[{"hash":"1652473132819264709","title":"RNA processing and ribosome biogenesis","description":"The cluster is enriched for mRNA export, splicing regulation, and translation/preinitiation complex formation, plus ribosomal subunit biogenesis; together they mark RNA metabolism and assembly of the translation machinery.","confidence":"High","size":29,"edges":44,"triangles":19,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":8},{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0019079","count":4},{"id":"GO:0006260","count":4}]},{"hash":"736285238344573503","title":"RNA processing and translation regulation","description":"This cluster centers on mRNA processing and translation control, with strong representation of translation initiation and preinitiation complex formation, plus IRES-dependent initiation and regulation of translational initiation. It also includes splicing-related terms (spliceosome-mediated splicing, splice site recognition) and mRNA stability regulation under stress, suggesting roles in RNA maturation and turnover. Overall, the proteins likely participate in RNA metabolism bridging RNA processing and translational control.","confidence":"High","size":29,"edges":131,"triangles":373,"max_degree":20,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0075522","count":10},{"id":"GO:0006446","count":10},{"id":"GO:0006378","count":10}]},{"hash":"823645883869362516","title":"RNA processing and translational regulation","description":"The dominant GO terms cluster around translation initiation (preinitiation complex, IRES-dependent initiation) and mRNA splicing/regulation, with stress response and development hints, suggesting a module of post-transcriptional gene expression control linking RNA processing to translation.","confidence":"Medium","size":29,"edges":23,"triangles":4,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0075522","count":6},{"id":"GO:0006446","count":6},{"id":"GO:1901407","count":6}]},{"hash":"518037336527348293","title":"Retinoid metabolism and retinoic acid signaling","description":"The top GO terms are strongly centered on retinol and retinal metabolic processes and regulation of the retinoic acid receptor signaling pathway, indicating a cohesive set of proteins involved in vitamin A\u2013derived retinoid metabolism and its signaling. While there are additional terms related to stress responses, the dominant signal points to a retinoid-related functional theme.","confidence":"High","size":29,"edges":352,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":26},{"id":"GO:0042574","count":26},{"id":"GO:0009414","count":15},{"id":"GO:0097238","count":14},{"id":"GO:0016488","count":14}]},{"hash":"868990468660083232","title":"Developmental morphogenesis and cytoskeletal regulation","description":"The proteins show clear links to developmental processes (larval cuticle development, multicellular development, cerebellum morphogenesis) and to cytoskeletal dynamics (actin organization, ruffle assembly), with regulatory signals including GTPase activity modulation and JNK pathway regulation, suggesting a cohesive role in tissue morphogenesis through cytoskeletal remodeling.","confidence":"Medium","size":29,"edges":39,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":8},{"id":"GO:0007275","count":3},{"id":"GO:0046328","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0035278","count":2}]},{"hash":"810158274732364280","title":"Neuronal projection and dendrite morphogenesis","description":"Top GO terms are dominated by neuronal development and dendrite morphogenesis (dendrite morphogenesis, neuron projection development, CNS neuron development), with additional signals for microtubule dynamics (positive regulation of microtubule polymerization). This points to a cluster of proteins involved in shaping neuronal processes and their cytoskeleton. Some terms like megakaryocyte development and neurofibrillary tangle assembly hint at cytoskeletal/neurodegenerative context but do not contradict the neuronal/cytoskeletal theme.","confidence":"High","size":29,"edges":12,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048813","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0035855","count":3},{"id":"GO:0000122","count":3},{"id":"GO:1902988","count":3}]},{"hash":"1309143778170340529","title":"Glycosylation and Fucosylation in Immune Cell Trafficking","description":"The top GO terms point to glycosylation and fucosylation (including Lewis A biosynthesis and N-glycan fucosylation) and immune-related processes (leukocyte migration and regulatory T cell differentiation), suggesting a theme of glycan modifications shaping immune cell interactions and movement. Some neuronal migration and metabolic terms appear but are less central to the core pattern. ","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":5},{"id":"GO:0042355","count":4},{"id":"GO:0036071","count":4},{"id":"GO:0097150","count":4},{"id":"GO:0010493","count":4}]},{"hash":"1022102941790385139","title":"Epigenetic Regulation and Immune Signaling","description":"The top terms show transcriptional regulation by RNA polymerase II (both positive and negative regulation) together with multiple epigenetic modifications (histone methylation, DNA methylation, histone deacetylation), plus RNA modification processes and signaling (lipopolysaccharide response and Wnt). This pattern indicates a cluster focused on controlling gene expression through chromatin state and epigenetic mechanisms, with an immune signaling component. ","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":7},{"id":"GO:0032496","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0016055","count":5},{"id":"GO:0031167","count":4}]},{"hash":"548763583930869325","title":"NF-kappaB\u2013driven antiviral signaling and proteasome activity","description":"These proteins cluster around antiviral immune signaling and proteasome-mediated protein turnover: NF-kappaB pathway activation, defense against viruses, and ubiquitin-proteasome degradation. B cell homeostasis adds an immune context. Some terms are obsolete or broad, but the core theme is immune signaling linked to proteostasis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032508","count":3},{"id":"GO:0071479","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0001782","count":2},{"id":"GO:0051092","count":2}]},{"hash":"507495964310672906","title":"Ubiquitin-Mediated Proteolysis and Immune Signaling","description":"These proteins are strongly enriched for ubiquitin-related processes: ubiquitin-dependent protein catabolic process, autoubiquitination, multiple ubiquitin linkages (K63, K6, K11) and ERAD, plus enrichment for innate immune response and NF-kappaB-related regulation. This points to a cohesive module where ubiquitin-mediated protein turnover interfaces with immune signaling pathways.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0030433","count":7},{"id":"GO:0051301","count":6},{"id":"GO:0070534","count":6}]},{"hash":"1207037132251146271","title":"Embryonic development and organogenesis","description":"This cluster\u2019s top GO terms center on developmental processes across multiple tissues\u2014left-right patterning, placenta and trophoblast differentiation, endocrine development, endocardial EMT, cartilage morphogenesis, and pancreatic development\u2014pointing to a broad theme of developmental differentiation and organogenesis. Some terms (splicing, symbiont entry) are less directly connected, but the overall signal supports a developmental/morphogenesis focus.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0046718","count":5},{"id":"GO:0003323","count":4},{"id":"GO:1903026","count":4},{"id":"GO:0003198","count":4}]},{"hash":"30425803152179810","title":"Embryonic Development and Tissue Morphogenesis","description":"These proteins show strong enrichment for GO terms tied to embryonic development and tissue/organ morphogenesis, including mesoderm development, cartilage morphogenesis, pancreas cell development, endocardial cushion EMT, trophoblast differentiation, endocrine system development, and left-right pattern formation. Together these point to a cohesive theme of embryonic development and organ/tissue formation, with ancillary processes like mRNA splicing not altering the overall developmental signal.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060536","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0060707","count":8}]},{"hash":"1713268271647163346","title":"Neural development and signaling","description":"The top GO terms point strongly to nervous system development, sensory perception (including visual perception and pain), and ion-mediated signaling (calcium-dependent exocytosis, potassium ion transport). Together with transcriptional regulatory processes, these imply proteins involved in neuronal differentiation and communication. Some terms like glucose response and dsRNA response are present but do not define the core theme; the clustering is best described by neural development and signaling functions.","confidence":"High","size":29,"edges":159,"triangles":300,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071333","count":18},{"id":"GO:0043330","count":18},{"id":"GO:0046827","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0006351","count":14}]},{"hash":"1996048412286697288","title":"Organogenesis and embryonic development","description":"This cluster is dominated by GO terms tied to development across multiple organs (pituitary, retina/eye, heart, hindlimb, osteoblasts, prostate), plus embryonic morphogenesis and regulation of transcription, indicating a broad developmental/programmatic role rather than a single tissue-specific function.","confidence":"High","size":29,"edges":84,"triangles":39,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":13},{"id":"GO:0000122","count":12},{"id":"GO:0060041","count":12},{"id":"GO:0002076","count":12},{"id":"GO:0002087","count":12}]},{"hash":"1017676172874954243","title":"Unknown","description":"The top terms span multiple, unrelated processes: Notch signaling; iron transport and homeostasis (iron import, transferrin transport); endocytosis and vacuolar protein catabolism; plant development (inflorescence meristem growth); and miscellaneous metabolic processes. The lack of a single cohesive function or pathway dominating the cluster suggests no tight shared biological role, so a concise, unified label isn\u2019t appropriate.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":2},{"id":"GO:0017186","count":1},{"id":"GO:0007039","count":1},{"id":"GO:0006898","count":1},{"id":"GO:0006879","count":1}]},{"hash":"1826838379134698284","title":"Developmental Regulation and Innate Immunity","description":"The cluster\u2019s top GO terms point to developmental programs (midbrain development, multicellular organism growth, tissue remodeling, endothelial barrier establishment) alongside innate immune and coagulation-related activities (neutrophil-mediated killing, defense against Gram-positive bacteria, Factor XII activation). This suggests a module coordinating development with vascular/immune remodeling rather than a single narrow function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0030901","count":14},{"id":"GO:0045944","count":13},{"id":"GO:0050830","count":13},{"id":"GO:1903142","count":12}]},{"hash":"1364059974819171959","title":"Chromatin and RNA Processing Linked to Cell Cycle","description":"The dominant terms indicate processes that govern gene expression and genome management (chromatin organization, rRNA maturation, mRNA transport, translation reinitiation) in the context of cell division and growth (cell cycle checkpoint regulation, meiotic division, organism growth, proliferation). Although a few terms (defense response to Gram-positive bacterium; fungal-type cell wall biogenesis) seem less connected, the core theme centers on chromatin-level control of expression and progression through the cell cycle.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0050830","count":8},{"id":"GO:0031497","count":7},{"id":"GO:0051028","count":7},{"id":"GO:0000463","count":7},{"id":"GO:1901976","count":7}]},{"hash":"997125342280023167","title":"Developmental signaling and transcription regulation","description":"The terms are dominated by transcriptional regulation (positive and negative) and Wnt signaling, pointing to a core theme of developmental signaling and transcription control. Additional terms like biomineral tissue development, endothelial barrier establishment, and other physiological processes suggest roles in tissue differentiation and vascular-immune contexts, though some terms appear more peripheral to the central theme. Overall, a label focusing on developmental signaling and transcriptional regulation best captures the cluster's shared function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0016055","count":5},{"id":"GO:0045944","count":4},{"id":"GO:0031214","count":4},{"id":"GO:0007586","count":4}]},{"hash":"637616656751167669","title":"Immune development and signaling","description":"The cluster features GO terms tied to immune system development and activation (innate immune response, thymus development, NK T cell differentiation, IL-4 production) and signaling/regulation (JUN phosphorylation, Wnt signaling). These point to processes governing immune cell maturation and transcriptional control, with some terms like neuron development and protein export regulation likely reflecting broader developmental networks or annotation overlap. Therefore, naming it immune development and signaling best captures the main function represented.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0048666","count":4},{"id":"GO:0007258","count":4},{"id":"GO:0006351","count":3}]},{"hash":"1109312224403332581","title":"Cerebellar synaptic development and learning","description":"Top GO terms cluster around neural signaling and plasticity, including long-term synaptic depression, receptor clustering, and cerebellar granule cell differentiation, plus learning-related processes such as olfactory learning and sensory perception of sound. This points to a cerebellar-centered role in synapse development and learning.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0035023","count":3}]},{"hash":"1947086562321769042","title":"Vesicle trafficking and fusion regulation","description":"The top GO terms cluster around processes that control membrane trafficking and vesicle fusion, including synaptic vesicle priming and maturation, intracellular transport, and exocytosis-related events like acrosome reaction and neutrophil degranulation. They also encompass regulatory signaling that modulates cytoskeletal dynamics (Rho/Ras), which underpins vesicle trafficking and membrane fusion across diverse contexts such as myoblast fusion and symbiont entry into host cells. This points to a cohesive theme of regulated vesicle trafficking and membrane fusion across cell types.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0046580","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0016082","count":3},{"id":"GO:0043314","count":3}]},{"hash":"1005639574895008870","title":"RNA processing and ribosome biogenesis","description":"This cluster centers on RNA metabolism: mRNA splicing via spliceosome, RNA-protein cross-linking, nuclear polyadenylation-dependent mRNA decay, ribosome assembly, and rRNA maturation. Together these suggest a core role in RNA processing and ribosome biogenesis. A few terms (DNA replication, embryonic cranial skeleton morphogenesis) are less connected, possibly reflecting pleiotropic or incidental associations.","confidence":"High","size":28,"edges":39,"triangles":45,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":10},{"id":"GO:0048701","count":10},{"id":"GO:0048026","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0031047","count":8}]},{"hash":"918295165918640451","title":"Eggshell formation and gamete interaction","description":"This cluster is most strongly defined by terms related to reproductive biology, notably chorion-containing eggshell formation and regulation of the acrosome reaction, which together imply gamete development and interaction; other terms are more general physiological responses but do not override the reproductive signal.","confidence":"Medium","size":28,"edges":56,"triangles":73,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0007304","count":3},{"id":"GO:0007155","count":2},{"id":"GO:0060046","count":2},{"id":"GO:0002724","count":2}]},{"hash":"369978118471858015","title":"Retroviral integration and latency","description":"The top terms cluster around entry into the host cell or nucleus, reverse transcription (RNA-templated DNA biosynthesis), DNA replication and recombination, DNA integration, and establishment of proviral latency, all hallmarks of the retroviral life cycle, plus a note on suppression of host RNA silencing. This combination strongly suggests proteins involved in retroviral replication and integration, and in manipulating host processes to maintain latency. ","confidence":"High","size":28,"edges":257,"triangles":1366,"max_degree":25,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":19},{"id":"GO:0006260","count":18},{"id":"GO:0075732","count":16},{"id":"GO:0046718","count":16},{"id":"GO:1903704","count":16}]},{"hash":"1991332611678405480","title":"RNA Processing and Ribosome Biogenesis","description":"The cluster is dominated by RNA processing and ribosome-related terms: mRNA splicing, rRNA maturation, ribosome biogenesis, and translation initiation/translation reinitiation, suggesting a shared role in RNA processing and ribosome assembly/translation. Some peripheral terms (antibiotic response, transcription regulation, proteasomal degradation) are present but do not outweigh the core ribosome/translation theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0042273","count":4}]},{"hash":"76660574750739933","title":"Biosynthesis of vitamins and lipids; xenobiotic response","description":"The cluster\u2019s frequent GO terms center on biosynthetic pathways for vitamins and lipids (biotin, menaquinone, sterols, antibiotic biosynthesis, PHB), suggesting a core theme of small-molecule production. The presence of cellular/xenobiotic response terms (response to toxic substance, cellular response to xenobiotic stimulus) alongside proteolysis hints at a secondary association with detox or stress responses, but the dominant signal is biosynthesis.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0009234","count":7},{"id":"GO:0009102","count":7},{"id":"GO:0055114","count":7},{"id":"GO:0009636","count":6}]},{"hash":"912109202406320246","title":"Viral integration and proviral latency","description":"The top terms strongly point to viral genome integration into host DNA, reverse transcription (RNA-templated DNA synthesis), and establishment of proviral latency, with related host chromatin localization and cell-entry processes. These features together define a cluster centered on viral genome integration and maintenance of latency, with associated host interactions.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0039651","count":3}]},{"hash":"1865932882200887951","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning complement activation (lectin and classical pathways), various signaling pathways (Wnt, PKC), integrin regulation, platelet activation, and several neural/developmental/behavior terms (Purkinje cell development, vocalization, fertilization). There is no single cohesive theme tying these functions together, so a precise, representative label cannot be confidently assigned.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0006958","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0006924","count":2},{"id":"GO:0033623","count":2}]},{"hash":"2109628706022080983","title":"T Cell Activation and Cytoskeletal Remodeling","description":"This cluster shows strong signals for adaptive immune processes (adaptive immune response, T cell receptor signaling, interleukin-2 production) together with cytoskeletal dynamics (actin filament organization, lamellipodium assembly, cell spreading). The co-occurrence suggests proteins that drive T cell activation and immunological synapse formation, which require coordinated signaling and actin remodeling. The presence of innate immune terms may reflect shared pathways but the dominant theme is T cell signaling linked to cytoskeletal changes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0002250","count":4},{"id":"GO:1900042","count":3},{"id":"GO:0007015","count":3}]},{"hash":"354078987493537937","title":"RNA processing and ribosome biogenesis","description":"The GO terms cluster around core RNA metabolism: mRNA splicing via the spliceosome, splice-site recognition, poly(A) tail regulation, mRNA stabilization, translation initiation and reinitiation, and small-subunit processome assembly, all pointing to RNA processing and ribosome biogenesis/translation control. The larval cuticle development term appears as a secondary association rather than the primary theme, suggesting annotation noise or broader developmental expression, but the dominant signal is RNA processing and translation machinery. ","confidence":"Medium","size":27,"edges":329,"triangles":2424,"max_degree":26,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0008363","count":14},{"id":"GO:0048026","count":4},{"id":"GO:0075522","count":4},{"id":"GO:0006376","count":4},{"id":"GO:0060211","count":4}]},{"hash":"458518112335985765","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":315,"triangles":2224,"max_degree":26,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008363","count":19},{"id":"GO:0030433","count":5},{"id":"GO:0036494","count":5},{"id":"GO:0006469","count":5},{"id":"GO:0070843","count":5}]},{"hash":"445828689897581793","title":"Developmental patterning and morphogenesis","description":"These GO terms cluster around embryonic development and the formation and patterning of tissues and organs (heart cushion formation, cartilage morphogenesis, left-right axis specification, placenta and endocrine development, germ-line and pancreatic lineage specification). The shared theme is developmental processes governing tissue specification and morphogenesis, despite involvement of multiple organ systems, making this a cohesive label.","confidence":"High","size":27,"edges":18,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0045998","count":4},{"id":"GO:0060806","count":4}]},{"hash":"198168333777715446","title":"Bacterial secondary metabolism and sporulation","description":"The cluster centers on specialized metabolism: antibiotic biosynthesis and response to antibiotics, pigment (melanin) biosynthesis, polyhydroxybutyrate biosynthesis, and other catabolic/biosynthetic pathways (acetoin, propylene, retinol). The inclusion of sporulation links to bacterial developmental programs. Together, these terms define a theme of bacterial secondary metabolism and related developmental processes.","confidence":"High","size":27,"edges":51,"triangles":47,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0017000","count":11},{"id":"GO:0046677","count":11},{"id":"GO:0042208","count":11},{"id":"GO:0006355","count":11}]},{"hash":"1271165031831375675","title":"Neural development and epithelial polarity signaling","description":"This cluster centers on nervous system development and establishment of epithelial cell polarity, supported by signaling pathways such as EGFR and small GTPase\u2013mediated signaling, plus associated cytoskeletal and junction assembly processes. Ancillary terms like ER stress response, copper homeostasis, and cell cycle appear but do not define the main theme, which is developmentally oriented signaling guiding neural and epithelial tissue organization.","confidence":"Medium","size":27,"edges":4,"triangles":1,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0034976","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0007173","count":4}]},{"hash":"1120454922841130155","title":"Cardiac electrical activity and ion transport","description":"The top GO terms cluster around cardiac muscle electrophysiology, including atrial action potential repolarization, heart rate regulation, and ion transport (sodium, calcium, potassium) across the membrane. The cyclic nucleotide responses (cAMP/cGMP) further point to signaling pathways modulating cardiac conduction. A few terms like aerotaxis and touch perception are peripheral, but the dominant theme is cardiac electrical activity and ion handling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":6},{"id":"GO:0098914","count":6},{"id":"GO:0086091","count":5},{"id":"GO:0086002","count":5},{"id":"GO:0098719","count":5}]},{"hash":"1290195341523173999","title":"Glucose-stimulated insulin secretion and membrane dynamics","description":"The cluster centers on insulin secretion regulated by glucose and the signaling systems (GTPase/Rho pathways) that drive vesicle docking and cytoskeletal remodeling. Membrane maintenance aspects (plasma membrane repair and phosphatidylcholine biosynthesis) align with membrane remodeling during secretion. Some stress/inflammatory responses appear as broader cellular context but do not dominate the theme. Overall, the group reflects secretory regulation with membrane/cytoskeletal dynamics.","confidence":"Medium","size":27,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032024","count":3},{"id":"GO:0043087","count":3},{"id":"GO:0035773","count":3},{"id":"GO:0001778","count":3},{"id":"GO:0007416","count":3}]},{"hash":"1818013390165282702","title":"Mitosis and ER-Golgi Vesicle Trafficking","description":"It centers on mitotic cell cycle, spindle assembly, and cell division, with accompanying small GTPase\u2013regulated vesicle transport between the ER and Golgi, pointing to a cohesive role in division-linked trafficking and growth.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0035264","count":3},{"id":"GO:0008283","count":3}]},{"hash":"878371524744499297","title":"Migration and GTPase Signaling","description":"Dominant terms point to cell migration and GTPase-regulated signaling, with related signals for muscle stretch response and adipocyte/foam cell differentiation. While other terms like mRNA processing or telomere maintenance are present, the clearest shared theme is cytoskeletal dynamics and migratory signaling driven by GTPase activity.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016477","count":7},{"id":"GO:0043547","count":6},{"id":"GO:2001275","count":5},{"id":"GO:0032212","count":5},{"id":"GO:1904355","count":5}]},{"hash":"624605606963363204","title":"Embryogenesis and Morphogenesis","description":"This cluster centers on embryonic development programs, including mesoderm formation, left-right patterning, placental and trophoblast differentiation, and endocardial cushion EMT, all core to tissue morphogenesis. Lamellipodium assembly aligns with cell migration during development, while translation reflects basic protein synthesis needed for developmental processes; together these terms point to a cohesive theme of embryogenesis and morphogenesis, with some regulatory terms showing how development is modulated.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0003323","count":2},{"id":"GO:0010957","count":2},{"id":"GO:0003198","count":2}]},{"hash":"2301752108161031081","title":"Unknown","description":"Top terms show a mixed set: cell-cycle processes (DNA replication, mitotic chromosome condensation), neural development (amygdala/spinal cord development, glial growth, astrocyte differentiation), and P granule organization. There\u2019s no clear single function tying all proteins together, so a precise, representative label isn\u2019t justifiable.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0007076","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0019509","count":2}]},{"hash":"2008925364262701097","title":"Gene expression regulation and signaling","description":"This cluster centers on regulation of gene expression and development-related signaling. It includes DNA-templated transcription, both positive and negative regulation of GTPase activity, the Wnt signaling pathway, and mRNA processing/transport, suggesting coordinated control of transcription and signaling during growth and differentiation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0006469","count":2}]},{"hash":"126829776253111629","title":"MAPK signaling regulators","description":"This cluster is dominated by terms pointing to modulation of the MAPK pathway, notably negative regulation of ERK1/ERK2 cascade and Ras signal transduction, suggesting a core role in tuning MAPK activity. Additional GO terms reflect interfaces with hormonal (insulin, estradiol, retinoic acid) and immune signals (molecule of fungal origin, IL-2 production), as well as neural and platelet contexts (CNS development, serotonin secretion by platelets) where MAPK signaling is pivotal. Overall, the proteins appear to function as regulators of MAPK signaling across diverse biological contexts.","confidence":"High","size":27,"edges":19,"triangles":5,"max_degree":7,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071226","count":16},{"id":"GO:0070373","count":11},{"id":"GO:0032869","count":11},{"id":"GO:0071638","count":11},{"id":"GO:0007417","count":11}]},{"hash":"900790213051194717","title":"Regulation of phospholipid biosynthesis and lysosome organization","description":"The strongest signals in this set are terms related to phospholipid biosynthesis (phosphatidylcholine and phosphatidylglycerol) and their regulation, suggesting a core theme of lipid metabolism control. Lysosome organization also appears, indicating a link to organelle homeostasis. Some other terms (e.g., blood-brain barrier establishment, vitamin transport) are more peripheral, so the lipid/metabolic regulation theme best represents the cluster overall.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0090212","count":3},{"id":"GO:0009636","count":3},{"id":"GO:2001247","count":3},{"id":"GO:2000114","count":3},{"id":"GO:0051180","count":3}]},{"hash":"1501708385596582690","title":"Unknown","description":"The top terms span bone and uterus development, immune signaling, cytoskeletal regulation, EMT, and splicing, with no single cohesive function dominating the cluster. This suggests diverse roles rather than a unified process.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":4},{"id":"GO:0002051","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0060335","count":3}]},{"hash":"2105003468723911005","title":"RNA Processing and ERK Signaling in Development","description":"The top terms center on RNA metabolism\u2014splicing via the spliceosome, mRNA decay (deadenylation-dependent and -independent), localization, and cytoplasmic translation\u2014indicating a core RNA-processing module. Additional terms point to ERK signaling and growth-factor response (ERK cascade, EGFR/EGF response) and developmental/immune contexts (cranial skeleton morphogenesis, lymph node development, B cell homeostasis). Together, this suggests proteins involved in RNA processing coupled to ERK-mediated signaling in development and immune function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0048701","count":2},{"id":"GO:0031086","count":1},{"id":"GO:0001782","count":1},{"id":"GO:0070371","count":1}]},{"hash":"1560523975836595953","title":"RNA processing and translation regulation","description":"Most terms cluster around post-transcriptional gene expression: initiation and reinitiation of translation (including viral IRES-driven events) and regulation of translation initiation, together with spliceosome-related splicing and poly(A) tail processing. There is an outlier term for insect cuticle development, but the dominant signal ties to RNA processing and translation control. ","confidence":"Medium","size":26,"edges":250,"triangles":1514,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0008363","count":7},{"id":"GO:0075522","count":6},{"id":"GO:0002188","count":6},{"id":"GO:0006446","count":6},{"id":"GO:0001731","count":6}]},{"hash":"339505472319646460","title":"Unknown","description":"The terms are highly heterogeneous, spanning plant-specific metabolism (cellulose, glucosinolate, lactose catabolism) and signaling (cytokinin pathway) alongside animal development and immunity (midbrain development, insulin signaling, FGFR-MAPK regulation, endothelial barrier, neutrophil fungus killing). There is no single coherent function tying these together, suggesting either a mixed cluster or annotation noise rather than a unified biological theme.","confidence":"","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030245","count":9},{"id":"GO:0030901","count":9},{"id":"GO:0009736","count":8},{"id":"GO:0019762","count":8}]},{"hash":"43032465988376025","title":"RNA processing and ribosome biogenesis","description":"The top GO terms indicate strong enrichment for RNA maturation and processing, including maturation of SSU/LSU rRNA and 5.8S rRNA, as well as spliceosome-mediated mRNA splicing and its regulation/disassembly. This suggests the cluster centers on RNA biology and ribosome assembly, with additional signals of RNA silencing and ubiquitin-mediated regulation that can accompany developmental programs. Overall, a coherent theme around RNA processing and ribosome biogenesis best captures the common function of these proteins.","confidence":"Medium","size":26,"edges":49,"triangles":17,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000463","count":5},{"id":"GO:0000398","count":4},{"id":"GO:0000390","count":4},{"id":"GO:0000209","count":4},{"id":"GO:0048026","count":3}]},{"hash":"547902997215777856","title":"Neural development and motor function with cytoskeletal remodeling","description":"The top GO terms highlight brain-related development (substantia nigra development) and neuromuscular balance, supported by cell organization processes (mitotic spindle assembly, cell polarity) and cytoskeletal remodeling, which are central to neural progenitor proliferation and neuronal morphology. Cholesterol homeostasis also aligns with membrane and synaptic dynamics in neurons. Immune and xenobiotic responses likely reflect general stress responses in neural cells. Overall, the cluster seems best described by neural development and motor function with cytoskeletal dynamics.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050885","count":5},{"id":"GO:0071222","count":4},{"id":"GO:0042632","count":4},{"id":"GO:0008283","count":3},{"id":"GO:0000278","count":3}]},{"hash":"625020427085812487","title":"Membrane transporters for nutrients and xenobiotics","description":"The top GO terms are dominated by transmembrane transport activities (amino acids, taurine, vitamins, xenobiotics, teichoic acids, and oligopeptide export), suggesting the proteins primarily function as membrane transporters. A couple of non-transport terms are present but do not override the main theme.","confidence":"High","size":26,"edges":28,"triangles":23,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042760","count":3},{"id":"GO:0015777","count":3},{"id":"GO:0030153","count":3},{"id":"GO:0015734","count":3},{"id":"GO:0006855","count":3}]},{"hash":"1175779813664197142","title":"Embryonic development and organogenesis","description":"Top GO terms point to broad embryonic development and tissue differentiation rather than a single pathway: pancreatic cell development, endocardial cushion formation via EMT, cartilage morphogenesis, placental-related differentiation, trophoblast giant cell differentiation, endocrine system development, left-right pattern formation, in utero embryonic development, and transcription/splicing processes. This pattern suggests proteins that participate in early development and organogenesis across multiple tissues. The presence of regulatory processes such as mRNA splicing and transcription regulation alongside tissue-specific developmental processes supports a general developmental program rather than a specific function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3}]},{"hash":"1888113928691942747","title":"Meiosis-Chromosome Condensation and Chromatin Silencing","description":"This cluster is dominated by GO terms centering on meiotic chromosome condensation and separation, plus silent mating-type heterochromatin formation and rDNA maintenance, all pointing to meiotic chromosome dynamics and chromatin organization as the shared function. Some terms also touch on genome stability and general cell division, supporting the chromosomal focus, with amyloplast organization likely an outlier in this context.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0009660","count":3},{"id":"GO:0007076","count":3},{"id":"GO:0051301","count":3},{"id":"GO:1903342","count":3}]},{"hash":"912660563745280245","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0009102","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0042264","count":3}]},{"hash":"233580957489218346","title":"Membrane Trafficking and Xenobiotic Response","description":"The cluster is enriched for endosome-to-lysosome transport, exocytosis regulation, and phospholipid homeostasis, all pointing to membrane trafficking and vesicle dynamics. It also includes responses to lipopolysaccharide and xenobiotic stimuli, plus membrane transport (glucose) and gene expression regulation, suggesting a coordinated membrane-centric signaling program involved in immune/xenobiotic sensing and metabolic regulation. This combination supports a theme around vesicle trafficking coupled to external-stimulus responses.","confidence":"Medium","size":26,"edges":13,"triangles":2,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071222","count":6},{"id":"GO:0015758","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0045956","count":4},{"id":"GO:0010628","count":4}]},{"hash":"972569543726715327","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around developmental processes across multiple tissues (pancreatic development, EMT in heart formation, cartilage morphogenesis, placenta/differentiation, left-right patterning, endocrine development). While there are some general processes (splicing and ubiquitin-dependent degradation), the shared theme is embryonic development and tissue morphogenesis rather than a single pathway, making this a coherent developmental cluster. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060536","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0060707","count":7}]},{"hash":"1001397735951406951","title":"Nutrient and lipid membrane transport","description":"The cluster is characterized by GO terms centered on transmembrane transport of xenobiotics and vitamins, along with cholesterol homeostasis and intestinal cholesterol absorption, indicating a role in nutrient uptake and lipid handling across membranes. Additional terms like nutrient response and receptor clustering support a membrane-organization and signaling context, while a few development terms are likely secondary annotations. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0006855","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0030299","count":2}]},{"hash":"623593169282550636","title":"Inflammation-Driven Metabolic Tissue Remodeling","description":"This cluster shows inflammatory processes (inflammatory response, platelet activation, pain perception) alongside metabolic/thermogenic programs (diet-induced thermogenesis, regulation of feeding behavior) and developmental tissue remodeling (nipple morphogenesis, lung connective tissue development, metanephric glomerulus development). The shared theme appears to be inflammation-associated metabolic remodeling and tissue development/remodeling rather than a single highly specific function.","confidence":"Medium","size":26,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":7},{"id":"GO:0030168","count":7},{"id":"GO:0072224","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0006954","count":7}]},{"hash":"1845547166453115354","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":8,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009718","count":6},{"id":"GO:0042619","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0009103","count":5},{"id":"GO:0009242","count":5}]},{"hash":"1863262706120905856","title":"Developmental Differentiation and Transcriptional Regulation","description":"The terms center on development and cell differentiation (nervous system, intestinal epithelial differentiation; granulocyte differentiation) and on transcriptional control (DNA-templated transcription initiation; RNA Pol II preinitiation complex assembly), with Notch signaling regulation and stem cell proliferation also represented, suggesting a cluster of factors governing developmental decisions via transcriptional regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060670","count":3},{"id":"GO:0045746","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0060575","count":2},{"id":"GO:0006352","count":2}]},{"hash":"2264288838839358590","title":"Insect pigmentation and caste-related biology","description":"Top terms cluster around melanin biosynthesis from tyrosine and cuticle pigmentation, plus caste determination influenced by environmental factors and associated mating behavior, all hallmark features of insect development and social biology. While a few terms (inflammatory mediator production and cardiac signaling) seem less coherent with this theme and may reflect annotation noise, the strongest signal is pigmentation and caste/mating-related processes.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0090197","count":4},{"id":"GO:0048067","count":4},{"id":"GO:0060179","count":4},{"id":"GO:0006583","count":4},{"id":"GO:0048650","count":4}]},{"hash":"2204833534813999985","title":"Cytokine-mediated innate immune activation","description":"Based on the GO terms, the cluster centers on immune signaling and inflammatory cytokine production, especially macrophage cytokine production, IL-6 and TNF, and mast cell\u2013mediated immunity with opsonization. Although there are a few translation/regulatory terms and a vascular development term, the strongest and most frequent themes are cytokine production and innate immune responses, justifying a label focused on cytokine-driven innate immunity.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0010793","count":2},{"id":"GO:0043152","count":1},{"id":"GO:0060907","count":1},{"id":"GO:0032755","count":1}]},{"hash":"1437491859312663999","title":"Redox-Associated Metabolism and Biosynthesis","description":"The cluster shows GO terms spanning redox-related processes (oxidation-reduction and redox homeostasis), fatty acid beta-oxidation, and various biosynthetic and catabolic pathways (amino acids, quinones, phenylacetate, antibiotics). The mix suggests a set of metabolic functions linked to energy production and redox balance, possibly from microbes or mitochondria-associated contexts, rather than a single narrow pathway. Therefore, a label emphasizing redox-linked metabolism and biosynthesis is most representative, with moderate confidence due to the diversity of terms.","confidence":"Medium","size":25,"edges":252,"triangles":1499,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0030150","count":3},{"id":"GO:0009098","count":3},{"id":"GO:0009234","count":2},{"id":"GO:0042372","count":2}]},{"hash":"715547794500460094","title":"Neurotransmitter Biosynthesis and Signaling","description":"The cluster is dominated by GO terms for biosynthesis of major neurotransmitters\u2014dopamine, serotonin, and GABA\u2014pointing to a core function in neurotransmitter production and neural signaling. Additional terms about growth-factor\u2013related signaling, cell migration, and other cellular responses suggest broader signaling roles or annotation noise, but the strongest signal centers on neurotransmitter synthesis and related signaling pathways.","confidence":"Medium","size":25,"edges":57,"triangles":107,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0010761","count":6},{"id":"GO:0006585","count":6},{"id":"GO:0006587","count":6},{"id":"GO:0033327","count":6}]},{"hash":"1365062043791754862","title":"Neural development and synaptic signaling","description":"This cluster is enriched for nervous system\u2013related processes, including retina development, presynaptic terminal organization, active zone cytoskeletal dynamics, and both excitatory and inhibitory postsynaptic potentials, with acetylcholine turnover in the synapse, pointing to a cohesive role in neural development and synaptic function.","confidence":"High","size":25,"edges":289,"triangles":2058,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0002076","count":15},{"id":"GO:0060041","count":15},{"id":"GO:0002087","count":15},{"id":"GO:0008285","count":11},{"id":"GO:0006366","count":10}]},{"hash":"268637751478724024","title":"Neural crest\u2013driven axon guidance","description":"The proteins appear to cluster around neural development and axon guidance, with pathways like semaphorin-plexin signaling, branchiomotor and trigeminal neuron axon guidance, sympathetic neuron projection, and neural crest\u2013related migration that ties into heart development. A voltage-gated potassium channel clustering term may reflect neuronal maturation context, but the dominant signal is guidance and connectivity formation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045163","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0036486","count":3}]},{"hash":"1315016971729320576","title":"Viral Integration and Proviral Latency","description":"The GO terms cluster around DNA integration, recombination, and replication, with specific emphasis on viral entry into the host nucleus and establishment of integrated proviral latency, plus RNA-templated DNA synthesis. This pattern strongly points to a retroviral-like lifecycle involving genome integration and latent provirus maintenance, with additional signals of host-pathogen interactions (apoptosis modulation and RNAi pathway regulation) that can accompany symbiont or viral infections.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0006310","count":6},{"id":"GO:0006260","count":5},{"id":"GO:0075732","count":4},{"id":"GO:0046718","count":4}]},{"hash":"469615707084643155","title":"Spermatogenesis and protein ubiquitination","description":"Most informative terms point to germ cell development (spermatogenesis and spermatid development) and protein ubiquitination, suggesting this cluster centers on sperm development with ubiquitin-mediated protein regulation. Additional terms for clathrin-mediated endocytosis and stress fiber assembly hint at broad cellular trafficking and cytoskeletal dynamics accompanying germ cell maturation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0009951","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0032092","count":1}]},{"hash":"560070239117792443","title":"Bacterial polysaccharide and lipid biosynthesis","description":"This cluster is dominated by GO terms for lipopolysaccharide biosynthesis, galactose metabolism, menaquinone biosynthesis, poly-hydroxybutyrate biosynthesis, and fatty acid transport\u2014together indicating a theme of bacterial (prokaryotic) macromolecule and cell envelope biosynthesis. Some outlier terms (e.g., immune-related processes) appear as noise, but the strongest signal is bacterial lipid and polysaccharide production. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:1902987","count":8},{"id":"GO:0009103","count":6},{"id":"GO:0060716","count":6},{"id":"GO:0006012","count":6}]},{"hash":"188462021860374638","title":"Viral translation initiation and RNA export","description":"The top GO terms cluster around viral control of host translation: IRES-dependent viral translation initiation, formation of the translation preinitiation complex, regulation of translational initiation, viral mRNA export from the host nucleus, and related ubiquitin ligase activity. This suggests the proteins in this cluster are enriched for roles in how viruses hijack host translation and RNA export machinery, with a few cytoskeletal or mitotic terms that are less central to this theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0075525","count":2}]},{"hash":"1406058773256982151","title":"Neuronal development and synaptic signaling","description":"The cluster is dominated by GO terms tied to synapse structure and function (active zone organization, receptor internalization, acetylcholine catabolic process in the synaptic cleft, and modulation of excitatory/inhibitory postsynaptic potentials) and neuronal development cues (retina development), indicating a coherent theme of synaptic signaling and neuronal maturation; outlier terms like retina and osteoblast development may reflect broader developmental roles but do not override the synaptic core.","confidence":"High","size":25,"edges":279,"triangles":1867,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":14},{"id":"GO:0060041","count":14},{"id":"GO:0002076","count":14},{"id":"GO:0002087","count":14},{"id":"GO:0072553","count":13}]},{"hash":"1594567754369310533","title":"Embryonic Development and Ubiquitin-Regulated Differentiation","description":"The GO terms cluster around embryonic development and tissue morphogenesis (heart EMT and endocardial cushion formation, left-right patterning, placenta/trophoblast, endocrine and pancreatic development) with supporting roles for protein turnover (polyubiquitination, ubiquitin-dependent degradation) and RNA processing (spliceosome). This suggests a cohesive theme of developmentally regulated differentiation guided by protein turnover and splicing.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0003198","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0000209","count":6},{"id":"GO:0060806","count":6}]},{"hash":"1271186138175812858","title":"Embryogenesis and organogenesis","description":"This cluster is dominated by GO terms tied to embryonic development and tissue/organ formation, including pancreatic cell development, heart-related EMT in endocardial cushion formation, cartilage morphogenesis, placenta and trophoblast differentiation, and left-right patterning. While a couple terms touch on general cellular processes, the prevailing theme is embryogenesis and organ development, suggesting these proteins cooperate in early lineage specification and organogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060707","count":4}]},{"hash":"1003051003114621327","title":"Proviral integration and host genome manipulation","description":"The cluster's top GO terms center on viral entry into host nucleus and proviral latency, along with DNA recombination, DNA integration, and RNA-templated DNA synthesis, suggesting a shared theme of viral/proviral genome integration and manipulation of host DNA replication. There are additional signals related to RNA interference regulation and lipid metabolism, but the dominant pattern is genome integration and host genome alteration. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075732","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0006278","count":4}]},{"hash":"1524283858436827232","title":"Developmental and Detoxification Regulators","description":"The top GO terms cluster around developmental processes in multiple tissues (digestive tract, uterus, female gonad, hepatocyte differentiation) and xenobiotic catabolic/metabolic activity, implying a theme of development coupled with detoxification. A stress-related term (response to immobilization stress) fits with a broader stress-responsive developmental/detox axis, though a few terms (DNA recombination/transposition) are less clearly linked but may reflect genome dynamics in these contexts. Overall, the cluster likely represents proteins involved in development and detoxification pathways under stress.","confidence":"Medium","size":25,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0035902","count":6},{"id":"GO:1900087","count":5},{"id":"GO:0042738","count":5},{"id":"GO:0006310","count":4},{"id":"GO:0048565","count":4}]},{"hash":"1382487562441926932","title":"Drosophila egg chamber and follicle cell development","description":"GO terms are dominated by processes in Drosophila oogenesis, especially follicle cell development in the egg chamber and germarium-derived germline cyst formation. Additional terms touch on transcription regulation and chromatin modifications, which may reflect related regulatory programs in developing ovaries. Together, the cluster appears to represent oogenesis and follicle cell differentiation in the Drosophila ovary.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045892","count":1},{"id":"GO:0030154","count":1},{"id":"GO:0008283","count":1},{"id":"GO:0030707","count":1},{"id":"GO:0030730","count":1}]},{"hash":"1309768564583746789","title":"Mitochondrial energy metabolism and insulin signaling","description":"These proteins show a strong bias toward mitochondrial respiration and electron transport, plus insulin-related catabolic and signaling processes, suggesting a module focused on energy production regulated by hormonal signaling. Additional terms like proteolysis regulation and protein assembly may reflect broader cellular homeostasis but do not outweigh the core mitochondrial-hormonal theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0009060","count":5},{"id":"GO:0051289","count":4},{"id":"GO:0016032","count":3},{"id":"GO:1901143","count":3},{"id":"GO:0008286","count":3}]},{"hash":"653624707976762706","title":"Immune signaling and neural development proteins","description":"The top GO terms show immune defense (innate immune response, defense response to virus) alongside neural development processes (axonogenesis, axon extension). Additional signals (GPCR signaling, receptor tyrosine kinase signaling, I-kappaB phosphorylation) and ECM/cell adhesion roles (collagen fibril organization, substrate adhesion-dependent cell spreading) point to a common theme of signaling-regulated responses relevant to immunity and neural development, despite lack of direct inter-protein edges. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045842","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0008277","count":3}]},{"hash":"1326869248550438788","title":"Chorion Formation and Development","description":"The top GO terms center on multicellular organism development, with explicit mentions of chorion-containing eggshell formation, kidney and male gonad development, and extracellular matrix organization, suggesting a cluster of proteins involved in developmental and reproductive tissue formation. Some transport and neural-related terms appear but are less central to the core theme. Medium","confidence":"","size":24,"edges":53,"triangles":12,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0007304","count":3},{"id":"GO:0001970","count":2},{"id":"GO:0043252","count":2},{"id":"GO:0030198","count":2}]},{"hash":"1746484385160938912","title":"Membrane Transporters and Related Processes","description":"Top GO terms indicate a focus on transmembrane transport activities (taurine, xenobiotic, cGMP, abscisic acid transport) and related processes (oligopeptide export from mitochondrion, teichoic acid transport, xenobiotic transport), with other terms like very long-chain fatty acid catabolism and DNA integration representing more peripheral annotations. The lack of edges suggests these proteins are not tightly connected into a single functional module, but the prevailing theme is membrane-associated transport. Confidence: Medium.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0042760","count":5},{"id":"GO:0015777","count":5},{"id":"GO:0030153","count":5},{"id":"GO:0015734","count":5}]},{"hash":"2274880844391242804","title":"Retroviral DNA Integration and Proviral Latency","description":"The GO terms point to steps in the retroviral life cycle: entry into the host, nuclear penetration, reverse transcription (RNA-templated DNA synthesis), DNA integration and recombination, and establishment of proviral latency. Additional terms indicate host\u2013virus interactions such as suppression of siRNA processing and virus-induced apoptosis, with a nearby outlier term for monoterpene biosynthesis. This combination strongly supports a cohesive theme around retroviral genome integration and proviral latency with host interaction. ","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0006310","count":7},{"id":"GO:0075732","count":5},{"id":"GO:0046718","count":5},{"id":"GO:1903704","count":5}]},{"hash":"2059471239876504822","title":"RNA processing and translation initiation regulation","description":"Reasoning: The cluster is dominated by GO terms related to translation initiation control (translation reinitiation, preinitiation complex formation, regulation of translational initiation) and viral translation mechanisms, indicating a core role in controlling protein synthesis. Additional terms point to RNA processing activities (splicing, transcription regulation by RNA Pol II) and mRNA maturation, suggesting these proteins broadly coordinate post-transcriptional gene expression. Some terms reflect growth or defense, but the strongest signal centers on translation initiation regulation and RNA processing.