium-dependent transcriptional regulation and signaling influencing cell cycle decisions.","confidence":"Medium","size":17,"edges":22,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0070307","count":2},{"id":"GO:0010526","count":1},{"id":"GO:0070940","count":1},{"id":"GO:0006369","count":1},{"id":"GO:0006378","count":1}]},{"hash":"732868766165269948","title":"Nuclear transcription and RNA processing","description":"These proteins most strongly align with nuclear RNA metabolism: DNA-templated transcription, 7-methylguanosine mRNA capping, and snRNA export from the nucleus are prominent, pointing to roles in transcription and RNA processing/export. The presence of developmental terms (blastocyst development, hair follicle maturation) and signaling-related terms (GTPase regulation, kinase activation, calcium signaling) suggests additional, context-dependent roles, but the core theme appears to be nuclear transcription and RNA processing.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0001824","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0048820","count":2},{"id":"GO:0006370","count":2}]},{"hash":"1035310783038905445","title":"Developmental Signaling and Stress Responses","description":"This cluster shows a mix of neural signaling terms (synaptic transmission, long-term potentiation) and development-related terms (heart, muscle, gonad development) plus stress-related processes (apoptosis, hypoxia, acute-phase response), suggesting a broad developmental signaling theme with stress adaptations rather than a single precise function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0007268","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060291","count":3}]},{"hash":"2154253201876434990","title":"Stress-Induced Apoptosis and Development Regulation","description":"The top GO terms point to cellular stress responses (hypoxia, ER stress\u2013related apoptosis) with neuronal apoptosis, alongside broader processes like chromatin organization, mRNA transport, and development/cell-cycle regulation. This suggests a cluster of proteins involved in stress-induced cell fate decisions that are intertwined with transcriptional/chromatin control and developmental processes, rather than a single narrow pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0071456","count":11},{"id":"GO:0051402","count":10},{"id":"GO:0043547","count":10},{"id":"GO:0031497","count":10},{"id":"GO:0031954","count":10}]},{"hash":"351259053767269124","title":"RNA Cap Methylation","description":"The top GO terms are strongly dominated by RNA (guanine-N7)-methylation and 7-methylguanosine mRNA capping, indicating a core function in mRNA cap formation and processing. The other terms (phagocytosis, xenobiotic response, regeneration, granulocyte chemotaxis, endocytosis) appear less central and may reflect broader annotation or multi-functionality, but the RNA capping signal is the most representative theme of this cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:0006370","count":3},{"id":"GO:0006909","count":2},{"id":"GO:0042418","count":2},{"id":"GO:0042493","count":2}]},{"hash":"1404789133609915342","title":"Host-Virus Interaction and Innate Immune Signaling","description":"The cluster centers on host\u2013virus interplay, including host-mediated activation of viral genome replication and viral protein regulation, along with innate immune pathways such as MyD88-dependent TLR signaling and extrinsic apoptotic signaling. While other terms touch cell cycle and development processes, the strongest cohesive theme is antiviral host response and how viruses modulate host signaling. This makes \"Host-Virus Interaction and Innate Immune Signaling\" a concise, representative label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044829","count":3},{"id":"GO:2001241","count":2},{"id":"GO:1902043","count":2},{"id":"GO:0002755","count":2},{"id":"GO:0006382","count":2}]},{"hash":"974765621588362579","title":"Embryonic Development and Organ Morphogenesis","description":"The top GO terms cluster around embryogenesis, differentiation, and tissue formation (trophoblast giant cell differentiation, EMT in endocardial cushion formation, placenta development, cartilage morphogenesis, left-right patterning), with related organ development terms (endocrine system and pancreatic cell development). Additional terms on mRNA splicing and transcription regulation support developmental gene expression. Overall, the proteins appear linked by roles in embryonic development and organ morphogenesis rather than a single pathway, though there are no direct interaction edges in this dataset.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":9},{"id":"GO:0003198","count":9},{"id":"GO:0060806","count":9},{"id":"GO:0035270","count":9},{"id":"GO:0003323","count":9}]},{"hash":"315915280320037","title":"Neural and Visual System Development","description":"This cluster centers on neural and sensory organ development, with terms for midbrain development, dopaminergic neuron differentiation, motor neuron axon guidance, and camera-type eye development, plus visual perception and anterior/posterior pattern specification. The emphasis on brain regions and eye/visual system formation indicates a coherent neural and visual system development theme, supported by multiple GO terms.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0007601","count":5},{"id":"GO:0043010","count":5},{"id":"GO:0045766","count":5}]},{"hash":"1696239871969444629","title":"Neuronal Development and Synaptic Signaling","description":"The enrichment centers on nervous system development, synaptic transmission (glutamatergic), excitatory postsynaptic potentials, and neural cell adhesion, indicating a neuronal development and synaptic function cluster. A few immune-related terms are present but appear secondary to the neural-focused terms.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000187","count":8},{"id":"GO:0042742","count":6},{"id":"GO:0035249","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0007157","count":6}]},{"hash":"1989664770548148375","title":"Dopaminergic Signaling and Eating Behavior","description":"Based on the top GO terms, the cluster is centered on dopamine-related neuronal signaling and behavior, particularly dopaminergic synaptic transmission and eating behavior, supported by GPCR-cGMP signaling. While there are some more disparate terms (immune defense, heat generation, renin regulation) that may reflect broader contexts or annotation noise, the clearest common thread is dopaminergic signaling tied to feeding/reward processes.","confidence":"Medium","size":17,"edges":13,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":13},{"id":"GO:0042755","count":13},{"id":"GO:0001963","count":13},{"id":"GO:0007199","count":13},{"id":"GO:1900134","count":13}]},{"hash":"1545745605287403486","title":"Inflammation-Linked Coagulation Signaling","description":"The cluster centers on inflammatory responses and coagulation, with strong GO terms for blood coagulation, inflammatory response, prostaglandin E signaling, and LPS response. Calcium mobilization and ERK signaling suggest downstream transcriptional effects tied to these immune-vascular processes, while dopamine receptor signaling and remodeling-related terms hint at broader signaling and tissue-context roles. Overall, these proteins appear to participate in inflammation-driven coagulation and signaling pathways.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":10},{"id":"GO:0071380","count":9},{"id":"GO:0051281","count":9},{"id":"GO:0032496","count":9},{"id":"GO:0008283","count":9}]},{"hash":"270895669180045155","title":"Dopaminergic Neuropeptide Signaling and Locomotion","description":"This cluster is dominated by terms tied to dopamine-mediated signaling, neuropeptide pathways, and GPCR cascades, with behavioral outputs such as locomotion and eating behavior, plus dopaminergic synaptic transmission and ERK signaling. The shared theme suggests a coherent dopaminergic neuromodulatory module that regulates movement and feeding through GPCR and downstream ERK pathways.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007218","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0007626","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0046960","count":12}]},{"hash":"983749486353961801","title":"Embryonic morphogenesis and organ development","description":"Primarily features embryonic development and tissue morphogenesis. The top terms cover placental/trophoblast differentiation, EMT in heart development, and morphogenesis across multiple tissues (cartilage, hair follicles, palate), plus axis patterning, indicating a cohesive theme of embryonic tissue formation rather than a single tissue type.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":16},{"id":"GO:0003198","count":16},{"id":"GO:0060806","count":16},{"id":"GO:0003323","count":16},{"id":"GO:0035270","count":16}]},{"hash":"903515724724838832","title":"Ubiquitin-Dependent Proteolysis and Innate Antiviral Defense","description":"This cluster is driven by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, protein polyubiquitination, and the ERAD pathway, indicating a focus on ubiquitin\u2011mediated proteolysis. The presence of autophagy and innate immune response terms, along with antiviral-related terms (suppression of viral release, transport of viral material), suggests an overarching role in antiviral defense. Additional terms on circadian regulation and vitamin D response may reflect immune modulation by these signals, reinforcing the immune/defense theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0000209","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0042752","count":7},{"id":"GO:0033280","count":6}]},{"hash":"1830537187713828032","title":"Ubiquitin-regulated NF-kappaB/JNK signaling","description":"This cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, various forms of ubiquitination) and signaling pathways including NF-kappaB activation, JNK cascade regulation, and TNF signaling, with additional hints of histone turnover and immune-related recombination. The common theme ties substrate ubiquitination to modulation of inflammatory signaling, making this label representative and specific.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:1903762","count":8},{"id":"GO:1901253","count":8},{"id":"GO:0033151","count":8},{"id":"GO:0051865","count":8}]},{"hash":"609859850060466832","title":"Developmental growth and stress responses","description":"The top GO terms point to proliferation, development, and cell division, suggesting a growth and developmental program. Coupled with RNA processing, transcription, and ribosome biogenesis, the cluster also encompasses gene expression and protein synthesis machinery. The presence of ER stress\u2013related apoptosis signaling, ubiquitin-dependent ERAD, actin nucleation, and hypoxia response indicates concurrent cellular stress adaptation and cytoskeletal remodeling, all tying into developmental growth with stress responsiveness.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008284","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0042273","count":4}]},{"hash":"412806589679758326","title":"TLR-NF-kB innate immune signaling","description":"This cluster centers on Toll-like receptor signaling (TLR2/4), canonical NF-kB activation, and innate immune response, with related processes like xenophagy. While there is a note of Rho signaling and splicing regulation, the dominant theme is TLR-driven NF-kB\u2013mediated innate immunity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:1904417","count":2},{"id":"GO:0034134","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0034142","count":2}]},{"hash":"820261886433707957","title":"Development and Cytoskeleton Dynamics","description":"These proteins show a pattern centered on developmental processes (multicellular organism development, neuron projection development) with signs of cytoskeletal remodeling (cilium assembly, barbed-end actin filament capping) and regulatory roles for GTPases, suggesting coordinated growth and morphogenesis tied to the cytoskeleton. A viral mRNA export term appears incidental and does not align with the main theme. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0097050","count":3},{"id":"GO:0000920","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0051260","count":3}]},{"hash":"1937878463674155086","title":"Unknown","description":"The GO terms span immune signaling, vascular and neural development, chromatin modification, ubiquitination, stress response, and fundamental cell cycle and transcription processes, with no single unifying function evident. The diversity suggests no coherent cluster theme can be confidently assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050731","count":2},{"id":"GO:0042102","count":2},{"id":"GO:0048845","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0016575","count":2}]},{"hash":"550426116766888768","title":"Negative Regulation of Signaling Pathways","description":"The top GO terms show repeated emphasis on inhibiting signaling cascades (ERK/MAPK, T cell receptor, PI3K/AKT, focal adhesions) across contexts, plus related neuronal and immune signaling regulation. While a couple terms touch on positive regulation in other processes, the prevailing pattern is suppression of signaling, suggesting the cluster comprises proteins that dampen signal transduction.","confidence":"High","size":16,"edges":117,"triangles":519,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":13},{"id":"GO:0070373","count":13},{"id":"GO:0050860","count":13},{"id":"GO:2000808","count":10},{"id":"GO:0097107","count":10}]},{"hash":"2042204213305018821","title":"Metabolic Transport and Stress Response","description":"This cluster shows a convergence on metabolic biosynthesis (GMP biosynthesis; L-cysteine biosynthesis/transsulfuration), amino acid\u2013related pathways, and transport (magnesium ion transmembrane transport; glycine betaine transport), plus a cellular response to glucose starvation and activation of protein kinase activity, indicating a core theme of metabolism, transport, and nutrient-stress signaling. The retina development and innate immune/defense terms are likely less representative outliers or annotation noise. Overall, it points to metabolism plus stress-response functions rather than a single specific pathway. ","confidence":"Medium","size":16,"edges":46,"triangles":63,"max_degree":14,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0060041","count":7},{"id":"GO:0045087","count":5},{"id":"GO:0050830","count":5},{"id":"GO:1903830","count":5},{"id":"GO:0019343","count":5}]},{"hash":"3621797964898597","title":"Mitochondrial Redox Homeostasis and Apoptosis","description":"This cluster centers on mitochondrial redox control, ROS detoxification, and cytochrome c\u2013driven apoptosis. Key terms include redox homeostasis, oxidant detoxification, mitochondrial electron transport, cytochrome c linkage, and apoptotic process, with related hints at hydrogen peroxide regulation and signal transduction. Together they point to a theme of mitochondrial redox balance governing survival versus apoptosis.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0045454","count":8},{"id":"GO:0043535","count":8},{"id":"GO:0098869","count":6},{"id":"GO:0055114","count":4},{"id":"GO:0006915","count":3}]},{"hash":"714335505396983747","title":"Embryonic development and organ morphogenesis","description":"These proteins are linked to a range of embryonic development and organ morphogenesis processes across diverse tissues (heart, brain, pituitary, eye, placenta, limb, gonads, prostate). The common theme is embryonic morphogenesis and organ formation, suggesting a broad developmental regulatory role rather than a single tissue-specific function.","confidence":"High","size":16,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003148","count":7},{"id":"GO:0021986","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0001701","count":6},{"id":"GO:0048048","count":6}]},{"hash":"1952270150611107873","title":"Neuronal proteostasis and metal stress response","description":"The dominant GO terms cluster around ubiquitin-proteasome\u2013mediated protein degradation (ubiquitin-dependent catabolic process, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein polyubiquitination) and cellular responses to heavy metals (methylmercury, cadmium, arsenic) with oxidative stress\u2013related apoptotic signaling and a neuronal hint from synapse assembly. This suggests a cohesive theme of proteostasis machinery engaged in neuronal stress conditions, despite a few outlier cell-cycle terms. ","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:1903378","count":10},{"id":"GO:0031146","count":10},{"id":"GO:0000083","count":9},{"id":"GO:0000209","count":9}]},{"hash":"729682439054648703","title":"Synaptic vesicle trafficking and endosome transport","description":"This cluster is dominated by GO terms related to vesicle cycling and trafficking in neurons: regulation of synaptic vesicle endocytosis, vesicle docking in exocytosis, endosome-to-lysosome transport, and retrograde transport from endosomes to the Golgi, plus dendrite morphogenesis. The convergence on intracellular transport of vesicles and organelles suggests a functional theme around synaptic vesicle recycling and endosomal sorting in neurons. Some outliers (regulation of T cell activation, nitrogen starvation arrest) may reflect broader roles of the proteins or annotation noise, but they do not override the strong vesicle-trafficking signal.","confidence":"High","size":16,"edges":9,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":16},{"id":"GO:0006904","count":16},{"id":"GO:0048813","count":16},{"id":"GO:0010963","count":16},{"id":"GO:0071851","count":16}]},{"hash":"1140713751757224823","title":"Synaptic Vesicle Trafficking and Endosomal Transport","description":"The cluster is dominated by GO terms related to vesicle dynamics and trafficking (synaptic vesicle endocytosis, vesicle docking in exocytosis, endosome to lysosome transport, retrograde transport to Golgi, intracellular protein transport) and neuron-related development (dendrite morphogenesis). This points to a cohesive module centered on vesicle cycling and endosomal pathways in neural contexts, with some parallel regulation of membrane transport processes and dendritic structure.","confidence":"High","size":16,"edges":67,"triangles":141,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":16},{"id":"GO:0006904","count":16},{"id":"GO:0048813","count":16},{"id":"GO:0010963","count":16},{"id":"GO:0071851","count":16}]},{"hash":"2057282659646690836","title":"Developmental differentiation regulators","description":"This cluster\u2019s top GO terms point to development and differentiation across multiple tissues (heart, mesenchyme, muscle lineages, plant stomata, reproductive tissues) along with general transcriptional regulation, suggesting proteins that broadly regulate developmental processes rather than a single pathway.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":15},{"id":"GO:0045668","count":15},{"id":"GO:0060921","count":13},{"id":"GO:0010374","count":13},{"id":"GO:0035481","count":13}]},{"hash":"211667163006221171","title":"Cerebellar neurodevelopment and growth signaling","description":"In this cluster, the strongest neural-development terms dominate (cerebellar cortex formation; Bergmann glial differentiation; regulation of axon regeneration), with accompanying growth/metabolic signals (insulin receptor signaling, glucose transport). The presence of cell-cycle and kinetochore-related terms suggests coordinated proliferation regulation during development. While some immune-related signaling appears, the neural-development and growth-related terms are the most prominent, justifying this label.","confidence":"Medium","size":16,"edges":112,"triangles":465,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":16},{"id":"GO:2001275","count":16},{"id":"GO:0060020","count":16},{"id":"GO:0045736","count":16},{"id":"GO:0000082","count":16}]},{"hash":"1137096925239874488","title":"Redox Homeostasis and ER Protein Quality Control","description":"The top GO terms cluster around redox balance, oxidative stress response, and detoxification, with notable links to ER-based protein folding and repair. This suggests a cohesive theme of maintaining proteome integrity under oxidative stress through redox regulation and ER quality control mechanisms.","confidence":"High","size":16,"edges":49,"triangles":68,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":12},{"id":"GO:0055114","count":11},{"id":"GO:0098869","count":10},{"id":"GO:0034975","count":8},{"id":"GO:0080058","count":8}]},{"hash":"1901705390924561240","title":"Unknown","description":"The top GO terms are highly heterogeneous: neurogenesis, development (vagina development), apoptotic process, lipid and phospholipid homeostasis, immune response (response to virus, cellular response to lipopolysaccharide), and gene expression regulation. There is no single dominant functional theme that ties the proteins together, so a specific, representative label cannot be justified. Therefore the cluster is best described as Unknown with no confidence.","confidence":"","size":16,"edges":96,"triangles":305,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":6},{"id":"GO:0008284","count":6},{"id":"GO:0060068","count":6},{"id":"GO:0006915","count":6},{"id":"GO:0042632","count":5}]},{"hash":"1831180753438477462","title":"mRNA Splicing and Translation Initiation","description":"The dominant GO terms cluster around spliceosome-mediated mRNA processing (splicing via spliceosome, splice site recognition, regulation/alternative splicing, small-subunit processome assembly) and the assembly of translation initiation machinery (preinitiation complex formation, eIF4F complex assembly). There\u2019s also regulation of mRNA stability under stress, suggesting coordination between RNA processing and translation during stress. This points to a cohesive group of proteins involved in mRNA maturation, splicing control, and initiation of translation.","confidence":"High","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":12},{"id":"GO:0045292","count":11},{"id":"GO:0006378","count":11},{"id":"GO:0000381","count":11},{"id":"GO:0034462","count":10}]},{"hash":"1103502787287090491","title":"Neuronal amino acid transport and GABA synthesis","description":"Several top GO terms indicate import/export of amino acids (threonine, serine, glutamate, D-aspartate) and GABA biosynthesis, all centered on transmembrane amino acid transport in neural cells. While additional brain signaling terms appear, the dominant theme is amino acid transport relevant to neurotransmitter production, especially GABA. This makes the label a concise summary of the cluster\u2019s core function.","confidence":"High","size":16,"edges":110,"triangles":434,"max_degree":15,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0015826","count":7},{"id":"GO:0070779","count":7},{"id":"GO:0009449","count":7},{"id":"GO:0055085","count":7},{"id":"GO:0051938","count":7}]},{"hash":"1937712777491498581","title":"Developmental adhesion and morphogenesis signaling","description":"This cluster centers on cell adhesion and tissue development, with prominent terms for heterophilic and matrix adhesion alongside limb morphogenesis, kidney loop of Henle development, and bone ossification. The inclusion of Notch signaling regulation and hyaluronan synthesis suggests coordinated signaling and extracellular matrix dynamics during development, while entries for radial glial division and gamma-delta T cell differentiation reflect broader neural and immune developmental processes. Overall, the shared theme is developmental adhesion-mediated morphogenesis and signaling.","confidence":"Medium","size":16,"edges":8,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0007160","count":14},{"id":"GO:0045747","count":13},{"id":"GO:0072070","count":13},{"id":"GO:0036363","count":13}]},{"hash":"903184762534187550","title":"Unknown","description":"Top GO terms are diverse (integrin signaling, cell motility, lysosome localization, microglia and retina vascular development, NF-kappaB signaling), with no single cohesive function tying the proteins together, so there is no clear theme to label; thus Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":4},{"id":"GO:2000145","count":3},{"id":"GO:2000680","count":3},{"id":"GO:1904352","count":3},{"id":"GO:0043128","count":3}]},{"hash":"678763412042852685","title":"Developmental Differentiation and Organogenesis","description":"This cluster links broad developmental programs across multiple tissues (heart, lung, neural tube floor plate, retina, plant stomata) with transcription by RNA polymerase II, indicating a general organogenesis/differentiation theme rather than a single pathway.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0060426","count":10},{"id":"GO:0033504","count":10},{"id":"GO:0001756","count":10},{"id":"GO:0035881","count":10}]},{"hash":"741503989316945255","title":"Bacterial energy metabolism and antibiotic biosynthesis","description":"The cluster centers on core metabolic pathways (TCA cycle, 2-oxoglutarate metabolism) and biosynthetic capabilities (polyhydroxybutyrate, methyl-branched fatty acids), along with antibiotic biosynthesis and response. Sporulation and propylene catabolism support a bacterial lifestyle geared toward energy management and secondary metabolite production. Minor outliers (Notch signaling, kynurenine catabolism) do not overturn the overall theme.","confidence":"Medium","size":16,"edges":86,"triangles":291,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":5},{"id":"GO:0017000","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0006103","count":3},{"id":"GO:1902321","count":2}]},{"hash":"1454688299093007640","title":"Neuronal signaling and vesicle trafficking","description":"The top terms cluster around signaling pathways (Wnt signalosome assembly; dopamine receptor signaling; modulation of postsynaptic potentials) and intracellular transport processes (ER\u2013Golgi transport; endosome-to-Golgi retrograde transport). Together they suggest proteins that coordinate cargo trafficking with signaling events in neural contexts and development, even though one term (mitotic spindle assembly) is less directly related. ","confidence":"Medium","size":16,"edges":15,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:1905279","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0090394","count":3},{"id":"GO:0035564","count":3}]},{"hash":"376475158136809518","title":"Bacterial photosynthesis and pigment biosynthesis","description":"This cluster is marked by terms related to photosynthesis (dark reactions, bacteriochlorophyll biosynthesis) and associated pigment and energy metabolism (nitrogen fixation, cobalamin biosynthesis, electron transport), with supporting ribosome/translation terms. The combination suggests a module tied to photosynthetic bacteria and their pigment biosynthesis pathways, rather than a general eukaryotic process. ","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0007059","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0006123","count":2},{"id":"GO:0036070","count":1}]},{"hash":"163113817402700982","title":"Mitotic cell cycle and vesicle trafficking","description":"The top terms are dominated by mitosis and cell division (mitotic cell cycle, cell division), indicating a core role in cell cycle progression. Several endosomal/lysosomal transport terms (endosome-to-Golgi/lysosome, early-to-late endosome) and related trafficking pathways suggest accompanying intracellular transport roles, pointing to proteins with dual roles in division-related processes and vesicle trafficking.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0051496","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0009958","count":3}]},{"hash":"835972701289691047","title":"Regulated signaling and exocytosis in neurons and muscle","description":"The top GO terms cluster around regulation of signaling pathways (Rho, Ras, PI3K/AKT), responses to mechanical stimuli, and vesicle-related processes (synaptic vesicle priming, acrosome reaction, neutrophil degranulation). This suggests a unifying theme of controlled signal transduction coupled with vesicle trafficking and secretion across neuronal, immune, and muscle contexts.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0043314","count":3}]},{"hash":"752107488407298392","title":"Rho GTPase signaling and lamellipodium-driven migration","description":"The cluster is dominated by GO terms for small GTPase signaling, Rho pathway regulation, and lamellipodium assembly, all pointing to actin cytoskeleton remodeling and cell migration. Development-related terms (thymus and parathyroid development, anterior/posterior patterning) suggest involvement in morphogenesis, where these cytoskeletal dynamics drive tissue patterning and organogenesis. Overall, the core theme is Rho GTPase\u2013mediated cytoskeletal remodeling and migration, with developmental roles.","confidence":"Medium","size":16,"edges":16,"triangles":1,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007264","count":15},{"id":"GO:0043552","count":15},{"id":"GO:0035023","count":15},{"id":"GO:1902237","count":15},{"id":"GO:2000251","count":15}]},{"hash":"2125330532483259168","title":"Mitochondrial Membrane Permeabilization and Apoptosis","description":"Based on the top GO terms, the cluster is strongly enriched for mitochondrial outer membrane permeabilization and regulation of mitochondrial membrane permeability in apoptotic processes, along with the general apoptotic process term. While a few developmental terms appear (placenta development, parturition, segmentation) they seem ancillary to the primary mitochondria-linked apoptosis theme, so the core function is mitochondria-driven apoptosis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097345","count":7},{"id":"GO:0001893","count":7},{"id":"GO:0060137","count":7},{"id":"GO:1903547","count":7},{"id":"GO:0015074","count":3}]},{"hash":"433124957404042861","title":"Embryonic organ morphogenesis and tissue branching","description":"These GO terms collectively point to developmental processes across multiple organs: eye and pancreas morphogenesis, gonad development, neural crest migration, and epithelial/tissue branching in lung and ureteric bud. The combination of organ-specific morphogenesis terms with overarching transcription regulation implies a gene cluster involved in embryonic patterning and morphogenesis, hence this label. ","confidence":"High","size":16,"edges":82,"triangles":172,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0031018","count":10},{"id":"GO:0048048","count":9},{"id":"GO:0043010","count":9},{"id":"GO:0008584","count":9}]},{"hash":"28800507417976367","title":"Neural development and synapse formation","description":"The top GO terms focus on neural development and synaptic processes (axonal fasciculation, myelination, and positive regulation of synapse assembly) with an additional otolith morphogenesis term, suggesting a nervous system development theme. The presence of innate immune response and placenta-related terms seems tangential or noisy, but the neural-development signals dominate the cluster\u2019s functional signature.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0032474","count":2}]},{"hash":"1869452124024099353","title":"Chromatin Regulation and Nucleosome Assembly","description":"This cluster is dominated by GO terms related to chromatin state and transcription control: rDNA heterochromatin formation, nucleosome assembly, histone methylation/demethylation, and negative regulation of transcription by RNA Pol II. Presence of ubiquitin-dependent degradation terms suggests regulation of chromatin modifiers. Together these imply a cohesive role in chromatin remodeling and transcriptional regulation.","confidence":"High","size":16,"edges":19,"triangles":2,"max_degree":14,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000183","count":3},{"id":"GO:0051572","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0061086","count":3},{"id":"GO:0006310","count":3}]},{"hash":"1721774053934333862","title":"RNA processing and ER-Golgi trafficking","description":"This cluster is enriched for RNA-centric processes (mRNA splicing via spliceosome, mRNA transport, ribosome biogenesis) alongside vesicle transport between the ER and Golgi (anterograde and retrograde), and related regulatory processes (GTPase activity, serine dephosphorylation, TORC1 signaling, mitotic cell cycle). Together, these terms suggest a theme where gene-expression/processing machinery is coordinated with the secretory pathway and growth-related signaling, justifying a label that highlights both RNA processing and ER-Golgi trafficking. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0070262","count":4},{"id":"GO:0051028","count":4}]},{"hash":"254784174040863377","title":"Genome integrity and telomere/mitotic maintenance","description":"This cluster centers on genome stability: mitochondrial DNA repair, spindle assembly, and positive regulation of telomere maintenance via telomerase, plus protein localization to chromosome telomeric regions. These terms point to chromosome/chromosome-end maintenance and mitotic machinery as core themes, with some stress-response terms (dsRNA, amyloid-beta) likely reflecting cellular responses to genomic stress rather than defining the function. Overall, the dominant signal ties to genome integrity and mitotic apparatus.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":2},{"id":"GO:0090263","count":1},{"id":"GO:0008209","count":1},{"id":"GO:0043504","count":1},{"id":"GO:0051225","count":1}]},{"hash":"934989182699693544","title":"Transmembrane Solute Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of diverse solutes\u2014glucose, xylose, trehalose, sodium ions, organic cations, and even microcystin\u2014indicating a group of membrane transport proteins with multiple substrates. A few terms (e.g., replicative senescence regulation) appear unrelated and may be noise. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":4},{"id":"GO:0015753","count":3},{"id":"GO:0070715","count":3},{"id":"GO:0042891","count":3},{"id":"GO:1905431","count":3}]},{"hash":"2108294685239935779","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms tied to translation (cytoplasmic and general translation) and ribosome biogenesis (including large subunit biogenesis), plus initiation/termination of translation. This points to proteins involved in ribosome assembly and the protein synthesis machinery; a few transcription/division terms appear ancillary rather than central. Confidence: High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0010032","count":3},{"id":"GO:0006351","count":3}]},{"hash":"763857139674809079","title":"Adaptive and Innate Immune Activation","description":"These proteins show strong enrichment for both adaptive immunity (B cell receptor signaling, T cell costimulation, positive regulation of B cell activation) and innate defense (phagocytosis, complement activation, defense against bacterium) along with cell\u2013cell adhesion terms, suggesting a coordinated immune activation network that bridges B/T cell signaling and phagocytic defense.","confidence":"High","size":16,"edges":35,"triangles":9,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050853","count":12},{"id":"GO:0031295","count":12},{"id":"GO:0006911","count":12},{"id":"GO:0007157","count":11},{"id":"GO:0045087","count":11}]},{"hash":"377374713389535346","title":"Lipid transport and vascular development","description":"Top GO terms point to lipid handling (lipoprotein transport, cholesterol storage, foam cell differentiation) together with endothelial growth (endothelial cell proliferation, sprouting angiogenesis) and ECM remodeling (collagen fibril organization). The presence of innate immune response and zymogen activation suggests proteolytic remodeling within this lipid- and vessel-focused program. This combination supports a coherent theme of lipid metabolism linked to vascular development and tissue remodeling.","confidence":"Medium","size":16,"edges":18,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010744","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0031638","count":3},{"id":"GO:0042953","count":3},{"id":"GO:0010886","count":3}]},{"hash":"1236849241711325356","title":"Multitissue Development and Differentiation","description":"This cluster's top GO terms span diverse tissue-specific developmental processes (inner ear, uterus, osteoblasts, ureteric bud, pharyngeal system, male gonad, forebrain neurons, pancreatic cells) and include transcriptional regulation by RNA Pol II, suggesting a broad role in developmental programs and cell fate decisions across multiple tissues rather than a single pathway.","confidence":"Medium","size":16,"edges":84,"triangles":196,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042472","count":8},{"id":"GO:0060065","count":8},{"id":"GO:0002076","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0000122","count":8}]},{"hash":"754476558106626157","title":"Neuropeptide signaling in appetite regulation","description":"The terms show neuropeptide signaling, appetite and eating behavior, and dopaminergic synaptic transmission, plus GPCR/cGMP signaling, indicating a cohesive theme of neuroendocrine control of feeding. While there are also terms related to inflammation and thermogenesis, the dominant pattern centers on neuropeptide-mediated signaling that modulates appetite and dopaminergic pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007218","count":5},{"id":"GO:0032100","count":5},{"id":"GO:0050728","count":5},{"id":"GO:0046960","count":4},{"id":"GO:0042755","count":4}]},{"hash":"443652902061391068","title":"Ubiquitin-Dependent Immunity and Proteolysis","description":"The top GO terms are dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process and protein ubiquitination), suggesting a central role in ubiquitin-proteasome\u2013driven protein turnover. Additionally, innate immune response, defense response to virus, and NF-kappaB-related regulation point to antiviral and immune signaling functions, with V(D)J recombination indicating connections to adaptive immunity. A vitamin D response term adds an immunomodulatory angle. Overall, this cluster seems to group proteins involved in ubiquitin-mediated proteolysis that modulate immune and antiviral responses.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0016567","count":10},{"id":"GO:0033280","count":9},{"id":"GO:0051092","count":9},{"id":"GO:0045087","count":9}]},{"hash":"136037636654441371","title":"Dopaminergic Signaling and Eating Behavior","description":"The top GO terms highlight dopaminergic synaptic transmission (GO:0001963), eating behavior (GO:0042755), and GPCR signaling linked to a cGMP second messenger (GO:0007199), pointing to dopamine-driven neural circuits regulating reward and appetite. This core theme is complemented by related signaling and regulatory processes, with a few outlier terms (defense response, vascular permeability, heat generation) that may reflect pleiotropic GPCR roles or annotation noise. Overall, the cluster appears centered on dopaminergic neurotransmission and feeding-related signaling.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":16},{"id":"GO:0042755","count":16},{"id":"GO:0001963","count":16},{"id":"GO:0007199","count":16},{"id":"GO:1900134","count":16}]},{"hash":"955776650680369650","title":"NF-kappaB signaling and ubiquitination regulation","description":"This cluster is driven by GO terms central to NF-kappaB pathway regulation (I-kappaB phosphorylation, canonical NF-kappaB signaling) and ubiquitination, with additional signals about GTPase activity and kinase regulation, suggesting a coherent theme of transcriptional signaling control and protein modification. Some terms like axonogenesis and male gonad development may reflect broader annotation links or noise rather than a distinct alternate function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0016567","count":3},{"id":"GO:0007190","count":3},{"id":"GO:0007252","count":3},{"id":"GO:0008584","count":3}]},{"hash":"534644897382144355","title":"Chemokine signaling and leukocyte chemotaxis","description":"Enriched for chemokine-mediated signaling and chemotaxis of monocytes, macrophages, and eosinophils, indicating a cohesive immune cell recruitment theme. The presence of neuropeptide signaling and insulin secretion regulation suggests a broader neuroimmune/metabolic signaling context, but the dominant pattern is chemokine-directed leukocyte movement.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007218","count":6},{"id":"GO:0030168","count":6},{"id":"GO:0050796","count":6},{"id":"GO:0006955","count":6},{"id":"GO:0048245","count":6}]},{"hash":"1240241153249979882","title":"Vertebrate organogenesis and morphogenesis","description":"The top GO terms point to diverse vertebrate developmental processes\u2014heart development (ventricular cardiac muscle cell development, endocardial cushion development/fusion), craniofacial morphogenesis (face morphogenesis, neural crest migration, eyelid development), thymic immune regulation, adipose differentiation, and trachea formation\u2014along with ERK signaling modulation. This pattern suggests a cluster of proteins involved in general organogenesis and tissue morphogenesis rather than a single specialized function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055015","count":3},{"id":"GO:0060325","count":3},{"id":"GO:0033088","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0001755","count":2}]},{"hash":"679785530751403670","title":"Glycinergic Synaptic Transmission and Transport","description":"The cluster is dominated by terms related to glycinergic synaptic signaling, including glycine import, glycinergic neurotransmission, and related transporter activities, with supporting references to dopamine uptake and serotonin secretion in neural contexts, plus brain-development terms (thalamus, adenohypophysis). This points to a coherent theme of glycine-mediated synaptic transmission and associated transport processes in the brain.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021984","count":5},{"id":"GO:0036233","count":5},{"id":"GO:1905847","count":5},{"id":"GO:0014064","count":5},{"id":"GO:0060092","count":5}]},{"hash":"564929981245288862","title":"Unknown","description":"The GO terms span a wide range of processes (vitamin D response, ubiquitin-dependent protein degradation, telomere maintenance, telomeric localization, cardiac signaling, NF-kappaB regulation, membrane depolarization in cardiac cells, epithelial polarity, actin assembly, and adipocyte differentiation), with no clear single function tying the proteins together. Added to the lack of edges, this suggests there is no coherent common theme for this cluster.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0032212","count":3},{"id":"GO:0070198","count":3},{"id":"GO:0086070","count":3}]},{"hash":"538236472051529817","title":"Placental and Embryonic Development","description":"The top GO terms cluster around trophoblast giant cell differentiation, EMT in placental and cardiac contexts, endocrine and pancreatic development, cartilage formation, and left-right patterning, with supporting roles in transcription and RNA processing. Together they indicate a developmental program centered on embryogenesis and placental lineage specification, rather than a single enzymatic or signaling pathway.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":16},{"id":"GO:0003198","count":16},{"id":"GO:0060806","count":16},{"id":"GO:0035270","count":16},{"id":"GO:0003323","count":16}]},{"hash":"242015089663635949","title":"GTPase-Driven Cytoskeleton and Junction Regulation","description":"The Top Terms cluster centers on regulation of GTPase activity and small GTPase\u2013mediated signaling, actin filament organization and filopodium assembly, and processes related to cell junctions and membranes (tight junctions, caveolae) as well as endocytosis. This suggests a coherent theme of cytoskeletal remodeling coordinated with cell\u2013cell and membrane trafficking functions, driven by GTPase signaling, which is well captured by a label focusing on cytoskeleton dynamics and junction regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0051489","count":3},{"id":"GO:0043114","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0060313","count":3}]},{"hash":"326200995132712530","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":14,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0046328","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0060669","count":2},{"id":"GO:0070562","count":2},{"id":"GO:0045869","count":2}]},{"hash":"2107234332245020648","title":"Rho GTPase\u2013driven vesicle signaling in neural development","description":"The top GO terms center on positive regulation of GTPase activity and Rho protein signaling, combined with vesicle fusion and calcium-dependent exocytosis, all of which are key processes in neuronal development and synaptic vesicle trafficking. Brain and nervous system development terms further support a neural development theme, suggesting these proteins coordinate signaling and exocytosis during neural maturation. Some terms appear non-neural or noisy (e.g., ABA signaling, pseudohyphal growth), but the dominant pattern points to Rho/GTPase-regulated vesicle trafficking in neurons.","confidence":"High","size":15,"edges":76,"triangles":200,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":12},{"id":"GO:0001501","count":12},{"id":"GO:0007420","count":12},{"id":"GO:0007399","count":11},{"id":"GO:0006906","count":11}]},{"hash":"1913062180572931084","title":"Developmental Signaling and Calcium Exocytosis","description":"The GO terms center on development across nervous, skeletal, and heart tissues, with a notable emphasis on calcium-dependent exocytosis and Rho signaling that coordinate cell communication and morphogenesis; peripheral terms reflect broader cellular responses, but the core theme points to multisystem developmental regulation and vesicle release in signaling.","confidence":"Medium","size":15,"edges":96,"triangles":349,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007399","count":11},{"id":"GO:0045956","count":11},{"id":"GO:0007266","count":11},{"id":"GO:0001501","count":11},{"id":"GO:0007124","count":11}]},{"hash":"2216330239981795118","title":"Embryonic organ morphogenesis","description":"The top GO terms point to broad embryonic development and organ formation across multiple tissues (neural crest migration, heart and eye development, pancreas and digestive tract morphogenesis, placenta, and ureteric branching), indicating a cohesive theme of embryonic organ morphogenesis. A single transcription regulation term may reflect regulatory control within these developmental processes, supporting the overall developmental cluster concept.","confidence":"Medium","size":15,"edges":50,"triangles":34,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001755","count":9},{"id":"GO:0031018","count":9},{"id":"GO:0090190","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0048557","count":9}]},{"hash":"1074729113732640396","title":"Diverse biosynthetic and pigment metabolism","description":"These proteins appear to participate in a range of biosynthetic and metabolic processes, including steroid (androgen, testosterone) biosynthesis, lipid/sphinganine metabolism, vitamin and pigment biosynthesis (melanin, retinal, tetrahydrobiopterin), and related developmental contexts. The common thread is broad biosynthetic/metabolic activity across diverse substrates rather than a single cohesive pathway, hence a label focused on \u201cdiverse biosynthesis and pigment metabolism.\u201d ","confidence":"Medium","size":15,"edges":19,"triangles":6,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":11},{"id":"GO:0061370","count":11},{"id":"GO:0006666","count":10},{"id":"GO:0042376","count":10},{"id":"GO:0017000","count":10}]},{"hash":"1475278101054172750","title":"Tissue Morphogenesis and ECM","description":"This cluster combines GO terms related to morphogenesis across multiple tissues (skin, eye, tendon, kidney basement membrane) and ECM-related processes (integrin biosynthesis, basement membrane development, protein interactions), suggesting a cohesive theme around tissue formation and extracellular matrix interactions rather than a single specific pathway.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043589","count":5},{"id":"GO:0071230","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0048593","count":4},{"id":"GO:0045112","count":3}]},{"hash":"535444782135072539","title":"Redox Stress Response and Respiration","description":"Top GO terms cluster around oxidative stress and redox chemistry (oxidation-reduction process, cellular response to hydrogen peroxide) alongside energy metabolism (aerobic respiration, proton transmembrane transport) and signaling (protein autophosphorylation). This suggests a module centered on maintaining redox balance during respiration and energy production, with some auxiliary terms related to protein assembly and regulation. Given the mix of core redox/respiration terms and some peripheral processes, the label captures the primary theme but may not be perfect for all members of the cluster.","confidence":"Medium","size":15,"edges":86,"triangles":266,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0070301","count":5},{"id":"GO:1902600","count":4},{"id":"GO:0009060","count":3},{"id":"GO:0001516","count":3}]},{"hash":"1827505098694721136","title":"Lipid and sterol biosynthesis with membrane trafficking","description":"This cluster is dominated by GO terms tied to lipid metabolism and membrane biogenesis, including unsaturated fatty acid biosynthesis, sphingolipid (MIPC) metabolism, and ergosterol biosynthesis regulation, plus a term on ER exit which points to membrane trafficking. While there are a few outliers (nitric oxide and CNS-related terms), the core theme centers on lipid/sterol production and membrane-associated processes.","confidence":"Medium","size":15,"edges":21,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":4},{"id":"GO:0032286","count":4},{"id":"GO:0006675","count":4},{"id":"GO:0006809","count":4},{"id":"GO:0000001","count":4}]},{"hash":"704922349093150728","title":"Unknown","description":"The top terms show a scattered mix of processes (corneocyte development, renal water transport, redox homeostasis, PI dephosphorylation, mRNA stability, DNA recombination, hemolysis, aging/ transcription coactivator activity) and several entries are obsolete, indicating no clear, cohesive biological function tying the cluster together. Hence no confident, specific functional label can be assigned.","confidence":"","size":15,"edges":5,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0003335","count":5},{"id":"GO:2001153","count":5},{"id":"GO:0045454","count":5},{"id":"GO:0046856","count":5},{"id":"GO:2000327","count":5}]},{"hash":"1197255845300935036","title":"Synaptic vesicle trafficking and neurotransmitter release","description":"The GO terms are dominated by neuronal synaptic functions: synaptic vesicle exocytosis, neurotransmitter transport/secretion, and regulation of synaptic plasticity, pointing to vesicle cycling and neurotransmitter release in neurons. Additional transport terms for amino acids, metabolites, and ions likely reflect metabolic support roles in neuronal activity.","confidence":"High","size":15,"edges":23,"triangles":10,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0031915","count":4},{"id":"GO:0030073","count":4},{"id":"GO:0006836","count":4},{"id":"GO:0016079","count":4},{"id":"GO:0046928","count":4}]},{"hash":"1602434809355867555","title":"Developmental patterning and organogenesis","description":"The top GO terms point to development of multiple organs and body regions (heart, pancreas, pituitary, nucleus accumbens) and pattern specification (anterior/posterior, bilateral symmetry), suggesting the proteins cluster around broad developmental processes rather than a single molecular function. Some metabolic terms are present but appear less central to the main theme. ","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0003007","count":15},{"id":"GO:0021983","count":15},{"id":"GO:0010133","count":15},{"id":"GO:1901023","count":15},{"id":"GO:0021768","count":15}]},{"hash":"865017729491890455","title":"Actin Cytoskeleton Remodeling via Small GTPases","description":"This cluster centers on actin dynamics and small GTPase signaling: filopodium assembly, actin filament polymerization, small GTPase-mediated signal transduction, and regulation of GTPase activity, plus adhesion-dependent cell spreading. Together these terms imply a cohesive theme of actin cytoskeleton remodeling driven by Ras/Rho-family GTPases, underpinning protrusive structures and cell spreading; occasional heart development terms may reflect broader developmental roles of cytoskeletal regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046847","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0007264","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0043552","count":5}]},{"hash":"2069945430139379211","title":"Synaptic vesicle trafficking and receptor recycling","description":"GO terms cluster around neuronal vesicle trafficking and exocytosis: SNARE assembly, ER-Golgi transport, Golgi organization, and insertion/recycling of postsynaptic receptors, along with long-term potentiation and norepinephrine secretion, indicating a focus on synaptic vesicle cycling and receptor trafficking in neurons.","confidence":"High","size":15,"edges":74,"triangles":185,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":10},{"id":"GO:0090161","count":7},{"id":"GO:0035493","count":7},{"id":"GO:0098967","count":7},{"id":"GO:0048280","count":6}]},{"hash":"782667013024508145","title":"Placental development and ubiquitin regulation","description":"The top GO terms cluster around placental and embryonic development (trophoblast giant cell differentiation, endocardial EMT, placental/embryonic development, left-right patterning, cartilage morphogenesis, endocrine system development) and ubiquitin-mediated processes (ubiquitin-dependent protein catabolic process, protein ubiquitination), suggesting a developmental program regulated by ubiquitin pathways, with placental differentiation as a key facet.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0060707","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0035270","count":5}]},{"hash":"1969233293641996639","title":"Neuronal adhesion and axon guidance","description":"The cluster is enriched for neural connectivity and guidance terms, notably dopaminergic neuron axon guidance and synapse assembly, with strong signals for cell\u2013cell adhesion (homophilic/heterophilic). Planar polarity\u2013related guidance and migration terms further support a theme of coordinated neural development and pathfinding driven by adhesion and polarity cues.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036514","count":5},{"id":"GO:0007157","count":5},{"id":"GO:1904938","count":5},{"id":"GO:0090251","count":5},{"id":"GO:0048105","count":5}]},{"hash":"2177545470118592250","title":"Glycan biosynthesis and cell-surface glycoprotein function","description":"Top GO terms point to glycosylation and glycoprotein modification (poly-N-acetyllactosamine biosynthesis, Lewis A epitope biosynthesis, arabinogalactan protein metabolism, O-linked glycosylation via hydroxyproline) together with cell-surface and adhesion-related processes (follicle cell adhesion, root hair development, development of insect visual primordia, formation of infection structures). This suggests a common theme: glycan production and glycoprotein-mediated cell-surface interactions that influence development and tissue organization across species.","confidence":"High","size":15,"edges":14,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030311","count":5},{"id":"GO:0001744","count":5},{"id":"GO:0042248","count":5},{"id":"GO:0075015","count":5},{"id":"GO:0048354","count":5}]},{"hash":"835275663222658772","title":"Mitochondrial amino acid and metabolite transport","description":"The cluster shows strong representation of transport processes related to mitochondria (iron import into mitochondrion, alpha-ketoglutarate, malate-aspartate shuttle, glycine and ornithine transport, mitochondrial ATP transmembrane transport) and a cellular response to amino acid starvation, suggesting a cohesive theme around mitochondrial handling of amino acids and other metabolites. Some terms (e.g., female pregnancy) seem incidental, but do not override the dominant transport/metabolic pattern. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0034198","count":14},{"id":"GO:0048250","count":11},{"id":"GO:0036233","count":11},{"id":"GO:0000066","count":11},{"id":"GO:0015742","count":11}]},{"hash":"2181565920169097836","title":"Proteostasis and mitophagy","description":"The cluster is dominated by ubiquitin-dependent protein catabolic processes, autoubiquitination, and aggresome assembly, along with mitophagy and regulation of mitochondrial dynamics. While there are insulin secretion terms, the strongest common theme is cellular protein quality control coupled with mitochondrial maintenance, i.e., proteostasis and mitophagy. Confidence: High","confidence":"","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0033132","count":5},{"id":"GO:0000423","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0055069","count":5}]},{"hash":"110667049552924643","title":"Immune modulation and complement/coagulation regulation","description":"The cluster centers on immune signaling and modulation (interleukin-10 production, T cell homeostasis), with strong signals for complement pathway regulation (classical and alternative) and coagulation/platelet-related processes (platelet activation, fibrinolysis, MAC activation). Together these terms point to a cohesive theme of immune regulation intertwined with complement and coagulation, i.e., immunomodulatory proteins that influence inflammation, defense, and thrombotic responses. The presence of apoptosis-related terms further supports regulation of immune cell fate. Unknown outliers like fertilization appear less connected to the dominant pattern.","confidence":"High","size":15,"edges":61,"triangles":136,"max_degree":12,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0032613","count":11},{"id":"GO:0010572","count":11},{"id":"GO:0046013","count":10},{"id":"GO:0051918","count":10},{"id":"GO:2001241","count":10}]},{"hash":"1058722883515657723","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":7,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0000472","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0048813","count":3}]},{"hash":"2003642309384962296","title":"Innate immune signaling and cellular regulation","description":"The top GO terms show defense response to virus and innate immune response prominently, suggesting immune-related functions. However, there are additional regulatory terms (negative regulation of DNA binding, translation, protein deubiquitination, and signaling-related processes like Wnt signaling and dendritic spine morphogenesis), indicating the cluster may center on broader cellular signaling regulation alongside immune modulation rather than a single pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043392","count":3},{"id":"GO:0042981","count":3},{"id":"GO:0016579","count":3},{"id":"GO:0051607","count":2},{"id":"GO:0045842","count":2}]},{"hash":"666800920316417317","title":"Mitotic and Neural Development","description":"These proteins cluster around cell division (mitotic cycle, cell division) and neural/gametogenic development (neuron projection development, nervous system development, spermatid development), with supporting terms like microtubule-based movement. Ribosome biogenesis and protein localization to cell junction suggest active growth and organization during development. Taken together, the cluster appears focused on mitosis and neural/gamete developmental processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0007286","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1741089993504116630","title":"Mitochondrial Metabolite Transport","description":"The GO terms point to transport of various metabolites into and out of mitochondria (iron, glycine, ornithine, alpha-ketoglutarate, malate-aspartate shuttle, ATP), reflecting mitochondrial metabolite exchange and energy metabolism. Additional terms about fatty acid response and insulin signaling align with metabolic regulation, but the core theme is mitochondrial transport/metabolism.","confidence":"High","size":15,"edges":19,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048250","count":8},{"id":"GO:0036233","count":8},{"id":"GO:0000066","count":8},{"id":"GO:0015742","count":8},{"id":"GO:0043490","count":8}]},{"hash":"1970475791779739607","title":"Hypoxia-Responsive Signaling and Cytoskeletal Remodeling","description":"The top terms point to a hypoxia response together with broad kinase signaling (GTPase and serine/threonine phosphorylation) and actin cytoskeleton regulation via Arp2/3. The inclusion of cell-cycle and DNA damage checkpoint terms suggests stress-activated signaling that coordinates cytoskeletal dynamics with cell-cycle control, forming a cohesive theme rather than separate processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0031954","count":8},{"id":"GO:0051028","count":8},{"id":"GO:2000601","count":8}]},{"hash":"1637100135616604210","title":"Transcription Regulation and Telomere Maintenance","description":"The top GO terms cluster around transcription control (negative regulation of NF-kappaB, negative regulation of transcription by RNA polymerase II, DNA-templated transcription) and telomere biology (positive regulation of telomere maintenance via telomerase, protein localization to chromosome telomeric region). While a few terms are unrelated (e.g., heart conduction, symbiont entry, epithelial polarity), the dominant signal is transcriptional regulation together with telomere-related processes, suggesting a set of proteins involved in gene expression regulation and chromosome end maintenance rather than a single, cohesive pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0016049","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0046718","count":2}]},{"hash":"1478338264513152115","title":"Antiviral immunity and ubiquitination","description":"The cluster centers on host antiviral defense, with terms for defense against virus, innate immune response, suppression of viral release, autophagy, and various ubiquitination processes (including protein autoubiquitination and K6-linked ubiquitination), as well as NF-kappaB regulation. While V(D)J recombination appears, the dominant signal is antiviral immunity and ubiquitin-mediated regulation, supported by autophagy-related processes. