{"hash":"1545925885580603861","title":"Cofactor and tRNA Modification Biosynthesis","description":"This cluster centers on biosynthetic processes for cofactors (menaquinone, molybdopterin, protoporphyrinogen/heme) and multiple tRNA modification pathways (methylation, queuosine biosynthesis) alongside lipoylation, suggesting a cohesive theme of cofactor assembly and RNA modification rather than a single enzyme family. Antibiotic response appears peripheral but does not define the core function.","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"members":[{"accession":"XP_010978415.3","go_terms":["GO:0018339","GO:0006400","GO:1990145","GO:0006777","GO:0009234","GO:0046677","GO:0042426","GO:0009107","GO:0009102","GO:0030488","GO:0006782","GO:0070475","GO:0009249","GO:0009228","GO:0008616","GO:0018189","GO:0019475"]},{"accession":"XP_064332444.1","go_terms":["GO:0030324","GO:0017000","GO:0046677","GO:0042574","GO:0009710","GO:0045150","GO:0006729","GO:0042438","GO:0008207","GO:0055114","GO:0071768","GO:0042619","GO:0031427","GO:0030497","GO:0006355","GO:0008209","GO:0030148","GO:0006710","GO:0042572","GO:0042761","GO:0042376","GO:0006666","GO:0006704","GO:0006703","GO:0002138","GO:0061370","GO:0006706","GO:0030435","GO:0042208","GO:1902321"]},{"accession":"XP_010981878.1","go_terms":["GO:0010204","GO:0070231","GO:0006621","GO:0015031","GO:0002369"]},{"accession":"XP_010977054.2","go_terms":[]},{"accession":"XP_031320249.1","go_terms":["GO:0023041","GO:0007420"]},{"accession":"XP_064348815.1","go_terms":["GO:0003384","GO:0006490","GO:0007377","GO:0006487"]},{"accession":"XP_064338293.1","go_terms":[]},{"accession":"XP_010980311.1","go_terms":["GO:0009306"]},{"accession":"XP_010983921.1","go_terms":[]}],"graph":[["XP_010977054.2","XP_010981878.1",0.902],["XP_010977054.2","XP_064338293.1",0.812],["XP_010977054.2","XP_064348815.1",0.646],["XP_064332444.1","XP_010981878.1",0.546],["XP_064348815.1","XP_010980311.1",0.829],["XP_010981878.1","XP_010978415.3",0.617],["XP_010981878.1","XP_010983921.1",0.591]],"all_go_terms":{"GO:0070475":1,"GO:0046677":2,"GO:0009234":1,"GO:0018339":1,"GO:0006782":1,"GO:0006777":1,"GO:0030488":1,"GO:0009249":1,"GO:0008616":1,"GO:0042426":1,"GO:0009228":1,"GO:0018189":1,"GO:0006400":1,"GO:0019475":1,"GO:1990145":1,"GO:0009102":1,"GO:0009107":1,"GO:0006706":1,"GO:0042438":1,"GO:0042572":1,"GO:0002138":1,"GO:0071768":1,"GO:0042574":1,"GO:0030324":1,"GO:0009710":1,"GO:0006704":1,"GO:0030435":1,"GO:0006710":1,"GO:0006666":1,"GO:0045150":1,"GO:0042761":1,"GO:0042376":1,"GO:0031427":1,"GO:0061370":1,"GO:0042619":1,"GO:0006355":1,"GO:0008207":1,"GO:0017000":1,"GO:0030148":1,"GO:0008209":1,"GO:0030497":1,"GO:0042208":1,"GO:0006729":1,"GO:1902321":1,"GO:0055114":1,"GO:0006703":1,"GO:0015031":1,"GO:0002369":1,"GO:0070231":1,"GO:0006621":1,"GO:0010204":1,"GO:0023041":1,"GO:0007420":1,"GO:0003384":1,"GO:0006487":1,"GO:0006490":1,"GO:0007377":1,"GO:0009306":1},"recipe_readded":[]}