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0006446","count":4},{"id":"GO:0075525","count":4}]},{"hash":"107590282337242856","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":87,"triangles":207,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0010224","count":7},{"id":"GO:0006547","count":7}]},{"hash":"951710201784280181","title":"Neural development and cytoskeletal signaling","description":"The top GO terms point to neural and epidermal development (neural tube closure, neuron projection development, skin development) and cell proliferation, alongside regulation of cytoskeleton dynamics (Arp2/3, GTPase activity) and signaling (kinase activity) as well as RNA processing during development. This suggests a cohesive theme of developmental signaling coordinated with cytoskeletal remodeling, rather than a single isolated process.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051028","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0001843","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0000398","count":5}]},{"hash":"1161859627470780559","title":"Immune Activation and Signaling Regulation","description":"The cluster is enriched for immune-related processes: T cell activation via T cell receptor interaction with antigen-MHC (GO:0002291), B cell homeostasis (GO:0001782), and activation-induced cell death of T cells (GO:0006924), plus a cellular response to GM-CSF stimulus (GO:0097011). These point to adaptive and myeloid signaling involvement. Additional terms like negative regulation of Ras signaling (GO:0046580), regulation of ARF signaling (GO:0032012), and GPCR pathway modulation (GO:0030845) suggest broader regulation of signaling cascades. Ribosome biogenesis (GO:0042254) appears as a less specific, background process. Overall, the dominant theme is immune cell activation and immune signaling regulation.","confidence":"High","size":24,"edges":6,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0046580","count":3},{"id":"GO:0006924","count":3},{"id":"GO:0001782","count":3},{"id":"GO:0031999","count":3}]},{"hash":"2284278103131208297","title":"Synaptic signaling and organization","description":"This cluster is defined by multiple synapse-focused GO terms: terminal button organization, active-zone cytoskeletal matrix organization, receptor internalization, acetylcholine catabolic process in the synaptic cleft, and modulation of excitatory and inhibitory postsynaptic potentials. Retina development and nervous-system regulation of respiration contexts suggest neural tissue involvement, reinforcing the theme of synaptic assembly and neurotransmission across neural circuits.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":15},{"id":"GO:0002076","count":15},{"id":"GO:0002087","count":15},{"id":"GO:0072553","count":14},{"id":"GO:2000463","count":14}]},{"hash":"1763440794512659117","title":"Axon pathfinding and synapse assembly","description":"The top GO terms are dominated by neural development processes: axonal fasciculation, branching morphogenesis of a nerve, and positive regulation of synapse assembly, which together point to guidance and formation of neural connections. While other terms (transcription regulation, viral processes, endothelial proliferation, G-protein assembly) appear, the strongest signal centers on neuron development and synapse organization, justifying a label focused on axon guidance and synapse formation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0048755","count":2}]},{"hash":"1140558837118156966","title":"Ion and Nutrient Membrane Transporters","description":"The GO terms show transmembrane transport for multiple ions (sodium, potassium, phosphate, nitrate) and substrates (xenobiotics, vitamins, sugars like fucose), plus a vesicular transport term (neurotransmitter loading into synaptic vesicle), pointing to a cluster of transporter proteins with broad substrate specificity across membranes and into vesicles. This cohesive theme justifies labeling as Ion and Nutrient Membrane Transporters.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0006855","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015739","count":3}]},{"hash":"1726778161692176713","title":"Unknown","description":"This cluster shows a mix of immune-related terms (innate immune response, response to lipopolysaccharide, B cell receptor signaling, response to dsRNA), apoptosis, and developmental terms (skeletal muscle development, corpus callosum development). With no cohesive functional theme or demonstrated interactions tying these terms together, there is no clear common function to name the cluster.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0031397","count":3}]},{"hash":"1199353663225605892","title":"Developmental growth and cell division proteins","description":"The cluster features GO terms tied to embryonic organ development, neuron projection development, lens fiber cell differentiation, and general growth and cell division, pointing to proteins involved in development and proliferation/differentiation. The presence of ER-Golgi transport and ubiquitin-dependent ERAD terms suggests these proteins may also participate in secretory pathway quality control, which can be critical during development. Overall, the theme centers on developmental processes with connections to the cell cycle and differentiation.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0006888","count":6},{"id":"GO:0035264","count":5},{"id":"GO:0007568","count":5},{"id":"GO:0007064","count":5}]},{"hash":"64196900715811188","title":"Pathogen Entry and Host Signaling Manipulation","description":"The top GO terms strongly point to interactions between pathogens (viruses and symbionts) and host cells: entry into host cells and nuclei, DNA integration and proviral latency, symbiont-induced host apoptosis, and modulation of Rho/Rac signaling. While some developmental terms appear, the cohesive theme is host-pathogen or host-symbiont manipulation of cellular entry, genome integration, and signaling pathways. Overall, the cluster seems to reflect mechanisms by which pathogens or symbionts interact with and alter host cell processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0048745","count":4},{"id":"GO:0048485","count":4},{"id":"GO:0048593","count":4}]},{"hash":"601419316131467756","title":"Unknown","description":"The GO terms span neural development, circadian and rhythmic regulation, histamine secretion, nucleotide metabolism, cell adhesion, and various developmental processes, with no dominant shared function pulling the proteins together. The lack of network connectivity (no edges/triangles) and the scattered terms indicate no cohesive theme.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0001821","count":2},{"id":"GO:0042323","count":2},{"id":"GO:0006178","count":2},{"id":"GO:0045987","count":2}]},{"hash":"1432485907453158724","title":"Ion Transporters and Vesicle Loading","description":"The top GO terms cluster around transmembrane transport of ions and small molecules (sodium, potassium, phosphate, nitrate, sialic acid, xenobiotics, vitamins, fucose) and a process related to loading neurotransmitters into synaptic vesicles, pointing to a cohort of membrane transporters and vesicle-trafficking components. While one term notes innate immune response, the dominant signal is membrane transport function across substrates, suggesting a cohesive transporter/trafficking theme for the cluster.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0035461","count":3}]},{"hash":"1078042906677383902","title":"Organ and neural development","description":"These proteins show enrichment for multiple developmental processes, spanning heart/pulmonary myocardium development, brain development (midbrain, neuron migration, synapse assembly), organ induction, and multicellular organism development. The common theme is developmental programs rather than a single molecular function, so this label best captures the cluster. An isolated complement activation term may be incidental rather than indicative of a shared function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0030901","count":3},{"id":"GO:0000122","count":3}]},{"hash":"527930619748809050","title":"Mitochondrial translation and respiratory chain assembly","description":"The prominent terms point to mitochondrial processes: assembly of ETC complexes I and III, electron transport from ubiquinol to cytochrome c, proton transport and aerobic respiration, plus iron-sulfur cluster assembly and a translation term. Together they suggest a cluster enriched for mitochondrial protein synthesis and respiratory chain biogenesis.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0032981","count":2},{"id":"GO:0006122","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0009060","count":1}]},{"hash":"1568575662071192187","title":"Muscle Ca2+ signaling and ion transport","description":"The terms cluster around calcium homeostasis and calcium/membrane transport (calcium ion transmembrane transport, intracellular calcium ion homeostasis) with concurrent regulation of sodium transport and a muscle-specific context such as transition between fast and slow muscle fibers. Vitamin D response and NOS regulation imply integrated signaling affecting muscle function and vascular tone, with a subset touching P450 epoxygenase pathways. Overall, the data point to a muscle-focused Ca2+- and ion-transport theme as the core cluster function.","confidence":"Medium","size":23,"edges":33,"triangles":22,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006874","count":3},{"id":"GO:0002028","count":3},{"id":"GO:0070588","count":3}]},{"hash":"1590304116184256229","title":"Stress-Responsive Proteostasis and Signaling","description":"This cluster centers on protein quality control and stress response: ubiquitin-dependent ERAD and autoubiquitination point to proteostasis and degradation, while MAPK signaling, ROS regulation, heat response, and light stress reflect broader stress-activated pathways that maintain protein homeostasis. The axonal transport and muscle contraction terms may reflect context-specific roles of proteostasis in specialized cells, but overall the theme is proteostasis coupled with stress signaling.","confidence":"Medium","size":23,"edges":179,"triangles":974,"max_degree":20,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0030433","count":9},{"id":"GO:0051865","count":8},{"id":"GO:0051403","count":7},{"id":"GO:2000378","count":7},{"id":"GO:0099641","count":7}]},{"hash":"1483714913886186240","title":"Mitochondrial Energy Metabolism","description":"The cluster is enriched for mitochondrial-centric metabolic processes: TCA cycle, pyruvate biosynthesis, alanine catabolism, and kynurenine/tryptophan catabolic activity, plus mitochondrial translation, pointing to energy production and mitochondrial function. Additional terms like response to glucocorticoid and cAMP reflect linked stress signaling, while Notch signaling appears only modestly. Together these suggest a coherent theme of mitochondrial metabolism with associated signaling.","confidence":"Medium","size":23,"edges":189,"triangles":1007,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0097053","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0051384","count":3},{"id":"GO:0051591","count":3},{"id":"GO:0042853","count":3}]},{"hash":"702696381442152644","title":"Embryonic development and organ morphogenesis","description":"The cluster\u2019s GO terms are dominated by embryonic development and morphogenesis across multiple tissues (pancreatic cell development, heart/EMT, placenta differentiation, cartilage formation, left-right patterning, endocrine development, etc.), suggesting a general developmental program rather than a single, specific function. Protein polyubiquitination appears as a broader regulatory process but does not define a unique shared function for all members.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0007279","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3}]},{"hash":"446883118558536775","title":"Vascular coagulation and innate immune response","description":"The top GO terms converge on coagulation (Factor XII activation) and endothelial barrier establishment, with accompanying innate immune activities such as neutrophil-mediated killing and response to lipopolysaccharide, along with tissue remodeling. Together these point to a vascular-immune remodeling theme. Some terms (midbrain development, biomineral tissue development) may reflect secondary or multi-functional roles rather than a single core function of the cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0032496","count":8},{"id":"GO:0031214","count":8},{"id":"GO:0030194","count":8}]},{"hash":"1838049578103935425","title":"Transcriptional control in vascular and immune development","description":"Top GO terms show regulation of RNA polymerase II transcription (both positive and negative) together with developmental, vascular, and immune-related processes (midbrain development, endothelial barrier establishment, coagulation, antimicrobial defense). With no edges connecting proteins, the cluster likely represents general transcriptional regulators involved in developmental and vascular-immune contexts, hence the label. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0045944","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0035264","count":6},{"id":"GO:0031214","count":6}]},{"hash":"297284832390962105","title":"Adrenergic GPCR signaling and cardiovascular regulation","description":"The cluster is dominated by GO terms tied to adrenergic GPCR pathways that activate adenylate cyclase, regulate heart rate and blood pressure, and influence hormone secretion. Additional terms point to GPCR signaling linked to cGMP, feeding behavior, grooming, and smooth muscle modulation, suggesting a neuromodulatory program coordinating cardiovascular and behavioral responses. The electron transport chain term is less central but may reflect energy needs for signaling functions.","confidence":"High","size":23,"edges":96,"triangles":221,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0060259","count":17},{"id":"GO:0001996","count":17}]},{"hash":"801768562704754439","title":"Retroviral DNA integration and latency","description":"These proteins cluster around steps of the retroviral life cycle: reverse transcription (RNA-templated DNA biosynthesis), DNA integration into the host genome, and establishment of proviral latency, plus related host-entry and host-pathogen interaction terms. While some terms (e.g., symbiont entry) are broader, the core pattern is retroviral genome integration and latency coupled with host interactions.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006278","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0006310","count":3}]},{"hash":"136737264318292109","title":"Unknown","description":"The Top Terms show a mix of innate immune response, metabolism, light sensing, plant growth signaling, transcription regulation, and heme/chlorophyll linkage. With no edges or cohesive pathway, and GO terms spanning both plant and animal processes, there isn\u2019t a single clear function tying the cluster together. Therefore Unknown.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0000160","count":2},{"id":"GO:0010510","count":2},{"id":"GO:0080117","count":2},{"id":"GO:0009584","count":2}]},{"hash":"1308256035603331103","title":"Developmental and Innate Immune Regulation","description":"The cluster shows GO terms across development (heart, neuron, bone, metamorphosis) and innate immunity (innate immune response, NLRP3 inflammasome assembly), with additional hints of RNA metabolism and translation regulation (mRNA deadenylation/decapping). This suggests proteins involved in coordinating gene expression during development while also engaging innate immune signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000288","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0048666","count":2},{"id":"GO:1900227","count":2},{"id":"GO:0045087","count":2}]},{"hash":"1190822335659106315","title":"GTPase- and PI-mediated Signaling Regulation","description":"The top GO terms point to regulation of GTPase activity, phosphatidylinositol-mediated signaling, and related signaling processes (including modulation of insulin signaling and cell migration). Although there are no direct interactions among members in this cluster, the common thread is regulation of signaling pathways rather than a single concrete function, suggesting a general signaling regulatory role.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0045945","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0048015","count":2},{"id":"GO:0007205","count":2}]},{"hash":"1402436044158994876","title":"B cell signaling and cytokine production","description":"Top GO terms indicate adaptive immune signaling, particularly B cell receptor signaling, and cytokine production (IL-2 and IL-4). The enrichment of ERK1/2 cascade regulation supports a signaling-activation theme, while other terms reflect broader immune/stress responses. Together, these terms point to a protein cluster focusing on lymphocyte signaling and cytokine regulation rather than general metabolism.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0060396","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0006351","count":3}]},{"hash":"1977351664915856887","title":"Embryonic organogenesis and tissue development","description":"All top GO terms describe embryonic development across diverse tissues (pancreatic, placental, cardiac, craniofacial/palatal, cartilage) and patterning. This suggests a cluster of proteins involved in general embryogenesis and organ formation rather than a single pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0010957","count":6},{"id":"GO:0003198","count":6},{"id":"GO:0007498","count":6},{"id":"GO:0060806","count":6}]},{"hash":"2030556315099166558","title":"ECM Remodeling and Vascular Development","description":"The cluster is dominated by GO terms for extracellular matrix turnover (collagen catabolic process, extracellular matrix disassembly) and tissue remodeling, plus vascular-related processes such as blood coagulation and establishment of the endothelial barrier, with additional developmental terms (midbrain development, amelogenesis) that suggest a broader role in developmental remodeling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030574","count":6},{"id":"GO:0097186","count":6},{"id":"GO:0022617","count":6},{"id":"GO:0007596","count":6}]},{"hash":"324827975619346063","title":"Ribosome biogenesis and RNA maturation","description":"The dominant GO terms center on ribosome-related processes: maturation of LSU- and 5.8S rRNA and RNA guanine-N7 methylation, all core to ribosome biogenesis and RNA processing. Additional terms referencing cell division and DNA replication fit growth-associated needs that accompany ribosome production, while immune and neural terms appear less central and may be incidental. Overall, the core theme is ribosome biogenesis and RNA maturation rather than a single signaling or specialized pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0000463","count":3},{"id":"GO:1903461","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0007584","count":3}]},{"hash":"1655697372756896352","title":"Prostaglandin biosynthesis and reproductive development","description":"The top GO terms center on prostaglandin biosynthetic process and multiple aspects of reproductive development (female genitalia development, uterus and female gonad development, prostate gland growth). The inclusion of hormonal and inflammatory regulation signals suggests a coherent theme linking prostaglandin pathways with reproductive tract development and endocrine regulation. Thus, the cluster can be described as prostaglandin-related processes tied to reproductive development.","confidence":"Medium","size":23,"edges":18,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":15},{"id":"GO:0030540","count":13},{"id":"GO:0002677","count":13},{"id":"GO:0060736","count":13},{"id":"GO:0035865","count":13}]},{"hash":"1903451398480775522","title":"Embryonic development and immune/neural signaling","description":"The top GO terms center on tissue development (heart, placenta) and neural development (axonogenesis), alongside immune differentiation (IL-4 production, NK T cell differentiation) and signaling-related processes (calcium/ion signaling and exocytosis). This suggests a cluster of proteins involved in multi-tissue developmental signaling rather than a single, narrow function, spanning cardiovascular, neural, placental, and immune contexts.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0010765","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0045956","count":4},{"id":"GO:0007409","count":4}]},{"hash":"2289258559650887518","title":"Translation Initiation Complex Formation and Regulation","description":"This cluster is dominated by GO terms for forming translation initiation complexes (preinitiation and cytoplasmic) and regulating translational initiation, indicating a core function in initiating protein synthesis. While other terms (chromatin organization, brain development, mitotic cycle, etc.) appear among targets, the strongest signal centers on translation initiation processes.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0031497","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0000278","count":2}]},{"hash":"2081881221158825468","title":"N-terminal acetylation cluster","description":"This cluster shows a strong enrichment for N-terminal acetylation-related GO terms (N-terminal peptidyl-glutamic acid/methionine acetylation, N-terminal protein amino acid propionylation, etc.), suggesting the proteins share a common function in or regulation by N-terminal acetylation. While other terms appear (angiogenesis, heterochromatin formation, various catabolic and biosynthetic processes), they are less central to the dominant theme of post-translational modification at the N-terminus.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006348","count":10},{"id":"GO:0001525","count":9},{"id":"GO:0006526","count":7},{"id":"GO:0061606","count":7},{"id":"GO:0045150","count":7}]},{"hash":"846600398471384483","title":"Embryogenesis and Organogenesis","description":"The GO terms are dominated by embryonic development and tissue differentiation (pancreatic cell development, EMT in endocardial cushion, cartilage morphogenesis, left-right patterning, trophoblast differentiation, placenta-related processes, endocrine system development), suggesting a shared role in embryogenesis and organ formation, with a smaller subset related to rRNA processing that is less central to the cluster\u2019s main theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060806","count":3}]},{"hash":"916802782029227805","title":"Mitotic spindle assembly and microtubule organization","description":"This cluster is driven by GO terms centered on microtubule dynamics and mitosis (cell cycle, microtubule nucleation, spindle midzone assembly, cytoplasmic microtubule organization, and cytokinesis), indicating a core role in cytoskeletal architecture during cell division. Additional terms for translation and protein polymerization reflect general cellular biosynthesis supporting proliferation, while neuron migration and mechanosensory regulation hint at cytoskeleton-driven remodeling during development and sensory processes. Overall, the proteins likely coordinate microtubule-based organization and division, with some involvement in movement and mechanosensation pathways.","confidence":"High","size":22,"edges":25,"triangles":10,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0051258","count":3},{"id":"GO:0001764","count":3},{"id":"GO:0007020","count":3}]},{"hash":"1422040940875645943","title":"Transmembrane Transporters and Vesicular Loading","description":"The cluster is dominated by multiple transmembrane transport GO terms (ions and metabolites) and a vesicular neurotransmitter loading process, suggesting a group of membrane transporter proteins involved in ion/metabolite flux and vesicle-related neurotransmission.","confidence":"High","size":22,"edges":16,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0006855","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0098700","count":2}]},{"hash":"1550915169192102376","title":"Unknown","description":"The top GO terms cover a wide and disjoint set of functions, including development (cell morphogenesis, skeletal system development), cell cycle and chromosome organization (DNA replication, meiotic cell cycle, kinetochore localization), metabolism (glycogen and glucose metabolic processes), apoptosis, neuronal signaling (excitatory postsynaptic potential), and even lipid A biosynthesis. This broad mix lacks a single cohesive biological theme or pathway, indicating the cluster represents heterogeneous or unrelated functions rather than a specific, interpretable module.","confidence":"","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000902","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0005978","count":4},{"id":"GO:0009245","count":4},{"id":"GO:0001501","count":4}]},{"hash":"2135650559219014924","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0038202","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007584","count":3}]},{"hash":"955212317366132739","title":"Developmental regulation and gene expression machinery","description":"This cluster includes GO terms for organ development (heart, mammary gland duct morphogenesis, parathyroid development) alongside core gene expression processes (transcription, splicing, translation initiation, preinitiation complex formation, and proteasomal regulation). The combination suggests proteins involved in developmental signaling that interfaces with fundamental transcription/translation control, making a label that reflects both aspects appropriate.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060444","count":3},{"id":"GO:0060017","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0000398","count":3}]},{"hash":"1555962449788627019","title":"Brain and neural development","description":"The cluster's top GO terms are dominated by brain- and neural-development processes (brain development, midbrain and subthalamic nucleus development, peripheral nervous system neuron development) with related locomotory behavior, pointing to a neural-development program. A few terms about early embryogenesis (primitive streak formation, fertilization) appear but overall the theme is neural development.","confidence":"High","size":22,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0007338","count":8},{"id":"GO:0007420","count":7},{"id":"GO:0008584","count":7},{"id":"GO:0030901","count":7}]},{"hash":"2115934936864745682","title":"Stress-Responsive Transcription and Translation Regulation","description":"The top GO terms point to cellular responses to xenobiotic stimuli and drugs (xenobiotic stimulus, cocaine) alongside regulation of gene expression, including transcription elongation by RNA polymerase II and translational initiation via eIF2\u03b1 dephosphorylation. This suggests the proteins collectively participate in stress-response pathways that modulate transcription and translation. Some terms like lung development, dendrite morphogenesis, and meiotic DSB formation are more peripheral but may reflect broader regulatory or pleiotropic roles. Overall, the cluster appears to reflect coordinated regulation of gene expression under stress rather than a single narrow function.","confidence":"Medium","size":22,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035690","count":5},{"id":"GO:0030324","count":4},{"id":"GO:0006517","count":4},{"id":"GO:0034244","count":3},{"id":"GO:2000002","count":3}]},{"hash":"2042413143775334803","title":"Synapse organization and neurotransmission","description":"Most enriched terms point to presynaptic and postsynaptic maintenance and signaling: terminal bouton organization, active zone cytoskeletal organization, receptor internalization, acetylcholine breakdown in the synaptic cleft, and regulation of excitatory and inhibitory postsynaptic potentials. The retina development term supports neural development context, while osteoblast development may reflect shared protein roles but does not define the cluster. Overall, the cluster appears centered on synaptic structure and neurotransmission.","confidence":"High","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":13},{"id":"GO:0002076","count":12},{"id":"GO:0002087","count":12},{"id":"GO:0072553","count":10},{"id":"GO:2000463","count":10}]},{"hash":"1009539321892145931","title":"Muscle mechanics and cardiac regulation","description":"The top GO terms cluster around mechanotransduction in muscle (cellular response to mechanical stimulus, sarcomere organization, response to muscle stretch) and heart function (regulation of heart rate), indicating a cohesive focus on muscle mechanics and cardiac control, with a few outlier terms related to immune signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0045214","count":2},{"id":"GO:0002027","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0007049","count":2}]},{"hash":"2044023767706169141","title":"Synaptic Transmission and Active Zone Organization","description":"This cluster is dominated by GO terms related to synaptic function: acetylcholine catabolic process in the synaptic cleft, regulation of excitatory and inhibitory postsynaptic potentials, receptor internalization, and cytoskeletal matrix organization at the active zone and presynaptic terminal organization. While there are outlier terms like retina development and osteoblast development, the high representation of postsynaptic regulation, neurotransmitter processing, and active-zone remodeling suggests a cohesive theme around neuronal communication and synapse architecture.","confidence":"High","size":22,"edges":229,"triangles":1501,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":13},{"id":"GO:0002076","count":12},{"id":"GO:0002087","count":12},{"id":"GO:0072553","count":10},{"id":"GO:2000463","count":10}]},{"hash":"1512282925270684190","title":"Prostaglandin-Linked Reproductive Development","description":"This cluster is dominated by prostaglandin biosynthesis terms and multiple reproductive development terms (female genitalia, uterus, female gonad, prostate gland), suggesting a coherent theme around prostaglandin-mediated development and function of reproductive tissues. The presence of other regulatory terms does not override this primary connection. ","confidence":"High","size":22,"edges":41,"triangles":20,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":16},{"id":"GO:0030540","count":15},{"id":"GO:0002677","count":15},{"id":"GO:0060736","count":15},{"id":"GO:0035865","count":15}]},{"hash":"1251973623302069612","title":"Cell cycle progression and DNA replication with RNA modification","description":"The top GO terms cluster around cell cycle control (G1/S transition) and DNA replication, with supporting RNA processing/modification terms (RNA methylation, rRNA modification, transcriptional regulation). This suggests a cohesive theme of coordinating DNA synthesis and RNA metabolism. While there are related xenobiotic and metabolic terms present, the strongest signal is toward cell cycle progression and RNA processing, forming a plausible, specific cluster core.","confidence":"Medium","size":22,"edges":9,"triangles":3,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0042220","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0000082","count":4},{"id":"GO:0035690","count":4},{"id":"GO:0000122","count":4}]},{"hash":"873651904412673057","title":"Stress-Response and Protein Homeostasis","description":"The cluster is enriched for xenobiotic and heat stress responses, autophagy, proteolysis, and post-translational modification (urmylation, deglutamylation), pointing to a core theme of cellular stress adaptation and proteome maintenance; ECM secretion regulation and cell-cycle regulation may be supporting facets.","confidence":"Medium","size":22,"edges":22,"triangles":2,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0003331","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0016236","count":3},{"id":"GO:0051726","count":3}]},{"hash":"2077884574653495311","title":"Inflammation, Coagulation, and Tissue Remodeling","description":"This cluster features immune and coagulation-related GO terms\u2014neutrophil-mediated killing, complement activation, Factor XII activation, and fibrinolysis\u2014together with endothelial barrier regulation and tissue remodeling, suggesting a coordinated inflammatory-vascular remodeling program. The other terms (midbrain development, transcription regulation) are less connected to this theme, but the dominant signals point to inflammation-coagulation-tissue remodeling processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030901","count":11},{"id":"GO:0000122","count":11},{"id":"GO:1903142","count":7},{"id":"GO:0070947","count":7},{"id":"GO:0002542","count":7}]},{"hash":"2188984811309926931","title":"Golgi- and synaptic vesicle trafficking","description":"The top GO terms center on vesicle fusion with the Golgi, endosome-to-Golgi transport, exocytic insertion of neurotransmitter receptors, and spontaneous neurotransmitter secretion, with related cues from Golgi organization and acrosome reaction, indicating a cohesive module of vesicle trafficking and exocytosis, especially in neuronal contexts.","confidence":"High","size":22,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":4},{"id":"GO:0007340","count":4},{"id":"GO:0006675","count":4},{"id":"GO:0033194","count":3},{"id":"GO:2000010","count":3}]},{"hash":"1142463261817911713","title":"Gene Expression and Signaling Regulation","description":"This cluster's terms cluster around regulatory processes: positive regulation of GTPase activity and cellular response to TGF-beta point to signaling control; DNA-templated transcription and RNA guanine-N7-methylation reflect gene expression regulation; protein homooligomerization and promotion of cell proliferation suggest assembly and growth control. While terms like retina development and defense against Gram-positive bacteria appear, they likely reflect broader regulatory networks rather than a single pathway, making the dominant theme regulatory signaling and gene expression.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0035264","count":5},{"id":"GO:0008284","count":5}]},{"hash":"258527365627484936","title":"Epithelial polarity and cytoskeleton organization","description":"The cluster includes terms tightly linked to epithelial cell architecture, such as establishment of epithelial cell apical/basal polarity, bicellular tight junction assembly, microvillus assembly, and actin cytoskeleton organization, along with centrosome localization. Together these point to a cohesive role in organizing epithelial cell polarity and cytoskeletal/junctional structure, with other terms appearing as less central associations.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032443","count":2},{"id":"GO:0070433","count":2},{"id":"GO:0051660","count":2},{"id":"GO:0030033","count":2},{"id":"GO:0008285","count":2}]},{"hash":"1466480238673052574","title":"Unknown","description":"The terms point to a mix of developmental processes (embryonic digestive tract development, anterior lateral line development), signaling pathways (Wnt signaling, vitamin D response), metabolism (insulin processing), stress responses (response to heat), and telomere-related activities. There isn\u2019t a single cohesive function or pathway that unites these terms, so a concise, specific label is not supported by the data.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0030070","count":4},{"id":"GO:0048566","count":4},{"id":"GO:0048899","count":4},{"id":"GO:0070198","count":3}]},{"hash":"597694581981798286","title":"Cytoskeleton Organization and Cell Adhesion","description":"The cluster is dominated by GO terms tied to cytoskeletal structure and cell-matrix interactions (actin crosslinking, microtubule organization, sarcomere organization, focal adhesion assembly, cell adhesion), pointing to a cohesive theme of cytoskeletal dynamics and adhesion. Some terms related to signaling or broader processes (IL-2 production, axon extension) are present but do not override the central cytoskeletal/adhesion focus.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0045214","count":1},{"id":"GO:1900042","count":1},{"id":"GO:0000743","count":1}]},{"hash":"1030019698294813103","title":"Developmental Signaling and Morphogenesis","description":"The top GO terms cluster around developmental and morphogenetic processes (axial mesoderm formation, optic nerve morphogenesis, endothelial proliferation) and associated signaling (ERK cascade) with additional related terms like neuronal synaptic plasticity, suggesting a theme of developmental signaling guiding morphogenesis, despite some general cellular processes also appearing.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0048320","count":1}]},{"hash":"1733325039735456604","title":"Cerebellar Neuron Development and Signaling","description":"The cluster shows enrichment in neural development and signaling terms, especially cerebellar granule cell differentiation, Wnt signaling, and cell migration, supported by broader intracellular signaling and behavioral context; a few terms are more general or immune-related but still tie to signaling processes in neural contexts.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0048549","count":3},{"id":"GO:0007205","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0016055","count":3}]},{"hash":"118603039731643887","title":"Unknown","description":"The GO terms span divergent areas\u2014odontogenesis, neurogenesis, visual perception, apoptosis, immune cytokine regulation (IL-1/IL-8), ubiquitination, and xenobiotic/pH responses\u2014showing no single shared function or pathway across the 22 proteins, and the cluster has no connecting edges, suggesting it does not reflect a cohesive biological process.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042475","count":2},{"id":"GO:0022008","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0006915","count":2}]},{"hash":"75549461898568206","title":"Rho-GTPase signaling and cytoskeletal regulation","description":"This cluster centers on Rho-related signal transduction and GTPase activation, with roles in cytoskeletal organization (microvillus assembly) and neural-related signaling (cerebellar granule cell differentiation and NMDA receptor activity). While there are some terms tied to lens development, endothelial barriers, and other processes, the core appears to be Rho/GTPase\u2013driven signaling intersecting cytoskeletal dynamics and neural signaling. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0021707","count":5},{"id":"GO:0043278","count":3},{"id":"GO:0030033","count":3},{"id":"GO:2000310","count":3}]},{"hash":"1697298032052425536","title":"RNA processing and gene expression regulation","description":"This cluster is dominated by terms tied to RNA processing and transcription control, including positive regulation of mRNA splicing via spliceosome, regulatory ncRNA\u2013mediated gene silencing, and regulation of RNA polymerase II CTD phosphorylation, suggesting a cohesive theme around RNA processing and gene expression. Some viral-host interaction terms and lipid droplet organization appear as broader cellular contexts, but the core signal is RNA processing/gene expression regulation.","confidence":"Medium","size":21,"edges":132,"triangles":437,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":11},{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:0006378","count":8},{"id":"GO:2000276","count":7}]},{"hash":"2118926106593213226","title":"Embryonic transcriptional regulation and organ morphogenesis","description":"This cluster combines GO terms for RNA polymerase II\u2013mediated transcription control (negative/positive regulation, and DNA-templated transcription) with morphogenetic processes across multiple embryonic tissues (neural crest migration, left-right patterning, pancreatic development, lung and ureteric bud branching, digestive tract morphogenesis). The shared theme is developmental regulation of organ formation by transcriptional control.","confidence":"High","size":21,"edges":207,"triangles":1275,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0031018","count":11},{"id":"GO:0090190","count":9},{"id":"GO:0001755","count":9},{"id":"GO:0048557","count":9}]},{"hash":"977262510917443654","title":"Carbohydrate catabolism and sugar-phosphate biosynthesis","description":"GO terms show strong enrichment for sugar metabolism, including tagatose-6-phosphate\u2013 and lactose catabolic pathways, glycolysis via fructose-6-phosphate, carbohydrate phosphorylation, and nucleotide-sugar biosynthesis (e.g., ADP-L-glycero-beta-D-manno-heptose). Despite one obsolete term, the dominant theme is carbohydrate degradation and sugar-phosphate metabolism, justifying this label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0010447","count":2},{"id":"GO:0044209","count":2},{"id":"GO:0061615","count":2},{"id":"GO:1902777","count":2}]},{"hash":"1454750973768183201","title":"Unknown","description":"The GO terms span a wide range of unrelated processes, including retinol/retinal metabolism, pigment biosynthesis (melanin), antibiotic biosynthesis, PHB biosynthesis, oxidation\u2013reduction, sporulation, transcription regulation, and even lung development. There isn\u2019t a clear, single pathway or function tying these terms together across the proteins, suggesting a heterogeneous or cross-species collection rather than a coherent cluster. Confidence: None","confidence":"","size":21,"edges":71,"triangles":120,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0042572","count":9},{"id":"GO:0017000","count":8},{"id":"GO:0042574","count":8},{"id":"GO:0045150","count":7}]},{"hash":"1193836111474430535","title":"Proviral Integration and Latency","description":"The cluster centers on retroviral-like processes: RNA-templated DNA synthesis, DNA integration, and establishment of integrated proviral latency, along with DNA recombination. Additional terms point to viral entry and host-pathogen interactions (viral penetration into the nucleus, symbiont entry, apoptosis activation, RNAi regulation). Taken together, these functions suggest a theme of proviral integration and latent infection with host manipulation. ","confidence":"High","size":21,"edges":15,"triangles":6,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0071320","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0006310","count":3}]},{"hash":"1702254174214004030","title":"Unknown","description":"This cluster shows a mix of functions across muscle physiology (calcium-regulated contraction, muscle attachment), neural development (olfactory nerve organization, neuron apoptotic regulation), hematopoietic development (megakaryocyte development), transcription, meiosis-related differentiation, and general signaling (glucocorticoid signaling, small GTPase signaling). There isn't a clear, single biological theme tying these terms together, so a cohesive label is not evident. ","confidence":"","size":21,"edges":17,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0014809","count":2},{"id":"GO:0016203","count":2},{"id":"GO:0021629","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1475310395215276443","title":"Developmental transcriptional regulation","description":"This cluster is enriched for developmental processes (multicellular organism development and gastrulation) and for gene expression control (DNA-templated transcription, mRNA transport). The presence of transcriptional regulation and signaling terms (positive regulation of GTPase activity, protein autophosphorylation) suggests regulatory networks driving development. Some terms like aging and histone deacetylation are peripheral, but the dominant pattern aligns with developmental gene regulation.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007568","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0043547","count":3}]},{"hash":"2085561758119075727","title":"Embryonic development and organ morphogenesis","description":"Most GO terms point to developmental processes across tissues (pancreatic/endocrine development, left-right patterning, cartilage morphogenesis, placental/trophoblast differentiation, endocardial cushion formation, and overall multicellular organism growth). This suggests a cohesive theme of embryogenesis and tissue morphogenesis for the cluster, with the spliceosome-related term possibly reflecting broader gene regulation rather than a core function. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0000398","count":7},{"id":"GO:0003323","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060806","count":5}]},{"hash":"1967383756174575612","title":"Developmental signaling and cytoskeletal control","description":"These proteins appear enriched in regulatory phosphorylation and signaling (positive regulation of serine/threonine kinase activity, GPCR-related signaling, autophosphorylation, GTPase regulation) and in components linked to actin remodeling (Arp2/3 complex-mediated actin nucleation). Coupled with growth/development terms (multicellular organism growth, skin development) and cell-cycle processes (mitotic cell cycle, mRNA transport, histone acetylation), the cluster seems to coordinate signal transduction with cytoskeletal dynamics and gene expression during development and cell division. The common theme is signaling-driven control of the cytoskeleton and growth programs.","confidence":"Medium","size":21,"edges":27,"triangles":16,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071902","count":6},{"id":"GO:0007205","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0031954","count":6},{"id":"GO:0051028","count":5}]},{"hash":"337220992310060760","title":"Actin Cytoskeleton Remodeling and Neurite Morphogenesis","description":"These proteins cluster around actin cytoskeleton dynamics, with terms for actin filament organization, lamellipodium assembly/morphogenesis, and ruffle formation, indicating roles in cell motility and shape changes. They also include neuron-related processes such as neuron projection development and dendritic spine morphogenesis, suggesting a shared theme of actin-driven remodeling in neuronal structures, with broader applicability to other cell types like megakaryocytes. ","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007015","count":2},{"id":"GO:1900029","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0072673","count":2}]},{"hash":"70910699972185126","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071364","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0072553","count":1},{"id":"GO:1904744","count":1},{"id":"GO:2000288","count":1}]},{"hash":"2006403118539647084","title":"DNA Repair and ERAD/Ubiquitination","description":"This cluster centers on DNA replication and DNA damage repair processes (replication, nucleotide-excision repair, intra-S checkpoint signaling, meiotic cell cycle), with additional ER-associated degradation (ERAD) and ubiquitin-related activities (deglycosylation, deubiquitination, ERAD-related pathways). The GO terms suggest a theme that ties genome maintenance to ER protein quality control and ubiquitin signaling, justifying a combined label. ","confidence":"Medium","size":21,"edges":6,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006517","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0031573","count":4},{"id":"GO:0051321","count":4}]},{"hash":"887459735735657861","title":"Mitotic cell cycle and ER-Golgi trafficking","description":"This cluster centers on cell division and mitotic processes (cell division, mitotic cell cycle, mitotic sister chromatid segregation) and also includes vesicle trafficking between the ER and Golgi, suggesting coordinated intracellular transport essential for mitosis. Additional terms related to growth, cell proliferation, cadherin-mediated adhesion regulation, and wound healing indicate broader roles in tissue remodeling and cell migration, tying cell-cycle progression to extracellular adhesion and signaling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0000070","count":2}]},{"hash":"2156012528420474153","title":"Vertebrate embryonic neural development and patterning","description":"The top GO terms center on neural development (forebrain, neural tube closure, retinal axon guidance) and broad embryonic patterning (anterior/posterior specification, heart and multicellular development), with reinforcing roles for Wnt signaling and Rho-mediated pathways. This combination suggests a cluster tied to vertebrate embryogenesis with emphasis on neural patterning and organogenesis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0030900","count":3},{"id":"GO:0009952","count":3},{"id":"GO:0031290","count":3}]},{"hash":"312756295028268690","title":"Embryonic morphogenesis and organ development","description":"The top GO terms emphasize embryonic tissue differentiation and morphogenesis, including endocardial EMT, cartilage and left-right patterning, placental and pancreatic development. Some general processes like mRNA splicing and COPII cargo loading appear, but the dominant signal is embryonic morphogenesis and organ formation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3}]},{"hash":"1535344717159476309","title":"Unknown","description":"The GO terms for this cluster cover a highly diverse set of processes (vitamin D response, mRNA processing, protein dephosphorylation, cardiac action potential regulation, fat cell differentiation, NF-kappaB/NOD2 signaling, Notch signaling, meiotic recombination, and broad multicellular processes), with no single unifying function or pathway. This heterogeneity makes it unclear to assign a coherent, specific label, so the cluster is best described as Unknown.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":8},{"id":"GO:0006397","count":7},{"id":"GO:0006470","count":7},{"id":"GO:0098907","count":7},{"id":"GO:0045444","count":7}]},{"hash":"1685045258766004476","title":"Lipid transport and fatty acid metabolism","description":"The top GO terms cluster around fatty acid handling: long-chain and medium-chain fatty acid import/transport into cells, long-chain fatty acid metabolic processes, and carnitine metabolic process, indicating coordinated lipid uptake and metabolism. Some terms like lipoteichoic acid biosynthesis and plant-related biosynthetic processes appear peripheral, but the central theme is lipid transport and fatty acid catabolism/usage.","confidence":"Medium","size":21,"edges":11,"triangles":0,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:1902987","count":11},{"id":"GO:0070395","count":9},{"id":"GO:0009718","count":8},{"id":"GO:0015911","count":6},{"id":"GO:0090410","count":6}]},{"hash":"2147001830488856873","title":"Retroviral DNA Integration and Proviral Latency","description":"The top GO terms point to viral DNA integration and establishment of proviral latency (DNA integration, integrated proviral latency) and nuclear import (NLS-bearing proteins import into nucleus), which together suggest a retroviral life cycle stage involving integration and latency with host interactions. Some terms also reflect broad host immune and signaling responses that can accompany viral infection, supporting a cohesive theme centered on retroviral DNA integration and latency, with related host-process modulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0014898","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1097943468589494750","title":"Endothelial development and coagulation-innate immunity","description":"Most prominent signals describe endothelial barrier establishment, tissue remodeling, and coagulation/fibrinolysis (plasminogen activation, fibrinolysis, Factor XII activation), plus neutrophil-mediated antimicrobial activities. These point to a module focused on vascular development and thromboinflammatory remodeling, with additional developmental regulation signals. Medium","confidence":"","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0035264","count":5},{"id":"GO:0010756","count":5},{"id":"GO:0030901","count":5},{"id":"GO:1903142","count":4}]},{"hash":"388510049448764810","title":"Insect larval cuticle development and developmental signaling","description":"The cluster prominently features larval chitin-based cuticle development, with additional terms tied to developmental regulation (Wnt signaling, TGF-beta receptor signaling) and neuron differentiation, suggesting a broader developmental program in larvae that integrates structural formation with signaling pathways. The terms are diverse, but center on development rather than a single enzymatic function, supporting a label focused on insect larval cuticle formation and related signaling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:2000146","count":1},{"id":"GO:0090263","count":1},{"id":"GO:0032480","count":1},{"id":"GO:0000413","count":1}]},{"hash":"1330411411206978253","title":"Unknown","description":"The proteins map to a highly diverse set of GO terms including transport (vitamin and xenobiotic), RNA processing (mRNA splicing, tRNA methylation), post-translational modification (ubiquitination), cilium assembly, cell signaling (peptidyl-tyrosine phosphorylation), immune defense, and cholesterol transport. This broad mix lacks a single cohesive function or pathway that ties most members together, so a specific, meaningful cluster label cannot be inferred.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0050679","count":2},{"id":"GO:0060271","count":2}]},{"hash":"162862278984876941","title":"Embryonic organogenesis and neural/muscle development","description":"This cluster centers on diverse embryonic development processes: eye morphogenesis, peripheral nervous system neuron development, motor neuron axon guidance, limb and skeletal muscle formation, and primitive streak formation, alongside regulation of transcription. The proteins likely participate in broad developmental patterning and organogenesis across multiple tissues, rather than a single tissue-specific function.","confidence":"Medium","size":21,"edges":28,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0048935","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0007519","count":9},{"id":"GO:0090009","count":9}]},{"hash":"1480546854460655533","title":"Immune activation and cell motility","description":"The top GO terms cluster around phagocytosis and adaptive immune response, with dendritic cell chemotaxis and actin-based protrusion assembly (lamellipodium/filopodium), pointing to immune cell activation coupled with migration/motility. While some terms (EGFR signaling, growth hormone regulation) are present, the dominant signal is immune-related function and cytoskeletal dynamics, so the label emphasizes those themes. The isolated network (edges/triangles = 0) does not alter the functional interpretation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006909","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0035176","count":3},{"id":"GO:0007173","count":3},{"id":"GO:0043552","count":3}]},{"hash":"503077834090530403","title":"Unknown","description":"The Top Terms are extremely diverse, including defense against Gram-positive bacteria, multicellular growth, actin nucleation via Arp2/3, invasive growth under glucose limitation, fertilization, histone H3 acetylation, mitotic spindle assembly, GPCR-PLC signaling, transcriptional regulation, and PI3K signaling. With no shared, cohesive function or pathway and zero edges among proteins, there isn\u2019t a single interpretable theme linking them, so an Unknown label is most appropriate.