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":3},{"id":"GO:1901253","count":2},{"id":"GO:0033151","count":2},{"id":"GO:0051865","count":2},{"id":"GO:1902187","count":2}]},{"hash":"2210382286087547937","title":"Diverse Signaling and Immune/Developmental Differentiation","description":"The top GO terms span a mix of signaling pathways (Wnt, integrin), barrier function (endothelial intestinal barrier), metabolic/developmental processes (adipose tissue development), organelle targeting (peroxisome matrix docking), and immune differentiation (B cell and NK T cell differentiation), as well as inflammatory and regulatory signals. This breadth suggests a cluster governed by general signaling and differentiation roles across immune, vascular, and development contexts rather than a single cohesive function. Therefore the label reflects the diversity of signaling and development/immune differentiation represented.","confidence":"Medium","size":15,"edges":16,"triangles":0,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060378","count":11},{"id":"GO:0090557","count":11},{"id":"GO:0090263","count":11},{"id":"GO:0007229","count":11},{"id":"GO:0016560","count":11}]},{"hash":"544174212403223823","title":"Neurodevelopment and Synaptic Assembly","description":"This cluster is dominated by neural development signals, especially neuron projection development and positive regulation of synapse assembly, pointing to proteins involved in neural differentiation and synaptic connectivity. Other terms reflect broader developmental processes (multicellular organism development, lens fiber differentiation) and general cellular remodeling (chromatin organization, apoptosis), but the neural development/synapse theme is the strongest. ","confidence":"High","size":15,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0031175","count":3}]},{"hash":"277133027283779542","title":"Amino Acid Transport and Macrophage Activation","description":"This cluster centers on transmembrane import of several amino acids (arginine, ornithine, lysine, serine, methionine, etc.), suggesting an amino acid transporter theme. The presence of macrophage activation and nitric oxide production terms hints at a link between amino acid uptake, particularly arginine, and inflammatory macrophage function, making the transport and inflammatory response a coherent, if combined, theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:0097640","count":2},{"id":"GO:0042941","count":2},{"id":"GO:0097638","count":2},{"id":"GO:0006527","count":2}]},{"hash":"570450342456848382","title":"Osteogenesis and extracellular matrix organization","description":"The predominant GO terms point to bone formation: osteoblast differentiation, ossification, bone mineralization, and extracellular matrix organization, with supporting roles for cell adhesion and growth factor signaling. A few terms relate to RNA splicing or chromatin modification, but they are secondary to the bone/ECM theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":1},{"id":"GO:0071363","count":1},{"id":"GO:0030282","count":1},{"id":"GO:0001649","count":1},{"id":"GO:0001503","count":1}]},{"hash":"572547791555402356","title":"Dopaminergic GPCR signaling and behavioral responses","description":"The top GO terms center on dopaminergic synaptic transmission, eating behavior, and sensitization, all pointing to dopamine-mediated neural signaling and related behavioral regulation. The GPCR signaling via cGMP and the other shared terms suggest a broader theme of GPCR-driven signaling with neuroendocrine and behavioral outputs, even though a few terms pertain to peripheral processes. Overall, the cluster appears to reflect dopamine-related neural signaling and associated behavioral responses.","confidence":"Medium","size":15,"edges":68,"triangles":163,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":15},{"id":"GO:0042755","count":15},{"id":"GO:0001963","count":15},{"id":"GO:0007199","count":15},{"id":"GO:1900134","count":15}]},{"hash":"1533650119496044746","title":"Axon guidance and synaptic plasticity","description":"This cluster\u2019s terms revolve around neural development and connectivity: axon target recognition, axonal fasciculation, corpus callosum development, and long-term synaptic depression indicate guidance of axons and maturation of neural circuits, with social behavior pointing to functional outcomes of these circuits. While some transcription-related terms appear, the dominant theme is guidance and regulation of synaptic connections in the brain.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007412","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0043085","count":2},{"id":"GO:0016578","count":2}]},{"hash":"2174551506465779034","title":"Glycinergic Neurotransmission and Brain Development","description":"This cluster centers on glycinergic synaptic transmission and amino acid transport, with clear links to glycine import/transport and regulation of neurotransmitter release. Supporting terms also touch on dopamine/serotonin-related signaling and brain development regions (thalamus, adenohypophysis), suggesting a broader neural signaling and development theme rather than a single metabolic pathway. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021984","count":7},{"id":"GO:0036233","count":7},{"id":"GO:1905847","count":7},{"id":"GO:0014064","count":7},{"id":"GO:0060092","count":7}]},{"hash":"647527515161032380","title":"RNA splicing and translation initiation","description":"Most of the top GO terms point to RNA processing in the spliceosome (splicing, snRNP assembly, polyadenylation) and related post-transcriptional steps, with a couple of translation initiation/reinitiation terms. A few terms (seed germination, aging) appear as outliers or annotation noise, but the dominant pattern is RNA maturation and initial translation steps, justifying a label focused on RNA splicing and translation initiation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3}]},{"hash":"765920684640980506","title":"Embryonic Morphogenesis and Tissue Development","description":"The highlighted GO terms cluster around embryonic development and tissue morphogenesis across multiple lineages (palate roof formation, mesoderm and cartilage morphogenesis, hair follicle morphogenesis, placenta/endocrine development, EMT), suggesting a cohesive theme of developmental patterning and differentiation.","confidence":"High","size":15,"edges":22,"triangles":6,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":11},{"id":"GO:0060707","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0031069","count":8},{"id":"GO:0010957","count":8}]},{"hash":"922372077757483046","title":"Neural and sensory organ development","description":"The top GO terms are dominated by nervous system development (forebrain, cerebellum, trigeminal ganglion) and sensory organ morphogenesis (embryonic eye morphogenesis, camera-type eye development), with additional broad developmental processes like multicellular organism development and somitogenesis. A stray fertilization term is present but does not define the core signal. Overall, the cluster appears to reflect a developmental program centered on neural and sensory tissues, with some muscle development involvement. ","confidence":"High","size":15,"edges":7,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0002087","count":7},{"id":"GO:0030900","count":7},{"id":"GO:0021549","count":7},{"id":"GO:0061551","count":7},{"id":"GO:0048048","count":7}]},{"hash":"2231064569912262479","title":"Cardiac Conduction and Action Potentials","description":"The top GO terms point to cardiac electrical activity\u2014SA node and atrial/ventricular action potentials, and heart-rate regulation by cardiac conduction\u2014suggesting a coherent theme around cardiac electrophysiology. Additional terms for cell-cell adhesion and immune responses may reflect tissue interactions or shared signaling contexts, but the dominant signal is cardiac conduction and excitability.","confidence":"Medium","size":15,"edges":82,"triangles":230,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0086015","count":6},{"id":"GO:0060307","count":6},{"id":"GO:0060371","count":6}]},{"hash":"1437430955298105684","title":"Cardiac development and signaling pathways","description":"This cluster is enriched for terms related to heart formation and function, including regulation of SA node cell action potential, right atrium morphogenesis, and venous endothelial differentiation, along with signaling pathway regulation (ephrin receptor, Notch, GPCR, and serine/threonine kinase activity). The overall theme points to cardiovascular development and signaling, with a minor neural signaling item, which does not override the primary cardiac focus.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901187","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0003213","count":2},{"id":"GO:0060843","count":2}]},{"hash":"2076698065859510724","title":"Telomere maintenance and chromosome-end regulation","description":"The top GO terms center on telomere maintenance via telomerase, localization to telomeric regions, and regulation of telomere length, along with mitotic processes like spindle assembly and cohesion at chromosome ends. This pattern suggests a functional focus on chromosome-end maintenance and chromosome segregation during cell division, even though some signaling terms appear less central. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:0098907","count":5},{"id":"GO:0032212","count":5},{"id":"GO:0070198","count":5},{"id":"GO:0016055","count":5}]},{"hash":"1893937690067965859","title":"Dopaminergic GPCR Signaling in Cardiovascular Regulation","description":"The terms cluster around dopamine-related GPCR pathways (adenylate cyclase and cGMP signaling) that influence neural dopamine transmission, platelet activation, blood pressure, and renin secretion, with behavioral aspects such as eating and sensitization. This supports a cohesive theme of dopamine-mediated GPCR signaling coordinating cardiovascular and neural regulation, with a possible background role for cellular energy metabolism reflected by the electron transport chain term.","confidence":"High","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030168","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0007190","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0045777","count":13}]},{"hash":"2008245473095603304","title":"Dopaminergic GPCR Signaling and Metabolic Regulation","description":"The cluster\u2019s top GO terms are dominated by GPCR signaling, especially dopamine-related synaptic transmission and adenylate cyclase/cGMP pathways, which aligns with dopaminergic signaling in neurons. Associated terms like feeding behavior and blood pressure regulation suggest a link to metabolic and cardiovascular regulation. Additional energy-related terms (electron transport chain, heat generation) support a broader metabolic context around neuronal signaling. Overall, the cluster seems centered on dopaminergic GPCR signaling with links to metabolic and cardiovascular outputs.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0035025","count":13},{"id":"GO:0046960","count":11}]},{"hash":"1248947141506829116","title":"Dopaminergic GPCR signaling and metabolic regulation","description":"This cluster centers on dopaminergic synaptic transmission and GPCR signaling with cGMP, suggesting neural dopaminergic signaling as a core theme. It also includes terms related to neuroendocrine control (blood pressure, renin secretion) and behavior (eating behavior, sensitization), with energy metabolism signals (electron transport chain, heat generation) that together imply a coordinated neural signaling network linking reward, metabolism, and physiological regulation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0035025","count":13},{"id":"GO:0046960","count":11}]},{"hash":"536502900070997742","title":"Glycan biosynthesis","description":"The cluster\u2019s top terms are heavily skewed toward carbohydrate biosynthesis and glycosylation, including poly-N-acetyllactosamine biosynthetic process, Lewis a epitope biosynthesis, and O-linked glycosylation via hydroxyproline, plus related mucilage biosynthesis. While a few terms are clearly developmental (e.g., root hair development, insect visual primordium formation, follicle epithelium polarity/adhesion), there isn\u2019t a single cohesive function beyond glycan assembly/modification that ties all entries together. Given the mixture but clear glycosylation signal, the label \u201cGlycan biosynthesis\u201d best captures the shared theme with moderate confidence.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0030311","count":1},{"id":"GO:0001744","count":1},{"id":"GO:0042248","count":1},{"id":"GO:0075015","count":1}]},{"hash":"1394780410403980798","title":"Cell Adhesion and Cytoskeletal Signaling","description":"The cluster features multiple GO terms tied to cell adhesion and integrin signaling, as well as actin filament polymerization, pointing to roles in cell\u2013cell/matrix interactions and cytoskeletal dynamics. Additional terms related to axon guidance and neuron differentiation suggest neural contexts, while barrier establishment and lysosome localization imply membrane trafficking and junction integrity. Together, these terms converge on a theme of adhesion and cytoskeletal remodeling governing movement, junctions, and signaling in neural and epithelial contexts.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007229","count":4},{"id":"GO:0043652","count":4},{"id":"GO:0007155","count":4},{"id":"GO:0090528","count":3},{"id":"GO:0061462","count":3}]},{"hash":"904623594054223369","title":"Unknown","description":"The top GO terms span diverse and unrelated processes\u2014from mast cell degranulation and endothelial activation to brain development, EMT in heart structures, cartilage formation, and even nematode tail morphogenesis\u2014plus DNA replication and synapse maturation. With no clear shared function linking these terms and an empty edge/topology, this cluster does not reflect a cohesive biological theme, so the label is Unknown with no confidence.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043303","count":2},{"id":"GO:0060030","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0003360","count":2},{"id":"GO:0060039","count":2}]},{"hash":"1015990806139563638","title":"Immune Regulation and Cell-Cell Adhesion","description":"The cluster's GO terms cluster around immune modulation (negative regulation of cytotoxic T cell degranulation; negative regulation of macrophage activation; positive regulation of dendritic cell differentiation; positive regulation of monocyte chemotactic protein-1 production) and cell-cell adhesion (heterophilic adhesion; paranodal junction assembly; AV node adhesion). Together these suggest proteins involved in immune signaling at cell interfaces across tissues. A few terms like receptor-mediated virion attachment and mechanosensation detection are less central but may reflect shared surface receptors or structural proteins. Overall, the label captures the dominant theme of immune regulation linked to cell adhesion.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":6},{"id":"GO:0050910","count":5},{"id":"GO:0046813","count":4},{"id":"GO:2001200","count":4},{"id":"GO:0007157","count":4}]},{"hash":"280720592531808799","title":"Unknown","description":"The top GO terms span a highly diverse set of processes (telomere maintenance/localization, cardiac signaling, NF-kappaB signaling, epithelial polarity, actin assembly, fat differentiation, NOD2 signaling, and neuronal development) with no clear shared function, so there\u2019s no cohesive theme to label; thus the cluster is Unknown and unconfident. ","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:0070198","count":3},{"id":"GO:0086070","count":3},{"id":"GO:0007253","count":3},{"id":"GO:1900827","count":3}]},{"hash":"1727284280011870812","title":"RNA Pol II transcription regulators","description":"Most proteins cluster around GO terms for transcription control by RNA polymerase II (negative regulation of transcription by RNA Pol II and DNA-templated transcription). While a couple of outlier terms hint at broader roles (T cell receptor signaling, brain development), the dominant signal is transcriptional regulation, suggesting these proteins function mainly as RNA Pol II transcription regulators.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007568","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0007420","count":2}]},{"hash":"940857587787107572","title":"Neuronal Motility and Survival Regulation","description":"The top GO terms cluster around nervous system function and movement, including visual perception, regulation of motor neuron apoptosis, locomotor rhythm, and axonemal dynein\u2013related motility. Additional terms touch on transcriptional regulation and apoptosis, suggesting broader signaling linked to neuron function and cell movement. Overall, the cluster likely reflects neuronal/motor activity and survival pathways rather than a single pathway, hence this label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:2000672","count":2},{"id":"GO:0070286","count":2},{"id":"GO:0003146","count":2},{"id":"GO:1904059","count":2}]},{"hash":"1116988108377781925","title":"Brain and neural development","description":"This cluster is enriched for nervous system and brain development terms: forebrain and brain development, spinal cord development, and neuron projection development. The inclusion of microtubule-based movement aligns with neuronal transport during neurite outgrowth. Although other development terms appear (e.g., lens fiber, skeletal system), the dominant signal is neural development.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0007018","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0007275","count":3}]},{"hash":"2292946757823644528","title":"Glutathione-Driven Redox Homeostasis and Detoxification","description":"Redox balance and detoxification emerge as the dominant theme: multiple terms point to cellular redox homeostasis, oxidant detoxification, glutathione metabolism, and protein glutathionylation. The presence of nucleotide-excision repair and arsenic response terms supports a broader oxidative stress response and DNA damage repair context. A few terms (like osteoblast differentiation and cell cycle regulation) may reflect secondary or pleiotropic connections but do not override the redox-focused signal. Overall, the cluster seems centered on maintaining redox balance through glutathione-dependent pathways and detoxification mechanisms.","confidence":"High","size":14,"edges":39,"triangles":85,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":8},{"id":"GO:0098869","count":8},{"id":"GO:0009072","count":7},{"id":"GO:0006289","count":7},{"id":"GO:0051726","count":7}]},{"hash":"1378966541502743855","title":"GPCR-Mediated Signaling and Second Messenger Pathways","description":"The cluster centers on GPCR-driven signaling: dopamine and adrenergic receptor pathways, activation of adenylate cyclase and PLC, and regulation of GTPase activity, all hallmark steps of G-protein coupled signaling that funnel into cAMP and calcium second messengers. The presence of phototransduction and heart development terms further supports GPCR involvement across sensory and cardiovascular contexts.","confidence":"High","size":14,"edges":37,"triangles":36,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":12},{"id":"GO:0060158","count":12},{"id":"GO:0007603","count":12},{"id":"GO:0043950","count":12},{"id":"GO:0071880","count":12}]},{"hash":"1961454407789780656","title":"Mitochondrial gene expression and RNA processing","description":"The top GO terms point to mitochondrial-related processes such as DNA-templated transcription, mitochondrial translation, and assembly of the mitochondrial ATP synthase complex, suggesting a role in mitochondrial gene expression and energy metabolism. The presence of RNA processing terms (splicing and various mRNA decay pathways) indicates involvement in RNA metabolism as well. Together, these hints support a cluster centered on coordinating gene expression with mitochondrial function and RNA processing.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0033615","count":2},{"id":"GO:0008203","count":2},{"id":"GO:0070131","count":2}]},{"hash":"1345298138146050227","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by ribosome-related processes: ribosome biogenesis, cytoplasmic translation, tRNA modification, and export of the ribosomal large subunit, plus protein homooligomerization\u2014all pointing to a core ribosome/translation module that supports cell growth and division (cell cycle).","confidence":"High","size":14,"edges":20,"triangles":0,"max_degree":11,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0051260","count":7},{"id":"GO:0006400","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0007049","count":6}]},{"hash":"1914989480157122821","title":"Embryonic and adipocyte development with innate signaling","description":"The cluster shows strong emphasis on developmental processes across tissues (heart, skeletal system, embryonic development, and fat cell differentiation), with additional signals for immune-related pathways (TLR9 signaling and LPS response) and autophagy; overall, a developmental program with concurrent innate signaling.","confidence":"Medium","size":14,"edges":14,"triangles":4,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0045444","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0001701","count":2},{"id":"GO:0045598","count":2}]},{"hash":"828772548202961407","title":"Cartilage formation and ECM signaling","description":"This cluster is enriched for cartilage condensation, collagen-activated receptor signaling, PDGF receptor signaling, cell adhesion, and Wnt/TGF-beta pathways\u2014together pointing to cartilage development and extracellular matrix\u2013mediated signaling in connective tissue and skeletal remodeling. Some terms (cellular response to molecule of fungal origin) may be less specific, but the dominant themes are ECM interactions and growth-factor signaling in cartilage/connective tissue.","confidence":"Medium","size":14,"edges":11,"triangles":2,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0048008","count":8},{"id":"GO:0001502","count":8},{"id":"GO:0046676","count":7},{"id":"GO:0038063","count":7}]},{"hash":"1772160946112154207","title":"Multi-Substrate Membrane Transporters","description":"This cluster is dominated by diverse transmembrane transporter functions, with GO terms for nitrate, xylose, trehalose, sodium ions, and organic cation transport, indicating a group of proteins that mediate the movement of multiple solutes across membranes. A few terms related to signaling or learning appear but are peripheral to the core transport theme, supporting a label centered on membrane transporters with multiple substrates.","confidence":"High","size":14,"edges":11,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":4},{"id":"GO:0070374","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0015753","count":3},{"id":"GO:0070715","count":3}]},{"hash":"238417672486411649","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":75,"triangles":220,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0010610","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0071035","count":2}]},{"hash":"1698004683709590613","title":"Broad metabolic pathways with quinone biosynthesis","description":"The cluster shows multiple metabolic catabolic processes (adenine, mandelate, amino acids) and gluconeogenesis, along with biosynthesis of quinones (menaquinone and phylloquinone). There are a few outlier terms (lung development, regulation of apoptosis, cell wall organization) that don\u2019t fit a single cohesive pathway, but the dominant signal is metabolic activity and cofactor biosynthesis. This suggests a general metabolism-focused module rather than a specific functional complex.","confidence":"Medium","size":14,"edges":25,"triangles":17,"max_degree":11,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006146","count":5},{"id":"GO:0030324","count":3},{"id":"GO:0009405","count":3},{"id":"GO:0019596","count":3},{"id":"GO:0009063","count":3}]},{"hash":"1082707836576901876","title":"Mitosis and Vesicle Trafficking","description":"The cluster shows strong signals for core mitotic processes: DNA replication, mitotic cell cycle, cell division, and CENP-A chromatin assembly, plus microtubule severing and cell morphogenesis, pointing to chromosome dynamics during division. The concurrent enrichment for vesicle-related terms (ER to Golgi transport, intralumenal vesicle formation, ubiquitin-dependent ERAD pathway) suggests a link to intracellular trafficking that can intersect with mitosis (e.g., organelle reorganization and protein turnover during division). Together, these terms imply a cohesive theme around mitosis with supporting trafficking roles. Confidence: Medium","confidence":"Medium","size":14,"edges":68,"triangles":179,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0046330","count":5},{"id":"GO:0070676","count":4},{"id":"GO:0000902","count":4}]},{"hash":"68582859595619502","title":"TGF-beta signaling-driven embryonic development and EMT","description":"This cluster combines transcriptional regulation with TGF-beta/SMAD signaling and EMT, including gastrulation and dorsal convergence, plus development of tissues such as brainstem, pericardium, cartilage, and osteoblasts, indicating a vertebrate embryogenesis-focused module.","confidence":"High","size":14,"edges":71,"triangles":196,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0001702","count":6},{"id":"GO:0007183","count":6},{"id":"GO:0007179","count":6},{"id":"GO:0060030","count":4}]},{"hash":"1777697921446323973","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning transcriptional regulation, immune differentiation and response, vascular barrier processes, neural junction localization, and developmental axes. Although there are recurring themes around endothelial function (endothelial barrier establishment, fibrinolysis, coagulation, blood pressure regulation) and innate immune signaling (LPS response, marginal zone B cell differentiation), the inclusion of neural junctions and axis specification prevents identifying a single coherent functional theme for the cluster. As a result, I cannot assign a concise, representative label beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0002315","count":5},{"id":"GO:0032496","count":4},{"id":"GO:1903142","count":4},{"id":"GO:0030913","count":4}]},{"hash":"254048370348729531","title":"Lymphocyte Activation and Immune Signaling","description":"The strongest terms center on immune signaling and lymphocyte function: IL-4\u2013mediated signaling, NK cell\u2013mediated cytotoxicity, and positive regulation of T cell proliferation, suggesting a cluster oriented toward immune cell activation and effector responses. Additional terms such as ubiquitination and ER stress\u2013related apoptotic signaling fit within the broader realm of cellular signaling and regulation in immune contexts. Other metabolic terms exist, but they are less central to the core theme, so the label focuses on immune activation and signaling.","confidence":"Medium","size":14,"edges":89,"triangles":340,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902237","count":14},{"id":"GO:0006641","count":14},{"id":"GO:0035771","count":14},{"id":"GO:0046641","count":14},{"id":"GO:2000251","count":14}]},{"hash":"186071583459433835","title":"Proteoglycan and glycosaminoglycan biosynthesis","description":"The top GO terms cluster around proteoglycan and glycosaminoglycan pathways (keratan sulfate and heparin proteoglycan biosynthesis, N-acetylglucosamine metabolism, and related glycosaminoglycan processes), pointing to extracellular matrix assembly and ECM-related development. Occasional terms like lung development and angiotensin regulation fit the broader context of tissue remodeling and vascular ECM environments, though a few items (phosphorylation, antibiotic response) seem noise. Overall, a coherent ECM/glycosaminoglycan biosynthesis theme emerges.","confidence":"Medium","size":14,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0002002","count":2}]},{"hash":"1085614309541000809","title":"Immune signaling and endocytosis","description":"The cluster shows frequent involvement in innate immune response, B cell receptor signaling, and thymus development, pointing to immune system signaling as the core theme. Endocytosis appears alongside these immune processes, suggesting coordinated antigen uptake and signaling. Other terms (integrin signaling, ER stress\u2013induced apoptosis, mitochondrial regulation) reflect supportive roles in immune cell function and cellular stress responses. While some terms relate to growth regulation, the immune-centric terms dominate, justifying an immune signaling label.","confidence":"Medium","size":14,"edges":29,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1902237","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0048538","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0014911","count":2}]},{"hash":"1011178908881825514","title":"Neural development and immune signaling","description":"The cluster is enriched for neuron- and synapse-related terms (cell adhesion, synapse assembly, nervous system development) alongside immune functions (innate/adaptive responses, complement activation, T cell regulation). A bone maturation term is present but seems less central, so the dominant theme is neural development with immune signaling.","confidence":"Medium","size":14,"edges":27,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0007156","count":8},{"id":"GO:0007399","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0006958","count":6}]},{"hash":"2007332236707115129","title":"Thermogenesis and pain-related GPCR signaling","description":"The cluster shows strong representation of GO terms related to diet-induced thermogenesis, temperature stimulus response, and sensory perception of pain, together with GPCR signaling and dopaminergic synaptic transmission. This points to a theme where temperature- and pain-related cues regulate energy balance and feeding through GPCR-dopamine pathways, with additional inflammatory/sensitization signals.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0045745","count":8},{"id":"GO:0006954","count":8}]},{"hash":"1829431444466679285","title":"Vertebrate placental development and embryonic morphogenesis","description":"The top GO terms cluster around placental development and maternal processes (placental development, parturition), with supporting terms for neural crest cell migration and morphogenesis, plus some unrelated but common developmental processes like mitochondrial outer membrane permeabilization and DNA integration. Taken together, this points to a group of vertebrate proteins involved in embryonic development and tissue morphogenesis, particularly placenta formation, with apoptosis-related processes as a broader context.","confidence":"Medium","size":14,"edges":37,"triangles":21,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0097345","count":9},{"id":"GO:0060137","count":9},{"id":"GO:0001893","count":9},{"id":"GO:1903547","count":9},{"id":"GO:0015074","count":6}]},{"hash":"318581784410635567","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":88,"triangles":329,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":10},{"id":"GO:0006458","count":10},{"id":"GO:0006469","count":10},{"id":"GO:0045454","count":10},{"id":"GO:1901621","count":10}]},{"hash":"1462561917112209808","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":30,"triangles":0,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0006458","count":3}]},{"hash":"1070300209625130278","title":"Innate immune cell recruitment and phagocytosis","description":"The cluster is dominated by GO terms related to innate immune response, phagocytosis regulation, and leukocyte recruitment (neutrophil extravasation, monocyte chemotaxis), along with cell adhesion, suggesting a core function in immune cell activation and trafficking. Some terms such as voltage-gated sodium channel clustering and muscle contraction appear less representative and may reflect broader cellular processes, but the prevalent theme is innate immunity and leukocyte movement. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0050766","count":3},{"id":"GO:0071639","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0051092","count":3}]},{"hash":"1935275355413241190","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071031","count":14},{"id":"GO:0000390","count":14},{"id":"GO:0000462","count":14},{"id":"GO:0006260","count":14},{"id":"GO:0001178","count":14}]},{"hash":"1731584225811482708","title":"Proteostasis and mitochondrial quality control","description":"This cluster shows a cohesive set of terms centered on protein homeostasis and stress responses, including ubiquitination, sumoylation, deglycosylation, and aggresome formation, along with mitophagy and regulation of mitochondrial fusion and ER-stress\u2013related apoptotic signaling. A minor outlier is erythrocyte differentiation, but the dominant themes point to proteostasis and mitochondrial quality control.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":1},{"id":"GO:0045648","count":1},{"id":"GO:0033132","count":1},{"id":"GO:0000423","count":1},{"id":"GO:0051865","count":1}]},{"hash":"72157786328113919","title":"Gustatory GPCR signaling and taste learning","description":"These proteins cluster around gustatory sensing and neurosensory GPCR signaling: sweet-taste detection, conditioned taste aversion, and GPCR pathways (PLC-activating and AC-inhibiting) with GABAergic modulation. While defense-related terms appear, most terms converge on taste perception and neural signaling, suggesting a gustatory signaling module.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":7},{"id":"GO:0000187","count":6},{"id":"GO:0007626","count":6},{"id":"GO:0001661","count":6},{"id":"GO:0007214","count":6}]},{"hash":"444571182745462872","title":"Filopodium formation and caveolin-mediated endocytosis","description":"The top GO terms point to actin-driven membrane protrusions (filopodium assembly, actin cortical patch assembly, plasma membrane tubulation) and membrane trafficking/endocytosis (caveolin-mediated endocytosis, caveola assembly, membrane invagination), plus a migration-related leading process. This suggests a cohesive theme of actin-based protrusions coupled with caveolae-mediated membrane remodeling during cell movement, especially in migrating neural contexts. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051044","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0045725","count":3},{"id":"GO:0072584","count":3},{"id":"GO:0010324","count":3}]},{"hash":"194286715899118838","title":"Autophagy-Linked Endosome-Lysosome Trafficking","description":"This cluster features GO terms tied to autophagosome maturation regulation (positive and negative), lysosome localization, and vesicle transport among the plasma membrane, endosomes, and Golgi, with Rab/Rap signaling components and microtubule-based movement. The convergence of autophagy regulation with endosomal-lysosomal trafficking suggests a module coordinating autophagy flux with endosome maturation and lysosome delivery.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043553","count":2},{"id":"GO:1903527","count":2},{"id":"GO:1901098","count":2},{"id":"GO:0032483","count":2},{"id":"GO:1901097","count":2}]},{"hash":"368302305633675000","title":"Nervous system development and axonal transport","description":"The cluster is dominated by GO terms related to neural development, axonogenesis, axonal transport (anterograde/retrograde), and microtubule/cytoskeletal organization (neurofilament assembly, polarity), with accompanying glial development (astrocyte, Schwann cells) and peripheral neuron processes. A couple of terms (cornification, skin barrier) may reflect broader structural processes or tissue cross-talk, but the overall theme centers on nervous system wiring and cytoskeletal dynamics.","confidence":"High","size":14,"edges":27,"triangles":17,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0019896","count":11},{"id":"GO:0070268","count":11},{"id":"GO:0030951","count":11},{"id":"GO:0055015","count":11},{"id":"GO:0014002","count":11}]},{"hash":"1835878701821122242","title":"Glycosylation in pollen germination and tube growth","description":"The terms show a clear focus on pollen development (pollen germination and pollen tube growth) combined with glycosylation and glycosphingolipid biosynthesis (N-glycan processing, N-linked glycosylation, protein sialylation, ganglioside biosynthesis). This suggests a theme of glycosylation- and lipid-modification processes underlying pollen maturation and tube growth, despite some non-plant terms that may reflect cross-annotation. ","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0009846","count":4},{"id":"GO:0006677","count":4},{"id":"GO:0006491","count":4},{"id":"GO:0071699","count":4},{"id":"GO:0021628","count":4}]},{"hash":"36139653719291777","title":"Lipoxygenase-driven inflammatory signaling","description":"The cluster shows multiple terms tied to lipid mediator production and inflammatory responses, notably leukotriene production, the lipoxygenase pathway, and cytokine/LPS responses, suggesting inflammation driven by lipid signaling. A few terms (cornification, Leydig cell differentiation) are less connected, so the overall theme remains inflammatory lipid signaling rather than a single highly specific process.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043085","count":3},{"id":"GO:0071364","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0070268","count":2},{"id":"GO:2001300","count":2}]},{"hash":"516515584736318023","title":"Ribosome biogenesis and translation","description":"This cluster centers on ribosome-related processes: large subunit assembly, translation, ribosome biogenesis, maturation of rRNA, and rRNA/tRNA methylation, suggesting a cohesive theme around ribosome assembly and function, including some mitochondrial translation aspects. ","confidence":"High","size":14,"edges":77,"triangles":231,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006355","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0070131","count":1}]},{"hash":"1859713405962459936","title":"Retroviral integration and proviral latency","description":"This cluster\u2019s top GO terms point to steps in the retroviral life cycle: entry into the host and nuclear penetration, reverse transcription (RNA-templated DNA biosynthesis), DNA integration, and establishment of integrated proviral latency, along with DNA recombination/replication. While some terms touch on host-symbiont interactions, the dominant signal is viral genome integration and latency. ","confidence":"High","size":14,"edges":42,"triangles":50,"max_degree":10,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0075732","count":5},{"id":"GO:0006278","count":5},{"id":"GO:1903704","count":5},{"id":"GO:0039651","count":5}]},{"hash":"1697338820621572821","title":"Unknown","description":"The top GO terms span multiple themes (neural development, transcription, immune/metabolic processes) with no single coherent function linking all terms. Because of this dispersion, a concise, specific label cannot be confidently assigned to represent the cluster's function; thus Unknown with no clear representative function is appropriate.","confidence":"","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0035284","count":6},{"id":"GO:0021571","count":6},{"id":"GO:0035470","count":6},{"id":"GO:0055089","count":5}]},{"hash":"1248748450569001513","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002031","count":5},{"id":"GO:0060707","count":4},{"id":"GO:0006294","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0006361","count":4}]},{"hash":"1359889750685599640","title":"Dopaminergic GPCR Signaling in Feeding and Reward","description":"Top GO terms point to a neural signaling module: dopaminergic synaptic transmission, eating behavior, sensitization, and GPCR pathways coupled to cGMP, suggesting roles in reward, feeding regulation, and sensory modulation. Some terms relate to vascular or immune responses, but the core theme remains neural dopaminergic signaling and GPCR-cGMP signaling.","confidence":"Medium","size":14,"edges":83,"triangles":284,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":14},{"id":"GO:0042755","count":14},{"id":"GO:0001963","count":14},{"id":"GO:0007199","count":14},{"id":"GO:1900134","count":14}]},{"hash":"587876689975711057","title":"Wnt-Driven Development and RNA Processing","description":"The top GO terms cluster around multicellular organism development and the Wnt signaling pathway, pointing to a developmental regulatory role. Additional terms for mRNA processing, splicing, and chromatin assembly suggest coordinated gene-expression control during development. The presence of broad, tissue- or species-spanning processes and the lack of protein interconnections (Edges 0) imply a general developmental program rather than a single, tight function. Confidence: Medium.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0043029","count":2}]},{"hash":"1713912244631370078","title":"Nervous system development and immune regulation","description":"This cluster centers on cell adhesion and signaling linked to nervous system development (peripheral nervous system development, myelination, AV node adhesion, heterophilic cell-cell adhesion, cell communication) and includes Hedgehog pathway activity (Smoothened signaling). It also contains GO terms for immune modulation (negative regulation of NK cell degranulation, macrophage activation; classical complement activation), suggesting an interconnected role for neural development and immune signaling. Overall, the proteins appear to function in tissue-level cell adhesion/signaling with neural development and immune-regulatory aspects.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":8},{"id":"GO:0006958","count":7},{"id":"GO:0045663","count":6},{"id":"GO:0043318","count":6},{"id":"GO:0043031","count":6}]},{"hash":"1938391079099293433","title":"Lens development in camera-type eye","description":"Top terms are dominated by visual perception and camera-type eye and lens fiber cell development (e.g., lens development in camera-type eye, lens fiber cell differentiation and morphogenesis), suggesting the cluster centers on lens/eye formation. Additional terms like morphogenesis of an epithelium and pituitary/midbrain development are present but less defining for the cluster.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":8},{"id":"GO:0043010","count":8},{"id":"GO:0070306","count":7},{"id":"GO:0002088","count":6},{"id":"GO:0000122","count":6}]},{"hash":"1064217334591800298","title":"Developmental Transcriptional Regulation","description":"These terms cluster around transcription by RNA polymerase II (including its regulation and miRNA transcription), along with multiple developmental processes such as neuron development, eye morphogenesis, and primitive streak formation. This pattern suggests a group of proteins that coordinate transcriptional programs during embryogenesis and tissue differentiation, rather than a single enzymatic pathway.","confidence":"High","size":14,"edges":61,"triangles":106,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0043011","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0007464","count":4},{"id":"GO:0007296","count":4}]},{"hash":"2182885797860963559","title":"Proteoglycan and GAG biosynthesis","description":"The cluster is dominated by GO terms for biosynthesis and metabolism of glycosaminoglycans and proteoglycans (including heparan, chondroitin, keratan, dermatan, and heparin proteoglycans) and related carbohydrate processes like N-acetylglucosamine metabolism. This points to a coherent theme of extracellular matrix proteoglycan assembly and sulfated GAG chain synthesis, with some ancillary hormone and xenobiotic metabolism associations.","confidence":"High","size":14,"edges":61,"triangles":138,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":11},{"id":"GO:0030206","count":11},{"id":"GO:0002002","count":10},{"id":"GO:0006711","count":10},{"id":"GO:0018146","count":10}]},{"hash":"1440232220032777729","title":"Innate Immune Activation and Antigen Presentation","description":"This cluster centers on innate immune signaling and dendritic cell function: terms for innate immune response, TLR2 signaling, dendritic cell antigen processing and presentation, IL-8 production, and macropinocytosis, plus actin remodeling related to uptake and movement. The convergence of these immune pathways suggests a cohesive theme of innate activation coupled with antigen presentation by dendritic cells.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051770","count":5},{"id":"GO:0051639","count":5},{"id":"GO:0034134","count":5},{"id":"GO:0002606","count":5},{"id":"GO:0051092","count":5}]},{"hash":"427243839781241594","title":"Immune Signaling and Cell-Cell Adhesion","description":"The top GO terms are dominated by immune-related processes: defense against bacteria, peptidoglycan detection, Fc-gamma receptor signaling for phagocytosis, immunoglobulin production, and positive regulation of T cell proliferation. These point to proteins involved in immune recognition, activation, and intercellular interactions, with a few outliers (sound sensation and cardiac action potential) that may reflect annotation noise. Overall, the cluster appears to center on immune signaling and cell adhesion mechanisms.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":4},{"id":"GO:0042102","count":4},{"id":"GO:0050910","count":4},{"id":"GO:0038096","count":3},{"id":"GO:0086014","count":3}]},{"hash":"77272176648697140","title":"Dopaminergic GPCR signaling and feeding behavior","description":"GO terms point to GPCR signaling and dopaminergic neurotransmission, particularly relating to feeding behavior and sensitization; the cGMP-linked GPCR pathway term supports this neural signaling theme. Other terms reflect broader GPCR-regulated physiological processes, but the core cluster centers on dopamine-related signaling and feeding behavior.","confidence":"High","size":14,"edges":6,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":14},{"id":"GO:0042755","count":14},{"id":"GO:0001963","count":14},{"id":"GO:0007199","count":14},{"id":"GO:1900134","count":14}]},{"hash":"1947959728251937515","title":"Dopaminergic GPCR-cAMP Signaling and Behavior","description":"The GO terms cluster around GPCR signaling that activates adenylate cyclase (cAMP) and include dopaminergic synaptic transmission, and behavior-related terms (eating, fear response, sensitization). This suggests a core theme of dopamine-centric GPCR signaling in the CNS affecting behavior, with peripheral terms (blood pressure regulation, renin secretion, electron transport) likely reflecting broader cellular processes or secondary associations. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":11},{"id":"GO:0007190","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0045777","count":11},{"id":"GO:0001662","count":10}]},{"hash":"1994335312921815377","title":"Signaling and Trafficking with Cytoskeleton","description":"The top GO terms cluster around signaling pathways (MAPK/JUN signaling, Wnt pathway regulation), cell cycle regulation, cytoskeleton dynamics (actin filament bundle assembly), and membrane trafficking (COPII vesicle loading, endocytosis). This suggests a coherent group of proteins involved in transducing signals to cytoskeletal remodeling and vesicle trafficking, with angiogenesis as a downstream/related process. A replication-related DNA repair term appears less connected and may reflect annotation noise. Overall, a cohesive signaling- to-trafficking with cytoskeleton theme. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":3},{"id":"GO:1990414","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0045737","count":2},{"id":"GO:0007258","count":2}]},{"hash":"1662647829699797521","title":"Female sex differentiation and steroid hormone metabolism","description":"The cluster centers on female reproductive development signals (female genitalia development, sex differentiation, maternal processes in parturition) and steroid-related metabolism (cholesterol catabolic and androgen metabolic processes) with vitamin D\u2013related responses, indicating a shared theme around sex-specific development and hormone-derived metabolism. Some terms are broader environmental responses, but the core pattern supports a reproductive/hormonal theme.","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0060137","count":2},{"id":"GO:0010164","count":2},{"id":"GO:0030540","count":2}]},{"hash":"1910615419287289135","title":"GTPase Signaling in Development","description":"The cluster is dominated by terms related to GTPase activity activation and regulation (GO:0090630; GO:0043547), with a clear emphasis on Rho signaling (GO:0035023) and downstream MAPK/ERK pathways (GO:0070374) and Wnt signaling (GO:0016055). This suggests a cohesive group of proteins involved in signaling networks that guide development and cell behavior, including heart development (GO:0007507). Some included terms (defense response to Gram-positive bacteria; transcription regulation) may be secondary associations rather than core themes. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0035023","count":2}]},{"hash":"2234435035119297611","title":"Dopaminergic GPCR Signaling and Feeding Behavior","description":"The top GO terms point to dopaminergic synaptic transmission and eating behavior, preceded by GPCR signaling with cGMP as a second messenger, which together suggest a core theme of dopamine-related neurotransmission and GPCR-cGMP signaling influencing feeding/sensitization. While there are additional terms referencing defense responses and heat generation that seem peripheral to the main theme, the strongest, most consistent signal is dopaminergic GPCR-mediated signaling linked to behavior and reward. The absence of network edges indicates it may be a loosely connected set centered on this signaling axis.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":5},{"id":"GO:0042755","count":5},{"id":"GO:0001963","count":5},{"id":"GO:0007199","count":5},{"id":"GO:1900134","count":5}]},{"hash":"2226945646122450380","title":"Ion Transport and Membrane Excitability","description":"This cluster is dominated by GO terms for sodium, potassium, and calcium ion transmembrane transport, membrane depolarization, and regulation of glutamatergic synaptic transmission, suggesting a coherent theme of ion transport governing cellular excitability and signaling. A few terms (peptidoglycan catabolic process, viral release from host cell) are less clearly connected and may reflect cross-annotation noise or broader functional associations.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":6},{"id":"GO:0035725","count":5},{"id":"GO:0009253","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0051966","count":5}]},{"hash":"1357904465432145354","title":"Embryonic Development and Morphogenesis","description":"Top GO terms indicate roles in placental/trophoblast differentiation, EMT in development, left-right patterning, and various morphogenetic processes (cartilage, hair follicle), pointing to a cohesive theme of embryonic development and tissue morphogenesis. A few terms related to ribosomal export and DNA replication initiation are present but do not redefine the cluster\u2019s main function.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0060806","count":14},{"id":"GO:0003323","count":14},{"id":"GO:0035270","count":14}]},{"hash":"1373811330093814985","title":"MVB-mediated protein sorting and degradation","description":"The top GO terms cluster around multivesicular body (MVB) assembly and sorting, and ubiquitin-dependent protein catabolic process via the MVB pathway, pointing to endosomal trafficking and targeted protein turnover as the core function. While some terms touch nuclear or cell-cycle processes, the strongest signal is endosomal sorting and degradation via MVB, which justifies this label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006303","count":1},{"id":"GO:0051103","count":1},{"id":"GO:0090116","count":1},{"id":"GO:0036258","count":1},{"id":"GO:0071985","count":1}]},{"hash":"105964100586577009","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms point to a broad set of developmental and morphogenetic processes across multiple tissues (placenta, heart, cartilage, hair, palate, pancreas) and patterning events, suggesting a general role in embryogenesis and organ formation rather than a single specific pathway.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":14},{"id":"GO:0003198","count":14},{"id":"GO:0060806","count":14},{"id":"GO:0003323","count":14},{"id":"GO:0035270","count":14}]},{"hash":"1167309931713533674","title":"Unknown","description":"The top GO terms span very different biological areas (signaling pathway regulation, magnesium transport, various metabolic processes, and retina development), with no clear unifying function linking the proteins. Some terms are obsolete or noisy, suggesting the cluster does not represent a coherent, single biological theme.","confidence":"","size":13,"edges":29,"triangles":40,"max_degree":10,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0030512","count":5},{"id":"GO:1903830","count":3},{"id":"GO:0019343","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0046296","count":3}]},{"hash":"994510729432697295","title":"Circadian Transcription Regulation","description":"The most represented GO terms cluster around transcriptional processes: DNA-templated transcription, transcription by RNA polymerase II, and especially circadian regulation of gene expression. This suggests the proteins in this cluster function primarily as regulators of gene expression with circadian control. Some terms touch on metabolism or stress responses (fatty acid homeostasis, ER unfolded protein response) which may reflect broader regulatory roles, but the dominant motif is transcriptional regulation, particularly circadian transcription.","confidence":"High","size":13,"edges":63,"triangles":167,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045872","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0032922","count":7},{"id":"GO:0043433","count":7}]},{"hash":"1644167621949183992","title":"Detoxification and inflammatory signaling regulation","description":"The GO terms cluster around detox and redox-related processes (glutathione derivative biosynthesis, xenobiotic catabolic process, response to L-ascorbic acid) and regulatory control of immune/inflammatory pathways (negative regulation of IL-1\u03b2 production, negative regulation of JNK activity), with additional hints of broader stress-response regulation (manganese response, muscle relaxation). This points to a cohesive theme of detoxification coupled with modulation of inflammatory signaling.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1901687","count":11},{"id":"GO:1905804","count":11},{"id":"GO:0042178","count":11},{"id":"GO:0006808","count":11},{"id":"GO:0032691","count":11}]},{"hash":"1871660551374637318","title":"Chromatin Regulation and Transcription Control","description":"This cluster centers on epigenetic regulation of gene expression, with themes of chromatin remodeling (nucleosome positioning, histone deacetylation), transcriptional control (DNA-templated transcription), nucleolar/rDNA localization, and genome stability (telomere maintenance), plus proteostasis aspects. The GO terms point to a cohesive axis of chromatin-mediated transcription regulation and genome maintenance, despite some older/obsolete annotations.","confidence":"Medium","size":13,"edges":71,"triangles":218,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":11},{"id":"GO:0045668","count":11},{"id":"GO:0060303","count":9},{"id":"GO:0006351","count":9},{"id":"GO:0016584","count":9}]},{"hash":"27123186329898124","title":"Nuclear transport and chromatin maintenance","description":"Proteins cluster around nucleus-related processes: nuclear import signals (NLS-bearing protein import into nucleus), ribosomal protein import, nuclear pore complex assembly, and mitotic nuclear membrane reassembly. In addition, meiotic sister chromatid cohesion at centromeres and transcription by RNA polymerase III point to chromatin organization and transcriptional control within the nucleus. Overall, the group appears focused on nuclear transport, chromatin maintenance, and related cell-cycle regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":7},{"id":"GO:0060188","count":4},{"id":"GO:2001241","count":4},{"id":"GO:0071230","count":4},{"id":"GO:0051292","count":4}]},{"hash":"1826471133826721555","title":"Bacterial central metabolism and quinone biosynthesis","description":"This cluster is enriched for core metabolic pathways (glycolysis, TCA cycle, fatty acid beta-oxidation) and amino-acid catabolism, along with biosynthesis of menaquinone and phylloquinone, indicating a cohesive metabolic module for energy production and electron carrier assembly in bacteria. The antibiotic biosynthetic term is present but appears secondary to the dominant energy and cofactor biosynthesis signals.