{"hash":"2019684398465283736","title":"Negative regulation of innate immune signaling","description":"Most terms describe downregulation or suppression of immune signaling pathways (negative regulation of IL-8, NOD2, TLR3, CD40 signaling; tolerance to LPS; B cell homeostasis). Deubiquitination terms (K33/K63-linked) are regulatory mechanisms for these pathways, supporting the theme of dampening inflammation. A single term on larval cuticle development appears incidental noise rather than a defining function of the cluster.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"members":[{"accession":"NP_001166655.1","go_terms":["GO:0008363"]},{"accession":"NP_001166671.1","go_terms":["GO:0008363"]},{"accession":"XP_021206612.1","go_terms":["GO:1902042","GO:2000347","GO:2000349","GO:0071108","GO:0071947","GO:1990167","GO:0032495","GO:1990168","GO:0002385","GO:0002677","GO:0070433","GO:0035871","GO:0032691","GO:0043124","GO:0070536","GO:0032703","GO:2000352","GO:0001922","GO:0002634","GO:0034140","GO:0035523","GO:0034148","GO:0072573","GO:0044313","GO:0070429","GO:0032717","GO:0016567"]},{"accession":"XP_004929711.1","go_terms":[]}],"graph":[["NP_001166671.1","NP_001166655.1",0.857],["NP_001166671.1","XP_004929711.1",0.518],["NP_001166671.1","XP_021206612.1",0.593],["XP_021206612.1","NP_001166655.1",0.705],["XP_021206612.1","XP_004929711.1",0.64]],"all_go_terms":{"GO:0008363":2,"GO:1990168":1,"GO:0002677":1,"GO:0070536":1,"GO:0032717":1,"GO:0070433":1,"GO:2000349":1,"GO:0072573":1,"GO:0001922":1,"GO:0034140":1,"GO:0002634":1,"GO:2000352":1,"GO:0034148":1,"GO:0016567":1,"GO:1990167":1,"GO:0044313":1,"GO:0035871":1,"GO:0070429":1,"GO:0032691":1,"GO:0032495":1,"GO:0032703":1,"GO:0071108":1,"GO:2000347":1,"GO:0071947":1,"GO:1902042":1,"GO:0035523":1,"GO:0002385":1,"GO:0043124":1},"recipe_readded":[]}