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0035264","count":2},{"id":"GO:2000601","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0007338","count":2}]},{"hash":"761672235945397173","title":"Innate Immune Response with Coagulation and Remodeling","description":"The top GO terms cluster around innate immune activation (response to lipopolysaccharide; neutrophil-mediated killing of fungi/bacteria) alongside coagulation and fibrinolysis (Factor XII activation; fibrinolysis) and vascular/tissue remodeling (endothelial barrier establishment; tissue remodeling). This suggests a cohesive module where inflammation and neutrophil defense are linked to coagulation and remodeling of tissue and vasculature. Some unrelated terms (e.g., midbrain development) may reflect broader regulatory roles of some proteins but do not override the dominant inflammatory-coagulation theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0032496","count":9},{"id":"GO:0030901","count":9},{"id":"GO:1903142","count":8},{"id":"GO:0070947","count":8}]},{"hash":"703418751718706319","title":"Embryonic Development and Organ Morphogenesis","description":"The top GO terms span pancreas development, heart and placenta-related morphogenesis, cartilage and hair follicle formation, and left-right patterning, pointing to a broad theme of embryonic development and tissue morphogenesis across multiple organs rather than a single pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060707","count":4}]},{"hash":"1041604062763808466","title":"Brain development and neuronal signaling","description":"The top GO terms center on brain development and regulation of neuronal activity (e.g., negative regulation of excitatory postsynaptic potential) with supporting signaling pathways such as androgen receptor signaling and JNK cascade, plus processes related to cell adhesion and organelle coupling that can influence neural differentiation and synaptic function. While some terms like ossification or cellular fusion are peripheral, the dominant pattern points to neural development and signaling modulation. ","confidence":"Medium","size":20,"edges":82,"triangles":136,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090394","count":14},{"id":"GO:0033144","count":14},{"id":"GO:1900026","count":14},{"id":"GO:1903206","count":14},{"id":"GO:0007420","count":14}]},{"hash":"1392833253846662011","title":"Signaling and transcription regulation cluster","description":"The GO terms cluster around several major signaling pathways (Wnt, Hippo, JNK, T cell receptor) and transcriptional processes (DNA replication, DNA-templated transcription), with related outcomes such as keratinocyte differentiation, apoptosis, and chemotaxis, suggesting a cohesive role in transducing signals to gene expression and cell fate decisions across development and immunity.","confidence":"Medium","size":20,"edges":12,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090263","count":9},{"id":"GO:0050852","count":8},{"id":"GO:0006260","count":8},{"id":"GO:0006915","count":8},{"id":"GO:0006351","count":8}]},{"hash":"1864876018926133562","title":"RNA processing and translation initiation","description":"Dominant GO terms center on mRNA splicing via spliceosome and translation initiation (translation reinitiation, formation of translation preinitiation complex), with additional, more general terms for cell cycle and development, suggesting a cluster of RNA processing and translation machinery rather than a single pathway.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0030900","count":4},{"id":"GO:0001843","count":4}]},{"hash":"1096238058442536007","title":"Autonomic Cardiovascular GPCR Signaling","description":"This cluster centrally links GPCR-mediated signal transduction to cardiovascular regulation, including positive regulation of blood pressure, heart-rate modulation by adrenergic signals, adenylate cyclase activation, and smooth muscle relaxation. While metabolism-related terms like electron transport appear, the dominant pattern is autonomic cardiovascular control via GPCR pathways. Some terms about feeding and grooming hint at broader neuromodulatory roles but do not override the main theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":8},{"id":"GO:0010579","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0007190","count":7},{"id":"GO:0071805","count":7}]},{"hash":"1849854948876919210","title":"NFAT-Driven EMT and Tissue Remodeling","description":"The terms cluster around developmental tissue remodeling, including EMT, lymphangiogenesis, and neural/Schwann cell development, with regulation through the calcineurin-NFAT pathway, suggesting a shared signaling module across tissues.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001837","count":5},{"id":"GO:0001946","count":4},{"id":"GO:0050774","count":4},{"id":"GO:0014898","count":4},{"id":"GO:0051343","count":4}]},{"hash":"1754522353718453038","title":"Craniofacial skeletal and neural development","description":"The top GO terms point to development of craniofacial structures (osteoblast development, embryonic cranial skeleton morphogenesis, odontogenesis) and neural-related tissues (midbrain, retina, subthalamic nucleus, pituitary). A broad transcriptional regulatory component ties these developmental processes together, suggesting a coherent theme of coordinated growth of craniofacial bones/teeth with neural tissues. ","confidence":"Medium","size":20,"edges":9,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":10},{"id":"GO:0048701","count":9},{"id":"GO:0002076","count":9},{"id":"GO:0021983","count":9}]},{"hash":"1825209353498350218","title":"Membrane Trafficking and Vesicle Transport","description":"The top GO terms cluster around vesicle and membrane trafficking (endosome-to-melanosome transport, phagosome maturation, Golgi-to-plasma membrane transport) and include vesicle exocytosis and membrane-associated adhesion, suggesting a coherent function in membrane dynamics and vesicle movement. Some terms are broader or tissue-specific, but the dominant signal is intracellular transport and membrane organization.","confidence":"High","size":20,"edges":7,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090136","count":5},{"id":"GO:2000300","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0060047","count":4},{"id":"GO:0050771","count":4}]},{"hash":"1827593135876597279","title":"Embryonic development and organogenesis","description":"The dominant GO terms describe developmental and differentiation processes across multiple tissues and organs\u2014cartilage morphogenesis, endocrine and pancreatic cell development, placenta and trophoblast differentiation, heart-related morphogenesis (endocardial cushion/EMT), and left-right patterning\u2014pointing to a cohesive theme of embryonic development and organ formation. The additional terms about RNA splicing and ribosomal export reflect core cellular machinery that underpins these developmental programs. ","confidence":"High","size":20,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:1903026","count":4},{"id":"GO:0003323","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1794887964966585555","title":"RNA Polymerase II/III Transcription Machinery","description":"The top GO terms concentrate on transcription initiation and assembly of RNA polymerase II and III preinitiation complexes, plus DNA-templated transcription, indicating proteins involved in transcription machinery. A few terms pertain to meiosis and mammary gland development, which may be incidental annotations rather than core cluster functions. Overall, the theme is transcription initiation/regulation. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0007129","count":2},{"id":"GO:0070898","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0070893","count":1}]},{"hash":"1238803039698336016","title":"Cell signaling and gene expression regulation","description":"The proteins show enrichment for signaling pathway regulation (potassium transport, GPCR signaling, GTPase activity, adenylate cyclase regulation) together with transcription and mRNA splicing terms, plus development and cytoskeletal-related processes (spinal cord development, sarcomere organization, mitotic spindle assembly). This suggests a cohesive theme around signaling control that modulates gene expression and related processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0045214","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045762","count":2},{"id":"GO:0000398","count":2}]},{"hash":"2027296189580337828","title":"LPS core and O-antigen biosynthesis","description":"The cluster is strongly enriched for lipopolysaccharide biosynthetic processes, including core region and O-antigen synthesis, and related heptose biosynthesis, indicating a focus on bacterial LPS assembly. Other carbohydrate metabolism terms support polysaccharide envelope construction, with some seemingly unrelated annotations (e.g., plant secondary metabolite terms) likely representing annotation noise. Overall, the dominant theme is bacterial LPS and envelope polysaccharide biosynthesis.","confidence":"High","size":20,"edges":83,"triangles":160,"max_degree":16,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":13},{"id":"GO:0017000","count":12},{"id":"GO:0009103","count":9},{"id":"GO:0055114","count":8},{"id":"GO:0097171","count":8}]},{"hash":"1483249996702585361","title":"Prostaglandin biosynthesis and female reproductive development","description":"The top GO terms cluster around prostaglandin biosynthesis and female reproductive development (female genitalia, uterus, and female gonad development), suggesting a prostaglandin-mediated role in reproductive tissue development. While other terms (immune regulation, potassium ion response) appear, they are less central to the dominant theme of prostaglandin-associated reproductive processes. ","confidence":"Medium","size":20,"edges":23,"triangles":12,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":7},{"id":"GO:0030540","count":5},{"id":"GO:0002677","count":5},{"id":"GO:0060736","count":5},{"id":"GO:0035865","count":5}]},{"hash":"1515992698776510291","title":"Innate Immune Signaling and Cytoskeleton","description":"The set is enriched for innate immune pathways (innate immune response, Toll signaling, NF-kappaB) and immunoreceptor signaling (Fc-epsilon receptor), with a concurrent signal for actin filament organization and GTPase regulation, suggesting a theme of immune signaling linked to cytoskeletal dynamics; a couple of development terms appear but are less central.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0038095","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0033146","count":2},{"id":"GO:0006469","count":2}]},{"hash":"1590813116417949337","title":"Vascular ECM Remodeling and Coagulation","description":"The GO terms indicate strong emphasis on coagulation and fibrinolysis (blood coagulation; regulatory effects on fibrinolysis), together with extracellular matrix components and vessel-associated processes (collagen fibril organization, vascular smooth muscle proliferation, mechanical stimulus response). This points to extracellular matrix remodeling in blood vessels and coordinated signaling for coagulation and vascular development, with additional developmental links to organ systems like kidney. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein maturation","top_go_terms":[{"id":"GO:0051918","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0007596","count":4},{"id":"GO:1902042","count":4},{"id":"GO:1904707","count":4}]},{"hash":"2236474192103089604","title":"Neuroimmune and metabolic signaling cluster","description":"The GO terms span neural signaling (neuropeptide signaling, behavioral response to starvation), metabolism (carbohydrate metabolic process), immune antigen presentation (MHC I and II), and growth regulation (angiogenesis, fibroblast proliferation). This broad mix suggests multiple, cross-cutting pathways rather than a single cohesive function, so the label reflects a broad neuroimmune-metabolic signaling theme with modest confidence.","confidence":"Low","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":2},{"id":"GO:0048659","count":2},{"id":"GO:0030308","count":2},{"id":"GO:0045766","count":2},{"id":"GO:2001238","count":2}]},{"hash":"638706656301533895","title":"Drosophila development and apoptosis","description":"The terms point to developmental regulation in Drosophila (antennal and eye/photoreceptor development, head segmentation, larval cuticle formation, tracheal epithelial migration) together with apoptosis-related processes and transcriptional regulation. The presence of oskar mRNA translation regulation further anchors the cluster to Drosophila biology, suggesting proteins involved in developmental signaling and programmed cell death. Confidence reflects a coherent but diverse mix of developmental and apoptotic functions in a Drosophila context.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0046011","count":1},{"id":"GO:1902108","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0006915","count":1}]},{"hash":"2153702740712163898","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010793","count":2},{"id":"GO:0006362","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0090239","count":1}]},{"hash":"73262712559658273","title":"Embryonic and Organ Development","description":"The top GO terms cluster around developmental processes across multiple tissues (pancreas development, endocrine system development, cartilage morphogenesis, left-right patterning, trophoblast differentiation, EMT in heart development), suggesting a shared theme of embryogenesis and organogenesis. A couple of terms refer to general cellular machinery (mRNA splicing, ribosomal export), which are broad but do not negate the overarching developmental signal. Overall, the set points to developmental biology across tissues, hence this label with Medium confidence.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":5},{"id":"GO:1903026","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060806","count":4}]},{"hash":"1439180818907862872","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":111,"triangles":338,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":11},{"id":"GO:0048026","count":8},{"id":"GO:0031047","count":8},{"id":"GO:0000463","count":7},{"id":"GO:0071042","count":7}]},{"hash":"1041105679369748945","title":"Translation initiation and mRNA processing regulation","description":"These proteins are linked by roles in post-transcriptional gene expression, notably initiation of translation (formation of the preinitiation complex, translation reinitiation, IRES-dependent initiation, and regulation of initiation) and mRNA processing steps (splicing, splice-site recognition, and poly(A) tail regulation). The co-occurrence of these GO terms suggests a cohesive theme around controlling mRNA maturation and its use for protein synthesis, including viral translation strategies. ","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":8},{"id":"GO:0002188","count":6},{"id":"GO:0075522","count":5},{"id":"GO:0006446","count":5},{"id":"GO:0006378","count":5}]},{"hash":"469847703396399563","title":"RNA processing and translation regulation","description":"The top GO terms show strong enrichment for mRNA processing and splicing (spliceosome-mediated splicing, mRNA cis/splicing, and regulation of alternative splicing) along with mRNA stability and translation initiation/reinitiation. This points to a cluster of proteins involved in post-transcriptional RNA processing and control of translation, rather than a single metabolic or signaling pathway. Some growth-related and cell-cycle terms appear, but the core pattern centers on RNA maturation and translational regulation.","confidence":"High","size":19,"edges":5,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002188","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0000398","count":6},{"id":"GO:0048255","count":5},{"id":"GO:0006378","count":5}]},{"hash":"971029335981056901","title":"Virus life cycle and host interaction","description":"The top GO terms show virion assembly, uncoating, host-mediated activation of viral genome replication, and establishment of integrated proviral latency, plus symbiont entry into host and lipid droplet organization. While some housekeeping processes appear (splicing, ribosome biogenesis), the strongest signal centers on viral entry, assembly, latency, and host-virus interactions, suggesting this cluster reflects viral life cycle processes and host manipulation. This makes the label a good, specific umbrella for the cluster.","confidence":"High","size":19,"edges":11,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0042273","count":3},{"id":"GO:2000276","count":2},{"id":"GO:0000413","count":2},{"id":"GO:0075713","count":2}]},{"hash":"107028366571197297","title":"Mitochondrial fatty acid oxidation and energy metabolism","description":"The cluster is enriched in fatty acid beta-oxidation terms (acyl-CoA dehydrogenase/oxidase, long-chain FA catabolism) and carnitine metabolic processes, plus proton transmembrane transport reflecting the mitochondrial inner membrane. Additional signals for starvation response, unfolded protein response, and regulation of gluconeogenesis point to mitochondrial energy stress adaptation, reinforcing a theme of mitochondrial fatty acid oxidation and energy metabolism.","confidence":"High","size":19,"edges":10,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":4},{"id":"GO:0006626","count":3},{"id":"GO:0042594","count":3},{"id":"GO:0006986","count":2},{"id":"GO:0033539","count":2}]},{"hash":"170925784639110127","title":"mRNA Splicing and Translation Regulation","description":"The top GO terms cluster around spliceosome-mediated mRNA processing (alternative splicing, splice-site recognition, regulation of splicing, small-subunit processome assembly) and mechanisms of translation initiation and reinitiation (IRES-dependent initiation, regulation of translational initiation, translation reinitiation), with additional notes on mRNA stabilization and poly(A) tail regulation. This points to a cohesive group of proteins involved in RNA processing and control of translation, rather than a single straightforward pathway.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":3},{"id":"GO:0048026","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0006376","count":2},{"id":"GO:0060211","count":2}]},{"hash":"80554071131998730","title":"Circadian Transcription Regulators","description":"This cluster is dominated by GO terms tied to transcription and circadian biology: DNA-templated transcription (GO:0006351), circadian regulation of gene expression (GO:0032922), and positive regulation of circadian rhythm (GO:0042753). The strong presence of these terms suggests a group enriched for transcription factors and clock-related gene regulation. Additional terms like corticosterone stimulus response and regulation of glutamate uptake may reflect neural or stress-related links to circadian control, while other terms such as epithelial differentiation and elastin metabolism could reflect broader tissue-specific expression. Overall, the unifying theme is circadian control of transcription. ","confidence":"High","size":19,"edges":126,"triangles":485,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":18},{"id":"GO:0032922","count":17},{"id":"GO:0042753","count":16},{"id":"GO:0043433","count":13},{"id":"GO:1903715","count":11}]},{"hash":"721140137380300450","title":"Insect Development and Cuticle/Eggshell Formation","description":"The prominent GO terms point to insect-specific development, especially larval chitin-based cuticle formation and chorion-containing eggshell formation, suggesting a theme of external barrier and tissue development in insects. Other terms indicate broader multicellular development and differentiation and some regulatory/transport roles, which may accompany developmental programs. Overall, the cluster seems centered on insect development with emphasis on cuticle and eggshell formation, with ancillary regulatory and transport processes. ","confidence":"Medium","size":19,"edges":22,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0006816","count":2},{"id":"GO:0033234","count":2},{"id":"GO:0014718","count":2}]},{"hash":"994443238483570021","title":"Diverse Transmembrane Transport","description":"GO terms show transmembrane transport of a broad range of substrates\u2014xenobiotics, vitamins, sugars, ions, and metabolites\u2014with an additional related role in neurotransmitter loading into synaptic vesicles, indicating a general membrane transport function across multiple substrates rather than a single substrate-specific activity.","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0035461","count":5},{"id":"GO:0015739","count":5},{"id":"GO:0035435","count":5},{"id":"GO:0098700","count":5}]},{"hash":"245798553099364746","title":"Developmental Morphogenesis and Organ Formation","description":"The GO terms center on development and morphogenesis across tissues and organs (insect cuticle and eggshell formation, valve and nephrogenic morphogenesis) and include SMAD signaling; this points to a cohesive theme of developmental regulation rather than a single molecular function.","confidence":"High","size":19,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5},{"id":"GO:0007275","count":2},{"id":"GO:0007304","count":2},{"id":"GO:0002520","count":1},{"id":"GO:0072133","count":1}]},{"hash":"514211598195284621","title":"Central carbon metabolism and nutrient response","description":"The cluster is dominated by GO terms for glycolysis, the TCA cycle, 2-oxoglutarate metabolism, gluconeogenesis, and acetyl-CoA formation from pyruvate, plus leucine catabolism, indicating a cohesive core of energy production and amino-acid breakdown. The inclusion of sodium ion transport and responses to nutrients or xenobiotics suggests broader metabolic regulation and adaptation to environmental cues.","confidence":"High","size":19,"edges":148,"triangles":741,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":11},{"id":"GO:0006096","count":9},{"id":"GO:0006103","count":6},{"id":"GO:0006094","count":5},{"id":"GO:0006552","count":5}]},{"hash":"240360355266186696","title":"Eggshell and larval cuticle development","description":"The top GO terms point to developmental processes shaping extracellular protective layers: chorion-containing eggshell formation and larval chitin-based cuticle development, with multicellular organism development as a broader context. While a few terms reflect general cellular processes (ribosomal export, ubiquitination, heat and mechanical response), the strongest signal is eggshell and cuticle formation during development, likely insect-related. Thus the label captures the core theme without overgeneralizing to unrelated processes. ","confidence":"Medium","size":19,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0007304","count":4},{"id":"GO:0008363","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0009408","count":2}]},{"hash":"1967673532072093001","title":"Developmental Transcription and Differentiation","description":"This cluster centers on transcriptional control (DNA-templated transcription and RNA polymerase II activity) and SMAD signaling, with multiple terms tied to differentiation across tissues (osteoblasts, lens fibers, adipocytes, spinal motor neurons, cardiac muscle), suggesting a shared theme of transcriptional regulation guiding developmental differentiation. A secondary immune-related term (MHC II biosynthesis) is present but less central.","confidence":"High","size":19,"edges":48,"triangles":104,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0060395","count":5},{"id":"GO:0045348","count":5},{"id":"GO:0045669","count":5},{"id":"GO:2000480","count":5}]},{"hash":"116188288950123405","title":"Multi-Substrate Membrane Transporters","description":"Top GO terms consistently describe transmembrane transport of diverse substrates, indicating a cluster of membrane transport proteins with broad specificity.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0015771","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0015747","count":2}]},{"hash":"2166836395042962944","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0031116","count":2},{"id":"GO:0055123","count":2},{"id":"GO:0090239","count":1},{"id":"GO:0032968","count":1}]},{"hash":"1003688000975572033","title":"Fatty acid metabolism and transport","description":"The cluster is dominated by GO terms related to fatty acid metabolism and transport, including medium- and long-chain fatty acids, fatty-acyl-CoA metabolism, and fatty acid import. Additional terms point to related lipid biosynthesis (lipoteichoic acid) and other lipid-associated or central-carbon metabolic processes, suggesting a cohesive theme of lipid handling across the proteins (often seen in bacteria). This makes fatty acid metabolism and transport a concise, representative label.","confidence":"Medium","size":19,"edges":124,"triangles":383,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0036112","count":8},{"id":"GO:0055114","count":7},{"id":"GO:0090410","count":6},{"id":"GO:0010030","count":6},{"id":"GO:0001579","count":6}]},{"hash":"601804180179509051","title":"Steroid Hormone Biosynthesis and Muscle Stress Response","description":"Top GO terms indicate steroid hormone biosynthesis (aldosterone, cortisol) with related metabolic processes, alongside muscle development and stress-induced cardiac hypertrophy, suggesting a theme around steroid production and muscle adaptation. Some terms (xenobiotic response, DNA replication, female genitalia development) are less coherent with this theme, but the dominant signal centers on hormone biosynthesis and muscle stress response.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0033076","count":4},{"id":"GO:0032342","count":4},{"id":"GO:0034651","count":4},{"id":"GO:0035690","count":3},{"id":"GO:0048741","count":3}]},{"hash":"815902852461971207","title":"Eye Development and Embryogenesis","description":"This cluster is enriched for multiple GO terms specifically tied to eye formation: retina development in camera-type eye, camera-type eye development, embryonic eye morphogenesis, and in utero embryonic development. These repeatedly point to ocular development and early embryogenesis as the core theme. Additional terms such as osteoblast development, skeletal muscle tissue development, and pituitary gland development suggest broader developmental programs, but they do not outweigh the dominant eye-related terms. A few regulatory terms (negative regulation of transcription by RNA polymerase II) may reflect general gene expression control during development, but the prevailing signal is eye/embryo development.","confidence":"High","size":19,"edges":78,"triangles":76,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":8},{"id":"GO:0002076","count":8},{"id":"GO:0002087","count":8},{"id":"GO:0042493","count":7},{"id":"GO:0021983","count":7}]},{"hash":"1702733025370067906","title":"Translation machinery and stress-response signaling","description":"The cluster\u2019s top GO terms are dominated by ribosome biogenesis and cytoplasmic translation, pointing to proteins involved in protein synthesis. Additional terms reflect various cellular stress responses (prostaglandin E, ethanol, fungal origin) and signaling pathways (JNK cascade, EGFR), suggesting these proteins may participate in translation-related processes with regulatory/stress-responsive roles. Some broader cell-cycle or DNA-processing terms appear, but the recurring association is with translation machinery and its regulation, supporting a translation-centered cluster with ancillary signaling connections.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":3},{"id":"GO:0071361","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0007099","count":2}]},{"hash":"223458727863276470","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms center on ubiquitin-mediated protein turnover, including SCF-dependent proteasomal degradation, ERAD, autoubiquitination, K48-linked ubiquitination, and neddylation, with additional routes via multivesicular bodies. While some terms touch on repair or viral processes, the dominant signal is ubiquitin-tagged proteolysis and proteasome-mediated degradation. ","confidence":"High","size":19,"edges":37,"triangles":40,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0031146","count":8},{"id":"GO:0030433","count":6},{"id":"GO:0051865","count":6},{"id":"GO:0045116","count":5}]},{"hash":"1697678477968472303","title":"Neural development and sensory signaling","description":"The top terms cluster around neural differentiation (cerebellar granule cell differentiation), visual perception (light detection), startle reflex, and intracellular signaling, with ion transport (Ca, Na, Mn) supporting neuronal activity, pointing to a cohesive theme of neural development and sensory signaling. Some terms (like skin development) are less directly related but may reflect broader developmental signaling overlap.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0050908","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0006828","count":3},{"id":"GO:0098703","count":3}]},{"hash":"1637262386771807834","title":"Unknown","description":"The GO terms are a mix of apoptosis, cell cycle, transcription regulation, lysosome targeting, tissue-specific development, receptor clustering, metabolism, and mitochondrial ribosome assembly, with no single dominant process. This diversity makes it unclear what common function defines the cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0007076","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006622","count":2}]},{"hash":"693058442922417780","title":"Embryonic Development and Organ Morphogenesis","description":"This cluster is dominated by GO terms tied to embryonic development and organ formation, including type B pancreatic cell development, EMT in heart/endochamber formation, cartilage morphogenesis, placenta-related differentiation, trophoblast differentiation, endocrine system development, and left-right patterning. The presence of a transcriptional regulatory term suggests developmental gene regulation. A couple of biosynthetic terms appear incidental to the main developmental theme. Overall, the proteins cluster around embryonic developmental programs and tissue morphogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060707","count":4}]},{"hash":"1491961926019239073","title":"Developmental growth and actin cytoskeleton remodeling","description":"The cluster is enriched for terms tied to multicellular development and growth, alongside cell division and mitotic processes, with notable regulation of GTPase activity and Arp2/3-mediated actin nucleation. This points to a group of proteins coordinating development, proliferation, and actin dynamics during cellular remodeling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0043547","count":3},{"id":"GO:2000601","count":2},{"id":"GO:0042595","count":2},{"id":"GO:0035264","count":2}]},{"hash":"2281777433676898667","title":"Immune response and proteostasis","description":"The terms are dominated by immune-related processes: complement activation (classical pathway) and positive regulation of antigen processing and presentation via MHC II, along with proteostasis signals from ubiquitination and SCF-dependent proteasomal degradation. Some terms about neuron projection development and atrial cardiac muscle cell action potential appear as outliers, suggesting additional tissue-specific annotations but not a unifying theme for the entire cluster. Overall, the cluster seems to be driven by immune processing and protein turnover.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0086014","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0000209","count":2}]},{"hash":"556435637046138011","title":"Innate immune defense and signaling proteins","description":"The top GO terms show a clear enrichment for innate immune response and defense against Gram-positive bacteria, suggesting a core role in immune defense. Related signaling terms (ERK cascade, PI3K/PLC activity) indicate involvement in immune signaling pathways. The presence of heart and skeletal development terms likely reflects broad, pleiotropic annotations rather than a cohesive developmental module, and the absence of edges among proteins implies a dispersed set rather than a tightly connected cluster. Overall, the most representative theme is innate immune defense with associated signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0001501","count":5}]},{"hash":"1383908166598773278","title":"Renal nephron development","description":"These proteins show strong enrichment for kidney development terms, including metanephric ascending thin limb development, mesonephric duct development, and metanephric proximal tubule development, pointing to a renal/urinary system developmental theme. There are additional immune-related terms present, but the renal development annotations appear to be the most representative signal for this cluster.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":4},{"id":"GO:0060355","count":3},{"id":"GO:0072218","count":3},{"id":"GO:0090238","count":3},{"id":"GO:2000502","count":3}]},{"hash":"2228212172167404609","title":"Mitotic and Meiotic Chromosome Segregation","description":"Dominant GO terms point to chromosome segregation and alignment during cell division, across both mitosis and meiosis (sister chromatid segregation, metaphase alignment, meiosis chromosome segregation, meiosis cytokinesis). While a few terms reference signaling or oligomerization that are less central to this theme, the core pattern is cell-division\u2013related chromosomal dynamics.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000070","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0035544","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0007065","count":2}]},{"hash":"1865352358365102498","title":"Mitochondrial translation and Complex IV assembly","description":"The cluster is clearly centered on mitochondrial functions: translation via mitochondrial ribosomes, ribosomal subunit assembly, and assembly of the respiratory chain (notably Complex IV), with supporting processes such as protein import into the mitochondrial matrix and proton-motive force\u2013driven ATP synthesis. A brain development term appears but does not alter the core theme of mitochondrial protein synthesis and oxidative phosphorylation assembly, which this label captures succinctly.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0033617","count":2},{"id":"GO:0000027","count":1},{"id":"GO:0017148","count":1},{"id":"GO:0021762","count":1}]},{"hash":"723026945655162738","title":"Metabolic Pathways with Neuronal Development Signals","description":"This cluster is dominated by a set of metabolic GO terms (glycolytic, cholesterol, methanol/methane, glycerol, glycine betaine biosynthesis, pyridoxine) indicating diverse energy and small-molecule metabolism. A couple of terms relate to development and neuron maturation, but the recurring theme across most terms is metabolism, so the label centers on broad metabolic processes with a minor developmental context.","confidence":"Medium","size":18,"edges":26,"triangles":20,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0015945","count":6},{"id":"GO:0008203","count":6},{"id":"GO:0046188","count":6},{"id":"GO:0019285","count":6}]},{"hash":"195243486237519279","title":"Mitochondrial translation & cristae biogenesis","description":"This cluster is strongly enriched for translation-related terms, including mitochondrial translation, tRNA aminoacylation, and regulation of translational fidelity, along with cristae formation. These together point to mitochondrial ribosome function and inner mitochondrial membrane organization as the core shared theme among the proteins, with auxiliary terms like angiogenesis and symbiont entry likely reflecting broader cellular context rather than a defining function of the cluster.","confidence":"High","size":18,"edges":91,"triangles":240,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0001525","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0070131","count":2},{"id":"GO:0042407","count":2}]},{"hash":"504868211888637325","title":"Detox and Prostaglandin Biosynthesis","description":"The strongest signals are prostaglandin biosynthesis and detoxification-related GO terms (redox homeostasis, oxidant detoxification, xenobiotic and toxin catabolic processes), pointing to a functional module centered on chemical defense and lipid mediator production. Some terms (odor perception, translational elongation, progenitor proliferation) may reflect annotation noise or broader multifunctionality, but the core theme is detoxification coupled with prostaglandin synthesis.","confidence":"High","size":18,"edges":127,"triangles":507,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":15},{"id":"GO:0045454","count":13},{"id":"GO:0098869","count":13},{"id":"GO:0010044","count":12},{"id":"GO:0042178","count":12}]},{"hash":"352453565073741913","title":"Multiorgan Development and Differentiation Regulators","description":"This cluster shows proteins linked to development and differentiation across multiple organs (pituitary, heart, liver, tooth, gonad, etc.), with a transcriptional-regulatory component. The varied GO terms point to a general organogenesis/differentiation role rather than a single pathway, justifying a multisystem development label.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0021983","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0021763","count":1},{"id":"GO:0042663","count":1}]},{"hash":"505300434394259491","title":"Lineage-specific differentiation programs","description":"The cluster is enriched for broad transcriptional activity (RNA polymerase II) and multiple, diverse differentiation processes across lineages\u2014skeletal muscle, myoblast differentiation, melanocytes, arterial/endothelial lineages, and nerve development\u2014plus regulatory terms for promoting or inhibiting differentiation. This points to a set of genes involved in controlling differentiation across several cell types rather than a single pathway, so a high-level label like lineage-specific differentiation is appropriate, though the diversity keeps confidence at a Medium level.","confidence":"Medium","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0035914","count":11},{"id":"GO:0045663","count":10},{"id":"GO:2001016","count":10},{"id":"GO:0030318","count":10}]},{"hash":"88524143185051566","title":"Embryogenesis and Gene Expression Regulation","description":"The cluster's top GO terms include embryonic development processes (endocardial cushion formation, left-right pattern formation, cartilage morphogenesis, endocrine system development, placental differentiation) alongside RNA- and protein-expression machinery (mRNA processing, ribosomal subunit export, ubiquitin-mediated proteolysis, transcriptional regulation of RNA Polymerase II). This combination suggests proteins that coordinate developmental programs with gene expression control.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0042787","count":2}]},{"hash":"1593378772697427990","title":"Retroviral integration and proviral latency","description":"The cluster centers on processes from retroviral life cycles: DNA integration, recombination, and replication, plus RNA-templated DNA synthesis (reverse transcription) and establishment of integrated proviral latency. Additional GO terms point to viral entry into the host nucleus and later host interactions (e.g., activation of host apoptosis and modulation of RNA silencing), suggesting a cohesive theme of retroviral/proviral activity and host manipulation. Together, these terms strongly indicate a module focused on proviral integration and latent infection.","confidence":"High","size":18,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006284","count":2},{"id":"GO:0075713","count":2}]},{"hash":"643299882948185947","title":"Growth Factor Receptor Signaling and MAPK Pathways","description":"The top terms point to receptor-mediated signaling driven by growth factors: EGFR signaling, FGF receptor signaling, and a serine/threonine kinase receptor pathway, with downstream JNK/MAPK cascade involvement and responses to growth factor stimuli. While there are a few unrelated terms (e.g., centriole replication, cholesterol biosynthesis), the dominant theme is growth factor receptor signaling and MAP kinase\u2013mediated responses.","confidence":"Medium","size":18,"edges":93,"triangles":266,"max_degree":16,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007099","count":17},{"id":"GO:0035607","count":17},{"id":"GO:0000706","count":17},{"id":"GO:0071226","count":17},{"id":"GO:0046330","count":17}]},{"hash":"173171580777390175","title":"Neuronal signaling and synaptic plasticity","description":"This cluster is dominated by GO terms related to neural communication and plasticity, including positive regulation of glutamatergic synaptic transmission, positive regulation of synapse structural plasticity, and sensory perception of sound, as well as social behavior. While a few outlier terms (osmotic stress, nitrate assimilation, barrier function, T cell proliferation) are present, the core signal points to neuronal signaling and synaptic modification as the shared theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0006970","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0090557","count":2},{"id":"GO:0048170","count":2}]},{"hash":"1384746980336765814","title":"Broad Stress Response Signaling","description":"The GO terms cluster around responses to xenobiotic stimuli, hypoxia, and heat, plus various GPCR signaling pathways and stress-related biosynthetic/remodeling processes. The common theme is cellular adaptation to diverse stresses via signaling and metabolic adjustments, suggesting a broad stress-response signaling cluster across possible organisms.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0001666","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0016998","count":2},{"id":"GO:0071880","count":2}]},{"hash":"1237968668145488222","title":"Sodium and potassium ion transport and homeostasis","description":"The top GO terms center on sodium/potassium transport across the plasma membrane, their export/import, and intracellular potassium homeostasis, plus related processes like proton transport and cell volume regulation, and salt-stress response. These together indicate a cohesive focus on ion transport and ionic/osmotic balance. Some terms (BDNF receptor signaling, cardiac conduction) may reflect broader roles of ion-related signaling proteins but do not outweigh the central theme. Overall, this cluster likely represents proteins involved in ion transport and homeostasis.","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097623","count":4},{"id":"GO:0030007","count":4},{"id":"GO:0098719","count":4},{"id":"GO:0009651","count":3},{"id":"GO:0031547","count":3}]},{"hash":"721873997387705977","title":"Diverse Biosynthesis and Metabolism","description":"The top GO terms point to a mix of biosynthetic and metabolic processes across various systems (antibiotic biosynthesis, retinol, melanin, poly-hydroxybutyrate, acetoin, 3-keto-sphinganine metabolism) plus redox activity and some regulatory/developmental or drug-response terms. This suggests proteins involved in multiple, diverse metabolic pathways rather than a single unified function. A concise, high-level label capturing this heterogeneity is \u201cDiverse Biosynthesis and Metabolism.\u201d","confidence":"Medium","size":18,"edges":37,"triangles":26,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0017000","count":13},{"id":"GO:0042572","count":13},{"id":"GO:0045150","count":12},{"id":"GO:0042619","count":12}]},{"hash":"1608454304493031522","title":"Neural development and synaptic regulation","description":"The GO terms are dominated by brain-related development (amygdala development, adrenal gland development, hair follicle maturation in some contexts) and by synaptic function/regulation (regulation of long-term synaptic potentiation, negative regulation of neurotransmitter secretion). There are also signals of neural stress/detox (glutathione catabolic process, response to toxic substance) and membrane lipid biosynthesis (phosphatidylcholine), which can relate to neural signaling. Overall, the cluster appears to be centered on neural development and modulation of synaptic activity, with ancillary detox/oxidative stress aspects.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006751","count":2},{"id":"GO:1900271","count":2},{"id":"GO:0090212","count":2},{"id":"GO:0030325","count":2},{"id":"GO:0048820","count":2}]},{"hash":"994181288320468095","title":"Mitotic control and ubiquitin-dependent proteostasis","description":"Several top GO terms point to mitosis and cell-cycle regulation (mitotic cell cycle; anaphase-promoting complex-dependent catabolic process) and centromere/chromatin maintenance (CENP-A containing chromatin assembly). Additionally, ubiquitin-related processes (K11-linked ubiquitination; ubiquitin-dependent ERAD pathway) and ER-Golgi trafficking appear, suggesting coordinated proteostasis and protein turnover during cell division. While some terms (splicing, ERAD) extend beyond strict mitosis, the dominant theme across the cluster is mitotic control linked with ubiquitin-mediated regulation and chromatin maintenance.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0006888","count":6},{"id":"GO:0071276","count":6},{"id":"GO:0031145","count":5},{"id":"GO:0000278","count":5}]},{"hash":"2238534103810460351","title":"Telomere maintenance and ADP-ribosylation","description":"The top GO terms cluster around telomere biology\u2014localization to telomeric regions and regulation of telomere maintenance (both positive and negative)\u2014and chromatin-associated ADP-ribosylation processes (poly- and auto-ADP-ribosylation). This suggests a shared theme of telomere dynamics and chromatin modification, despite the presence of some other signaling terms.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0016055","count":5},{"id":"GO:0070198","count":4},{"id":"GO:0070212","count":4}]},{"hash":"1959629310489778691","title":"Unknown","description":"The GO terms are highly heterogeneous and include transcription regulation, chromatin modification, immune signaling, plant hormone biosynthesis, and even obsolete terms, with no clear shared function across the 18 proteins. Because there is no cohesive biological theme tying these terms together, a specific, representative label cannot be assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051974","count":1},{"id":"GO:0034244","count":1},{"id":"GO:0007249","count":1},{"id":"GO:0090055","count":1},{"id":"GO:0009688","count":1}]},{"hash":"2140161541373900502","title":"Cytoskeleton remodeling and cell migration signaling","description":"The Top Terms point to cytoskeletal dynamics and motility: Rho signaling, podosome assembly, negative regulation of cell adhesion, and migration-related processes in smooth muscle cells. While other terms touch insulin/IGF stimulus, chemokine production, or apoptotic signaling, the recurring themes emphasize cytoskeletal reorganization and cell movement. Therefore, a label centered on cytoskeleton remodeling and migration best represents the cluster.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:2000584","count":2},{"id":"GO:0007162","count":2},{"id":"GO:1990314","count":2},{"id":"GO:0007266","count":2}]},{"hash":"1261050020059906430","title":"RNA Processing and Translation Regulation","description":"This cluster centers on post-transcriptional control, with strong signals for translation initiation and preinitiation complex formation, IRES-dependent translation, and spliceosome-mediated mRNA processing, plus regulatory ncRNA-mediated silencing and poly(A) tail regulation. These GO terms together point to coordinated RNA-level gene expression control, combining translation initiation with RNA processing events.","confidence":"High","size":17,"edges":7,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0048026","count":8},{"id":"GO:0075522","count":7},{"id":"GO:0006376","count":7}]},{"hash":"2040817237810601984","title":"Insect cuticle and eggshell formation","description":"These proteins show strong enrichment for insect-specific developmental processes, notably larval chitin-based cuticle development and chorion-containing eggshell formation, with multicellular organism development as a broader context. While other terms (e.g., JNK signaling, synaptic vesicle processes, neuron differentiation) appear, the most pronounced and specific functions relate to cuticle and eggshell formation during insect development, supporting this label.","confidence":"High","size":17,"edges":68,"triangles":160,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":8},{"id":"GO:0007275","count":4},{"id":"GO:0007304","count":4},{"id":"GO:0030521","count":2},{"id":"GO:0010514","count":2}]},{"hash":"629360294787963333","title":"Epithelial barrier formation and calcium transport","description":"The cluster prominently features terms related to epithelial barrier components and development (septate junction assembly, establishment of glial blood-brain barrier, regulation of tube size in tracheal systems) along with calcium transport processes (calcium ion transport, sarcoplasmic reticulum calcium transport). This points to a cohesive theme around barrier integrity and calcium-dependent signaling in development. Some terms (ascospore formation, meiosis I) seem peripheral noise rather than core cluster themes.","confidence":"Medium","size":17,"edges":81,"triangles":219,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0070588","count":2},{"id":"GO:0034765","count":2},{"id":"GO:0045671","count":2},{"id":"GO:0019991","count":2}]},{"hash":"228124485735566735","title":"Actin cytoskeleton dynamics and signaling","description":"The cluster is enriched for GO terms related to Arp2/3-mediated actin nucleation regulation (both positive and negative), regulation of GTPase activity, and phosphorylation signaling (kinase activity, tyrosine phosphorylation), along with developmental and hypoxia-related processes and mRNA transport. This pattern points to coordinated actin remodeling coupled with signaling pathways that govern cell movement and development, justifying a label focused on actin dynamics and signaling.","confidence":"High","size":17,"edges":34,"triangles":13,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034316","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0051028","count":6},{"id":"GO:0043588","count":6},{"id":"GO:2000601","count":6}]},{"hash":"2100061076709470184","title":"Mitotic progression and transcription regulation","description":"This cluster is dominated by GO terms tied to cell cycle control and mitosis, including G1/S and G2/M transitions, re-entry into mitotic cycle, and regulation of spindle pole separation, as well as DNA-templated transcription. The presence of a histone phosphorylation term related to chromosome condensation reinforces a mitotic theme, with some tissue-specific proliferation signals (mammary gland development) suggesting accompaniment by proliferative processes. Overall, the core function appears to be coordinating cell cycle progression and transcription during mitosis.","confidence":"High","size":17,"edges":19,"triangles":12,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000775","count":8},{"id":"GO:0000086","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0046626","count":8},{"id":"GO:0000320","count":8}]},{"hash":"407188480805173005","title":"Transcriptional Regulation and Ubiquitination in Cell Proliferation","description":"The Top Terms include DNA-templated transcription, regulation of ubiquitination (monoubiquitination and polyubiquitination), and the mitotic cell cycle, with additional signals related to Wnt signaling and placental development. This suggests a cohesive theme of coordinating gene expression, protein turnover, and cell division during development. Confidence: Medium","confidence":"","size":17,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0061178","count":2},{"id":"GO:0051311","count":2},{"id":"GO:0060712","count":2},{"id":"GO:1902527","count":2}]},{"hash":"113199468298868144","title":"DNA repair and retroviral latency regulation","description":"The cluster prominently features DNA metabolism terms (base-excision repair, DNA recombination, RNA-templated DNA biosynthesis) and nucleotide metabolism (AMP salvage, nucleoside monophosphate phosphorylation), pointing to genome maintenance and DNA synthesis. The presence of \u201cestablishment of integrated proviral latency\u201d and related RNA-processing regulation terms suggests a connection to retroviral DNA integration control and RNA-based regulatory mechanisms. Together, these indicate a cohesive theme around DNA repair/genome maintenance with links to retroviral latency and RNA-mediated regulation.","confidence":"Medium","size":17,"edges":115,"triangles":454,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046939","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0006284","count":5},{"id":"GO:0007568","count":5},{"id":"GO:0006310","count":5}]},{"hash":"353909511300910786","title":"Diverse Transmembrane Transporters","description":"Most of the top GO terms point to transport across membranes, including xenobiotic, vitamin, nitrate, sodium, sialic acid, and phosphate transmembrane transport, as well as neurotransmitter loading into synaptic vesicles. This pattern strongly suggests a cluster of membrane transporter proteins handling uptake and movement of ions, nutrients, and small molecules, with vesicular transport representing a related sub-function. The wide representation of transport-related terms across substrates supports a common transporter-focused theme for this cluster. ","confidence":"High","size":17,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":17},{"id":"GO:0035461","count":17},{"id":"GO:0042891","count":17},{"id":"GO:0015739","count":15},{"id":"GO:0035435","count":15}]},{"hash":"1645934895114728515","title":"Neural Development and Transcription Regulation","description":"This cluster is dominated by terms related to neural development, including forebrain development and neural tube closure, along with DNA-templated transcription, suggesting a common theme of transcriptional control guiding neural development. Other terms about cell cycle, ER stress-induced apoptosis, and defense responses are present but less central, so the label reflects the main function with some noise. ","confidence":"Medium","size":17,"edges":22,"triangles":14,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0009190","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0030900","count":3}]},{"hash":"542770126592378903","title":"Multisystem Growth Signaling","description":"The proteins show enrichment for ERK1/ERK2 cascade and PI3K/AKT signaling, plus terms related to angiogenesis, retina vasculature development, skeletal muscle and nervous system development, metabolism, and immune signaling, suggesting a broad, interconnected growth and signaling network across tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0061298","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0070371","count":5},{"id":"GO:0051897","count":4},{"id":"GO:0007519","count":4}]},{"hash":"2209604885706276018","title":"Nuclear Transcription and Chromatin Regulation","description":"The cluster mainly features GO terms tied to DNA-templated transcription, regulation of transcription elongation, and chromatin modifications (histone deacetylation and histone acetylation). This suggests a shared role in controlling gene expression at the chromatin level. Ubiquitination-related terms (protein polyubiquitination, ubiquitin-dependent ERAD) point to additional post-translational regulation, while a few immune-related terms appear less central to the core theme. Given the mix, the strongest signal is transcription/chromatin regulation with supportive ubiquitination context.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0039536","count":3}]},{"hash":"1897861126765996546","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080182","count":2},{"id":"GO:0090262","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0001711","count":2},{"id":"GO:2001173","count":2}]},{"hash":"217818440411487330","title":"Cell cycle and synaptic signaling regulation","description":"This cluster shows strong signals for DNA replication and mitotic cell cycle, with additional enrichment for synaptic transmission and plasticity\u2013related terms (glutamatergic transmission, long-term potentiation, regulation of synaptic plasticity) and regulatory processes (Wnt signaling, nuclear export). The dominant cell-cycle terms suggest a core in proliferation, while the presence of synaptic and transcriptional regulation terms indicates a broader module that links cell-cycle machinery with neuronal signaling and gene expression control.","confidence":"Medium","size":17,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":14},{"id":"GO:0000278","count":12},{"id":"GO:0090263","count":11},{"id":"GO:0034351","count":11},{"id":"GO:0046827","count":11}]},{"hash":"1985891886393928917","title":"Broad developmental differentiation and angiogenesis","description":"The top GO terms point to multiple differentiation processes across tissues (keratinocyte, B cell, trophoblast), embryonic cardiovascular development (endocardial EMT, labyrinthine layer vascular formation), and angiogenesis, with some signaling activity (I-kappaB phosphorylation) and apoptosis. This suggests a general theme of development and cell fate decisions rather than a single pathway or tissue, so a broad label capturing differentiation and vascular/organ development fits best.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0060716","count":2}]},{"hash":"1464177245672180436","title":"Unknown","description":"The GO terms are a mix of developmental, immune, neuronal, and cell-movement processes, with no clear single function unifying the cluster; assigning a specific label would be speculative.