[{"hash":"584005895222478867","title":"Sterol metabolism and SREBP signaling","description":"The top GO terms are strongly centered on cholesterol biosynthesis and SREBP signaling (GO:0032933, GO:0006695), with additional related processes like cholesterol efflux and DNA-templated transcription, suggesting a core function in lipid metabolism coupled to transcriptional regulation. Other development and signaling terms (pharyngeal system development, Smoothened pathway, epidermal cell fate) indicate broader regulatory roles that may intersect lipid signaling with developmental pathways. Overall, the cluster appears best described by sterol metabolism and SREBP-driven transcriptional signaling, with a developmental signaling context.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032933","count":6},{"id":"GO:0060037","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0006695","count":5},{"id":"GO:0008542","count":5}]},{"hash":"1459794260902251402","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":7,"triangles":0,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0000447","count":6},{"id":"GO:0000480","count":6},{"id":"GO:0042273","count":6}]},{"hash":"17906649876785190","title":"TGF-\u03b2\u2013Mediated Morphogenesis and Cell Migration","description":"Top GO terms indicate a focus on cytoskeletal remodeling and migratory processes (lamellipodium morphogenesis, smooth muscle cell migration), coupled with positive regulation of tyrosine phosphorylation and GTPase activity, within a TGF-\u03b2\u2013responsive signaling context. The inclusion of development-related terms (bone, uterus) and endocytosis/apoptosis suggests broader morphogenesis and trafficking roles, supporting a cohesive theme of TGF-\u03b2\u2013driven morphogenesis and cell movement.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050731","count":5},{"id":"GO:2000394","count":4},{"id":"GO:0014911","count":4},{"id":"GO:0060065","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1873399046007976842","title":"Lipid and sugar metabolism with nitrosative stress response","description":"The cluster is dominated by fatty acid biosynthesis and several sugar (sorbitol/xylitol) catabolic pathways, with a notable nitrosative stress response term, suggesting a metabolism- and stress-adaptation-focused group. Some obsolete or animal-specific terms appear, but the core signal points to lipid and carbohydrate metabolism and associated stress responses.","confidence":"Medium","size":29,"edges":398,"triangles":3454,"max_degree":28,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006633","count":14},{"id":"GO:0055114","count":9},{"id":"GO:0051160","count":7},{"id":"GO:0003016","count":7},{"id":"GO:0051409","count":7}]},{"hash":"132216993751975644","title":"Translation initiation and reinitiation (viral IRES)","description":"The top GO terms are centered on translation initiation and reinitiation, including translation reinitiation, formation of the translation preinitiation complex, and regulation of translational initiation, plus viral IRES-dependent initiation and related reinitiation/termination mechanisms. A few unrelated terms appear (proliferation, meiosis cohesion, development, sensory functions), but the clearest and strongest signal is translational control, suggesting the cluster largely comprises proteins involved in initiating translation. Confidence: High","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006446","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0075522","count":2}]},{"hash":"361069493924239198","title":"Developmental gene regulation and neural signaling","description":"The cluster\u2019s top terms point to transcriptional control and chromatin dynamics (DNA-templated transcription, DNA replication, subtelomeric heterochromatin formation) alongside development and growth processes (angiogenesis, multicellular organism development, visual learning) and neural function (excitatory postsynaptic potential). This suggests a cohesive theme around gene regulation during development with neural signaling, though a few terms (ectoine transport, cell wall organization) may be peripheral or annotation artifacts. The sparse connections (low edge count) advise a cautious, representative label rather than a tightly defined pathway.","confidence":"Medium","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0046826","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1070111205531445670","title":"Splicing Regulation and mRNA Stability","description":"The top terms are dominated by spliceosome-related processes (mRNA splicing via spliceosome; regulation of alternative mRNA splicing) and mRNA stability in response to stress, with additional signals pointing to translational control and broader cell-cycle signaling. This indicates the cluster groups proteins involved in post-transcriptional gene regulation, primarily splicing regulation and stress-responsive mRNA stability.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:2000766","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0010610","count":3}]},{"hash":"866296716607868559","title":"Neural development and axon guidance","description":"The top GO terms are dominated by nervous system development, axon guidance, Roundabout signaling, synapse assembly regulation, myelination, and cell adhesion, which collectively point to proteins involved in neural development and neurite pathfinding. Although a single term related to symbiont entry appears among the list, the overall pattern strongly supports roles in neural patterning, connectivity, and insulation rather than immune or host-entry processes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090197","count":10},{"id":"GO:0002374","count":10},{"id":"GO:0035385","count":10},{"id":"GO:0007411","count":10},{"id":"GO:0007399","count":10}]},{"hash":"543344700826355941","title":"Immune regulation and cytotoxic signaling","description":"The proteins cluster around immune signaling and regulatory processes, with GO terms for CD40 signaling, Fc receptor signaling, T cell activation and its negative regulation, NK and macrophage activation regulation, and phagocytosis, suggesting a theme of controlling immune cell activation and cytotoxic responses; mitophagy and ER membrane fusion may reflect stress responses in immune cells. Overall, they point to a coordinated immune-regulatory function rather than a single enzymatic pathway.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0000422","count":3},{"id":"GO:0016320","count":3},{"id":"GO:2000350","count":3},{"id":"GO:0060370","count":3}]},{"hash":"294360827807571135","title":"Neural development and cell adhesion","description":"The top GO terms point strongly to neural development (nervous system development, neurogenesis, peripheral nervous system development) together with cell adhesion (homophilic cell-cell adhesion, cell adhesion). The presence of Roundabout signaling further supports axon guidance and neuronal migration. Some immune-related terms appear but seem secondary to the main neural-development and adhesion theme, suggesting the cluster centers on neurodevelopmental processes and cell-contact signaling rather than immune function. Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0045663","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007155","count":3}]},{"hash":"272012486281116007","title":"Actin Cytoskeleton Remodeling and Cell Adhesion","description":"This cluster is dominated by GO terms tied to actin dynamics (crosslinking, cortical localization, microspike assembly), cell adhesion, and polarity/shape maintenance, with supporting signals from exocytosis and Rho signaling, pointing to cortex-centric actin remodeling that governs adhesion and cell morphology. The IL-2 production term is a secondary cue, likely reflecting immune-related signaling that interfaces with the cytoskeleton.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0051764","count":2},{"id":"GO:0071963","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0006887","count":2}]},{"hash":"416986424513560775","title":"Hemostasis and inflammatory signaling","description":"This cluster's GO terms cluster around blood coagulation (fibrin clot formation), complement activation, and inflammatory signaling (IL-1 response), with additional links to platelet regulation and cell adhesion. While there are some unrelated terms (UV-B response, NMJ axon regeneration), the dominant theme is coagulation together with innate immune signaling, supporting a cohesive interpretation as a hemostasis-immune cluster.","confidence":"Medium","size":29,"edges":44,"triangles":10,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072378","count":6},{"id":"GO:0001867","count":5},{"id":"GO:0071347","count":5},{"id":"GO:0071493","count":5},{"id":"GO:0014814","count":5}]},{"hash":"2111004969813336138","title":"Extrinsic apoptosis and inflammatory signaling modulators","description":"This cluster is dominated by GO terms involving regulation of the extrinsic apoptotic pathway (death receptor\u2013mediated) and inflammatory signaling (NF-kappaB, TNF, IL-17, LPS), plus related inflammatory responses. The combination suggests a group of proteins that fine-tune both apoptosis and immune/inflammatory signaling rather than executing these processes directly.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:2001241","count":6},{"id":"GO:2000002","count":5},{"id":"GO:0050728","count":5},{"id":"GO:1902043","count":4},{"id":"GO:0006954","count":4}]},{"hash":"1164738230891165969","title":"Cell Proliferation and Synaptic Signaling Regulation","description":"GO terms show strong signals for cell cycle and division (cell cycle, cell division) and ERK-related signaling, alongside neural synaptic processes (dopamine uptake, synaptic vesicle exocytosis). The mix suggests a cluster where growth/proliferation signaling intersects with synaptic regulation, rather than a single pure pathway. Therefore, the label reflects both themes: cell proliferation signaling and neural synaptic regulation.","confidence":"Medium","size":29,"edges":8,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007049","count":13},{"id":"GO:0070374","count":11},{"id":"GO:0051586","count":10},{"id":"GO:0008283","count":10},{"id":"GO:0010513","count":10}]},{"hash":"1960019444659302298","title":"Axon Guidance and Neural Crest Migration","description":"The top terms cluster around neural development, especially axon guidance, neuron projection, synapse assembly, and neural crest\u2013derived cell migration. Semaphorin-plexin signaling, trigeminal nerve organization, sympathetic neuron guidance, branchiomotor axon guidance, and ventral trunk neural crest migration all point to coordinated neural wiring and cranial/cardiovascular neural crest\u2013related development. This suggests proteins functioning in neuronal pathfinding and neural crest\u2013driven tissue patterning.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":12},{"id":"GO:0051965","count":10},{"id":"GO:0007413","count":10},{"id":"GO:0021637","count":10},{"id":"GO:0097491","count":10}]},{"hash":"232750986044085637","title":"Embryonic Eye and Retina Development","description":"The cluster is dominated by terms tied to eye and retina formation during embryogenesis (embryonic eye morphogenesis, in utero embryonic development, camera-type eye development, retina development in camera-type eye). There is also enrichment for transcriptional regulation by RNA polymerase II, indicating coordinated gene expression during this developmental process. While other terms touch broader organ development (placenta, pituitary), the strongest theme is eye/retina development in the embryo, making this label representative.","confidence":"High","size":29,"edges":197,"triangles":420,"max_degree":22,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":12},{"id":"GO:0001701","count":11},{"id":"GO:0006366","count":11},{"id":"GO:0021983","count":11},{"id":"GO:0060441","count":10}]},{"hash":"1902669536866530948","title":"Vascular ECM Remodeling and Coagulation","description":"This cluster is dominated by GO terms for collagen fibril organization, cell\u2013matrix adhesion, angiogenesis regulation, platelet activation, and blood coagulation, indicating extracellular matrix remodeling and hemostasis within a vascular context. Additional terms for complement activation, IL-1 response, and ERK signaling suggest accompanying immune and inflammatory signaling during vascular remodeling or injury. Together, they define a cohesive vascular ECM/coagulation theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":11},{"id":"GO:0016525","count":11},{"id":"GO:0001867","count":8},{"id":"GO:0030168","count":8},{"id":"GO:0007160","count":8}]},{"hash":"1287757032539033811","title":"Vascular adhesion and coagulation regulation","description":"The cluster is enriched for adhesion terms (heterophilic cell-cell and cell-matrix adhesion) and migration in sprouting angiogenesis, together with coagulation and plasminogen activation terms (blood coagulation, plasminogen activation, Factor XII activation, regulation of circulating fibrinogen). This points to a cohesive theme of vascular remodeling involving adhesion, migration, and coagulation/fibrinolysis processes, supporting a label that reflects both vascular adhesion and coagulation regulation.","confidence":"High","size":29,"edges":4,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":24},{"id":"GO:0007160","count":23},{"id":"GO:0090050","count":22},{"id":"GO:0030194","count":19},{"id":"GO:0014909","count":19}]},{"hash":"2033633009993882705","title":"GPCR-cAMP signaling in blood pressure regulation","description":"The top GO terms cluster around activation of adenylate cyclase and GPCR signaling, including the adenylate cyclase-activating GPCR pathway and norepinephrine/vasoconstriction involved in regulating systemic blood pressure, as well as positive regulation of blood pressure and related renal sodium excretion. This points to a cohesive theme of catecholamine-driven cardiovascular signaling and blood pressure homeostasis, with other terms like immune response or bone remodeling likely reflecting broader cellular roles. Overall, the dominant signal supports a cardiovascular signaling function.","confidence":"Medium","size":29,"edges":6,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":25},{"id":"GO:0007190","count":25},{"id":"GO:0010579","count":25},{"id":"GO:0022900","count":25},{"id":"GO:0006955","count":24}]},{"hash":"704118814309544432","title":"Coagulation and Angiogenesis Regulators","description":"The top GO terms are dominated by coagulation-related processes (complement activation via the lectin pathway, plasminogen activation, and fibrinolysis) and positive regulation of angiogenesis, indicating a cluster of proteins involved in vascular remodeling and extracellular proteolysis. Additional terms point to signaling via receptor tyrosine kinases and leptin-responsive pathways, suggesting coordinated extracellular signaling that influences blood vessel growth and tissue remodeling. Some terms about osteoblast proliferation and adhesion are present but do not outweigh the clear vascular/coagulation theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001867","count":12},{"id":"GO:0031639","count":12},{"id":"GO:0045766","count":12},{"id":"GO:0007171","count":12},{"id":"GO:0042730","count":12}]},{"hash":"1910090820356451091","title":"Unknown","description":"The top GO terms are broad and scattered across neuronal development (paranode localization, synapse and dendrite regulation), early development (axial mesoderm formation, ovulation cycle), immune signaling (T cell costimulation, lymphangiogenesis), and even an obsolete transport term, with no clear, single function tying all proteins together. This makes a specific, representative label difficult.","confidence":"","size":29,"edges":405,"triangles":3627,"max_degree":28,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0002175","count":20},{"id":"GO:0006032","count":19},{"id":"GO:0045663","count":19},{"id":"GO:0042698","count":19},{"id":"GO:0048320","count":19}]},{"hash":"1883845415101727902","title":"Adrenergic Cardiovascular Regulation","description":"The cluster is dominated by GO terms tied to sympathetic signaling and cardiovascular control, including positive regulation of blood pressure, norepinephrine/epinephrine\u2013mediated vasoconstriction, heart rate regulation, and GPCR-cAMP signaling activating adenylyl cyclase, plus renal sodium excretion. Some terms like nipple morphogenesis or operant conditioning appear unrelated and likely noise, while electron transport chain reflects general cellular energy needs rather than a core function. Overall, the proteins appear to function in adrenergic regulation of vascular tone, cardiac activity, and renal sodium handling that together modulate blood pressure.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":26},{"id":"GO:0010579","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0035025","count":25},{"id":"GO:0007190","count":25}]},{"hash":"1729839779955119555","title":"P450-mediated steroid and xenobiotic metabolism","description":"The cluster is dominated by GO terms tied to cytochrome P450 pathways (omega-hydroxylase and epoxygenase), steroid biosynthesis (testosterone, cortisol), bile acid and retinoic acid metabolism, and xenobiotic/alkaloid processing. These collectively point to a set of P450 enzymes driving both endogenous steroid production and xenobiotic/drug metabolism, with retinoid-associated signaling links, hence a cohesive label around P450-driven metabolism and steroidogenesis.","confidence":"High","size":29,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0097267","count":20},{"id":"GO:0019373","count":20},{"id":"GO:0061370","count":20},{"id":"GO:0009822","count":20},{"id":"GO:0034651","count":20}]},{"hash":"2275913702680683849","title":"Neural signaling and transcription regulation","description":"This cluster shows enrichment for signaling pathways (Wnt canonical, ephrin receptor signaling) along with regulation of transcription (DNA-templated transcription), cytoskeletal dynamics (focal adhesion assembly) and axon guidance. The combination points to proteins involved in neural signaling cascades that influence gene expression and cytoskeletal changes.","confidence":"Medium","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090263","count":8},{"id":"GO:0000186","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0050771","count":6},{"id":"GO:0033138","count":6}]},{"hash":"1862949034828842089","title":"Unknown","description":"The terms include RNA splicing, translation initiation/reinitiation, ribosome biogenesis, brain development, GPCR signaling, hypoxia response, and defense to Gram-positive bacteria, which do not point to a single cohesive function or pathway. The cluster seems to be a mix of disparate processes, offering no clear common theme.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":11},{"id":"GO:0000398","count":11},{"id":"GO:0007420","count":11},{"id":"GO:0071456","count":11},{"id":"GO:0001731","count":11}]},{"hash":"2053463536553217050","title":"Diverse biosynthesis and translation processes","description":"This cluster shows enrichment in multiple biosynthetic pathways (lipopolysaccharide, colanic acid, sterol, phenylpropanoid) alongside translation- and transcription-related terms (mitochondrial translation, tRNA wobble modification, DNA-templated transcription) and DNA repair. The functions are varied across metabolism and gene expression rather than a single cohesive pathway, suggesting a broad, core cellular-process theme rather than a specific function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0032543","count":3},{"id":"GO:0016126","count":3},{"id":"GO:0009103","count":3},{"id":"GO:0006281","count":2}]},{"hash":"2299292432900687730","title":"Neural development and immune-regulated cell adhesion","description":"The cluster's top GO terms span neural development processes (axon guidance, synapse assembly, myelination) and cell adhesion, with immune signaling hints (innate immune response, regulation of macrophage activation, NK cell activity). The recurring theme is cell adhesion linking neural maturation with immune regulation, including tissue-specific adhesion in contexts like the AV node. ","confidence":"High","size":29,"edges":6,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043031","count":10},{"id":"GO:0007411","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0042552","count":10}]},{"hash":"292824464493174669","title":"Innate Immune Activation","description":"The top GO terms are dominated by innate immune response, defense against virus, and cellular response to IL-6, indicating a cluster enriched for innate immune signaling and antiviral defense. Additional terms like protein secretion, ubiquitination, and GPCR signaling likely reflect downstream regulatory processes and signaling interplay in immune contexts, but the core theme centers on innate immunity.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0050714","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0045842","count":3},{"id":"GO:0016525","count":3}]},{"hash":"335902918171835157","title":"Peripheral nerve development and axon guidance","description":"The top GO terms are dominated by nervous system development and axon-related processes (peripheral nervous system development, axonal fasciculation, myelination, synapse assembly, and cell adhesion, including Slit-Robo signaling), with some mention of trigeminal nerve organization. This suggests the proteins function together in neural development and nerve fiber organization, especially in the PNS. A minor Innate immune response term appears but does not override the neural-development theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":10},{"id":"GO:0007413","count":10},{"id":"GO:0042552","count":10},{"id":"GO:0051965","count":9},{"id":"GO:0007157","count":9}]},{"hash":"581554341644475866","title":"Immune-Driven Angiogenesis and Coagulation","description":"The cluster is dominated by immune-related terms (complement activation via lectin pathway, adaptive immune response) alongside angiogenesis and endothelial migration, plus coagulation and growth signaling (RTK activation, ERK cascade). This suggests a cohesive theme of immune activation coordinating vascular remodeling and coagulation, with some fungal-origin sensing and broader signaling involvement.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":19},{"id":"GO:0007171","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0043536","count":11},{"id":"GO:0002250","count":11}]},{"hash":"2294535705277582882","title":"LPS-Driven Immune Signaling and Barrier Development","description":"In this cluster, the top GO terms converge on responses to lipopolysaccharide and defense against bacteria, plus processes related to barrier establishment (endothelial/intestinal). Although there are a couple of developmental terms (skeletal system development, neural tube closure), the dominant signal is LPS-triggered immune signaling and barrier-associated functions, with some overlap to developmental signaling in shared proteins.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031663","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0043547","count":3}]},{"hash":"953122956132837813","title":"Innate and adaptive immune signaling","description":"Based on the strongest signals in the Top Terms\u2014innate immune response, complement activation, defense against bacterium, and B/T cell signaling\u2014the cluster appears to group immune recognition and communication across both innate and adaptive arms. While a few terms related to neuronal functions appear, the dominant theme is immune defense and intercellular signaling, justifying a label that emphasizes immune signaling and defense.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":10},{"id":"GO:0006958","count":8},{"id":"GO:0060079","count":8},{"id":"GO:0050910","count":7},{"id":"GO:0050853","count":7}]},{"hash":"544236122582591921","title":"Ubiquitination-mediated innate immune signaling","description":"The terms show a clear focus on innate immune response and antiviral defense, with explicit ubiquitination processes (K63- and K6-linked) and regulation of NF-kappaB signaling, plus vitamin D\u2013related immune modulation. This suggests a cohesive cluster centered on ubiquitin-dependent signaling in innate immunity, with supporting roles for chromatin modification and microtubule localization.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033280","count":25},{"id":"GO:0051092","count":25},{"id":"GO:0051865","count":25},{"id":"GO:0045087","count":25},{"id":"GO:0070534","count":25}]},{"hash":"2018021916847308373","title":"Neural signaling and sensory perception","description":"The top GO terms cluster around neural signaling and sensory processing: GPCR signaling, Rho-mediated signaling, dopaminergic synaptic transmission, and sensory modalities like pain and vision. While there are additional terms related to metabolism and cardiovascular regulation, the strongest and most coherent signal ties to neural communication and sensory function, making this an apt, specific label.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0035025","count":17},{"id":"GO:0019233","count":15}]},{"hash":"2303004549977469261","title":"Neuroimmune Signaling and Angiogenesis","description":"The dominant GO terms point to inflammatory and apoptosis signaling (NF-kappaB regulation, TNF production, DISC assembly) alongside neural development (synapse assembly, axonal fasciculation) and vascular growth (angiogenesis). Even with no reported edges, these annotations suggest a cohesive theme of cross-talk between immune signaling, neural connectivity, and angiogenic processes, rather than a single tightly connected pathway.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051092","count":7},{"id":"GO:0051965","count":6},{"id":"GO:0071550","count":6},{"id":"GO:0002318","count":6},{"id":"GO:0043552","count":6}]},{"hash":"434043744122961278","title":"Developmental Signaling Across Tissues","description":"The top GO terms point to signaling responses (cAMP/cGMP, Rho) and tissue-specific development processes (myelination, axon guidance, sarcomere organization, atrial septum development). This suggests a broad theme of signaling guiding tissue differentiation and organization, with chromatin remodeling and DNA damage response terms representing regulatory context rather than a single pathway. The label captures the overall pattern without overcommitting to a single function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0071321","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0071320","count":2}]},{"hash":"834115772086853240","title":"Innate Immune Regulation and Cell Adhesion","description":"The top terms cluster around innate immunity (innate immune response, classical complement activation) and immune regulation (negative regulation of macrophage activation, NK and T cell activity), along with cell-cell adhesion (homophilic/heterophilic adhesion). This suggests a module of immune signaling coupled to cell adhesion processes, rather than a single metabolic or structural function.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0045087","count":14},{"id":"GO:0006958","count":14},{"id":"GO:0043031","count":13},{"id":"GO:0002859","count":13}]},{"hash":"1131678429531457218","title":"RNA Splicing and Translation Regulation","description":"The terms cluster around RNA processing and translation control, including alternative splicing regulation via the spliceosome, splice site recognition, mRNA export, mRNA modification, and regulation of translational initiation and preinitiation complex formation, as well as translation reinitiation. This suggests the proteins in this cluster coordinate RNA maturation with control of translation initiation.","confidence":"High","size":28,"edges":45,"triangles":17,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":5},{"id":"GO:0000381","count":4},{"id":"GO:0002188","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0016556","count":3}]},{"hash":"2224343588249576290","title":"Nuclear import and pore complex assembly","description":"Most terms indicate nuclear transport: NLS-bearing protein import into nucleus, ribosomal protein import, and nuclear pore complex assembly; several entries reference translocation into nucleus and regulation of transport-related processes (GTPase activity, desumoylation). This makes the cluster cohesive around nuclear import and pore assembly, with a few related cell-cycle/apoptosis signals that may reflect broader cellular context.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0043547","count":11},{"id":"GO:0006607","count":10},{"id":"GO:0000060","count":9},{"id":"GO:0051292","count":9},{"id":"GO:0006610","count":9}]},{"hash":"1285069429181724551","title":"Developmental signaling and morphogenesis regulation","description":"The top GO terms cluster around modulation of signaling pathways (notably negative regulation of Wnt signaling) and processes tied to development, such as cell migration, apoptosis/proliferation control, and morphogenesis. There are also hints of cytoskeletal dynamics (GTPase activity) and tissue patterning (larval cuticle formation), suggesting a set of proteins regulating developmental signaling and morphogenesis rather than a single metabolic function.","confidence":"Medium","size":28,"edges":325,"triangles":2178,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090090","count":11},{"id":"GO:0016477","count":11},{"id":"GO:0043065","count":11},{"id":"GO:0008285","count":11},{"id":"GO:0015991","count":11}]},{"hash":"1179362297527735071","title":"DNA Damage Response and Stress-Induced Apoptosis","description":"Most terms point to DNA damage response: DNA recombination, base-excision repair, and DNA catabolic process, together with apoptosis and cellular responses to oxidative/xenobiotic stress. This pattern fits a cluster of proteins that detect and repair DNA damage and coordinate apoptosis when damage is severe.","confidence":"High","size":28,"edges":32,"triangles":7,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":16},{"id":"GO:0006915","count":12},{"id":"GO:0070301","count":12},{"id":"GO:0090502","count":12},{"id":"GO:0006284","count":12}]},{"hash":"1543622823976671202","title":"Cell fate signaling and differentiation","description":"This cluster is enriched for GO terms related to signaling pathways that control cell growth, lineage specification, and differentiation (Wnt and Hippo signaling; keratinocyte differentiation; NK T cell differentiation; hemopoiesis; growth hormone receptor signaling) and includes apoptotic regulation, suggesting a core theme around how signaling governs cell fate decisions and development, with some broad ties to immune and skin lineages.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090263","count":15},{"id":"GO:0035329","count":13},{"id":"GO:0060044","count":13},{"id":"GO:0006915","count":13},{"id":"GO:0030216","count":13}]},{"hash":"1435158396914790206","title":"Viral DNA Integration and Host Gene Expression","description":"The top GO terms reveal a blend of DNA integration and proviral latency processes with core gene expression activities (transcription elongation, translation, ribosome biogenesis) and cell-cycle/division functions, suggesting a theme around viral genome integration influencing host transcription/translation machinery and cell proliferation.","confidence":"High","size":28,"edges":67,"triangles":66,"max_degree":27,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006354","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0007049","count":3}]},{"hash":"2146888891038353105","title":"Embryonic Organ Morphogenesis and Development","description":"The Top Terms point to broad embryonic development and morphogenesis across multiple organs (eye, lung, heart, ovary, pituitary, etc.), indicating a cohesive theme of organ formation during embryogenesis. The presence of RNA polymerase II transcription underscores general transcription accompanying these programs, rather than a single tissue-specific pathway, supporting a developmental-morphogenesis focus.","confidence":"High","size":28,"edges":8,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001701","count":12},{"id":"GO:0048048","count":10},{"id":"GO:0006366","count":8},{"id":"GO:0071455","count":7},{"id":"GO:0042551","count":7}]},{"hash":"1455251485736450044","title":"ECM remodeling and angiogenesis with inflammatory signaling","description":"The cluster features collagen fibril organization, sprouting angiogenesis, endothelial proliferation, and integrin signaling, alongside inflammatory and innate immune responses and complement activation. This combination points to extracellular matrix remodeling coupled with vascular development and inflammatory processes, with some broad developmental terms (e.g., spinal cord and neuron differentiation) that may reflect shared signaling in development.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":4},{"id":"GO:0032332","count":3},{"id":"GO:0001935","count":3},{"id":"GO:2001046","count":3},{"id":"GO:0021510","count":3}]},{"hash":"2150030264043290357","title":"Neural development and axon guidance","description":"Terms indicate neural development, neuron migration, Schwann cell development, and axon guidance, with supporting roles in cell\u2013cell adhesion and extracellular matrix remodeling (e.g., receptor clustering, PCP signaling). This suggests a cohesive function in nervous system development and axon pathfinding.","confidence":"High","size":28,"edges":361,"triangles":2884,"max_degree":27,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043113","count":13},{"id":"GO:0090179","count":13},{"id":"GO:0097477","count":10},{"id":"GO:0070527","count":10},{"id":"GO:0022617","count":10}]},{"hash":"998879862232873855","title":"Biosynthesis and RNA Modification Cluster","description":"The top GO terms point to biosynthetic processes (antibiotic, biotin, chlorophyll, nodulation) and to various RNA-related modification activities (mRNA capping, tRNA wobble modification, RNA methylation, arginine methylation). This suggests a shared theme of synthesis and RNA-based modification enzymes, despite some peripheral terms like nodulation. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":13},{"id":"GO:0009877","count":13},{"id":"GO:1901052","count":13},{"id":"GO:0006370","count":13},{"id":"GO:0002098","count":13}]},{"hash":"2295499096436624106","title":"Embryonic development and organ morphogenesis","description":"This cluster\u2019s top GO terms span development and morphogenesis across multiple tissues and organs (nipple morphogenesis, kidney glomerulus development, lung connective tissue development, cartilage morphogenesis, left-right pattern formation, pancreatic cell and endocrine system development, trophoblast differentiation, and EMT in heart development). The shared theme is broad developmental processes shaping organ formation, with one outlier term (inflammatory response) that does not redefine the overall theme. Therefore the label reflects the dominant function of the proteins. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060658","count":2},{"id":"GO:0072224","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0060707","count":2}]},{"hash":"1396878888546719099","title":"Photoreceptor outer segment and cilium proteins","description":"This cluster centers on retinal/ciliary biology: multiple terms describe photoreceptor outer segment organization and protein localization to photoreceptor outer segments, as well as regulation of non-motile cilium assembly and microtubule anchoring at the centrosome, all signaling a cohort of ciliary/photoreceptor transport and assembly proteins. A few terms about general development (fat pad, striatum) are less connected and may reflect broad roles or noise, but the core signal is retinal ciliary function.","confidence":"Medium","size":28,"edges":6,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060613","count":4},{"id":"GO:0070301","count":4},{"id":"GO:0000278","count":4},{"id":"GO:1903546","count":3},{"id":"GO:1902855","count":3}]},{"hash":"2042273410132797007","title":"Vascular inflammation and coagulation","description":"Based on the top GO terms, the proteins are enriched for complement activation (lectin pathway), coagulation and fibrin clot formation, endothelial responses to cytokines (IL-6, IL-1) and vasoconstriction, plus cell-surface localization and cell-matrix adhesion. This points to a cohesive function in vascular inflammation and coagulation processes, with surface proteins mediating adhesion and signaling in endothelial cells, and additional stress response cues (e.g., UV-B). ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":16},{"id":"GO:0072378","count":15},{"id":"GO:1902042","count":15},{"id":"GO:0045907","count":15},{"id":"GO:0007160","count":15}]},{"hash":"1104253864789941452","title":"Steroid hormone biosynthesis and retinoid metabolism","description":"The cluster shows strong representation of steroid-related biosynthetic processes (testosterone, androgen, estrogen, glucocorticoid biosynthesis) and retinoid metabolism (retinol/retinal), with accompanying pigment biosynthesis (melanin). This suggests a cohesive functional theme centered on steroidogenesis and retinoid/pigment pathways, possibly with tissue contexts like lung or retina.","confidence":"Medium","size":28,"edges":106,"triangles":92,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":23},{"id":"GO:0030324","count":22},{"id":"GO:0042574","count":21},{"id":"GO:0061370","count":21},{"id":"GO:0017000","count":21}]},{"hash":"556274400505595166","title":"Steroid and Prostaglandin Lipid Metabolism via P450s","description":"The cluster centers on prostaglandin biosynthesis, steroid hormone production (testosterone, cortisol), triglyceride metabolism, and P450-driven omega-hydroxylase/epoxygenase pathways, with xenobiotic catabolic terms. The retina vasculature development term can reflect prostaglandin signaling in ocular vessels, supporting a cohesive theme of endogenous lipid signaling and steroid synthesis mediated by cytochrome P450 enzymes.","confidence":"High","size":28,"edges":166,"triangles":414,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":19},{"id":"GO:0046232","count":16},{"id":"GO:0060065","count":16},{"id":"GO:0006641","count":16},{"id":"GO:0097267","count":15}]},{"hash":"868678903110838075","title":"Innate Immune Activation and Pyroptotic Cell Death","description":"The dominant GO terms point to innate immunity and inflammatory cell death (innate immune response, pyroptotic inflammatory response, apoptotic process) with supporting roles for ubiquitination and macrophage regulation, suggesting a cohesive module in immune signaling and inflammatory cell death, despite one spindle-related term that may reflect multifunctional proteins.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":15},{"id":"GO:0045087","count":15},{"id":"GO:0006915","count":14},{"id":"GO:0070269","count":14},{"id":"GO:0016567","count":14}]},{"hash":"212578801359561771","title":"Immune Activation and Inflammatory Signaling","description":"Most top GO terms cluster around immune responses and cytokine production (cellular response to LPS, activation and proliferation of T cells, and positive regulation of IL-3 and GM-CSF). While there are outliers related to development and replication, the dominant theme among the terms is immune signaling and inflammatory processes.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":28},{"id":"GO:0006260","count":28},{"id":"GO:1901925","count":27},{"id":"GO:0045401","count":27},{"id":"GO:0045425","count":27}]},{"hash":"2077844735433290373","title":"Neurovascular development and ECM remodeling","description":"This cluster centers on developmental processes spanning neural (axonogenesis, visual perception, synaptic activity) and vascular/heart-related pathways (heart development, angiogenesis regulation, blood coagulation), plus extracellular matrix remodeling (collagen fibril organization) and inflammatory responses. The common thread is coordinated tissue development and remodeling across neural and vascular contexts, rather than a single narrow function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007409","count":5},{"id":"GO:0007601","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0060079","count":4}]},{"hash":"1983950750253590034","title":"Neural development and axon guidance","description":"The dominant GO terms point to neuronal development and axon pathfinding, including CNS projection neuron axonogenesis, motor neuron axon fasciculation, and regulation of neuronal growth/death. A few immune-related terms appear but are less cohesive with the main neuronal theme, suggesting the core function is neural development with axon guidance as the key signal. Confidence: Medium","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0045401","count":27},{"id":"GO:0045425","count":27},{"id":"GO:2000811","count":27},{"id":"GO:0050798","count":27},{"id":"GO:0048544","count":27}]},{"hash":"470285730128038602","title":"Angiogenesis and ECM remodeling","description":"The GO terms are dominated by angiogenesis-related processes (angiogenesis, its positive and negative regulation, endothelial cell migration) and extracellular matrix dynamics (cell-matrix adhesion, collagen fibril organization), suggesting a module of proteins guiding vascular development and matrix remodeling. Additional terms on ERK signaling and immune involvement (adaptive immune response, lectin pathway complement activation) indicate a broader context of tissue remodeling that can include immune modulation. Overall, this cluster centers on vascular formation and ECM interactions with supportive roles for signaling and immunity.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007160","count":23},{"id":"GO:0045766","count":22},{"id":"GO:0030199","count":22},{"id":"GO:0001867","count":21},{"id":"GO:0043536","count":21}]},{"hash":"2249504429839191252","title":"Coagulation and vascular remodeling","description":"These terms cluster around coagulation/fibrinolysis (blood clot formation, plasminogen activation), complement activation, collagen fibril organization, and angiogenesis, pointing to a wound-healing/vascular-remodeling program. Inflammatory signaling (IL-1) and axon regeneration at NMJ add tissue-repair context, supporting a cohesive theme of vascular and extracellular matrix remodeling during healing.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":14},{"id":"GO:0007171","count":13},{"id":"GO:0031639","count":13},{"id":"GO:0045766","count":13},{"id":"GO:0042730","count":13}]},{"hash":"1297296597965347665","title":"Cardiac morphogenesis and neural differentiation","description":"Top GO terms are dominated by cardiac development processes (endocardial cushion, aortic valve morphogenesis, ventricular septum development) with an additional signal for forebrain neuronal differentiation. This points to a developmental program spanning heart morphogenesis and neural differentiation, rather than a single specific pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030210","count":2},{"id":"GO:0036071","count":2},{"id":"GO:0060017","count":2},{"id":"GO:0051891","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1570480645705303054","title":"Multicellular development and differentiation","description":"This cluster's top GO terms center on developmental processes (oligodendrocyte differentiation; multicellular organism development; multicellular organismal process) and related growth signals, with additional cell-cycle and mechanosensitive response terms, suggesting a broad developmental program rather than a single specific pathway. Some other terms (ion export, lipid catabolism) may reflect general cellular remodeling during development.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048709","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0097284","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0051301","count":3}]},{"hash":"781721695161734235","title":"Ubiquitin-Dependent Proteolysis and NF-kappaB Signaling","description":"The top GO terms are dominated by ubiquitination-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, various ubiquitin linkages) and signaling pathways including TNF and NF-kappaB. This points to a cohesive function in ubiquitin-mediated protein turnover and signaling regulation, with additional related processes like V(D)J recombination and chromatin regulation reflected by histone ubiquitination terms. Overall, the cluster seems best characterized by ubiquitin-driven regulation of cellular signaling and proteolysis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":22},{"id":"GO:0051865","count":19},{"id":"GO:0009048","count":18},{"id":"GO:0033209","count":18},{"id":"GO:0033151","count":18}]},{"hash":"1298790752025051988","title":"Neural development: axon guidance and synapse assembly","description":"The top GO terms cluster around neural development and connectivity: myelination, axon guidance and fasciculation, synapse assembly and its regulation, embryonic morphogenesis, Hedgehog signaling (Smoothened), and cell adhesion. These collectively suggest proteins involved in neuronal differentiation and the formation of neural circuits. The lone term about symbiont entry into a host cell seems peripheral to this theme and may reflect shared membrane-trafficking functions rather than a core neural role. Overall, the cluster is best described as neural development and synaptic organization.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042552","count":6},{"id":"GO:0051965","count":5},{"id":"GO:0007413","count":5},{"id":"GO:0048598","count":5},{"id":"GO:0007224","count":5}]},{"hash":"2104007133233742157","title":"Unknown","description":"The top GO terms span neural development (synapse assembly, axon guidance), muscle fusion, immune signaling, apoptosis, and host\u2013pathogen interactions with no single cohesive function or molecular theme tying all proteins together. Given the diverse processes, there isn\u2019t a clear representative function for this cluster.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0035418","count":3},{"id":"GO:0051963","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0007520","count":3}]},{"hash":"977885496777788468","title":"ECM remodeling and angiogenesis regulation","description":"This cluster is dominated by extracellular matrix components and vascular development signals: collagen fibril organization, cell-matrix adhesion, and heparin proteoglycan biosynthesis point to ECM remodeling, while negative/positive regulation of angiogenesis, endothelial cell migration, and blood coagulation indicate vascular signaling. Some terms related to sensory processes (sensory perception of sound, otolith tethering) may reflect ECM roles in sensory tissues rather than a separate function. Overall, the key theme is ECM-driven regulation of angiogenesis and vascular dynamics.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016525","count":11},{"id":"GO:0030199","count":10},{"id":"GO:0007160","count":10},{"id":"GO:0007605","count":8},{"id":"GO:0035889","count":8}]},{"hash":"1260183258002433108","title":"Ribosome biogenesis and nuclear export","description":"The majority of top GO terms relate to ribosome assembly and export of ribosomal subunits from the nucleus, including maturation of SSU-rRNA and large subunit biogenesis, plus mRNA export and translation, indicating a cluster centered on ribosome production and early gene expression steps. This label captures the central theme of the cluster without overgeneralizing.","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":7},{"id":"GO:0000055","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0006406","count":4},{"id":"GO:0000056","count":4}]},{"hash":"916748201552334357","title":"Developmental Processes and Transcription","description":"The proteins in this cluster are enriched for developmental terms (skeletal system development, angiogenesis, multicellular organism development, lens fiber cell differentiation, neural tube closure) and transcriptional regulation (DNA-templated transcription, mitotic cell cycle, CDK activity regulation, SREBP signaling), suggesting a cohesive role in development and gene expression control. A defense-related term appears less central. ","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0001843","count":3}]},{"hash":"473548926677343286","title":"Ribosome Biogenesis and Translation Machinery","description":"This cluster is dominated by translation-related terms: translation, translational initiation and termination, ribosome biogenesis and large subunit assembly, and selenocysteine incorporation, with supporting signals of mRNA decay linked to translation and a beta signal of antibiotic response. Together, these terms point to a cohesive group of proteins involved in ribosome function, assembly, and protein synthesis, with some regulation of translational fidelity.","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":22},{"id":"GO:0046677","count":6},{"id":"GO:0006415","count":6},{"id":"GO:0042254","count":5},{"id":"GO:0000027","count":5}]},{"hash":"2025292949660874380","title":"Cell Division and Ribosome Biogenesis","description":"The cluster is dominated by cell-cycle and division terms (cell division, mitotic cell cycle, division septum assembly, chromosome alignment) and ribosome-related processes (ribosome biogenesis, tRNA modification), suggesting a core theme of growth-linked division with protein synthesis. Some terms also hint at ciliogenesis and neuronal polarity, but the primary signal centers on cell-cycle machinery and RNA-based growth. ","confidence":"Medium","size":27,"edges":69,"triangles":68,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0000278","count":6},{"id":"GO:0006400","count":6},{"id":"GO:1902857","count":5},{"id":"GO:0007224","count":5}]},{"hash":"1587200464007336758","title":"Organogenesis and tissue remodeling","description":"The top GO terms center on developmental processes across organs (lung development, ossification, male gonad development) and growth regulation, with additional signals related to immune regulation (membrane attack complex activation) and nitric oxide signaling. This mix suggests a theme of coordinated organ formation and tissue remodeling, with ancillary immune/modulatory involvement.","confidence":"Medium","size":27,"edges":28,"triangles":7,"max_degree":9,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0001970","count":5},{"id":"GO:0010751","count":5},{"id":"GO:0030324","count":5},{"id":"GO:0001558","count":5},{"id":"GO:0019800","count":4}]},{"hash":"765457680169438819","title":"Ribosome Biogenesis and Translation Initiation","description":"The cluster is dominated by GO terms related to ribosome biogenesis, formation of the translation preinitiation complex, and translation reinitiation, with TORC1 signaling and mRNA transport aligning with translation control and growth regulation. While a few terms (e.g., meiotic spindle elongation, extrinsic apoptotic signaling, GTPase regulation) are less central, the core theme points to protein synthesis machinery assembly and its regulation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0070262","count":3},{"id":"GO:0051232","count":3},{"id":"GO:0038202","count":3},{"id":"GO:0051028","count":3}]},{"hash":"20015386928428837","title":"Unknown","description":"The GO terms span ubiquitination, multiple development processes (heart, nipple morphogenesis, metanephric glomerulus), immune responses (innate, B cell signaling), inflammation, and even visual perception. These terms reflect diverse, context-specific roles rather than a single cohesive function, so no clear, representative label can be assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0045736","count":2}]},{"hash":"1321346443287009062","title":"Epithelial Barrier Adhesion and Innate Immunity","description":"The strongest signals are cell\u2013cell adhesion (heterophilic/homophilic) and innate immune functions (innate immune response, complement activation), with GI epithelium maintenance pointing to barrier integrity. Additional terms like symbiont entry into host cell and T cell\u2013mediated cytotoxicity suggest host\u2013microbe interactions and immune regulation, while some terms (synapse assembly, spermatid development) appear less connected to the core theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0006958","count":14},{"id":"GO:0030277","count":11},{"id":"GO:0007156","count":10},{"id":"GO:0043031","count":9}]},{"hash":"1916812089136745871","title":"Unknown","description":"The top GO terms are highly diverse, spanning antibiotic and alkaloid biosynthesis, poly-hydroxybutyrate biosynthesis, various metabolic processes (steroid/hormone, retinal, phylloquinone), and even development-related terms (lung, retinal) or sporulation, with no clear shared pathway. There are no observed edges or interactions linking the proteins, so there isn\u2019t a cohesive functional theme to name beyond general, disparate metabolism. ","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0042619","count":3},{"id":"GO:0042208","count":2},{"id":"GO:0008207","count":2}]},{"hash":"124084661864742588","title":"Neural development and axon guidance","description":"The cluster is dominated by GO terms related to nervous system development, neural tube closure, axon pathfinding and synapse formation (e.g., nervous system development, neural tube closure, axonal fasciculation, sympathetic neuron projection guidance, semaphorin-plexin signaling in axon guidance). A single innate immune term appears but the prevailing pattern points to neurodevelopment and axon guidance processes, with some associated heart development term likely reflecting broader developmental contexts. ","confidence":"High","size":27,"edges":65,"triangles":0,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0051965","count":4}]},{"hash":"763567464082089196","title":"Lipid and Carbohydrate Metabolism","description":"The top GO terms cluster around lipid-related biosynthesis and turnover (fatty acid beta-oxidation via acyl-CoA oxidase; prostaglandin metabolism; ascaroside biosynthesis) and glycan biosynthesis (lipopolysaccharide and O antigen biosynthesis). Carbohydrate metabolism terms (glycogen biosynthesis; galactose catabolic process) and amino acid metabolism (L-glutamine) are also present, suggesting a broad metabolic theme rather than a single pathway. This supports labeling the cluster as lipid and carbohydrate metabolism.","confidence":"Medium","size":27,"edges":3,"triangles":0,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0033540","count":5},{"id":"GO:0006693","count":5},{"id":"GO:1904070","count":5},{"id":"GO:0009103","count":5},{"id":"GO:0009243","count":5}]},{"hash":"1337705825559230756","title":"Broad Substrate Transmembrane Transporters","description":"The cluster is dominated by GO terms for transmembrane transport of diverse substrates (vitamins, xenobiotics, neurotransmitters, sugars, ions), indicating a cohesive group of membrane transport proteins facilitating uptake and movement of these molecules across membranes.","confidence":"High","size":27,"edges":56,"triangles":6,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":27},{"id":"GO:0006855","count":27},{"id":"GO:0042891","count":23},{"id":"GO:0042908","count":23},{"id":"GO:0071805","count":23}]},{"hash":"171094449551906495","title":"Adrenergic Cardiovascular Regulation","description":"This cluster is dominated by GO terms related to blood pressure regulation, vasoconstriction, heart rate modulation by epinephrine/norepinephrine, and adenylate cyclase GPCR signaling, which point to sympathetic/adrenergic control of cardiovascular function. The presence of electron transport chain and heat generation terms may reflect higher energy demand in active cardiac tissues, supporting a metabolically active state; a few unrelated terms appear as noise but do not override the core theme. Therefore, the label captures the main functional theme.","confidence":"High","size":27,"edges":70,"triangles":25,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":26},{"id":"GO:0007190","count":26},{"id":"GO:0010579","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0060658","count":24}]},{"hash":"309408494224278078","title":"Complement and Coagulation with Angiogenic Signaling","description":"The GO terms cluster around immune/complement activation (lectin pathway) and coagulation/fibrinolysis (plasminogen activation, fibrinolysis), plus extracellular matrix interactions and growth signaling (cell-matrix adhesion, ERK cascade, RTK activation) that promote angiogenesis. Adaptive immunity and neural signaling appear as broader tissue-level context, but the core pattern ties immune/coagulation remodeling to vascular growth. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0007160","count":9},{"id":"GO:0031639","count":8},{"id":"GO:0042730","count":8},{"id":"GO:0070374","count":8}]},{"hash":"2193446266049697647","title":"Neurodrug Response and Vascular Inflammation","description":"It ties together neural responses to drugs (amphetamine, morphine), learning and locomotion, and vascular/inflammatory processes (vasoconstriction, inflammatory response, blood coagulation), plus xenobiotic stimulus, suggesting proteins involved in neurobehavioral drug response and associated vascular inflammation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001975","count":5},{"id":"GO:0008542","count":5},{"id":"GO:0007626","count":5},{"id":"GO:0045907","count":5},{"id":"GO:0043278","count":4}]},{"hash":"1908194804601642203","title":"Plant glycoprotein and mucilage biosynthesis","description":"These terms cluster around plant-specific glycan and cell-surface components, including arabinogalactan protein metabolism, seed coat mucilage biosynthesis, root hair development, and glycan epitope synthesis (Lewis a, poly-N-acetyllactosamine). Together they suggest a theme of plant cell wall/glycoprotein biosynthesis and mucilage production, with a few unrelated DNA repair terms likely representing background noise.","confidence":"Medium","size":27,"edges":57,"triangles":10,"max_degree":10,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0080147","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0006281","count":3},{"id":"GO:0030311","count":3},{"id":"GO:0001744","count":3}]},{"hash":"2113456291250240784","title":"Translation and tRNA charging","description":"Based on the GO terms, the cluster centers on protein synthesis and tRNA charging, with strong signals for translation (GO:0006412), regulation of translational fidelity (GO:0006450), and valyl-tRNA aminoacylation (GO:0006438). These collectively point to components of the translation machinery and tRNA charging enzymes. A few other terms appear (stress or metabolic processes), but they are peripheral compared to the core translation-related terms.","confidence":"High","size":27,"edges":216,"triangles":710,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006450","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0006438","count":2},{"id":"GO:0006915","count":1}]},{"hash":"1201474240633294497","title":"Lectin-complement innate immune signaling","description":"The top GO terms indicate strong representation of lectin pathway\u2013driven complement activation, lectin receptor signaling, Fc-gamma receptor signaling, and leukocyte adhesion steps, all core to innate immune responses and inflammation; a few development-related terms likely reflect context rather than core function. This points to a cohesive theme of innate immune signaling mediated by lectins and Fc receptors.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001867","count":15},{"id":"GO:0072218","count":13},{"id":"GO:2000502","count":13},{"id":"GO:0050901","count":13},{"id":"GO:0038094","count":13}]},{"hash":"1583027748086508766","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043029","count":7},{"id":"GO:0048535","count":7},{"id":"GO:0061158","count":6},{"id":"GO:0001782","count":6},{"id":"GO:0002635","count":6}]},{"hash":"313020903831922798","title":"Pyroptosis and apoptosis with ubiquitin signaling","description":"Top GO terms indicate a core theme of regulated cell death (apoptosis and pyroptosis) coupled with ubiquitin-mediated signaling and innate immune responses, suggesting proteins in this cluster coordinate inflammatory cell death and immune signaling. A peripheral term for mitotic spindle assembly may reflect multifunctional proteins but does not outweigh the death/immune signal.","confidence":"High","size":27,"edges":7,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":26},{"id":"GO:0070269","count":26},{"id":"GO:0016567","count":26},{"id":"GO:1990001","count":26},{"id":"GO:0045087","count":26}]},{"hash":"1054122979363119640","title":"Muscle differentiation and cell-adhesion signaling","description":"Based on GO terms like positive regulation of myoblast differentiation, skeletal system development, integrin-mediated signaling, and homophilic/heterophilic cell-cell adhesion, this cluster reflects a developmentally coordinated program of muscle formation and adhesion signaling. While DNA-templated transcription and synapse assembly appear, the core theme centers on differentiation and adhesion pathways relevant to muscle lineage.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0051965","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0007157","count":4},{"id":"GO:0045746","count":4}]},{"hash":"2018966476784691463","title":"T cell signaling and thymic development","description":"The top GO terms cluster around immune-related processes, notably ephrin receptor signaling, activated T cell proliferation, thymus development, and regulation of T cell receptor signaling, with supporting signals from Rho pathway regulation, nitric oxide response, and ubiquitination. This pattern suggests the proteins function together in T cell activation and thymic development pathways, with Eph/ephrin signaling as a related mechanism.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":5},{"id":"GO:0050798","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0048538","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1288513054034096599","title":"Neural development and ECM remodeling","description":"This cluster features multiple neural development terms: positive regulation of synapse assembly; axon extension involved in axon guidance; corticospinal neuron axon guidance through spinal cord; retinal ganglion cell axon guidance; and synapse assembly, all pointing to neuronal growth and connectivity. The extracellular matrix theme is highlighted by collagen fibril organization and the chondroitin sulfate glycosaminoglycan cross-linking term, suggesting ECM components shaping guidance cues. A few terms relate to signaling and stress/immune contexts (negative regulation of chemokine signaling, induction of cortisol response) that may reflect broader regulatory environments but don't override the predominant neural-ECM signal. Overall, the cluster likely represents proteins involved in neural development with ECM interactions guiding axon pathfinding and synapse formation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019800","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0021972","count":3},{"id":"GO:0050929","count":3},{"id":"GO:0070100","count":3}]},{"hash":"164754450330676615","title":"Ubiquitin-Dependent NF-kappaB/TNF Immune Signaling","description":"The cluster centers on ubiquitin-mediated protein turnover and regulation, with strong representation of ubiquitination (including autoubiquitination and histone ubiquitination) and signaling pathways such as TNF, NF-kappaB, I-kappaB phosphorylation, and JNK; V(D)J recombination hints at an immune context, suggesting a cohesive role in ubiquitin-dependent control of immune signaling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":22},{"id":"GO:0051865","count":18},{"id":"GO:0009048","count":17},{"id":"GO:0033209","count":17},{"id":"GO:0007250","count":17}]},{"hash":"178913554433601458","title":"Angiogenesis and ECM remodeling with GPCR signaling","description":"These terms point to a vascular development and extracellular matrix remodeling program, with mechanotransduction and GPCR-driven signaling as central mediators. Angiogenesis and its negative VEGF regulation, together with collagen fibril organization and mechanical stimulus response, define a vascular/ECM signaling module, while related extrinsic apoptotic pathway regulation suggests coordination with cell fate decisions in this context.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0030199","count":3},{"id":"GO:2001241","count":3},{"id":"GO:1902042","count":3}]},{"hash":"921252357625451801","title":"Ribosome biogenesis and translation","description":"The cluster shows multiple GO terms centered on ribosome biogenesis, ribosome assembly, LSU maturation, and translation, indicating proteins involved in producing and assembling ribosomes, particularly the large subunit, as well as general translation activity. A few transcription-related terms are present but appear ancillary to the dominant ribosome-focused functions.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0061188","count":2},{"id":"GO:0006353","count":2}]},{"hash":"1966278890179035073","title":"Transcription, Ribosome Biogenesis, and Development","description":"The top GO terms center on DNA-templated transcription and RNA processing (including RNA guanine-N7 methylation), plus ribosome biogenesis and multiple developmental processes (forebrain, skeletal system, multicellular organism development). There is also involvement of proteasomal ubiquitin-dependent protein catabolic process and a defense response to Gram-positive bacteria, suggesting protein turnover and immune signaling components. Overall, the cluster appears to reflect a broad regulatory theme around gene expression and growth/development, with housekeeping and cellular maintenance processes contributing as well; it is not tied to a single precise pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0036265","count":4},{"id":"GO:0006349","count":3},{"id":"GO:0031146","count":3}]},{"hash":"2046128612218257187","title":"Ribosome biogenesis and translation initiation","description":"The dominant GO terms point to ribosome assembly and rRNA maturation (5.8S, LSU/SSU), formation of the translation preinitiation complex, and translation reinitiation, with ribosomal large subunit biogenesis also prominent. While mRNA splicing and some developmental/hypoxia terms appear, they seem secondary to the core ribosome-related processes, justifying a label centered on ribosome biogenesis and translation initiation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":12},{"id":"GO:0000462","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0042273","count":7}]},{"hash":"370056426952965950","title":"Chromatin remodeling and transcriptional regulation","description":"The strongest signals are chromatin- and transcription-focused: transcription initiation-coupled chromatin remodeling, heterochromatin formation (rDNA, silent mating-type cassette), DNA replication\u2013dependent chromatin assembly, and histone methylation regulation, all pointing to epigenetic control of transcription. A defense response term appears but is less central, making the chromatin/transcription theme the most representative. ","confidence":"High","size":26,"edges":110,"triangles":206,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0050830","count":7},{"id":"GO:0045815","count":7},{"id":"GO:0051290","count":7},{"id":"GO:0000183","count":7}]},{"hash":"1402830541131751351","title":"Cerebellar cortex development and Bergmann glia differentiation","description":"Dominated by cerebellum-specific developmental terms (cerebellar cortex formation, Bergmann glial differentiation) with support from neural growth and axon regeneration regulation. Some general signaling terms (insulin, T cell receptor signaling) are present but do not override the cerebellar development signal. Overall, the cluster appears to reflect cerebellar neurodevelopment and glial differentiation.","confidence":"High","size":26,"edges":293,"triangles":1956,"max_degree":25,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0048679","count":26},{"id":"GO:0008285","count":26},{"id":"GO:0021697","count":26},{"id":"GO:0008286","count":26},{"id":"GO:0045736","count":26}]},{"hash":"1649591420009151160","title":"Angiogenesis and coagulation regulation","description":"The top GO terms cluster around vascular processes: regulation of endothelial cell survival, angiogenesis (positive and negative), fibrinolysis/plasminogen activation, collagen fibril organization, and innate immune components such as complement activation and IL-1 signaling. This points to a cohesive theme of vascular remodeling coupled with coagulation and inflammatory regulation.","confidence":"High","size":26,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000352","count":10},{"id":"GO:0001867","count":9},{"id":"GO:0090331","count":9},{"id":"GO:0031639","count":9},{"id":"GO:0045766","count":9}]},{"hash":"812511482987560775","title":"Neurovascular signaling and plasticity","description":"This cluster centers on neural development and synaptic plasticity (learning, synapse structural plasticity) and ephrin receptor signaling, with a component related to endothelial tube lumen extension, suggesting neurovascular signaling. The presence of translation- and ribosome-related terms implies active protein synthesis accompanying these signaling processes. Together, the proteins likely participate in signaling coordinating neural development and vascular remodeling, with concurrent gene expression machinery.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0007612","count":2},{"id":"GO:0097498","count":2},{"id":"GO:0051835","count":2},{"id":"GO:0048013","count":2}]},{"hash":"1315369745925268321","title":"Programmed cell death and innate immune signaling","description":"This cluster is dominated by GO terms for apoptotic and pyroptotic processes, along with ubiquitination and innate immune response, suggesting a cohesive role in programmed cell death regulation and immune signaling. A mitotic spindle term appears less central, likely incidental. ","confidence":"High","size":26,"edges":72,"triangles":74,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":18},{"id":"GO:0070269","count":18},{"id":"GO:0016567","count":18},{"id":"GO:1990001","count":18},{"id":"GO:0045087","count":18}]},{"hash":"1349526860053952003","title":"Neural development and axon guidance","description":"The terms show a clear emphasis on nervous system development and axon pathfinding: central nervous system projection neuron axonogenesis, fasciculation of motor neuron axon, and regulation of developmental growth. While there are a few immune or vascular terms present (e.g., cytokine production, endothelial chemotaxis), the dominant signal ties to neural growth and neuron connectivity rather than immune or other processes.","confidence":"Medium","size":26,"edges":48,"triangles":14,"max_degree":18,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0045401","count":25},{"id":"GO:0045425","count":25},{"id":"GO:2000811","count":25},{"id":"GO:0050798","count":25},{"id":"GO:0048544","count":25}]},{"hash":"2274241866840839523","title":"Neuronal transcription and synaptic signaling","description":"This cluster combines neuronal gene regulation (DNA-templated transcription) with clear synaptic and neural signaling functions (ion transport, membrane potential regulation, neurotransmitter loading into vesicles, and fear-related behavior), suggesting a module where transcriptional control is linked to neuronal signaling. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0001662","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0035725","count":4}]},{"hash":"657237810761924653","title":"Ubiquitin-regulated protein degradation and SUMO pathways","description":"The cluster is dominated by GO terms tied to ubiquitination and related post-translational modifications (ubiquitin-dependent ERAD, deubiquitination, ubiquitin ligase regulation) as well as SUMOylation, with connections to signaling paths like NF-kappaB and TLR3. This suggests a cohesive module centered on protein fate control via ubiquitin/SUMO pathways and associated quality control, with some stress response links (heat) and telomere maintenance as ancillary associations.","confidence":"High","size":26,"edges":253,"triangles":1282,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0016579","count":5},{"id":"GO:0007253","count":4},{"id":"GO:0034140","count":4},{"id":"GO:0016925","count":4}]},{"hash":"562524631822927063","title":"Glycinergic neurotransmission and glycine transport","description":"Based on the top GO terms, the cluster is enriched for glycinergic synaptic activity (glycinergic transmission and regulation) and glycine import/transport, complemented by neural development terms and amino acid transport, suggesting a group of proteins involved in glycine handling and glycinergic signaling in neural contexts.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0021794","count":9},{"id":"GO:0060092","count":8},{"id":"GO:0042066","count":8},{"id":"GO:0036233","count":8},{"id":"GO:0021984","count":8}]},{"hash":"994982425586098066","title":"Developmental Regulation and Metabolic Pathways","description":"This cluster blends developmental processes (gastrulation, substantia nigra development, cell proliferation) with epigenetic regulation (histone methylation) and core metabolism (2-oxoglutarate and thiamine biosynthesis, glutamate production), plus neural-related membrane potential regulation. The convergence suggests proteins involved in developmental programs linked to metabolism and epigenetic control, rather than a single narrow function, yielding a Moderate confidence label.","confidence":"Medium","size":26,"edges":220,"triangles":1042,"max_degree":24,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043046","count":14},{"id":"GO:0008283","count":14},{"id":"GO:0051573","count":13},{"id":"GO:0021762","count":12},{"id":"GO:0007369","count":11}]},{"hash":"2007661866238916552","title":"Steroid Hormone Biosynthesis","description":"The strongest themes are several steroid-related biosynthetic processes (testosterone, estrogen, glucocorticoid) and androgen catabolic activity, pointing to a core cluster of proteins involved in steroid hormone production and turnover. Retinoid metabolism and pigment biosynthesis terms appear as secondary associations, but do not override the primary steroid biosynthesis signal.","confidence":"High","size":26,"edges":167,"triangles":315,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":18},{"id":"GO:0042574","count":15},{"id":"GO:0061370","count":15},{"id":"GO:0017000","count":15},{"id":"GO:0042438","count":15}]},{"hash":"2130057726584465047","title":"Steroid and Prostaglandin Biosynthesis in Reproductive Tissues","description":"The cluster is dominated by GO terms for steroid hormone biosynthesis (testosterone, cortisol), prostaglandin biosynthesis, and related cytochrome P450 pathways (omega-hydroxylase and epoxygenase). These links point to enzymes involved in hormone metabolism and lipid mediator production, often active in reproductive development (uterus, female gonad) and associated tissues. Although some terms touch broader processes, the strongest recurring theme is steroid and prostaglandin biosynthesis via P450 enzymes in reproductive contexts.","confidence":"High","size":26,"edges":6,"triangles":1,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048565","count":11},{"id":"GO:0033280","count":11},{"id":"GO:0001516","count":11},{"id":"GO:0060065","count":10},{"id":"GO:0008585","count":10}]},{"hash":"365460358846728097","title":"Innate Immune Activation and Toxin Response","description":"The top GO terms cluster around innate immune processes (innate immune response, LPS response, T cell activation) and cellular responses to toxins and xenobiotics (cadmium, chemical stimuli, drug exposure). While a few terms touch on cell cycle or pollen recognition, the predominant theme is immune signaling paired with stress/toxin responses, suggesting a cluster of proteins involved in initiating or modulating immune action under toxic or foreign stimulus.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071276","count":25},{"id":"GO:0045087","count":25},{"id":"GO:1901925","count":24},{"id":"GO:0045401","count":24},{"id":"GO:0045425","count":24}]},{"hash":"119519344089536695","title":"Interferon-Responsive Immune Signaling","description":"Top terms show strong emphasis on interferon-alpha and interferon-beta responses and general biotic-stimulus defense, suggesting an immune signaling core. Some terms touch on metabolism or development, but they are less central to the cluster\u2019s main theme. Therefore, this label captures the dominant functional signal in the group.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":4},{"id":"GO:0035455","count":4},{"id":"GO:0050884","count":4},{"id":"GO:0097091","count":4},{"id":"GO:0046597","count":4}]},{"hash":"1857900397327330530","title":"Multisystem Development and Signaling","description":"This cluster centers on developmental processes across tissues (brain, nervous system, kidney, mating projection) and signaling pathways (T cell receptor, ROBO), with supporting vesicle trafficking (Golgi to plasma membrane transport, synaptic vesicle exocytosis) and cell-cycle activity, suggesting a broad program coordinating development with intercellular communication. ","confidence":"Medium","size":26,"edges":138,"triangles":164,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0006893","count":7},{"id":"GO:0010796","count":7},{"id":"GO:2000300","count":7}]},{"hash":"2171739318723096638","title":"Cellular stress and inflammatory signaling","description":"This cluster is dominated by GO terms related to responses to stressors such as hydrogen peroxide and unfolded proteins, chaperone-mediated assembly, and inflammatory signaling (IL-6, TNF) with regulation of extrinsic apoptosis, suggesting a theme of stress- and immune-related signaling rather than a single, cohesive process. A few terms (cell division, atrial septum development, virion assembly) are less central, likely representing pleiotropic roles of proteins in the set.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":3},{"id":"GO:0051131","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006986","count":2},{"id":"GO:0071354","count":2}]},{"hash":"1018523521175089753","title":"Unknown","description":"The top terms are highly diverse, including immune cytokine production (IL-3, GM-CSF), T cell proliferation, LPS response, pollen recognition, and even plant- or neuro-related terms, with no clear common function. There are no edges or triangles connecting these proteins, suggesting they do not form a cohesive functional module. Without a unifying theme, the cluster cannot be confidently labeled beyond Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":25},{"id":"GO:0045401","count":25},{"id":"GO:0045425","count":25},{"id":"GO:0071222","count":25},{"id":"GO:2000811","count":25}]},{"hash":"1218046606397226567","title":"Endothelial Development and Lipoprotein Transport","description":"This cluster centers on endothelial cell proliferation, tight junction and extracellular matrix (fibronectin fibril organization) dynamics, and lipoprotein transport/clearance with cholesterol storage. The presence of anti-inflammatory regulation terms (negative regulation of IL-8 production and Th17 commitment) and zymogen activation suggests coordinated vascular remodeling and lipid handling with proteolytic activity. Overall, it represents an endothelial/matrix- and lipid-related functional module.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":24},{"id":"GO:0034381","count":23},{"id":"GO:2000483","count":23},{"id":"GO:0001935","count":23},{"id":"GO:1904274","count":23}]},{"hash":"166676719100030908","title":"Vascular inflammation and coagulation signaling","description":"This cluster centers on endothelial cell migration, inflammatory signaling (IL-1 response), complement activation (lectin pathway), and coagulation, with supporting roles for ERK signaling, protein secretion, and cell adhesion, suggesting a coordinated vascular inflammatory/remodeling program. The network metrics show no edges, indicating the terms reflect functional themes rather than a single protein complex.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035641","count":7},{"id":"GO:0043536","count":6},{"id":"GO:0044320","count":6},{"id":"GO:0043537","count":6},{"id":"GO:0070374","count":6}]},{"hash":"847538083563966922","title":"Ubiquitin-Dependent Protein Degradation and Signaling","description":"The top GO terms are largely about ubiquitination and ubiquitin-mediated proteolysis (including ubiquitin-dependent protein catabolic process, K6-linked ubiquitination, autoubiquitination, and ERAD) and their downstream signaling roles (TNF/NF-\u03baB pathways). Additional terms point to chromatin turnover (histone catabolic process) and immune system processes (V(D)J recombination), all tying back to ubiquitin-regulated protein turnover and signaling. This makes the core theme clearly centered on ubiquitin-mediated degradation and related signaling pathways.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0085020","count":15},{"id":"GO:0051865","count":15},{"id":"GO:0036205","count":15},{"id":"GO:1903265","count":15}]},{"hash":"291693734167739719","title":"Platelet Activation and Coagulation Network","description":"The top GO terms converge on platelet biology: activation, adhesion to the extracellular matrix, exocytosis (granule release), and coagulation/fibrin clot formation. Angiogenesis fits the vascular repair context, and negative regulation of platelet aggregation complements the hemostatic theme; while a few immune-related terms appear, they do not outweigh the core platelet/coagulation signal. Thus, the cluster most plausibly represents platelet activation and coagulation processes.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030168","count":8},{"id":"GO:0007160","count":8},{"id":"GO:0045921","count":8},{"id":"GO:0001525","count":8},{"id":"GO:0001867","count":7}]},{"hash":"1165397510268806516","title":"Retina development and photoreceptor GPCR signaling","description":"The top GO terms cluster around visual system development and signaling: visual perception, axonogenesis, opsin-mediated signaling, GPCR signaling activation, and activation of adenylate cyclase, which together point to retina/photoreceptor development and phototransduction pathways. Some cardiac-related terms are present but appear less central to the cluster\u2019s main theme, suggesting eye/vision signaling as the representative function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0007409","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0006469","count":5}]},{"hash":"727545528772140646","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The cluster is enriched for terms related to actin cytoskeleton organization (cortical actin, cortical actin cytoskeleton organization), cell-matrix adhesion, and substrate-dependent cell migration, with additional signals for microtubule localization and centrosome placement, all indicating coordinated cytoskeletal remodeling driving movement and adhesion. While some terms touch on mitosis, the dominant theme is cytoskeletal dynamics and migration.","confidence":"High","size":25,"edges":19,"triangles":4,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0006929","count":3},{"id":"GO:2000251","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0030866","count":3}]},{"hash":"124013282277615445","title":"Neural development and CNS signaling","description":"Top GO terms converge on nervous system development, CNS/brain development, and signaling pathways (Roundabout/ROBO and Smoothened/SHH), with regulation of synaptic vesicle exocytosis also represented, suggesting a neural development and synaptic signaling cluster. A few terms (kidney and heart development) are present but less central.","confidence":"High","size":25,"edges":263,"triangles":1571,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":10},{"id":"GO:0035385","count":9},{"id":"GO:0050852","count":9},{"id":"GO:0001822","count":9},{"id":"GO:0007224","count":9}]},{"hash":"968831446541504535","title":"Neurodevelopmental regulators","description":"Top GO terms point to neural development, including cerebral cortex GABAergic interneuron differentiation, spinal cord motor neuron fate specification, subpallium neuron fate commitment, and retina development, with additional nervous system\u2013related regulation terms. There is also a clear signal of transcriptional control, via transcription by RNA polymerase II and its negative regulation, suggesting these proteins act as transcriptional regulators shaping neural development. While there are a few broader developmental terms (osteoblast, endocrine pancreas, bronchiole development), the neural-developmental and transcriptional themes are dominant, supporting this label.","confidence":"Medium","size":25,"edges":298,"triangles":2254,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0002076","count":10},{"id":"GO:0002087","count":10},{"id":"GO:0060041","count":10},{"id":"GO:0000122","count":9}]},{"hash":"9555855297939162","title":"Platelet-driven wound healing and ECM remodeling","description":"The cluster is enriched for platelet activation, platelet aggregation, wound healing, and cell-matrix adhesion, indicating a core function in hemostasis and tissue repair with extracellular matrix interactions. Developmental terms and complement activation suggest additional signaling contexts but do not override the dominant wound-healing theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0030168","count":7},{"id":"GO:0021983","count":6},{"id":"GO:0007160","count":6},{"id":"GO:0001867","count":6}]},{"hash":"1460031547394355972","title":"Vertebrate Organogenesis","description":"The top GO terms cluster around developmental processes across multiple organs and tissues (pituitary, midbrain, pancreas, bone, cartilage, heart, cranial skeleton, glia, uterus), indicating a shared theme of embryonic organogenesis and tissue differentiation in vertebrates. There\u2019s no single pathway dominating, but a clear focus on developmental specification across organs, so a broad organogenesis label is appropriate.","confidence":"Medium","size":25,"edges":23,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":9},{"id":"GO:0000122","count":8},{"id":"GO:0003148","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0002076","count":7}]},{"hash":"560319750004955251","title":"Developmental and Immune Signaling","description":"The top terms include innate immune response and multiple signaling pathways (insulin receptor signaling, growth hormone receptor signaling, integrin-mediated signaling) along with development-related processes (forebrain and heart development, mammary gland morphogenesis) and transcription. This suggests the proteins participate in broad signaling crosstalk linking immunity, metabolism, and development rather than a single narrow function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0008285","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0060396","count":3}]},{"hash":"1057090237629636646","title":"Mitochondrial Metabolism and Protein Import","description":"The cluster is centered on mitochondrial-related processes: protein import into the mitochondrial matrix, anaerobic respiration, and cellular oxidant detoxification, with supporting links to folate metabolism and broader metabolic/detox pathways. Some terms reflect stress or signaling responses (lipopolysaccharide response, morphine/D-serine signaling) that can accompany metabolic states. Together, these terms suggest a mitochondria-focused metabolic and redox balance module.","confidence":"Medium","size":25,"edges":299,"triangles":2277,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0009061","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0046653","count":2},{"id":"GO:0098869","count":2}]},{"hash":"1667671093266419028","title":"Oxidative DNA Damage Response and Apoptosis","description":"This cluster centers on GO terms related to apoptotic process, response to oxidative stress (hydrogen peroxide), base-excision repair, and DNA-related catabolic activity, suggesting a coherent theme of cellular response to oxidative DNA damage, with repair pathways and programmed cell death acting as outcomes. The presence of a skin-related term (corneocyte development) is less central and may reflect broader tissue-related roles or annotation noise.