{"hash":"132782780089205782","title":"Extracellular matrix remodeling and bone resorption","description":"The top GO terms point to breakdown and remodeling of extracellular matrix components: basement membrane disassembly, collagen catabolic process, and bone resorption, with related tissue remodeling processes like decidualization and bradykinin catabolic activity. While there are broader regulatory or signaling terms present (e.g., regulation of catalytic activity, Wnt-related notes, thyroid hormone response), the strongest and most coherent signal across the terms is ECM degradation/remodeling, suggesting these proteins function together in ECM remodeling and bone/tissue turnover. Confidence: Medium","confidence":"","size":20,"edges":68,"triangles":149,"max_degree":19,"top_function":null,"members":[{"accession":"XP_071825262.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"XP_071825579.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_071832637.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0018149","GO:0002839","GO:0060009","GO:2000504","GO:0008584","GO:0042747","GO:0030502","GO:0050766","GO:0032355","GO:0008544","GO:0007431","GO:0001666","GO:0009636","GO:0008344","GO:0033629","GO:0043067","GO:0045740","GO:0008284","GO:0030216","GO:0060548","GO:0070301","GO:0070268","GO:0048678","GO:0006953","GO:0001654","GO:0060311","GO:0060313","GO:0010951","GO:2001027","GO:0009743","GO:0010593","GO:0007420","GO:0010716","GO:0007566","GO:0042493","GO:0031667","GO:0010711","GO:1900747","GO:0006915","GO:0007339","GO:0030195","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_071852496.1","go_terms":["GO:0097067","GO:0050790","GO:0030574","GO:0006508","GO:0046697","GO:0051603","GO:0001957","GO:0010815","GO:0010813","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0045453","GO:0035593"]},{"accession":"XP_071854734.1","go_terms":["GO:0097067","GO:0050790","GO:0030574","GO:0006508","GO:0046697","GO:0051603","GO:0001957","GO:0010815","GO:0010813","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0045453","GO:0035593"]},{"accession":"XP_071819840.1","go_terms":["GO:0051603","GO:0050790","GO:0097067","GO:0001957","GO:0010815","GO:0010813","GO:0030574","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0046697","GO:0045453","GO:0035593"]},{"accession":"XP_071825259.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"XP_071835840.1","go_terms":["GO:0051603","GO:0050790","GO:0097067","GO:0001957","GO:0010815","GO:0010813","GO:0030574","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0046697","GO:0045453","GO:0035593"]},{"accession":"XP_071836322.1","go_terms":["GO:0051603","GO:0050790","GO:0097067","GO:0001957","GO:0010815","GO:0010813","GO:0030574","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0046697","GO:0045453","GO:0035593"]},{"accession":"XP_071846541.