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":2},{"id":"GO:1901202","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0031104","count":2},{"id":"GO:0006956","count":2}]},{"hash":"2269958738889119094","title":"Neural development and cytoskeletal dynamics","description":"The cluster features neural development terms (spinal cord and brain development, sensory perception of sound) together with cytoskeletal/motor processes (microtubule-based movement) and signaling regulation (GTPase/Ras). This combination suggests proteins involved in neural tissue development and associated cytoskeletal and signaling regulation, rather than a single specific pathway.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0021510","count":4},{"id":"GO:0007018","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0007420","count":3}]},{"hash":"1541675648683448798","title":"Membrane Transporters and Immune Stress Signaling","description":"The top GO terms point to membrane transport activities (vitamin, sodium, and potassium transmembrane transport) alongside immune-related responses (cellular response to lipopolysaccharide and defense against Gram-positive bacteria) and transcriptional regulation. This suggests a cluster of proteins that participate in membrane transport with concurrent involvement in stress- or immune-related signaling and transcriptional control under such conditions, even though the interaction structure shows no edges. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0001403","count":3}]},{"hash":"1686273311491229967","title":"Biogenic amine biosynthesis and stress-related metabolism","description":"Top GO terms cluster around monoamine biosynthesis (dopamine, serotonin, epinephrine) from tyrosine/tryptophan, with related associations to eating behavior and stress responses; this suggests a cohesive theme of neurotransmitter production and its behavioral regulation. Some terms appear noisy or incidental (e.g., development or pigmentation), but the prominent signal is monoamine biosynthesis. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060749","count":2},{"id":"GO:0006585","count":2},{"id":"GO:0042755","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006587","count":2}]},{"hash":"478515861645629146","title":"Mitochondrial transporters for metabolites and ions","description":"The top GO terms are dominated by various transport activities into or across the mitochondrial membrane (ADP transport, pyrimidine nucleotide import, CoA transport, iron and manganese ion transport, thiosulfate transport), pointing to a cluster of mitochondrial metabolite/ion transport proteins. Some terms (e.g., obsolete or broad processes) are likely noise, but the core theme strongly supports mitochondrial transporter function.","confidence":"High","size":17,"edges":12,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":7},{"id":"GO:0097274","count":6},{"id":"GO:0000002","count":6},{"id":"GO:0048250","count":5},{"id":"GO:0015709","count":5}]},{"hash":"30685327584543173","title":"Transcription Regulation and Vascular Remodeling","description":"The top GO terms indicate strong involvement in RNA polymerase II transcription regulation (both negative and positive), complemented by processes related to endothelial barrier establishment, tissue remodeling, fibrinolysis, and coagulation (Factor XII activation), with accompanying neutrophil-mediated immune activity. This pattern points to a cluster of proteins that link transcriptional control with vascular remodeling and inflammation/coagulation processes, rather than a single narrow function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0045944","count":8},{"id":"GO:0030901","count":8},{"id":"GO:1903142","count":7},{"id":"GO:0070947","count":7}]},{"hash":"741336382131751979","title":"ER-Golgi Secretory Vesicle Transport","description":"This cluster centers on vesicle trafficking within the secretory pathway, especially ER-to-Golgi and Golgi-to-ER transport, plus related anterograde synaptic vesicle transport and regulation of GTPase activity, pointing to a cohesive theme of intracellular trafficking and secretion. Some terms like pigmentation and Purkinje cell maturation may reflect context-specific roles of transport in pigment cells and neurons, but the dominant signal is vesicle transport in the secretory pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009615","count":2},{"id":"GO:0032024","count":2},{"id":"GO:0043087","count":2},{"id":"GO:0048490","count":1},{"id":"GO:0043473","count":1}]},{"hash":"2180774317885159279","title":"Unknown","description":"The top terms span very different biological contexts (ion transport, neuronal/startle responses, animal innate immune signaling, and plant development), and the cluster has no edges linking them. There isn\u2019t a single coherent function tying these proteins together, so a meaningful, specific label isn\u2019t supported.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0001964","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0071372","count":2},{"id":"GO:0007252","count":2}]},{"hash":"501208795543221010","title":"Coagulation and Immune Activation with ECM Remodeling","description":"This cluster centers on genes/proteins involved in blood coagulation, fibrinolysis, and complement activation, alongside innate immune responses to lipopolysaccharide and monocyte recruitment. The presence of collagen catabolic processes and endochondral ossification suggests extracellular matrix remodeling and connective tissue turnover, while signals for blood pressure regulation and renal sodium excretion point to vascular/renal coordination. Together these terms indicate a cohesive theme of coagulation and immune signaling coupled with tissue remodeling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0032496","count":4},{"id":"GO:0001958","count":4},{"id":"GO:0045777","count":3},{"id":"GO:0090026","count":3}]},{"hash":"1198765950119937651","title":"Mitotic progression and chromatin regulation","description":"The proteins are enriched for cell-cycle and mitotic processes (G1/S and G2/M transitions, spindle pole separation, mitotic re-entry) along with chromatin-related events (histone H3S10 phosphorylation, DNA repair) and transcriptional activity, pointing to a cluster that coordinates cell division with chromatin dynamics and proliferation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0033598","count":4},{"id":"GO:0000082","count":4},{"id":"GO:0010696","count":4},{"id":"GO:0000086","count":4}]},{"hash":"204181614292677335","title":"mRNA Splicing and Translation Regulation","description":"This cluster is enriched for mRNA processing and splicing terms (spliceosome-mediated splicing, splice-site recognition, and polyadenylation regulation) along with regulation of mRNA stability, ncRNA-mediated gene silencing, and translation initiation/reinitiation (including IRES-dependent translation). The convergence on spliceosome activity and post-transcriptional control suggests proteins coordinating mRNA maturation with subsequent translation, rather than a single metabolic process.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":13},{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:0006378","count":11},{"id":"GO:0045292","count":11}]},{"hash":"1316846443396979359","title":"Cell cycle and DNA replication with innate immunity","description":"The cluster is driven by core cell cycle and DNA replication processes (DNA replication, centrosome cycle, positive/negative regulation of cell proliferation, nuclear export), with notable innate immune terms (innate immune response, defense against Gram-positive bacteria) suggesting an association between cell cycle machinery and immune signaling, plus a few developmental processes that indicate broader regulatory roles.","confidence":"Medium","size":16,"edges":13,"triangles":3,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0045087","count":8},{"id":"GO:0008285","count":8},{"id":"GO:0050830","count":8},{"id":"GO:0010571","count":7}]},{"hash":"958722524531058481","title":"Immune Response Activation and Signaling","description":"The cluster is enriched for innate and adaptive immune response terms, including positive regulation of IL-2 production and glucocorticoid signaling, pointing to a central theme of immune activation and signaling. While there are also metabolic and structural terms (pantothenate biosynthesis, NADPH regeneration, cuticle and muscle development), these appear peripheral to the main immune-related pattern, suggesting the core function relates to immune processes.","confidence":"Medium","size":16,"edges":11,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0002250","count":2},{"id":"GO:2000324","count":2},{"id":"GO:0015940","count":2},{"id":"GO:0006740","count":2}]},{"hash":"326025438677056583","title":"ER stress and apoptosis regulation","description":"Proteins in this cluster are enriched for ER-related processes (protein folding in the ER, ERAD) and post-translational targeting, with supporting terms in redox homeostasis and mitochondrial-related functions, plus apoptosis signaling. This pattern points to a cohesive role in ER stress response and the crosstalk between ER quality control and mitochondrial/apoptotic pathways, with some transcriptional regulation context as a broader regulatory layer.","confidence":"Medium","size":16,"edges":12,"triangles":0,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0034975","count":2},{"id":"GO:0045454","count":2}]},{"hash":"1132570045128840868","title":"Golgi trafficking and NF-\u03baB signaling","description":"This cluster is driven by terms about Golgi organization and Golgi-to-lysosome transport, pointing to vesicular trafficking as a core function. It also includes links to ERAD and protein quality control, and references to NF-\u03baB and TNF signaling, suggesting a connected role in inflammatory signaling and immune-related processes that interface with trafficking. While there are hints of development (digit morphogenesis) and Rho signaling, the strongest common thread appears to be Golgi-based trafficking with accompanying signaling roles.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903358","count":2},{"id":"GO:0090160","count":2},{"id":"GO:0031954","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0030433","count":2}]},{"hash":"1784502897624520170","title":"Developmental signaling and axon guidance","description":"This cluster is enriched for signaling pathways and developmental processes, especially neural patterning and axon guidance (ROBO signaling, Hedgehog via Smoothened, ERK/MAPK regulation), plus broader organ development terms like kidney, bone ossification, and spermatid development, suggesting a cohesive role in developmental signaling and morphogenesis.","confidence":"High","size":16,"edges":53,"triangles":39,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0007411","count":7},{"id":"GO:0002551","count":7},{"id":"GO:0007399","count":7}]},{"hash":"1674538897409372746","title":"Unknown","description":"The top GO terms span plant photosynthesis, neural development, insulin response, UV-A response, ER stress-related translation initiation, and cardiovascular regulation, with several obsolete terms. This broad, heterogeneous set provides no cohesive biological function linking the proteins, so an Unknown label with no confidence is appropriate.","confidence":"","size":16,"edges":21,"triangles":23,"max_degree":8,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0032869","count":4},{"id":"GO:0019878","count":4},{"id":"GO:0036494","count":3},{"id":"GO:0003085","count":3},{"id":"GO:0015979","count":3}]},{"hash":"471429052191501143","title":"Bone remodeling and ECM degradation","description":"The cluster is dominated by terms tied to bone formation and resorption (intramembranous ossification, bone resorption, collagen catabolic process) and basement membrane remodeling, with supporting signals from Wnt pathway involvement and thyroid hormone response, all pointing to coordinated extracellular matrix remodeling in skeletal contexts. Some terms like decidualization or neuropeptide catabolism appear peripheral but do not overshadow the central bone/ECM remodeling theme.","confidence":"High","size":16,"edges":59,"triangles":110,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0097067","count":8},{"id":"GO:0001957","count":8},{"id":"GO:0035593","count":7},{"id":"GO:0046697","count":7},{"id":"GO:0010813","count":7}]},{"hash":"2196688665451057421","title":"Developmental Signaling and Axon Guidance","description":"The cluster is enriched for GO terms spanning development and signaling across tissues, including nervous system development, axon guidance, Slit-Robo signaling, Shh/Smoothened signaling, and bone ossification, with additional immune signaling like T cell receptor signaling and mast cell chemotaxis. This points to a cohesive theme of developmental signaling networks rather than a single pathway, making this label appropriate and specific.","confidence":"Medium","size":16,"edges":84,"triangles":227,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0035385","count":14},{"id":"GO:0001822","count":14},{"id":"GO:0007224","count":14}]},{"hash":"1258782888540390525","title":"Embryonic Mesoderm and Placental Development","description":"The top GO terms cluster around embryonic development, notably mesoderm formation, epithelial-to-mesenchymal transition in heart structures (endocardial cushion formation), and placenta development, with supporting transcriptional regulatory process terms. Despite some obsolete terms and transcription-related noise, the dominant theme is embryogenesis and tissue lineage specification, justifying this label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":3},{"id":"GO:0010957","count":3},{"id":"GO:0051220","count":3},{"id":"GO:1903026","count":3},{"id":"GO:0003198","count":3}]},{"hash":"1827872018794274632","title":"Dopaminergic Synapse Regulation and Proteostasis","description":"This cluster is driven by GO terms pointing to neuronal signaling at dopaminergic synapses (GO:0032226) and regulation of proteolysis/peptidase activity, as well as membrane raft localization, suggesting coordinated signaling and protein turnover at synaptic sites; some mitochondrial and ERAD-related terms may reflect general cellular quality control but are less central. Overall the theme is synaptic regulation with proteostasis and membrane organization.","confidence":"Medium","size":16,"edges":34,"triangles":30,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0032226","count":4},{"id":"GO:0000001","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0060355","count":3},{"id":"GO:1901585","count":3}]},{"hash":"1504313834082175828","title":"Nucleocytoplasmic export of ribosomal subunits and mRNA","description":"The top GO terms are dominated by export of ribosomal large and small subunits from the nucleus and mRNA export, indicating a cluster centered on nucleocytoplasmic transport of ribosome components and transcripts. We also see weaker signals for xenobiotic/nutrient responses and transcription regulation, which do not override the primary transport theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000056","count":2},{"id":"GO:0000060","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0006406","count":2}]},{"hash":"1390172744901555828","title":"Neural development signaling and axon guidance","description":"The cluster is dominated by GO terms tied to neural development and neuronal connectivity, including neurogenesis, nervous system development, axon guidance, neuron projection development, and myelination. The presence of Roundabout (Slit-Robo) and Smoothened (Hedgehog) signaling pathways reinforces a pattern of neural development and guidance signaling, with a smaller subset related to general intracellular trafficking and non-neural development that may reflect broader roles or co-annotation. Overall, the strongest signal points to neural development and axon guidance as the shared theme.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0022008","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0035385","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0006888","count":5}]},{"hash":"1588134149417620123","title":"Insect appendage development and morphogenesis","description":"This cluster centers on developmental morphogenesis of insect appendages and tissues, highlighted by proboscis development, imaginal disc\u2013derived leg joint morphogenesis, and embryonic limb morphogenesis, with Wnt signaling supporting these processes. While there are a few broader or cross-species terms, the dominant theme is appendage/organ development in insects.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048728","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0031214","count":2},{"id":"GO:0035115","count":1},{"id":"GO:0010944","count":1}]},{"hash":"2068442927814741764","title":"Eggshell formation and development","description":"Dominant terms are multicellular organism development and chorion-containing eggshell formation, pointing to a module specialized in eggshell production during development. Other GO terms (lipid biosynthesis, methylation, ribosomal export, etc.) appear but with weaker support, likely reflecting housekeeping processes. Therefore the label captures the core theme of eggshell formation within a developmental context.","confidence":"Medium","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0007304","count":3},{"id":"GO:0006656","count":1},{"id":"GO:0036265","count":1},{"id":"GO:0006744","count":1}]},{"hash":"1620786037957002732","title":"Developmental signaling and cytoskeletal regulation","description":"The top GO terms point to skin and multicellular development, cell division, GTPase activity regulation (notably Rho signaling), protein oligomerization, calcium release, and broader developmental processes, suggesting a cluster tied to developmental signaling coordinated with cytoskeletal dynamics and cellular differentiation.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0043588","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0007275","count":3}]},{"hash":"2100587441283420056","title":"Neural tube and forebrain development","description":"The top GO terms are dominated by neural development signals (neural tube closure, forebrain development) along with broader multicellular development and growth terms. While other terms (mitotic cell cycle, skeletal system development, SREBP signaling) appear, the strongest and most specific enrichment points to early neural development processes, especially brain formation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0032933","count":4}]},{"hash":"1396898405877097738","title":"Membrane Transporters","description":"The GO terms are dominated by various transmembrane transport processes across the plasma membrane, including sodium, potassium, trehalose, urate, vitamins, xenobiotics, and organic anions, with an additional link to cellular responses under glucose starvation. This pattern suggests a cluster of proteins functioning as membrane transporters with diverse substrates.","confidence":"High","size":16,"edges":22,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":13},{"id":"GO:0071805","count":13},{"id":"GO:0015771","count":11},{"id":"GO:0006855","count":11},{"id":"GO:0015747","count":11}]},{"hash":"495419230006906830","title":"Mitochondrial Metabolite and Ion Transporters","description":"This cluster centers on membrane transport activities, especially transport into and across the mitochondrial membranes. Key terms include ADP transport, iron and manganese ion import into mitochondria, heme and coenzyme A transmembrane transport, thiosulfate transport, and pyrimidine nucleotide import, all pointing to mitochondrial metabolite and ion flux. The presence of a oxidative stress response term also aligns with mitochondrial physiology. Overall, the proteins are best described as mitochondrial transporters handling diverse metabolites and ions.","confidence":"High","size":16,"edges":15,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015886","count":8},{"id":"GO:0097274","count":8},{"id":"GO:0048250","count":7},{"id":"GO:0015709","count":7},{"id":"GO:0015866","count":7}]},{"hash":"213033848506847251","title":"Ubiquitin-Dependent Protein Degradation","description":"Most terms point to ubiquitin-mediated processes: ubiquitin-dependent protein catabolic process, ERAD, polyubiquitination, and K48-linked ubiquitination, along with Wnt receptor turnover. While a few terms touch chromatin regulation (V(D)J recombination, histone modification) the dominant signal is proteostasis via the ubiquitin\u2013proteasome system and related degradation pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0030433","count":6},{"id":"GO:0000209","count":5},{"id":"GO:0046621","count":4},{"id":"GO:0033151","count":4}]},{"hash":"1513176073910615889","title":"RNA transcription and ribosome biogenesis","description":"This cluster is dominated by GO terms related to transcription by RNA polymerases I, II, and III (DNA-templated transcription, RNA-templated transcription, transcription by RNA Pol II, termination, elongation) and a ribosome biogenesis term, suggesting a core theme around gene expression machinery and ribosome production. A few terms are peripheral or obsolete, but the primary signal is transcription-related processes with a link to ribosome biogenesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006369","count":1},{"id":"GO:0070893","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0006366","count":1}]},{"hash":"124059258871448442","title":"Developmental Morphogenesis","description":"This cluster centers on development and morphogenesis, with terms like multicellular organism growth, skeletal system morphogenesis, and spinal cord development, complemented by microtubule-based movement that supports cell and tissue formation. A few terms (defense response to Gram-positive bacteria, rRNA processing) may reflect annotation noise rather than core function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0014068","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0060770","count":3},{"id":"GO:0035264","count":3}]},{"hash":"596055327583975920","title":"Cell Division and Growth Signaling","description":"The top GO terms point to mitosis and cell cycle (mitotic cell cycle, cell division) while also highlighting growth and gene-expression coordination (mRNA transport, TORC1 signaling, positive regulation of GTPase activity, serine dephosphorylation). Together, they reflect a cluster of proteins that link cell-cycle progression with nutrient/growth signaling and regulatory signaling. The presence of neural/glial apoptotic terms may indicate stress-related regulation rather than core function. Confidence: High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051028","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0097274","count":4}]},{"hash":"159397954934785487","title":"Developmental transcriptional regulation and chromatin modification","description":"This cluster's terms cluster around controlling gene expression and chromatin state in development and cell cycle contexts. Prominent GO terms include positive regulation of transcription by RNA polymerase II and DNA-templated transcription, as well as histone modification marks such as H3K36 and H3K4 methylation. Additional terms emphasize cell cycle control (G1/S transition) and developmental processes (forebrain development, placental morphogenesis, vasculogenesis). Taken together, the proteins likely function as components of transcriptional regulation with chromatin-modifying activity during development and cell cycle progression.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0035441","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0060669","count":2},{"id":"GO:0097198","count":2}]},{"hash":"1529010488936134172","title":"Unknown","description":"The terms are heterogeneous, spanning DNA integration, antibiotic response, amino acid metabolism, phosphorylation, signaling, and various developmental processes, with no clear unifying function to define a cohesive label.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0019284","count":1},{"id":"GO:0019509","count":1},{"id":"GO:0009088","count":1}]},{"hash":"358066476341947960","title":"ER-Golgi Vesicle Trafficking and Secretion","description":"The cluster is dominated by GO terms for vesicle transport within the secretory pathway\u2014ER to Golgi, Golgi to plasma membrane, and retrograde Golgi-ER transport\u2014as well as positive regulation of intracellular protein transport. This points to a cohesive theme of protein trafficking and surface delivery, with insulin signaling and other terms likely modulating these processes; a few outliers (DNA integration, a developmental term) likely reflect incidental associations. Overall, the data best support a label centered on secretory pathway trafficking.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0090316","count":2},{"id":"GO:0043001","count":2}]},{"hash":"1344792046021612849","title":"Amino acid and small-molecule membrane transport","description":"Most top GO terms describe transport across the plasma membrane for amino acids (arginine, lysine, D-alanine, D-serine, GABA) and related solutes (polyamines, carnitine). A few terms relate to detoxification or obsolete signaling, but the predominant pattern is transmembrane transport of small molecules, suggesting a cluster of transporter proteins rather than enzymes. ","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0015812","count":2},{"id":"GO:1902269","count":2},{"id":"GO:0097638","count":2}]},{"hash":"831278567453259367","title":"Unknown","description":"The top GO terms span diverse biological areas\u2014plant-specific metabolite catabolism (glucosinolate, cellulose, lactose), multiple signaling pathways (insulin receptor, cytokinin), RNA processing, histone ubiquitination, and general protein turnover\u2014without a single cohesive function tying all 16 proteins together. The lack of edges or shared functional coupling further supports that there isn\u2019t a clear, unified cluster theme to name.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019762","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0070535","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0009736","count":3}]},{"hash":"29046574990753188","title":"Unknown","description":"The top terms show a mix of diverse processes\u2014several metabolic pathways (cholesterol, methane, methanol, glycine betaine biosynthesis) alongside development (in utero embryonic development, gastrulation, neuron maturation) and an immune response (response to lipopolysaccharide). This combination across metabolism and development without a clear, single overarching function suggests there is no coherent theme tying the cluster together. Additionally, some terms are obsolete, reducing interpretability. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0008203","count":6},{"id":"GO:0046188","count":6},{"id":"GO:0015945","count":6},{"id":"GO:0019285","count":6}]},{"hash":"664722249211075542","title":"Transcriptional and Signaling Regulators","description":"The terms show frequent regulation of DNA-templated transcription, promoter activity, and multiple signaling pathways (Wnt and TGF-\u03b2), plus protein ubiquitination. This suggests these proteins primarily function as regulators of gene expression and cell signaling rather than core structural components.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0030512","count":2},{"id":"GO:0090074","count":1}]},{"hash":"1612478316523042627","title":"Actin cytoskeleton remodeling and cell motility","description":"This cluster is dominated by GO terms related to actin filament organization and cytoskeleton remodeling (actin organization, actin cytoskeleton reorganization, vesicle transport along actin), along with themes of membrane remodeling and cell adhesion/motility (plasma membrane tubulation, cell motility in certain contexts, cadherin-mediated adhesion). While there are a couple of immune-related terms, the strongest and most frequent signals point to actin dynamics driving cell movement and vesicular trafficking. High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007015","count":2},{"id":"GO:0021816","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0097320","count":2},{"id":"GO:0045087","count":2}]},{"hash":"837736464790833443","title":"Pain and temperature sensing with cardiac conduction","description":"The terms show a clear focus on nociception and thermoception (startle response, response to pain, detection of temperature stimulus) alongside cardiac signaling (Purkinje-to-ventricular signaling, regulation of heart rate by cardiac conduction). This suggests a cluster of proteins involved in sensory processing under autonomic cardiac control, with a minor immune-related term. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":2},{"id":"GO:0048265","count":2},{"id":"GO:0002724","count":1},{"id":"GO:0051928","count":1},{"id":"GO:0008627","count":1}]},{"hash":"1225895623524077124","title":"Ribosome Biogenesis and Translation Initiation","description":"This cluster centers on ribosome production and the control of protein synthesis. Key terms include maturation of LSU rRNA, assembly of the large-subunit preribosome, and multiple stages of translation initiation and reinitiation (formation of preinitiation complexes, regulation of translational initiation, and IRES-dependent initiation). While it also touches on broader RNA processing and transcriptional regulation, the strongest, coherent signal is ribosome biogenesis paired with post-transcriptional translation control.","confidence":"High","size":15,"edges":17,"triangles":6,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006283","count":3},{"id":"GO:0000463","count":3},{"id":"GO:1902626","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3}]},{"hash":"694873276404671637","title":"RNA Processing and Genome Maintenance","description":"The cluster is dominated by RNA metabolism terms: nonsense-mediated decay, spliceosome-mediated mRNA splicing, and maturation of LSU-rRNA, indicating RNA processing and quality control. There are supporting signals for genome integrity (UV protection and DNA repair-related processes) and ancillary hints of cytoskeletal signaling (Arp2/3 regulation, GTPase activity) with a developmental context (embryonic organ development). Taken together, it points to a broad RNA-processing and genome-maintenance cluster with developmental signaling aspects, rather than a single cohesive module.","confidence":"Medium","size":15,"edges":29,"triangles":21,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048568","count":5},{"id":"GO:0000184","count":4},{"id":"GO:0034316","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000463","count":3}]},{"hash":"33429866010476515","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":92,"triangles":316,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":10},{"id":"GO:0030433","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0070843","count":2}]},{"hash":"1075141908947670746","title":"Developmental Transcription Regulators","description":"This cluster shows consistent signals for embryonic development in multiple structures (endocardial cushion, outflow tract, rhombomeres, brain, palate) coupled with transcription regulation (DNA-templated transcription and RNA Pol II modulation). The common thread appears to be proteins involved in controlling transcription during development, rather than a single tissue-specific role.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0003148","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0000122","count":4}]},{"hash":"1487037184300503366","title":"Zinc Ion Transport and Homeostasis","description":"The dominant GO terms are about zinc import across membranes, intracellular zinc ion homeostasis, detoxification, and response to zinc ion starvation, indicating a coordinated zinc regulation module\u2014likely zinc transporters and homeostasis regulators. A few outliers (larval cuticle development, obsolete polyadenylation) are less connected to this core theme.","confidence":"High","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0006882","count":1},{"id":"GO:0044749","count":1},{"id":"GO:0070574","count":1}]},{"hash":"1924215408351299748","title":"Biosynthesis and metabolic regulation","description":"The top GO terms point to multiple biosynthetic pathways (cobalamin, protoporphyrinogen IX, biotin, antibiotic biosynthesis) and metabolic states (aerobic respiration, insulin-responsive regulation) along with transcriptional control (DNA-templated transcription) and stress responses. Although a developmental term appears, the dominant signal is metabolic biosynthesis and regulatory processes, suggesting a cluster of proteins involved in biosynthesis pathways and their transcriptional/metabolic regulation.","confidence":"Medium","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0009236","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0009102","count":2}]},{"hash":"130961384269459635","title":"TCA Cycle and Amino Acid Biosynthesis","description":"The cluster centers on central carbon metabolism: 2-oxoglutarate metabolism, TCA and glyoxylate cycles, NADP+ biosynthesis, and amino acid biosynthesis (leucine, lysine). A few outlier GO terms (female gonad development, steroid hormone response) may reflect annotation noise rather than a true functional theme. Overall, the dominant signal is metabolic, justifying the label.","confidence":"Medium","size":15,"edges":42,"triangles":45,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006103","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0006097","count":2},{"id":"GO:0006741","count":2}]},{"hash":"623104562631255234","title":"Embryonic organogenesis and placental development","description":"This cluster's top GO terms span diverse embryonic development processes, including pancreas development, endocardial cushion/heart morphogenesis, cartilage morphogenesis, placental/trophoblast differentiation, endocrine system development, and left-right pattern formation, indicating a cohesive theme of embryonic organogenesis and tissue differentiation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060707","count":2}]},{"hash":"606400161759989107","title":"Thermogenesis and Ion Homeostasis","description":"This cluster centers on metabolic heat production and maintenance of ionic balance, highlighted by terms for temperature response and diet-induced thermogenesis, together with multiple ion transport and homeostasis terms (sodium/potassium), plus energy production (electron transport chain) and related signaling that influence blood pressure and immune signaling. While there is some immune signaling overlap, the strongest recurring theme is thermogenic metabolism coupled with ion homeostasis. ","confidence":"Medium","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0098719","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0097623","count":6}]},{"hash":"2039870267923037635","title":"Unknown","description":"This cluster contains a mixed set of functions spanning basic gene expression (ribosome biogenesis, cytoplasmic translation, transcription, splicing regulation) and broad developmental processes (neurogenesis, axon regeneration, vagina development) alongside host-pathogen related terms (virion attachment to host cell, autophagy activation by symbiont) and apoptosis. The diverse, seemingly unrelated themes do not point to a single coherent functional category, so a specific, representative label is not evident.","confidence":"","size":15,"edges":14,"triangles":8,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0019062","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0039520","count":2},{"id":"GO:0006351","count":2}]},{"hash":"544061630522239850","title":"Ribosome Biogenesis and Translation","description":"The top GO terms center on ribosome biology and protein synthesis\u2014translation, ribosome disassembly, rRNA maturation, ribosomal subunit export, and processes ensuring translational fidelity, plus translation termination. This cohesive set points to a cluster focused on ribosome assembly/biogenesis and function, with some related transcription and cell-cycle links.","confidence":"High","size":15,"edges":49,"triangles":73,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0007049","count":3},{"id":"GO:0032790","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0000462","count":2}]},{"hash":"1117212357185589891","title":"EGFR-driven growth and translational regulation","description":"The top terms point strongly to translation and its regulation (translation, translational fidelity, translational elongation) alongside EGFR signaling and developmental processes (oogenesis, glial cell proliferation) and apoptosis, suggesting a functional theme of protein synthesis control within growth/development signaling contexts. Ancillary terms like DNA integration and RNAi-related chromatin regulation may reflect broader genome regulation during development or stress. Overall, the cluster seems to center on growth signaling coupled with translational control, hence this label.","confidence":"Medium","size":15,"edges":19,"triangles":14,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0007173","count":2},{"id":"GO:0048477","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1593174411596675513","title":"Golgi-mediated protein trafficking","description":"Top GO terms indicate transport to/from the Golgi (Golgi to endosome, Golgi to plasma membrane) and protein localization to the Golgi, suggesting a cohesive function in Golgi-dependent trafficking. Some other terms (transcription regulation, antibiotic response) are less directly connected and may reflect broader annotations or multifunctionality, but the dominant signal is Golgi trafficking activity.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0006895","count":1},{"id":"GO:0000042","count":1},{"id":"GO:0043001","count":1}]},{"hash":"1913965343266782681","title":"Unknown","description":"The GO terms in this cluster are highly heterogeneous, spanning transcription regulation, behavior, photosynthesis, amyloid formation, and several sugar/ polysaccharide biosynthesis processes. There is no clear, shared function that ties all proteins together, so a cohesive label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0015979","count":2},{"id":"GO:1990000","count":2},{"id":"GO:0009298","count":1}]},{"hash":"1175113458514285050","title":"Adrenergic GPCR Signaling in Heart and Behavior","description":"This cluster is dominated by GO terms centered on G protein-coupled receptor signaling tied to adrenergic receptors (epinephrine/norepinephrine) and downstream cAMP/cGMP pathways, affecting heart rate, smooth muscle regulation, and hormone secretion, with additional signals related to grooming and feeding behavior. The convergence on adenylate cyclase-activating/inhibiting adrenergic pathways and adenosine receptor signaling supports a cohesive adrenergic signaling module impacting cardiovascular and neural functions.","confidence":"High","size":15,"edges":9,"triangles":1,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060259","count":13},{"id":"GO:0001996","count":13},{"id":"GO:0007199","count":13},{"id":"GO:0045986","count":13},{"id":"GO:0007625","count":13}]},{"hash":"412062176932669426","title":"Mitochondrial Transport and Fission","description":"The GO terms are dominated by mitochondrial-related processes: mitochondrial membrane fission, import/transport of various metabolites and ions (ADP, pyrimidine nucleotides, CoA, iron, manganese), and associated transport activities (thiosulfate). While a couple terms are less clearly connected (urea homeostasis, female pregnancy), the overall pattern points to mitochondrial transport and membrane dynamics as the cluster\u2019s shared function.","confidence":"Medium","size":15,"edges":16,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090149","count":8},{"id":"GO:0000002","count":8},{"id":"GO:0048250","count":6},{"id":"GO:0015709","count":6},{"id":"GO:0015866","count":6}]},{"hash":"773246381067341300","title":"Cellular stress response and apoptosis","description":"The cluster centers on responses to xenobiotic stimuli, redox balance, and apoptotic processes, with additional signals for immune/stress response and transcription regulation; together these terms point to a theme of cellular stress management leading to apoptosis, even though some terms are less coherent or outdated.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0055114","count":4}]},{"hash":"388156951357187567","title":"Neural development and cytoskeletal dynamics","description":"The cluster is enriched for neural development terms (brain, forebrain, spinal cord, neuron projection development) and cytoskeletal remodeling processes (actin depolymerization, microtubule-based movement), suggesting involvement in neurite outgrowth and neural morphogenesis. A lens differentiation term is present but does not override the dominant neural-development/cytoskeletal theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":3},{"id":"GO:0035264","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0030042","count":2}]},{"hash":"107977205253772603","title":"Sleep-Circadian Neural Signaling","description":"This cluster centers on neuronal signaling and circadian sleep regulation, highlighted by terms for sleep, rhythmic processes, and regulation of cholinergic synaptic transmission and neuronal excitability (voltage-gated K+ channels). While some insect-specific developmental processes are present (cuticle biosynthesis, tracheal regulation), the dominant theme ties neural signaling to sleep/circadian control, supporting a label focused on sleep and circadian neural regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:1903818","count":2},{"id":"GO:0045187","count":2},{"id":"GO:0048511","count":2},{"id":"GO:0032222","count":2}]},{"hash":"1170070514139214027","title":"Neuronal development and synaptic vesicle exocytosis","description":"The cluster is dominated by GO terms for brain and nervous system development, regulation of synaptic vesicle exocytosis, calcium-dependent exocytosis, and dendritic spine formation, with associated Golgi-to-plasma membrane transport, pointing to neuronal development and synaptic transmission.","confidence":"High","size":15,"edges":12,"triangles":0,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:2000300","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0045956","count":5},{"id":"GO:0060999","count":5}]},{"hash":"1523324974451516020","title":"Chromatin remodeling and transcriptional regulation in plant development","description":"This cluster centers on chromatin dynamics and transcription control, with GO terms for DNA transposition, nucleosome mobilization, histone exchange, heterochromatin formation, and transcription initiation. It also includes RNA-based regulatory processes and developmental patterning terms (segment specification, vegetative-to-reproductive transition) and even a link to signaling via Wnt/planar cell polarity. Together, they suggest proteins that couple chromatin state to transcriptional programs governing plant development.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0006367","count":1},{"id":"GO:0042766","count":1},{"id":"GO:0043486","count":1}]},{"hash":"1561356712301864953","title":"Growth, Signaling, and Cytoskeletal Dynamics","description":"This cluster centers on growth-related processes (multicellular organism growth, mitotic cell cycle) plus broad signaling and cytoskeletal remodeling (Arp2/3-mediated actin nucleation, GTPase regulation, tyrosine phosphorylation, TGF-beta response). It also includes mRNA transport and chromatin organization, hinting at coordinated regulation of gene expression and structural dynamics during growth and stress responses (hypoxia, immune defense). The common theme is a general growth/signaling program intertwined with cytoskeletal and transcriptional regulation, rather than a single specific pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":9},{"id":"GO:0051028","count":8},{"id":"GO:2000601","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0043547","count":8}]},{"hash":"905856781301082066","title":"GPCR-cAMP Signaling in Vascular and Immune Regulation","description":"The dominant GO terms point to GPCR signaling that activates adenylate cyclase and increases cAMP, which is central to vascular tone and blood pressure regulation, plus enrichment for monocyte chemotaxis and GTPase regulation, suggesting broader signaling and immune-related roles. While an energy/metabolism term (electron transport chain) and retina development appear among terms, the core theme remains GPCR-cAMP\u2013driven signaling influencing cardiovascular and immune processes; retina-related term may reflect shared signaling components or pleiotropy. Overall, a GPCR-cAMP\u2013centric vascular/immune regulation cluster best fits the data.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0010579","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0007190","count":11},{"id":"GO:0008283","count":10}]},{"hash":"769505170556847527","title":"Innate Immune Signaling (TLR/NF-kB)","description":"The top terms center on innate immune pathways, including TLR1 signaling, I-kappaB phosphorylation, and interferon production, indicating a shared function in immune signal transduction and kinase regulation. Some terms related to plant development appear as possible annotation noise, but they do not override the dominant immune-related theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0007252","count":2},{"id":"GO:0071726","count":2},{"id":"GO:0034130","count":2}]},{"hash":"1019580575182737987","title":"GPCR-ERK signaling with angiogenesis","description":"The cluster is dominated by GO terms related to GPCR signaling and ERK cascade activation, along with angiogenesis and vascular regulation (angiogenesis, positive regulation of blood pressure). A neural/adhesion angle appears via synapse assembly and cell adhesion terms, suggesting a signaling network theme linking vascular and neural development or function. Some metabolic terms are present but appear peripheral to the main theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0010579","count":2},{"id":"GO:0022900","count":2},{"id":"GO:0007190","count":2}]},{"hash":"1818236692229526634","title":"Diverse Metabolic Biosynthesis and Catabolism","description":"This cluster shows a mix of biosynthetic and catabolic GO terms across lipids (lipoprotein, triglyceride), nucleotides (NAD+ biosynthesis, uracil catabolic), central carbon metabolism (oxaloacetate), and secondary metabolism (antibiotic biosynthetic, 3-phenylpropionate catabolic), plus redox and metal stress (oxidation-reduction, response to cadmium ion). There isn\u2019t a single cohesive pathway dominating, so it appears to reflect broad metabolic capacity rather than a specific function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042158","count":2},{"id":"GO:0009435","count":2},{"id":"GO:0006596","count":2},{"id":"GO:0006107","count":2}]},{"hash":"986164033724464414","title":"Synaptic organization and spine morphogenesis","description":"The proteins in this cluster prominently feature GO terms tied to synaptic localization, receptor clustering, and dendritic spine morphogenesis, complemented by Rho-mediated signaling that governs actin remodeling in spines. Together, these terms suggest a cohesive theme around neuronal synapse assembly and spine development. Some terms like blood coagulation, angiogenesis, and lipopolysaccharide response are less directly related and may reflect broad annotations, but the strongest signals point to synaptic organization and signaling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0043113","count":3}]},{"hash":"115825451502613797","title":"Neural morphogenesis and synaptic signaling","description":"The terms point to neural development and nerve morphology (optic nerve morphogenesis, branching morphogenesis of a nerve, axial mesoderm formation) and to synaptic function, particularly glutamatergic transmission and plasticity (positive regulation of synaptic transmission, long-term synaptic plasticity, GKAP clustering). These together suggest a cluster of proteins involved in forming and modulating neural circuits, including sensory neurons.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048671","count":5},{"id":"GO:0051497","count":5},{"id":"GO:0048320","count":4},{"id":"GO:0071372","count":4},{"id":"GO:0048170","count":4}]},{"hash":"1427559378965529660","title":"Fatty acid metabolism","description":"These GO terms cluster around fatty-acyl-CoA biosynthesis and fatty acid catabolism (long-, medium-, and short-chain). The presence of palmitic acid biosynthesis and related catabolic processes dominates, with a few ancillary terms (like enterobactin biosynthesis and transcription regulation) likely reflecting secondary associations. Overall, the dominant theme is lipid metabolism, so Fatty acid metabolism is an appropriate label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035338","count":1},{"id":"GO:0045717","count":1},{"id":"GO:1900535","count":1},{"id":"GO:0009239","count":1},{"id":"GO:0036114","count":1}]},{"hash":"53306361389598145","title":"Immune Cell Cytoskeletal Remodeling and Migration","description":"The top GO terms reveal an immune context (innate immune response, B cell proliferation) paired with multiple cytoskeletal assembly processes (podosome, lamellipodium, filopodium) and cell adhesion components (tight junctions). This suggests a cohesive role in immune cell trafficking and interactions, driven by dynamic cytoskeletal remodeling. The inclusion of axonogenesis and centrosome localization reflects shared cytoskeletal regulation mechanisms across development and immune cell behavior, supporting a unified theme of immune cell migration and structural remodeling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0060348","count":4},{"id":"GO:0002322","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0071803","count":3}]},{"hash":"2281240743728257352","title":"Spliceosome-Driven mRNA Splicing Regulation","description":"The cluster is dominated by GO terms for mRNA splicing via the spliceosome and regulation of splicing (both positive and negative), with related terms on splice-site recognition and polyadenylation, indicating a cohesive module of RNA processing control. The presence of regulatory ncRNA-mediated gene silencing and stress-related mRNA stability suggests broader post-transcriptional regulation linked to splicing.","confidence":"High","size":14,"edges":86,"triangles":310,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0010610","count":7},{"id":"GO:0000398","count":6},{"id":"GO:0006378","count":6}]},{"hash":"2061978469025606050","title":"Chorion formation and maternal mRNA regulation","description":"The top GO terms point to chorion-containing eggshell formation and multicellular development, while additional terms reflect mRNA splicing, stability, and translational control. Together these suggest a cluster of proteins involved in egg development and early embryogenesis, coordinating chorion formation with post-transcriptional regulation of maternal mRNAs.","confidence":"Medium","size":14,"edges":21,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0007304","count":6},{"id":"GO:0048026","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0006376","count":2}]},{"hash":"2148775102217448909","title":"RNA Splicing and Processing Machinery","description":"The cluster is dominated by GO terms for RNA processing and maturation, including mRNA splicing via the spliceosome, spliceosomal complex assembly, transcription termination, tRNA processing, and maturation of rRNA, plus P-body assembly. These collectively point to a cohesive role in RNA metabolism and post-transcriptional regulation, with a few peripheral terms (chromatin modification, ABA response) that may reflect broader nuclear or stress-related contexts. Overall, the set coherently centers on RNA splicing and processing functions.","confidence":"Medium","size":14,"edges":57,"triangles":108,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":8},{"id":"GO:0006369","count":7},{"id":"GO:0042633","count":7},{"id":"GO:0009414","count":7},{"id":"GO:0000245","count":7}]},{"hash":"1969034918529350637","title":"Ribosome Biogenesis and RNA Processing","description":"Most frequent GO terms center on ribosomal RNA maturation (LSU/SSU, 5.8S) and ribosomal large subunit biogenesis, indicating proteins involved in ribosome assembly. Spliceosome-associated terms and nuclear mRNA processing suggest broader RNA-processing roles, but the dominant signal is ribosome biogenesis and rRNA maturation. DNA replication/recombination terms appear ancillary. Likely a cluster of proteins coordinating ribosome assembly with RNA processing functions.","confidence":"","size":14,"edges":25,"triangles":0,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000463","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0048568","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0000466","count":3}]},{"hash":"1840048564704181409","title":"Spermatogenesis and RNA processing","description":"This cluster is dominated by spermatogenesis and spermatid development terms, implying a core theme of male germ cell development. It also includes RNA processing activities (splicing, ribosome export) that relate to gene expression in germ cells, while other terms hint at broader signaling roles; overall the reproductive development signal is most representative, though not exclusive.","confidence":"Low","size":14,"edges":20,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":3},{"id":"GO:0007286","count":3},{"id":"GO:1903026","count":2},{"id":"GO:0006955","count":2},{"id":"GO:0000398","count":2}]},{"hash":"2069721692918280495","title":"Metabolic stress and survival signaling","description":"This cluster shows a mix of energy production (ATP synthesis), multiple stress-response terms (hyperoxia, toxic substances, cadmium), and anti-apoptotic/metabolic regulation (cholesterol, insulin, cell division). The common theme is coordination of metabolism with cellular stress responses and survival, rather than a single precise pathway.","confidence":"Medium","size":14,"edges":19,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015986","count":2},{"id":"GO:0055093","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0051781","count":2},{"id":"GO:0014854","count":2}]},{"hash":"907478432695315853","title":"Neural development and transcriptional regulation","description":"The top GO terms cluster around neural development and gene expression control, including brain development, synaptic plasticity, transcriptional regulation, and mRNA processing. While some terms also touch on cell cycle/meiosis, the prominent neural development and transcription-related themes suggest a cohesive, brain-development\u2013oriented function. The lack of interactions within the cluster lowers confidence slightly, but the shared themes support this label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0007129","count":2},{"id":"GO:0051301","count":2}]},{"hash":"2127180898281623489","title":"Unknown","description":"The set mixes lipid metabolism (triglyceride metabolic process) and vitamin D signaling with several regulatory and chromatin-related terms, plus peroxisomal import and V(D)J recombination. The terms do not converge on a single clear biological function or pathway, so a specific, representative cluster name cannot be confidently assigned.","confidence":"","size":14,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0006641","count":4},{"id":"GO:2000620","count":3},{"id":"GO:0042981","count":3},{"id":"GO:0046328","count":3}]},{"hash":"1193255500993821412","title":"Unknown","description":"The top GO terms cover vesicle transport, DNA replication, glycolysis, transcription regulation, NF-kappaB signaling, chromatin processes, plant hormone biosynthesis, and various proliferation terms across different organisms, indicating a mixed, non-cohesive set rather than a single cohesive function. There isn\u2019t a clear common theme tying these proteins together, so a specific label is not supported.","confidence":"","size":14,"edges":10,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0072383","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0071320","count":2},{"id":"GO:0034244","count":2}]},{"hash":"770999498273988448","title":"Neural development and immune signaling","description":"The top GO terms include neural development (axon extension, neuron projection development, retina vasculature development) alongside immune signaling (Fc-epsilon receptor signaling, T cell receptor signaling), plus various development/metabolic terms. This suggests the proteins are involved in diverse signaling and developmental processes across tissues rather than a single cohesive function, yielding a label that reflects both neural development and immune signaling themes.","confidence":"Medium","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030517","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0071361","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0006641","count":3}]},{"hash":"134754396193550197","title":"Retroviral integration and latency","description":"The cluster centers on processes from the retroviral life cycle: entry into the host cell and nuclear penetration, reverse transcription (RNA-templated DNA synthesis), DNA integration, and establishment of integrated proviral latency, with DNA replication/recombination supporting viral genome propagation. These strongly linked GO terms point to retroviral infection and provirus maintenance as the unifying theme.","confidence":"High","size":14,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006310","count":5},{"id":"GO:0075732","count":4},{"id":"GO:0046718","count":4},{"id":"GO:1903704","count":4}]},{"hash":"1586391206533550787","title":"Transmembrane Nutrient Transporters","description":"The top GO terms are dominated by transmembrane transport activities for a diverse set of substrates (sugars, urate, sialic acid, vitamins, xenobiotics, etc.), plus related responses like glucose starvation. This points to a cluster of proteins that function primarily as membrane transporters for nutrients and related compounds.