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0070301","count":4},{"id":"GO:0090502","count":4},{"id":"GO:0006284","count":4},{"id":"GO:0042493","count":4}]},{"hash":"60485830062574458","title":"Sensory Perception and Stimulus-Response Signaling","description":"The top GO terms cluster around sensory perception (pain, vision, visual learning) and responses to stimuli (temperature, prostaglandin, cocaine), plus signaling pathways (ERK cascade). While some terms like heart development or thermogenesis are less directly tied, the overall pattern favors proteins involved in sensory signaling and stimulus-induced behavioral responses.","confidence":"Medium","size":25,"edges":142,"triangles":219,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0007601","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0010759","count":14},{"id":"GO:0070374","count":14}]},{"hash":"2135581384110342589","title":"GPCR-cAMP Signaling and Metabolism","description":"The top GO terms cluster around GPCR signaling that activates adenylate cyclase and affects membrane potential, tying into energy balance and cardiovascular regulation (thermogenesis, BP control) and mitochondrial energy production (electron transport chain). Rho signaling and temperature response further align with GPCR-initiated cascades. A couple of terms (pain perception, nipple morphogenesis) are less central but can intersect with broad signaling networks, so the dominant theme remains GPCR-cAMP\u2013driven metabolic and signaling control.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":24},{"id":"GO:0010579","count":24},{"id":"GO:0022900","count":24},{"id":"GO:0071502","count":23},{"id":"GO:0042391","count":23}]},{"hash":"767801197556673835","title":"Neural Development and Synapse Assembly","description":"This cluster centers on neural development and synaptic formation/signaling, with prominent terms for synapse assembly/organization, nerve impulse transmission, and peripheral nervous system development, plus Hedgehog/Smoothened signaling. While there are a few broader developmental terms (angiogenesis, myoblast differentiation, innate immune response), the dominant theme ties to neural connectivity establishment and signaling.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0007224","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0045663","count":3},{"id":"GO:0045087","count":3}]},{"hash":"434035570059463820","title":"Negative regulators of signaling and cell cycle","description":"This cluster is dominated by GO terms describing negative regulation across key signaling pathways (MAPK/ERK, PI3K/AKT), cell-cycle control (cyclin-dependent kinases and kinetochore localization), and synaptic/adhesion-related processes (postsynaptic density assembly, synaptic vesicle clustering). The unifying theme is proteins that inhibit or modulate signaling cascades and structural assembly in diverse cellular contexts, suggesting a cohesive set of regulatory proteins rather than executors. ","confidence":"Medium","size":25,"edges":265,"triangles":1615,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045736","count":14},{"id":"GO:0034501","count":14},{"id":"GO:0070373","count":12},{"id":"GO:0050860","count":12},{"id":"GO:0000200","count":12}]},{"hash":"2215550084186531002","title":"Neural development and synapse formation","description":"This cluster's top GO terms are dominated by nervous system development, pyramidal neuron differentiation, axon guidance, and synapse assembly, with cell-adhesion terms suggesting neural connectivity. While there are a few broad developmental terms (heart development, angiogenesis), the recurring neural-related terms strongly indicate neuronal differentiation and synaptogenesis as the cluster's core function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0007507","count":4}]},{"hash":"331737526767105853","title":"Developmental and Innate Immune Proteins","description":"The top GO terms span development (angiogenesis, limb development, multicellular organism development) and innate immune processes (innate immune response, phagolysosome assembly), with additional cues from cell division and synaptic development. This suggests a broad cluster of proteins involved in organismal development and immune-related remodeling, rather than a single tight pathway. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007275","count":3}]},{"hash":"2242102591180752790","title":"Immune cell differentiation and signaling","description":"The cluster is enriched for immune-related GO terms, including B cell receptor signaling, TH2 differentiation, NK cell differentiation, and lamellocyte differentiation, indicating a shared theme of immune cell development and signaling; other terms touch on related signaling and developmental processes, but the immune terms appear to drive the overall functional theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050853","count":6},{"id":"GO:0035773","count":5},{"id":"GO:0045630","count":5},{"id":"GO:0035171","count":5},{"id":"GO:0032825","count":5}]},{"hash":"1291528613737218959","title":"Mitochondrial translation machinery","description":"The cluster is dominated by GO terms related to mitochondrial protein synthesis: translation, tRNA processing, ribosome biogenesis, and mitochondrial-specific tRNA aminoacylation (for valine, tyrosine, and tryptophan). These collectively point to the mitochondrial translation system and ribosome assembly, even though a few other terms (e.g., vasculogenesis) appear at lower frequency. The lack of interactions does not detract from this coherent mitochondrial translation theme. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0008033","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0070183","count":3}]},{"hash":"1502538512071352145","title":"Cell adhesion and tissue development","description":"The cluster is dominated by GO terms for cell-matrix and cell-cell adhesion, plus nervous system development and synapse assembly, suggesting proteins involved in adhesion-mediated organization and development of neural and other tissues. The presence of organ/tissue development signals (e.g., lung mesenchyme) and related growth/hormone regulation terms supports a broad theme of structural cell interactions guiding tissue formation. Overall, the proteins seem linked by adhesion-driven tissue development functions rather than a single specific pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007160","count":8},{"id":"GO:0007157","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0014068","count":8},{"id":"GO:0045087","count":8}]},{"hash":"227751103953307451","title":"Unknown","description":"The top GO terms span neural signaling, autonomic cardiovascular regulation, and broader physiological processes, but also include unrelated terms like viral release and nipple morphogenesis, giving no single cohesive function for the cluster.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007195","count":5},{"id":"GO:0019076","count":5},{"id":"GO:0051209","count":5},{"id":"GO:0042552","count":5},{"id":"GO:0060658","count":4}]},{"hash":"365952069895006009","title":"Angiogenesis and ECM remodeling in inflammation","description":"The top GO terms cluster around vascular biology and extracellular matrix remodeling in an inflammatory context: collagen fibril organization, fibrinolysis, angiogenesis, endothelial cell survival, platelet regulation, and inflammatory signaling such as interleukin-1 response. The combination suggests a module governing blood vessel formation and ECM remodeling during immune responses rather than a single enzyme activity.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":14},{"id":"GO:1902042","count":13},{"id":"GO:0002250","count":13},{"id":"GO:0042730","count":13},{"id":"GO:2000352","count":13}]},{"hash":"1060804491878802163","title":"Inflammation and coagulation regulation","description":"The top GO terms cluster around cytokine responses (interleukin-6 and interleukin-1), coagulation and platelet regulation, complement activation, and vascular functions (vasoconstriction, angiogenesis regulation). This suggests a coordinated inflammatory-vascular-hemostatic program, with occasional stress responses (UV-B, NMJ remodeling) that may reflect broader cellular stress contexts but do not override the central theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045907","count":8},{"id":"GO:1902042","count":8},{"id":"GO:0071354","count":8},{"id":"GO:0016525","count":8},{"id":"GO:0001867","count":7}]},{"hash":"1625869004312739889","title":"Neuronal Development and Vesicle Trafficking","description":"The cluster is characterized by GO terms centered on nervous system development and dendritic spine formation, with roles in regulated exocytosis and intracellular transport. The inclusion of small GTPase-mediated signaling and endosome/melanosome transport points to coordination between neural differentiation and vesicle trafficking/synaptic vesicle dynamics, making this a cohesive neural development plus transport cluster. Some cell cycle terms may reflect shared components rather than a core theme, but the dominant signal is neural development with vesicle transport.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0051301","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0060999","count":6},{"id":"GO:0034629","count":6}]},{"hash":"1744658836870070088","title":"Histone modification and transcription regulation","description":"The top GO terms mainly point to histone modifications (H3K4me3/2, H3K27/H3K14/H3K36 acetylation, H4 acetylation) and transcription-related processes, suggesting this cluster groups chromatin-regulating proteins that modulate gene expression. The presence of development-related terms like ovarian follicle development and imaginal disc-derived wing vein specification supports a link to chromatin regulators guiding developmental gene expression. Some terms are marked obsolete, but the overall theme is chromatin modification influencing transcription during development.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":2},{"id":"GO:0001541","count":2},{"id":"GO:1901674","count":2},{"id":"GO:0044648","count":2},{"id":"GO:2001040","count":2}]},{"hash":"2047423377486619862","title":"Innate Immune Activation and CCL5 Production","description":"The strongest signals come from innate immune response and positive regulation of CCL5 production, suggesting these proteins cluster around promoting chemokine-mediated innate defense. While some terms relate to broader processes (e.g., NF-kappaB regulation, responses to mechanical stimuli), the central theme is innate immunity and CCL5 chemokine production, making this a coherent label for the group.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0071651","count":7},{"id":"GO:0045087","count":6},{"id":"GO:0033160","count":6},{"id":"GO:0072660","count":5},{"id":"GO:0035994","count":5}]},{"hash":"682229005467718205","title":"Angiogenesis and endothelial migration","description":"Proteins in this cluster are enriched for angiogenesis and endothelial cell migration, including positive regulation of angiogenesis, endothelial cell migration, and cell-matrix adhesion, with ERK signaling involvement. Immune-related terms are present but secondary, suggesting a primary theme of vascular remodeling and associated signaling.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0043536","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0045766","count":4}]},{"hash":"643048060391705308","title":"Neural and sensory organ development","description":"The top terms cluster around neural connectivity and sensory structure formation: axonal fasciculation, myelination, and synapse assembly point to nervous system development, while lens fiber cell differentiation and otolith morphogenesis indicate eye and inner ear (sensory organ) development. Innate immune responses and cytokine production appear as ancillary terms, not central to the main theme. Thus, a concise label capturing neural and sensory organ development fits best. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901838","count":2},{"id":"GO:0000288","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0045087","count":2}]},{"hash":"389871083542056539","title":"Collagen fibril organization and tissue development","description":"This cluster centers on extracellular matrix remodeling and developmental processes, highlighted by collagen fibril organization, skin and heart development, and regulation of angiogenesis and BMP signaling. The presence of related regulatory pathways (GTPase activity, NO signaling) suggests a cohesive theme of ECM-driven tissue development and growth control, even though there are no observed protein\u2013protein interactions in the graph. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030199","count":6},{"id":"GO:0016525","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0038095","count":4},{"id":"GO:0043547","count":4}]},{"hash":"481367346969903860","title":"Neural development and embryogenesis","description":"Top GO terms indicate strong emphasis on developmental processes, especially neural development (forebrain development, neural tube closure) and general multicellular organism development, along with related processes like skeletal system development and mitotic cell cycle/DNA-templated transcription. Some terms reflect stress-induced apoptosis and defense responses that may be auxiliary or incidental, but the core theme is embryonic neural formation and development. ","confidence":"Medium","size":24,"edges":19,"triangles":11,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:0006349","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0030900","count":4}]},{"hash":"826718402866867066","title":"Nucleolar ribosome biogenesis and RNA processing","description":"The proteins show strong representation of ribosome biogenesis, rRNA and snRNA pseudouridine synthesis, rRNA maturation and processing, and telomerase RNA localization to Cajal bodies, all of which point to a nucleolar/RNP maturation theme. A single term related to dendrite development is present but does not override the core RNA-centric signals.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0007049","count":2},{"id":"GO:1904874","count":1},{"id":"GO:0031118","count":1},{"id":"GO:0031120","count":1}]},{"hash":"55405892999228026","title":"Neural development and axon guidance","description":"The top GO terms cluster around neural development and connectivity: projection neuron axonogenesis, motor neuron axon fasciculation, and regulation of developmental growth, suggesting a coherent theme of neural maturation and pathfinding. Immune-related terms (cytokine production and T cell proliferation) appear among the top terms, which may reflect cross-talk or annotation overlap rather than a core function of this cluster; overall, it seems best described as neural development with axon guidance.","confidence":"Medium","size":24,"edges":68,"triangles":104,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045401","count":23},{"id":"GO:0045425","count":23},{"id":"GO:2000811","count":23},{"id":"GO:0050798","count":23},{"id":"GO:0048544","count":23}]},{"hash":"1772753401682469272","title":"Ribosome Translation and Neuronal Signaling","description":"The cluster is dominated by GO terms for translation and ribosome biogenesis, indicating a core set of proteins involved in protein synthesis. There is also a notable enrichment for neural-related processes (synaptic transmission and neuron projection development), suggesting a secondary theme of neuronal signaling or regulation. The presence of transcription-related and obsolete terms likely reflects annotation noise, but the strongest cohesive signal centers on translation machinery, with neural signaling as a secondary facet.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0051968","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0010976","count":3}]},{"hash":"375557207915192163","title":"Mitosis and nuclear transport","description":"GO terms are dominated by mitotic processes (sister chromatid separation, DNA replication, mitotic nuclear membrane reassembly) and nuclear import (NLS-bearing protein import into nucleus), pointing to a cell-cycle\u2013related cluster with a focus on nuclear functions. Supporting signals include positive regulation of GTPase activity and vesicle trafficking, but the main theme centers on mitosis and nuclear transport.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051306","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006607","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0006260","count":5}]},{"hash":"200221106715578033","title":"Neuronal Signaling and Synaptic Regulation","description":"The top GO terms are dominated by neuronal and synaptic functions: positive regulation of glutamatergic synaptic transmission, synaptic vesicle uncoating, cellular responses to nerve growth factor, and PKC activation, all pointing to synaptic signaling and neuronal communication. Other terms like adaptive immune response or chromatin organization appear less central, suggesting they are less representative of the core cluster function. Overall, the core theme seems to be neuronal signaling and synaptic regulation.","confidence":"Medium","size":24,"edges":55,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":5},{"id":"GO:0010923","count":5},{"id":"GO:0002250","count":5},{"id":"GO:0051968","count":5},{"id":"GO:0086098","count":4}]},{"hash":"2123973662301434971","title":"Unknown","description":"The GO terms span cell cycle and genome mobility (DNA transposition, DNA integration, proviral latency) alongside RNA editing and diverse metabolic processes, with no single cohesive function tying the set together. This dispersion makes a specific, representative label unlikely. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0006382","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0006313","count":2}]},{"hash":"706005200040276802","title":"Actin cytoskeleton remodeling and membrane protrusions","description":"The top GO terms cluster around actin filament polymerization, actin cytoskeleton organization, filopodium and ruffle assembly, and crosslinking, indicating remodeling of the actin network and formation of membrane protrusions. Some insulin signaling and excitatory postsynaptic potential terms appear, but the dominant theme is actin dynamics.","confidence":"High","size":24,"edges":12,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030838","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0046626","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0051017","count":4}]},{"hash":"605808466322598899","title":"Tissue development and immune/inflammatory responses","description":"The top GO terms cluster around tissue- and organ- development (nipple morphogenesis, metanephric glomerulus development, ovarian follicle growth, lung connective tissue development) together with immune/inflammatory processes (inflammatory response, immune response) and related signaling. This suggests the proteins collectively relate to developmental roles across tissues with concurrent involvement in immune or inflammatory contexts, rather than a single classic pathway. Therefore a label capturing tissue development plus immune/inflammatory functions fits best.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060658","count":4},{"id":"GO:0032962","count":4},{"id":"GO:0072224","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0001545","count":4}]},{"hash":"1114299721982874996","title":"GPCR Signaling and Ion Transport","description":"The cluster is dominated by GPCR-related signaling terms (intracellular signal transduction; G protein-coupled receptor signaling; adenylate cyclase-inhibiting GPCR pathway) and related ion flux processes (sodium transmembrane transport; GABA signaling; umami taste). This points to a cohesive group of proteins involved in GPCR-driven signal transduction that modulates second messengers and ion channels, with ancillary links to immune signaling and development terms.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0038042","count":3},{"id":"GO:0007196","count":3},{"id":"GO:0003380","count":3}]},{"hash":"2217127350341872933","title":"Amino acid catabolism and cofactor biosynthesis","description":"The terms cluster around degradation of several amino acids (alanine, kynurenine/tryptophan, glycine) and biosynthetic pathways for cofactors (pyridoxine/B6, quinolinate/NAD), plus Fe-S cluster assembly and related metabolic processes, suggesting a metabolic module centered on amino-acid turnover and cofactor biosynthesis. The Notch signaling term seems out of place and may be incidental. ","confidence":"Medium","size":24,"edges":271,"triangles":1915,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":14},{"id":"GO:0007219","count":14},{"id":"GO:0097053","count":14},{"id":"GO:0019265","count":13},{"id":"GO:0019442","count":13}]},{"hash":"1740211896448663550","title":"Complement-Coagulation-Platelet Axis","description":"The GO terms show strong representation of complement activation (lectin pathway), blood coagulation and fibrin clot formation, and platelet aggregation/regulation, alongside related immune/inflammatory signals (IL-1 response) and apoptotic cell recognition. This clustering suggests a core theme around hemostasis and innate immune activation with platelet involvement, so naming it the Complement-Coagulation-Platelet Axis reflects the dominant functional group in the cluster.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":13},{"id":"GO:0072378","count":9},{"id":"GO:0007160","count":9},{"id":"GO:0050714","count":9},{"id":"GO:0071347","count":8}]},{"hash":"393821208323561621","title":"Ribosome Biogenesis and Translation","description":"The top terms emphasize translation (cytoplasmic translation) and ribosome biogenesis (including small subunit biogenesis), indicating these proteins are part of the ribosome assembly and protein synthesis machinery; occasional cell cycle terms likely reflect coordination with growth rather than a separate pathway.","confidence":"High","size":24,"edges":234,"triangles":1247,"max_degree":23,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0006400","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0002181","count":6},{"id":"GO:0007049","count":6}]},{"hash":"1814933621792018156","title":"Immune Activation and Cytokine Production","description":"Most of the top GO terms describe immune signaling and cytokine production, e.g., positive regulation of interleukin-3 and granulocyte macrophage colony-stimulating factor production, cellular response to lipopolysaccharide, and activated T cell proliferation. While a few terms touch on cell cycle or development, the dominant theme is immune activation and inflammatory signaling, making this label representative for the cluster.","confidence":"High","size":24,"edges":89,"triangles":121,"max_degree":17,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":24},{"id":"GO:0045401","count":24},{"id":"GO:0045425","count":24},{"id":"GO:0071222","count":24},{"id":"GO:2000811","count":24}]},{"hash":"515143864202269304","title":"Eye Morphogenesis and Neural/Synaptic Development","description":"This cluster features strong signals for eye development (retina/camera-type eye development and embryonic eye morphogenesis) and neuronal/synaptic maturation (postsynaptic membrane assembly, cytoskeletal organization at the active zone, and acetylcholine catabolism in the synaptic cleft), suggesting a shared role in sensory organ formation linked to synaptic function. While some terms concern other developmental processes (osteoblast and lung morphogenesis), the dominant pattern points to eye morphogenesis with neural/synaptic involvement.","confidence":"Medium","size":24,"edges":235,"triangles":1277,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":12},{"id":"GO:0002076","count":11},{"id":"GO:0002087","count":11},{"id":"GO:0006366","count":9},{"id":"GO:0060441","count":7}]},{"hash":"551006498177449886","title":"Heart, muscle, and neural development","description":"Based on GO terms such as heart development, angiogenesis, myoblast fusion, ossification, and neural signaling, the proteins appear linked to broad developmental processes across cardiac, skeletal, and nervous systems, with shared signaling (Rho-related) regulation. The label emphasizes this common developmental theme rather than a single function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0035023","count":7},{"id":"GO:0001525","count":6},{"id":"GO:0019226","count":6},{"id":"GO:0007275","count":6}]},{"hash":"1670216246020063116","title":"Inflammation, Angiogenesis, and Coagulation Signaling","description":"The cluster includes apoptosis recognition and regulation, IL-1\u2013mediated inflammatory responses, complement activation, angiogenesis, exocytosis, coagulation and platelet regulation, plus UV-B response and NMJ axon regeneration. Together these terms point to a cohesive theme of tissue injury response connecting immune signaling, vascular remodeling, and hemostasis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0043654","count":13},{"id":"GO:1902042","count":13},{"id":"GO:0045921","count":13},{"id":"GO:0001525","count":13},{"id":"GO:0001867","count":12}]},{"hash":"743298211025647406","title":"Cytochrome P450-driven steroid and xenobiotic metabolism","description":"This cluster centers on cytochrome P450 pathways (omega-hydroxylase and epoxygenase P450), with multiple terms for steroid biosynthesis (testosterone, cortisol, bile acids) and xenobiotic/alkaloid metabolism (carbazole, organofluorine regulation). The recurring P450 theme links the diverse GO terms, suggesting a coherent role in endogenous steroid production and detoxification/metabolism of xenobiotics.","confidence":"High","size":24,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097267","count":17},{"id":"GO:0019373","count":17},{"id":"GO:0061370","count":17},{"id":"GO:0009822","count":17},{"id":"GO:0034651","count":17}]},{"hash":"761868911206869592","title":"Unknown","description":"The terms span immune/inflammatory regulation, ubiquitination, and signaling, but also DNA replication and RNA splicing, with no single cohesive function tying all terms together. This suggests the proteins have diverse regulatory roles rather than a unified pathway, so a specific label is not supported.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1350758277153366087","title":"Unknown","description":"The Top Terms span telomere maintenance (telomerase regulation and capping), adipocyte differentiation, cell cycle control, migration, RNA processing, immune defense, and mechanotransduction responses. The terms do not point to a single coherent pathway; they cover multiple unrelated cellular processes, suggesting a mixed or heterogeneous cluster. Therefore no specific functional label fits reliably.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032212","count":7},{"id":"GO:0045444","count":7},{"id":"GO:1904355","count":7},{"id":"GO:0045736","count":7},{"id":"GO:0016477","count":7}]},{"hash":"1494717299954605065","title":"DNA damage response and apoptosis regulation","description":"The dominant terms describe DNA damage response and apoptosis, including regulation of DNA damage checkpoints, attachment of DNA breaks to the nuclear envelope, and intrinsic apoptotic signaling in response to DNA damage, with supporting terms for DNA damage tolerance via translesion synthesis and protein sumoylation. A few terms relate to meiosis, keratinocytes, or hormone signaling and are less representative, so the label reflects the core DDR/apoptosis theme.","confidence":"Medium","size":24,"edges":40,"triangles":15,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043060","count":1},{"id":"GO:1904290","count":1},{"id":"GO:0045838","count":1},{"id":"GO:0033235","count":1},{"id":"GO:1990683","count":1}]},{"hash":"1009368007529343809","title":"Neuro-immune development signaling","description":"The top GO terms point to neural development and synaptic signaling (nervous system development, brain development, regulation of synaptic vesicle exocytosis, smoothened signaling) alongside immune-related signaling (T cell receptor signaling, neutrophil clearance, STAT phosphorylation), suggesting a cluster centered on developmental signaling that spans neural and immune contexts.","confidence":"Medium","size":24,"edges":194,"triangles":681,"max_degree":22,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0043552","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0042517","count":7}]},{"hash":"387639954709838633","title":"Unknown","description":"The GO terms are diverse and there is no single dominant function linking the proteins (immune-related terms, detoxification, transcription, and various developmental processes). The network has no edges or clustering structure, suggesting this is a heterogeneous set rather than a cohesive functional module. Confidence: None","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0042742","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042102","count":2}]},{"hash":"769111454810333907","title":"Unknown","description":"The top GO terms span immune responses (innate and adaptive), bone development, insulin signaling, chromatin organization, and various signaling pathways, with no single dominant function tying the cluster together. There isn\u2019t a cohesive, core process to label, so the cluster is Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0060348","count":5},{"id":"GO:0002250","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0006348","count":4}]},{"hash":"2219952606788088764","title":"Viral assembly and egress via host endosomal pathway","description":"Based on the GO terms, the cluster centers on viral processes such as capsid secondary envelopment and release from host cells, and the involvement of endosomal sorting/MVB pathways and general protein trafficking. This suggests these proteins work together in assembling viral particles and mediating their egress by hijacking host endosomal trafficking. Some terms related to signaling or neuronal processes appear secondary, but the dominant pattern is viral assembly and exit.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046745","count":4},{"id":"GO:0009838","count":4},{"id":"GO:0048672","count":4},{"id":"GO:0019076","count":4},{"id":"GO:0032511","count":4}]},{"hash":"476009699838033026","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071037","count":3},{"id":"GO:0036450","count":3},{"id":"GO:0071051","count":3},{"id":"GO:0071035","count":3},{"id":"GO:0071040","count":3}]},{"hash":"2051131753294578157","title":"Diverse Metabolic Processes","description":"The top GO terms span a range of metabolic activities, including catabolic and biosynthetic pathways for steroids, vitamins (phylloquinone, retinal/retinoid), and small molecules, as well as broader developmental terms like lung development and sporulation. There isn\u2019t a single cohesive function tying all terms together, suggesting the cluster represents a mix of diverse metabolic pathways rather than a specific process.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042208","count":3},{"id":"GO:0008207","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0042574","count":3}]},{"hash":"96035804803121273","title":"Unknown","description":"The top GO terms cover apoptosis, heart development, auditory perception, B cell homeostasis, vesicle trafficking, glucose transport regulation, signaling, neutrophil degranulation, synaptic vesicle budding, and acrosome reaction, with no single cohesive process tying them together. This heterogeneity suggests no interpretable shared function for the cluster, or artifacts from the re-added proteins, so a specific, representative label cannot be assigned. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097194","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0001782","count":4},{"id":"GO:0006888","count":3}]},{"hash":"723163334806636588","title":"Immune Activation and Leukocyte Trafficking","description":"These proteins cluster around immune signaling and cell movement: strong GO terms for leukocyte tethering/rolling, Fc-gamma receptor signaling, complement activation, and responses to fungal origin indicate activation of innate and adaptive immunity. The presence of platelet activation and vascular/lymphatic development terms (lymph vessel morphogenesis, metanephric development) suggests coupling of inflammation with vascular remodeling. While a few terms relate to cartilage condensation and kidney development, the predominant pattern points to immune coordination and leukocyte recruitment.","confidence":"Medium","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":24},{"id":"GO:0010572","count":23},{"id":"GO:0001502","count":23},{"id":"GO:0072218","count":22},{"id":"GO:2000502","count":22}]},{"hash":"180598262415416575","title":"Ubiquitin-Dependent Protein Degradation and Immune Signaling","description":"The cluster is dominated by ubiquitination-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, K6-linked ubiquitination, histone catabolic process), suggesting primary involvement in protein turnover via the ubiquitin-proteasome system. Additional terms point to innate immune responses and TNF signaling, indicating a link between ubiquitination and immune signaling pathways. Some circadian and chromatin-related terms may reflect regulatory roles or shared components, but the strongest signal is ubiquitin-mediated degradation with immune pathway associations.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:0051865","count":11},{"id":"GO:1903265","count":10},{"id":"GO:0085020","count":10},{"id":"GO:0036205","count":10}]},{"hash":"1467565882860087846","title":"Developmental cell signaling and adhesion","description":"This cluster centers on cellular communication and adhesion during development, evidenced by ROBO/axon guidance, heterophilic cell-cell adhesion, myelination, and myoblast differentiation terms. Some immune and cardiac terms are present but the dominant theme is signaling and adhesion guiding tissue development.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0042552","count":5},{"id":"GO:0002377","count":4}]},{"hash":"1356209115711163286","title":"Neuronal excitability and sensory-driven behavior","description":"The cluster is enriched for ion transport (Ca2+, Na+, K+) and GABA signaling, plus excitatory postsynaptic potential and behavior-related terms (startle response, locomotion, sound perception, conditioned taste aversion) and circadian sleep regulation, indicating a cohesive theme of neuronal signaling governing stimulus-driven behavior.","confidence":"High","size":23,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":17},{"id":"GO:0071805","count":17},{"id":"GO:0001964","count":16},{"id":"GO:0045188","count":16},{"id":"GO:0035725","count":15}]},{"hash":"1386501949961785304","title":"Adrenergic Regulation of Blood Pressure","description":"The cluster is dominated by terms tied to cardiovascular homeostasis, including positive regulation of blood pressure, norepinephrine-epinephrine vasoconstriction, renal sodium excretion, and GPCR signaling activating adenylate cyclase. These point to adrenergic signaling controlling vascular tone and kidney function, suggesting the proteins participate in blood pressure regulation. Some terms like electron transport or development appear but do not define the main theme. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0035025","count":17},{"id":"GO:0060658","count":16}]},{"hash":"321871205204875308","title":"Coagulation, fibrinolysis, and angiogenesis","description":"The top GO terms are dominated by coagulation and fibrinolytic processes (complement activation via lectin pathway, fibrin clot formation, plasminogen activation, fibrinolysis) and vascular remodeling (positive regulation of angiogenesis) with associated cell-surface localization, suggesting a cluster of extracellular/coagulation-related proteins involved in blood clotting and blood vessel dynamics. Some terms like IL-1 response or NMJ-related regeneration appear ancillary rather than central.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":14},{"id":"GO:0072378","count":14},{"id":"GO:0031639","count":14},{"id":"GO:0045766","count":14},{"id":"GO:0034394","count":14}]},{"hash":"753287837549453971","title":"Developmental signaling and differentiation","description":"The top GO terms point to broad regulatory and developmental roles, including transcription (DNA-templated), differentiation (keratinocyte differentiation, dendrite morphogenesis), growth control (HIPPO signaling, negative regulation of cardiac muscle cell proliferation), apoptosis, and cell movement (chemotaxis). This suggests a cluster of proteins coordinating gene expression with signaling, survival, and tissue remodeling during development and differentiation.","confidence":"Medium","size":23,"edges":44,"triangles":33,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0006935","count":10},{"id":"GO:0006813","count":10},{"id":"GO:0048813","count":9},{"id":"GO:0043552","count":9}]},{"hash":"136446099072954793","title":"DNA maintenance and stress response","description":"The top GO terms are dominated by nuclear genome maintenance: DNA replication, DNA repair, and DNA-templated transcription, suggesting a core role in genome maintenance. The presence of apoptosis and cellular responses to virus and lipopolysaccharide indicates stress signaling and innate responses, with additional development-related terms (heart/placenta development, axonogenesis) that may reflect broader roles or annotation spillover. Overall, the cluster appears centered on DNA maintenance with related stress and developmental signaling contexts.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0006915","count":6},{"id":"GO:0006281","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0006351","count":5}]},{"hash":"2215098265601383559","title":"Proteoglycan glycosaminoglycan biosynthesis","description":"The top GO terms center on proteoglycan/glycosaminoglycan biosynthetic processes (heparan sulfate, chondroitin sulfate, keratan sulfate), suggesting the proteins cluster around proteoglycan biosynthesis. A spread of other metabolic terms appears, but the proteoglycan biosynthesis signal dominates. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":8},{"id":"GO:0030206","count":8},{"id":"GO:0018146","count":6},{"id":"GO:0098703","count":5},{"id":"GO:0006711","count":5}]},{"hash":"1934741138628499436","title":"Mitochondrial apoptosis in neurons","description":"Most terms point to mitochondrial-dependent apoptosis in neural cells: cytochrome c release, regulation of mitochondrial depolarization, neuron apoptotic process, and signaling that modulates cytochrome c release. Also, cellular response to hypoxia and calcium release support a stress-response axis. The retina development term is plausibly part of neural tissue context, so the label captures the main theme: neuronal mitochondrial apoptosis under stress.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0001662","count":2},{"id":"GO:0051281","count":2},{"id":"GO:2001240","count":2},{"id":"GO:0071456","count":2}]},{"hash":"250793178848177001","title":"Neuronal mRNA processing and translation control","description":"The top GO terms cluster around regulation of translation initiation and preinitiation complex formation, plus mRNA processing and spliceosome-mediated mRNA splicing, with a broader neuronal context suggested by synapse assembly and cocaine response terms. This points to a functional module that ties RNA metabolism and control of protein synthesis to synaptic development and neuronal signaling, rather than to a singular, isolated process.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0075525","count":3}]},{"hash":"1348100841447115893","title":"Steroid and retinoid biosynthesis","description":"This cluster is dominated by GO terms tied to biosynthetic and metabolic pathways for steroids (testosterone, androgens, estrogens, glucocorticoids) and retinoids (retinol, retinal), along with related pigment biosynthesis (melanin) and a developmental connection (lung development). The recurring theme is production and metabolism of lipid-derived signaling molecules, especially steroid hormones and retinoids, with other terms supporting these pathways. The obsolete oxidation-reduction term is ignored in interpreting the core function. Confidence: High","confidence":"","size":23,"edges":226,"triangles":1267,"max_degree":22,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":18},{"id":"GO:0042574","count":17},{"id":"GO:0061370","count":17},{"id":"GO:0017000","count":17},{"id":"GO:0042438","count":17}]},{"hash":"1502361683006430857","title":"Unknown","description":"The GO terms show a mix of plant-specific metabolic processes (raffinose family oligosaccharide biosynthesis, gibberellic acid signaling, diacylglycerol catabolic, cholesterol biosynthesis) and neural/retinal processes (negative regulation of synaptic transmission, learning, retina development, synapse organization). This broad, heterogeneous mix across distinct biology contexts provides no single coherent function to name the cluster, so Unknown is appropriate.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010325","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0042136","count":5},{"id":"GO:0006695","count":5},{"id":"GO:0009939","count":5}]},{"hash":"2058983682982563243","title":"Glycosaminoglycan biosynthesis and hormone/xenobiotic metabolism","description":"Medley of metabolic processes tied to sulfated proteoglycans (heparan/chondroitin/dermatan sulfate) biosynthesis alongside hormone and xenobiotic metabolism (estrogen catabolism, catecholamine/bile acid metabolism, angiotensin regulation). The co-occurrence of glycosaminoglycan biosynthesis with broad molecular metabolism suggests a cluster representing ECM component synthesis plus detox/hormone processing functions, with some developmental context (embryonic neurocranium morphogenesis).","confidence":"Medium","size":23,"edges":23,"triangles":1,"max_degree":22,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0015015","count":15},{"id":"GO:0030206","count":15},{"id":"GO:0006711","count":11},{"id":"GO:0002002","count":11},{"id":"GO:0006584","count":11}]},{"hash":"841058210611042773","title":"Platelet Coagulation and Immune Response","description":"This cluster centers on processes related to coagulation and platelet function (platelet aggregation, blood coagulation), alongside innate immune signaling (complement activation, interleukin-1 response) and immune-related cell interactions (recognition of apoptotic cells). While a few terms pertain to metabolism or stress responses, the dominant theme ties hemostasis to inflammatory signaling, suggesting proteins involved in coagulation-immune axis. Overall, the label Platelet Coagulation and Immune Response captures the core shared function.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070328","count":10},{"id":"GO:0001867","count":9},{"id":"GO:0071347","count":9},{"id":"GO:0072378","count":9},{"id":"GO:0071493","count":9}]},{"hash":"49101929372860239","title":"Biosynthesis and RNA modification enzymes","description":"The cluster\u2019s top GO terms are dominated by biosynthetic processes (antibiotic, biotin, menaquinone biosynthesis) and several RNA-related modification/methylation activities (mRNA cap, tRNA wobble modification, RNA guanine-N7 methylation, arginine methylation). This suggests a cohesive theme around metabolic biosynthesis coupled with RNA modification enzymes, though some terms (nodulation, tellurium response, detoxification) are more peripheral. Overall, a plausible label is a cluster of biosynthesis and RNA-modifying enzymes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":9},{"id":"GO:0009102","count":9},{"id":"GO:0009234","count":6},{"id":"GO:0009877","count":6},{"id":"GO:0006370","count":6}]},{"hash":"1098983608140592014","title":"Neuroimmune development and angiogenesis","description":"This cluster features proteins implicated in neural development (positive regulation of synapse assembly, axonal fasciculation, collagen fibril organization) together with immune responses (innate and adaptive), and vascular processes (angiogenesis and VEGF signaling). The co-occurrence suggests a cohesive theme of neuroimmune interactions during vascularized neural development or remodeling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0001525","count":4}]},{"hash":"1221346666917366830","title":"Embryonic development and organogenesis","description":"GO terms cluster around embryonic development across several organs (forebrain, cardiac neural crest, distal tubule, ciliary body) and developmental signaling (Notch regulation), with a note on immune-related complement activation. This pattern points to a group of proteins involved in developmental morphogenesis and tissue patterning rather than a single tissue.","confidence":"Medium","size":23,"edges":28,"triangles":6,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:1901492","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0045746","count":4},{"id":"GO:0042492","count":3}]},{"hash":"842108009734764408","title":"Mammary gland development and sex differentiation regulators","description":"The cluster centers on developmental processes tied to mammary gland development, sex differentiation, and embryonic genitalia morphogenesis, with links to cell cycle control and transcription regulation, suggesting a cohesive theme of reproductive development. Some terms are broad (DNA-templated transcription), but the strongest signals are mammary and genital development and their regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000045","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0030879","count":2},{"id":"GO:0007548","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2096881718478065262","title":"Plant cell wall glycan biosynthesis and root hair development","description":"The top GO terms cluster around plant-specific glycan and cell-wall related processes, including arabinogalactan protein metabolism, seed coat mucilage biosynthesis, and Lewis A epitope biosynthesis, plus root hair cell development. This points to a shared function in plant cell wall glycosylation and related development, despite a few terms that are less tightly related (e.g., DNA recombination). Overall, a coherent label is plant cell wall glycan biosynthesis with root hair development.","confidence":"Medium","size":23,"edges":10,"triangles":0,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":5},{"id":"GO:0006310","count":4},{"id":"GO:0030311","count":4},{"id":"GO:0001744","count":4},{"id":"GO:0010405","count":4}]},{"hash":"932859159405961707","title":"Ubiquitin-Dependent TNF-NF-\u03baB Innate Immunity","description":"The cluster centers on ubiquitin-driven protein turnover and signaling linked to TNF pathways and NF-\u03baB activation in innate immunity, as shown by high counts for ubiquitin-dependent catabolic process, protein autoubiquitination, TNF-mediated signaling, and I\u03baB phosphorylation. Although there are no reported interactions in the graph, the GO term pattern strongly ties these proteins to ubiquitin-regulated immune signaling rather than metabolic or structural roles.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0045087","count":13},{"id":"GO:1903265","count":13},{"id":"GO:0051865","count":13},{"id":"GO:0033209","count":12}]},{"hash":"1284284033282676271","title":"Neural and Embryonic Development Signaling","description":"This cluster centers on developmental signaling and differentiation in neural and embryonic contexts, as evidenced by terms like neurogenesis, axon guidance, embryonic morphogenesis, and regulation of synapse assembly, along with Hedgehog-related signaling (smoothened) and myoblast differentiation. The collective GO terms suggest shared involvement in coordinating development and neural-muscular differentiation processes, despite disconnected network edges. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0007290","count":2},{"id":"GO:0032147","count":2},{"id":"GO:0048598","count":2}]},{"hash":"1904012860137904001","title":"Axon guidance and neuronal signaling","description":"The top GO terms are dominated by neural-related processes: localization to paranode/juxtaparanode regions of axon, ROBO Roundabout and Smoothened signaling pathways, Rho-mediated signaling, and positive regulation of sodium ion transport. These collectively point to proteins involved in neuron development, axon guidance, and axon region organization. There are a few outliers (e.g., spermatid development, innate immune response, symbiont entry) that may reflect annotation noise or multi-functional proteins, but the prevailing theme is neuronal signaling and axon guidance.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007286","count":6},{"id":"GO:0043552","count":5},{"id":"GO:0071205","count":5},{"id":"GO:0002175","count":5},{"id":"GO:0035023","count":5}]},{"hash":"1648623784968160492","title":"DNA replication, recombination, and cell cycle","description":"The set is enriched for DNA metabolism terms (DNA replication, recombination, DNA integration) and cell cycle/division terms, with telomere maintenance and small GTPase signaling also represented. This points to a cohesive theme of genome replication and cell-cycle control, with some notes on genome integration and host-virus interactions that don\u2019t redefine the primary function. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0032212","count":3}]},{"hash":"2088026300080506615","title":"Pigment and Eye Development with Innate Immunity","description":"The top GO terms cluster around pigment cell differentiation and eye development (melanocyte differentiation, pigmentation regulation, lens fiber cell differentiation) alongside innate immune processes (innate immune response, phagocytosis, macrophage regulation, Fc-epsilon receptor signaling). Although broader developmental terms appear (nervous system, skeletal development), the strongest signals point to pigment/eye lineage development linked with immune signaling, suggesting the cluster represents proteins involved in developmental pathways that intersect pigment biology and innate immunity.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0035855","count":4},{"id":"GO:0048070","count":4},{"id":"GO:0030318","count":4}]},{"hash":"1465954002448948588","title":"Ubiquitin-Proteasome System in Antiviral Immunity","description":"The GO terms are dominated by ubiquitin-dependent proteolysis and polyubiquitination, including SCF-dependent proteasomal pathways, with concurrent signals for innate immune response and defense against viruses. This suggests a cohesive cluster of proteins involved in tagging and degrading substrates as part of antiviral defense, making the label a precise reflection of the group\u2019s primary function.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0000209","count":12},{"id":"GO:0045087","count":10},{"id":"GO:0051607","count":9},{"id":"GO:0042752","count":9}]},{"hash":"86491813388755573","title":"Unknown","description":"The GO terms are largely disparate, spanning labyrinthine layer and lung epithelial development, general phosphorylation signaling, amino acid biosynthesis/metabolism, and responses to antibiotics, cocaine, and lipopolysaccharide. The lack of cohesive functional clustering (no edges/triangles) suggests there isn\u2019t a single shared function linking these proteins, so a confident, unified label isn\u2019t possible.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060711","count":3},{"id":"GO:0010800","count":3},{"id":"GO:0019509","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0009088","count":3}]},{"hash":"1459521015420175522","title":"Immune cell development and signaling","description":"The protein set is enriched for terms related to immune system development and function, including lymphoid differentiation (NK T cell differentiation, B cell affinity maturation, hemopoiesis), cytokine responses (interleukin-7 and interleukin-4 related processes), innate immune response, and NF-kappaB\u2013mediated signaling, suggesting a cluster centered on immune cell development and signaling pathways.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0098761","count":4},{"id":"GO:0001865","count":4},{"id":"GO:0030097","count":4},{"id":"GO:0002344","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1039866972746697909","title":"Developmental transcriptional regulators","description":"The top GO terms cluster around DNA-templated transcription, regulation of transcription factor activity, histone methylation, and development of various tissues (heart, cerebellum, hippocampus, fat cells). This suggests proteins that govern developmental gene expression and epigenetic control across multiple organs. The lack of edges indicates annotations rather than a single protein complex, but the common theme is developmental transcriptional regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0051567","count":3},{"id":"GO:0021695","count":3},{"id":"GO:0033138","count":3}]},{"hash":"569147235903176080","title":"Angiogenesis and immune regulation","description":"The top GO terms point to angiogenesis (GO:0001525) and related ERK/MAPK signaling (GO:0070374 and FGFR-related pathways), suggesting a vascular growth signaling module. Concurrent immunity-related terms (negative regulation of macrophage activation, positive regulation of dendritic cell differentiation, hypersensitivity) and adhesion (homophilic/heterophilic cell-cell adhesion) indicate integration of endothelial/vascular signaling with immune cell interactions. Taken together, these terms describe a cluster of proteins central to angiogenic signaling that also modulates immune cell behavior and cell adhesion.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0043031","count":4},{"id":"GO:0007157","count":4},{"id":"GO:1902178","count":4}]},{"hash":"2057494197495479666","title":"Deubiquitination and ubiquitin-mediated degradation","description":"Based on the GO terms, the proteins are linked to removing ubiquitin from substrates across several linkages (K6, K29, K11, K48) and to a ubiquitin-dependent protein catabolic process via the multivesicular body pathway, indicating a shared role in ubiquitin turnover and protein degradation. While a few other terms appear, the dominant signal is deubiquitination and ubiquitin-regulated degradation. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044313","count":2},{"id":"GO:0035523","count":2},{"id":"GO:0035871","count":2},{"id":"GO:0071108","count":2},{"id":"GO:0019509","count":2}]},{"hash":"1587706950573774824","title":"Transcription Regulation and Chromatin Remodeling","description":"Although the set includes a diverse mix of terms, the strongest signals point to regulation of gene expression via transcription and chromatin remodeling (DNA-templated transcription, negative regulation of transcription initiation, chromatin remodeling). Related terms (developmental processes and multicellular organism development) reinforce a theme of transcriptional control during development. A couple of terms on intracellular transport and GTPase regulation are ancillary and could reflect broader cellular signaling, but the core theme remains transcriptional regulation and chromatin dynamics during development and differentiation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0080182","count":1},{"id":"GO:0006351","count":1},{"id":"GO:2000143","count":1}]},{"hash":"1313585751369627103","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":59,"triangles":51,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0000447","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0000480","count":3}]},{"hash":"414769403291703382","title":"Viral replication and host cell entry and release","description":"The GO terms show a clear theme around steps of the viral life cycle (virion assembly, proviral latency, viral release) and host processes that viruses commonly exploit (mRNA splicing regulation, ncRNA-mediated silencing, transcription regulation, protein folding). This suggests the cluster comprises proteins tied to viral replication and the corresponding host interactions.","confidence":"High","size":22,"edges":137,"triangles":553,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":8},{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0019068","count":6},{"id":"GO:0030260","count":6}]},{"hash":"783208469105646902","title":"Eye development and morphogenesis","description":"Most of the top GO terms are about eye morphogenesis and retina development (camera-type eye, embryonic eye morphogenesis, retina development in camera-type eye), with additional terms on branching morphogenesis in other organs. This points to a core theme of developmental morphogenesis with a particular emphasis on eye development.","confidence":"High","size":22,"edges":229,"triangles":1500,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":10},{"id":"GO:0006366","count":10},{"id":"GO:0002087","count":9},{"id":"GO:0002076","count":9},{"id":"GO:0060441","count":8}]},{"hash":"1821234042909921089","title":"Translation and secretory pathway components","description":"GO terms cluster around translation (protein synthesis), protein processing, and vesicle-mediated transport between the ER and Golgi, including SNARE complex disassembly and ER polarization. These features point to the secretory pathway and intracellular protein maturation as the core theme, with ATP-dependent steps reflected by energy metabolism terms. A single outlier term (cobalamin biosynthetic process) likely represents noise, but the dominant signal supports a ribosome-associated synthesis with secretory trafficking theme.","confidence":"Medium","size":22,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0009236","count":2},{"id":"GO:0048219","count":2},{"id":"GO:0061166","count":2}]},{"hash":"1471524985822576926","title":"Pyroptosis and innate immune signaling","description":"The dominant GO terms indicate inflammatory programmed cell death (apoptosis and pyroptosis) and innate immune responses, coupled with protein ubiquitination, suggesting the cluster centers on inflammatory cell death and immune signaling. Although some terms touch on mitosis or cardiac action potential, the core signal is pyroptosis/apoptosis with innate immunity (CD40 signaling, T cell cytotoxic susceptibility, Ig production). This supports a cohesive theme of inflammatory cell death linked to immune activation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006915","count":16},{"id":"GO:0070269","count":16},{"id":"GO:0016567","count":16},{"id":"GO:1990001","count":16},{"id":"GO:0045087","count":16}]},{"hash":"572830649722223771","title":"Developmental signaling and morphogenesis","description":"This cluster is enriched in terms related to development (skin development, multicellular organism development, fertilization) and signaling regulation (GTPase activity, serine/threonine kinase activity, protein autophosphorylation), suggesting a developmental program coordinated by signaling and cytoskeletal dynamics, with additional stress-response and trafficking context that may support developmental processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034316","count":8},{"id":"GO:0007338","count":8},{"id":"GO:0043588","count":8},{"id":"GO:0043547","count":7},{"id":"GO:0031954","count":7}]},{"hash":"1721811598431731982","title":"Proviral integration and DNA replication","description":"Top GO terms strongly point to viral DNA integration and proviral latency, along with RNA-templated DNA biosynthesis, DNA replication, and recombination. This suggests a cluster centered on reverse transcription and integration of viral DNA into the host genome, with supportive DNA synthesis and repair processes; some terms also reflect host-symbiont interactions, but the core theme remains proviral integration and DNA synthesis.","confidence":"Medium","size":22,"edges":39,"triangles":9,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0006278","count":3},{"id":"GO:0046718","count":3}]},{"hash":"1355613167477526430","title":"Ribosome Biogenesis and rRNA Processing","description":"The strongest signals are rRNA maturation (LSU and 5.8S) and RNA guanine-N7 methylation, which are central to ribosome biogenesis and rRNA processing. While other terms touch on transcription and cell cycle, the predominant pattern points to ribosome assembly and RNA processing roles, with some multifunctionality or annotation noise explaining the additional GO terms.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0002091","count":2}]},{"hash":"2199914765163296770","title":"Stimulus-Responsive Signaling and Trafficking","description":"This cluster combines GO terms tied to responses to various stimuli (interferons, biotic stimuli, insulin) with intracellular trafficking and neuronal/developmental processes (endosome transport, synaptic vesicle clustering, neuromuscular control, bone morphogenesis). The common thread is signaling and the cellular handling of external cues through transport and regulatory mechanisms, rather than a single dedicated pathway. ","confidence":"Medium","size":22,"edges":227,"triangles":1466,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0046597","count":5},{"id":"GO:0010610","count":4},{"id":"GO:0044381","count":4},{"id":"GO:0035455","count":4},{"id":"GO:0050884","count":4}]},{"hash":"1513785569439307779","title":"Unknown","description":"The terms span mechanotransduction, leukotriene synthesis, immune activation, organ growth, auditory sensation, cytoskeletal assembly, and mitochondrial regulation, with no single cohesive function or pathway evident and no edges linking proteins, so a confident, concise label cannot be assigned.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0019370","count":4},{"id":"GO:0006968","count":4},{"id":"GO:0050798","count":4},{"id":"GO:0035265","count":4}]},{"hash":"1720763600453501508","title":"Neural development and synapse formation","description":"Rationale: The dominant terms are nervous system development and positive regulation of synapse assembly, indicating a cluster enriched for neural development and synaptic connectivity. Additional terms point to broader developmental signaling, including lung mesenchyme development and growth factor\u2013related pathways, which fits a general developmental context rather than a single tissue-specific function. Some OBsolete terms are present, but the core theme remains neural development and synapse formation.","confidence":"Medium","size":22,"edges":173,"triangles":726,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010863","count":8},{"id":"GO:0070640","count":8},{"id":"GO:2000830","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0051965","count":8}]},{"hash":"2056716158251317857","title":"Plant fatty acid biosynthesis and seed germination","description":"The cluster is dominated by GO terms for fatty acid biosynthesis and metabolism across multiple chain lengths (long-, very long-, medium-chain fatty acids, and acyl-CoA metabolism), plus the positive regulation of seed germination, pointing to a plant lipid biosynthesis\u2013germination linkage. While some secondary metabolism terms appear (phenylpropanoid, phenylacetate), the central theme is lipid production and utilization in seeds.","confidence":"Medium","size":22,"edges":130,"triangles":321,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":11},{"id":"GO:0044539","count":9},{"id":"GO:0000038","count":9},{"id":"GO:0010030","count":9},{"id":"GO:0036112","count":9}]},{"hash":"1168728425458682548","title":"Neural development and synaptic organization","description":"The cluster is dominated by neural-related GO terms: nervous system development, synapse organization, neuromuscular process controlling posture, sensory perception of sound, vocalization behavior, and synaptic vesicle clustering, suggesting roles in neural development and synaptic signaling. A few terms related to metabolic or immune responses appear but do not override the central neural theme. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007157","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0050808","count":2}]},{"hash":"159449957386804980","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071037","count":3},{"id":"GO:0036450","count":3},{"id":"GO:0071051","count":3},{"id":"GO:0071035","count":3},{"id":"GO:0071040","count":3}]},{"hash":"1373504968939656719","title":"Retina development and visual signaling","description":"This cluster centers on eye/retinal processes and vision-related signaling, with terms like retina vasculature development in camera-type eye, visual perception, and regulation of VEGF signaling. Additional terms such as positive regulation of Notch signaling, receptor internalization, and paranodal junction assembly suggest neural/photoreceptor development and signal transduction aspects linked to the visual system. A few terms (oxidant detoxification, immune-related regulation) are less specific but can relate to retinal stress responses and signaling contexts. Overall, the theme points to retina development and visual function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":4},{"id":"GO:0030913","count":4},{"id":"GO:0045747","count":4},{"id":"GO:0031623","count":4},{"id":"GO:0055114","count":3}]},{"hash":"236439401833364060","title":"Immune Response and Organogenesis","description":"The proteins show a noticeable signal for inflammatory/innate immune responses, but also multiple development-related processes across various tissues (nipple morphogenesis, kidney glomerulus development, ovarian follicle growth, lung connective tissue development). The mix suggests no single dominant function, hence a label that reflects both immune activity and developmental processes rather than a single specialized function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0060658","count":3},{"id":"GO:0032962","count":3},{"id":"GO:0072224","count":3}]},{"hash":"1975822237214894389","title":"Gene expression and genome maintenance with mitochondria","description":"This cluster centers on core gene expression processes (translation, transcription, rRNA modification) and genome maintenance (DNA repair) with mitochondrial function and apoptosis involvement, suggesting a theme of basic cellular machinery and mitochondrial activity with stress responses. Some terms (antibiotic response, placenta development) are likely incidental.","confidence":"Medium","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0070475","count":2}]},{"hash":"638017422696704646","title":"Neural development and synaptic organization","description":"The top GO terms cluster around neuronal development and synaptic organization: neuron cell-cell adhesion, postsynaptic membrane assembly, cytoskeletal matrix organization at the active zone, and regulation of glutamatergic transmission, plus acetylcholine catabolic processes in the synaptic cleft and vesicle clustering. While terms like retina or osteoblast development appear, the strongest signal is toward synapse formation, maintenance, and neurotransmission, suggesting proteins tied to neural development and synaptic function. ","confidence":"High","size":22,"edges":217,"triangles":1288,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0002076","count":13},{"id":"GO:0002087","count":13},{"id":"GO:0060041","count":13},{"id":"GO:0051968","count":11},{"id":"GO:0007158","count":11}]},{"hash":"498784972256976607","title":"Coagulation, Platelet Activation, and Fibrinolysis","description":"The top GO terms center on platelet activation, coagulation, fibrinolysis (plasminogen activation, fibrin clot formation), and complement pathways, indicating a hemostasis-focused cluster. In addition, there are signals of vascular remodeling (angiogenesis) and inflammatory responses (IL-1), which often accompany coagulation in vascular injury contexts, making this naming both accurate and specific to the dominant function. Some lipid-related terms are present but appear peripheral to the core hemostatic theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030168","count":9},{"id":"GO:0001867","count":9},{"id":"GO:0044320","count":9},{"id":"GO:0031639","count":9},{"id":"GO:0045766","count":9}]},{"hash":"788241021451301143","title":"Lipid Metabolism and Energy Starvation Response","description":"The cluster is enriched for fatty acid oxidation and related lipid metabolism processes (beta-oxidation, acyl-CoA dehydrogenase, carnitine metabolism, steroid biosynthesis) and energy-stress signals (response to starvation), suggesting a cohesive theme of lipid catabolism and energy homeostasis, with liver and cardiac development terms supporting tissue contexts; a translation term may reflect background cellular activity but does not define the core theme.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0042594","count":3},{"id":"GO:0006694","count":3},{"id":"GO:0051793","count":3}]},{"hash":"1443929582876418994","title":"Steroid, retinoid, and pigment biosynthesis","description":"The top GO terms center on biosynthetic and metabolic processes for steroids (testosterone, estrogen, glucocorticoids), retinoids (retinol, retinal), and pigment production (melanin), indicating a cohesive theme of biosynthesis/metabolism of these molecules. While there are outliers like antibiotic biosynthetic process and lung development, these do not outweigh the shared emphasis on steroid/retinoid/pigment biosynthesis.","confidence":"High","size":22,"edges":9,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0042574","count":8},{"id":"GO:0061370","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0042438","count":8}]},{"hash":"1323557401670824753","title":"Ubiquitination-regulated innate apoptosis and pyroptosis","description":"This cluster is dominated by terms for programmed cell death (apoptosis, pyroptosis) and innate immune signaling, with ubiquitination as a key regulatory mechanism. A few terms such as mitotic spindle assembly appear less central, but overall the theme is cell death and inflammatory regulation.","confidence":"High","size":22,"edges":164,"triangles":567,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":21},{"id":"GO:0070269","count":21},{"id":"GO:0016567","count":21},{"id":"GO:1990001","count":21},{"id":"GO:0045087","count":21}]},{"hash":"474362203430635576","title":"Apoptosis and Pyroptosis in Innate Immunity","description":"This cluster is dominated by GO terms for apoptotic process, pyroptotic inflammatory response, and innate immune response, with substantial enrichment for ubiquitination, indicating a core role in programmed cell death and innate immune signaling. A few development-related terms appear at low frequency, likely not representative of the main function. High","confidence":"","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":16},{"id":"GO:0006915","count":15},{"id":"GO:0070269","count":15},{"id":"GO:0016567","count":15},{"id":"GO:1990001","count":15}]},{"hash":"1380380636408510038","title":"Coagulation and vascular development","description":"This cluster's top GO terms cluster around blood coagulation and vascular processes\u2014complement activation, plasminogen activation, platelet activation, vasoconstriction regulation, and lymph vessel morphogenesis\u2014suggesting a shared function in coagulation/hemostasis and vascular remodeling. A subset of terms relates to metanephric development and duct development, indicating potential links to kidney vasculature development. Overall, the label captures the dominant themes with some developmental context.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0045907","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0051968","count":5}]},{"hash":"1711290622038225438","title":"Developmental transcription and angiogenic signaling","description":"These proteins show enrichment for transcriptional regulation (DNA-templated transcription, regulation of transcription) together with signaling and developmental processes (ERK1/2 cascade regulation, mesoderm formation, angiogenesis). This suggests a cohesive role in coordinating gene expression with MAPK signaling to drive mesodermal development and vascular formation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0001707","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0006397","count":2}]},{"hash":"1572552841911075646","title":"NF-kB-driven inflammatory and antiviral signaling","description":"The GO terms cluster around canonical NF-kB activation, inflammatory responses (IL-6 production, inflammatory regulation), responses to LPS and pathogen defense (virus), plus JNK signaling and TH1-type immune responses, indicating a cohesive immune signaling module centered on NF-kB\u2013mediated inflammation and antiviral defense.","confidence":"High","size":22,"edges":15,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0071222","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0050729","count":3}]},{"hash":"1551636266375133366","title":"Axon guidance and neural signaling","description":"Top GO terms cluster around neural development and signaling\u2014Roundabout signaling (axon guidance), Rap-mediated signaling, nervous system development, and neuromuscular balance\u2014indicating proteins involved in neural patterning and signaling cascades. Additional terms on endocytosis, phospholipid homeostasis, ER stress\u2013related apoptosis, and development of other tissues (kidney, T cell signaling) point to shared signaling machinery and cellular trafficking, but the dominant theme remains neural development and axon guidance.","confidence":"Medium","size":22,"edges":41,"triangles":14,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":13},{"id":"GO:0010628","count":13},{"id":"GO:0032486","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0001822","count":13}]},{"hash":"1457234197697322126","title":"mRNA Splicing and Translation Regulation","description":"The cluster is dominated by GO terms tied to RNA processing and control of translation, including mRNA splice site recognition, regulation of alternative mRNA splicing via the spliceosome, mRNA export, formation of the translation preinitiation complex, and regulation of translational initiation, as well as mRNA modification and stress-related mRNA stability. This suggests a coherent role in post-transcriptional processing and regulation of translation rather than a single, narrow function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":3},{"id":"GO:0000381","count":3},{"id":"GO:0002188","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0016556","count":2}]},{"hash":"1061623688122595317","title":"Immune signaling and lymphatic development","description":"The top terms are strongly centered on immune responses (cellular response to fungal origin, leukocyte tethering/rolling, Fc-gamma receptor signaling, complement activation) with a notable subset related to tissue remodeling and lymphatic development (lymph vessel morphogenesis, cartilage condensation, metanephric development). This suggests a cluster representing immune activation intertwined with vascular/lymphatic and developmental processes.","confidence":"Medium","size":22,"edges":187,"triangles":845,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":22},{"id":"GO:0001502","count":20},{"id":"GO:0072218","count":18},{"id":"GO:2000502","count":18},{"id":"GO:0001867","count":18}]},{"hash":"678767329744104983","title":"Steroid and xenobiotic metabolism","description":"The top GO terms largely reflect processing and breakdown of steroid-related molecules (estrogen catabolic process, bile acid catabolic process, catecholamine metabolism) and detoxification of xenobiotics, with supporting sulfur-containing and glycosaminoglycan-related pathways (sulfate assimilation, heparan/dermatan sulfate biosynthesis). This suggests a cohesive role in chemical modification and clearance of hormones and foreign compounds. ","confidence":"High","size":22,"edges":120,"triangles":319,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":12},{"id":"GO:0006711","count":11},{"id":"GO:0002002","count":11},{"id":"GO:0006584","count":11},{"id":"GO:0030205","count":11}]},{"hash":"1038455504519956325","title":"Neural development and synaptic plasticity","description":"Most GO terms point to nervous system development and synaptic function (axonogenesis, Schwann cell development, visual perception, long-term potentiation/depression, excitatory postsynaptic potential, multicellular organism development). The heart contraction term is less representative, so the cluster is best characterized as a neuronal development and synaptic signaling module.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098735","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0060292","count":3}]},{"hash":"534567870291865454","title":"Ubiquitin-dependent regulation of apoptosis and immune signaling","description":"This cluster emphasizes ubiquitination and endocytosis as core processes, with concurrent roles in apoptosis and immune modulation (negative regulation of IL-1\u03b2 and IL-8, NK cell cytotoxicity), plus links to viral release and cell migration, suggesting a cohesive theme of ubiquitin-mediated control of cell fate and immune responses.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0070086","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0032691","count":2},{"id":"GO:0032717","count":2}]},{"hash":"164901874064223949","title":"Blood coagulation and fibrinolysis with vascular remodeling","description":"This cluster centers on coagulation and fibrinolysis (complement activation via lectin pathway; plasminogen activation; fibrinolysis; clot formation; platelet regulation) and includes angiogenesis and cell-matrix adhesion, suggesting a theme of hemostasis coupled with extracellular matrix remodeling and tissue repair/inflammation (IL-1 response). Some terms like UV-B response and NMJ axon regeneration reflect broader injury/repair signals but can accompany coagulation-driven remodeling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0031639","count":7},{"id":"GO:0045766","count":7},{"id":"GO:0042730","count":7},{"id":"GO:0071347","count":7}]},{"hash":"2144763621585865657","title":"GPCR Signaling and Metabolic Regulation","description":"This cluster centers on signal transduction and energy/homeostasis processes, as indicated by enrichment for adenylate cyclase-activating GPCR pathways, Rho signaling, insulin secretion regulation, and diet-induced thermogenesis, along with the electron transport chain. While some terms (nipple morphogenesis, lung connective tissue development, temperature response, and fear behavior) seem more development- or context-specific, the core theme ties to GPCR/Rho-mediated signaling and metabolic control influencing vascular physiology and energy balance.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":10},{"id":"GO:0035025","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0060658","count":7}]},{"hash":"1637073582264080879","title":"Ubiquitin-Proteasome Mediated Proteolysis","description":"This cluster is dominated by ubiquitin-dependent protein degradation terms (ubiquitin-dependent proteolysis, protein polyubiquitination, SCF-dependent proteasomal degradation), indicating a core function in protein turnover via the ubiquitin-proteasome system. Additional terms related to circadian rhythm, DNA damage checkpoints, and stress responses (cadmium, oxidative stress) suggest regulation of degradation linked to cell-cycle control and neuronal signaling. Overall, the cohesive theme is proteostasis through ubiquitination and proteasomal degradation, with linked regulatory cues.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0000209","count":13},{"id":"GO:0042752","count":11},{"id":"GO:0031146","count":9},{"id":"GO:0031571","count":8}]},{"hash":"1242459565662696245","title":"Embryonic development and placental formation","description":"The top GO terms are dominated by embryogenesis- and morphogenesis-related processes (trophoblast giant cell differentiation, placental development, left/right pattern formation, cartilage morphogenesis, EMT in heart development), which together point to embryonic development and placental lineage differentiation. Ubiquitin-dependent protein catabolic process and innate immune response likely reflect regulatory and protective mechanisms active during development. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0060707","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0035270","count":5}]},{"hash":"569229043072199229","title":"Cardiac mechanotransduction and electrical signaling","description":"The terms show strong enrichment for mechanical stimulus response and heart-specific electrical activity, including cellular response to mechanical stimulus, response to muscle stretch, regulation of SA node cell action potential, and SA node cell communication with atrial cardiac muscle cells. These point to cardiac mechanosensing and electrical coupling as the core theme. While other terms touch on metabolism and immune regulation, they are less central to this cluster\u2019s main signal.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070328","count":4},{"id":"GO:0072660","count":4},{"id":"GO:0035994","count":4},{"id":"GO:0045083","count":4},{"id":"GO:0071260","count":4}]},{"hash":"255916198465713518","title":"Nervous system development and axon guidance","description":"This cluster is dominated by GO terms related to neural development and connectivity, including neural tube closure, cerebellum development, nervous system development, and fasciculation of sensory neuron axons, suggesting a theme centered on neural development and axon guidance. Some immune-related terms appear but seem secondary to the main nervous-system-focused signals. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:2001028","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0021549","count":3}]},{"hash":"1577947932021325271","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms point to multiple facets of development and morphogenesis\u2014placental and endocrine system development, left/right patterning, cartilage morphogenesis, and EMT\u2014indicating a cohesive embryonic development/tissue formation theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060536","count":5}]},{"hash":"1561608402629583956","title":"Neural development and Hedgehog signaling","description":"The top GO terms are dominated by nervous system development (including peripheral nervous system) and myelination, with smoothened signaling pathway (Hedgehog) implicating Hedgehog pathway activity. While a few terms touch on heart development or immune regulation, the prevailing pattern centers on neural development and myelin processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":8},{"id":"GO:0010863","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0007224","count":6},{"id":"GO:0045663","count":6}]},{"hash":"449890135377343624","title":"Neuronal actin dynamics and endocytosis","description":"This cluster centers on neuronal cytoskeleton dynamics and vesicle trafficking: Arp2/3-mediated actin nucleation, Rho signaling, dendrite extension, synaptic vesicle endocytosis, endocytic recycling, and calcium-channel regulation. A few terms (e.g., bud site selection, cholesterol storage) are less directly aligned but do not override the main neuronal remodeling theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000601","count":4},{"id":"GO:0050731","count":4},{"id":"GO:0035023","count":4},{"id":"GO:1901387","count":4},{"id":"GO:2001137","count":3}]},{"hash":"462399075483300184","title":"Tissue morphogenesis","description":"GO terms center on developmental shaping of tissues and organs across multiple contexts (myelination, axonogenesis, lymph vessel morphogenesis, nephron tubule morphogenesis, nipple morphogenesis, and collagen fibril organization). This points to a common theme of morphogenesis and extracellular matrix remodeling during development, rather than a single specific function. Therefore, Tissue morphogenesis is a representative label.