{"hash":"2137768097207183364","title":"Immune Response Regulation","description":"The cluster\u2019s GO terms cluster around immune signaling and regulation: negative regulation of IL-1\u03b2 and IL-2 production, regulation of CD40 signaling, germinal center formation, and mucosal immune response, plus a response to muramyl dipeptide, all pointing to regulatory roles in both innate and adaptive immunity. The presence of K63-linked deubiquitination supports regulatory control of signaling pathways rather than core effector functions. These together suggest a cohesive theme of modulating immune activation and signaling. ","confidence":"High","size":18,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"members":[{"accession":"XP_015645273.1","go_terms":["GO:0006412"]},{"accession":"XP_025883135.1","go_terms":["GO:0048745","GO:0006616","GO:0071243","GO:0060324","GO:0003016","GO:0071218","GO:0010761","GO:1902042","GO:0050869","GO:0060368","GO:2000349","GO:0071108","GO:0071947","GO:0048008","GO:0032495","GO:2000347","GO:0070936","GO:0002385","GO:0002686","GO:0048261","GO:0002677","GO:0070433","GO:0001944","GO:0043305","GO:0035871","GO:0032703","GO:0043124","GO:0031397","GO:0032720","GO:0070536","GO:0035214","GO:0048662","GO:0070301","GO:2000352","GO:0001922","GO:0002634","GO:0034140","GO:0034148","GO:0072573","GO:0070429","GO:1900165","GO:0032691","GO:1900235","GO:0032717","GO:0045736"]},{"accession":"XP_015634221.1","go_terms":[]},{"accession":"XP_015624989.1","go_terms":[]},{"accession":"XP_015630239.1","go_terms":["GO:1901599"]},{"accession":"XP_015635914.1","go_terms":[]},{"accession":"XP_015629007.1","go_terms":[]},{"accession":"XP_015629009.1","go_terms":[]},{"accession":"XP_066160564.1","go_terms":[]},{"accession":"XP_015643329.1","go_terms":["GO:0051384","GO:0042136","GO:0046340","GO:0050783","GO:0007612","GO:0030245","GO:0050808","GO:0060041","GO:0001507","GO:0090122","GO:0019441","GO:0014016","GO:0048444","GO:0051262","GO:0051791","GO:0008285","GO:0045212","GO:0043279","GO:0032223","GO:0031623","GO:0009740","GO:0051593","GO:0019695","GO:0042493","GO:0010325","GO:0006695","GO:0009939","GO:0001919","GO:0002076","GO:0015705","GO:2000463","GO:0097091","GO:0061002","GO:2000809","GO:0010841","GO:0002087","GO:0097104","GO:0042982","GO:0098942","GO:2000310","GO:0048789","GO:1900244","GO:0016042","GO:1902474","GO:2000331","GO:1904862","GO:1904861","GO:2000969","GO:0097105","GO:0097151","GO:0090394","GO:0072553","GO:2000302","GO:0097115","GO:0097116","GO:0051968","GO:0097119","GO:0007158"]},{"accession":"XP_015622550.1","go_terms":["GO:0006071","GO:0034478","GO:0030643","GO:0010442"]},{"accession":"XP_015627251.1","go_terms":[]},{"accession":"XP_015646059.1","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_001408805.1","go_terms":["GO:0042219"]},{"accession":"NP_001410158.1","go_terms":[]},{"accession":"NP_001404609.1","