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0010124","count":6},{"id":"GO:0009234","count":6},{"id":"GO:0042372","count":6},{"id":"GO:0006574","count":6}]},{"hash":"1568871217623929739","title":"Neuronal synaptic vesicle trafficking and development","description":"The cluster shows strong enrichment for neuron-specific processes, especially regulation of exocytosis and synaptic vesicle cycling (positive regulation of exocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle endocytosis), plus neural crest formation and dendrite morphogenesis, pointing to proteins involved in neuronal development and synaptic transmission. While some terms like angiogenesis and hypoxia are broader, they do not override the dominant neuronal signaling theme.","confidence":"High","size":13,"edges":21,"triangles":11,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0045921","count":5},{"id":"GO:0014029","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0006479","count":4}]},{"hash":"1954361902006637800","title":"Ubiquitin-Driven Immune and Stress Signaling","description":"The cluster's terms cluster around ubiquitin-dependent protein catabolic processes and K6-linked ubiquitination, along with innate immune response, defense against virus, and regulation of JNK cascade, suggesting a shared theme of ubiquitin-mediated regulation of stress and immune signaling. Some terms related to development and synaptic plasticity may reflect broader roles, but the core signal is ubiquitin-regulated stress/immune pathways.","confidence":"Medium","size":13,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0060292","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0003323","count":2}]},{"hash":"483621807801559002","title":"C-type lectin and Fc receptor innate signaling","description":"This cluster centers on innate immune recognition and activation, driven by GO terms such as stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, and cellular response to fungal origin, with accompanying NK cell chemotaxis regulation. While a few developmental terms appear, the dominant theme is immune signaling via C-type lectin and Fc receptors.","confidence":"High","size":13,"edges":70,"triangles":208,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":13},{"id":"GO:0060355","count":13},{"id":"GO:0036303","count":13},{"id":"GO:0072287","count":13},{"id":"GO:0071226","count":13}]},{"hash":"2274247824463022298","title":"Immune and developmental signaling processes","description":"The cluster shows a mix of GO terms centered on immune function (innate immune response, Th1-type immune response) alongside core signaling and development themes (GPCR signaling, Wnt signalosome assembly) plus tissue development terms (bone, uterus, kidney development). The addition of endosome-to-Golgi transport regulation and neural migration hints at roles in intracellular trafficking and neurodevelopment, suggesting these proteins participate in context-dependent signaling cross-talk between immune responses and development across tissues rather than a single tissue-specific function.","confidence":"Medium","size":13,"edges":18,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":10},{"id":"GO:0060348","count":10},{"id":"GO:0060065","count":8},{"id":"GO:1905279","count":8},{"id":"GO:0090394","count":8}]},{"hash":"1846035515988112209","title":"Bacterial LPS and carbohydrate biosynthesis","description":"These proteins show a strong signature for biosynthesis of surface polysaccharides (lipopolysaccharide and O antigen) and multiple carbohydrate metabolic pathways (glucose, sucrose, glycogen), with supplemental signals of antibiotic-related biosynthesis and transcription regulation. The clearest connected theme is bacterial cell envelope polysaccharide production and associated sugar metabolism, justifying a label centered on LPS and carbohydrate biosynthesis.","confidence":"Medium","size":13,"edges":9,"triangles":1,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0009103","count":4},{"id":"GO:0005978","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0017000","count":3}]},{"hash":"961372159874951531","title":"Neurodevelopment and Craniofacial Morphogenesis","description":"The cluster\u2019s top GO terms mostly point to developmental processes in neural and craniofacial tissues\u2014trigeminal ganglion development, cochlea morphogenesis, palate/roof of mouth development, organ induction, and general multicellular development. While innate immune terms (innate immune response, complement activation) appear, they are fewer and do not dominate the signal, suggesting development is the primary theme. Confidence: Medium","confidence":"","size":13,"edges":16,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0061551","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0090103","count":2}]},{"hash":"664733054476050133","title":"Neuronal synapse organization and innate immune signaling","description":"The top GO terms point to synapse assembly and postsynaptic density organization, supported by actin- and Rac-mediated cytoskeletal dynamics, alongside innate immune signaling and endocytosis regulation. This suggests a cluster of proteins involved in organizing synapses while also engaging immune-related pathways, with some overlap in endocytic trafficking.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0030032","count":3},{"id":"GO:0016601","count":3},{"id":"GO:0007416","count":3},{"id":"GO:0060348","count":3}]},{"hash":"1721666987277747771","title":"Unknown","description":"This cluster's top GO terms are highly diverse, including actin filament bundle assembly, spindle assembly, small GTPase signaling, various protein localizations (telomere, presynapse, chromosome), spermatid nucleus differentiation, and endocytic/pinocytosis regulation. There is no single coherent biological process or pathway tying these proteins together, so a concise, informative label is not apparent.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":7},{"id":"GO:0007289","count":7},{"id":"GO:0032088","count":7},{"id":"GO:0051225","count":7},{"id":"GO:0048549","count":7}]},{"hash":"781086787488008739","title":"STAT-driven signaling in muscle differentiation and immunity","description":"The top GO terms point to STAT pathway activation (tyrosine phosphorylation of STAT proteins) and processes tied to muscle lineage commitment (myoblast differentiation) as well as innate immune responses, with additional signals related to signaling pathways (e.g., NF-kappaB). This suggests a coherent theme around STAT-mediated signaling influencing both muscle differentiation and immune-related processes, hence a label focused on STAT-driven signaling in these contexts.","confidence":"Medium","size":13,"edges":30,"triangles":21,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042517","count":7},{"id":"GO:0045663","count":7},{"id":"GO:0042552","count":7},{"id":"GO:0014068","count":7},{"id":"GO:0045087","count":7}]},{"hash":"1141774352483317112","title":"Developmental signaling and morphogenesis","description":"The top GO terms cluster around embryonic development and signaling pathways: multiple entries for thymus development, metanephros development, forebrain morphogenesis, and multicellular organism development, plus regulatory terms like positive regulation of Wnt signaling, GTPase activity, and peptidyl-tyrosine phosphorylation. This points to a group of proteins involved in developmental signaling and tissue patterning, with some secondary associations to transport and cytoskeletal regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0007026","count":3},{"id":"GO:0046326","count":3}]},{"hash":"1665233819904711900","title":"Endosomal trafficking and cytoskeletal signaling","description":"The GO terms point to endosome transport (early-to-late, endosome-to-lysosome), ubiquitination, and small GTPase\u2013mediated signaling, coupled with actin dynamics (filopodium assembly) and ERK pathway regulation. This suggests a cohesive module coordinating membrane trafficking with cytoskeletal remodeling and signal transduction, rather than a single enzyme activity.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0003382","count":5},{"id":"GO:0008333","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0045022","count":5},{"id":"GO:0016567","count":5}]},{"hash":"1909611967408043762","title":"Placental Development and Birth-Related Processes","description":"The top GO terms strongly point to maternal reproductive biology, with placenta development and parturition being prominent. Mitochondrial outer membrane permeabilization suggests a role for apoptotic remodeling during placental formation, which can accompany birth-related processes. Endodermal differentiation hints at broader embryonic development context, though it\u2019s less central. Some terms (DNA integration, obsolete growth hormone regulation) are less informative for the cluster\u2019s main theme. Overall, the cluster centers on placental and birth-related biology with a possible apoptosis angle.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0097345","count":10},{"id":"GO:0001893","count":10},{"id":"GO:0060137","count":10},{"id":"GO:1903547","count":10},{"id":"GO:0015074","count":4}]},{"hash":"1830725550911499365","title":"mRNA splicing and translation initiation","description":"These proteins are strongly linked to mRNA processing and splicing (cis splicing, spliceosome, splice-site recognition, alternative splicing, processome assembly) and also to steps in initiating translation (preinitiation complex formation and assembly of the eIF4F complex), suggesting a shared role in RNA maturation and the onset of translation.","confidence":"High","size":13,"edges":3,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0006378","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0010610","count":6},{"id":"GO:0034462","count":5}]},{"hash":"1527425944967077858","title":"Migration and Peroxisome Localization","description":"This cluster features several migration-related processes (neuron, cerebral cortex, smooth muscle cell migration) alongside peroxisomal functions (protein import into peroxisomes, peroxisome localization, fatty acid alpha-oxidation), suggesting a set of proteins involved in cell movement with links to peroxisomal metabolism/trafficking. While growth signaling terms are present, the clearest shared theme is migration coupled with peroxisomal association.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001764","count":2},{"id":"GO:0048137","count":2},{"id":"GO:0016560","count":2},{"id":"GO:0060152","count":2},{"id":"GO:0001967","count":2}]},{"hash":"1552171535133848454","title":"Neuronal synapse formation and signaling","description":"This cluster is dominated by GO terms related to synapse assembly, excitatory signaling, and neurotransmitter secretion, as well as behavior-related terms like social and vocalization behavior. Taken together, these terms point to proteins involved in neural development and synaptic communication that can influence behavioral outputs. Some terms like apoptotic process and myoblast development appear, but the core theme remains neural synapse formation and signaling. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0051968","count":4},{"id":"GO:0035176","count":4},{"id":"GO:0071625","count":4},{"id":"GO:2000463","count":4}]},{"hash":"542403416287368","title":"Nuclear ribosome biogenesis and RNA export","description":"The top GO terms cluster around ribosome biogenesis and large subunit assembly, along with pre-replicative complex assembly in the nucleus and mRNA export from the nucleus, pointing to a coherent role in nuclear ribosome production and RNA trafficking. Some nucleotide metabolism terms are present but do not define the core theme of this cluster.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":3},{"id":"GO:0006267","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0045022","count":2},{"id":"GO:0010197","count":2}]},{"hash":"1809675061954241477","title":"Chromatin regulation and transcription control","description":"The top terms cluster around nuclear chromatin dynamics, transcription regulation, histone modification, and chromosome localization (e.g., negative regulation of transcription by RNA Pol I, regulation of histone methylation, establishment of protein localization to chromatin, telomere/chromosome regulation). This points to a coherent theme of epigenetic control and chromatin-based transcription processes.","confidence":"High","size":13,"edges":53,"triangles":112,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1904815","count":13},{"id":"GO:1901837","count":13},{"id":"GO:0034184","count":13},{"id":"GO:0033128","count":13},{"id":"GO:0070481","count":13}]},{"hash":"794921940815146503","title":"Organogenesis and mitochondrial function","description":"This cluster shows enrichment in organ development terms (heart/kidney/liver and muscle development) alongside mitochondrial-related terms (complex I assembly and electron transport), suggesting proteins involved in organogenesis with a mitochondrial/metabolic role. Translation and mRNA processing terms are present but appear more peripheral. The overall theme centers on development with a mitochondrial function component, though the link is not perfectly cohesive.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0032981","count":2},{"id":"GO:0055010","count":2},{"id":"GO:0001822","count":2}]},{"hash":"896104787343165505","title":"Developmental signaling and neural plasticity","description":"The top GO terms show skeletal and reproductive development (bone development, osteoblast fate commitment, uterus development) and axis specification, indicating broad developmental roles, while neural-function terms (synaptic depression, AMPA receptor clustering, fear/affect regulation) and innate immune notes suggest intertwined neurodevelopmental, neural signaling, and neuroimmune interactions. The cluster appears to combine developmental cues with neural regulation rather than a single pathway.","confidence":"Medium","size":13,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":5},{"id":"GO:0002051","count":4},{"id":"GO:0060065","count":4},{"id":"GO:0007352","count":3},{"id":"GO:0031666","count":3}]},{"hash":"637945457907188067","title":"Developmental differentiation and cell adhesion","description":"This cluster centers on tissue morphogenesis and cell differentiation across diverse lineages (immune, neural, renal/urinary, vascular) and features common cell-adhesion processes (homophilic and calcium-dependent adhesion, apical localization) plus aspects of organelle/membrane organization, suggesting a shared theme of developmental tissue organization rather than a single pathway.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002314","count":13},{"id":"GO:0097118","count":13},{"id":"GO:0060019","count":13},{"id":"GO:0072006","count":13},{"id":"GO:0045176","count":13}]},{"hash":"60299573641421222","title":"Embryonic organogenesis and neural development","description":"The terms point to broad embryonic development across multiple lineages, especially nervous system formation (neural crest, neuron specification, parasympathetic NS) and organogenesis (pituitary, semicircular canal, ureteric bud, septum development, somite formation). This suggests a shared role in early development rather than a single specific pathway, hence a general label of embryonic organogenesis with emphasis on neural development.","confidence":"Medium","size":13,"edges":28,"triangles":4,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001757","count":12},{"id":"GO:0014029","count":10},{"id":"GO:0021920","count":10},{"id":"GO:0021983","count":10},{"id":"GO:0045686","count":10}]},{"hash":"263046574316763560","title":"Glycolysis and carbohydrate catabolism","description":"Proteins in this cluster are enriched for canonical glycolysis, fructose-6-phosphate metabolism, and glycogen/glycogen-derived sugar breakdown, with supporting signals from storage-polysaccharide utilization and related NAD salvage pathways. This suggests a coherent module focused on energy production from sugars and sugar metabolism.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":4},{"id":"GO:0006002","count":4},{"id":"GO:0005980","count":4},{"id":"GO:0093001","count":4},{"id":"GO:0061621","count":4}]},{"hash":"1976807274877514451","title":"GPCR signaling and calcium mobilization in platelets and heart","description":"Most terms center on GPCR signaling and downstream effectors: activation of adenylate cyclase, regulation of GTPase activity, calcium mobilization, and phosphorylation, along with platelet activation and regulation of cardiac muscle contraction. The presence of inflammatory response and opsin-related signaling further supports a GPCR-centered signaling network across tissues. This combination suggests a cohesive GPCR-mediated pathway controlling calcium and cAMP in platelets and heart.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030168","count":9},{"id":"GO:0043547","count":9},{"id":"GO:0045745","count":9},{"id":"GO:0006954","count":9},{"id":"GO:0007190","count":9}]},{"hash":"1360900224796243745","title":"Neural Sensing and Thermoregulation","description":"The top GO terms cluster around neural signaling and sensory processing (sensory perception of pain, dopaminergic synaptic transmission) and temperature/energy-related responses (cellular response to temperature stimulus, diet-induced thermogenesis, eating behavior). Calcium signaling terms (release and regulation of sequestered calcium) further support a neuronal signaling theme. While some terms like phototransduction and eosinophil chemotaxis are broader, the dominant pattern is neural communication linked to sensory cues and thermogenic/energy balance. Confidence: Medium","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":10},{"id":"GO:0002024","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0048245","count":9}]},{"hash":"1133597160304038051","title":"Ubiquitin-Dependent Proteolysis and Signaling","description":"The enriched GO terms are dominated by ubiquitination-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, K6-linked ubiquitination) and signaling pathways tied to apoptosis and NF-\u03baB (I-kappaB phosphorylation, TNF signaling). This suggests the cluster groups proteins involved in ubiquitin-mediated protein turnover and signaling regulation, potentially modulating chromatin and immune responses as indicated by histone catabolic process and V(D)J recombination terms. Overall, the theme is ubiquitin-driven regulation of protein fate and cell signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:1901253","count":7},{"id":"GO:0033151","count":7},{"id":"GO:0051865","count":7},{"id":"GO:0085020","count":7}]},{"hash":"1618422020564658908","title":"Telomere maintenance regulators","description":"Top terms point to telomere biology\u2014shelterin complex assembly, telomere localization, and regulation of telomeric DNA structures\u2014with additional signals related to transcriptional regulation. This pattern suggests a cluster of proteins involved in telomere maintenance and regulation, rather than unrelated processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904792","count":2},{"id":"GO:1904911","count":2},{"id":"GO:1905839","count":2},{"id":"GO:0010520","count":2},{"id":"GO:1904850","count":2}]},{"hash":"1796777859238082558","title":"Developmental signaling and metabolism","description":"The terms cluster around tissue development (spinal cord, adipose, germ cells, myelination) and signaling pathways (PI3K/AKT, calcineurin-NFAT) with metabolic readouts (glucose response, adipose development). This suggests proteins involved in broad developmental signaling ties to metabolic regulation across tissues rather than a single tight function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":2},{"id":"GO:0043491","count":2},{"id":"GO:0014065","count":2},{"id":"GO:0031641","count":2},{"id":"GO:0051534","count":2}]},{"hash":"1505511130894394680","title":"Innate antiviral signaling and ubiquitination","description":"The proteins are enriched for innate immune and antiviral defense terms (innate immune response, defense response to virus, Toll signaling, Th1-type immune response) along with ubiquitin-related processes (protein ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination, K6-linked ubiquitination) and related chromatin turnover (histone catabolic process). This suggests a cohesive module where ubiquitin signaling modulates antiviral innate responses and downstream transcriptional programs. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":6},{"id":"GO:0042787","count":5},{"id":"GO:0016567","count":4},{"id":"GO:0051865","count":4}]},{"hash":"68469888709273766","title":"Neural development, myelination, and synapse formation","description":"The cluster shows strong signals for neural-related processes: myelination, axonal fasciculation, and positive regulation of synapse assembly, pointing to neural development and connectivity. Otolith morphogenesis and sensory-linked transcriptional regulation further support a neural/sensory development theme, while a few terms (viral process, shelterin assembly) are less coherent with the main signal. Overall, the dominant pattern aligns with neuron maturation and synaptic organization.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902499","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1072446402060536792","title":"Signaling Regulation and Transcription Control","description":"The cluster shows terms for transcriptional regulation, receptor recycling/endosome regulation, and multiple signaling pathways (Rho, TLR4/MyD88) along with neural synaptic transmission, suggesting a module that ties gene expression control to dynamic signaling and trafficking in response to stimuli. Confidence: Medium","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0051291","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0051036","count":2}]},{"hash":"357484668410048006","title":"cAMP-Driven Signaling and Transcription Regulation","description":"The cluster shows strong enrichment for cAMP-related signaling (cAMP biosynthetic process, adenylate cyclase-activating receptor signaling, forskolin response) and cytoplasmic signal transduction, coupled with regulation of DNA-templated transcription. This suggests proteins that link GPCR/adenylyl cyclase\u2013mediated signaling to transcriptional changes, with additional hints of blue-light and hypoxia-responsive pathways contributing to the broader signaling context.","confidence":"High","size":12,"edges":20,"triangles":2,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0032026","count":6},{"id":"GO:0006355","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0070483","count":5},{"id":"GO:1904322","count":5}]},{"hash":"629548148787502610","title":"Developmental and immune signaling","description":"The cluster centers on diverse signaling pathways rather than a single process: GM-CSF and prostaglandin stimuli (immune/inflammatory), T cell receptor signaling, IL-4 production, and Wnt signaling, with links to growth hormone/insulin signaling and heart development, and keratinocyte differentiation. Together these GO terms suggest a module of cross-talking signaling processes involved in immune responses and tissue development, rather than a single specialized function.","confidence":"Medium","size":12,"edges":9,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097011","count":11},{"id":"GO:0071380","count":10},{"id":"GO:0050852","count":10},{"id":"GO:0046626","count":10},{"id":"GO:0060396","count":10}]},{"hash":"1093215245014478336","title":"Glycan biosynthesis and glycosylation","description":"The GO terms cluster around glycan biosynthesis and glycosylation (poly-N-acetyllactosamine, mucilage, Lewis a epitope, O-linked hydroxyproline glycosylation) and tie to cell-surface and developmental processes (adhesion, polarity, epidermal/epithelial development), suggesting a shared theme of glycan modifications shaping development and cell interactions.","confidence":"High","size":12,"edges":43,"triangles":59,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0030311","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0075015","count":3}]},{"hash":"847098554374909411","title":"Chromatin organization and chromosome maintenance","description":"These proteins are enriched for chromatin-related processes: nucleosome mobilization, heterochromatin formation, localization to chromatin, and regulation of transcription by RNA Pol II and I, as well as cohesion and sister-chromatid maintenance. A few terms are unrelated or species-specific (e.g., plasmid partitioning or gonad development), but the dominant signal points to chromatin organization and chromosome maintenance.","confidence":"High","size":12,"edges":26,"triangles":44,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042766","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0031508","count":4},{"id":"GO:0071169","count":4},{"id":"GO:0016584","count":3}]},{"hash":"1028740521615835527","title":"Unknown","description":"The top GO terms span neuronal and organ morphogenesis, epithelial tissue proliferation, immune signaling, lipid metabolism, and DNA repair, with no single unifying function tying all terms together. The cluster appears to include diverse roles across development, signaling, and genome maintenance, making a coherent, specific label difficult. ","confidence":"","size":12,"edges":39,"triangles":42,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":8},{"id":"GO:1990804","count":8},{"id":"GO:0033598","count":8},{"id":"GO:0002688","count":8},{"id":"GO:0071380","count":8}]},{"hash":"1283801635738167056","title":"MAPK-regulated neuronal development and synaptic signaling","description":"The top GO terms point strongly to MAPK pathway regulation (ERK/JNK cascades) together with nervous system development, dendrite morphogenesis, and excitatory synaptic activity, suggesting a cluster of proteins coordinating neuronal growth and synaptic signaling via MAPK signaling. Some terms like mitotic cell cycle or T cell signaling may reflect shared signaling components, but the core theme remains MAPK-driven neuronal development and synaptic function.","confidence":"High","size":12,"edges":5,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0070374","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0046330","count":7}]},{"hash":"846307156108218082","title":"Neural Sensory Perception and Drug Response","description":"The cluster shows strong representation of visual and pain perception, dopaminergic synaptic transmission, learning, and drug-related behavioral responses (cocaine, morphine), along with ERK signaling; together, these terms point to neural circuits underlying sensory processing and drug-induced behaviors.","confidence":"High","size":12,"edges":56,"triangles":138,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0071380","count":7},{"id":"GO:0043278","count":7},{"id":"GO:0002035","count":7}]},{"hash":"2206092687319940537","title":"Neuroimmune Axonogenesis Signaling","description":"These GO terms cluster around neural development and immune signaling: there is emphasis on neurogenesis and axonogenesis, regulation of axon extension and paranode localization, together with immune and receptor tyrosine kinase signaling (Th2 cytokine production, IL-27 signaling, and STAT phosphorylation). This pattern suggests a module where immune signals interface with neural development and axon growth via RTK-STAT pathways. Confidence: Medium","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035745","count":9},{"id":"GO:0070106","count":9},{"id":"GO:0042517","count":9},{"id":"GO:0048692","count":8},{"id":"GO:1902997","count":8}]},{"hash":"1687994693777216337","title":"Golgi- and SNARE-mediated synaptic vesicle trafficking","description":"The top GO terms cluster around Golgi ribbon formation and vesicle trafficking involving the Golgi and ER, SNARE complex assembly, and exocytic insertion of neurotransmitter receptors at the postsynaptic membrane, with related cues from norepinephrine secretion and synaptic potentiation. This suggests a coherent theme of Golgi- and SNARE-dependent vesicle trafficking and regulated neurotransmission at the synapse.","confidence":"High","size":12,"edges":24,"triangles":16,"max_degree":11,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0090161","count":11},{"id":"GO:0048280","count":11},{"id":"GO:0006891","count":11},{"id":"GO:0006888","count":11},{"id":"GO:0060291","count":10}]},{"hash":"1401730372533254658","title":"Actin cytoskeleton remodeling & cell motility signaling","description":"The cluster is dominated by GO terms for filopodium assembly and its regulation, plus small GTPase-mediated signaling and processes related to cell spreading and cytoskeletal dynamics. This points to a cohesive theme of actin cytoskeleton remodeling driving cell movement, adhesion, and shape changes across diverse cell types (platelets, neurons, immune cells), with some involvement in organelle dynamics like mitochondrial fission.","confidence":"High","size":12,"edges":10,"triangles":0,"max_degree":10,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0046847","count":8},{"id":"GO:0007264","count":8},{"id":"GO:0051489","count":8},{"id":"GO:0045792","count":8},{"id":"GO:0000266","count":8}]},{"hash":"77551419395278899","title":"Multitissue Development and Differentiation","description":"The top GO terms point to developmental and differentiation processes across diverse tissues (muscle, nervous system, kidney, uterine epithelium), including axonogenesis, muscle differentiation, organ morphogenesis, and related proliferative regulation. While not tied to a single tissue, they collectively reflect cross-tissue developmental programs supported by common cellular processes like transcription and exocytosis. This makes a cross-tissue development theme the most representative label.","confidence":"Medium","size":12,"edges":55,"triangles":130,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:2000346","count":5},{"id":"GO:0046013","count":5},{"id":"GO:2000691","count":5},{"id":"GO:0035995","count":5},{"id":"GO:0030579","count":5}]},{"hash":"1421323484752265251","title":"Fructose and Gluconeogenesis Metabolism","description":"The cluster is centered on carbohydrate metabolism, with multiple GO terms for fructose metabolism, gluconeogenesis, and related pathways (fructose 6-phosphate metabolism, fructose 1,6-bisphosphate metabolism, and regulation of gluconeogenesis). This points to a shared function in energy homeostasis through carbohydrate processing. Some terms (like protein homotetramerization and cellular response to xenobiotic stimulus) are less directly tied to core metabolism and may reflect broader or ancillary roles.","confidence":"High","size":12,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006094","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0051289","count":3},{"id":"GO:0006002","count":2},{"id":"GO:0042149","count":2}]},{"hash":"1544517881463469310","title":"Neural development and synaptic signaling","description":"These proteins are enriched for brain-related development and neuronal function: hippocampus and substantia nigra development, dendrite morphogenesis, and regulation of long-term synaptic plasticity, along with signaling pathways like ERK and Wnt that drive neuronal differentiation and connectivity. The endothelial barrier term may reflect neurovascular development, but the dominant theme is neural development and synaptic signaling.","confidence":"High","size":12,"edges":7,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0061028","count":4},{"id":"GO:0048169","count":4},{"id":"GO:0021762","count":4},{"id":"GO:0043525","count":3}]},{"hash":"1016161935662950627","title":"Insect developmental signaling and ER proteolysis","description":"The GO terms point to insect development and signaling: EGFR ligand maturation, wing and eye cell fate specification, and spermatid differentiation, plus a link to membrane proteolysis involved in ER-to-cytosol transport and unfolded-protein response. Some metabolic terms appear incidental. Overall, the cluster seems to group proteins involved in developmental signaling with ER proteolysis in insects.","confidence":"Medium","size":12,"edges":12,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1904211","count":3},{"id":"GO:0048515","count":3},{"id":"GO:0038005","count":3},{"id":"GO:0042676","count":3},{"id":"GO:0032815","count":3}]},{"hash":"1826047833834746581","title":"Mitochondrial Import and Respiratory Chain Assembly","description":"This cluster is dominated by GO terms related to mitochondria: outer membrane organization, outer membrane translocase complex assembly, mitochondrial protein import, and components of the respiratory chain (NADH to ubiquinone, complex II assembly). While a few terms (e.g., certain biosynthetic or obsolete terms) are unrelated, the overall pattern points to mitochondrial biogenesis and respiration, suggesting the proteins function together in mitochondrial import and electron transport. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006728","count":1},{"id":"GO:0006729","count":1},{"id":"GO:0008616","count":1},{"id":"GO:0060821","count":1},{"id":"GO:0007008","count":1}]},{"hash":"1630219290795570238","title":"Mitochondrial and peroxisomal metabolism with apoptosis control","description":"The cluster is enriched for metabolic and catabolic GO terms tied to energy pathways (propionyl-CoA biosynthesis; L-isoleucine catabolic; ketone body catabolic; 3,4-dihydroxybenzoate catabolic) and for regulatory terms related to mitochondrial membrane permeability and apoptotic signaling, pointing to a theme of mitochondrial/peroxisomal metabolism linked to cell survival. Developmental terms (liver and kidney) may reflect tissue-specific expression but do not redefine the core metabolic/apoptotic pattern.","confidence":"Medium","size":12,"edges":34,"triangles":37,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":5},{"id":"GO:0032385","count":4},{"id":"GO:1902109","count":4},{"id":"GO:0010111","count":4},{"id":"GO:0072229","count":4}]},{"hash":"1735368640378599739","title":"Renal ion transport and water handling","description":"The cluster\u2019s top GO terms center on transmembrane transport of ions and small molecules (potassium, urea, acetate, carbon dioxide) and water absorption, plus kidney-related development (metanephric collecting duct) and renal functions. While there are some unrelated terms (e.g., pancreatic juice secretion, metal ion responses), the dominant pattern ties to kidney ion and water transport. ","confidence":"Medium","size":12,"edges":16,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0015840","count":4},{"id":"GO:0071288","count":4},{"id":"GO:0006846","count":4},{"id":"GO:0035378","count":4}]},{"hash":"2133483540813843478","title":"Mitochondrial lipid remodeling and phospholipid biosynthesis","description":"This cluster centers on lipid metabolism and mitochondrial membrane biology, with terms like cardiolipin remodeling, phosphatidylcholine and ether lipid biosynthesis, PC remodeling, and PAF biosynthesis, plus mitochondrial ATP synthesis linked to membrane function. Developmental terms appear peripheral; the lipid remodeling theme best ties the proteins together.","confidence":"Medium","size":12,"edges":22,"triangles":12,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042775","count":7},{"id":"GO:0021587","count":7},{"id":"GO:0070236","count":7},{"id":"GO:0016024","count":7},{"id":"GO:0002071","count":7}]},{"hash":"2006069034809907461","title":"Developmental Differentiation and Cytoskeleton Remodeling","description":"The cluster shows enrichment for myoblast differentiation and actin cytoskeleton reorganization, suggesting roles in developmental differentiation linked to cytoskeletal dynamics. Additional terms like translation and various organ development (lung) support a broad developmental theme, while immune and neural terms are present but less central. Overall, the common thread appears to be developmental processes intertwined with cytoskeletal remodeling.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045445","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0030324","count":2}]},{"hash":"1931185171664842739","title":"Mitochondrial stress and apoptosis","description":"The top GO terms point to mitochondrial depolarization, outer membrane permeabilization in apoptotic signaling, and mitophagy/autophagy of mitochondria, with supporting hints from ATP metabolism and heme biosynthesis that depend on mitochondrial functions. Together these suggest a theme of mitochondrial stress response coordinating energy regulation and programmed cell death. A couple of terms about blood cell differentiation reflect broader mitochondrial-associated processes but do not override the core mitochondria\u2013apoptosis motif.","confidence":"Medium","size":12,"edges":12,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1904925","count":1},{"id":"GO:1901030","count":1},{"id":"GO:1903578","count":1},{"id":"GO:0032780","count":1},{"id":"GO:0006783","count":1}]},{"hash":"1571963221588407465","title":"Placental Stress and Apoptosis","description":"The top terms blend placental biology (placenta development, parturition) with cellular stress and apoptosis indicators (mitochondrial outer membrane permeabilization, hypoxia response, DNA damage signaling, ubiquitination) and cytoskeletal remodeling (Arp2/3). This suggests a cohesive theme of placental tissue responding to stress through remodeling and programmed cell death pathways, rather than a single, narrow function. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097345","count":7},{"id":"GO:0060137","count":7},{"id":"GO:0001893","count":7},{"id":"GO:1903547","count":7},{"id":"GO:0015074","count":3}]},{"hash":"152772341704559173","title":"Multisystem Development and Differentiation","description":"The top terms show a focus on tissue and cell fate specification across different organ systems (myoblast fate and fusion, mesenchyme development, sinoatrial node differentiation, stomatal development) along with core transcriptional activity (RNA Pol II). This pattern points to general developmental differentiation programs rather than a single organ-specific pathway, spanning multiple kingdoms. ","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:2000820","count":12},{"id":"GO:0060921","count":11},{"id":"GO:0010374","count":11},{"id":"GO:0035481","count":11},{"id":"GO:2000763","count":11}]},{"hash":"1979390639831327452","title":"Innate Immune Signaling and Phagocytosis","description":"The cluster is dominated by GO terms tied to innate immune responses and phagocytic processes (innate immune response, defense against bacteria, Fc-gamma receptor signaling in phagocytosis, detection of peptidoglycan, immunoglobulin production, NK tolerance, virion attachment). These terms suggest a cohesive theme of innate immune recognition and antibody-mediated defense, with a single outlier term for atrial cardiac muscle action potential that is likely not representative of the main function. ","confidence":"Medium","size":12,"edges":50,"triangles":90,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0042742","count":4},{"id":"GO:0038096","count":4},{"id":"GO:0086014","count":4},{"id":"GO:0002519","count":4}]},{"hash":"588548269441368781","title":"GABAergic and Glutamatergic Neurotransmission with Taste","description":"This cluster is dominated by terms related to neural signaling and sensory perception, including GABA and glutamate pathways, taste detection (sweet), and related behaviors (locomotion, conditioned taste aversion) along with synaptic transmission and calcium signaling. Immune-related terms appear incidental and do not define the main theme.","confidence":"Medium","size":12,"edges":53,"triangles":118,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":8},{"id":"GO:0001661","count":7},{"id":"GO:0007214","count":7},{"id":"GO:0001582","count":6},{"id":"GO:0007196","count":6}]},{"hash":"2247992946440567077","title":"Unknown","description":"The top GO terms span neuron development, actin cytoskeleton dynamics, general transcription, ubiquitination, ribosome maturation, and stress responses, with no clear single biological theme tying all proteins together. Annotation noise (obsolete terms) further obscures a coherent function, so a specific label isn\u2019t justifiable.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0034314","count":1},{"id":"GO:0071456","count":1}]},{"hash":"343599348176358325","title":"Dendritic Spine Morphogenesis and Neuronal Signaling","description":"It includes positive regulation of dendritic spine development and morphogenesis, hippocampus development, and signaling pathways (Wnt, small GTPases), plus endocytosis and ruffle assembly, consistent with neuronal cytoskeletal remodeling and synapse maturation.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0006897","count":2}]},{"hash":"1078324736034976526","title":"Dopaminergic GPCR Signaling","description":"The top GO terms center on dopaminergic synaptic transmission, feeding behavior, and sensitization, indicating dopamine-driven neural signaling. The GPCR signaling and cGMP-related terms reinforce a focal theme of GPCR-mediated signaling in neurons. Other terms like renin regulation, heat generation, and vascular permeability suggest broader metabolic and endocrine roles of GPCR pathways, while some items (defense against bacteria) may reflect peripheral or context-specific functions. Overall, the cluster appears to represent a dopaminergic GPCR signaling module with associated metabolic and vascular contexts.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":12},{"id":"GO:0042755","count":12},{"id":"GO:0001963","count":12},{"id":"GO:0007199","count":12},{"id":"GO:1900134","count":12}]},{"hash":"55022228670616755","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006620","count":4},{"id":"GO:0051083","count":4},{"id":"GO:0008380","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0016567","count":2}]},{"hash":"2176847163924649327","title":"Chromatin regulation and genome maintenance","description":"The top GO terms cluster around nuclear processes: establishment of protein localization to chromatin, negative regulation of transcription by RNA polymerase II, single strand break repair, and positive regulation of DNA topoisomerase activity, which together point to chromatin regulation and genome maintenance. Additional terms such as cellular response to lipopolysaccharide and apoptotic phosphatidylserine exposure suggest potential multifunctional roles or secondary pathways, but the core signature remains nuclear chromatin regulation and DNA repair. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0033153","count":2},{"id":"GO:0000012","count":2},{"id":"GO:0071222","count":2}]},{"hash":"966512104246615365","title":"Embryonic Eye and Lung Morphogenesis","description":"The top GO terms cluster strongly around embryonic development and organ morphogenesis, especially eye development and lung morphogenesis, with terms like embryonic eye morphogenesis, camera-type eye development, and epithelial tube branching in lung morphogenesis. Transcription by RNA polymerase II and other regulatory terms accompany these processes, indicating transcriptional control during development. Some immune-related terms (T cell regulation in thymus) appear but do not dominate the signal; overall, the cluster centers on embryonic morphogenesis of sensory organs and lungs with transcriptional regulation.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":9},{"id":"GO:0006366","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0043010","count":9},{"id":"GO:0001701","count":7}]},{"hash":"1356590378030671809","title":"Xenobiotic response and transport","description":"Based on the top GO terms, the cluster centers on responding to xenobiotic stimuli and transporting diverse small molecules, including phospholipids, methionine, molybdate, and oligopeptides from mitochondria. While there are a couple of immune-related terms (dendritic cell differentiation) that are less frequent, the strongest signals tie to xenobiotic response and molecule transport, supporting a label for proteins involved in stress response and transport across membranes.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0032516","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0072089","count":1},{"id":"GO:0060702","count":1}]},{"hash":"1128790154383281353","title":"Diverse cellular responses to stimuli and nutrients","description":"This cluster's top GO terms cluster around responses to a variety of stimuli and metabolic cues (progesterone, ethanol, amino acids, calcium, glucose, lipids, hypoxia), as well as neuronal migration and apoptotic signaling context. The terms point to a broad set of cellular responsiveness rather than a single, cohesive pathway, so a label describing diverse stimulus/nutrient responses is most appropriate.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032570","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0045918","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0001764","count":2}]},{"hash":"1166979965846513002","title":"Glutamatergic and GABAergic synaptic transmission","description":"The top GO terms center on glutamatergic transmission, GABA signaling, excitatory postsynaptic potential, and receptor internalization, with accompanying sodium and potassium ion transport, all indicating a cluster of proteins involved in both excitatory and inhibitory synaptic signaling and ion flux at synapses. Behavioral terms like locomotory behavior and conditioned taste aversion further reflect neural activity linked to movement and behavior.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":6},{"id":"GO:0035725","count":5},{"id":"GO:0001661","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0060079","count":5}]},{"hash":"818318687174306668","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000245","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0000278","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0042273","count":1}]},{"hash":"2044519629270213022","title":"Developmental Patterning and Organ Morphogenesis","description":"Based on the GO terms, the strongest signals are in developmental patterning and organ morphogenesis, with left/right pattern formation, midbrain development, and pancreas morphogenesis pointing to a developmental program. Additional terms related to transcription regulation and tissue remodeling/coagulation may reflect broader or pleiotropic roles, but the dominant theme is developmental patterning. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0060972","count":3},{"id":"GO:0060309","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0032496","count":3}]},{"hash":"199772252227971147","title":"Vertebrate organogenesis and tissue patterning","description":"The top GO terms revolve around development of multiple organs and tissues (kidney branching and metanephric development, vasculogenesis, left/right asymmetry, odontogenesis, labial disc, genitalia development) with additional neuropeptide signaling; there isn\u2019t a single pathway but a cohesive theme of embryonic organ formation and patterning across different tissues. This makes \"Vertebrate organogenesis and tissue patterning\" a concise, representative label.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":2},{"id":"GO:0051795","count":2},{"id":"GO:0001658","count":2},{"id":"GO:0072136","count":2},{"id":"GO:0001570","count":2}]},{"hash":"711740920013115539","title":"Rho GTPase-driven epithelial polarity and migration","description":"The top GO terms cluster around small GTPase signaling, establishment of epithelial cell polarity, actin filament bundle assembly, and cell migration, with supporting EGFR signaling. This suggests a cohesive role in coordinating cytoskeletal remodeling and polarity in epithelial cells, relevant to morphogenesis and motility.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0007173","count":3}]},{"hash":"1554586102463725591","title":"Histone acetylation and developmental transcription regulation","description":"This cluster is driven by GO terms for histone acetylation (H4 and H3) and regulation of DNA-templated transcription, complemented by development-related processes such as imaginal disc fusion, thorax closure, and sensory organ precursor fate. The combination suggests chromatin modification controlling developmental gene expression, with additional links to heat and mechanical stress responses that can modulate developmental pathways.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043981","count":4},{"id":"GO:0043982","count":4},{"id":"GO:0043966","count":4},{"id":"GO:0009408","count":4},{"id":"GO:0071260","count":4}]},{"hash":"1870943676277825657","title":"Dopaminergic GPCR signaling and neuroendocrine regulation","description":"The top GO terms are centered on dopaminergic synaptic transmission and GPCR signaling (including GPCR\u2192cGMP pathways) and relate to behaviors like eating and sensitization, pointing to a dopamine-driven neural signaling theme. Additional terms touch on neuroendocrine and physiological processes (e.g., vascular/permeability regulation, renin-related regulation), suggesting broader GPCR-mediated effects. Taken together, the cluster seems to represent dopamine-associated GPCR signaling with downstream neuroendocrine and systemic roles.","confidence":"Medium","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":12},{"id":"GO:0042755","count":12},{"id":"GO:0001963","count":12},{"id":"GO:0007199","count":12},{"id":"GO:1900134","count":12}]},{"hash":"529522841961352992","title":"Neural development and morphogenesis","description":"In this cluster, the strongest GO terms are forebrain development, neural tube closure, and neural crest cell migration, which collectively point to neural development and early nervous system morphogenesis. Supporting terms like Rho signaling, vesicle transport between ER and Golgi, and transcriptional/post-translational regulation further align with cellular processes that drive tissue morphogenesis during development. While a few terms touch on broader developmental processes, the dominant theme is neural development.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0070262","count":3}]},{"hash":"2199734472269391943","title":"Unknown","description":"The terms span epithelial polarity, apoptotic processes in liver and myeloid cells, calcium signaling, telomere maintenance/localization, and cardiac conduction. There is no single shared function tying all items together, so a cohesive functional label cannot be determined.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":9},{"id":"GO:0097284","count":9},{"id":"GO:0016477","count":9},{"id":"GO:0051209","count":9},{"id":"GO:0033028","count":9}]},{"hash":"646162621647176622","title":"Ubiquitin-Mediated Immune Signaling","description":"The GO terms cluster around ubiquitin-dependent protein turnover and immune signaling, including innate antiviral defense, NF-\u03baB and JNK pathway regulation, and even V(D)J recombination. This points to a cohesive role in ubiquitin-regulated immune responses, spanning innate and adaptive immunity.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0051607","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0030433","count":6},{"id":"GO:1903762","count":5}]},{"hash":"1924944355435391770","title":"Heart development and cardiac contraction regulation","description":"The top GO terms point to heart development and regulation of cardiac muscle contraction (with both positive and negative regulation of heart contraction), plus related cardiovascular smooth muscle relaxation and intracellular signaling, suggesting a cluster centered on cardiovascular development and heart function. Some terms about fat cell and chondrocyte differentiation, and Wnt signaling, indicate broader mesodermal differentiation, but the strongest signal is heart-related, justifying this label.","confidence":"High","size":11,"edges":17,"triangles":10,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0045444","count":4},{"id":"GO:0060452","count":3},{"id":"GO:0003108","count":3},{"id":"GO:0031914","count":3}]},{"hash":"613954441386981196","title":"Developmental and immune signaling pathways","description":"The proteins in this cluster participate in multiple signaling pathways (Roundabout/ROBO, T cell receptor, Hedgehog/Smoothened, IL-27, ERK cascade, STAT phosphorylation) and relate to developmental processes (nervous system and kidney development, bone ossification). The unifying theme is diverse signaling cascades that coordinate development and immune signaling, rather than a single pathway.","confidence":"Medium","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0001822","count":7},{"id":"GO:0007224","count":7}]},{"hash":"467599569549598467","title":"Myogenesis and Heart Development","description":"The top GO terms cluster around muscle formation and cardiac/mesenchymal development (myoblast fate determination, myoblast fusion, branchiomeric skeletal muscle development, sinoatrial node differentiation, mesenchyme development, heart-related transcription). While a few terms are tangential (e.g., stomatal development, obsolete notes), the dominant pattern points to proteins involved in muscle differentiation and heart/cardiac-associated formation, including cranial muscle lineages.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060921","count":11},{"id":"GO:0010374","count":11},{"id":"GO:0035481","count":11},{"id":"GO:2000763","count":11},{"id":"GO:0060485","count":11}]},{"hash":"148849221928589651","title":"Developmental Pathways and Stress Responses","description":"The top GO terms show clear emphasis on developmental processes (neural tube closure, forebrain development, skeletal system development, and multicellular organism development). Other terms reflect cellular stress and immune responses (cadmium ion response, ER stress-related apoptotic signaling, defense response to Gram-positive bacteria), suggesting a developmental core with accompanying stress signaling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001843","count":8},{"id":"GO:0071276","count":6},{"id":"GO:0001403","count":6},{"id":"GO:0006349","count":6},{"id":"GO:0007275","count":6}]},{"hash":"1255146315473026704","title":"Amino acid and osmolyte membrane transport","description":"These proteins share GO terms indicating transmembrane transport of amino acids (e.g., L-ornithine, L-arginine, D-alanine), polyamines, GABA, and carnitine, along with related osmotic balance terms (cell volume homeostasis, hypotonic salinity response). The recurrent theme is transport across the plasma membrane for small molecules, consistent with solute carriers or transporter proteins. An obsolete rubidium transport term aligns with the ion transport theme. Overall, the cluster appears to be amino acid and osmolyte membrane transport.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006884","count":3},{"id":"GO:1902269","count":3},{"id":"GO:0097640","count":3},{"id":"GO:0071477","count":3},{"id":"GO:0042941","count":3}]},{"hash":"835448581229766701","title":"Developmental morphogenesis and signaling","description":"Top GO terms indicate a focus on tissue morphogenesis (dendrite morphogenesis, outer ear morphogenesis, mammary gland epithelial cell proliferation) and signaling responses (prostaglandin E stimulus, phorbol ester response) as well as cyclic nucleotide biosynthetic processes. This suggests the proteins collectively participate in developmental patterning and signaling pathways, with some non-core terms like DNA repair and sterol import being less central or reflective of multifunctionality. Therefore, the label highlights the developmental and signaling theme within the cluster.","confidence":"Medium","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":8},{"id":"GO:1990804","count":8},{"id":"GO:0033598","count":8},{"id":"GO:0002688","count":8},{"id":"GO:0071380","count":8}]},{"hash":"1663575203261554508","title":"Neuronal axon development and signaling regulators","description":"The GO terms cluster around axonogenesis and neurogenesis, with both positive and negative regulation of axon extension, plus axon-associated localization and signaling pathways (RTK, PI3K/AKT, BMP). This suggests proteins coordinating neuronal morphogenesis and axon growth/ signaling, despite one outlier term, so the label captures the central theme.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048692","count":5},{"id":"GO:1902997","count":5},{"id":"GO:0050772","count":5},{"id":"GO:0050925","count":5},{"id":"GO:0007169","count":5}]},{"hash":"2095465726154499980","title":"Developmental differentiation and reproductive maturation","description":"This cluster\u2019s top GO terms center on development and lineage differentiation across tissues (stem cell proliferation, megakaryocyte/erythrocyte differentiation, embryonic and pituitary development) and on reproductive processes (sperm capacitation). Together they point to broad developmental regulation and maturation across cell types, with some peripheral metabolic terms. Confidence: Medium","confidence":"","size":11,"edges":44,"triangles":85,"max_degree":10,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:2000648","count":8},{"id":"GO:0043046","count":7},{"id":"GO:0045654","count":7},{"id":"GO:0021983","count":6},{"id":"GO:0045648","count":6}]},{"hash":"2069242849225485798","title":"Dendritic spine morphogenesis and AMPA receptor clustering","description":"This cluster centers on postsynaptic structure and synaptic plasticity, with terms like dendritic spine morphogenesis, AMPA receptor clustering, and postsynaptic density assembly signaling spine formation and receptor organization. Long-term synaptic depression and behavioral terms (social behavior, fear regulation) imply functional plasticity affecting behavior, while Rac pathway regulation ties to actin remodeling in spines. Apoptotic process is less central here. Overall, the proteins appear linked to dendritic spine development and AMPA receptor\u2013mediated plasticity with behavioral implications.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0031666","count":2},{"id":"GO:0060292","count":2},{"id":"GO:2000822","count":2},{"id":"GO:1904717","count":2}]},{"hash":"1323741185473895967","title":"Arp2/3-Mediated Actin Nucleation and Cytoskeleton Regulation","description":"Based on the prominent presence of Arp2/3 complex\u2013mediated actin nucleation terms, plus barbed-end actin filament capping and regulation of actin dynamics, the cluster appears centered on actin cytoskeleton remodeling. Some related GO terms (neuron projection development, osteoblast differentiation) reflect actin-driven morphogenesis, and GPCR signaling may connect to cytoskeletal control, but the core signal remains actin nucleation/regulation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007200","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0016575","count":3}]},{"hash":"1082978831582533816","title":"Amino acid biosynthesis and catabolism","description":"The top GO terms are all amino acid metabolic processes, mainly biosynthesis for several amino acids (isoleucine, threonine, tryptophan, D-serine, cysteine) and a general amine catabolic process, indicating a cohesive theme of amino acid metabolism. Some terms are obsolete, but the overall signal points to proteins functioning in amino acid synthesis and degradation.","confidence":"High","size":11,"edges":16,"triangles":17,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009097","count":6},{"id":"GO:0046360","count":6},{"id":"GO:0009088","count":6},{"id":"GO:0018871","count":6},{"id":"GO:0019343","count":6}]},{"hash":"629465384608559216","title":"Oxidative stress and nitric oxide metabolism","description":"Dominant GO terms point to redox biology: response to toxic substances, superoxide generation, and both nitric oxide biosynthesis and catabolic processes, indicating a cluster centered on oxidative stress responses and NO metabolism. While there are a few other metabolic or gene expression terms present, the core theme ties to reactive oxygen/nitrogen species signaling and detoxification.","confidence":"High","size":11,"edges":18,"triangles":9,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":9},{"id":"GO:0055114","count":7},{"id":"GO:0045429","count":7},{"id":"GO:0010124","count":6},{"id":"GO:0010467","count":6}]},{"hash":"703424620642030049","title":"Unknown","description":"The GO terms cover a wide and inconsistent set of processes (neural vesicle endocytosis, ubiquitination, plant tropisms, immune signaling, sarcomere organization, renal ion transport, T cell differentiation), with no clear shared function among the proteins. There is no single theme that unites these terms into a coherent cluster label.","confidence":"","size":11,"edges":19,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:1990390","count":3},{"id":"GO:0009638","count":3},{"id":"GO:0032764","count":3},{"id":"GO:0045214","count":3}]},{"hash":"842913510538859216","title":"Spliceosome-Mediated mRNA Processing and Translation Initiation","description":"The cluster is dominated by GO terms for mRNA splicing and spliceosome assembly (including regulatory and alternative splicing), processing steps like small-subunit processome assembly and splice-site recognition, and terms related to forming translation preinitiation complexes, suggesting a cohesive theme around mRNA maturation coupled with initiation of translation.","confidence":"High","size":11,"edges":8,"triangles":2,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":8},{"id":"GO:0031047","count":8},{"id":"GO:0006378","count":7},{"id":"GO:0045292","count":6},{"id":"GO:0034462","count":6}]},{"hash":"173656051025678779","title":"Mitochondrial Metabolite Transport","description":"The major GO terms point to transport of metabolites into and across mitochondrial membranes and within mitochondrial metabolic shuttles, including iron import into mitochondria, alpha-ketoglutarate and glycine transport, ornithine transport, and the malate-aspartate shuttle, plus ATP transmembrane transport. This converges on a cohesive theme of mitochondrial metabolite exchange and energy metabolism, with a few ancillary signals related to stress responses. Confidence in this thematic label is High.","confidence":"High","size":11,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060546","count":3},{"id":"GO:0048250","count":2},{"id":"GO:0036233","count":2},{"id":"GO:0000066","count":2},{"id":"GO:0015742","count":2}]},{"hash":"10497140607116861","title":"Unknown","description":"The GO terms span very different biological areas (protein turnover/ubiquitin recycling and proteolysis, protein oligomerization, membrane transport, insulin signaling, hormonal and protein catabolism, plus viral and symbiont interactions). This lack of a cohesive single function or pathway makes it hard to assign a specific, concise label, so Unknown is appropriate.","confidence":"","size":11,"edges":34,"triangles":47,"max_degree":10,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0032461","count":3},{"id":"GO:0010992","count":3},{"id":"GO:0071432","count":3},{"id":"GO:0045861","count":3},{"id":"GO:1902600","count":3}]},{"hash":"906699983874039634","title":"Endomembrane trafficking and ESCRT sorting","description":"The dominant GO terms point to retrograde and vesicle-mediated transport between endosomes, Golgi, and ER, plus multivesicular body assembly/sorting and ubiquitin-dependent degradation via the MVB pathway, which together define endomembrane trafficking and ESCRT-mediated sorting. Actin polymerization may support vesicle movement, while the nuclear terms appear as ancillary processes; overall the theme centers on cargo transport and sorting within the endomembrane system.