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042552","count":4},{"id":"GO:0036303","count":4},{"id":"GO:0072287","count":4},{"id":"GO:0072237","count":4},{"id":"GO:0030199","count":4}]},{"hash":"1904416765951565095","title":"GABAergic and cholinergic brain signaling","description":"These proteins are strongly linked to neural communication: GABA signaling and GABA receptor clustering, plus acetylcholine receptor signaling, dopamine secretion, and innervation. The presence of locomotory behavior, conditioned taste aversion, and brain-region development (LGN) points to brain-wide synaptic activity and its modulation of behavior and autonomic functions, supporting a cohesive theme of inhibitory/excitatory neurotransmission in the brain.","confidence":"High","size":21,"edges":84,"triangles":94,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007214","count":20},{"id":"GO:0007626","count":20},{"id":"GO:0001661","count":20},{"id":"GO:0021771","count":19},{"id":"GO:0097112","count":19}]},{"hash":"368416547486822811","title":"DNA Replication and Repair, SOS Response","description":"The proteins in this cluster are enriched for processes tied to DNA replication (e.g., DNA replication, primer synthesis), DNA damage response and repair pathways (nucleotide-excision repair, double-strand break repair, SOS response), and related genome maintenance activities, indicating a cohesive role in replication integrity and damage response.","confidence":"High","size":21,"edges":200,"triangles":1165,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009432","count":20},{"id":"GO:0006265","count":20},{"id":"GO:0006268","count":20},{"id":"GO:0006306","count":20},{"id":"GO:0006269","count":20}]},{"hash":"1260544577427680733","title":"Chromatin Organization and Nucleosome Assembly","description":"The top terms cluster around chromatin-related processes: heterochromatin organization, nucleosome assembly, and histone modification marks (even though some terms are obsolete). A few outliers (cell-matrix adhesion, development) are minor, but the dominant signal is chromatin structure and nucleosome dynamics, suggesting the proteins function together in chromatin organization and nucleosome regulation.","confidence":"High","size":21,"edges":14,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":5},{"id":"GO:0070828","count":5},{"id":"GO:0006334","count":5},{"id":"GO:0097298","count":5},{"id":"GO:0016584","count":5}]},{"hash":"1153298116819700477","title":"Transcriptional Regulators and Mammalian Development","description":"The cluster centers on transcriptional regulation (negative/positive regulation of RNA polymerase II, DNA-templated transcription) with accompanying tissue-development terms (Leydig cell differentiation, mammary gland alveolus development). This suggests proteins that modulate transcription while participating in hormone- or tissue-specific development programs in mammals. Some terms like early viral transcription and insulin signaling reflect regulatory cross-talk, but the dominant theme is transcription control linked to development.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0033327","count":7},{"id":"GO:0060749","count":7},{"id":"GO:0019085","count":6}]},{"hash":"1405749726139933789","title":"Proteoglycan Biosynthesis and Metabolism","description":"This cluster is dominated by GO terms for proteoglycan biosynthesis and proteoglycan metabolic processes involving glycosaminoglycan chains (heparan, dermatan, chondroitin sulfate), indicating a cohesive role in proteoglycan assembly and turnover and associated extracellular matrix development (e.g., chondrocyte development, ureteric bud formation).","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":4},{"id":"GO:0030206","count":4},{"id":"GO:0015768","count":3},{"id":"GO:0002063","count":3},{"id":"GO:0060676","count":3}]},{"hash":"5030421504564761","title":"GPCR signaling and immune cell trafficking","description":"The top terms cluster around GPCR internalization, receptor clustering, and chemotaxis/regulation of immune cells (dendritic cells, monocytes, macrophages), indicating signaling pathways that guide immune cell movement and receptor dynamics. Some cardiovascular and reproductive terms appear but are likely peripheral annotations; the dominant theme is GPCR-related signaling linked to immune cell migration.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0002407","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0090026","count":2},{"id":"GO:0007507","count":2}]},{"hash":"2089463850434300249","title":"Immune Signaling and Development","description":"This cluster shows a clear tilt toward immune-related processes, with multiple terms for innate and adaptive immune signaling (innate immune response, defense against bacterium, T cell receptor signaling, regulation of interferon production). At the same time, there are several development-associated terms (heart development, megakaryocyte development, dendritic spine development) and other signaling-related processes (ion transport, slit diaphragm assembly), suggesting the proteins participate in immune signaling with ancillary developmental roles. Confidence: Medium","confidence":"","size":21,"edges":33,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048671","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0061000","count":4},{"id":"GO:0035855","count":4},{"id":"GO:0071805","count":4}]},{"hash":"2249537523164817532","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning endothelial proliferation, spermatogenesis, meiosis pairing, mRNA processing, immune signaling, neuronal receptor clustering, and DNA damage response, with no single unifying function clearly tying the cluster together. Thus no specific, coherent theme is evident beyond broad cellular processes. ","confidence":"","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0007129","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0045087","count":2}]},{"hash":"259399120709377183","title":"Immune Activation Signaling","description":"This cluster is dominated by terms related to immune function, including innate immune response, B cell receptor signaling, B cell affinity maturation, and activated T cell proliferation, suggesting a cohesive theme of immune activation across innate and adaptive immunity; a few outlier terms like heart development and synapse assembly likely reflect pleiotropy or annotation noise, but the primary signal is immune signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0050853","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0051092","count":8},{"id":"GO:0051965","count":7}]},{"hash":"1964367989377613891","title":"Coagulation, Fibrinolysis, and Complement Activation","description":"The top GO terms cluster around blood coagulation, fibrinolysis, and complement activation (lectin pathway), with plasminogen activation and fibrin clot formation as central processes. Additional signals for angiogenesis and immune responses (IL-1 signaling) and neural repair at NMJ suggest a theme of extracellular proteolysis and tissue remodeling during healing and immune activity. This combination justifies a label focusing on coagulation and immune-modulatory proteolysis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":14},{"id":"GO:0031639","count":13},{"id":"GO:0045766","count":13},{"id":"GO:0042730","count":13},{"id":"GO:0007171","count":12}]},{"hash":"1408175489916882077","title":"Platelet Activation and Coagulation","description":"This cluster centers on hemostasis and platelet function, with terms for platelet activation/aggregation, fibrin clot formation, and regulation of platelet activity. It also includes immune-related terms (complement activation, IL-1 response) and clearance signals (recognition of apoptotic cells), suggesting a link between coagulation and immune surveillance. A few outliers (UV-B response, embryonic heart patterning) may reflect broader signaling contexts but do not override the main theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030168","count":7},{"id":"GO:0060971","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0071347","count":6},{"id":"GO:0072378","count":6}]},{"hash":"1657043770953683802","title":"Vertebrate Organ Development Across Tissues","description":"The top GO terms indicate broad developmental roles across multiple vertebrate organs and systems (nervous system, retina, pituitary, muscle, habenula, gonads) along with a general transcriptional regulatory process, suggesting these proteins contribute to general embryonic and organogenesis programs rather than a single pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0090009","count":7},{"id":"GO:0048935","count":7},{"id":"GO:0060041","count":6},{"id":"GO:0007275","count":6}]},{"hash":"1132849885215774797","title":"Developmental signaling and organogenesis","description":"This cluster is enriched for GTPase-mediated signaling, actin cytoskeleton organization, and IGF receptor signaling, together with development-related terms such as forebrain development, spleen development, organ induction, and multicellular organism development. The combination points to signaling pathways driving morphogenesis and organ formation, with additional links to immune/vascular regulation during development.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0048009","count":3},{"id":"GO:0043314","count":3},{"id":"GO:0060313","count":3}]},{"hash":"564833132241030603","title":"Coagulation, fibrinolysis, and angiogenesis","description":"The top terms point to blood coagulation and fibrinolysis, with plasminogen activation and fibrin clot formation, plus a strong signal for angiogenesis and immune/coagulation cross-talk (complement activation, platelet regulation). This suggests a cohesive cluster of proteins involved in vascular hemostasis and remodeling, with related signaling pathways. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0007171","count":11},{"id":"GO:0031639","count":11},{"id":"GO:0045766","count":11},{"id":"GO:0042730","count":11}]},{"hash":"607781621383902420","title":"Cell signaling and cell cycle regulation","description":"The terms cluster around regulation and signaling across pathways (NF-kappaB signaling, ubiquitination, kinase activity) plus mitotic processes (mitotic cell cycle, cytokinesis) and translation, indicating a broad regulatory module rather than a single pathway.","confidence":"Medium","size":21,"edges":193,"triangles":1045,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:1902527","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0032465","count":2}]},{"hash":"315975751016990824","title":"MAPK-immune signaling regulators","description":"This cluster is enriched for GO terms that negatively regulate the ERK/MAPK cascade and T cell receptor signaling, and includes terms related to cytokine production (IL-6, interferon), unfolded protein response, and endothelial barrier maintenance. The common thread is regulation (often dampening) of immune and MAPK signaling, rather than direct effector responses, suggesting these proteins act as regulators of MAPK and immune pathways.","confidence":"High","size":21,"edges":209,"triangles":1311,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":20},{"id":"GO:0050860","count":20},{"id":"GO:0000200","count":20},{"id":"GO:0030948","count":17},{"id":"GO:0034165","count":16}]},{"hash":"777704607698935605","title":"Neuronal development and membrane trafficking","description":"This cluster combines GO terms pointing to neuronal development (dendritic spine formation, interneuron migration, learning) with cellular trafficking processes (Golgi-to-plasma membrane transport, Golgi localization, endosome/lysosome transport, phagophore localization) and Hedgehog signaling (Smoothened pathway). The shared theme appears to be proteins involved in neural development that also function in intracellular transport, giving a coherent, but not perfect, link. ","confidence":"Medium","size":21,"edges":9,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045197","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0043001","count":6},{"id":"GO:0060999","count":6},{"id":"GO:0007612","count":6}]},{"hash":"1185954814180640083","title":"Unknown","description":"The Top Terms are highly heterogeneous, ranging from immune cytokine production and LPS response to pollen recognition and even plant- or non-immune-related stress terms. There isn\u2019t a single coherent biological theme uniting all terms, so a concise, representative label isn\u2019t evident. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":20},{"id":"GO:0045401","count":20},{"id":"GO:0045425","count":20},{"id":"GO:0071222","count":20},{"id":"GO:2000811","count":20}]},{"hash":"2236838291212395311","title":"Neuro-immune GPCR signaling and thermoregulation","description":"The cluster is enriched for nervous-system related terms (temperature stimulus response, diet-induced thermogenesis, pain perception, enteric nervous system development) alongside immune/inflammatory terms (immune response, eosinophil degranulation, bone remodeling) and signaling pathways (adenylate cyclase-activating GPCR signaling, Rho signaling) with regulators like blood pressure. Together, these imply neural-immune communication mediated by GPCR/Rho signaling that ties into metabolic and thermoregulatory processes.","confidence":"Medium","size":21,"edges":18,"triangles":6,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0048484","count":5},{"id":"GO:0043311","count":5}]},{"hash":"1490767745340344346","title":"Actin Cytoskeleton Remodeling and Exocytosis","description":"The cluster shows enrichment for cytoskeleton-related terms (actin filament network formation, sarcomere organization) alongside vesicle trafficking (exocytosis) and regulatory signals (Rho pathway), indicating a cohesive module coordinating actin dynamics with secretion/trafficking processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051639","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0006887","count":2},{"id":"GO:0035023","count":2},{"id":"GO:2000009","count":2}]},{"hash":"1286920799193687887","title":"TNF-driven immune and apoptotic signaling","description":"The top GO terms cluster around immune activation (T cell receptor/MHC interactions), extrinsic and execution-phase apoptosis, and TNF-mediated pathways, with supporting signals for cytoskeletal remodeling (filopodium assembly) and vascular/hemostatic processes (platelet aggregation, vasoconstriction) as well as glucocorticoid response. This combination suggests a cohesive theme of inflammatory/immune signaling closely tied to apoptosis, dominated by TNF-related processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097192","count":2},{"id":"GO:0002291","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0070527","count":2},{"id":"GO:0033209","count":2}]},{"hash":"147623285975411964","title":"DNA Repair and Oxidative Stress Response","description":"This cluster is enriched for DNA repair processes (base-excision repair) and DNA recombination, along with cellular responses to hydrogen peroxide and xenobiotics, suggesting a theme of genome maintenance under oxidative/chemical stress; other terms point to stress-related post-transcriptional regulation, supporting this focus.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":3},{"id":"GO:0046856","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0070301","count":2},{"id":"GO:0042493","count":2}]},{"hash":"2305034731200569303","title":"Methionine and choline one-carbon metabolism","description":"Most terms cluster around methyl-group transfer and methionine/choline catabolism: S-methylmethionine cycle, L-methionine salvage, choline and betaine catabolic processes, and homocysteine regulation. These points suggest a unifying theme in one-carbon metabolism for the cluster. Some terms (receptor internalization, calcium/potassium transport, light perception) are less central and may reflect peripheral membrane-related functions rather than core methyl-donor metabolism. Given the strongest signal is methyl-donor pathways, this label captures the primary theme, with ancillary processes as possible secondary associations.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":4},{"id":"GO:0033528","count":3},{"id":"GO:0071267","count":3},{"id":"GO:0006579","count":3},{"id":"GO:0042558","count":3}]},{"hash":"290440175209379346","title":"Neurodevelopment and inflammatory signaling","description":"The cluster is dominated by neural development terms (axon guidance through the spinal cord, axon extension, and synapse assembly, including corticospinal neuron guidance) suggesting a core neural development theme. The presence of inflammatory response and negative regulation of angiogenesis indicates concurrent immune and vascular remodeling signals, which often accompany neural development and tissue patterning. Together, these terms point to a cohesive theme of neural development with inflammatory/vascular regulatory cues.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016525","count":10},{"id":"GO:0006954","count":9},{"id":"GO:0071372","count":8},{"id":"GO:0019800","count":8},{"id":"GO:0051965","count":8}]},{"hash":"1082244989655703796","title":"CNS neural signaling and membrane trafficking","description":"The terms cluster around membrane localization and SNARE-mediated trafficking, synaptic receptor localization, and neural signaling pathways (Wnt/ephrin), with supporting signals of oligodendrocyte differentiation and mechanotransduction, suggesting a CNS signaling and trafficking theme rather than a single pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072660","count":5},{"id":"GO:0035544","count":5},{"id":"GO:0035994","count":5},{"id":"GO:0016055","count":5},{"id":"GO:1900383","count":5}]},{"hash":"933913853543889505","title":"Fucosylated glycan biosynthesis","description":"The top GO terms are dominated by glycosylation and fucosylation: Lewis a epitope biosynthesis, N-glycan fucosylation, and general protein glycosylation. Immune and neural migration terms may reflect downstream effects of glycans in cell signaling and development, but the central theme across terms is the synthesis of fucose-containing glycans.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":7},{"id":"GO:0006486","count":6},{"id":"GO:0075015","count":5},{"id":"GO:0042355","count":4},{"id":"GO:0002522","count":4}]},{"hash":"1517720273816541330","title":"Developmental signaling and tissue differentiation","description":"These proteins are enriched for development and differentiation processes (myelination, heart development, myoblast differentiation, synapse assembly) and for developmental signaling pathways (hedgehog/Smoothened, cell adhesion, and PI3K-related signaling), with immune terms likely reflecting broad signaling roles rather than a shared immune function, pointing to a cluster focused on developmental signaling and tissue differentiation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042552","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0010765","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0007507","count":6}]},{"hash":"587087697871424455","title":"Neuronal synapse formation and signaling","description":"The cluster\u2019s top GO terms center on synaptic activity and neuron structure\u2014glutamate secretion, chemical synaptic transmission, dendrite development, and regulation of presynapse assembly\u2014indicating a shared role in synapse formation and function in neurons. Some terms (oligodendrocyte development, energy homeostasis) are peripheral to this core theme but may reflect broader CNS processes; overall, the dominant signal is synaptic development and signaling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014047","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0007268","count":2},{"id":"GO:1905606","count":1},{"id":"GO:0014003","count":1}]},{"hash":"168061367675739336","title":"Neuronal adhesion and synapse formation","description":"This cluster is dominated by GO terms tied to cell-cell adhesion (homophilic/heterophilic) and neural development, including synapse assembly, axonal fasciculation, and otolith morphogenesis, with signaling pathway terms like ERK and PI3K. The innate immune response term is present but less central, so the primary theme is neuronal adhesion and synaptic development.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0051965","count":10},{"id":"GO:0007413","count":10},{"id":"GO:0007156","count":10}]},{"hash":"187842864506138190","title":"Neuronal synaptic plasticity regulators","description":"The top GO terms converge on synaptic regulation and plasticity in neurons, including receptor localization to the synapse, structural plasticity, and long-term depression, with ephrin signaling supporting synaptic signaling; additional signals like mechanical stimulus response and social behavior hint at neural circuitry roles. A minority of terms map to NOD signaling, but the dominant theme remains neuronal synaptic signaling and plasticity.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":4},{"id":"GO:0051835","count":4},{"id":"GO:1901187","count":4},{"id":"GO:0070431","count":4},{"id":"GO:0070427","count":4}]},{"hash":"1141844398729760948","title":"TLR4-LPS and NLRP3 Inflammasome Signaling","description":"GO terms center on TLR4 signaling, LPS/diacyl lipopeptide detection, I-kappaB phosphorylation, inflammatory response, and NLRP3 inflammasome assembly, indicating a cohesive innate immune/inflammatory cluster; collagen/angiogenesis terms appear as minor background signals.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":4},{"id":"GO:0016525","count":3},{"id":"GO:0070430","count":3},{"id":"GO:0071727","count":3},{"id":"GO:0034142","count":3}]},{"hash":"1280720096141540345","title":"Histone methylation and chromatin regulation","description":"Based on the Top Terms, the cluster is enriched for lysine methylation (peptidyl-lysine dimethylation/monomethylation) and chromatin-related processes (nucleosome assembly, DNA-templated transcription) and ubiquitin-mediated protein turnover. Together these point to epigenetic regulation via histone modification and transcription control. Some unrelated terms (membrane transport and epithelial differentiation) appear but do not define the core theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018027","count":2},{"id":"GO:0018026","count":2},{"id":"GO:0032973","count":2},{"id":"GO:1990034","count":2},{"id":"GO:0006351","count":1}]},{"hash":"35886343288652678","title":"Membrane Transporters in Neural and Organ Development","description":"The gene set includes multiple transmembrane transport terms (sodium, phosphate, sialic acid, arabinose, 4-hydroxyphenylacetate) and a vesicle-related function (neurotransmitter loading), plus development terms for heart and kidney and neural structure regulation (dendritic spines, collateral sprouting). This points to a cluster of membrane transporters linked to neural signaling and organ development, rather than a single pathway, hence a composite label focusing on transport plus development. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048671","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0061000","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0098700","count":2}]},{"hash":"409591068684928324","title":"Mammalian Developmental Signaling and Morphogenesis","description":"The cluster includes terms tied to development and tissue shaping, such as blastocyst formation, nipple morphogenesis, axonogenesis, and tooth mineralization, along with signaling pathways (GPCR-PLC signaling, NOD1 pathway regulation) and post-translational regulation (protein ubiquitination). This combination points to proteins involved in coordinating developmental processes and morphogenesis through signaling and regulation, rather than a single narrow pathway. A few terms (e.g., obsolete terms) are less informative, but overall the theme is developmental signaling and morphogenesis.","confidence":"Medium","size":20,"edges":62,"triangles":10,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006378","count":3},{"id":"GO:0001825","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0060658","count":3},{"id":"GO:0019800","count":3}]},{"hash":"33578626286998329","title":"Ribosome biogenesis and translation","description":"Dominated by translation and ribosome biogenesis terms: translation (GO:0006412), ribosome biogenesis (GO:0042254), rRNA maturation (GO:0000462, GO:0000463) and translation initiation/termination (GO:0001731, GO:0006415). This indicates a cluster of proteins involved in ribosome assembly and protein synthesis, with a few unrelated terms like cell division and fertilization appearing less central.","confidence":"High","size":20,"edges":182,"triangles":1005,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0042254","count":8},{"id":"GO:0000462","count":6},{"id":"GO:0046677","count":4},{"id":"GO:0000463","count":3}]},{"hash":"466885362994375996","title":"Nucleobase and Purine Transport","description":"The dominant GO terms describe import/transport of nucleobases and purines across the membrane (adenine, guanine, hypoxanthine, xanthine, urate, uracil). A couple of outliers relate to protein modification or GTPase regulation, which are incidental. Overall, the cluster is best described as nucleobase/purine transporters.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035344","count":2},{"id":"GO:0070904","count":2},{"id":"GO:0015747","count":2},{"id":"GO:0098721","count":2},{"id":"GO:1903825","count":2}]},{"hash":"533896396070041373","title":"DNA Metabolism and Transcription Machinery","description":"The top GO terms point to core nucleic acid processes: DNA-templated transcription, DNA replication, DNA repair, mitotic cell cycle, and RNA processing (tRNA pseudouridine synthesis and mRNA polyadenylation). Although some neural and immune terms appear, the dominant theme is DNA/RNA metabolism and transcription/processing, suggesting these proteins broadly participate in genome maintenance and gene expression rather than a single specialized pathway.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006378","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0001963","count":2}]},{"hash":"953681667829381765","title":"mRNA splicing regulation and translation initiation","description":"This cluster shows strong signals for spliceosome-mediated mRNA processing (splicing, polyadenylation, modification) and translation initiation/reinitiation, plus stress-related mRNA stability, indicating a coordinated module of RNA processing with translation readiness.","confidence":"High","size":20,"edges":51,"triangles":94,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":9},{"id":"GO:0031047","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0000381","count":8}]},{"hash":"1816529582246269815","title":"Unknown","description":"The terms span very diverse biological contexts (exocytosis, kidney development, astrocyte activation, connective tissue remodeling, calcium/NFAT signaling, yeast mating, axon growth, muscle dynamics, polysaccharide breakdown, and glucose response) with no clear shared function or pathway linking the cluster members, making a cohesive label impractical.","confidence":"","size":20,"edges":41,"triangles":22,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045921","count":3},{"id":"GO:0072221","count":3},{"id":"GO:0048143","count":2},{"id":"GO:1905205","count":2},{"id":"GO:0033173","count":2}]},{"hash":"16056558228871986","title":"MAPK and Wnt Signaling in Development","description":"This cluster centers on signaling pathways that govern development and cell fate, highlighted by ERK/MAPK cascade components, regulation of canonical Wnt signaling, axial mesoderm formation, and control of fat cell differentiation. Additional terms point to GPCR signaling modulation, cytoskeletal organization, and phosphorylation, all aligning with developmental signaling and differentiation processes. The mix suggests proteins involved in coordinating growth, patterning, and lineage decisions rather than a single static function.","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":3},{"id":"GO:0070371","count":3},{"id":"GO:0048320","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0090090","count":2}]},{"hash":"1796800256105926515","title":"Cell Polarity and Cytoskeletal Regulation","description":"The cluster is defined by GO terms on cell polarity establishment (apical/basal polarity, cell shape), Golgi localization, and actin filament polymerization, suggesting coordinated polarity and cytoskeletal remodeling. Immune-context terms (innate immune response, engulfment of apoptotic cells) point to cytoskeletal changes during immune processes; overall, the proteins appear tied to polarity and cytoskeletal dynamics, with possible involvement in immune-related remodeling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0051683","count":4},{"id":"GO:0051835","count":4},{"id":"GO:0035641","count":4}]},{"hash":"1879570983346137891","title":"Neuronal ciliary and cytoskeletal dynamics","description":"The top GO terms point to cilium assembly, microtubule-based movement, and filopodium regulation, paired with nervous system-related processes such as spinal cord development, NMDA receptor activity regulation, and sensory perception of sound. This suggests a cluster of proteins involved in ciliary/cytoskeletal functions that support neuronal development and signaling, rather than a single, narrow pathway. A few terms (like thrombin signaling) are broad, but overall the theme centers on neuron-associated ciliary and cytoskeletal dynamics.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":2},{"id":"GO:2000310","count":2},{"id":"GO:0006924","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0021510","count":2}]},{"hash":"1047632754836964822","title":"Olfactory nerve development and proteoglycan metabolism","description":"The top terms center on olfactory system development (placode morphogenesis and nerve formation) and proteoglycan/glycosaminoglycan metabolism, suggesting a coherent theme around olfactory nerve development shaped by extracellular matrix proteoglycans, despite some noisy or obsolete terms in the set. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015014","count":4},{"id":"GO:0071699","count":4},{"id":"GO:0021628","count":4},{"id":"GO:0006508","count":3},{"id":"GO:0006486","count":3}]},{"hash":"218663150077640368","title":"Unknown","description":"The top GO terms cover neuronal spine development, hematopoietic/megakaryocyte/platelet differentiation, atrial cardiac electrophysiology, cortisol synthesis, and temperature response, with no clear shared function linking them. This lack of a cohesive biological theme makes it inappropriate to assign a single concise label.","confidence":"","size":20,"edges":29,"triangles":12,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":3},{"id":"GO:0002244","count":3},{"id":"GO:0048671","count":3},{"id":"GO:0035855","count":2},{"id":"GO:0030220","count":2}]},{"hash":"562194633099539470","title":"Cardiovascular and Neural Development","description":"This cluster centers on developmental processes in the cardiovascular system (heart development, angiogenesis, cardiac hypertrophy in response to stress) and neural biology (axonogenesis, visual perception), with additional signals related to ECM organization and transcriptional regulation that support tissue formation. The mix suggests involvement in broad developmental programs spanning heart/vasculature and nervous system rather than a single, narrow pathway. ","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0006469","count":4},{"id":"GO:0007409","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0001525","count":3}]},{"hash":"1060888006509862182","title":"Developmental Signaling and Transcription Regulation","description":"This cluster centers on developmental processes and their regulation, with GO terms for heart development, hippocampus development, and cartilage condensation. It also highlights signaling and transcription control, shown by positive regulation of ERK1/ERK2 cascade, peptidyl-serine phosphorylation, DNA-templated transcription, and mRNA processing, as well as a link to DNA damage response regulation by p53. Together, these terms suggest a coordinated developmental program where signaling pathways control gene expression during organogenesis of heart/brain structures.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033138","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0001502","count":3}]},{"hash":"1984960671425855710","title":"Neuronal ion transport and synaptic signaling","description":"The cluster centers on ion transmembrane transport (K+, Na+, Ca2+), GABA signaling, and excitatory postsynaptic potentials, with links to neural behavior and sensory processing (startle, locomotion, circadian sleep/wake, LGN development). This points to a cohesive theme of neuronal excitability and synaptic communication, with associated behavioral regulation.","confidence":"High","size":20,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071805","count":14},{"id":"GO:0098703","count":11},{"id":"GO:0001964","count":11},{"id":"GO:0045188","count":11},{"id":"GO:0035725","count":10}]},{"hash":"422022823737651865","title":"Mitochondrial Translation and Metabolism","description":"This cluster centers on mitochondrial function, with multiple proteins annotated for mitochondrial translation, fatty acid catabolic processes, and glutaminyl-tRNAGln biosynthesis via transamidation, all pointing to mitochondrial protein synthesis and energy metabolism. Other terms about ER organization and neural development appear peripheral to the core mitochondrial theme, suggesting broader cellular roles but not overriding the dominant mitochondrial signal.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":5},{"id":"GO:0043278","count":3},{"id":"GO:0021756","count":3},{"id":"GO:0009062","count":3},{"id":"GO:0070681","count":3}]},{"hash":"1902196598580972145","title":"Cytokine-driven immune activation","description":"This cluster is dominated by GO terms describing cytokine production (IL-3, GM-CSF), T cell proliferation, and responses to bacterial components (LPS), indicating a coherent theme of immune cell activation and inflammatory signaling despite some outlier terms. ","confidence":"High","size":20,"edges":161,"triangles":733,"max_degree":19,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":20},{"id":"GO:0045401","count":20},{"id":"GO:0045425","count":20},{"id":"GO:0071222","count":20},{"id":"GO:2000811","count":20}]},{"hash":"46416788234198441","title":"Redox Homeostasis and Oxidant Detoxification","description":"The top GO terms are dominated by cell redox homeostasis and cellular oxidant detoxification, suggesting a core function in managing oxidative stress. Additional terms point to growth and metabolic signaling (insulin response, growth regulation) and immune/modulatory aspects (IL-1\u03b2 regulation, nitric oxide related), implying redox signaling intersects with metabolism, growth, and immune pathways. Overall, the cluster seems centered on oxidative balance with linked metabolic and growth regulation.","confidence":"High","size":20,"edges":121,"triangles":432,"max_degree":18,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0045454","count":15},{"id":"GO:0098869","count":15},{"id":"GO:2000255","count":14},{"id":"GO:0032869","count":9},{"id":"GO:0010044","count":8}]},{"hash":"704331046501357779","title":"Cell-cycle, apoptosis, and innate immune signaling","description":"This cluster shows strong enrichment for mitotic spindle assembly (mitosis), apoptotic and pyroptotic inflammatory responses, and innate immune processes, alongside protein ubiquitination and cell-cycle regulation. Together these terms suggest a functional module that links cell division with stress-induced apoptosis/inflammation and ubiquitin-mediated signaling, with additional cytoskeletal signaling context reflected by GTPase regulation and neuronal projection development.","confidence":"Medium","size":20,"edges":8,"triangles":3,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":12},{"id":"GO:0045087","count":10},{"id":"GO:0006915","count":9},{"id":"GO:0070269","count":9},{"id":"GO:0016567","count":9}]},{"hash":"1068985673838987585","title":"Xenobiotic and chemical stress response","description":"The top GO terms indicate responses to chemical stimuli, notably cocaine and amines, along with a general cellular response to xenobiotic stimulus, suggesting the cluster centers on chemical stress sensing/response. Additional terms point to related metabolism and methylation processes, which may be ancillary or reflect broader regulatory connections rather than a single cohesive function. Overall, chemical stress response is the most representative theme, with methylation and metabolic terms providing weaker alignment. ","confidence":"Medium","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0014075","count":4},{"id":"GO:0035690","count":4},{"id":"GO:0001300","count":4}]},{"hash":"341167429900693604","title":"Cardiac development and heart morphogenesis","description":"The cluster\u2019s top GO terms cluster around heart formation and morphogenesis, including atrium and left ventricle formation, heart valve development, outflow tract morphogenesis, and regulation of heart rate, with additional signals pointing to transcriptional regulation during cardiac development. This suggests a coherent theme of cardiac developmental processes. ","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":18},{"id":"GO:0045663","count":17},{"id":"GO:0061309","count":17},{"id":"GO:0035910","count":17},{"id":"GO:0021892","count":17}]},{"hash":"649917414365146923","title":"Developmental transcriptional regulation","description":"This cluster centers on transcriptional control (DNA-templated transcription and RNA polymerase II) combined with tissue-specific differentiation processes across multiple organ systems (pancreas, skeletal muscle, cortex interneurons, spinal motor neurons, hair cycle, labyrinthine morphogenesis) and circadian regulation. The convergence on gene expression control in development across diverse tissues justifies the label as a cohesive developmental transcriptional program.","confidence":"Medium","size":20,"edges":185,"triangles":1060,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0006366","count":9},{"id":"GO:0031018","count":8},{"id":"GO:2001016","count":8},{"id":"GO:0021892","count":7}]},{"hash":"1135431030606505634","title":"Vascular Inflammation, Coagulation, and Angiogenesis","description":"The top GO terms cluster around vascular hemostasis and inflammatory remodeling: complement activation, platelet activation, blood coagulation, plasminogen activation/fibrinolysis, and positive regulation of angiogenesis. Additional terms on cell-matrix adhesion and receptor tyrosine kinase signaling support endothelial\u2013platelet interactions and extracellular matrix remodeling. A UV-B response term is present but likely reflects a broader stress response; overall, the module centers on vascular inflammation and coagulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":10},{"id":"GO:0007160","count":9},{"id":"GO:0007171","count":8},{"id":"GO:0031639","count":8},{"id":"GO:0045766","count":8}]},{"hash":"176842587902604434","title":"Developmental and Immune MAPK Signaling","description":"The cluster centers on MAPK/ERK pathway regulation (positive regulation of ERK1/2 cascade) combined with broad regulatory functions (DNA-templated transcription, nuclear export) and diverse developmental and immune/inflammatory processes (multicellular organism development, heart development, LPS/prostaglandin responses, macrophage chemotaxis, sensory/visual perception). This pattern suggests a single regulatory module where MAPK signaling coordinates development with innate immune and inflammatory responses, possibly spanning neuronal, cardiovascular, and immune contexts.","confidence":"Medium","size":20,"edges":66,"triangles":81,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0007275","count":10},{"id":"GO:0070374","count":9},{"id":"GO:0006351","count":9},{"id":"GO:0046827","count":9}]},{"hash":"1983325292955370330","title":"Cell death and ubiquitin signaling with innate immunity","description":"The cluster is dominated by GO terms for apoptotic and pyroptotic processes and innate immune response, along with protein ubiquitination, pointing to a group of proteins involved in programmed cell death and inflammation regulated by ubiquitin signaling. The presence of mitotic spindle assembly as a top term suggests some members also participate in cell division, but the recurring death and innate-immunity terms indicate the primary theme is death signaling modulated by ubiquitin in immune contexts.","confidence":"Medium","size":20,"edges":172,"triangles":904,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":18},{"id":"GO:0006915","count":17},{"id":"GO:0070269","count":17},{"id":"GO:0016567","count":17},{"id":"GO:1990001","count":17}]},{"hash":"326046019339326942","title":"Unknown","description":"The GO terms are highly diverse, spanning visual and pain perception, temperature responses, development (heart, nipple), behavior (operant conditioning), and renal function, with no clear shared pathway or function linking the proteins. Because no cohesive theme emerges, a specific label cannot be confidently assigned beyond Unknown.","confidence":"","size":20,"edges":7,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0007507","count":16},{"id":"GO:0019233","count":16}]},{"hash":"512464328380439307","title":"Cardiac Ion Transport and Myocyte Excitability","description":"This cluster is dominated by GO terms tied to metal ion transport (calcium and manganese) and cardiac muscle cell action potentials, suggesting a shared function in cardiac electrophysiology and ion handling; a few terms like skin development are present but less central.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051262","count":4},{"id":"GO:0006828","count":4},{"id":"GO:0098703","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0015015","count":4}]},{"hash":"685386178592853598","title":"Innate Immune Activation and Regulated Cell Death","description":"The top GO terms cluster around innate immune response, inflammatory pathways (including pyroptosis), phagocytosis, Fc receptor signaling, and regulation of macrophage/NK cell activity, plus protein ubiquitination. While there is a less-specific term for mitotic spindle assembly, the dominant signal is innate immunity and inflammatory cell death processes, suggesting a coherent functional group of immune activation and controlled cell death. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":10},{"id":"GO:1990001","count":9},{"id":"GO:0090307","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0016567","count":9}]},{"hash":"1595109525786680169","title":"Nervous system development and axon guidance","description":"The proteins show strong enrichment for neural-related processes: peripheral nervous system development, nerve impulse transmission, axon region localization (juxtaparanode), and Roundabout (ROBO/Slit) signaling, along with Rho-regulated cytoskeletal dynamics and synapse assembly. These collectively point to neural development, axon guidance, and synapse formation as the core theme, with other terms being supportive but less central.","confidence":"High","size":20,"edges":167,"triangles":792,"max_degree":19,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":12},{"id":"GO:0045663","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0071206","count":10},{"id":"GO:0001525","count":10}]},{"hash":"1871235276762561411","title":"Immune Signaling and Development","description":"The top GO terms point to immune signaling (dendritic cell and mast cell cytokine production, Fc receptor signaling, and STAT pathway activation) alongside developmental and growth-related processes (myelination, skeletal system development, angiogenesis) and PI3K signaling. This suggests a cluster of proteins involved in coordinating signaling cascades that drive immune responses and tissue development.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":9},{"id":"GO:0042552","count":8},{"id":"GO:0051965","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0001501","count":7}]},{"hash":"2232614054971385826","title":"Membrane Sugar and Ion Transporters","description":"Top GO terms reveal transmembrane transport for sugars, ions, and metabolites, suggesting a cluster of membrane transport proteins. Anomalous terms like heart development and neurotransmitter loading may be annotation noise, but the dominant signal is substrate transport across membranes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0098700","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0015751","count":2},{"id":"GO:0015707","count":2}]},{"hash":"438803494857716881","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":14},{"id":"GO:0051607","count":14},{"id":"GO:0043029","count":13},{"id":"GO:0035372","count":12},{"id":"GO:0042787","count":12}]},{"hash":"1392432622609099425","title":"Neural signaling and autonomic regulation","description":"This cluster centers on nervous system processes, including learning-related neural functions (visual learning, operant conditioning), enteric nervous system development, and chemokine-mediated signaling in neural contexts, plus autonomic outputs such as norepinephrine/epinephrine\u2013driven vasoconstriction and heart rate regulation, with heat generation as a downstream physiological response. A few terms relate to broader physiological regulation (renal sodium handling, developmental morphogenesis), but the prevailing theme is neural signaling and autonomic control of body functions.","confidence":"Medium","size":20,"edges":17,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":14},{"id":"GO:0040015","count":14},{"id":"GO:0060658","count":13},{"id":"GO:0035106","count":13},{"id":"GO:0035815","count":13}]},{"hash":"132782780089205782","title":"Extracellular matrix remodeling and bone resorption","description":"The top GO terms point to breakdown and remodeling of extracellular matrix components: basement membrane disassembly, collagen catabolic process, and bone resorption, with related tissue remodeling processes like decidualization and bradykinin catabolic activity. While there are broader regulatory or signaling terms present (e.g., regulation of catalytic activity, Wnt-related notes, thyroid hormone response), the strongest and most coherent signal across the terms is ECM degradation/remodeling, suggesting these proteins function together in ECM remodeling and bone/tissue turnover. Confidence: Medium","confidence":"","size":20,"edges":68,"triangles":149,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0050790","count":11},{"id":"GO:0001913","count":11},{"id":"GO:0034769","count":11},{"id":"GO:0030574","count":11},{"id":"GO:0035593","count":11}]},{"hash":"1834002043694622681","title":"Platelet Aggregation and Coagulation","description":"Based on the prominence of GO terms related to platelet aggregation (GO:0070527) and its negative regulation (GO:0090331), plus collagen fibril organization (GO:0030199) and blood coagulation/fibrin clot formation (GO:0072378), the cluster is best characterized by hemostasis and platelet\u2013ECM interactions. Complement activation (lectin pathway) and cellular responses (IL-1, apoptosis recognition) fit within the inflammatory/vessel injury context that accompanies coagulation. Some terms (UV-B response, axon regeneration) are peripheral but do not override the central coagulation theme. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090331","count":9},{"id":"GO:0030199","count":9},{"id":"GO:0001867","count":8},{"id":"GO:0071347","count":6},{"id":"GO:0072378","count":6}]},{"hash":"307904508058366816","title":"Immune-angiogenic signaling and extracellular remodeling","description":"The GO terms cluster around immune-activation (complement/lectin pathway), regulation of angiogenesis, plasminogen activation, and cell-surface localization with apoptotic cell clearance, indicating a coherent theme of immune-vascular signaling and extracellular remodeling; a few neuronal signaling terms are present but do not define the core function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0035641","count":5},{"id":"GO:0044320","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0071354","count":5}]},{"hash":"836757868440581127","title":"Enteric nervous system signaling and gut motility","description":"The cluster\u2019s top GO terms cluster around enteric nervous system development, peristalsis, and gut motility, with related sensory (pain) and inflammatory signaling. Additional terms for xenobiotic and temperature responses and ERK signaling suggest broader stress- and signaling-related roles that connect neural control of the gut with sensory and immune responses. This combination points to proteins involved in enteric neural regulation and associated signaling rather than a single metabolic pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0030432","count":4},{"id":"GO:0048484","count":4},{"id":"GO:0070374","count":4}]},{"hash":"322971345849588808","title":"RNA Processing and Translation Control","description":"This cluster is enriched for mRNA splicing, transport, and ribosome biogenesis, along with formation of the translation preinitiation complex and TORC1 signaling, all pointing to regulation of gene expression at the RNA and translation levels. Some terms like gonad development and GPCR signaling appear peripheral, but the core theme centers on RNA processing and protein synthesis control.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038202","count":4},{"id":"GO:0008584","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0051028","count":3}]},{"hash":"1384818414631446670","title":"Immune response and angiogenesis regulation","description":"The top GO terms indicate immune defense (defense response to virus, innate and adaptive immune responses) alongside regulation of angiogenesis (positive and negative), with accompanying signaling pathways (ERK cascade, NF-kappaB-related activity). This suggests a cluster of proteins that coordinate immune responses with vascular remodeling, rather than a single isolated process. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043536","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0002250","count":2},{"id":"GO:0001525","count":2}]},{"hash":"113717530952649589","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0043029","count":15},{"id":"GO:0051607","count":15},{"id":"GO:0061158","count":15},{"id":"GO:0033209","count":15}]},{"hash":"2238087182207960582","title":"Adaptive immune activation and T cell signaling","description":"Dominant GO terms point to adaptive immunity: negative regulation of T cell receptor signaling, immunoglobulin production, CD40 signaling, and STAT phosphorylation, indicating proteins involved in lymphocyte activation and humoral responses. A couple of terms on megakaryocyte development and atrial cardiomyocyte action potential may reflect shared regulatory components or annotation noise, but the core theme is adaptive immune signaling. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":4},{"id":"GO:0002377","count":4},{"id":"GO:0086014","count":4},{"id":"GO:0035855","count":4},{"id":"GO:0042511","count":4}]},{"hash":"2031489923747275517","title":"Neuronal development and synapse formation","description":"The dominant GO terms cluster around CNS neuron development and synaptogenesis, including positive regulation of synapse assembly, dendritic spine morphogenesis, CNS projection neuron axonogenesis, and corpus callosum development, with related axon fasciculation terms. Some terms (immune activation, telomere maintenance, Sho1 osmosensor pathway) may be background noise, but the core signal strongly supports neural development and synapse formation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0071372","count":5},{"id":"GO:0022038","count":5},{"id":"GO:0050798","count":4},{"id":"GO:0021952","count":4}]},{"hash":"1182360605506580873","title":"Motile cilia and spermatid development","description":"The top GO terms cluster around cilium/axoneme assembly and movement (axoneme assembly, cilium movement, motile cilium assembly) and spermatid development, indicating a core role in flagellar/ciliary formation during spermatogenesis. Less central terms include innate immune response and hydrogen peroxide response, which introduces some functional noise. The absence of edges suggests heterogeneity, but the dominant cilium/spermatid signals support a cohesive theme. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0035082","count":1},{"id":"GO:0060294","count":1},{"id":"GO:0044458","count":1}]},{"hash":"1556679916613740041","title":"Cell Signaling and Development","description":"The GO terms point to a common theme of signaling and developmental processes, including integrin-mediated signaling, GPCR signaling regulation, and dendritic spine morphogenesis, alongside broader developmental topics like skin development and phagocytic clearance of apoptotic cells. The presence of cell-cycle and xenobiotic response terms suggests general cellular regulation within a developmental context rather than a single, narrow pathway. A few terms (e.g., sporulation) may reflect annotation noise, but the dominant pattern is signaling and development. Therefore, a concise label capturing signaling-driven development is appropriate.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0040037","count":3},{"id":"GO:0043652","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0000278","count":3}]},{"hash":"585309823920466381","title":"Splicing Regulation and mRNA Maturation","description":"The cluster\u2019s top GO terms center on spliceosome-mediated mRNA processing, including both positive and negative regulation of splicing, plus related post-transcriptional steps such as mRNA stability, export, modification, and translation initiation. This points to a cohesive module governing RNA processing and export and the initiation of translation, rather than transcriptional control.","confidence":"High","size":19,"edges":153,"triangles":713,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":15},{"id":"GO:0010610","count":15},{"id":"GO:0048025","count":15},{"id":"GO:0045292","count":15},{"id":"GO:0031047","count":15}]},{"hash":"1122101892907697764","title":"Retroviral replication, integration, and latency","description":"The top GO terms concentrate on DNA replication, recombination, base-excision repair, RNA-templated DNA biosynthesis, and DNA integration, with explicit references to proviral latency and viral entry into the host nucleus, pointing to retroviral reverse transcription and genome integration into host DNA followed by latency. Some terms about virus-host interactions and suppression of RNAi processing further support a viral life cycle theme, despite a few general DNA maintenance terms. ","confidence":"High","size":19,"edges":140,"triangles":539,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0006310","count":7},{"id":"GO:0006284","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0075732","count":6}]},{"hash":"1918648967285798847","title":"Immune Activation and Cytokine Production","description":"The dominant terms describe immune signaling, including cytokine production (IL-3, GM-CSF), T cell activation, and LPS response, pointing to an immune activation cluster. A few terms such as pollen recognition or cocaine response seem less related and may reflect broader or cross-annotation noise, but they do not override the central immune theme. Overall, the proteins likely function together in immune regulation and inflammatory responses.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":19},{"id":"GO:0045401","count":19},{"id":"GO:0045425","count":19},{"id":"GO:0071222","count":19},{"id":"GO:2000811","count":19}]},{"hash":"2205456573927900835","title":"Autophagy and Ubiquitin-like Modifications","description":"The cluster is dominated by autophagy-related terms (macroautophagy, mitophagy, Cvt pathway) and multiple ubiquitin-like post-translational modifications (sumoylation, neddylation, urmylation) plus C-terminal lipidation\u2014together implying a module of autophagy regulation governed by ubiquitin-like modifiers. A secondary, less central term (thiamine diphosphate biosynthesis) appears incidental. ","confidence":"High","size":19,"edges":155,"triangles":739,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":6},{"id":"GO:0018192","count":5},{"id":"GO:0051726","count":5},{"id":"GO:0016236","count":5},{"id":"GO:0032258","count":5}]},{"hash":"1057588990883877619","title":"Vertebrate Development","description":"The top GO terms point to diverse vertebrate developmental processes\u2014kidney and duct development, spinal cord and hair cell differentiation, and lymph vessel morphogenesis\u2014alongside general RNA processing steps that support gene expression during development. This suggests the proteins cluster around embryonic tissue formation and morphogenesis rather than a single, narrow pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":2},{"id":"GO:0035196","count":2},{"id":"GO:0072218","count":1},{"id":"GO:0031659","count":1},{"id":"GO:0072205","count":1}]},{"hash":"1896696533342075625","title":"Amino acid biosynthesis and metabolism","description":"The cluster shows several GO terms tied to amino acid biosynthesis (isoleucine, tryptophan, cysteine) and related metabolic steps (pyruvate biosynthesis, amine catabolic process), suggesting a core theme of amino acid production and turnover. There are a few outliers (mitochondrial translation, protein homotetramerization, a morphine-response term) that seem ancillary, but the strongest signal is amino acid biosynthesis, supporting a function centered on amino acid metabolism.","confidence":"Medium","size":19,"edges":87,"triangles":129,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009097","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0043278","count":5},{"id":"GO:0042866","count":5},{"id":"GO:0051289","count":5}]},{"hash":"547080426884633552","title":"P450-Mediated Steroid and Xenobiotic Metabolism","description":"The terms cluster around cytochrome P450 pathways: omega-hydroxylation, epoxygenation, and multiple biosynthetic/catabolic processes for steroids (testosterone, cortisol) and bile acids, plus retinoic acid catabolism. This points to a group of P450 enzymes driving diverse metabolic pathways, i.e., steroid and xenobiotic metabolism. A few outliers (eye development) exist but do not change the core theme.","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097267","count":16},{"id":"GO:0019373","count":16},{"id":"GO:0061370","count":16},{"id":"GO:0009822","count":16},{"id":"GO:0034651","count":16}]},{"hash":"1329912563900059271","title":"Mitotic progression and apoptosis with ubiquitin signaling","description":"The cluster centers on cell division and mitosis (mitotic spindle assembly, cell division) and apoptotic pathways, with notable involvement of ubiquitin-mediated regulation (protein ubiquitination, ubiquitin-dependent ERAD). The presence of pyroptotic inflammatory and innate immune terms suggests inflammatory cell death contexts, but the strongest cohesive signal is the linkage between mitosis, programmed cell death, and ubiquitin signaling. This makes a label focusing on mitotic progression, apoptosis, and ubiquitin regulation most representative.","confidence":"Medium","size":19,"edges":10,"triangles":0,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0090307","count":13},{"id":"GO:0006915","count":8},{"id":"GO:0070269","count":8},{"id":"GO:0016567","count":8},{"id":"GO:1990001","count":8}]},{"hash":"639175508836552866","title":"Immune, Coagulation, and Angiogenesis Signaling","description":"These proteins show enrichment for immune and coagulation processes (complement activation via lectin pathway; plasminogen activation; fibrinolysis; blood coagulation) together with inflammatory signaling (adaptive immune response; IL-1 response; ERK cascade) and vascular remodeling (angiogenesis, cell-matrix adhesion). This points to a coordinated inflammatory-coagulative-angiogenic program rather than a single pathway, so the label captures the shared theme across the GO terms.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0031639","count":8},{"id":"GO:0045766","count":8},{"id":"GO:0002250","count":8},{"id":"GO:0042730","count":8}]},{"hash":"1408004328898932565","title":"ECM remodeling and inflammatory barrier signaling","description":"The top GO terms cluster around extracellular matrix organization (fibronectin fibril organization), barrier formation and integrity (tricellular tight junction assembly, endothelial proliferation), and immune/inflammatory processes (acute inflammatory response, cytokine production, Th17 regulation). Enzymatic/modification terms (zymogen activation, peptidyl-lysine oxidation) and protein assembly (homotrimerization) further support remodeling of the ECM and barrier structures in an inflammatory context. This combination suggests a coherent theme of ECM remodeling coupled with barrier integrity and inflammatory signaling.","confidence":"High","size":19,"edges":28,"triangles":13,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0090103","count":14},{"id":"GO:0001935","count":14},{"id":"GO:1904274","count":14},{"id":"GO:1900017","count":14},{"id":"GO:0031638","count":14}]},{"hash":"1656821665634853182","title":"Innate Immune Signaling and Pyroptosis","description":"The cluster is enriched for innate immune and inflammatory pathways: innate immune response, Fc-epsilon receptor signaling, pyroptotic inflammatory response, CD40 signaling, and ubiquitination. There are also apoptotic and cardiac-related terms that may reflect broader multifunctionality, but the central pattern is immune activation and inflammatory cell death processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":11},{"id":"GO:0038095","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0016567","count":9},{"id":"GO:1990001","count":8}]},{"hash":"1260365284110721248","title":"Mitochondrial metabolite transporters","description":"Top GO terms indicate transmembrane transport of various cofactors and metabolites (fatty acids, PLP, ornithine, nucleotides, TPP, heme, phosphate) with explicit mitochondria-related terms like mitochondrial L-ornithine transport, suggesting proteins functioning as mitochondrial membrane transporters.","confidence":"High","size":19,"edges":19,"triangles":13,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":17},{"id":"GO:0031921","count":17},{"id":"GO:0000066","count":17},{"id":"GO:0030302","count":17},{"id":"GO:0030974","count":17}]},{"hash":"1335685719883848769","title":"Synaptic signaling and small GTPase regulation","description":"The top GO terms cluster around neuronal communication and signaling: synapse assembly and long-term potentiation point to neuronal synaptic processes, while small GTPases (Rho, Ras, and related signaling) indicate regulation of signaling cascades. Inositol trisphosphate biosynthesis ties into intracellular calcium signaling at synapses, supporting a cohesive theme of synaptic signaling and modulation by GTPase pathways. Some peripheral terms (B cell differentiation, tight junctions) are present but do not contradict the central synaptic/ signaling theme.","confidence":"Medium","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032959","count":3},{"id":"GO:0038028","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0002316","count":3}]},{"hash":"2219496330455430000","title":"Rho GTPase signaling and actin remodeling","description":"Based on top GO terms, this cluster centers on Rho GTPase signaling, regulation of GTPase activity, and actin cytoskeleton organization, with links to PKC signaling and cell migration. The shared themes point to cytoskeletal remodeling and motility regulated by Rho-family GTPases, even though the proteins are not shown as an interaction network here. Thus the label captures the common function among the proteins.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007266","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0070528","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0051531","count":2}]},{"hash":"966957104111175270","title":"Opsin Signaling and GPCR-Calcium-CAMP Modulation","description":"The terms point to vision-related signaling, with visual perception and regulation of opsin-mediated signaling. Additional terms highlight GPCR signaling, activation of adenylate cyclase, calcium release, and phosphorylation, suggesting a cohesive GPCR-cAMP-Ca2+ signaling module potentially tied to photoreceptor function. Some terms (heart development, L-arginine catabolic process) appear less central and may reflect broader annotations or noise.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0022400","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0007507","count":2}]},{"hash":"147598991855747083","title":"Adaptive Immune Signaling and Cytoskeletal Remodeling","description":"The top GO terms point to adaptive immune signaling (T and B cell receptor pathways, IL-2 production) paired with cytoskeletal and adhesion dynamics (Rho signaling, integrin signaling, podosome assembly). This suggests a module of proteins governing lymphocyte activation and cytoskeletal remodeling during immune responses.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0071560","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0007229","count":3}]},{"hash":"1479459102935978338","title":"Membrane trafficking and apoptotic signaling","description":"The Top Terms cluster around apoptosis, autophagy regulation, and several membrane trafficking processes (ER targeting, Golgi retention, membrane fission, ESCRT-mediated budding). These reflect membrane remodeling and protein sorting/signaling that connect cell fate decisions with intracellular trafficking and signaling pathways (e.g., insulin signaling, synaptic plasticity). This suggests a coherent theme of intracellular membrane dynamics governing signaling and cell fate.","confidence":"Medium","size":19,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:1902902","count":4},{"id":"GO:0060292","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0035855","count":3}]},{"hash":"2215044896458545983","title":"Epithelial barrier formation and vesicle trafficking","description":"The GO terms cluster around epithelial barrier maintenance and membrane trafficking: establishment of epithelial/endothelial barriers, epithelial cell polarity, exocytosis, and transepithelial transport, with Rho-mediated regulation of signaling affecting cytoskeleton and junctions. These together point to a coherent theme of epithelial barrier integrity and vesicle trafficking.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000009","count":2},{"id":"GO:0090557","count":2},{"id":"GO:0006887","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0070634","count":2}]},{"hash":"1384147854128078790","title":"Proteoglycan biosynthesis and metabolism","description":"The dominant GO terms are about synthesis and metabolism of proteoglycans, notably heparan sulfate, chondroitin sulfate, and dermatan sulfate, pointing to a proteoglycan/ECM biosynthetic role with developmental links (e.g., chondrocyte development, ureteric bud formation). The term set is cohesive around glycosaminoglycan production rather than a single enzyme activity.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":2},{"id":"GO:0030202","count":2},{"id":"GO:0015014","count":2},{"id":"GO:0033037","count":2},{"id":"GO:0015768","count":2}]},{"hash":"1890624456523360778","title":"Nuclear transport and transcription regulation proteins","description":"Based on the top GO terms, several entries relate to moving proteins and RNA into the nucleus (NLS-bearing import, mRNA transport) and to transcriptional regulation (RNA polymerase III), with supporting signaling links to NF-kappaB. While some terms are broader or peripheral (e.g., GTPase regulation, synaptic potentiation), the core theme centers on nuclear transport and gene expression control, suggesting a cohesive cluster of nuclear transport/transcription regulators.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007205","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0071230","count":2},{"id":"GO:0045945","count":2}]},{"hash":"1274499495190708087","title":"Signaling and Metabolic Regulation","description":"This cluster centers on signaling pathways, highlighted by positive regulation of blood pressure, positive regulation of Rho signaling, and adenylate cyclase-activating GPCR signaling, suggesting roles in vascular and cellular signal transduction. The prominent electron transport chain and thermogenesis terms point to energy metabolism and metabolic regulation accompanying these signaling processes. Some terms (nipple morphogenesis, operant conditioning) are less directly related, indicating a broader, multi-functional protein set. Overall, the label captures a core theme of signaling intertwined with metabolism, but the diverse terms reduce specificity.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":16},{"id":"GO:0035025","count":16},{"id":"GO:0010579","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0071502","count":12}]},{"hash":"76572630648855154","title":"Neural and Immune Development Signals","description":"This cluster mixes neural development terms (neurogenesis, axon guidance/extension, smoothened signaling) with immune differentiation and regulation (antigen processing via MHC I, CD8+ T cell proliferation, NK cell cytotoxicity regulation, GM-CSF and IL-3 production) and myoblast differentiation. The unifying theme appears to be broad developmental signaling affecting multiple lineages, suggesting neural-immune development signaling as the best concise label rather than a single specific function.","confidence":"Medium","size":19,"edges":63,"triangles":90,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042590","count":4},{"id":"GO:0007224","count":3},{"id":"GO:0045663","count":3},{"id":"GO:0007411","count":3},{"id":"GO:0002859","count":3}]},{"hash":"2237132368060546020","title":"Innate Immune Signaling and Leukocyte Recruitment","description":"The top GO terms cluster around innate immune recognition and signaling (complement activation via the lectin pathway, Fc-gamma receptor signaling, C-type lectin receptor signaling) and leukocyte trafficking (leukocyte tethering/rolling, NK cell chemotaxis regulation), suggesting a theme of immune activation and recruitment. A couple terms like metanephric development appear peripheral. Overall, the dominant immune-related terms support labeling this as innate immune signaling with leukocyte recruitment.","confidence":"High","size":19,"edges":44,"triangles":24,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":19},{"id":"GO:2000502","count":19},{"id":"GO:0001867","count":19},{"id":"GO:0050901","count":19},{"id":"GO:0038094","count":19}]},{"hash":"2084574728180310572","title":"Steroid and Xenobiotic Metabolism","description":"Based on GO terms such as estrogen catabolic process, bile acid catabolic process, catecholamine metabolic process, xenobiotic metabolic process, and regulation of angiotensin levels in blood, the cluster points to proteins involved in degradation/processing of hormones and exogenous compounds. Some terms are obsolete biosynthetic processes, which are less informative, but the remaining terms suggest a metabolic theme centered on steroid-related and xenobiotic pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":9},{"id":"GO:0030206","count":9},{"id":"GO:0006711","count":5},{"id":"GO:0002002","count":5},{"id":"GO:0006584","count":5}]},{"hash":"1923029295603043762","title":"Inflammation signaling and IL-6 regulation","description":"This cluster is dominated byGO terms tied to immune and inflammatory signaling, including inflammatory response, response to lipopolysaccharide, regulation of interleukin-6 production, and negative regulation of inflammatory response, plus a note on GTPase activity regulation. While a few entries touch on non-immune processes (e.g., epithelial transport, developmental/behavioral terms), the core pattern points to inflammation and cytokine signaling as the shared theme.","confidence":"Medium","size":19,"edges":18,"triangles":0,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0048148","count":4},{"id":"GO:0032675","count":4},{"id":"GO:0050728","count":4}]},{"hash":"2150776633563654260","title":"Ubiquitin-Proteasome Regulation with Circadian and Immune Roles","description":"The top GO terms cluster around ubiquitin-dependent protein catabolism (including polyubiquitination and SCF-dependent proteasomal pathways), plus regulation of circadian rhythm and innate immune/defense responses. The co-occurrence suggests a module of proteins involved in tagging and degrading substrates\u2014adjusting clock components and immune signaling\u2014linked to cell-cycle\u2013related processes such as microtubule dynamics and spindle assembly that can be influenced by proteolysis. Therefore a label focusing on ubiquitin-mediated proteolysis with circadian/immune connections is appropriate.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0000209","count":9},{"id":"GO:0042752","count":9},{"id":"GO:0051607","count":8},{"id":"GO:0045087","count":8}]},{"hash":"483020360046770118","title":"Cardiac Development and Electrical Signaling","description":"This cluster shows multiple GO terms tied to heart development and electrophysiology, including right atrium morphogenesis, regulation of cardiac action potential depolarization, and electrical coupling, suggesting a cohesive focus on cardiac differentiation and heart-wide electrical communication. Some terms (e.g., oligodendrocyte differentiation, pain response) appear tangential, but the core pattern aligns with cardiac development and function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":4},{"id":"GO:1900827","count":4},{"id":"GO:0072660","count":4},{"id":"GO:0035994","count":4},{"id":"GO:0010650","count":4}]},{"hash":"906436350459187118","title":"Axon guidance and neural crest migration","description":"This cluster is dominated by GO terms relating to axon pathfinding and neural crest\u2013driven peripheral nervous system development (semophorin-plexin signaling, sympathetic neuron guidance, branchiomotor/trigeminal nerve organization, neural crest migration, and neuron projection extension), suggesting a cohesive theme of axon guidance and neural development.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0043031","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0097491","count":4},{"id":"GO:0036486","count":4}]},{"hash":"808490801849063684","title":"Nuclear Transport and Transcription Regulation","description":"The top GO terms include DNA-templated transcription and intracellular protein transport, plus positive regulation of protein export from the nucleus and regulation of NFAT signaling, which together point to nuclear-cytoplasmic transport and transcription control as the core theme. Some terms (peptide pheromone export, bacteriocin transport) hint at secretion processes more typical of bacteria, but they appear as outliers rather than the main driver of the cluster, suggesting a predominantly nuclear transport/transcription regulatory theme with mixed annotations. Overall, the cluster is best described by a nuclear transport and transcription regulation focus, with moderate confidence due to the mixed outlier terms.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051534","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0046007","count":2},{"id":"GO:0046827","count":2}]},{"hash":"1147077947449474057","title":"Photoreception and GPCR signaling","description":"Dominant themes are GPCR signaling and photoreception (opsin signaling, adenosine receptors, phototaxis) with supporting cGMP biosynthesis; this points to a cohesive sensory signaling role. A few terms like oocyte maturation regulation are less clearly related.","confidence":"Medium","size":18,"edges":60,"triangles":48,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1900194","count":2},{"id":"GO:0006182","count":2},{"id":"GO:0052565","count":2},{"id":"GO:0032026","count":2},{"id":"GO:0016056","count":2}]},{"hash":"238326857206992446","title":"Diverse transmembrane transporters","description":"The prominent GO terms all point to transmembrane transport of diverse substrates (vitamins, xenobiotics, sugars, ions) and vesicular neurotransmitter loading, indicating a cohesive group of transporter proteins with broad substrate scope rather than a single substrate-specific function.","confidence":"High","size":18,"edges":133,"triangles":562,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":18},{"id":"GO:0006855","count":18},{"id":"GO:0042891","count":15},{"id":"GO:0042908","count":14},{"id":"GO:0071805","count":14}]},{"hash":"480372824119432190","title":"ECM remodeling and organ morphogenesis","description":"The top terms cluster around extracellular matrix remodeling (collagen fibril organization, plasminogen activation), vascular/lymphatic development (negative regulation of angiogenesis, lymph vessel morphogenesis), and organ morphogenesis (metanephric tubule development). Together these indicate a functional theme of ECM-mediated remodeling guiding kidney and vascular development. A complement activation term is present but not central to this theme, and a few other terms (like synaptic transmission) are less representative. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0034394","count":4},{"id":"GO:0051968","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0072237","count":4}]},{"hash":"2167434908889533205","title":"Male reproductive development and steroid signaling","description":"The top GO terms cluster around male sex differentiation, prostate gland development, and steroid hormone receptor complex assembly, indicating a core theme of androgen/steroid signaling in male development; other terms (interferon response, snoRNP assembly, ubiquitination) appear as incidental annotations, not central to the main function of the cluster.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0030850","count":7},{"id":"GO:0006463","count":7},{"id":"GO:0046661","count":7},{"id":"GO:0071357","count":6}]},{"hash":"1003906738538050685","title":"Innate Immune Cell Death and Ubiquitination","description":"The cluster is dominated by GO terms tied to apoptotic and pyroptotic cell death, ubiquitination as a regulatory mechanism, and innate immune response. Additional terms point to host-pathogen interactions and immune signaling (CD40 pathway, cytotoxic susceptibility), suggesting a cohesive theme around innate defense coupled with regulated cell death. A single outlier term on mitotic spindle assembly does not override the core pattern. Confidence: High","confidence":"","size":18,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":14},{"id":"GO:0070269","count":14},{"id":"GO:0016567","count":14},{"id":"GO:1990001","count":14},{"id":"GO:0045087","count":14}]},{"hash":"667706621832459882","title":"Oxidative stress detoxification and DNA repair","description":"This cluster is dominated by terms related to detoxification of cellular oxidants and redox balance (cellular oxidant detoxification, glutathione metabolism, toxin catabolic processes) along with DNA repair (nucleotide-excision repair) and stress responses (response to starvation, aluminum ion). While there are also terms tied to calcium signaling and oligodendrocyte development, the strongest signal is a co-association of redox/ detox pathways with genome maintenance, suggesting a stress-response and detoxification-focused cluster.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":17},{"id":"GO:0042594","count":13},{"id":"GO:0009407","count":13},{"id":"GO:0006289","count":13},{"id":"GO:0006749","count":13}]},{"hash":"2249883021830979768","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0072752","count":1},{"id":"GO:0034414","count":1},{"id":"GO:0006396","count":1},{"id":"GO:1990928","count":1}]},{"hash":"518042759205793206","title":"Innate immune signaling and leukocyte-vascular interactions","description":"The cluster is dominated by innate immune pathways (complement activation via lectin pathway, C-type lectin receptor signaling, and Fc-gamma receptor signaling) plus processes related to leukocyte recruitment (tethering/rolling) and platelet activation, pointing to coordinated immune recognition and leukocyte-vasculature interactions. A few terms about vascular development appear peripherally, but the core theme is innate immune signaling with leukocyte trafficking and vascular involvement.","confidence":"High","size":18,"edges":25,"triangles":15,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":13},{"id":"GO:0072218","count":12},{"id":"GO:2000502","count":12},{"id":"GO:0050901","count":12},{"id":"GO:0038094","count":12}]},{"hash":"1695483333825465674","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042403","count":4},{"id":"GO:0050427","count":4},{"id":"GO:0071502","count":3},{"id":"GO:0098914","count":3},{"id":"GO:0002024","count":3}]},{"hash":"457437444769734839","title":"Membrane Transporters and Vesicle Trafficking","description":"The top GO terms are dominated by transmembrane transport activities for a range of ions and small molecules (sodium, potassium, nitrite, nitrate, galactose, arabinose, sialic acid, 4-hydroxyphenylacetate) and related substrates, plus terms tied to vesicle loading/trafficking (neurotransmitter loading, GTPase regulation). This pattern suggests a cluster of membrane transporter proteins with relevance to vesicle trafficking or secretion pathways, hence the label.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0098700","count":3},{"id":"GO:0015739","count":3}]},{"hash":"1879393318628513912","title":"Rac\u2011driven actin remodeling and cell migration","description":"The dominant GO terms point to actin cytoskeleton organization, lamellipodium assembly, Rac/small GTPase signaling, and cell migration, indicating a shared function in actin\u2011driven motility. Immune and developmental terms appear secondary but reflect broader roles of these pathways. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":4},{"id":"GO:0043113","count":3},{"id":"GO:0098761","count":3},{"id":"GO:0090557","count":3},{"id":"GO:0001865","count":3}]},{"hash":"414773385267879149","title":"Ubiquitin-Dependent Protein Degradation and Signaling","description":"This cluster is dominated by GO terms related to ubiquitin-dependent proteolysis (including the multivesicular body sorting pathway and autoubiquitination) and ubiquitin signaling (K63-linked ubiquitination), with additional ties to related signaling pathways (GTPase activity, JNK cascade). While a few terms touch on splicing or astrocyte development, the strongest, recurring theme is ubiquitin-mediated protein turnover and signaling, possibly linked to endosomal sorting and stress signaling. ","confidence":"High","size":18,"edges":122,"triangles":469,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0046597","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0043162","count":2},{"id":"GO:0070534","count":2}]},{"hash":"989809335860820584","title":"Hormone and Xenobiotic Metabolism","description":"The top GO terms cluster around metabolic processing of hormones and foreign compounds: estrogen catabolic process, regulation of angiotensin levels in blood, catecholamine and bile acid metabolism, sulfate assimilation, and xenobiotic metabolic processes. These together point to detoxification and hormone homeostasis mechanisms as the core theme, despite a few obsolete terms that reflect legacy annotations.","confidence":"High","size":18,"edges":24,"triangles":9,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":11},{"id":"GO:0030206","count":11},{"id":"GO:0006711","count":9},{"id":"GO:0002002","count":9},{"id":"GO:0006584","count":9}]},{"hash":"984660642707406033","title":"Sterol and sphingolipid biosynthesis","description":"This cluster is dominated by lipid-related processes: ergosterol biosynthetic process, ether lipid metabolic process, and sphingolipid metabolism (mannosyl-inositol phosphorylceramide). These point to a membrane lipid biosynthesis module. A few terms (sebaceous gland differentiation, CNS myelin maintenance, B cell chemotaxis) are less consistent with lipids and may reflect cross-species annotation noise, but the strongest signal aligns with sterol and sphingolipid pathways. ","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001949","count":4},{"id":"GO:0006675","count":4},{"id":"GO:0032286","count":4},{"id":"GO:0070542","count":3},{"id":"GO:0042128","count":3}]},{"hash":"1200429796461556212","title":"Autonomic nervous system and glandular secretion","description":"The terms cluster around neural/autonomic control of secretory processes and gland development: saliva secretion, catecholamine-regulated heart rate and vasoconstriction, enteric nervous system development, and transepithelial chloride transport in secretory epithelia, with supporting hints from gland development and neural signaling. This suggests a neuroendocrine, autonomic-gland axis theme for the group.","confidence":"High","size":18,"edges":106,"triangles":291,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":16},{"id":"GO:0060658","count":15},{"id":"GO:0035106","count":15},{"id":"GO:0035815","count":15},{"id":"GO:0001994","count":15}]},{"hash":"955210822641270018","title":"Mammalian reproductive tissue development and signaling","description":"This cluster is dominated by terms tied to development and differentiation in reproductive-related tissues: Leydig cell differentiation and mammary gland alveolus development, plus regulation of oocyte maturation. Supporting signals include DNA-templated transcription and GPCR-mediated cAMP/cGMP pathways, indicating coordinated transcriptional programs and signaling. Some terms (nitric oxide defense and hypoxia detection) appear less directly connected and may reflect broader cellular responses or annotation noise.","confidence":"Medium","size":18,"edges":40,"triangles":28,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0033327","count":9},{"id":"GO:0060749","count":9},{"id":"GO:1900194","count":8},{"id":"GO:0006182","count":8}]},{"hash":"2281550883239245989","title":"Inflammation and coagulation signaling","description":"The top GO terms center on innate immune/inflammatory responses (complement activation, IL-1 response, apoptotic cell recognition) and hemostasis (blood coagulation, platelet aggregation, platelet regulation), along with associated signaling (RTK activation). Taken together, they suggest a cohesive module coordinating inflammation with coagulation and platelet activity, with a minor cross-reference to tissue repair/regeneration processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":13},{"id":"GO:0071347","count":13},{"id":"GO:0072378","count":13},{"id":"GO:0071493","count":13},{"id":"GO:0014814","count":13}]},{"hash":"838218427098965332","title":"Glycosylated plant surface proteins and AGP development","description":"This cluster is dominated by glycosylation-associated processes (arab\u00ednogalactan proteins, poly-N-acetyllactosamine biosynthesis, O-linked glycosylation) and surface-related developmental functions (root hair development, seed coat mucilage formation, cell adhesion/polarity), suggesting a cohesive theme of glycoprotein-mediated cell surfaces guiding plant development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030311","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0010405","count":3},{"id":"GO:0048354","count":3},{"id":"GO:0080147","count":3}]},{"hash":"957393860901159852","title":"Unknown","description":"The listed GO terms are scattered across apoptosis, NF-kappaB signaling, immune/inflammatory responses, xenobiotic response, and various biosynthetic/nutrient processes, with no clear shared pathway tying the proteins together; the graph has no edges, indicating a lack of cohesive functional coupling. Therefore, there isn\u2019t a consistent theme to name; label Unknown.