go_terms":["GO:0052324","GO:0010215","GO:0016049","GO:0048765"]},{"accession":"NP_001411135.1","go_terms":["GO:0010951"]},{"accession":"XP_066167849.1","go_terms":[]}],"graph":[["XP_015643329.1","XP_015635914.1",0.574],["XP_015627251.1","XP_015635914.1",0.644],["XP_015622550.1","XP_015635914.1",0.925],["XP_015630239.1","XP_015635914.1",0.803],["XP_015645273.1","XP_015635914.1",0.79],["XP_015635914.1","XP_015629009.1",0.52],["XP_015635914.1","NP_001408805.1",0.875]],"all_go_terms":{"GO:0006412":1,"GO:0032691":1,"GO:0002634":1,"GO:0032495":1,"GO:0002385":1,"GO:0048008":1,"GO:0071243":1,"GO:2000349":1,"GO:0032703":1,"GO:0070536":1,"GO:0001944":1,"GO:0070429":1,"GO:0035214":1,"GO:0043305":1,"GO:0002677":1,"GO:0001922":1,"GO:1900165":1,"GO:2000352":1,"GO:0034140":1,"GO:0035871":1,"GO:0048261":1,"GO:0072573":1,"GO:0048745":1,"GO:0060324":1,"GO:0070936":1,"GO:0071218":1,"GO:0071947":1,"GO:0070433":1,"GO:0032717":1,"GO:0050869":1,"GO:0043124":1,"GO:0048662":1,"GO:0010761":1,"GO:0031397":1,"GO:0032720":1,"GO:0070301":1,"GO:2000347":1,"GO:0002686":1,"GO:0006616":1,"GO:0045736":1,"GO:0034148":1,"GO:0003016":1,"GO:1902042":1,"GO:1900235":1,"GO:0071108":1,"GO:0060368":1,"GO:1901599":1,"GO:1904862":1,"GO:0050808":1,"GO:0097115":1,"GO:1904861":1,"GO:0097151":1,"GO:0048789":1,"GO:0030245":1,"GO:1902474":1,"GO:0007612":1,"GO:0032223":1,"GO:0050783":1,"GO:0006695":1,"GO:0002087":1,"GO:0014016":1,"GO:0051593":1,"GO:0097105":1,"GO:0072553":1,"GO:0097104":1,"GO:1900244":1,"GO:0051384":1,"GO:0042493":1,"GO:0010325":1,"GO:2000310":1,"GO:0051968":1,"GO:2000463":1,"GO:0090394":1,"GO:0007158":1,"GO:0061002":1,"GO:0016042":1,"GO:0009939":1,"GO:0097119":1,"GO:2000809":1,"GO:0002076":1,"GO:0010841":1,"GO:0015705":1,"GO:2000302":1,"GO:0019695":1,"GO:0042982":1,"GO:0046340":1,"GO:2000331":1,"GO:0097116":1,"GO:0098942":1,"GO:0090122":1,"GO:0043279":1,"GO:0048444":1,"GO:0051262":1,"GO:0031623":1,"GO:0019441":1,"GO:0097091":1,"GO:2000969":1,"GO:0060041":1,"GO:0051791":1,"GO:0008285":1,"GO:0042136":1,"GO:0001919":1,"GO:0001507":1,"GO:0009740":1,"GO:0045212":1,"GO:0006071":1,"GO:0010442":1,"GO:0034478":1,"GO:0030643":1,"GO:0010265":1,"GO:0000086":1,"GO:0051457":1,"GO:0010458":1,"GO:0042787":1,"GO:0031146":1,"GO:0000226":1,"GO:0046686":1,"GO:0000921":1,"GO:0045910":1,"GO:0016032":1,"GO:0060542":1,"GO:0035518":1,"GO:2000766":1,"GO:0009873":1,"GO:0007035":1,"GO:0007059":1,"GO:0007275":1,"GO:0009734":1,"GO:0070911":1,"GO:0042219":1,"GO:0010215":1,"GO:0052324":1,"GO:0016049":1,"GO:0048765":1,"GO:0010951":1},"recipe_readded":["XP_015611845.1","XP_015638388.2","XP_066159707.1","XP_015617566.1","NP_001411518.1","XP_066159392.1","XP_015647916.1","XP_015650683.1","XP_025881062.1","XP_015632420.1","XP_066165024.1","XP_015616067.1","XP_066159393.1","XP_015646563.1","XP_015648977.1","XP_025879730.2","XP_015624058.1","XP_015633275.1","XP_015643512.1","XP_066166638.1"]}