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_071854730.1","go_terms":["GO:0097067","GO:0050790","GO:0030574","GO:0006508","GO:0046697","GO:0051603","GO:0001957","GO:0010815","GO:0010813","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0045453","GO:0035593"]},{"accession":"XP_071830927.1","go_terms":[]},{"accession":"XP_071847115.1","go_terms":["GO:0035017","GO:0007286","GO:1903045","GO:0030035","GO:0007043","GO:0035317","GO:0042462","GO:0071803","GO:0035089","GO:0008407","GO:0051491","GO:0048800","GO:0090091","GO:0030034","GO:0032956","GO:0035099","GO:0010592","GO:1900107","GO:0032534","GO:0070511"]},{"accession":"XP_071820443.1","go_terms":["GO:0009718","GO:0001081","GO:0009242","GO:0006541","GO:0006012","GO:0006351","GO:1901006","GO:0009699","GO:0055114","GO:1902128","GO:1902129","GO:1902138","GO:1902125","GO:1902135","GO:1902132","GO:1902123","GO:1902131","GO:0019673","GO:0009243","GO:0009244","GO:0009103","GO:0080110","GO:0042619","GO:0042351","GO:0097171","GO:0019305","GO:0035754","GO:0060716","GO:0001942","GO:0016126","GO:0008204","GO:1902653"]},{"accession":"XP_071817230.1","go_terms":[]},{"accession":"XP_071826223.1","go_terms":["GO:0015701","GO:0038166","GO:0006730","GO:0032849","GO:2001150","GO:0010043","GO:0032230","GO:0002009","GO:0045780","GO:0001580","GO:0001822","GO:2001225","GO:0015670","GO:0071498","GO:0055064","GO:0043627","GO:0009268","GO:0046903","GO:0042475","GO:0045672","GO:0070445","GO:0048545"]},{"accession":"XP_071852011.1","go_terms":["GO:0000002","GO:0030150","GO:0045039","GO:0032094","GO:0045037"]},{"accession":"XP_071848455.1","go_terms":[]},{"accession":"XP_071846637.1","go_terms":["GO:0009831","GO:0042546","GO:0031505","GO:0032491","GO:0010411","GO:0006037"]},{"accession":"XP_071842765.1","go_terms":["GO:0007219","GO:0034205","GO:0006509","GO:0007220","GO:0031293","GO:0060465"]}],"graph":[["XP_071819840.1","XP_071817230.1",0.652],["XP_071819840.1","XP_071820443.1",0.641],["XP_071819840.1","XP_071825259.1",0.942],["XP_071819840.1","XP_071825262.1",0.869],["XP_071819840.1","XP_071825579.1",0.874],["XP_071819840.1","XP_071836322.1",0.678],["XP_071819840.1","XP_071835840.1",0.605],["XP_071819840.1","XP_071832637.1",0.921],["XP_071819840.1","XP_071830927.1",0.544],["XP_071819840.1","XP_071826223.1",0.644],["XP_071819840.1","XP_071854730.1",0.831],["XP_071819840.1","XP_071854734.1",0.826],["XP_071819840.1","XP_071852011.1",0.675],["XP_071819840.1","XP_071852496.1",0.851],["XP_071819840.1","XP_071848455.1",0.536],["XP_071819840.1","XP_071846637.1",0.541],["XP_071819840.1","XP_071847115.1",0.624],["XP_071819840.1","XP_071846541.1",0.823],["XP_071819840.1","XP_071842765.1",0.811],["XP_071836322.1","XP_071825259.1",0.822],["XP_071836322.1","XP_071825262.1",0.817],["XP_071836322.1","XP_071825579.1",0.676],["XP_071836322.1","XP_071832637.1",0.686],["XP_071836322.1","XP_071852496.1",0.662],["XP_071836322.1","XP_071854730.1",0.519],["XP_071836322.1","XP_071854734.1",0.547],["XP_071817230.1","XP_071846541.1",0.695],["XP_071817230.1","XP_071852496.1",0.705],["XP_071825262.1","XP_071825259.1",0.805],["XP_071825262.1","XP_071825579.1",0.832],["XP_071825262.1","XP_071832637.1",0.88],["XP_071825262.1","XP_071835840.1",0.871],["XP_071825262.1","XP_071846541.1",0.849],["XP_071825262.1","XP_071852496.1",0.928],["XP_071825262.1","XP_071854730.1",0.834],["XP_071825262.1","XP_071854734.1",0.705],["XP_071832637.1","XP_071825259.1",0.845],["XP_071832637.1","XP_071825579.1",0.668],["XP_071832637.1","XP_071835840.1",0.815],["XP_071832637.1","XP_071846541.1",0.789],["XP_071832637.1","XP_071852496.1",0.802],["XP_071832637.1","XP_071854730.1",0.714],["XP_071832637.1","XP_071854734.1",0.71],["XP_071852496.1","XP_071820443.1",0.561],["XP_071852496.1","XP_071825259.1",0.788],["XP_071852496.1","XP_071825579.1",0.837],["XP_071