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006919","count":2},{"id":"GO:1990000","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0010881","count":2},{"id":"GO:0035690","count":2}]},{"hash":"311497720525886634","title":"Mitotic Regulation and Kinase Signaling","description":"The top GO terms point to mitotic cell cycle and mitotic spindle assembly, plus multiple phosphorylation-related processes (positive regulation of kinases, phosphoprotein phosphatase activity, protein autophosphorylation). This suggests a coherent theme around cell division control and signaling via phosphorylation, despite a few broad or outlier terms. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032516","count":6},{"id":"GO:0043588","count":6},{"id":"GO:0007613","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0071456","count":6}]},{"hash":"250640715071080083","title":"Neural development and neuroinflammatory signaling","description":"This cluster is dominated by GO terms related to axon guidance, extension, fasciculation, and synapse assembly (neural development), with additional terms pointing to inflammatory/neuroimmune processes and stress hormone responses, suggesting proteins coordinating neural connectivity with inflammatory signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019800","count":11},{"id":"GO:0051965","count":11},{"id":"GO:0006954","count":11},{"id":"GO:0007413","count":11},{"id":"GO:0021972","count":11}]},{"hash":"1913434426367126657","title":"Innate antiviral defense and ubiquitin-mediated regulation","description":"The cluster is enriched for innate immune response and defense against virus, along with ubiquitin-proteasome pathways (K48-linked ubiquitination, SCF-dependent degradation) and interferon signaling, suggesting a cohesive role in antiviral defense and protein turnover. Some terms like cilium assembly and development are present but appear less central to the main theme; overall, immunity and ubiquitin-regulated processes dominate. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0060271","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0048899","count":2},{"id":"GO:0032911","count":2}]},{"hash":"433196894986119937","title":"GPCR Signaling and Hormonal Regulation","description":"This cluster centers on GPCR-mediated signaling pathways, including adenylate cyclase-activating and PLC-activating routes (cAMP and IP3/DAG), with downstream effects on growth hormone secretion and blood pressure regulation. The co-occurrence of Rho signaling and inositol phosphate biosynthesis supports a shared theme of GPCR-driven second messenger cascades coordinating vascular tone and endocrine responses. The electron transport chain term appears tangential. Confidence: Medium.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":8},{"id":"GO:0010579","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0035025","count":7},{"id":"GO:0048469","count":5}]},{"hash":"880340729143319610","title":"Glycan and proteoglycan/ganglioside biosynthesis","description":"The top GO terms cluster around biosynthesis of glycans and glycoconjugates: keratan sulfate and heparan sulfate proteoglycan biosynthesis, glycosylceramide/ganglioside biosynthesis, oligosaccharide metabolism, and N-linked glycosylation. Some pollen-related terms appear but do not overturn the dominant theme of glycoconjugate and glycosphingolipid formation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018146","count":5},{"id":"GO:0030210","count":4},{"id":"GO:0006054","count":3},{"id":"GO:0009846","count":3},{"id":"GO:0018279","count":3}]},{"hash":"1824421206156158386","title":"Axon guidance and synapse formation","description":"This cluster is dominated by GO terms tied to neural connectivity, including positive regulation of synapse assembly, the Roundabout signaling pathway (ROBO), and both homophilic and heterophilic cell-cell adhesion, plus paranodal junction assembly. These collectively point to roles in axon guidance, neural cell adhesion, and synapse formation, with some broader morphogenesis signals likely due to pleiotropy.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0033138","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0043552","count":3},{"id":"GO:2000811","count":2}]},{"hash":"577342566163558939","title":"Genome maintenance and chromatin regulation","description":"This cluster\u2019s top GO terms cluster around nuclear DNA processes: regulation of rRNA processing, telomere maintenance, cell cycle DNA replication, chromatin localization, and DNA repair/damage response. Together these suggest a shared theme of genome maintenance and chromatin dynamics, despite a few outliers (heme transport, insulin response, pro-B cell differentiation) that may reflect multifunctional proteins or annotation noise. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000232","count":3},{"id":"GO:0015886","count":2},{"id":"GO:0006288","count":2},{"id":"GO:0010833","count":2},{"id":"GO:0044786","count":2}]},{"hash":"98278298412394129","title":"Ubiquitin-Dependent Proteolysis and Inflammatory Signaling","description":"The cluster's top GO terms are dominated by ubiquitination processes (ubiquitin-dependent proteolysis, autoubiquitination, K6- and K63-linked ubiquitination) and histone turnover, with notable enrichment for regulation of NF-\u03baB, JNK, and TNF signaling. This points to a coherent group of proteins involved in ubiquitin-mediated proteostasis that also modulates inflammatory signaling pathways.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0051865","count":14},{"id":"GO:0085020","count":13},{"id":"GO:0036205","count":13},{"id":"GO:1903265","count":13}]},{"hash":"802748632244060879","title":"Ubiquitin-Dependent Immune Signaling","description":"The top GO terms cluster around ubiquitin-mediated regulation (ubiquitin-dependent proteolysis; K6- and K63-linked ubiquitination) together with immune responses (innate antiviral defense, defense response to virus, NF-kappaB signaling). While some terms touch chromatin remodeling, the shared theme is ubiquitin-driven modulation of immune signaling pathways, including antiviral responses. This suggests the proteins form a module underlying ubiquitin-dependent immune regulation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0051607","count":14},{"id":"GO:0045087","count":14},{"id":"GO:0009048","count":13},{"id":"GO:0033209","count":13}]},{"hash":"27686293174525327","title":"Cardiac signaling and remodeling","description":"This cluster centers on heart-related functions such as SA node action potential regulation, membrane depolarization in cardiac muscle, and mechanotransduction from muscle stretch, paired with extracellular matrix remodeling (collagen fibril organization) and angiogenesis, plus lipid metabolism (cholesterol and glycerophospholipid turnover). Together these suggest a cohesive theme of cardiac electrophysiology intertwined with structural remodeling and metabolic support, though a few terms are more general or less heart-specific. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":4},{"id":"GO:0071901","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0071347","count":3},{"id":"GO:0045766","count":3}]},{"hash":"751991105395286654","title":"Cytoskeleton remodeling and vesicle trafficking","description":"The top GO terms span mitotic spindle assembly, lamellipodium and stress fiber regulation, cell polarity and shape, melanosome transport, dendrite development, multivesicular body sorting, and regulation of synaptic vesicle exocytosis. Together these indicate a common theme of cytoskeletal dynamics coupled with membrane trafficking and transport, underlying cell shape changes, polarity, and intracellular vesicle movement. The absence of edges suggests the proteins may operate in related pathways rather than a single tight complex, but they converge on this shared functional axis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0000060","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0010592","count":2},{"id":"GO:0071963","count":2}]},{"hash":"1298537251345441030","title":"Corticospinal axon guidance and synapse assembly","description":"Based on the top terms, the cluster centers on neuronal development and connectivity, especially corticospinal axon guidance, axon extension, and synapse assembly. While inflammatory and cortisol-related terms appear, the dominant theme is neural connectivity formation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071372","count":9},{"id":"GO:0048846","count":9},{"id":"GO:0019800","count":8},{"id":"GO:0051965","count":8},{"id":"GO:0006954","count":8}]},{"hash":"210895719078143871","title":"Nervous system development and myelination","description":"Based on the top GO terms, the cluster centers on neural development and myelination: multiple terms point to nervous system development, peripheral nervous system development, and myelination, with Hedgehog/Smoothened signaling (GO:0007224) linked to neural patterning and oligodendrocyte maturation. While there are a few immune-related terms, they are less prominent, so the dominant theme is nervous system formation and myelin biology.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007224","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0045663","count":4},{"id":"GO:0007422","count":4}]},{"hash":"503323048366626462","title":"Axon guidance and synapse formation","description":"Dominant GO terms are about neuronal connectivity\u2014axon extension and guidance, and synapse assembly\u2014with a note of mechanosensitive signaling. Inflammatory response and negative regulation of angiogenesis appear but seem secondary to the core neuronal development/wiring theme, suggesting a neurovascular context. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019800","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0006954","count":5},{"id":"GO:0071372","count":5},{"id":"GO:0016525","count":5}]},{"hash":"2067709425021380078","title":"Cytoskeleton and vesicle transport regulation","description":"The top GO terms cluster around cytoskeletal organization (neurofilament cytoskeleton) and various transport pathways (endocytic recycling, lysosomal transport, dense core granule transport), plus movement-related processes (locomotion, musculoskeletal movement). This points to a cohesive theme of intracellular transport governed by the cytoskeleton, influencing cell movement and tissue organization, with a note that extrinsic apoptotic signaling terms are less central to this core.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0001675","count":1},{"id":"GO:0032456","count":1},{"id":"GO:0050881","count":1}]},{"hash":"486847391123736580","title":"RNA capping and methylation machinery","description":"The top GO terms are dominated by RNA processing\u2014specifically 7-methylguanosine mRNA capping and RNA methylation/methylation\u2014suggesting the cluster centers on post-transcriptional RNA modification and processing. While vesicle transport between ER and Golgi and apoptotic terms appear, they are less prominent, so the core theme most consistent with the data is RNA capping/methylation machinery, with possible secondary roles in vesicle trafficking and cell regulation.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0034349","count":2}]},{"hash":"630661879855942994","title":"Growth signaling and ribosome biogenesis","description":"The terms point to growth-regulating pathways (TORC1 signaling, TGF-beta response) and increased protein synthesis via ribosome biogenesis, alongside developmental programs (brain development, multicellular development). DNA damage response terms appear peripheral, not defining the cluster. Thus the core theme is growth signaling linked to protein production and development.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:0000724","count":3},{"id":"GO:0072432","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0038202","count":3}]},{"hash":"219710501161327755","title":"Neuronal signaling and synaptic transmission","description":"The cluster centers on neural communication and excitability, with GO terms for sensory perception (sound), visual pathway development (LGN), GABA receptor clustering, acetylcholine signaling, sodium transport, and membrane depolarization, all pointing to synaptic transmission and neuronal signaling. A couple of terms appear as annotation noise (obsolete viral release, baroreceptor-related heart rate), but the predominant pattern is neural signaling rather than metabolism or structural components.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0051899","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0044791","count":2},{"id":"GO:0090090","count":2}]},{"hash":"1883701611144803336","title":"Hydroxyproline-rich glycoprotein glycosylation and AGP biosynthesis","description":"The top GO terms point to arabinogalactan protein metabolism, hydroxyproline O-linked glycosylation, and related seed coat/mucilage processes, along with root hair development and cell polarity in plant tissues. This pattern strongly suggests a cohesive theme of plant extracellular matrix glycoprotein production, especially HRGPs and AGPs involved in cell wall dynamics and development. Some terms appear more divergent (e.g., infection structure formation, insect visual primordium), likely cross-annotation noise rather than core functions of the cluster. Therefore, a label focusing on HRGP/AGP glycosylation and biosynthesis is appropriate.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0030311","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0010405","count":3},{"id":"GO:0048354","count":3}]},{"hash":"2203587433122447582","title":"Negative Regulation of Extrinsic Apoptosis","description":"The cluster\u2019s top GO terms are dominated by extrinsic apoptotic signaling and its negative regulation (including death receptor\u2013mediated pathways and signaling in the absence of ligand), with additional alignment to B cell apoptosis and immune-related tissues like the spleen. This suggests proteins in the cluster collectively dampen or modulate extrinsic apoptosis rather than promoting it, despite occasional unrelated terms present.","confidence":"Medium","size":17,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006808","count":3},{"id":"GO:0097296","count":3},{"id":"GO:0097192","count":3},{"id":"GO:0048536","count":3},{"id":"GO:0060546","count":3}]},{"hash":"1566763633608583453","title":"Ubiquitin-Dependent Proteolysis and ERAD","description":"This cluster is dominated by GO terms for ubiquitin-mediated protein degradation, including SCF-dependent proteasomal degradation, autoubiquitination, multiple ubiquitin linkages (K11, K6, K48), and the ERAD pathway. The core theme is tagging substrates for destruction by the proteasome, with auxiliary hints at roles in cell-cycle regulation and DNA repair. Overall, the proteins appear to function in ubiquitin-dependent proteolysis and associated quality-control pathways.","confidence":"High","size":17,"edges":68,"triangles":135,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":7},{"id":"GO:0051865","count":7},{"id":"GO:0042787","count":6},{"id":"GO:0070979","count":6},{"id":"GO:0016032","count":6}]},{"hash":"590161501942792482","title":"ER protein folding and gene expression regulation","description":"The top GO terms cluster around protein folding in the endoplasmic reticulum and general protein folding, with contributors to redox homeostasis and regulation of transcription and post-transcriptional gene expression. Some terms touch on bone development and interferon signaling, but the dominant theme appears to be ER proteostasis intertwined with transcriptional/post-transcriptional control, suggesting a cellular-stress\u2013response module affecting protein folding and gene regulation.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0006457","count":1}]},{"hash":"1519062564281523507","title":"Neuroendocrine Secretory Signaling","description":"The cluster shows a coherent signal around secretory and signaling functions: dense core granule exocytosis, insulin secretion in response to glucose, and GPCR-PLC\u2013mediated signaling, which are hallmark processes in neuroendocrine and neuronal hormone release. while other terms like brain and gonad development or angiogenesis regulation are broader contextual associations, the strongest shared thread is secretory signaling and hormone release in neuroendocrine contexts.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0007200","count":2},{"id":"GO:0008584","count":2}]},{"hash":"2135086491410923372","title":"Oxidative Stress Response and Ubiquitin-Mediated Regulation","description":"The cluster is enriched for cellular response to hydrogen peroxide and ubiquitin-related processes (K11-linked ubiquitination), with an additional hint of mitotic cell cycle regulation; together these terms point to a theme of stress-activated protein turnover and regulation, albeit with some outliers like photoreceptor segment localization and prostate development terms. This suggests a cohesive but broad role in stress response and protein quality control rather than a single tightly defined pathway.","confidence":"Medium","size":17,"edges":13,"triangles":0,"max_degree":13,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0070301","count":4},{"id":"GO:0061087","count":4},{"id":"GO:0070979","count":4},{"id":"GO:1903546","count":4},{"id":"GO:0030850","count":4}]},{"hash":"742266545059714237","title":"Glycosylation and glycosphingolipid biosynthesis","description":"This cluster is enriched for GO terms related to N-glycan processing and N-linked glycosylation, as well as glycosphingolipid metabolism (glycosylceramide and ganglioside biosynthesis). These terms together point to a shared theme of glycosylation pathways affecting both proteins and membrane lipids, rather than a single organismal process; the pollen/olfactory terms may reflect broader developmental roles of these pathways in different tissues.","confidence":"Medium","size":17,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006491","count":4},{"id":"GO:0006054","count":3},{"id":"GO:0009846","count":3},{"id":"GO:0018279","count":3},{"id":"GO:0021628","count":3}]},{"hash":"938139326161908306","title":"Oxidative stress response and detoxification","description":"This cluster is enriched for GO terms tied to detoxification and oxidative stress, including cellular oxidant detoxification, glutathione metabolism, toxin catabolic processes, and responses to metal and starvation. The presence of nucleotide-excision repair and prostaglandin biosynthesis suggests broader stress signaling and damage-response roles. Overall, the proteins likely participate in protecting cells from oxidative damage through detox pathways and related metabolic adjustments.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":14},{"id":"GO:0042594","count":8},{"id":"GO:0009407","count":8},{"id":"GO:0006289","count":8},{"id":"GO:0001516","count":8}]},{"hash":"2012074848982337941","title":"Post-transcriptional gene regulation","description":"Most top GO terms describe RNA-mediated gene silencing (ncRNA/miRNA) and post-transcriptional processing, including translation reinitiation, translation preinitiation complex formation, mRNA splicing regulation, mRNA modification, export, and stability in response to stress. This suggests the proteins form a module coordinating RNA silencing with mRNA maturation and translation control.","confidence":"High","size":17,"edges":90,"triangles":251,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":6},{"id":"GO:0035278","count":6},{"id":"GO:0002188","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0016556","count":5}]},{"hash":"1461612323398800911","title":"Synaptic plasticity and actin remodeling","description":"This cluster is dominated by GO terms tied to synaptic structural plasticity, actin filament polymerization, ephrin receptor signaling, Wnt signaling, and endocytosis, all of which are central to activity-dependent synapse remodeling and cytoskeletal dynamics in neurons (with hippocampus development and cell polarity terms supporting a neural context). Although some terms (like T cell signaling) hint at broader signaling networks, the strongest signals point to neural synapse regulation and actin remodeling as the core theme.","confidence":"Medium","size":17,"edges":68,"triangles":96,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051835","count":6},{"id":"GO:0030838","count":6},{"id":"GO:0048013","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0050852","count":6}]},{"hash":"930053371963788677","title":"Innate immune signaling with Ca2+/ROS dynamics","description":"Based on the dominant GO terms, the proteins cluster around innate immune/inflammatory signaling, with supporting roles in calcium signaling and reactive oxygen species production. Terms like inflammatory response, innate immune response, calcium ion transmembrane transport, detection of calcium ion, hydrogen peroxide biosynthetic process, GPCR signaling pathway, and activation of adenylate cyclase activity together point to a signaling module that integrates calcium and GPCR pathways with immune responses. The presence of visual perception is likely an annotation artifact. Overall, the label captures a signaling-focused immune cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007601","count":2},{"id":"GO:0005513","count":2},{"id":"GO:0050665","count":2}]},{"hash":"1633945957161994209","title":"Glycolysis-TCA Energy Metabolism","description":"This cluster is dominated by GO terms tied to central carbon metabolism and energy production: glycolytic process, glucose metabolic process, TCA cycle, and regulation of pyruvate decarboxylation to acetyl-CoA, plus acetyl-CoA biosynthesis and branched-chain amino acid catabolism. These recurring metabolic themes suggest the proteins share a core role in energy production across glycolysis and mitochondrial respiration, with a few older/obsolete terms and a single outlier (neuronal migration) that do not override the central theme.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0009228","count":1},{"id":"GO:0010510","count":1},{"id":"GO:0061732","count":1},{"id":"GO:0006099","count":1}]},{"hash":"790543529376055196","title":"Nitrogen metabolism and nutrient signaling","description":"The top GO terms cluster around nitrogen-related processes (nitrogen fixation, nitrogen starvation response, nitrogen catabolite repression) and general nutrient sensing (response to glucose), with supporting mentions of protein regulation and host-interaction. This suggests the cluster represents proteins involved in nutrient sensing and nitrogen metabolism, potentially in a host-associated or symbiotic microbial context, rather than a single, cohesive eukaryotic pathway.","confidence":"Medium","size":17,"edges":49,"triangles":13,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0090295","count":7},{"id":"GO:0009399","count":7},{"id":"GO:0009405","count":7},{"id":"GO:0051968","count":7},{"id":"GO:0051260","count":7}]},{"hash":"800869981356921947","title":"Lipid biosynthesis and adipogenesis","description":"The top GO terms point to fatty acid and sphingolipid biosynthesis (monounsaturated fatty acids, sphinganine/sphingosine pathways) and white fat cell differentiation, with related lipid processing like cholesterol esterification. Although some terms are unrelated or obsolete, the dominant theme is lipid metabolism and adipocyte development, with insect-specific lipid gland development also aligning with lipid synthesis. ","confidence":"High","size":17,"edges":86,"triangles":215,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":8},{"id":"GO:1903966","count":7},{"id":"GO:0006667","count":7},{"id":"GO:0010873","count":7},{"id":"GO:1903699","count":7}]},{"hash":"1851330594231742816","title":"Neuronal development and synaptic organization","description":"I named it this because the cluster is enriched for nervous system development and synaptic-related processes, including retina development, neuroblast differentiation, postsynaptic membrane assembly, synaptic vesicle clustering, acetylcholine catabolism in the synaptic cleft, and receptor internalization. These themes point to neural differentiation and the formation and modulation of synapses, with a secondary but less dominant signal for osteoblast development and xenobiotic response. Confidence: High","confidence":"","size":17,"edges":134,"triangles":650,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0002087","count":10},{"id":"GO:0060041","count":10},{"id":"GO:0002076","count":10},{"id":"GO:0042493","count":9},{"id":"GO:0097104","count":8}]},{"hash":"2215232145209458118","title":"Lipid metabolism and energy catabolism","description":"This cluster is dominated by GO terms tied to energy-yielding metabolic pathways, including fatty acid beta-oxidation (and medium-chain FA catabolism), leucine (an amino acid) catabolism, and steroid biosynthesis, along with a response to starvation. These collectively suggest a theme of lipid- and amino-acid\u2013driven energy production and metabolic adaptation, despite a couple of development-related terms that reflect tissues where such metabolism is critical (liver, cardiac muscle). ","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006552","count":3},{"id":"GO:0009820","count":2},{"id":"GO:0042594","count":2},{"id":"GO:0006694","count":2}]},{"hash":"1440256935019109477","title":"Neural Autonomic Regulation of Cardiovascular and Renal Function","description":"These proteins point to neural and autonomic control of visceral physiology: catecholamine-driven cardiovascular effects (vasoconstriction and heart rate modulation), renal sodium handling, epithelial ion transport, and related signaling pathways (IP3 signaling, chemokine signaling). Although a few terms are developmentally oriented or unexpected, the dominant pattern centers on neural regulation of heart, blood pressure, kidney function, and associated responses. This suggests a coherent theme of neuroautonomic control of cardio-renal physiology.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060658","count":17},{"id":"GO:0035106","count":17},{"id":"GO:0035815","count":17},{"id":"GO:0001994","count":17},{"id":"GO:0001996","count":17}]},{"hash":"719891887474034585","title":"Multi-substrate Membrane Transporters","description":"These proteins are strongly linked by GO terms describing transmembrane transport of a wide range of substrates\u2014vitamins, xenobiotics, sugars, ions (sodium, phosphate), and other small molecules\u2014plus a vesicular transporter function for neurotransmitter loading. The broad but cohesive theme indicates a cluster of membrane transporter proteins with diverse substrate specificities, including both general transmembrane transport and vesicular transport activities. Confidence: High","confidence":"","size":17,"edges":49,"triangles":35,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":16},{"id":"GO:0042891","count":16},{"id":"GO:0006855","count":16},{"id":"GO:0098700","count":15},{"id":"GO:0015739","count":15}]},{"hash":"268686463112535153","title":"Immune response and coagulation pathways","description":"GO terms indicate adaptive immune response, lectin pathway complement activation, platelet function and blood coagulation, inflammatory signaling (IL-1), and recognition of apoptotic cells, pointing to a module that integrates immunity, inflammation, and hemostasis. The presence of coagulation, platelet-related terms, and apoptotic cell recognition alongside immune signaling supports labeling the cluster as immune-coagulation related, with some stress-response terms like UV-B reflection. Confidence in this label is High.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":8},{"id":"GO:0002250","count":8},{"id":"GO:0001867","count":7},{"id":"GO:0071347","count":7},{"id":"GO:0072378","count":7}]},{"hash":"484247359559883128","title":"Immune-vascular remodeling and neural regeneration","description":"These terms cluster around immune activation (complement lectin pathway, adaptive immune response, IL-1 signaling), vascular remodeling (endothelial migration, angiogenesis) and coagulation, with MAPK/ERK signaling. Additional terms point to stress responses (UV-B) and neural repair at the neuromuscular junction, suggesting a module where immune responses drive vascular changes and tissue regeneration. Therefore, an integrated immune-vascular remodeling with regenerative signaling best captures the shared theme.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":14},{"id":"GO:0043536","count":10},{"id":"GO:0002250","count":10},{"id":"GO:0051968","count":10},{"id":"GO:0001525","count":10}]},{"hash":"1058153325595157364","title":"Neural-immune calcium signaling","description":"This cluster includes neural-related terms (fiber-type transition, glutamatergic synaptic transmission, Schwann cell development) alongside immune functions (adaptive immune response, lectin pathway complement activation) and calcium-dependent signaling (calcineurin-NFAT, calcium ion detection). The overlap suggests proteins involved in cross-talk between the nervous and immune systems mediated by calcium signaling, rather than a single, narrow pathway. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0014883","count":4},{"id":"GO:0002250","count":3},{"id":"GO:0051968","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0001867","count":3}]},{"hash":"1712745539502207582","title":"Developmental Signaling and Apoptosis","description":"The proteins appear linked by signals controlling cell fate: apoptosis, insulin/MAPK/Notch signaling, angiogenesis and neuron development, plus DNA repair. This suggests a cohesive theme of signaling pathways guiding development and cell death rather than a single, isolated function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0046626","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007258","count":2},{"id":"GO:2000251","count":2}]},{"hash":"1410748033517818313","title":"Hematopoietic and Immune Cell Signaling","description":"The cluster centers on hematopoietic development and immune signaling: KIT pathway activity, megakaryocyte development, B and T cell receptor signaling, production of cytokines like IL-3 and GM-CSF, and innate immune responses, with angiogenesis often linked to the hematopoietic niche. This coherent theme supports labeling as hematopoietic/immune signaling. ","confidence":"High","size":17,"edges":26,"triangles":10,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010863","count":10},{"id":"GO:0001525","count":10},{"id":"GO:0043552","count":10},{"id":"GO:0038109","count":10},{"id":"GO:0045401","count":9}]},{"hash":"115064468142688341","title":"Diverse Stress-Response Signaling","description":"The top terms include calcium ion response, cardiac membrane potential and action potential regulation, and stress-related processes (temperature stimulus, osmotic stress), alongside cortisol biosynthesis, CO2 detection, and T cell receptor signaling. This points to a broad set of signaling and stress-response functions rather than a single cohesive pathway, so the label aims to reflect general signal transduction under stress, though the coherence is limited.","confidence":"Low","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051592","count":4},{"id":"GO:0060372","count":3},{"id":"GO:0034651","count":3},{"id":"GO:0086002","count":3},{"id":"GO:0060371","count":3}]},{"hash":"171525734691675245","title":"CNS axon guidance and synapse formation","description":"The top GO terms point to neural development, with clear emphasis on axon guidance (corticospinal neuron axon guidance, axon extension), corpus callosum development, and synapse assembly, indicating a cluster of proteins coordinating neural connectivity and synaptic formation in the CNS. Some terms about inflammation or mechanical response appear ancillary and do not outweigh the CNS wiring theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":9},{"id":"GO:0019800","count":8},{"id":"GO:0006954","count":8},{"id":"GO:0022038","count":8},{"id":"GO:0016525","count":8}]},{"hash":"78417392872031381","title":"TLR/MyD88-Driven Inflammatory Signaling","description":"The GO terms cluster around innate immune activation in response to lipopolysaccharide, including cellular response to LPS, inflammatory response, and MyD88-dependent TLR signaling. Additional terms like ubiquitination and transcriptional regulation suggest downstream signaling modulation, while some remaining terms (NFAT signaling, cardiac depolarization) may reflect broader signaling cross-talk but are less central to the core theme. Overall, the dominant pattern is LPS-triggered inflammatory signaling via TLR/MyD88 pathways.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0002755","count":2}]},{"hash":"2110918800323368835","title":"RNA Regulation in Neural Development","description":"The cluster centers on post-transcriptional regulation, highlighted by terms for P-body assembly, miRNA-mediated silencing, and cytoplasmic mRNA processing, with neural-development-related terms like photoreceptor development and olfactory learning suggesting a broader role in neural development.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060965","count":4},{"id":"GO:0033962","count":4},{"id":"GO:0042051","count":4},{"id":"GO:0002091","count":4},{"id":"GO:0009994","count":4}]},{"hash":"1913376788370051062","title":"Rho\u2011driven cytoskeleton remodeling and adhesion","description":"The top GO terms cluster around Rho protein signal transduction regulation, lamellipodium and microspike/actin cytoskeleton organization, and substrate adhesion\u2013dependent spreading, all pointing to cytoskeletal dynamics and cell\u2013matrix adhesion. Additional terms like thrombin receptor signaling and receptor-mediated endocytosis fit membrane signaling/trafficking that often accompany cytoskeletal changes. A few terms (e.g., sodium transport, IL-2 production) are less directly tied, suggesting a broader set of functions represented in this group. Overall, the common theme appears to be Rho\u2011regulated cytoskeleton remodeling and adhesion processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0034446","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0030032","count":3},{"id":"GO:1900042","count":3}]},{"hash":"402037526487521393","title":"RNA and protein methyltransferases","description":"This cluster\u2019s top GO terms are dominated by methylation activities: RNA guanine-N7 methylation, rRNA/tRNA methylation, N-terminal peptidyl-alanine trimethylation, and histone methylation. Some terms also touch methylation steps in biosynthetic pathways (antibiotic, biotin, menaquinone, cobalamin biosynthesis), which commonly involve methyltransferases. The overall pattern suggests these proteins are enriched for methyltransferase activities targeting RNA and proteins, with incidental links to biosynthetic pathway methylation; the nodulation term appears as noise but does not outweigh the methylation theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":6},{"id":"GO:0017000","count":6},{"id":"GO:0009102","count":6},{"id":"GO:0009234","count":5},{"id":"GO:0009236","count":5}]},{"hash":"1765795457942184255","title":"Plant development and cell wall metabolism","description":"This cluster combines GO terms for plant developmental processes (leaf morphogenesis, positive regulation of flower development, root hair cell development) with carbohydrate and cell wall-related metabolism (carbohydrate metabolic process, glycoside and glycosylceramide catabolic processes, cell wall organization, rhamnogalacturonan II biosynthesis). The overlap of growth, tissue patterning, and cell wall remodeling points to a cohesive role in plant growth and morphogenesis. Confidence: High","confidence":"","size":17,"edges":51,"triangles":52,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":6},{"id":"GO:0016139","count":5},{"id":"GO:0009965","count":5},{"id":"GO:0009911","count":5},{"id":"GO:0045019","count":5}]},{"hash":"707992950898784365","title":"Neural Development and Axon Guidance","description":"Based on the top GO terms, the proteins are enriched for neuron projection development, nervous system development, and axon guidance (axonal fasciculation and ROBO pathway). While some terms touch on skeletal/muscle development or obsolete PI3K/NF-kB activities, the dominant signal is neural development and axon pathfinding, justifying the name.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031175","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1892860699075810474","title":"Neural, muscular, and reproductive development","description":"The top GO terms cluster around developmental processes across multiple tissues: brain and hippocampus development, spermatid development, myoblast fusion, and related regulation of neural vesicle exocytosis. While a couple terms touch on viral processes, the dominant signal is multisystem development with a neural-muscular-reproductive emphasis.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":2},{"id":"GO:0007520","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0033138","count":2}]},{"hash":"731811069514381060","title":"Cardiac Ion Transport and Heart Regulation","description":"The cluster\u2019s top GO terms center on regulation of sodium ion transport, regulation of heart rate by cardiac conduction, and regulation of ventricular muscle cell membrane repolarization, with an angiotensin-activated signaling pathway linked to heart processes. While there are a few non-cardiac terms (e.g., T cell costimulation, TGF-beta signaling, ubiquitination, hyperoxia response), the strongest and plurality of signals point to cardiac ion signaling and electrophysiology, justifying a cardiac-focused label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000649","count":2},{"id":"GO:0086091","count":2},{"id":"GO:0060307","count":2},{"id":"GO:0031295","count":2},{"id":"GO:0086098","count":1}]},{"hash":"385675359255104532","title":"Axon guidance and synapse assembly","description":"The proteins in this cluster are enriched for neural development processes: axon guidance and fasciculation, regulation of synapse assembly, and myelination, along with cell adhesion and embryonic morphogenesis cues. The SHH pathway (smoothened signaling) and myogenic differentiation terms also align with broader developmental roles that often accompany neural maturation. While one term about symbiont entry into host cells stands out as an outlier or annotation quirk, the dominant theme is neural development and synaptic organization, justifying a label focused on axon guidance and synapse assembly.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046718","count":7},{"id":"GO:0051963","count":6},{"id":"GO:0042552","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0007413","count":6}]},{"hash":"1547067095685712345","title":"Ubiquitin-Dependent Proteolysis and TNF/NF-\u03baB Signaling","description":"This cluster is dominated by GO terms for ubiquitin-mediated proteolysis, ERAD, and autoubiquitination, with strong ties to TNF signaling, NF-\u03baB activation, JNK regulation, and innate immune responses. The recurring theme is ubiquitin-dependent protein turnover that modulates inflammatory signaling pathways, suggesting a functional module around protein degradation coordinating immune responses. Some terms (vitamin D response, X chromosome dosage compensation) are less aligned but do not override the main theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0033280","count":14},{"id":"GO:0051865","count":13},{"id":"GO:0030433","count":13},{"id":"GO:0009048","count":12}]},{"hash":"1064228252127142973","title":"Skeletal and muscular development with neural and cardiac features","description":"The cluster\u2019s top GO terms cover skeletal system development, muscle cell development, and chondrocyte development, plus neural-related terms (anterior/posterior axon guidance, synapse assembly) and heart regulation (ventricular repolarization, heart rate). This mix points to developmental processes spanning multiple tissues\u2014bone/muscle/cartilage, nervous system, and heart\u2014rather than a single, cohesive pathway. The label reflects an integrated view of developmental biology across these tissues, with some immune-related terms as peripheral associations.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0033564","count":2},{"id":"GO:0001798","count":2}]},{"hash":"131513852558653689","title":"Unknown","description":"The top GO terms are diverse and span distinct biological contexts (placental morphogenesis, smooth muscle proliferation, inflammatory cytokine regulation, fatty acid oxidation, seed maturation, peripheral nerve regeneration, PDGF signaling, oxidative stress response, focal adhesion, MCP-1 production). With no edges or connectivity, there is no coherent shared function linking the proteins, so a specific label cannot be assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060672","count":2},{"id":"GO:0048662","count":1},{"id":"GO:1900016","count":1},{"id":"GO:0046322","count":1},{"id":"GO:0010431","count":1}]},{"hash":"1022685241924976816","title":"Glycinergic Synapse Regulation and Neural Development","description":"Most prominent GO terms point to glycinergic neurotransmission (regulation and transmission, glycine import) and related neural signaling, with accompanying terms on glial growth and brain region development (thalamus, adenohypophysis). The cluster seems centered on inhibitory glycine signaling in neural contexts, with supportive glial involvement and generic neurotransmitter regulation. This combination supports a label focusing on glycinergic synapse function within neural development. ","confidence":"High","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060092","count":4},{"id":"GO:0042066","count":4},{"id":"GO:0036233","count":4},{"id":"GO:0021984","count":4},{"id":"GO:0015820","count":4}]},{"hash":"682420010897297186","title":"Interferon-responsive vesicle trafficking cluster","description":"The proteins show enrichment for interferon-alpha/beta response and vesicle transport processes (endosome to plasma membrane, synaptic vesicle clustering), suggesting a theme of immune signaling linked to intracellular trafficking. Some terms like glucose import with insulin stimulus and bone-related processes appear less connected to this core pattern, likely representing broader or contextual roles. ","confidence":"Medium","size":16,"edges":112,"triangles":458,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":6},{"id":"GO:0035455","count":6},{"id":"GO:0050884","count":6},{"id":"GO:0097091","count":6},{"id":"GO:0046597","count":6}]},{"hash":"2038551473628825278","title":"Neuronal development and synapse formation","description":"This cluster centers on terms related to neural development and synapse biology (positive regulation of synapse assembly, axonal fasciculation, pyramidal neuron differentiation, myelination), suggesting the proteins are involved in neuron development, connectivity, and possibly synaptic maturation. While a few terms touch on broader developmental processes like heart development or angiogenesis, the strongest and most representative signals are neural-specific, supporting a focus on neuronal differentiation and synaptogenesis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0032474","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0007507","count":4}]},{"hash":"946634406768516741","title":"mRNA processing and translation regulation","description":"These proteins share GO terms related to mRNA splicing (cis splicing and spliceosome regulation), mRNA processing and export, mRNA modification, and translation initiation/regulation (translation reinitiation, preinitiation complex formation). The coherence across splicing, processing, export, and subsequent translation steps suggests a functional cluster centered on mRNA maturation and control of translation.","confidence":"High","size":16,"edges":8,"triangles":0,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":8},{"id":"GO:0002188","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0048025","count":7},{"id":"GO:0045292","count":7}]},{"hash":"1587920083981323029","title":"Neural Development and Synaptic Signaling","description":"The cluster is dominated by neural-related GO terms: excitatory postsynaptic potential, long-term synaptic potentiation, axonogenesis, Schwann cell development, and visual perception, plus calcium ion transmembrane transport, all pointing to neuronal development and synaptic communication. A few terms (lipopolysaccharide biosynthetic process, mitotic cell cycle, heart development) appear peripheral or noisy, but the core signal supports neural development and synaptic function.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070588","count":4},{"id":"GO:0043065","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0014044","count":3},{"id":"GO:0060291","count":3}]},{"hash":"1725114322586352316","title":"DNA replication and genome maintenance","description":"The top terms cluster around DNA replication, transcription, chromatin localization, and DNA repair (e.g., DNA replication, DNA-templated transcription, mitotic checkpoint signaling, UV-damage excision repair, chromatin localization). These together suggest a module focused on preserving genome integrity during cell cycle and DNA processing. A few secondary terms related to trafficking or organelle maintenance appear but are less central to the core function of the cluster.","confidence":"High","size":16,"edges":15,"triangles":0,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0033314","count":3},{"id":"GO:0071169","count":3},{"id":"GO:0070914","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006260","count":3}]},{"hash":"2239969440869055227","title":"RNA processing and translation initiation","description":"The top terms center on mRNA processing and regulation (splicing, export, stability, and modification) together with translation initiation/reinitiation, indicating a cluster of proteins involved in RNA metabolism and the initiation of protein synthesis.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":13},{"id":"GO:0006378","count":11},{"id":"GO:0048026","count":10},{"id":"GO:0045292","count":10},{"id":"GO:0031047","count":10}]},{"hash":"1949321379984215995","title":"Gene Expression and Chromatin Regulation","description":"This cluster centers on core gene expression processes: DNA-templated transcription, translation, and ribosome biogenesis, along with chromatin-related regulation such as histone H3K4 trimethylation and histone acetylation, heterochromatin control, and imprinting. Although a few peripheral terms exist (e.g., IL-2 regulation), the dominant theme links transcriptional activity with chromatin state and ribosome biogenesis, representing a cohesive gene-expression machinery module.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0080182","count":1},{"id":"GO:2000873","count":1}]},{"hash":"1702960991425513313","title":"Protein quality control: ubiquitination and autophagy","description":"The cluster is dominated by GO terms related to ubiquitin-like and ubiquitin-dependent processes (protein sumoylation, deubiquitination, ERAD pathway, proteasomal degradation) and autophagy (aggrephagy), pointing to a cohesive group of proteins involved in proteostasis and clearance of damaged proteins via ubiquitin-proteasome and autophagic pathways.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":11},{"id":"GO:0033132","count":11},{"id":"GO:0030433","count":11},{"id":"GO:0016579","count":10},{"id":"GO:1905366","count":10}]},{"hash":"689311265561027252","title":"Developmental signaling and endocytosis regulators","description":"TheTop terms include endocytosis, neurotrophin TRK receptor signaling, and multiple development-related terms (retina development, heart development, thymus development). There are also regulatory processes like positive regulation of GTPase activity and ER stress\u2013related apoptotic signaling, suggesting these proteins participate in signaling and trafficking pathways that influence tissue development and cell survival rather than a single, narrow function. This points to a cohesive theme of developmental signaling intertwined with endocytic regulation, hence the label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:0048011","count":3},{"id":"GO:0014911","count":3},{"id":"GO:0051902","count":3},{"id":"GO:0060041","count":3}]},{"hash":"259012421471274998","title":"Embryonic Metabolism and Redox Signaling","description":"The cluster is dominated by central metabolism terms, including glycolytic processes and amino acid catabolism (L-alanine and L-valine), along with cellular redox homeostasis and responses to oxidative conditions. Developmental terms such as in utero embryonic development, neuron maturation, and stem cell proliferation indicate a link between metabolic state and developmental progression. Together, these patterns point to a theme of metabolism intertwined with redox regulation during embryonic development and differentiation, hence the label Embryonic Metabolism and Redox Signaling.","confidence":"Medium","size":16,"edges":112,"triangles":458,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":8},{"id":"GO:0006574","count":7},{"id":"GO:2000648","count":7},{"id":"GO:0006096","count":7},{"id":"GO:0045454","count":7}]},{"hash":"1468382642871687837","title":"Spindle assembly and microtubule dynamics","description":"This cluster's top GO terms cluster around microtubule dynamics and spindle control, including regulation of microtubule-based processes, mitotic spindle elongation, plus-end and cytoplasmic microtubule depolymerization, and kinetochore attachment. Some terms touch on meiotic spindle orientation and karyogamy, reinforcing a common theme of spindle function during cell division. A few other terms relate to tissue architecture, suggesting broader roles in cytoskeletal organization. Overall, the shared function appears to be microtubule dynamics and spindle assembly/attachment.","confidence":"High","size":16,"edges":31,"triangles":26,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0032886","count":13},{"id":"GO:0000742","count":13},{"id":"GO:0036334","count":13},{"id":"GO:0000022","count":13},{"id":"GO:0070462","count":13}]},{"hash":"535624768774792291","title":"Endosomal sorting and vesicle trafficking","description":"The top GO terms are centered on the multivesicular body sorting pathway and endocytosis, with additional signals toward regulation of synaptic vesicle exocytosis. While there are some terms related to cell growth or muscle signaling, the strongest and most consistent theme across the cluster is vesicle trafficking and endosomal sorting, particularly the multivesicular body pathway. This makes Endosomal sorting and vesicle trafficking a concise, representative label.","confidence":"High","size":16,"edges":31,"triangles":15,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071985","count":16},{"id":"GO:0010796","count":16},{"id":"GO:2000300","count":16},{"id":"GO:0031384","count":16},{"id":"GO:1902236","count":14}]},{"hash":"2300025472997245617","title":"Vascular development and angiogenesis signaling","description":"The cluster is enriched for angiogenesis and VEGF signaling-related GO terms, including vascular endothelial growth factor signaling, endothelial cell proliferation/migration, and branching in blood vessel morphogenesis, plus embryonic epithelium morphogenesis. This constellation supports a cohesive role in vascular development and endothelial patterning.","confidence":"High","size":16,"edges":13,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0030947","count":3},{"id":"GO:0038084","count":3},{"id":"GO:0001938","count":3},{"id":"GO:1900746","count":3}]},{"hash":"2019842780868050708","title":"Endosomal trafficking and signaling proteins","description":"The top GO terms point to vesicle trafficking (endosome to plasma membrane transport, synaptic vesicle clustering) and signaling responses (interferon responses, glucose import in response to insulin, responses to biotic stimuli). While bone-related processes appear, the common thread is proteins involved in intracellular transport and signaling across contexts, rather than a single specialized function. Therefore, a label centered on endosomal trafficking and signaling best captures the shared theme of the cluster.","confidence":"Medium","size":16,"edges":117,"triangles":521,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":4},{"id":"GO:0035455","count":4},{"id":"GO:0050884","count":4},{"id":"GO:0097091","count":4},{"id":"GO:0046597","count":4}]},{"hash":"306665609345797987","title":"Central carbon metabolism and energy production","description":"The cluster shows strong representation of glycolysis, the TCA cycle, acetyl-CoA formation, gluconeogenesis, and amino-acid catabolism feeding into energy pathways, with associated fatty acid biosynthesis\u2014together defining central carbon metabolism and energy generation. Minor sodium transport is present but does not define the cluster.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006099","count":8},{"id":"GO:0006096","count":8},{"id":"GO:0033512","count":7},{"id":"GO:0042759","count":5},{"id":"GO:2001295","count":5}]},{"hash":"861028099738658050","title":"TGF-\u03b2/SMAD Signaling Regulators","description":"The top GO terms point to regulation and response within the TGF-\u03b2/SMAD axis (negative regulation of TGF-\u03b2 receptor signaling, cellular response to TGF-\u03b2 stimulus, SMAD-related assembly regulation, and related dephosphorylation activities). This suggests the proteins function primarily as modulators of TGF-\u03b2 signaling, possibly including control of SMAD phosphorylation and nuclear translocation. Some terms also reference broader developmental processes, but the core theme is TGF-\u03b2/SMAD pathway regulation.","confidence":"High","size":16,"edges":113,"triangles":469,"max_degree":15,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0030512","count":11},{"id":"GO:0042006","count":8},{"id":"GO:0061191","count":8},{"id":"GO:0042347","count":8},{"id":"GO:0035970","count":8}]},{"hash":"1455603226729771995","title":"Diverse Substrate Membrane Transporters","description":"The top GO terms all describe transmembrane transport of a wide range of substrates (vitamins, xenobiotics, phosphate, sodium, sugars, amino acids, and other molecules) and even processes like neurotransmitter loading into synaptic vesicles. This points to a cluster of membrane transporter proteins with broad substrate specificity rather than a single, specific transport pathway. ","confidence":"High","size":16,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":12},{"id":"GO:0006855","count":12},{"id":"GO:0035435","count":11},{"id":"GO:0042891","count":11},{"id":"GO:0098700","count":10}]},{"hash":"497566592505588281","title":"Mitotic cell cycle control and developmental signaling","description":"The cluster is enriched for mitosis-related processes (mitotic spindle assembly; mitotic cell cycle) and kinase signaling regulation (positive regulation of protein serine/threonine kinase activity; protein autophosphorylation), with supporting roles in GTPase activity control and mRNA transport, alongside developmental terms (multicellular organism development, skeletal system development). This suggests a cohesive set of proteins coordinating cell division, signaling, and developmental processes, with some stress response components (hypoxia) also represented. ","confidence":"High","size":16,"edges":43,"triangles":46,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0071456","count":7},{"id":"GO:0031954","count":6},{"id":"GO:0051028","count":6},{"id":"GO:0090307","count":6}]},{"hash":"1633438969966639139","title":"Embryonic organ morphogenesis","description":"These GO terms cluster around developmental and morphogenetic processes across multiple organs (eye, heart/outflow tract, hindlimb, placenta, prostate, habenula), plus general multicellular organism development and myoblast proliferation. The shared theme is organ formation and tissue shaping during embryogenesis, making this a concise, representative label for the cluster.","confidence":"High","size":16,"edges":22,"triangles":5,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0001890","count":6},{"id":"GO:0008584","count":6},{"id":"GO:0035116","count":6}]},{"hash":"1033962494055614946","title":"Developmental differentiation and Notch regulation","description":"The top terms include gamma-delta T cell differentiation, lamellocyte differentiation, and cardiac neural crest\u2013related development, along with negative regulation of Notch signaling, pointing to a broad role in development and cell fate decisions. While other terms touch on synaptic/exocytosis processes, the dominant theme is differentiation and developmental signaling, suggesting this cluster centers on developmental regulation rather than a single tissue function.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045746","count":3},{"id":"GO:0042492","count":2},{"id":"GO:0035171","count":2},{"id":"GO:0030194","count":2}]},{"hash":"678320930248681163","title":"Embryonic adhesion and morphogenesis with angiogenesis regulation","description":"The top GO terms cluster around cell adhesion (heterophilic and cell-matrix), developmental processes (somitogenesis, loop of Henle development, cardiac neural crest morphogenesis), and negative regulation of angiogenesis/ endothelial differentiation, suggesting a group of proteins involved in embryonic tissue morphogenesis and vascular remodeling. The complement activation term appears less central, but overall the cluster centers on developmental adhesion and morphogenesis with angiogenesis control.","confidence":"Medium","size":16,"edges":19,"triangles":4,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":13},{"id":"GO:0071372","count":13},{"id":"GO:0007160","count":12},{"id":"GO:0001867","count":11},{"id":"GO:0042492","count":11}]},{"hash":"1965699601876188888","title":"Apoptosis and Innate Immunity","description":"The top GO terms are dominated by apoptotic and pyroptotic inflammatory processes (apoptotic process, pyroptotic inflammatory response), along with innate immune response and protein ubiquitination, suggesting a theme around stress-induced cell death and immune signaling, with additional terms like ribosome biogenesis and mRNA splicing likely reflecting broader cellular maintenance roles or annotation noise. This supports a cohesive label centered on programmed cell death and immune regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":10},{"id":"GO:0045087","count":10},{"id":"GO:0006915","count":9},{"id":"GO:0070269","count":8},{"id":"GO:0016567","count":8}]},{"hash":"2037550351718347570","title":"Cell Cycle Regulation and Developmental Patterning","description":"This cluster centers on processes that regulate cell division and chromosomal dynamics (regulation of cell cycle, centromeric cohesion) and developmental signaling and morphogenesis (Wnt signaling regulation, metanephros morphogenesis, desmosome assembly, pattern formation), with additional terms hinting at broader architectural regulation across species (plant cell wall biogenesis, nucleus\u2013vacuole junction). The mix suggests a regulatory hub for growth and tissue organization, though the cross-kingdom terms indicate some heterogeneity.","confidence":"Medium","size":16,"edges":111,"triangles":470,"max_degree":15,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":13},{"id":"GO:0035293","count":12},{"id":"GO:1904793","count":12},{"id":"GO:0070602","count":12},{"id":"GO:0090090","count":12}]},{"hash":"514303560337793272","title":"Developmental differentiation and NF-kappaB signaling","description":"The top GO terms point to various developmental processes across tissues (male gonad, neuron projection, skeletal, lens fiber differentiation, multicellular organism development) and include NF-kappaB\u2013related signaling and defense responses. This suggests the cluster comprises proteins involved in developmental differentiation with regulatory links to NF-kappaB pathways, even though there are no observed interactions among the proteins in this cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0050830","count":2}]},{"hash":"789516767564862406","title":"Neural development and myelination with immune signals","description":"The top GO terms cluster around neural development processes such as synapse assembly, axonal fasciculation, and myelination, indicating a core theme of neural maturation and connectivity. The presence of innate immune response and dendritic cell cytokine production suggests additional immune signaling roles for these proteins, hinting at possible nervous-immune interactions. Some terms like otolith morphogenesis, angiogenesis, and skeletal system development appear as broader developmental contexts, but the dominant signal remains neural development with myelination, possibly with immune-related functions.","confidence":"Medium","size":16,"edges":60,"triangles":77,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":9},{"id":"GO:0051965","count":8},{"id":"GO:0042552","count":8},{"id":"GO:0045087","count":7},{"id":"GO:0007413","count":7}]},{"hash":"580094359785786045","title":"Innate Immune Surveillance and Cell Adhesion","description":"The top GO terms cluster around innate immunity (innate immune response, phagocytosis, detection of tumor cell, susceptibility to T cell cytotoxicity) and cell-cell interactions (cell adhesion, localization to cell junction). This suggests the proteins may function in immune surveillance and coordination of adhesion/junctional signaling during immune responses. Some developmental terms appear but do not define the core theme of this cluster.","confidence":"Medium","size":16,"edges":20,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060370","count":3},{"id":"GO:0045663","count":3},{"id":"GO:0043031","count":3},{"id":"GO:0006911","count":3},{"id":"GO:0007286","count":3}]},{"hash":"1566674455027871853","title":"Unknown","description":"The GO terms span diverse biology (development in vertebrates and plants, cell cycle, translation initiation, GTPase regulation, lipid mediator biosynthesis, mucus secretion, and metabolic signaling) with no obvious shared function across the cluster; the absence of edges also suggests no coherent pathway tying these proteins together.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021510","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0001731","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0080086","count":2}]},{"hash":"113310873855309714","title":"Placental and Embryonic Morphogenesis","description":"Most terms point to developmental and morphogenetic processes in early embryogenesis, especially placental (trophoblast giant cell differentiation, placental/embryonic development) and heart/left-right patterning, with cartilage morphogenesis also represented. A few terms reflect general gene expression processes, but the dominant theme is embryonic tissue development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":8},{"id":"GO:0060536","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0060972","count":7},{"id":"GO:0003198","count":7}]},{"hash":"1108051502994233849","title":"Metabolic signaling and thermogenesis","description":"The top GO terms point to energy metabolism (electron transport chain, membrane potential, diet-induced thermogenesis) combined with signaling pathways (adenylate cyclase-activating GPCR signaling, Rho signaling), which together suggest a theme where cellular metabolism integrates with signal transduction, possibly affecting cardiovascular and neural functions. A couple of terms (nipple morphogenesis, operant conditioning) seem less related and may reflect annotation noise. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0071502","count":12},{"id":"GO:0042391","count":12}]},{"hash":"444807061440050225","title":"Innate immunity and platelet development signaling","description":"The cluster shows strong representation of innate immune response terms and platelet-related processes (platelet formation, megakaryocyte development, platelet degranulation) as well as Fc-epsilon receptor signaling, suggesting a shared theme of immune-platelet signaling. While pigmentation and neurotransmitter terms appear, the dominant pattern ties immune signaling to platelet/megakaryocyte biology, justifying a combined label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0098735","count":2},{"id":"GO:0031284","count":2},{"id":"GO:0030318","count":2},{"id":"GO:0030220","count":2}]},{"hash":"339219265586571978","title":"Chromatin Regulation and Gene Expression","description":"This cluster centers on nuclear gene expression and chromatin dynamics, with GO terms for DNA-templated transcription, histone methylation/acetylation, and mRNA splicing, and includes translation preinitiation complex formation as part of gene expression machinery, while development and signaling terms appear as broader context.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051567","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0032933","count":3}]},{"hash":"2012085775483206220","title":"Vertebrate neural and mesodermal development","description":"The top GO terms cluster around neural development (cerebral cortex development, neuron projection development, neural crest cell migration, sympathetic nervous system development) and mesoderm- and skeletal-related processes (paraxial mesoderm development, skeletal system development, multicellular organism development, spermatid development). Regulation of Rho signaling aligns with cytoskeletal changes and cell movement typical of morphogenesis. A couple of immune signaling terms (B cell receptor signaling, TNF production) appear less central, but overall the set points to vertebrate neural and mesodermal development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0021987","count":2},{"id":"GO:0031175","count":2},{"id":"GO:1904469","count":2},{"id":"GO:0048339","count":2}]},{"hash":"2290828893991633220","title":"Cardiac electrical conduction and mechanoresponse","description":"Top GO terms indicate emphasis on cardiac excitability, SA node action potential regulation, electrical coupling, and mechanical stimulus responses, suggesting a cluster of proteins involved in cardiac electrophysiology and mechano-sensing. Some non-cardiac terms appear but the dominant signal supports this cardiac function theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900827","count":3},{"id":"GO:0072660","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0010650","count":3},{"id":"GO:0045083","count":3}]},{"hash":"1976619635033042446","title":"Neurodevelopment and inflammatory signaling","description":"The top terms point to neural development (pyramidal neuron differentiation, axon guidance, heart development) together with immune/inflammatory regulation (chemokine production, neutrophil extravasation, IL-1 signaling, NF-kappaB-related activity) and general signaling pathways (Rho, PI3K). This suggests a cluster of proteins involved in neural development with concurrent modulation of inflammatory and immune signaling, rather than a single, cohesive function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0021859","count":3},{"id":"GO:2000391","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0014068","count":3}]},{"hash":"596491548660878024","title":"Unknown","description":"This cluster\u2019s GO terms span signaling, sensory and neural development, cell division, immune processes, viral mRNA export, and gamete-related functions with no clear shared theme, and there are no edges connecting the proteins, so a cohesive functional label is not supported.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0007018","count":2}]},{"hash":"1697357972350758408","title":"Axon guidance and synapse formation with hormonal signaling","description":"The top GO terms center on neuronal development (axon extension, axon guidance, synapse assembly) alongside hormonal responses (FSH stimulus, cortisol) and inflammatory signaling, suggesting a cluster of proteins involved in neural connectivity and signaling regulation. This name captures the core neural-development theme while noting the hormonal/inflammatory signaling context.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019800","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0006954","count":10},{"id":"GO:0071372","count":10},{"id":"GO:0021972","count":10}]},{"hash":"778020226799792310","title":"Vascular development and immune signaling","description":"The cluster centers on processes related to blood vessel formation and endothelial dynamics (angiogenesis, endothelial cell migration, lymph vessel morphogenesis) as well as immune-related signaling (complement activation, Fc-gamma receptor signaling, leukocyte tethering/rolling). The presence of ERK1/2 cascade regulation suggests shared signaling pathways linking these vascular and immune functions. While a kidney development term and a senescence link appear, the dominant theme is angiogenesis with vascular-immune interactions, making this label representative of the cluster.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0001867","count":2},{"id":"GO:0043536","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0072218","count":1}]},{"hash":"168514434700834586","title":"Neuronal development and vesicle trafficking","description":"Top terms point to neural development (retina layer formation, limbic system and sympathetic ganglion development) along with synaptic/vesicular trafficking (regulation of synaptic vesicle endocytosis, early endosome localization). While a couple of terms are more general (carbohydrate metabolism, HGF receptor signaling), the dominant theme is neural development coupled with intracellular trafficking at synapses and axons. This justifies a label focused on neuronal development with vesicle/endosome dynamics.","confidence":"Medium","size":15,"edges":59,"triangles":113,"max_degree":14,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:1900242","count":8},{"id":"GO:0010842","count":8},{"id":"GO:0016062","count":7},{"id":"GO:0021761","count":7},{"id":"GO:0005975","count":7}]},{"hash":"2055573027239638925","title":"Nucleobase and Purine Transport","description":"This cluster centers on transport of nucleobases and purines (hypoxanthine, urate, uracil, guanine, adenine, xanthine) across the plasma membrane, consistent with a nucleobase/purine transporter role; a few unrelated terms (defense response to Gram-positive bacteria, intestinal cholesterol absorption) are present but do not define the core function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035344","count":3},{"id":"GO:0070904","count":3},{"id":"GO:0015747","count":3},{"id":"GO:0098721","count":3},{"id":"GO:1903825","count":3}]},{"hash":"2034301066329956637","title":"Calcium/NFAT Signaling in Muscle and Nervous Development","description":"The cluster centers on calcium-dependent calcineurin-NFAT signaling, with multiple terms for NFAT pathway activity and calcium ion detection. This is complemented by GO terms linking to muscle development and function (skeletal muscle fiber development, muscle filament sliding speed) and nervous/vascular development (Schwann cell development, visual perception, branching in blood vessel morphogenesis), suggesting a cohesive theme of calcium-driven signaling coordinating muscle, nerve, and vessel formation and function.","confidence":"Medium","size":15,"edges":18,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051533","count":3},{"id":"GO:1905205","count":2},{"id":"GO:0033173","count":2},{"id":"GO:0032972","count":2},{"id":"GO:0014044","count":2}]},{"hash":"2190857937158328049","title":"N-terminal and histone acetylation in chromatin","description":"The top GO terms are dominated by acetylation-related processes (N-terminal acetylation, N-terminal propionylation, peptidyl-lysine acetylation, histone H4 acetylation) and chromatin-associated functions (subtelomeric heterochromatin formation, centromeric cohesion), suggesting a chromatin-regulatory cluster centered on acetylation. Peripheral metabolic terms are likely ancillary. ","confidence":"High","size":15,"edges":84,"triangles":248,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":12},{"id":"GO:0017196","count":11},{"id":"GO:0046208","count":11},{"id":"GO:0071962","count":11},{"id":"GO:0019491","count":11}]},{"hash":"2111084040803998610","title":"Unknown","description":"The top GO terms cover a wide range of biology: amino acid catabolism and biosynthesis (alanine, kynurenine, glutamate, lysine; cobalamin and heme biosynthesis), DNA-templated transcription, and signaling/defense (Notch signaling, salicylic acid\u2013mediated systemic acquired resistance). This mix does not point to a single coherent functional theme or module for the cluster, making a specific, representative name difficult. ","confidence":"","size":15,"edges":89,"triangles":341,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":9},{"id":"GO:0007219","count":9},{"id":"GO:0097053","count":9},{"id":"GO:0009236","count":8},{"id":"GO:0033512","count":8}]},{"hash":"331111111934440361","title":"ER Protein Folding and Stress Response","description":"This cluster is dominated by GO terms about endoplasmic reticulum\u2013based protein folding, unfolded protein response, chaperone-assisted refolding, and ER-associated degradation, all hallmark features of ER quality control under proteotoxic stress. Additional terms for redox/oxidative stress and translation initiation regulation under ER stress support a coherent theme of adaptive cellular response to misfolded proteins in the ER, with some related transcriptional activity reflecting downstream signaling. ","confidence":"High","size":15,"edges":17,"triangles":7,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":11},{"id":"GO:0006986","count":10},{"id":"GO:0045454","count":10},{"id":"GO:0070389","count":8},{"id":"GO:0030433","count":8}]},{"hash":"715104720617465139","title":"Membrane Transporters for Small Molecules","description":"The top GO terms point to diverse transmembrane transporter activities: D-glucose transmembrane transport, myo-inositol transport, biotin and pantothenate transport, sodium ion export, and sodium-independent transport of organic anions and lipids. This pattern indicates a cluster enriched for membrane transporter proteins that mediate uptake or efflux of various metabolites and ions across membranes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":4},{"id":"GO:0015798","count":3},{"id":"GO:0071436","count":3},{"id":"GO:0015878","count":3},{"id":"GO:0015887","count":3}]},{"hash":"1187395839236605188","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning chromatin modification, multiple biosynthetic pathways across bacteria and plants, neuron development, angiogenesis, and protein acetylation, with no single shared function linking the proteins; there are no edges connecting members, indicating no cohesive cluster signal. ","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":3},{"id":"GO:0019491","count":3},{"id":"GO:0048666","count":3},{"id":"GO:0018003","count":3},{"id":"GO:0001525","count":3}]},{"hash":"1301000714104991460","title":"Glycosylation and glycan biosynthesis in immune and neural development","description":"The top GO terms cluster around fucose-containing glycan biosynthesis and glycoprotein/fucosylation pathways (L-fucose catabolic process, Lewis a epitope biosynthesis, N-glycan fucosylation, protein glycosylation) as well as proteoglycan synthesis (heparan sulfate/heparin). These glycans govern cell\u2013cell interactions and signaling, which aligns with leukocyte migration and regulatory T cell differentiation in the immune system, and with cerebral cortex neuronal migration and neural stem cell maintenance in the brain. Thus the common theme is glycosylation/glycan biosynthesis shaping immune and neural development.","confidence":"High","size":15,"edges":15,"triangles":1,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042355","count":4},{"id":"GO:0002522","count":4},{"id":"GO:0097150","count":4},{"id":"GO:0002361","count":4},{"id":"GO:0010493","count":4}]},{"hash":"81660124025535005","title":"Mitochondrial respiration and ubiquinone biosynthesis","description":"The dominant GO terms center on mitochondrial electron transport (NADH to ubiquinone) and ATP synthesis coupled electron transport, plus regulation of ubiquinone biosynthesis, pointing to energy production and cofactor biosynthesis. Some accompanying terms (lipid homeostasis and transport) fit membrane-associated energy systems, while a couple of terms appear less related (e.g., photosynthesis, Purkinje cell morphogenesis) and may reflect broad annotations. Overall, the cluster seems linked to mitochondrial respiration and ubiquinone-related biosynthesis. ","confidence":"High","size":15,"edges":101,"triangles":406,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":1},{"id":"GO:0030004","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0042773","count":1},{"id":"GO:0019684","count":1}]},{"hash":"1002107510312340002","title":"Unknown","description":"The top GO terms are highly diverse, spanning development (retina and nipple morphogenesis), general cell proliferation, nervous/physiological regulation (blood pressure, heart rate, vasoconstriction), renal function, learning (operant conditioning), and signaling (GTPase activity). There isn't a single cohesive biological function or pathway that ties these terms together, so a concise, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":15},{"id":"GO:0060041","count":15},{"id":"GO:0008283","count":15},{"id":"GO:0008284","count":15},{"id":"GO:0060658","count":14}]},{"hash":"1466957261375592225","title":"Mitotic progression and transcription regulation","description":"This cluster is dominated by GO terms related to cell-cycle control and mitosis (G1/S and G2/M transitions, re-entry into mitosis, and spindle pole separation) alongside DNA-templated transcription and its regulation, suggesting a coordinated program where transcriptional activity aligns with mitotic progression. Minor tissue- or growth-related terms (mammary gland proliferation, insulin signaling) appear, but the core theme centers on cell-cycle regulation and transcription during division.","confidence":"High","size":15,"edges":33,"triangles":27,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0046626","count":12},{"id":"GO:0010696","count":12},{"id":"GO:0033598","count":12},{"id":"GO:0000082","count":12}]},{"hash":"578830934542026685","title":"Inflammation, complement, and coagulation responses","description":"This cluster centers on innate immune and hemostatic processes: complement activation (lectin pathway), platelet activity and coagulation, inflammatory signaling (interleukin-1 response), and clearance of apoptotic cells, with additional hints of tissue stress and repair (UV-B response, axon regeneration at NMJ) and secreted mediators. The convergence of these GO terms suggests a cohesive inflammatory/immune-hemostatic response theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050714","count":9},{"id":"GO:0001867","count":8},{"id":"GO:0071347","count":8},{"id":"GO:0072378","count":8},{"id":"GO:0071493","count":8}]},{"hash":"2276354270018301785","title":"Adrenergic GPCR signaling and blood pressure control","description":"These proteins appear enriched for adrenergic signaling and cardiovascular regulation: activation of adenylate cyclase, GPCR signaling, norepinephrine/epinephrine\u2013mediated vasoconstriction and heart rate regulation, and renal sodium handling. The dominant theme is catecholamine-driven cardiovascular responses, with some annotations (nipple morphogenesis, operant conditioning) likely noise. ","confidence":"Medium","size":15,"edges":41,"triangles":34,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":14},{"id":"GO:0007190","count":14},{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0060658","count":13}]},{"hash":"1090135402039511288","title":"Neurodevelopment, Adhesion, and Immune Signaling","description":"GO terms cluster around neural development and morphogenesis, with strong signals for cell adhesion; immune signaling terms (T cell costimulation, complement activation, macrophage regulation) and ROBO-related signaling link cell\u2013cell communication during development.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045663","count":5},{"id":"GO:0007155","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0031295","count":4},{"id":"GO:0006958","count":4}]},{"hash":"1572862568194363400","title":"Ubiquitin-dependent proteolysis and cell cycle control","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes, including SCF-dependent ubiquitin\u2013proteasomal degradation and mitotic G1 DNA damage checkpoint signaling, which strongly points to regulation of protein turnover during the cell cycle. Additional terms on circadian rhythm regulation and developmental/neural events can be linked to ubiquitin-mediated timing and turnover of key regulators in development; together they suggest a unified theme of ubiquitin-proteasome\u2013driven control of cell division and associated signaling pathways.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0031571","count":11},{"id":"GO:0031146","count":11},{"id":"GO:0042752","count":11},{"id":"GO:0071406","count":11}]},{"hash":"1122376786221099442","title":"Golgi-ER vesicle trafficking and synaptic exocytosis","description":"The terms cluster around vesicle transport between the ER and Golgi and within the Golgi, SNARE-mediated fusion, and exocytic delivery of receptors to the postsynaptic membrane, linking Golgi trafficking to synaptic potentiation processes.","confidence":"High","size":15,"edges":31,"triangles":18,"max_degree":9,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048280","count":7},{"id":"GO:0006888","count":7},{"id":"GO:0006891","count":7},{"id":"GO:0060291","count":7},{"id":"GO:0090161","count":7}]},{"hash":"2066158583831412250","title":"Inflammation and Cardiovascular Development","description":"The top GO terms point to inflammatory response and cardiovascular morphogenesis, including coronary artery morphogenesis, cardiac neural crest\u2013driven outflow tract development, and blood coagulation processes. While a few terms relate to other areas (nerve extension, obsolete terms), the dominant themes link immune/inflammatory signaling with heart and vessel formation, justifying a single, concise label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006954","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0060982","count":5},{"id":"GO:0019800","count":4}]},{"hash":"1860912779260372064","title":"Neural development and axon regeneration","description":"This cluster is dominated by GO terms related to neural signaling and repair, including positive regulation of glutamatergic synaptic transmission and axon regeneration in the peripheral nervous system and at the neuromuscular junction. Supporting terms point to extracellular matrix remodeling and vascular changes (collagen fibril organization, plasminogen activation, platelet aggregation) that commonly accompany tissue remodeling during nervous system development and regeneration; a few terms about development in other organs may reflect broader involvement of these proteins in developmental processes beyond the nervous system.","confidence":"Medium","size":15,"edges":27,"triangles":14,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":9},{"id":"GO:0031639","count":8},{"id":"GO:0070527","count":8},{"id":"GO:0060739","count":8},{"id":"GO:0014012","count":8}]},{"hash":"172379415690204035","title":"Developmental signaling and ECM interactions","description":"These terms cluster around intercellular communication and signaling during development (reelin signaling, Wnt pathway regulation, cell-cell signaling in mammary gland development, retinal vessel morphogenesis) and extracellular matrix\u2013cell signaling, suggesting a common theme of tissue morphogenesis and ECM cross-talk. Vesicle trafficking and cholesterol response terms also appear, indicating links between membrane signaling, trafficking, and lipid-related regulation in developmental contexts. