{"hash":"331059470831051371","title":"RNA Splicing and Translation Regulation","description":"The top GO terms cluster around both mRNA processing (positive/negative regulation of splicing via spliceosome, small-subunit processome assembly) and translation control (eIF4F complex assembly, regulation of translational initiation, translation reinitiation, and stress-related mRNA stability). This suggests a cohesive module of proteins involved in post-transcriptional gene regulation, linking RNA maturation with initiation/reinitiation of translation and stress responses, rather than a single pathway.","confidence":"High","size":15,"edges":102,"triangles":419,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","members":[{"accession":"XP_062826299.1","go_terms":[]},{"accession":"XP_062840030.1","go_terms":["GO:0071028","GO:0008033","GO:0071042","GO:0016120","GO:0097222","GO:0000962","GO:0070478","GO:0000964","GO:0034475","GO:0034476","GO:2000627","GO:0071051","GO:0071035","GO:0034473","GO:0071039","GO:0071038","GO:0000467","GO:0070481","GO:0045006","GO:0010323","GO:0035928","GO:0070651","GO:0000958"]},{"accession":"XP_003221045.1","go_terms":["GO:0031564","GO:0010587","GO:1902219","GO:0031054","GO:0070934","GO:0060567","GO:1901724","GO:0006351"]},{"accession":"XP_003226986.3","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:1903608","GO:0006396"]},{"accession":"XP_008103467.1","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0071230","GO:0046011","GO:1900365","GO:0071456","GO:1900248","GO:0008069","GO:0061158","GO:0060213","GO:0007310","GO:0032869","GO:0002931","GO:0045451","GO:0000289"]},{"accession":"XP_008115209.2","go_terms":["GO:0006479","GO:0030488","GO:0032775","GO:0009452","GO:0070476","GO:0080180","GO:0009229","GO:0009228","GO:0016554","GO:0052837","GO:0034227"]},{"accession":"XP_062816194.1","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0071230","GO:0046011","GO:1900365","GO:0071456","GO:1900248","GO:0008069","GO:0061158","GO:0060213","GO:0007310","GO:0032869","GO:0002931","GO:0045451"]},{"accession":"XP_062816200.1","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0071230","GO:0046011","GO:1900365","GO:0071456","GO:1900248","GO:0008069","GO:0061158","GO:0060213","GO:0007310","GO:0032869","GO:0002931","GO:0045451"]},{"accession":"XP_062816205.1","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0071230","GO:0046011","GO:1900365","GO:0071456","GO:1900248","GO:0008069","GO:0061158","GO:0060213","GO:0007310","GO:0032869","GO:0002931","GO:0045451"]},{"accession":"XP_062816215.1","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_062817068.1","go_terms":["GO:0000244","GO:0000245","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0031990","GO:0060188","GO:0006607","GO:0006999","GO:0072417","GO:0071230","GO:0046011","GO:1900365","GO:0071456","GO:1900248","GO:0008069","GO:0061158","GO:0060213","GO:0007310","GO:0032869","GO:0002931","GO:0045451"]},{"accession":"XP_062818305.1","go_terms":["GO:0071042","GO:0001178","GO:1990120","GO:0071049","GO:0042766","GO:0006306","GO:0006301","GO:0043044","GO:0006260","GO:1902775","GO:0006268","GO:0006269","GO:0034475","GO:0034476","GO:0071051","GO:0006283","GO:0072715","GO:0006605","GO:0000462","GO:0000463","GO:0000464","GO:0000466","GO:0000467","GO:0070870","GO:0000393","GO:0000390","GO:0000716","GO:0000398","GO:0071441","GO:0016441","GO:0060303","GO:0018144","GO:1902626","GO:0016973","GO:0042255","GO:0000388","GO:0035640","GO:0006363","GO:0006369","GO:0048701","GO:0008306","GO:1900050","GO:0048026","GO:0042273","GO:1903241","GO:0019079","GO:0017038","GO:0045944","GO:0071894","GO:2000616","GO:0009432","GO:0070417","GO:1904570","GO:0010501","GO:1904574","GO:0071031","GO:0071035","GO:0071038","GO:0031047","GO:0043629","GO:0000378","GO:0016584","GO:0006311","GO:0045003","GO:0090394","