852496.1","XP_071826223.1",0.522],["XP_071852496.1","XP_071835840.1",0.606],["XP_071852496.1","XP_071842765.1",0.504],["XP_071852496.1","XP_071846541.1",0.89],["XP_071852496.1","XP_071854730.1",0.859],["XP_071852496.1","XP_071854734.1",0.7],["XP_071825259.1","XP_071825579.1",0.742],["XP_071825259.1","XP_071835840.1",0.649],["XP_071825259.1","XP_071846541.1",0.785],["XP_071825259.1","XP_071854730.1",0.693],["XP_071825259.1","XP_071854734.1",0.783],["XP_071854730.1","XP_071825579.1",0.746],["XP_071854730.1","XP_071835840.1",0.68],["XP_071854730.1","XP_071846541.1",0.816],["XP_071854730.1","XP_071854734.1",0.741],["XP_071854734.1","XP_071825579.1",0.8],["XP_071854734.1","XP_071835840.1",0.589],["XP_071854734.1","XP_071842765.1",0.62],["XP_071854734.1","XP_071846541.1",0.769],["XP_071846541.1","XP_071825579.1",0.805],["XP_071846541.1","XP_071852011.1",0.76],["XP_071835840.1","XP_071825579.1",0.599]],"all_go_terms":{"GO:0050790":11,"GO:0001913":11,"GO:0034769":11,"GO:1903955":5,"GO:0030574":11,"GO:0035593":11,"GO:0051603":11,"GO:0097067":11,"GO:0045453":11,"GO:0043129":5,"GO:0046697":11,"GO:0071888":5,"GO:0007614":5,"GO:0010815":11,"GO:2000179":11,"GO:0010839":5,"GO:1903146":5,"GO:0060448":11,"GO:0060441":11,"GO:0010813":11,"GO:0001957":11,"GO:0043418":3,"GO:0009636":3,"GO:0042493":3,"GO:1990236":3,"GO:1990237":3,"GO:0006508":6,"GO:0006915":1,"GO:0060311":1,"GO:0070301":1,"GO:0060548":1,"GO:0006953":1,"GO:0032355":1,"GO:0031667":1,"GO:0008584":1,"GO:0070268":1,"GO:0001666":1,"GO:2001027":1,"GO:0030195":1,"GO:0048678":1,"GO:0050766":1,"GO:0001654":1,"GO:0010716":1,"GO:0002839":1,"GO:0007566":1,"GO:0033629":1,"GO:0007339":1,"GO:0018149":1,"GO:0043067":1,"GO:0030216":1,"GO:0008344":1,"GO:0030502":1,"GO:0009743":1,"GO:0008544":1,"GO:0060009":1,"GO:0010593":1,"GO:0010951":1,"GO:0007420":1,"GO:0045740":1,"GO:1900747":1,"GO:0010711":1,"GO:0042747":1,"GO:0008284":1,"GO:2000504":1,"GO:0007431":1,"GO:0060313":1,"GO:0008407":1,"GO:0030034":1,"GO:0035017":1,"GO:0071803":1,"GO:0051491":1,"GO:0048800":1,"GO:0032956":1,"GO:1903045":1,"GO:0007286":1,"GO:1900107":1,"GO:0070511":1,"GO:0010592":1,"GO:0032534":1,"GO:0042462":1,"GO:0007043":1,"GO:0090091":1,"GO:0035099":1,"GO:0035317":1,"GO:0035089":1,"GO:0030035":1,"GO:0009699":1,"GO:0006351":1,"GO:0009242":1,"GO:1902125":1,"GO:0009718":1,"GO:0001081":1,"GO:0055114":1,"GO:1901006":1,"GO:0035754":1,"GO:1902123":1,"GO:0042351":1,"GO:1902135":1,"GO:1902138":1,"GO:0019673":1,"GO:0009244":1,"GO:0009103":1,"GO:0019305":1,"GO:1902129":1,"GO:1902131":1,"GO:0009243":1,"GO:0006012":1,"GO:1902128":1,"GO:0097171":1,"GO:0001942":1,"GO:1902653":1,"GO:0016126":1,"GO:0060716":1,"GO:0080110":1,"GO:1902132":1,"GO:0006541":1,"GO:0042619":1,"GO:0008204":1,"GO:0042475":1,"GO:0045780":1,"GO:0071498":1,"GO:0009268":1,"GO:0006730":1,"GO:0032849":1,"GO:0015701":1,"GO:2001150":1,"GO:0002009":1,"GO:0015670":1,"GO:0055064":1,"GO:0046903":1,"GO:0070445":1,"GO:0010043":1,"GO:0001580":1,"GO:0032230":1,"GO:0045672":1,"GO:0048545":1,"GO:2001225":1,"GO:0001822":1,"GO:0043627":1,"GO:0038166":1,"GO:0045039":1,"GO:0030150":1,"GO:0000002":1,"GO:0045037":1,"GO:0032094":1,"GO:0032491":1,"GO:0031505":1,"GO:0009831":1,"GO:0010411":1,"GO:0042546":1,"GO:0006037":1,"GO:0031293":1,"GO:0006509":1,"GO:0034205":1,"GO:0007220":1,"GO:0007219":1,"GO:0060465":1},"recipe_readded":[]}