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042147","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0030041","count":2},{"id":"GO:0032508","count":2}]},{"hash":"67176432448341456","title":"Neuronal excitability and cerebellar development","description":"The top GO terms are dominated by neuronal signaling and electrical activity: neuronal action potential, startle response, cerebellar molecular layer development, and membrane repolarization, plus potassium ion transport (export/import). These together point to a neural/electrophysiological theme, with a few outlier terms (skin/immune/pancreatic processes) that may reflect pleiotropic roles of some proteins. Overall, the cluster most coherently represents neural excitability and cerebellar development.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":9},{"id":"GO:0002724","count":8},{"id":"GO:0097623","count":8},{"id":"GO:0019228","count":8},{"id":"GO:0097050","count":8}]},{"hash":"2228305211941740376","title":"RNA processing and ribosome biogenesis","description":"The top GO terms cluster around RNA processing and the ribosome/translation machinery: mRNA splicing, mRNA stability and catabolism, rRNA maturation, ribosome biogenesis, and translation initiation/reinitiation. Although there are a couple of unrelated terms (lens fiber differentiation, defense response), the dominant signals point to RNA processing and ribosome assembly/translation. So the name reflects the main theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0036265","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0010610","count":3}]},{"hash":"427875664885420505","title":"Gustatory signaling and sensory processing","description":"This cluster centers on sensory perception and neural signaling, with strong emphasis on taste (sweet taste detection, conditioned taste aversion), GPCR-mediated signaling, and intracellular signaling involved in sensory and behavioral responses, alongside locomotory behavior. Immune-related terms and peptidoglycan catabolism appear as outliers rather than core themes.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":8},{"id":"GO:0032781","count":8},{"id":"GO:0003380","count":8},{"id":"GO:0001582","count":7},{"id":"GO:0007196","count":7}]},{"hash":"669779760551301756","title":"T Cell Activation and Cytoskeleton Signaling","description":"These terms cluster around activation and signaling in T cells, including T cell activation via TCR-MHC interactions, NK T cell differentiation, and small GTPase\u2013mediated signaling, plus regulation of integrin activation and filopodium assembly, indicating coordinated immune signaling with cytoskeletal remodeling and adhesion. The presence of TORC1 signaling and prostaglandin response further suggests metabolic and inflammatory regulation accompanying activation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045792","count":3},{"id":"GO:0038202","count":2},{"id":"GO:0010925","count":2},{"id":"GO:0051489","count":2},{"id":"GO:0001865","count":2}]},{"hash":"262275585818479203","title":"Cell signaling and cytoskeletal regulation","description":"We see a core set of terms centered on signaling pathways (MAPK activation, JUN phosphorylation), cytoskeletal remodeling (actin cytoskeleton reorganization), and cell cycle processes (mitotic and meiotic cell cycles), plus related secretory events (vesicle docking in exocytosis) and immune response. Together these suggest a cluster of proteins involved in coordinating signaling with cytoskeletal dynamics and cell cycle control, even though a few terms pertain to more distant or species-specific processes. Confidence: Medium","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0000187","count":2},{"id":"GO:0051321","count":2},{"id":"GO:0071222","count":2}]},{"hash":"381071340806706127","title":"Lipid signaling and vesicle trafficking","description":"The cluster is enriched for GO terms tied to lipid-related processes: phosphatidylinositol dephosphorylation, ER-to-Golgi ceramide transport, and small GTPase-mediated signal transduction, all of which point to lipid signaling and vesicle trafficking. Additional terms related to growth factor signaling and apoptosis suggest broader roles in cell survival and response to stimuli, but the dominant theme appears to be lipid signaling coupled with intracellular transport. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0009555","count":2}]},{"hash":"587591997198105202","title":"Unknown","description":"Top GO terms are diverse, including neuromuscular posture control, synaptic vesicle clustering, bone morphogenesis/mineralization, interferon responses, insulin-driven glucose import, endosome-to-plasma membrane transport, and responses to biotic stimuli. There is no single cohesive function evident across the proteins, suggesting a multifunctional or mixed set rather than a clear biological module. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":2},{"id":"GO:0097091","count":2},{"id":"GO:0060349","count":2},{"id":"GO:0035456","count":2},{"id":"GO:0030282","count":2}]},{"hash":"1633798199687906924","title":"Complement-Driven Angiogenesis and ECM Remodeling","description":"This cluster is dominated by terms for immune components (complement activation, both classical and lectin pathways) and processes tied to vascular development and extracellular matrix remodeling (angiogenesis, endothelial barrier establishment, collagen catabolic processes). While some terms like lens morphogenesis and brood size are peripheral, the core pattern suggests a functional module linking immune responses with vascular/ECM dynamics. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001878","count":4},{"id":"GO:0070309","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0030574","count":3}]},{"hash":"2219453484060009515","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0097428","count":2},{"id":"GO:0034975","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0006469","count":1},{"id":"GO:0045292","count":1}]},{"hash":"2239663681985003401","title":"Vascular remodeling and coagulation","description":"The GO terms cluster around vascular remodeling, including cell-matrix adhesion, collagen fibril organization, angiogenesis, fibrinolysis, and coagulation, with inflammatory signals (acute-phase response, IL-8 production) and pregnancy-related vascular changes, suggesting a cohesive theme of vascular remodeling and coagulation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":3},{"id":"GO:0048659","count":3},{"id":"GO:0007565","count":3},{"id":"GO:0014912","count":3},{"id":"GO:0032757","count":3}]},{"hash":"981119854641884998","title":"Macrophage lipid metabolism in vascular inflammation","description":"The top GO terms cluster around lipid handling (lipoprotein transport, cholesterol storage, foam cell differentiation), macrophage/innate immunity (innate immune response, apoptotic cell clearance), and vascular context (endothelial cell proliferation, lipoprotein clearance). Together they suggest a module where macrophage lipid processing drives vascular inflammation and remodeling, akin to early atherosclerotic processes. Some ECM/development terms are present but do not override the lipid-immune vascular theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010744","count":11},{"id":"GO:0030199","count":11},{"id":"GO:0031638","count":11},{"id":"GO:0042953","count":11},{"id":"GO:0010886","count":11}]},{"hash":"327710052860079230","title":"Placental and Embryonic Development","description":"GO terms cluster around placental differentiation, embryogenesis, and organogenesis (trophoblast giant cell differentiation, EMT in endocardial cushion formation, left-right pattern formation, cartilage morphogenesis, pancreatic endocrine development), with some general gene-regulation terms reflecting developmental regulation. This supports a cohesive developmental theme centered on embryonic and placental formation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003323","count":6}]},{"hash":"1547506875491587839","title":"Rho/GTPase and kinase signaling regulation","description":"This cluster centers on modulation of signaling pathways and kinase activity, notably positive regulation of GTPase activity and protein serine/threonine kinases, along with negative regulation of Rho signaling and cytoskeletal dynamics (stress fibers). Additional terms touch on synapse assembly, cell division, and osteoblast differentiation, suggesting a broader theme of signaling pathway tuning rather than a single process. The varied yet related GO terms point to a cohesive function in regulating signaling and cytoskeletal organization.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0035024","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1397392235725053750","title":"Unknown","description":"The top GO terms are highly diverse, spanning mRNA deadenylation, host-mediated viral replication activation, immune regulation (MHC), centrosome-related localization, plant hormone signaling, root meristem growth, and pronuclear migration. There is no single coherent biological function or pathway that ties these terms together across the proteins, suggesting the cluster does not reflect a unified process. None","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000289","count":2},{"id":"GO:0044829","count":2},{"id":"GO:0045347","count":2},{"id":"GO:1904780","count":2},{"id":"GO:2000299","count":1}]},{"hash":"2234717181791914182","title":"Mitochondrial Transport and Metabolic Regulation","description":"GO terms point to mitochondrial transport processes (oligopeptide export from mitochondrion, glycerophosphodiester transport, methionine and molybdate transport) and regulation of fatty acid metabolism (beta-oxidation). There are also signals of neural development and growth (axonogenesis, stem cell proliferation) and regulatory signaling (negative regulation of protein kinase activity, endoribonuclease activity), suggesting a theme where mitochondrial metabolism interfaces with neural development and cell growth. A few terms (e.g., teichoic acid transport) are less coherent with eukaryotic mitochondria, giving moderate overall cohesion.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032000","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0072089","count":2},{"id":"GO:0060702","count":2}]},{"hash":"370190804424574826","title":"Mitotic progression and transcription regulation","description":"This cluster shows enrichment for GO terms tied to DNA-templated transcription and multiple mitotic processes (G1/S and G2/M transitions, spindle separation), indicating proteins involved in coordinating transcriptional programs with cell-cycle progression. The presence of apoptosis-related terms and proliferation signals aligns with a broader cell-cycle control theme, supporting this label as representative.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0033598","count":2},{"id":"GO:0000320","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0046626","count":2}]},{"hash":"912163442941636839","title":"Embryonic Morphogenesis Across Tissues","description":"The dominant GO terms describe morphogenesis and development across multiple embryonic tissues (gonad, placenta, hindlimb, eye, habenula, prostate-related structures). The presence of negative regulation of apoptosis and signaling pathways supports a broad developmental role rather than a single tissue-specific function. Therefore, the label captures the cluster's shared theme of embryonic tissue morphogenesis.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":10},{"id":"GO:0043066","count":9},{"id":"GO:0003148","count":9},{"id":"GO:0048048","count":9},{"id":"GO:2000288","count":9}]},{"hash":"42178832345545758","title":"Nuclear import and NPC assembly","description":"The top GO terms are dominated by nucleocytoplasmic transport: ribosomal protein import into nucleus, NLS-bearing protein import into nucleus, protein import into nucleus, and nuclear pore complex assembly, suggesting a cohesive theme around nuclear transport and NPC biogenesis. Additional terms about desumoylation regulation tie to nuclear protein homeostasis, while a few terms (intraciliary transport, meiotic cohesion) appear peripheral. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0051754","count":5},{"id":"GO:0006610","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0000060","count":5},{"id":"GO:0060188","count":5}]},{"hash":"1538442784514302415","title":"Mitotic spindle and microtubule dynamics","description":"This cluster is dominated by mitosis-related GO terms (centrosome separation, metaphase chromosome alignment, spindle elongation) and microtubule cytoskeleton polarity, with supporting cytokinesis terms, indicating a cohesive group of proteins involved in spindle assembly and microtubule regulation. A couple of terms (stress granule disassembly, ureteric bud invasion) are less central but may reflect broader signaling or morphogenesis contexts. Overall, the label captures the main functional theme.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007100","count":7},{"id":"GO:0001560","count":5},{"id":"GO:0007080","count":5},{"id":"GO:0030951","count":5},{"id":"GO:0072092","count":5}]},{"hash":"1794765036322076867","title":"Craniofacial ossification and cartilage formation","description":"The top GO terms cluster around skull and craniofacial development, including intramembranous ossification, cartilage condensation, embryonic neurocranium morphogenesis, and related signaling and ECM processes, indicating craniofacial skeletogenesis; a couple of terms (e.g., mesonephros development, xylan catabolic process) are likely peripheral noise. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001823","count":2},{"id":"GO:0034394","count":2},{"id":"GO:0030210","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0001957","count":2}]},{"hash":"1163929351544274068","title":"ER Processing & Secretory Trafficking","description":"The top GO terms cluster around translation, ER-to-Golgi transport, ER unfolded protein response, and glycosylation, which together point to proteins involved in synthesis, folding, and trafficking through the secretory pathway. Development-related terms appear but are likely secondary expression patterns. Overall, the cluster is best described by ER-associated protein processing and secretion.","confidence":"High","size":10,"edges":22,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0018279","count":2},{"id":"GO:0030968","count":2},{"id":"GO:0003007","count":2}]},{"hash":"740269689512404192","title":"Cytoskeletal dynamics and vesicle trafficking","description":"The cluster is enriched for tubulin complex assembly, vesicle docking in exocytosis, and dendrite morphogenesis, pointing to a core role in cytoskeletal remodeling and intracellular transport that underpins both cell division and neuronal morphogenesis. Some peripheral terms (e.g., regulation of arginine transport and T cell activation) may reflect broader regulatory connections rather than central cluster function, but the dominant signal centers on cytoskeletal and trafficking processes.","confidence":"Medium","size":10,"edges":29,"triangles":31,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0000278","count":7},{"id":"GO:1900242","count":6},{"id":"GO:0007021","count":6},{"id":"GO:0006904","count":6}]},{"hash":"914735401105128305","title":"Ubiquitin-mediated ERAD and mitophagy","description":"The top GO terms point strongly to ubiquitin-related processes (deubiquitination, autoubiquitination, sumoylation), ER-associated degradation (ERAD), and mitophagy, with additional links to mitochondrial dynamics (mitochondrial fusion) and related stress responses. This pattern suggests a cluster centered on protein quality control via ubiquitin signaling, spanning ER and mitochondrial contexts, rather than disparate functions. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":7},{"id":"GO:0030433","count":6},{"id":"GO:1902236","count":5},{"id":"GO:0045648","count":5},{"id":"GO:0033132","count":5}]},{"hash":"860299450731984504","title":"Spliceosome Assembly and Translation Initiation Regulation","description":"The GO terms center on mRNA splicing via the spliceosome (splicing, splice site recognition, alternative splicing, processome assembly) and on translation initiation (regulation of translational initiation, eIF4F complex assembly, preinitiation complex formation). The combination of positive/negative regulation of splicing with components of the initiation machinery suggests a module coordinating RNA processing with translation initiation, consistent with spliceosome-related factors and preinitiation complex assembly roles.","confidence":"High","size":10,"edges":20,"triangles":8,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006446","count":5},{"id":"GO:0045292","count":4},{"id":"GO:0034462","count":4},{"id":"GO:0006376","count":4},{"id":"GO:0097010","count":4}]},{"hash":"1151902516111509315","title":"Regulated cell signaling and adhesion remodeling","description":"The top terms point to broad regulatory signaling (peptidyl-tyrosine phosphorylation, IGF receptor signaling) coupled with changes in cell adhesion and extracellular matrix interactions (cell-matrix adhesion, ectodomain proteolysis), and further linked to tissue morphogenesis/migration (epithelial integrity, smooth muscle migration, oligodendrocyte differentiation). Together these suggest a theme of signaling-driven modulation of adhesion and remodeling across multiple tissues, rather than a single, specific function.","confidence":"Medium","size":10,"edges":19,"triangles":15,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0035160","count":2},{"id":"GO:0033690","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0051044","count":2},{"id":"GO:0048714","count":2}]},{"hash":"261280327014490638","title":"Unknown","description":"The top GO terms span plant pigment biosynthesis, mammalian xenobiotic processing, bacterial cell wall and glycan biosynthesis, antibiotic production, and even neuronal axon protein localization, with no clear shared function. This mix suggests annotation noise or a heterogeneous cluster rather than a single coherent biological theme, so a concise, unambiguous label isn\u2019t derivable.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":7},{"id":"GO:0033330","count":6},{"id":"GO:0006711","count":6},{"id":"GO:0006488","count":6},{"id":"GO:0009252","count":6}]},{"hash":"1348835176966730785","title":"Neuronal signaling and taste perception","description":"These proteins are enriched in neural signaling and taste-related processes: conditioned taste aversion and detection of sweet taste point to gustatory pathways; GABA signaling and excitatory postsynaptic potential indicate synaptic transmission and neuronal excitability; sodium and potassium ion transport and receptor internalization reflect ion gradients and receptor turnover essential for signaling. Together, the cluster represents neuronal signaling tied to taste perception and sensory-driven locomotion.","confidence":"High","size":10,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":9},{"id":"GO:0001661","count":9},{"id":"GO:0007214","count":9},{"id":"GO:0035725","count":8},{"id":"GO:0071805","count":8}]},{"hash":"970725110871074233","title":"Amino acid biosynthesis and related metabolism","description":"This cluster is enriched for several amino acid\u2013related processes (valine biosynthesis, methionine cycle) and connected metabolic pathways (one-carbon metabolism, shikimate pathway), suggesting a cohesive theme around amino acid production and related metabolism, despite some noisy or obsolete terms.","confidence":"Low","size":10,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006730","count":2},{"id":"GO:0009099","count":1},{"id":"GO:0035635","count":1},{"id":"GO:0019632","count":1}]},{"hash":"1460926395036750327","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":25,"triangles":28,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0032781","count":4},{"id":"GO:0034975","count":3},{"id":"GO:0006458","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0045454","count":3}]},{"hash":"213491187064369744","title":"Innate Immune and ER Stress Response","description":"This cluster centers on innate immune signaling and cellular stress responses. Terms like innate immune response, unfolded protein response, and ER-associated ubiquitin-dependent protein catabolic process point to immune coordination with endoplasmic reticulum stress and protein quality control. The other terms (lead ion response, mitochondria distribution, steroid receptor complex assembly) hint at broader signaling roles but do not override the core theme. Therefore, a label like Innate Immune and ER Stress Response best captures the dominant functions.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0048312","count":4},{"id":"GO:0010288","count":4},{"id":"GO:0006463","count":3}]},{"hash":"208392432573867092","title":"Platelet Activation and Inflammatory Pain Signaling","description":"The cluster features strong signals for platelet activation, integrin activation, ATP- and calcium-mediated signaling, and IL-1\u03b2 production, which together point to platelet-driven inflammatory signaling. The included pain-related terms (regulation of sensory perception of pain and neuronal activity) suggest some cross-talk with neural pain pathways, though the core theme centers on platelet/inflammatory signaling. Some development-related terms are less central to the main function of the cluster.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030168","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0051930","count":2},{"id":"GO:0071318","count":2},{"id":"GO:0033622","count":2}]},{"hash":"2299737030477061502","title":"Innate immune signaling and actin remodeling","description":"This cluster centers on innate immune responses and antiviral defense, with additional GO terms pointing to receptor tyrosine kinase signaling and actin cytoskeleton dynamics (actin filament network formation and lamellipodium regulation). The combination suggests a theme where immune signaling is coupled with cytoskeletal remodeling and potentially cell migration. Some terms are obsolete or developmental, but the core appears to be immune signaling linked to cytoskeletal changes.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0051770","count":2},{"id":"GO:1902499","count":2}]},{"hash":"6247649809154550","title":"Retina Development and Photoreceptor Phagocytosis","description":"The cluster is enriched for retina and eye development terms (retina development in camera-type eye, photoreceptor cell maintenance) and for phagocytosis-related terms (phagocytosis, recognition, and positive regulation), suggesting a cohesive role in retinal development and photoreceptor maintenance with debris clearance. Hedgehog-related signaling terms are present but secondary to the eye/retina-focused processes, with some cell cycle/apoptosis terms loosely connected to developmental regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0060831","count":1},{"id":"GO:0045494","count":1},{"id":"GO:1901621","count":1}]},{"hash":"1901387764499206336","title":"Vacuolar amino acid and ion transporters","description":"The cluster is dominated by GO terms for transmembrane transport of amino acids (asparagine, glutamate, glutamine, proline, serine) and by export/import across the vacuolar membrane (lysine, histidine), plus several ion transport terms. This pattern strongly points to a cohesive set of vacuolar transporter proteins handling amino acids and ions. The note about 4 proteins re-added by Recipe and lack of edges do not diminish the clear functional theme. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006867","count":2},{"id":"GO:1901481","count":2},{"id":"GO:2000487","count":2},{"id":"GO:0089707","count":2},{"id":"GO:0089708","count":2}]},{"hash":"2047509194961430061","title":"Developmental Transcriptional Regulators","description":"The cluster\u2019s top GO terms emphasize transcriptional control (RNA polymerase II activity, p53-mediated DNA damage signaling) coupled with developmental processes (lung morphogenesis, hypothalamic migration, circulatory system development) and immune regulation (T cell differentiation, IL-2 production). This points to proteins that primarily regulate gene expression in developmental and immune contexts, with one outlier term (vocal learning) likely reflecting annotation noise rather than a core function. Overall, a cohesive theme of transcriptional regulation across development and immune signaling emerges.","confidence":"Medium","size":10,"edges":39,"triangles":83,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0090419","count":10},{"id":"GO:0042297","count":10},{"id":"GO:0033085","count":10},{"id":"GO:0002669","count":10},{"id":"GO:0060441","count":10}]},{"hash":"760398723055556465","title":"Transcription and chromatin regulation in development","description":"This cluster is dominated by GO terms for DNA-templated transcription, mRNA processing, and chromatin-related processes (histone methylation and deubiquitination), pointing to gene expression regulation at the epigenetic level. Developmental terms (forebrain and skeletal system development) suggest a shared role in developmental gene regulation. A defense response term is present but appears less central to the core theme. Overall, the data support a cohesive theme of transcriptional control and chromatin modification during development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0006397","count":2}]},{"hash":"2132162506700182888","title":"Cardiac electrophysiology and mitochondrial dynamics","description":"This cluster centers on heart function: regulation of heart rate by cardiac conduction, heart contraction, atrial cardiac muscle cell action potential, and voltage-gated calcium channel activity, along with potassium ion import. It also includes mitochondrial dynamics (fission/fusion) and proteasomal protein turnover, suggesting a cardiomyocyte program that couples electrical activity with energy management and protein regulation. An epithelial maturation term appears as an outlier, but the cardiac signal is dominant. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090141","count":2},{"id":"GO:0010637","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0086091","count":1},{"id":"GO:0060047","count":1}]},{"hash":"610982923628122332","title":"Chromatin regulation in development","description":"The cluster\u2019s top GO terms emphasize chromatin-level control\u2014negative regulation of transcription by RNA Pol II, rDNA heterochromatin formation, and histone deacetylation\u2014along with telomere-related regulation (shelterin assembly, RNA localization to telomeres). Coupled with development-related terms (brain development, cardiac atrium morphogenesis, male gonad development, single fertilization), this points to a group of chromatin/epigenetic regulators that participate in developmental processes. Some terms like viral processes are likely secondary associations rather than core functions. ","confidence":"Medium","size":10,"edges":12,"triangles":2,"max_degree":6,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0000183","count":7},{"id":"GO:0008584","count":6},{"id":"GO:0007338","count":5},{"id":"GO:0003209","count":5}]},{"hash":"1424873911356525759","title":"Motor Neuron Development and Axon Guidance","description":"This cluster shows a cohesive theme around spinal cord motor neuron differentiation, axon guidance, and interneuron specification (e.g., motor neuron axon guidance, spinal cord motor neuron cell fate specification, medial motor column differentiation, and ventral spinal interneuron specification). A few terms related to organ morphogenesis (kidney, uterus, thyroid) appear but are likely secondary or pleiotropic. Overall, the dominant signal is motor neuron development and guidance.","confidence":"High","size":10,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":3},{"id":"GO:0008045","count":2},{"id":"GO:0021520","count":2},{"id":"GO:0021526","count":2},{"id":"GO:0072283","count":2}]},{"hash":"387653322479355950","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":2},{"id":"GO:0034628","count":1},{"id":"GO:0015937","count":1},{"id":"GO:0019350","count":1},{"id":"GO:0097171","count":1}]},{"hash":"490425270997158706","title":"Neuronal development and synaptic vesicle regulation","description":"The proteins cluster around neural development and synaptic function, as shown by enrichment for regulation of synaptic vesicle exocytosis and endocytosis, dendrite morphogenesis, and retina layer formation. Some terms reflect broader developmental or stress-related contexts (hypoxia, oxidative processes, protein methylation), but the strongest signal ties to neuronal differentiation and synaptic regulation. Confidence: Medium","confidence":"","size":10,"edges":13,"triangles":2,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":5},{"id":"GO:0006479","count":5},{"id":"GO:1900242","count":5},{"id":"GO:2001015","count":5},{"id":"GO:2000300","count":5}]},{"hash":"921806922410092073","title":"Vertebrate Development and Angiogenesis","description":"Based on multiple development-related GO terms (multicellular organism development, forebrain development, skeletal system development, glomerular basement membrane development) and the explicit regulation of angiogenesis, the proteins in this cluster appear to participate in vertebrate organogenesis and blood vessel formation. A few terms (cadmium response, MAPK) are ancillary noise but do not override the central developmental/angiogenic theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000187","count":3},{"id":"GO:0045987","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1320325098303596533","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0072089","count":2},{"id":"GO:0007014","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0061158","count":2},{"id":"GO:0018032","count":2}]},{"hash":"1544240071099918930","title":"Neuronal Signaling and Axon Guidance","description":"This cluster centers on neural development and signaling: axon extension and branching morphogenesis of a nerve, dopamine receptor signaling, and receptor tyrosine kinase pathways indicate neurite outgrowth and synaptic signaling. The presence of TLR2 and NOD-like receptor signaling terms suggests some immune-related signaling components, which can intersect with neural signaling. Overall, the terms converge on neural development and neurotransmission.","confidence":"Medium","size":10,"edges":11,"triangles":2,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048846","count":8},{"id":"GO:0051770","count":5},{"id":"GO:1902499","count":5},{"id":"GO:0060161","count":5},{"id":"GO:0007169","count":5}]},{"hash":"518850729155746087","title":"Unknown","description":"The top terms span ubiquitination, plant growth responses (phototropism, gravitropism), immune cell differentiation (pro-T cells, dendritic cells), kidney sodium absorption, and muscle development, indicating no single shared function across the proteins. Therefore a meaningful, cohesive label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990390","count":4},{"id":"GO:0009638","count":4},{"id":"GO:0032764","count":4},{"id":"GO:0009958","count":4},{"id":"GO:2000176","count":4}]},{"hash":"1518469191946633705","title":"LPS and dsRNA Innate Immunity","description":"This cluster centers on innate immune signaling, highlighted by cellular response to lipopolysaccharide, LPS-mediated signaling, response to exogenous dsRNA, innate immune response, and interferon-beta production. Additional terms like positive regulation of GTPase activity and platelet activation fit immune signaling; dopamine-related and corpus callosum development terms are less central and may reflect broader annotation contexts.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0010572","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0045359","count":4}]},{"hash":"84770085759302660","title":"Mitochondrial Dynamics and Metabolic Regulation","description":"The top GO terms point to mitochondrial processes (membrane localization involved in fission, membrane fission, apoptotic mitochondrial changes) together with energy/metabolic functions (adaptive thermogenesis, insulin secretion regulation, pyridoxal phosphate transport) and liver-related metabolism. Despite some obsolete terms, the common theme is mitochondria-centric control of cellular energy and metabolism.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090152","count":6},{"id":"GO:0007565","count":6},{"id":"GO:0000002","count":6},{"id":"GO:1990845","count":6},{"id":"GO:0097274","count":6}]},{"hash":"11730179502006296","title":"DNA replication and mitotic chromosome maintenance","description":"The cluster shows strong enrichment for DNA replication, homologous recombination repair of double-strand breaks, meiotic DSB formation, and spindle-kinetochore attachment, all tied to cell cycle progression and genome integrity, with apoptosis regulation as a related pathway. Some developmental terms are present but likely reflect pleiotropy rather than a distinct functional theme. ","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2001241","count":8},{"id":"GO:0050774","count":8},{"id":"GO:0042220","count":8},{"id":"GO:0097552","count":8},{"id":"GO:0010780","count":8}]},{"hash":"1426033142630086537","title":"Male germ cell development and redox homeostasis","description":"The cluster shows strong representation of GO terms tied to male gonad development and spermatogenesis, plus processes related to oxidative stress response and mitochondrial function (e.g., removal of superoxide radicals, cytochrome complex assembly). This suggests a theme centered on sperm development with supportive redox and energy metabolism roles.","confidence":"Medium","size":9,"edges":28,"triangles":44,"max_degree":8,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0008584","count":7},{"id":"GO:0034101","count":7},{"id":"GO:0032872","count":7},{"id":"GO:0045454","count":7},{"id":"GO:0042158","count":7}]},{"hash":"1760440223614789283","title":"Reproductive Steroid and Prostaglandin Metabolism","description":"The top GO terms cluster around prostaglandin biosynthesis, sex differentiation, and female genitalia development, plus androgen and cholesterol metabolism and vitamin D\u2013related processes, all related to maternal parturition signals. This suggests a function in lipid-derived signaling and steroid hormone pathways governing reproductive development and parturition timing.","confidence":"High","size":9,"edges":24,"triangles":27,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":9},{"id":"GO:0060137","count":6},{"id":"GO:0010164","count":6},{"id":"GO:0030540","count":6},{"id":"GO:0042369","count":6}]},{"hash":"891975917128626216","title":"Taste and Smell Sensing, Learning, Vasopressin Signaling","description":"The cluster\u2019s top GO terms center on sensory detection (taste and olfactory cues), learning and memory processes (long-term memory, conditioned taste aversion, olfactory learning), and signaling pathways linked to vasopressin and cAMP cascades (cellular response to forskolin, intracellular signal transduction). While there are also renal/osmoregulatory terms, the strongest pattern ties sensory perception to memory-related processes and vasopressin-associated signaling, suggesting a unified theme of taste/smell sensing connected to learning and hormonal signaling regulating physiology.","confidence":"High","size":9,"edges":6,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0070483","count":6},{"id":"GO:0001582","count":6},{"id":"GO:0003091","count":6},{"id":"GO:0035811","count":6},{"id":"GO:1904322","count":6}]},{"hash":"1998812244954341569","title":"Mitochondrial Metabolite Transport","description":"The proteins cluster around mitochondrial metabolite and energy transport, highlighted by GO terms for iron import into mitochondrion, glycine import, L-ornithine transport, alpha-ketoglutarate transport, the malate-aspartate shuttle, and mitochondrial ATP transport. This suggests a cohesive role in mitochondrial metabolite exchange and energy management, with a few non-core terms (e.g., insulin response, pregnancy) that may reflect broader metabolic context or annotation noise.","confidence":"High","size":9,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048250","count":5},{"id":"GO:0036233","count":5},{"id":"GO:0000066","count":5},{"id":"GO:0015742","count":5},{"id":"GO:0043490","count":5}]},{"hash":"1461372143515046736","title":"Dopaminergic Signaling and Sensory Perception","description":"This cluster is dominated by neural-relatedGO terms: dopaminergic synaptic transmission, visual perception, and visual learning, plus behavioral responses to cocaine, pointing to dopaminergic signaling and sensory/behavioral processing. The presence of ERK cascade regulation and prostaglandin response supports signaling pathway activity, while other terms like heart development and DNA repair are less central and don\u2019t override the dominant neural/sensory theme. Overall, the proteins likely participate in neural signaling and sensory-driven behaviors, particularly involving dopamine pathways.","confidence":"Medium","size":9,"edges":15,"triangles":16,"max_degree":6,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071380","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0007507","count":8}]},{"hash":"1861215355860498937","title":"Cell Cycle and Genome Maintenance","description":"The top GO terms cluster around DNA replication, transcription, ribosome biogenesis, and cell division, with supporting DNA repair activity. These represent core housekeeping processes for cell growth, genome duplication, and maintenance, suggesting a cohesive module focused on proliferation and genome integrity; the additional stress and developmental terms appear as peripheral or context-specific annotations. Overall, the group aligns well with cell cycle progression and genome maintenance functions.","confidence":"High","size":9,"edges":17,"triangles":10,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006281","count":2}]},{"hash":"2277742600429997448","title":"Iridophore differentiation and redox regulation","description":"The cluster prominently features iridophore differentiation (pigment cell development) and redox homeostasis, along with protein transport and geranylgeranylation (membrane-targeting processes). This suggests a theme combining pigment cell development in fish with redox balance and membrane-associated protein processing, hence the label. ","confidence":"Medium","size":9,"edges":14,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0050935","count":2},{"id":"GO:0015031","count":2},{"id":"GO:2000541","count":2}]},{"hash":"1050546342551031449","title":"Neural development and neuronal processes","description":"The top GO terms center on nervous system development (brain and neural development) and neuronal cell biology (regulation of synaptic vesicle endocytosis, oligodendrocyte differentiation, tubulin complex assembly), with some connection to cell cycle processes. While some terms touch on kidney and spermatid development, the dominant signal points to neural development and neuronal cellular activities, suggesting a cluster of proteins involved in nervous system formation and function.","confidence":"Medium","size":9,"edges":10,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0000278","count":3},{"id":"GO:1903206","count":3}]},{"hash":"185079029532645956","title":"Proteostasis and mitochondrial quality control under stress","description":"The cluster centers on stress-responsive proteostasis processes: mitophagy, aggresome assembly, and regulation of mitochondrial fusion indicate control of mitochondrial quality. Post-translational modifications (protein ubiquitination, sumoylation) and deglycosylation reflect protein quality control, while ER stress\u2013related apoptosis modulation and TNF signaling tie these responses to broader cellular stress pathways. The erythrocyte differentiation term appears less connected and may be peripheral. Overall, the set suggests a cohesive theme of proteostasis and mitochondrial maintenance during stress.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":9},{"id":"GO:0045648","count":9},{"id":"GO:0033132","count":9},{"id":"GO:0000423","count":9},{"id":"GO:0051865","count":9}]},{"hash":"2171773572781015012","title":"Dopaminergic GPCR Signaling and Neuroendocrine Regulation","description":"This cluster centers on dopaminergic synaptic transmission and GPCR signaling that couples to cGMP, with additional links to neuroendocrine control of blood pressure (renin), metabolic heat generation, and vascular/immune aspects. The combination of dopaminergic signaling, GPCR-cGMP pathways, and neuroendocrine outputs suggests a cohesive module integrating neural signaling with hormonal and vascular regulation, rather than unrelated processes.","confidence":"Medium","size":9,"edges":12,"triangles":10,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":3},{"id":"GO:0042755","count":3},{"id":"GO:0001963","count":3},{"id":"GO:0007199","count":3},{"id":"GO:1900134","count":3}]},{"hash":"918010977569233467","title":"Unknown","description":"The GO terms span lipid metabolism (lipoprotein lipase activity, chylomicron remnant clearance, fibrinolysis), vascular/lymphatic and kidney tubule morphogenesis, and nervous/muscle movement (locomotory behavior, neuromuscular posture) as well as apoptosis regulation. There is no clear, single biological process tying all terms together, suggesting the cluster contains multifunctional or unrelated proteins rather than a cohesive functional module.","confidence":"","size":9,"edges":11,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051006","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0036303","count":3},{"id":"GO:0072287","count":3},{"id":"GO:0072237","count":3}]},{"hash":"1997293445497775126","title":"Wnt signaling and differentiation regulators","description":"This cluster centers on Wnt signaling (GO:0016055) with associated functions in mesenchymal stem cell differentiation, and regulation of endothelial barrier establishment, plus related signaling modulators like Rac pathway regulation and synapse assembly. Together these suggest a module involved in developmental signaling and cell fate/differentiation processes across tissues. Some terms (sensory perception of sound, meiotic division) are likely annotation noise or broadly shared terms not specific to a single pathway here.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:2000741","count":2},{"id":"GO:0016055","count":2},{"id":"GO:1903142","count":2},{"id":"GO:0035021","count":2}]},{"hash":"92591638738800624","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for ribosome biogenesis, small subunit assembly, and rRNA maturation/export, plus translation, indicating proteins involved in assembling functional ribosomes and carrying out protein synthesis. The presence of post-transcriptional regulation and cell-cycle terms likely reflects coordination between ribosome production, mRNA turnover, and growth. Overall, the theme is ribosome biogenesis and translation.","confidence":"High","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":3},{"id":"GO:0031564","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0006407","count":2}]},{"hash":"1990052216556914482","title":"One-carbon metabolism and nucleotide biosynthesis","description":"The most represented terms cluster around folate-mediated one-carbon metabolism\u2014L-serine catabolic process, tetrahydrofolate interconversion, dTMP and purine nucleobase biosynthesis, and related glycine biosynthesis\u2014indicating a cohesive theme of one-carbon units fueling nucleotide synthesis, with a few ancillary terms likely incidental.","confidence":"High","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006565","count":3},{"id":"GO:0009113","count":3},{"id":"GO:0035999","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0055114","count":2}]},{"hash":"2278429354190006140","title":"Steroid biosynthesis and lipid metabolism","description":"Top GO terms indicate strong representation of steroid biosynthetic and androgen/metabolic processes (testosterone biosynthetic, androgen metabolic, steroid catabolic) along with lipid-related biosynthesis/catabolism (methyl-branched fatty acid biosynthetic, 3-keto-sphinganine metabolic). This suggests the cluster comprises proteins involved in steroid and lipid metabolic pathways. Some outlier terms (lung development, obsolete oxidation-reduction) appear but are less representative of the core theme.","confidence":"Medium","size":9,"edges":6,"triangles":0,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:1902321","count":8},{"id":"GO:0008209","count":8},{"id":"GO:0006666","count":8},{"id":"GO:0006706","count":8},{"id":"GO:0042376","count":8}]},{"hash":"922630149914644128","title":"Muscle- and vascular-development signaling","description":"The top GO terms cluster around signaling pathways that regulate muscle and heart development (e.g., positive regulation of calcineurin-NFAT signaling, regulation of cardiac muscle cell differentiation, detection of muscle stretch) and vascular formation (coronary vasculature development). There are also related processes like exocytosis and microtubule polarity that fit into general cellular signaling and morphogenesis. Although some terms are broader or peripheral (e.g., uterine epithelium development, hepatocyte proliferation regulation), the strongest recurring theme is signaling linked to muscle/mechanogenesis and vascular development, centered on NFAT/Cn signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070886","count":4},{"id":"GO:2000346","count":3},{"id":"GO:0046013","count":3},{"id":"GO:2000691","count":3},{"id":"GO:0035995","count":3}]},{"hash":"1174952317558737931","title":"Immune Activation and Leukocyte Migration","description":"This cluster is dominated by GO terms tied to immune responses and leukocyte movement, including positive regulation of T cell chemotaxis, leukocyte migration in inflammatory response, and cellular responses to IL-1 and TNF. The presence of ubiquitin-dependent protein catabolic process suggests regulation of signaling and protein turnover linked to immune signaling pathways. While a few terms touch on development or cell cycle processes, the core theme centers on immune activation and inflammatory cell trafficking.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0010820","count":2},{"id":"GO:0002523","count":2},{"id":"GO:1901509","count":2},{"id":"GO:0071347","count":2}]},{"hash":"1977363205976230665","title":"Acetylation of amino and polyamine substrates","description":"The top GO terms cluster around acetylation events (N-terminal methionine/serine acetylation and putrescine/spermine acetylation) and related metabolic pathways (glucosamine/N-acetylglucosamine metabolism, ectoine biosynthesis, and mycothiol biosynthesis). This points to a cohesive theme of acetylation-modified substrates and related nitrogenous compound metabolism common in bacteria/actinobacteria, despite an outlier term (angiogenesis) that may be misannotation. ","confidence":"Medium","size":9,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":7},{"id":"GO:0019491","count":7},{"id":"GO:0017196","count":7},{"id":"GO:0032920","count":7},{"id":"GO:0006044","count":7}]},{"hash":"2212705101838021353","title":"Fungal actin dynamics and inheritance","description":"Based on the top GO terms, the cluster is dominated by actin cytoskeleton processes (Arp2/3-mediated nucleation, actin cortical patch assembly, sarcomere organization). The presence of ascospore wall assembly suggests a fungal context, and mitochondrion/vacuole inheritance points to actin-driven organelle partitioning during cell division. Together these terms indicate a theme of actin-mediated cytoskeletal remodeling coupled with organelle inheritance in fungi.","confidence":"High","size":9,"edges":29,"triangles":56,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0034314","count":7},{"id":"GO:0030476","count":7},{"id":"GO:0051592","count":7},{"id":"GO:0000011","count":7},{"id":"GO:0045214","count":7}]},{"hash":"2110545961184869408","title":"Regulated Vesicle Trafficking and Exocytosis","description":"The enriched GO terms point to control of endocytosis and vesicle fusion, including receptor-mediated endocytosis, ubiquitin-dependent endocytosis, and synaptic vesicle exocytosis, as well as regulation of dopamine secretion. This pattern suggests a core function in vesicle trafficking and membrane remodeling, with some immune and developmental terms reflecting broader roles of vesicle dynamics in signaling and cell fusion. Overall, a cohesive theme of regulated vesicle trafficking and secretion best fits the cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048260","count":4},{"id":"GO:0031340","count":4},{"id":"GO:0002669","count":4},{"id":"GO:2000300","count":4},{"id":"GO:0002316","count":4}]},{"hash":"919102460767633361","title":"Neural development and axon signaling","description":"This cluster centers on neural development terms (central nervous system development, neurogenesis, nervous system development, nerve impulse transmission) and axon-associated processes (paranode localization) with supporting signaling pathways (receptor tyrosine kinase and BMP signaling). Angiogenesis may reflect neurovascular development, but the dominant theme is neural development and axon signaling.","confidence":"High","size":9,"edges":30,"triangles":51,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0050925","count":4},{"id":"GO:0007169","count":4},{"id":"GO:0022008","count":4}]},{"hash":"274936050866127872","title":"Cytoskeletal remodeling and developmental signaling","description":"This cluster centers on actin cytoskeleton dynamics (stress fiber and filopodium assembly, Rac signaling) and a suite of developmental signaling pathways (Roundabout, Smoothened/Hedgehog, T cell receptor) with associated nervous system and kidney development terms, plus mitotic spindle assembly indicating broader cytoskeletal involvement. The common theme appears to be coordinated cytoskeletal remodeling coupled with developmental signaling cues.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051496","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0007399","count":4}]},{"hash":"727726390858974715","title":"Embryonic organogenesis","description":"This cluster centers on developmental morphogenesis across multiple tissues: kidney nephron and ureteric bud morphogenesis, lacrimal and otic placode development, peripheral nervous system and neural crest formation, skeletal muscle differentiation, and pituitary development. The recurring theme is embryonic organ formation and tissue differentiation, supported by DNA-templated transcription as a common regulatory mechanism. Confidence: High","confidence":"","size":9,"edges":28,"triangles":44,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0072289","count":5},{"id":"GO:0032808","count":5},{"id":"GO:0007422","count":5},{"id":"GO:0035914","count":5},{"id":"GO:0090190","count":5}]},{"hash":"1723556979765021742","title":"Neuronal development and synaptic vesicle regulation","description":"This cluster centers on neural development and neuronal communication: axonogenesis, neural crest formation, and visual perception point to developing neurons (including retina), while regulation of synaptic vesicle exocytosis/endocytosis indicates control of synaptic transmission. Additional terms like transcription regulation and protein methylation reflect gene expression control during neural development, with hypoxia response suggesting stress-related modulation common in neural tissues.","confidence":"High","size":9,"edges":21,"triangles":23,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045944","count":8},{"id":"GO:0006469","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0007409","count":8},{"id":"GO:0014029","count":7}]},{"hash":"392514726538490487","title":"NF-kappaB-driven innate immune response","description":"Top GO terms cluster around innate immune activation and NF-kappaB signaling (innate immune response, positive regulation of canonical NF-kappaB signaling, response to lipopolysaccharide), with associated inflammatory contexts (wound healing, hypoxia response). A few terms are peripheral (synapse assembly, muscle differentiation), but the dominant theme ties NF-kappaB-mediated inflammation together.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0042060","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0051965","count":3}]},{"hash":"1542674053523671019","title":"Spliceosome and RNA-processing machinery","description":"Top GO terms indicate strong involvement in nuclear RNA processing and splicing, with multiple terms for spliceosome assembly, mRNA splicing, snRNP biogenesis, and RNA maturation (tRNA and rRNA processing) as well as transcription termination. While a few terms touch on chromatin or cell-cycle regulation, the dominant signal is RNA processing and spliceosome-related functions, justifying a label focused on splicing and RNA maturation.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0008033","count":8},{"id":"GO:0000245","count":8},{"id":"GO:1990141","count":8},{"id":"GO:0000290","count":8}]},{"hash":"359501226906244578","title":"Triglyceride Catabolism and Lipid Remodeling","description":"The cluster is dominated by GO terms for triglyceride catabolic processes, triglyceride mobilization, and remodeling of lipid molecules (phosphatidylcholine and phosphatidylethanolamine catabolic processes). This points to a cohesive theme of triglyceride turnover and phospholipid remodeling, with a few peripheral signals related to regulation of signaling pathways or immune processes.","confidence":"High","size":9,"edges":17,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0036153","count":3},{"id":"GO:2000480","count":3},{"id":"GO:0046338","count":3},{"id":"GO:0010898","count":3},{"id":"GO:0034638","count":3}]},{"hash":"1881987550645398259","title":"Neuronal actin remodeling and synapse assembly","description":"This cluster is enriched for actin cytoskeleton dynamics (sarcomere organization, actin filament fragmentation, regulation of actin cytoskeleton) and neuron-specific structural processes (axonal fasciculation, myelination, otolith morphogenesis, positive regulation of synapse assembly). Signaling terms like Rho and PI3K-related pathways further support actin remodeling in neuronal development and connectivity. Confidence: High","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:2000249","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0042552","count":2}]},{"hash":"965632623605154269","title":"Developmental and Immune Signaling Modulators","description":"The cluster centers on regulation of signaling pathways (Wnt, integrin, TGF-\u03b2, LPS signaling) and processes linked to development and immune cell differentiation (endothelial barrier establishment, adipose development, B and NK T cell differentiation). Peroxisome protein import docking and brood-size regulation suggest broader regulatory roles but still align with signaling-mediated tissue development and immune function. ","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060378","count":4},{"id":"GO:0090557","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0007229","count":4},{"id":"GO:0016560","count":4}]},{"hash":"518019998553522520","title":"RNA transcription and ribosome biogenesis","description":"This cluster's GO terms cluster around transcription by RNA polymerases I, II, and III, plus RNA-templated transcription and various aspects of ribosome biogenesis (including Pol III\u2013driven tRNA transcription and elongation/termination). Together these indicate a cohesive role in transcriptional machinery and ribosome production. A few terms about pancreatic cell development seem incidental outliers. ","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006360","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0006386","count":1},{"id":"GO:0006385","count":1}]},{"hash":"2222238168514355490","title":"Nuclear transport and ribosome assembly","description":"The top terms cluster around nucleus-centered processes: import/export of ribosomal subunits and mRNA, nuclear pore complex assembly, and import of NLS-bearing proteins/hNRNPs, with desumoylation regulation occurring in the nucleus. This points to a coherent function group focused on nuclear transport and ribosome maturation. ","confidence":"High","size":9,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060188","count":5},{"id":"GO:0051292","count":5},{"id":"GO:0006610","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0000056","count":5}]},{"hash":"1605794606036791208","title":"Plant Primary Metabolism with Photorespiration","description":"The top GO terms center on core plant metabolic processes: photorespiration, glycolate and mandelate catabolism, L-glutamate biosynthesis, isoprenoid biosynthesis, purine metabolism, and oxidative photosynthetic carbon pathway. This mix suggests a cluster of proteins involved in general plant primary metabolism and carbon/nitrogen flux. The retina development and immune-related terms are outliers, likely annotation spillover, and do not define the cluster's main function.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0006144","count":1},{"id":"GO:0008299","count":1},{"id":"GO:0009853","count":1},{"id":"GO:0097054","count":1}]},{"hash":"1409898507482160513","title":"Unknown","description":"The terms span innate immune signaling, transcription regulation, cell division, muscle development, apoptosis regulation, endocytosis and clathrin trafficking, and amyloid-beta formation. This broad and diverse set lacks a single cohesive functional theme, making it inappropriate to assign a specific, meaningful label.