GO:1990416","GO:0090669","GO:0000349","GO:0070934","GO:0009047","GO:0040022","GO:0016457","GO:0034247","GO:2000623","GO:0000350","GO:1903608","GO:0031453","GO:0045433","GO:0030423","GO:0007294","GO:0009949","GO:0030720","GO:0000335","GO:0060213","GO:0007076","GO:0045451","GO:0009951","GO:0030717","GO:0007317"]},{"accession":"XP_008113891.2","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_062835904.1","go_terms":["GO:0071028","GO:0008033","GO:0071042","GO:0016120","GO:0097222","GO:0000962","GO:0070478","GO:0000964","GO:0034475","GO:0034476","GO:2000627","GO:0071051","GO:0071035","GO:0034473","GO:0071039","GO:0071038","GO:0000467","GO:0070481","GO:0045006","GO:0010323","GO:0035928","GO:0070651","GO:0000958"]},{"accession":"XP_003224422.2","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]}],"graph":[["XP_062817068.1","XP_008113891.2",0.953],["XP_062817068.1","XP_008115209.2",0.916],["XP_062817068.1","XP_062816194.1",0.61],["XP_062817068.1","XP_062816200.1",0.619],["XP_062817068.1","XP_062816205.1",0.625],["XP_062817068.1","XP_062816215.1",0.743],["XP_062817068.1","XP_062818305.1",0.98],["XP_062817068.1","XP_062826299.1",0.861],["XP_062817068.1","XP_062835904.1",0.979],["XP_062817068.1","XP_062840030.1",0.963],["XP_062817068.1","XP_003221045.1",0.744],["XP_062817068.1","XP_003224422.2",0.879],["XP_062817068.1","XP_003226986.3",0.905],["XP_062817068.1","XP_008103467.1",0.971],["XP_062840030.1","XP_008103467.1",0.974],["XP_062840030.1","XP_008113891.2",0.9],["XP_062840030.1","XP_008115209.2",0.938],["XP_062840030.1","XP_062816194.1",0.947],["XP_062840030.1","XP_062816200.1",0.975],["XP_062840030.1","XP_062816205.1",0.964],["XP_062840030.1","XP_062816215.1",0.987],["XP_062840030.1","XP_062818305.1",0.752],["XP_062840030.1","XP_062835904.1",0.756],["XP_062840030.1","XP_003221045.1",0.962],["XP_062840030.1","XP_003224422.2",0.835],["XP_062840030.1","XP_003226986.3",0.962],["XP_008113891.2","XP_062818305.1",0.988],["XP_008113891.2","XP_062816194.1",0.989],["XP_008113891.2","XP_062816200.1",0.976],["XP_008113891.2","XP_062816205.1",0.976],["XP_008113891.2","XP_062816215.1",0.791],["XP_008113891.2","XP_062835904.1",0.943],["XP_008113891.2","XP_062826299.1",0.915],["XP_008113891.2","XP_003221045.1",0.834],["XP_008113891.2","XP_003224422.2",0.848],["XP_008113891.2","XP_003226986.3",0.949],["XP_008113891.2","XP_008103467.1",0.987],["XP_008113891.2","XP_008115209.2",0.984],["XP_062816215.1","XP_008115209.2",0.938],["XP_062816215.1","XP_062816194.1",0.875],["XP_062816215.1","XP_062816200.1",0.816],["XP_062816215.1","XP_062816205.1",0.935],["XP_062816215.1","XP_062818305.1",0.991],["XP_062816215.1","XP_062826299.1",0.974],["XP_062816215.1","XP_062835904.1",0.918],["XP_062816215.1","XP_003221045.1",0.876],["XP_062816215.1","XP_003224422.2",0.822],["XP_062816215.1","XP_003226986.3",0.979],["XP_062816215.1","XP_008103467.1",0.914],["XP_062835904.1","XP_008103467.1",0.857],["XP_062835904.1","XP_008115209.2",0.986],["XP_062835904.1","XP_062816194.1",0.947],["XP_062835904.1","XP_062816200.1",0.948],["XP_062835904.1","XP_062816205.1",0.947],["XP_062835904.1","XP_062818305.1",0.887],["XP_062835904.1","XP_062826299.1",0.962],["XP_062835904.1","XP_003221045.1",0.857],["XP_062835904.1","XP_003224422.2",0.977],["XP_062835904.1","XP_003226986.3",0.982],["XP_062816200.1","XP_008115209.2",0.977],["XP_062816200.1","XP_062816194.1",0.713],["XP_062816200.1","XP_062816205.1",0.834],["XP_062816200.1","XP_062818305.1",0.976],["XP_062816200.1","XP_062826299.1",0.985],["XP_062816200.1","XP_003221045.1",0.961],["XP_062816200.1","XP_003224422.2",0.986],["XP_062816200.1","XP_003226986.3",0.979],["XP_062816200.1","XP_008103467.1",0.658],["XP_062816205.1","XP_008115209.2",0.975],["XP_062816205.1","XP_062816194.1",0.86],["XP_062816205.1","XP_062818305.1",0.985],["XP_062816205.1","XP_