{"hash":"560700581731426197","title":"N-terminal acetylation and related PTMs","description":"The top GO terms are dominated by N-terminal acetylation-related activities (peptidyl-glutamic acid acetylation, peptidyl-methionine acetylation, peptidyl-lysine N6-acetylation, and N-terminal propionylation), suggesting enzymes that transfer acetyl groups to protein N-termini or adjacent substrates. Additional terms point to acetyl-transfer\u2013driven biosynthetic pathways (mycothiol, ectoine) and other acetylation-associated metabolism (e.g., arginine biosynthesis, acetoin catabolism). Together these indicate a cohesive group of N-acetyltransferases and related modifications, with some breadth into small-molecule acetyl biosynthesis; hence the label reflects the cluster\u2019s shared theme more than individual pathways.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"members":[{"accession":"XP_004930199.1","go_terms":["GO:0001701","GO:0001302","GO:0010064","GO:0018008","GO:0032920","GO:0019491","GO:0010125","GO:0046208","GO:0001525","GO:0071962","GO:0006348","GO:0006526","GO:0017196","GO:0061606","GO:0017198","GO:0030187","GO:0032919","GO:0032918","GO:0043967","GO:0060358","GO:0009447","GO:0045150","GO:0006041","GO:0006044","GO:2000025","GO:0018003","GO:0018002"]},{"accession":"XP_004931540.1","go_terms":["GO:0030435","GO:0006474","GO:0032920","GO:0019491","GO:0010125","GO:0046208","GO:0001525","GO:0071962","GO:0006348","GO:0006526","GO:0017196","GO:0061606","GO:0017198","GO:0030187","GO:0032919","GO:0032918","GO:0043967","GO:0060358","GO:0009447","GO:0045150","GO:0006041","GO:0006044","GO:2000025","GO:0018003","GO:0018002"]},{"accession":"NP_001040325.1","go_terms":["GO:0030435","GO:0006474","GO:0032920","GO:0019491","GO:0010125","GO:0046208","GO:0001525","GO:0071962","GO:0006348","GO:0006526","GO:0017196","GO:0061606","GO:0017198","GO:0030187","GO:0032919","GO:0032918","GO:0043967","GO:0060358","GO:0009447","GO:0045150","GO:0006041","GO:0006044","GO:2000025","GO:0018003","GO:0018002"]},{"accession":"XP_004931559.1","go_terms":["GO:0032920","GO:0019491","GO:0010125","GO:0046208","GO:0001525","GO:0071962","GO:0006348","GO:0006526","GO:0017196","GO:0061606","GO:0017198","GO:0030187","GO:0032919","GO:0032918","GO:0043967","GO:0060358","GO:0009447","GO:0045150","GO:0006041","GO:0006044","GO:2000025","GO:0018003","GO:0018002"]},{"accession":"XP_012544364.1","go_terms":["GO:0030435","GO:0006474","GO:0009553","GO:1990523","GO:0034087","GO:0070058","GO:2000720","GO:0034089","GO:0018003","GO:0071168","GO:0006275","GO:0060772","GO:0002244","GO:0034421","GO:0007076","GO:0080186","GO:0048653","GO:0007062","GO:0032920","GO:0019491","GO:0010125","GO:0046208","GO:0001525","GO:0071962","GO:0006348","GO:0006526","GO:0017196","GO:0061606","GO:0017198","GO:0030187","GO:0032919","GO:0032918","GO:0043967","GO:0060358","GO:0009447","GO:0045150","GO:0006041","GO:0006044","GO:2000025","GO:0018002"]},{"accession":"XP_012544366.1","go_terms":["GO:0030435","GO:0006474","GO:0032920","GO:0019491","GO:0010125","GO:0046208","GO:0001525","GO:0071962","GO:0006348","GO:0006526","GO:0017196","GO:0061606","GO:0017198","GO:0030187","GO:0032919","GO:0032918","GO:0043967","GO:0060358","GO:0009447","GO:0045150","GO:0006041","GO:0006044","GO:2000025","GO:0018003","GO:0018002"]}],"graph":[["XP_012544366.1","NP_001040325.1",0.853],["XP_012544366.1","XP_004930199.1",0.963],["XP_012544366.1","XP_004931540.1",0.961],["XP_012544366.1","XP_004931559.1",0.962],["XP_012544366.1","XP_012544364.1",0.961],["XP_004931540.1","NP_001040325.1",0.961],["XP_004931540.1","XP_004930199.1",0.963],["XP_004931540.1","XP_004931559.1",0.962],["XP_004931540.1","XP_012544364.1",0.961],["NP_001040325.1","XP_004930199.1",0.963],["NP_001040325.1","XP_004931559.1",0.962],["NP_001040325.1","XP_012544364.1",0.961],["XP_004930199.1","XP_004931559.1",0.963],["XP_004930199.1","XP_012544364.1",0.963],["XP_012544364.1","XP_004931559.1",0.962]],"all_go_terms":{"GO:0006526":6,"GO:0061606":6,"GO:0045150":6,"GO:0018002":6,"GO:0018008":1,"GO:0046208":6,"GO:0001701":1,"GO:0019491":6,"GO:0017196":6,"GO:0060358":6,"GO:0018003":6,"GO:0010125":6,"GO:2000025":6,"GO:0006041":6,"GO:0032918":6,"GO:0032919":6,"GO:0006044":6,"GO:0001525":6,"GO:0017198":6,"GO:0043967":6,"GO:0010064":1,"GO:0032920":6,"GO:0071962":6,"GO:0006348":6,"GO:0030187":6,"GO:0009447":6,"GO:0001302":1,"GO:0030435":4,"GO:0006474":4,"GO:0009553":1,"GO:0034421":1,"GO:0007076":1,"GO:0071168":1,"GO:0006275":1,"GO:1990523":1,"GO:0007062":1,"GO:0060772":1,"GO:0080186":1,"GO:0070058":1,"GO:2000720":1,"GO:0034089":1,"GO:0034087":1,"GO:0048653":1,"GO:0002244":1},"recipe_readded":[]}