{"hash":"293981382246592406","title":"Folate-one-carbon metabolism and thymidylate biosynthesis","description":"The top GO terms cluster around folate metabolism and one-carbon chemistry (tetrahydrofolate interconversion, folic acid metabolism) and serine biosynthesis/catabolism, feeding into dTMP biosynthesis. This suggests proteins function mainly in supplying one-carbon units for nucleotide synthesis, with some secondary signals related to translation regulation and interferon response. Overall, the core theme is folate/one-carbon metabolism linked to thymidylate production.","confidence":"High","size":9,"edges":23,"triangles":31,"max_degree":7,"top_function":null,"members":[{"accession":"XP_066166731.1","go_terms":["GO:1904482","GO:0034340","GO:0035999","GO:0009113","GO:0046655","GO:0006565","GO:0006564","GO:0006231","GO:0051289","GO:0019264","GO:0017148","GO:0032259"]},{"accession":"XP_015639130.1","go_terms":[]},{"accession":"XP_015626192.1","go_terms":["GO:0017148","GO:0006412","GO:0000027"]},{"accession":"XP_015625272.1","go_terms":["GO:0006412"]},{"accession":"NP_001364863.1","go_terms":[]},{"accession":"XP_025878279.1","go_terms":["GO:0007033","GO:0006878","GO:0015991","GO:0006626","GO:0007035","GO:0006623","GO:0042777","GO:0006814"]},{"accession":"NP_001388950.1","go_terms":["GO:0009157","GO:0016310","GO:0046104","GO:0071897"]},{"accession":"XP_015631534.1","go_terms":[]},{"accession":"XP_015637097.1","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]}],"graph":[["XP_015639130.1","XP_015625272.1",0.756],["XP_015639130.1","XP_015626192.1",0.976],["XP_015639130.1","XP_015631534.1",0.651],["XP_015639130.1","XP_015637097.1",0.859],["XP_015639130.1","XP_025878279.1",0.718],["XP_015639130.1","NP_001364863.1",0.763],["XP_015637097.1","XP_015625272.1",0.588],["XP_015637097.1","XP_015626192.1",0.943],["XP_015637097.1","XP_015631534.1",0.795],["XP_015626192.1","XP_015625272.1",0.949],["XP_015626192.1","XP_015631534.1",0.977],["XP_015626192.1","XP_025878279.1",0.87],["XP_015626192.1","NP_001364863.1",0.918],["XP_015626192.1","NP_001388950.1",0.967],["XP_025878279.1","XP_015631534.1",0.717],["XP_025878279.1","NP_001364863.1",0.885],["XP_025878279.1","NP_001388950.1",0.921],["XP_015625272.1","XP_015631534.1",0.967],["XP_015625272.1","NP_001364863.1",0.728],["XP_015625272.1","NP_001388950.1",0.872],["XP_015631534.1","NP_001364863.1",0.97],["XP_015631534.1","NP_001388950.1",0.828],["NP_001388950.1","NP_001364863.1",0.918]],"all_go_terms":{"GO:1904482":1,"GO:0051289":1,"GO:0006564":1,"GO:0006231":1,"GO:0046655":1,"GO:0034340":1,"GO:0006565":1,"GO:0035999":1,"GO:0032259":1,"GO:0009113":1,"GO:0017148":2,"GO:0019264":1,"GO:0006412":2,"GO:0000027":1,"GO:0006626":1,"GO:0007035":1,"GO:0006623":1,"GO:0015991":1,"GO:0006814":1,"GO:0042777":1,"GO:0006878":1,"GO:0007033":1,"GO:0071897":1,"GO:0046104":1,"GO:0016310":1,"GO:0009157":1,"GO:0016556":1,"GO:0048255":1,"GO:0075522":1,"GO:1905663":1,"GO:0006378":1,"GO:0097010":1,"GO:0000380":1,"GO:0001825":1,"GO:1903586":1,"GO:0045292":1,"GO:0006406":1,"GO:0001731":1,"GO:0048025":1,"GO:1901407":1,"GO:0034462":1,"GO:0006376":1,"GO:0075525":1,"GO:1902625":1,"GO:0000381":1,"GO:0035278":1,"GO:0002188":1,"GO:0060211":1,"GO:0010610":1,"GO:0006446":1,"GO:0048026":1,"GO:1900363":1,"GO:0031047":1},"recipe_readded":[]}