062826299.1",0.978],["XP_062816205.1","XP_003221045.1",0.957],["XP_062816205.1","XP_003224422.2",0.976],["XP_062816205.1","XP_003226986.3",0.973],["XP_062816205.1","XP_008103467.1",0.712],["XP_008115209.2","XP_062816194.1",0.975],["XP_008115209.2","XP_062818305.1",0.912],["XP_008115209.2","XP_003221045.1",0.963],["XP_008115209.2","XP_003224422.2",0.966],["XP_008115209.2","XP_003226986.3",0.964],["XP_008115209.2","XP_008103467.1",0.912],["XP_062816194.1","XP_062818305.1",0.979],["XP_062816194.1","XP_062826299.1",0.96],["XP_062816194.1","XP_003221045.1",0.972],["XP_062816194.1","XP_003224422.2",0.986],["XP_062816194.1","XP_003226986.3",0.977],["XP_062816194.1","XP_008103467.1",0.772],["XP_003221045.1","XP_003226986.3",0.96],["XP_003221045.1","XP_003224422.2",0.651],["XP_003221045.1","XP_008103467.1",0.748],["XP_003221045.1","XP_062818305.1",0.983],["XP_003221045.1","XP_062826299.1",0.936],["XP_003226986.3","XP_003224422.2",0.99],["XP_003226986.3","XP_008103467.1",0.975],["XP_003226986.3","XP_062818305.1",0.977],["XP_003224422.2","XP_008103467.1",0.972],["XP_003224422.2","XP_062818305.1",0.974],["XP_003224422.2","XP_062826299.1",0.961],["XP_062826299.1","XP_008103467.1",0.963],["XP_062826299.1","XP_062818305.1",0.811],["XP_008103467.1","XP_062818305.1",0.984]],"all_go_terms":{"GO:0071028":2,"GO:0008033":2,"GO:0071038":3,"GO:0070481":2,"GO:0071042":3,"GO:0000964":2,"GO:0071039":2,"GO:0016120":2,"GO:0034473":2,"GO:0035928":2,"GO:0000958":2,"GO:0071051":3,"GO:2000627":2,"GO:0070651":2,"GO:0000962":2,"GO:0010323":2,"GO:0071035":3,"GO:0034476":3,"GO:0097222":2,"GO:0045006":2,"GO:0034475":3,"GO:0000467":3,"GO:0070478":2,"GO:0031054":1,"GO:0006351":1,"GO:0070934":2,"GO:1902219":1,"GO:0010587":1,"GO:0031564":1,"GO:0060567":1,"GO:1901724":1,"GO:0048026":10,"GO:0097010":9,"GO:0034462":9,"GO:0048025":9,"GO:1903608":2,"GO:1900363":9,"GO:0006446":9,"GO:0075525":9,"GO:0002188":9,"GO:0006396":1,"GO:0010610":9,"GO:0060211":9,"GO:0035278":9,"GO:0075522":9,"GO:0006376":9,"GO:0000380":9,"GO:0001731":9,"GO:0006378":9,"GO:1905663":9,"GO:1901407":9,"GO:0006406":9,"GO:0001825":9,"GO:0016556":9,"GO:0045292":9,"GO:0000381":9,"GO:1902625":9,"GO:0031047":10,"GO:0048255":9,"GO:1903586":9,"GO:0071230":5,"GO:0000289":1,"GO:1900365":5,"GO:0046011":5,"GO:0071456":5,"GO:0060213":6,"GO:0007310":5,"GO:0008069":5,"GO:0032869":5,"GO:1900248":5,"GO:0061158":5,"GO:0002931":5,"GO:0045451":6,"GO:0016554":1,"GO:0009228":1,"GO:0006479":1,"GO:0070476":1,"GO:0032775":1,"GO:0009452":1,"GO:0052837":1,"GO:0030488":1,"GO:0009229":1,"GO:0080180":1,"GO:0034227":1,"GO:0000245":1,"GO:0006999":1,"GO:0072417":1,"GO:0006607":1,"GO:0031990":1,"GO:0060188":1,"GO:0000244":1,"GO:1904570":1,"GO:0048701":1,"GO:0000390":1,"GO:1990416":1,"GO:0006605":1,"GO:0042273":1,"GO:0007317":1,"GO:0006260":1,"GO:0008306":1,"GO:0016457":1,"GO:1902626":1,"GO:0006268":1,"GO:0000398":1,"GO:0060303":1,"GO:0009432":1,"GO:0006269":1,"GO:0001178":1,"GO:0042255":1,"GO:0000462":1,"GO:0070870":1,"GO:0006369":1,"GO:0006306":1,"GO:0019079":1,"GO:0009949":1,"GO:0045944":1,"GO:0071894":1,"GO:0000378":1,"GO:0009047":1,"GO:0045433":1,"GO:0006311":1,"GO:1902775":1,"GO:0070417":1,"GO:0072715":1,"GO:0017038":1,"GO:0000463":1,"GO:0000350":1,"GO:0043044":1,"GO:0007076":1,"GO:0035640":1,"GO:0000466":1,"GO:0030423":1,"GO:0031453":1,"GO:0000349":1,"GO:0030720":1,"GO:0000716":1,"GO:0018144":1,"GO:0000335":1,"GO:0030717":1,"GO:0071441":1,"GO:1904574":1,"GO:1990120":1,"GO:0071049":1,"GO:0000464":1,"GO:0042766":1,"GO:0006283":1,"GO:0090669":1,"GO:0009951":1,"GO:0000393":1,"GO:0006363":1,"GO:0071031":1,"GO:0034247":1,"GO:0016584":1,"GO:0006301":1,"GO:0016441":1,"GO:0090394":1,"GO:1903241":1,"GO:0045003":1,"GO:0000388":1,"GO:0007294":1,"GO:2000623":1,"GO:1900050":1,"GO:0016973":1,"GO:0043629":1,"GO:0010501":1,"GO:2000616":1,"GO:0040022":1},"recipe_readded":[]}