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0038026","count":6},{"id":"GO:1902953","count":5},{"id":"GO:0060764","count":4},{"id":"GO:0048539","count":4},{"id":"GO:0061304","count":4}]},{"hash":"1041269959265405881","title":"Synaptic Endocytosis and Receptor Trafficking","description":"The GO terms center on endocytosis and the transport of neurotransmitter receptors from endosomes to the postsynaptic membrane, along with SNARE disassembly and cytoskeletal/membrane polarity processes. This suggests a coherent theme of vesicle cycling and polarized receptor trafficking at synapses, supported by related actin dynamics and cell-shape polarity terms. Some terms like Cvt pathway reflect broader vesicular trafficking mechanisms but overall point to a synaptic trafficking focus.","confidence":"High","size":15,"edges":20,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:0098887","count":3},{"id":"GO:0030950","count":3},{"id":"GO:0071963","count":3},{"id":"GO:0031532","count":3}]},{"hash":"269923189159205916","title":"Neural development and signaling pathways","description":"This cluster is dominated by GO terms tied to brain and nervous system development, regulation of synaptic vesicle exocytosis, and key neural signaling routes (Roundabout and Hedgehog via Smoothened). While a couple of terms (T cell receptor signaling, 5S rRNA transcription) are less related, the strongest signals point to neuronal development and signaling as the core theme. Confidence: Medium","confidence":"","size":15,"edges":19,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0031384","count":2},{"id":"GO:0035385","count":2}]},{"hash":"1289574055048073175","title":"Neuronal development and cell adhesion","description":"This cluster centers on neural development processes: neuron migration, axon guidance, and both heterophilic and homophilic cell\u2013cell adhesion, with supporting signals for branching morphogenesis. These terms point to coordination of cell interactions and guidance cues during neural tissue formation, making \"neuronal development and cell adhesion\" a concise, representative label. A few terms about immune regulation may reflect shared signaling pathways but do not redefine the core theme.","confidence":"High","size":15,"edges":95,"triangles":346,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0060445","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0033564","count":2},{"id":"GO:0001764","count":2}]},{"hash":"267999668752868134","title":"Innate and adaptive immune signaling","description":"The cluster shows a strong representation of innate immune response, complement activation, and regulation of macrophage and T-cell activity (e.g., CD40 signaling and T cell cytotoxicity susceptibility), plus integrin-mediated signaling linked to leukocyte adhesion. While a few terms reference nervous system structures or metabolism, the dominant theme is immune activation and regulation, suggesting these proteins function together in immune signaling networks.","confidence":"Medium","size":15,"edges":31,"triangles":22,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0019433","count":4},{"id":"GO:0030913","count":4}]},{"hash":"1134394379056037104","title":"Sensory stimulus detection and sodium homeostasis","description":"The GO terms point to a core theme of detecting diverse sensory stimuli (temperature, mechanical, chemical) related to pain, along with taste (salty) and pH response, plus sodium ion transport/homeostasis. This suggests a cluster of proteins involved in sensory transduction and ionic balance, especially Na+. The absence of network edges doesn't negate the shared functional theme across these terms. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050965","count":4},{"id":"GO:0050966","count":4},{"id":"GO:0010447","count":4},{"id":"GO:0050914","count":4},{"id":"GO:0035199","count":4}]},{"hash":"822355537697240772","title":"Angiogenesis Regulation and ECM Remodeling","description":"The cluster is dominated by GO terms related to blood vessel formation and its control, including both positive and negative regulation of angiogenesis, endothelial cell migration, and lymphangiogenesis regulation. Additional terms for collagen fibril organization and fibrinolysis indicate extracellular matrix remodeling tied to vascular development. Immune and calcium signaling terms present may reflect interacting pathways, but the core pattern points to coordinated vascular growth and remodeling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0051592","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0001525","count":2}]},{"hash":"129190790643118271","title":"Embryonic and Placental Development","description":"The top GO terms cluster around developmental processes, especially placental/trophoblast differentiation (GO:0060707), endocrine system development (GO:000MX, but specifically GO:0008201? Actually GO:0035270), and embryonic patterning (left/right pattern formation GO:0060972; cartilage morphogenesis GO:0060536; EMT in endocardial cushion formation GO:0003198). These indicate a common theme of embryogenesis and lineage differentiation, including placental and endocrine contexts. Some terms pertain to general regulatory processes (RNA polymerase II regulation, splicing, DNA replication initiation), but the prevailing signal is developmental differentiation and organogenesis, particularly in placental/endocrine lineages.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0060536","count":6}]},{"hash":"56221938068317298","title":"Broad signaling and energy metabolism responses","description":"The proteins map to several GO terms focused on signaling (positive regulation of Rho GTPase signaling, GPCR-AC signaling, GTPase activity) and energy/metabolism (electron transport chain, diet-induced thermogenesis), with additional terms covering immune and xenobiotic responses, temperature-related and sensory processes (phototransduction). This mix suggests a broad collection of stimulus-response regulators rather than a single cohesive function, so a general label reflecting both signaling and metabolic stress aligns best.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":4},{"id":"GO:0035025","count":4},{"id":"GO:0010579","count":4},{"id":"GO:0022900","count":4},{"id":"GO:0006955","count":3}]},{"hash":"2165932989932460221","title":"TLR4-driven innate immune signaling","description":"The GO terms cluster around innate immune responses and inflammatory signaling triggered by TLR4/LPS, including MyD88-independent TLR signaling, interferon-beta production, cytokine signaling, and defense against Gram-negative bacteria, with some transcriptional regulation terms reflecting regulatory proteins. This indicates a coherent innate immunity theme rather than unrelated processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030512","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0034142","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0045087","count":2}]},{"hash":"577797626823788268","title":"Unknown","description":"The GO terms span immune signaling (B and T cell regulation, LPS response), development (forebrain development, multicellular growth), signaling pathways (TGF-beta, NF-kappaB), and also include viral mRNA export and telomerase RNA stabilization, with no clear, unifying function linking all proteins; thus no coherent cluster theme can be assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0046784","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0030889","count":2}]},{"hash":"1340013561025005000","title":"Unknown","description":"These proteins show a highly diverse set of GO terms spanning nervous system regulation, muscle contraction, protein trafficking, metabolism, and immune regulation, with no clear, single shared function or pathway linking all members. Therefore a coherent, informative cluster label cannot be determined from the provided terms.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048168","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0070863","count":2},{"id":"GO:0055114","count":1},{"id":"GO:0010039","count":1}]},{"hash":"1556882519392429792","title":"Leukocyte adhesion and complement signaling","description":"This cluster's top GO terms cluster around leukocyte tethering/rolling, heterophilic cell\u2013cell adhesion, and complement receptor signaling/activation, which together point to immune cell adhesion and innate immune signaling. Additional terms for extrinsic apoptotic signaling and platelet activation fit into immune-coagulation cross-talk, while a couple of outliers (symbiont entry, response to cocaine) do not override the core theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050901","count":3},{"id":"GO:0097192","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0002430","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1636214724273161106","title":"Pyroptosis, Apoptosis, and Innate Immunity via Ubiquitination","description":"Top GO terms cluster around apoptotic process, pyroptotic inflammatory response, innate immune response, and protein ubiquitination, suggesting involvement in inflammatory programmed cell death and ubiquitin-regulated immune signaling. While some terms relate to transcription and DNA repair, they are secondary to the dominant death-immunity-ubiquitination theme, supporting a cohesive role in inflammatory cell death and ubiquitin-mediated regulation.","confidence":"High","size":14,"edges":21,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":10},{"id":"GO:0070269","count":10},{"id":"GO:0016567","count":10},{"id":"GO:1990001","count":10},{"id":"GO:0045087","count":10}]},{"hash":"569435248472513790","title":"Apoptosis and differentiation regulation via ubiquitination","description":"This cluster centers on processes that control cell fate: apoptosis, various differentiation programs (including keratinocytes and neurons), and signaling pathways like Hippo. The ubiquitin system is recurrent (monoubiquitination, K63-linked ubiquitination, autoubiquitination, and related turnover of signaling components such as SMAD), suggesting regulation of these fate decisions through protein modification and degradation. The combination of apoptotic signaling, differentiation, and ubiquitin-dependent regulation provides a coherent theme for this cluster, despite including multiple differentiation contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0048813","count":2},{"id":"GO:0018107","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0035329","count":2}]},{"hash":"524967378562659271","title":"Developmental signaling and differentiation cues","description":"The proteins in this cluster touch on myoblast differentiation, axial mesoderm formation, angiogenesis, neurotransmitter secretion, and synapse assembly, plus immune signaling (interleukin-1 and T cell receptor pathways) and calcium-channel activation, with additional roles in integrin-mediated adhesion and cell cycle progression. This points to a broad, interconnected developmental signaling theme spanning muscle, neural, vascular, and immune contexts, rather than a single specific pathway.","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045663","count":2},{"id":"GO:0070498","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007269","count":2},{"id":"GO:0050852","count":2}]},{"hash":"2072938572216526297","title":"Mitotic division and spindle assembly","description":"The top terms cluster around mitotic processes (mitotic cell cycle, mitotic spindle assembly, cell division) and regulation of kinase and GTPase activities, suggesting proteins that participate in mitosis and control of division machinery, with additional ties to RNA transport and development.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070208","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0090307","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0043547","count":6}]},{"hash":"491221176232416236","title":"Neural signaling and receptor trafficking","description":"This cluster centers on neuronal processes such as neuroblast differentiation, acetylcholine catabolic activity in the synapse, receptor internalization, and regulation of receptor recycling, suggesting a coherent theme of neural signaling and membrane receptor trafficking. Some terms (plant carbohydrate metabolism) appear unrelated and may reflect noise in annotations, but the core pattern supports neural signaling and receptor regulation. ","confidence":"Medium","size":14,"edges":29,"triangles":15,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001507","count":3},{"id":"GO:0030245","count":3},{"id":"GO:0031623","count":3},{"id":"GO:0014016","count":3},{"id":"GO:0043279","count":3}]},{"hash":"420415426904644177","title":"Post-transcriptional mRNA processing and translation control","description":"The proteins are enriched for mRNA maturation (polyadenylation, splicing, export, modification), stress-related mRNA stability regulation, and initiation of translation (preinitiation complex formation and translational initiation regulation), indicating a cohesive cluster focused on post-transcriptional gene expression and translation control.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":9},{"id":"GO:0010610","count":8},{"id":"GO:0002188","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0016556","count":7}]},{"hash":"1471104016541170925","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000466","count":4},{"id":"GO:0000472","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000462","count":3}]},{"hash":"2175715869237836162","title":"Glucocorticoid signaling and skin apoptosis","description":"The cluster features GO terms centered on glucocorticoid signaling, skin development, and intrinsic mitochondrial apoptosis (cytochrome c release and DNA-damage\u2013related apoptotic signaling), plus innate immune responses. This pattern suggests a cohesive stress-response module in skin influenced by glucocorticoids and linked to apoptosis and defense pathways.","confidence":"Medium","size":14,"edges":24,"triangles":13,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042921","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0001836","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1264704516760601619","title":"Antibiotic and quinone biosynthesis","description":"The cluster is enriched for GO terms related to antibiotic biosynthetic process and biosynthesis of quinones (menaquinone and phylloquinone), indicating a shared role in producing antibiotics and quinone cofactors. Additional catabolic terms (L-valine, phenylacetate, and fatty acid \u03b2-oxidation) appear, but the dominant signal points to biosynthetic pathways, justifying the label.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":13},{"id":"GO:0009234","count":12},{"id":"GO:0042372","count":12},{"id":"GO:0006574","count":12},{"id":"GO:0006635","count":12}]},{"hash":"1290365271656211465","title":"Presynaptic assembly and neuronal signaling","description":"Several top terms emphasize presynapse assembly, receptor recycling, and visual perception, indicating a neural/synaptic function. Regulated Ran signaling and GTPase activity further support a role in neuronal signaling. Some cell-cycle terms may be incidental. The cluster therefore best fits function in synapse formation and neural signaling.","confidence":"Medium","size":14,"edges":84,"triangles":291,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050709","count":13},{"id":"GO:0042068","count":13},{"id":"GO:0007117","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0001881","count":13}]},{"hash":"865321284134988900","title":"Photosynthesis-Linked Metabolic Pathways","description":"The top GO terms point to plastidial metabolism and photosynthetic carbon flow, including photorespiration, glycolate catabolism, and biosynthesis of nucleotides and isoprenoids, suggesting a cluster of chloroplast-focused metabolic functions. A couple of terms (retina development, IL-4 response) may be annotation noise or cross-annotations, but the dominant signal is photosynthesis-associated metabolism.","confidence":"Medium","size":14,"edges":13,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":10},{"id":"GO:0046296","count":9},{"id":"GO:0009854","count":9},{"id":"GO:0097054","count":9},{"id":"GO:0006144","count":9}]},{"hash":"176997275445418700","title":"Mitochondrial energy and amino acid metabolism","description":"This cluster centers on mitochondrial functions (mitochondrial ATP synthase complex assembly) and amino acid metabolism, with multiple terms for biosynthesis and catabolism of valine, leucine, isoleucine, and D-amino acids; additional terms for cholesterol and folic acid biosynthesis suggest broader metabolic roles within mitochondria.","confidence":"Medium","size":14,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033615","count":2},{"id":"GO:0008203","count":2},{"id":"GO:0019478","count":1},{"id":"GO:0009099","count":1},{"id":"GO:0006550","count":1}]},{"hash":"767225144184448280","title":"Neuronal Signaling and Synaptic Plasticity","description":"The cluster is dominated by terms related to neuronal communication and plasticity: calcium- and activity-dependent neurotransmitter release, vesicle fusion at presynaptic terminals, short- and long-term synaptic changes, memory formation, and neuronal outgrowth (axonogenesis). While there are a few peripheral signaling terms (histamine and insulin secretion), the core pattern points to neural signaling and synaptic modulation.","confidence":"High","size":14,"edges":23,"triangles":5,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0031629","count":4},{"id":"GO:0006351","count":3},{"id":"GO:1990926","count":3},{"id":"GO:0007616","count":3}]},{"hash":"1722629173418067682","title":"Transmembrane metabolite and cofactor transporters","description":"The proteins cluster around numerous transmembrane transport GO terms for a variety of metabolites and cofactors (e.g., fatty acids, deoxynucleotides, phosphate, heme, thiamine pyrophosphate, pyridoxal phosphate) and include several mitochondrial transport terms, indicating a shared role in moving diverse small molecules across membranes. A single insulin-like growth factor\u2013related response term is noted, but the dominant signal is transport activity of cofactors and metabolites across membranes.","confidence":"High","size":14,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":8},{"id":"GO:0031921","count":8},{"id":"GO:0000066","count":8},{"id":"GO:0030302","count":8},{"id":"GO:0030974","count":8}]},{"hash":"618828334183022806","title":"Programmed cell death and innate immunity","description":"The top terms cluster around apoptosis and pyroptosis, with ubiquitination indicating regulation, alongside innate immune response, pointing to a theme of programmed cell death as part of innate immunity; minor terms like mitotic spindle assembly and plasmid maintenance are less central.","confidence":"High","size":14,"edges":21,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":14},{"id":"GO:0070269","count":14},{"id":"GO:0016567","count":14},{"id":"GO:1990001","count":14},{"id":"GO:0045087","count":14}]},{"hash":"1479326952115349403","title":"GABAergic signaling and actin remodeling in neurons","description":"This cluster is enriched for neuronal signaling terms (GABAergic synaptic transmission and dopamine receptor signaling) together with cytoskeletal dynamics (filopodium assembly, regulation by small GTPases, and cell spreading), suggesting a cohesive theme of synaptic signaling linked to actin-based structural remodeling. Mitochondrial fission and ubiquitination regulation further relate to neuronal homeostasis and protein turnover in neurons. Confidence: High","confidence":"","size":14,"edges":13,"triangles":1,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045792","count":7},{"id":"GO:0051489","count":7},{"id":"GO:0051932","count":7},{"id":"GO:0033138","count":7},{"id":"GO:0046847","count":7}]},{"hash":"896672087852135229","title":"T cell activation and raft-associated immune signaling","description":"These terms point to immune activation and signaling: IL-2 production and T cell polarity are classic T cell functions; TLR3 signaling and adhesion molecule production indicate coordinated innate\u2013adaptive responses; lipid localization and raft-associated protein localization emphasize membrane microdomain signaling. The combination suggests a cluster of proteins involved in T cell\u2013mediated immune signaling at membrane rafts, with accompanying lipid metabolism and remodeling.","confidence":"Medium","size":14,"edges":17,"triangles":14,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":3},{"id":"GO:0010876","count":3},{"id":"GO:0032623","count":3},{"id":"GO:0034141","count":3},{"id":"GO:0060355","count":3}]},{"hash":"2273258890970391867","title":"Ubiquitin-Dependent Immune Signaling","description":"The cluster includes ubiquitination-related terms (K48-linked ubiquitination, ERAD) alongside immune signaling pathways (RIG-I, NF-\u03baB, TNF) and general immune responses (innate and adaptive). This suggests a cohesive role in tagging substrates for degradation and modulating immune signaling processes.","confidence":"High","size":14,"edges":37,"triangles":26,"max_degree":10,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0001302","count":3},{"id":"GO:0039536","count":3},{"id":"GO:0070936","count":3},{"id":"GO:0009048","count":3}]},{"hash":"2216526183365324338","title":"Immune Surveillance and Cell-Cell Adhesion","description":"The top GO terms point to immune functions (innate immune response, detection of tumor cells, susceptibility to T cell\u2013mediated cytotoxicity, regulation of macrophage activation, IL-4 production) along with cell\u2013cell adhesion and junction localization. This suggests a cluster of proteins involved in immune surveillance and intercellular communication, though a few terms (lens morphogenesis, spermatid development) appear as outliers. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060370","count":6},{"id":"GO:0043031","count":6},{"id":"GO:0007286","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0002355","count":6}]},{"hash":"1266768874874316896","title":"Calcium- and GPCR-Mediated Signaling","description":"The top GO terms cluster around calcium release into the cytosol and GPCR-activated signaling (including adenylate cyclase pathways), indicating a core theme of calcium- and GPCR-driven signal transduction. Additional terms related to sensory and metabolic responses (temperature, thermogenesis, phototransduction) and vascular/developmental processes (blood pressure, nipple morphogenesis) fit within broad signaling roles that utilize calcium dynamics and GPCR pathways, suggesting this cluster centers on signaling modules rather than a single precise process.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":13},{"id":"GO:0002024","count":13},{"id":"GO:0019233","count":13},{"id":"GO:0051209","count":13},{"id":"GO:0060658","count":12}]},{"hash":"289136153727307669","title":"Innate immune signaling and leukocyte trafficking","description":"The cluster contains multiple innate immune and leukocyte migration-related terms (complement activation via lectin pathway, Fc-gamma receptor signaling, stimulatory C-type lectin receptor signaling, leukocyte tethering/rolling, NK cell chemotaxis regulation, platelet activation) plus lymph vessel morphogenesis, suggesting a theme of immune signaling coupled with vascular/lymphatic interaction. An outlier kidney-development term appears but does not redefine the core theme. ","confidence":"Medium","size":14,"edges":70,"triangles":165,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":13},{"id":"GO:0072218","count":12},{"id":"GO:2000502","count":12},{"id":"GO:0050901","count":12},{"id":"GO:0038094","count":12}]},{"hash":"1304230397598181803","title":"Golgi-Associated Vesicle Trafficking","description":"The predominant GO terms center on Golgi organization, Golgi localization, and vesicle transport (ER-to-Golgi, intra-Golgi, and general vesicle trafficking including endocytosis and synaptic vesicle movement), suggesting a cohesive cluster of proteins involved in Golgi function and vesicle trafficking; a few terms like pigmentation or dsRNA transport appear incidental.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007030","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0033227","count":1},{"id":"GO:0006891","count":1},{"id":"GO:0048313","count":1}]},{"hash":"1185482273633946563","title":"Adhesion signaling in development and immunity","description":"This cluster centers on cell adhesion and integrin-mediated adhesion, coupled with ERK signaling and processes like angiogenesis and synapse assembly, and it also includes immune signaling terms (innate immune response, B cell receptor signaling) and host\u2013symbiont interaction. Together, these terms point to a module where adhesion molecules drive signaling roles across development and immune contexts, justifying a label focused on adhesion and signaling in development and immunity.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010811","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0050853","count":3}]},{"hash":"537021404399796355","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"The cluster is dominated by innate immune and antiviral defense terms, including NF-kappaB-inducing kinase activation, and several ubiquitination-related processes (autoubiquitination, K6-linked ubiquitination, and ubiquitin-dependent protein catabolic processes), suggesting a cohesive module where ubiquitination regulates innate immune signaling and transcriptional responses; a few histone modification terms may reflect chromatin-level regulation of immune genes.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":12},{"id":"GO:0051607","count":12},{"id":"GO:0051865","count":12},{"id":"GO:0090073","count":12},{"id":"GO:0036205","count":12}]},{"hash":"2019814111044698863","title":"Unknown","description":"The terms span immune response, platelet activation, apoptosis, development (brain and gonad), locomotion and behavior, neural signaling, and membrane repair, with no single coherent function tying all proteins together.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0010572","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0008344","count":2}]},{"hash":"2163703392674322260","title":"Antiviral innate immunity and ubiquitin proteostasis","description":"The cluster is enriched for antiviral defense and innate immune response terms, with strong links to ubiquitin-dependent proteolysis/ERAD, suggesting a theme of antiviral defense coupled to protein turnover. Additional terms point to cytoskeletal roles and vesicle trafficking that support immune signaling, along with spleen development and T cell homeostasis that align with immune system context.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051607","count":12},{"id":"GO:0045087","count":12},{"id":"GO:0042787","count":11},{"id":"GO:0030433","count":11},{"id":"GO:0035372","count":10}]},{"hash":"1043060802044168185","title":"Neural Development and Synaptic Localization","description":"The proteins cluster around neural development and synaptic localization functions, with terms like CNS projection neuron axonogenesis, protein localization to synapse, and related neuronal differentiation. While there are outliers related to immune activation, apoptosis, and metabolism, the strongest signal ties to neural connectivity and synaptic targeting, suggesting these proteins participate in forming and wiring neural circuits.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035418","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0010765","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0097194","count":3}]},{"hash":"112428884046561164","title":"Unknown","description":"There is no unifying function among the GO terms; they cover oxidative stress response, apoptosis, immune differentiation, and various developmental processes across species, so a single coherent label cannot be assigned.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071447","count":2},{"id":"GO:0071550","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0001892","count":2},{"id":"GO:0035773","count":1}]},{"hash":"1350518403735841644","title":"Epidermal proliferation and stress response","description":"The GO terms point to cell division (mitotic cell cycle, spindle checkpoint) alongside keratinocyte differentiation and angiogenesis, with additional stress-related responses (toxins, cadmium) and metabolic signaling (glucose). This combination suggests processes typical of epidermal tissue where proliferation and differentiation coordinate with stress adaptation and vascular support, i.e., skin epidermal growth and stress response.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007094","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0030216","count":2}]},{"hash":"2132738125064630849","title":"Bacterial cell wall and envelope biosynthesis","description":"The top terms cluster around cell wall organization, regulation of cell shape, and cell morphogenesis, together with biosynthetic processes for peptidoglycan and lipid A, and GDP-mannose\u2013dependent polysaccharide pathways. This points to a coherent theme of envelope construction and cell-shape maintenance in bacteria, with a notable touch of antibiotic response signals.","confidence":"High","size":13,"edges":60,"triangles":158,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":4},{"id":"GO:0008360","count":4},{"id":"GO:0000902","count":4},{"id":"GO:0009298","count":4},{"id":"GO:0009245","count":4}]},{"hash":"167264880826721630","title":"Retroviral DNA integration and latency","description":"The cluster is dominated by GO terms tied to retroviral life-cycle steps: DNA replication/recombination, DNA integration, RNA-templated DNA biosynthesis (reverse transcription), and establishment of integrated proviral latency, plus viral penetration into the host nucleus. These collectively point to retroviral genome integration and latency as the central theme, with some related virus-host interaction signals (and related intracellular symbiont entries) contributing context. ","confidence":"High","size":13,"edges":76,"triangles":265,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":8},{"id":"GO:0006260","count":6},{"id":"GO:0042493","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0075732","count":4}]},{"hash":"862789846638110565","title":"Fatty acid biosynthesis and lipid metabolism","description":"The GO terms are dominated by fatty acid biosynthetic processes (medium-chain and short-chain), fatty acid elongation, and acetyl-CoA catabolic processes, with additional context from adipose and liver development and starvation response, all pointing to lipid metabolism as the unifying theme. Some outliers (antibiotic biosynthesis, sporulation) exist but do not override the lipid-centric pattern.","confidence":"High","size":13,"edges":42,"triangles":72,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0051792","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0051790","count":7},{"id":"GO:0019367","count":7},{"id":"GO:0060612","count":4}]},{"hash":"1574658143813897851","title":"Cell Adhesion and Trafficking Regulators","description":"This cluster centers on proteins that regulate how cells adhere and manage intracellular trafficking, as evidenced by terms such as positive regulation of substrate adhesion-dependent cell spreading, protein localization to the Golgi, and endocytosis, along with related processes like organelle inheritance. Additional terms point to growth-related roles (osteoblast proliferation, muscle satellite cell migration) and broader regulatory context (ER stress response, steroid hormone signaling), suggesting a core theme of regulation of adhesion and intracellular trafficking with ancillary growth and stress-related functions.","confidence":"Medium","size":13,"edges":38,"triangles":46,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033144","count":6},{"id":"GO:1900026","count":6},{"id":"GO:0000001","count":6},{"id":"GO:1902236","count":5},{"id":"GO:0006897","count":5}]},{"hash":"796916856684046303","title":"Neural signaling and locomotion machinery","description":"This cluster is enriched for nervous-system related processes: grooming and walking behaviors, GABA secretion, neurotransmitter-gated ion channel clustering, and regulation of calcium and potassium channel activity. The presence of muscle development and adherens junction localization hints at neuromuscular coordination components, suggesting proteins that participate in neural signaling and its execution in movement.","confidence":"High","size":13,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2000821","count":2},{"id":"GO:1901843","count":2},{"id":"GO:0048747","count":2},{"id":"GO:0072578","count":2},{"id":"GO:0071896","count":2}]},{"hash":"164319442976073229","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":12,"triangles":3,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0070870","count":3},{"id":"GO:0006306","count":3}]},{"hash":"1878250215963397430","title":"Neural pain signaling and neuroinflammation","description":"This cluster is dominated by neural and pain-related terms: sensory perception of pain, morphine response, and dopaminergic/GABAergic synaptic transmission, pointing to brain-based signaling and pain modulation. Additional terms on prostaglandin response and macrophage chemotaxis suggest inflammatory context, while thermogenesis and brain RAS indicate metabolic/neuroendocrine involvement. An outlier term on viral release may be incidental. Overall, the theme best fits neural pain signaling with inflammatory modulation.","confidence":"Medium","size":13,"edges":25,"triangles":13,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0071502","count":11},{"id":"GO:0002024","count":11},{"id":"GO:0019076","count":10},{"id":"GO:0043278","count":10}]},{"hash":"1829551617767882132","title":"Splicing and translation initiation regulation","description":"The top GO terms cluster around RNA processing and post-transcriptional control: cis-splicing via the spliceosome, splice site recognition, mRNA export, mRNA modification, and regulation of translation initiation, including reinitiation and mRNA stability in response to stress. This pattern indicates a shared role in coordinating splicing with translation onset and mRNA fate.","confidence":"High","size":13,"edges":47,"triangles":86,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0002188","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0016556","count":8},{"id":"GO:1901407","count":8}]},{"hash":"671900372401375426","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":67,"triangles":194,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":11},{"id":"GO:0071630","count":8},{"id":"GO:0034975","count":8},{"id":"GO:0006458","count":8},{"id":"GO:0035719","count":8}]},{"hash":"1354613025865499416","title":"Neural development and cell adhesion","description":"The top GO terms point to neural development processes\u2014neuron migration, synapse assembly, and myelination\u2014and to cell-cell adhesion, suggesting a protein cluster involved in neural tissue formation and connectivity. There are additional developmental terms like angiogenesis and organ identity, but the core signal centers on neural development and adhesion.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0043031","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0001764","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0001525","count":3}]},{"hash":"855239814749781235","title":"Calcium signaling in development and immune regulation","description":"This cluster centers on calcium-related processes (store-operated calcium channel activity, calcium ion transport, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process) that underlie egg activation and general signaling, with developmental themes (positive regulation of myoblast differentiation, angioblast migration, glomerulus development) and immune modulation (interleukin-1-mediated signaling pathway, interleukin-12 production). The shared thread is Ca2+-driven signaling coordinating differentiation, vascular development, and inflammatory pathways.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070498","count":2},{"id":"GO:0032237","count":2},{"id":"GO:0007343","count":1},{"id":"GO:1902634","count":1},{"id":"GO:0045663","count":1}]},{"hash":"1272530638245654021","title":"Myogenesis and ECM remodeling signaling","description":"The terms cluster around skeletal development, myoblast differentiation, collagen fibril organization, and smooth muscle proliferation, indicating muscle formation and extracellular matrix remodeling. Positive regulation of BMP signaling and ERK cascade supports active myogenesis, with some terms pointing to immune regulation during tissue homeostasis.","confidence":"Medium","size":13,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0030513","count":3},{"id":"GO:0048661","count":3},{"id":"GO:0030199","count":2}]},{"hash":"1604167795725322834","title":"Retina and photoreceptor development","description":"The top GO terms center on retina/photoreceptor processes (localization to photoreceptor outer segment, photoreceptor maintenance, retina development in camera-type eye), with additional morphogenesis terms for other tissues, suggesting a developmental theme with retina emphasis.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0006469","count":2},{"id":"GO:0008277","count":2},{"id":"GO:1903546","count":2},{"id":"GO:0045494","count":2}]},{"hash":"2021722833511336970","title":"Developmental morphogenesis","description":"The GO terms cluster around tissue and organ shaping across systems (neuronal axon guidance and signaling, uterine epithelium development, nephric duct elongation, plant ovule morphogenesis) and include cytoskeletal regulation and endocytic recycling, all of which contribute to morphogenesis and development. While terms span multiple organisms, the common theme is growth and structural organization during development, supporting this label. ","confidence":"Medium","size":13,"edges":48,"triangles":73,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":7},{"id":"GO:0035847","count":5},{"id":"GO:0030835","count":5},{"id":"GO:0090334","count":5},{"id":"GO:0032458","count":5}]},{"hash":"903805063380302156","title":"Endothelial Angiogenesis and Vascular Remodeling","description":"Based on the prominent terms for endothelial cell chemotaxis, positive regulation of angiogenesis, and blood vessel morphogenesis, the cluster appears centered on endothelial-driven vascular development and remodeling. Additional signals for fibrinolysis/plasminogen activation and complement activation point to coagulation-immune interactions during vascular remodeling. Some transcription-related terms are present but do not define the core theme. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0045766","count":5},{"id":"GO:1902262","count":4},{"id":"GO:0031639","count":4}]},{"hash":"984170469160434530","title":"Embryogenesis and reproductive organ development","description":"The enriched GO terms point to developmental processes, especially embryonic development and formation of reproductive systems (placenta development, male and female gonad development, in utero embryonic development). The presence of heart/vascular fate and neuron maturation hints at broad organogenesis, while immune-related terms (LPS response, TNF regulation) suggest additional roles in signaling during development. Overall, the cluster seems best described as embryogenesis with emphasis on reproductive and organogenesis processes.","confidence":"Medium","size":13,"edges":51,"triangles":94,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000195","count":13},{"id":"GO:1905695","count":13},{"id":"GO:0001890","count":13},{"id":"GO:0042551","count":13},{"id":"GO:0071222","count":13}]},{"hash":"1891225171880005388","title":"Neural development and glial activation","description":"The proteins show a clear pattern of nervous system development and glial signaling, highlighted by astrocyte activation, Schwann cell development, and axonogenesis, suggesting roles in nerve formation and glial function. Some terms (e.g., polysaccharide catabolic process) are less aligned, but the dominant theme is neural development and glial activation.","confidence":"High","size":13,"edges":40,"triangles":44,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1905205","count":8},{"id":"GO:0033173","count":8},{"id":"GO:0048143","count":8},{"id":"GO:0000742","count":8},{"id":"GO:0007409","count":8}]},{"hash":"2030163989609547057","title":"Steroid and retinoid pigment biosynthesis","description":"The top GO terms cluster around biosynthetic and metabolic processes for steroids (testosterone biosynthesis, glucocorticoid biosynthesis, androgen catabolic) and retinoid/pigment pathways (retinal/retinol metabolism, melanin biosynthesis), suggesting a cohesive theme of lipid-derived metabolite and pigment production. Some outlier terms (sporulation, obsolete oxidation-reduction) are less coherent with the main theme, but the dominant signal points to steroid and retinoid/pigment biosynthesis. ","confidence":"Medium","size":13,"edges":27,"triangles":28,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042574","count":9},{"id":"GO:0061370","count":9},{"id":"GO:0030435","count":9},{"id":"GO:0055114","count":9},{"id":"GO:0017000","count":9}]},{"hash":"149392126933760298","title":"Innate Immune Signaling and Inflammation","description":"The proteins are tied to an innate immune activation program, highlighted by TLR4 signaling, inflammatory response, chemokine production, nitric oxide synthesis, dsRNA sensing, and defense against bacteria, with links to NF-kappaB/JNK pathways and immunoglobulin-mediated responses. This suggests a cohesive immune-response cluster rather than a metabolic or structural module.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0034142","count":4},{"id":"GO:0045429","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0090197","count":4}]},{"hash":"256288926769150312","title":"Developmental cytoskeletal dynamics","description":"The proteins show enrichment for development-related terms (skin development, multicellular organism development) and strong signals for cytoskeletal remodeling (Arp2/3-mediated actin nucleation, mitotic spindle assembly, GTPase regulation). This suggests a theme of actin/microtubule dynamics coordinating development and cell division, with additional expression-related terms (mRNA transport, translation initiation) that may reflect gene regulation during development. Confidence: Medium","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043588","count":6},{"id":"GO:0071456","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0031954","count":4}]},{"hash":"1146258043954810199","title":"Endothelial Activation and Angiogenesis Signaling","description":"The terms cluster around endothelial activation, vascular morphogenesis, and cell migration, with supporting calcium/NFAT signaling and GPCR/PKC pathway involvement, all characteristic of endothelial-driven angiogenesis. Some outliers (SA node regulation, chromatin/chromatin binding) exist but do not override the core vascular/angiogenic theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0098907","count":3},{"id":"GO:0016477","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0042118","count":2}]},{"hash":"323462654997173224","title":"Golgi trafficking and cytoskeleton dynamics","description":"This cluster centers on GO terms for Golgi organization, retrograde transport from Golgi to ER, and tubulin complex assembly, all pointing to vesicle trafficking and cytoskeletal function. Additional terms like autophagosome assembly regulation and cellular response to mechanical stimulus reinforce a theme of intracellular transport and cytoskeletal remodeling that underlie trafficking processes. Developmental terms (hippocampus/kidney development) are broad annotations that can appear in many clusters and are less indicative of the core mechanism here, so the main signal is Golgi- and cytoskeleton-associated trafficking.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032707","count":3},{"id":"GO:0007224","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0007030","count":3},{"id":"GO:0046330","count":3}]},{"hash":"1288529075243019973","title":"Glycan biosynthesis and cell-surface modification","description":"The top GO terms cluster around glycan and glycoprotein processing (poly-N-acetyllactosamine biosynthesis, arabinogalactan protein metabolism, Lewis a epitope biosynthesis, hydroxyproline O-glycosylation), mucilage/seed coat components, and cell-surface or extracellular matrix-related development (root hair, insect eye primordium), suggesting a theme of glycan biosynthesis and cell-surface modification across diverse organisms.","confidence":"Medium","size":13,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001744","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0007299","count":4},{"id":"GO:0075015","count":4},{"id":"GO:0030311","count":3}]},{"hash":"1050224683266073096","title":"Neural development and axon guidance","description":"The GO terms are dominated by nervous system development, hippocampus development, and axonogenesis, with signaling pathways (Roundabout, Smoothened) and cytoskeleton remodeling, suggesting a cohort of proteins linked to neurite outgrowth and guidance rather than cell division. Some mitotic terms appear but likely reflect shared components; overall, the cluster centers on neural development and axon guidance.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0035385","count":3},{"id":"GO:0050771","count":3}]},{"hash":"858555372292410649","title":"Rho GTPase signaling and adhesion","description":"Top terms cluster around regulation of Rho protein signal transduction and GTPase activity, with related signals for PI3K/PLC pathways, cell adhesion, heart development, KIT signaling, and neural plasticity. This suggests a group of proteins linked by broader signal transduction and cytoskeletal/adhesion roles in development and tissue function, hence the label.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0032959","count":2},{"id":"GO:0007155","count":2}]},{"hash":"1856012046144536076","title":"Developmental morphogenesis and tissue regeneration","description":"This cluster centers on tissue and organ development (heart looping, septum morphogenesis, cloaca and hair follicle development) and regenerative processes (wound healing, stem cell division), with supporting growth and mechanotransduction signals, suggesting a unifying theme of development and tissue repair.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0048103","count":2},{"id":"GO:0001947","count":2},{"id":"GO:0042060","count":2},{"id":"GO:0003149","count":2}]},{"hash":"1774485118590433864","title":"Developmental angiogenesis and immune signaling","description":"The Top Terms include angiogenesis, endothelial migration, adaptive immune response, and developmental signaling pathways (Wnt/PCP, ERK, PKC), plus heart-related signaling and cartilage condensation. This points to a developmental program coordinating vascular formation and immune function, with transcriptional regulation involved. Therefore, the label captures the core theme of vascular-immune development in a developmental context.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0001502","count":8},{"id":"GO:0043536","count":7},{"id":"GO:0002250","count":7},{"id":"GO:0001525","count":7}]},{"hash":"1590958077365555417","title":"Autonomic Nervous System Signaling and Ion Transport","description":"Label reflects neural and autonomic signaling influencing physiological functions, driven by catecholamine-mediated effects (vasoconstriction, heart rate regulation), calcium release, and thermogenesis. It also encompasses enteric nervous system development and transepithelial chloride transport, suggesting coordinated neural control of organ function and ion balance; a couple terms (nipple morphogenesis, operant conditioning) are less directly connected and may reflect broader annotations.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051281","count":8},{"id":"GO:0060658","count":7},{"id":"GO:0035106","count":7},{"id":"GO:0035815","count":7},{"id":"GO:0001994","count":7}]},{"hash":"2100441935359492409","title":"ECM organization and connective tissue development","description":"This cluster centers on extracellular matrix remodeling and connective tissue formation, highlighted by collagen fibril organization, basement membrane development, cell-matrix adhesion, cartilage condensation, and broader developmental terms. The presence of angiogenesis-related terms fits tissue morphogenesis contexts, reinforcing a theme around ECM-driven connective tissue and cartilage development during embryogenesis.","confidence":"High","size":13,"edges":17,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":4},{"id":"GO:0001867","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0032836","count":2},{"id":"GO:0007160","count":2}]},{"hash":"1565421536290946661","title":"Myelin regulation and lipid biosynthesis","description":"The cluster shows links to myelin biology, with terms like negative regulation of myelination and CNS myelin maintenance, suggesting a neural/myelin-themed function. Supporting this, several terms involve lipid metabolism and membrane components (unsaturated fatty acid biosynthesis, ergosterol biosynthesis regulation, and mannosyl-inositol phosphorylceramide metabolism), which are relevant to myelin membrane composition. However, several outlier terms (nitrate assimilation, mitochondrion inheritance, sebaceous gland differentiation) indicate the set is not exclusively tied to myelin or lipid pathways. Overall, the most coherent theme is neural myelin regulation intertwined with lipid biosynthesis, but the link is not uniformly strong across all terms.","confidence":"Low","size":13,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031642","count":2},{"id":"GO:0006809","count":1},{"id":"GO:0006636","count":1},{"id":"GO:0006675","count":1},{"id":"GO:0042128","count":1}]},{"hash":"529423411717061745","title":"Immune and tissue remodeling","description":"The top GO terms span collagen fibril organization (ECM), complement activation, endothelial cell migration, macrophage signaling, adaptive immune response, apoptotic cell recognition, and neural remodeling at the NMJ, plus synaptic transmission. This pattern suggests a cluster of proteins involved in inflammation-associated tissue remodeling across extracellular matrix, vasculature, immune system, and nervous system, rather than a single, narrow function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":7},{"id":"GO:0001867","count":6},{"id":"GO:0014814","count":6},{"id":"GO:0090331","count":6},{"id":"GO:0043654","count":6}]},{"hash":"664308769209968207","title":"Diverse Transmembrane Transporters","description":"The top GO terms point to broad membrane transport activities across ions and various metabolites, including neurotransmitter loading into synaptic vesicles, sialic acid, urate, arabinose, 4-hydroxyphenylacetate, phosphate, and vitamin transport, plus general responses to nutrient status. This pattern strongly suggests a cluster of transmembrane transporter proteins handling diverse substrates, including vesicular transporters for neurotransmitters. ","confidence":"High","size":13,"edges":71,"triangles":214,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":13},{"id":"GO:0015739","count":13},{"id":"GO:0015747","count":13},{"id":"GO:0015751","count":13},{"id":"GO:1900754","count":13}]},{"hash":"2124715621110129722","title":"Developmental gene regulation and chromatin modification","description":"These proteins appear to be involved in fundamental gene expression control (mRNA splicing, transcription) and chromatin state (histone methylation), with GO terms spanning various developmental processes (placenta, pancreas, cartilage, left-right patterning, endocrine system development). This suggests a cohesive theme of regulating gene expression during development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0034729","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0060707","count":2}]},{"hash":"209285381211327806","title":"Membrane trafficking and signaling proteins","description":"The GO terms point to membrane-associated processes and signaling: maintenance of protein localization in the plasma membrane, regulation of SNARE complex assembly (vesicle fusion), and broader signaling pathways (NOD2, salicylic acid signaling) along with multicellular organismal processes and nervous system development. These collectively suggest a cluster of proteins involved in membrane trafficking and signaling rather than a single tightly cohesive pathway, hence a Membrane trafficking and signaling proteins label. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:1900827","count":2},{"id":"GO:0046475","count":2},{"id":"GO:2000031","count":2},{"id":"GO:0090501","count":2}]},{"hash":"2137010051231615323","title":"Neuroimmune development and synapse formation","description":"The cluster links neural development processes (axonal fasciculation, myelination, synapse assembly) with immune-related pathways (complement activation, innate immune response), suggesting proteins that participate in neuron-immune signaling and regulation of synapse formation. Signaling terms like ERK/MAPK and PI3K are present, supporting cross-talk between developmental and immune signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":8},{"id":"GO:0042552","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0007157","count":6}]},{"hash":"173459082112811777","title":"Neuronal signaling and sensory circuits","description":"Label reflects a cluster of proteins involved in neural signaling and sensory integration. Several terms point to synaptic transmission (GABA receptor clustering; acetylcholine receptor signaling; dopamine secretion), neural innervation, and rapid behavioral responses (startle). Ion transport terms (calcium and sodium import/transport) support neuronal excitability, while LGN development and circadian/sleep regulation suggest involvement in sensory processing and arousal. Overall, this cluster represents neuronal signaling in sensory networks and circadian/arousal regulation.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":10},{"id":"GO:0001964","count":10},{"id":"GO:0045188","count":10},{"id":"GO:0021771","count":9},{"id":"GO:0097112","count":9}]},{"hash":"1956049308357902533","title":"RNA processing and translation regulation","description":"The GO terms cluster around post-transcriptional gene expression: splicing via the spliceosome, ncRNA-mediated gene silencing, mRNA export, mRNA modification, regulation of mRNA stability in stress, and various aspects of translation initiation and preinitiation complex formation. This pattern suggests the proteins cooperate to control mRNA maturation and translation, rather than a single pathway.","confidence":"High","size":12,"edges":34,"triangles":52,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":9},{"id":"GO:0031047","count":9},{"id":"GO:1901407","count":7},{"id":"GO:0010610","count":7},{"id":"GO:0002188","count":6}]},{"hash":"1555370752456834904","title":"Signaling Regulation and Trafficking","description":"This cluster centers on proteins involved in diverse signaling pathways (PKC activation, TGF-beta signaling, Fc receptor signaling, angiotensin signaling) and processes related to cargo transport and cytoskeletal remodeling (COPII vesicle loading, lamellipodium formation), plus ER stress modulation and immune activation, suggesting a broad theme of coordinated signaling and trafficking rather than a single specific function.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045737","count":5},{"id":"GO:2000394","count":5},{"id":"GO:0090110","count":4},{"id":"GO:0086098","count":4},{"id":"GO:1990051","count":4}]},{"hash":"1530854871003866334","title":"Diverse Metabolite Biosynthesis","description":"The top GO terms point to biosynthetic processes for a range of metabolites (cobalamin, heme, biotin, sphinganine, alanine, oxaloacetate) and related metabolic activities, with an additional transcription-related term. This suggests a cluster of proteins involved in diverse biosynthetic pathways rather than a single, unified pathway, justifying a broad \u201cdiverse metabolite biosynthesis\u201d label. ","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0009862","count":2},{"id":"GO:0006523","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006783","count":2}]},{"hash":"543398564334819022","title":"Calcium-Driven Development in Muscle, Nerve, and Vessel","description":"The top GO terms point to calcium signaling (calcium ion detection and the calcineurin-NFAT cascade) coordinating development in several tissues: skeletal muscle fibers, Schwann cells (nerve glia), and blood vessel branching. The presence of neural-related terms (cocaine response) reinforces a neural calcium signaling theme linking muscle, nerve, and vasculature development. This suggests a coherent, calcium-dependent developmental program across these tissues.","confidence":"High","size":12,"edges":61,"triangles":177,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:1905205","count":3},{"id":"GO:0033173","count":3},{"id":"GO:0014044","count":3},{"id":"GO:0005513","count":3}]},{"hash":"367468129767523833","title":"Mitochondrial Electron Transport and Apoptosis","description":"The top GO terms point to mitochondrial respiration (cytochrome c\u2013related electron transport chains), cytochrome c\u2013mediated apoptotic activation, and hydrogen peroxide metabolism/response, indicating a focus on mitochondria-driven ROS signaling and apoptotic pathways. Some terms like photosynthesis or carbons monoxide response may appear due to broad redox-related annotations, but the core pattern centers on mitochondrial respiration connected to apoptosis. ","confidence":"Medium","size":12,"edges":17,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0006123","count":2},{"id":"GO:0010730","count":2},{"id":"GO:0008635","count":2},{"id":"GO:0006470","count":2}]},{"hash":"1957251707693854467","title":"Programmed cell death and innate immune signaling","description":"The cluster is enriched for apoptotic process, pyroptotic inflammatory response, and innate immune response, with ubiquitination and calcineurin-NFAT signaling also represented, suggesting a coherent theme around inflammatory programmed cell death and immune signaling. Some terms like mitotic spindle assembly and polysaccharide catabolic process are present but appear less central to the core theme, so the label focuses on immune-related cell death pathways.","confidence":"High","size":12,"edges":60,"triangles":168,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006915","count":7},{"id":"GO:0070269","count":7},{"id":"GO:0016567","count":7},{"id":"GO:1990001","count":7},{"id":"GO:0045087","count":7}]},{"hash":"326550234160115695","title":"Autonomic Neuroendocrine Regulation","description":"The terms cluster around neural and hormonal control of organ systems: epinephrine/norepinephrine\u2013driven vasoconstriction and heart rate, renal sodium handling, enteric nervous system development, thermogenesis, IP3 signaling, and transepithelial transport. While a few terms touch on broader development or immune signaling, the dominant theme is autonomic/neuroendocrine regulation of cardiovascular, renal, and metabolic functions.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060658","count":12},{"id":"GO:0035106","count":12},{"id":"GO:0035815","count":12},{"id":"GO:0001994","count":12},{"id":"GO:0001996","count":12}]},{"hash":"1524158151807285314","title":"Cardiac Development and Morphogenesis","description":"The top GO terms cluster around heart formation and related morphogenesis: atrium and ventricle formation, outflow tract development, aorta formation, and regulation of heart rate, with supporting signals for heart valve development and associated cardiac neural crest processes. A few terms touch neural differentiation, but the overall theme points to cardiac structural and functional maturation programs during development.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0045663","count":5},{"id":"GO:0061309","count":5},{"id":"GO:0035910","count":5},{"id":"GO:0021892","count":5}]},{"hash":"991239413386518358","title":"Embryonic Neural Development and Signaling","description":"This cluster\u2019s top GO terms point to developmental processes (axial mesoderm formation, myoblast differentiation, ovulation cycle) and neural differentiation/synapse formation (synapse assembly, dendrite development), with supporting roles in cell adhesion and spreading, suggesting proteins involved in embryogenesis and neural development and their signaling. Some terms (chitin catabolic process, T cell costimulation) appear less related, possibly reflecting pleiotropy or species-specific roles. Overall, the core theme appears to be developmental and neural differentiation with accompanying cell-adhesion dynamics.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006032","count":8},{"id":"GO:0045663","count":8},{"id":"GO:0042698","count":8},{"id":"GO:0048320","count":8},{"id":"GO:0051965","count":8}]},{"hash":"980215721229321231","title":"Developmental Signaling Pathways","description":"The top GO terms point to several signaling pathways (T cell receptor signaling, Roundabout, Smoothened) and development-related processes (nervous system development, kidney development). Additional terms about ER-Golgi vesicle transport, cell division and regulation of proliferation suggest coordination between signaling and the cell cycle during organogenesis. Taken together, the cluster seems enriched for signaling modules that guide development and tissue formation across neural and renal contexts, with linked pathways that regulate growth. Therefore, Developmental Signaling Pathways appears as a concise, representative label.","confidence":"Medium","size":12,"edges":40,"triangles":60,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":10},{"id":"GO:0035385","count":9},{"id":"GO:0007224","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0001822","count":9}]},{"hash":"2291678928437851288","title":"Neural development and energy metabolism","description":"This cluster centers on brain development (cerebellum and substantia nigra) and neuronal energy processes (creatine/phosphocreatine metabolism and phosphorylation), with related neural signaling features such as chloride ion homeostasis, implying a cohesive brain development and metabolic function. Confidence: Medium","confidence":"","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0006950","count":2},{"id":"GO:0021549","count":2},{"id":"GO:0016310","count":2}]},{"hash":"1304262831059411619","title":"Neural development and axon guidance","description":"The cluster's top GO terms converge on neural development and axon guidance: Slit-Robo (Roundabout) signaling, Hedgehog signaling (Smoothened), nervous system development, synapse assembly, and axon-axon domain localization, suggesting roles in neuron formation and neural wiring. While angiogenesis and kidney development are also present, the core pattern reflects neuronal connectivity and guidance.","confidence":"High","size":12,"edges":32,"triangles":26,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035385","count":7},{"id":"GO:0001822","count":7},{"id":"GO:0007224","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0045663","count":6}]},{"hash":"516524825133100394","title":"Innate immune activation and apoptosis/pyroptosis regulation","description":"Strong enrichment for innate immune response, apoptosis, and pyroptosis, plus ubiquitination, points to a cluster of proteins involved in innate immune signaling and regulation of inflammatory cell death. Regulatory terms for macrophage and NK cell activity support this theme, while an unrelated term (mitotic spindle assembly) does not define the core function.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":11},{"id":"GO:0006915","count":10},{"id":"GO:0070269","count":10},{"id":"GO:0016567","count":10},{"id":"GO:1990001","count":10}]},{"hash":"99987654625079671","title":"Neural Development and Function","description":"This cluster is clearly centered on nervous system biology: axonogenesis, long-term synaptic potentiation, Schwann cell development, and visual perception dominate the terms, pointing to neural development and synaptic activity. While heart development and angiogenesis appear as additional hints of broader growth programs, the neural terms are the strongest signal. A few outliers (ABA signaling, cell cycle regulation, apoptosis) may reflect cross-functional components or annotation noise but do not overshadow the neural theme.","confidence":"High","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007409","count":6},{"id":"GO:0060291","count":6},{"id":"GO:0014044","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0001525","count":5}]},{"hash":"2270809871082842296","title":"Sterol and lipid biosynthesis","description":"The top GO terms cluster around sterol and lipid metabolism: ergosterol biosynthesis, cholesterol biosynthesis, fatty acid biosynthesis, and ether lipid metabolism. This suggests the proteins collectively participate in lipid/sterol production and processing, with a few terms reflecting related lipid-rich contexts. Overall, the dominant theme is lipid and sterol biosynthesis.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006696","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0046485","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0035754","count":3}]},{"hash":"801788090620792609","title":"Immune Signaling and Apoptosis Regulation","description":"The cluster\u2019s GO terms cluster around signaling pathways (NF-kappaB, Wnt, EGFR, small GTPases) and innate immune response, plus apoptosis, pointing to a common theme of signaling networks governing immune responses and cell fate. A developmental term (labyrinthine layer morphogenesis) suggests broader roles in tissue development, likely via these signaling routes. Confidence: Medium","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045794","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0045087","count":2}]},{"hash":"2056602414212449903","title":"Neural development and glial signaling","description":"The cluster is dominated by terms related to neural and glial biology: astrocyte activation, Schwann cell development, and axonogenesis point to glial support and nerve growth; visual perception aligns with neural tissue (retina). Calcineurin-NFAT signaling is a calcium-dependent pathway also implicated in neural cells. Some terms (karyogamy, polysaccharide catabolic process) seem outliers or general cellular processes, but the core theme centers on neural development and glial signaling.","confidence":"Medium","size":12,"edges":12,"triangles":1,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1905205","count":2},{"id":"GO:0033173","count":2},{"id":"GO:0048143","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0007409","count":2}]},{"hash":"2059927846052089108","title":"Musculoskeletal and craniofacial development","description":"The top GO terms cluster around developmental processes in skeletal, craniofacial, and muscle tissues (skeletal system development, roof of mouth development, muscle cell development). Additional regulatory terms (negative regulation of DNA binding, protein binding, endopeptidase activity) and related cellular processes (ER-Golgi transport, cell division) suggest coordinated control of gene expression and protein processing during tissue formation, supporting a musculoskeletal/craniofacial development theme rather than a single functional pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0043392","count":2},{"id":"GO:0048747","count":2}]},{"hash":"2067307547988838019","title":"Neural development and brain morphogenesis","description":"The top GO terms cluster around brain development, forebrain development, and neural tube closure, with supportive growth and proliferation terms, suggesting a neural-development theme focused on brain formation; a few terms related to translation initiation and defense response appear ancillary or reflective of general cellular processes in development.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0001843","count":3}]},{"hash":"1504457279046486107","title":"Head and neural development","description":"The top GO terms highlight developmental processes of the head and nervous system (forebrain morphogenesis, eye development, cranial skeletal system development) along with neural signaling terms (MAP kinase regulation). Although other terms touch on immune or detoxification processes, the strongest shared theme among the terms is development of neural/head structures and sensory organs, which justifies this label as representative of the cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043407","count":2},{"id":"GO:0048853","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0051044","count":2},{"id":"GO:0051092","count":2}]},{"hash":"2214891816565237425","title":"Inflammation-driven angiogenesis and vascular remodeling","description":"The cluster is enriched for angiogenesis, endothelial cell migration, and cell-matrix adhesion, alongside immune-related processes (adaptive immune response, complement activation) and coagulation, suggesting a module coordinating vascular remodeling during inflammation and immune responses. ERK signaling appears as a shared regulatory pathway, though the presence of a neuronal synaptic term likely reflects common signaling machinery rather than a neural function. Overall, the theme centers on inflammation-associated blood vessel growth and coagulation.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070374","count":10},{"id":"GO:0051968","count":9},{"id":"GO:0043536","count":9},{"id":"GO:0002250","count":9},{"id":"GO:0001525","count":9}]},{"hash":"189165177238520083","title":"BMP/TGF-\u03b2 signaling and EMT in morphogenesis","description":"This cluster centers on BMP signaling, TGF-\u03b2\u2013responsive pathways, and epithelial-to-mesenchymal transition (EMT) with links to organ morphogenesis and regulated cell adhesion. While a couple terms touch insect cuticle formation or balance perception, the dominant theme is signaling-driven development and tissue remodeling. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0033628","count":1},{"id":"GO:0035293","count":1},{"id":"GO:0008101","count":1},{"id":"GO:0071560","count":1}]},{"hash":"1505881890361790246","title":"Diverse plasma membrane solute transporters","description":"Top GO terms indicate multiple transmembrane transport activities across the plasma membrane for various substrates (myo-inositol, glucose, biotin, pantothenate, amino acids, pyruvate) and for ion export (sodium, calcium). This pattern suggests the proteins function primarily as solute transporters rather than as a single complex, supporting a label centered on membrane transport across diverse substrates. The acetylcholine biosynthetic process term appears peripheral and does not change the primary transport theme. Overall, the cluster seems to group diverse transmembrane transporters at the plasma membrane.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015878","count":2},{"id":"GO:0015887","count":2}]},{"hash":"470265333661248740","title":"Neuronal development and neurotrophin signaling","description":"Top GO terms center on nervous system development (including cerebellum development) and neurotrophin TRK receptor signaling, which together point to neuronal growth, differentiation, and survival roles. Additional terms related to anti-apoptotic regulation and neuroprotection (negative regulation of apoptotic signaling) support a neural context. A few terms about cilium assembly and Nebenkern assembly are more peripheral but can be linked to cellular organization in neural or specialized cells. Overall, the cluster appears tied to neural development and neurotrophic signaling, justifying the label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:1902042","count":2},{"id":"GO:2000352","count":2},{"id":"GO:1902857","count":1},{"id":"GO:1902430","count":1}]},{"hash":"869346562675619263","title":"Histone methylation and chromatin silencing","description":"The top GO terms are dominated by histone methylation and heterochromatin-related processes (H3K4, H3K9, H3K27, H4K20 trimethylation and rDNA heterochromatin formation), indicating a cluster of proteins involved in chromatin modification and gene silencing. A few other terms about signaling regulation may reflect secondary roles or annotation artifacts, but the core theme is chromatin-based regulation.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0080182","count":1},{"id":"GO:1900477","count":1},{"id":"GO:0036124","count":1},{"id":"GO:1902231","count":1}]},{"hash":"223316199378485315","title":"Diverse biosynthesis and metabolism","description":"This cluster includes GO terms spanning various biosynthetic and metabolic processes (antibiotic biosynthesis, retinal/melanin/retinol/ testosterone biosynthesis, and general ribosome biogenesis), along with activation of protein kinase activity. The mix suggests a broad involvement in cellular metabolism and biogenesis rather than a single, cohesive pathway, leading to a broad-but-non-specific label.","confidence":"Medium","size":11,"edges":47,"triangles":107,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0032147","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0042574","count":1},{"id":"GO:0061370","count":1}]},{"hash":"711198164544274021","title":"Gene Expression and Mitosis Machinery","description":"These terms cluster around early gene expression (mRNA export, translation initiation/reinitiation) and mitotic/cytoskeletal processes (microtubule severing, CENP-A chromatin assembly), with some protein trafficking (ER-Golgi transport). The common theme appears to be coordination of RNA processing/translation with mitotic machinery.","confidence":"Medium","size":11,"edges":22,"triangles":16,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0051013","count":2}]},{"hash":"148365835456266842","title":"Innate Immune Adhesion and Host Interaction","description":"These proteins cluster around innate immunity and cell-surface interactions: innate immune response, heterophilic cell-cell adhesion, and macrophage activation regulation point to immune signaling at cell interfaces; the symbiont entry into host cell term suggests microbe-host interactions, and adhesion supports cell contacts during immune recognition. While some development-related terms appear (angiogenesis, skeletal system development, planar polarity), they may reflect broader signaling or tissue remodeling roles rather than a single cohesive pathway. Overall, the cluster is best described as innate immune communication and host-cell adhesion.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":8},{"id":"GO:0046718","count":8},{"id":"GO:0032516","count":7},{"id":"GO:0043031","count":5},{"id":"GO:0051965","count":5}]},{"hash":"604996814146916537","title":"Immune Signaling and Transcription Regulation","description":"The dominant terms point to immune-related signaling pathways (lipopolysaccharide response, GM-CSF stimulus, T cell receptor signaling) and downstream transcriptional control (DNA-templated transcription, IL-2 production). Protein autophosphorylation supports kinase-driven signaling, reinforcing a theme of signaling cascades leading to transcriptional changes in immune contexts; the other terms appear as outliers or broader signaling connections (light response, fungal development). Overall, the cluster centers on immune signaling coupled to transcriptional regulation.","confidence":"Medium","size":11,"edges":5,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046777","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0097011","count":5},{"id":"GO:0050852","count":5}]},{"hash":"899485993452002998","title":"Ribosome biogenesis and translational control","description":"Dominant GO terms center on translation and ribosome handling (translation, translational initiation, positive regulation of cytoplasmic translation, translational elongation) and ribosomal small subunit export from the nucleus, with supporting terms for mRNA decay and selenocysteine incorporation. A few stress-related responses (response to xenobiotic stimulus, response to antibiotic) likely reflect translation regulation under external challenges. Confident that the cluster represents translation machinery and its regulation.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":3},{"id":"GO:0000056","count":3},{"id":"GO:0014009","count":3},{"id":"GO:0006413","count":3},{"id":"GO:0001514","count":3}]},{"hash":"1816247558281346515","title":"Angiogenesis- and cytoskeleton-guided cell migration signaling","description":"The GO terms converge on sprouting angiogenesis, ROBO roundabout signaling, actin cytoskeleton polarity, and mechanical stimulus response, indicating a theme of coordinated cytoskeletal remodeling and directional migration during angiogenic sprouting. Negative regulation of migration in sprouting angiogenesis and negative chemotaxis further support guided movement. Some additional terms (oligodendrocyte differentiation, apoA-I signaling) may reflect CNS signaling cross-talk but do not override the central motif. Overall, the cluster appears to reflect signaling networks coordinating angiogenesis with cytoskeleton-driven cell migration.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030950","count":3},{"id":"GO:0048714","count":3},{"id":"GO:0002040","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0038027","count":3}]},{"hash":"1343028148809937505","title":"Synapse organization and spine remodeling","description":"The top GO terms point to actin cytoskeleton organization, dendritic spine maintenance, and regulation of synapse structural plasticity, all central to neuronal synapse architecture and spine remodeling. Rho signaling and JNK cascade regulation further support a theme of cytoskeletal dynamics and signaling in synaptic plasticity; a few terms touch on junction localization or behavior, but the dominant signal is neural synapse structure and spine remodeling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030036","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0097062","count":3},{"id":"GO:0046328","count":3},{"id":"GO:2000821","count":2}]},{"hash":"1420299256560078720","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning immune signaling (IL-3 and GM-CSF production, T cell proliferation, LPS response), cell cycle regulation, and even plant- or non-mammalian-specific processes (pollen recognition, plastid development), plus aging/stress terms and cocaine response. There isn\u2019t a single coherent function or pathway tying all proteins together, so the cluster does not have a clear, unified theme. ","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":5,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":11},{"id":"GO:0045401","count":11},{"id":"GO:0045425","count":11},{"id":"GO:0071222","count":11},{"id":"GO:2000811","count":11}]},{"hash":"479813524669589116","title":"Collagen fibril organization and skeletal development","description":"The top GO terms cluster around extracellular matrix organization and skeletal formation (collagen fibril organization, osteoblast development, embryonic cranial skeleton morphogenesis), suggesting a connective tissue/bone development theme. While additional terms touch on retina development, immune signaling, and coagulation, these appear ancillary to the main ECM/skeletal signal, consistent with a cluster focused on ECM assembly and bone formation. The lack of edges reinforces a broad developmental/structural grouping rather than a single tight pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0002076","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0001867","count":2}]},{"hash":"1969067648804634353","title":"Neural Development and Embryogenesis","description":"This cluster is dominated by neural development terms (neuron projection development, forebrain development, neural tube closure) with additional embryonic development signals (multicellular organism development, skeletal system development). The presence of mitotic cycle and APC-related processes suggests general developmental and proliferative roles, but the strongest signal is neural development, supporting a label focused on neural formation during embryogenesis. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0006349","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0001501","count":4}]},{"hash":"538180334338795472","title":"Brain signaling and sensory perception","description":"Most terms cluster around neural processing and sensory perception, especially vision and somatosensory cues, plus dopaminergic synaptic transmission and cocaine-related behavioral responses. The ERK cascade and GTPase activity terms suggest common neuronal signaling pathways. A few outliers (heart development, macrophage chemotaxis) may reflect shared signaling modules rather than a central neural function. Overall, the cluster appears to capture brain signaling involved in sensory processing and reward-related behavior.","confidence":"Medium","size":11,"edges":29,"triangles":20,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0007601","count":5},{"id":"GO:0010759","count":5},{"id":"GO:0070374","count":5}]},{"hash":"1567708375165607185","title":"Inflammatory cytokine signaling and chemokine regulation","description":"This cluster\u2019s GO terms cluster around immune signaling and chemokine regulation: multiple terms involve regulation or production of chemokines (e.g., CXCL1), IL-1\u2013mediated signaling, and negative regulation of IL-10 and B cell proliferation, pointing to inflammatory cytokine pathways. Additional terms about endothelial barrier establishment and oxidative stress response align with inflammation-related tissue regulation. The pyramidal neuron differentiation term appears indiscrete relative to the core immune theme, suggesting some noise, but the dominant pattern supports inflammation/chemokine signaling roles.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0021859","count":1},{"id":"GO:0030889","count":1},{"id":"GO:2000338","count":1},{"id":"GO:0097296","count":1},{"id":"GO:0045080","count":1}]},{"hash":"1699832178684856275","title":"Intracellular vesicle trafficking and secretory pathway","description":"The top GO terms point to ER-to-Golgi and Golgi-to-ER transport, SRP-dependent Cotranslational targeting to membranes, MVB assembly, and Golgi-to-plasma membrane trafficking, together with negative regulation of exosomal secretion and general protein transport. This pattern indicates a cluster of proteins primarily involved in the secretory/vesicular trafficking system, including ER\u2013Golgi cycling, endosome formation, and exosome-related pathways, with some contribution from membrane-targeting processes. Overall, these terms converge on a coherent theme of intracellular vesicle transport and secretion.","confidence":"High","size":11,"edges":10,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0006360","count":2},{"id":"GO:0006614","count":2},{"id":"GO:0036258","count":2},{"id":"GO:0090316","count":2}]},{"hash":"299405265503195964","title":"Hormone-responsive Metabolic Pathways","description":"This cluster shows frequent associations with hormone signaling and metabolism (response to thyroid hormone, prostaglandin D stimulus, testosterone biosynthesis, bile acid biosynthesis, retinal metabolism) along with related stress responses (hydrogen peroxide, stress-activated kinase signaling) and reproductive processes (maternal pregnancy). The combination suggests proteins centered on endocrine-regulated metabolism and related signaling rather than a single narrow function.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042843","count":11},{"id":"GO:0097066","count":11},{"id":"GO:0031098","count":11},{"id":"GO:0060135","count":11},{"id":"GO:0071799","count":11}]},{"hash":"739804280517734739","title":"Unknown","description":"The top GO terms are a mix of chromatin modification, development, aging, cytoskeleton remodeling, metabolism, and metal/ion responses, many marked obsolete, with no evident shared function or interaction among the proteins. The lack of edges further supports the absence of a coherent, singular theme to label. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016575","count":3},{"id":"GO:0034720","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0007369","count":3},{"id":"GO:0007275","count":3}]},{"hash":"1802509660856649825","title":"Coagulation and immune signaling","description":"This cluster is dominated by GO terms tying coagulation (blood coagulation, fibrin clot formation; platelet aggregation and its regulation) with innate immune responses (complement activation, lectin pathway; cellular response to interleukin-1; apoptotic cell recognition). Additional terms about signaling (receptor tyrosine kinase activation) and injury responses (UV-B exposure, axon regeneration notes) fit into broader stress/injury signaling networks but do not outweigh the core coagulation\u2013immune theme. Confidence: Medium.