{"hash":"1301660557102565133","title":"Heme, cobalamin, and sphingolipid biosynthesis cluster","description":"The top terms cluster around multiple biosynthetic pathways, especially heme (porphyrinogen IX and heme biosynthesis), cobalamin biosynthesis, and sphingolipid (sphinganine) biosynthesis, with additional lipid-related and amino acid biosynthesis signals (fatty acid transport, L-aspartate). This suggests a metabolic module dedicated to producing cofactors and lipid components, rather than a single signaling or regulatory function. The presence of a DNA-templated transcription term hints at regulatory proteins in the same cluster, but the strongest, shared signal is biosynthesis/metabolism. A defense-related term appears but seems secondary to the core metabolic theme.","confidence":"Medium","size":23,"edges":223,"triangles":1237,"max_degree":22,"top_function":"DNA-templated transcription","members":[{"accession":"XP_010996979.1","go_terms":["GO:0070179","GO:0019499","GO:0009310","GO:0046360","GO:0043278","GO:0018871","GO:0043418","GO:0006565","GO:0006535","GO:0019295","GO:0000162","GO:0070814","GO:0042866","GO:0019346","GO:0019343","GO:0009088","GO:0070689","GO:0009097"]},{"accession":"XP_031300934.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103","GO:0042541","GO:0035162","GO:0030218","GO:0048821","GO:0001666"]},{"accession":"XP_031309987.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_064337236.1","go_terms":["GO:0070179","GO:0019499","GO:0009310","GO:0046360","GO:0043278","GO:0018871","GO:0043418","GO:0006565","GO:0006535","GO:0019295","GO:0000162","GO:0070814","GO:0042866","GO:0019346","GO:0019343","GO:0009088","GO:0070689","GO:0009097"]},{"accession":"XP_064346303.1","go_terms":["GO:0009116","GO:0019464","GO:0055114","GO:0006545","GO:0006567","GO:0006570","GO:0006569"]},{"accession":"XP_010973277.2","go_terms":["GO:0044268","GO:0019552","GO:0042759","GO:2001295","GO:0006633"]},{"accession":"XP_010973818.1","go_terms":["GO:0044268","GO:0019552","GO:0042759","GO:2001295","GO:0006633"]},{"accession":"XP_010981902.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_010983678.2","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362","GO:0042541","GO:0035162","GO:0030218","GO:0048821","GO:0001666"]},{"accession":"XP_010984704.1","go_terms":["GO:0070179","GO:0019499","GO:0009310","GO:0046360","GO:0043278","GO:0018871","GO:0043418","GO:0006565","GO:0006535","GO:0019295","GO:0000162","GO:0070814","GO:0042866","GO:0019346","GO:0019343","GO:0009088","GO:0070689","GO:0009097"]},{"accession":"XP_010984888.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_010984433.1","go_terms":["GO:0009236","GO:0006541","GO:0018108","GO:0051782","GO:0045226","GO:0007049","GO:0009103","GO:0006614","GO:0006616","GO:0006617","GO:0006461","GO:0051301","GO:0044781"]},{"accession":"XP_010990993.2","go_terms":["GO:0000288","GO:0045901","GO:0045903","GO:0014009","GO:0002184","GO:0001514","GO:0046677","GO:0070125","GO:1902802","GO:2000767","GO:0032790","GO:0006413","GO:0006412","GO:0006449","GO:0019079","GO:0001172","GO:0006415"]},{"accession":"XP_010992574.2","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0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