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001878","count":2},{"id":"GO:0007052","count":1},{"id":"GO:0035660","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0007527","count":1}]},{"hash":"749405247958915967","title":"Spliceosome-assembly and translation initiation factors","description":"The cluster\u2019s top GO terms center on RNA splicing via the spliceosome (including splice-site recognition and small-subunit processome assembly) and translation initiation (formation of the preinitiation complex and eIF4F complex assembly). This points to a cohesive RNA-processing module linking splicing regulation with initiation of translation, suggesting these proteins participate in RNA maturation and subsequent translation readiness.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0045292","count":3},{"id":"GO:0034462","count":3},{"id":"GO:0006376","count":3}]},{"hash":"506942256584393478","title":"Muscle development and calcium signaling","description":"This cluster centers on muscle biology and calcium-dependent signaling, with terms like cardiac muscle contraction and myoblast fusion, plus regulatory processes such as cellular response to calcium, vesicle exocytosis, and phosphatidylinositol signaling that together link signaling to muscle differentiation and function.","confidence":"High","size":9,"edges":15,"triangles":10,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":5},{"id":"GO:2000300","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0030948","count":3}]},{"hash":"1173165639341162381","title":"TGF-\u03b2/BMP signaling in cartilage and bone","description":"This cluster centers on chondrocyte differentiation and osteoblast differentiation, with multiple terms showing regulation of BMP and TGF-\u03b2 signaling (including negative regulation of BMP signaling and TGF-\u03b2 receptor signaling) and SMAD-related processes. Additional terms about cellular response to TGF-\u03b2, stress fiber assembly, and vascular development in the labyrinthine layer support a common theme of coordinated skeletal development and tissue remodeling driven by TGF-\u03b2/BMP pathways. Therefore, the label reflects a module of proteins modulating cartilage and bone formation through TGF-\u03b2/BMP signaling and related SMAD regulation.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0002062","count":3},{"id":"GO:0030514","count":2},{"id":"GO:0030512","count":2},{"id":"GO:0010991","count":2},{"id":"GO:0071560","count":2}]},{"hash":"2269619714394134346","title":"Immune signaling and ER trafficking","description":"The top GO terms cluster around T cell cytokine production, T cell apoptotic processes, and innate immune signaling, indicating an immune activation theme. Coupled with protein transport and ER lumen retention, the data also point to cellular protein handling in the secretory pathway. A few terms related to insect development and glycan biosynthesis appear as noise, but the dominant signal is immune signaling intertwined with ER-associated protein trafficking.","confidence":"Medium","size":9,"edges":10,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0014912","count":2},{"id":"GO:0002369","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0070231","count":2},{"id":"GO:0006621","count":2}]},{"hash":"927728087677953016","title":"N-linked glycosylation and ER-Golgi trafficking","description":"This cluster is dominated by GO terms tied to glycosylation and the secretory pathway, including protein N-linked glycosylation, N-glycan processing, glycosylceramide metabolism, and ER-to-Golgi vesicle transport, suggesting a shared role in glycan modification and trafficking between the ER and Golgi. Some terms about pollen germination and olfactory development may be cross-annotation noise, but the core signal points to glycosylation and secretory processing.","confidence":"Medium","size":9,"edges":16,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006487","count":1},{"id":"GO:0036065","count":1},{"id":"GO:0006486","count":1}]},{"hash":"2222891244727618292","title":"Innate immune response and coagulation","description":"The top GO terms cluster around innate immune defense to bacteria (response to lipopolysaccharide, defense response to Gram-positive bacteria) and hemostasis (blood coagulation, fibrinolysis), with elastin catabolic process tying into tissue remodeling during inflammation. Some development terms appear but are less representative. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0060309","count":1},{"id":"GO:0007596","count":1}]},{"hash":"875163888183512431","title":"PI3K/AKT signaling and integrin-mediated migration","description":"The cluster\u2019s top GO terms cluster around PI3K/AKT signaling, integrin activation, and GTPase activation, all of which are central to cell adhesion, movement, and related differentiation processes (myoblasts and smooth muscle). The presence of migration/chemotaxis terms (mast cell chemotaxis, adult locomotory behavior) supports a theme of signaling pathways governing cell movement and adhesion rather than a single enzyme or tissue-specific function. Obsolete terms can be ignored for core interpretation. ","confidence":"Medium","size":9,"edges":14,"triangles":7,"max_degree":7,"top_function":"wound healing","top_go_terms":[{"id":"GO:0043491","count":6},{"id":"GO:0008344","count":6},{"id":"GO:0033622","count":6},{"id":"GO:0090630","count":6},{"id":"GO:0043552","count":5}]},{"hash":"2073060111586901108","title":"Unknown","description":"The terms span neural barrier formation (glial BBB), skin barrier, cell adhesion, transporter/trafficking processes, immune cytotoxicity, actin contraction, osteoclast regulation, and even bacterial peptidoglycan catabolism, with no single unifying function evident across the cluster. This lack of a coherent theme suggests the proteins do not share a common, specific role detectable from the GO terms alone.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060857","count":2},{"id":"GO:0016338","count":1},{"id":"GO:0001913","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0034394","count":1}]},{"hash":"543247834354523512","title":"Neural crest and craniofacial development","description":"This cluster centers on neural crest derivatives and craniofacial structures, highlighted by neural crest formation, roof of mouth development, semicircular canal formation, and septum secundum/mesodermal fate terms, with supporting neuroendocrine context (pituitary and parasympathetic nervous system development) and broader transcriptional regulation during development.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0060021","count":7},{"id":"GO:0014029","count":6},{"id":"GO:0021920","count":6},{"id":"GO:0045686","count":6}]},{"hash":"338109095019938161","title":"Integrin signaling with cytoskeletal remodeling in immune cells","description":"The top GO terms center on integrin-mediated signaling, cell adhesion and spreading, and cytoskeletal-associated processes, with supporting roles in neutrophil chemotaxis, phagocytosis, and responses to PDGF and LDL. Rho and Ras pathway regulation point to cytoskeletal dynamics and signaling modulation, all consistent with adhesive and migratory functions of immune cells and associated phagocytic activity. While a B cell differentiation term is present, the dominant theme is integrin-driven adhesion and cytoskeletal remodeling in immune cells, making this label representative of the cluster.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0051092","count":4},{"id":"GO:0030593","count":4},{"id":"GO:0036120","count":4},{"id":"GO:0006909","count":4}]},{"hash":"1567595194893471425","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":12,"triangles":4,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0070389","count":4},{"id":"GO:0006986","count":4}]},{"hash":"849504574487716067","title":"Vertebrate Development and Morphogenesis","description":"The top GO terms point to broad developmental and morphogenetic processes across tissues: retinoic acid signaling, angiogenesis, adipocyte differentiation, neuron axonogenesis, placental and facial development, and cartilage growth. Together these reflect vertebrate embryonic development and tissue patterning rather than a specific, single-function pathway, making a vertebrate development/morphogenesis label appropriate. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071300","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0045444","count":3},{"id":"GO:0021952","count":3},{"id":"GO:0038066","count":3}]},{"hash":"1106576086282832678","title":"Ubiquitin-dependent proteolysis and JNK/GTPase signaling","description":"The cluster shows enrichment for multiple ubiquitination-related terms (ubiquitin-dependent protein catabolic process, autoubiquitination, monoubiquitination, K63-linked ubiquitination, and regulation of ubiquitin-dependent proteolysis) and for regulation of JNK cascades and GTPase activity, pointing to proteins that modulate turnover and signaling via ubiquitination. The presence of a microtubule localization term suggests roles in trafficking, while a couple of broader terms (placenta morphogenesis, intracellular transport of viral material) may reflect contextual functions in development or antiviral responses. Overall, these proteins appear connected through ubiquitin-mediated regulation of protein stability and signaling pathways.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0051865","count":4},{"id":"GO:0046328","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0060669","count":3}]},{"hash":"1594803374058321659","title":"Neural and Visual System Development","description":"The top GO terms cluster around neural development and sensory systems: axonogenesis, excitatory postsynaptic potential, Schwann cell development, and visual perception point to neuronal growth and maturation, including supporting glia and sensory structures. Other terms like heart development and cell-cycle regulation reflect broader developmental processes that can appear across tissues, while abscisic acid signaling seems unrelated (likely noise). Overall, the common theme is neural development with visual system involvement.","confidence":"Medium","size":8,"edges":7,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0043065","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0007507","count":5}]},{"hash":"1078856862368188292","title":"Amino Acid Biosynthesis and Vitamin B6 Metabolism","description":"The cluster centers on metabolic processes: amino acid biosynthesis (leucine, lysine), the tricarboxylic acid cycle, and pyridoxine (vitamin B6) biosynthesis, with supporting roles in iron-sulfur cluster maturation and related cofactor metabolism. A Notch signaling term appears among the top terms, but the dominant signal is core metabolism and vitamin/cofactor production, suggesting these proteins work together in amino acid and cofactor biosynthesis pathways rather than a single signaling cascade.","confidence":"Medium","size":8,"edges":25,"triangles":39,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0009098","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0034516","count":3}]},{"hash":"239977938304725746","title":"Unknown","description":"The top GO terms span diverse themes\u2014morphogenesis in multiple tissues (dendrite, outer ear, mammary gland), signaling responses (prostaglandin, PMA), leukocyte chemotaxis regulation, sterol import, DNA repair, and cyclic nucleotide biosynthesis\u2014without a single unifying function. The lack of edges also suggests no tight connectivity, so a specific, representative label cannot be confidently assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":8},{"id":"GO:1990804","count":8},{"id":"GO:0033598","count":8},{"id":"GO:0002688","count":8},{"id":"GO:0071380","count":8}]},{"hash":"302353845300334444","title":"Translation Machinery and Ribosome Biogenesis","description":"The top GO terms are dominated by translation-related processes, including translation (GO:0006412), ribosomal large subunit assembly (GO:0000027), and translational termination (GO:0006415), indicating the cluster largely represents ribosome biogenesis and protein synthesis machinery, with supporting signals from tRNA modification and related translation steps.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000027","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0006415","count":2},{"id":"GO:0006071","count":1}]},{"hash":"105478245331426717","title":"Neuroimmune signaling and defense","description":"This cluster shows a mix of neural development and function terms (corpus callosum development, positive regulation of synapse assembly, behavioral response to pain) alongside immune and antiviral/antibacterial response terms (defense response to Gram-positive bacterium, response to dsRNA, LPS signaling, interferon-beta production, xenophagy). The convergence of neural and immune pathway terms suggests proteins involved in neuroimmune cross-talk and regulation of neural processes by immune signaling, or vice versa. Confidence: Medium","confidence":"","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0043330","count":5},{"id":"GO:0022038","count":5},{"id":"GO:1904417","count":5},{"id":"GO:0061368","count":5}]},{"hash":"1613541492742743339","title":"Melanosome trafficking and vesicle transport","description":"Multiple terms point to coordinated trafficking of pigment-containing organelles: ER-to-Golgi and endosome-to-melanosome transport, melanosome assembly, and protein localization to endosomes. Additional terms for vesicle docking and tubulin-based transport support a broader vesicle transport role necessary for melanosome biogenesis and localization. Overall, the cluster likely reflects melanosome biogenesis and vesicular transport processes.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:1903232","count":2},{"id":"GO:0034976","count":2},{"id":"GO:0035646","count":2},{"id":"GO:0036010","count":2}]},{"hash":"1970660732252940496","title":"Innate Immune Signaling and Lymphangiogenesis","description":"Based on the top GO terms, the cluster shows strong enrichment for innate immune receptor signaling pathways (stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, response to fungal origin) and immune cell regulation (NK cell chemotaxis), with additional terms related to lymphatic vessel morphogenesis. While there are a few development-focused terms (mesonephric/metanephric morphogenesis), the dominant signal is innate immune signaling and related immune cell activity, making this a coherent label. ","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":7},{"id":"GO:0060355","count":7},{"id":"GO:0036303","count":7},{"id":"GO:0072287","count":7},{"id":"GO:0071226","count":7}]},{"hash":"74745373218613290","title":"BMP/TGF-\u03b2 signaling in osteochondral and palatal development","description":"The proteins in this cluster are enriched for osteoblast and chondrocyte differentiation, roof of mouth development, and regulation of BMP/TGF-\u03b2 signaling, indicating a cohesive role in skeletal development and palatogenesis via BMP/TGF-\u03b2/SMAD pathways, with both positive and negative regulatory influences.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045669","count":4},{"id":"GO:0002062","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0030514","count":3},{"id":"GO:0030513","count":3}]},{"hash":"2231247997272479495","title":"Diverse metabolite biosynthesis","description":"The cluster shows enrichment for multiple biosynthetic and metabolic processes across diverse metabolites (androgen/testosterone biosynthesis, sphinganine metabolism, phylloquinone, tetrahydrobiopterin, retinal and melanin biosynthesis, antibiotic biosynthesis), suggesting a broad biosynthesis/metabolism theme rather than a single pathway. Some annotations like lung development are incidental. Confidence: Medium.","confidence":"","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":8},{"id":"GO:0006666","count":8},{"id":"GO:0042376","count":8},{"id":"GO:0061370","count":8},{"id":"GO:0017000","count":8}]},{"hash":"366113591024651116","title":"Actin Cytoskeleton Regulation","description":"The top GO terms show clear links to actin cytoskeleton dynamics: actin filament bundle assembly, actomyosin structure organization, and negative regulation of actin filament depolymerization. Motor neuron axon guidance also depends on cytoskeletal remodeling, supporting a common theme of cytoskeletal regulation. Some terms appear unrelated (developmental or organism-specific processes), suggesting pleiotropic annotations, but the dominant signal points to actin-related regulation.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000346","count":7},{"id":"GO:0046013","count":7},{"id":"GO:0048482","count":7},{"id":"GO:0030835","count":7},{"id":"GO:2000744","count":7}]},{"hash":"2292070757497138846","title":"Vesicle Trafficking and Endocytosis Regulation","description":"The terms cluster around endocytosis and vesicle exocytosis (receptor-mediated endocytosis, vesicle fusion, synaptic/dopamine secretion) with ubiquitin-dependent processes and Rho signaling, plus immune and muscle differentiation contexts, suggesting a common theme of regulating vesicle trafficking and membrane fusion across diverse cell types.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048260","count":4},{"id":"GO:0031340","count":4},{"id":"GO:0002669","count":4},{"id":"GO:2000300","count":4},{"id":"GO:0002316","count":4}]},{"hash":"1734767854979451849","title":"Neuronal development and neurotransmitter metabolism","description":"This cluster contains terms tied to nervous system development and function (dendrite morphogenesis, CNS neuron development, locomotory behavior) and to neurotransmitter metabolism (dopamine), plus corroborating nucleotide metabolism (AMP/uracil salvage, PRPP biosynthesis, glutamine metabolism) that can support neural activity. The combination suggests a theme of neuron development with neurometabolic activity, though lactation is an outlier. ","confidence":"Medium","size":8,"edges":21,"triangles":26,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0044209","count":5},{"id":"GO:0046110","count":3},{"id":"GO:0048813","count":3},{"id":"GO:0007595","count":3},{"id":"GO:0021954","count":3}]},{"hash":"1946328146941080216","title":"Golgi-Associated Vesicle Trafficking","description":"These proteins are enriched for steps in the secretory pathway: ER-to-Golgi transport, Golgi retention/localization, and Golgi-to-plasma membrane/endosome trafficking. Although a couple of terms touch brain development and neuronal signaling, the dominant theme is Golgi-related vesicular transport and localization, supporting this label.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0031505","count":1},{"id":"GO:0045053","count":1},{"id":"GO:0006486","count":1}]},{"hash":"689258094429673985","title":"Translation and tRNA aminoacylation","description":"The cluster is dominated by GO terms for translation (GO:0006412) and multiple tRNA aminoacylation processes (lysyl, aspartyl, mitochondrial variants), indicating core involvement in protein synthesis and tRNA charging; a few terms about telomere localization and DNA recombination appear but are less central.","confidence":"High","size":8,"edges":12,"triangles":5,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0071915","count":4},{"id":"GO:0072581","count":4},{"id":"GO:0070200","count":4},{"id":"GO:0006310","count":4}]},{"hash":"1101157410257778481","title":"Unknown","description":"The GO terms are heterogeneous across organisms and processes (adhesion/polarity in epithelial contexts, insect and plant development, and even mitosis), with no single dominant function tying the proteins together, so a coherent, representative label cannot be confidently assigned.","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007100","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0030311","count":2},{"id":"GO:0001744","count":2}]},{"hash":"2034490188466178849","title":"Erythrocyte maturation and nitric oxide oxidative stress signaling","description":"These proteins show strong enrichment for erythrocyte differentiation/enucleation and nitric oxide transport/biosynthesis, along with oxidative and nitrosative stress responses and related detoxification. There is also a cardiovascular context (heart development, coagulation), but the clearest shared theme centers on red blood cell maturation and NO-mediated redox regulation. This supports a label focused on erythrocyte development coupled with NO-oxidative stress signaling.","confidence":"Medium","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0009636","count":6},{"id":"GO:0007596","count":5},{"id":"GO:0043353","count":5},{"id":"GO:0042542","count":5}]},{"hash":"1265754753302289386","title":"Embryonic cardiovascular and limb morphogenesis","description":"The terms cluster around developmental processes, especially morphogenesis of cardiovascular structures (pulmonary and aortic valve morphogenesis, glomerular capillary formation, pericardium morphogenesis) and limb morphogenesis, with negative regulation of angiogenesis and related growth regulation (osteoblast differentiation). A notable outlier is complement activation, but the dominant theme is embryonic tissue and vessel/valve development. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0030326","count":3},{"id":"GO:0072104","count":3},{"id":"GO:0003344","count":3}]},{"hash":"1480110019854177056","title":"Fatty acid catabolism cluster","description":"This cluster\u2019s top GO terms concentrate on fatty acid metabolism, especially fatty acid catabolic processes and fatty-acyl-CoA catabolic steps (including medium- and long-chain). This points to a core role in lipid energy metabolism. Some terms (like mitochondrial translation and ER organization) seem less coherent with metabolism and may reflect annotation noise, but the fatty-acid metabolism signals dominate the set.","confidence":"Medium","size":8,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":2},{"id":"GO:0019876","count":2},{"id":"GO:0009062","count":2},{"id":"GO:0070681","count":2},{"id":"GO:0007029","count":2}]},{"hash":"184324808619655868","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006620","count":2},{"id":"GO:0051083","count":2},{"id":"GO:1901726","count":2},{"id":"GO:0048513","count":2},{"id":"GO:2000864","count":2}]},{"hash":"1223770884485222649","title":"Cardiovascular and embryonic development","description":"The top GO terms cluster around heart development, angiogenesis, and ventricular heart morphogenesis, along with related embryonic processes like limb development and gonadal/adrenal organ development, suggesting these proteins function in broader embryonic organogenesis with a strong cardiovascular emphasis.","confidence":"High","size":8,"edges":8,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0045720","count":4},{"id":"GO:0007566","count":4},{"id":"GO:0030325","count":4},{"id":"GO:0008584","count":4}]},{"hash":"406146875714252696","title":"Secretory vesicle trafficking","description":"The GO terms cluster around vesicle transport and fusion along the secretory pathway, including ER-to-Golgi transport, Golgi ribbon formation, vesicle fusion with the Golgi, mucus secretion, synaptic vesicle exocytosis, and neutrophil degranulation, indicating a cohesive role in secretion and intracellular transport of cargo. The prominence of exocytic and secretory processes across diverse cell types supports a unifying label focused on secretory vesicle trafficking.","confidence":"High","size":8,"edges":10,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0070254","count":3},{"id":"GO:0016240","count":3},{"id":"GO:0090316","count":3},{"id":"GO:0090161","count":3}]},{"hash":"1039942111872713178","title":"Cytoskeleton dynamics and vesicle trafficking regulation","description":"The cluster centers on actin organization, cytoskeletal signaling (Rho/Ras), and vesicle-related processes (synaptic vesicle priming, intracellular transport, acrosome reaction), suggesting coordinated regulation of cytoskeleton remodeling with vesicle trafficking and exocytosis. While some terms touch on more specialized contexts (mating projection growth, blood vessel remodeling), the shared theme is cytoskeleton-driven transport and secretion.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0006886","count":2}]},{"hash":"1843705295975543265","title":"Leukocyte adhesion and lymphocyte differentiation","description":"This cluster is dominated by immune-related terms, notably leukocyte tethering or rolling and heterophilic cell-cell adhesion, along with B cell differentiation and CD8-positive T cell differentiation, indicating a core theme of leukocyte interaction and lymphocyte development. Additional terms referencing tissue-specific processes appear incidental to the main immune-focused functions.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050901","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0035509","count":1},{"id":"GO:0030183","count":1},{"id":"GO:0030730","count":1}]},{"hash":"1699464806163913887","title":"RNA metabolism and neural development","description":"Top terms point to RNA processing and translation (translation, stress granule assembly, deadenylation-dependent decay, mRNA processing body regulation) plus hints of nervous system development and plasticity (olfactory learning, photoreceptor development, synapse structural plasticity). The overlap suggests a cluster where RNA metabolism intersects with neural/sensory development pathways.","confidence":"Medium","size":8,"edges":7,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0010603","count":3},{"id":"GO:0022416","count":3},{"id":"GO:0034063","count":3},{"id":"GO:1900153","count":3}]},{"hash":"1417596772447089503","title":"Developmental cell adhesion and organogenesis","description":"The cluster centers on cell\u2013cell adhesion (heterophilic/homophilic) and multiple organogenesis-related processes, including bone ossification, nervous system development and synapse assembly, and cardiac structures (endocardial cushion, mitral valve), along with mesenchymal proliferation. This suggests a cohesive group of proteins mediating developmental tissue morphogenesis through adhesion signaling.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007156","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0051965","count":5}]},{"hash":"2082425775512913798","title":"Multi-tissue developmental morphogenesis","description":"This cluster centers on developmental and morphogenetic processes across multiple tissues (heart, bone, nervous system, and Sertoli barrier), as reflected by terms like outflow tract morphogenesis, corticospinal tract morphogenesis, ossification in bone maturation, and establishment of Sertoli cell barrier; a few chromatin-related terms appear but are less central.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046598","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0003151","count":2}]},{"hash":"2042746924247123738","title":"DNA Damage Response and Chromatin Remodeling","description":"The top GO terms cluster around chromatin dynamics and transcription control (nucleosome disassembly, transcription initiation-coupled remodeling, negative regulation of transcription by RNA pol II) and DNA damage response signaling (p53-related pathways) with cell-cycle transition aspects (G0 to G1). While some development terms appear, the dominant pattern is a chromatin-regulated stress response influencing transcription and DNA damage signaling, justifying this label.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":1},{"id":"GO:0016567","count":1},{"id":"GO:0045023","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0003407","count":1}]},{"hash":"246311875581550129","title":"Neuronal adhesion and axon guidance","description":"Proteins in this cluster are enriched for cell adhesion molecules (homophilic/heterophilic adhesion) and neuron development cues, including trigeminal nerve structure, sympathetic neuron projection extension and guidance, branchio-motor neuron axon guidance, and collateral sprouting. Immune-related terms appear but are less central to the main theme of neuronal wiring and adhesion.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0021637","count":5},{"id":"GO:0097490","count":5},{"id":"GO:0021785","count":5}]},{"hash":"1686822089593047789","title":"Spliceosome Assembly and Translation Initiation","description":"Most of the top GO terms point to mRNA splicing and spliceosome assembly (cis splicing, splice site recognition, processome assembly, alternative splicing, and preinitiation complex formation), plus terms related to translation initiation complex assembly, indicating a cluster centered on RNA processing and translation readiness.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0045292","count":2},{"id":"GO:0034462","count":2},{"id":"GO:0006376","count":2},{"id":"GO:0097010","count":2}]},{"hash":"1602415872298613199","title":"Cardiac Muscle Contraction and Sarcomere Organization","description":"This cluster centers on heart-related contractile processes: cardiac muscle contraction, sarcomere organization, and regulation of heart rate by epinephrine, pointing to cardiac/muscle physiology. While a spicule insertion term and some phototransduction/visual perception annotations appear, the dominant theme is cardiac muscle function and vascular smooth muscle regulation, suggesting a cohesive sarcomere- and heart-focused cluster.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":8},{"id":"GO:0060298","count":7},{"id":"GO:0003065","count":7},{"id":"GO:0045214","count":7},{"id":"GO:0034609","count":7}]},{"hash":"1596945608771683003","title":"Epigenetic regulation of development","description":"These proteins show a pattern linking developmental processes (heart and gland development, brood size regulation) with chromatin dynamics (nucleosome assembly/disassembly) and histone modification (H3-K36 dimethylation), as well as growth-related signaling (insulin receptor pathway, G1/S cell cycle control). Despite some immune-related terms, the dominant theme is epigenetic control of development and growth.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0097676","count":2},{"id":"GO:0006337","count":2},{"id":"GO:1903699","count":2}]},{"hash":"573145556573567616","title":"Embryonic organogenesis with immune development","description":"This cluster\u2019s terms are largely about developmental and organogenesis processes across multiple tissues (mesendoderm development, osteoblast differentiation, ureteric bud branching, pituitary gland development, chorio-allantoic fusion, maternal parturition), with a subset related to immune system maturation (T cell homeostasis, thymic T cell proliferation). The common theme is broad embryonic/organ development, with some immune development represented.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":3},{"id":"GO:0048535","count":3},{"id":"GO:0060710","count":3},{"id":"GO:0048382","count":3},{"id":"GO:0001649","count":3}]},{"hash":"472018549742288242","title":"Immunological synapse signaling and actin remodeling","description":"The cluster combines immune signaling (regulation of NK/T cell activity, phagocytosis signaling, defense against bacteria) with cytoskeleton and cell junction remodeling (actin organization, synapse assembly, protein localization to cell junctions), pointing to immunological synapse formation and immune cell\u2013cell interactions.","confidence":"Medium","size":8,"edges":26,"triangles":44,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043318","count":3},{"id":"GO:0051963","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0090138","count":3},{"id":"GO:0002859","count":3}]},{"hash":"2045327319711558183","title":"Embryonic Development and Tissue Morphogenesis","description":"Top GO terms cluster around diverse embryonic development processes across multiple tissues (palate, placenta, heart via endocardial cushion EMT, cartilage, hair follicle morphogenesis, left-right patterning) and general morphogenesis, indicating a broad developmental/tissue formation function rather than a single pathway.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0035270","count":5}]},{"hash":"943564774634552836","title":"Innate Immune Signaling and Actin Remodeling","description":"The top terms cluster around innate immune pathways (TLR2 signaling, Toll signaling pathway, innate immune response, IL-8 production) and actin cytoskeleton dynamics (actin filament network formation, regulation of barbed-end actin filament capping), suggesting proteins that coordinate immune activation with cytoskeletal remodeling. Some terms appear ancillary (e.g., floral organ development, neural signaling), but the dominant theme is innate immunity coupled with actin remodeling.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090394","count":3},{"id":"GO:0051770","count":3},{"id":"GO:0051639","count":3},{"id":"GO:0034134","count":3},{"id":"GO:0048833","count":3}]},{"hash":"1849027847044458271","title":"Sweet taste GPCR signaling","description":"The top GO terms are dominated by sensory perception of sweet taste and GPCR signaling linked to metabotropic glutamate receptors (including PLC-activating and adenylyl cyclase-inhibiting pathways), suggesting proteins that participate in taste-related GPCR signaling. Terms like conditioned taste aversion reinforce a taste-related role, though a few unrelated terms (defense response to bacterium, peptidoglycan catabolic process) may reflect annotation noise. Overall, the cluster appears centered on taste-associated GPCR signaling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001582","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0007196","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0007206","count":3}]},{"hash":"791510784676657729","title":"Metabolism and Detoxification","description":"Most frequent GO terms cluster around metabolic processing of diverse substrates\u2014cellulose catabolism, the beta-ketoadipate pathway, choline metabolism, and cholesterol ester hydrolysis\u2014plus cellular oxidant detoxification, suggesting a metabolic/detox role for the proteins. Some terms (retina development, signaling, neurotransmitter biosynthesis) are peripheral and less clearly connected, but do not override the primary metabolic theme. Therefore, the label \"Metabolism and Detoxification\" best captures the core function of this cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030245","count":6},{"id":"GO:0042952","count":5},{"id":"GO:0098869","count":5},{"id":"GO:0090122","count":4},{"id":"GO:0009939","count":4}]},{"hash":"1924797625954605805","title":"Ribosome Biogenesis and Translation","description":"Most top GO terms point to ribosome production and function: ribosome biogenesis, cytoplasmic translation, tRNA modification, and ribosomal large subunit export from nucleus. These indicate a cluster of proteins involved in the ribosome assembly and protein synthesis machinery. The other terms (cell cycle/division) may reflect indirect links to growth and division, or annotation noise, but do not override the central ribosome-focused theme.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0042832","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0006400","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0007049","count":4}]},{"hash":"442675579542479985","title":"Cholesterol transport and lipoprotein remodeling","description":"Based on GO terms such as regulation of intestinal cholesterol absorption, cholesterol efflux, HDL/LDL particle remodeling, HDL particle assembly, and phospholipid efflux, the cluster is best described as related to cholesterol transport and lipoprotein metabolism. While some terms touch on xenobiotic response and protein oxidation, the core signal centers on lipoprotein remodeling and cholesterol homeostasis.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030300","count":3},{"id":"GO:0018158","count":3},{"id":"GO:0010903","count":3},{"id":"GO:0002740","count":3},{"id":"GO:0034384","count":3}]},{"hash":"1015863668930864769","title":"Bacterial acetylation and osmolyte biosynthesis","description":"The Top Terms show a clear emphasis on acetylation-related processes (N-terminal peptide acetylation, putrescine/spermine acetylation) alongside osmolyte biosynthesis (ectoine, mycothiol) and related sugar metabolism (glucosamine). Together these suggest a coherent theme of acetyltransferase-driven modifications and osmoprotectant pathways in bacteria, likely actinobacteria.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":8},{"id":"GO:0019491","count":8},{"id":"GO:0017196","count":8},{"id":"GO:0032920","count":8},{"id":"GO:0006044","count":8}]},{"hash":"536141113651763203","title":"DNA Replication and Cell Cycle Regulation","description":"The terms cluster around DNA replication, cell cycle transitions (G1/S), and chromosome/kinetochore activities (kinetochore localization, meiotic cell cycle, DNA-templated transcription), suggesting a core role in genome maintenance and cell division. Some terms point to neural development or signaling contexts (Schwann cell development, excitatory postsynaptic potential, response to cocaine, dsRNA response, glucose signaling), but they appear ancillary to the dominant replication/cell cycle theme.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042220","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0014044","count":5},{"id":"GO:0051321","count":5},{"id":"GO:0060079","count":5}]},{"hash":"323225408953707892","title":"Neuronal actin dynamics and neurite outgrowth","description":"This cluster is enriched for GO terms tied to actin cytoskeleton remodeling (actin filament network formation, lamellipodium morphogenesis) and neuronal development processes (dendrite extension, floor plate development, response to brain-derived neurotrophic factor). The combination suggests proteins coordinating actin-driven neurite outgrowth and neuronal maturation, with some mitochondrial fission regulation appearing as a supporting context.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090140","count":3},{"id":"GO:0044397","count":3},{"id":"GO:1990416","count":3},{"id":"GO:0051639","count":3},{"id":"GO:0031643","count":3}]},{"hash":"112214821380606637","title":"Proteostasis and organelle biogenesis under stress","description":"The cluster\u2019s GO terms cluster around protein turnover and quality control (autophagosome maturation, proteasomal protein catabolic process, stress granule disassembly, inclusion body assembly) alongside organelle biogenesis/maintenance (mitochondrial respiratory chain complex III assembly, peroxisome matrix protein import, receptor recycling). This points to a theme of cellular stress responses coupled with maintenance of organelles, with terms like cellular heat acclimation supporting the stress angle. A fertilization-related term appears but does not define the cluster\u2019s core function.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007339","count":2},{"id":"GO:0097352","count":2},{"id":"GO:0016562","count":2},{"id":"GO:0035617","count":2},{"id":"GO:1901800","count":2}]},{"hash":"2215258592861211942","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009116","count":5},{"id":"GO:0006541","count":5},{"id":"GO:0006015","count":4},{"id":"GO:0016310","count":4},{"id":"GO:0031100","count":4}]},{"hash":"2172698418365599165","title":"Neuronal ion transport and morphogenesis","description":"The top GO terms cluster around neuronal activity: potassium ion transport and export, dendrite morphogenesis, and sensory perception of pain, with supporting signals from development and transcriptional processes. While there are a few unrelated terms, the strongest signals point to neuronal signaling and morphogenesis, making this a coherent label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006813","count":7},{"id":"GO:0048813","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0046827","count":6},{"id":"GO:0007275","count":6}]},{"hash":"1167686315292164095","title":"Unknown","description":"The terms span cartilage development, immune and fungal-origin responses, insulin secretion regulation, PDGF/PI3K-AKT signaling, cell-cell signaling, apoptotic regulation, long-term synaptic potentiation, placenta development, and LPS response. This broad mix shows no single, cohesive function linking all proteins, so a precise, intuitive label isn\u2019t evident beyond Unknown.","confidence":"","size":7,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":4},{"id":"GO:0071226","count":3},{"id":"GO:0046676","count":2},{"id":"GO:0051897","count":2},{"id":"GO:0007267","count":2}]},{"hash":"1888709597617634046","title":"Proteoglycan biosynthesis and tissue morphogenesis","description":"This cluster is driven by proteoglycan biosynthesis (chondroitin sulfate, heparan sulfate) and tissue morphogenesis terms (lens maintenance, kidney morphogenesis), pointing to an ECM/proteoglycan\u2013related role in organ development and tissue organization; the other terms (thyroid hormone metabolism, insulin response, intestinal absorption) appear peripheral but may reflect broader metabolic context.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":2},{"id":"GO:0034116","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0050650","count":2},{"id":"GO:0015012","count":2}]},{"hash":"808525771951793838","title":"Spliceosome and RNA Processing Machinery","description":"This cluster is dominated by GO terms tied to RNA splicing and processing, including spliceosomal complex assembly, spliceosomal snRNP assembly, mRNA cis splicing via spliceosome, and related RNA maturation/decapping steps, plus tRNA processing and rRNA maturation. The convergence on splicing machinery and broader RNA-processing activities suggests these proteins function together as core components of RNA processing and splicing pathways. The label thus reflects the central theme of the cluster, with a minor representation of associated transcription termination and chromatin-related terms that can accompany RNA-processing complexes.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":5},{"id":"GO:0000245","count":5},{"id":"GO:1990141","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0000290","count":5}]},{"hash":"1737887941722192824","title":"Axonogenesis and Neurogenesis Signaling","description":"The cluster is dominated by neural-development related GO terms: positive regulation of axonogenesis and neurogenesis, along with regulation of axon extension and paranode localization, plus signaling through receptor tyrosine kinases, PI3K/AKT, and BMP pathways. This points to coordinated signaling governing neural growth, axon patterning, and neuronal differentiation, with some balancing negative regulations. Overall, the proteins likely function in neural development and axon guidance.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048692","count":6},{"id":"GO:1902997","count":6},{"id":"GO:0050772","count":6},{"id":"GO:0050925","count":6},{"id":"GO:0007169","count":6}]},{"hash":"1436307446565560522","title":"C-type lectin and Fc receptor signaling","description":"Top terms indicate receptor-mediated signaling in immune cells, with emphasis on C-type lectin receptors and Fc-gamma receptors, basophil activation, and NK cell regulation, suggesting a cohesive theme of innate immune sensing and leukocyte activation; the kidney and lymphatic morphogenesis terms are less central to this cluster but may reflect broader developmental contexts. ","confidence":"High","size":7,"edges":18,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":6},{"id":"GO:0060355","count":6},{"id":"GO:0036303","count":6},{"id":"GO:0072287","count":6},{"id":"GO:0071226","count":6}]},{"hash":"1508386448836634945","title":"COPI-mediated ER-Golgi trafficking","description":"The top GO terms cluster around COPI-coated vesicle budding and transport between the endoplasmic reticulum and Golgi, along with ER retention and regulation of protein exit from the ER. While a few developmental terms appear (axis specification, egg-laying behavior), the dominant signal is COPI vesicle\u2013mediated trafficking in the early secretory pathway, which the proteins likely share. This label succinctly captures the core function of the cluster.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035964","count":2},{"id":"GO:0006621","count":2},{"id":"GO:0007311","count":2},{"id":"GO:0070863","count":2},{"id":"GO:0032525","count":2}]},{"hash":"1450813474499772646","title":"Heart and vascular development signaling","description":"The top GO terms strongly point to heart development and endothelial barrier establishment, with supporting evidence for mechanotransduction and vascular remodeling (cell signaling pathways like Rho and KIT). Although some terms relate to immune signaling or cell death, the dominant theme is cardiovascular development and vascular signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0097527","count":3},{"id":"GO:0035234","count":3}]},{"hash":"638907206620396056","title":"Acetyl-CoA metabolism and fatty acid biosynthesis","description":"The top GO terms cluster around acetyl-CoA production and its use in biosynthetic pathways: pyruvate decarboxylation to acetyl-CoA, malonyl-CoA biosynthesis, long-chain fatty acid biosynthesis, TCA cycle, and gluconeogenesis, with amino acid catabolism (leucine, lysine) feeding into acetyl-CoA. Translation is present but secondary to the central theme of acetyl-CoA flux and lipid biosynthesis, suggesting a cohesive metabolic module rather than a functionally mixed group.","confidence":"High","size":7,"edges":7,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:2001295","count":3},{"id":"GO:0033512","count":3},{"id":"GO:0042759","count":3},{"id":"GO:0006099","count":2}]},{"hash":"1970727316201241959","title":"Translation and ribosome assembly","description":"Dominated by translation (GO:0006412) and ribosome assembly (GO:0042255), with some ancillary terms related to transcription regulation and iron-sulfur cluster maturation. The primary pattern points to protein synthesis machinery and ribosome biogenesis, making this the most representative theme for the cluster.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0016226","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0017148","count":1},{"id":"GO:0060702","count":1}]},{"hash":"1439052952066205058","title":"Bacterial polysaccharide and cell wall biosynthesis","description":"This cluster is dominated by GO terms tied to the biosynthesis of cell wall-related polysaccharides (UDP-N-acetylglucosamine, GDP-mannose, lipopolysaccharide and O antigen biosynthesis) and carbohydrate metabolism (glucose-1-phosphate, glycogen). Together these terms point to a coordinated program for assembling and modifying cell envelope components in bacteria. A few outlier terms like detection of gravity likely reflect annotation noise rather than a true functional shift. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006048","count":2},{"id":"GO:0071555","count":2},{"id":"GO:0046115","count":2},{"id":"GO:0006148","count":2},{"id":"GO:0009590","count":2}]},{"hash":"1906770087280285183","title":"Endocrine Signaling and Renal Homeostasis","description":"The top GO terms cluster around endocrine signaling (gonad development, androgen metabolism, thyroid hormone response, JAK-STAT signaling) and kidney/homeostasis processes (renal water homeostasis, renal system development, tissue homeostasis), suggesting a shared role in hormonal regulation of renal and systemic balance.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":7},{"id":"GO:0046427","count":7},{"id":"GO:0008209","count":7},{"id":"GO:0003091","count":7},{"id":"GO:0001894","count":7}]},{"hash":"1615922777050557543","title":"Metabolic Biosynthesis and Catabolic Pathways","description":"The top GO terms are dominated by biosynthetic and catabolic processes (menaquinone and phylloquinone biosynthesis, antibiotic biosynthesis, phenylacetate and valine catabolism, fatty acid beta-oxidation), indicating a general metabolic/energy-related cluster. A few terms relate to signaling or ubiquitination, which may reflect annotation noise or cross-species annotations, but the core theme remains metabolism.","confidence":"Medium","size":7,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010124","count":1},{"id":"GO:0009234","count":1},{"id":"GO:0042372","count":1},{"id":"GO:0017000","count":1},{"id":"GO:0006574","count":1}]},{"hash":"2284000804103607158","title":"Diverse Biosynthesis and Metabolism","description":"The top terms point to a broad set of biosynthetic and metabolic processes, including hormone (androgen, testosterone) synthesis, lipid/sphingolipid metabolism, vitamin/phytochemical biosynthesis (phylloquinone, tetrahydrobiopterin), pigment synthesis (melanin, retinal), and even antibiotic production. This suggests a general theme of diverse biosynthetic and metabolic activities rather than a single cohesive function or pathway, though the cluster collectively centers on synthesis and processing of biomolecules. ","confidence":"Medium","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":7},{"id":"GO:0006666","count":7},{"id":"GO:0042376","count":7},{"id":"GO:0061370","count":7},{"id":"GO:0017000","count":7}]},{"hash":"1191339921205017742","title":"Osteogenesis and ECM adhesion","description":"This cluster is dominated by terms for bone formation and extracellular matrix interactions, including osteoblast differentiation, bone trabecula formation, collagen fibril organization, and various cell-ECM adhesion processes (integrin, hemidesmosomes, cell-matrix adhesion). The presence of positive regulation of smoothened signaling (Hedgehog pathway) aligns with developmental signaling that promotes osteogenesis. Although a term about dorsal trunk growth appears, the strongest, most frequent signals point to bone formation and ECM organization.","confidence":"High","size":7,"edges":10,"triangles":5,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":4},{"id":"GO:0033627","count":4},{"id":"GO:0045880","count":4},{"id":"GO:0060346","count":4},{"id":"GO:0045669","count":3}]},{"hash":"1000717007773831027","title":"Retroviral integration and proviral latency","description":"The cluster centers on reverse transcription, DNA integration, and establishment of proviral latency, with terms like RNA-templated DNA biosynthesis, DNA integration, and integrated proviral latency, indicating a retroviral-like life cycle despite some noise from symbiont-related terms.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075732","count":2},{"id":"GO:0006278","count":2},{"id":"GO:0043137","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0090502","count":2}]},{"hash":"983197135612588607","title":"Bacterial Secretion and Flagellar Motility Machinery","description":"The cluster is dominated by GO terms for membrane energy and transport (proton transmembrane transport, proton motive force-driven ATP synthesis, sodium ion transport, vacuolar acidification) and for bacterial motility and secretion (flagellum assembly, flagellum-dependent motility, type III secretion). These together point to a cohesive theme centered on bacterial energy transduction and secretion/motility machinery, with one outlier term (angiogenesis) likely noise. ","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"lipid metabolic process","top_go_terms":[{"id":"GO:0015991","count":5},{"id":"GO:0001525","count":3},{"id":"GO:0030254","count":3},{"id":"GO:0007035","count":3},{"id":"GO:0071973","count":3}]},{"hash":"298184405861926719","title":"Wnt-regulated organogenesis and EMT","description":"The cluster contains several development-focused terms tied to organ morphogenesis and epithelial-to-mesenchymal transition, notably metanephros/ureteric bud morphogenesis and mesenchymal migration, along with regulation of canonical Wnt signaling. This points to a cohesive role in Wnt-driven organ development and EMT processes, with kidney development being a prominent facet among the terms.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001658","count":5},{"id":"GO:0050677","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0070858","count":5}]},{"hash":"970669627866922214","title":"Mitochondria-Linked Placental Development","description":"The top terms revolve around mitochondrial outer membrane permeabilization (a key apoptosis step) and maternal reproductive processes (placenta development and parturition), suggesting a theme of mitochondria-influenced regulation in placental biology and pregnancy-related events. Some secondary terms (autophagy, protein complex stability, and DNA mobility) may reflect broader cellular stress responses or genome dynamics in these tissues, but mitochondria-driven placental processes appear central. ","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097345","count":4},{"id":"GO:0001893","count":4},{"id":"GO:0060137","count":4},{"id":"GO:1903547","count":4},{"id":"GO:0015074","count":3}]},{"hash":"1392380955625483353","title":"Innate immunity and T cell cytokine regulation","description":"The terms cluster around innate immune response, defense against virus, and cytokine regulation (IL-1\u03b2 and IL-17), plus T follicular helper cell differentiation and negative regulation of T cell proliferation, with ubiquitination indicating regulatory control of signaling. Some terms related to bone formation and synaptic transport may be incidental noise, but the dominant theme is immune signaling and cytokine regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0050713","count":3},{"id":"GO:0048490","count":3}]},{"hash":"2217896532271672533","title":"Embryonic heart, brain, and cartilage development","description":"The terms point to multiple developmental processes across organs and tissues (heart/endocardial cushion formation and pericardium, brainstem development, cartilage development, and general morphogenesis like dorsal convergence and EMT). Transcription and DNA replication terms reflect proliferative growth typical of embryogenesis. Together they suggest a cluster representing embryonic organogenesis across heart, vasculature, brain, and skeletal tissues.","confidence":"High","size":7,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048096","count":1},{"id":"GO:0006368","count":1},{"id":"GO:0060030","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0003360","count":1}]},{"hash":"463886387260292939","title":"Vesicle trafficking and secretion","description":"The terms cluster around vesicle biology: Golgi ribbon formation, vesicle fusion with the Golgi and vacuoles, autophagosome docking, intracellular protein transport, synaptic vesicle exocytosis, and neutrophil degranulation. Mucus secretion and insulin response also tie into secretory and trafficking pathways. Together they point to a coherent role in vesicle formation, targeting, and fusion across secretory and degradative processes.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0070254","count":1},{"id":"GO:0016240","count":1},{"id":"GO:0090316","count":1},{"id":"GO:0090161","count":1},{"id":"GO:0048280","count":1}]},{"hash":"1936991066596665021","title":"Lymphocyte signaling and migration","description":"The cluster is dominated by immune-related differentiation terms (NK T cell differentiation, B cell affinity maturation) and by signaling and cytoskeletal dynamics (small GTPase signaling, Rho/Ras regulation, lamellipodium assembly, cell spreading, migration). While insulin signaling and myelin maintenance appear, they are less central, so the overall theme is immune cell signaling coupled to motility and cytoskeletal remodeling.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008286","count":6},{"id":"GO:0001865","count":5},{"id":"GO:0007264","count":5},{"id":"GO:0032287","count":5},{"id":"GO:0035023","count":5}]},{"hash":"756976890150913378","title":"Macrophage-mediated innate immunity","description":"The cluster is dominated by GO terms related to macrophage activity and antibacterial defense (negative regulation of macrophage activation; phagocytosis, recognition; defense response to bacterium), indicating a macrophage/innate immune function. While some terms (surfactant homeostasis, acetylcholine GPCR signaling, fibrinolysis, visual perception, ovarian follicle development) are less directly connected, they do not override the core macrophage-focused theme.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043031","count":2},{"id":"GO:0006910","count":2},{"id":"GO:0000187","count":2},{"id":"GO:0042742","count":2},{"id":"GO:0043129","count":1}]},{"hash":"1703531671428317448","title":"Ubiquitin-Proteasome Pathway and Aggresome Formation","description":"Most top GO terms converge on ubiquitination and proteasomal degradation (autoubiquitination, K48- and K6-linked polyubiquitination, ubiquitin-dependent protein catabolic process) and include aggresome assembly and ERAD, suggesting proteins in this cluster participate in tagging misfolded proteins for degradation and organizing them for clearance.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:0070936","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0060733","count":3}]},{"hash":"1459896961711479972","title":"Viral life cycle and latency","description":"The top terms cluster around stages of viral infection and replication (uncoating of virus, virion assembly, fusion of viral membranes with host membranes, entry into host) and reverse transcription/proviral latency (RNA-templated DNA biosynthetic process and establishment of integrated proviral latency), with some host\u2013pathogen interaction signals (symbiont entry into host, cellular response to UV-A). Despite a noisy term like sepal formation, the dominant signal corresponds to viral life cycle processes, justifying a label focused on viral entry, replication, assembly, and latency.","confidence":"High","size":7,"edges":9,"triangles":5,"max_degree":5,"top_function":"protein folding","top_go_terms":[{"id":"GO:1901407","count":5},{"id":"GO:0019061","count":4},{"id":"GO:0006278","count":4},{"id":"GO:0071492","count":4},{"id":"GO:0048453","count":4}]},{"hash":"1463456334251155460","title":"Ion and nutrient transmembrane transport","description":"The cluster is dominated by GO terms for transport across membranes of ions (sodium, potassium, nitrite, nitrate) and small nutrients (sialic acid, galactose, fucose, vitamins), indicating a group of membrane transporter proteins dedicated to moving diverse substrates across cellular membranes.","confidence":"High","size":7,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0015739","count":5},{"id":"GO:0015707","count":5}]},{"hash":"1045900964227761580","title":"Unknown","description":"The top GO terms span multiple unrelated biological areas (UV-A response, amyloid-beta metabolism, potassium transport regulation, replicative senescence, neuropeptide signaling, creatinine metabolism, ear development, angiotensin maturation, respiratory system process, calcitonin catabolic process). There is no single cohesive function or pathway that unifies these terms, so a specific label for this cluster cannot be confidently assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071492","count":1},{"id":"GO:0050435","count":1},{"id":"GO:1901380","count":1},{"id":"GO:0090399","count":1},{"id":"GO:0007218","count":1}]},{"hash":"755783876395221054","title":"Multi-tissue developmental differentiation","description":"The top GO terms span brain and inner ear development, radial glial differentiation, nephron development, and other developmental processes across tissues, plus aspects of cell polarity and synaptic organization. This suggests a broad theme of developmental differentiation across multiple organ systems rather than a single, cohesive pathway. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":4},{"id":"GO:0048839","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0045317","count":3},{"id":"GO:0002314","count":2}]},{"hash":"1182455100047525321","title":"Neural adhesion and synapse assembly","description":"The dominant terms are about cell\u2013cell adhesion (homophilic/heterophilic) and postsynaptic organization via neuroligin clustering, pointing to neural cell adhesion and synapse assembly. Additional terms on radial glial differentiation and sensory perception of sound reinforce a neural development theme, while ossification, nephron development, and B cell differentiation may reflect broader or incidental annotations. Overall, the cluster appears centered on neural adhesion and synapse-related functions.