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0071347","count":4},{"id":"GO:0072378","count":4},{"id":"GO:0071493","count":4},{"id":"GO:0014814","count":4}]},{"hash":"1134360439545577354","title":"Mitochondrial Metabolite Transporters","description":"This cluster is dominated by GO terms for transporting diverse metabolites and cofactors across membranes, especially related to mitochondria (e.g., deoxynucleotides, phosphate, heme, PLP, TPP, fatty acid, and ornithine transport) and includes regulation of mitochondrial membrane potential, suggesting a unifying function in mitochondrial metabolite transport and energetic regulation.","confidence":"Medium","size":11,"edges":16,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051881","count":3},{"id":"GO:0070542","count":2},{"id":"GO:0031921","count":2},{"id":"GO:0000066","count":2},{"id":"GO:0030302","count":2}]},{"hash":"503563066340315319","title":"Inflammation and Innate Immunity with Angiogenesis","description":"The cluster is dominated by terms related to acute and innate immune responses and cytokine regulation (positive regulation of cytokine production in inflammatory response; innate immune response; acute inflammatory response to antigenic stimulus), along with sprouting angiogenesis, implying inflammation-driven vascular remodeling. Lipoprotein transport/clearance points to lipid handling linked to inflammatory states, while developmental terms may reflect shared signaling pathways but are less central. Overall, the group coherently centers on inflammatory signaling and angiogenesis with accompanying lipid metabolism.","confidence":"High","size":11,"edges":16,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1900017","count":5},{"id":"GO:0002040","count":5},{"id":"GO:0034381","count":5},{"id":"GO:0061053","count":5},{"id":"GO:0045087","count":5}]},{"hash":"465635857928356313","title":"Inflammatory Coagulation and Platelet Signaling","description":"The cluster is dominated by GO terms for complement activation (lectin pathway), platelet aggregation and its regulation, blood coagulation, and inflammatory responses (interleukin-1), with supporting signaling and adhesion terms. Together these point to a cohesive set of proteins involved in inflammatory and coagulation cross-talk, especially platelet-driven signaling. Some terms like UV-B response or axon regeneration at the NMJ appear peripheral but do not override the core coagulation-immune theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0071347","count":11},{"id":"GO:0072378","count":11},{"id":"GO:0071493","count":11},{"id":"GO:0014814","count":11}]},{"hash":"2148611166283304548","title":"RNA and protein methylation","description":"The cluster is dominated by methylation-related GO terms, including RNA guanine-N7 methylation (mRNA capping) and rRNA guanine-N7 methylation, as well as several protein methylation terms (N-terminal trimethylation, peptidyl-lysine dimethylation, histone methylation). While other terms (stress responses, metabolite biosynthesis) appear, the consistent theme is methylation/modification by methyltransferases across RNA and proteins.","confidence":"Medium","size":11,"edges":9,"triangles":0,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":8},{"id":"GO:0036265","count":8},{"id":"GO:0001887","count":7},{"id":"GO:0009236","count":7},{"id":"GO:0070476","count":7}]},{"hash":"25590381969059689","title":"TLR-NLR driven antibacterial inflammatory response","description":"The GO terms cluster around LPS and triacyl lipopeptide responses, TLR4 and TLR9 signaling, macrophage cytokine production, neutrophil extravasation, and NLRP3 inflammasome assembly, indicating innate immune activation against bacteria; an outlier term (male gonad development) is likely incidental.","confidence":"High","size":11,"edges":9,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0034162","count":3},{"id":"GO:0070430","count":2},{"id":"GO:0071727","count":2}]},{"hash":"2009821100085349508","title":"Proviral integration and latency","description":"The GO terms cluster around viral genome integration and latency, including DNA recombination, DNA integration, RNA-templated DNA biosynthesis, and viral entry into the host nucleus, indicating proviral integration and retroviral-like genome processing; additional terms on replication and host interaction support this theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0015074","count":3},{"id":"GO:1903704","count":3}]},{"hash":"708665064990629006","title":"ECM adhesion and cartilage morphogenesis","description":"This cluster shows a cohesive theme around cells interacting with and remodeling the extracellular matrix, highlighted by integrin signaling, cell-matrix adhesion, ECM assembly regulation, hyaluronan metabolism, and cartilage morphogenesis in growth plates. Some terms like chloride transport and neural/differentiation aspects are less connected, but the core signal revolves around ECM adhesion and cartilage development.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0006821","count":5},{"id":"GO:1901202","count":4},{"id":"GO:0031104","count":4},{"id":"GO:0035987","count":4}]},{"hash":"2270771884074761400","title":"Modulators of innate immune signaling","description":"The set centers on regulatory GO terms for innate immunity, including negative regulation of IL-6 and IFN-\u03b1 production, and negative regulation of NOD2 and TLR9 pathways, plus related processes like receptor turnover and barrier maintenance. This pattern suggests the proteins mostly fine-tune or dampen immune signaling and inflammatory responses rather than act as core effectors, with some involvement in endothelial barrier function. Confidence: High","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0034165","count":10},{"id":"GO:1900165","count":10},{"id":"GO:1903898","count":10},{"id":"GO:0032687","count":10},{"id":"GO:0090557","count":10}]},{"hash":"1010013135584277507","title":"Apoptosis and innate immune signaling","description":"The top terms cluster around programmed cell death (apoptosis, pyroptosis) and innate immune responses, suggesting a shared theme of cell fate under immune-related stress. Ubiquitination and signaling terms further support regulatory control of these processes, with additional differentiation terms indicating broader developmental roles. Overall, the strongest link ties apoptosis/pyroptosis to innate immunity.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0001501","count":3},{"id":"GO:0050731","count":3}]},{"hash":"994348085672323416","title":"MAPK/ERK signaling in neural and vascular development","description":"These proteins cluster around ERK/MAPK signaling and broad developmental processes, including angiogenesis, heart development, axonogenesis, and synapse assembly, plus VEGF signaling and cell-matrix adhesion. This suggests a coherent theme of MAPK/ERK-driven neural and vascular/heart development.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0007507","count":6},{"id":"GO:0000186","count":5},{"id":"GO:0048010","count":5}]},{"hash":"62926072812626064","title":"Innate Immunity and Vascular Remodeling","description":"The cluster centers on innate immune activity (complement activation, phagolysosome formation, innate immune response) and processes tied to blood vessel formation and stabilization (sprouting angiogenesis, vascular smooth muscle differentiation, cell adhesion). Some terms like sound perception are likely incidental, but the dominant theme is immune-initiated tissue remodeling involving vascular and adhesion processes.","confidence":"Medium","size":11,"edges":35,"triangles":43,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0001845","count":2},{"id":"GO:0090050","count":2},{"id":"GO:0050910","count":2},{"id":"GO:0045087","count":2}]},{"hash":"105112570954704092","title":"Autonomic nervous signaling and cardiovascular regulation","description":"Most terms point to neural/adrenergic signaling and autonomic control of cardiovascular and metabolic functions (ERK signaling downstream of G-protein pathways; norepinephrine/epinephrine\u2013mediated vasoconstriction and heart-rate regulation; thermogenesis). Supporting terms include enteric nervous system development and transepithelial chloride transport, which fit neural control of tissues. Nipple morphogenesis and operant conditioning are less central but can co-occur with developmental and behavioral neural pathways. Overall, this cluster centers on autonomic nervous system signaling and cardiovascular regulation.","confidence":"Medium","size":11,"edges":11,"triangles":1,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0060658","count":7},{"id":"GO:0035106","count":7},{"id":"GO:0035815","count":7},{"id":"GO:0001994","count":7}]},{"hash":"1381458067175306072","title":"Metal ion homeostasis and sulfation processes","description":"The top GO terms show a cluster around metal ion detoxification and intracellular homeostasis for zinc and cadmium, plus sulfation-related enzymatic modifications (peptidyl-tyrosine sulfation, sulfate assimilation). While some terms touch broader metabolic themes (catecholamine and estrogen metabolism, angiotensin regulation), the strongest thread is metal ion handling combined with sulfation/modification pathways. This suggests a function group centered on metal homeostasis and sulfation-related enzymatic modification.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":4},{"id":"GO:0030206","count":4},{"id":"GO:0010312","count":2},{"id":"GO:0006882","count":2},{"id":"GO:0070574","count":2}]},{"hash":"1581121809803273537","title":"Steroid and Retinoid Lipid Metabolism","description":"The GO terms cluster around lipid- and hormone-related metabolism, including testosterone/androgen, progesterone, prostaglandin, bile acid, and cholesterol pathways, along with retinol/retinal metabolism, indicating a cohesive theme of steroid/prostaglandin/lipid hormone and vitamin A metabolism.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":4},{"id":"GO:0008209","count":4},{"id":"GO:0001516","count":4},{"id":"GO:0006699","count":3},{"id":"GO:0006707","count":3}]},{"hash":"1995346251549456446","title":"Hematovascular development and stress response","description":"The cluster includes erythrocyte differentiation/maturation terms (enucleate erythrocyte differentiation, erythrocyte maturation), heart development, and blood vessel maintenance, along with responses to hypoxia, oxidative (hydrogen peroxide) and nitrosative stress, and toxic substances. This pattern points to a shared theme of hematovascular development coupled with cellular stress responses.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042542","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0043353","count":2},{"id":"GO:0043249","count":2}]},{"hash":"1401262782472682787","title":"P-body RNA processing and miRNA regulation","description":"This cluster is characterized by GO terms pointing to post-transcriptional control, especially P-body assembly and regulation of miRNA-mediated gene silencing, plus cytoplasmic mRNA processing body dynamics. While some terms relate to development in sensory organs, the strongest signal is RNA granule\u2013mediated regulation of mRNA, justifying a label centered on P-bodies and miRNA pathways.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060965","count":2},{"id":"GO:0033962","count":2},{"id":"GO:0042051","count":2},{"id":"GO:0002091","count":2},{"id":"GO:0009994","count":2}]},{"hash":"1813452296809725363","title":"Neural signaling and sensory processing","description":"The terms cluster around nervous system signaling and sensory pathways: nerve impulse transmission, sound perception, optic nerve morphogenesis, GABA receptor clustering, acetylcholine receptor signaling, dopamine secretion, and innervation, including autonomic regulation of heart rate. Together they point to proteins involved in neuronal communication and sensory system development.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051971","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0021771","count":3},{"id":"GO:0097112","count":3},{"id":"GO:0001988","count":3}]},{"hash":"577024469990365030","title":"Integrin signaling and cytoskeleton regulation in bone formation","description":"The cluster shows strong enrichment for integrin-mediated signaling, regulation of stress fiber assembly and actin cytoskeleton organization, and cell adhesion, plus bone-related processes such as bone mineralization and growth hormone receptor signaling. Taken together, these terms point to a module coordinating cytoskeletal dynamics and adhesion with osteogenic signaling and bone formation. Some terms about proliferation and polarity are ancillary but do not override the central integrin-cytoskeleton-bone theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0051492","count":5},{"id":"GO:0008285","count":5},{"id":"GO:2000114","count":5},{"id":"GO:0033628","count":5},{"id":"GO:0007229","count":5}]},{"hash":"1596986865600304988","title":"Spliceosome and RNA Processing","description":"This cluster is dominated by GO terms for mRNA splicing via spliceosome, spliceosomal snRNP and complex assembly, as well as tRNA processing and maturation of SSU-rRNA, pointing to core RNA processing and spliceosome machinery. The presence of P-body assembly supports RNA regulation at post-transcriptional levels. A few terms (e.g., hair cycle, water deprivation) are broader physiological processes and less central, but the overall theme centers on RNA splicing and ribonucleoprotein assembly, making this label appropriate.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":8},{"id":"GO:0008033","count":6},{"id":"GO:0030490","count":5},{"id":"GO:0070317","count":5},{"id":"GO:0033962","count":5}]},{"hash":"2016424740537186152","title":"RNA processing and stress-related translation control","description":"Contains terms on mRNA splicing and export, stability in stress, translation initiation and reinitiation, mRNA modification, and stress granule localization, pointing to coordinated post-transcriptional regulation of RNA metabolism and translation during cellular stress.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0010610","count":4},{"id":"GO:1903608","count":3},{"id":"GO:0002188","count":3}]},{"hash":"975355700974348564","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0000028","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006085","count":1},{"id":"GO:0006099","count":1}]},{"hash":"1494285292852845667","title":"Mucosal innate immune response and lipid remodeling","description":"This cluster centers on defense and inflammatory signaling at mucosal surfaces, with terms for innate immune response, Gram-positive bacterial defense, and IL-1/IL-8 production, indicating mucosal inflammation. The inclusion of multiple phospholipid remodeling and biosynthesis processes suggests membrane lipid signaling linked to immune activation, supporting a theme of mucosal innate immunity coupled with lipid metabolism.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0036149","count":2},{"id":"GO:0050482","count":2},{"id":"GO:0036151","count":2},{"id":"GO:0032612","count":2}]},{"hash":"1117240830473680926","title":"Multi-tissue development","description":"The GO terms are distributed across eye/visual, neural, placental, liver, and dental development, indicating a broad developmental role rather than a single pathway. This cluster seems to reflect general organogenesis processes rather than a specific function, hence a broad label with Moderate confidence.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042682","count":1},{"id":"GO:0072095","count":1},{"id":"GO:1900215","count":1},{"id":"GO:0042481","count":1},{"id":"GO:0021978","count":1}]},{"hash":"567656014646152142","title":"Mitochondrial apoptosis regulation","description":"The top GO terms cluster around mitochondrial processes and apoptotic regulation, including negative regulation of mitochondrial depolarization, anti-apoptotic signaling, and release of cytochrome c, indicating a cohesive theme of controlling mitochondrial-mediated apoptosis. While there are a few terms related to brain development and lipid metabolism, these appear secondary to the core apoptotic/mitochondrial theme. ","confidence":"Medium","size":10,"edges":11,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043154","count":1},{"id":"GO:0051902","count":1},{"id":"GO:2001240","count":1},{"id":"GO:0001836","count":1},{"id":"GO:0007420","count":1}]},{"hash":"443651770416818677","title":"Mitotic spindle assembly and cytokinesis","description":"This cluster is dominated by GO terms related to cytoplasmic microtubule organization, spindle pole body duplication, spindle midzone assembly, microtubule nucleation, and various aspects of cell division and cytokinesis, pointing to a cohesive role in mitotic spindle dynamics and completion of cell division. The interleukin-4 response term appears peripheral to the main theme. High","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0031122","count":10},{"id":"GO:1903087","count":10},{"id":"GO:0051256","count":10},{"id":"GO:0071353","count":10},{"id":"GO:0007020","count":10}]},{"hash":"555616069695505454","title":"Neural development and angiogenesis signaling","description":"This cluster is dominated by neural development terms (cerebral cortex layer formation and axonogenesis) and angiogenesis, suggesting coordinated neural and vascular development. Supporting signals (angiotensin-activated pathways, PKC, STAT phosphorylation, phosphatidylinositol signaling) indicate broader developmental signaling networks. While energy metabolism and UPR-related terms appear, they are less defining for the cluster\u2019s main theme. ","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0021819","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0086098","count":1},{"id":"GO:0032784","count":1}]},{"hash":"393451304787262131","title":"Hormone-Responsive Metabolic Pathways","description":"The GO terms point to retinol/retinal and carbohydrate metabolism (retinol/retinal metabolic processes, fructose biosynthesis, D-xylose catabolic process) together with multiple hormone-related responses (response to thyroid hormone, cellular response to prostaglandin D, testosterone biosynthetic process) and stress signaling (stress-activated protein kinase cascade, cellular response to hydrogen peroxide). This combination suggests a cluster where metabolic activities are modulated by endocrine signals and stress responses, rather than a single isolated pathway.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":9},{"id":"GO:0042574","count":8},{"id":"GO:0046370","count":7},{"id":"GO:0042843","count":6},{"id":"GO:0097066","count":6}]},{"hash":"1041076105749779905","title":"Hormone and Xenobiotic Metabolism","description":"The top GO terms point to processing and breakdown of hormones (estrogen catabolic process; regulation of angiotensin levels; catecholamine metabolism) along with detoxification pathways (xenobiotic metabolism; bile acid catabolic process; sulfate assimilation). Although a few terms are outdated or development-related, the dominant signal is enzymes involved in metabolizing endogenous hormones and xenobiotics, suggesting a coherent theme of hormone and small-molecule detoxification/metabolism.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":7},{"id":"GO:0030206","count":7},{"id":"GO:0006711","count":6},{"id":"GO:0002002","count":6},{"id":"GO:0006584","count":6}]},{"hash":"772895636009961801","title":"Steroid, retinoid, and pigment biosynthesis","description":"The top GO terms are dominated by biosynthetic and metabolic processes, notably testosterone/androgen biosynthesis and metabolism, retinal and retinol metabolism, and melanin biosynthesis. While terms like sporulation and lung development are less directly related, the overall signal points to coordinated biosynthetic/metabolic activities across steroids, retinoids, and pigments. Confidence: Medium","confidence":"","size":10,"edges":5,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0061370","count":4},{"id":"GO:0008209","count":4},{"id":"GO:0042574","count":3},{"id":"GO:0030435","count":3},{"id":"GO:0055114","count":3}]},{"hash":"214765967475647348","title":"Embryonic neural and eye development","description":"The TOP terms indicate early embryo development of the nervous system and visual structures, including forebrain development, retinal/nerve ganglion formation and axon guidance, embryonic eye morphogenesis, glial differentiation, organ induction, and somitogenesis regulation, collectively pointing to neural and ocular organogenesis in the embryo.","confidence":"High","size":10,"edges":8,"triangles":0,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007338","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0061551","count":5},{"id":"GO:0031290","count":5},{"id":"GO:0001759","count":5}]},{"hash":"878932473762928005","title":"Sterol biosynthesis and xenobiotic response","description":"Most prominently, the cluster is enriched for sterol biosynthesis terms (ergosterol biosynthetic process and cholesterol biosynthetic process), suggesting involvement in membrane lipid metabolism. The presence of response to xenobiotic stimulus supports a broader detox or stress-response role. A couple of terms (mitochondrion inheritance, apoptotic process) are less directly tied but may reflect general cellular maintenance in the same proteome set. Overall, the strongest shared theme is synthesis of sterols and related lipid metabolism with xenobiotic response.","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0006696","count":2},{"id":"GO:0006695","count":2}]},{"hash":"945282962139039968","title":"mRNA processing and translation regulation","description":"The proteins in this cluster are enriched for post-transcriptional RNA processes: splicing regulation, mRNA export, modification, stability under stress, splice-site recognition, and multiple steps in initiating or reinitiating translation. This points to a cohesive role in RNA maturation and control of protein synthesis.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0002188","count":6},{"id":"GO:0016556","count":6},{"id":"GO:1901407","count":6}]},{"hash":"2132259520781873041","title":"Organelle Protein Import and Localization","description":"The top GO terms cluster around import and insertion of proteins into organelles (mitochondria and chloroplasts) and related localization processes, with supporting signals for ER localization and organelle transport. Despite a few noisy or obsolete terms, the dominant theme is proteins involved in targeting/import into organelles.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":2},{"id":"GO:0030150","count":1},{"id":"GO:0000002","count":1},{"id":"GO:0045037","count":1},{"id":"GO:0032094","count":1}]},{"hash":"1442850337364394324","title":"Redox-Linked tRNA Modification and Cofactor Biosynthesis","description":"The cluster\u2019s top GO terms are dominated by redox-related processes (cell redox homeostasis and Mo-molybdopterin cofactor biosynthesis) and RNA modification (tRNA seleno-modification and wobble uridine thiolation). Developmental terms are present but peripheral, suggesting the core theme centers on redox metabolism intertwined with RNA modification and cofactor biosynthesis rather than a specific tissue or signaling pathway.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":7},{"id":"GO:0021510","count":4},{"id":"GO:0035335","count":4},{"id":"GO:0070329","count":3},{"id":"GO:0018192","count":3}]},{"hash":"296944109307752925","title":"Growth and morphogenesis signaling regulators","description":"This cluster is enriched for regulation of signaling activities (GTPase, kinase, phosphorylation) and developmental processes, including face morphogenesis, osteoblast proliferation, and mammary gland/bone marrow development, suggesting proteins that modulate signaling to drive growth and tissue morphogenesis.","confidence":"Medium","size":10,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0010800","count":2},{"id":"GO:0030307","count":2},{"id":"GO:0007275","count":2}]},{"hash":"308519914011410722","title":"RNA Processing and Protein Degradation","description":"The cluster\u2019s GO terms cover RNA processing activities (mRNA splicing via spliceosome, polyadenylation) alongside translation initiation and reinitiation, plus multiple ubiquitin-dependent proteolysis pathways (protein ubiquitination, SCF-proteasome degradation, ERAD). This combination points to a set of proteins involved in regulating gene expression at both RNA processing and protein turnover levels, rather than a single, cohesive pathway. Some terms are obsolete or development-focused, but the overarching theme appears to be coordination of RNA processing with protein quality control. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0045292","count":3}]},{"hash":"901843379425879439","title":"ER-Golgi Trafficking and Secretion","description":"This cluster centers on COPI-coated vesicles, ER-to-Golgi transport, COPI budding, Golgi ribbon formation, and protein retention or exit from the ER lumen, indicating a coherent secretory pathway/ER\u2013Golgi trafficking theme. While a few terms touch on development or disease (maternal axis specification, aggression, amyloid-beta regulation), the dominant signals are components and regulation of secretion through the ER-Golgi system.","confidence":"High","size":10,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007311","count":3},{"id":"GO:0048205","count":3},{"id":"GO:0035964","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0090161","count":3}]},{"hash":"1161373376252120561","title":"Unknown","description":"The top GO terms span DNA replication, cell-cycle regulation, immune signaling (cytokine production and T cell proliferation), stress and environmental responses (LPS, pollen, cocaine), and anoikis regulation, with no clear shared function. The absence of edges suggests little functional coherence, so a single specific label cannot be assigned with confidence.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":10},{"id":"GO:1901925","count":9},{"id":"GO:0045401","count":9},{"id":"GO:0045425","count":9},{"id":"GO:0071222","count":9}]},{"hash":"1683487988006509608","title":"Spliceosome and mRNA Processing","description":"This cluster is dominated by GO terms for mRNA splicing and processing (spliceosome, splice site recognition, preinitiation translation steps, mRNA export, and mRNA modification), with signals of regulation and stress-responsive mRNA stability. These proteins likely function together in RNA maturation and export rather than other cellular processes, justifying a cohesive label around spliceosome-mediated mRNA processing.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":5}]},{"hash":"804924022049504974","title":"Cardiac electromechanical signaling","description":"This cluster centers on cardiac electrical activity and mechanical sensing, with GO terms for atrial action potential, SA node regulation, and cellular responses to mechanical stimulus and muscle stretch, suggesting a shared role in heart electromechanical signaling. Some immune-related terms and apoptosis-related terms appear as outliers, but the core pattern points to heart cell signaling and mechanotransduction.","confidence":"Medium","size":10,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002377","count":3},{"id":"GO:0086014","count":3},{"id":"GO:0072660","count":3},{"id":"GO:0035994","count":3},{"id":"GO:2000002","count":3}]},{"hash":"1799804492578609726","title":"Organ Development and Epigenetic Regulation","description":"Represents a theme of organ development paired with epigenetic regulation (nucleosome assembly, histone methylation, and DNA demethylation). The included terms point to morphogenesis of organs (thymus, placenta, general animal organ development) alongside chromatin-related processes, though the lack of edges and obsolete terms indicate a loose, dispersed association rather than a tightly connected module.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901536","count":1},{"id":"GO:0080182","count":1},{"id":"GO:0060669","count":1},{"id":"GO:2000584","count":1},{"id":"GO:0070562","count":1}]},{"hash":"229449616307454368","title":"Rho/Rac GTPase signaling and cell migration","description":"The top GO terms center on regulation and signaling of Rho family GTPases (Rho and Rac), including small GTPase-mediated signal transduction, lamellipodium assembly, and cell migration. These collectively point to actin cytoskeleton remodeling and directed cell movement, which is the core theme linking the majority of terms. While a few entries touch on development or immune-related processes, the dominant signal is cytoskeletal dynamics driven by Rho/Rac pathways.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0098761","count":5},{"id":"GO:0060065","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0001865","count":5}]},{"hash":"1727628343282260210","title":"Chromatin organization and nucleosome assembly","description":"The top GO terms center on chromatin and nucleosome biology\u2014heterochromatin organization, nucleosome assembly, localization to chromatin, and histone modification marks (even if some terms are deprecated). These collectively suggest a cluster of proteins involved in chromatin structure and its regulation, with a few ancillary terms (protein degradation and signaling) likely reflecting broader regulatory connections. ","confidence":"High","size":10,"edges":15,"triangles":6,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":2},{"id":"GO:0070828","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0097298","count":2},{"id":"GO:0016584","count":2}]},{"hash":"2011112833871038287","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":1},{"id":"GO:0010526","count":1},{"id":"GO:0000395","count":1},{"id":"GO:0048026","count":1},{"id":"GO:0010087","count":1}]},{"hash":"227965876201591169","title":"Unknown","description":"The GO terms present cover a wide and disparate range of biology (metabolic response to insulin, interferon immune responses, neuromuscular/posture control, synaptic vesicle clustering, endosomal transport, host-symbiont interactions, biotic response, and bone development), with no dominant shared function or pathway. The lack of network connectivity (Edges: 0) and no clear theme across terms support labeling this cluster as Unknown rather than a specific biological process. ","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":1},{"id":"GO:0035455","count":1},{"id":"GO:0050884","count":1},{"id":"GO:0097091","count":1},{"id":"GO:0046597","count":1}]},{"hash":"2230235684208981211","title":"Zinc Ion Transport and Detoxification","description":"The cluster prominently includes GO terms tied to zinc metabolism: zinc ion import across the plasma membrane and detoxification of zinc ion, suggesting a core theme of zinc homeostasis. Other terms are heterogeneous (thyroid hormone metabolism, visual perception, heart development) and some are obsolete, indicating annotation noise; however, the zinc-related annotations provide the strongest unifying signal for the cluster.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0007507","count":2}]},{"hash":"44646851085889117","title":"Immune signaling and cytokine production","description":"The most represented GO terms are immune-related: negative regulation of macrophage activation; dendritic cell cytokine production; mast cell cytokine production; Fc receptor signaling; and STAT phosphorylation. These indicate a cluster enriched for immune receptor signaling and cytokine regulation. A couple of terms like angiogenesis and skeletal development appear but are not the dominant theme; the core is immune modulation.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0043031","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0002371","count":5}]},{"hash":"225172376478198694","title":"Plant cell wall biosynthesis and pollen exine formation","description":"Based on the GO terms, most entries are involved in cell wall organization and biosynthesis in plants (secondary cell wall biogenesis, glucuronoxylan biosynthesis, pollen exine formation). Some proteoglycan biosynthetic terms appear but align with wall matrix components; a couple of stress/response terms are less representative.","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":1},{"id":"GO:0050651","count":1},{"id":"GO:0010584","count":1},{"id":"GO:0030204","count":1},{"id":"GO:0050650","count":1}]},{"hash":"904278247894691439","title":"Sulfation-linked steroid and xenobiotic metabolism","description":"The top GO terms cluster around peptidyl-tyrosine sulfation and metabolic pathways for steroids (estrogen catabolic process), catecholamines, bile acids, and xenobiotics, suggesting a general role in sulfation-related modification and detoxification of diverse compounds. While diverse, the shared theme is metabolism and processing of sulfur-containing or modified molecules.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006478","count":4},{"id":"GO:0006711","count":3},{"id":"GO:0002002","count":3},{"id":"GO:0006584","count":3},{"id":"GO:0000103","count":3}]},{"hash":"367469646501055495","title":"Cell Wall Biosynthesis and Morphogenesis","description":"Top GO terms indicate cell wall organization and multiple carbohydrate biosynthetic processes (lipid A, starch, glycogen, peptidoglycan, dTDP-rhamnose). Coupled with terms for regulation of cell shape and cell morphogenesis, the cluster likely groups proteins involved in cell wall biogenesis and the shaping of cells.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0009245","count":2},{"id":"GO:0019252","count":2},{"id":"GO:0005978","count":2},{"id":"GO:0080147","count":2}]},{"hash":"489776818611740093","title":"Inflammation and Stress Response","description":"The top GO terms cluster around immune/inflammatory processes (inflammatory response, defense against bacterium, xenobiotic stimulus) and general stress signaling (temperature stimulus, pain). ERK1/ERK2 cascade regulation and coagulation fit into inflammatory signaling and tissue responses. A few terms like phototransduction and diet-induced thermogenesis may reflect broader metabolic/sensory roles, but the dominant theme is cellular response to external stimuli, especially inflammation and immune defense.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0045986","count":3},{"id":"GO:0006954","count":3}]},{"hash":"463936698308816090","title":"Mitotic Chromosome Segregation Machinery","description":"The strongest signal in this cluster is mitosis-related: mitotic cell cycle, mitotic sister chromatid segregation, and general cell division, along with CENP-A chromatin assembly. While there are also terms tied to RNA export, ER-Golgi transport, translation reinitiation, and microtubule remodeling, the dominant theme is proteins involved in chromosome segregation and cell cycle progression. ","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0051013","count":2}]},{"hash":"2279936409802834787","title":"Membrane transporters (diverse substrates)","description":"The top GO terms are dominated by transmembrane transport activities (bicarbonate, sulfate, oxalate, and L-aspartate transport) and processes related to membrane potential and intracellular pH, suggesting these proteins function primarily as membrane transporters handling diverse substrates. A few outliers (spliceosomal assembly, sporulation, transcription regulation) may reflect annotation noise or multifunctionality, but the shared theme is transport across membranes.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":2},{"id":"GO:0042391","count":1},{"id":"GO:0001696","count":1},{"id":"GO:0019532","count":1},{"id":"GO:0051454","count":1}]},{"hash":"721114278949155935","title":"Bacterial energy metabolism and motility","description":"This cluster centers on energy production and carbon metabolism, with GO terms for NADH-to-ubiquinone electron transport, the TCA cycle, and various catabolic pathways (oxalate, carnitine, formate) as well as carbon fixation. The inclusion of photosynthetic electron transport in photosystem I and bacterial-type flagellum assembly suggests a photosynthetic, motile bacterium with diverse metabolic capabilities. Translation appears as a general background process, not defining the cluster. Medium","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0043427","count":1},{"id":"GO:0033611","count":1}]},{"hash":"1008629672926919998","title":"Unknown","description":"The GO terms span development, epigenetic regulation, ubiquitination, immune and stress responses, metal ion response, morphine signaling, and mitosis, with no clear shared function tying all nine proteins. With no edges and a heterogeneous set of functions, there isn\u2019t a coherent, single theme to label confidently.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0061087","count":2},{"id":"GO:0070979","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0051607","count":2}]},{"hash":"1345710126178721973","title":"Calcium-Dependent Neural Signaling in Schwann Cells","description":"The terms emphasize calcium-dependent signaling (calcium detection, calcineurin-NFAT cascade) and neural/schwann cell biology (Schwann cell development, cocaine response), suggesting proteins function in calcium-mediated neural signaling and Schwann cell development, with some metabolic biosynthesis terms likely annotation noise.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009245","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0019252","count":2},{"id":"GO:0005978","count":2},{"id":"GO:0005989","count":2}]},{"hash":"458273841749203974","title":"Neural development and axon guidance signaling","description":"These terms cluster around nervous system development and axon guidance (nervous system development, axon guidance, Roundabout/Robo signaling, smoothened/SHH signaling), suggesting a cohesive neural development signaling module, with some related morphogenesis terms as secondary signals.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060445","count":4},{"id":"GO:0021682","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0007399","count":4}]},{"hash":"1737126969438424337","title":"Translation and Translational Stress Response","description":"This cluster is dominated by translation-related terms (GO:0006412 and GO:0006413) and stress-related responses to amino acid starvation and inhibitors like cycloheximide or antibiotics, suggesting a group of proteins tied to protein synthesis and its stress signaling. Some peripheral terms (cell cycle, transcription) may reflect broader cellular roles but do not define the core theme. Overall, the proteins seem connected to translation machinery and its stress responses rather than a single cohesive pathway, hence the name.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0006413","count":3},{"id":"GO:0034198","count":3},{"id":"GO:0000082","count":2},{"id":"GO:0046898","count":2}]},{"hash":"405504241294459526","title":"Ubiquitin-Dependent Protein Turnover and NF-\u03baB Signaling","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent proteolysis, ERAD, K63-linked ubiquitination) and immune signaling components (TNF signaling, NF-\u03baB activation), with links to chromatin-related events (V(D)J recombination, histone ubiquitination). This points to a cohesive theme of ubiquitin-mediated regulation of protein turnover and immune signaling pathways.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0009048","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0033151","count":3}]},{"hash":"260261282167194771","title":"Diverse tissue development","description":"Diverse tissue development is suggested by GO terms spanning kidney development and filtration, smooth muscle and bone remodeling, cartilage (chondrocyte) development, CNS development and innervation, and GDNF receptor signaling. This pattern indicates a broad developmental role affecting multiple tissues rather than a single, cohesive molecular function, which is consistent with a heterogeneous cluster of proteins. The lone lipoteichoic acid term may be an annotation artifact, and there are no interactions within the cluster, reinforcing a non-specific developmental theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032836","count":3},{"id":"GO:0048745","count":2},{"id":"GO:0046849","count":2},{"id":"GO:0035860","count":2},{"id":"GO:0060384","count":2}]},{"hash":"488096171484765559","title":"Peptide hormone processing and maturation","description":"This cluster is enriched for GO terms related to proteolytic processing of peptide hormones and neuropeptides, including dibasic protein processing, enkephalin processing, and insulin processing, as well as peptide pheromone maturation. While a few terms touch on unrelated developmental or receptor regulation processes, the strongest signal is peptide maturation and hormone activation.","confidence":"Medium","size":9,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1905601","count":4},{"id":"GO:0090472","count":4},{"id":"GO:0032902","count":4},{"id":"GO:1905598","count":4},{"id":"GO:0034230","count":4}]},{"hash":"429049916226459507","title":"Muscle and neuronal membrane excitability","description":"This cluster centers on genes associated with regulation of membrane potential, cardiac and skeletal muscle action potentials, and potassium transport, indicating a common theme of membrane excitability and ion-based signaling in muscle and neural contexts. While there are additional terms related to hormone response and immune signaling, the strongest overlap is in ion homeostasis and excitability that underpin muscle contraction and neuronal activity.","confidence":"Medium","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":"nervous system process","top_go_terms":[{"id":"GO:0071333","count":4},{"id":"GO:0043330","count":4},{"id":"GO:0014861","count":3},{"id":"GO:0032355","count":3},{"id":"GO:1905965","count":3}]},{"hash":"1554677581686457566","title":"Developmental Growth Regulation","description":"The cluster\u2019s frequent GO terms center on regulating growth and development across multiple tissues (kidney, adrenal gland, limb, trophoblast), with several items tied to inhibiting signaling pathways (BMP and nitric oxide) and apoptosis. Though a few terms appear unrelated or odd (e.g., microcystin transport, an obsolete term), the dominant theme is development and growth control, suggesting these proteins collectively participate in developmental growth regulation.","confidence":"High","size":9,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":3},{"id":"GO:0043066","count":2},{"id":"GO:1905431","count":2},{"id":"GO:0019800","count":2},{"id":"GO:0001822","count":2}]},{"hash":"380200522786609355","title":"Inhibitory synapse assembly and postsynaptic organization","description":"The top GO terms cluster around forming inhibitory synapses, assembling the postsynaptic membrane, and organizing the active zone cytoskeleton, plus regulation of synaptic vesicle clustering. The acetylcholine catabolic process in the synaptic cleft points to cholinergic neurotransmission, reinforcing a synapse-focused function. A few terms (DNA-templated transcription, neuroblast differentiation, cellulose catabolism) seem peripheral to synapse formation, possibly reflecting broader neuronal development signals or annotation noise, but the dominant theme is synaptic assembly and neurotransmission.","confidence":"Medium","size":9,"edges":28,"triangles":42,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1904862","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0097104","count":3},{"id":"GO:0048789","count":3},{"id":"GO:0001507","count":3}]},{"hash":"1744038380777551549","title":"Membrane adhesion and surface organization in development","description":"This cluster centers on membrane- and surface-associated processes: cell-matrix adhesion, localization to the cell surface, and membrane assembly (postsynaptic/presynaptic). The developmental terms (coronary vasculature development, eye morphogenesis) further support a theme of membrane- and adhesion-mediated developmental regulation. Some terms are obsolete or broad, but the membrane/surface theme is the strongest signal across the set. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0044332","count":4},{"id":"GO:0034394","count":4},{"id":"GO:0060976","count":3},{"id":"GO:0097104","count":3}]},{"hash":"351422848931529615","title":"Ribosome biogenesis and translation machinery","description":"The cluster is dominated by GO terms for translation and ribosome biogenesis (translation, preribosome large subunit assembly, tRNA wobble modification), indicating proteins involved in ribosome assembly and protein synthesis. Additional terms point to translation regulation and related cellular processes, with a few outliers (response to antibiotic, cobalamin biosynthesis, cell cycle) that may reflect broader context but do not override the central ribosome/translation theme.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0046677","count":2},{"id":"GO:0090070","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0009236","count":1}]},{"hash":"763172264185971087","title":"Cell Polarity and Cytoskeleton Organization","description":"The dominant GO terms cluster around establishing cell polarity and organizing the actin cytoskeleton (cell shape regulation, mesenchyme migration, actin localization), signaling a shared role in cytoskeletal remodeling and cell movement. Related terms about mitochondrion localization and skeletal muscle thin filament assembly further support a unifying theme of cytoskeleton-driven organization across contexts.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071963","count":7},{"id":"GO:0090131","count":7},{"id":"GO:0043983","count":7},{"id":"GO:0051666","count":7},{"id":"GO:1904623","count":7}]},{"hash":"1056607229697403393","title":"Vertebrate organogenesis and neural development","description":"The top GO terms point to broad embryonic development across multiple tissues (kidney ureteric bud, placenta, liver) and to neural patterning and brain development (telencephalon regionalization, cerebral cortex interneuron differentiation, midbrain-hindbrain boundary), with supporting terms like visual perception and neuromuscular processes. This suggests a common theme of vertebrate organogenesis with substantial emphasis on neural development, rather than a single tightly defined function.","confidence":"Medium","size":9,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0072095","count":3},{"id":"GO:0021978","count":3},{"id":"GO:0021854","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0001889","count":3}]},{"hash":"449826026127367254","title":"Inflammation, complement activation, and coagulation","description":"These terms cluster around innate immune signaling (IL-1 response), complement activation (lectin pathway), coagulation and platelet function, and recognition of apoptotic cells, suggesting a cohesive inflammation-hemostasis theme; incidental terms like UV-B response and axon regeneration likely reflect injury-associated stress responses that occur alongside such processes.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":6},{"id":"GO:2000352","count":6},{"id":"GO:0001867","count":5},{"id":"GO:0071347","count":5},{"id":"GO:0072378","count":5}]},{"hash":"1598661561044153608","title":"Platelet activation and innate immune signaling","description":"The top terms cluster around platelet aggregation, coagulation, and complement activation, with inflammatory signaling (interleukin-1) and immune-related processes like apoptotic cell recognition. Although a couple terms (UV-B response, NMJ axon regeneration) are less directly connected, the dominant theme is hemostasis together with innate immune activation, suggesting this cluster reflects inflammatory-coagulation interplay.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0071347","count":5},{"id":"GO:0072378","count":5},{"id":"GO:0071493","count":5},{"id":"GO:0014814","count":5}]},{"hash":"1392435875436476565","title":"Unknown","description":"The terms span cold and starvation responses, leucine catabolism, various developmental processes (heart, cerebral cortex, labyrinthine vessel), apoptosis regulation, granulocyte differentiation, and sperm capacitation. There is no single unifying function linking all proteins in this cluster, making a specific label inappropriate.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0042594","count":3},{"id":"GO:0006552","count":3},{"id":"GO:0007507","count":3}]},{"hash":"21517525867912127","title":"Mitochondrial Electron Transport & Complex Assembly","description":"The cluster is dominated by GO terms relating to mitochondrial energy metabolism, including electron transport (succinate to ubiquinone), and assembly of respiratory chain complexes II and IV, plus protein import into the mitochondrial matrix and protein flavinylation/FAD linkage. A translation/transcription terms appear less prominently, but the mitochondrial processes are the clear signal.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006351","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0030150","count":1}]},{"hash":"2271385166806612959","title":"Mitochondrial tRNA Aminoacylation and Translation","description":"The dominant GO terms point to mitochondrial tRNA charging (aspartyl, lysyl, asparaginyl) and translation, indicating the cluster centers on mitochondrial protein synthesis; non-dominant terms like DNA repair or telomere localization appear incidental rather than defining the group.","confidence":"High","size":9,"edges":11,"triangles":3,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0070146","count":5},{"id":"GO:0006412","count":5},{"id":"GO:0070154","count":5},{"id":"GO:0070145","count":5},{"id":"GO:0071915","count":5}]},{"hash":"13784512083717995","title":"DNA replication and repair with proviral integration","description":"This cluster centers on core DNA metabolic processes (replication, recombination, repair, transcription) and includes terms related to DNA integration and establishment of proviral latency, suggesting involvement in DNA maintenance coupled with viral genome integration and latency. The combination of these DNA-centric functions with proviral latency terms indicates a cohesive theme around host DNA processing and retroviral genome integration.","confidence":"High","size":9,"edges":31,"triangles":55,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006310","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0006281","count":4},{"id":"GO:0006351","count":3}]},{"hash":"919666560724718962","title":"DNA replication and cell cycle machinery","description":"The cluster is dominated by nuclear processes (DNA replication, DNA-templated transcription, DNA repair, and mitotic cell cycle), suggesting proteins involved in genome maintenance and cell division. A subset of terms also points to immune signaling, possibly reflecting regulatory cross-talk or pleiotropy, but the core theme remains nuclear function.","confidence":"High","size":9,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0006351","count":8},{"id":"GO:0006281","count":7},{"id":"GO:0000278","count":7},{"id":"GO:1901925","count":6}]},{"hash":"2259011372703501592","title":"Cell cycle and DNA replication","description":"Top GO terms center on DNA replication, G1/S transition, meiotic and mitotic cell cycles, and kinetochore localization, suggesting proteins involved in cell division and chromosome maintenance. A few terms (mitochondrial DNA repair, neural development, and signaling) may reflect multifunctional roles or tissue-specific contexts, but the dominant signal is cell-cycle\u2013related.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0097552","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0034501","count":4}]},{"hash":"1540761636840295380","title":"Retroviral life cycle and proviral latency","description":"The proteins cluster around key retroviral life cycle processes: DNA integration, proviral latency, reverse transcription (RNA-templated DNA synthesis), entry into host cells, and DNA recombination/replication. There are also host response and evasion signals (negative regulation of siRNA processing and TNF production modulation) that align with viral manipulation of host defenses. This combination strongly supports a retroviral life cycle theme.","confidence":"High","size":9,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0006260","count":2},{"id":"GO:1903704","count":2}]},{"hash":"1381028818105492405","title":"Translation Initiation and Fidelity Regulation","description":"Most GO terms point to translation initiation and control: translation reinitiation, formation of the translation preinitiation complex, and regulation of translation with maintenance of translational fidelity. A few terms suggest stress or immune-related processes and ubiquitination, but they are less represented and do not define the cluster's main function.","confidence":"High","size":9,"edges":9,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006915","count":1},{"id":"GO:0070269","count":1},{"id":"GO:0016567","count":1}]},{"hash":"1765745195664158225","title":"Innate and adaptive immune signaling cluster","description":"The top GO terms are dominated by innate immune response and B cell receptor signaling, with apoptotic process and regulation of T cell activity also prominent, pointing to a core theme of immune signaling and cell fate decisions; additional terms appear more general (transcription, development) and may reflect multifunctional proteins, but the immune pattern is strongest.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0006915","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0010765","count":4},{"id":"GO:0046007","count":4}]},{"hash":"1190290075149154364","title":"Mitotic division and growth signaling","description":"The top GO terms are dominated by cell-division and mitotic processes (mitotic sister chromatid segregation; Okazaki fragment processing in mitotic DNA replication; cell division; regulation of meiotic nuclear division), with a supporting signal from TORC1-related growth regulation. Additional terms point to cytoskeletal dynamics (actin filament depolymerization) and vesicle trafficking (COPII-coated vesicle budding), suggesting a cluster centered on division-linked growth and cellular organization. Eye development terms appear as peripheral annotations rather than defining the core function, so they don\u2019t override the main theme. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000070","count":5},{"id":"GO:1903461","count":5},{"id":"GO:1904263","count":5},{"id":"GO:0090114","count":5},{"id":"GO:0090344","count":5}]},{"hash":"1682681058411788165","title":"Cerebellar development and Bergmann glia differentiation","description":"The dominant terms point to cerebellar development, cerebellar cortex formation, Bergmann glial cell differentiation, and neuron development, suggesting a neural development/Cerebellum-focused cluster. Additional terms such as insulin signaling and T cell receptor signaling appear, likely as peripheral noise or dual-function proteins, but do not define the core theme.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0032435","count":7},{"id":"GO:0048666","count":7},{"id":"GO:0048679","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0021697","count":5}]},{"hash":"1205524956092663967","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":12,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":3},{"id":"GO:0045039","count":3},{"id":"GO:0072321","count":3},{"id":"GO:0006810","count":2},{"id":"GO:0050826","count":2}]},{"hash":"762151668420203247","title":"Neuroendocrine Feeding and Metabolism Signaling","description":"The terms include regulation of GABA, glutamate, and insulin secretion, along with hormone-mediated signaling and feeding/eating behavior, hinting at a cluster of proteins involved in neuroendocrine control of feeding and energy balance. GPI anchor biosynthesis is a general cellular process but may relate to membrane localization of secretion-related proteins, supporting a neuroendocrine signaling role.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":2},{"id":"GO:0014054","count":1},{"id":"GO:0014050","count":1},{"id":"GO:0032024","count":1},{"id":"GO:2000252","count":1}]},{"hash":"1966792547588284735","title":"Neuronal development and synapse assembly","description":"Top GO terms point to nervous system development (peripheral nervous system development), positive regulation of synapse assembly, and signaling events (ERK cascade, STAT phosphorylation, PI3K-related activity) coupled with cell\u2013cell adhesion, which together suggest neural development and synaptic formation as the cluster\u2019s core. While terms like heart development and symbiont entry into host cell appear, the dominant signal is neural development and synaptic organization. Therefore, the label Neuronal development and synapse assembly captures the main function.","confidence":"Medium","size":9,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0007422","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0042523","count":3}]},{"hash":"1092285061117183823","title":"Hormone and xenobiotic metabolism","description":"The cluster\u2019s top GO terms center on metabolism of hormones and exogenous compounds (estrogen catabolic, catecholamine, bile acid, xenobiotic metabolism, and angiotensin regulation), with a minor developmental term as an outlier. This suggests the proteins are linked by metabolic processing rather than structural or developmental roles.","confidence":"Medium","size":9,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":6},{"id":"GO:0030206","count":6},{"id":"GO:0006711","count":5},{"id":"GO:0002002","count":5},{"id":"GO:0006584","count":5}]},{"hash":"470614963841279346","title":"Plant root transporters and photomorphogenesis","description":"The top GO terms cluster around membrane transport of various solutes (myo-inositol, glucose, biotin, pantothenate, sodium ions) and related biosynthetic processes, suggesting a set of plasma membrane transporter proteins. In addition, terms about primary root development and photomorphogenesis regulation, plus blue light responses, point to a light-responsive growth theme in roots. Taken together, the cluster appears to represent nutrient/solute transporters tied to light-regulated root development.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015878","count":2},{"id":"GO:0015887","count":2}]},{"hash":"971055832224803282","title":"Photosynthesis and energy metabolism","description":"The top GO terms are dominated by photosynthesis, nonphotochemical quenching, and proton transmembrane transport, all pointing to energy capture/dissipation and membrane processes in photosynthetic contexts. While there are ancillary metabolic terms (e.g., xenobiotic degradation) and some unrelated functions, the core theme centers on photosynthetic energy metabolism, justifying this label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0061000","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0046381","count":2}]},{"hash":"1450106614818307220","title":"Neural development and dendrite morphogenesis","description":"The frequent GO terms center on nervous system development, hippocampus and cochlea morphogenesis, dendrite morphogenesis, and excitatory synaptic activity, indicating proteins involved in neural development and synapse formation. Additional terms point to regulatory signaling (JNK cascade, axonogenesis) that modulate these processes, reinforcing the CNS-focused theme.","confidence":"High","size":9,"edges":10,"triangles":2,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":4},{"id":"GO:0021766","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0048813","count":4}]},{"hash":"1038302989458224243","title":"Neuronal development and synaptic morphogenesis","description":"Based on the dominant GO terms, the proteins cluster around nervous system development, hippocampus development, axon and dendrite morphogenesis, and excitatory synaptic activity, indicating a cohesive role in neural development and synaptic shaping. Some terms like amino acid starvation and mast cell regulation appear as minor outliers, but the core signal is neural development and morphogenesis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":8},{"id":"GO:0021766","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0034198","count":8},{"id":"GO:0033138","count":8}]},{"hash":"2069373151351960240","title":"Drosophila developmental transcription and chromatin regulation","description":"The top GO terms point to regulation of transcription and histone acetylation, suggesting epigenetic control of gene expression. Developmental processes such as imaginal disc fusion and thorax closure, and sensory organ precursor fate determination, indicate involvement in Drosophila morphogenesis. While some ER-related terms are present, the overarching signal is transcriptional regulation and chromatin modification during development, grouping proteins likely coordinating gene expression during morphogenesis.","confidence":"Medium","size":9,"edges":11,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":1},{"id":"GO:0032469","count":1},{"id":"GO:0043966","count":1},{"id":"GO:0043983","count":1},{"id":"GO:0046529","count":1}]},{"hash":"84179875264821083","title":"Complement and coagulation immune response","description":"These proteins are enriched for complement activation (lectin pathway), plasminogen activation/fibrinolysis, and blood coagulation, forming a cohesive complement-coagulation/inflammatory module. The co-occurrence of adaptive immune response, IL-1 signaling, and cell-matrix adhesion suggests broader inflammatory and tissue-remodeling roles, consistent with an immune\u2013coagulation axis and associated angiogenesis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0031639","count":6},{"id":"GO:0045766","count":6},{"id":"GO:0002250","count":6},{"id":"GO:0007160","count":6}]},{"hash":"751135993339663440","title":"Neuronal vesicle trafficking and glutamate release","description":"This cluster centers on synaptic vesicle transport, clathrin-mediated endocytosis, and glutamate secretion, with supporting terms for Golgi localization and neural development (cerebellum structure, ventricle development). The combination suggests a shared role in neuronal vesicle cycling and glutamatergic signaling during neural formation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:2000370","count":2},{"id":"GO:0000187","count":2},{"id":"GO:0048491","count":2},{"id":"GO:0014047","count":2}]},{"hash":"51596816981431974","title":"Calcium-Dependent Developmental Signaling","description":"The top GO terms point to calcium signaling and development across multiple tissues: calcium ion detection, calcineurin-NFAT signaling, and protein dephosphorylation, plus domains involving Schwann cell development, skeletal muscle fiber development, vascular branching, and visual perception. This suggests a unifying theme of calcium-dependent signaling guiding development and differentiation in muscle, nerve, and vascular contexts.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":5},{"id":"GO:0007205","count":4},{"id":"GO:1905205","count":3},{"id":"GO:0033173","count":3},{"id":"GO:0032972","count":3}]},{"hash":"391810008045617647","title":"Immune activation and signaling","description":"Top terms cluster around both innate and adaptive immune processes: complement activation through the lectin pathway, phagolysosome assembly, and regulation of T cell activity (memory differentiation, homeostatic proliferation), as well as negative regulation of myeloid apoptosis and platelet activation. The heterophilic cell-cell adhesion term suggests leukocyte interactions, and while development-related terms appear, the dominant theme ties to immune system activation and regulation, including leukocyte-platelet crosstalk. Overall, the cluster seems representative of immune signaling and regulation.","confidence":"Medium","size":9,"edges":24,"triangles":26,"max_degree":7,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0051006","count":8},{"id":"GO:0001845","count":8},{"id":"GO:0007157","count":8},{"id":"GO:0010572","count":8}]},{"hash":"1106111419632863350","title":"Immune Activation and Cytokine Production","description":"The Top Terms cluster centers on immune signaling: terms for positive regulation of cytokine production (interleukin-3, granulocyte\u2013macrophage colony-stimulating factor), and cellular responses related to lipopolysaccharide, as well as T cell proliferation. Although a couple of terms are unrelated (pollen recognition, cocaine response), the dominant pattern is immune activation and cytokine-mediated communication, suggesting a cluster of proteins involved in immune signaling and inflammatory responses.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":9},{"id":"GO:0045401","count":9},{"id":"GO:0045425","count":9},{"id":"GO:0071222","count":9},{"id":"GO:2000811","count":9}]},{"hash":"30136253439234580","title":"Unknown","description":"The top GO terms span immune signaling (Fc-epsilon receptor signaling), apoptosis, vacuole fusion, astrocyte activation, connective tissue remodeling, calcium\u2013NFAT signaling, nuclear fusion, axonogenesis, muscle contraction regulation, and polysaccharide catabolism. This wide mix suggests no single cohesive function tying the proteins together, so a specific, representative label cannot be assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":3},{"id":"GO:0006919","count":3},{"id":"GO:0042144","count":3},{"id":"GO:0048143","count":2},{"id":"GO:1905205","count":2}]},{"hash":"356212480211923367","title":"MAPK signaling and cell cycle regulation","description":"Dominated by MAPK pathways (p38MAPK and ERK cascades) and PMA response, suggesting a MAPK signaling cluster. The presence of mitotic cell cycle and spindle checkpoint terms, plus nuclear transport and mRNA processing terms, implies links between signaling, cell-cycle control, and gene expression. Overall, these proteins likely function in MAPK-mediated signaling with connections to cell-cycle regulation.","confidence":"Medium","size":8,"edges":11,"triangles":6,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1904628","count":3},{"id":"GO:0038066","count":3},{"id":"GO:0032298","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0000278","count":3}]},{"hash":"281822728976992347","title":"ER-Golgi vesicle trafficking and SNARE dynamics","description":"The cluster\u2019s GO terms are dominated by vesicle transport within the early secretory pathway\u2014inter-Golgi cisterna vesicle-mediated transport, ER to Golgi vesicle transport, and SNARE complex disassembly\u2014together with ER polarization and protein processing. These strongly suggest a cohesive role in ER-Golgi trafficking and membrane fusion events, with other terms like ATP metabolism likely reflecting general cellular activity rather than defining the cluster\u2019s core function.","confidence":"High","size":8,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0048219","count":1},{"id":"GO:0061166","count":1},{"id":"GO:0016485","count":1},{"id":"GO:1903715","count":1}]},{"hash":"2012070878021827899","title":"Motor neuron axon guidance and migration","description":"The top terms cluster around motor neuron development and axon pathfinding (motor neuron axon guidance, peripheral nervous system neuron axonogenesis, lateral motor column neuron migration) and cell-matrix adhesion via integrin signaling, suggesting the proteins collaborate in axon guidance and neuronal migration through adhesion signals. Some outlier terms exist, but the main theme is coherent with neuronal guidance and adhesion.","confidence":"High","size":8,"edges":13,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0048936","count":5},{"id":"GO:0070527","count":5},{"id":"GO:0097477","count":5}]},{"hash":"1059830046492058139","title":"Rho-GTPase Signaling and Proliferation","description":"The cluster's top GO terms cluster around positive regulation of GTPase activity and Rho protein signaling, plus GPCR signaling and cell proliferation, suggesting a shared theme of signaling that governs cytoskeletal dynamics and growth. Some terms reference broader developmental processes (retina or nipple morphogenesis) and metabolism, but the core signal seems to be growth- and signaling-related via Rho/GTPase pathways.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0060041","count":7},{"id":"GO:0008283","count":7},{"id":"GO:0008284","count":7},{"id":"GO:0045777","count":7}]},{"hash":"514938225418846173","title":"mRNA processing and translation regulation","description":"Most terms cluster around post-transcriptional gene expression: splicing via the spliceosome, mRNA export, modification and stability in response to stress, and multiple steps of translation initiation (preinitiation complex formation, translation reinitiation, and regulation of translational initiation). This suggests a cohesive module focused on processing and regulating mRNA before and during translation, rather than transcription or degradation pathways.","confidence":"High","size":8,"edges":14,"triangles":10,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":4},{"id":"GO:0002188","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0016556","count":3},{"id":"GO:0010610","count":3}]},{"hash":"1091524611190045461","title":"DNA repair and chromatin remodeling","description":"The cluster is dominated by GO terms for transcription-coupled nucleotide-excision repair, double-strand break repair via synthesis-dependent strand annealing, chromatin remodeling, and regulation of transcription start site selection, all pointing to a DNA damage response intertwined with chromatin state control. Some items (ribosomal subunit biogenesis, RNA-protein cross-linking) may be ancillary or reflecting broader nuclear processes, while unrelated terms like responses to selenite and BDNF are less explanatory.","confidence":"High","size":8,"edges":6,"triangles":0,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006283","count":8},{"id":"GO:0045003","count":8},{"id":"GO:0042273","count":8},{"id":"GO:0043044","count":8},{"id":"GO:0009432","count":8}]},{"hash":"1209927119416054225","title":"Chromatin remodeling and transcriptional control","description":"These proteins tie together chromatin state regulation (heterochromatin formation, chromatin remodeling during transcription initiation, histone modification) with transcriptional repression, and include several development-related processes (osteoblast differentiation, oogenesis, midbrain morphogenesis). The dominant theme is chromatin-mediated control of transcription, with developmental signals providing broader context.","confidence":"High","size":8,"edges":10,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0007549","count":3},{"id":"GO:0001649","count":3}]},{"hash":"1145639101916849878","title":"Unknown","description":"The GO terms span neural signaling and ion transport, plus ribosome-related processes and immune responses, with no single cohesive function uniting all eight proteins. That mix suggests a heterogeneous set rather than a distinct biological module, so a specific, tight label is not reliable.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051971","count":2},{"id":"GO:0007628","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0006855","count":2}]},{"hash":"1134761155954621574","title":"Ammonium Transport and Nitrogen Utilization","description":"The cluster centers on ammonium transport (transmembrane and transepithelial) and regulation of nitrogen utilization, with supporting signals from methylammonium transport and nitrogen metabolism terms. Additional terms like carbon dioxide transport and iron/heme-related processes may reflect broader metabolic coordination, while growth-related terms under nutrient limitation hint at adaptive responses. Overall, the dominant theme is nitrogen uptake and utilization alongside related transport processes.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006784","count":2},{"id":"GO:0060586","count":1},{"id":"GO:0080181","count":1},{"id":"GO:0015670","count":1},{"id":"GO:0070634","count":1}]},{"hash":"709331038496836512","title":"Secretory Vesicle Trafficking and SNARE Assembly","description":"The cluster is dominated by GO terms for vesicle transport and secretion: ER-to-Golgi and Golgi-to-ER transport, Golgi vesicle fusion, vesicle targeting, and SNARE complex assembly, plus protein transport and exocytic activities like mucus secretion and neurotransmitter receptor insertion. While there are hints of related processes (lipid/triglyceride transport and dendrite morphogenesis regulation), the core theme centers on the secretory pathway and membrane trafficking.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":2},{"id":"GO:0034197","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0050775","count":2},{"id":"GO:0006903","count":2}]},{"hash":"1038896708772293778","title":"Proteostasis and Stress Response Regulators","description":"These eight proteins show enrichment across several stress-related processes, including DNA repair, deubiquitination and proteasome regulation, autophagy (aggrephagy), vesicle formation regulation, and responses to chemical/metal stress (cadmium, insecticide). The shared theme appears to be cellular stress responses and protein quality control rather than a single, narrow function, justifying a proteostasis-focused label with a moderate level of confidence.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070911","count":5},{"id":"GO:0016579","count":5},{"id":"GO:1905366","count":5},{"id":"GO:1901340","count":5},{"id":"GO:0017085","count":5}]},{"hash":"557560398781221604","title":"Amino Acid Biosynthesis and Central Metabolism","description":"Based on the GO terms, these proteins cluster around multiple biosynthetic pathways (lysine, serine, leucine, biotin) and central metabolism (acetyl-CoA and TCA cycle), suggesting a cohesive role in amino acid production and core metabolic processes. Confidence: High","confidence":"","size":8,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0006099","count":2},{"id":"GO:0009102","count":2}]},{"hash":"1963636694386802015","title":"K63-Linked Ubiquitination and Ubiquitin-Dependent Degradation","description":"The cluster is dominated by GO terms for ubiquitination (K63-linked ubiquitination, autoubiquitination) and ubiquitin-dependent protein catabolic processes, plus related mentions of ERAD and actin ubiquitination. Some immune-related terms (defense response to virus, T cell homeostasis, spleen development) point to broader regulatory roles; overall the shared theme is ubiquitin-mediated regulation of protein turnover and trafficking, justifying this label.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070534","count":7},{"id":"GO:0051865","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0035372","count":5},{"id":"GO:0042787","count":5}]},{"hash":"1294166688752380286","title":"Protein quality control and stress response","description":"The top GO terms cluster around protein ubiquitination and degradation (autoubiquitination, ERAD), unfolded protein response, and stress-related regulation (response to heat, hydrogen peroxide), along with post-translational targeting to membranes. This pattern points to a module focused on proteostasis and membrane-related processes under stress, rather than a single specific pathway, justifying a label centered on protein quality control and stress response.","confidence":"Medium","size":8,"edges":22,"triangles":29,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051865","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0090084","count":3},{"id":"GO:0000902","count":3},{"id":"GO:0000742","count":3}]},{"hash":"2152127964726071716","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071630","count":5},{"id":"GO:0034975","count":5},{"id":"GO:0006458","count":5},{"id":"GO:0035719","count":5},{"id":"GO:0051259","count":5}]},{"hash":"2300988660845026950","title":"Multitissue Development and Signaling","description":"These proteins are linked to developmental processes (axonogenesis, uterus development, development of secondary male sexual characteristics) and broad signaling pathways (PKC activation, angiotensin signaling), plus responses to mechanical and fungal stimuli and B cell proliferation. The set does not converge on a single pathway but points to general roles in tissue development and intercellular signaling across systems, hence a label capturing multitissue development and signaling.","confidence":"Medium","size":8,"edges":9,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007409","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0045779","count":6},{"id":"GO:0071226","count":6},{"id":"GO:0046544","count":6}]},{"hash":"967903439625555406","title":"Transsulfuration and sulfur amino acid metabolism","description":"The top GO terms cluster around transsulfuration and sulfur amino acid biosynthesis, including L-serine catabolic process, hydrogen sulfide production, and cysteine biosynthesis via transsulfuration, plus several amino acid biosynthetic processes (serine, threonine, tryptophan). This points to proteins involved in sulfur-containing amino acid metabolism and related biosynthetic pathways, with a few outliers like response to morphine that are less representative. ","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006565","count":4},{"id":"GO:0070814","count":4},{"id":"GO:0019343","count":4},{"id":"GO:0019346","count":4},{"id":"GO:0043278","count":3}]},{"hash":"2273853661766950587","title":"Quinone biosynthesis and bacterial metabolism","description":"This cluster is dominated by GO terms for menaquinone and phylloquinone biosynthesis, pointing to quinone biosynthesis as a central theme. The presence of related catabolic paths (valine, fatty acid, phenylacetate) and antibiotic biosynthesis further suggests a broad bacterial metabolic cluster centered on quinone-related biosynthesis and energy/metabolic processes. ","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":8},{"id":"GO:0042372","count":8},{"id":"GO:0006574","count":8},{"id":"GO:0006635","count":8},{"id":"GO:0017000","count":8}]},{"hash":"670838532045152728","title":"Amino acid biosynthesis and related metabolism","description":"The top GO terms cluster around biosynthetic pathways for multiple amino acids (histidine, serine, lysine, methionine, glutamate) and related metabolism, plus biotin biosynthesis and antibiotic biosynthetic processes. While a few terms are obsolete or point to catabolic/oxidation-reduction activities, the overall pattern suggests a cohesive group of enzymes involved in amino acid and cofactor biosynthesis and related metabolism.","confidence":"Medium","size":8,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0019551","count":2},{"id":"GO:0006537","count":2},{"id":"GO:0009102","count":2}]},{"hash":"1044375648397506324","title":"Embryonic and sensory tissue morphogenesis","description":"The set is dominated by terms about embryonic development and morphogenesis across limbs, ears, and pattern formation, with related sensory system contexts (retina/pituitary). These point to a developmental program shaping tissue structure; metabolic terms are secondary.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035115","count":8},{"id":"GO:0042472","count":8},{"id":"GO:0042574","count":8},{"id":"GO:0009954","count":8},{"id":"GO:0007584","count":8}]},{"hash":"2215233756871415933","title":"Plant Carbon Metabolism and Photorespiration","description":"The top GO terms center on carbon- and nucleotide-based metabolism, including glycolate catabolism and photorespiration, along with GMP and purine nucleobase biosynthesis, and isoprenoid biosynthesis. These collectively indicate central metabolic and biosynthetic activities typical of plant carbon metabolism, with photorespiration being a notable theme. A couple of terms (retina development, interleukin-4 response) appear less related and may be noise. Overall, the cluster seems best described by plant metabolic pathways with a focus on photorespiration.","confidence":"Medium","size":8,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046296","count":7},{"id":"GO:0009854","count":7},{"id":"GO:0006144","count":7},{"id":"GO:0071353","count":7},{"id":"GO:0009853","count":7}]},{"hash":"1911841526702875307","title":"Sensory organ morphogenesis","description":"Several top terms point to development of sensory organs, with retina development and cochlea morphogenesis forming a cohesive theme. The presence of fibronectin fibril organization and tricellular tight junction assembly suggests extracellular matrix remodeling and barrier formation during morphogenesis. Additional inflammatory and protease-related terms may reflect remodeling and signaling processes accompanying organ development. Overall, the cluster appears to represent proteins involved in sensory tissue morphogenesis and ECM dynamics.","confidence":"Medium","size":8,"edges":12,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":3},{"id":"GO:0090103","count":3},{"id":"GO:0001935","count":3},{"id":"GO:1904274","count":3},{"id":"GO:1900017","count":3}]},{"hash":"1140107765241432890","title":"Embryonic Neural and Pituitary Development","description":"This cluster centers on embryogenesis and neural-endocrine differentiation, with genes involved in gastrulation, in utero development, neuron maturation, and pituitary gland development. Supporting terms about chromatin regulation and hormone biosynthesis align with developmental gene regulation and endocrine signaling, while some metabolic terms may reflect cofactors used in these processes. Overall, the dominant theme is embryonic neural and pituitary development.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0007369","count":3},{"id":"GO:0035563","count":3},{"id":"GO:0046098","count":3},{"id":"GO:0046886","count":3}]},{"hash":"503569240250313797","title":"Glucocorticoid Signaling and Stress Response","description":"The cluster shows explicit links to glucocorticoid pathways (nuclear receptor-mediated glucocorticoid signaling and glucocorticoid catabolic process) alongside apoptosis signaling and differentiation-related processes (keratinization, regulation of epidermal cell division, neuron migration). This combination suggests proteins functioning in glucocorticoid-regulated stress responses that influence cell fate decisions (survival vs. apoptosis) and differentiation, rather than a single narrow process.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006713","count":1},{"id":"GO:0008630","count":1},{"id":"GO:1900740","count":1},{"id":"GO:0010482","count":1},{"id":"GO:0043154","count":1}]},{"hash":"1255606599139613048","title":"Cardiac Morphogenesis and Transcription  ","description":"The enrichment includes transcription-related terms (RNA polymerase II\u2013mediated transcription, DNA-templated transcription) together with several cardiac development terms (atrium and left ventricle formation, valve development, outflow tract morphogenesis, aorta formation), suggesting proteins that coordinate transcriptional regulation with heart morphogenesis. A cortical interneuron differentiation term is less central but may reflect broader developmental regulation. Overall, the cluster appears to group transcriptional regulators involved in cardiac development.  ","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0006351","count":5},{"id":"GO:0045663","count":5},{"id":"GO:0061309","count":5},{"id":"GO:0035910","count":5}]},{"hash":"1276989526896621499","title":"Apoptosis and innate immune signaling","description":"These proteins cluster around programmed cell death and immune signaling: the top GO terms include apoptotic process, pyroptotic inflammatory response, and innate immune response, with supportive evidence from ubiquitination and related signaling (IL-7 response, Rho/Ras regulation). This suggests involvement in regulated cell death within immune contexts and inflammatory signaling.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0070269","count":5},{"id":"GO:0016567","count":5},{"id":"GO:1990001","count":5}]},{"hash":"1385492828746080373","title":"Embryonic and organ morphogenesis","description":"The top GO terms cover development and morphogenesis across multiple tissues (heart, hindlimb, placenta, gonads, prostate), suggesting a broad developmental role rather than a single tissue function. This shared theme supports naming the cluster Embryonic and organ morphogenesis.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014842","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0070328","count":4},{"id":"GO:0044320","count":4},{"id":"GO:0001890","count":3}]},{"hash":"643466988041408468","title":"Craniofacial and inner ear morphogenesis","description":"This cluster centers on developmental and morphogenetic processes affecting craniofacial and sensory structures, as shown by cochlea morphogenesis and roof of mouth development. Other terms hint at neural regulation, epithelial junctions, cytokine signaling, and proteolytic activation, suggesting proteins involved in tissue patterning and organ formation rather than a single narrow function.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090103","count":2},{"id":"GO:0002087","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1261804123975993903","title":"Diverse metabolite biosynthesis","description":"The Top Terms are dominated by biosynthetic and metabolic processes across a range of molecules (retinol, testosterone, glucocorticoids, melanin, antibiotics, retinal metabolism), suggesting a shared theme of production of diverse metabolites. Some terms (sporulation, lung development, redox) are more developmental or broad metabolic processes, indicating the cluster captures broad metabolic/biosynthetic activity rather than a single specific function. ","confidence":"Medium","size":8,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":2},{"id":"GO:0061370","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0017000","count":2}]},{"hash":"2174150548770287401","title":"Fatty acid metabolism and development","description":"The cluster centers on lipid metabolism, with fatty acid beta-oxidation (including medium-chain FA catabolic process) and carnitine-linked metabolism, plus steroid biosynthesis and lipid-derived signaling (ascaroside biosynthesis). The presence of liver development, cardiac muscle cell differentiation, and post-embryonic development suggests these lipid-related proteins may function in developing tissues, making a cohesive theme of lipid metabolism tied to organ development.","confidence":"Medium","size":8,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042594","count":2},{"id":"GO:0006694","count":2},{"id":"GO:0051793","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0001889","count":2}]},{"hash":"242944336781980347","title":"Nervous system development and myelination","description":"The top GO terms are dominated by neural development, including nervous system and peripheral nervous system development, myelination, and regulation of synapse assembly, plus Hedgehog signaling (smoothened pathway) and myogenesis terms that align with broader developmental processes. This combination points to a cluster involved in neural differentiation and myelin formation, with Hedgehog signaling supporting developmental roles. An outlier term about symbiont entry into host cells is likely noise relative to the main neural-development signal.