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005989","count":4},{"id":"GO:0015771","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0015747","count":3},{"id":"GO:0042149","count":3}]},{"hash":"479139782745684277","title":"Skeletal muscle development and sarcomere organization","description":"Among the top GO terms, multiple entries explicitly refer to sarcomere organization and skeletal muscle fiber development, supported by ubiquitin-dependent protein catabolic processes and K11-linked ubiquitination that commonly regulate muscle protein turnover. While other terms touch nervous system development or circadian processes, the strongest signal is muscle/cytoskeletal organization.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0007399","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0070979","count":3},{"id":"GO:0045214","count":3}]},{"hash":"862724282160003714","title":"Multitissue Differentiation Programs","description":"This cluster centers on GO terms related to differentiation across many tissues (neural, cardiovascular, muscle, plant, etc.), pointing to developmental differentiation processes rather than a single pathway; the presence of regulatory terms is supportive but the dominant theme is tissue-wide differentiation.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0061103","count":12},{"id":"GO:0060842","count":12},{"id":"GO:0021558","count":12},{"id":"GO:0045663","count":12},{"id":"GO:0048658","count":12}]},{"hash":"706093297181027907","title":"Cell division and intracellular transport","description":"This label captures the strongest signals in the cluster: several GO terms relate to cell cycle and division (mitotic sister chromatid separation, regulation of cell cycle, cell division), while others point to intracellular transport processes (proton transmembrane transport, ER-to-Golgi vesicle transport, mRNA transport). Together, they suggest a group of proteins that coordinate division with membrane and RNA transport. Some terms (root development, calcium-dependent adhesion, cardiac conduction regulation) are more peripheral and do not negate the core theme.","confidence":"Medium","size":14,"edges":22,"triangles":9,"max_degree":13,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":4},{"id":"GO:0051306","count":4},{"id":"GO:0007050","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0006888","count":4}]},{"hash":"2162192994353829506","title":"Drosophila Germline and Neural Development","description":"The top GO terms point to developmental processes across Drosophila tissues, including germline-related egg chamber formation and axis specification, as well as neural development like nerve maturation and signals related to myelination and cell adhesion. This suggests a cohesive theme of developmental morphogenesis and tissue differentiation in fruit flies, despite the terms spanning multiple tissues. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060445","count":4},{"id":"GO:0021682","count":4},{"id":"GO:0031643","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0051898","count":4}]},{"hash":"308977474333790745","title":"Chromatin remodeling and transcription regulation","description":"The top GO terms cluster around DNA-templated transcription, heterochromatin maintenance, nucleosome density, and histone deacetylation, indicating epigenetic control of gene expression. The inclusion of BMP-responsive transcription and negative regulation of differentiation supports a role for chromatin modifiers in coordinating transcriptional programs during lineage specification.","confidence":"High","size":14,"edges":83,"triangles":279,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0010832","count":6},{"id":"GO:0060766","count":6},{"id":"GO:0045668","count":6},{"id":"GO:0006344","count":5}]},{"hash":"1940012167325017626","title":"Embryonic neural development and organogenesis","description":"These proteins are enriched for neural lineage specification (spinal cord motor neurons, oligodendrocytes, cortical GABAergic interneurons, cranial nerve development) and other organogenesis pathways (bronchiole development, endocrine pancreas, carotid body, arterial endothelium). The common theme is embryonic development and cell fate decisions governed by transcriptional regulation, suggesting a broad developmental program rather than a single pathway.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0021520","count":10},{"id":"GO:0021530","count":10},{"id":"GO:0060163","count":10},{"id":"GO:0060435","count":10}]},{"hash":"376066003797254111","title":"Vesicle trafficking and TORC1 growth signaling","description":"The GO terms center on vesicle transport (Golgi-to-ER, mRNA transport), GTPase activity regulation, and TORC1 signaling, all connecting membrane trafficking to growth control. The developmental terms reflect growth phenotypes, but the core theme remains trafficking-linked growth signaling.","confidence":"Medium","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051028","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0070262","count":5},{"id":"GO:0038202","count":5},{"id":"GO:0015991","count":4}]},{"hash":"1368792909167782208","title":"Neuronal Axon Guidance and Adhesion","description":"This cluster is dominated by terms related to neural development, especially axonogenesis in the peripheral nervous system and motor neuron axon guidance, supplemented by cell-matrix adhesion which facilitates axon pathfinding. Although a few terms are unrelated or outdated, the strongest and most frequent signals point to neuronal axon development and ECM interactions.","confidence":"Medium","size":14,"edges":13,"triangles":3,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0048936","count":4},{"id":"GO:0008045","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0045150","count":3}]},{"hash":"589674222353190828","title":"Unknown","description":"The terms span immune signaling (T cell receptor signaling, LPS response, GM-CSF stimulus) and chemotaxis, plus neuronal development (dendrite morphogenesis) and general cell-cycle/ transcription processes (DNA-templated transcription, centriole replication, meiotic DSB processing); there isn\u2019t a single cohesive function tying all 14 proteins together, so the cluster appears functionally heterogeneous.","confidence":"","size":14,"edges":25,"triangles":13,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0046827","count":11},{"id":"GO:0006813","count":11},{"id":"GO:0050852","count":11},{"id":"GO:0097011","count":11}]},{"hash":"496923447331523798","title":"Retroviral DNA integration and latency","description":"The GO terms cluster around steps of retroviral infection: entry into the host nucleus, reverse transcription (RNA-templated DNA synthesis), DNA integration and replication, and establishment of proviral latency. Additional terms point to host-virus interactions such as suppression of RNA silencing and host apoptosis modulation, reinforcing a retroviral life cycle theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0006310","count":2},{"id":"GO:1903704","count":2}]},{"hash":"1330222203088501520","title":"Flavonoid biosynthesis and transcription regulation","description":"This cluster is enriched for plant-specific flavonoid biosynthesis terms, notably anthocyanin-containing compound biosynthetic process and kaempferol O-glucoside biosynthetic process, indicating a flavonoid production theme. Additionally, transcription-related terms (negative regulation of transcription by RNA polymerase II, DNA-templated transcription) suggest regulatory roles accompanying these biosynthetic pathways. A few outlier terms (e.g., heart development, estrogen catabolic process) likely reflect cross-species or broad annotations and do not override the main flavonoid/transcription pattern.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0009718","count":3}]},{"hash":"499683553378653336","title":"Unknown","description":"The top GO terms are highly diverse, including xenobiotic response, ribosomal subunit export, osmotic stress, transcription initiation, retinal development, lipid and vitamin biosynthesis, and post-translational modification, with no clear shared function linking the proteins. The cluster also has no edges or triangles, indicating little direct functional connectivity. As a result, there isn\u2019t a coherent theme to label this cluster with a specific function.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":4},{"id":"GO:1903206","count":3},{"id":"GO:0000056","count":3},{"id":"GO:0006972","count":3},{"id":"GO:0015074","count":2}]},{"hash":"293815051943383170","title":"DNA Repair and Genome Maintenance","description":"This cluster is dominated by nucleic acid\u2013related GO terms, especially DNA recombination and base-excision repair, indicating a primary role in genome maintenance and DNA repair processes. Additional signals related to redox and xenobiotic responses may reflect parallel stress-related pathways but do not override the core repair-focused theme.","confidence":"High","size":14,"edges":54,"triangles":93,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":12},{"id":"GO:1903507","count":11},{"id":"GO:0046856","count":11},{"id":"GO:2000466","count":11},{"id":"GO:0042493","count":11}]},{"hash":"1699562346470449988","title":"Vesicle trafficking and synaptic signaling regulation","description":"This cluster is driven by GO terms emphasizing regulation of endocytosis and exocytosis (positive regulation of receptor-mediated endocytosis; regulation of synaptic vesicle exocytosis) and synaptic transmission, especially glutamatergic signaling, suggesting a core role in vesicle trafficking and neuronal communication. Additional terms point to related signaling regulation (GTPase activity, PI dephosphorylation). A few outliers (mismatch repair, tRNA processing, ABA signaling) exist but do not override the central vesicle trafficking/synaptic theme.","confidence":"Medium","size":14,"edges":22,"triangles":10,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048260","count":2},{"id":"GO:0051642","count":2},{"id":"GO:0035249","count":1},{"id":"GO:0046580","count":1},{"id":"GO:0060304","count":1}]},{"hash":"1687670647100884181","title":"Coagulation, fibrinolysis, and innate immune response","description":"The top GO terms cluster around blood coagulation and fibrinolysis (Factor XII activation, plasminogen activation, fibrinolysis), complement activation, and endothelial barrier remodeling, with neutrophil-mediated antimicrobial functions. This points to a cohesive theme of coagulation/vascular remodeling in tandem with innate immunity, despite one transcription regulation term.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:1903142","count":3},{"id":"GO:0070947","count":3},{"id":"GO:0002542","count":3},{"id":"GO:0048771","count":3}]},{"hash":"297384788370931285","title":"Fatty acid transport and metabolism","description":"The dominant GO terms point to uptake/transport of fatty acids (long-chain and medium-chain) and their subsequent metabolism, including long-chain fatty acid import into the cell and related metabolic processes, with lipoteichoic acid biosynthesis hinting at a bacterial lipid-envelope context. While there are a few outliers (e.g., seed germination, bile acid metabolism), the core signal is lipid transport and lipid metabolism, suggesting a cluster of proteins involved in lipid acquisition and processing in a bacterial setting.","confidence":"Medium","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":5},{"id":"GO:0015911","count":4},{"id":"GO:0090410","count":4},{"id":"GO:0010030","count":4},{"id":"GO:0001579","count":4}]},{"hash":"2280847705278343593","title":"Unknown","description":"The top GO terms span both metabolism (malate, lipid/steroid biosynthesis, nucleotide catabolism) and core gene expression processes (translation, tRNA aminoacylation, DNA-templated transcription, DNA repair) plus signaling, with no clear single theme or interaction pattern linking them. The absence of edges and the diverse functional terms support treating this as an Unknown cluster.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006108","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006438","count":2},{"id":"GO:0006694","count":2},{"id":"GO:0009154","count":2}]},{"hash":"822965391968307826","title":"Retinoid signaling and lipid metabolism","description":"This cluster centers on retinoic acid signaling and lipid-related pathways, including vitamin A metabolism, regulation of retinoic acid receptor signaling, phosphatidylcholine biosynthesis, fatty acid oxidation regulation, cholesterol and prostaglandin biosynthesis, and developmental contexts like eye and genital morphogenesis, which can be influenced by retinoid signaling. The presence of additional regulatory terms (e.g., negative regulation of protein kinase activity) complements signaling and metabolic themes rather than a single isolated function.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":1},{"id":"GO:0048385","count":1},{"id":"GO:0006656","count":1},{"id":"GO:0001654","count":1},{"id":"GO:2000778","count":1}]},{"hash":"2113567909988254286","title":"Cholesterol transport and lipid metabolism","description":"The majority of top GO terms point to lipid handling, including cholesterol transport/remodeling, cholesterol homeostasis, triglyceride catabolism, and lipoprotein metabolic regulation, indicating proteins in this cluster are tied to lipid metabolism and cholesterol management. Some terms like antibiotic/biotin biosynthesis and chemokine regulation appear, but they are less representative of the cluster's core function. Overall, this cluster seems best described as focused on cholesterol transport and lipid metabolism.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0032376","count":3}]},{"hash":"1181633937255520909","title":"Cell Architecture and Polarity","description":"The top GO terms cluster around how cells maintain and organize their shape and structure\u2014cell adhesion, polarity, and cytoskeletal organization (including sarcomere assembly and mitotic spindle components). This suggests a focus on cellular architecture and the regulation of cell shape. Some terms are obsolete or relate to redox processes or tissue-specific maintenance, which do not fit as cleanly with the core theme, so the main signal is structural organization. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0071963","count":3}]},{"hash":"2020086772267252227","title":"Oxidative Stress Response","description":"The top GO terms cluster around redox biology and cellular stress (oxidation-reduction, superoxide generation, response to toxic substances, and cellular stress responses to acidic pH). Although some terms appear unrelated (transcription/repair or antibiotic biosynthesis), the common thread is a cellular response to oxidative or toxic stress, suggesting a redox/stress-response theme for this protein set.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009636","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0006360","count":1},{"id":"GO:0006289","count":1}]},{"hash":"864976587443202355","title":"Coagulation and inflammation signaling","description":"Dominated by blood coagulation and inflammatory mediator production, with additional cues from cell-matrix adhesion and metabolic responses. The GO terms suggest a theme around wound healing and coagulation\u2013inflammation cross-talk, though some signals point to stress- and metabolism-related processes, making the connection broader rather than tightly cohesive.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0071333","count":3},{"id":"GO:0007160","count":3},{"id":"GO:0051436","count":2},{"id":"GO:0008285","count":2}]},{"hash":"996832506899748399","title":"Phospholipid Biosynthesis and Lipid Signaling","description":"The top GO terms cluster around membrane lipid metabolism, with multiple biosynthetic processes for phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol, plus related biosynthesis and signaling (including platelet activating factor). There is also a note of regulation of GTPase activity, which can tie to membrane trafficking and signaling. A couple of terms about cuticle pigmentation and male mating behavior appear but are peripheral to the main lipid-focused signal. Overall, the cluster appears to reflect membrane lipid biosynthesis and related signaling pathways.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":2},{"id":"GO:1905711","count":2},{"id":"GO:0006659","count":2},{"id":"GO:0010512","count":2},{"id":"GO:0006646","count":2}]},{"hash":"398003787265721288","title":"Post-transcriptional mRNA processing and translation control","description":"These terms cluster around RNA maturation and regulation: spliceosome-mediated splicing, splice-site recognition, and mRNA polyadenylation/stability; plus regulatory ncRNA silencing and translation initiation/reinitiation (including IRES). This points to a cohesive role in post-transcriptional mRNA processing and control of gene expression.","confidence":"High","size":13,"edges":63,"triangles":193,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0010610","count":9},{"id":"GO:0045292","count":9},{"id":"GO:1901407","count":9}]},{"hash":"2055118069334064533","title":"Diverse Substrate Membrane Transport","description":"The top GO terms point to transport across the plasma membrane for a wide range of substrates (trehalose, urate, fructose, sialic acid, phosphate, vitamins, selenite, organic anions) and a cellular response to glucose starvation, indicating a function centered on membrane transporters with broad substrate specificity. This cluster likely groups proteins that facilitate diverse substrate uptake/efflux rather than a single specific substrate pathway.","confidence":"High","size":13,"edges":38,"triangles":50,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":5},{"id":"GO:0006855","count":5},{"id":"GO:0015747","count":5},{"id":"GO:0042149","count":5},{"id":"GO:1990539","count":5}]},{"hash":"466129474146272918","title":"Diverse solute transmembrane transporters","description":"Most GO terms point to transmembrane transport of diverse solutes (xenobiotics, vitamins, sialic acid, phosphate, nitrate, sodium, nitrate assimilation, fucose) and even a neurotransmitter loading process, suggesting a cluster of membrane transport proteins with broad substrate specificity. A single outlier term on larval cuticle development is less central to the common theme. Overall, the key shared function is transporter activity across membranes for various solutes. ","confidence":"Medium","size":13,"edges":14,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0006855","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0035435","count":2}]},{"hash":"221377088852985793","title":"Amino acid and cofactor biosynthesis","description":"The top GO terms point to multiple biosynthetic pathways (lysine, glutamine/glutamate, biotin, porphyrinogen) and central metabolism (TCA cycle), along with a starvation response. This pattern suggests a cluster enriched for metabolic biosynthesis activities and energy-related processes rather than a single, narrow function, indicating a cohesive metabolism-focused group.","confidence":"Medium","size":13,"edges":46,"triangles":68,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":4},{"id":"GO:0006099","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006541","count":2}]},{"hash":"2040429239124281088","title":"Stress and metabolic responses","description":"These proteins appear to participate in a broad set of stress-related and metabolic processes. The top GO terms include responses to cold, lipopolysaccharide, fungicide, and selenium ion, indicating environmental and chemical stress responses. Alongside these, metabolic-focused terms such as guanine metabolism and L-proline catabolic process, plus tRNA wobble uridine modification, suggest coordinated regulation of metabolism and translation under stress. A few terms also touch on cell growth and dopamine metabolism, implying a wider regulatory network rather than a single pathway. Overall, the cluster seems to reflect diverse stress-responsive and metabolic functions rather than a unique, cohesive module.","confidence":"Medium","size":13,"edges":9,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009409","count":3},{"id":"GO:0016049","count":2},{"id":"GO:0002098","count":2},{"id":"GO:0046098","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1671038640010900280","title":"Unknown","description":"The terms span disparate areas: several carbohydrate and amino acid catabolic pathways, alongside processes like mitochondrial translation and endoplasmic reticulum organization, with no single cohesive function tying them all together. Therefore there isn\u2019t a clear, representative label for this cluster.","confidence":"","size":13,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009089","count":3},{"id":"GO:0070681","count":3},{"id":"GO:0007029","count":3},{"id":"GO:0019876","count":3},{"id":"GO:0009062","count":3}]},{"hash":"1179329344655072043","title":"Ciliary assembly and Hedgehog signaling","description":"The top GO terms heavily point to cilia-related functions: intraflagellar transport, cilium assembly, and Smoothened signaling, which together implicate ciliogenesis and ciliary Hedgehog signaling as the core theme of this cluster. A few other terms (e.g., cuticle development, various biosynthetic processes) appear only once or twice and may reflect annotation noise or incidental associations. Overall, the dominant signal supports a cilia-centric function.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0042073","count":1},{"id":"GO:0060271","count":1},{"id":"GO:0007224","count":1},{"id":"GO:0015940","count":1}]},{"hash":"628832694824702603","title":"Gene expression and mitochondrial maintenance","description":"This cluster is driven by core gene expression processes (DNA-templated transcription and translation) and is complemented by signals related to mitochondrial dynamics (positive regulation of mitochondrial fusion) and protein turnover (regulation of proteasomal ubiquitin-dependent degradation). The presence of biosynthetic GO terms for cofactors like biotin and porphyrin further supports a theme around fundamental cellular metabolism linked to gene expression and mitochondrial function. Overall, the proteins appear to participate in basic transcription/translation together with mitochondrial maintenance and proteostasis.","confidence":"Medium","size":13,"edges":30,"triangles":42,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0019551","count":3},{"id":"GO:0006782","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0009102","count":3}]},{"hash":"1777186132940729076","title":"Plasma Membrane Solute Transporters","description":"These proteins share a clear theme of transporting diverse solutes across the plasma membrane, including sugars, urate, vitamins, sialic acid, phosphate, xenobiotics, and organic anions, as reflected by the GO terms for transmembrane transport. The presence of multiple substrate-specific transport terms together with a general transport context supports labeling the cluster as membrane transporters rather than a single substrate family. High","confidence":"","size":13,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":13},{"id":"GO:0006855","count":13},{"id":"GO:0015747","count":13},{"id":"GO:0042149","count":13},{"id":"GO:1990539","count":13}]},{"hash":"2295301393525722894","title":"Ribosome biogenesis and translation","description":"The cluster is enriched for translation- and ribosome-related functions, including cytosolic and mitochondrial translation, ribosome biogenesis, and subunit assembly, indicating a cohesive module of ribosomal proteins and biogenesis factors involved in protein synthesis. The presence of fidelity regulation and ribosome assembly terms supports a focus on ribosomal production and function (with antibiotic response reflecting ribosome-targeting effects). ","confidence":"High","size":13,"edges":71,"triangles":220,"max_degree":12,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0002181","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0006450","count":3},{"id":"GO:0032543","count":2}]},{"hash":"1897352715115021528","title":"Transcription, mRNA Export, and Translation Regulation","description":"The cluster's GO terms cluster around transcription and translation control (translation, positive regulation of transcription elongation by RNA polymerase II, RNA pol II promoter clearance), plus mRNA export and regulation of translation, indicating a cohesive role in gene expression from transcription through RNA processing/export to translation. Minor terms about cell cycle and virus response exist but do not override the central theme.","confidence":"High","size":13,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0002181","count":1},{"id":"GO:0045787","count":1}]},{"hash":"549151993666530587","title":"Calcium Signaling in Muscle and Neural Development","description":"These proteins appear to participate in calcium signaling across multiple tissues, linking calcium transport/detection to muscle and heart development and to neural activity (excitation, memory). The presence of skeletal muscle development, regulation of cardiac contraction, and neural terms like long-term memory and excitatory postsynaptic potential suggests a shared theme of Ca2+-mediated modulation of muscle/heart function and neural development, with some broader developmental processes also represented.","confidence":"High","size":13,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006816","count":3},{"id":"GO:0005513","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0072221","count":3},{"id":"GO:0060079","count":3}]},{"hash":"1605115596623732703","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by translation-related processes (translation, cytoplasmic translation, ribosome biogenesis, ribosomal large subunit assembly), indicating proteins primarily involved in the protein synthesis machinery. Secondary terms for mitochondrial electron transport and photosynthesis are less coherent with this core theme, likely reflecting dual-localized or broadly annotated proteins. ","confidence":"Medium","size":13,"edges":8,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006015","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0019684","count":2}]},{"hash":"2097287296545706209","title":"Organogenesis and tissue development","description":"These GO terms cluster around development of diverse organs and tissues (gonads, uterus, digestive tract, phloem, neurons) and processes like cell-matrix adhesion and hippo signaling regulation. The common theme is broad organogenesis/tissue development across multiple lineages, rather than a single pathway or tissue. ","confidence":"Medium","size":13,"edges":14,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":10},{"id":"GO:0048565","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0055011","count":5},{"id":"GO:0035331","count":5}]},{"hash":"1084115634046242203","title":"Skin barrier and stress response","description":"These terms cluster around skin-related differentiation (corneocyte development) and cellular stress responses, including redox balance and xenobiotic response; base-excision repair supports genome maintenance in exposed skin cells, while signaling-related terms (phosphatidylinositol dephosphorylation, peptide hormone response) flank these processes. Overall, the proteins appear linked to skin barrier function and stress response, though some terms are obsolete in current ontologies, suggesting heterogeneous or noisy annotations.","confidence":"Medium","size":13,"edges":13,"triangles":1,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:1903507","count":4},{"id":"GO:0046856","count":4},{"id":"GO:2000466","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0090502","count":4}]},{"hash":"2041069183907585716","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms for ribosome biogenesis (small and large subunits), cytoplasmic translation, tRNA modification, and ribosomal subunit export, pointing to a core ribosome assembly and protein synthesis function; cell cycle/division terms may reflect growth coordination but do not outweigh the translation-centric signals.","confidence":"High","size":13,"edges":14,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0090529","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000055","count":2}]},{"hash":"569671734882598928","title":"Insect development and eggshell formation","description":"This cluster is dominated by GO terms related to insect development, including metamorphosis and chorion-containing eggshell formation, with supporting multicellular development signals. While a set of catabolic processes appears, the strongest pattern centers on development and eggshell formation typical of insects, justifying the label as an insect developmental/egg-shell cluster.","confidence":"Medium","size":13,"edges":15,"triangles":7,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042838","count":1},{"id":"GO:0019262","count":1},{"id":"GO:0046176","count":1},{"id":"GO:0009089","count":1},{"id":"GO:0019470","count":1}]},{"hash":"1178338116096679787","title":"RNA processing and ribosome maturation","description":"This cluster is driven by RNA-centric functions: multiple terms for rRNA maturation (SSU, 5.8S, LSU) from tricistronic transcripts and spliceosome-mediated mRNA splicing, indicating a shared role in RNA maturation and ribosome biogenesis. Other terms (lens fiber differentiation, neuron projection development, T cell proliferation, actin regulation, ubiquitin ERAD, chromatin assembly) appear ancillary, but do not override the central RNA-processing theme.","confidence":"Medium","size":13,"edges":25,"triangles":6,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0034316","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0042102","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0070306","count":2}]},{"hash":"548124164817645808","title":"Neuronal signaling and cytoskeletal dynamics","description":"The top terms cluster around regulation of MAPK cascades (ERK/JNK), Wnt signaling, nervous system development, and long-term synaptic plasticity, combined with actin filament branching and podosome assembly. This points to proteins coordinating signaling pathways with cytoskeletal remodeling in neurons and related contexts, rather than a single pathway or non-neuronal process. ","confidence":"High","size":13,"edges":8,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0043525","count":6},{"id":"GO:0007399","count":6}]},{"hash":"1129820382232850953","title":"Neuronal development and synaptic signaling","description":"This cluster is enriched for neural development and function terms (axonogenesis, Schwann cell development, long-term synaptic potentiation, visual perception) and also includes broader developmental processes like myoblast fusion and heart development, suggesting a shared theme of developmental programs spanning neural and muscular tissues with emphasis on neural signaling. Some terms (e.g., abscisic acid-activated signaling) appear less related and may reflect annotation noise.","confidence":"Medium","size":13,"edges":63,"triangles":171,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007520","count":11},{"id":"GO:0060291","count":11},{"id":"GO:0043065","count":11},{"id":"GO:0009738","count":11},{"id":"GO:0010800","count":10}]},{"hash":"2010409714167750329","title":"Cerebellar development and axon regeneration","description":"The cluster\u2019s top GO terms center on cerebellar-specific development and neural support: cerebellar cortex formation, Bergmann glial cell differentiation, and regulation of axon regeneration. While other signaling-related terms appear, the strongest signals tie to cerebellar neuronal development and glial differentiation, suggesting a cohesive theme around cerebellar growth, wiring, and glial support. Confidence: High","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048679","count":3},{"id":"GO:0021697","count":3},{"id":"GO:0033630","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0050852","count":3}]},{"hash":"234268044158832459","title":"Organogenesis","description":"The top GO terms describe development and morphogenesis across multiple organs (bone via osteoblast development; retina/eye; heart and outflow tract; placenta; prostate; habenula), plus myoblast proliferation, indicating a shared theme of organ formation rather than a single tissue process.","confidence":"High","size":13,"edges":53,"triangles":88,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002076","count":8},{"id":"GO:0060041","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0002087","count":8},{"id":"GO:0060527","count":7}]},{"hash":"1018024994568470798","title":"Vascular development and inflammatory regulation","description":"The cluster\u2019s terms center on multicellular development, vascular and renal regulation (blood pressure, renal sodium excretion, coagulation), and immune signaling (IL-8 production, monocyte chemotaxis), suggesting a theme of vascular development/remodeling integrated with immune and systemic regulation during pregnancy and tissue remodeling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0045777","count":2},{"id":"GO:2000484","count":2},{"id":"GO:0090026","count":2},{"id":"GO:0007202","count":2}]},{"hash":"1337774101215446749","title":"Embryonic Mesoderm and Organogenesis","description":"This cluster centers on developmental processes during embryogenesis, with several GO terms pointing to mesoderm formation, tissue morphogenesis (cartilage, heart cushions), axis patterning (left/right), and organ development (pancreatic/endocrine systems, placenta). A couple of terms (mRNA splicing and vitamin D regulation) may reflect broader cellular regulation, but the dominant theme is embryonic development and mesoderm-derived organogenesis.","confidence":"Medium","size":13,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0060707","count":5}]},{"hash":"1764178247745671074","title":"Notch receptor processing and gamma-secretase activity","description":"The cluster\u2019s top GO terms cluster around Notch signaling and proteolysis of membrane proteins, especially Notch receptor processing via ectodomain and intracellular domain proteolysis. These processes are classically driven by gamma-secretase, which also links to amyloid-beta formation. Additional terms for pharynx development and synaptic/membrane organization fit broader developmental and neural contexts, but the core theme is intramembrane proteolysis activating Notch signaling.","confidence":"High","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034205","count":1},{"id":"GO:0060465","count":1},{"id":"GO:0006509","count":1},{"id":"GO:0031293","count":1},{"id":"GO:0007219","count":1}]},{"hash":"1048014625467374369","title":"Unknown","description":"The top GO terms span mechanical response, cell-cycle regulation, transcriptional repression, NF-kappaB signaling, NOD2 signaling, Notch signaling in heart development, and general multicellular processes, plus chromosomal localization. The terms reflect diverse, possibly incidental processes rather than a single shared function, so no clear common function emerges.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0032088","count":1},{"id":"GO:0070431","count":1}]},{"hash":"1862942172704283455","title":"Cell cycle control and transcription regulation","description":"The top GO terms are heavily centered on cell cycle dynamics (G1/S and G2/M transitions, spindle separation, CDK activity) and transcriptional processes (DNA-templated transcription). This suggests the cluster proteins jointly regulate cell division and gene expression, with some additional proliferation signals noted in mammary tissue and immune contexts.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045737","count":3},{"id":"GO:0046638","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0033598","count":2}]},{"hash":"643852739478832235","title":"Proteasome-Mediated Degradation in Oocyte Meiosis","description":"The cluster\u2019s top GO terms center on ubiquitin-dependent protein catabolic processes, SCF-dependent proteasomal pathways, and meiosis/oocyte maturation, with related processes like spindle assembly and microtubule polymerization. This pattern suggests a cohesive role in regulated proteolysis controlling meiotic progression and spindle dynamics in oocytes, with some developmental terms reflecting broader proteostatic roles in development. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0021993","count":7},{"id":"GO:0007057","count":7},{"id":"GO:0021678","count":7},{"id":"GO:0051436","count":7}]},{"hash":"2081841783065662708","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around embryonic development, tissue morphogenesis, axis formation, and lineage specification (including endocrine development, placental and trophoblast-related terms, epithelial-to-mesenchymal transitions, cartilage morphogenesis, and germ-line axis formation), suggesting a shared theme of developmental processes across tissues and species. This makes \u201cEmbryonic development and morphogenesis\u201d a representative and specific label for the group.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060536","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0060707","count":7}]},{"hash":"601303482204981964","title":"Antennal/Eye Development and Nuclear RNA Processing","description":"This cluster centers on antennal and compound eye development alongside transcription regulation and spliceosome-associated RNA processing, indicating proteins involved in nuclear gene expression control during sensory organ development. While a few catabolic RNA terms appear, the dominant signals point to development-linked transcription and RNA processing.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007469","count":2},{"id":"GO:0045316","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000244","count":1}]},{"hash":"1252117268368317943","title":"Neurodevelopment and Axon Guidance","description":"The cluster is dominated by neural development terms (nervous system development, neurogenesis, retina morphogenesis) and axon guidance (Roundabout signaling pathway), suggesting a function in neural differentiation and neural circuit formation. Additional terms such as heart and reproductive development, cell cycle, apoptosis, and T cell signaling indicate broader developmental processes, but the strongest cohesive theme is neurodevelopment and axon guidance.","confidence":"Medium","size":13,"edges":67,"triangles":190,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":6},{"id":"GO:0006915","count":5},{"id":"GO:0060068","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0050852","count":4}]},{"hash":"1714178575803801893","title":"Proviral Integration and Latency","description":"I named it Proviral Integration and Latency because the terms cluster around viral entry and integration into the host genome, establishment of proviral latency, and associated DNA recombination/replication processes, with additional hints of host RNAi modulation\u2014together indicating retroviral-like genome integration and persistence in the host.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075732","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0006278","count":4}]},{"hash":"2121465112019001399","title":"Diverse metabolite biosynthesis","description":"The cluster includes GO terms for biosynthetic and metabolic processes across pigments (melanin), antibiotics, plant alkaloids (tropane alkaloids), biopolymers (polyhydroxybutyrate), and lipid metabolism (3-keto-sphinganine), suggesting a unifying theme of producing diverse metabolites rather than a single pathway. Some outliers (regulation of transcription, lung development) may reflect cross-species annotations but do not dominate the set.","confidence":"Medium","size":13,"edges":55,"triangles":165,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0045150","count":11},{"id":"GO:0042619","count":11},{"id":"GO:0055114","count":11},{"id":"GO:0042438","count":11},{"id":"GO:0006355","count":11}]},{"hash":"135703493014140682","title":"Viral integration and proviral latency","description":"The cluster shows strong signals for viral/symbiont interactions with the host genome: entry into host cells and nucleus, DNA integration and recombination, and establishment of proviral latency, alongside related transcriptional regulation and genome-templated processes. These converging terms suggest a cohesive theme of viral genome integration and latency in the host. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006559","count":2},{"id":"GO:0075732","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0006310","count":1}]},{"hash":"1055781000976897711","title":"Membrane Trafficking and Localization in Development","description":"The cluster\u2019s GO terms center on protein localization to membranes and trafficking processes (Golgi localization, endocytosis, and regulation of localization to the plasma membrane), with supporting developmental signals (erythrocyte differentiation, neuron migration, and growth) and neural communication. This suggests a common theme of membrane trafficking/localization coordinating development and neural function, rather than a single cohesive pathway.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060319","count":1},{"id":"GO:0060391","count":1},{"id":"GO:0090005","count":1},{"id":"GO:1905602","count":1},{"id":"GO:2000379","count":1}]},{"hash":"1374026144742496789","title":"Actin-Mediated Neuronal Differentiation and Morphogenesis","description":"The cluster is enriched for actin cytoskeleton terms (actin filament assembly/depolymerization) and several development-related processes, notably neuronal differentiation and migration (midbrain dopaminergic neuron differentiation, spinal cord association neuron differentiation, lateral motor column neuron migration) plus various morphogenetic events (haltere, renal vesicle morphogenesis) and mRNA localization. This suggests a common theme of actin-driven remodeling guiding development and neuronal differentiation across tissues.","confidence":"Medium","size":13,"edges":25,"triangles":29,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":5},{"id":"GO:0097477","count":5},{"id":"GO:1904948","count":5},{"id":"GO:0070527","count":5},{"id":"GO:0048735","count":4}]},{"hash":"1062791718067043343","title":"Alcohol and sugar-aldehyde metabolism","description":"Top GO terms point to metabolism and catabolism of sugar alcohols (xylitol, sorbitol), alcohols (ethanol, retinol-related processes), and aldehydes (formaldehyde, furaldehyde), suggesting a cohesive module for detoxification and processing of alcohols and aldehydes, with broader carbohydrate metabolism context.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042572","count":6},{"id":"GO:0046370","count":6},{"id":"GO:0032496","count":5},{"id":"GO:0003016","count":5}]},{"hash":"1165863215965010317","title":"Prostaglandin Biosynthesis and Inflammatory Regulation","description":"This cluster is anchored by a strong signal for prostaglandin biosynthesis (GO:0001516) and inflammation-related regulation, including negative regulation of IL-1\u03b2 production and ERK cascade modulation, which point to lipid mediator\u2013driven inflammatory control. Other terms like cellular response to insulin, xenobiotic metabolism, and protein glutathionylation suggest supporting metabolic and redox context, but prostaglandin production and inflammatory signaling dominate.","confidence":"Medium","size":13,"edges":64,"triangles":165,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":12},{"id":"GO:0042178","count":7},{"id":"GO:1902476","count":7},{"id":"GO:0070373","count":7},{"id":"GO:0032869","count":7}]},{"hash":"2218319103852421078","title":"Glutamatergic Synaptic Transmission","description":"The cluster is driven by terms tied to excitatory synaptic signaling, especially glutamatergic transmission, membrane depolarization, and ion transport that shapes excitatory postsynaptic potentials. The presence of sodium and potassium transmembrane transport and the excitatory postsynaptic potential supports a neuronal signaling theme, while receptor recycling and endosome size regulation point to synaptic receptor trafficking. Although one term touches DNA-templated transcription and another mechanosensory detection, the dominant pattern corresponds to glutamatergic synaptic function.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0050910","count":2},{"id":"GO:0051899","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0060079","count":2}]},{"hash":"383811630564765482","title":"Coagulation and Immune Response","description":"The top GO terms are dominated by blood coagulation, fibrinolysis, acute-phase and defense responses to bacteria and yeast, suggesting a systemic inflammatory/immune program. While there are outliers like digestion and myelination, the most representative themes point to coagulation and immune defense, indicating proteins associated with circulating plasma responses rather than a single pathway. Therefore, a concise label 'Coagulation and Immune Response' captures the cluster's core functions.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007586","count":4},{"id":"GO:0007596","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0001878","count":3}]},{"hash":"439177818406614679","title":"Developmental Regulation and Organogenesis","description":"The top GO terms emphasize heart development, organ induction, odontogenesis, and other tissue-specific developmental processes, together with DNA-templated transcription and spliceosomal snRNP assembly, indicating a theme of gene expression regulation during organ and tissue formation. Some terms like chemokine production and satellite cell proliferation are ancillary but still fit within broader developmental/differentiation contexts, supporting a label focused on developmental regulation across organs rather than a single tissue. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0001759","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0000387","count":1}]},{"hash":"2065599661928940201","title":"Neural development and synaptic plasticity","description":"The top GO terms indicate neural processes: long-term synaptic potentiation, excitatory postsynaptic potentials, axonogenesis, visual perception, and Schwann cell development point to neuronal growth, connectivity, and synaptic function. Some terms like mitotic cell cycle and basic cell cycle transitions are present but appear incidental; overall, the cluster centers on neuronal development and synaptic signaling.","confidence":"High","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060291","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0060079","count":5}]},{"hash":"104963510446804362","title":"Vascular inflammation and coagulation activation","description":"The top GO terms cluster around immune and coagulation processes (endothelial barrier establishment, neutrophil-mediated killing, complement activation, Factor XII activation, fibrinolysis) and tissue remodeling, pointing to inflammatory vascular responses and coagulation cascades. Transcription regulation terms are present but less indicative of the core function. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":4},{"id":"GO:1903142","count":3},{"id":"GO:0070947","count":3},{"id":"GO:0002542","count":3},{"id":"GO:0048771","count":3}]},{"hash":"211180492614550946","title":"mRNA Splicing and Translation Regulation","description":"These proteins cluster around RNA processing and control of gene expression at the RNA level: several terms describe mRNA splicing via the spliceosome and splice-site recognition; others involve mRNA stability, poly(A) tail regulation, and regulation of translational initiation, including IRES-dependent initiation and translation reinitiation. The shared theme is post-transcriptional processing and regulation of translation, suggesting a functional module coordinating RNA processing with translation.","confidence":"High","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0045292","count":5},{"id":"GO:0075522","count":4},{"id":"GO:0006376","count":4}]},{"hash":"894679491405007583","title":"RNA processing and stress-responsive translation control","description":"The cluster centers on RNA processing and post-transcriptional regulation, including mRNA splicing (spliceosome, splice site recognition, splicing regulation), mRNA stability and poly(A) tail dynamics, mRNA stabilization, and translation control (translation reinitiation and IRES-dependent initiation), with context of cellular stress such as hypoxia. This combination suggests a cohesive role in coordinating RNA processing with translation during stress.","confidence":"High","size":12,"edges":53,"triangles":126,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":6},{"id":"GO:0045292","count":5},{"id":"GO:0071456","count":5},{"id":"GO:0048026","count":4},{"id":"GO:0075522","count":4}]},{"hash":"1870629727521768072","title":"Diverse membrane solute transporters","description":"The top GO terms show transport across membranes for a wide range of substrates (xenobiotics, vitamins, sugars, ions) and a vesicular neurotransmitter loading process, indicating this cluster comprises membrane transporter proteins with broad substrate specificity or involvement in vesicular transport rather than a single substrate pathway.","confidence":"High","size":12,"edges":36,"triangles":47,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":6},{"id":"GO:0035461","count":6},{"id":"GO:0015739","count":6},{"id":"GO:0035435","count":6},{"id":"GO:0098700","count":6}]},{"hash":"2094935193930903514","title":"Gene regulation and developmental signaling","description":"These terms point to a regulatory cluster: RNA processing (spliceosome assembly, mRNA transport), cell cycle/growth (mitotic cycle, proliferation), and signaling in neural and muscular contexts (synaptic plasticity, long-term potentiation, cardiac contraction regulation), with developmental cues (cuticle development). The common thread is gene expression and signaling regulation across development and neural systems, rather than a single cohesive function.","confidence":"Medium","size":12,"edges":10,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0051028","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1572562919135793207","title":"Diverse Plasma Membrane Solute Transporters","description":"The GO terms are dominated by transmembrane transport across the plasma membrane for a wide range of substrates (trehalose, urate, phosphate, sialic acid, vitamins, sugars, xenobiotics, selenite, organic anions), indicating a cluster of transport proteins with broad substrate specificity rather than a single substrate pathway.","confidence":"High","size":12,"edges":28,"triangles":24,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":8},{"id":"GO:0006855","count":8},{"id":"GO:0015747","count":8},{"id":"GO:0042149","count":8},{"id":"GO:1990539","count":8}]},{"hash":"1196216459135224658","title":"Mitotic progression and ubiquitin-proteasome regulation","description":"The proteins in this cluster are tightly linked to mitosis control (exit from mitosis, G2/M transition, chromosome segregation) and chromatin organization, with a strong emphasis on proteasome-mediated degradation (SCF-dependent, K48-linked ubiquitination). The presence of nucleotide-excision repair also suggests coordination of DNA maintenance with cell-cycle progression. The viral process term is likely ancillary, but the dominant theme is mitotic regulation and proteostasis.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0010458","count":12},{"id":"GO:0007059","count":12},{"id":"GO:0070911","count":12},{"id":"GO:0016032","count":12},{"id":"GO:0031146","count":12}]},{"hash":"113990032235197871","title":"Fatty acid oxidation and energy metabolism","description":"The top GO terms cluster around beta-oxidation pathways (acyl-CoA dehydrogenase/oxidase), long-chain fatty acid catabolism, and carnitine metabolism, with related energy-homeostasis processes such as regulation of gluconeogenesis and starvation response. A couple of terms (DNA replication, cardiac muscle differentiation) are less tightly connected, but the dominant signal is fatty-acid\u2013driven energy metabolism.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0033539","count":2},{"id":"GO:0019254","count":2},{"id":"GO:0042758","count":2}]},{"hash":"1645273810921020979","title":"Ion Transport and Vacuolar Trafficking","description":"The terms cluster around proton and sodium transport across membranes, proton motive force\u2013driven ATP synthesis, vacuolar acidification and vacuole organization, and protein targeting to vacuole, with some energy metabolism signals (TCA cycle). This suggests a cohesive module of membrane transport linked to organelle maintenance (mitochondrion/vacuole) and energy production, with growth-related terms likely reflecting broader cellular context rather than core function.","confidence":"Medium","size":12,"edges":62,"triangles":181,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":3},{"id":"GO:0006814","count":3},{"id":"GO:0042777","count":3},{"id":"GO:0007035","count":3},{"id":"GO:0006626","count":3}]},{"hash":"1331021822927506255","title":"Vascular Tone and Thermogenesis Regulators","description":"The GO terms point to vascular smooth muscle regulation (calcium import, smooth muscle contraction, vasoconstriction, blood pressure regulation) and metabolic/thermogenic processes (diet-induced thermogenesis, cellular response to temperature). Immune/stress-related responses (lipopolysaccharide, xenobiotic stimulus) are present but appear secondary, so the central theme is vasoactive control combined with thermogenesis.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0098703","count":4},{"id":"GO:0006828","count":4}]},{"hash":"2175245556432650105","title":"Neural development and synaptic signaling","description":"The cluster is dominated by terms tied to nervous system development (including hippocampus development and axon guidance) and synaptic regulation, such as regulation of synaptic vesicle exocytosis and dendritic spine development, with supporting signaling pathway terms (ERK cascade, PI3K activity) that modulate neuronal growth and synaptic function. While a signaling term from the immune context appears, the overall pattern strongly points to neuronal differentiation and synaptic wiring.