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0007626","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0043931","count":3}]},{"hash":"111937353285604582","title":"Unknown","description":"The top GO terms cover a wide and seemingly unrelated set of processes (behavioral fear response, necroptotic ripoptosome assembly, wing morphogenesis, glycerol metabolism, redox/homeostasis, ubiquitin recycling, transsulfuration, and mRNA processing body assembly) with no clear shared function or pathway, and there are no interaction edges to suggest a cohesive cluster theme. Therefore, no confident single label can be assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001662","count":1},{"id":"GO:1901026","count":1},{"id":"GO:0008587","count":1},{"id":"GO:0006071","count":1},{"id":"GO:0045454","count":1}]},{"hash":"1121834891052118219","title":"Drosophila development and apoptosis cluster","description":"The top GO terms mix developmental processes (posterior head segmentation; regulation of oskar mRNA translation) with apoptosis-related activities (apoptotic process; regulation of mitochondrial membrane permeability in apoptosis), suggesting a cluster centered on developmental regulation with apoptotic involvement in a Drosophila context. Some RNA processing terms appear (spliceosomal assembly, snoRNA processing, RNase MRP-dependent mRNA decay), which can relate to gene expression control during development. Overall, there is a coherent theme of development-linked regulation and cell death rather than a single canonical pathway.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007427","count":2},{"id":"GO:0006915","count":2},{"id":"GO:1902108","count":2},{"id":"GO:0035289","count":2},{"id":"GO:0046011","count":2}]},{"hash":"1713277208139938729","title":"Proteasome and COP9 Deneddylation Regulation","description":"Most terms point to the ubiquitin-proteasome system and COP9 signalosome: proteasome assembly; proteasome-mediated ubiquitin-dependent protein degradation; deneddylation regulation; COP9 signalosome assembly; deneddylation control. The translation initiation-related terms and NF-kappaB kinase activation hint at cross-talk between degradation and signaling, but the dominant theme is proteostasis regulation via proteasome and COP9/deneddylation machinery.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":1},{"id":"GO:0000338","count":1},{"id":"GO:0043161","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0006446","count":1}]},{"hash":"1094480186850987928","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0032543","count":1},{"id":"GO:0071353","count":1}]},{"hash":"881888204449045237","title":"Ubiquitin-Dependent Proteolysis in Plant Tropisms","description":"Most frequent GO terms point to ubiquitin-dependent protein catabolic process and K33-linked ubiquitination, indicating a cluster centered on ubiquitin-mediated protein turnover. The presence of phototropism and gravitropism terms suggests a plant context where such proteolysis modulates growth responses to light and gravity. Other terms appear ancillary or noisy (mast cell cytokine regulation, renal sodium absorption). Overall this cluster seems best described as ubiquitin-dependent proteolysis with a plant tropism angle, hence the chosen name.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:1990390","count":3},{"id":"GO:0009638","count":3},{"id":"GO:0032764","count":3},{"id":"GO:0009958","count":3}]},{"hash":"1766895650295478392","title":"Spliceosome and mRNA Splicing Regulation","description":"The GO terms point to spliceosome activity and mRNA splice site recognition, suggesting proteins in this cluster are involved in RNA splicing and spliceosome conformational changes. The lone lithium response term is less specific but may reflect broader signaling influences. Overall, the cluster appears to be a set of splicing machinery components.","confidence":"Medium","size":7,"edges":8,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045843","count":3},{"id":"GO:0006376","count":3},{"id":"GO:0010226","count":1},{"id":"GO:0000388","count":1}]},{"hash":"1606211233912556597","title":"Secretory vesicle trafficking and secretion","description":"This cluster shows strong signals for vesicle transport, Golgi-related trafficking, and exocytosis processes (including mucus secretion, synaptic vesicle exocytosis, and neutrophil degranulation), pointing to a shared role in the secretory pathway and vesicle trafficking from the Golgi to membranes. ","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":2},{"id":"GO:0070254","count":2},{"id":"GO:0016240","count":2},{"id":"GO:0090316","count":2},{"id":"GO:0090161","count":2}]},{"hash":"1630865237873104816","title":"Ubiquitin-Driven Proteostasis and Innate Immunity","description":"The cluster is dominated by ubiquitination-related processes (K48-, K6-linked ubiquitination, autoubiquitination, free ubiquitin chain polymerization) and cytoplasmic quality control via the ubiquitin-proteasome system, indicating a central role in proteostasis. The presence of terms connected to innate immune signaling (stimulatory C-type lectin receptor signaling; NF-kappaB activity) suggests a shared theme where ubiquitination modulates immune pathways. A peroxisomal import term appears peripheral to the main theme but does not override the core ubiquitin/proteostasis-immune link.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0016562","count":7},{"id":"GO:0010994","count":7},{"id":"GO:0002223","count":7},{"id":"GO:1903955","count":7},{"id":"GO:0051865","count":7}]},{"hash":"1600478576415847527","title":"Developmental angiogenesis and neural guidance","description":"The set of terms centers on cell migration during development, especially in the vascular/angiogenic context (angioblast migration, sprouting angiogenesis, lymph vessel development) and neural development (neural crest migration, retinal ganglion cell axon guidance, notochord formation). This suggests a coherent theme of migratory processes guiding vascular and neural patterning in development. Some terms related to T cell costimulation or MAPK signaling appear less central to the main theme, indicating some incidental associations, but the dominant signal is developmental migration and guidance. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031295","count":5},{"id":"GO:0050731","count":5},{"id":"GO:0035475","count":4},{"id":"GO:0001755","count":4},{"id":"GO:0031290","count":4}]},{"hash":"2076534055536344691","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006620","count":6},{"id":"GO:0051083","count":6}]},{"hash":"1375963098193292785","title":"DNA damage response and autophagy regulation","description":"The cluster shows a clear presence of autophagy and mitophagy-related terms (autophagy; negative regulation of mitophagy) alongside DNA damage signaling (regulation of response to DNA damage checkpoint signaling), suggesting a common theme of cellular stress response and organelle quality control. Additional terms related to xenobiotic response and metabolic processes support a broader stress-response module, though the core signal appears to center on autophagy/DNA damage interplay.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902153","count":2},{"id":"GO:0045730","count":2},{"id":"GO:1901525","count":2},{"id":"GO:0006003","count":2},{"id":"GO:0046835","count":2}]},{"hash":"1360306501477634136","title":"Ubiquitin-Proteasome Regulation of Mitosis","description":"The top GO terms are dominated by mitosis-related processes (cell division, mitotic cell cycle, APC- and SCF-dependent degradation, spindle checkpoint) and ubiquitin pathways (K11-linked ubiquitination, proteasomal degradation, ERAD). This suggests the cluster centers on how ubiquitin-proteasome\u2013mediated protein turnover controls mitotic progression, with some links to ER stress\u2013related quality control. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0031497","count":3},{"id":"GO:0070979","count":3},{"id":"GO:1902426","count":3},{"id":"GO:0070059","count":3}]},{"hash":"815621867691120968","title":"Muscle development and heart function","description":"The top GO terms cluster around skeletal muscle differentiation (myoblast fusion; negative regulation of skeletal muscle cell differentiation) and cardiac processes (cardiac muscle contraction; regulation of heart contraction; regulation of systemic arterial blood pressure), suggesting a focus on muscle development and cardiovascular regulation. Added terms like hypoxia response and positive regulation of mitochondrial calcium concentration point to metabolic and stress-responsive aspects in muscle tissue, while digestion and self proteolysis may reflect broader metabolic turnover. Together, these indicate a coherent theme of muscle physiology and heart function under regulatory and stress-related contexts.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:2001015","count":2},{"id":"GO:0007520","count":2},{"id":"GO:0097050","count":2},{"id":"GO:0060048","count":2}]},{"hash":"1691638702041426223","title":"Mitochondrial lipid remodeling and energy metabolism","description":"The set includes mitochondrial ATP synthesis (GO:0042775) and several lipid biosynthesis/remodeling processes (cardiolipin acyl-chain remodeling GO:0035965; phosphatidylcholine acyl-chain remodeling GO:0036151; phosphatidylcholine biosynthesis GO:0016024; ether lipid biosynthetic process GO:0008611; platelet activating factor biosynthetic process GO:0006663; negative regulation of phosphatidylcholine biosynthetic process GO:2001246). This points to a cohesive theme of mitochondria-associated lipid remodeling supporting energy production. Some terms (cerebellum morphogenesis, glandular epithelial cell maturation, T cell death regulation) are less directly tied but may reflect contextual tissue-specific roles of lipid metabolism. ","confidence":"High","size":7,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042775","count":4},{"id":"GO:0021587","count":4},{"id":"GO:0070236","count":4},{"id":"GO:0016024","count":4},{"id":"GO:0002071","count":4}]},{"hash":"290172790045868160","title":"Embryonic Development and Gene Expression Regulation","description":"The GO terms point to multiple embryonic tissues and processes (placenta, pancreas, cartilage, EMT in endocardial cushion formation) and to regulation of gene expression (transcriptional regulation, RNA splicing, ribosomal export). This pattern suggests a cluster of proteins coordinating developmental differentiation with core gene-expression machinery.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060806","count":2},{"id":"GO:1903026","count":2}]},{"hash":"1708593175633560915","title":"Placental development and mitochondrial apoptosis signaling","description":"The cluster shows strong representation of pregnancy-related terms (placental development, maternal processes in parturition) alongside mitochondrial outer membrane permeabilization, suggesting a link between placental development and mitochondrial-mediated apoptosis. The presence of an obsolete growth hormone term is less informative, so the core theme remains pregnancy-related development with mitochondrial signaling.","confidence":"Medium","size":7,"edges":10,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097345","count":2},{"id":"GO:0001893","count":2},{"id":"GO:0060137","count":2},{"id":"GO:1903547","count":2}]},{"hash":"252502678697220376","title":"Galactose and related carbohydrate metabolism","description":"This cluster shows strong enrichment for galactose- and other sugar-related processes: D-galacturonate metabolic process, galactose-driven glycolysis, galactitol metabolism, GDP-L-fucose salvage, and galactose-regulated transcription, with additional links to isoprenoid biosynthesis pathways (mevalonate/MEP). Together these terms point to a cohesive theme around galactose-centered carbohydrate metabolism and related sugar nucleotide production.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046396","count":2},{"id":"GO:0046835","count":2},{"id":"GO:0042352","count":2},{"id":"GO:0000435","count":2},{"id":"GO:0009088","count":2}]},{"hash":"595576719127425625","title":"Glycosylation in pollen germination and tube growth","description":"The top GO terms show a clear emphasis on glycosylation and glycan metabolism (N-glycan processing, N-linked glycosylation, protein sialylation, glycosphingolipid/ganglioside biosynthesis, sialic acid metabolism) alongside pollen development processes (pollen germination, pollen tube growth). This suggests a functional cluster where glycosylation-related pathways support pollen germination and tube elongation, possibly via modification of cell surface proteins and lipids. Some neural-development terms appear, but they seem peripheral to the dominant glycosylation-pollen theme.","confidence":"Medium","size":7,"edges":10,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009846","count":3},{"id":"GO:0006677","count":3},{"id":"GO:0006491","count":3},{"id":"GO:0071699","count":3},{"id":"GO:0021628","count":3}]},{"hash":"1030987827941012336","title":"Taste and Olfactory Learning Signaling","description":"The terms cluster around sensory perception (sweet taste detection, olfactory learning) and memory processes (long-term memory, conditioned taste aversion) with linked intracellular signaling (calcium regulation, cAMP signaling via forskolin), suggesting a cohesive theme of neural sensing and memory-related signaling rather than a single organ-specific function. A secondary, less central term is renal water homeostasis, but the predominant signal is taste/olfactory perception and learning.","confidence":"Medium","size":6,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070483","count":2},{"id":"GO:0001582","count":2},{"id":"GO:0003091","count":2},{"id":"GO:0007204","count":2},{"id":"GO:0035811","count":2}]},{"hash":"1354591940933187377","title":"GPCR-Mediated cAMP Signaling","description":"This cluster is dominated by GO terms tied to G protein-coupled receptor signaling, adenosine/adrenergic pathways, and cAMP production via adenylate cyclase (e.g., forskolin response, adenylate cyclase-activating pathways), with blue light signaling and transcription regulation downstream, suggesting a coherent GPCR-cAMP signaling theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0070483","count":6},{"id":"GO:1904322","count":6},{"id":"GO:0035556","count":6},{"id":"GO:0009785","count":6},{"id":"GO:0006171","count":6}]},{"hash":"2290633619188471428","title":"Sulfur-dependent tRNA modification and redox homeostasis","description":"The top GO terms cluster around sulfur metabolism and RNA modification: transsulfuration, tRNA wobble uridine thiolation, tRNA seleno-modification, URM1/urmylation, and Mo-molybdopterin cofactor biosynthesis\u2014all of which rely on sulfur transfer and redox chemistry. Additional terms like glycerol metabolism and mitotic M phase reflect broader cellular context, while spinal cord development hints at developmental aspects. Taken together, the cluster seems driven by sulfur-assisted RNA modification and related cofactor biosynthesis pathways.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":5},{"id":"GO:0006071","count":4},{"id":"GO:0019346","count":4},{"id":"GO:0032447","count":4},{"id":"GO:0006777","count":4}]},{"hash":"336268594257531751","title":"Developmental Transcription and Cell Cycle","description":"The top GO terms cluster around developmental processes (forebrain development, neural tube closure, skeletal system development, multicellular organism development) and transcription by RNA polymerase II, with accompanying mitotic cell cycle and DNA damage checkpoint signaling. This points to proteins involved in coordinating transcriptional programs during development with cell cycle control, rather than a single, narrow pathway, justifying a label centered on developmental transcription and cell cycle regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070816","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0031571","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0070059","count":2}]},{"hash":"30864915919120875","title":"Developmental morphogenesis and signaling","description":"The top GO terms point to morphogenesis (dendrite morphogenesis, outer ear morphogenesis) and proliferation in epithelial tissues (mammary gland), along with cellular signaling responses (prostaglandin E stimulus, phorbol ester response) and regulation of leukocyte chemotaxis. While some terms touch on DNA repair or metabolism (sterol import, cyclic nucleotide biosynthesis), the strongest signal is development-related morphogenesis paired with signaling responses, suggesting a cluster of proteins involved in tissue development and signal transduction.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":6},{"id":"GO:1990804","count":6},{"id":"GO:0033598","count":6},{"id":"GO:0002688","count":6},{"id":"GO:0071380","count":6}]},{"hash":"2244072524363168614","title":"Unknown","description":"The GO terms span a wide range of processes\u2014from neural and organ morphogenesis to DNA repair, signaling responses, metabolism, and immune-related functions\u2014without a clear, single shared function binding all proteins. This lack of a cohesive theme makes a specific, concise label inappropriate.","confidence":"","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":6},{"id":"GO:1990804","count":6},{"id":"GO:0033598","count":6},{"id":"GO:0002688","count":6},{"id":"GO:0071380","count":6}]},{"hash":"625059332113712660","title":"Ubiquitin-dependent protein modification and degradation","description":"This cluster centers on ubiquitination and ubiquitin-dependent degradation, with multiple GO terms for autoubiquitination, various ubiquitin linkages (K48, K63, K6), and proteolytic turnover, alongside regulation of JNK signaling and apoptosis. The recurring theme is ubiquitin-mediated modification and control of protein fate, spanning degradation and signaling pathways.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":5},{"id":"GO:0046328","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0070534","count":4},{"id":"GO:1901253","count":4}]},{"hash":"669110072020540501","title":"Differentiation and Signaling Regulation","description":"The top GO terms focus on differentiation processes (fat cell, myotube, and mammary gland epithelial cell proliferation) and signaling regulation (peptidyl-serine phosphorylation, PI3K/AKT signaling), with additional neural development hints (dendrite morphogenesis, LTP). This suggests a common theme of signaling-controlled differentiation, even though a single precise function isn\u2019t dominant.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0048240","count":3},{"id":"GO:0014902","count":3}]},{"hash":"475206568987322344","title":"Unknown","description":"The top GO terms span mitosis-related processes, circadian rhythm, multiple signaling pathways (Notch, JNK, JAK-STAT/interferon), synaptic functions, and symbiont-mediated immune suppression, with no single unifying theme. The cluster appears to involve disparate biological processes rather than a coherent function, so no specific, representative label can be confidently assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031536","count":2},{"id":"GO:0039563","count":2},{"id":"GO:0060266","count":2},{"id":"GO:0007219","count":2},{"id":"GO:0007623","count":2}]},{"hash":"926912189096652676","title":"GPCR Signaling and Neuronal Synaptic Regulation","description":"The top GO terms point to G protein-coupled receptor signaling and modulation of synaptic activity, including dopamine receptor signaling and regulation of excitatory postsynaptic potentials, complemented by related pathways like Wnt signalosome assembly and endosomal trafficking. While a few terms (e.g., TH1 immune response) are less directly tied to neural signaling, the dominant theme is GPCR-driven signal transduction that influences neuronal communication and intracellular trafficking, justifying a concise label focused on GPCR signaling in a neuronal/synaptic context.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0007186","count":3},{"id":"GO:0042088","count":3},{"id":"GO:1902499","count":2},{"id":"GO:0060161","count":2}]},{"hash":"2104352597279473797","title":"Insulin signaling and redox-regulated metabolism","description":"This cluster centers on metabolic regulation tied to insulin signaling (response to insulin, negative regulation of insulin secretion) and redox/homeostatic processes (redox homeostasis, oxidation-reduction). Glycerol-3-phosphate catabolism further supports a metabolic theme. Some terms appear as noise or broad housekeeping ( xenobiotic response, potassium transport, antigen biosynthesis, gastrulation), but the dominant signal is metabolism intertwined with insulin-related regulation and redox balance.","confidence":"Medium","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0046168","count":3},{"id":"GO:0014823","count":3}]},{"hash":"2083068039062311631","title":"C-type lectin and Fc receptor\u2013mediated innate immune signaling","description":"This cluster is dominated by GO terms tied to innate immune receptors and leukocyte activation (stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, leukocyte tethering/rolling) and responses to fungal origin, suggesting a shared function in pathogen recognition and immune cell signaling. A few developmental morphogenesis terms appear as outliers, but the core signal points to innate immune signaling pathways.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":3},{"id":"GO:0050901","count":3},{"id":"GO:0016032","count":2},{"id":"GO:0060355","count":2},{"id":"GO:0036303","count":2}]},{"hash":"179186911837612104","title":"Embryonic organogenesis and neural crest development","description":"The top GO terms point to broad embryonic morphogenesis across multiple organs (pituitary, pancreas, inner ear, pharyngeal system, gonads, uterus) and neural crest formation, suggesting the proteins share a developmental/differentiation role rather than a single specific pathway. The theme best captured is embryonic organogenesis with neural crest involvement.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0072107","count":3},{"id":"GO:0003309","count":3},{"id":"GO:0042472","count":3}]},{"hash":"521523524340589344","title":"Unknown","description":"The annotated GO terms span a wide range of biosynthetic and metabolic processes (lipid/steroid-related biosynthesis, vitamins/cofactors, antibiotics) plus developmental terms, with no obvious common pathway. Combined with zero edges among the proteins, there is no cohesive function tying these proteins together, so Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042619","count":4},{"id":"GO:0008209","count":3},{"id":"GO:0006666","count":3},{"id":"GO:0042376","count":3}]},{"hash":"483624882259919703","title":"Metabolism and Cofactor Biosynthesis","description":"This cluster includes proteins linked to diverse metabolic and cofactor-related processes: responses to sucrose, thiamine and menaquinone biosynthesis, sulfoquinovose catabolism, AMP salvage, and central carbon metabolism (malate/pyruvate) with NADP metabolism regulation. The shared theme is metabolism with cofactors rather than a single precise pathway, supporting a broad metabolic cluster label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009744","count":2},{"id":"GO:0009228","count":2},{"id":"GO:1902777","count":2},{"id":"GO:0044209","count":2},{"id":"GO:0009234","count":2}]},{"hash":"141126759689909027","title":"Actin Cytoskeleton Organization and Dynamics","description":"The cluster\u2019s top GO terms cluster around actin-related processes: actin filament bundle assembly, actin filament organization, and actomyosin structure organization, with links to filopodium assembly and cytoskeletal remodeling. A few terms (e.g., plant ovule morphogenesis, hepatocyte proliferation) appear as noise or misannotations, but the prevailing signal strongly supports an actin cytoskeleton focus.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:2000346","count":6},{"id":"GO:0046013","count":6},{"id":"GO:1903955","count":6},{"id":"GO:0051489","count":6},{"id":"GO:0048482","count":6}]},{"hash":"802053893353871181","title":"Cardiac cGMP signaling and calcium handling","description":"The cluster is dominated by GO terms centered on cGMP signaling and calcium dynamics, including negative regulation of guanylyl cyclase signaling, cellular response to cGMP, and regulation of calcium release from the sarcoplasmic reticulum, along with cardiac muscle contraction/relaxation terms. A smell/sensory term appears but does not define the main theme; overall, the proteins seem linked by cGMP-mediated signaling intersecting with cardiac calcium handling. ","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010754","count":5},{"id":"GO:0071321","count":5},{"id":"GO:0007608","count":5},{"id":"GO:0019933","count":4},{"id":"GO:0010880","count":3}]},{"hash":"2017215124292008996","title":"Gene Expression and RNA Metabolism","description":"This cluster centers on processes involved in gene expression and RNA fate, including DNA-templated transcription, mRNA catabolic processes, translation, and regulation of miRNA processing, suggesting a cohesive theme around RNA metabolism and protein synthesis; a couple of terms related to neuronal signaling and DNA repair regulation appear less directly connected but may reflect broader regulatory roles.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0032729","count":2},{"id":"GO:0006402","count":2},{"id":"GO:1905053","count":2},{"id":"GO:0000056","count":2}]},{"hash":"2301040913376171208","title":"Leukocyte chemotaxis and T cell regulation","description":"This cluster's terms are dominated by chemotaxis of several leukocyte types (macrophages, neutrophils, monocytes, eosinophils) and regulation of T cell activity, suggesting a theme of immune cell recruitment and T cell modulation. A glucose-response term is present but appears less central, so the core function is leukocyte trafficking and T cell signaling.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048246","count":3},{"id":"GO:2000562","count":3},{"id":"GO:0030593","count":3},{"id":"GO:0002548","count":3},{"id":"GO:0048245","count":3}]},{"hash":"600490054860309273","title":"Development and Stress Response","description":"This cluster's GO terms include neurogenesis, xenobiotic response, LPS response, complement activation, hypoxia, apoptosis, and tissue development, indicating broad stress- and development-related processes rather than a single cohesive pathway. The label reflects a mixed development- and stress-related function across the proteins.","confidence":"Medium","size":6,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0048672","count":3},{"id":"GO:0071222","count":3}]},{"hash":"1291468746097670695","title":"Growth and cell division machinery","description":"The cluster centers on cell proliferation and mitosis, with strong signals for cell cycle progression, mitotic spindle assembly, and ribosome biogenesis, complemented by TORC1-mediated growth signaling. ER-Golgi vesicle transport is consistent with increased biosynthetic demand during growth and division, tying together growth and proliferative processes.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0006890","count":5}]},{"hash":"2121793660613439941","title":"Unknown","description":"The GO terms are scattered across placental/maternal biology, endoderm differentiation, endocytosis, and mitochondria-related apoptosis, each with only one annotation and no interactions. This lack of a cohesive, common function makes a meaningful cluster label impossible.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":1},{"id":"GO:0097345","count":1},{"id":"GO:0001893","count":1},{"id":"GO:0060137","count":1},{"id":"GO:1903547","count":1}]},{"hash":"113819891345569030","title":"Developmental Signaling Pathways","description":"The Top Terms show emphasis on signaling cascades (ERK1/ERK2, Wnt, ephrin receptor) and immune development (T cell receptor signaling, beta selection) along with processes tied to morphogenesis and differentiation (dendrite morphogenesis, ossification). Together they indicate proteins involved in key signal transduction that governs development and cell fate across tissues, rather than a single pathway. This makes a cohesive label of Developmental Signaling Pathways appropriate.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0048013","count":6},{"id":"GO:0031532","count":6}]},{"hash":"1186889365429159375","title":"Neurite Outgrowth and Actin Remodeling","description":"The cluster is dominated by terms tied to neuron projection development and dynamic actin cytoskeleton processes, including actin nucleation, polymerization, filament assembly, severing, and various capping and Arp2/3\u2013mediated regulation. This pattern points to neurite extension and growth cone advancement driven by coordinated actin remodeling, with a minor note of vesicle trafficking that may assist growth. Overall, the core theme is actin-mediated neuronal projection growth.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":3},{"id":"GO:2000601","count":3},{"id":"GO:0051016","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0051694","count":3}]},{"hash":"961280073108603868","title":"Spliceosome-mediated mRNA splicing and translation initiation","description":"Multiple terms center on splicing and spliceosome function (mRNA cis splicing via spliceosome, splice site recognition, alternative splicing, processome assembly, and regulation of splicing). Additional terms point to translation initiation machinery (formation/assembly of the translation preinitiation complex, and eIF4F complex assembly). Together, the proteins likely participate in mRNA processing and preparation for translation.","confidence":"High","size":6,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":1},{"id":"GO:0034462","count":1},{"id":"GO:0006376","count":1},{"id":"GO:0097010","count":1},{"id":"GO:0006378","count":1}]},{"hash":"1688612130300673699","title":"Spliceosome-Mediated mRNA Processing and Translation Initiation","description":"The cluster is dominated by GO terms for mRNA splicing via the spliceosome (cis splicing, splice site recognition, alternative splicing, regulatory splicing), spliceosome assembly, and processes related to translation initiation complex formation and eIF4F assembly, indicating a cohesive function in RNA processing followed by initiation of translation.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":5},{"id":"GO:0034462","count":5},{"id":"GO:0006376","count":5},{"id":"GO:0097010","count":5},{"id":"GO:0006378","count":5}]},{"hash":"642089719330529971","title":"Brain membrane trafficking and synaptic plasticity","description":"The cluster shows neural development and synaptic regulation signals (substantia nigra development; long- and short-term synaptic plasticity; myelination) together with membrane organization/trafficking processes (transcytosis, raft polarization, eisosome assembly) and brain endothelial barrier features, suggesting a cohesive theme of brain development and synaptic function that depends on membrane trafficking.","confidence":"Medium","size":6,"edges":9,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045056","count":1},{"id":"GO:1902043","count":1},{"id":"GO:0035208","count":1},{"id":"GO:0001766","count":1},{"id":"GO:0048169","count":1}]},{"hash":"971751609727169017","title":"Germline Translational Regulation","description":"This cluster is dominated by translation-related GO terms (translation, cap-dependent translational initiation, negative regulation of translation) and includes meiotic/gametogenesis terms (meiotic chromosome condensation, male meiosis chromosome segregation, spermatocyte division) plus stem cell maintenance, suggesting a role in translational control during germ cell development. Some terms like viral process and fear response are less cohesive with the core theme, but the translational regulation signature in germ cells is the strongest signal.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0019827","count":2},{"id":"GO:0001662","count":2},{"id":"GO:0010507","count":2},{"id":"GO:0017148","count":2}]},{"hash":"1867368876107219544","title":"Embryonic organogenesis and neural crest development","description":"This cluster's GO terms cluster around development of multiple organs and neural tissues during embryogenesis\u2014inner ear, spinal cord/neural crest, pituitary, heart, lung, kidney, and mesodermal fate specification. The recurring theme is broad embryonic organ formation and neural development across diverse lineages, rather than a single molecular function. Therefore, a concise label capturing broad embryonic organ formation and neural crest is appropriate.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":5},{"id":"GO:0014029","count":4},{"id":"GO:0021920","count":4},{"id":"GO:0021983","count":4},{"id":"GO:0007501","count":4}]},{"hash":"1276726434695439403","title":"Ureteric bud development and ureter maturation","description":"Top GO terms cluster around ureteric bud formation and maturation, with BMP signaling involvement, suggesting a kidney/urinary tract development theme. While a few terms (e.g., thymic T cell selection, erythrocyte differentiation) appear, the dominant signals are ureter development-related, including ureteric bud formation, ureter maturation, and BMP-responsive regulation.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060676","count":6},{"id":"GO:2000703","count":6},{"id":"GO:0045648","count":6},{"id":"GO:1902499","count":6},{"id":"GO:0072107","count":6}]},{"hash":"2136818792402987879","title":"Neuronal signaling and trafficking regulation","description":"The top GO terms cluster around neural signaling and development, including GPCR signaling, Robo/Roundabout axon guidance, Wnt signalosome assembly, and regulation of postsynaptic potentials, along with processes involving vesicle trafficking (retrograde transport) and cytoskeletal remodeling (filopodium assembly) and ubiquitination. This pattern suggests a group of proteins coordinating neuronal communication, trafficking, and structural dynamics. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905279","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0035385","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0010738","count":2}]},{"hash":"1679153369831540869","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0019079","count":2},{"id":"GO:0009432","count":2},{"id":"GO:0071031","count":1}]},{"hash":"1788871247755593564","title":"Macrophage activation and oxidative burst","description":"This cluster is enriched for GO terms signaling macrophage-mediated antimicrobial activity, including phagocytosis, respiratory burst and ROS production (superoxide and hydrogen peroxide), macrophage chemotaxis, and innate immune cytokine responses (IL-6 and TNF). Together these terms indicate a macrophage activation program driving engulfment and oxidative killing of targets.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050766","count":2},{"id":"GO:0042554","count":1},{"id":"GO:0048246","count":1},{"id":"GO:1904845","count":1},{"id":"GO:0045730","count":1}]},{"hash":"1040169620611895045","title":"Neural Development and Sensory Perception","description":"Reasoning: The prominent GO terms\u2014retina development, sensory neuron axon guidance, and olfactory learning\u2014point toward neural development and sensory processing. Additional terms reflect general cellular and RNA-related processes that can occur in neurons, but the neural-themed terms dominate, suggesting this cluster centers on neural development and sensory function rather than a single housekeeping pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0097374","count":1},{"id":"GO:0017196","count":1},{"id":"GO:0006911","count":1}]},{"hash":"44594321494471242","title":"ER trafficking and mitosis proteins","description":"The top GO terms emphasize secretory pathway processes (ER to Golgi transport, ER membrane targeting, ERAD-related pathway) and general protein processing, while other terms point to cell division, centromeric chromatin assembly (CENP-A), microtubule severing, and actin capping. This combination suggests a cluster of proteins functioning in both ER-associated trafficking and mitotic/cytoskeletal regulation, justifying the label. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0061641","count":2}]},{"hash":"821142557852835916","title":"Ribosome Biogenesis and Translational Regulation","description":"This cluster is enriched for rRNA processing and 90S preribosome assembly, along with translation initiation and its regulation, indicating a focus on ribosome biogenesis and control of protein synthesis, including stress-responsive regulation. Some transcription-related terms appear, but the ribosome-focused terms are the primary signal.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006364","count":2},{"id":"GO:0032057","count":1},{"id":"GO:0031564","count":1},{"id":"GO:0006367","count":1}]},{"hash":"358674015529960222","title":"Nucleolar ribosome biogenesis and transcription","description":"The cluster shows GO terms centered on ribosome biogenesis, rRNA transcription, and nucleolar processes, including translation, ribosome biogenesis, nucleologenesis, nucleolar large rRNA transcription by RNA polymerase I, tRNA transcription by RNA polymerase III, RNA-templated transcription, and transcription by RNA polymerase II. This points to a nucleolus-associated theme of ribosome production and gene expression. A few terms (electron transport chain, sensory perception of sound) are less related and likely reflect annotation breadth rather than core function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0031048","count":1},{"id":"GO:0017126","count":1},{"id":"GO:0001172","count":1}]},{"hash":"2025971645570236505","title":"Macromolecular assembly and proteostasis","description":"This cluster centers on the formation and maintenance of macromolecular complexes and the cellular proteome. GO terms highlight assembly of spliceosomal and tubulin complexes, cytoskeletal organization, chaperone-assisted protein complex assembly, protein folding, and ubiquitin-proteasome\u2013mediated quality control, which together suggest a theme of macromolecular assembly and proteostasis. Additional terms for proton transport and vacuolar acidification point to organelle homeostasis that supports proper folding and assembly. Overall, the proteins likely participate in assembling large molecular machines and maintaining protein quality.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000245","count":1},{"id":"GO:0007021","count":1},{"id":"GO:0043622","count":1},{"id":"GO:0071629","count":1},{"id":"GO:0032968","count":1}]},{"hash":"980079899996877432","title":"Cardiac conduction and ion transport","description":"Top GO terms point to heart rate regulation by cardiac conduction, AV node action potential, and regulation of ventricular repolarization and atrial depolarization, plus potassium ion export and neuronal action potential. Although ossification and multicellular development terms appear, the core pattern centers on cardiac electrical activity and ion handling, justifying this label.","confidence":"High","size":6,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0060307","count":4},{"id":"GO:0060371","count":4},{"id":"GO:0086091","count":4}]},{"hash":"983966424628480632","title":"Embryonic Development and Organogenesis","description":"The cluster\u2019s top GO terms point to a broad suite of developmental and morphogenetic processes across multiple tissues (palatal roof development, placental and endocrine system development, cartilage morphogenesis, left-right patterning, EMT in heart development). The common thread is embryonic tissue formation and organogenesis, with transcription-related terms reflecting gene regulation during these processes. Confidence: High","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060806","count":4}]},{"hash":"15652820538699470","title":"Developmental adhesion and differentiation","description":"The top GO terms span diverse developmental processes (germinal center B cell differentiation, nephron and ureter development, radial glial differentiation, endothelial-related events) and adhesion activities (homophilic and calcium-dependent cell-cell adhesion). There is no single shared pathway linking all proteins; the common thread is development-related differentiation with adhesion, so this label captures the broad pattern without implying a specific function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002314","count":1},{"id":"GO:0097118","count":1},{"id":"GO:0060019","count":1},{"id":"GO:0072006","count":1},{"id":"GO:0045176","count":1}]},{"hash":"873076059198011966","title":"Cardiac conduction and rhythm regulation","description":"The top GO terms cluster around cardiac electrical activity: SA node action potential, regulation of ventricular and atrial membrane depolarization/repolarization, and regulation of heart rate through cardiac conduction. These collectively point to proteins involved in heart rhythm control and electrical signaling. Although there are some unrelated terms like ossification and innate immune response, the dominant pattern supports a cardiac electrical activity theme. Medium","confidence":"","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0045765","count":3}]},{"hash":"520044507329092543","title":"Lysosome Localization and Signaling Regulation","description":"The strongest and most specific GO term is protein localization to lysosome, suggesting core involvement in lysosomal trafficking. Additional terms point to broader regulatory roles in signaling (Notch, NF-kappaB) and junctional organization, indicating these proteins act as trafficking and signaling regulators rather than a single, uniform process. Confident that the lysosome localization aspect represents a central theme, with signaling modulation as a secondary aspect.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2000145","count":1},{"id":"GO:2000680","count":1},{"id":"GO:1904352","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0090528","count":1}]},{"hash":"85216716766269252","title":"ECM Remodeling and Basement Membrane Signaling","description":"The top GO terms cluster around extracellular matrix (ECM) organization and basement membrane development, including glomerular basement membrane formation, integrin-mediated signaling, calcium-independent cell-matrix adhesion, and negative regulation of ECM assembly, along with hyaluronan metabolism and metallopeptidase activity. These point to a cohesive theme of ECM remodeling, adhesion, and basement membrane dynamics, with supplementary hints of immune and developmental context (e.g., complement activation and T cell activation). This strongly supports a label focused on ECM/basement membrane biology.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032836","count":3},{"id":"GO:0007596","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0006956","count":2}]},{"hash":"2033952477010631922","title":"Developmental Signaling and Cytoskeletal Remodeling","description":"The cluster centers on signaling pathways (GTPase regulation, Wnt signaling, integrin signaling) and cytoskeletal dynamics (actin crosslink formation, dendritic spine morphogenesis, synaptic potentiation), with supporting developmental processes (heart development, endothelial barrier formation, brood size regulation). This points to a cohesive theme of signaling-driven cytoskeletal remodeling across development and neural plasticity, though the terms also span broader developmental contexts.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0060997","count":4},{"id":"GO:0051764","count":3}]},{"hash":"1297039924744605462","title":"Enteric nervous system signaling and gut motility","description":"This cluster is dominated by GO terms tied to the enteric nervous system and GI function, including peristalsis, development of the enteric nervous system, eating behavior, and dopaminergic synaptic transmission, plus GPCR signaling linked to cGMP and ERK cascade regulation. These together point to a coherent theme of neural control of gut motility and related gut behaviors, with a few ancillary stress-related terms that do not outweigh the core motif.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030432","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0048484","count":3},{"id":"GO:0046960","count":2}]},{"hash":"989848618735208724","title":"Mitochondrial apoptosis and membrane permeabilization","description":"The top GO terms are dominated by mitochondrial events related to apoptosis, including mitochondrial outer membrane permeabilization, and regulation of mitochondrial membrane permeability involved in apoptotic process, plus the generic apoptotic process term. This points to a mitochondria-mediated apoptosis cluster. A few outlier terms (DNA integration, cytochrome b6f complex assembly, placental development, epithelial migration) appear to be noise or cross-annotations rather than core functions of this cluster. Overall, the theme that ties the proteins together is involvement in mitochondrial regulation of apoptosis.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090143","count":1},{"id":"GO:0010190","count":1},{"id":"GO:0097345","count":1},{"id":"GO:0060137","count":1},{"id":"GO:0001893","count":1}]},{"hash":"1018535167368440247","title":"Membrane Solute Transporters","description":"The cluster is enriched for transmembrane transport GO terms spanning ions (sodium, potassium), nitrogen compounds (nitrite, nitrate), sugars (galactose, fucose), a sugar derivative (sialic acid), vitamin transport, and nitrate assimilation, indicating a group of diverse membrane transporter proteins responsible for uptake of various solutes.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0015707","count":2}]},{"hash":"1845806894187139360","title":"Developmental transcription and differentiation","description":"GO terms in this cluster center on DNA-templated transcription, with strong hints of trophoblast/placental differentiation and broader developmental processes (forebrain development, blood circulation). Supportive terms for cell cycle and DNA damage response suggest integration of transcriptional control with proliferation and stress signaling during development. Overall, the proteins appear to be involved in developmental regulation and lineage differentiation through transcriptional control, though the signals also touch on broader development contexts. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:1990086","count":1},{"id":"GO:0006884","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0008015","count":1}]},{"hash":"1651524548736741730","title":"Unknown","description":"The terms span xenobiotic response, olfactory perception, calcium regulation in muscle, monocyte differentiation, cardiac contraction and relaxation, and TGF-beta signaling, with no clear shared function among the five proteins. This lack of a cohesive theme suggests the cluster does not reflect a single, interpretable biological mechanism. Confidence: None","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":3},{"id":"GO:0007608","count":3},{"id":"GO:0010880","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0019934","count":2}]},{"hash":"1537032845545487231","title":"Embryonic and Organ Morphogenesis","description":"GO terms cluster around development and morphogenesis across multiple tissues (gonads, heart, eye, hindlimb, placenta, habenula, prostate), suggesting the proteins participate in embryonic morphogenesis and organ formation; a regulatory term is supportive context.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0003148","count":3},{"id":"GO:0048048","count":3},{"id":"GO:2000288","count":3}]},{"hash":"2132174088492387207","title":"Signaling and cell-cycle regulators","description":"The top GO terms point to regulation across multiple pathways (Notch signaling, JAK-STAT/interferon, JNK, circadian rhythm) and cell-cycle events (mitosis exit, spindle pole localization), plus neuronal synaptic regulation, indicating a cluster of proteins that broadly modulate signaling and cell-cycle processes rather than a single pathway. The presence of host-symbiont interaction terms further supports regulatory roles in complex signaling environments.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031536","count":1},{"id":"GO:0039563","count":1},{"id":"GO:0060266","count":1},{"id":"GO:0007219","count":1},{"id":"GO:0007623","count":1}]},{"hash":"702800799870948552","title":"Neuronal vesicle trafficking and dendrite morphogenesis","description":"The cluster is enriched for GO terms related to synaptic vesicle cycling (regulation of synaptic vesicle endocytosis, vesicle docking, vesicle size), intracellular transport, endosome-to-lysosome trafficking, and dendrite morphogenesis, with supporting microtubule involvement (tubulin complex assembly). This points to a coherent theme of vesicle trafficking in neurons and dendritic development. ","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":5},{"id":"GO:0007021","count":5},{"id":"GO:0006904","count":5},{"id":"GO:0048813","count":5},{"id":"GO:0010963","count":5}]},{"hash":"997572239598863902","title":"Immune signaling and adipocyte differentiation","description":"This cluster centers on innate immune responses to lipopolysaccharide and TLR9 signaling, with NF-kappaB pathway regulation, alongside processes related to fat cell differentiation and adipose tissue development. The co-occurrence of LPS response and adipogenesis terms suggests a theme of immune-inflammation intersecting with adipocyte biology, possibly reflecting metabolic-immune crosstalk in adipose tissue. The presence of leptin response and TH17 differentiation terms further supports an immune-metabolic context.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045598","count":2},{"id":"GO:0034162","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0043123","count":2}]},{"hash":"603523907614830574","title":"Ion transport and metal ion homeostasis","description":"GO terms are dominated by ion transport: calcium, potassium, and copper ion movement across membranes and into organelles (e.g., calcium transport from cytosol to ER; copper export; potassium export). This suggests a unifying theme of ion handling and metal ion homeostasis for the cluster, despite a few unrelated or obsolete terms. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051208","count":3},{"id":"GO:1901205","count":3},{"id":"GO:0097623","count":3},{"id":"GO:0033574","count":3},{"id":"GO:1903416","count":3}]},{"hash":"1631337107492351664","title":"Vesicle trafficking and endosome transport","description":"The cluster is dominated by terms related to vesicle dynamics: docking for exocytosis, endosome-to-lysosome transport, regulation of intracellular protein transport, and endocytosis. The inclusion of dendrite morphogenesis suggests a neuronal context where vesicle trafficking is essential, supporting a cohesive theme of vesicle transport and processing within cells.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000186","count":5},{"id":"GO:1900242","count":4},{"id":"GO:0006904","count":4},{"id":"GO:0048813","count":4},{"id":"GO:0010963","count":4}]},{"hash":"709185512825440756","title":"DNA replication and centrosome cycle","description":"This cluster centers on DNA replication and centrosome-related cell cycle processes (DNA replication, nuclear cell cycle regulation, and centrosome cycle), with some developmental terms (embryonic cranial skeleton morphogenesis, angiogenesis) suggesting roles in growth programs. The core signals are fairly strong around replication and centrosome dynamics, though some terms appear broader or developmental, reducing overall cohesion.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0035640","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0010571","count":3},{"id":"GO:0007098","count":3}]},{"hash":"566264169055241463","title":"Transmembrane Ion Transport","description":"Top GO terms indicate membrane transport across the cell membrane, highlighting magnesium, potassium, and proton transmembrane transport, along with glycine betaine transport. This points to a core function as ion and osmolyte transporters, with other metabolic terms or developmental annotations likely being secondary or incidental. So the cluster is best described by a shared function in transmembrane ion transport, hence the name. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903830","count":2},{"id":"GO:0019343","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0006177","count":2},{"id":"GO:0019346","count":2}]},{"hash":"828794137101597594","title":"DNA replication and growth signaling","description":"The top GO terms cluster around DNA replication and positive regulation of PI3K/AKT and ERK signaling, suggesting proteins involved in cell-cycle progression and mitogenic signaling. A secondary enrichment for toxic substance response is present but appears less central, so the main theme is replication-associated growth signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0051897","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0043552","count":2}]},{"hash":"1784513053489875373","title":"Unknown","description":"The top GO terms are very diverse, spanning DNA replication and cell-cycle regulation, chromatin silencing, apoptosis, plant signaling, and various developmental/neural processes (visual perception, heart and Schwann cell development, axonogenesis, excitatory postsynaptic potential). With no clear shared function or pathway and no edges connecting proteins, there is no cohesive theme tying this cluster together. Therefore Unknown with None confidence.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0030466","count":3},{"id":"GO:0043065","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1079005151582031035","title":"Metabolic Stress and Peroxisomal Fatty Acid Oxidation","description":"The terms cluster around energy metabolism under starvation, including peroxisomal/glyoxysomal fatty acid oxidation (glyoxysome organization; propionyl-CoA and ketone body catabolism; isoleucine catabolism) and related detoxification and apoptotic regulation, suggesting a theme of metabolic adaptation and redox balance. An outlier term related to kidney development is present but does not dictate the overall theme.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042594","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0032385","count":2},{"id":"GO:1902109","count":2},{"id":"GO:0010111","count":2}]},{"hash":"851058075029030861","title":"Synaptic vesicle trafficking and dendrite morphogenesis","description":"This cluster is enriched for neuronal vesicle cycling terms (regulation of synaptic vesicle endocytosis, vesicle docking in exocytosis, endosome-to-lysosome transport) and dendrite morphogenesis, with tubulin complex assembly supporting microtubule-based transport, suggesting coordinated synaptic vesicle trafficking and dendritic development in neurons.","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":5},{"id":"GO:0007021","count":5},{"id":"GO:0006904","count":5},{"id":"GO:0048813","count":5},{"id":"GO:0010963","count":5}]},{"hash":"2062139575274112643","title":"ER Proteostasis under Oxidative Stress","description":"This cluster centers on endoplasmic reticulum\u2013associated protein folding and repair, deglutathionylation, and redox/oxidative stress responses, indicating a coherent role in maintaining proteome integrity under oxidative conditions (some neuron-related and transcription terms may be less central).","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0010976","count":2},{"id":"GO:0034975","count":2},{"id":"GO:0006662","count":2}]},{"hash":"1487636645898935016","title":"Actin dynamics and sarcomere organization","description":"The set features multiple actin-related processes (filament fragmentation, debranching, cortical patch assembly) and Rho-mediated signaling, plus sarcomere organization and dendritic spine development, indicating a cohesive theme of actin cytoskeleton remodeling and organization across muscle and neuronal contexts.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030043","count":2},{"id":"GO:0007266","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0043538","count":2},{"id":"GO:0060999","count":2}]},{"hash":"1111514631163228729","title":"Cardiac development and calcium signaling","description":"These terms cluster around heart development and calcium handling. The strongest signals are left ventricular cardiac muscle tissue morphogenesis and outflow tract morphogenesis, supported by broader multicellular organism development and ossification terms. Calcium-release terms from the sarcoplasmic reticulum into the cytosol further align with cardiac muscle physiology. Some terms are more general (cell cycle, caffeine response), but the dominant theme points to cardiac development with associated calcium signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0097050","count":2},{"id":"GO:0003220","count":2},{"id":"GO:0043931","count":2}]},{"hash":"288046400494838590","title":"Blood-brain barrier and neural development","description":"The listed GO terms cluster around brain-related processes: substantia nigra development, neuronal synaptic plasticity, and myelination, along with endothelial barrier establishment and transcytosis. This suggests a theme of brain development and neural maintenance with vascular involvement, rather than a single enzymatic pathway.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1990592","count":1},{"id":"GO:0033146","count":1},{"id":"GO:0045056","count":1},{"id":"GO:1902043","count":1},{"id":"GO:0035208","count":1}]},{"hash":"1234586834943821316","title":"DNA Repair and Translation Regulation","description":"The GO terms show base-excision repair and DNA metabolic process, plus transcription elongation and gamma radiation response, indicating DNA damage response and repair. The presence of translation-related terms (translation, positive regulation of translation) suggests a coordinated link between genome maintenance and protein synthesis. This justifies a label that combines DNA repair with translation control.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006284","count":2},{"id":"GO:0097510","count":2},{"id":"GO:0090305","count":1},{"id":"GO:0006259","count":1}]},{"hash":"1435298969886991151","title":"Unknown","description":"The proteins in this cluster carry a very diverse set of GO terms, including mRNA processing, protein phosphorylation, Hippo and insulin signaling, ER-stress\u2013induced apoptosis, and nucleotide biosynthesis. There isn\u2019t a clear, shared function that coherently ties these terms together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0006468","count":2},{"id":"GO:0035329","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0008286","count":2}]},{"hash":"81396149222974453","title":"Cytoskeleton Remodeling and Cell Cycle","description":"The terms point to cytoskeletal dynamics (filopodium assembly, cell migration, bud growth, brush border assembly) coupled with cell cycle processes (DNA replication, regulation of cell cycle), suggesting a theme of morphogenesis and proliferation; other signaling or metabolic terms may be secondary features rather than core cluster defaults.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":2},{"id":"GO:0051489","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0050957","count":2},{"id":"GO:0070493","count":2}]},{"hash":"293441519437444022","title":"Chromatin-mediated transcriptional repression","description":"This cluster centers on GO terms related to negative regulation of RNA polymerase II transcription and regulation of transcription elongation, plus histone modifications (H2A ubiquitination, H3 acetylation). Although some terms are obsolete or biosynthesis-related noise, the dominant signal points to transcriptional control via chromatin modification, justifying a label focused on chromatin-based transcription repression.