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0051092","count":3},{"id":"GO:0007224","count":3},{"id":"GO:0045663","count":3},{"id":"GO:0051963","count":3}]},{"hash":"439050034385722742","title":"Coagulation-Associated Serine Proteases","description":"The terms point to proteolytic activation and regulation of serine-type endopeptidases, and to coagulation processes (zymogen activation, fibrin clot formation). Nearby terms describe extracellular matrix remodeling and vascular barrier dynamics (basement membrane disassembly, tricellular tight junction assembly, endothelial cell proliferation), which fits with serine protease\u2013driven coagulation and ECM remodeling in vessels. Some items (thyroid hormone response, inflammatory cytokine regulation, sodium homeostasis) are broader contextual signals, but the core signal is serine protease activity linked to coagulation.","confidence":"Medium","size":8,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016540","count":5},{"id":"GO:0097066","count":5},{"id":"GO:0001935","count":5},{"id":"GO:1904274","count":5},{"id":"GO:0034769","count":5}]},{"hash":"1227612236613023447","title":"Coagulation, fibrinolysis, and inflammatory signaling","description":"This cluster\u2019s top GO terms center on proteolytic cascades and immune/coagulation processes: complement activation (lectin pathway), plasminogen activation and fibrinolysis, and blood coagulation with fibrin clot formation. Additional terms reflect inflammatory signaling (interleukin-1 response) and angiogenesis, suggesting extracellular remodeling during inflammatory responses. Together these points indicate a coherent coagulation\u2013inflammation axis with related secretion and repair signals, even though a couple terms (UV-B response, NMJ axon regeneration) are less directly tied to this theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0007171","count":6},{"id":"GO:0031639","count":6},{"id":"GO:0045766","count":6},{"id":"GO:0042730","count":6}]},{"hash":"2087864024063481351","title":"Unknown","description":"Top GO terms are spread across immune-related processes (negative regulation of platelet aggregation; complement activation; adaptive immune response) and a variety of metabolic/developmental terms (retinal metabolic process, testosterone biosynthetic process, sporulation, melanin biosynthesis, antibiotic biosynthesis, lung development). The lack of a cohesive biological theme and the presence of only a single connection suggest these proteins do not share a single, interpretable function cluster. Therefore, Unknown","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090331","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0042574","count":1},{"id":"GO:0061370","count":1}]},{"hash":"1961937735476964449","title":"Developmental signaling and actin cytoskeleton remodeling","description":"The cluster shows prominent developmental-related GO terms (skin development, forebrain development, multicellular organism development) alongside regulators of the cytoskeleton (positive regulation of Arp2/3-mediated actin nucleation, GTPase activity, and tyrosine phosphorylation). This pattern suggests proteins involved in signaling that coordinates cell movements and morphology during development. While there are some broader terms (mRNA transport, hypoxia response), the core theme appears to be developmentally linked signaling coupled to actin remodeling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007568","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0007275","count":3}]},{"hash":"401309669363300280","title":"ER-Golgi trafficking and protein processing","description":"Top GO terms cluster around ER-Golgi vesicle transport (ER to Golgi, inter-Golgi), SNARE complex disassembly, and general protein processing, indicating a functional group dedicated to the secretory pathway and protein maturation; oxidative stress and ATP terms appear ancillary but can reflect cellular energy demands during trafficking.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048219","count":4},{"id":"GO:0061166","count":4},{"id":"GO:0016485","count":4},{"id":"GO:1903715","count":4},{"id":"GO:0034551","count":4}]},{"hash":"250876241862022615","title":"Developmental and Neuro-immune signaling","description":"The proteins are enriched for developmental terms (multicellular organism development, nervous system development, skeletal system development, myoblast differentiation) and immune-related regulation (innate immune response, NK cell cytotoxicity regulation, cytokine production). The mix of neural development, synapse assembly, and immune modulation suggests roles in development with neuro-immune signaling interactions, rather than a single, narrow pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0045663","count":5},{"id":"GO:0002859","count":5}]},{"hash":"2053229013207218213","title":"Mitochondrial lipid remodeling and energy production","description":"The cluster is dominated by lipid metabolism and mitochondrial energy-related terms: ether lipid biosynthesis, phosphatidylcholine and cardiolipin remodeling, triglyceride biosynthesis, and mitochondrial ATP synthesis with electron transport. While a few terms touch on tissue development or immune regulation, the central theme is mitochondrial lipid remodeling supporting ATP generation, suggesting a cohesive mitochondria-centered lipid metabolism module.","confidence":"High","size":8,"edges":10,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002071","count":5},{"id":"GO:0021587","count":5},{"id":"GO:0008611","count":5},{"id":"GO:0042775","count":5},{"id":"GO:0019432","count":5}]},{"hash":"2031644665817391229","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001782","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0035372","count":2},{"id":"GO:0043029","count":2}]},{"hash":"958009090976571766","title":"Cytokine-Mediated Immunoregulation","description":"The top GO terms cluster around modulation of immune signaling and cytokine production (e.g., GM-CSF, IL-3, IL-1\u03b1) and regulation of activation in macrophages and NK cells, indicating these proteins collectively participate in immune response modulation rather than a single developmental process. A neuron projection development term is present but likely incidental to the main theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050867","count":2},{"id":"GO:0045663","count":2},{"id":"GO:0050712","count":2},{"id":"GO:0043031","count":2},{"id":"GO:0002859","count":2}]},{"hash":"843102016318739926","title":"Ubiquitin-Dependent Protein Turnover and Endocytosis","description":"Dominant GO terms point to ubiquitin-mediated processes: K48-linked ubiquitination, ubiquitin-dependent protein catabolic process, and ubiquitin-dependent endocytosis. A few terms reference unrelated or obsolete roles, but the ubiquitin-related cluster is the strongest common theme among the listed proteins.","confidence":"High","size":8,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0046642","count":1},{"id":"GO:0070936","count":1},{"id":"GO:0003197","count":1},{"id":"GO:0019089","count":1},{"id":"GO:0050847","count":1}]},{"hash":"2047857056233177711","title":"Rho GTPase-driven cytoskeletal remodeling","description":"This cluster centers on regulation of Rho/small GTPase signaling and the assembly/remodeling of actin structures (filopodia) and related processes like cell spreading and adhesion. The presence of multiple GO terms tying to Rho signaling, filopodium assembly, and cytoskeletal dynamics suggests a cohesive theme of cytoskeletal remodeling governed by Rho-family GTPases, with auxiliary connections to membrane dynamics and secretion. The GABAergic synaptic term is present but seems less central to the core theme than the cytoskeletal signals.","confidence":"High","size":8,"edges":9,"triangles":0,"max_degree":5,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0045792","count":6},{"id":"GO:0051489","count":6},{"id":"GO:0051932","count":6},{"id":"GO:0046847","count":6}]},{"hash":"242263061247722491","title":"Developmental signaling and morphogenesis regulators","description":"The cluster\u2019s GO terms cluster around developmental signaling (notably BMP signaling), embryonic morphogenesis (e.g., caudal fin morphogenesis), axis specification, and reproductive/developmental processes (polyspermy prevention, sperm-egg interactions). Additional terms on proteolysis and muscle growth regulation suggest remodeling and growth control during development, and mitochondrial permeability relates to cellular regulation during developmental events. Overall, these terms point to proteins involved in developmental signaling and tissue morphogenesis across species. Confidence: Medium","confidence":"","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030513","count":2},{"id":"GO:2000360","count":1},{"id":"GO:0018996","count":1},{"id":"GO:0060468","count":1},{"id":"GO:0035124","count":1}]},{"hash":"398626353987234070","title":"Hippo and Wnt signaling in epithelial growth control","description":"The cluster is enriched for Hippo signaling and Wnt pathway terms, along with mitotic/meiotic cell cycles, apoptosis, keratinocyte differentiation, and mechanotransduction-related processes like response to muscle stretch and cell\u2013matrix adhesion. This combination suggests a cohesive module regulating proliferation, survival, and differentiation in epithelial (skin-like) contexts, influenced by mechanical cues and cytoskeletal interactions.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035329","count":4},{"id":"GO:0001954","count":4},{"id":"GO:0060044","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0000278","count":4}]},{"hash":"827935729184912941","title":"Hormone and xenobiotic metabolism with sulfation","description":"The top GO terms cluster around hormone metabolism (estrogen catabolic, angiotensin regulation, catecholamine metabolism) and sulfation-related processes (peptidyl-tyrosine sulfation, sulfate assimilation, GAG sulfation), plus xenobiotic and bile acid metabolism. While there are a few outlier development terms, the dominant pattern suggests a metabolic/modification role related to hormones, sulfated molecules, and xenobiotics.","confidence":"Medium","size":8,"edges":11,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006711","count":3},{"id":"GO:0002002","count":3},{"id":"GO:0006584","count":3},{"id":"GO:0000103","count":3},{"id":"GO:0006478","count":3}]},{"hash":"1817572983692293298","title":"Neuronal signaling and brain function","description":"The top GO terms center on neurotransmission and neural development, including acetylcholine receptor signaling, GABA receptor clustering, dopamine secretion, innervation, and brain-related processes (lateral geniculate nucleus development, adult walking behavior, heart rate regulation via baroreceptors). Sodium ion transmembrane transport supports neuronal excitability, aligning with a theme of neural signaling and brain function. A couple of outliers (complement activation, insecticide response) are present but do not override the predominant neural theme.","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0021771","count":2},{"id":"GO:0097112","count":2},{"id":"GO:0001988","count":2},{"id":"GO:0035725","count":2}]},{"hash":"1107234712481375427","title":"Neural signaling and innervation","description":"The top GO terms point to neural development and synaptic function\u2014optic nerve morphogenesis and LGN development indicate visual pathway development; GABA and acetylcholine receptor signaling, along with dopamine secretion, reflect neurotransmission; innervation and ion transport support neuronal activity, with some terms touching autonomic functions like heart rate and micturition, all converging on neural signaling and nerve innervation.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0021771","count":2},{"id":"GO:0097112","count":2},{"id":"GO:0001988","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0095500","count":2}]},{"hash":"294024489428885799","title":"Spliceosome and RNA Processing Machinery","description":"The terms cluster around RNA processing and splicing (spliceosome, snRNP and complex assembly), along with rRNA and tRNA maturation and P-body\u2013related mRNA metabolism, indicating a cohesive RNA-manufacturing/processing module.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":7},{"id":"GO:0030490","count":5},{"id":"GO:0070317","count":5},{"id":"GO:0033962","count":5},{"id":"GO:0000387","count":5}]},{"hash":"478371533857442642","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0035206","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0010923","count":1}]},{"hash":"1129066891788457609","title":"Nucleocytoplasmic transport and nuclear pore assembly","description":"The terms are dominated by nucleocytoplasmic transport processes: mRNA export from the nucleus, various forms of protein import into the nucleus, ribosomal protein import, and nuclear pore complex assembly. Additional signals like tRNA transport and NLS-bearing protein import reinforce a cohesive theme of nuclear trafficking. Some regulation-oriented terms appear, but the core cluster appears to center on transport into/within the nucleus.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006406","count":5},{"id":"GO:0042176","count":5},{"id":"GO:0000060","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0051292","count":5}]},{"hash":"1952205245749475251","title":"Immune and neural development","description":"The cluster shows a mix of immune-related terms (activated T cell proliferation, NK T cell differentiation, hemopoiesis) and neural development terms (axonogenesis, motor neuron fasciculation, dendritic spine morphogenesis), with a shared reference to Rho signaling. It also touches on placental development, reinforcing a broad developmental theme across tissues rather than a single, cohesive pathway. Confidence in a tight, singular function is moderate due to the diverse terms, but it coherently labels a developmental/differentiation cluster spanning immune and neural contexts.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050798","count":3},{"id":"GO:0060709","count":3},{"id":"GO:0021952","count":3},{"id":"GO:0097156","count":3},{"id":"GO:0007266","count":3}]},{"hash":"1242888299879333122","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0000349","count":2},{"id":"GO:1990416","count":2}]},{"hash":"139011083841438691","title":"Ubiquitination and Immune Regulation","description":"Most terms point to ubiquitin biology, including protein ubiquitination, K48-linked ubiquitination, and ubiquitin-dependent proteolysis, suggesting a ubiquitin\u2013proteasome\u2013mediated turnover module. Immune-related terms (adaptive immune response, T cell homeostasis) imply this pathway interfaces with immune regulation, while negative regulation of RIG-I signaling and vitamin D response provide context for signaling cross-talk.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0039536","count":4},{"id":"GO:0033280","count":4},{"id":"GO:0002250","count":4}]},{"hash":"799677736347347998","title":"Integrin Signaling and Cytoskeletal Remodeling","description":"The GO terms cluster around integrin-mediated adhesion and signaling, regulation of stress fiber assembly, cell morphology, and polarity establishment, indicating a shared role in cytoskeletal remodeling and adhesion processes. While there are peripheral terms related to DNA replication and galactose-responsive transcription, the dominant theme is integrin-associated signaling and cytoskeletal dynamics.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042220","count":3},{"id":"GO:0051492","count":3},{"id":"GO:0008285","count":3},{"id":"GO:2000114","count":3},{"id":"GO:0006260","count":3}]},{"hash":"1778544480203812791","title":"RNA processing and translation initiation regulation","description":"These proteins are enriched for GO terms related to mRNA splicing via the spliceosome, mRNA export, splicing site recognition, mRNA modification, regulation of mRNA stability during stress, and regulation of translational initiation/preinitiation complex formation, indicating a cohesive role in RNA maturation and control of translation. ","confidence":"High","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0002188","count":3},{"id":"GO:0016556","count":3},{"id":"GO:1901407","count":3}]},{"hash":"1168294217324955800","title":"Neural development with inflammatory and vascular cues","description":"The terms cluster around nervous system development and axon guidance (in utero embryonic development; trigeminal ganglion development; vestibulocochlear nerve structural organization) and also include immune/vascular processes (complement activation via lectin and alternative pathways; sprouting angiogenesis; VEGF-related signaling). This suggests a cohesive theme of neural development influenced by inflammatory and vascular signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0048843","count":2},{"id":"GO:1902946","count":2},{"id":"GO:1900017","count":2},{"id":"GO:1902378","count":2}]},{"hash":"865073946337519622","title":"Spindle assembly and microtubule dynamics","description":"This cluster centers on microtubule-based processes, especially spindle assembly and dynamics. Terms such as mitotic spindle elongation, plus-end depolymerization, kinetochore attachment, and meiotic spindle orientation point to a shared function in organizing microtubules during cell division. The remaining terms touch on structural roles linked to microtubules in stem cells and neurons, but the dominant theme remains microtubule dynamics.","confidence":"High","size":7,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032886","count":7},{"id":"GO:0000742","count":7},{"id":"GO:0036334","count":7},{"id":"GO:0000022","count":7},{"id":"GO:0070462","count":7}]},{"hash":"1834921809160032652","title":"Bacterial metabolism and stress response","description":"The terms cluster around metabolic processes (L-alanine and D-galactarate catabolism) and vitamin B6 biosynthesis, alongside environmental response pathways (response to nutrient, hypoxia, lipopolysaccharide) and sporulation. This points to a theme of metabolic adjustment coupled with stress/environmental response in bacteria, despite some noisy or obsolete GO entries. ","confidence":"Medium","size":7,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0007584","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0032496","count":3}]},{"hash":"802425649083639217","title":"Antigen presentation and immune signaling","description":"The terms show a clear cluster around antigen processing/presentation via MHC I (including TAP-related steps) and multiple immune signaling pathways (TNF, Fc-epsilon receptor, T cell receptor, and C-type lectin receptor signaling). Ubiquitin-proteasome-related activities (deubiquitination and proteasome assembly) support antigen processing, tying degradation with presentation. A few metabolic and stress terms are present but the dominant theme is immune signaling and antigen presentation.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0080129","count":4},{"id":"GO:0002479","count":4},{"id":"GO:0033209","count":4},{"id":"GO:0038095","count":4}]},{"hash":"250549850933643333","title":"Flavonoid and anthocyanin biosynthesis","description":"The GO terms are dominated by anthocyanin-containing compound biosynthetic process, kaempferol O-glucoside biosynthetic process, cyanidin 3-O-glucoside biosynthetic process, and general flavonoid biosynthesis, indicating a cluster of proteins involved in flavonoid pigment production and related phytoestrogen responses. Some terms appear peripheral or obsolete, but the central theme is flavonoid biosynthesis.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0006711","count":3},{"id":"GO:0033330","count":3},{"id":"GO:0070980","count":3}]},{"hash":"1890684687234917494","title":"Neural perception and drug-response signaling","description":"The dominant GO terms point to neural processing and behavior: visual perception and learning, dopaminergic synaptic transmission, sensory pain perception, and behavioral responses to morphine and cocaine, with ERK signaling and prostaglandin-related modulation. While a couple of terms (heart development, macrophage chemotaxis) are peripheral, the core theme is neural sensory processing and addiction-related signaling.","confidence":"Medium","size":7,"edges":16,"triangles":16,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0010759","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0071380","count":6},{"id":"GO:0043278","count":6}]},{"hash":"1858873613166365434","title":"Integrin signaling, ECM remodeling, and angiogenesis","description":"This cluster is dominated by GO terms for integrin-mediated signaling and cell-matrix adhesion, plus hyaluronan metabolism and positive regulation of metallopeptidase activity, which together point to extracellular matrix remodeling. The inclusion of angiogenesis and multicellular growth terms reinforces a tissue remodeling/vascularization theme, with some inflammatory signals present as secondary context. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":6},{"id":"GO:0030212","count":6},{"id":"GO:1905050","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0007160","count":5}]},{"hash":"118835037091570006","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030420","count":4},{"id":"GO:0031126","count":3},{"id":"GO:0034247","count":3},{"id":"GO:0034414","count":3},{"id":"GO:0046677","count":3}]},{"hash":"1852672624555179114","title":"Developmental and Neural-Immune Signaling","description":"The top GO terms span developmental programs (axial mesoderm formation, myoblast differentiation, ovulation cycle) and neural maturation (synapse assembly, dendrite development), plus immune-related modulation (positive regulation of T cell costimulation, negative regulation of lymphangiogenesis). There is also a general cell spreading/adherence term. Overall, the cluster seems to reflect signaling networks coordinating development with neural and immune processes, rather than a single narrow function. One outlier term (chitin catabolic process) likely reflects annotation noise or a broader multifunctionality, but does not negate the overall theme. ","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":7},{"id":"GO:0045663","count":7},{"id":"GO:0042698","count":7},{"id":"GO:0048320","count":7},{"id":"GO:0051965","count":7}]},{"hash":"1662690471360829384","title":"Unknown","description":"The GO terms span a broad set of processes including development (axial mesoderm formation, myoblast differentiation, dendrite/synapse development), reproduction (ovulation cycle), immune signaling (T cell costimulation, lymphangiogenesis), and even chitin catabolism and endosome trafficking. There isn't a single cohesive function tying these together, indicating heterogeneous roles rather than a unified cluster.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":7},{"id":"GO:0045663","count":7},{"id":"GO:0042698","count":7},{"id":"GO:0048320","count":7},{"id":"GO:0051965","count":7}]},{"hash":"1419183888960605414","title":"Embryonic development and vascular patterning","description":"This cluster centers on embryogenesis and morphogenesis, highlighted by terms for single fertilization, multicellular development, embryonic heart tube left/right patterning, and endothelial cell delamination plus cell-matrix adhesion, suggesting a focus on development and vascular remodeling. The immune and metabolic terms appear less central to the core theme, so the label reflects the dominant developmental/vascular signal.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0060971","count":3},{"id":"GO:0001867","count":2},{"id":"GO:0007160","count":2}]},{"hash":"1622142859298893019","title":"Unfolded Protein Response and Chaperone Activity","description":"Reason: The cluster is enriched for terms related to protein folding stress and quality control, including cellular response to unfolded protein, chaperone-related refolding (even if obsolete), and post-translational targeting to membranes, along with stress responses to heat and oxidative conditions. These points collectively suggest involvement in protein quality control under stress, i.e., unfolded protein response and chaperone activity.","confidence":"Medium","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090084","count":5},{"id":"GO:0000902","count":5},{"id":"GO:0000742","count":5},{"id":"GO:0006260","count":5},{"id":"GO:1903751","count":5}]},{"hash":"228710356091799973","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0045921","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0019878","count":1}]},{"hash":"1410700412996693534","title":"Immune Defense and Transcription Regulation","description":"The top GO terms cluster around immune defense (virus and protozoan responses, interferon production, B cell homeostasis) and transcriptional regulation (DNA-templated transcription and chromatin-related regulation), suggesting proteins involved in immune signaling that also modulate gene expression.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051607","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0042832","count":3},{"id":"GO:0032729","count":3},{"id":"GO:0071260","count":3}]},{"hash":"36929816076307948","title":"Nervous system development and dendrite morphogenesis","description":"The set centers on nervous system development, hippocampus development, and dendrite morphogenesis, with related terms for excitatory synaptic activity and signaling pathways (JNK/cytoskeletal regulation). This points to a cohesive theme of neuronal differentiation and dendrite/axon morphogenesis and synaptic maturation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":7},{"id":"GO:0021766","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0033138","count":7},{"id":"GO:0048813","count":7}]},{"hash":"798077672475678728","title":"ER Stress and Redox-Driven Transcription","description":"This cluster combines DNA-templated transcription and positive regulation of DNA binding with oxidative stress response and ER protein folding, suggesting a coordinated program where redox status and ER stress influence transcriptional regulation; obsolete terms and a mitochondrial-related term may reflect annotation noise but do not override the main theme.","confidence":"Medium","size":7,"edges":14,"triangles":12,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0034599","count":5},{"id":"GO:0006662","count":5},{"id":"GO:0034975","count":5},{"id":"GO:0033158","count":5}]},{"hash":"1450993289401631153","title":"Rho GTPase\u2013Mediated Actin Cytoskeleton Assembly","description":"This cluster centers on actin cytoskeleton remodeling, with terms for lamellipodium, filopodium, microspike, and stress fiber assembly, all tied to Rho GTPase signaling and activation. A few terms hint at unrelated processes (dendritic cell chemotaxis, growth hormone secretion), but the dominant theme is Rho-driven actin structure assembly.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0030032","count":3},{"id":"GO:1904424","count":3},{"id":"GO:0002408","count":3}]},{"hash":"1619486929054707196","title":"Cerebellar neural development and axonogenesis","description":"The term set centers on cerebellar-associated processes (cerebellar cortex formation, Bergmann glial differentiation) and neural outgrowth (axonogenesis, axon regeneration), with glial involvement (Schwann cell development) and neural maturation (dendritic spine regulation). These collectively point to cerebellar neural development and axon growth, while some immune/metabolic terms may be peripheral. ","confidence":"Medium","size":7,"edges":8,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048679","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0060020","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0061000","count":3}]},{"hash":"971794006663582126","title":"Neuromuscular junction organization","description":"This cluster is dominated by terms for synaptic assembly at the neuromuscular junction and related membrane organization (postsynaptic and presynaptic), suggesting proteins involved in NMJ formation and synaptic membrane organization. Other terms about adhesion and development are present but secondary to the NMJ synaptic assembly theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051124","count":3},{"id":"GO:0010811","count":3},{"id":"GO:0060976","count":2},{"id":"GO:0097104","count":2},{"id":"GO:0044332","count":2}]},{"hash":"262862354464005537","title":"Cell death and innate immune signaling","description":"The top terms cluster around regulated cell death (apoptosis, pyroptosis) and innate immunity, with ubiquitination often regulating these pathways. While there are some outliers related to mitosis and extracellular matrix, the dominant theme is death-related and immune signaling processes. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0070269","count":3},{"id":"GO:0016567","count":3},{"id":"GO:1990001","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1361647520985313816","title":"Hormone and Xenobiotic Metabolism","description":"The prominent GO terms point to catabolic and metabolic processes for hormones and xenobiotics: estrogen catabolic process, bile acid catabolic process, catecholamine metabolic process, and xenobiotic metabolic process, along with regulation of angiotensin levels. This suggests a cohesive function in hormone/homeostasis and detoxification. Some terms (sulfate assimilation, glycosaminoglycan biosynthesis) are less aligned or likely represent annotation noise, and a developmental term (embryonic neurocranium morphogenesis) appears as an outlier.","confidence":"Medium","size":7,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":6},{"id":"GO:0030206","count":6},{"id":"GO:0006711","count":5},{"id":"GO:0002002","count":5},{"id":"GO:0006584","count":5}]},{"hash":"2198496307698028071","title":"Glycosphingolipid and N-glycan metabolism in neural development","description":"The top GO terms converge on glycan and glycosphingolipid pathways (N-glycan processing, oligosaccharide metabolism, N-acetylneuraminate metabolism, glycosylceramide, ganglioside biosynthesis), with supporting neural/olfactory development terms (olfactory nerve formation, olfactory placode morphogenesis). This suggests a cohesive theme of cell-surface glyco-lipid remodeling relevant to neural tissues, despite some unrelated pollen terms possibly reflecting annotation noise.","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006054","count":2},{"id":"GO:0009846","count":2},{"id":"GO:0018279","count":2},{"id":"GO:0021628","count":2},{"id":"GO:0009311","count":2}]},{"hash":"448311560884934626","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0035372","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0007014","count":5},{"id":"GO:0061158","count":5},{"id":"GO:0051092","count":5}]},{"hash":"1083282535395489153","title":"Neuronal mitochondrial quality control","description":"Several top GO terms point to mitochondrial processes (negative regulation of ROS, regulation of mitophagy, protein import into the mitochondrial matrix) and neural functions (synaptic transmission, learning, fear behavior). This suggests a theme of maintaining mitochondrial function within neural contexts, i.e., mitochondrial quality control in neurons. Other terms likely reflect broader developmental roles but do not define a distinct alternative theme.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":1},{"id":"GO:0030855","count":1},{"id":"GO:1903146","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0007612","count":1}]},{"hash":"1039424805235388755","title":"Immune Activation and Cytokine Production","description":"The top GO terms cluster around immune signaling: regulation and production of cytokines such as IL-3 and GM-CSF, and T cell activation (proliferation), with an additional innate immune cue (response to LPS). While there are some outliers related to unrelated processes, the dominant themes point to immune cell activation and inflammatory signaling.","confidence":"Medium","size":7,"edges":12,"triangles":6,"max_degree":6,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":7},{"id":"GO:0045401","count":7},{"id":"GO:0045425","count":7},{"id":"GO:0071222","count":7},{"id":"GO:2000811","count":7}]},{"hash":"497271593651857548","title":"Endothelial inflammation and ECM remodeling","description":"Top GO terms cluster around endothelial biology (endothelial proliferation, tight junction assembly), inflammation (acute inflammatory response, cytokine production regulation, integrin signaling), and extracellular matrix dynamics (fibronectin fibril organization). This points to a coherent theme of vascular barrier function during inflammation and ECM remodeling, with some broader terms like zymogen activation and protein oligomerization contributing but not overriding the core signal. Confidence: Medium","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":4},{"id":"GO:1904274","count":4},{"id":"GO:1900017","count":4},{"id":"GO:0031638","count":4},{"id":"GO:0018057","count":4}]},{"hash":"711111935864077193","title":"P-body/mRNA regulation","description":"The top GO terms are dominated by P-body assembly and regulation of cytoplasmic mRNA processing bodies, along with negative regulation of miRNA-mediated gene silencing. These point to a core function in RNA processing regulation and mRNA silencing via P-bodies, even though additional developmental terms appear, they seem peripheral to the central theme. Therefore, the cluster is best labeled as P-body/mRNA regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060965","count":1},{"id":"GO:0033962","count":1},{"id":"GO:0042051","count":1},{"id":"GO:0002091","count":1},{"id":"GO:0009994","count":1}]},{"hash":"569157434883337196","title":"Chromatin remodeling and transcription regulation","description":"The top GO terms cluster around chromatin dynamics and control of transcription, including nucleosome assembly, chromatin remodeling, and negative regulation of transcription by RNA polymerase II, plus transcription initiation at the mitochondrial promoter and a note on spermatid nucleus differentiation. This points to a shared theme of regulating gene expression through chromatin structure and transcriptional control, with a germ-cell differentiation angle and some peripheral or obsolete terms. Overall, a coherent chromatin- and transcription-focused cluster is most plausible.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006334","count":2},{"id":"GO:0007289","count":2},{"id":"GO:0006391","count":2},{"id":"GO:0043044","count":2}]},{"hash":"962379134429660014","title":"Angiogenesis and endothelial signaling","description":"The cluster centers on positive regulation of angiogenesis and endothelial cell proliferation, with related signaling pathway terms (MAPK cascade and PI3K/AKT signaling) suggesting a vascular development and endothelial signaling role. A couple of terms about membrane organization and other housekeeping processes appear auxiliary but do not override the main theme.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016321","count":1},{"id":"GO:0071763","count":1},{"id":"GO:0043410","count":1},{"id":"GO:0045766","count":1},{"id":"GO:0001938","count":1}]},{"hash":"145098594961377893","title":"Multisystem signaling and trafficking","description":"The proteins in this cluster show GO terms spanning immune signaling (interferon responses, biotic stimulus), neuronal and motor function (synaptic vesicle clustering, neuromuscular posture), metabolic signaling (glucose import in response to insulin), intracellular trafficking (endosome to plasma membrane transport), and development (bone morphogenesis/mineralization). This breadth suggests a shared theme around signaling across multiple systems and vesicular transport rather than a single, cohesive pathway, hence a multisystem signaling/trafficking label.","confidence":"Low","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":2},{"id":"GO:0035455","count":2},{"id":"GO:0050884","count":2},{"id":"GO:0097091","count":2},{"id":"GO:0046597","count":2}]},{"hash":"1715313081391779731","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0019062","count":1},{"id":"GO:0036265","count":1}]},{"hash":"789469950149696785","title":"Histone acetylation and chromatin modification","description":"This cluster prominently features GO terms for histone acetylation (H3/H4 acetylation) and related chromatin regulation, suggesting proteins involved in epigenetic control of gene expression. While some terms pertain to development or signaling, the strongest shared function among the terms is histone modification.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0043981","count":2},{"id":"GO:0072520","count":2}]},{"hash":"229016949538351874","title":"Embryonic and Neural Development","description":"The top GO terms cluster around embryogenesis and neural development (skeletal system development, multicellular organism development, forebrain development, neural tube closure), indicating a cohesive role in development and neural patterning, despite a few translation-related terms that are less central to the cluster\u2019s primary function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0032436","count":2}]},{"hash":"273449685216688000","title":"DNA Damage Response and Chromatin Remodeling","description":"The key terms point to genome maintenance: transcription-coupled nucleotide-excision repair (NER), synthesis-dependent strand annealing for double-strand break repair, and the SOS response, all implying a DNA damage response. Chromatin remodeling and transcriptional regulation terms further suggest that these repair activities occur within a chromatin context. A noisy, unrelated GO term like associative learning appears to be an annotation artifact. Overall, the cluster centers on DNA damage response intertwined with chromatin dynamics.","confidence":"Medium","size":6,"edges":7,"triangles":4,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0008306","count":6},{"id":"GO:0006283","count":5},{"id":"GO:0045003","count":5},{"id":"GO:0042273","count":5},{"id":"GO:0043044","count":5}]},{"hash":"151499332528900288","title":"Developmental transcription and morphogenesis","description":"Top terms indicate developmental processes (adult somatic muscle development; tracheal system branching/morphogenesis) alongside transcriptional regulation (DNA-templated transcription and its positive regulation). This points to a theme of developmental gene regulation driving morphogenesis, rather than a single enzymatic pathway. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007527","count":2},{"id":"GO:2001172","count":2},{"id":"GO:0090180","count":2},{"id":"GO:1903212","count":2},{"id":"GO:1904799","count":1}]},{"hash":"157320443888148948","title":"Neural development and signaling with cell cycle regulation","description":"The GO terms show a clear emphasis on nervous system development, hippocampus development, and excitatory synaptic signaling, pointing to neural development and synaptic function as the core theme. There are some mitotic cell cycle annotations, but they are less central to the cluster\u2019s main signal. Overall, it seems to capture proteins involved in brain development and neuronal signaling with some cell cycle connections.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0050771","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0021766","count":3}]},{"hash":"2219091963033398472","title":"Unknown","description":"The GO terms are heterogeneous, including fatty acid biosynthesis, metabolism of selenium and pyridoxine, liver and heart development, sporulation, and host cell entry, with no clear shared function or pathway linking the proteins. The lack of edges further supports the absence of a cohesive cluster function.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042759","count":2},{"id":"GO:1902321","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1458930565224546527","title":"Retroviral entry and proviral integration","description":"The top GO terms cluster around retroviral processes: viral penetration into the host nucleus, RNA-templated DNA biosynthesis (reverse transcription), DNA replication and recombination, DNA integration, and establishment of integrated proviral latency. These collectively point to proteins involved in retroviral infection and proviral genome integration into the host genome, with latency as a key aspect. Confidence: High","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0015074","count":3}]},{"hash":"1511112929672130863","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0042542","count":2},{"id":"GO:0051775","count":2},{"id":"GO:0009749","count":2},{"id":"GO:0006458","count":2}]},{"hash":"1020621472850868866","title":"Secretory vesicle trafficking in organ development","description":"The terms emphasize COPII coating and ER-to-Golgi transport, autophagy, and secretion processes, along with morphogenesis of the aorta, pulmonary artery, and lung. This points to a theme of secretory/trafficking activities that support organ development and lumen formation, rather than a single isolated function. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048208","count":1},{"id":"GO:0035909","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0016236","count":1},{"id":"GO:2000189","count":1}]},{"hash":"836828720156748352","title":"Thermoregulation and catecholamine cardiovascular response","description":"Based on the top GO terms, the strongest shared theme is heat-related processes (cellular response to temperature stimulus, diet-induced thermogenesis, heat generation) together with catecholamine-driven cardiovascular effects (vasoconstriction and heart rate regulation by epinephrine/norepinephrine). Although some terms relate to pain perception and chemokine signaling, the core cluster appears to center on thermoregulation and sympathetic signaling affecting cardiovascular function, justifying this label. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0060658","count":4},{"id":"GO:0035106","count":4}]},{"hash":"807384908266382614","title":"Membrane Ion and Substrate Transporters","description":"The top GO terms are dominated by various transmembrane transport activities for ions (sodium, potassium, phosphate) and a range of small molecule substrates (sialic acid, urate, arabinose, 4-hydroxyphenylacetate), plus a vesicular neurotransmitter loading term. This pattern points to a cluster of proteins whose primary function is transport across membranes, rather than enzymes or receptors, justifying a concise label that captures the broad transporter theme.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0098700","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0015747","count":3}]},{"hash":"1065801451770649080","title":"Developmental transcription and differentiation","description":"The GO terms include DNA-templated transcription and several development-related processes across different tissues (forebrain, pituitary, chorionic trophoblast, spermatid differentiation, and meiosis), indicating the proteins may be transcriptional regulators coordinating developmental programs rather than a single tissue pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0048515","count":1},{"id":"GO:0040027","count":1}]},{"hash":"271228658331213160","title":"Negative Regulators of Innate Immune Signaling","description":"This cluster is dominated by GO terms describing negative regulation of key innate immune pathways (TLR9 signaling, IL-6 production, interferon-alpha production, and NOD2 signaling), plus related processes like receptor catabolic regulation and endothelial barrier maintenance. While there is one term indicating positive regulation of TLR9 signaling, the overall pattern points to proteins that dampen inflammatory signaling and modulate immune-barrier functions, suggesting a coherent role as regulators of innate immunity.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034165","count":6},{"id":"GO:1900165","count":6},{"id":"GO:1903898","count":6},{"id":"GO:0032687","count":6},{"id":"GO:0090557","count":6}]},{"hash":"996591464956751140","title":"Flavonoid glycoside biosynthesis","description":"The top GO terms are dominated by flavonoid-related glycoside biosynthesis, including anthocyanin-containing, kaempferol O-glucoside, cyanidin 3-O-glucoside, and quercetin O-glucoside biosynthetic processes. This points to a coherent theme of producing flavonoid glycosides/pigments, despite some noisy terms present. Confidence in this label is high due to the clear clustering around flavonoid glycoside biosynthesis.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":3},{"id":"GO:0006711","count":2},{"id":"GO:0033330","count":2},{"id":"GO:0070980","count":2},{"id":"GO:0002175","count":2}]},{"hash":"466064488938863476","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009699","count":5},{"id":"GO:0009242","count":5},{"id":"GO:0009718","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0042351","count":5}]},{"hash":"111403025745392571","title":"Cytoskeleton and cell polarity","description":"This cluster centers on actin/cytoskeleton dynamics and cell shape/migration, with GO terms for cell polarity, mesenchyme migration, actin cortical patch localization, and muscle thin filament assembly, plus mitochondrial localization. These together suggest roles in cytoskeletal organization and cell movement; a few obsolete histone acetylation terms appear as legacy annotations rather than core functions.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071963","count":5},{"id":"GO:0090131","count":5},{"id":"GO:0043983","count":5},{"id":"GO:0051666","count":5},{"id":"GO:1904623","count":5}]},{"hash":"1807236902454367304","title":"Carbohydrate and polyol catabolism","description":"This cluster is best described by the prevalence of sugar-alcohol related catabolic processes in the GO terms, such as D-sorbitol catabolic process and xylitol catabolic process, along with other carbohydrate- and aldehyde-metabolizing activities (furaldehyde metabolic process, ethanol oxidation). While some terms seem unrelated (e.g., anthocyanin biosynthetic process, respiratory system process, blood pressure regulation), the strongest signal points to carbohydrate and polyol metabolism and associated redox reactions. Therefore, the label Carbohydrate and polyol catabolism captures the core theme of this cluster.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0009718","count":3},{"id":"GO:0003016","count":2},{"id":"GO:0051160","count":2},{"id":"GO:0051409","count":2}]},{"hash":"1240035906997866487","title":"Actin Cytoskeleton Remodeling","description":"This cluster is dominated by GO terms for actin filament depolymerization and its negative regulation, pointing to actin cytoskeleton remodeling as the core function. Other terms touch on neuronal projection and signaling, which often involve cytoskeletal changes, but the strongest signal is actin dynamics. Note that several terms are deprecated, suggesting some noise, but the central theme remains actin remodeling.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":3},{"id":"GO:0030579","count":3},{"id":"GO:0007369","count":2},{"id":"GO:0016575","count":2},{"id":"GO:0043046","count":2}]},{"hash":"308513719530177089","title":"Small-molecule biosynthesis","description":"The top GO terms point to diverse biosynthetic pathways (biotin, menaquinone, antibiotics, strigolactones) and related metabolic/catabolic processes, suggesting a broad metabolic biosynthesis theme rather than a single specific function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:1901601","count":1},{"id":"GO:0097755","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0055114","count":1}]},{"hash":"2173886485440895922","title":"Melanocyte pigmentation and sensory signaling","description":"It centers on pigment-related biology (developmental pigmentation, regulation of melanocyte differentiation) and sensory signaling (blue light signaling, taste perception, dopamine receptor signaling), with supporting roles in GPCR pathways and cellular organization, suggesting a theme around pigment development linked to sensory signaling contexts.","confidence":"Medium","size":6,"edges":10,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048066","count":4},{"id":"GO:0001889","count":4},{"id":"GO:0097212","count":4},{"id":"GO:0045634","count":4},{"id":"GO:0050917","count":4}]},{"hash":"2242853227632371231","title":"Rho GTPase Signaling","description":"The cluster is dominated by GO terms for positive regulation of GTPase activity and Rho/small GTPase\u2013mediated signal transduction, pointing to a core function in Rho GTPase signaling pathways; related terms like exocytosis and various developmental processes are common downstream or contextual roles for these pathways across organisms.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0001501","count":6},{"id":"GO:0007266","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007124","count":6}]},{"hash":"1848460482832582486","title":"Unknown","description":"The GO terms are highly diverse (transcriptional regulation and RNA splicing alongside lipopolysaccharide response, sterol biosynthesis, cytolysis, and developmental processes), with no single clear common function binding all proteins. Because there isn\u2019t a cohesive dominant theme, this cluster is best labeled Unknown.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0021983","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0019835","count":2}]},{"hash":"1317494483678092213","title":"Ubiquitin-proteasome\u2013mediated cell cycle and DNA repair","description":"The cluster is enriched for SCF-dependent ubiquitin-proteasomal degradation, K48-linked ubiquitination, and key mitotic events (G2/M transition, exit from mitosis, chromosome segregation), plus DNA damage response signals (nucleotide excision repair, mitotic DNA damage checkpoint). This suggests a cohesive theme of regulated protein turnover coordinating cell cycle progression and genome maintenance, with a possible incidental viral-process annotation.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031146","count":6},{"id":"GO:0016032","count":6},{"id":"GO:0000086","count":6},{"id":"GO:0070911","count":6},{"id":"GO:0010458","count":6}]},{"hash":"1302014147997881948","title":"Polyol Catabolism and PPP Metabolism","description":"The terms cluster around metabolism of sugar alcohols (sorbitol, xylitol) and intermediates of the pentose phosphate pathway (D-xylulose 5-phosphate biosynthesis), with related carbohydrate biosynthesis (fructose) and furaldehyde metabolism. While some terms like respiratory system process and blood pressure regulation appear, the dominant theme is polyol catabolism linked to PPP-related sugar metabolism, supporting this label as representative of the cluster\u2019s function.","confidence":"Medium","size":6,"edges":6,"triangles":2,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003016","count":2},{"id":"GO:0051160","count":2},{"id":"GO:0051409","count":2},{"id":"GO:0006062","count":2},{"id":"GO:0045777","count":2}]},{"hash":"2155201594301708464","title":"Stress-induced apoptosis and metabolic catabolism","description":"The cluster features apoptotic process and cytolysis terms, pointing to cell death pathways, while several catabolic processes (glycerol, guanine, dopamine, betaine) imply metabolic remodeling. Additional terms for metal-ion responses (aluminum, selenium) indicate stress signaling. Together, these suggest a theme of stress-related cell death coupled with metabolic changes, justifying a label centered on apoptosis and metabolism under stress.","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0019835","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0010044","count":3},{"id":"GO:0019563","count":3}]},{"hash":"826088720622699632","title":"Cell stress, apoptosis, and innate immune signaling","description":"The top GO terms cluster around programmed cell death (apoptosis, pyroptosis) and innate immune processes, with supporting signals from ubiquitination and stress-responsive pathways (SOS response) that modulate these outcomes. While there are also general gene-expression processes listed (splicing, ribosome biogenesis) that are broadly expressed, the prominent themes are cellular stress responses linked to cell fate decisions and innate immunity, justifying a label focused on stress-induced death and immune signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0070269","count":3},{"id":"GO:0016567","count":3},{"id":"GO:1990001","count":3}]},{"hash":"1000782277499222785","title":"Steroid and Retinoid Metabolism","description":"This cluster is driven by GO terms for biosynthesis/metabolism of steroids (testosterone, estrogen, glucocorticoids, and androgen catabolic) alongside retinoids (retinal and retinol). These together point to a cohesive theme around metabolism of lipid-derived signaling molecules and vitamin A derivatives, with additional pigment-related term (melanin biosynthesis) offering a related, pigment-development context. Some terms (like antibiotic biosynthetic process) may be noise, but the core pattern supports a focus on steroid and retinoid metabolic functions.","confidence":"Medium","size":6,"edges":10,"triangles":5,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042574","count":3},{"id":"GO:0061370","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0042438","count":3}]},{"hash":"372856534857879658","title":"Unknown","description":"This cluster mixes plant development terms (chlorophyll biosynthesis, stamen formation) with animal immune and developmental terms, plus proteostasis and adhesion, and has no interactions linking the terms. No single shared function emerges.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015995","count":2},{"id":"GO:0048455","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0006956","count":2},{"id":"GO:0006929","count":2}]},{"hash":"2269696114678138856","title":"Developmental Differentiation and Tissue Morphogenesis","description":"The terms cluster around embryonic development and tissue organization: axial mesoderm formation, myoblast differentiation, and synapse/dendrite development point to developmental differentiation; cell spreading and T cell costimulation reflect cell interactions and signaling pathways. This mix suggests a broad role in developmental processes and morphogenesis across tissues rather than a single specific pathway.","confidence":"Medium","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":5},{"id":"GO:0045663","count":5},{"id":"GO:0042698","count":5},{"id":"GO:0048320","count":5},{"id":"GO:0051965","count":5}]},{"hash":"1164960924752388862","title":"Ubiquitin-Dependent Immune Signaling","description":"These proteins cluster around ubiquitination pathways (protein ubiquitination, ubiquitin-dependent proteolysis, K63-linked ubiquitination) and immune signaling (innate immune response, TNF-mediated signaling, NF-kappaB activation) with links to adaptive immunity via V(D)J recombination. The pattern suggests a group that modulates immune responses through ubiquitin modifications and related chromatin regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0009048","count":4},{"id":"GO:0033209","count":4}]},{"hash":"938864021804095094","title":"Calcium signaling in neural, cardiac, and renal development","description":"Calcium signaling appears to be the unifying theme among these terms: regulation of ryanodine-sensitive calcium-release channels, voltage-gated calcium channel activity, and processes tied to neural plasticity (long-term potentiation, memory) as well as cardiac contraction. The inclusion of metanephric kidney/tubule development and retina layer formation suggests calcium signaling involvement across organ development as well. Taken together, the cluster seems to reflect calcium-channel\u2013mediated signaling and its roles in excitable tissues and organogenesis, rather than a single, narrow function.","confidence":"Medium","size":6,"edges":9,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035502","count":4},{"id":"GO:1900271","count":4},{"id":"GO:0060315","count":4},{"id":"GO:0072221","count":4},{"id":"GO:1901841","count":4}]},{"hash":"2179327175145647227","title":"Adaptive Immune Signaling and Ubiquitination","description":"The cluster shows clear enrichment for adaptive immune response and protein ubiquitination, with supporting hints from regulatory signaling terms like NF-kappaB activity, STAT phosphorylation, and PKC activation. Together these suggest a cohesive theme around immune signaling pathways that are modulated by ubiquitination and kinase signaling, even though a few terms reflect broader cell signaling or stress responses. This makes the immune-activation/ubiquitination axis the most representative theme for the cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0086098","count":1},{"id":"GO:0032784","count":1}]},{"hash":"917485396097574118","title":"Regulated cell migration and integrin-mediated adhesion","description":"The Top Terms include positive regulation of epithelial cell migration, lamellipodium morphogenesis, and integrin-mediated adhesion, pointing to a core theme of cell motility and adhesion signaling. Additional terms about signaling regulation (tyrosine phosphorylation, insulin signaling, glycogen biosynthesis) support broader regulatory roles but do not change the central motif.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010634","count":2},{"id":"GO:0045719","count":2},{"id":"GO:0048714","count":2},{"id":"GO:0046627","count":2},{"id":"GO:0031214","count":2}]},{"hash":"302257813129772683","title":"Neural development and axon guidance signaling","description":"The terms are dominated by neural development and axon guidance processes: axon extension regulation, neural crest migration in autonomic NS development, sympathetic ganglion development, neuromast hair cell differentiation, and HGF receptor signaling (RTK) with related VEGF/neuropilin signaling in guidance. An outlier term on complement activation appears, but the overall theme centers on neuronal differentiation and axon pathfinding, suggesting RTK- and guidance-related signaling in neural contexts.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":1},{"id":"GO:0048843","count":1},{"id":"GO:1902946","count":1},{"id":"GO:2000312","count":1},{"id":"GO:0048012","count":1}]},{"hash":"102486692063826739","title":"T cell adhesion and activation","description":"The GO terms center on immune cell interactions, with both homophilic and heterophilic cell\u2013cell adhesion, T cell costimulation, and regulation of activated T cell proliferation, plus susceptibility to cytotoxic T cell and NK cell killing and IL-4 production. These collectively point to a theme of T cell\u2013mediated immune adhesion and activation, despite a couple outlier terms (virion attachment, spermatid development) that are less representative of the cluster\u2019s core function.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":4},{"id":"GO:0060370","count":3},{"id":"GO:0043031","count":3},{"id":"GO:0042271","count":3},{"id":"GO:0046814","count":3}]},{"hash":"62087340579341505","title":"Drosophila Developmental and Stress Response","description":"The top GO terms point to embryogenesis and oogenesis-specific processes (syncytial blastoderm development and nurse cell apoptosis) alongside a cluster of stress- and signaling-related responses (hydrogen peroxide, glucose, cobalt, estradiol) and processes like protein processing and cell-cycle regulation, suggesting a breadth of development-associated and stress-response functions typical in Drosophila. This dual theme makes a label focusing on both development and cellular stress/ signaling appropriate.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":"wound healing","top_go_terms":[{"id":"GO:0043029","count":5},{"id":"GO:0042542","count":4},{"id":"GO:0001700","count":4},{"id":"GO:0016485","count":4},{"id":"GO:0048011","count":4}]},{"hash":"2090261516482131294","title":"Neuronal stress signaling and drug response","description":"The GO terms cluster around neural signaling and responsiveness to stimuli, including excitatory synaptic activity, sensory perception of sound, and responses to cocaine and ethanol, with transcriptional regulation and growth-factor\u2013related signaling providing supporting context. This suggests a theme of neuronal stress and drug-response pathways.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0090400","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0043200","count":2}]},{"hash":"646404932531480224","title":"Innate Immune Response and Coagulation with Vascular Remodeling","description":"The cluster centers on innate immune response and complement activation, with notes of cytokine production and classical coagulation, plus signals indicating endothelial proliferation and basement membrane/remodeling. This suggests a theme where innate immunity interacts with coagulation and vascular barrier remodeling during inflammation. Some terms like mechanosensation or thyroid hormone response may reflect multifunctional proteins or annotation noise, but the dominant pattern is immune/coagulation with vascular changes.","confidence":"Medium","size":6,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0016540","count":1},{"id":"GO:0097066","count":1}]},{"hash":"1549255516644301179","title":"Nucleotide metabolism and tRNA modification","description":"The GO terms show several nucleotide biosynthesis and salvage processes (uridine biosynthetic process, UMP salvage, cytosine metabolism, cytidine deamination, deoxycytidine catabolic, guanine catabolic) along with tRNA-related activities (tRNA wobble adenosine to inosine editing, mitochondrial phenylalanyl-tRNA aminoacylation). This pattern suggests a cluster centered on nucleotide metabolism and RNA-level modification/processing, particularly affecting tRNA maturation and charging, hence a coherent thematic link.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046109","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0044206","count":1},{"id":"GO:0002100","count":1},{"id":"GO:0009231","count":1}]},{"hash":"1037533187231348757","title":"Ubiquitin-Mediated Immune Regulation","description":"The top terms are dominated by ubiquitination processes (ubiquitin-dependent protein catabolic process; protein ubiquitination; K48-linked ubiquitination) and adaptive immune functions (adaptive immune response; V(D)J recombination; TNF signaling). This points to a cluster of proteins jointly involved in tagging proteins for degradation to modulate immune signaling and lymphocyte development. Some X chromosome inactivation terms appear but are less central to the main theme. Therefore the label reflects the core connection between ubiquitin pathways and immune regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0002250","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0060816","count":4},{"id":"GO:0039536","count":4}]},{"hash":"1525197529068495262","title":"Lipid Biosynthesis and Membrane Biogenesis","description":"Most of the top GO terms point to lipid metabolism and membrane-related processes (unsaturated fatty acid biosynthesis, sphingolipid metabolism, sterol regulation, myelin maintenance, and ER-targeted insertion of tail-anchored membrane proteins). This suggests a cohesive theme around building and maintaining cellular membranes and lipid components, with a few metabolism terms that are broader but still compatible with the membrane-centric view. Some terms are tissue- or organism-specific (root hair elongation, sebaceous gland differentiation), which are peripheral but can involve lipid dynamics, reinforcing the overall lipid/membrane orientation rather than a single canonical pathway.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006809","count":5},{"id":"GO:0006636","count":5},{"id":"GO:0006675","count":5},{"id":"GO:0042128","count":5},{"id":"GO:0032286","count":5}]},{"hash":"349200976654724989","title":"Nucleotide biosynthesis and phosphate metabolism","description":"The top GO terms are dominated by nucleotide-related processes (NADP+ biosynthetic process, NAD+ metabolic process, GMP biosynthetic process, purine nucleobase metabolic process) and a polyphosphate metabolic process, with phosphorylation also pointing to energy/nucleotide regulation. While a couple of terms (retina development, IL-4 response) seem incidental, the core signal supports a focus on nucleotide biosynthesis and phosphate metabolism.","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006741","count":2},{"id":"GO:0006797","count":2},{"id":"GO:0019674","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0006144","count":1}]},{"hash":"1654633889226945116","title":"Adaptive immune receptor signaling","description":"This cluster is dominated by GO terms related to B cell and T cell receptor signaling (BCR, TCR), adaptive immune response, Fc receptor signaling, and IL-2 production, indicating core adaptive immune activation and communication among lymphocytes. Additional terms for integrin signaling, LPS response, angiogenesis, and growth suggest inflammatory and vascular context accompanying immune activation, but the central theme remains adaptive immune signaling.","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0032496","count":5},{"id":"GO:0038095","count":5},{"id":"GO:0043552","count":5}]},{"hash":"2169464430562577884","title":"Proteoglycan and GAG Biosynthesis","description":"The top GO terms cluster around proteoglycan biosynthesis and metabolism (heparan sulfate, dermatan sulfate, and related glycosaminoglycans) plus polysaccharide localization, indicating a shared function in glycosaminoglycan assembly and extracellular matrix remodeling. Development terms like chondrocyte development and ureteric bud formation align with ECM roles.","confidence":"High","size":6,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":2},{"id":"GO:0030202","count":2},{"id":"GO:0015014","count":2},{"id":"GO:0033037","count":2},{"id":"GO:0015768","count":2}]},{"hash":"1575005294378328105","title":"Angiogenesis and vascular remodeling","description":"These proteins cluster around processes of blood vessel growth and remodeling. The prominent GO terms include sprouting angiogenesis, endothelial cell migration and adhesion, regulation of tissue remodeling, and modulation of TGF-beta signaling, as well as involvement in plasminogen activation/fibrinolysis and inflammatory responses. This combination points to angiogenesis and the associated remodeling of vasculature as the central theme of the cluster.","confidence":"High","size":6,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010757","count":3},{"id":"GO:0051918","count":3},{"id":"GO:0002544","count":2},{"id":"GO:0034103","count":2},{"id":"GO:0009749","count":2}]},{"hash":"202294702286581956","title":"Endothelial inflammation and ECM remodeling","description":"The cluster centers on endothelial cell behavior (proliferation, tight junction assembly), extracellular matrix organization (fibronectin fibril), and inflammatory signaling (cytokine production, acute inflammatory response, integrin signaling), consistent with vascular activation and ECM remodeling. Some terms (zymogen activation, oxidation) may reflect related proteolytic and post-translational processes but align with remodeling/inflammation themes. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0001935","count":5},{"id":"GO:1904274","count":5},{"id":"GO:1900017","count":5},{"id":"GO:0031638","count":5},{"id":"GO:0018057","count":5}]},{"hash":"736567254767590598","title":"Innate immune response proteins","description":"Based on the top GO terms, these proteins are enriched for innate immune functions (defense against Gram-positive bacteria and viruses, innate immune response). The immune-related terms dominate the cluster, indicating a cohesive innate defense role, though a few unrelated or obsolete annotations appear among the list.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0030042","count":2}]},{"hash":"1777882427561188267","title":"Triglyceride Lipolysis and Lipid Remodeling","description":"Dominant GO terms show triglyceride catabolism, mobilization, acyl-chain remodeling, and phospholipid catabolic processes, indicating a cluster focused on lipid breakdown and membrane remodeling. Some signaling-related terms suggest these lipid pathways may intersect with neuronal signaling, but the central theme remains lipid metabolism.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034638","count":2},{"id":"GO:0046338","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0006642","count":2},{"id":"GO:0036153","count":2}]},{"hash":"1819776727080006091","title":"Ribosome biogenesis and RNA modification","description":"The cluster is dominated by terms for box C/D snoRNP assembly, rRNA and snRNA pseudouridine synthesis, and LSU-rRNA maturation, alongside translation. These collectively point to RNA processing and ribosome biogenesis, with some regulatory terms (splicing, decay) likely secondary connections. ","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000492","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0031118","count":2},{"id":"GO:0048025","count":2},{"id":"GO:0046330","count":2}]},{"hash":"253092484200449983","title":"Spliceosome Assembly and RNA Processing","description":"This cluster is characterized by strong representation of RNA processing and splicing terms: mRNA cis splicing via spliceosome, spliceosomal snRNP and complex assembly, P-body assembly, tRNA processing, transcription termination, and rRNA maturation. While a few terms touch on cell cycle or stress responses, the dominant theme points to RNA maturation and spliceosome-related activities.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0030490","count":4},{"id":"GO:0070317","count":4},{"id":"GO:0033962","count":4},{"id":"GO:0000387","count":4}]},{"hash":"1019078946084051991","title":"NO-mediated vascular signaling and xenobiotic response","description":"The top GO terms point to nitric oxide biosynthesis regulation, blood pressure regulation, and smooth muscle contraction, which together suggest a vascular tone/regulatory function. Additional terms like response to cocaine and xenobiotic stimulus reinforce a broader stress- and drug-response signaling role. While protein folding and cell cycle regulation are present, they seem less central to the cluster's main theme, making NO-driven vascular signaling the best unifying label.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071318","count":2},{"id":"GO:0045429","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0042220","count":2}]},{"hash":"852271910807254693","title":"Chromatin remodeling and DNA repair","description":"Top terms point to chromatin state changes (histone acetylation/methylation, nucleosome mobilization, heterochromatin formation) and genome maintenance (double-strand break repair via homologous recombination). Developmental signals like osteoblast differentiation and TGF-beta response suggest gene regulation during differentiation linked to chromatin dynamics. A few terms (ribosomal biogenesis, GPCR signaling) appear peripheral. Overall, the cluster seems best described by chromatin remodeling and DNA repair. ","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043981","count":3},{"id":"GO:0007379","count":3},{"id":"GO:0001649","count":3},{"id":"GO:0042766","count":3},{"id":"GO:0006348","count":3}]},{"hash":"1604599093943350985","title":"Unknown","description":"The GO terms span antibiotic and SOS-related stress responses, DNA repair, ribosome biogenesis and nuclear export, and vertebrate development terms like forebrain development and neural tube closure, with no clear single function linking the five proteins. The absence of any edges or consistent pathway suggests the annotations are heterogeneous or noisy, making a confident, specific label unlikely.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0006449","count":3},{"id":"GO:0009432","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0042254","count":2}]},{"hash":"5349570314393952","title":"Unknown","description":"The top GO terms cover both immune signaling (cytokine production and T cell proliferation) and neural development (axonogenesis and motor neuron fasciculation), plus unrelated terms like pollen recognition and endothelial chemotaxis, with no edges connecting the proteins. This lack of a cohesive shared function makes a reliable cluster label unattainable. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045401","count":4},{"id":"GO:0045425","count":4},{"id":"GO:2000811","count":4},{"id":"GO:0050798","count":4},{"id":"GO:0048544","count":4}]},{"hash":"973454594934705968","title":"Peroxisomal protein import and microtubule-based transport","description":"Most terms point to peroxisome targeting and import of matrix proteins (docking, translocation, substrate release) and peroxisome movement along microtubules, with associated microtubule anchoring. A few terms about mRNA decay and protein interaction regulation are minor outliers, but the overall pattern supports a function centered on peroxisomal protein import and peroxisome transport along microtubules.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044721","count":1},{"id":"GO:0016560","count":1},{"id":"GO:0016561","count":1},{"id":"GO:0036250","count":1},{"id":"GO:0034453","count":1}]},{"hash":"236889687299145040","title":"RNA and Protein Methylation Enzymes","description":"The cluster is dominated by RNA methylation terms (guanine-N7 methylation, tRNA wobble uridine modification, rRNA and tRNA methylation, and mRNA capping) plus peptidyl-arginine methylation, pointing to methyltransferase activities as a unifying function. Cobalamin and antibiotic biosynthetic processes often involve methyltransferases, which supports a broader methylation-oriented role for these proteins. Some terms like nodulation and tellurium ion response are less central but do not override the core methylation signal.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":5},{"id":"GO:0036265","count":4},{"id":"GO:0002098","count":4},{"id":"GO:0046690","count":4},{"id":"GO:0019919","count":4}]},{"hash":"1517877514636754042","title":"RNA Polymerase I-III Transcription Machinery","description":"The GO terms span transcription by RNA polymerases I, II, and III (initiation, elongation, termination) and related processes like transcription-coupled repair and antitermination, indicating a shared core transcription machinery theme across all polymerases.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":1},{"id":"GO:0006362","count":1},{"id":"GO:0006363","count":1},{"id":"GO:0006283","count":1},{"id":"GO:0006366","count":1}]},{"hash":"874059742386753540","title":"Methyltransferases (protein and RNA)","description":"The top GO terms are dominated by various methylation processes\u2014N-terminal peptidyl-glycine methylation, peptidyl-lysine dimethylation, rRNA methylation, guanine-N7 methylation, and histone H4 methylation\u2014indicating the proteins largely function as methyltransferases modifying proteins and RNA. Additional terms for biotin and cobalamin biosynthesis and antibiotic biosynthesis likely reflect related metabolic roles or co-occurring enzymatic activities, but the unifying theme is methyltransferase activity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018013","count":4},{"id":"GO:0018027","count":3},{"id":"GO:0031167","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0070476","count":3}]},{"hash":"2134953318397789616","title":"Unknown","description":"The GO terms in this cluster are diverse (platelet secretion, morphogenesis, immune signaling, cell size regulation, and migration/degranulation), with no clear, shared biological process or pathway tying all proteins together. The lack of edges/interaction structure and the scattered functions suggest no coherent functional theme, supporting an Unknown label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070560","count":2},{"id":"GO:1903526","count":2},{"id":"GO:1904693","count":2},{"id":"GO:0098761","count":2},{"id":"GO:0060709","count":2}]},{"hash":"1019638259490661678","title":"Transcription and RNA Processing","description":"This cluster centers on nuclear gene expression, highlighted by DNA-templated transcription and mRNA processing, along with general gene expression and transcription initiation terms. While a couple of terms reference innate immune signaling (likely reflecting regulatory cross-talk or annotation overlap), the dominant theme is transcriptional activity and RNA processing, suggesting these proteins function together in transcription regulation and mRNA maturation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0035372","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1652952614976804635","title":"Neural axon guidance and axis specification","description":"These proteins cluster around neuronal development and guidance: multiple GO terms describe axon guidance for commissural, dopaminergic, and serotonergic neurons, plus involvement of planar cell polarity pathways that can guide axon trajectories. Additional terms reference left/right axis specification and sympathetic ganglion development, all pointing to a coordinated program of neural connectivity and body axis patterning. The overall theme is neural axon guidance with PCP contributions.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045880","count":2},{"id":"GO:0048105","count":2},{"id":"GO:0071679","count":2},{"id":"GO:0061549","count":2},{"id":"GO:0036514","count":2}]},{"hash":"140594387399318439","title":"GPCR Signaling and Hormone Regulation","description":"Dominant GO terms center on G protein-coupled receptor signaling (adenylate cyclase-activating and PLC-activating GPCR pathways) and hormone-related processes such as positive regulation of blood pressure and growth hormone secretion, with additional involvement of Rho signaling and cell maturation. The electron transport chain term is less reflective of the core theme, so the cluster appears to group GPCR-driven signaling tied to hormonal and vascular regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":5},{"id":"GO:0010579","count":5},{"id":"GO:0022900","count":5},{"id":"GO:0035025","count":4},{"id":"GO:0048469","count":3}]},{"hash":"1602104855898224018","title":"Tissue morphogenesis and cell migration","description":"The top GO terms include lamellipodium assembly, stress fiber assembly, and several morphogenesis terms (midbrain morphogenesis, cardiac atrium morphogenesis, anterior midgut invagination), which together point to developmental tissue shaping and cell movement. Although there is an innate immune term and a couple of obsolete terms in the list, the predominant pattern is cytoskeletal remodeling and morphogenesis during development, supporting a label around tissue formation and cell migration.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0060124","count":1},{"id":"GO:0051496","count":1},{"id":"GO:2000973","count":1}]},{"hash":"68233680621776443","title":"Autonomic regulation of cardiovascular and renal function","description":"The top GO terms point to neural control of heart rate, vasoconstriction, blood pressure, and renal sodium excretion, plus related ion transport and enteric nervous system development, suggesting a cluster centered on autonomic regulation of cardiovascular and renal physiology (with some ancillary terms like thermogenesis and chemokine signaling).","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060658","count":4},{"id":"GO:0035106","count":4},{"id":"GO:0035815","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0001996","count":4}]},{"hash":"1306986950761727626","title":"Immune Activation and Cytokine Production","description":"The top terms center on cytokine production (IL-3, GM-CSF) and immune responses (LPS response, activated T cell proliferation), suggesting a cluster tied to immune signaling and inflammatory readiness. A few terms are less cohesive (spindle checkpoint, pollen recognition, placental development), which appear as outliers, but the dominant theme is immune activation and cytokine regulation.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":4},{"id":"GO:0045401","count":4},{"id":"GO:0045425","count":4},{"id":"GO:0071222","count":4},{"id":"GO:2000811","count":4}]},{"hash":"1412910517479394242","title":"Unknown","description":"There is no common GO term signal and the cluster has minimal connectivity (one edge, no triangles, no top terms) so a coherent functional theme cannot be inferred.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"1112100970299743312","title":"Unknown","description":"The top GO terms are highly diverse (angiogenesis, phagolysosome assembly, vocalization, contact-inhibition, synapse assembly, extrinsic apoptotic signaling) with no clear shared function or pathway, and there are no edges linking the proteins, so a cohesive, confident label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090050","count":1},{"id":"GO:0001845","count":1},{"id":"GO:0071625","count":1},{"id":"GO:0060244","count":1},{"id":"GO:0051965","count":1}]},{"hash":"1488337070163527939","title":"Ubiquitin-Driven Immune Signaling (Innate and Adaptive)","description":"These proteins cluster around ubiquitin-regulated immune processes: ubiquitin-dependent proteolysis and K6-linked ubiquitination; innate defense against viruses; TNF and NF-kappaB signaling; and components tied to spleen development and V(D)J recombination, implying roles in both innate and adaptive immunity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0048536","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0033209","count":3}]},{"hash":"336394790412359246","title":"Chromatin Silencing and Transcription Regulation","description":"The terms cluster around chromatin organization and gene expression control, with multiple entries for heterochromatin formation, chromatin silencing, and DNA-templated transcription, suggesting a shared role in regulating chromatin state and transcription.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0071922","count":5},{"id":"GO:0045128","count":5},{"id":"GO:0014894","count":5},{"id":"GO:0031939","count":5}]},{"hash":"1549687767837422720","title":"Unknown","description":"The GO terms are highly heterogeneous, ranging from development (gastrulation) to various metabolic and catabolic processes (ferrichrome biosynthesis, 2-oxoglutarate metabolism, camphor and halogen metabolism) and oxidative responses, with several obsolete terms. There is no clear, single biological theme that ties the proteins together, and there are no reported interactions (edges) to support a cohesive function. This suggests annotation noise or multifunctional proteins rather than a distinct pathway cluster.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007369","count":2},{"id":"GO:0031169","count":2},{"id":"GO:0019646","count":2},{"id":"GO:0071455","count":2},{"id":"GO:0006214","count":2}]},{"hash":"1661946836223296888","title":"Immune activation and cytokine production","description":"This cluster is driven by immune-related GO terms: positive regulation of IL-3 and GM-CSF production, activated T cell proliferation, and cellular response to lipopolysaccharide, indicating a theme of cytokine signaling and T cell\u2013mediated activation. Some terms appear as outliers (pollen recognition, response to cocaine, spindle assembly regulation), but the dominant pattern suggests an immune activation/cytokine-production function.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":5},{"id":"GO:0045401","count":5},{"id":"GO:0045425","count":5},{"id":"GO:0071222","count":5},{"id":"GO:2000811","count":5}]},{"hash":"433111423016380191","title":"Calcium-Driven neural, muscle, and vascular development","description":"The cluster prominently features calcium signaling and its downstream pathways (detection of calcium ion; calcineurin-NFAT signaling cascade) and ties together neural-related terms (Schwann cell development, substantia nigra development, cocaine response) with muscle and vascular development (skeletal muscle fiber development, branching in blood vessel morphogenesis) and connective tissue remodeling, suggesting calcium-dependent regulation across these tissues.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1905205","count":5},{"id":"GO:0033173","count":5},{"id":"GO:0014044","count":5},{"id":"GO:0005513","count":5},{"id":"GO:0042220","count":5}]},{"hash":"2286276672533451068","title":"DNA Damage Response and Ubiquitination","description":"These proteins cluster around DNA damage signaling and repair (mitotic G1 checkpoint and homologous recombination) and show enrichment for multiple ubiquitin linkage types (K48, K27, K11) with SUMO regulation, suggesting a cohesive role in ubiquitin/SUMO-regulated DNA damage response and protein turnover. Peripheral terms such as hyperoxia response and Fc-epsilon receptor signaling are present but less central to the main function.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031571","count":5},{"id":"GO:1903755","count":5},{"id":"GO:0070936","count":5},{"id":"GO:0031939","count":5},{"id":"GO:0044314","count":5}]},{"hash":"2033372120534714061","title":"DNA Damage Response and Ubiquitination","description":"The cluster shows proteins associated with DNA damage sensing/repair (mitotic G1 checkpoint signaling, homologous recombination repair) and prominent ubiquitination signals (K48-, K27-, K11-linked ubiquitination) with SUMO regulation hints, suggesting a coordinated role in genome maintenance through ubiquitin/SUMO modification pathways. Some terms appear as outliers (Fc-epsilon receptor signaling, retinal apoptotic processes), but the core theme centers on preserving genome integrity via post-translational modification and DNA damage response.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031571","count":5},{"id":"GO:1903755","count":5},{"id":"GO:0070936","count":5},{"id":"GO:0031939","count":5},{"id":"GO:0044314","count":5}]},{"hash":"1955454655095649797","title":"DNA Damage Response via Ubiquitination and SUMOylation","description":"The cluster is dominated by ubiquitin linkages (K48, K27, K11) and SUMOylation activity, pointing to post-translational modification-based signaling. Coupled with mitotic G1 DNA damage checkpoint signaling and homologous recombination repair, the proteins appear to function together in DNA damage detection and repair through ubiquitin/SUMO pathways. Some terms are unrelated or obsolete, but the core theme centers on DDR signaling and protein modification.