{"hash":"74234997640396473","title":"Ubiquitin-Proteasome\u2013Mediated Cell Cycle Control","description":"The cluster is dominated by GO terms for ubiquitin-dependent proteolysis (SCF-dependent and general proteasomal degradation) and cell-cycle\u2013related processes (spindle assembly in meiosis, DNA replication initiation regulation, and G1 DNA damage checkpoint signaling). Microtubule polymerization and circadian rhythm regulation align with degradation-based control of cytoskeletal dynamics and timing, while stress responses to cadmium/arsenic reflect proteostasis-related signaling. Collectively, these terms point to coordinated protein turnover governing cell cycle progression and spindle function.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"XP_015634340.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_015651364.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025877586.1","go_terms":["GO:0031146"]},{"accession":"XP_066166594.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_015616318.1","go_terms":[]},{"accession":"XP_015611172.1","go_terms":[]}],"graph":[["XP_015651364.1","XP_066166594.1",0.832]],"all_go_terms":{"GO:0042752":3,"GO:0046785":3,"GO:0007057":3,"GO:0030174":3,"GO:0042787":3,"GO:0031146":4,"GO:0046685":3,"GO:0031571":3,"GO:0071276":3,"GO:1902916":3,"GO:0060386":3,"GO:0021678":3,"GO:0000083":3,"GO:0006516":3,"GO:1903378":3,"GO:0021993":3,"GO:0051436":3,"GO:0001556":3,"GO:0071406":3,"GO:0070544":3,"GO:0008285":3,"GO:0000209":3},"recipe_readded":["XP_066160634.1","XP_066165550.1","XP_015616746.2","XP_066164412.1","XP_015648305.1","XP_015648829.1","XP_015613089.2","XP_015645664.1","XP_015650494.1","XP_066161207.1","XP_066163906.1","XP_015618032.1","XP_066165490.1","XP_015616708.1","XP_025876665.2","XP_015637483.1","XP_015611040.1","NP_001411525.1","XP_025883301.1","XP_015632993.1"]}