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070535","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0043966","count":2},{"id":"GO:1903257","count":1},{"id":"GO:0052707","count":1}]},{"hash":"5734524808470375","title":"Leukocyte adhesion and CLR signaling","description":"The top GO terms point to leukocyte tethering/rolling, stimulatory C-type lectin receptor signaling, and integrin-mediated signaling with cell-matrix adhesion, suggesting a theme of immune cell adhesion and signaling. However, several terms (viral process, germ-band extension, melanocyte differentiation) are unrelated to this core function, indicating heterogeneity and only partial representation of a single cohesive function. ","confidence":"Low","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050901","count":4},{"id":"GO:0002223","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0051089","count":2},{"id":"GO:0034241","count":2}]},{"hash":"1705196086966448775","title":"Transcription and preribosome assembly","description":"The terms cluster around transcription initiation and DNA-templated transcription, alongside ribosome biogenesis processes such as 90S preribosome assembly and ITS1 processing, plus RNA processing/splicing regulation. This points to a coordinated role in RNA synthesis and ribosome biogenesis, rather than a single narrow function.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031564","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0034463","count":2},{"id":"GO:0031047","count":2}]},{"hash":"439420641143864491","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034628","count":3},{"id":"GO:0015937","count":3},{"id":"GO:0019350","count":3},{"id":"GO:0097171","count":3},{"id":"GO:1990966","count":3}]},{"hash":"210577449783388020","title":"Unknown","description":"The top GO terms span many unrelated processes (amyloid precursor protein biosynthesis, transglutaminase cross-linking, hemoglobin metabolism, ER calcium regulation, deglycosylation, cell envelope organization, spleen development, inflammatory signaling, GPCR-PLC signaling, hair follicle morphogenesis), with no clear common function tying the proteins together. The protein set is small, with few interactions, making it unlikely to define a cohesive biological theme.","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042985","count":2},{"id":"GO:0018153","count":1},{"id":"GO:0020027","count":1},{"id":"GO:0032471","count":1},{"id":"GO:0006517","count":1}]},{"hash":"354451073737222055","title":"Gram-positive cell wall biosynthesis","description":"The top GO terms cluster around bacterial cell wall construction, including peptidoglycan biosynthesis and lipoteichoic acid biosynthetic processes, with an associated signal for cell shape regulation. This points to a shared function in Gram-positive cell wall synthesis and morphology, though some terms seem unrelated (e.g., certain xenobiotic/plant-related processes), likely reflecting annotation noise. Overall, the dominant theme is cell wall biosynthesis in Gram-positive bacteria.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008360","count":3},{"id":"GO:0033330","count":2},{"id":"GO:0006711","count":2},{"id":"GO:0006488","count":2},{"id":"GO:0009252","count":2}]},{"hash":"1973360859537090362","title":"Unknown","description":"The top GO terms cover a wide range of metabolic biosynthesis (poly-hydroxybutyrate, phylloquinone, tetrahydrobiopterin, antibiotic, steroid-related) and developmental processes (lung and retinal development). There is no single coherent function or pathway tying all terms together, so a specific label isn\u2019t evident.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0008209","count":3},{"id":"GO:0006666","count":3},{"id":"GO:0042376","count":3}]},{"hash":"1912905826305800341","title":"Retinoid and steroid metabolism in muscle differentiation","description":"Top GO terms indicate strong involvement in retinoic acid biosynthesis and retinol metabolic processes, paired with regulation of skeletal muscle fiber differentiation, and several steroid-related terms (androgen metabolic process, steroid catabolic process). This pattern suggests a cohesive cluster centered on metabolic signaling via retinoids and steroids that modulates muscle differentiation, with a few ancillary cellular processes such as iron homeostasis and mitochondrial-related protein handling contributing context. ","confidence":"Medium","size":5,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002138","count":2},{"id":"GO:0042572","count":2},{"id":"GO:0006879","count":2},{"id":"GO:0006465","count":2},{"id":"GO:1902809","count":2}]},{"hash":"2047476028081471435","title":"Cerebral neuron development and synaptic plasticity","description":"The top GO terms cluster around brain development and synaptic regulation (cerebral cortex development, neuron migration, regulation of synaptic plasticity), suggesting a theme of neuronal growth and synaptic function. While other terms touch on general growth, Golgi localization, insulin response, and mitochondrial apoptosis, the core pattern centers on neuronal development and synaptic control. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048167","count":4},{"id":"GO:0021987","count":4},{"id":"GO:0030307","count":4},{"id":"GO:0051683","count":4},{"id":"GO:0000079","count":4}]},{"hash":"23088298494038927","title":"Mixed signaling pathway regulators","description":"The set of GO terms spans diverse signaling routes, including immune (TLR2, NOD1), hormonal (luteinizing hormone), neurotransmitter (dopamine receptor) and receptor tyrosine kinase signaling. This suggests the cluster comprises proteins involved in broad signal transduction across systems rather than a single pathway, justifying a label of mixed signaling pathway regulators.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0051770","count":2},{"id":"GO:1902499","count":2},{"id":"GO:0060161","count":2},{"id":"GO:0042700","count":2}]},{"hash":"638403516113787290","title":"Spliceosome Assembly and Translation Initiation","description":"This cluster is driven by mRNA processing and spliceosome-related terms (positive regulation of mRNA splicing via spliceosome, regulatory ncRNA-mediated gene silencing, mRNA cis splicing via spliceosome, splice site recognition) and also by components of the translation initiation machinery (eukaryotic translation initiation factor 4F complex assembly, formation of translation preinitiation complex, protein targeting). The combination suggests a core of RNA processing with linked roles in initiating translation, consistent with a cohesive RNA processing/translation assembly theme.","confidence":"High","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006605","count":2},{"id":"GO:0000464","count":2}]},{"hash":"239904381792846849","title":"DNA damage response and cell cycle checkpoints","description":"The cluster centers on regulation of the cell cycle, mitotic spindle checkpoint signaling, and DNA damage\u2013related signaling, with associated telomere maintenance terms, suggesting a cohesive theme around genome stability and cell-cycle control. A couple of terms (oocyte development, lipoprotein catabolic process) seem less connected and may be noise.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":2},{"id":"GO:0048599","count":1},{"id":"GO:0030889","count":1},{"id":"GO:1904291","count":1},{"id":"GO:0042159","count":1}]},{"hash":"1193588970827178251","title":"Spliceosome and Translation Initiation Machinery","description":"This cluster is dominated by GO terms for mRNA splicing via the spliceosome (including splice site recognition, alternative splicing, and regulation of splicing) and for the formation/assembly of translation preinitiation complexes (including eIF4F and small-subunit processome-related steps). The co-occurrence of splicing and preinitiation complex terms suggests a coordinated role in RNA processing that links splicing to the initiation of translation, making \"Spliceosome and Translation Initiation Machinery\" a concise, representative label.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":5},{"id":"GO:0034462","count":5},{"id":"GO:0006376","count":5},{"id":"GO:0097010","count":5},{"id":"GO:0006378","count":5}]},{"hash":"1568411581163886677","title":"Ubiquitin-Mediated Antiviral Immune Regulation","description":"The cluster centers on ubiquitin-dependent protein regulation (aggresome assembly, autoubiquitination, proteolysis, histone ubiquitination) and host antiviral immune processes (RIG-I signaling, suppression of viral release, negative regulation of IL-1\u03b2, V(D)J recombination), suggesting a cohesive theme of ubiquitin-mediated control of antiviral responses and immune signaling.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0036353","count":5},{"id":"GO:0070842","count":5},{"id":"GO:0042787","count":5},{"id":"GO:1901253","count":4},{"id":"GO:0050713","count":4}]},{"hash":"1014277054826929771","title":"Ubiquitin-Driven Viral-Immune Modulation","description":"The GO terms cluster around ubiquitination processes (protein ubiquitination, polyubiquitination, autoubiquitination) and regulatory roles in viral interactions (viral entry, intracellular transport of viral material, suppression of viral release) as well as immune signaling (IL-1\u03b2 production, V(D)J recombination), with related apoptosis signals. This points to a shared theme of ubiquitin-mediated modulation of viral processes and immune responses.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0097345","count":2},{"id":"GO:0043931","count":2},{"id":"GO:1901253","count":2},{"id":"GO:0050713","count":2}]},{"hash":"413838815315284011","title":"Innate NF-kappaB/TNF signaling via ubiquitination","description":"The GO terms point strongly to innate immune responses and signaling through TNF and NF-kappaB, including activation of NF-kappaB-inducing kinase, I-kappaB phosphorylation, and K63-linked ubiquitination. The mention of protein localization to microtubules suggests a possible regulatory or trafficking role, but the core theme is NF-kappaB/TNF pathway regulation via ubiquitination in innate immunity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035372","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0045087","count":3},{"id":"GO:1903265","count":3}]},{"hash":"1797585666461410292","title":"Antiviral Defense and Interferon Response","description":"The top GO terms are dominated by antiviral-related processes: defense response to virus, cellular response to interferon-alpha, and negative regulation of defense response to virus by host, suggesting a cluster tied to innate immune/antiviral signaling. Some terms such as histone modification and steroid hormone receptor complex assembly appear as noise, but the antiviral/interferon terms appear most representative of the cluster\u2019s function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006463","count":4},{"id":"GO:0016570","count":4},{"id":"GO:0050689","count":4},{"id":"GO:0046661","count":4},{"id":"GO:0008277","count":4}]},{"hash":"142821428815242488","title":"Embryonic Development Signaling and Morphogenesis","description":"This cluster shows GO terms tied to embryonic axis determination, various organ morphogenesis processes (salivary gland development, lung morphogenesis, lactation), and signaling pathways (Wnt, RTK), plus neural development. The common thread appears to be developmental signaling coordinating tissue patterning and morphogenesis across different organs, rather than a single pathway or process. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007354","count":1},{"id":"GO:0007431","count":1},{"id":"GO:0033088","count":1},{"id":"GO:0070141","count":1},{"id":"GO:0090263","count":1}]},{"hash":"799826169839919238","title":"Unknown","description":"The GO terms are heterogeneous, including lysosome localization, septate junction assembly, development of microglia and retinal vasculature, and various signaling pathways, with several obsolete terms and no evident cohesive function tying the five proteins together.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000145","count":1},{"id":"GO:2000680","count":1},{"id":"GO:1904352","count":1},{"id":"GO:0043128","count":1},{"id":"GO:0090528","count":1}]},{"hash":"1123777558156644032","title":"Drosophila planar polarity and axon guidance","description":"The top GO terms cluster around heterophilic cell-cell adhesion, planar polarity establishment, and axon guidance events (R8 cell development, PCP pathway involvement). Several terms reference epithelial integrity and body hair orientation, which are consistent with morphogenetic processes guided by planar polarity cues. Overall, the set points to PCP-mediated morphogenesis and neural wiring rather than metabolism; thus the label reflects a cohesive function theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:0045463","count":2},{"id":"GO:0036514","count":2},{"id":"GO:1904938","count":2},{"id":"GO:0035160","count":2}]},{"hash":"21585395302928620","title":"Developmental processes and transcription regulation","description":"The top GO terms point to developmental biology (heart morphogenesis, animal organ development, spermatid nucleus differentiation) and cell division (spindle assembly), with additional emphasis on transcriptional control and chromatin modification (negative regulation of transcription by RNA Pol II and histone modification terms). Although some annotations are marked obsolete, the common theme centers on development coupled with transcription/chromatin regulation. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003007","count":2},{"id":"GO:1901726","count":1},{"id":"GO:0048513","count":1},{"id":"GO:2000864","count":1},{"id":"GO:0051569","count":1}]},{"hash":"715633489778030510","title":"RNA Methyltransferases","description":"The dominant GO terms point to RNA modification via methylation across multiple RNA types (mRNA cap methylation, guanine-N7 methylation, tRNA/rRNA methylation, and wobble uridine modification), with an additional example of peptidyl-glutamine methylation. This suggests the cluster comprises RNA methyltransferases/modification enzymes rather than a single pathway, even though a few other unrelated terms appear. Overall, the functional theme is clear and representative of RNA methylation machinery.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":4},{"id":"GO:0036265","count":4},{"id":"GO:0018364","count":3},{"id":"GO:0030488","count":3},{"id":"GO:0031167","count":3}]},{"hash":"191215759786494074","title":"Cell wall biosynthesis and morphogenesis","description":"This cluster shows enrichment for GO terms tied to the construction and organization of the cell wall, including peptidoglycan biosynthesis, lipopolysaccharide biosynthesis, fungal-type cell wall biogenesis, and cell wall mannoprotein biosynthesis, plus a general cell morphogenesis term. Together these suggest proteins involved in assembling or remodeling the cell wall across organisms, consistent with a wall biosynthesis/morphogenesis module. The presence of a term like \u201cresponse to antibiotic\u201d likely reflects stress-related associations with wall-targeting compounds rather than a separate function.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":2},{"id":"GO:0009089","count":1},{"id":"GO:0009272","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006048","count":1}]},{"hash":"643043349545258499","title":"Growth factor signaling and stress responses","description":"These proteins appear to participate in multiple signaling cascades triggered by growth factor receptors (IGF receptor, growth hormone receptor) and small GTPases, with downstream involvement in PI signaling, ER unfolded protein response, and extrinsic apoptotic pathways. While a few terms touch on development, the shared pattern is receptor- and GTPase-driven signaling intertwined with cellular stress responses, justifying a label focused on growth factor signaling and stress pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":3},{"id":"GO:0032481","count":3},{"id":"GO:0007264","count":3},{"id":"GO:1900103","count":3},{"id":"GO:0046856","count":3}]},{"hash":"1806539309838006636","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":3},{"id":"GO:0002635","count":3},{"id":"GO:0043029","count":3},{"id":"GO:0061470","count":3},{"id":"GO:0048535","count":3}]},{"hash":"1486304572225823397","title":"Neurogenesis and sensory neuron differentiation","description":"Most terms point to neural development and sensory differentiation (olfactory placode morphogenesis, ventricular zone neuroblast division, mechanoreceptor differentiation, neurogenesis, paranode axon localization). Some terms relate to broader development (lung-associated mesenchyme) or include immune/phagocytic pathways, which are less coherent with the main theme. Overall, the cluster seems best described by neural development and sensory differentiation.","confidence":"Medium","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071699","count":5},{"id":"GO:0060484","count":5},{"id":"GO:0042742","count":5},{"id":"GO:0038096","count":5},{"id":"GO:0086014","count":5}]},{"hash":"1110022134491992735","title":"Growth and survival signaling","description":"This cluster's top GO terms cluster around signaling pathways that govern cell growth, metabolism, and fate decisions, including T cell receptor signaling, insulin signaling regulation, TORC1 regulation, PI3K/AKT signaling, and the JNK cascade, with associated apoptotic and cell-cycle processes. The common thread is integration of growth signals with stress responses and survival versus death decisions, despite some terms related to mitosis and synapse assembly that may reflect broader cellular roles. Given the GO-term-driven grouping and lack of edges, the name emphasizes signaling impacting growth and survival.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":2},{"id":"GO:0046626","count":2},{"id":"GO:1904262","count":2},{"id":"GO:0007254","count":2},{"id":"GO:0051965","count":2}]},{"hash":"421631868379720317","title":"Steroid hormone metabolism and sex differentiation","description":"The GO terms for this cluster cluster around reproductive development and steroid hormone processing: maternal processes in parturition, sex differentiation, female genitalia development, and androgen/cholesterol metabolism, with related vitamin D pathways. A few terms about metal ion or nematode responses appear as peripheral signals, but the strongest, repeatedly represented themes are sex development and steroid/hormone metabolism, supporting this label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060137","count":3},{"id":"GO:0010164","count":3},{"id":"GO:0030540","count":3},{"id":"GO:0042369","count":3},{"id":"GO:0008209","count":3}]},{"hash":"948238035388952645","title":"Embryonic placental and endocrine organogenesis","description":"The cluster shows strong signals for placental development (trophoblast giant cell differentiation, placenta development) and endocrine tissue development (endocrine system development, pancreatic beta cell development), plus an EMT event in heart-related formation. These together point to embryonic organogenesis focusing on placenta and endocrine tissues, with supporting general developmental processes like transcription regulation and RNA processing. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060806","count":4},{"id":"GO:1903026","count":4}]},{"hash":"501996201717847604","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0007014","count":3},{"id":"GO:1903762","count":3},{"id":"GO:0060816","count":3},{"id":"GO:0002635","count":3}]},{"hash":"152616217384511866","title":"Unknown","description":"Top GO terms are highly heterogeneous, including phagocytosis recognition, olfactory placode morphogenesis, lung mesenchyme development, neuroblast division, mechanoreceptor differentiation, axon paranode localization, salivary gland boundary specification, and membrane transport. With no edges or triangles, there is no shared core function linking these proteins, so there is no cohesive theme to assign a specific label. The cluster is therefore Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":2},{"id":"GO:0071699","count":2},{"id":"GO:0060484","count":2},{"id":"GO:0050925","count":2},{"id":"GO:0021847","count":2}]},{"hash":"2003300771935236790","title":"Epithelial Adhesion and Junction Assembly","description":"The most represented terms relate to cell adhesion to extracellular matrix and to other cells, as well as assembly of cell-substrate junctions, which are hallmarks of epithelial tissue organization. Additional terms about skin development and endodermal differentiation support a tissue- and morphogenesis-related theme. Some terms (memory; symbiont entry into host cell) are less clearly linked and may reflect annotations beyond the core adhesion function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0032516","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0007613","count":2}]},{"hash":"1763180690379981276","title":"ERAD and ubiquitin-proteasome degradation","description":"The top GO terms cluster around ubiquitin-dependent proteolysis (ERAD, SCF-dependent proteasomal degradation) and polyubiquitination, with autophagy and ER-to-Golgi transport also represented, suggesting a group of proteins involved in protein quality control and turnover via ubiquitin-proteasome and related pathways. Some peripheral terms (e.g., skeletal development) may reflect broader annotations rather than core functions, and the lack of interactions among members indicates shared functional themes rather than a single complex. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1811306165313162115","title":"Cell signaling and intracellular trafficking","description":"This cluster shows representation across multiple signaling pathways (cAMP, Wnt, integrin, TGF-beta) and trafficking/localization processes (Golgi localization, peroxisome matrix import), suggesting a broad role in signaling coupled with protein trafficking rather than a single specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019933","count":2},{"id":"GO:0090557","count":2},{"id":"GO:0060378","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0007229","count":2}]},{"hash":"1308337903998200594","title":"Proteoglycan and GAG Biosynthesis","description":"This cluster is dominated by terms tied to proteoglycan and glycosaminoglycan (GAG) metabolism, including keratan sulfate and heparin proteoglycan biosynthetic processes and N-acetylglucosamine metabolism, as well as sulfate assimilation. These points suggest a coherent theme of extracellular matrix components (proteoglycans/GAGs) biosynthesis and modification, with developmental ECM roles reflected by embryonic neurocranium morphogenesis. Some broader metabolic terms (e.g., xenobiotic metabolism) are more general context but do not override the central GAG/proteoglycan signal. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002002","count":3},{"id":"GO:0006711","count":3},{"id":"GO:0018146","count":3},{"id":"GO:0006044","count":3},{"id":"GO:0030205","count":3}]},{"hash":"177444007684444233","title":"Mitochondrial Transporters and Vesicle Trafficking","description":"This cluster combines multiple mitochondrial metabolite transport processes (alpha-ketoglutarate, ornithine, glycine, iron import, ATP transport, malate-aspartate shuttle) with vesicle trafficking activities (intracellular transport, clathrin-mediated endocytosis, synaptic vesicle coating), suggesting a theme of coordinated mitochondrial metabolism and vesicle dynamics relevant to glucose-stimulated insulin signaling.","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":3},{"id":"GO:0006886","count":2},{"id":"GO:0016183","count":2},{"id":"GO:0072583","count":2},{"id":"GO:0048250","count":2}]},{"hash":"1061631553836525314","title":"Unknown","description":"The GO terms are highly diverse (telomere maintenance, chromosome localization, cardiac depolarization, NF-kappaB sequestration, epithelial polarity, actin assembly, fat cell differentiation, NOD2 signaling). There is no single dominant function linking the five proteins, so a coherent, specific label cannot be derived.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":2},{"id":"GO:0070198","count":2},{"id":"GO:0086070","count":2},{"id":"GO:0007253","count":2},{"id":"GO:1900827","count":2}]},{"hash":"121763429178464764","title":"Arabinogalactan Protein Metabolism","description":"The terms cluster around arabinogalactan proteins and related glycosylation/biosynthesis (AGP metabolic process, arabinogalactan biosynthesis, hydroxyproline O-glycosylation, Lewis A epitope biosynthesis) with linked plant development processes such as root hair formation and seed coat mucilage, suggesting a cohesive theme of plant cell wall glycoprotein production. Some insect-related terms appear less connected, but the AGP/glycosylation signals dominate.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0030311","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0048354","count":3}]},{"hash":"500820875479871915","title":"Antibacterial defense and peptidoglycan breakdown","description":"The prominent GO terms show defense response to bacterium and peptidoglycan/cell wall catabolic processes, pointing to proteins involved in antibacterial defense and degradation of bacterial cell wall components. Less central terms (e.g., viral release, cytolysis) may reflect broader host-pathogen interactions or annotation noise. Overall, the core theme is antibacterial response and cell wall breakdown. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":2},{"id":"GO:0051482","count":2},{"id":"GO:0016998","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0019076","count":2}]},{"hash":"1041660333242559910","title":"Ubiquitination and autophagy in vesicle trafficking","description":"These five proteins show GO terms clustered around protein ubiquitination (polyubiquitination, autoubiquitination, K6-linked ubiquitination), autophagy, and vesicle transport (anterograde synaptic vesicle transport). Although a few terms relate to immune or bone-resorption processes, the dominant theme is ubiquitin-mediated modification and degradation pathways that regulate intracellular trafficking and vesicle dynamics, justifying a label centered on ubiquitination and autophagy in vesicle traffic.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901253","count":1},{"id":"GO:0045453","count":1},{"id":"GO:0033151","count":1},{"id":"GO:0051865","count":1},{"id":"GO:0031666","count":1}]},{"hash":"1624637326391101669","title":"Sarcomere organization and cardiac signaling","description":"Dominant signals are sarcomere organization (and its positive regulation) along with heart rate regulation by epinephrine and GPCR signaling linked to cGMP, which together point to a cluster of proteins involved in muscle structural assembly and cardiovascular signaling. Nervous system development and thermosensory terms appear as secondary or cross-annotation, and the lack of edges suggests these proteins collectively emphasize the muscle/cardiac function theme. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0060298","count":4},{"id":"GO:0040040","count":4},{"id":"GO:0003065","count":4}]},{"hash":"1091033066033362225","title":"Unknown","description":"The top GO terms are highly diverse, spanning muscle fiber transition and regulation, DNA replication/repair, innate immune response, Schwann cell development, cadmium response, meiotic cell cycle, and synaptic signaling, with no single coherent biological theme connecting all terms. This makes it impossible to assign a concise, representative label for the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014883","count":3},{"id":"GO:0045988","count":3},{"id":"GO:0042220","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006281","count":2}]},{"hash":"504702951376935794","title":"Cell Cycle Regulation and Wnt Signaling","description":"The top GO terms cluster around mitotic cell cycles (syncytial blastoderm mitotic cell cycle, re-entry into mitotic cell cycle), and regulation of cyclin-dependent kinase activity, along with the canonical Wnt signaling pathway. This suggests a core theme of coordinating cell division with signaling during development, despite some tissue-specific terms that may reflect broader annotations. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035186","count":1},{"id":"GO:0007595","count":1},{"id":"GO:0033598","count":1},{"id":"GO:0033327","count":1},{"id":"GO:0000122","count":1}]},{"hash":"260722745331937072","title":"Ubiquitin-Mediated Immune Signaling","description":"The top terms cluster around ubiquitination (protein ubiquitination, autoubiquitination, K6-linked ubiquitination) and immune signaling pathways (NF-kappaB activation, JNK cascade, TNF signaling), with a note on V(D)J recombination and histone turnover, suggesting a function in ubiquitin-dependent regulation of immune signaling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903762","count":3},{"id":"GO:0016567","count":3},{"id":"GO:1901253","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0033151","count":3}]},{"hash":"418925686919820329","title":"Membrane Transport and Vesicle Trafficking","description":"The top GO terms point to diverse membrane-transport activities, including potassium ion transmembrane transport, membrane hyperpolarization, phospholipid translocation, various ion and peptide import/export into organelles, and vesicle docking in exocytosis. While a couple terms (stem cell proliferation, sperm capacitation) are less clearly tied to transport, the dominant signal is membrane movement of ions and molecules and vesicle trafficking, which justifies a label focused on membrane transport.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0060081","count":2},{"id":"GO:0072089","count":1},{"id":"GO:0006904","count":1},{"id":"GO:0036249","count":1}]},{"hash":"135672328160036841","title":"Ion Transport Across Membranes","description":"This cluster centers on transport of ions and small molecules across membranes, highlighted by calcium, potassium, and copper ion export, plus polyamine transmembrane transport and calcium movement between cytosol and ER. A few terms are obsolete or related to hormone signaling or metabolism, but the dominant signal is membrane transport of ions/small molecules.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051208","count":4},{"id":"GO:1901205","count":4},{"id":"GO:0097623","count":4},{"id":"GO:0033574","count":4},{"id":"GO:1903416","count":4}]},{"hash":"1781989324197623512","title":"Calcium, potassium, and metal ion transport","description":"The cluster is driven by multiple GO terms describing transport of calcium, potassium, and copper ions across membranes (including calcium sequestration and calcium transport to the ER, as well as copper and potassium ion export). This points to a central theme of membrane ion transport and ionic homeostasis, with a few peripheral terms related to hormonal responses or metabolism that do not define the core function.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051208","count":3},{"id":"GO:1901205","count":3},{"id":"GO:0097623","count":3},{"id":"GO:0033574","count":3},{"id":"GO:1903416","count":3}]},{"hash":"1928734176151251950","title":"Plant cell wall modification and plasmodesmata organization","description":"The strongest signals are GO:0009831 (plant-type cell wall modification) and GO:0009663 (plasmodesma organization) along with GO:2001009 (regulation of plant-type cell wall cellulose biosynthetic process), pointing to a coherent function in plant cell wall dynamics and intercellular transport through plasmodesmata.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009831","count":2},{"id":"GO:0009663","count":2},{"id":"GO:2001009","count":2},{"id":"GO:1903830","count":1},{"id":"GO:0019343","count":1}]},{"hash":"1134794942413284140","title":"Cytokinesis and Microtubule Dynamics","description":"This cluster centers on cytokinesis and cytoskeletal organization, with GO terms like FtsZ-dependent cytokinesis, microtubule nucleation, cell septum assembly, mitotic spindle pole body duplication, and general cell division, indicating a shared role in division machinery and microtubule dynamics across kingdoms. Additional terms referencing neuron migration and mechanosensory detection likely reflect broader cytoskeletal roles in motility and sensing, reinforcing the central theme of cytoskeletal regulation during division and movement.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043093","count":4},{"id":"GO:0007020","count":4},{"id":"GO:0090529","count":4},{"id":"GO:0051258","count":4},{"id":"GO:0001764","count":4}]},{"hash":"2216332655443370813","title":"Neural development and axon guidance","description":"Based on the strongest representation of nervous system development terms, including nervous system development, corpus callosum development, dendritic spine morphogenesis, and axon guidance-related terms, the cluster appears to group proteins involved in neural development and axon pathfinding. A few outlier terms related to immune clearance and ovulation are present but less represented, suggesting they are incidental. Therefore, the label captures the core function of the cluster.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0048320","count":3},{"id":"GO:0022038","count":3},{"id":"GO:0060997","count":3},{"id":"GO:0043277","count":3}]},{"hash":"66536990578530765","title":"Neural signaling and synaptic plasticity","description":"This cluster shows a group of GO terms centered on neural signaling and memory-related processes: long-term potentiation, regulation of presynaptic calcium, long-term memory, and retina development, all pointing to neural function and synaptic plasticity. Some outlier terms related to muscle contraction or development exist, but the core theme is neuronal communication and memory formation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042554","count":2},{"id":"GO:0072205","count":2},{"id":"GO:0086004","count":2},{"id":"GO:1900271","count":2},{"id":"GO:0035774","count":2}]},{"hash":"855299614520539099","title":"Developmental Morphogenesis and Signaling","description":"The proteins cluster around morphogenesis-related terms (dendrite morphogenesis, outer ear morphogenesis, mammary gland epithelial cell proliferation) and signaling or stimulus-response terms (cellular response to prostaglandin E, phorbol ester response, cyclic nucleotide biosynthetic process), suggesting a shared theme of developmental processes and cellular signaling, with a few outliers (DNA repair, sterol import) that may reflect broader annotation.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":4},{"id":"GO:1990804","count":4},{"id":"GO:0033598","count":4},{"id":"GO:0002688","count":4},{"id":"GO:0071380","count":4}]},{"hash":"1515967207620227595","title":"Neuronal development and axonogenesis","description":"This cluster is rich in neuronal development terms, including neurogenesis, axonogenesis, and regulation of axon extension, plus axon paranode localization and receptor tyrosine kinase signaling. The involvement of BMP and PI3K/AKT pathways supports a coordinated signaling role in neuronal growth and axon formation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048692","count":3},{"id":"GO:1902997","count":3},{"id":"GO:0050772","count":3},{"id":"GO:0050925","count":3},{"id":"GO:0007169","count":3}]},{"hash":"493846850543913245","title":"ER Protein Folding and Retention","description":"The terms cluster around endoplasmic reticulum\u2013associated processes: folding of proteins in the ER, retention of proteins within the ER lumen, protein repair, and redox-related modifications (deglutathionylation), with a note of secretion, pointing to ER quality control and trafficking. Some terms are obsolete, but the core theme remains ER protein handling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043388","count":2},{"id":"GO:0034975","count":1},{"id":"GO:0006662","count":1},{"id":"GO:0000187","count":1},{"id":"GO:0045454","count":1}]},{"hash":"2093895561978586581","title":"Ubiquitination and Related PTMs","description":"This cluster is dominated by post-translational modification (PTM) processes, especially ubiquitin-related events: deubiquitination, autoubiquitination, and sumoylation, with additional signals for deglycosylation and mitophagy. These terms point to a shared theme of protein modification and turnover, including quality-control pathways like mitophagy that intersect with ubiquitin/SUMO systems. Therefore, a concise label focusing on ubiquitination and related PTMs best captures the cluster\u2019s functional theme.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":2},{"id":"GO:1902236","count":1},{"id":"GO:0045648","count":1},{"id":"GO:0035186","count":1},{"id":"GO:0060334","count":1}]},{"hash":"257985966438555833","title":"Mitochondrial quality control and ubiquitin/SUMO regulation","description":"This cluster centers on mitochondria-related quality control (mitophagy, mitochondrial fusion) and regulation of protein modification pathways (ubiquitination, sumoylation, deglycosylation). It also includes modulation of innate immune and stress signaling (TNF, TLR3) and ER stress\u2013induced apoptotic pathways, suggesting a cohesive theme where post-translational regulation maintains mitochondrial integrity and tunes stress responses.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033132","count":3},{"id":"GO:0051865","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0034140","count":3},{"id":"GO:1902236","count":2}]},{"hash":"697601158945196788","title":"Proteostasis and mitochondrial quality control","description":"These proteins cluster around protein modification and turnover (sumoylation, ubiquitination), regulation of degradation (proteasome, autoubiquitination, deglycosylation), and organelle quality control pathways (mitophagy, aggresome formation, mitochondrial fusion), pointing to a shared role in maintaining proteome integrity and mitochondrial function under stress.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":3},{"id":"GO:1901799","count":3},{"id":"GO:1902236","count":2},{"id":"GO:0045648","count":2},{"id":"GO:0033132","count":2}]},{"hash":"2001823302270392197","title":"Neural development and synaptic assembly","description":"The top GO terms point to neural development (otic vesicle morphogenesis, third ventricle development), and synapse assembly, with additional signals of neuronal stress responses and ubiquitin-proteasome\u2013mediated protein turnover. This suggests a cluster centered on neural development and the regulation of proteins during neuronal differentiation and synaptic organization.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071600","count":2},{"id":"GO:0000083","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0007057","count":2}]},{"hash":"644698996177748691","title":"Energy metabolism and organ development","description":"The GO terms cluster around metabolic pathways (short-chain fatty acid metabolism, ketone body catabolic processes, and starvation response) alongside tissue development signals (heart, brain, and adipose development) and insulin secretion regulation, suggesting a theme where energy metabolism is linked to developmental/regulatory processes in multiple tissues.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":1},{"id":"GO:0060612","count":1},{"id":"GO:0046459","count":1},{"id":"GO:0014823","count":1},{"id":"GO:0042594","count":1}]},{"hash":"391155875881105421","title":"Visual system development and angiogenesis","description":"The cluster's top terms are dominated by angiogenesis and visual perception, pointing to genes involved in eye/retina development and associated vascularization. The exocytosis regulation term suggests neuronal signaling, aligning with retinal neurons; while other terms indicate broader developmental processes, the strongest signal centers on visual system development and vascularization.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0045921","count":2},{"id":"GO:0014029","count":1},{"id":"GO:0071456","count":1}]},{"hash":"1427424492005417044","title":"Xenobiotic degradation and oxidative stress response","description":"The top GO terms cluster around xenobiotic metabolism and pollutant catabolism (alkanesulfonate and 4-nitrophenol catabolic processes) alongside oxidative stress responses (removal of superoxide radicals, response to oxidative stress) and general xenobiotic metabolic processes, suggesting a group of proteins involved in detoxification and environmental pollutant degradation. A few terms (potassium ion transport, aging) seem incidental to the main theme but do not override the shared detoxification signal.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":2},{"id":"GO:0006979","count":1},{"id":"GO:0009970","count":1},{"id":"GO:0019430","count":1},{"id":"GO:0046196","count":1}]},{"hash":"1689907583135874671","title":"Ubiquitin-Dependent Degradation and Autophagy","description":"The terms are dominated by ubiquitination-related processes (polyubiquitination, autoubiquitination, ubiquitin-dependent proteolysis) and autophagy, with additional antiviral host-response terms (suppression of viral release, transport of viral material). This suggests a cohesive cluster centered on ubiquitin-driven protein degradation and autophagic pathways, potentially in antiviral contexts.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:1901253","count":3},{"id":"GO:0033151","count":3},{"id":"GO:0051865","count":3},{"id":"GO:1902187","count":3}]},{"hash":"2251420131883681678","title":"Leukocyte adhesion and complement activation","description":"This cluster is dominated by GO terms related to leukocyte capture on the endothelium (leukocyte tethering or rolling) and complement activation via the lectin pathway, with supporting signals for cell adhesion molecule production and heterophilic cell\u2013cell adhesion. While there are a few developmental terms (coronary artery morphogenesis, endodermal differentiation) these do not outweigh the adhesion/immune pattern, suggesting an immune-vascular adhesion theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050901","count":4},{"id":"GO:0001867","count":3},{"id":"GO:0060355","count":2},{"id":"GO:0051873","count":2},{"id":"GO:0001502","count":2}]},{"hash":"1256957543352527710","title":"Transcriptional regulation of skeletal development","description":"The terms point to transcriptional control (DNA-templated transcription) paired with skeletal morphogenesis, suggesting proteins that regulate gene expression during skeletal development. Most other GO terms are either obsolete or tangential (ion export, hormone response) and there are no interactions among the four proteins, indicating a modest, development-focused theme rather than a broad, shared function across diverse processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0051208","count":1},{"id":"GO:1901205","count":1},{"id":"GO:0097623","count":1}]},{"hash":"1665346654441122138","title":"Lipid and branched-chain amino acid metabolism","description":"The terms cluster around energy metabolism, especially lipid catabolism and transport (fatty acid beta-oxidation, fatty-acyl-CoA biosynthesis, carnitine biosynthesis) along with branched-chain amino acid (valine, leucine) catabolism, and to a lesser extent glycogen biosynthesis. These together suggest enzymes involved in energy production and metabolic processing, rather than a single specialized function. Some developmental terms appear, but the dominant signal is metabolic pathways. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033539","count":1},{"id":"GO:0009791","count":1},{"id":"GO:0006574","count":1},{"id":"GO:0005978","count":1},{"id":"GO:0006552","count":1}]},{"hash":"260076064361995430","title":"Lysosome-linked lipid metabolism and detoxification","description":"The top GO terms cluster around lysosomal enzyme secretion, lipid-related catabolic steps (triglyceride and phospholipid metabolism), and detoxification, with a few more divergent catabolic pathways present. This suggests a broad theme of metabolic processing and detox capability rather than a single precise function, hence a label focusing on lysosome-associated lipid metabolism and detoxification. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033299","count":2},{"id":"GO:0046839","count":1},{"id":"GO:0042952","count":1},{"id":"GO:0009086","count":1},{"id":"GO:0006212","count":1}]},{"hash":"495969824685749767","title":"Unknown","description":"The proteins' top GO terms span immune/stress responses (response to lipopolysaccharide, response to copper ion, response to antineoplastic agent) and a variety of metabolic processes (galactose and sugar alcohol catabolism, furaldehyde metabolism, Ehrlich pathway, fatty acid and lignin biosynthesis). There isn't a single coherent function or pathway that ties these terms together, so a concise, specific label cannot be confidently assigned.","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0045777","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0033498","count":4},{"id":"GO:0000947","count":4},{"id":"GO:0097327","count":4}]},{"hash":"1929968905264040814","title":"Neural crest and nervous system development","description":"The terms prominently feature neural crest formation, parasympathetic nervous system development, and neuronal specification, indicating a developmental program centered on neural crest\u2013derived and peripheral nervous system formation. Additional terms reference broader organogenesis (pituitary gland, semicircular canal, ureteric bud), suggesting the cluster captures general developmental pathways that include nervous system patterning as a core theme.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0014029","count":4},{"id":"GO:0021920","count":4},{"id":"GO:0021983","count":4},{"id":"GO:0048486","count":4},{"id":"GO:0003285","count":4}]},{"hash":"1012025898342116512","title":"Leukocyte chemotaxis and differentiation","description":"The cluster\u2019s GO terms are dominated by immune cell movement and maturation, including monocyte differentiation, dendritic cell chemotaxis, and neutrophil chemotaxis, along with related migration and adhesion-related processes. Despite some diversity and a few deprecated terms, the strongest signal points to leukocyte recruitment and maturation functions, suggesting these proteins contribute to immune cell trafficking and differentiation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0030224","count":1},{"id":"GO:1900026","count":1},{"id":"GO:0035042","count":1},{"id":"GO:0014065","count":1}]},{"hash":"2149349208837920183","title":"Bacterial LPS core and sugar-nucleotide biosynthesis","description":"The top GO terms are dominated by lipopolysaccharide biosynthetic processes and specific sugar-nucleotide pathways (dTDP-rhamnose and ADP-L-glycero-beta-D-manno-heptose), strongly suggesting involvement in LPS core assembly and related sugar biosynthesis in bacteria. While there are some unrelated terms (sporulation, transcription regulation), the cohesive theme is envelope biogenesis and sugar-nucleotide production. High","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0099132","count":2},{"id":"GO:1902321","count":1}]},{"hash":"522932800657590052","title":"Actin Cytoskeleton Assembly and Organelle Inheritance","description":"This cluster is enriched for Arp2/3 complex\u2013mediated actin nucleation, cortical patch assembly, and sarcomere organization, pointing to actin cytoskeleton assembly. It also includes vacuole and mitochondrion inheritance, both actin\u2011dependent processes in fungi, and ascospore wall assembly, linking actin dynamics to sporulation. Thus the common theme is actin cytoskeleton organization with organelle inheritance in fungal cells.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034314","count":4},{"id":"GO:0030476","count":4},{"id":"GO:0051592","count":4},{"id":"GO:0000011","count":4},{"id":"GO:0045214","count":4}]},{"hash":"1696298529562944278","title":"Wnt-Regulated Cartilage and Vascular Development","description":"These terms cluster around Wnt signaling regulation and developmental processes related to cartilage formation and vascular biology (cartilage development, blood circulation, VEGF receptor signaling, endothelial proliferation regulation). The presence of heparan sulfate proteoglycan metabolism/catabolism supports ECM-mediated signaling in these contexts. While a couple of terms (lipoteichoic acid biosynthesis, choline biosynthetic process) are less related, the dominant theme points to coordinated development of cartilage and blood vessels via Wnt signaling and ECM interactions.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060686","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0008015","count":2},{"id":"GO:0051216","count":2},{"id":"GO:0001937","count":2}]},{"hash":"645189213287093869","title":"Unknown","description":"These four proteins show no interactions (Edges: 0; Triangles: 0) and the top GO terms span disparate processes\u2014from lung connective tissue development and nipple morphogenesis to defense against Gram-positive bacteria and thrombin signaling. The combination includes phosphorylation, nucleotide metabolism, and other unrelated processes, with several terms being obsolete. There is no single coherent biological theme linking the proteins, so a concise functional label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060427","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0016310","count":1}]},{"hash":"1199346347921126248","title":"Neural development and axon/dendrite organization","description":"The GO terms are dominated by nervous system development, neurogenesis, nerve impulse transmission, dendrite self-avoidance, and paranodal axon localization, all pointing to neural development and axon/dendrite patterning. A couple of terms (salivary gland boundary specification and positive regulation of myoblast differentiation) are less consistent and may reflect broader developmental processes or neuromuscular junction contexts, but the central theme remains neural development and axon/dendrite organization.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050925","count":2},{"id":"GO:0022008","count":2},{"id":"GO:0002175","count":2},{"id":"GO:0007432","count":2},{"id":"GO:0030513","count":2}]},{"hash":"2054667599774151225","title":"Immune cell differentiation and signaling","description":"The terms cluster around immune and hematopoietic processes: neutrophil chemotaxis, B cell and monocyte differentiation, GM-CSF production, integrin-mediated signaling, and regulation of Wnt signaling, along with growth regulation in multicellular contexts. This suggests a cohesive theme of signaling pathways guiding immune cell development and trafficking, despite one term reflecting broader developmental processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":3},{"id":"GO:0045445","count":2},{"id":"GO:0045648","count":2},{"id":"GO:0030889","count":2},{"id":"GO:0090263","count":2}]},{"hash":"950206715993222967","title":"Lysosome and Endosome Trafficking with TOR Signaling","description":"This cluster centers on lysosome-associated processes (localization, organization, vacuolar acidification) and endosomal transport, plus microautophagy and positive regulation of TOR signaling. The convergence of lysosomal/endosomal dynamics with TOR pathway regulation suggests a cohesive role in nutrient sensing and intracellular degradation, with cholesterol-related terms likely ancillary. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":2},{"id":"GO:0010872","count":1},{"id":"GO:0001919","count":1},{"id":"GO:0032008","count":1},{"id":"GO:0016237","count":1}]},{"hash":"1167557411072937872","title":"Ubiquitin-Mediated Proteolysis and Chromatin Regulation","description":"The top terms cluster around ubiquitin-dependent protein catabolic processes and specific ubiquitination (K6-linked), plus histone catabolic processes and dosage compensation, suggesting a theme of protein turnover linked to chromatin regulation. While the signals point to a coherent function in ubiquitin signaling and chromatin dynamics, the small number of terms and proteins makes the connection modest rather than definitive.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":1},{"id":"GO:0036205","count":1},{"id":"GO:2000620","count":1},{"id":"GO:0009048","count":1},{"id":"GO:0085020","count":1}]},{"hash":"1300765255781913964","title":"Unknown","description":"The Top Terms are highly diverse, spanning olfactory development, lung mesenchyme, immune defense, Fc-gamma signaling, cardiac electrophysiology, neuroblast division, inflammatory cytokine regulation, melanocyte migration, and mechanoreceptor differentiation. With zero edges connecting the proteins and only singleton associations, there is no cohesive biological function or pathway that ties these proteins together. Therefore, a meaningful single-label name cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071699","count":1},{"id":"GO:0060484","count":1},{"id":"GO:0042742","count":1},{"id":"GO:0038096","count":1},{"id":"GO:0086014","count":1}]},{"hash":"398928877166234379","title":"Innate antiviral signaling and autophagy","description":"The dominant GO terms point to host defense against viruses, including RIG-I signaling, autophagy, and ubiquitin-mediated regulation, along with suppression of viral release and control of inflammatory cytokines like IL-1\u03b2. While a few terms (e.g., V(D)J recombination) are outside this theme, the cluster overall reflects innate antiviral signaling and protein turnover rather than a single viral life-cycle step.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901253","count":3},{"id":"GO:0050713","count":3},{"id":"GO:0033151","count":3},{"id":"GO:0046598","count":3},{"id":"GO:0051865","count":3}]},{"hash":"2273479306015974574","title":"ER-Golgi and endomembrane trafficking","description":"The dominant GO terms describe vesicle transport within the secretory and endomembrane system (ER\u2013Golgi, Golgi\u2013endosome, endosome\u2013Golgi, endocytic recycling) and protein localization processes, indicating a cohesive role in intracellular trafficking and localization rather to other processes. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0006886","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006895","count":2},{"id":"GO:0035646","count":2}]},{"hash":"1224066730681968627","title":"Unknown","description":"The top GO terms span mitochondrial assembly, antibiotic response, transcription regulation, xenobiotic and amino-acid catabolism, redox processes, glutathione metabolism, and protein modification, with no clear single function tying all terms together. The terms are diverse and the cluster has no connections (edges) to support a cohesive label, so Unknown is appropriate.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032981","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006357","count":1},{"id":"GO:0042178","count":1},{"id":"GO:0055114","count":1}]},{"hash":"240231039562836188","title":"Neuronal cytoskeletal remodeling and vesicle trafficking","description":"The top GO terms cluster around cytoskeletal assembly (filopodium, tubulin complex) and neuronal processes like axon guidance, alongside vesicle trafficking processes (vesicle docking, endocytosis). This points to a function in remodeling the neuronal cytoskeleton to support axon guidance and synaptic vesicle dynamics. Some unrelated placenta-related terms appear (likely noise), but the dominant signal centers on neuronal cytoskeletal remodeling and vesicle trafficking.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097345","count":2},{"id":"GO:0051496","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0001893","count":1}]},{"hash":"885323450523644251","title":"Glycogen and starch biosynthesis/regulation","description":"The cluster centers on carbohydrate metabolism, with GO terms indicating glycogen and starch biosynthesis and related regulation (glycogen metabolic process, positive regulation of glycogen synthase activity, amylopectin/starch biosynthesis). Supporting signals related to energy balance (leptin response, adipose development) suggest these proteins coordinate energy storage pathways. Overall, the terms converge on carbohydrate storage biosynthesis and its regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010021","count":2},{"id":"GO:0045725","count":2},{"id":"GO:2000467","count":2},{"id":"GO:0005981","count":2},{"id":"GO:0005977","count":2}]},{"hash":"1633772075207023735","title":"GPCR-Mediated Sensory Signaling","description":"The cluster\u2019s GO terms largely point to G protein-coupled receptor signaling, including taste receptor (sweet taste) detection and metabotropic glutamate receptor pathways, with downstream PLC and adenylate cyclase involvement. Although also touching on locomotion and sodium transport, the dominant theme is GPCR-driven signaling linked to sensory perception. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001582","count":2},{"id":"GO:0000187","count":2},{"id":"GO:0007196","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0051930","count":2}]},{"hash":"1273717829315062381","title":"Dendrite morphogenesis and synaptic signaling","description":"Based on the GO terms, the proteins are enriched for neuronal development and synaptic activity, including dendrite morphogenesis, nervous system development, excitatory postsynaptic potential, ephrin receptor signaling, and Ca2+-dependent exocytosis, with associated MAPK (ERK) signaling and Wnt pathways. This supports a coherent theme of shaping dendrites and mediating excitatory synaptic transmission. A minority of terms (like T cell receptor signaling) may reflect broader signaling cross-talk or annotation noise but do not dominate the cluster's function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048813","count":4},{"id":"GO:0031647","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0033138","count":4}]},{"hash":"1745997578381129925","title":"Antiviral Innate Immune Response via RNA Pol III","description":"The top terms strongly point to antiviral innate immunity: innate immune response, defense response to virus, and positive regulation of interferon-beta production suggest an antiviral signaling theme. The presence of RNA polymerase III\u2013related terms (tRNA transcription and regulation) may reflect a link between RNA Pol III activity and innate sensing, though several other terms (epinephrine biosynthesis, xenobiotic response, regeneration, RNA methylation) appear more peripheral or noisy. Overall, the core cluster seems best described by antiviral innate immune signaling with a possible note on RNA Pol III\u2013related transcriptional involvement.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":1},{"id":"GO:0006359","count":1},{"id":"GO:0051607","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0032728","count":1}]},{"hash":"145012896578688461","title":"Hormone Signaling and Epithelial Polarity","description":"The terms point to signaling pathways influenced by metabolic hormones (leptin response, insulin signaling) that also touch on epithelial cell behavior, including JUN phosphorylation, actin cytoskeleton organization, and polarized epithelial differentiation, as well as epithelial integrity. Although some terms are peripheral (forebrain development, fatty acid transport), the core cluster centers on how signaling modulates epithelial polarity and cytoskeletal dynamics. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044320","count":1},{"id":"GO:1903077","count":1},{"id":"GO:0030900","count":1},{"id":"GO:0010748","count":1},{"id":"GO:0051017","count":1}]},{"hash":"1335986810492043427","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0007317","count":4},{"id":"GO:0009951","count":4},{"id":"GO:0071031","count":4},{"id":"GO:0000390","count":4},{"id":"GO:0000462","count":4}]},{"hash":"1570082674110085549","title":"APC/C-Mediated Proteolysis in Mitosis","description":"This cluster is dominated by ubiquitin-dependent protein catabolic processes and mitotic cell cycle terms, notably K11-linked ubiquitination and anaphase-promoting complex (APC/C)-dependent proteolysis. Together with mitotic-cycle signals, the proteins likely coordinate regulated proteolysis during mitosis, so the label APC/C-Mediated Proteolysis in Mitosis fits.