{"hash":"678017413025709652","title":"DNA replication and chromatin maintenance under stress","description":"The top GO terms are dominated by DNA replication and DNA biosynthetic processes, plus CENP-A\u2013containing chromatin assembly and translesion synthesis, indicating a core of nuclear DNA metabolism and chromosome maintenance. The accompanying terms reference cellular responses to toxic substances, xenobiotics, ethanol, and oxidative stress, suggesting this cluster integrates DNA replication/repair with stress response pathways. The presence of spermatid development hints at germline chromatin remodeling. Together, the cluster likely represents DNA replication/maintenance and chromatin organization functions in a stress context.","confidence":"High","size":18,"edges":120,"triangles":501,"max_degree":17,"top_function":"DNA replication","members":[{"accession":"XP_031298690.1","go_terms":["GO:0061738","GO:0031117","GO:0051260","GO:0030420","GO:2001171","GO:0034214","GO:1903862","GO:0032968","GO:0070842","GO:0001824","GO:0006260","GO:0034551","GO:0070682","GO:0033314","GO:0032979","GO:0051013","GO:0046034","GO:1901800","GO:1990171","GO:0016485","GO:0045899","GO:0030968","GO:0006272","GO:0070987","GO:0043335","GO:0070676","GO:0070370","GO:1903007","GO:0090261","GO:0070914","GO:0061641","GO:0061166","GO:1903715","GO:0051301","GO:0006888","GO:0045053","GO:0001319","GO:0035494","GO:0019079","GO:0070414","GO:0097352","GO:0071218","GO:0016562","GO:2000158","GO:0070389","GO:0018279","GO:0006406","GO:0051131","GO:0048219","GO:0030433","GO:1903724","GO:0034599","GO:0090296","GO:0072389","GO:0045041","GO:0016558","GO:0000733","GO:0070407","GO:0070651","GO:0071712","GO:0035617","GO:0090305","GO:0071897","GO:1900264","GO:0006261","GO:0007062"]},{"accession":"XP_064334682.1","go_terms":["GO:0006260","GO:0030163","GO:0030494","GO:0015979","GO:0006270","GO:0051301","GO:0061738","GO:0031117","GO:0051260","GO:0030420","GO:2001171","GO:0034214","GO:1903862","GO:0032968","GO:0070842","GO:0001824","GO:0034551","GO:0070682","GO:0033314","GO:0032979","GO:0051013","GO:0046034","GO:1901800","GO:1990171","GO:0016485","GO:0045899","GO:0030968","GO:0006272","GO:0070987","GO:0043335","GO:0070676","GO:0070370","GO:1903007","GO:0090261","GO:0070914","GO:0061641","GO:0061166","GO:1903715","GO:0006888","GO:0045053","GO:0001319","GO:0035494","GO:0019079","GO:0070414","GO:0097352","GO:0071218","GO:0016562","GO:2000158","GO:0070389","GO:0018279","GO:0006406","GO:0051131","GO:0048219","GO:0030433","GO:1903724","GO:0034599","GO:0090296","GO:0072389","GO:0045041","GO:0016558","GO:0000733","GO:0070407","GO:0070651","GO:0071712","GO:0035617","GO:0090305","GO:0071897","GO:0039520","GO:0019082","GO:0039694","GO:0006351","GO:0006396","GO:1900264","GO:0006261","GO:0007062"]},{"accession":"XP_064344610.1","go_terms":["GO:0006307","GO:0006306","GO:0071479","GO:0045471","GO:0071407","GO:0006281","GO:0009636","GO:0051593","GO:2000781","GO:0043281","GO:0051409","GO:0034599","GO:0060644"]},{"accession":"XP_010987612.1","go_terms":["GO:0006310","GO:0010212","GO:0006281","GO:0009432","GO:0000722","GO:2000269","GO:0071480","GO:0009636","GO:0051106","GO:0090267","GO:0036297","GO:0000732","GO:0007294","GO:0007066","GO:0007533","GO:0007141","GO:0010165","GO:0001541","GO:1990918","GO:0009949","GO:0051260","GO:0007129","GO:0000707","GO:0001556","GO:1990426","GO:0072757","GO:0000709","GO:0072719","GO:0010569","GO:0072711","GO:0007286","GO:0042148","GO:0007131","GO:0007130","GO:1904631","GO:0090656","GO:0009951","GO:0045003","GO:0006268","GO:0001832","GO:0030491","GO:0042493","GO:0030717","GO:1990414","GO:0001932","GO:0071140","GO:0007127","GO:0006260","GO:0032508","GO:0000730","GO:0006412","GO:0071897","GO:0006276"]},{"accession":"XP_010974906.2","go_terms":["GO:0006468","GO:0007623","GO:0000725","GO:0006355","GO:0070297","GO:0042754","GO:0006351","GO:0009649","GO:0000722","GO:2000269","GO:0071480","GO:0009636","GO:0051106","GO:0090267","GO:0036297","GO:0000732","GO:0007294","GO:0007066","GO:0007533","GO:0007141","GO:0010165","GO:0001541","GO:1990918","GO:0009949","GO:0051260","GO:0007129","GO:0000707","GO:0001556","GO:1990426","GO:0072757","GO:0000709","GO:0072719","GO:0010569","GO:0072711","GO:0007286","GO:0042148","GO:0007131","GO:0007130","GO:1904631","GO:0090656","GO:0009951","GO:0045003","GO:0006268","GO:0001832","GO:0030491","GO:0042493","GO:0030717","GO:1990414","GO:0001932","GO:0071140","GO:0016539","GO:0006260","GO:0006269","GO:0006276"]},{"accession":"XP_010981877.1","go_terms":["GO:0006310","GO:0010212","GO:0006281","GO:0009432","GO:0000722","GO:2000269","GO:0071480","GO:0009636","GO:0051106","GO:0090267","GO:0036297","GO:0000732","GO:0007294","GO:0007066","GO:0007533","GO:0007141","GO:0010165","GO:0001541","GO:1990918","GO:0009949","GO:0051260","GO:0007129","GO:0000707","GO:0001556","GO:1990426","GO:0072757","GO:0000709","GO:0072719","GO:0010569","GO:0072711","GO:0007286","GO:0042148","GO:0007131","GO:0007130","GO:1904631","GO:0090656","GO:0009951","GO:0045003","GO:0006268","GO:0001832","GO:0030491","GO:0042493","GO:0030717","GO:1990414","GO:0001932","GO:0071140","GO:0007127","GO:0006260","GO:0032508","GO:0000730","GO:0006412","GO:0071897","GO:0006276"]},{"accession":"XP_010988724.1","go_terms":["GO:0006468","GO:0007623","GO:0000725","GO:0006355","GO:0070297","GO:0042754","GO:0006351","GO:0009649","GO:0000722","GO:2000269","GO:0071480","GO:0009636","GO:0051106","GO:0090267","GO:0036297","GO:0000732","GO:0007294","GO:0007066","GO:0007533","GO:0007141","GO:0010165","GO:0001541","GO:1990918","GO:0009949","GO:0051260","GO:0007129","GO:0000707","GO:0001556","GO:1990426","GO:0072757","GO:0000709","GO:0072719","GO:0010569","GO:0072711","GO:0007286","GO:0042148","GO:0007131","GO:0007130","GO:1904631","GO:0090656","GO:0009951","GO:0045003","GO:0006268","GO:0001832","GO:0030491","GO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