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031571","count":5},{"id":"GO:1903755","count":5},{"id":"GO:0070936","count":5},{"id":"GO:0031939","count":5},{"id":"GO:0044314","count":5}]},{"hash":"423993181298448505","title":"Innate Immunity and Coagulation","description":"Proteins cluster around innate immune activation (complement activation, lectin pathway; IL-1\u2013related responses) and hemostasis (blood coagulation, platelet aggregation and its regulation). Additional terms reflect stress and repair processes (UV-B response, axon regeneration) but the dominant theme is inflammation and clotting, suggesting this cluster represents immune/coagulation-related functions despite sparse direct connectivity.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0072378","count":2},{"id":"GO:0071493","count":2}]},{"hash":"1302519430428105403","title":"Unknown","description":"The top GO terms span diverse biological areas, including development (axial mesoderm formation, myoblast differentiation, ovulation cycle, dendrite/synapse development), immune signaling (T cell costimulation, lymphangiogenesis), and other processes (chitin catabolic process, endosome transport, cell spreading). There isn\u2019t a single cohesive function linking all terms, so the cluster appears heterogeneous or lacks a common theme.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":5},{"id":"GO:0045663","count":5},{"id":"GO:0042698","count":5},{"id":"GO:0048320","count":5},{"id":"GO:0051965","count":5}]},{"hash":"1185546888079779110","title":"Coagulation and collagen fibril organization","description":"The cluster\u2019s top GO terms center on collagen fibril organization and coagulation-related processes (blood coagulation/fibrin clot formation and platelet aggregation), with one term for negative regulation of platelet aggregation suggesting a balance in hemostasis. Additionally, there are inflammatory/immune signals (complement activation lectin pathway, cellular response to interleukin-1) and cell-adhesion/apoptotic-cell recognition terms that fit a wound-healing context where extracellular matrix remodeling, coagulation, and immune responses are coordinated. This points to a cohesive theme around extracellular matrix organization linked to hemostasis and inflammatory signaling in tissue repair.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0001867","count":1},{"id":"GO:0071347","count":1},{"id":"GO:0072378","count":1},{"id":"GO:0071493","count":1}]},{"hash":"635556382336218852","title":"Epigenetic Regulation of Gene Expression","description":"The cluster shows terms tied to chromatin state and transcription, such as DNA-templated transcription, nucleosome assembly, and histone methylation, which are hallmarks of epigenetic control of gene expression. Some developmental terms (gliogenesis, placenta morphogenesis) reflect regulatory roles in development, aligning with a broader theme of gene expression modulation rather than a single pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060669","count":1},{"id":"GO:0014834","count":1},{"id":"GO:0034772","count":1},{"id":"GO:0080182","count":1},{"id":"GO:0006351","count":1}]},{"hash":"371913480548097093","title":"Mitochondrial respiration and ROS response","description":"This cluster centers on mitochondrial energy production and oxidative stress handling, with terms for the electron transport chain, Complex I assembly, and regulation of cytochrome c release, plus responses to hydrogen peroxide and iron homeostasis. While a couple terms touch on broader roles like development and proliferation, the dominant signals point to mitochondria-driven respiration and ROS management.","confidence":"High","size":5,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":1},{"id":"GO:0019933","count":1},{"id":"GO:0032981","count":1},{"id":"GO:0051591","count":1},{"id":"GO:0048146","count":1}]},{"hash":"1132654160991161907","title":"Unknown","description":"The GO terms span diverse processes\u2014from chitin catabolism and ovulation to axial mesoderm formation, synapse/dendrite development, immune costimulation, endosome transport, and cell spreading\u2014indicating no single cohesive function ties the cluster together.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":3},{"id":"GO:0045663","count":3},{"id":"GO:0042698","count":3},{"id":"GO:0048320","count":3},{"id":"GO:0051965","count":3}]},{"hash":"1617290089336747291","title":"Nuclear DNA replication, repair, and mitosis","description":"This cluster centers on nuclear genome maintenance and cell division, with GO terms for homologous recombination repair, Okazaki fragment processing in mitotic replication, and mitotic spindle assembly, plus related transcription and ribosome biogenesis activities that support cell growth. While there are a few signaling-related terms, the dominant theme is DNA replication/repair and mitotic machinery, making this a coherent, specific cluster label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000724","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007200","count":2},{"id":"GO:0061087","count":2}]},{"hash":"1598097381121181614","title":"Unknown","description":"The GO terms include proteasome assembly and ubiquitin-dependent protein catabolic process (protein turnover), chlorophyll biosynthesis (chloroplast metabolism), stamen formation (plant development), and DNA integration, with no clear shared function linking all terms. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":1},{"id":"GO:0015995","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0048455","count":1},{"id":"GO:0015074","count":1}]},{"hash":"909856846791664140","title":"Nutrient transporters (sugars and vitamins)","description":"Top GO terms indicate membrane transport of myo-inositol, glucose, biotin, pantothenate, and sodium, pointing to a group of transport proteins that move nutrients and cofactors across membranes. A few mitochondrial assembly terms appear but are minor; the dominant signal is transmembrane nutrient transport.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015878","count":2},{"id":"GO:0015887","count":2}]},{"hash":"1808137791569308834","title":"Proteostasis and Protein Quality Control","description":"These proteins appear tied to maintaining protein homeostasis: ubiquitin-proteasome\u2013mediated degradation, protein folding, processing, and quality control in the cytoplasm and ER, as well as trafficking to the Golgi and regulation of secretion. The GO terms strongly point to a proteostasis/secretory quality-control theme for this cluster.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0071629","count":1},{"id":"GO:0006457","count":1},{"id":"GO:1902235","count":1}]},{"hash":"726211468957379835","title":"Protein quality-control and stress regulation","description":"This cluster centers on mechanisms that control protein homeostasis and cellular stress responses, including deubiquitination and negative regulation of proteasomal degradation, aggrephagy, and modulation of ER stress-related apoptosis. It also includes broader stress responses (cadmium, insecticide) and vesicle/endosomal regulation, suggesting a cohesive theme around maintaining protein quality and cell survival under stress. Some terms (e.g., nucleotide-excision repair) are less directly aligned, but overall the proteostasis and stress-regulation signal is clear. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070911","count":5},{"id":"GO:0016579","count":5},{"id":"GO:1905366","count":5},{"id":"GO:1901340","count":5},{"id":"GO:0017085","count":5}]},{"hash":"1873075675683754189","title":"Innate Immune TNF\u2013NF-\u03baB Signaling","description":"This cluster is enriched for innate immune response and TNF-mediated signaling, including NF-\u03baB activation and JNK pathway regulation, with associated IL-17 signaling and ubiquitin-dependent proteolysis. These terms together point to inflammatory immune signaling and protein turnover, though one term about X-chromosome dosage compensation appears unrelated and may be an annotation artifact.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0009048","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0045087","count":2}]},{"hash":"2015269101330312237","title":"Tooth and bone mineralization","description":"The GO terms are dominated by odontogenesis and mineralization processes (tooth eruption, dentinogenesis, enamel mineralization, osteoblast differentiation, bone mineralization, odontoblast differentiation), with related bone remodeling signals (osteoclast maturation, FGFR signaling regulation). This points to a cohesive theme of dental and skeletal mineralization and development.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040036","count":1},{"id":"GO:0036179","count":1},{"id":"GO:0044691","count":1},{"id":"GO:0045669","count":1},{"id":"GO:0097187","count":1}]},{"hash":"21993927958812878","title":"Ubiquitin-dependent protein turnover","description":"The cluster is dominated by ubiquitination-related GO terms (K48-linked ubiquitination; ubiquitin-dependent protein catabolic process; actin ubiquitination), pointing to a core role in tagging proteins for degradation. While other terms touch on DNA replication, microtubule localization, and immune-related processes, they may reflect broader roles tied to protein turnover affecting signaling and trafficking.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0060816","count":2},{"id":"GO:0035372","count":2},{"id":"GO:0070936","count":2},{"id":"GO:0042787","count":2}]},{"hash":"516678773507498749","title":"Unknown","description":"The top GO terms point to immune activation (cytokine production, T cell proliferation, LPS response) but are mixed with diverse, unrelated processes (pollen recognition, cocaine response, spindle checkpoint regulation, placental development) and there are no observed edges linking the proteins. This makes a single cohesive label unlikely, so Unknown is most appropriate.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":5},{"id":"GO:0045401","count":5},{"id":"GO:0045425","count":5},{"id":"GO:0071222","count":5},{"id":"GO:2000811","count":5}]},{"hash":"814449369270564538","title":"Ubiquitin-mediated signaling and degradation","description":"The top GO terms cluster around ubiquitin-dependent protein catabolism and various ubiquitin linkages (K6, K63, K48), including autoubiquitination and aggresome formation, with connections to NF-kappaB and TNF signaling and necroptosis regulation, suggesting a cohesive module of ubiquitin-driven proteostasis and inflammatory signaling.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0036205","count":3}]},{"hash":"867258623989473523","title":"Wnt/Planar polarity signaling in neural development","description":"This cluster centers on terms related to planar cell polarity (PCP) and Wnt signaling, including epithelial polarity, convergent extension in neural plate elongation, and neural tube-related PCP processes, suggesting a cohesive role in Wnt/PCP signaling guiding neural development. Some terms like grooming behavior and various secretion processes appear as peripheral or broader functional associations, but the core theme is PCP/Wnt-driven neural development.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000821","count":1},{"id":"GO:0045198","count":1},{"id":"GO:0032782","count":1},{"id":"GO:0014047","count":1},{"id":"GO:0019933","count":1}]},{"hash":"1716813029124854329","title":"Neural exocytosis and cytokine regulation","description":"The top GO terms point to control of cytokine production, vesicle trafficking and calcium-dependent exocytosis, along with signaling pathways like calcineurin-NFAT and astrocyte activation. This suggests a cohesive theme of vesicle-mediated signaling and immune-modulatory communication in neural cells, particularly involving astrocytes and neuronal signaling processes. While a few terms are peripheral, the core pattern centers on exocytosis-driven signaling and cytokine regulation in the nervous system.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050715","count":4},{"id":"GO:0015031","count":4},{"id":"GO:0045806","count":4},{"id":"GO:0045956","count":4},{"id":"GO:1905205","count":1}]},{"hash":"59272463359187284","title":"Coagulation, fibrinolysis, and angiogenesis regulators","description":"The prominent terms\u2014plasminogen activation, fibrinolysis, complement activation via lectin pathway, angiogenesis, and vasoconstriction\u2014point to a shared role in coagulation and vascular remodeling, with supporting signals via receptor tyrosine kinases and cell adhesion modulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0010812","count":2},{"id":"GO:0007171","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0045766","count":2}]},{"hash":"49752805203894376","title":"Immune activation and inflammatory signaling","description":"The top GO terms predominantly relate to immune responses and inflammation (e.g., IL-3 and GM-CSF production, T cell proliferation, and LPS response), indicating a cohesive immune-activation module; some terms are broader stress or recognition responses, but the core theme is immune signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":5},{"id":"GO:0045401","count":5},{"id":"GO:0045425","count":5},{"id":"GO:0071222","count":5},{"id":"GO:2000811","count":5}]},{"hash":"744663637100122696","title":"LPS-Responsive NF-kB Transcriptional Regulation","description":"The cluster\u2019s prominent GO terms are centered on immune/inflammatory signaling (cellular response to lipopolysaccharide and negative regulation of canonical NF-kappaB signaling) and general transcription (DNA-templated transcription). Although a few terms touch on development in specific tissues, the strongest signals point to inflammation-driven transcriptional control, making this a cohesive label that captures the core function of the group.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0035726","count":2},{"id":"GO:0060749","count":2},{"id":"GO:0071638","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1941266564461996239","title":"Neural development and cell adhesion signaling","description":"Most terms point to nervous system development (GO:0007399), myelination (GO:0042552), and signaling pathways involved in neural patterning and guidance (ROBO signaling GO:0035385; SHH pathway GO:0007224). In addition, there are multiple adhesion-related terms (homophilic and heterophilic cell-cell adhesion). Together, these suggest proteins involved in neural development and neuron\u2013cell adhesion processes, including axon guidance and myelination. The cluster has no observed edges, so it appears to be a set of co-annotated components rather than a tightly interacting complex, but the GO signal supports this high-level functional label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043031","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0007224","count":3}]},{"hash":"1786823168512260378","title":"Cardiac muscle development and heart contraction","description":"Most terms cluster around cardiac/muscle development and heart function (cardiac muscle tissue development, cardiac muscle cell development, muscle organ development, heart contraction), with supporting vascular smooth muscle development. A few terms seem tangential (plant strigolactone biosynthesis, epoxygenase P450 pathway), but the dominant theme is cardiac muscle formation and heart activity.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048738","count":1},{"id":"GO:0048747","count":1},{"id":"GO:0055013","count":1},{"id":"GO:0060047","count":1},{"id":"GO:0097084","count":1}]},{"hash":"827933438652745695","title":"Innate Immune Response and Hemostasis","description":"The top GO terms point to immune-related and coagulation processes, including complement activation (lectin pathway), cellular responses to IL-1, blood coagulation and fibrin clot formation, platelet aggregation and its regulation, and recognition of apoptotic cells. These functions collectively indicate a cluster tied to innate immune signaling and hemostasis/platelet activity, with other signaling terms present that support broader cellular activation context.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0071347","count":3},{"id":"GO:0072378","count":3},{"id":"GO:0071493","count":3},{"id":"GO:0014814","count":3}]},{"hash":"669497167706900160","title":"Unknown","description":"The GO terms show a highly diverse mix including ischemia response, virion assembly, telomere localization, antibody class switching, immune response modulation, RNA processing in Cajal bodies, and chaperone-related protein folding. There isn't a single unifying function or pathway tying these terms together, suggesting the cluster lacks a coherent biological theme.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002931","count":3},{"id":"GO:0019068","count":2},{"id":"GO:1904851","count":2},{"id":"GO:0048291","count":2},{"id":"GO:0002842","count":2}]},{"hash":"2104452484991364229","title":"Unknown","description":"The top GO terms span virion assembly, telomere maintenance/localization, immune responses (isotype switching and T cell\u2013mediated tumor response), nuclear RNA processing (scaRNA localization to Cajal bodies), and chaperone-related protein folding, with additional broad \u201cresponse\u201d terms. There is no coherent, single biological theme that ties all four proteins together, suggesting the cluster is functionally heterogeneous rather than representing a distinct, cohesive pathway.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019068","count":4},{"id":"GO:1904851","count":4},{"id":"GO:0048291","count":4},{"id":"GO:0002842","count":4},{"id":"GO:0090666","count":4}]},{"hash":"967242833994715239","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"Top GO terms emphasize ubiquitin-mediated protein catabolism and various ubiquitin linkages (K11, K48, K63, K6), including autoubiquitination, suggesting a core role in protein turnover. Additional terms point to regulation of canonical NF-\u03baB signaling and TNF-mediated pathways, with related processes like histone catabolism\u2014consistent with chromatin-associated ubiquitination. Together, these terms define a cluster of proteins involved in ubiquitin tagging for degradation and signaling control of inflammatory pathways.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0070979","count":2},{"id":"GO:0070936","count":2},{"id":"GO:0085020","count":2},{"id":"GO:0043123","count":2}]},{"hash":"485334858106963858","title":"Membrane Transport and Ion Homeostasis","description":"The cluster shows a consistent emphasis on transmembrane transport across a variety of substrates (bicarbonate, chloride, sulfate, oxalate, fructose, aspartate) and processes affecting membrane potential and intracellular pH, suggesting these proteins function in transporters or regulators of ionic and pH balance.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042391","count":1},{"id":"GO:0001696","count":1},{"id":"GO:0019532","count":1},{"id":"GO:0051454","count":1},{"id":"GO:0089712","count":1}]},{"hash":"1063799231691448697","title":"Viral entry, assembly, and host response","description":"The top GO terms cluster around viral life-cycle steps and host interactions: virion assembly, uncoating, fusion with the host membrane, and entry into host cells, plus host-driven activation of viral genome replication and downstream immune responses such as leukocyte migration. Protein folding/isomerization terms may reflect chaperone involvement in viral protein maturation, while some terms (e.g., the obsolete regulation term) are ancillary. Overall, a cohesive theme is viral infection processes and host response.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"protein folding","top_go_terms":[{"id":"GO:0006457","count":3},{"id":"GO:0019068","count":3},{"id":"GO:0030260","count":3},{"id":"GO:0000413","count":3},{"id":"GO:0050900","count":3}]},{"hash":"503409809571589272","title":"DNA replication, chromatin organization, and transcription regulation","description":"GO terms point to nuclear DNA processes: replication elongation, DNA strand changes, chromatin organization, mitotic chromosome condensation, and transcription elongation and regulation by RNA polymerase II, including circadian regulation of gene expression.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006271","count":1},{"id":"GO:0006265","count":1},{"id":"GO:0032922","count":1},{"id":"GO:0007076","count":1},{"id":"GO:0006357","count":1}]},{"hash":"1038809479598240207","title":"Flavonoid glycoside biosynthesis","description":"The top GO terms are dominated by biosynthesis of flavonoid glycosides (kaempferol, cyanidin, quercetin glucosides, etc.), suggesting a plant secondary metabolism focus on flavonoid glycosides. A few other terms (e.g., estrogen/catabolic processes, axon localization) are less central and may reflect background annotations, but the flavonoid-related terms best define the cluster.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006711","count":3},{"id":"GO:0033330","count":3},{"id":"GO:0009718","count":3},{"id":"GO:0070980","count":3},{"id":"GO:0002175","count":3}]},{"hash":"935646676988224769","title":"Unknown","description":"The top terms span very disparate processes\u2014from lipopolysaccharide biosynthesis to calcium transport, muscle relaxation, and various signaling regulatory pathways\u2014without a unifying function. This suggests either diverse protein roles or heterogeneous annotations, making a cohesive label unreliable.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:0016311","count":2},{"id":"GO:0019373","count":1},{"id":"GO:0010751","count":1},{"id":"GO:1903515","count":1}]},{"hash":"524508716002090319","title":"RNA and protein methylation","description":"Top GO terms are dominated by methylation-related processes, including rRNA (guanine-N7)-methylation, histone H4-R3 methylation, peptidyl-lysine dimethylation, N-terminal peptidyl-alanine trimethylation, and tRNA modification, suggesting a cluster of methyltransferase activities on RNA and proteins. While some metabolic terms appear, the strongest signal points to methylation-modifying enzymes; thus the label captures the core shared function. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001887","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0070476","count":2},{"id":"GO:0043985","count":2},{"id":"GO:0051555","count":2}]},{"hash":"2258911517451634028","title":"mRNA processing and translation initiation regulation","description":"The cluster shows strong representation of mRNA processing and maturation steps (splicing, splice site recognition, export, stability under stress, and mRNA modification) together with translation initiation components (preinitiation complex formation and initiation regulation). This suggests a functional module that links RNA processing with control of translation, hence a label capturing both aspects.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0016556","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0010610","count":4}]},{"hash":"894614657761099977","title":"Developmental Transcriptional Regulation","description":"The top GO terms show a clear emphasis on negative regulation of transcription by RNA polymerase II and several developmental processes (eye morphogenesis, embryonic skeletal morphogenesis, gastrulation), suggesting a theme of transcriptional control during development. Other terms (signaling, ubiquitin-dependent proteolysis) are present but less central, and the lack of edges indicates a loosely connected cluster; overall, this label captures the strongest shared function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0048593","count":2},{"id":"GO:0048103","count":2},{"id":"GO:0039536","count":2},{"id":"GO:0070301","count":2}]},{"hash":"37489497036825796","title":"Ras signaling regulation","description":"The top GO terms are centered on small GTPase signaling and specifically negative regulation of Ras signaling, suggesting the proteins in this cluster are involved in modulating Ras pathway activity. While there are additional terms related to osmotic stress and ion transport, these appear ancillary to the dominant Ras-regulation theme, which is the most coherent common function among the terms provided.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0006970","count":2},{"id":"GO:2001199","count":1}]},{"hash":"766988324240041089","title":"Embryonic organ morphogenesis","description":"The top GO terms cluster around embryonic development and organ morphogenesis, including ureteric bud branching, endocrine pancreas development, neural crest cell migration, digestive tract morphogenesis, and sprouting angiogenesis. This suggests a shared theme of embryonic tissue formation and organogenesis, rather than a single tight pathway, justifying a label centered on development and morphogenesis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090190","count":3},{"id":"GO:0031018","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0048557","count":3}]},{"hash":"630052528052949465","title":"Regulated dense-core vesicle exocytosis","description":"The cluster\u2019s GO terms center on secretory vesicle fusion and granule exocytosis, notably positive regulation of dense core granule exocytosis and insulin secretion in response to glucose. These strongly point to a role in regulated secretion (dense-core granules) rather than generic transport, with related but broader terms (IP3 biosynthesis, intracellular transport) providing contextual support. Confidence in this theme is High. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016540","count":1},{"id":"GO:0035773","count":1},{"id":"GO:1905415","count":1},{"id":"GO:0031340","count":1},{"id":"GO:1904468","count":1}]},{"hash":"1473994501329015137","title":"Small-molecule metabolism: amino acids and vitamins","description":"The proteins in this cluster appear linked to a variety of small-molecule metabolic processes, including catabolism of pyruvate, oxalate, taurine, glyoxylate, and butanediol, as well as biosynthesis of thiamine, phylloquinone, and menaquinone, and amino acid biosynthesis (valine, isoleucine). This suggests a broad metabolic role focused on carbon compound processing and cofactor production, rather than a single, cohesive pathway.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034077","count":2},{"id":"GO:0090180","count":2},{"id":"GO:0033611","count":2},{"id":"GO:0019529","count":2},{"id":"GO:0009436","count":2}]},{"hash":"1688158306685417418","title":"Embryonic organ morphogenesis","description":"This cluster\u2019s strongest signals are developmental and morphogenetic processes across multiple organs (forelimb, inner ear, retina, pituitary) and pattern formation, suggesting a shared theme of embryonic organ morphogenesis. The other terms (nutrient response, GABA catabolism, hypoxia response) are more peripheral, reflecting co-regulation during development.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035115","count":4},{"id":"GO:0042472","count":4},{"id":"GO:0042574","count":4},{"id":"GO:0009954","count":4},{"id":"GO:0007584","count":4}]},{"hash":"1851117958574552793","title":"Xenobiotic response and fatty acid metabolism","description":"The top GO terms point to fatty acid biosynthesis (lipid metabolism) and responses to xenobiotic stimuli such as lipopolysaccharide and nitrosative stress, suggesting the cluster centers on metabolism coupled to detox/stress responses. Some terms like respiratory system process or blood pressure regulation seem noisy or cross-species, but the core pattern links metabolism with xenobiotic/stress response.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0042493","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0003016","count":2}]},{"hash":"1913089230770178821","title":"Mitotic regulation and antiviral response","description":"This cluster centers on cell division and mitotic control, with multiple terms tied to regulation of the mitotic cell cycle, plus ubiquitin-mediated protein modification (K11-linked ubiquitination) suggesting tight cell-cycle control and protein turnover. Additional terms point to oxidative stress response and antiviral defense, indicating the proteins may participate in mitotic processes that intersect with stress signaling and immune responses. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0070301","count":2},{"id":"GO:0045070","count":2},{"id":"GO:0055059","count":2},{"id":"GO:0000413","count":2}]},{"hash":"1150067567959835501","title":"Mitotic spindle assembly and cytokinesis","description":"The GO terms show strong enrichment for mitosis-related processes: cell division, cell cycle, cytoplasmic microtubule organization, mitotic spindle pole body duplication, spindle midzone assembly, microtubule nucleation, and mitotic cytokinesis/division site positioning, indicating a cluster of proteins involved in spindle function and cell division. The single IL-4\u2013related term appears incidental rather than central to the cluster\u2019s theme.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0031122","count":3},{"id":"GO:1903087","count":3},{"id":"GO:0051256","count":3},{"id":"GO:0071353","count":3}]},{"hash":"1602910266035575542","title":"DNA Damage Response & Ubiquitin Signaling","description":"Core functions point to DNA damage response and ubiquitin signaling. The prominent terms include mitotic G1 DNA damage checkpoint signaling, homologous recombination repair, and various ubiquitin linkages (K48, K27, K11) as well as SUMO regulation, suggesting regulation of DNA damage response by ubiquitination/SUMOylation. Some outliers exist but do not define the cluster. Label reflects these dominant themes.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031571","count":4},{"id":"GO:1903755","count":4},{"id":"GO:0070936","count":4},{"id":"GO:0031939","count":4},{"id":"GO:0044314","count":4}]},{"hash":"1319864224754006568","title":"Unknown","description":"The GO terms are scattered across sporulation, nutrient response, multiple biosynthetic/catabolic pathways, circadian rhythm, and hypoxia, with no clear shared function or interaction pattern. Given the lack of a coherent theme or connectivity, a specific, representative label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0030435","count":1},{"id":"GO:0007584","count":1},{"id":"GO:0008615","count":1},{"id":"GO:0071268","count":1}]},{"hash":"2108729848083433818","title":"Inflammation and coagulation regulation","description":"The GO terms prominently feature immune/inflammatory signaling (complement activation via lectin pathway; cellular response to interleukin-1) and hemostasis processes (blood coagulation, fibrin clot formation, platelet aggregation and its regulation, recognition of apoptotic cells). Together these point to a thrombo-inflammatory functional theme, linking innate immunity with coagulation; a couple of terms reflect broader stress responses (UV-B, osteoblast regulation), but the core signal centers on inflammation-coagulation interplay.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033689","count":4},{"id":"GO:0001867","count":3},{"id":"GO:0071347","count":3},{"id":"GO:0072378","count":3},{"id":"GO:0071493","count":3}]},{"hash":"1990263897220365333","title":"Unknown","description":"The GO terms span both metabolism (glycogen biosynthesis regulation, ATP transport) and a wide array of developmental and signaling processes across multiple tissues (glial/neuronal differentiation, innervation, chondrocyte and biomineral tissue development, coagulation, insulin signaling). The lack of a single coherent function or pathway linking these terms suggests no clear common theme for this cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045719","count":2},{"id":"GO:0015867","count":2},{"id":"GO:0048714","count":2},{"id":"GO:0046627","count":2},{"id":"GO:0035860","count":2}]},{"hash":"896289279913313387","title":"Innate Immune Defense and Complement Activation","description":"The top GO terms are strongly immunological: innate immune response, defense against Gram-positive bacteria, phagolysosome assembly, and especially complement activation via the classical pathway, pointing to innate immunity and complement-mediated defense as the core theme. A few terms related to cell division or fertilization appear but are less represented and likely incidental. Thus, the cluster is best characterized by innate immune defense and complement activation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0001845","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0035264","count":2}]},{"hash":"1569623514304022355","title":"Embryonic development and lineage differentiation","description":"The GO terms point to differentiation and morphogenesis across multiple lineages: gamma-delta T cell differentiation, endothelial and myoblast differentiation, cardiac neural crest\u2013related outflow tract development, and regulation of somitogenesis. While there are immune and neural contexts, the common thread is developmental lineage specification and tissue morphogenesis, suggesting these proteins participate in broad developmental differentiation programs rather than a single specialized pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042492","count":3},{"id":"GO:0030194","count":3},{"id":"GO:0061309","count":3},{"id":"GO:0071672","count":3},{"id":"GO:0051968","count":3}]},{"hash":"1285733777949219474","title":"Apoptosis and pyroptosis in innate immunity","description":"These terms converge on programmed cell death (apoptosis and pyroptosis) and innate immune signaling, reinforced by ubiquitination and LPS response, suggesting a coherent theme of inflammatory cell death and immune activation rather than a structural complex.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0070269","count":3},{"id":"GO:0016567","count":3},{"id":"GO:1990001","count":3}]},{"hash":"1641131764414500901","title":"Programmed cell death and innate immunity","description":"Based on the top GO terms, the proteins are enriched for programmed cell death (apoptotic process, pyroptotic inflammatory response) and innate immune signaling, with ubiquitination suggesting regulation of these pathways. While additional terms (mitotic spindle assembly, dendrite regeneration, endodermal differentiation, chloride transport) appear more peripheral, the core pattern points to involvement in inflammatory cell death and immune regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:1990001","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0070269","count":2}]},{"hash":"1978833228208733715","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006593","count":1},{"id":"GO:0070781","count":1},{"id":"GO:0007494","count":1},{"id":"GO:0044205","count":1},{"id":"GO:0033390","count":1}]},{"hash":"271736864409194796","title":"Unknown","description":"The top terms show a mix of cardiac muscle signaling, membrane trafficking, lipid metabolism, and even plant- or immune-related processes, with no single coherent function tying all proteins together. This scattered functional signature makes it unclear what explicit common role defines the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900827","count":1},{"id":"GO:0046475","count":1},{"id":"GO:2000031","count":1},{"id":"GO:0090501","count":1},{"id":"GO:0044707","count":1}]},{"hash":"2163935002188047774","title":"Nuclear transport and mRNA export","description":"Most of the top GO terms point to trafficking between the nucleus and cytoplasm: nuclear pore localization, protein import into the nucleus, and mRNA export from the nucleus, plus general protein transmembrane transport. Some terms (neurogenesis, light absorption) appear as outliers, but do not negate the core theme of intracellular/nuclear transport. Therefore the label reflects the dominant function of the cluster.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":2},{"id":"GO:0045571","count":1},{"id":"GO:0016037","count":1},{"id":"GO:1904046","count":1},{"id":"GO:0018298","count":1}]},{"hash":"89470785460123855","title":"Unknown","description":"The four proteins show a highly diverse set of GO terms, including nucleotide-excision repair (global and preincision complex stabilization, DNA damage recognition), ubiquitin-dependent proteolysis (K48-linked ubiquitination), dosage compensation (X chromosome inactivation), and immune signaling (RIG-I regulation, TNF signaling) as well as V(D)J recombination. There is no clear, cohesive functional theme tying these annotations together, and there are no network edges to support a unified pathway. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070911","count":1},{"id":"GO:0060816","count":1},{"id":"GO:0039536","count":1},{"id":"GO:0070936","count":1},{"id":"GO:0006293","count":1}]},{"hash":"150196053545874163","title":"Neuronal Development and Axon Guidance","description":"This cluster is dominated by GO terms tied to nervous system development, neurogenesis, axon guidance, synapse assembly, ROBO signaling, and Hedgehog pathway involvement in development. While a couple terms relate to other processes (e.g., myoblast differentiation), the overall signal supports neural differentiation and connectivity, so a label emphasizing neural development and axon guidance is appropriate.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045663","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0035385","count":2},{"id":"GO:0007422","count":2},{"id":"GO:0022008","count":2}]},{"hash":"438964445710443676","title":"DNA Damage Response and Cell Cycle Checkpoints","description":"The proteins cluster around DNA damage sensing/repair and mitotic G1 checkpoint signaling, with accompanying roles in negative regulation of cell proliferation and ubiquitin-related processes, suggesting a coherent DNA damage response and cell cycle control module. Additional terms related to general stress responses (cadmium, ethanol) and innate immunity appear ancillary to this core theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051436","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0031571","count":3},{"id":"GO:0035372","count":2}]},{"hash":"1172128226947828258","title":"mRNA processing and translation initiation regulation","description":"This cluster clusters proteins involved in splicing regulation, mRNA export and modification, mRNA stability under stress, and the initiation/formation of the translation preinitiation complex, pointing to a cohesive role in mRNA maturation and control of translation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":1},{"id":"GO:0048026","count":1},{"id":"GO:0016556","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0010610","count":1}]},{"hash":"1181293464434426299","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006620","count":2},{"id":"GO:0051083","count":2},{"id":"GO:0019068","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0039702","count":1}]},{"hash":"1924702487134659698","title":"Unknown","description":"The GO terms span photosynthesis and energy-related plant processes, nitrate assimilation, and aromatic hydrocarbon catabolism, with no evident shared function or interaction among the four proteins. Because there is no cohesive theme linking the terms and no edges connecting members, a meaningful specific label cannot be derived.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046381","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0042203","count":1},{"id":"GO:0010196","count":1},{"id":"GO:0046232","count":1}]},{"hash":"535826084042583764","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms related to nervous system development and axon guidance\u2014axon extension and fasciculation, synapse assembly, mechanoreceptor differentiation, and Roundabout (ROBO) signaling involved in axon guidance and neuronal migration. While an innate immune term appears, the strongest signal ties to neural differentiation and connectivity processes, including otolith morphogenesis, chemorepulsion in olfactory bulb interneuron migration, and regeneration-related axon extension.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051965","count":2},{"id":"GO:0035385","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0032474","count":2}]},{"hash":"526690083751105923","title":"Neural development and actin remodeling","description":"Focusing on the top terms, the cluster centers on neural development processes (head involution, neural tube closure, axon guidance, multicellular organism development) and actin cytoskeleton dynamics (actin polymerization/depolymerization, ARP2/3-mediated actin nucleation, stress fiber assembly). This points to proteins involved in shaping neural structures through cytoskeletal remodeling. A few regulatory terms are present but do not undermine the core theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008258","count":2},{"id":"GO:0090311","count":1},{"id":"GO:0045886","count":1},{"id":"GO:0002625","count":1},{"id":"GO:0007275","count":1}]},{"hash":"16641086284661957","title":"Cell Polarity and Developmental Signaling","description":"The top GO terms cluster around polarity establishment and developmental signaling: epithelial apical/basal polarity, planar cell polarity/convergent extension, and regulation of Wnt signaling, with GTPase activation linking to cytoskeletal rearrangements. Some outliers (secretion terms, obsolete terms) exist, but the core theme is cell polarity linked to developmental signaling.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":2},{"id":"GO:0055114","count":2},{"id":"GO:2000821","count":1},{"id":"GO:0045198","count":1},{"id":"GO:0032782","count":1}]},{"hash":"1570421524777801727","title":"Autonomic signaling and cardiovascular regulation","description":"The GO terms are dominated by autonomic/vascular functions (epinephrine/norepinephrine\u2013mediated heart rate and blood pressure regulation, vasoconstriction, heat generation) with some nervous-system development terms, suggesting a cluster tied to nervous system signaling and autonomic control rather than a single enzymatic pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060658","count":4},{"id":"GO:0035106","count":4},{"id":"GO:0035815","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0001996","count":4}]},{"hash":"1356873231918842184","title":"Unknown","description":"The 4 proteins are annotated with a diverse set of GO terms spanning endocytosis, xenobiotic response, cholesterol biosynthesis, cell adhesion, neurotransmission, metabolism, immune signaling, and neural development, with no clear shared function. A single cohesive label cannot be inferred from these terms.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0006695","count":2},{"id":"GO:1902362","count":1},{"id":"GO:0033632","count":1}]},{"hash":"2026901843358616508","title":"Innate Immune Signaling and Leukocyte Recruitment","description":"Based on GO terms dominated by complement activation (lectin pathway), Fc-gamma receptor signaling, C-type lectin receptor signaling, leukocyte tethering/rolling, and NK cell chemotaxis, the proteins cluster around innate immune signaling and the control of leukocyte trafficking. A kidney development term appears incidental; overall the dominant theme is immune activation and leukocyte recruitment.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":1},{"id":"GO:2000502","count":1},{"id":"GO:0001867","count":1},{"id":"GO:0050901","count":1},{"id":"GO:0038094","count":1}]},{"hash":"2287088648955612029","title":"Neural Development and Axon Guidance Signaling","description":"The proteins are annotated with several GO terms tied to neural development, including regulation of axon extension, axon guidance, neural crest cell migration, hair cell differentiation, and sympathetic ganglion development, along with receptor tyrosine kinase signaling and HGF receptor pathways. While a couple of terms (complement activation, endosome localization) are less directly related, the dominant themes indicate involvement in neural development and axon guidance signaling.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0048843","count":4},{"id":"GO:1902946","count":4},{"id":"GO:2000312","count":4},{"id":"GO:0048012","count":4}]},{"hash":"521496235718629089","title":"NF-\u03baB Regulation by Ubiquitination","description":"These proteins cluster around ubiquitin-based regulation of NF-\u03baB signaling. The top GO terms include multiple ubiquitination activities (K6- and K63-linked tagging), autoubiquitination, and positive regulation of canonical NF-\u03baB transcriptional activity, together with ubiquitin-dependent protein catabolic processes. This points to a shared role in controlling NF-\u03baB pathway activation and protein turnover via ubiquitin, with possible immune-system context suggested by T cell homeostasis and spleen development terms. The lack of explicit protein\u2013protein interaction edges in this dataset does not obscure the underlying theme of ubiquitin-mediated NF-\u03baB regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0085020","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0070534","count":4}]},{"hash":"2045504726023036231","title":"ER-Golgi trafficking and Golgi organization","description":"Based on the GO terms, the proteins cluster around regulation of Golgi organization, ER-to-Golgi vesicle transport, and vesicle fusion with the Golgi, with other terms pointing to endosome transport and neuronal secretion. This combination strongly suggests a group of proteins coordinating the secretory pathway through Golgi and ER-Golgi vesicle dynamics, potentially with neuronal secretion roles. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1903358","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0033194","count":1},{"id":"GO:0048280","count":1},{"id":"GO:0061669","count":1}]},{"hash":"2088880279349602134","title":"Endomembrane organization and vesicle transport","description":"This cluster\u2019s GO terms predominantly point to membrane compartments and trafficking (endosomes, ER, nuclear envelope/membrane) and vesicle movement (synaptic vesicle transport). These shared functions suggest a common role in intracellular transport and organelle organization, with some development-related terms likely reflecting broader involvement in cellular maturation.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044655","count":1},{"id":"GO:0007032","count":1},{"id":"GO:0048489","count":1},{"id":"GO:0006998","count":1},{"id":"GO:0071763","count":1}]},{"hash":"167754106473346380","title":"Immune cell adhesion and activation","description":"The GO terms cluster around immune interactions (cell adhesion, complement activation, phagolysosome assembly) and regulation of T cells and platelets, suggesting a cohesive theme of immune cell adhesion/activation and associated signaling.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0001867","count":3},{"id":"GO:0051006","count":3},{"id":"GO:0001845","count":3},{"id":"GO:0007157","count":3}]},{"hash":"836668779231542454","title":"Ribosome Biogenesis and Translation","description":"The top GO terms cluster around core components and processes of the protein synthesis machinery: translational elongation, ribosomal large subunit biogenesis, rRNA methylation, and maintenance of translational fidelity, with related methylation events. While a few terms (biotin/cobalamin biosynthesis, glucose starvation, actin regulation) are peripheral, the dominant signal points to ribosome assembly and translation functions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990145","count":1},{"id":"GO:0006414","count":1},{"id":"GO:0032232","count":1},{"id":"GO:0009236","count":1},{"id":"GO:0070476","count":1}]},{"hash":"722442281323189908","title":"Immune activation and cytokine production","description":"This cluster is enriched for immune-related terms, including positive regulation of IL-3 and GM-CSF production, activated T cell proliferation, and cellular response to LPS, suggesting a theme of immune signaling and cytokine regulation despite some heterogeneous terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:1901925","count":3},{"id":"GO:0045401","count":3},{"id":"GO:0045425","count":3},{"id":"GO:0071222","count":3},{"id":"GO:2000811","count":3}]},{"hash":"1768004949738249324","title":"Fucose, arabinose, and rhamnose sugar catabolism","description":"Based on the top GO terms, the cluster is enriched for catabolic pathways of L-fucose, L-arabinose, and rhamnose, indicating a bacterial carbohydrate utilization module. This suggests a single theme of sugar catabolism, despite a few peripheral terms that may reflect annotation noise. The name captures the shared function best.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042355","count":2},{"id":"GO:0019569","count":2},{"id":"GO:0019301","count":2},{"id":"GO:0009615","count":1},{"id":"GO:0006412","count":1}]},{"hash":"1877244427662746738","title":"Calcium and potassium ion homeostasis","description":"These proteins cluster around core themes of ion balance and calcium signaling, highlighted by terms like stabilization of membrane potential, intracellular potassium ion homeostasis, and regulation of ER calcium ion concentration. While a few terms are peripheral or obsolete, the dominant signal across the TOP terms points to ion transport/homeostasis and calcium dynamics as the unifying function of this cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030322","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0030007","count":2},{"id":"GO:0070885","count":1},{"id":"GO:0097755","count":1}]},{"hash":"864958688591698330","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning virion assembly, telomere maintenance, immune responses, RNA processing, and chaperone activity, with no clear single theme binding them. This suggests multifunctional or inconsistently annotated proteins, making a cohesive label unreliable.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019068","count":3},{"id":"GO:1904851","count":3},{"id":"GO:0048291","count":3},{"id":"GO:0002842","count":3},{"id":"GO:0090666","count":3}]},{"hash":"572132514878349132","title":"Cytoplasmic translation and initiation","description":"The cluster is enriched for translation-related GO terms, especially cytoplasmic translation and translational initiation, pointing to proteins involved in protein synthesis. A related rRNA maturation term aligns with ribosome biogenesis, which fits the same overall pathway, while the osteoblast differentiation annotation is likely noise. This makes a label centered on translation a concise and representative choice.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0031365","count":1},{"id":"GO:0043686","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0000462","count":1}]},{"hash":"565091405432168647","title":"RNA Pol II Transcription Initiation and Viral Interaction","description":"The top GO terms cluster around RNA polymerase II\u2013mediated transcription, including DNA-templated transcription, transcription start site selection, and open complex formation at Pol II promoters, indicating a focus on transcription initiation. There are also terms related to early viral transcription and host antiviral regulation, which suggests involvement of viral context where Pol II transcription is modulated. Some outlier terms exist, but the dominant theme is RNA Pol II transcription initiation with viral interaction.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019085","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0001174","count":1},{"id":"GO:0001113","count":1},{"id":"GO:0010673","count":1}]},{"hash":"2301390657966520827","title":"Embryonic Morphogenesis and Chromatin Remodeling","description":"This cluster centers on developmental processes, including embryogenesis and morphogenesis, with several terms pointing to organ and tissue development (endodermal fate, cranial skeletal system development, lung induction, embryonic body morphogenesis) and chromatin-level regulation (transcription initiation-coupled chromatin remodeling, euchromatin binding). The combination suggests a regulatory module guiding developmental programs through chromatin remodeling and epigenetic control, applicable across diverse tissues and species (including cuticle patterning in larvae and cardiac-related adhesion terms). Overall, the label captures both the morphogenetic and epigenetic dimensions represented by the GO terms.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001711","count":3},{"id":"GO:0035293","count":3},{"id":"GO:0048096","count":3},{"id":"GO:0060492","count":3},{"id":"GO:0031144","count":3}]},{"hash":"2064204527227903542","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster around translation, ribosome biogenesis, and rRNA processing (translation, ribosome biogenesis, endonucleolytic cleavage in ITS1 to separate rRNA), which together point to a core function in ribosome assembly and protein synthesis. Some peripheral terms related to nucleotide phosphorylation and biosynthesis appear incidental to this main theme, but the dominant signal supports ribosome-related activity.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0009435","count":1},{"id":"GO:0015937","count":1}]},{"hash":"881299480832590549","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0031167","count":2},{"id":"GO:0090669","count":1},{"id":"GO:0031118","count":1}]},{"hash":"1910240576947506276","title":"Ribosome biogenesis and translation regulation","description":"Top terms cluster around translation and ribosome biology (translation; ribosome biogenesis; rRNA export) and translational fidelity, suggesting a focus on ribosome assembly and accurate protein synthesis; the lipid/vitamin metabolism terms appear incidental.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0045903","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0006407","count":1}]},{"hash":"137014199948124331","title":"Proteostasis and autophagy regulation","description":"This cluster centers on protein quality control and degradation pathways: deubiquitination, regulation of proteasomal activity, and aggrephagy, with supporting roles from microtubule organization for cargo transport and ER-stress\u2013related apoptotic signaling. The GO terms collectively suggest a unified theme of maintaining proteostasis and modulating autophagic/lysosomal pathways, though one outlier term (nucleotide-excision repair) is less directly connected.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070911","count":3},{"id":"GO:0031122","count":3},{"id":"GO:0016579","count":3},{"id":"GO:1905366","count":3},{"id":"GO:1901340","count":3}]},{"hash":"1627720165220676010","title":"Unknown","description":"The top GO terms are highly diverse, spanning chromatin modification, GPCR signaling, ribosome biogenesis, ubiquitination, DNA repair, imprinting, and development, with no single unifying function connecting the proteins; thus no coherent cluster label can be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061087","count":2},{"id":"GO:0007200","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0070979","count":1},{"id":"GO:0071560","count":1}]},{"hash":"1415604164356716403","title":"Calcium Transport and Signaling Regulation","description":"The GO terms cluster around calcium ion transport (cytosol to ER, Golgi release) and monoatomic/cadmium transport, along with negative regulation of calcium-dependent signaling pathways (calcineurin-NFAT) and nitric oxide signaling, plus a muscle-relaxation hint. This points to a cohesive theme of calcium handling and calcium-dependent signaling regulation within the proteins.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0099132","count":2},{"id":"GO:0019373","count":1},{"id":"GO:0010751","count":1},{"id":"GO:1903515","count":1},{"id":"GO:0070885","count":1}]},{"hash":"1657595942933488944","title":"Proteostasis and ER-associated degradation","description":"Dominant signals point to protein quality control and turnover: ribosome-associated ubiquitin-dependent degradation, cytosolic proteasome-mediated quality control, and ER-to-cytosol retrograde transport linked to ERAD. Together they indicate a focus on maintaining protein homeostasis through ubiquitin-proteasome\u2013driven degradation in cytosolic and ER contexts.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051974","count":1},{"id":"GO:0030970","count":1},{"id":"GO:0070651","count":1},{"id":"GO:1900182","count":1},{"id":"GO:0071629","count":1}]},{"hash":"1158705416688894933","title":"Pyroptosis and innate immunity cluster","description":"This cluster is driven by GO terms related to inflammatory cell death and immune signaling, notably apoptotic process, pyroptotic inflammatory response, and innate immune response, with ubiquitination suggesting regulation of these pathways. While other terms (mitotic spindle assembly, DNA repair, ribosome biogenesis) appear, the strongest common theme appears to be programmed cell death in the context of innate immunity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":1},{"id":"GO:0070269","count":1},{"id":"GO:0016567","count":1},{"id":"GO:1990001","count":1},{"id":"GO:0045087","count":1}]},{"hash":"931948094912696970","title":"Neuronal signaling and synaptic regulation","description":"This cluster's top GO terms strongly point to neuronal signaling and synaptic function, e.g., positive regulation of AMPA receptor activity, cellular response to nerve growth factor, and synaptic vesicle uncoating. While terms also touch on broader signal transduction and metabolic pathways (PKC activation, insulin signaling, TGF-\u03b2), the neural-specific terms dominate, suggesting the cluster represents proteins involved in neural signaling and synaptic regulation.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0086098","count":2},{"id":"GO:1990051","count":2},{"id":"GO:0032005","count":2},{"id":"GO:1903898","count":2},{"id":"GO:1990090","count":2}]},{"hash":"830352491850672374","title":"GPCR-cAMP Signaling in Thermogenesis and Blood Pressure","description":"The top GO terms cluster around GPCR-mediated activation of adenylate cyclase, temperature-responsive and thermogenic processes, plus regulation of blood pressure and renal sodium handling. This points to a cohesive theme where G protein-coupled receptor signaling driving cAMP production modulates thermogenesis and cardiovascular/kidney regulation; a few unrelated terms appear as noise but do not override the dominant pattern.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0010579","count":2}]},{"hash":"439291734079727741","title":"Diverse membrane solute transporters","description":"Most of the top GO terms describe transmembrane transport of diverse substrates (sialic acid, urate, arabinose, 4-hydroxyphenylacetate, phosphate, vitamins, sodium ions) and related processes like neurotransmitter loading. This pattern suggests the cluster's proteins function as membrane transporters with broad or varied substrate specificity, rather than a single highly specific role. Therefore, the label \"Diverse membrane solute transporters\" best summarizes the cluster.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0015747","count":3},{"id":"GO:0015751","count":3},{"id":"GO:1900754","count":3}]},{"hash":"1177796307331131015","title":"Chromatin regulation and transcription control","description":"The GO terms cluster around epigenetic control of gene expression, including DNA-templated transcription, rDNA heterochromatin formation, nucleosome density regulation, and histone deacetylation. These point to chromatin remodeling and transcriptional regulation as the main theme, with a few outlier terms related to metabolism or muscle signaling.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0045820","count":2},{"id":"GO:0034983","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0060303","count":2}]},{"hash":"1984008975917963360","title":"Glucocorticoid signaling and apoptosis regulation","description":"This cluster centers on glucocorticoid pathways (nuclear receptor\u2013mediated glucocorticoid signaling and glucocorticoid catabolic process) and apoptotic signaling in response to DNA damage, with additional hints of kinase activity regulation. The dominant theme is a stress-responsive signaling axis driven by glucocorticoid signaling that can influence apoptosis, making this a coherent functional group despite a few outlier terms.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006713","count":1},{"id":"GO:0008630","count":1},{"id":"GO:1900740","count":1},{"id":"GO:0010482","count":1},{"id":"GO:0043154","count":1}]},{"hash":"1671296875280295010","title":"Cardiac development and heart valve morphogenesis","description":"This cluster\u2019s GO terms are strongly centered on cardiac development and morphogenesis, including outflow tract formation, atrial/ventricular chamber formation, and heart valve development, suggesting the proteins cooperate in heart formation. A few terms relate to other lineages like osteoblast regulation or neuronal differentiation, but the dominant signal is cardiac development. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045668","count":3},{"id":"GO:0060766","count":3},{"id":"GO:0045663","count":2},{"id":"GO:0061309","count":2},{"id":"GO:0035910","count":2}]},{"hash":"1732510808720777079","title":"Dopaminergic synaptic signaling and drug response","description":"The top GO terms cluster around neural signaling and addiction-related behavior: dopaminergic synaptic transmission, behavioral responses to cocaine and morphine, and ERK cascade regulation, suggesting plasticity in dopaminergic pathways. Some terms (visual perception/learning) may reflect broader CNS functions, but the overall theme points to brain signaling and drug-response processes.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0071380","count":3}]},{"hash":"2232998560268509369","title":"Cardiac Development and Heart Morphogenesis","description":"The dominant GO terms point to cardiac development and morphogenesis, including atrial and ventricular formation, outflow tract morphogenesis, and heart-rate regulation. A few terms relate to other organs, but the strongest signal is cardiac development, supporting this label.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045663","count":3},{"id":"GO:0061309","count":3},{"id":"GO:0035910","count":3},{"id":"GO:0021892","count":3},{"id":"GO:2000793","count":3}]},{"hash":"1984089902376357598","title":"RNA and protein methylation enzymes","description":"These proteins are enriched for methylation-related GO terms, including rRNA methylation, tRNA methylation, and various protein methylation processes (peptidyl-lysine dimethylation, N-terminal trimethylation, and histone methylation). The core theme is methylation modifications on RNA and proteins, with some peripheral metabolic terms. Confidence: High","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0009236","count":1},{"id":"GO:0070476","count":1},{"id":"GO:0043985","count":1},{"id":"GO:0018027","count":1}]},{"hash":"2184216782599888169","title":"Cardiac morphogenesis with neural crest contributions","description":"These proteins are tied to heart development: atrial and left ventricle formation, valve development, and outflow tract morphogenesis, with references to neural crest\u2013derived contributions and aortic morphogenesis. While a few terms relate to neural differentiation, the preponderance of cardiac-specific GO terms suggests the cluster represents cardiac morphogenesis programs, possibly involving neural crest\u2013related lineages.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048712","count":3},{"id":"GO:2001038","count":3},{"id":"GO:0045663","count":2},{"id":"GO:0061309","count":2},{"id":"GO:0035910","count":2}]},{"hash":"346636254366866779","title":"Neural Vision and Dopaminergic Signaling","description":"The cluster\u2019s strongest terms cluster around visual perception and learning, dopaminergic synaptic transmission, and behavioral responses to cocaine, pointing to neural pathways that integrate vision with reward signaling and dopamine-mediated processing. Incidental terms related to development or non-neural processes appear less central to the dominant theme.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0007507","count":3}]},{"hash":"2234208367205994649","title":"Lymphocyte development and NF-kappaB signaling","description":"The frequent GO terms point to immune system development and signaling, including V(D)J recombination, TNF-mediated signaling, and NF-kappaB activation, all hallmarks of T and B cell maturation and regulation. Ubiquitin-dependent protein turnover also appears, consistent with signaling control in lymphocytes. A few terms on embryonic development and cardiovascular development are present but likely reflect broader annotations; the core theme remains lymphocyte development and immune signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0033092","count":2},{"id":"GO:0097070","count":2},{"id":"GO:0039536","count":2},{"id":"GO:0042787","count":2}]},{"hash":"815612288433308435","title":"Nucleotide metabolism and salvage","description":"The top GO terms cluster around ADP/AMP/CDP biosynthesis, nucleotide phosphorylation, and interconversion (purine ribonucleotide interconversion, AMP salvage, ITP/GTP metabolism), indicating a shared function in nucleotide biosynthesis and nucleotide phosphorylation. While terms for brain and liver development appear, these are broad annotations and the core signal is nucleotide metabolism.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0015951","count":3},{"id":"GO:0046939","count":3},{"id":"GO:0006172","count":3},{"id":"GO:0046940","count":3}]},{"hash":"720244451103435628","title":"Ubiquitin-Proteasome Regulation","description":"The top GO terms are dominated by ubiquitination (K48- and K63-linked), ubiquitin-dependent protein catabolic process, and autoubiquitination, with a note on negative regulation of proteasomal degradation, indicating a focus on the ubiquitin-proteasome system and its regulation; metal/heme-related terms appear peripheral. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070936","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0010044","count":1}]},{"hash":"1492091475737461577","title":"Unknown","description":"No GO terms or network connections are evident to tie these proteins to a common function, so a reliable label cannot be inferred.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1271212441490344651","title":"Neuromuscular synaptic vesicle trafficking","description":"The cluster\u2019s GO terms cluster around neuromuscular junction function, with strong signals for regulation of neuromuscular transmission, SNARE complex disassembly, and synaptic assembly at the NMJ, all pointing to vesicle fusion and trafficking at the synapse. Supporting membrane remodeling processes (membrane fission, endosomal microautophagy) reinforce this vesicle-targeted theme, while a few terms reflect broader cellular contexts (mitochondrial assembly, oxidative stress) that are less central to NMJ vesicle dynamics. Overall, the dominant theme is neuromuscular synaptic vesicle trafficking.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:1900074","count":3},{"id":"GO:0035494","count":3},{"id":"GO:0045887","count":3},{"id":"GO:0034551","count":3},{"id":"GO:0034599","count":3}]},{"hash":"785601534332776378","title":"Programmed cell death and innate immunity","description":"The top terms are dominated by apoptosis, pyroptosis, and innate immune response, with ubiquitination as a key regulatory process, suggesting a cluster centered on regulated cell death and immune signaling. The presence of mitotic spindle assembly and plasmid maintenance appears as outliers that don\u2019t alter the overall theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0070269","count":3},{"id":"GO:0016567","count":3},{"id":"GO:1990001","count":3},{"id":"GO:0045087","count":3}]},{"hash":"2135311674209535258","title":"Ubiquitin-Dependent Immune Regulation","description":"The cluster is dominated by ubiquitination-related terms (protein ubiquitination, K48-linked ubiquitination, ubiquitin-dependent protein catabolic process) and immune signaling (innate immune response, negative regulation of RIG-I signaling, T cell homeostasis, spleen development), suggesting a function in ubiquitin-mediated regulation of immune pathways. A few trafficking-related terms appear as well, but the main theme centers on ubiquitin-driven control of immune responses.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0060816","count":2},{"id":"GO:0035372","count":2},{"id":"GO:0039536","count":2}]},{"hash":"1989664579135379803","title":"Mitotic Cell Cycle Regulation","description":"This cluster is dominated by GO terms related to the cell cycle and mitosis, including cell cycle regulation, mitotic spindle elongation, mitotic actomyosin ring maturation, and negative regulation of CDK activity and related kinase signaling. While one term about mitochondrial translation appears, the overall theme points to coordinated control of mitosis and cell-cycle progression, with emphasis on regulation of kinase activities that drive mitotic events.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0032543","count":1},{"id":"GO:1902846","count":1},{"id":"GO:0018192","count":1},{"id":"GO:1902406","count":1}]},{"hash":"43785223051048040","title":"Ammonium Transport and Nitrogen Utilization","description":"Top GO terms cluster around ammonium transport and nitrogen utilization, including transepithelial ammonium transport, ammonium transmembrane transport, and regulation of nitrogen utilization, with methylammonium transport also present. While a few terms touch on related metabolic or growth stress responses, the core theme is nitrogen handling and ammonium transport. This makes the label a concise, representative summary of the cluster\u2019s function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060586","count":1},{"id":"GO:0080181","count":1},{"id":"GO:0015670","count":1},{"id":"GO:0070634","count":1},{"id":"GO:0072488","count":1}]},{"hash":"1706986908696782750","title":"Immune signaling regulators","description":"Proteins in this cluster are tied to modulation of immune responses, with GO terms covering T cell activation, NK cell cytotoxicity, macrophage activation, phagocytosis, Fc-epsilon receptor signaling, and CD40 signaling, suggesting a shared role in regulating immune cell activation and signaling pathways.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050867","count":1},{"id":"GO:2000350","count":1},{"id":"GO:0060370","count":1},{"id":"GO:0045663","count":1},{"id":"GO:0050712","count":1}]},{"hash":"1718938452893962688","title":"Unknown","description":"The top GO terms are highly diverse, including immune signaling (T cell proliferation, IL-3 and GM-CSF production), cellular responses to LPS, and unrelated plant or development terms (pollen recognition, placenta-related differentiation) or obsolete oxidative stress terms. With only 3 proteins and no edges linking them into a common function, there isn\u2019t a clear shared theme to name the cluster meaningfully.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901925","count":1},{"id":"GO:0045401","count":1},{"id":"GO:0045425","count":1},{"id":"GO:0071222","count":1},{"id":"GO:2000811","count":1}]},{"hash":"1428555867769747525","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006293","count":2},{"id":"GO:0006296","count":2},{"id":"GO:0042769","count":2},{"id":"GO:0006295","count":2},{"id":"GO:0006294","count":2}]},{"hash":"1799652351353539143","title":"Cardiac Action Potential Regulation","description":"This cluster\u2019s top GO terms are dominated by cardiac electrophysiology: regulation of atrial cardiac muscle cell membrane repolarization, regulation of membrane depolarization during cardiac muscle cell action potential, and cardiac muscle cell action potential involved in contraction. While a few terms point to unrelated processes (lipid catabolism, cortisol biosynthesis, plant signaling), the strongest, recurring theme is cardiac membrane excitability and action potential regulation, suggesting a core cardiac electrophysiology function for this group.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060372","count":1},{"id":"GO:0046475","count":1},{"id":"GO:1900827","count":1},{"id":"GO:2000031","count":1},{"id":"GO:0090501","count":1}]},{"hash":"2125423542017355018","title":"Neural development and axon guidance signaling","description":"The top GO terms cluster around nervous system development and axon guidance, highlighted by Roundabout (ROBO) and Smoothened (SHH) signaling pathways and ERK cascade regulation. While other development terms appear, the strongest theme is neural development and guidance signaling, suggesting the proteins participate in neuronal pathfinding and related signaling networks.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035385","count":2},{"id":"GO:0007224","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0002551","count":2}]},{"hash":"1066107802393012372","title":"Vesicle trafficking and secretion regulation","description":"The top GO terms cluster around membrane trafficking and secretory processes\u2014SNARE complex disassembly and regulation of vacuole fusion point to vesicle cycling, while Cvt pathway targeting and degranulation-related terms further support secretion-related roles. A few neural/developmental terms appear as outliers, but the core signals suggest vesicle trafficking/secretion dynamics.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090324","count":3},{"id":"GO:0060684","count":2},{"id":"GO:0035494","count":2},{"id":"GO:0048714","count":2},{"id":"GO:1905244","count":2}]},{"hash":"695277559457322563","title":"Viral integration and replication in host","description":"The terms cluster around the viral life cycle within a host: entry into the nucleus, integration of viral DNA into the host genome, proviral latency, genome replication, and eventual viral release. Additional terms reflect viral strategies to manipulate host gene expression and RNA silencing pathways, which are common viral immune-evasion tactics. A cohesive theme is thus viral-host interactions centered on genome integration, replication, and latency.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039657","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0015074","count":1}]},{"hash":"934177160337486717","title":"Organ and neural development","description":"The top GO terms point to development across multiple organs (retina/eye, heart, liver, brain regions) and neural connectivity, indicating a broad developmental program with emphasis on neural and organogenesis processes. Some terms appear as outliers (e.g., mucilage biosynthesis), but the prevailing theme is organismal development.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0072095","count":1}]},{"hash":"1212520539158134843","title":"Immune signaling and antigen presentation","description":"This cluster centers on the ubiquitin-proteasome system (deubiquitination and proteasome assembly) and antigen processing/presentation via MHC I (TAP-dependent), alongside multiple immune receptor signaling pathways (T cell receptor, Fc-epsilon receptor, C-type lectin receptor) and TNF signaling, indicating a cohesive immune-processing/signaling module. Peripheral terms like salt stress or Wnt regulation appear incidental to this core function.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":3},{"id":"GO:0080129","count":3},{"id":"GO:0002479","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0038095","count":3}]},{"hash":"1832866290719229216","title":"Transmembrane transporter proteins","description":"GO terms show diverse transmembrane transport activities (vitamins, xenobiotics, ions, sugars, and neurotransmitter loading), indicating these proteins function as membrane transporters for a variety of substrates. The common theme is transport across membranes rather than a single catalytic function, justifying a transporter-focused label.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0042908","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0098700","count":2}]},{"hash":"1802609874329753903","title":"Ubiquitin-mediated proteolysis and signaling","description":"The cluster is driven by GO terms related to autoubiquitination, ubiquitin-dependent degradation, and specific ubiquitin linkages (e.g., K6), alongside activation/regulation of NF-\u03baB and JNK signaling; histone modification terms may reflect chromatin-associated roles of ubiquitination, but the core theme appears to be ubiquitin-mediated protein turnover and signaling.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:0090073","count":2},{"id":"GO:0036205","count":2},{"id":"GO:0070512","count":2},{"id":"GO:0042787","count":2}]},{"hash":"452791963675379580","title":"Proteostasis and autophagy regulation","description":"This cluster centers on protein quality control, with terms for ERAD/unfolded protein maintenance, deubiquitination, proteasomal degradation, and aggrephagy, indicating management of proteostasis via degradation and selective autophagy. Some vesicle and calcium signaling terms appear, but the dominant theme ties to protein homeostasis.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904378","count":3},{"id":"GO:0070911","count":2},{"id":"GO:0031122","count":2},{"id":"GO:0016579","count":2},{"id":"GO:1905366","count":2}]},{"hash":"754553682805852664","title":"Calcium-Driven Multisystem Development","description":"The top GO terms point to calcium signaling (calcineurin-NFAT cascade; detection of calcium ion) together with developmental processes in Schwann cells, skeletal muscle, blood vessels, and brain (substantia nigra). This suggests a common theme of calcium-regulated differentiation across multiple tissues, hence the label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905205","count":1},{"id":"GO:0033173","count":1},{"id":"GO:0014044","count":1},{"id":"GO:0005513","count":1},{"id":"GO:0042220","count":1}]},{"hash":"1334467756906845538","title":"Unknown","description":"The GO terms show a mix of stress response, development, signaling, metabolism, and apoptosis with no unifying function across the proteins; there are no interactions to define a specific pathway, so a coherent cluster label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042542","count":1},{"id":"GO:0001700","count":1},{"id":"GO:0016485","count":1},{"id":"GO:0048011","count":1},{"id":"GO:0043029","count":1}]},{"hash":"413159800233660349","title":"Unknown","description":"The GO terms span metabolism, neural development, and host\u2013pathogen interaction with no clear, single shared function across the three proteins; the terms are too diverse to infer a cohesive role for the cluster. ","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016139","count":1},{"id":"GO:2000535","count":1},{"id":"GO:0006004","count":1},{"id":"GO:0035860","count":1},{"id":"GO:0060686","count":1}]},{"hash":"1633396197071125405","title":"Embryonic development and organogenesis","description":"Based on the top GO terms, the proteins cluster around broad embryonic development and tissue differentiation processes (placenta/placental trophoblast differentiation, endocrine system development, left-right patterning, cartilage morphogenesis, EMT in heart development), suggesting a cohesive theme of developmental biology rather than a single specific pathway.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060972","count":2}]},{"hash":"1775304013513004273","title":"Notch-regulated B cell differentiation","description":"These proteins show strong enrichment for B cell\u2013lineage terms (marginal zone B cell differentiation, pre-B cell differentiation, positive regulation of B cell differentiation) and for positive regulation of Notch signaling, suggesting a role in Notch-mediated B cell development. Other terms like calcium transport to the ER and epoxygenase P450 are present but less central to this theme, so the core connection is Notch-regulated B cell differentiation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":2},{"id":"GO:0002315","count":2},{"id":"GO:0007386","count":2},{"id":"GO:0002329","count":1},{"id":"GO:0019373","count":1}]},{"hash":"1749847667936595902","title":"Mitotic DNA replication machinery","description":"The cluster\u2019s top GO terms are centered on mitotic DNA replication, including preinitiation complex assembly, replication initiation, and elongation, with explicit mentions of the GINS complex and related replication activities. A few actin-related processes appear (Arp2/3, actin cortical patch) which may reflect either multifunctional components or annotation noise, but the dominant signal points to components involved in initiating and carrying out DNA replication during mitosis. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902977","count":1},{"id":"GO:1902969","count":1},{"id":"GO:1902983","count":1},{"id":"GO:0001833","count":1},{"id":"GO:0032508","count":1}]},{"hash":"707640842485954664","title":"Neuronal Synaptic Signaling","description":"Based on GO terms dominated by synaptic processes\u2014synaptic vesicle uncoating, AMPA receptor activity, NGF response, and related neuronal signaling pathways\u2014the cluster most coherently maps to neuronal synaptic transmission and plasticity. Other terms reflect broader signaling contexts but do not shift the primary theme away from synaptic function.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0086098","count":3},{"id":"GO:1990051","count":3},{"id":"GO:0032005","count":3},{"id":"GO:1903898","count":3},{"id":"GO:1990090","count":3}]},{"hash":"1575278245233860175","title":"Hedgehog signaling and trafficking","description":"The strongest signal is Hedgehog pathway activity (GO:0007224, smoothened signaling pathway), suggesting these proteins are related to Hedgehog signaling; the accompanying terms for endocytosis and Golgi localization imply roles in trafficking of signaling components, which fits with Hedgehog signaling requiring controlled receptor processing and trafficking. Additional terms reference broader regulatory processes (autoubiquitination, ER-stress\u2013related apoptotic signaling, and growth regulation), indicating a mix of regulatory and trafficking aspects around Hedgehog signaling. Overall, the cluster appears best described as Hedgehog signaling components involved in membrane trafficking and regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":2},{"id":"GO:1902236","count":1},{"id":"GO:0006897","count":1},{"id":"GO:1902499","count":1},{"id":"GO:0045792","count":1}]},{"hash":"2088700942176251862","title":"Nitrate and peptide transporters with hormone signaling","description":"The Top Terms show several substrate transport processes (nitrate, dipeptide, oligopeptide, sialic acid) and nitrate-related responses, along with plant hormone signaling terms (auxin-activated pathway, gibberellin homeostasis) and herbicide response. This pattern suggests a small cluster of transporter proteins involved in nutrient uptake that are modulated by plant hormone signaling and stress responses. Confidence: Medium","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0009734","count":2},{"id":"GO:0035672","count":2},{"id":"GO:0010336","count":2},{"id":"GO:0080055","count":2}]},{"hash":"114750517618199647","title":"Retroviral life cycle","description":"The top terms point to key retroviral processes: virion assembly, DNA integration, proviral latency, ESCRT-mediated budding, and viral release, indicating a cluster of proteins involved in the viral life cycle and host interactions. Some rRNA processing and splicing terms may reflect host machinery hijacked during infection, but the retroviral processes dominate the signal.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":1},{"id":"GO:0000469","count":1},{"id":"GO:0019068","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0039702","count":1}]},{"hash":"557071675885792350","title":"Vascular inflammation and coagulation signaling","description":"The cluster centers on processes tying blood coagulation and platelet function to vascular/inflammatory signaling: platelet aggregation, fibrin clot formation, complement activation, IL-1\u2013mediated responses, and ERK signaling, all pointing to a coordinated vascular inflammatory/coagulation program. A few standalone terms (endothelial differentiation, UV-B response, arabinose metabolism) appear as lesser signals, but the dominant theme is coagulation and vascular inflammation.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0001867","count":1},{"id":"GO:0071347","count":1},{"id":"GO:0072378","count":1},{"id":"GO:0045446","count":1}]},{"hash":"1621693277884374710","title":"Neuronal Axon Guidance and Projection","description":"The GO terms are dominated by axon guidance and neuron projection processes (sympathetic neuron projection guidance, neural crest cell migration, semaphorin-plexin signaling in axon guidance, axonal fasciculation, projection extension, branchiomotor neuron guidance, trigeminal nerve organization). A couple of terms about endosome localization and complement activation are less central and do not define the core theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097491","count":3},{"id":"GO:0036486","count":3},{"id":"GO:1902287","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0097490","count":3}]},{"hash":"1891376285561296265","title":"Innate Immune Activation and Cytokine Signaling","description":"This cluster is dominated by GO terms related to activation of innate immune cells (myeloid dendritic cells), cytokine production and signaling (TNF, TLR4, TGF-beta pathways), and regulation of B and T cell processes. Despite one outlier term (neuronal differentiation), the overall pattern points to immune activation and inflammatory signaling as the core function of the cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002277","count":1},{"id":"GO:1900017","count":1},{"id":"GO:0002906","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0033209","count":1}]},{"hash":"125332036770793157","title":"Unknown","description":"The listed GO terms are heterogeneous\u2014ranging from metabolism and glycosylation to development and signaling\u2014with no clear shared function linking the proteins, so a cohesive label cannot be assigned.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030166","count":1},{"id":"GO:0006256","count":1},{"id":"GO:0043123","count":1},{"id":"GO:0046712","count":1},{"id":"GO:0060465","count":1}]}]