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0070979","count":3},{"id":"GO:2001162","count":3},{"id":"GO:0061087","count":3}]},{"hash":"1567078981081718847","title":"Neuronal excitability and synaptic signaling","description":"The GO terms emphasize ion transport (sodium and potassium) with membrane depolarization, excitatory postsynaptic potentials, and action potentials, plus postsynaptic membrane organization and sensory processing, highlighting neuronal signaling and excitability; a few terms are peripheral but do not override the core neuronal theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0051899","count":2},{"id":"GO:0060079","count":2},{"id":"GO:2001046","count":2}]},{"hash":"216611506396240014","title":"Dopaminergic GPCR Signaling and Feeding Behavior","description":"This cluster is dominated by GO terms for dopaminergic synaptic transmission, eating behavior, and GPCR signaling linked to cGMP, suggesting a neuromodulatory role in feeding/reward circuits powered by dopaminergic GPCR pathways. While a few terms touch on other systems, the strongest signal centers on dopaminergic GPCR-mediated signaling related to feeding. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":4},{"id":"GO:0042755","count":4},{"id":"GO:0001963","count":4},{"id":"GO:0007199","count":4},{"id":"GO:1900134","count":4}]},{"hash":"100256165383158696","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048536","count":2},{"id":"GO:0022037","count":2},{"id":"GO:0007014","count":1},{"id":"GO:1903762","count":1},{"id":"GO:0002635","count":1}]},{"hash":"1844674205630930478","title":"Ubiquitin-Dependent Protein Quality Control","description":"The proteins cluster around ubiquitination and proteasome-mediated turnover, with GO terms for ubiquitin chain formation (K6, K48), autoubiquitination, and cytoplasmic quality control by the ubiquitin-proteasome system, plus a peroxisomal import receptor recycling step tied to ubiquitination. A single immune-signaling term appears but does not define the cluster; overall, the dominant theme is ubiquitin-dependent protein targeting and degradation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0016562","count":4},{"id":"GO:0010994","count":4},{"id":"GO:0002223","count":4},{"id":"GO:1903955","count":4},{"id":"GO:0051865","count":4}]},{"hash":"668334984030663516","title":"Neuronal RNA Granules and Synaptic Plasticity","description":"The top GO terms center on RNA granule biology (stress granules, cytoplasmic mRNA processing bodies, and mRNA decay) alongside neuronal functions related to learning and synaptic regulation, suggesting a theme of RNA granule dynamics in neurons that influence synaptic plasticity. This combination points to a cohesive function linking RNA metabolism in neuronal granules with activity-dependent neural processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010603","count":2},{"id":"GO:0022416","count":2},{"id":"GO:0034063","count":2},{"id":"GO:0000288","count":2},{"id":"GO:1900271","count":2}]},{"hash":"199801326498104401","title":"Clathrin-mediated endocytosis and vesicle sorting","description":"The top GO terms cluster around endocytosis and vesicle trafficking, including clathrin coat assembly, receptor-mediated endocytosis, and multivesicular body sorting, suggesting a shared function in membrane traffic. Some apoptosis- and amyloid-related terms appear, which may reflect cross-talk between trafficking and apoptotic or APP-processing pathways, but the dominant signal is endocytic/vesicle sorting activity. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006919","count":2},{"id":"GO:1901030","count":2},{"id":"GO:0071985","count":2},{"id":"GO:0048260","count":2},{"id":"GO:1905445","count":2}]},{"hash":"2080232217050303820","title":"Neuronal differentiation and synaptic adhesion","description":"The terms point to neural development and connectivity: neuroepithelial differentiation, dopaminergic neuron axon guidance, heterophilic cell-cell adhesion, and postsynaptic density clustering are all neuronal in nature, with retina homeostasis reflecting neural tissue maintenance and Purkinje cell adhesion indicating synaptic contacts. The opposite terms (ureter maturation, IGF signaling regulation) are less central and do not override the neural-focused pattern.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001895","count":2},{"id":"GO:0043568","count":1},{"id":"GO:0060563","count":1},{"id":"GO:0035799","count":1},{"id":"GO:0045463","count":1}]},{"hash":"622919239499018097","title":"Unknown","description":"The GO terms are diverse, including nervous system development and signaling, various tissue morphogenesis (olfactory placode, salivary gland, lung mesenchyme), immune processes, and cardiac muscle electrophysiology. There isn\u2019t a single coherent function linking the proteins, so there is no clear, representative label beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021682","count":2},{"id":"GO:0019226","count":2},{"id":"GO:0060445","count":2},{"id":"GO:0001923","count":1},{"id":"GO:0071699","count":1}]},{"hash":"1250479485779300439","title":"Mitotic Regulation and Ubiquitin-Proteasome Pathways","description":"The strongest signals are mitosis-related: G2/M transition, chromosome segregation, and exit from mitosis, along with SCF-dependent ubiquitin-proteasomal degradation, implying a cluster of proteins involved in mitotic control and targeted protein turnover. Additional terms like nucleotide-excision repair and ubiquitin polymerization support a broader link to DNA damage responses and ubiquitin signaling that can intersect with cell cycle regulation. Overall, the cluster appears to center on mitotic regulation and ubiquitin-mediated proteolysis.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0000086","count":4},{"id":"GO:0007059","count":4},{"id":"GO:0010458","count":4},{"id":"GO:0070911","count":4},{"id":"GO:0016032","count":4}]},{"hash":"1876122282860106032","title":"Proteostasis and Organelle Quality Control","description":"This cluster shows enrichment in protein quality control pathways across organelles: autophagosome maturation, stress granule disassembly, misfolded protein response, and proteasomal degradation, along with organelle biogenesis/assembly processes (mitochondrial complex III assembly and peroxisome import). The combined GO terms point to a cohesive theme of maintaining protein homeostasis and organelle function across cellular compartments.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097352","count":3},{"id":"GO:0016562","count":3},{"id":"GO:0035617","count":3},{"id":"GO:1901800","count":3},{"id":"GO:1903715","count":3}]},{"hash":"838953501619147287","title":"Blood Vessel Formation and Hematopoiesis","description":"The GO terms cluster around vascular and blood cell development: angioblast differentiation, erythrocyte differentiation, blood circulation, and blood vessel morphogenesis, with related immune and epithelial remodeling processes. This points to a shared theme of hematovascular development, even though the proteins show no direct interactions in this cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001866","count":4},{"id":"GO:0001712","count":4},{"id":"GO:0045648","count":4},{"id":"GO:1902262","count":4},{"id":"GO:0035779","count":4}]},{"hash":"428817295910483815","title":"Neurodevelopment and sensory neuron differentiation","description":"This cluster is enriched for terms involved in neural development and sensory neuron function, including neurogenesis, transmission of nerve impulses, mechanoreceptor differentiation, olfactory placode morphogenesis, and paranode axon localization, suggesting a cohesive role in nervous system development and sensory neuron maturation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":2},{"id":"GO:0071699","count":1},{"id":"GO:0060484","count":1},{"id":"GO:0050925","count":1},{"id":"GO:0021847","count":1}]},{"hash":"1645783056024719528","title":"Unknown","description":"The GO terms span disparate organisms and processes\u2014plant development (lateral root development, acropetal auxin transport), insect sensory/behavior (proboscis extension reflex, nose development), and broad cellular responses to various stimuli (glucagon, prostaglandin, catecholamines, pheromone signaling). There isn\u2019t a clear, cohesive function uniting these across the proteins, so a specific label isn\u2019t supported.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071377","count":1},{"id":"GO:0048527","count":1},{"id":"GO:0071380","count":1},{"id":"GO:0007637","count":1},{"id":"GO:0048383","count":1}]},{"hash":"2126622747582433976","title":"Cardiac and Smooth Muscle Contraction Regulation","description":"The top terms point to regulation and relaxation of heart and vascular smooth muscle, including positive/negative regulation of cardiac contraction and smooth muscle relaxation, implying a signaling module tied to muscle contractility. Some terms (Wnt signaling in neural plate patterning, zygote division) appear unrelated and may be noise, but the core theme centers on muscle contraction regulation and associated signaling.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060452","count":1},{"id":"GO:0003108","count":1},{"id":"GO:0031914","count":1},{"id":"GO:0010070","count":1},{"id":"GO:0060823","count":1}]},{"hash":"1243696845628484360","title":"Embryonic Development and Tissue Morphogenesis","description":"Core pattern is embryonic tissue morphogenesis across multiple lineages (placenta, mesoderm, cartilage, hair follicles, craniofacial structures, endocrine organs), indicating a general developmental program rather than a single tissue-specific function.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0031069","count":3},{"id":"GO:0010957","count":3},{"id":"GO:0060806","count":3}]},{"hash":"527463884218769400","title":"Antiviral immunity and ubiquitin signaling","description":"The top GO terms cluster around antiviral host responses and regulation of immune signaling, including negative regulation of viral material transport, RIG-I signaling, autophagy, and ubiquitin-related processes. There are also immune system components (e.g., V(D)J recombination, IL-1\u03b2 regulation) and viral entry/suppression dynamics, suggesting a theme of host defense mechanisms modulated by ubiquitination and autophagy. While some terms are broader or tangential (e.g., synaptic transport), the common thread appears to be antiviral defense and ubiquitin-regulated pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1901253","count":4},{"id":"GO:0050713","count":4},{"id":"GO:0033151","count":4},{"id":"GO:0046598","count":4},{"id":"GO:0051865","count":4}]},{"hash":"1558810370096988969","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016321","count":1},{"id":"GO:2000344","count":1},{"id":"GO:2000884","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0016042","count":1}]},{"hash":"840591277702128250","title":"Actin-dependent secretory vesicle trafficking","description":"Top GO terms point to actin cytoskeleton dynamics (actin filament bundle distribution; actin cortical patch assembly) and vesicle-related processes (vesicle docking in exocytosis; secretory granule localization; positive regulation of protein targeting to membrane). The combination suggests a functional theme where actin structures coordinate vesicle trafficking and secretion. With only 3 proteins and no reported edges, the cluster appears to reflect this shared function rather than a highly connected module.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070650","count":1},{"id":"GO:0006904","count":1},{"id":"GO:0032252","count":1},{"id":"GO:0000011","count":1},{"id":"GO:0031276","count":1}]},{"hash":"35293150128155668","title":"Ciliogenesis and Intraciliary Transport","description":"The top terms cluster around cilium formation and transport within the cilium, including intraciliary transport involved in cilium assembly, intraciliary retrograde transport, and motile cilium assembly. Other terms touch on related developmental processes, but the strongest, most coherent signal is proteins involved in building and moving components inside cilia. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051292","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0022416","count":2},{"id":"GO:0008039","count":2},{"id":"GO:0035735","count":2}]},{"hash":"537503725029059656","title":"Metabolic hormone signaling and adipose development","description":"The GO terms center on regulation of insulin secretion, adipose tissue development, leptin and estrogen responses, and sterol/bile acid metabolism, pointing to a core theme of hormonal control of metabolism and fat biology; a few items like ureteric bud development and cell adhesion may indicate broader developmental signaling roles.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050796","count":2},{"id":"GO:0001657","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0010871","count":1},{"id":"GO:0070858","count":1}]},{"hash":"1978179259408119258","title":"Sterol and lipid metabolism with hormone signaling","description":"GO terms center on lipid and sterol metabolism and hormone signaling (triglyceride homeostasis, bile acid biosynthesis, responses to leptin, estrogen, and androgen). This points to a function in lipid regulation linked to steroid/hormone pathways; with a small protein set, the confidence is moderate.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010871","count":1},{"id":"GO:0070858","count":1},{"id":"GO:0008209","count":1},{"id":"GO:1904179","count":1},{"id":"GO:0044320","count":1}]},{"hash":"32157168314193829","title":"Unknown","description":"The top GO terms span transcription, kinase activation, development (liver and trophectoderm morphogenesis), chromosomal segregation, DNA repair regulation, mitotic cell cycle, and neural plasticity, with no single unifying function or known interaction tying the proteins together. Because edges are zero, the cluster appears functionally heterogeneous, so no specific label can be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0032147","count":2},{"id":"GO:0072576","count":1},{"id":"GO:0035518","count":1},{"id":"GO:0051759","count":1}]},{"hash":"1540634324320728673","title":"Unknown","description":"The top GO terms span disparate biological areas, with several pointing to membrane lipid and sterol metabolism (unsaturated fatty acid biosynthesis, MIPC metabolism, ergosterol biosynthetic regulation) but others describing unrelated processes (myelin maintenance, sebaceous gland differentiation, nitrate assimilation, mitochondrial inheritance). With no clear, cohesive function linking all three proteins, there isn\u2019t a single interpretable theme to assign a specific label.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0006809","count":3},{"id":"GO:0000001","count":3}]},{"hash":"1941821951473571407","title":"Proton and ion transport across membranes","description":"The GO terms cluster around transmembrane movement of ions (protons, potassium, calcium, sodium) and energy-coupled transport, e.g., proton translocation driving ATP synthesis, plus ion homeostasis across membranes. Although a couple terms are obsolete or peripheral, the dominant theme is membrane ion transport and maintenance of ionic gradients.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":2},{"id":"GO:0042773","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0051208","count":1},{"id":"GO:1901205","count":1}]},{"hash":"918236216042498347","title":"Unknown","description":"The top GO terms cover metal ion transport/homeostasis, development, nucleotide and fatty acid metabolism, amino acid biosynthesis, and stress responses with no single unifying function. In particular, retina development is tissue-specific and unrelated to the metabolic terms, suggesting the cluster lacks a cohesive biological theme. Therefore, a precise, representative label cannot be assigned with confidence.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903830","count":1},{"id":"GO:0010960","count":1},{"id":"GO:0019343","count":1},{"id":"GO:0060041","count":1},{"id":"GO:0006177","count":1}]},{"hash":"1459178207571389702","title":"Unknown","description":"This cluster's GO terms are very heterogeneous, spanning neural and organ morphogenesis, DNA repair, immune signaling, and various metabolic/response processes, with no clear single function tying the proteins together. With such diversity and only three proteins, a specific, representative label cannot be confidently assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":3},{"id":"GO:1990804","count":3},{"id":"GO:0033598","count":3},{"id":"GO:0002688","count":3},{"id":"GO:0071380","count":3}]},{"hash":"2152783316245563742","title":"Chaperone-Mediated Folding and Stabilization","description":"The cluster centers on chaperone-related processes: chaperone-mediated protein folding, chaperone complex assembly, and protein stabilization, with additional signals of immune/inflammatory regulation. The presence of isotype switching to IgG and stress/response terms (to cocaine and cadmium) suggests a broader role for protein quality control in immune cells under stress.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048291","count":3},{"id":"GO:0051086","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0046686","count":3},{"id":"GO:0014823","count":3}]},{"hash":"1866813032191203945","title":"Axonogenesis and Neurogenesis Regulation","description":"This cluster centers on neural development with GO terms for axonogenesis, neurogenesis, and receptor tyrosine kinase signaling, as well as downstream PI3K/AKT and BMP pathways. The presence of both positive regulation of axonogenesis and negative regulation of axon extension suggests a module that fine-tunes axon growth during neuronal differentiation. Paranode localization further supports a neuronal, axon-structure\u2013related role. A few terms (like salivary gland boundary specification) may be incidental annotations rather than core functions. Overall, the cluster reflects coordinated regulation of neuron formation and axon growth.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048692","count":3},{"id":"GO:1902997","count":3},{"id":"GO:0050772","count":3},{"id":"GO:0050925","count":3},{"id":"GO:0007169","count":3}]},{"hash":"923226968085293861","title":"Synaptic vesicle exocytosis regulation","description":"These terms cluster around vesicle trafficking and exocytosis control, especially synaptic vesicle exocytosis regulation, vesicle fusion, and calcium-dependent exocytosis. The inclusion of multivesicular body sorting and endocytosis regulation reinforces a common theme of intracellular vesicle trafficking pathways, which can relate to neuronal development (brain development) and general vesicle dynamics. A few immune-related terms may reflect broader roles of vesicle trafficking in immune cells or annotation noise. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":3},{"id":"GO:0010796","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0071985","count":2}]},{"hash":"986491431057634900","title":"Proteostasis and Mitochondrial Quality Control","description":"The terms cluster around protein quality control and stress responses: mitophagy, aggresome assembly, ubiquitination and sumoylation, deglycosylation, and ER-stress\u2013related regulation of apoptosis, plus mitochondrial fusion dynamics. These collectively point to maintaining protein homeostasis and mitochondrial integrity, despite some outlier terms (erythrocyte differentiation, TNF signaling) that may be incidental. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902236","count":3},{"id":"GO:0045648","count":3},{"id":"GO:0033132","count":3},{"id":"GO:0000423","count":3},{"id":"GO:0051865","count":3}]},{"hash":"711957278756067600","title":"Unknown","description":"The top terms are highly diverse and even include obsolete GO terms, spanning amino acid biosynthesis, catabolic processes, metal/selenium metabolism, bacterial host entry, vitamin B6 biosynthesis, and circadian rhythm. With only three proteins and no reported interactions (0 edges), there is no cohesive functional theme tying them together. Therefore, I cannot assign a meaningful label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0009099","count":1},{"id":"GO:0035635","count":1},{"id":"GO:0001887","count":1},{"id":"GO:0046392","count":1}]},{"hash":"219307078510684087","title":"Neural development and behavior","description":"Top terms center on brain development and neural function (midbrain development, forebrain morphogenesis, adult walking behavior, eating behavior) and neuronal cargo transport (axonal transport of mitochondrion), suggesting a neural development/behavioral module. A few terms for DNA recombination/repair and segmental identity appear as minor outliers, indicating some non-neural processes are present but the dominant signal is neural development and behavior.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019896","count":1},{"id":"GO:0042755","count":1},{"id":"GO:0030901","count":1},{"id":"GO:0007628","count":1},{"id":"GO:0006310","count":1}]},{"hash":"2254205845074160751","title":"C-type lectin and Fc receptor signaling cluster","description":"The top GO terms point to innate immune signaling through pattern-recognition and Fc receptor pathways\u2014stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, and NK cell chemotaxis regulation\u2014suggesting these proteins function in innate immune sensing and effector responses. Some terms about morphogenesis may be ancillary annotations or cross-talk, but the central theme is immune receptor\u2013mediated signaling.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":3},{"id":"GO:0060355","count":3},{"id":"GO:0036303","count":3},{"id":"GO:0072287","count":3},{"id":"GO:0071226","count":3}]},{"hash":"192309735619251461","title":"Hair follicle keratinization and skin morphogenesis","description":"The GO terms point most strongly to skin-related processes (hair follicle morphogenesis, keratinization, multicellular growth) with supporting general cellular functions (cell cycle, vesicle transport, GPCR signaling). The presence of dendrite morphogenesis introduces some unrelated signals, but the core theme appears to be skin development and keratinocyte differentiation, with vesicle trafficking supporting secretion in developing hair/skin structures.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007200","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0031424","count":2},{"id":"GO:0048813","count":2}]},{"hash":"949364361389027180","title":"Unknown","description":"The GO terms are highly diverse and mostly one-off, with several obsolete annotations and no clear shared function or pathway linking the proteins. There are no interactions or cohesive themes to support a specific label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003335","count":1},{"id":"GO:2001153","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0046856","count":1},{"id":"GO:2000327","count":1}]},{"hash":"35913844475254541","title":"Epidermal cell surface signaling and proteolysis","description":"This cluster centers on GO terms related to cell surface signaling and processing in epidermal/epithelial contexts, including integrin-mediated signaling, Notch signaling, keratinocyte differentiation, and ectodomain proteolysis of membrane proteins, with links to inflammation and immune regulation. These shared themes point to epidermal cell surface communication and proteolytic activation as the key motif.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:0000186","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0010765","count":2},{"id":"GO:0051089","count":1}]},{"hash":"521132329676576401","title":"Unknown","description":"Top terms span several unrelated processes, including heme/porphyrin biosynthesis and iron-sulfur cluster assembly, fatty acid metabolism/transport, vitamin B6 response, amino acid biosynthesis, and Notch signaling. With such diverse functions and only a small cluster, there is no clear single theme linking the proteins; hence no confident, representative label can be assigned.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006533","count":1},{"id":"GO:0006782","count":1},{"id":"GO:0055089","count":1},{"id":"GO:0007219","count":1},{"id":"GO:0006571","count":1}]},{"hash":"10237439765462522","title":"Unknown","description":"The GO terms are diverse and include ion export, lipid metabolism, hormonal responses, and plant-specific stilbene catabolism; with only three proteins and no edges, there is no clear shared function or pathway uniting the cluster, so a single interpretable label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":1},{"id":"GO:0051208","count":1},{"id":"GO:1901205","count":1},{"id":"GO:0097623","count":1},{"id":"GO:0033574","count":1}]},{"hash":"1173615434872066097","title":"Unknown","description":"The GO terms are highly diverse, spanning transcriptional regulation, neural crest and various developmental processes (pituitary, parasympathetic NS, septum development) and even an obsolete/regulatory term, with no clear unifying function for the cluster of three proteins. This makes it hard to assign a coherent, specific label.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0014029","count":1},{"id":"GO:0021920","count":1},{"id":"GO:2000346","count":1},{"id":"GO:0010201","count":1}]},{"hash":"1401825379267184155","title":"Innate immune receptor signaling and leukocyte activation","description":"The cluster is dominated by GO terms related to innate immune sensing and leukocyte activation, including stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, basophil activation, cellular response to fungal origin, and NK cell chemotaxis modulation. A few development-related terms (lymph vessel, mesonephric duct, metanephric morphogenesis) may reflect broader roles or annotation noise, but the core signal points to immune receptor pathways and leukocyte activation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":1},{"id":"GO:0060355","count":1},{"id":"GO:0036303","count":1},{"id":"GO:0072287","count":1},{"id":"GO:0071226","count":1}]},{"hash":"1347306297070441388","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019305","count":3},{"id":"GO:0097171","count":3},{"id":"GO:0006541","count":3},{"id":"GO:0006012","count":3},{"id":"GO:0080110","count":3}]},{"hash":"197462726627489483","title":"Membrane Lipid Biosynthesis and Metal Transport","description":"The highest-frequency GO term is lipopolysaccharide biosynthetic process, complemented by multiple metal ion transport terms (copper, zinc, cadmium) and a phospholipid dephosphorylation term, all hinting at membrane-associated metabolism and ion homeostasis. While a few other terms appear (testosterone response, stilbene catabolic process, serine biosynthesis), the dominant signal is membrane-related biosynthesis and metal transport, justifying a label focused on these processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:0006874","count":1},{"id":"GO:0097755","count":1},{"id":"GO:0033574","count":1},{"id":"GO:0006825","count":1}]},{"hash":"727996455456004485","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031247","count":1},{"id":"GO:0030836","count":1},{"id":"GO:0006470","count":1},{"id":"GO:0046050","count":1},{"id":"GO:0032361","count":1}]},{"hash":"23312731323019432","title":"Organogenesis and angiogenesis","description":"GO terms indicate involvement in development of multiple organs (spinal cord patterning, proximal tubule and loop of Henle development, blood-brain barrier maintenance) along with vascular processes (endothelial proliferation, sprouting angiogenesis, Notch signaling). This suggests a theme of organogenesis coupled with vascular development, despite a noisy obsolete oxidation-reduction term. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0048513","count":1},{"id":"GO:0035633","count":1},{"id":"GO:0010593","count":1},{"id":"GO:0021511","count":1}]},{"hash":"239460215402711771","title":"DNA-templated transcription","description":"The dominant signal is GO:0006351, DNA-templated transcription, represented by multiple proteins in the cluster, suggesting a core role in transcriptional control. Additional terms point to regulatory chromatin-related activities and modest links to development/hormone signaling (e.g., regulation of estradiol secretion, vasculogenesis, myoblast differentiation) but the unifying theme remains transcriptional regulation at the DNA level. Confidence in this labeling is High.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:1901726","count":1},{"id":"GO:2000864","count":1},{"id":"GO:0061428","count":1},{"id":"GO:2001214","count":1}]},{"hash":"272184427751730714","title":"Cardiovascular Inflammation and Development","description":"This cluster combines clear inflammatory signals (sensory pain, inflammatory response, lipopolysaccharide response, coagulation, vasoconstriction) with cardiovascular/vascular development cues (venous endothelial differentiation, heart morphogenesis, Notch signaling in heart field, multicellular development). The Bone-related term seems incidental, not central to the main theme. Overall, the proteins likely participate in inflammation linked to heart/vascular formation. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0006954","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0003213","count":2},{"id":"GO:0032496","count":2}]},{"hash":"248691741619337176","title":"Developmental Morphogenesis","description":"The top GO terms cluster around embryonic development and tissue morphogenesis across diverse lineages (neural plate development, ectoderm development, embryonic body morphogenesis, oocyte localization, oviduct development, metanephros morphogenesis). This suggests a broad theme of developmental processes, despite a few outliers (plant-type cell wall biogenesis, vacuole inheritance, regulation of heart rate) and the absence of known protein\u2013protein interactions within the cluster. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009833","count":1},{"id":"GO:0086091","count":1},{"id":"GO:0001840","count":1},{"id":"GO:0010172","count":1},{"id":"GO:0000011","count":1}]},{"hash":"823105363224297717","title":"Vesicle trafficking and secretion","description":"The proteins are enriched for GO terms involving intracellular transport of vesicles, Golgi-related trafficking, and various secretion processes (mucus secretion, synaptic vesicle exocytosis, neutrophil degranulation), suggesting a common role in vesicle formation, transport, and release.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":1},{"id":"GO:0070254","count":1},{"id":"GO:0016240","count":1},{"id":"GO:0090316","count":1},{"id":"GO:0090161","count":1}]},{"hash":"1108277726801400073","title":"Unknown","description":"The GO terms are spread across diverse developmental and signaling processes (melanocyte differentiation, olfactory placode morphogenesis, lung mesenchyme development, ventricular zone neuroblast division, dopamine receptor signaling, luteinizing hormone signaling, and various regulatory activities). There isn\u2019t a single coherent function or pathway tying all proteins together, so a specific, representative label is not justifiable.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030318","count":3},{"id":"GO:0032516","count":2},{"id":"GO:0051770","count":2},{"id":"GO:0071699","count":2},{"id":"GO:1902499","count":2}]},{"hash":"964407831635079308","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0007014","count":1},{"id":"GO:1903762","count":1}]},{"hash":"522844095756809719","title":"Nuclear transport and mitotic regulation","description":"The dominant GO terms point to nuclear transport (regulation of protein import into nucleus; tRNA export from nucleus) and mitotic processes (mitotic nuclear membrane disassembly; mitotic metaphase chromosome alignment). Additional terms on protein oligomerization and intracellular transport of virus align with broader trafficking/assembly roles, while a glucose transport term is more peripheral. Overall, the cluster seems centered on nuclear transport combined with cell cycle regulation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010827","count":3},{"id":"GO:0007077","count":3},{"id":"GO:0042306","count":3},{"id":"GO:0006409","count":3},{"id":"GO:0075733","count":3}]},{"hash":"251816015394146072","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007014","count":2},{"id":"GO:1903762","count":2},{"id":"GO:0061158","count":2},{"id":"GO:1901253","count":2},{"id":"GO:2000653","count":2}]},{"hash":"2025760421791164570","title":"RNA processing and RNAi-mediated gene silencing","description":"This cluster centers on post-transcriptional RNA metabolism, with GO terms for mRNA polyadenylation, regulation of mRNA stability, and gene silencing via mRNA cleavage, plus RISC complex assembly. While there are also related RNA processing activities like tRNA splicing and Pol I transcription termination, the strongest signal is RNA maturation and RNA interference machinery, justifying a label around RNA processing and RNA silencing.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0098789","count":1},{"id":"GO:0021695","count":1},{"id":"GO:0030423","count":1}]},{"hash":"1309318077203567467","title":"Organ and neural development","description":"The top GO terms cluster around development and morphogenesis across multiple organs (kidney, olfactory placode, outer ear) and neural tissue (ventricular zone neuroblast division, nerve maturation), with supporting cell\u2013cell adhesion and some immune development terms. Overall, the shared theme is developmental biology focused on organ and nervous system formation, though there is some diversity in immune-related terms. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0001923","count":2},{"id":"GO:0071699","count":2},{"id":"GO:0050925","count":2}]},{"hash":"1075071623285947224","title":"DNA Damage Response via Ubiquitin and SUMO","description":"The top terms highlight post-translational modifications (ubiquitination and SUMOylation) and DNA damage response processes (checkpoint regulation, DSB association with the nuclear envelope, and translesion synthesis regulation). This points to a theme of DDR regulation mediated by ubiquitin/SUMO pathways, with some developmental terms present likely due to broader gene annotations.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0003007","count":1},{"id":"GO:1904290","count":1},{"id":"GO:0033235","count":1},{"id":"GO:1904333","count":1}]},{"hash":"30190847107661954","title":"Developmental Morphogenesis","description":"Top GO terms point to morphogenesis across different tissues (dendrite morphogenesis, outer ear morphogenesis, mammary gland epithelial cell proliferation), suggesting a shared role in developmental shaping rather than a single pathway. Other terms (DNA repair, signaling responses) appear incidental. Thus, labeling this cluster as Developmental Morphogenesis captures the most representative theme, with moderate confidence due to the small size and heterogeneous annotations.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":3},{"id":"GO:1990804","count":3},{"id":"GO:0033598","count":3},{"id":"GO:0002688","count":3},{"id":"GO:0071380","count":3}]},{"hash":"1545137542186673513","title":"Ubiquitin-mediated regulation of apoptosis and chromatin","description":"The GO terms cluster around ubiquitination (protein ubiquitination, autoubiquitination, K6- and K48-linked), regulation of apoptotic processes, TNF signaling, and chromatin-related processes (histone catabolic process, V(D)J recombination, dosage compensation). Together these suggest a group of proteins involved in ubiquitin-dependent control of protein stability, signaling, and chromatin dynamics, justifying this label.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901253","count":2},{"id":"GO:0033151","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0085020","count":2},{"id":"GO:0070936","count":2}]},{"hash":"1467361085032746656","title":"Neuronal morphogenesis and vesicle trafficking","description":"The cluster is dominated by GO terms linked to nervous system development, brain development, and dendrite morphogenesis, along with vesicle transport and SNARE complex disassembly. This suggests a cohesive theme of neuronal differentiation and synaptic vesicle dynamics, despite some broader terms present. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048813","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0035494","count":2},{"id":"GO:0044319","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1439309756833401826","title":"Viral infection cycle and proviral latency","description":"The terms collectively map to a typical viral life cycle: entry into host cells (endocytosis), RNA-templated DNA synthesis, genome integration, recombination, and establishment of integrated proviral latency. This pattern points to proteins involved in viral infection and maintenance of proviral genomes rather than standard cellular processes, justifying a label centered on viral entry, replication, and latency.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075732","count":1},{"id":"GO:0006278","count":1},{"id":"GO:0043137","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0090502","count":1}]},{"hash":"901922111748986094","title":"Immune activation and complement signaling","description":"These proteins cluster around immune system functions: complement activation (classical pathway), B and T cell signaling and activation, phagocytosis, and responses to lipopolysaccharide. A few terms (heart development, sodium ion transport) appear as outliers, but the dominant GO terms point to immune recognition and activation. Therefore, the label Immune activation and complement signaling captures the core theme.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006911","count":2},{"id":"GO:0050870","count":2},{"id":"GO:0050853","count":2}]},{"hash":"885525334498940623","title":"Pyrimidine nucleotide metabolism","description":"Based on the GO terms, the dominant theme is pyrimidine nucleotide metabolism, including dUMP/dUTP/dITP catabolic and biosynthetic processes and pyrimidine ribonucleotide biosynthesis. The RNA processing terms present appear incidental rather than forming a cohesive RNA-processing module, so the main signal is pyrimidine nucleotide metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035863","count":1},{"id":"GO:0006226","count":1},{"id":"GO:0046081","count":1},{"id":"GO:0009220","count":1},{"id":"GO:0006229","count":1}]},{"hash":"668764996877370180","title":"Membrane transporters for ions and sugars","description":"The top GO terms are dominated by transmembrane transport of diverse solutes (D-xylose, organic cations, trehalose, sodium, potassium, selenite) and associated osmotic stress and nutrient-response processes, pointing to a shared function in membrane transport of ions/sugars and osmotic regulation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015753","count":3},{"id":"GO:0070715","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0035725","count":3},{"id":"GO:1904728","count":3}]},{"hash":"1966369168390176326","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071031","count":1},{"id":"GO:0000390","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0000349","count":1},{"id":"GO:0006260","count":1}]},{"hash":"742543867740759519","title":"Neuronal development and neurite morphogenesis","description":"The cluster\u2019s top GO terms cluster around neuronal development and neurite morphogenesis, including dendrite morphogenesis, axon extension, neuron development, and migration, plus sensory contexts like retinal rod cell and neuromast hair cell development. This suggests a coherent theme of neuronal differentiation and neurite outgrowth across CNS and sensory neuron contexts.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045494","count":1},{"id":"GO:0048813","count":1},{"id":"GO:1900181","count":1},{"id":"GO:0035556","count":1},{"id":"GO:0021860","count":1}]},{"hash":"1466583135516378376","title":"Neural development and CSF ion transport","description":"The terms cluster around brain development (pyramidal neuron development, brain morphogenesis) and brain fluid regulation via ion transport (chloride, bicarbonate, borate transport, cerebrospinal fluid secretion, pH regulation). This suggests proteins involved in neural development coupled with maintaining the brain extracellular ionic environment and CSF dynamics.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021860","count":1},{"id":"GO:0010036","count":1},{"id":"GO:0042044","count":1},{"id":"GO:0035445","count":1},{"id":"GO:0015701","count":1}]},{"hash":"434655399669094290","title":"Dopaminergic GPCR Signaling and Feeding Behavior","description":"The top GO terms cluster around dopaminergic synaptic transmission and GPCR signaling, including a link to cGMP-mediated pathways and explicit eating behavior, which together point to a dopamine-driven neural module regulating feeding. Some other terms (immune defense, heat generation, vascular effects) seem ancillary or incidental, so the core theme is dopamine-related neuronal signaling tied to feeding. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046960","count":1},{"id":"GO:0042755","count":1},{"id":"GO:0001963","count":1},{"id":"GO:0007199","count":1},{"id":"GO:1900134","count":1}]},{"hash":"1971501767589320719","title":"Ubiquitin-mediated protein degradation","description":"The top GO terms are dominated by ubiquitination-related processes (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, K6-linked ubiquitination) with related regulatory roles in apoptosis and signaling. This suggests a theme around ubiquitin pathways controlling protein turnover and regulation, though the small protein set and diverse terms limit strong specificity; thus a Medium confidence.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:1901253","count":2},{"id":"GO:0033151","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0085020","count":2}]},{"hash":"450324320447989648","title":"Translation initiation and preinitiation complex assembly","description":"This cluster is dominated by GO terms tied to translation, including cytoplasmic and mitochondrial translation, eukaryotic initiation factor 3 complex assembly, and formation of the translation preinitiation complex, pointing to a role in the machinery that initiates and regulates protein synthesis. A few terms (deneddylation, transcription regulation, and neural growth factor response) appear peripheral but do not override the core translation-focused signal; nuclear mRNA surveillance also fits with translational quality control.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":1},{"id":"GO:0032543","count":1},{"id":"GO:1990090","count":1},{"id":"GO:0000338","count":1},{"id":"GO:0070196","count":1}]},{"hash":"88872877089684133","title":"Inorganic cation transport","description":"This cluster's top GO term is GO:0015672 for inorganic cation transmembrane transport, though it is marked obsolete. With only one annotation among three proteins and limited connectivity, the association is tentative; the cluster may reflect a general theme of ion transport across membranes, but confidence is low due to sparse evidence.","confidence":"Low","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015672","count":1}]},{"hash":"1844737381728888301","title":"Chromatin organization and nucleosome assembly","description":"The cluster shows shared association with chromatin-level processes\u2014heterochromatin organization, nucleosome assembly, and histone modifications\u2014suggesting a function in establishing and maintaining chromatin structure.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070828","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0016584","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0097298","count":2}]},{"hash":"877224860679027767","title":"Triglyceride and Phospholipid Catabolism","description":"The cluster is enriched for triglyceride catabolic processes, triglyceride mobilization, triglyceride acyl-chain remodeling, and phospholipid catabolic processes, indicating lipid breakdown/remodeling functions.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036153","count":3},{"id":"GO:2000480","count":3},{"id":"GO:0046338","count":3},{"id":"GO:0010898","count":3},{"id":"GO:0034638","count":3}]},{"hash":"412982972235899203","title":"Glutamatergic postsynaptic density organization","description":"These GO terms converge on postsynaptic density assembly and regulation of excitatory synaptic signaling, especially glutamatergic transmission. Terms like postsynaptic membrane assembly, gephyrin and PSD-95 clustering, and positive regulation of excitatory postsynaptic potential indicate a cohesive module centered on synapse organization at excitatory synapses.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097104","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0097116","count":2},{"id":"GO:2000463","count":2},{"id":"GO:0097119","count":2}]},{"hash":"722160659575573269","title":"Antiviral cytotoxic immune signaling and ubiquitination","description":"The top GO terms point to cytotoxic immune activity (granzyme-mediated apoptotic signaling), defense against viruses (defense response to virus) and interferon signaling, along with ubiquitin-related regulation (protein autoubiquitination). While a couple of terms (histone modification, sex differentiation) noise the signal, the core cluster coherently maps to antiviral immune responses and their regulation via ubiquitin pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008626","count":2},{"id":"GO:0006463","count":2},{"id":"GO:0030579","count":2},{"id":"GO:0016570","count":2},{"id":"GO:0050689","count":2}]},{"hash":"149621347035266019","title":"Ubiquitin-Mediated TNF/NF-\u03baB Signaling","description":"The top GO terms center on ubiquitination (autoubiquitination, K6-linked ubiquitin) and regulation of inflammatory signaling, including TNF signaling and I-\u03baB phosphorylation, as well as apoptosis. Although a few terms relate to chromatin or immune processes, the dominant theme is ubiquitin-dependent control of inflammatory signaling and cell fate.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901253","count":3},{"id":"GO:0033151","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0009048","count":3}]},{"hash":"1413253065563453414","title":"PI3K/AKT signaling in immune development and remodeling","description":"This cluster centers on PI3K/AKT pathway signaling (GO:0043491) and includes immune differentiation terms (B cell, CD8+ T cell differentiation) along with development and remodeling processes (bone resorption, mammary gland proliferation, lung morphogenesis-related branching, endothelial proliferation) and metabolic aspects (triglyceride storage). The common thread appears to be a PI3K/AKT\u2013driven signaling paradigm that influences proliferation, differentiation, and tissue remodeling across immune and non-immune contexts, with metabolic links. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043491","count":3},{"id":"GO:0035509","count":2},{"id":"GO:0030183","count":2},{"id":"GO:0030730","count":2},{"id":"GO:0043374","count":2}]},{"hash":"1093363203865385516","title":"Multitissue Development and Cell Adhesion","description":"This cluster centers on developmental processes across several tissues (immune, neural, kidney, ureter, vasculature) and includes motifs of cell adhesion and polarity (homophilic and calcium-dependent adhesion, apical localization). While no single pathway dominates, the shared themes are tissue differentiation and morphogenesis with an emphasis on how cells stick together and organize polarity during development, making this a coherent, high-level label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002314","count":3},{"id":"GO:0097118","count":3},{"id":"GO:0060019","count":3},{"id":"GO:0072006","count":3},{"id":"GO:0045176","count":3}]},{"hash":"1433084900122847437","title":"Unknown","description":"The top GO terms span immune cell differentiation, tissue development/proliferation, metabolism, and bone remodeling, with no single cohesive function linking them. Given the small cluster and diverse terms, a specific, representative label isn\u2019t supported.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035509","count":1},{"id":"GO:0030183","count":1},{"id":"GO:0030730","count":1},{"id":"GO:0043374","count":1},{"id":"GO:0071230","count":1}]},{"hash":"879385585498772100","title":"RNA and protein methylation","description":"Top terms are dominated by methylation-related processes, including rRNA methylation, peptidyl-lysine methylation, and N-terminal methylation, suggesting a cohesive theme of methylation-based RNA and protein modifications. Some metabolic terms appear but likely contribute noise rather than core function. This makes the label a reasonably representative summary of the cluster\u2019s biology.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":1},{"id":"GO:0008203","count":1},{"id":"GO:0046188","count":1},{"id":"GO:0019285","count":1},{"id":"GO:0015945","count":1}]},{"hash":"999598638903341929","title":"Dopaminergic Signaling and Eating Behavior","description":"The cluster is dominated by GO terms related to dopaminergic synaptic transmission (GO:0001963), sensitization (GO:0046960), and eating behavior (GO:0042755), plus a GPCR-cGMP signaling connection (GO:0007199). This points to a theme of dopamine-driven neural signaling involved in reward and feeding behavior. Some terms (defense response to bacterium, vascular permeability) may reflect broader GPCR usage or incidental associations rather than core function, so the central interpretation centers on dopaminergic signaling in feeding-related neural circuits.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046960","count":3},{"id":"GO:0042755","count":3},{"id":"GO:0001963","count":3},{"id":"GO:0007199","count":3},{"id":"GO:1900134","count":3}]},{"hash":"2031907831756354629","title":"Neural cell adhesion and migration","description":"The top GO terms cluster around cell-cell adhesion and localization to cell junctions, with neural development signals such as motor neuron axon guidance and neuron migration. Immune-regulatory terms are also present, suggesting additional roles in modulating immune responses. Overall, the dominant theme is neural cell adhesion and development, with potential secondary immune regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":2},{"id":"GO:0046814","count":2},{"id":"GO:0008045","count":2},{"id":"GO:0042271","count":2},{"id":"GO:1902414","count":2}]},{"hash":"1474447223875303539","title":"Zinc ion homeostasis and detoxification","description":"The top GO terms show repeated emphasis on zinc biology\u2014intracellular zinc ion homeostasis, detoxification of zinc ion, and related regulation of zinc transport\u2014suggesting a central theme around zinc ion regulation. While several other terms (e.g., chitin catabolic process, production of molecular mediators involved in inflammatory response) are present, they are less cohesive with the zinc-centered terms, which may reflect annotation noise or multifunctionality. Given the small cluster size and lack of detected interactions, this label best captures the core theme with cautious (Low) confidence.","confidence":"Low","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":1},{"id":"GO:0006032","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0061090","count":1}]},{"hash":"1403104376872045616","title":"Embryonic morphogenesis and axon guidance","description":"The top GO terms cluster around developmental morphogenesis across organs (kidney nephrogenesis, coronary artery and dorsal aorta morphogenesis) and neural wiring (axon extension/guidance), with supporting roles in cell-matrix adhesion and Hedgehog pathway regulation. This points to proteins involved in embryonic tissue patterning and connectivity rather than a single, narrow function; the complement activation term appears incidental. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0072218","count":3},{"id":"GO:0060982","count":2},{"id":"GO:0072221","count":2},{"id":"GO:0045880","count":2}]},{"hash":"201852285629950466","title":"Taste Perception and GPCR Signaling","description":"This cluster is dominated by terms related to sweet taste detection and GPCR-mediated signaling (e.g., GO:0001582, GO:0007196, GO:0007206) and includes sensory-behavior connections like conditioned taste aversion, suggesting a common function in taste perception and its signaling pathways. The defense-related terms appear less connected and may reflect broad annotations or multifunctional proteins. Overall, the proteins seem linked to taste signaling and associated sensory behavior.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001582","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0007196","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0007206","count":3}]},{"hash":"1722291378984159190","title":"Neuronal development and synaptic regulation","description":"The top GO terms show strong emphasis on regulation of synaptic vesicle exocytosis and endocytosis, along with negative regulation of dendrite morphogenesis, which points to neuronal development and synaptic function. Additional terms like retina layer formation and detection of stimulus involved in sensory perception further tie the cluster to sensory neuron/visual system development, supporting a cohesive theme of neuronal development and synaptic regulation. Some terms (protein methylation, hydrogen peroxide biosynthesis) are broader cellular processes that can appear in multiple cell types, but the dominant signal here supports a neuronal/sensory development interpretation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006479","count":3},{"id":"GO:1900242","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0050774","count":3},{"id":"GO:0035191","count":3}]},{"hash":"1420846331684715106","title":"Apoptosis and Ras signaling regulation","description":"This cluster\u2019s top terms cluster around negative regulation of proteasomal protein degradation and negative regulation of Ras signaling, along with the apoptotic process. Together these suggest a core theme of modulating cell survival and signaling pathways, even though some additional terms (like dendrite morphogenesis and immune-related processes) appear less central. The label captures the strongest, coherent function motifs in this small cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0048813","count":1},{"id":"GO:1990804","count":1}]},{"hash":"410801151393235623","title":"Negative Regulation of Cellular Functions","description":"The top GO terms are dominated by negative regulation across diverse processes\u2014bone development, protein kinase activity, calcium-dependent ATPase activity, DNA catabolic process, cyclic-nucleotide phosphodiesterase activity, lipoprotein oxidation, and responses to nutrients and fatty acids\u2014suggesting the cluster reflects inhibitory control over multiple cellular pathways rather than a single pathway. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903011","count":1},{"id":"GO:0046470","count":1},{"id":"GO:0006469","count":1},{"id":"GO:1903611","count":1},{"id":"GO:0034445","count":1}]},{"hash":"1115523580190464789","title":"Neuronal Synaptic Regulation and Development","description":"This cluster centers on neural development and synaptic function, with terms for regulation of synaptic vesicle endocytosis and exocytosis, dendrite morphogenesis, astrocyte development, and retina layer formation, suggesting a module tied to neural/retinal development and synaptic regulation. Some terms (hypoxia response, methylation, oxidative processes, cuticle development) appear peripheral and do not define the core function.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":1},{"id":"GO:0071456","count":1},{"id":"GO:0006479","count":1},{"id":"GO:2001015","count":1},{"id":"GO:2000300","count":1}]},{"hash":"1282056371754688788","title":"Nuclear RNA processing and telomere maintenance","description":"The top GO terms are dominated by mRNA processing (2) and telomere-related processes (telomere maintenance via telomerase and localization to telomeric regions), which point to a nuclear function combining RNA processing with chromosomal telomere regulation. Other terms appear more as noise or broad cellular processes rather than a cohesive theme. Confidence in this label is Medium.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0032212","count":1},{"id":"GO:0070198","count":1},{"id":"GO:0086070","count":1},{"id":"GO:0007253","count":1}]},{"hash":"66387434388213615","title":"Metal ion transport and immune signaling","description":"The top GO terms point to metal ion transport (aluminum, iron, manganese, cadmium, nitrite) and immune-related functions (TH1 regulation, dendritic cell antigen presentation, respiratory burst, IL-3 production). This suggests the proteins in this cluster may link metal ion homeostasis with immune activation, or at least share dual roles in transport and immune signaling; the lack of observed edges indicates the clustering is driven by GO associations rather than direct protein-protein interactions in this dataset.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015690","count":1},{"id":"GO:0002827","count":1},{"id":"GO:0006876","count":1},{"id":"GO:0045730","count":1},{"id":"GO:0002606","count":1}]},{"hash":"1920634721356683600","title":"Inhibition of neutrophil activation","description":"Based on the top GO term GO:1902564, which denotes negative regulation of neutrophil activation, the cluster appears to group proteins involved in dampening neutrophil responses. With only this single function highlighted and a small network, the label \u201cInhibition of neutrophil activation\u201d is the most representative and specific.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902564","count":1}]},{"hash":"1510753774987883838","title":"Glycosaminoglycan biosynthesis","description":"The GO terms cluster around synthesis and modification of proteoglycans and their glycosaminoglycan (GAG) chains\u2014keratan sulfate and heparin proteoglycan biosynthesis, along with N-acetylglucosamine metabolism and sulfation-related processes\u2014suggesting a core function in GAG/proteoglycan biosynthesis. Other terms indicate broader metabolic roles (xenobiotic, thyroid hormone, estrogen metabolism) that are less specific to this cluster, so the dominant signal points to GAG biosynthesis. With three proteins, the link is present but not extensive, hence a cautious but reasonable label. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002002","count":2},{"id":"GO:0006711","count":2},{"id":"GO:0018146","count":2},{"id":"GO:0006044","count":2},{"id":"GO:0030205","count":2}]},{"hash":"1966237919093903616","title":"Zinc Ion Transport and Homeostasis","description":"The top GO terms cluster around zinc handling: zinc ion import across the plasma membrane, intracellular zinc ion homeostasis, detoxification of zinc ion, and responses related to zinc starvation, plus related metal transport such as cadmium. This strongly suggests a function in zinc uptake and maintenance of cellular zinc balance, with the other terms likely representing peripheral or unrelated annotations. Confidence: High","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903615","count":1},{"id":"GO:0006831","count":1},{"id":"GO:0044749","count":1},{"id":"GO:0010312","count":1},{"id":"GO:0006830","count":1}]},{"hash":"1875942754472104958","title":"Vertebrate Organogenesis and Patterning","description":"The top terms cluster around the development and morphogenesis of multiple vertebrate organs (pituitary and pineal glands, heart/pericardium, kidney/renal system) and left/right body patterning, suggesting a broad focus on vertebrate organogenesis rather than a single molecular activity; occasional transcription-related terms may reflect general gene expression activity in developmental contexts.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042796","count":1},{"id":"GO:0042795","count":1},{"id":"GO:0021983","count":1},{"id":"GO:0035462","count":1},{"id":"GO:0003344","count":1}]},{"hash":"2211001151711040339","title":"Immune Response Cluster","description":"Based on the GO terms, there is a strong signal for immune function\u2014innate and adaptive immune responses and antibacterial humoral response, along with regulation of respiratory burst\u2014suggesting the proteins in this cluster are primarily involved in immune defense. A few terms (retina homeostasis, glomerular filtration, telomere maintenance) appear unrelated, but the dominant theme is immunity. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":1},{"id":"GO:0060267","count":1},{"id":"GO:0003094","count":1},{"id":"GO:0032461","count":1},{"id":"GO:0002250","count":1}]}]