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:2000300","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0043552","count":6}]},{"hash":"1845493073852760894","title":"Synaptic Trafficking and Adhesion Regulation","description":"The cluster centers on membrane trafficking and synaptic function (regulation of synaptic vesicle exocytosis, endosome-to-Golgi transport, dendrite development, and synapse plasticity) while also highlighting cell adhesion and cytoskeletal dynamics (epithelial adhesion, tight junctions, stress fiber/cell spreading). This suggests a module coordinating neuronal synaptic activity with adhesion and structural remodeling.","confidence":"Medium","size":12,"edges":5,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000300","count":5},{"id":"GO:0090136","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0034498","count":5}]},{"hash":"293208117465698677","title":"Reproductive Organ Development","description":"The dominant terms describe development of reproductive tissues (female genitalia, uterus, female gonad, prostate), implying a cohesive set of genes guiding gonadal development; a few immune-regulatory terms are also present, likely reflecting secondary roles or shared pathways.","confidence":"High","size":12,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030540","count":3},{"id":"GO:0002677","count":3},{"id":"GO:0060736","count":3},{"id":"GO:0035865","count":3},{"id":"GO:0090350","count":3}]},{"hash":"1188187006288638791","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by terms related to translation (including cytoplasmic translation and initiation/termination) and ribosome biogenesis (rRNA maturation for SSU/LSU), with additional RNA quality control (RNA surveillance, no-go decay). The presence of an antibiotic response term also aligns with components of the ribosome/translation machinery. This points to a cohesive group of proteins involved in ribosome assembly and protein synthesis.","confidence":"High","size":12,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0002181","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0070966","count":1}]},{"hash":"2045434743542263976","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":3},{"id":"GO:0006382","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0050689","count":2}]},{"hash":"599767288219341165","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000480","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1020613395569654197","title":"Proteostasis and stress signaling","description":"The cluster is dominated by oxidative stress and heat/light stress response terms (negative regulation of ROS, response to hydrogen peroxide, regulation of cellular response to heat, response to high light), along with proteostasis and quality-control processes (ubiquitin-dependent ERAD, protein stabilization, regulation of amyloid fibril formation) and stress-activated MAPK signaling, indicating a cohesive theme of stress response coupled with protein quality control.","confidence":"High","size":12,"edges":25,"triangles":28,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":3},{"id":"GO:0042542","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0051403","count":2},{"id":"GO:0099641","count":2}]},{"hash":"358437520849988507","title":"Intracellular organelle organization and cell cycle","description":"The top GO terms include cell cycle, cell division, mitochondrial membrane organization and distribution, ribosomal large subunit export, autophagy-related phagophore localization, and vesicle trafficking, suggesting a general theme of coordinated intracellular organization and transport during proliferation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007049","count":5},{"id":"GO:2000300","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0021799","count":4},{"id":"GO:0051301","count":4}]},{"hash":"1825258532646679432","title":"Proteostasis and Development","description":"The cluster mixes GO terms centered on the ubiquitin-proteasome system (ubiquitination, SCF-dependent proteasomal degradation, ERAD) with developmental processes (osteoblast differentiation, skin development, male gonad development) and transcriptional activity, suggesting proteins that connect protein turnover to developmental regulation and differentiation signals.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001649","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0030433","count":4}]},{"hash":"1866424247245962637","title":"Microbial Metabolism and Stress Response","description":"The GO terms cluster around diverse metabolic pathways (C1 metabolism: methanol/methane, thiazole biosynthesis, UMP salvage, glycine betaine biosynthesis) and environmental stress responses (cold, hydroperoxide), with some lipid metabolism involvement. This combination suggests a set of proteins involved in core metabolism plus adaptation to stress, typical of microbial systems, hence a label reflecting both metabolism and stress response.","confidence":"Medium","size":12,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0015945","count":4},{"id":"GO:0008203","count":4},{"id":"GO:0046188","count":4},{"id":"GO:0019285","count":4}]},{"hash":"1594283817060262727","title":"Diverse metabolite and cell-envelope biosynthesis","description":"These proteins appear linked to a broad set of biosynthetic processes, spanning bioplastics (poly-hydroxybutyrate), plant secondary metabolites (anthocyanin- and phenylpropanoid biosynthesis), wax production, and cell-surface components such as lipopolysaccharide O antigen and core biosynthesis, as well as antibiotic biosynthesis. The common theme is synthesis of a wide range of metabolites and structural components, rather than a single, focused pathway.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042619","count":6},{"id":"GO:0006212","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0009718","count":3}]},{"hash":"400788396730776594","title":"Cell-cycle Regulation and Stress Signaling","description":"The cluster shows a concentration of regulatory GO terms around the cell cycle and DNA damage checkpoints, plus translational control via eIF2\u03b1 dephosphorylation, and inflammatory/metabolic signaling (prostaglandin biosynthesis, response to toxic substances). While a few terms (e.g., dendrite morphogenesis, cocaine response) seem peripheral, the core theme points to coordinated regulation of cell division and stress responses.","confidence":"Medium","size":12,"edges":12,"triangles":4,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060316","count":5},{"id":"GO:0001516","count":4},{"id":"GO:0009636","count":3},{"id":"GO:0051726","count":3},{"id":"GO:2000002","count":3}]},{"hash":"1949620038308099910","title":"Cerebellar development and neural signaling","description":"The top GO terms cluster around cerebellar and brain development (cerebellar cortex formation, Bergmann glial differentiation, orbitofrontal cortex development via FGFR signaling) and neuronal signaling pathways (insulin receptor signaling, T cell receptor signaling, axon regeneration). Although there are a few cell-cycle terms (centriole replication, meiotic DNA double-strand break processing), the dominant theme is brain development and neural signaling.","confidence":"Medium","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0008285","count":12},{"id":"GO:0048679","count":12},{"id":"GO:0050852","count":12},{"id":"GO:2001275","count":12},{"id":"GO:0060020","count":12}]},{"hash":"218273662456474979","title":"Stem Cell Regulation and RNA Processing","description":"The cluster contains GO terms pointing to stem cell population maintenance and its regulation, coupled with transcription initiation, RNA splicing/spliceosome activity, and translational control, plus androgen receptor signaling and cell cycle. This suggests a cohesive module where stem cell fate is governed by coordinated transcriptional and post-transcriptional gene expression mechanisms, with AR pathway involvement.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902455","count":2},{"id":"GO:0006367","count":2},{"id":"GO:0030521","count":2},{"id":"GO:0019827","count":2},{"id":"GO:2000825","count":1}]},{"hash":"343618396281952178","title":"Viral entry and proviral integration","description":"The terms cluster around viral entry into host cells, reverse transcription-like DNA synthesis, DNA replication and integration, and proviral latency establishment. Several GO terms explicitly describe retroviral processes (RNA-templated DNA biosynthetic process, DNA integration, integrated proviral latency), with related signals of host\u2013virus interactions such as apoptosis activation and antiviral RNA processing. This coherence suggests a viral infection/proviral integration theme.","confidence":"High","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0075732","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0006310","count":5},{"id":"GO:1903704","count":5}]},{"hash":"1187987451827821762","title":"Innate immunity and keratinocyte differentiation","description":"This cluster is dominated by GO terms for innate immune response and defense against bacteria (Gram-positive and LPS stimulation), GM-CSF signaling, and T cell receptor signaling, pointing to immune activation. The presence of keratinocyte differentiation suggests skin-related immune functions, indicating a theme of immune signaling in epidermal cells. The additional terms related to transcription/export and apoptosis reflect broader cellular activation rather than a single pathway, but the core signal is immune-responsive activity with skin-associated differentiation.","confidence":"Medium","size":12,"edges":41,"triangles":65,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0046827","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0050852","count":5}]},{"hash":"7831240578538410","title":"T cell development and signaling","description":"The top GO terms point to thymus development, NK T cell differentiation, and IL-4 production, indicating a T cell\u2013related lineage. Additionally, multiple signaling-related terms (Wnt signaling, ERK/MAPK cascade, JNK activation, and tyrosine autophosphorylation) suggest T cell receptor\u2013mediated signaling and cytoskeletal dynamics (actin binding, transcytosis) that accompany T cell activation and development. The cluster thus centers on T cell development in the thymus and associated signaling pathways.","confidence":"High","size":12,"edges":20,"triangles":9,"max_degree":7,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0048538","count":8},{"id":"GO:0090263","count":8},{"id":"GO:0071226","count":7},{"id":"GO:0032633","count":7},{"id":"GO:0007257","count":7}]},{"hash":"466029321364713486","title":"Embryonic and Tissue Development","description":"The top GO terms cover diverse developmental processes across multiple tissues (nervous system, pancreas, heart, placenta, cartilage) and patterning, indicating a broad role in embryogenesis and morphogenesis rather than a single pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021762","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0007279","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2}]},{"hash":"864830141085582968","title":"Proviral integration and latency machinery","description":"The cluster centers on genes involved in DNA recombination and replication, DNA integration, RNA-templated DNA synthesis, and established proviral latency, along with processes like viral entry into the host nucleus and symbiont-driven effects on the host (including apoptosis). The presence of negative regulation of siRNA processing suggests viral or symbiont-mediated suppression of host RNAi, all pointing to a cohesive theme of genome integration and latency within host cells.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":8},{"id":"GO:0006260","count":8},{"id":"GO:0075732","count":7},{"id":"GO:0046718","count":7},{"id":"GO:1903704","count":7}]},{"hash":"1770113741834322525","title":"Membrane Metabolite Transport","description":"The cluster is dominated by GO terms for transport across the plasma membrane of diverse substrates (trehalose, urate, fructose, glucose, selenite, organic anions, and xenobiotics) and related metabolic responses, indicating a cohesive theme of membrane transport of metabolites and related compounds.","confidence":"High","size":12,"edges":16,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":11},{"id":"GO:0015747","count":11},{"id":"GO:0042149","count":11},{"id":"GO:1990539","count":11},{"id":"GO:0097080","count":11}]},{"hash":"1304911768741375024","title":"Diverse Biosynthetic Pathways","description":"The top GO terms cover a broad set of biosynthetic processes across different metabolite classes (antibiotics, fatty acids, pigments like melanin and anthocyanin, retinol, PHB, lipoteichoic acid, and sugar nucleotide derivatives), indicating the cluster centers on general biosynthetic activity rather than a single, cohesive pathway. This warrants a broad label that captures multiple biosynthetic roles.","confidence":"Medium","size":12,"edges":50,"triangles":105,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0042572","count":4},{"id":"GO:0006633","count":4},{"id":"GO:0009718","count":4}]},{"hash":"142129588052708094","title":"Neural development and synaptic regulation","description":"The cluster shows strong signals for neural-related processes: maintenance of synapse structure, positive regulation of synapse assembly, and motor learning, plus peripheral nervous system myelination. VEGF production and negative regulation of angiogenesis suggest neurovascular interplay, which can accompany neural development. Some terms (skin development, surfactant homeostasis) are peripheral and may reflect broader tissue annotation. Overall, the dominant theme is neural development and synaptic plasticity with related signaling. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":4},{"id":"GO:0010573","count":3},{"id":"GO:0061743","count":3},{"id":"GO:0099558","count":3},{"id":"GO:0051965","count":3}]},{"hash":"852450789341736835","title":"Flavonoid and lignin biosynthesis","description":"Based on the GO terms, the proteins cluster around biosynthesis of flavonoids and lignin, including anthocyanin-containing compounds, kaempferol and cyanidin glucosides, and lignin metabolism, which are all products of the phenylpropanoid pathway. The presence of related antibiotic metabolism terms may reflect incidental or broad metabolic annotation, but the dominant signal is flavonoid/lignin biosynthesis in plants.","confidence":"High","size":12,"edges":28,"triangles":28,"max_degree":11,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":11},{"id":"GO:0009718","count":8},{"id":"GO:0071412","count":7},{"id":"GO:0030259","count":7},{"id":"GO:0033330","count":7}]},{"hash":"1815323699609861108","title":"Diverse membrane transporters","description":"GO terms indicate transmembrane transport across a wide range of substrates (xenobiotics, phosphate, nitrate/nitrite, sodium, vitamin, fucose, and other metabolites) plus vesicular neurotransmitter loading. This collective signal points to a cluster of membrane transporter proteins with varied substrates, justifying the label \"Diverse membrane transporters.\"","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0035435","count":1},{"id":"GO:0098700","count":1},{"id":"GO:0015706","count":1},{"id":"GO:0015707","count":1}]},{"hash":"611414824313166709","title":"Diverse biosynthesis and catabolic processes","description":"Top GO terms indicate a mix of biosynthetic and catabolic activities across a range of compounds (antibiotics, melanin, tropane alkaloids, phylloquinone, steroids, acetoin), along with sporulation and development-related terms. This suggests proteins involved in broad secondary metabolism and metabolite remodeling rather than a single, cohesive pathway. ","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0045150","count":6},{"id":"GO:0042619","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0042438","count":6}]},{"hash":"2149138193653141725","title":"Unknown","description":"Top GO terms are highly diverse, including several biosynthetic/metabolic processes (antibiotic biosynthesis, poly-hydroxybutyrate biosynthesis, melanin biosynthesis, 3-keto-sphinganine metabolism) alongside developmental and regulatory terms (lung development, sporulation, regulation of transcription) and a drug-response term (response to methotrexate). The lack of a single cohesive function or pathway linking these terms makes it hard to assign a specific, representative label to this cluster.","confidence":"","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0017000","count":7},{"id":"GO:0042619","count":7},{"id":"GO:0045150","count":6},{"id":"GO:0042438","count":6}]},{"hash":"183731638132485759","title":"Epithelial Polarity and Tissue Morphogenesis","description":"The most represented GO terms center on establishing and maintaining epithelial apical/basal polarity, along with related developmental processes such as EMT and tissue morphogenesis (cartilage, pancreas development, endocardial cushion formation). A couple terms (DNA replication, triglyceride catabolism) are less directly related, but the recurring theme of epithelial organization and embryonic tissue development dominates the cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0045198","count":2},{"id":"GO:0045199","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0019433","count":2}]},{"hash":"1662967622433309467","title":"Antiproliferative signaling and transport regulators","description":"This cluster combines terms for apoptosis promotion, suppression of cell proliferation, Wnt signaling inhibition, and cell migration, alongside nuclear import and mRNA transport and mitotic regulation. The common theme appears to be regulators that coordinate cell fate, movement, and intracellular signaling/trafficking rather than a single, cohesive enzymatic function. ","confidence":"Medium","size":12,"edges":4,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":7},{"id":"GO:0006607","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0042144","count":5},{"id":"GO:0008285","count":5}]},{"hash":"881293884231845627","title":"Embryonic organogenesis and patterning","description":"The top GO terms cluster around embryonic development, including heart-related endocardial cushion formation, cartilage morphogenesis, left-right pattern formation, placenta and trophoblast differentiation, and endocrine/pancreatic organ development, suggesting roles in early development and tissue patterning across multiple organs. Some terms reflect general transcriptional regulation or RNA processing, which can support broad developmental programs but do not override the cohesive developmental theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":11},{"id":"GO:0060536","count":11},{"id":"GO:0060972","count":11},{"id":"GO:0060806","count":11},{"id":"GO:0060707","count":11}]},{"hash":"687511038785432165","title":"Ubiquitin-Dependent Proteolysis and Immune Regulation","description":"The top terms cluster around ubiquitin-mediated proteolysis (including K33-linked ubiquitination) and immune-regulatory processes (dendritic cell differentiation, type 2 immune response, mast cell cytokine regulation, IgE isotype switching), suggesting a coherent theme of ubiquitin-controlled immune signaling. Some terms (circadian rhythm, renal sodium absorption, muscle development) are less connected, indicating mixed functions within the set.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0048741","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0042748","count":3},{"id":"GO:1900477","count":3}]},{"hash":"578749489489257849","title":"Unknown","description":"The top GO terms include muscle-related processes (sarcomere organization, smooth muscle proliferation), immune functions (MHC II antigen presentation, B-1 B cell differentiation, dendritic cell differentiation, IL-2 production), and diverse developmental morphogenesis signals (nerve and retina development, salivary gland branching, FGFR signaling), suggesting no single coherent function ties all proteins together.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0002588","count":2},{"id":"GO:0060665","count":2},{"id":"GO:0001923","count":2},{"id":"GO:1900042","count":2}]},{"hash":"1010452950907950191","title":"Nucleotide salvage and phosphorylation metabolism","description":"The Top Terms include multiple salvage pathways (uracil salvage, CTP salvage, UMP salvage) and phosphorylation-related processes (phosphorylation, carbohydrate phosphorylation), indicating a metabolic focus on nucleotide salvage coupled with phosphorylation. Some terms (root meristem growth, negative regulation of MDA-5 signaling) are broader or cross-species annotations, but the core theme centers on salvage and phosphorylation metabolism. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":2},{"id":"GO:0010449","count":2},{"id":"GO:0097056","count":2},{"id":"GO:0006223","count":1},{"id":"GO:0044211","count":1}]},{"hash":"1556381939579000913","title":"GPCR-Linked Visual and Cardiac Signaling","description":"The cluster is dominated by GO terms related to GPCR signaling and visual processes (regulation of opsin-mediated signaling, visual perception, GPCR internalization, and regulation of GTPase activity), with additional terms pointing to cardiac development and contraction, suggesting a broader role for GPCR-mediated signaling in both visual and cardiovascular contexts. Some terms (immune responses and spindle organization) appear less related and may reflect annotation noise or multifunctionality. Overall, the core theme is GPCR-driven signaling in visual and cardiac tissues.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0022400","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0002031","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1670367385981441439","title":"Endocytosis and developmental signaling","description":"The cluster shows prominent endocytosis and actin organization terms, plus developmental and signaling processes (retinoic acid response, organ morphogenesis, synaptic plasticity, growth hormone secretion). This suggests proteins involved in endocytic trafficking that interfaces with neuronal development and tissue morphogenesis. ER stress\u2013related translation regulation and Ras signaling terms point to broader regulatory roles that often accompany endocytic and developmental pathways.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:1901076","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0048170","count":2}]},{"hash":"1066026649282295397","title":"Chondrogenesis, Osteogenesis, and Palate Development","description":"The top GO terms cluster around cartilage formation (chondrocyte differentiation, endochondral ossification) and bone formation (osteoblast differentiation), plus palate development (roof of mouth), with supporting roles in cell-matrix adhesion and tissue remodeling during skeletal development. This cohesive theme suggests a skeletal/cartilage formation program with craniofacial morphogenesis.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002062","count":3},{"id":"GO:0035025","count":3},{"id":"GO:0045669","count":3},{"id":"GO:0001958","count":3},{"id":"GO:0048661","count":2}]},{"hash":"169273204071869503","title":"Diverse plasma membrane solute transporters","description":"The GO terms indicate transport of a wide variety of solutes (trehalose, urate, fructose, sialic acid, phosphate, vitamins, xenobiotics, selenite, organic anions) across the plasma membrane, plus a cellular response to glucose starvation. This points to a group of membrane transport proteins with broad or varied substrate specificity, rather than a single-substrate transporter, justifying a label of diverse solute transporters.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0015747","count":4},{"id":"GO:0042149","count":4},{"id":"GO:1990539","count":4}]},{"hash":"2007341684994610656","title":"Translation initiation and mRNA processing regulation","description":"The top GO terms point to control of translation initiation (translation reinitiation, preinitiation complex formation, translational initiation regulation) and various aspects of mRNA life cycle (stability, splicing, poly(A) tail regulation) especially under stress, including IRES-dependent initiation. This suggests a cohesive function in coordinating how mRNA is translated and processed, rather than a single specialized process.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":6},{"id":"GO:0010610","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0048026","count":5},{"id":"GO:0075522","count":5}]},{"hash":"450145195000345717","title":"Ribosome biogenesis and translational initiation","description":"This cluster is dominated by GO terms tied to ribosome assembly and the initiation/ reinitiation steps of translation (ribosome biogenesis, formation of translation preinitiation complex, regulation of translational initiation, translation reinitiation, IRES-dependent viral initiation). These collectively point to a functional module involved in ribosome production and control of protein synthesis initiation. A couple of terms like chromatin organization and growth-hormone response are less central and may reflect broader roles of members.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0031497","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1644600399035242497","title":"Neuroimmune Stress Signaling and GPCR-cGMP Pathways","description":"The proteins cluster around inflammatory and xenobiotic responses (LPS, xenobiotics), modulation of inflammation, coagulation, and a GPCR signaling axis coupled to cGMP, with links to autonomic/behavioral processes (feeding regulation, heart rate, grooming, smooth muscle tone). This suggests an integrated neuroimmune-cardiovascular stress signaling theme.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0050728","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0043278","count":4}]},{"hash":"1205531661261602952","title":"Neural development and axon guidance signaling","description":"This cluster is enriched for nervous system development and axon guidance terms, including Roundabout signaling (Slit-Robo) and Hedgehog/SMO pathways, along with ERK cascade regulation, pointing to developmental signaling that shapes neural connectivity; kidney development appears as broader morphogenesis context, but neural guidance is the dominant theme.","confidence":"High","size":11,"edges":20,"triangles":7,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0007224","count":5}]},{"hash":"1263564393435876047","title":"Cell Cycle and Signaling Regulation","description":"The term set centers on DNA replication (cell cycle) and various signaling pathways (Wnt regulation, T cell receptor signaling) along with related processes like cell morphogenesis and mitotic regulation, suggesting a cohesive theme of coordinating cell growth/division with signaling. Additional terms on protein targeting, ubiquitin-related regulation, and stress responses reflect broader regulatory roles but still fit the overarching theme of regulation of proliferation and signaling.","confidence":"Medium","size":11,"edges":17,"triangles":8,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0000902","count":4},{"id":"GO:0090090","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0051436","count":3}]},{"hash":"1296448790016071985","title":"DNA replication and genome maintenance","description":"The proteins cluster around GO terms for DNA replication, repair, telomere maintenance, and chromosome segregation, suggesting a cohesive role in preserving genome integrity during replication and cell division.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030263","count":3},{"id":"GO:0007004","count":2},{"id":"GO:0097046","count":2},{"id":"GO:0006261","count":2},{"id":"GO:0006307","count":2}]},{"hash":"1740114926217704072","title":"Transcriptional Regulation and Proteostasis","description":"The GO terms are dominated by transcriptional control by RNA polymerase II (positive and negative regulation) and DNA binding regulation, suggesting a core function in nuclear gene regulation. Additionally, signals related to proteostasis\u2014protein dephosphorylation, protein repair, translation, and an ER stress response term\u2014point to quality control in protein synthesis and folding. The digestion and fatty acid biosynthesis terms are less cohesive with the main theme, possibly reflecting multifunctional proteins or broader metabolic links to membrane processes. Overall, the cluster appears to center on transcriptional regulation with connected proteostasis/ER stress responses.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0043388","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006470","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0007586","count":2}]},{"hash":"1189904113382892183","title":"Transmembrane Transport","description":"The cluster shows several transmembrane transport GO terms (potassium, nitrate/nitrite, phosphate, xenobiotic transport) and related processes like neurotransmitter loading into synaptic vesicles, indicating a coherent theme around membrane transport. A few outliers (DNA-templated transcription, bone mineralization) are present but less central to the dominant transport signature.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0030282","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0035435","count":2}]},{"hash":"2211330035707408712","title":"Mitotic Division and Proliferation","description":"This cluster is dominated by GO terms for mitosis and cell division (mitotic spindle assembly, mitotic cell cycle, cell division) and proliferation-related processes (cell population proliferation, multicellular organism growth). Additional terms point to signaling (ERK cascade regulation) and cytoskeletal/trafficking components, suggesting proteins that coordinate division with growth signals and cellular architecture.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0035264","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0000278","count":2}]},{"hash":"828966129403577913","title":"Angiogenesis, endothelial remodeling, and coagulation","description":"This cluster combines GO terms centered on vascular biology: angiogenesis and positive regulation of endothelial barrier establishment, plus tissue remodeling and coagulation-related processes (Factor XII activation and fibrinolysis). Immune-related terms (neutrophil-mediated killing) appear but are secondary; overall the theme points to vascular remodeling with coagulation involvement.","confidence":"Medium","size":11,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0042595","count":2},{"id":"GO:1903142","count":1},{"id":"GO:0070947","count":1},{"id":"GO:0002542","count":1}]},{"hash":"1801982067117018734","title":"Plasma Membrane Transporters for Xenobiotics and Nutrients","description":"These proteins show strong enrichment for transmembrane transport terms across the plasma membrane, covering xenobiotics, vitamins, sugars, ions, and organic anions. The common theme is membrane transport activity with diverse substrates, supporting a label of plasma membrane transporters with broad specificity.","confidence":"High","size":11,"edges":26,"triangles":24,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":11},{"id":"GO:0035461","count":11},{"id":"GO:0042908","count":11},{"id":"GO:0071805","count":11},{"id":"GO:0015771","count":10}]},{"hash":"2123585357289317460","title":"Cellular stress response and translational control","description":"The cluster shows enrichment for cellular responses to oxidative and nitrosative stress (hydrogen peroxide, nitric oxide) and to ethylene, plus terms related to translation initiation and its regulation, suggesting a coordinated stress signaling and control of protein synthesis. An outlier term on oligodendrocyte development is present but likely incidental. Together, these terms point to a theme of stress response coupled with translational regulation, hence the chosen label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":2},{"id":"GO:0071732","count":1},{"id":"GO:0019284","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0019509","count":1}]},{"hash":"910436637598031568","title":"Bacterial fatty acid transport and metabolism","description":"This cluster is dominated by GO terms related to long-chain and medium-chain fatty acid transport and metabolism (import into cell, metabolism), plus related lipid biosynthesis/processing terms (lipoteichoic acid biosynthesis, menaquinone biosynthesis) that are characteristic of bacterial lipid handling. Other terms point to broader bacterial carbon metabolism (malonate catabolism, pyruvate fermentation to acetate). The common thread is bacterial lipid uptake and processing, with one term likely representing noise. ","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":6},{"id":"GO:0009234","count":6},{"id":"GO:0015911","count":5},{"id":"GO:0090410","count":5},{"id":"GO:0010030","count":5}]},{"hash":"1359133937127847446","title":"Growth signaling and development","description":"The cluster shows enrichment for TORC1 signaling (growth control), positive regulation of kinase activity, and mitotic cell cycle progression, along with terms related to cytoskeletal organization (terminal web assembly, GTPase activity) and tissue development (skin and skeletal muscle). This suggests a shared theme of growth-related signaling coordinating cell proliferation, cytoskeletal dynamics, and differentiation across contexts. Confidence: Medium","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038202","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0043588","count":2},{"id":"GO:1902896","count":2},{"id":"GO:0098907","count":2}]},{"hash":"1998282161432503237","title":"Cell cycle regulation and nuclear transport","description":"The terms center on mitosis and cell-cycle control (sister chromatid separation, cell division, regulation of the cell cycle) and nuclear transport (NLS-bearing protein import into nucleus; mRNA transport), with supporting roles for GTPase activity, protein regulation, and phosphorylation-related processes. This suggests a cohesive cluster of proteins coordinating cell division with nuclear-cytoplasmic trafficking and regulatory signaling.","confidence":"High","size":11,"edges":16,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051306","count":4},{"id":"GO:0006607","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0007050","count":3}]},{"hash":"1713132851543782717","title":"Mammalian Development and Immune Signaling","description":"The proteins are enriched for GO terms tied to multicellular development and organogenesis (heart development, branching in mammary gland ducts, metanephric distal tubule development) as well as angiogenesis and immune pathways (complement activation, B cell receptor signaling). This mix suggests a cluster of factors involved in developmental processes with concurrent immune signaling components, rather than a single, cohesive pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0060444","count":4},{"id":"GO:2001137","count":4},{"id":"GO:0072221","count":4}]},{"hash":"1065767391038536797","title":"Coagulation and endothelial barrier regulation","description":"This cluster prominently features GO terms for blood coagulation, fibrinolysis, Factor XII activation, and positive regulation of coagulation, as well as establishment of the endothelial barrier, pointing to a module that coordinates clotting and vascular integrity. There is also a defense component against Gram-positive bacteria, suggesting a link between coagulation/vascular responses and innate immunity. Some terms are broader or peripheral (transcriptional regulation, glucose response), but the core signal centers on coagulation and vascular barrier functions in immune contexts.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0042730","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0071333","count":2}]},{"hash":"2223867916963299276","title":"Vacuolar amino acid transport","description":"This cluster is dominated by GO terms for transmembrane transport of various amino acids into or out of the vacuole (e.g., histidine, glutamate, tyrosine, lysine, arginine, asparagine, glutamine), indicating a coherent function in vacuolar amino acid transport. A single term about root cap development is present but does not override the strong pattern of amino-acid vacuolar transport, suggesting the proteins together mediate amino acid movement across the vacuolar membrane.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090513","count":2},{"id":"GO:0090452","count":2},{"id":"GO:0006867","count":2},{"id":"GO:0090515","count":2},{"id":"GO:2000487","count":2}]},{"hash":"1237525807448799306","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075522","count":2},{"id":"GO:0007507","count":2},{"id":"GO:1990928","count":1},{"id":"GO:0034414","count":1},{"id":"GO:0038202","count":1}]},{"hash":"797924033747681975","title":"Insect lipid metabolism and water barrier development","description":"This cluster is enriched for lipid-related processes (sphingosine biosynthesis; monounsaturated fatty acid biosynthesis) and adipogenesis (white fat cell differentiation), plus insect integument functions like tarsal gland development and water loss regulation. The combination points to lipid metabolism coupled with cuticular/water barrier or gland-associated roles in insects, supporting a coherent theme of lipid biosynthesis and integumentary barrier function. ","confidence":"High","size":11,"edges":23,"triangles":36,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0033561","count":6},{"id":"GO:0046512","count":6},{"id":"GO:1903699","count":6},{"id":"GO:1903966","count":6},{"id":"GO:0034435","count":6}]},{"hash":"2293294763098746854","title":"RNA processing and localization in development","description":"Most top GO terms point to RNA biology, including oskar mRNA localization and translation regulation, pole plasm regulation, snoRNP assembly, and rRNA processing/localization of telomerase RNA. While there are also development-related terms (neuron differentiation, neuromuscular junction assembly, meiosis, stem cell maintenance), the shared thread appears to be RNA biogenesis and localization with broader developmental control. This supports a label capturing RNA processing/localization within developmental contexts.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010446","count":1},{"id":"GO:0045665","count":1},{"id":"GO:0008582","count":1},{"id":"GO:0007319","count":1},{"id":"GO:0019827","count":1}]},{"hash":"569657413137537161","title":"Cardiac conduction and sarcomere organization","description":"This cluster is dominated by GO terms related to cardiac electrophysiology and muscle structure, including AV node action potential, regulation of heart rate by cardiac conduction, membrane depolarization, and sarcomere organization. While a few terms (smell perception, paraxial mesoderm development, T cell proliferation) are less obviously related, the overarching theme points to proteins involved in heart rhythm control and sarcomere integrity. ","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007608","count":3},{"id":"GO:0086016","count":2},{"id":"GO:0060371","count":2},{"id":"GO:0060168","count":2},{"id":"GO:0048339","count":2}]},{"hash":"1544269705330228580","title":"Inflammation and vascular signaling","description":"The top GO terms point to inflammatory and vascular responses, including response to lipopolysaccharide, tumor necrosis factor, blood coagulation, vasodilation, and regulation of nitric-oxide synthase activity, along with a pain response. This suggests a theme of inflammation-driven vascular signaling and pain. A few terms (dopamine biosynthetic process, one-carbon metabolic process, neuromuscular process) are less directly tied and may reflect broader cellular contexts or annotation noise.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0007596","count":2},{"id":"GO:2000121","count":1},{"id":"GO:0042311","count":1},{"id":"GO:0051000","count":1}]},{"hash":"1314368079125132225","title":"Fucose glycosylation and immune cell trafficking","description":"Main signal is fucose-containing glycosylation (L-fucose catabolic process; Lewis a epitope biosynthesis; N-glycan fucosylation) paired with immune functions (leukocyte migration; regulatory T cell differentiation). Some neural-development terms may reflect general migration processes but are less central. Thus the cluster likely represents glycosylation-dependent immune cell trafficking.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042355","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0036071","count":2},{"id":"GO:0097150","count":2},{"id":"GO:0010493","count":2}]},{"hash":"1060039176975581994","title":"Synaptic plasticity and AMPA receptor clustering","description":"These proteins cluster around neuronal synapses and regulate glutamatergic signaling and plasticity: GO terms point to positive regulation of glutamatergic synaptic transmission, positive regulation of synapse structural plasticity, and regulation of AMPA receptor clustering, with GKAP scaffolding involvement. A few terms reference immune signaling or social behavior, which are less directly connected, but overall the dominant theme is synaptic modulation and receptor organization.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031666","count":3},{"id":"GO:0048170","count":2},{"id":"GO:0097117","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0048671","count":2}]},{"hash":"2213644023111924026","title":"Neuronal synapse assembly and neuro-immune regulation","description":"The cluster features GO terms centered on synaptic assembly at the neuromuscular junction and glial differentiation, complemented by immune-regulatory terms (negative regulation of IL-2 production, T cell receptor signaling, and positive regulation of NLRP3 inflammasome assembly). Additional terms related to ER membrane fusion, protein localization, homologous oligomerization, and microtubule dynamics fit into the broader context of synapse formation and cytoskeletal remodeling that underpins neural-immune interactions. The set points to a cohesive theme around nervous system synapse assembly with accompanying immune modulation, though the immune terms introduce some breadth beyond pure synaptic biology. ","confidence":"Medium","size":11,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016320","count":2},{"id":"GO:1903077","count":2},{"id":"GO:1900025","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0051124","count":2}]},{"hash":"696800906646734353","title":"RNA Polymerase III Transcription","description":"Most of the top GO terms point to transcription mediated by RNA polymerase III, including DNA-templated transcription, transcription initiation by RNAP III, and preinitiation complex assembly. A couple of outliers (skeletal muscle differentiation and protein carbamoylation) are minor and do not define the cluster, so the dominant signal is RNAP III transcription-related components/functions.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0042791","count":2},{"id":"GO:0001041","count":2},{"id":"GO:0001009","count":2},{"id":"GO:0000999","count":2}]},{"hash":"1422264608703209924","title":"Vision and sensory neural signaling","description":"The top GO terms point to sensory perception (visual and auditory), light detection, and a receptor guanylyl cyclase signaling pathway, all tied to neural signaling and plasticity (long-term synaptic depression). While there are related terms in transcription and development, the dominant theme is neural/sensory processing, especially vision and sensory signaling, with some ancillary proteolysis. This suggests a cluster centered on sensory perception and neural modulation rather than a single enzymatic or developmental pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0050908","count":3},{"id":"GO:0007168","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0006508","count":3}]},{"hash":"2217789216075865181","title":"Mitochondrial regulation and phospholipid metabolism","description":"The set highlights several mitochondrial-focused processes (negative regulation of mitochondrial membrane potential, negative regulation of cytochrome c release, and regulation of cellular respiration) alongside lipid metabolism and transport (phospholipid translocation, phosphatidylcholine biosynthesis regulation, and choline transport). This pattern suggests a cohesive cluster centered on mitochondrial function linked to membrane lipid dynamics and associated regulation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010917","count":1},{"id":"GO:0045332","count":1},{"id":"GO:1901857","count":1},{"id":"GO:0090201","count":1},{"id":"GO:2001246","count":1}]},{"hash":"1353782340346383967","title":"Coagulation, fibrinolysis, and innate immunity","description":"This cluster centers on coagulation and fibrinolysis (Factor XII activation, plasminogen activation, fibrinolysis) together with endothelial barrier regulation and complement activation, plus neutrophil-mediated antimicrobial activity and tissue remodeling. The GO terms collectively point to an integrated coagulation and innate immune response at tissue interfaces, rather than a single pathway, supporting a coagulation-immune remodeling program. ","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:1903142","count":2},{"id":"GO:0070947","count":2},{"id":"GO:0002542","count":2},{"id":"GO:0048771","count":2}]},{"hash":"1119745765649417447","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":36,"triangles":67,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0071031","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0000398","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0000463","count":6}]},{"hash":"1625884172685733526","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":42,"triangles":98,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":8},{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0000463","count":6},{"id":"GO:0071042","count":6}]},{"hash":"1151586874162851224","title":"Nuclear DNA Replication and RNA Processing","description":"The cluster shows strong representation of nuclear processes: cell division, DNA replication and recombination, and RNA processing (alternative splicing and mRNA decay). A few viral/symbiont interaction terms may reflect annotation noise, but the core theme is nuclear nucleic acid metabolism and processing.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006727","count":2},{"id":"GO:0000380","count":2},{"id":"GO:0070478","count":1},{"id":"GO:0090502","count":1}]},{"hash":"476581029881297740","title":"RNA processing and splicing machinery","description":"This cluster is dominated by RNA metabolism terms: spliceosome assembly and mRNA splicing point to core RNA processing, supported by rRNA and tRNA maturation and P-body assembly, plus transcription termination. The ABA and water deprivation responses, and pericentric heterochromatin formation, may reflect regulatory or contextual roles rather than a primary function. Overall, the proteins cluster around RNA processing and splicing functions.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000245","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0006369","count":4},{"id":"GO:0042633","count":4},{"id":"GO:0009414","count":4}]},{"hash":"979749296984869004","title":"Viral infection cycle and host interactions","description":"This cluster centers on processes in the viral life cycle (entry, virion assembly, uncoating, proviral latency) and interactions with the host that enable infection and replication (host-driven activation of viral genomes, leukocyte involvement). The combination of these terms suggests a cohesive theme around virus-host interaction and the sequential steps of viral replication. ","confidence":"High","size":10,"edges":41,"triangles":92,"max_degree":9,"top_function":"protein folding","top_go_terms":[{"id":"GO:1901407","count":4},{"id":"GO:2000276","count":3},{"id":"GO:0000413","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0030260","count":3}]},{"hash":"1782200946912491294","title":"Amino acid and fatty acid metabolism","description":"The cluster shows multiple GO terms centered on biosynthesis and catabolism of amino acids (alanine, histidine, lysine via L-saccharopine) and central carbon metabolism (pyruvate), as well as fatty acid biosynthesis/elongation and related pathways, plus some antibiotic biosynthesis. Notch signaling appears but is not the dominant theme, making a metabolism-focused label appropriate.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042866","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0051792","count":2}]},{"hash":"1183287683238501459","title":"Oocyte Meiosis and Chromosome Segregation","description":"The GO terms are dominated by meiotic and oocyte-specific processes: regulation of meiotic cell cycle in oocytes, meiotic spindle elongation, sister chromatid separation, centromeric cohesion, and female meiotic nuclear division, collectively pointing to meiosis and chromosome segregation in oocytes. A few terms related to signaling and GTPase regulation appear, but the central theme remains meiosis-associated chromosome dynamics.","confidence":"High","size":10,"edges":18,"triangles":15,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1903538","count":2},{"id":"GO:0051232","count":2},{"id":"GO:0051306","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0070262","count":2}]},{"hash":"912391107763514805","title":"Mitochondrial redox metabolism and stress response","description":"Based on the GO terms, the cluster centers on redox-related processes and mitochondrial electron transport, with multiple chemical-stress response terms (aluminum ion, ethanol, herbicide) and a secondary signal for translation and biosynthesis. This suggests a coherent theme of mitochondrial energy/metabolism with redox balance and chemical stress response, justifying the label.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010044","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0006412","count":2}]},{"hash":"530665720105225861","title":"Retroviral infection and proviral latency","description":"The terms center on retroviral life cycle steps: viral entry into the host nucleus, reverse transcription (RNA-templated DNA synthesis), DNA replication and recombination, DNA integration, and establishment of integrated proviral latency, with additional notes on host responses and RNAi-related regulation. This combination strongly points to retrovirus-mediated genome integration and latency as the core theme.","confidence":"High","size":10,"edges":13,"triangles":4,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006310","count":6},{"id":"GO:0075732","count":5},{"id":"GO:0046718","count":5},{"id":"GO:1903704","count":5}]},{"hash":"1087635425751194901","title":"Vesicle trafficking and exocytosis","description":"The GO terms cluster around secretory vesicle handling and membrane trafficking\u2014from synaptic vesicle exocytosis and vesicle fusion with the Golgi to ER-to-Golgi transport and receptor recycling, as well as immune cell degranulation and histamine release. This suggests a cohesive role in the secretory pathway and exocytosis rather than a single signaling event.","confidence":"High","size":10,"edges":15,"triangles":8,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0016079","count":3},{"id":"GO:0042144","count":3},{"id":"GO:0043312","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0098967","count":3}]},{"hash":"813716647727646193","title":"Vertebrate neurodevelopment and organ morphogenesis","description":"The top GO terms are dominated by developmental processes across several vertebrate organs, especially brain development (brain development, forebrain proliferation, peripheral nervous system neuron development) and endocrine/reproductive organ formation (pituitary gland development, male gonad development). Additional terms cover craniofacial and lung morphogenesis (roof of mouth development, epithelial tube branching involved in lung morphogenesis) and general multicellular organism development, suggesting a cluster of proteins involved in morphogenesis and neural development. The single negative regulation of transcription by RNA polymerase II hints at regulatory roles in developmental gene expression, consistent with these processes.","confidence":"High","size":10,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0021846","count":5},{"id":"GO:0060021","count":5},{"id":"GO:0060441","count":5},{"id":"GO:0021983","count":5}]},{"hash":"2144191299517280875","title":"Mitochondrial Fusion and Translation Module","description":"The cluster shows strong signals for mitochondrial processes: mitochondrial fusion, membrane organization, and inheritance, plus translation-related terms (translation and tRNA modification). This points to a functional core related to mitochondrial genome expression and dynamics, i.e., coordinating protein synthesis within mitochondria with fusion/inheritance of the organelle. Some secondary terms (clathrin-dependent endocytosis, ion transport) may reflect broader membrane trafficking roles but do not outweigh the mitochondrial theme.","confidence":"High","size":10,"edges":25,"triangles":30,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0006400","count":3},{"id":"GO:0099132","count":2},{"id":"GO:0072583","count":2}]},{"hash":"1673724579579281971","title":"Diverse secondary metabolite biosynthesis","description":"This cluster shows a convergence on biosynthetic processes for specialized metabolites: melanin biosynthesis, antibiotic biosynthesis, tropane alkaloid biosynthesis, acetoin catabolic and 3-keto-sphinganine metabolic processes, and polyhydroxybutyrate biosynthesis, suggesting broad metabolic capabilities rather than a single pathway. A few terms (e.g., regulation of transcription, lung development) appear more peripheral, likely representing annotation breadth. Overall, the dominant signal is diverse metabolite production, supporting this label.","confidence":"High","size":10,"edges":36,"triangles":72,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0045150","count":8},{"id":"GO:0042619","count":8},{"id":"GO:0055114","count":8},{"id":"GO:0042438","count":8},{"id":"GO:0006355","count":8}]},{"hash":"684076527613958614","title":"Developmental differentiation across tissues","description":"The top GO terms point to development and differentiation across multiple tissues and lineages (neural regions like midbrain and hypothalamus, gonadal mesoderm, hepatoblasts, and odontogenesis), with no single unified function, so a broad multi-tissue developmental theme fits well.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0021763","count":4},{"id":"GO:0042663","count":4},{"id":"GO:0042475","count":4}]},{"hash":"332971933521522473","title":"Organogenesis via transcriptional regulation","description":"The cluster centers on transcriptional control (DNA-templated transcription, RNA polymerase II regulation, chromatin remodeling) and includes diverse organogenesis terms (lacrimal gland, retina, otic placode, nephron tubule formation, skeletal muscle differentiation), suggesting proteins that regulate transcription during organ development.","confidence":"High","size":10,"edges":24,"triangles":20,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0032808","count":3},{"id":"GO:0090190","count":3},{"id":"GO:0072289","count":3}]},{"hash":"1148608108574491761","title":"Unknown","description":"The top GO terms cover diverse processes (centriole replication, multiple growth factor signaling pathways, JNK cascade modulation, lipid biosynthesis, and hormonal responses) with no single shared function linking the proteins. The lack of a cohesive theme and no interactions (Edges 0) suggest no obvious common role, so the label Unknown is most appropriate.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007099","count":10},{"id":"GO:0035607","count":10},{"id":"GO:0000706","count":10},{"id":"GO:0071226","count":10},{"id":"GO:0046330","count":10}]},{"hash":"2002090212327210117","title":"Mitotic cell cycle regulation","description":"The top GO terms cluster around mitosis and cell-cycle control (protein localization to kinetochore; mitotic cell cycle; negative regulation of cyclin-dependent kinase activity; negative regulation of cell population proliferation). While other terms touch on signaling and neurodevelopment, the strongest common theme is regulation of mitosis and cell division, suggesting this cluster mainly reflects cell-cycle control mechanisms. ","confidence":"Medium","size":10,"edges":9,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":6},{"id":"GO:0008285","count":6},{"id":"GO:0048679","count":6},{"id":"GO:0050852","count":6},{"id":"GO:2001275","count":6}]},{"hash":"1176178947459025791","title":"Developmental transcriptional regulation","description":"This cluster's top GO terms are mainly about transcriptional regulation by RNA polymerase II and DNA-templated transcription, with several terms pointing to regulation of preinitiation complex assembly. A number of development-related terms across different tissues (harderian gland, trachea cartilage development, chondrocyte differentiation, male gonad development, spermatid nucleus differentiation, endocardial cell differentiation, and lung development) suggest a broader theme of transcriptional control during development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":2},{"id":"GO:0070384","count":2},{"id":"GO:0060534","count":2},{"id":"GO:0017055","count":2}]},{"hash":"1585365205957555936","title":"Cytoskeletal Remodeling and Mitosis","description":"The top GO terms cluster around actin filament depolymerization and sarcomere organization, plus mitotic cell cycle and spindle assembly, indicating a focus on cytoskeletal dynamics involved in cell division. While signaling terms (TGF-beta and cytokine production) appear, the strongest, most coherent theme is cytoskeletal remodeling coupled with mitosis.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0006351","count":2}]},{"hash":"759000458945872731","title":"Mitotic Cell Cycle Regulation","description":"Most terms point to mitosis and cell-cycle control (kinetochore localization, G2/M transition, and CDK activity regulation), indicating this cluster centers on mitotic regulation; the other terms (organ regeneration, visual perception, and synaptic potential) appear incidental and do not override the dominant mitotic theme.","confidence":"Medium","size":10,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":4},{"id":"GO:0045736","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0031100","count":3},{"id":"GO:0007601","count":3}]},{"hash":"32613625271123124","title":"Neural Development and Synaptic Plasticity","description":"This cluster shows strong neural-related terms: neuron differentiation, Schwann cell development, axonogenesis, and long-term synaptic potentiation, plus response to cocaine, pointing to neural development and synaptic signaling/plasticity. The DNA replication and cell cycle terms may reflect proliferative neural/glial progenitors or general cell cycle activity observed in neural contexts, and regulation of protein kinase activity aligns with signaling modulation in neurons. Overall, the core theme is neural development and synaptic function.","confidence":"Medium","size":10,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051321","count":5},{"id":"GO:0030182","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0000082","count":4}]},{"hash":"1581790335700490620","title":"Unknown","description":"The top GO terms are spread across DNA metabolism (DNA recombination, DNA integration, DNA replication) and various mammalian developmental processes (mammary gland development, lactation, cerebellar development, acrosome regulation, mammary involution) as well as other cellular processes (proteoglycan metabolism, glycosylation). There is no clear, single functional theme tying these proteins together, suggesting a mixed or non-cohesive cluster rather than a specific biological module.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006029","count":2},{"id":"GO:0030879","count":2}]},{"hash":"1746303182295202878","title":"Innate immunity and neutrophil antimicrobial defense","description":"The top GO terms cluster around innate immune response and neutrophil-mediated antimicrobial activities (fungal and Gram-positive bacterial killing), along with related inflammatory processes (humoral antibacterial response and tissue remodeling). A few terms (transcription regulation, endothelial barrier) are broader, but the dominant theme is innate immune defense and neutrophil effector functions.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035071","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0006962","count":1},{"id":"GO:1903142","count":1},{"id":"GO:0070947","count":1}]},{"hash":"1744761322801496485","title":"DNA Replication and Repair Regulation","description":"The top GO terms cluster around DNA replication, DNA damage checkpoint regulation, meiotic double-strand break formation, and repair via nonhomologous end joining, suggesting a core theme of genome maintenance and DNA damage response. A few terms refer to stress signaling or other processes (cocaine response, dendrite morphogenesis, cardiac hypertrophy), which may reflect annotation noise or multifunctional roles, but the dominant signal points to DNA replication/repair regulation. No edges are present to indicate direct interactions, so the label reflects shared function annotations rather than connectivity.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:2000002","count":2},{"id":"GO:0050774","count":2},{"id":"GO:0010780","count":2},{"id":"GO:0042220","count":2}]},{"hash":"82942642571129899","title":"Developmental signaling and proliferation cluster","description":"The terms point to roles in multicellular development and skin development, with positive regulation of cell proliferation and signaling via protein kinases and GTPases. The inclusion of mRNA transport and translation reinitiation suggests coordinated control of gene expression during development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051028","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0071902","count":2},{"id":"GO:0000278","count":2}]},{"hash":"541578061466121093","title":"Unknown","description":"The top GO terms cover ubiquitin-dependent proteolysis, circadian rhythm, various immune regulatory processes, muscle development, and renal function, with no single cohesive function tying all terms together. Therefore, there is no clear thematic cluster to label beyond Unknown.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0048741","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0042748","count":2},{"id":"GO:1900477","count":2}]},{"hash":"1778744767830167664","title":"Cell cycle control and telomere maintenance","description":"The cluster is dominated by terms tied to cell division control (centrosome cycle, CDK activity regulation) and telomere maintenance/capping, suggesting a core theme of cell proliferation and genome integrity. Other terms such as cell migration, mRNA processing, and differentiation (fat cells) appear peripheral or broader, but the primary signal centers on cell-cycle regulation and telomere maintenance.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":7},{"id":"GO:2001275","count":6},{"id":"GO:0032212","count":6},{"id":"GO:1904355","count":6},{"id":"GO:0035994","count":6}]},{"hash":"1864201957665261668","title":"mRNA Splicing and Translation Regulation","description":"The top GO terms cluster around mRNA processing (splicing, polyadenylation, splice site recognition, poly(A) tail regulation), mRNA stability, and various modes of translational control (initiation, reinitiation, and IRES-dependent translation), plus regulatory ncRNA-mediated silencing. This points to a cohesive theme of post-transcriptional gene expression regulation.","confidence":"High","size":9,"edges":16,"triangles":8,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0075522","count":4},{"id":"GO:0006376","count":4}]},{"hash":"450355016809929036","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":26,"triangles":33,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0048026","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0071042","count":1},{"id":"GO:0071894","count":1}]},{"hash":"307276690897386597","title":"Neuronal ion transport and synaptic plasticity","description":"The top GO terms cluster around transmembrane transport of ions (sodium, potassium, chloride, bicarbonate, sulfate, and L-aspartate), plus regulation of membrane potential and a term for long-term synaptic potentiation. This suggests a group of ion channels/transporters that modulate neuronal signaling and plasticity, with the auditory/sensory term indicating a neural context. The combination of ion transport and synaptic potentiation points to neural-ready transporter/protein sets.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:1900273","count":2}]},{"hash":"1345476238322547644","title":"Membrane transporters and adhesion in tissue remodeling","description":"Most frequent GO terms point to cell adhesion (cell adhesion, positive regulation of cell-matrix adhesion) and tissue remodeling (tissue regeneration, hyaloid vascular plexus regression), suggesting involvement in extracellular interactions during remodeling. The presence of multiple transmembrane transport terms (sodium/potassium ion transport, xenobiotic transport, trehalose transport, urate transport) and a cellular response to glucose starvation indicates these proteins are membrane-bound transporters with roles in metabolic stress and substrate movement. Together, these clues support labeling the cluster as membrane transporters linked to tissue remodeling.","confidence":"Medium","size":9,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1990384","count":2},{"id":"GO:0042246","count":2},{"id":"GO:0001954","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0035725","count":2}]},{"hash":"843479874236580466","title":"Steroid Hormone Signaling and Male Development","description":"Based on the prominent GO terms, the cluster is enriched for endocrine signaling and male reproductive development, including steroid hormone receptor complex assembly, prostate gland development, and male sex differentiation. Other terms present (interferon response, prolyl hydroxylation, phosphate transport) appear to be less central or incidental, so the main theme is steroid hormone signaling driving male development.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":2},{"id":"GO:0006463","count":1},{"id":"GO:0055114","count":1},{"id":"GO:1901874","count":1},{"id":"GO:0032364","count":1}]},{"hash":"2123988700344470978","title":"Broad substrate transmembrane transport","description":"These proteins appear to mediate transport across the plasma membrane for a wide range of substrates, including xenobiotics, vitamins, sugars, organic anions, urate, sialic acid, trehalose, and selenite. The diverse transport-related GO terms suggest a cluster of membrane transporters with broad or overlapping substrate specificities rather than a single-substrate transporter.","confidence":"Medium","size":9,"edges":19,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":8},{"id":"GO:0035461","count":8},{"id":"GO:0042891","count":8},{"id":"GO:0015771","count":6},{"id":"GO:0015747","count":6}]},{"hash":"1701610593906834069","title":"Virus entry and innate immune signaling","description":"The presence of GO terms related to virion attachment to host cells, cell surface protein localization, and actin cytoskeleton remodeling (actin rod assembly) points to processes involved in viral entry and host cell interaction. Concurrently, terms tied to interferon-mediated signaling and regulation of complement-dependent cytotoxicity suggest modulation of innate immune responses, while chaperone-mediated assembly and protein binding regulation hint at protein\u2013protein interactions essential for both entry and immune signaling. The mix implies a cluster centered on host\u2013virus interface and immune defense, with some annotations that may reflect broader cellular processes or noise (e.g., cuticle development).","confidence":"Medium","size":9,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0032092","count":1},{"id":"GO:2000010","count":1},{"id":"GO:0071318","count":1},{"id":"GO:0031247","count":1}]},{"hash":"1154684420632488713","title":"Microbial Metabolism and Protein Synthesis","description":"The cluster features GO terms tied to energy and nitrogen metabolism (nitrogen fixation; nitrate assimilation; formate metabolic process; ATP synthesis coupled electron transport) along with translation-related terms (translation; translational elongation). This suggests proteins involved in core cellular metabolism and protein synthesis in microbes. A few terms related to vasculature signaling (negative regulation of vasculogenesis, VEGF signaling) may reflect annotation noise or cross-species data, not a unifying functional theme. Overall, the dominant theme is metabolism paired with translation.","confidence":"Medium","size":9,"edges":19,"triangles":23,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009399","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0006414","count":1},{"id":"GO:2001213","count":1},{"id":"GO:0015942","count":1}]},{"hash":"2260772871638540139","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006784","count":1},{"id":"GO:0000961","count":1},{"id":"GO:0009451","count":1},{"id":"GO:0090617","count":1}]},{"hash":"2147969128274464360","title":"Mitochondrial lipid biosynthesis and energy metabolism","description":"The top GO terms cluster around lipid biosynthesis and remodeling (phosphatidylcholine, cardiolipin, ether lipids, triglycerides) together with mitochondrial ATP synthesis, pointing to a functional theme where lipid production/remodeling supports mitochondrial membranes and energy generation. Some terms reference development in specific tissues, but the dominant signal ties lipid metabolism to mitochondrial function. ","confidence":"High","size":9,"edges":12,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0016024","count":4},{"id":"GO:0002071","count":4},{"id":"GO:0036151","count":4},{"id":"GO:0035965","count":4},{"id":"GO:0019432","count":4}]},{"hash":"1098360443084203622","title":"Translation and transcription regulation during DNA damage response","description":"The top GO terms cluster around core translation processes (general translation, translational termination, ribosomal large subunit assembly, mitochondrial translation) and transcription control/regulation (transcription termination, elongation regulation, antitermination), plus a p53-mediated DNA damage response. This suggests a cohesive theme where protein synthesis and gene expression regulation are coordinated in response to DNA damage, including UV-induced regulation of translation.","confidence":"High","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006415","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0006353","count":2}]},{"hash":"1380900082732160289","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007338","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0043981","count":2}]},{"hash":"189512335039652440","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are dominated by translation and ribosome-related processes (translation, ribosome biogenesis, large/small subunit biogenesis, and ribosomal subunit export), indicating this cluster is centered on ribosome production and protein synthesis. A couple of non-ribosomal terms appear at low counts, but do not override the main theme.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1208896905910449449","title":"Ubiquitin-Mediated B Cell and Germinal Center Regulation","description":"This cluster is dominated by ubiquitin-related processes (ubiquitin-dependent proteolysis, K48/K63-linked ubiquitination, autoubiquitination) and immune signaling tied to B cell function and germinal center dynamics (Tfh differentiation, B cell homeostasis, TNF signaling). The common thread appears to be ubiquitin-mediated regulation of B cell\u2013germinal center responses.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0070534","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0061470","count":3},{"id":"GO:0030433","count":3}]},{"hash":"2151884199340344332","title":"Endocrine Organ Development","description":"The Top Terms center on development and differentiation of endocrine-related tissues (pituitary gland, pancreatic cells, endocrine system development) and embryonic patterning (left/right axis) along with morphogenesis (cartilage) and EMT-related processes. This points to a cohesive theme of organogenesis and endocrine tissue differentiation, with a couple of outliers (tRNA modification, aluminum response) that may be incidental. Overall, the cluster appears to encode proteins involved in developmental pathways shaping endocrine organs and body plan.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":4},{"id":"GO:0002098","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3}]},{"hash":"620888936515707239","title":"Mitochondrial translation machinery","description":"These proteins cluster around translation and tRNA aminoacylation, with multiple GO terms pointing to mitochondrial tRNA charging (glycyl-, glutamyl-, methionyl-, threonyl-, etc.) and general translation/ribosome assembly. While there are a couple unrelated terms, the dominant signal is mitochondrial protein synthesis, supporting this as the representative function of the cluster.","confidence":"High","size":9,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000027","count":1},{"id":"GO:0006424","count":1},{"id":"GO:0070584","count":1},{"id":"GO:0006431","count":1}]},{"hash":"851427063966352523","title":"Developmental gene regulation and growth","description":"The cluster\u2019s top terms point to developmental processes (multicellular growth, forebrain development) and regulation of gene expression (DNA-templated transcription, chromatin organization, mRNA transport), plus cell cycle signaling. This suggests a nuclear regulatory program coordinating development and proliferation, with a few mitochondrial terms likely incidental. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0006351","count":2}]},{"hash":"224057114337426121","title":"Unknown","description":"The listed GO terms cover a wide and disparate set of processes\u2014chromatin organization, lipid and cardiolipin metabolism, mitochondrial dynamics, collagen catabolism, P granule organization, and even obsolete terms\u2014without a clear, shared functional theme or interaction. The lack of edges and the presence of unrelated processes suggest no cohesive cluster function to name beyond Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034724","count":1},{"id":"GO:0035551","count":1},{"id":"GO:0034396","count":1},{"id":"GO:0030574","count":1},{"id":"GO:0006654","count":1}]},{"hash":"1093808594555853751","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0071031","count":1},{"id":"GO:0030260","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0010587","count":1}]},{"hash":"2303451079229138003","title":"Neuronal Golgi trafficking and proteostasis","description":"The top GO terms cluster around Golgi apparatus regulation and transport (regulation of Golgi organization, Golgi to lysosome transport, protein retention in Golgi) combined with neuronal terms (neuron development, visual perception, excitatory postsynaptic potential) and protein quality control processes (aggrephagy, regulation of proteasomal ubiquitin-dependent degradation). This suggests a module integrating Golgi-mediated trafficking with neuronal proteostasis and synaptic function. ","confidence":"High","size":9,"edges":9,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903358","count":3},{"id":"GO:0032435","count":3},{"id":"GO:0090160","count":3},{"id":"GO:0045053","count":3},{"id":"GO:0048666","count":3}]},{"hash":"866816669162187030","title":"Multi-substrate plasma membrane transport","description":"This cluster is characterized by GO terms pointing to transport across the plasma membrane for diverse substrates (xenobiotics, vitamins, trehalose, urate, fructose, selenite, organic anions, potassium), suggesting broad-spectrum transporter functions rather than a single substrate class.","confidence":"High","size":9,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":9},{"id":"GO:0035461","count":9},{"id":"GO:0042908","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0015771","count":8}]},{"hash":"39978404633165098","title":"Neural signaling and synaptic plasticity","description":"This cluster is dominated by GO terms tied to neuronal communication and synaptic changes, such as calcium-dependent exocytosis, excitatory postsynaptic potential, long-term potentiation, and visual perception. A few terms relate to cell cycle and centrosome processes, which may reflect shared multifunctional proteins rather than a cohesive non-neural theme; overall, the neural signaling/plasticity theme is the strongest signal.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0000086","count":2}]},{"hash":"16034004864319078","title":"Neural development and synaptic signaling","description":"This cluster centers on neural development and synaptic communication, with top terms focusing on axonogenesis, long-term synaptic potentiation, and excitatory postsynaptic potential. Additional terms reference Schwann cell development and visual perception, indicating broader nervous system maturation, though some terms touch on muscle and heart development. Overall, the strongest theme is neural development and synaptic function.","confidence":"Medium","size":9,"edges":24,"triangles":30,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010800","count":4},{"id":"GO:0007520","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0060291","count":4}]},{"hash":"1611005483441812347","title":"Synaptic signaling and plasticity regulation","description":"This cluster is dominated by neuronal-focused terms: regulation of long-term potentiation, synaptic vesicle exocytosis, dendrite morphogenesis, and mRNA transport, with additional notes on phosphorylation and protein kinase activity that modulate synaptic signaling. A few terms (mitotic cycle, obsolete apoptotic term) are less relevant, but the prevailing theme points to neuronal signaling and plasticity regulation. ","confidence":"Medium","size":9,"edges":14,"triangles":7,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":7},{"id":"GO:0086004","count":6},{"id":"GO:1900271","count":6},{"id":"GO:0051028","count":6},{"id":"GO:0050774","count":6}]},{"hash":"2254856697946394544","title":"Developmental signaling in muscle and nervous system","description":"The top terms cluster around development across multiple tissues (heart, muscle, Schwann cells, neurons) and associated signaling processes (phosphorylation, cAMP, transcription regulation), suggesting a general developmental signaling theme rather than a single pathway.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0010800","count":5},{"id":"GO:0007520","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0014044","count":5}]},{"hash":"1313215680368716769","title":"Cross-tissue developmental differentiation","description":"The terms cluster around developmental and differentiation processes across multiple tissues (heart/cardiac muscle development, hematopoietic/immune lineage differentiation, pancreatic cell development, and germline/pole cell formation). This suggests a broad theme of tissue development and cell lineage specification rather than a single, cohesive pathway. The obsolete GO entry should be ignored in interpretation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":1},{"id":"GO:0007507","count":1},{"id":"GO:0061049","count":1},{"id":"GO:0033077","count":1},{"id":"GO:0071425","count":1}]},{"hash":"2064047612663261938","title":"Cardiac development and stress-response signaling","description":"This cluster\u2019s top GO terms are dominated by cardiac-related processes (cardiac muscle hypertrophy in response to stress; heart development) and signaling regulation (dephosphorylation and negative regulation of kinase activity), with supporting terms on cell shape and cell cycle. While a few terms hint at neural aspects, the overall pattern points to proteins involved in cardiac development and stress-responsive signaling pathways.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014898","count":3},{"id":"GO:0006470","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0008360","count":2}]},{"hash":"76082713722596964","title":"Multitissue Development and Organogenesis","description":"The top GO terms are dominated by broad developmental processes across multiple tissues (forebrain, neural tube, retina, skeletal system, and general multicellular organism development). This suggests the cluster represents genes involved in tissue and organ formation, rather than a single specific pathway. Some terms related to cell cycle and stress responses appear but are secondary to the developmental theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0001403","count":3},{"id":"GO:0060041","count":3}]},{"hash":"345244512789562208","title":"Muscle development and sarcomere organization","description":"The top GO terms strongly point to muscle biology, with clear emphasis on sarcomere organization, skeletal muscle fiber development, and skeletal muscle cell differentiation. Swimming as a phenotype also aligns with muscular function, while ubiquitin-dependent protein catabolic and regulatory processes can be broadly involved in cellular maintenance. Taken together, the cluster seems best represented by a muscle development/sarcomere organization theme.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0045214","count":4},{"id":"GO:0036268","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0019762","count":4}]},{"hash":"2164083538452299299","title":"Embryonic Development and Organ Morphogenesis","description":"Examining the top GO terms, most are linked to developmental processes and tissue morphogenesis: pancreatic development, cartilage morphogenesis, endocrine system development, left-right pattern formation, and EMT-related heart development. Although a few entries pertain to transcriptional regulation or ribosome export, the dominant signal is differentiation and shaping of tissues during embryogenesis. Thus, a concise label for this cluster is Embryonic Development and Organ Morphogenesis.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":3},{"id":"GO:0003323","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2}]},{"hash":"658972775444349199","title":"Embryonic development and morphogenesis","description":"The cluster's top GO terms cluster around developmental processes and tissue formation: endocardial cushion EMT, cartilage morphogenesis, placenta development, trophoblast differentiation, left-right patterning, and endocrine system development, including pancreatic cell development. The presence of translation and mRNA splicing terms suggests concurrent regulation of gene expression during development. Overall, this cluster seems to group proteins involved in embryogenesis and organ morphogenesis rather than a single molecular function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0003323","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0060536","count":1}]},{"hash":"566928837650067347","title":"Innate Immune Response and Antimicrobial Peptide Production","description":"This cluster centers on GO terms related to production of inflammatory mediators, chemokines, and antimicrobial peptides, pointing to a role in innate immune signaling and antimicrobial defenses. Obsolete or broad terms about histone acetylation and chromatin remodeling suggest transcriptional regulation components, while carbohydrate metabolism and chitin catabolism appear as less central or housekeeping aspects. Taken together, the dominant theme is immune response and antimicrobial peptide production.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002532","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0043967","count":1}]},{"hash":"263153932057886650","title":"Endocytosis and vesicle trafficking regulation","description":"This cluster centers on terms governing endocytosis and vesicle trafficking, including receptor-mediated endocytosis and synaptic vesicle exocytosis, as well as related signaling processes such as Rho and Ras pathways and PI signaling. The recurring theme is the regulation of membrane dynamics in conjunction with signal transduction, which can span neuronal and developmental contexts (e.g., glutamatergic transmission, myoblast fusion). While some terms are peripheral (cell division), the dominant shared function appears to be control of vesicle trafficking and associated signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007520","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0035249","count":1}]},{"hash":"1535551286119729770","title":"Muscle development and extracellular matrix remodeling","description":"This cluster centers on processes related to muscle tissue development and its surrounding extracellular matrix, including uterine smooth muscle contraction, cardiac muscle development, and regulation of smooth muscle migration, as well as chondrocyte development and endochondral bone morphogenesis with ECM secretion. While some terms touch broader developmental timing and circulatory regulation, the core signal is tissue development and matrix remodeling in muscle/connective tissues.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048505","count":2},{"id":"GO:0051387","count":2},{"id":"GO:0070471","count":2},{"id":"GO:0061049","count":2},{"id":"GO:0003331","count":2}]},{"hash":"953041403322516240","title":"Endosomal Trafficking in Neurons","description":"The top GO terms cluster around endosomal and ESCRT-related processes (multivesicular body assembly, endosome transport to Golgi/lysosome, ESCRT-mediated viral budding) with a neuronal context (dendrite development, vesicle regulation). This suggests the proteins participate in neuronal endosomal trafficking and vesicle handling, making the label specific to this function.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036258","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1023264749281839916","title":"Developmental patterning and morphogenesis","description":"The terms point to broad developmental processes and tissue patterning (rostral-caudal neural tube patterning, head morphogenesis, planar polarity, Wnt/TGF signaling, pigment and bristle formation). While some terms seem diverse (eye pigmentation, short-term memory), they can fit under a shared theme of developmental patterning and morphogenesis across tissues. Confidence: Medium","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048069","count":1},{"id":"GO:0007614","count":1},{"id":"GO:0090251","count":1},{"id":"GO:0035622","count":1},{"id":"GO:0048104","count":1}]},{"hash":"1465618077258704707","title":"Virus-host translation and virion assembly","description":"This cluster is strongly enriched for translation and cytosolic ribosome assembly, pointing to ribosome-related functions. It also includes terms tied to viral biology, such as virion assembly, proviral latency, and host-driven activation of viral genome replication, which together suggest a collective role in virus\u2013host interactions and viral replication processes. Some other terms, like lipid droplet organization, may reflect host-cell pathways co-opted by viruses. Confidence: High","confidence":"","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0042256","count":2},{"id":"GO:2000276","count":1},{"id":"GO:0000413","count":1}]},{"hash":"1092117461271099265","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":3}]},{"hash":"1578251673388997221","title":"Bacterial quinone biosynthesis and catabolic metabolism","description":"The top GO terms cluster around biosynthesis of quinones (menaquinone, phylloquinone) and various catabolic/bioenergetic pathways (fatty acid beta-oxidation, phenylacetate and L-valine catabolism) along with antibiotic biosynthesis. This suggests a bacterial metabolic module centered on energy production and secondary metabolite biosynthesis rather than signaling or regulatory processes, justifying a label focused on quinone biosynthesis and related metabolism.","confidence":"Medium","size":8,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":7},{"id":"GO:0042372","count":7},{"id":"GO:0006635","count":7},{"id":"GO:0017000","count":7},{"id":"GO:0010124","count":7}]},{"hash":"2251223054748250259","title":"Detox metabolism and growth signaling","description":"The cluster\u2019s GO terms center on metabolic detoxification (glutathione metabolism; xenobiotic catabolic process) and lipid or growth-related signaling (prostaglandin biosynthesis; ERK cascade regulation; insulin response; growth regulation). While terms are diverse, they collectively point to proteins involved in processing chemicals and coordinating signaling pathways that influence cell growth and responses to stimuli. This justifies a label around detox/metabolic processing intertwined with signaling and growth regulation.","confidence":"Medium","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006749","count":2},{"id":"GO:0042178","count":1},{"id":"GO:2000030","count":1},{"id":"GO:0035264","count":1},{"id":"GO:1902476","count":1}]},{"hash":"1722267603114736857","title":"Xenobiotic Stress Response and Translation Regulation","description":"The cluster\u2019s top GO terms center on detox and xenobiotic responses (response to toxic substance, response to xenobiotic stimulus, response to ethanol) with accompanying translation-related terms (translation, negative regulation of translation) and mitochondrial energy activity (mitochondrial ATP synthesis). This suggests a coherent theme where cells mount a detox/chemical stress response while tuning protein synthesis and energy metabolism. Some terms are obsolete, but the core signal points to xenobiotic/toxin response coupled with translation regulation.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009636","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0007568","count":2}]},{"hash":"1804655711472854903","title":"Golgi trafficking and synaptic neurotransmission","description":"The top GO terms cluster around ER-to-Golgi vesicle transport and protein retention in the Golgi, indicating a core role in intracellular trafficking. Some terms point to neural signaling (glycinergic/dopaminergic transmission and glycine secretion), suggesting proteins linked to membrane trafficking that modulates neural communication. Placental development and axis specification appear more peripheral, but the dominant theme is Golgi-based transport with neural signaling components.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0001893","count":2},{"id":"GO:0007311","count":2},{"id":"GO:0045053","count":2},{"id":"GO:1903346","count":1}]},{"hash":"447801194006093683","title":"Kinetochore and centriole mitosis regulators","description":"Core terms point to protein localization to kinetochore, centriole replication, and regulation of CDK activity\u2014hallmarks of mitotic machinery. Other terms touch on neural development and signaling, likely reflecting multifunctional proteins or broader tissue roles, but the primary signal is assembly/regulation of the mitotic apparatus.","confidence":"High","size":8,"edges":25,"triangles":41,"max_degree":7,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034501","count":6},{"id":"GO:0045736","count":6},{"id":"GO:0048679","count":5},{"id":"GO:0021697","count":5},{"id":"GO:2001275","count":5}]},{"hash":"1889882498457915870","title":"Diverse nutrient and metabolite transport","description":"The top GO terms cluster around transmembrane transport of a variety of substrates (trehalose, urate, fructose, sialic acid, phosphate, vitamins, xenobiotics, etc.) across the plasma membrane, with an additional note on glucose starvation response, suggesting a transporter module for diverse nutrients under metabolic stress.","confidence":"High","size":8,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":5},{"id":"GO:0006855","count":5},{"id":"GO:0015747","count":5},{"id":"GO:0042149","count":5},{"id":"GO:1990539","count":5}]},{"hash":"15324833876993759","title":"ER-Golgi trafficking and organelle contact","description":"This cluster is dominated by GO terms tied to intracellular membrane trafficking, notably ER-to-Golgi vesicle transport, ER-mitochondria membrane tethering, and regulation of vesicle exocytosis, suggesting a core function in membrane trafficking and organelle contact. The presence of other terms such as androgen receptor signaling, dopaminergic neuron differentiation, and bone resorption appears less coherent with this theme, likely reflecting annotation noise or multifunctional proteins. Overall, the strongest signal is for vesicle trafficking and ER\u2013organelle interactions.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0030521","count":5},{"id":"GO:0010514","count":5},{"id":"GO:1990456","count":5},{"id":"GO:0046330","count":5}]},{"hash":"216203935474328183","title":"Ribosome biogenesis and protein secretion","description":"Top GO terms indicate a core focus on translation, ribosome biogenesis, and rRNA methylation, pointing to protein synthesis, with protein secretion suggesting involvement in processing/export of nascent proteins. While other terms touch on nucleotide sugar metabolism and envelope-associated biosynthesis, the dominant theme is ribosome/translation paired with secretion, supporting this label. ","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009306","count":2},{"id":"GO:0031167","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0001843","count":1}]},{"hash":"878328982577082365","title":"Mitotic Cell Cycle and Embryonic Development","description":"The top GO terms cluster around mitosis and cell division (mitotic cell cycle, mitotic cytokinesis, meiotic metaphase chromosome alignment) along with proliferation and early development (cell population proliferation, in utero embryonic development) and related processes like proteasomal regulation and membrane dynamics, suggesting proteins involved in cell division with developmental roles. High confidence. ","confidence":"High","size":8,"edges":5,"triangles":2,"max_degree":3,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0030154","count":4},{"id":"GO:0008283","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0032436","count":2}]},{"hash":"1976211010935754631","title":"Translation Machinery and Cell Cycle","description":"This cluster centers on protein synthesis and cell-cycle activities. GO terms strongly feature translation (translation, cytoplasmic translation, translational termination, translational fidelity) and cell-cycle/division processes, with a few skeletal muscle terms suggesting tissue-specific context. Overall, the common theme is translation-related machinery intertwined with cell-cycle regulation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0045903","count":1},{"id":"GO:0000349","count":1},{"id":"GO:0006415","count":1},{"id":"GO:0006412","count":1}]},{"hash":"833482554481907133","title":"Axon guidance and neural development signaling","description":"Based on the enriched GO terms, the cluster centers on neural development and axon guidance. Terms like axon guidance, nervous system development, Roundabout signaling pathway, and related signaling cascades (ERK, Rho) point to neuronal connectivity and patterning. While there are also immune and other developmental signals present, the strongest thematic signal is neural guidance and development, making this a concise and representative label.","confidence":"High","size":8,"edges":22,"triangles":25,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0035023","count":5}]},{"hash":"380146247100319048","title":"DNA Replication and Genome Maintenance","description":"The top GO terms cluster around DNA metabolism: DNA replication and primer synthesis, DNA repair, recombination, and plasmid maintenance, with a note of helicase regulation. While there are a couple of peripheral terms (mitochondrial complex assembly and Rac/microtubule regulation), the dominant signal is genome maintenance and replication, suggesting proteins involved in DNA metabolism and genetic element maintenance.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030420","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0033617","count":2},{"id":"GO:0035021","count":2},{"id":"GO:0031117","count":2}]},{"hash":"2001323211174892544","title":"Brain and Eye Development","description":"The top GO terms cluster around neural and ocular formation (brain development, subpallium neuron fate commitment, spinal cord neuron fate specification, camera-type eye development, embryonic eye morphogenesis), with transcriptional regulation by RNA polymerase II further supporting coordinated developmental gene expression. While some terms touch on broader morphogenesis (bronchiole development, epithelial tube branching), the dominant theme is neuro-ocular development. ","confidence":"High","size":8,"edges":9,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0043010","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0060441","count":5},{"id":"GO:0021520","count":4}]},{"hash":"868995145347954477","title":"Ion Transport and Neuromuscular Signaling","description":"This cluster is enriched for ion transport terms (potassium, sodium, manganese, calcium) and for regulation of muscle contraction and synaptic plasticity (LTP/LTD), suggesting a theme of ionic homeostasis linked to neuromuscular signaling and cell communication. A single term about larval cuticle development may reflect species-specific annotation rather than the core function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0098735","count":1},{"id":"GO:0010163","count":1},{"id":"GO:0097369","count":1},{"id":"GO:0060292","count":1}]},{"hash":"504600241424185068","title":"Synaptic Transmission and Active Zone Organization","description":"This cluster is enriched for GO terms related to neurotransmission and synapse architecture, including regulation of excitatory and inhibitory postsynaptic potentials, acetylcholine catabolic process in the synaptic cleft, receptor internalization, and cytoskeletal matrix organization at the active zone, as well as terminal button organization. These point to proteins involved in synaptic signaling and the structural organization of presynaptic active zones and postsynaptic sites. Some terms like retina development or osteoblast development appear but likely reflect broader developmental roles; the dominant signal is neuronal synapse function.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":5},{"id":"GO:0002076","count":5},{"id":"GO:0002087","count":5},{"id":"GO:0072553","count":4},{"id":"GO:2000463","count":4}]},{"hash":"724849987406403491","title":"DNA replication and telomere maintenance","description":"The top terms point to core DNA replication processes (DNA replication, replication fork progression, RNA primer removal in mitotic replication, DNA recombination) and regulation of telomere maintenance by telomerase. A few entries reference mitochondrial genome maintenance, but the dominant signal is replication and telomere-associated functions.","confidence":"High","size":8,"edges":11,"triangles":5,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051974","count":2},{"id":"GO:0097046","count":2},{"id":"GO:1902983","count":2}]},{"hash":"626754801081100515","title":"Retroviral Integration and Latency","description":"The prominent GO terms cluster around reverse transcription (RNA-templated DNA synthesis), DNA integration, and DNA replication/recombination, which together describe a retroviral life cycle involving synthesis of proviral DNA and integration into the host genome, followed by establishment of latency. Additional terms refer to entry into the host cell and nucleus, supporting a viral infection/latency theme.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0090502","count":4},{"id":"GO:0043137","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0046718","count":4}]},{"hash":"2198129794944399013","title":"Unknown","description":"The annotated functions are scattered across calcium-NFAT signaling, transcription termination and RNA processing, plus DNA damage/silencing terms, with several obsolete GO entries. This mix does not reveal a single cohesive biological theme for the cluster, so Unknown is the safest label.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051533","count":1},{"id":"GO:0051209","count":1},{"id":"GO:0006369","count":1},{"id":"GO:0010526","count":1},{"id":"GO:0070940","count":1}]},{"hash":"1827209866423644860","title":"Neural development and synaptic signaling","description":"The cluster is enriched for nervous system development, neurogenesis, regulation of synaptic vesicle exocytosis, and axon guidance signals (Roundabout signaling). These terms indicate proteins involved in neuronal differentiation, synaptic transmission, and cytoskeletal regulation (Rho signaling). A single outlier term (T cell receptor signaling) does not outweigh the overall neural theme.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010796","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0035385","count":3}]},{"hash":"1252338265452527944","title":"ER-Golgi trafficking and COPI vesicle formation","description":"The top terms point to the secretory pathway: ER-to-Golgi vesicle transport, COPI coat/budding, protein exit from ER, and Golgi ribbon formation, plus ER retention, all indicating a cohesive module of ER\u2013Golgi trafficking and secretion (with a single less-connected mitochondrial import term as an outlier).","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":2},{"id":"GO:0045040","count":2},{"id":"GO:0061357","count":1},{"id":"GO:0035964","count":1},{"id":"GO:0048042","count":1}]},{"hash":"642692689612124142","title":"Muscle contraction and sarcomere organization","description":"The top GO terms are dominated by sarcomere organization, muscle contraction, and muscle stretch response, along with calcium-mediated signaling and muscle activity, which together point to a cohesive muscle fiber structure and function theme. Some terms about development or ER stress appear incidental but do not override the core muscle-related pattern.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0035584","count":2},{"id":"GO:0006936","count":2},{"id":"GO:0035994","count":2},{"id":"GO:0043931","count":2}]},{"hash":"151622399077075765","title":"Nucleotide Salvage and Cofactor Biosynthesis","description":"The Top Terms show clear signals for nucleotide salvage (CMP, UMP, uracil salvage) and pyrimidine metabolism, as well as biosynthetic processes for cofactors NAD+ and CoA, plus general phosphorylation. This suggests a cluster centered on recycling nucleotides and producing key cofactors, i.e., nucleotide salvage coupled with cofactor biosynthesis.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009435","count":1},{"id":"GO:0046939","count":1},{"id":"GO:0044211","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0046940","count":1}]},{"hash":"1541756600005972124","title":"Neural and retinal development signaling","description":"This cluster centers on neural development and eye-related signaling pathways. Terms like neurogenesis, nervous system development, and retina morphogenesis point to a neural/visual development theme, while ERK cascade, Hedgehog (Smoothened), and ROBO signaling reflect growth-factor and axon guidance routes shaping neural tissues. FGFR signaling involved in orbitofrontal cortex development further supports a brain development focus; occasional kidney development and sarcomere organization terms appear as broader or incidental associations. Overall, the dominant pattern links neural and retinal development signaling.","confidence":"Medium","size":8,"edges":15,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0022008","count":4}]},{"hash":"828850122486273790","title":"Gonadal and reproductive organ development","description":"These proteins show enrichment for GO terms tied to development of reproductive organs, including female genitalia development, uterus development, and female gonad development (and prostate gland growth). While a few terms (potassium ion response, inflammatory regulation, nematode response) are less central, the reproductive-development terms strongly suggest the cluster\u2019s primary theme.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030540","count":3},{"id":"GO:0002677","count":3},{"id":"GO:0060736","count":3},{"id":"GO:0035865","count":3},{"id":"GO:0090350","count":3}]},{"hash":"1242959926831020494","title":"Oxidative Stress Response and Redox Homeostasis","description":"The cluster is enriched for GO terms related to redox processes and oxidative stress responses, including cellular redox homeostasis, cellular oxidant detoxification, and DNA-templated transcription, pointing to roles in managing cellular redox balance and responding to oxidative challenges. A few terms (e.g., uracil catabolic process, nicotinamide metabolic process) suggest broader metabolic connections, and a couple of outliers (like male gonad development) may be annotation noise. Overall, the dominant signal supports a redox-focused function for the cluster.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019740","count":2},{"id":"GO:0006212","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1138987978373360275","title":"Retroviral integration and proviral latency","description":"These terms point to viral genome integration and proviral latency, including reverse transcription (RNA-templated DNA biosynthesis), DNA recombination/replication, and host-pathogen interactions (entry into the nucleus, RNAi suppression, apoptosis modulation). The combination strongly suggests retroviral-like integration machinery and latency establishment rather than general cellular DNA processing.","confidence":"High","size":8,"edges":6,"triangles":1,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0015074","count":6},{"id":"GO:0075732","count":5},{"id":"GO:0046718","count":5},{"id":"GO:1903704","count":5}]},{"hash":"223254233333868384","title":"Embryonic development and morphogenesis","description":"The cluster\u2019s top GO terms cluster around developmental processes and tissue patterning during embryogenesis\u2014left/right pattern formation, cartilage morphogenesis, endocardial cushion EMT, placental differentiation, endocrine system development, and pancreatic cell development\u2014suggesting a shared role in embryonic organogenesis. While mRNA splicing and protein ubiquitination are general cellular processes present, the prominent theme is developmental morphogenesis and lineage specification.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0000209","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1585580402998204465","title":"Lipid catabolism and xenobiotic response","description":"The cluster is enriched for lipid-related catabolic processes (triglyceride and monoacylglycerol catabolism) and cholesterol biosynthesis, with additional signals of xenobiotic and toxic substance responses and endocannabinoid signaling regulation. While a few terms are less cohesive (e.g., cellulose catabolic process), the dominant pattern points to lipid metabolism intertwined with detoxification/response to xenobiotics, defining the cluster\u2019s theme.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0019433","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0071375","count":2},{"id":"GO:0052651","count":2}]},{"hash":"265242999284537978","title":"Nervous system and muscle development","description":"This cluster shows enrichment across nervous system\u2013related processes (retinal ganglion and motor neuron axon guidance, forebrain/cerebellum development, visual perception) and muscular/cardiac development (skeletal and ventricular cardiac muscle development, heart development) as well as thyroid development, suggesting a broad developmental program spanning multiple tissues rather than a single pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":2},{"id":"GO:0030878","count":2},{"id":"GO:0055015","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0007601","count":2}]},{"hash":"1298643694342122298","title":"Unknown","description":"The top GO terms span very different biological themes (Notch signaling, NOD2 pathway, oligodendrocyte differentiation, thermoception, pinocytosis) with no single unifying function for the cluster. This makes it unclear what shared role ties these proteins together, so a general Unknown label is appropriate.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0032088","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0003270","count":2},{"id":"GO:0044707","count":2}]},{"hash":"779891074156587202","title":"Adrenergic GPCR Signaling and Heart-Rate Regulation","description":"The cluster\u2019s top GO terms center on adrenergic and adenosine receptor\u2013mediated GPCR signaling, with downstream cAMP/cGMP pathways influencing heart rate, smooth muscle contraction and hormone secretion. Additional terms link to feeding and grooming behaviors, pointing to coordinated signaling linked to cardiovascular and behavioral regulation via adrenergic and GPCR pathways.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060259","count":5},{"id":"GO:0001996","count":5},{"id":"GO:0007199","count":5},{"id":"GO:0045986","count":5},{"id":"GO:0007625","count":5}]},{"hash":"1288356722764203900","title":"Lipid and Aromatic Compound Metabolism","description":"This cluster centers on lipid breakdown (triglyceride and monoacylglycerol catabolism) and aromatic compound degradation (beta-ketoadipate pathway), with additional links to bioplastic PHB biosynthesis and various stress/ signaling responses (strigolactone response, response to toxic substances) as well as antibiotic biosynthesis. The shared theme is metabolic processing of lipids and aromatic molecules, along with regulatory stress-related responses, suggesting a cohesive metabolic remodeling cluster.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":3},{"id":"GO:1902348","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0052651","count":2}]},{"hash":"647805339372355415","title":"Unknown","description":"The top GO terms are highly diverse, ranging from pheromone response and smell to social behavior, transport, and various lipid/sterol metabolic processes (including fungal ergosterol biosynthesis) and even unrelated mammalian terms. With no coherent biological theme and no edges connecting proteins, there is no clear unifying function for this cluster.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0006675","count":1}]},{"hash":"206308589440054603","title":"Xenobiotic Detoxification and Stress-Response Regulation","description":"The proteins cluster around xenobiotic metabolism (xenobiotic catabolic process, antibiotic response) and amino acid catabolism (phenylalanine/tyrosine), with accompanying protein ubiquitination and transcriptional regulation, suggesting a coordinated detoxification and stress-response module that modulates gene expression and protein turnover under xenobiotic/stress conditions.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0006357","count":2},{"id":"GO:0042178","count":2}]},{"hash":"2071458503975500504","title":"Neural-immune signaling and myelination","description":"The top GO terms emphasize innate immune response and cytokine production alongside neural development processes such as axonal fasciculation and myelination, suggesting a cluster of proteins at the interface of neuroimmune signaling and nervous system maturation. This combination supports a cohesive theme around neural-immune interactions and myelination rather than a purely one-function group.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":3},{"id":"GO:0032474","count":3},{"id":"GO:0032689","count":3},{"id":"GO:0002374","count":3},{"id":"GO:0045087","count":3}]},{"hash":"2234714809287014483","title":"Nuclear RNA processing and cell cycle","description":"The top GO terms cluster around nuclear functions: DNA-templated transcription, mRNA splicing, mRNA transport, and rRNA maturation, along with cell division and mitotic cell cycle regulation and nuclear export control. These together point to a set of proteins involved in coordinating gene expression and cell cycle processes within the nucleus; the neural development terms appear ancillary. ","confidence":"High","size":7,"edges":17,"triangles":17,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0055114","count":2}]},{"hash":"1192042078429377870","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0000381","count":2}]},{"hash":"313320261610057982","title":"Lipid biosynthesis and remodeling","description":"The terms are dominated by lipid biosynthesis and remodeling (CDP-diacylglycerol, phosphatidylcholine, cardiolipin, triglycerides, ether lipids, cutin) and a mitochondria-related energy process (mitochondrial ATP synthesis). Developmental terms (cerebellum morphogenesis, glandular epithelial cell maturation) suggest lipids\u2019 role in membrane formation and cellular differentiation, rather than a single signaling pathway. Overall, the cluster centers on lipid metabolism and membrane composition with links to energy production.","confidence":"Medium","size":7,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016024","count":6},{"id":"GO:0002071","count":6},{"id":"GO:0036151","count":6},{"id":"GO:0035965","count":6},{"id":"GO:0019432","count":6}]},{"hash":"1146427757999492555","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":17,"triangles":21,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050689","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0006364","count":4},{"id":"GO:0034474","count":4},{"id":"GO:0045433","count":4}]},{"hash":"687274818022827228","title":"GTPase Regulation and Endocytic Trafficking","description":"This cluster centers on regulation of small GTPase activity, endocytosis, and lysosome localization, with supportive signals from TOR pathway regulation and ciliary transport, suggesting a role in membrane trafficking and GTPase-driven signaling, potentially in neuronal contexts like mushroom body development.","confidence":"Medium","size":7,"edges":13,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016319","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0000186","count":2},{"id":"GO:0006897","count":2}]},{"hash":"1840404788694874479","title":"Xenobiotic and nutrient membrane transport","description":"This cluster is driven by transmembrane transport GO terms, including xenobiotic and vitamin transport, potassium ion transport, and related export processes (teichoic acid, bacteriocin immunity, oligopeptide export), suggesting a cohesive function in transporting diverse small molecules across membranes, often in bacterial contexts.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0042908","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0042891","count":3}]},{"hash":"518463253653760501","title":"Embryonic development and cell cycle regulation","description":"The cluster is driven by developmental processes (multicellular organism development, embryonic cranial skeleton morphogenesis) and cell cycle/DNA replication activities (DNA replication, positive regulation of nuclear cell cycle DNA replication, centrosome cycle, DNA-templated transcription). While some terms hint at neural signaling (cellular response to dopamine, sensory perception of pain), these appear less central to the dominant pattern. Therefore, a label reflecting both development and cell cycle control best captures the cluster\u2019s core functions.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0001666","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0010571","count":2},{"id":"GO:0007098","count":2}]},{"hash":"1049521258777285160","title":"Diverse plasma membrane solute transport","description":"These proteins are enriched for GO terms describing transport across the plasma membrane for a variety of substrates (trehalose, fructose, urate, sialic acid, phosphate, organic anions, vitamins, selenite) and a cellular response to glucose starvation, suggesting a common function as diverse solute transporters at the cell surface.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":7},{"id":"GO:0006855","count":7},{"id":"GO:0015747","count":7},{"id":"GO:0042149","count":7},{"id":"GO:1990539","count":7}]},{"hash":"115126429305910381","title":"Virus-host interaction and immune modulation","description":"The cluster\u2019s GO terms point to processes involved in viral manipulation of the host and immune system, including host-mediated activation of viral replication, suppression of MHC II biosynthesis, autophagy regulation, and general mRNA turnover and protein complex stability\u2014collectively suggesting roles in virus\u2013host interactions and immune evasion/modulation.","confidence":"Medium","size":7,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0044829","count":1},{"id":"GO:0045347","count":1},{"id":"GO:0000289","count":1},{"id":"GO:0016239","count":1},{"id":"GO:0061635","count":1}]},{"hash":"2246283699043278302","title":"Neuronal signaling and sensory perception","description":"The cluster shows strong representation of neural-related GO terms: dopaminergic synaptic transmission, visual and pain perception, and behavioral responses to drugs like cocaine, all pointing to neural signaling and sensory processing. Additional terms like ERK cascade and prostaglandin response fit within neuronal signaling contexts. While a few terms are broader (transcription, heart development), the predominant theme is neuronal communication and perception.","confidence":"High","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0007507","count":4}]},{"hash":"856808617960810692","title":"Neuronal signaling, memory, and circadian regulation","description":"The GO terms are dominated by brain-related functions: excitatory postsynaptic potential, calcium/sodium/potassium ion transport (neural excitability), long-term memory, and responses to amphetamine, plus circadian sleep/wake cycle. While skeletal muscle development appears, the majority points to neuronal signaling and memory/circadian processes, suggesting a neural function cluster with some peripheral muscle annotation. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0010800","count":2},{"id":"GO:0006816","count":2}]},{"hash":"947153794839854810","title":"Growth and Cell Cycle Regulation","description":"The top GO terms cluster around cell division and DNA processes (cell division, DNA strand elongation, meiotic sister chromatid cohesion) and also include growth-related developmental processes across tissues (root meristem growth, meristem maintenance, intestinal epithelial structure maintenance, hair cycle). The presence of regulatory terms for metabolism and signaling (positive regulation of glucose import, nitric-oxide synthase activity) further supports a coordinated growth/regulatory role. Together these suggest a cluster of proteins involved in controlling proliferation and tissue development rather than a single specialized pathway.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0051754","count":2},{"id":"GO:0032092","count":1},{"id":"GO:0022616","count":1},{"id":"GO:0042635","count":1}]},{"hash":"1675210732802130836","title":"Golgi-ER vesicle trafficking and synaptic receptor insertion","description":"The dominant GO terms center on ER-to-Golgi and Golgi-to-endosome/ plasma membrane transport, Golgi ribbon formation, and exocytic insertion of neurotransmitter receptors, plus regulation of Golgi organization and surface localization. Together these indicate a cluster of proteins involved in secretory vesicle trafficking through the Golgi-ER axis and delivery of receptors to the synaptic membrane, with associated neurotransmitter release processes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0090161","count":3},{"id":"GO:0033194","count":2},{"id":"GO:2000010","count":2},{"id":"GO:2000463","count":2}]},{"hash":"1131622009608593121","title":"Reproductive organ development","description":"The top GO terms are dominated by developmental processes for reproductive organs (female genitalia development, uterus development, female gonad development, and related organ growth), suggesting the proteins cluster around reproductive organ development and differentiation. A few regulatory and ion/immune-related terms appear but are secondary to the main theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030540","count":4},{"id":"GO:0002677","count":4},{"id":"GO:0060736","count":4},{"id":"GO:0035865","count":4},{"id":"GO:0090350","count":4}]},{"hash":"1758466182619923118","title":"Embryonic organogenesis and neural development","description":"The GO terms point to diverse developmental programs spanning neural differentiation (midbrain, hypothalamus, subthalamic nucleus) and other organogenesis processes (odontogenesis, hepatoblast differentiation, gonadal mesoderm, somatotropin-secreting pituitary cells). The common thread is broad developmental differentiation across multiple tissues, rather than a single, cohesive pathway. ","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0021763","count":4},{"id":"GO:0042663","count":4},{"id":"GO:0042475","count":4}]},{"hash":"1353519330778508755","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms cluster around forebrain development, placenta/uterus-related development, cartilage morphogenesis, and EMT in heart development, suggesting a common theme of embryogenesis and tissue differentiation across multiple organs; a few terms like cellular response to insulin stimulus appear incidental.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":2},{"id":"GO:0009952","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0032869","count":2}]},{"hash":"2060513305512658968","title":"Negative regulators of signaling and synaptic function","description":"Top GO terms indicate broad involvement in negative regulation of signaling pathways (MAPK/ERK cascade, PI3K/AKT, T cell receptor signaling) alongside processes related to synaptic organization (postsynaptic density assembly, synaptic vesicle clustering) and habituation. This suggests a cluster of proteins that primarily dampen signaling and modulate synaptic function and learning-related processes.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":7},{"id":"GO:0050860","count":7},{"id":"GO:0000200","count":7},{"id":"GO:2000808","count":6},{"id":"GO:0051898","count":6}]},{"hash":"1851588013296063046","title":"Redox Homeostasis and Oxidative Stress Response","description":"The cluster is dominated by GO terms related to oxidation-reduction processes, cellular redox homeostasis, and detoxification of oxidants, including removal of superoxide radicals and peptidyl-cysteine oxidation. These point to a common theme of maintaining redox balance and defending against oxidative stress, with a few peripheral terms (methylamine metabolism, lipoprotein biosynthesis, erythrocyte homeostasis) that may reflect related metabolic or transport contexts. Overall, the redox-focused signals justify the label.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0030416","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0007252","count":3}]},{"hash":"672412017932330864","title":"Sugar metabolism and nucleotide biosynthesis","description":"The GO terms show a cohesive theme of sugar catabolism and nucleotide-related processes, including N-acetylneuraminate and ribose metabolism, the pentose phosphate shunt (non-oxidative branch), and uridine biosynthesis, suggesting a link between carbohydrate utilization and nucleotide production.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019262","count":2},{"id":"GO:0006098","count":2},{"id":"GO:0042838","count":1},{"id":"GO:0046176","count":1},{"id":"GO:0009089","count":1}]},{"hash":"400319584454327894","title":"T cell development and cytokine signaling","description":"This cluster is enriched for thymus development, NK T cell differentiation, and interleukin-4 production, pointing to involvement in T cell lineage development and cytokine-mediated signaling. Additional terms such as ERK/MAPK cascades, JNK activation, and actin filament binding suggest coordinated signaling and cytoskeletal changes that accompany T cell activation.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071226","count":7},{"id":"GO:0032633","count":7},{"id":"GO:0007257","count":7},{"id":"GO:0048538","count":7},{"id":"GO:0001865","count":7}]},{"hash":"491333870393397235","title":"Lipid Biosynthesis and Adipogenesis","description":"The cluster is dominated by GO terms tied to lipid metabolism (response to fatty acid, sphingosine biosynthetic process, monounsaturated fatty acid biosynthetic process, cholesterol esterification) and adipocyte development (white fat cell differentiation), suggesting a coherent function in lipid production and adipogenesis. Some terms reflect gland-related lipid secretion or barrier biology (tarsal gland development, regulation of water loss via skin), which are related but secondary to the core theme of lipid biosynthesis and adipogenesis.","confidence":"High","size":7,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":4},{"id":"GO:0033561","count":3},{"id":"GO:0046512","count":3},{"id":"GO:1903699","count":3},{"id":"GO:1903966","count":3}]},{"hash":"717781294626423139","title":"Mitochondrial Energy Metabolism and Protein Regulation","description":"The terms repeatedly point to mitochondrial energy metabolism (mitochondrial electron transport, ubiquinol to cytochrome c; aerobic respiration) and protein regulation (heterooligomerization; negative regulation of proteolysis), with broader signals from hormone/catabolic processes and lifespan. Some terms are broad or obsolete, but the dominant signal centers on mitochondrial energy production and related protein regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0051291","count":4},{"id":"GO:0016032","count":3},{"id":"GO:1901143","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0045861","count":3}]},{"hash":"516319933214393676","title":"Embryonic Morphogenesis and Patterning","description":"The top GO terms cluster around developmental morphogenesis and patterning (left/right axis formation, cartilage/hair follicle/palate morphogenesis, endocardial cushion EMT), indicating proteins involved in embryonic tissue formation; a few terms refer to ribosome export or transcriptional regulation, but the dominant signal is embryonic development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":3},{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0031069","count":2}]},{"hash":"1843368164833509811","title":"Neural signaling and sensory development","description":"The cluster is dominated by GO terms related to neural communication and sensory pathways, including cholinergic synaptic transmission, action potential generation, and signaling via serotonin and GABA, as well as sensory organ development (cochlea, optic nerve). Skeletal muscle contraction and norepinephrine signaling also fit within the broader neuromuscular/sensory theme. A few outliers (e.g., acrosome reaction) are present, but the overall pattern centers on neural signaling and sensory development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007271","count":7},{"id":"GO:0001508","count":7},{"id":"GO:2000344","count":7},{"id":"GO:0007210","count":7},{"id":"GO:0090102","count":7}]},{"hash":"310100997643271203","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for maturation of rRNA components (SSU and LSU from tricistronic transcripts) and core translation processes (translation, translational initiation, termination), with additional signals for RNA surveillance and no-go decay. A couple of terms (in utero embryonic development, JNK cascade) suggest broader regulatory roles or annotation breadth, but the central theme is ribosome assembly and protein synthesis control. ","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0007254","count":2},{"id":"GO:0070966","count":1}]},{"hash":"509678598086725996","title":"Transmembrane Transporters","description":"Proteins in this cluster show a strong tilt toward transmembrane transport activities: multiple GO terms for ion transport (potassium, sodium), nitrate/nitrite and phosphate transport, xenobiotic transport, and even neurotransmitter loading into synaptic vesicles. The common thread is membrane transport function, with a few metabolism-related terms that may reflect coupled processes or multifunctionality. ","confidence":"Medium","size":6,"edges":8,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0006855","count":1},{"id":"GO:0035435","count":1},{"id":"GO:0098700","count":1},{"id":"GO:0015706","count":1}]},{"hash":"538469272426644550","title":"Diverse membrane transporter proteins","description":"These terms center on transmembrane transport of many substrates\u2014xenobiotics, vitamins, sugars, and ions\u2014and include vesicular neurotransmitter loading, pointing to a cluster of transporter proteins with broad substrate specificity rather than a single substrate pathway.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0035435","count":3},{"id":"GO:0098700","count":3}]},{"hash":"1586267272308917616","title":"Microbial energy metabolism and motility","description":"This cluster centers on microbial energy production pathways, including aerobic respiration, TCA cycle, fermentation, methanogenesis, and even photosynthesis, with accompanying flagellum assembly and motility terms, suggesting a cohesive theme of motile microbes harnessing various energy sources.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0022904","count":2},{"id":"GO:0071973","count":2},{"id":"GO:0044780","count":2},{"id":"GO:0009060","count":2}]},{"hash":"1232888478440601292","title":"Vesicle trafficking and secretory pathway components","description":"The top GO terms include COPII-coated vesicle budding, positive regulation of the regulated secretory pathway, and Rab protein signal transduction, pointing to a core theme of vesicle formation, trafficking, and secretion. While other terms in the set are more diverse (e.g., development and signaling), they appear less represented, suggesting the main functional thread is vesicle trafficking and secretory regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":2},{"id":"GO:0000001","count":1},{"id":"GO:0048714","count":1},{"id":"GO:1903307","count":1},{"id":"GO:0060661","count":1}]},{"hash":"1106470062604141251","title":"Diverse Plasma Membrane Transporters","description":"GO terms indicate broad membrane transport activity across the plasma membrane for a range of substrates: trehalose, urate, fructose, sialic acid, phosphate, vitamins, selenite, organic anions, and responses to glucose starvation. The common thread is solute transport across the cell boundary, suggesting these proteins function as diverse transporters involved in nutrient uptake and xenobiotic handling, especially under nutrient stress.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":5},{"id":"GO:0006855","count":5},{"id":"GO:0015747","count":5},{"id":"GO:0042149","count":5},{"id":"GO:1990539","count":5}]},{"hash":"1914423290381372431","title":"Neuronal translation and synaptic signaling","description":"The cluster is dominated by neural-related GO terms: translation and translational initiation point to protein synthesis machinery, while excitatory postsynaptic potential, cholinergic synaptic transmission, postsynaptic membrane organization, and action potential indicate synaptic function and neuronal signaling. A couple of terms (osteoblast differentiation and acrosome reaction) are less connected, but the prevailing theme centers on neuronal protein synthesis linked to synaptic activity, justifying this label.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006413","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0001649","count":2}]},{"hash":"1804720857720583032","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are dominated by translation (GO:0006412) and ribosome biogenesis (GO:0042254), including small and large subunit biogenesis and rRNA maturation, indicating proteins involved in ribosome assembly and the protein synthesis machinery. A few related terms (e.g., response to antibiotic, protein stabilization) are ancillary and do not outweigh the core ribosome-focused theme. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0042254","count":3},{"id":"GO:0006407","count":2},{"id":"GO:0042274","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1198488380696681467","title":"Translation Machinery and Ribosome Dynamics","description":"The high-frequency GO terms are centered on translation and ribosome-related processes: translation, translational termination, elongation, and ribosome disassembly, plus regulation of translational fidelity. This points to a cluster of proteins involved in protein synthesis and ribosome turnover. The presence of RNA processing-related terms (mRNA decay, RNA-templated transcription) suggests coupling to RNA metabolism. A few terms (glial cell proliferation, heterochromatin regulation) are less directly connected and may reflect secondary associations.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0014009","count":2},{"id":"GO:1902802","count":2},{"id":"GO:0001172","count":2},{"id":"GO:0045903","count":2}]},{"hash":"1265852588330070507","title":"Xenobiotic Detoxification and Aldehyde Metabolism","description":"This cluster centers on responses to external chemicals (xenobiotics, LPS) and on catabolic pathways that process aldehydes, polyols, and alcohols (formaldehyde, furaldehyde, ethanol, sorbitol, xylitol), suggesting a cohesive theme of detoxification and chemical metabolism. Some terms (like roof of mouth development) appear as noise, but the dominant signals point to handling xenobiotics and related metabolites.","confidence":"Medium","size":6,"edges":8,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0060021","count":2},{"id":"GO:0002098","count":2}]},{"hash":"1327561223901043959","title":"Mitochondrial dynamics and autophagy","description":"The top GO terms cluster around mitochondrial processes\u2014mitochondrial fusion, membrane organization, and inheritance\u2014plus macroautophagy, suggesting a focus on mitochondrial structure and turnover. Some vesicle trafficking terms (clathrin-dependent endocytosis, endocytic recycling) may reflect shared membrane trafficking roles or multifunctional proteins, but the dominant signal is mitochondria-associated dynamics and autophagy. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":3},{"id":"GO:0072583","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0048662","count":2},{"id":"GO:0060976","count":2}]},{"hash":"840908477019487742","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001680","count":1},{"id":"GO:0042245","count":1},{"id":"GO:0006378","count":1},{"id":"GO:1990180","count":1},{"id":"GO:0010815","count":1}]},{"hash":"168600372692361543","title":"Neuronal Signaling and Synaptic Calcium Regulation","description":"The GO terms point to neural communication (neuropeptide signaling), synaptic organization and development (receptor clustering, dendritic spine regulation, BDNF receptor signaling), and calcium signaling (store-operated calcium entry) with downstream physiological effects such as heart rate modulation and NO signaling, suggesting a cohesive theme around neuronal signaling and synaptic function. Some terms touch broader endocrine contexts (adrenal development) or germ cell proliferation, but the core cluster appears to center on neural signaling and synaptic regulation.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010460","count":1},{"id":"GO:0007218","count":1},{"id":"GO:2001256","count":1},{"id":"GO:0010751","count":1},{"id":"GO:0002176","count":1}]},{"hash":"2196219048088228009","title":"DNA Repair and Transcription","description":"The proteins in this cluster are enriched for DNA repair functions (homologous recombination, nucleotide excision repair) and transcription-related processes (DNA-templated transcription, RNA Pol II promoter clearance), with an additional link to cell cycle/spindle orientation. This combination points to a core theme of genome integrity maintenance coupled with transcriptional regulation, even though a few terms (e.g., rolling circle replication, viral protein processing) may reflect broader or context-specific roles. ","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048568","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000724","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0030433","count":2}]},{"hash":"1557926711549290811","title":"Actin remodeling and developmental signaling","description":"Top GO terms indicate actin cytoskeleton remodeling via Arp2/3\u2013mediated nucleation, along with regulation of kinase and GTPase activities and several development-related terms. This suggests a cohesive theme of actin-driven remodeling connected to developmental signaling processes, justifying the label. ","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032508","count":3},{"id":"GO:0071902","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0021762","count":2}]},{"hash":"1288418408393559232","title":"Unknown","description":"The GO terms are spread across inflammation/immunoregulatory processes, metabolism, development, and other disparate cellular activities, with no clear shared function or pathway and no edges linking the proteins, making a coherent cluster label unsupported.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002532","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0006032","count":1},{"id":"GO:0090197","count":1},{"id":"GO:0032088","count":1}]},{"hash":"2283928617539877996","title":"Plant flavonoid and lignin biosynthesis","description":"This cluster\u2019s top GO terms center on anthocyanin and kaempferol flavonoid biosynthesis, flavonoid-related modifications, and lignin metabolism, all core components of the plant phenylpropanoid pathway. There are also related terms about antibiotic biosynthesis and genistein response, which can reflect defense-associated secondary metabolism. A few annotations (e.g., paranode axon localization) appear as outliers or cross-species noise, but the dominant signal supports flavonoid and lignin biosynthesis as the unifying theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":6},{"id":"GO:0009718","count":5},{"id":"GO:0071412","count":5},{"id":"GO:0030259","count":5},{"id":"GO:0009808","count":5}]},{"hash":"550795993201884112","title":"Telomere Maintenance Regulation and Localization","description":"The top GO terms concentrate on telomere biology\u2014both positive and negative regulation of telomere maintenance via telomerase and telomere localization to chromosome ends, plus related processes like PARP activity and transcriptional regulation at telomeres. While a few terms (e.g., certain developmental pathways) are broader or peripheral, the core themes consistently point to telomere maintenance and localization, suggesting a cohesive telomere-focused cluster.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070198","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0070212","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007205","count":2}]},{"hash":"290761067024226330","title":"Neural signaling and neuromuscular function","description":"This cluster is dominated by GO terms tied to neuronal communication and motor control, including cholinergic synaptic transmission, postsynaptic membrane organization, serotonin signaling, action potential, neuromuscular posture control, and cochlear development, pointing to a common theme of neural signaling and motor coordination. Some terms like gamma-carboxylation and vitamin K metabolism appear less directly connected but do not override the main neural-focused theme.","confidence":"Medium","size":6,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0017187","count":1},{"id":"GO:0010207","count":1},{"id":"GO:0042373","count":1},{"id":"GO:0007271","count":1},{"id":"GO:0001508","count":1}]},{"hash":"1742716452709924447","title":"NF-kB\u2013Mediated Immune Regulation","description":"The terms are dominated by immune signaling and inflammatory regulation: positive regulation of canonical NF-kappaB signaling, negative regulation of inflammatory response, and suppression of IL-4 production and type 2 immunity, plus ubiquitination and IgG isotype-switching connections\u2014consistent with a cluster centered on immune signaling modulation. A few metabolic/ion-transport terms may reflect immunometabolic links but do not override the core immune theme.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1904960","count":1},{"id":"GO:0008535","count":1},{"id":"GO:0033132","count":1},{"id":"GO:0099132","count":1},{"id":"GO:0048302","count":1}]},{"hash":"601797843992642526","title":"Lipid biosynthesis and adipocyte differentiation","description":"This cluster is dominated by GO terms related to lipid metabolism: sphingosine biosynthetic process, monounsaturated fatty acid biosynthetic process, response to fatty acid, and white fat cell differentiation. While a few terms are obsolete or less directly connected (e.g., tarsal gland development, photoinhibition), the strongest recurring theme across the terms is lipid biosynthesis and adipocyte differentiation, suggesting the proteins function in lipid production and fat cell formation.","confidence":"High","size":6,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033561","count":2},{"id":"GO:0046512","count":2},{"id":"GO:1903699","count":2},{"id":"GO:1903966","count":2},{"id":"GO:0034435","count":2}]},{"hash":"2192164007061280454","title":"Negative Regulation of ERAD, Autophagy, and Endocytosis","description":"The top GO terms cluster around suppressing ER-associated degradation, autophagosome maturation, endocytosis, GPCR internalization, and related signaling pathways, suggesting a common theme of dampening intracellular protein quality control and membrane trafficking processes. Some terms (nucleotide-excision repair, spindle pole duplication) appear as outliers or broader annotations, but the dominant pattern supports this label.","confidence":"Medium","size":6,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0006289","count":2},{"id":"GO:0034140","count":2},{"id":"GO:1900186","count":2},{"id":"GO:1901097","count":2}]},{"hash":"2081692088640559756","title":"N-terminal Protein Acetylation","description":"The top GO terms are dominated by several N-terminal acetylation events (peptidyl-methionine/glutamic acid acetylation, propionylation, and related modifications), suggesting involvement of NAT-like activity or protein modification at the N-terminus. While there are additional biosynthetic/catabolic terms (ectoine, mycothiol, arginine, acetoin), the acetylation theme is strongest and most cohesive for naming this cluster.","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":3},{"id":"GO:0061606","count":3},{"id":"GO:0045150","count":3},{"id":"GO:0018002","count":3},{"id":"GO:0046208","count":3}]},{"hash":"1950241096881928764","title":"RNA Pol II Transcription Regulation","description":"The dominant terms are transcription by RNA polymerase II and negative regulation of transcription by RNA polymerase II, pointing to a shared role in controlling gene expression at the transcriptional level. The other terms reflect diverse developmental contexts and may indicate multifunctionality, but the core signal is transcriptional regulation by RNA Pol II.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0060749","count":1},{"id":"GO:0060153","count":1},{"id":"GO:0072015","count":1}]},{"hash":"834741776069312386","title":"Brain signaling and sensory perception","description":"This cluster is enriched for neural signaling and sensory-related GO terms, including brain renin-angiotensin system, visual learning and visual perception, dopaminergic synaptic transmission, cocaine-related behavioral responses, and ERK cascade regulation, suggesting a cohesive theme around central nervous system signaling, sensory processing, and reward/addiction pathways. The presence of a broader term like heart development and macrophage chemotaxis is less consistent but may reflect shared signaling pathways or developmental links.","confidence":"Medium","size":6,"edges":12,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002035","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0007601","count":3}]},{"hash":"560700581731426197","title":"N-terminal acetylation and related PTMs","description":"The top GO terms are dominated by N-terminal acetylation-related activities (peptidyl-glutamic acid acetylation, peptidyl-methionine acetylation, peptidyl-lysine N6-acetylation, and N-terminal propionylation), suggesting enzymes that transfer acetyl groups to protein N-termini or adjacent substrates. Additional terms point to acetyl-transfer\u2013driven biosynthetic pathways (mycothiol, ectoine) and other acetylation-associated metabolism (e.g., arginine biosynthesis, acetoin catabolism). Together these indicate a cohesive group of N-acetyltransferases and related modifications, with some breadth into small-molecule acetyl biosynthesis; hence the label reflects the cluster\u2019s shared theme more than individual pathways.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":6},{"id":"GO:0061606","count":6},{"id":"GO:0045150","count":6},{"id":"GO:0018002","count":6},{"id":"GO:0046208","count":6}]},{"hash":"724157963196361021","title":"RNA processing and ribonucleoprotein assembly","description":"Dominant GO terms indicate involvement in RNA processing and maturation: mRNA splicing via spliceosome, spliceosomal complex assembly, maturation of SSU-rRNA, and tRNA processing, plus P-body assembly which relates to mRNA metabolism. The combination points to a cluster of proteins primarily engaged in post-transcriptional RNA processing and ribonucleoprotein complexes, with some ancillary stress response terms.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0006369","count":3},{"id":"GO:0042633","count":3},{"id":"GO:0009414","count":3},{"id":"GO:0000245","count":3}]},{"hash":"703669121487022397","title":"RNA splicing and translation regulation","description":"The cluster shows strong signals for mRNA processing and splicing (spliceosome regulation and splice-site recognition) along with post-transcriptional tail regulation (poly(A) tail shortening/polyadenylation) and translation control (IRES-dependent initiation and translation reinitiation). A couple of terms related to development or stress (hypoxia, axis specification) are present but do not dominate the theme. Overall, the core is RNA processing and translation regulation.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0071230","count":3},{"id":"GO:0006376","count":3},{"id":"GO:0060213","count":3}]},{"hash":"939197397718731084","title":"Mitotic centromere assembly and ER-Golgi transport","description":"The top terms strongly point to mitotic processes (CENP-A chromatin assembly, cell division, microtubule severing) while also highlighting vesicle trafficking between the ER and Golgi (anterograde and retrograde transport, ERAD-related pathway). This suggests a cluster of proteins involved in both chromosome segregation during mitosis and membrane trafficking, justifying a label that reflects both themes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0051028","count":2},{"id":"GO:0006890","count":2}]},{"hash":"167241315271333912","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019079","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0000027","count":4},{"id":"GO:0071031","count":3},{"id":"GO:0048026","count":3}]},{"hash":"1099711683459402422","title":"Stress-responsive RNA processing and translation control","description":"A small cluster with GO terms centered on post-transcriptional regulation: splicing regulation, splice site recognition, and poly(A) tail shortening, plus translation initiation/reinitiation and IRES-dependent translation, all in the context of a cellular response to hypoxia. This suggests a theme of coordinating RNA processing with translation under stress. Some terms (like oocyte axis specification) seem less connected, so the label focuses on the core RNA processing/translation regulation under hypoxic conditions.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0048026","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0006376","count":2}]},{"hash":"398530173419217761","title":"Unknown","description":"These terms span ubiquitin-related proteostasis and trafficking, but also translation, DNA repair, neuronal development, and immune signaling, with no single cohesive function tying all terms together.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0021888","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0010636","count":3}]},{"hash":"1031436765845123447","title":"Quinone biosynthesis and core metabolism","description":"The cluster shows strong enrichment for quinone biosynthetic processes (phylloquinone and menaquinone) and central carbon metabolism (glyoxylate and oxaloacetate pathways), with additional biosynthetic and regulatory terms (antibiotic biosynthesis, response to cAMP). This points to a cohesive theme around quinone production and key metabolic intermediates, with some broader metabolic connections.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042372","count":2},{"id":"GO:0009436","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0051591","count":2}]},{"hash":"1443974637870964119","title":"Amino acid biosynthesis and sulfur metabolism","description":"The cluster\u2019s top GO terms cluster around amino acid biosynthesis (D-serine, L-cysteine via cystathionine, L-tryptophan, pyruvate biosynthesis) and related amine/amine catabolic processes, plus hydrogen sulfide biosynthesis. This points to a cohesive theme of amino acid metabolism, especially sulfur-containing amino acids, with a secondary note of broader amine turnover. Some terms are obsolete or tangential (e.g., morphine response), but the core signal supports amino acid biosynthesis and metabolism.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070179","count":2},{"id":"GO:0019343","count":2},{"id":"GO:0009310","count":2},{"id":"GO:0018871","count":2},{"id":"GO:0043278","count":2}]},{"hash":"73556581446410747","title":"Embryonic Morphogenesis and Lineage Differentiation","description":"This cluster centers on broad developmental processes across multiple tissues, including heart morphogenesis (atrial septum, cardioblast differentiation), nervous system branching, kidney/ureter development, and hematopoietic/immune lineage differentiation (embryonic hemopoiesis, megakaryocyte and pro-T cell differentiation). The common theme is embryonic organogenesis and lineage specification rather than a single pathway, so a high-level label reflecting multi-tissue development is appropriate.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0003290","count":5},{"id":"GO:0033600","count":5},{"id":"GO:0030219","count":5},{"id":"GO:0048485","count":5},{"id":"GO:0048755","count":5}]},{"hash":"1634131390877788422","title":"Heat stress and protein quality control","description":"The cluster is dominated by terms related to heat response and proteostasis, including response to heat, chaperone-mediated protein complex assembly, detection of misfolded protein, and protein stabilization. These point to a cohesive function in maintaining protein folding and stability under stress, i.e., a heat-stress chaperone network. Some inflammatory cytokine terms appear peripherally but do not define the core motif of this cluster.","confidence":"High","size":5,"edges":8,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":1},{"id":"GO:0052212","count":1},{"id":"GO:2000778","count":1},{"id":"GO:0050821","count":1},{"id":"GO:0051301","count":1}]},{"hash":"369944364149629379","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster centers on ubiquitin tagging and proteasome-mediated turnover, including K11- and K48-linked ubiquitination and SCF/APC/C-dependent proteolysis. Neddylation supports Cullin ligases; ERAD and general ubiquitin-dependent catabolic processes are also represented, indicating a cohesive protein-degradation theme relevant to cell division.","confidence":"High","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070979","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0045116","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0031145","count":2}]},{"hash":"982825140363387379","title":"Innate and adaptive immune response","description":"Based on GO terms, the cluster shows enrichment for innate immune response, production of inflammatory mediators, and positive regulation of chemokine production, pointing to immune signaling and inflammation. The presence of V(D)J recombination suggests adaptive immunity as well. Some terms like carbohydrate metabolism and development are less central and may reflect background processes or annotation noise. Overall, an immune-related cluster is most representative.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045676","count":1},{"id":"GO:0006511","count":1},{"id":"GO:1903215","count":1},{"id":"GO:0007275","count":1},{"id":"GO:0002532","count":1}]},{"hash":"249838368659727173","title":"Developmental branching morphogenesis and neural maturation","description":"The GO terms converge on developmental signaling and morphogenesis, notably branching in salivary gland morphogenesis, plus broader tissue development cues (FGF receptor signaling), alongside neural development/differentiation facets (nerve maturation, juxtaparanode localization, Na channel clustering). This suggests a multi-tissue developmental theme with a core emphasis on branching morphogenesis and neural maturation.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060665","count":2},{"id":"GO:0048661","count":2},{"id":"GO:0035607","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0045663","count":2}]},{"hash":"1510452324297500906","title":"Tissue-wide developmental differentiation","description":"This cluster\u2019s GO terms center on differentiation and morphogenesis across diverse tissues (carotid body glomus cells, arterial endothelium, trochlear nerve, myoblasts, somitogenesis, pulmonary valve, etc.), indicating a general developmental program rather than a single tissue-specific function. Some terms (humoral immune response, transcription regulator region binding) are more regulatory or outliers, but the dominant theme is developmental differentiation across multiple tissues.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0061103","count":5},{"id":"GO:0060842","count":5},{"id":"GO:0021558","count":5},{"id":"GO:0045663","count":5},{"id":"GO:0048658","count":5}]},{"hash":"2032099550874924934","title":"Neuronal stress response and protein homeostasis","description":"The top GO terms emphasize stress signaling (stress-activated MAPK cascade, response to heat), redox regulation (negative regulation of ROS), proteostasis (protein stabilization, amyloid fibril regulation), and neuronal transport (anterograde axonal protein transport). Muscle contraction and high-light response are ancillary but fit within broader cellular stress/adaptation contexts. Overall, the cluster seems to reflect neuronal cellular stress responses and protein quality control rather than a single pathway.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":3},{"id":"GO:0051403","count":2},{"id":"GO:2000378","count":2},{"id":"GO:0099641","count":2},{"id":"GO:0050821","count":2}]},{"hash":"1689092516441307109","title":"Insect larval chemical sensing and pheromone signaling","description":"These proteins appear linked to insect larval chemical detection and social communication, with GO terms for smell and taste perception (sweet and bitter), pheromone response, and social behavior, plus larval cuticle development. Other terms (transport and ER-related processes) reflect general cellular roles that may be secondary to the core sensory/pheromone-related functions. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0019236","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0006810","count":1}]},{"hash":"503205207460095559","title":"Embryonic development and organogenesis","description":"Top GO terms show broad involvement in developmental patterning and tissue morphogenesis across multiple organs (heart, cartilage, placenta, pancreas, lens, melanosomes, forebrain). This suggests the cluster represents genes/proteins participating in embryonic development and organogenesis rather than a single molecular function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060707","count":2}]},{"hash":"1094520520239531633","title":"Ubiquitin-mediated regulation of the cell cycle and apoptosis","description":"The cluster shows strong signals for ubiquitination processes (polyubiquitination; K48- and K63-linked ubiquitination) and APC/C-dependent protein turnover, coupled with negative regulation of cell cycle and apoptotic pathways, and broader regulatory roles in transcription and necroptosis as well as TLR signaling. This points to a cohesive theme where ubiquitin tagging governs protein stability to restrain cell growth, cell cycle progression, and cell fate decisions, with ancillary roles in immune signaling.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060544","count":2}]},{"hash":"845298640467265762","title":"Neuronal GPCR Signaling and Synaptic Regulation","description":"The top terms are dominated by neuronal signaling and GPCR/cAMP pathways (action potential; adenylate cyclase\u2013activating/inhibiting GPCR signaling; positive/negative regulation of synaptic transmission), indicating a core theme of neuronal communication and synaptic modulation. While there are some unrelated terms (ER stress, development-related processes, copper homeostasis), the strongest common thread among the proteins appears to be GPCR-mediated signaling and synaptic regulation in neurons.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001508","count":5},{"id":"GO:0034976","count":5},{"id":"GO:0000743","count":5},{"id":"GO:0071880","count":5},{"id":"GO:0050805","count":5}]},{"hash":"702700944249089527","title":"ER-Golgi vesicle transport and GTPase signaling","description":"This cluster centers on vesicle trafficking between the ER and Golgi (COPII loading and ER-to-Golgi transport) and small GTPase signaling (Rap activation, GTPase activity), which together suggest a coherent theme of trafficking regulation. While a few terms touch immune signaling or cell cycle processes, the dominant signals point to vesicle transport and GTPase-regulated communication. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0046007","count":2},{"id":"GO:0032486","count":1},{"id":"GO:1902953","count":1},{"id":"GO:0044829","count":1}]},{"hash":"204215051180383145","title":"Nematode Embryogenesis and Fertilization Regulation","description":"The terms cluster around embryonic development and fertilization control (maternal axis specification, embryonic morphogenesis, polyspermy prevention) plus nematode-specific processes like molting and cuticle proteolysis, indicating a developmental/reproductive theme in nematodes. A vertebrate fin morphogenesis term appears but does not override the overall pattern.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043050","count":2},{"id":"GO:0007313","count":2},{"id":"GO:2000360","count":2},{"id":"GO:0048632","count":2},{"id":"GO:0035124","count":2}]},{"hash":"836493194331834555","title":"RNA processing and translation control","description":"This cluster centers on mRNA processing activities (splicing, splice-site recognition, and poly(A) tail regulation) and translational regulation (initiation, reinitiation, and IRES-dependent initiation). The GO terms collectively point to RNA maturation and control of protein synthesis, rather than a single canonical pathway. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006376","count":3},{"id":"GO:0060211","count":3},{"id":"GO:0002188","count":3}]},{"hash":"2265059911888053196","title":"Heat-stress response and protein quality control","description":"The cluster centers on proteotoxic stress responses: heat stress, detection of misfolded proteins, and chaperone/complex assembly, along with protein stabilization. While several terms point to stress-induced inflammatory signaling (IL-6, TNF), most items converge on maintaining protein homeostasis under stressful conditions, with some extras related to metal stress and cellular assembly processes.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0052212","count":4},{"id":"GO:2000778","count":4},{"id":"GO:0050821","count":4},{"id":"GO:0051301","count":4}]},{"hash":"606938396235487739","title":"Mevalonate-driven isoprenoid biosynthesis","description":"The top GO terms cluster around terpenoid and isoprenoid production: monoterpene, farnesyl diphosphate (FPP), geranyl/geranylgeranyl diphosphates, cholesterol, and quinone biosynthesis\u2014all connected to the mevalonate pathway. This suggests the proteins function together in prenylated lipid and terpenoid biosynthesis. Some ancillary terms (protein transport/heterotetramerization, viral entry) may be incidental noise rather than core signals.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043693","count":2},{"id":"GO:0006695","count":2},{"id":"GO:0033386","count":2},{"id":"GO:0033384","count":2},{"id":"GO:0015031","count":2}]},{"hash":"2019684398465283736","title":"Negative regulation of innate immune signaling","description":"Most terms describe downregulation or suppression of immune signaling pathways (negative regulation of IL-8, NOD2, TLR3, CD40 signaling; tolerance to LPS; B cell homeostasis). Deubiquitination terms (K33/K63-linked) are regulatory mechanisms for these pathways, supporting the theme of dampening inflammation. A single term on larval cuticle development appears incidental noise rather than a defining function of the cluster.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:1990168","count":1},{"id":"GO:0002677","count":1},{"id":"GO:0070536","count":1},{"id":"GO:0032717","count":1}]},{"hash":"2122643910344766563","title":"Adrenergic and Adenosine GPCR Signaling in Heart and Behavior","description":"The GO terms point to a cohesive GPCR signaling theme through adrenergic and adenosine receptors, linking cAMP/cGMP signaling to heart rate control, smooth muscle regulation, and behavioral processes such as grooming and feeding, suggesting a tightly connected neuromodulatory pathway.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060259","count":1},{"id":"GO:0001996","count":1},{"id":"GO:0007199","count":1},{"id":"GO:0045986","count":1},{"id":"GO:0007625","count":1}]},{"hash":"1508760768602626886","title":"Adrenergic and Adenosine GPCR Signaling in Heart and Behavior","description":"The GO terms cluster around GPCR signaling with adrenergic and adenosine receptors, affecting heart rate, smooth muscle contraction, and hormone secretion, with additional links to feeding and grooming behaviors. The presence of both adenylate cyclase-activating and -inhibiting adrenergic pathways supports a unified ADR/adenosine GPCR signaling theme influencing cardiovascular and neural regulation.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060259","count":3},{"id":"GO:0001996","count":3},{"id":"GO:0007199","count":3},{"id":"GO:0045986","count":3},{"id":"GO:0007625","count":3}]},{"hash":"374009883500936027","title":"Wnt signaling and APC-dependent proteolysis","description":"This cluster's terms center on canonical and non-canonical Wnt signaling (including planar cell polarity) and APC-/proteasome-associated protein degradation, suggesting a theme of signaling interconnected with cell-cycle\u2013related proteolysis. Other terms like viral process or cadmium response are less representative.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090090","count":4},{"id":"GO:0038061","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0051436","count":4}]},{"hash":"106440458555941487","title":"Dopaminergic Synaptic Signaling and Membrane Organization","description":"This cluster centers on neuronal signaling, notably dopaminergic synaptic transmission, and membrane-related processes such as localization to membrane rafts and adhesion molecule regulation. Although several terms are obsolete or broad, the strongest signals point to synaptic signaling and membrane organization in neurons.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0060355","count":3},{"id":"GO:0032226","count":3},{"id":"GO:1901585","count":3}]},{"hash":"9902757932978459","title":"Glycolysis, Gluconeogenesis, and Energy Metabolism","description":"Reasoning: The majority of top GO terms point to central carbon metabolism\u2014glycolysis, fructose catabolic pathways, fructose 1,6-bisphosphate metabolism, and gluconeogenesis\u2014and to energy regulation (ATP-dependent activity) and V-type ATPase assembly. A few terms related to development appear to be noise, but the dominant signal is carbohydrate catabolism and energy production.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070072","count":1},{"id":"GO:0006094","count":1},{"id":"GO:0006116","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0061621","count":1}]},{"hash":"275479902281142281","title":"Proteostasis and energy regulation in muscle and neurons","description":"These terms cluster around protein turnover (ubiquitin/proteasome pathways and ERAD), translation, and energy/calcium management (mitochondrial fusion, ATPase-coupled calcium transport), which relate to muscle contraction control and muscle atrophy, as well as neural development contexts. A stray developmental term is present, but the dominant signal points to protein homeostasis and energy regulation in muscle and neuronal contexts.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0086004","count":4},{"id":"GO:0014889","count":4},{"id":"GO:0021888","count":4},{"id":"GO:1901896","count":4}]},{"hash":"191105303347985607","title":"Chromatin remodeling and meiotic recombination regulation","description":"This cluster centers on chromatin organization and meiotic chromosome events, with supporting signals from synaptonemal complex organization, positive regulation of meiotic recombination, and ubiquitin-related processes (K48 and K63 linked). The combination suggests roles in chromatin dynamics during meiosis and ubiquitin-mediated regulation of DNA repair and recombination, despite a few obsolete terms in the set.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031497","count":4},{"id":"GO:1901487","count":4},{"id":"GO:1990920","count":4},{"id":"GO:0070936","count":4},{"id":"GO:0010845","count":4}]},{"hash":"1382278980669507094","title":"Membrane Solute Transporters","description":"The cluster shows multiple GO terms for transmembrane transport of various solutes (trehalose, urate, fructose, sialic acid, vitamins, xenobiotics, selenite, organic anions) and related metabolic responses, suggesting a group of membrane transporter proteins handling diverse small molecules across the plasma membrane; the larval cuticle development term is a weaker, possibly incidental connection. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0015771","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0015747","count":1},{"id":"GO:0042149","count":1}]},{"hash":"2130851852889460641","title":"Diverse Substrate Membrane Transporters","description":"All proteins in this cluster share transmembrane transport across the plasma membrane with a broad range of substrates (trehalose, urate, fructose, phosphate, sialic acid, vitamins, xenobiotics, selenite). The GO terms converge on transport activity rather than a single substrate, suggesting a group of diverse substrate membrane transporters. The cellular response to glucose starvation may reflect transporter regulation under nutrient stress, reinforcing the transport-focused function.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0015747","count":4},{"id":"GO:0042149","count":4},{"id":"GO:1990539","count":4}]},{"hash":"1224658515340508959","title":"Heat Stress and Protein Quality Control","description":"The terms point to a core heat response with misfolded-protein detection, chaperone-mediated assembly, and protein stabilization, i.e., cellular protein quality control under stress. Additional terms for metal stress and cytokine production suggest broader stress signaling, but the folding/chaperone theme remains the dominant signal.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0052212","count":4},{"id":"GO:2000778","count":4},{"id":"GO:0050821","count":4},{"id":"GO:0051301","count":4}]},{"hash":"116792460273744259","title":"Embryonic Tissue Development","description":"The top GO terms point to development across multiple tissues: hippocampus development and forebrain proliferation (neural development), lens fiber cell differentiation and melanosome organization (eye/pigment cells), melanocyte migration (pigment cells), angiogenesis (vasculature), and EMT in endocardial cushion formation (heart development). While there is some regulation of proteasomal degradation and gene expression, the common theme is broad embryonic tissue development and differentiation across organs rather than a single pathway.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":2},{"id":"GO:0097324","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0021766","count":2},{"id":"GO:0006349","count":2}]},{"hash":"1826515930767707551","title":"Adrenergic GPCR Signaling and Cardiac Regulation","description":"These proteins are linked to GO terms centered on adrenergic receptor signaling (GPCR pathways), downstream cAMP/adenylate cyclase and cGMP signaling, and physiological outputs such as increased heart rate, modulation of vascular smooth muscle, and hormone secretion. The convergent theme is adrenergic GPCR-mediated control of cardiovascular and related secretory functions, with some behavioral associations (grooming). This makes \"Adrenergic GPCR Signaling and Cardiac Regulation\" an intuitive, specific label for the cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060259","count":1},{"id":"GO:0001996","count":1},{"id":"GO:0007199","count":1},{"id":"GO:0045986","count":1},{"id":"GO:0007625","count":1}]},{"hash":"2242589320416504824","title":"Muscle fiber development and sarcomere assembly","description":"These proteins are enriched for GO terms related to sarcomere organization, skeletal muscle thin filament assembly, and skeletal muscle fiber development, indicating a core function in muscle fiber formation and contractile apparatus assembly. Additional terms on mitosis and endocytosis may reflect shared components, but the dominant theme is muscle structure formation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":4},{"id":"GO:0000001","count":4},{"id":"GO:0030240","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0002121","count":4}]},{"hash":"55492899910769519","title":"Nuclear Migration and Mitotic Microtubule Dynamics","description":"This set centers on microtubule-driven processes: plus-end directed microtubule sliding, centrosome separation during mitosis, mitotic chromosome handling, and nuclear migration along microtubules (including karyogamy-related migration). Although a couple of terms touch on adherens junctions or development, the dominant theme is cytoskeletal dynamics governing nuclear movement and cell division. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045218","count":4},{"id":"GO:0048364","count":4},{"id":"GO:0007100","count":4},{"id":"GO:0031535","count":4},{"id":"GO:0000743","count":4}]},{"hash":"1215508743258256530","title":"Transmembrane Ion and Metabolite Transport","description":"The GO terms show strong representation for transmembrane and ion transport (Na+, K+, monoatomic anions) and specific metabolite transport (citrate, succinate, malate), plus regulation of phosphate transport. This points to a cluster of membrane transporter proteins that move ions and small metabolites across membranes, rather than enzymes or signaling components. The combination of general transport terms with specific metabolite transport supports a coherent transport function for these proteins.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0055085","count":1},{"id":"GO:2000185","count":1},{"id":"GO:0006813","count":1},{"id":"GO:0015746","count":1}]},{"hash":"1275931489071198140","title":"Cell Division and Nuclear Transport","description":"The proteins appear enriched for processes tied to the cell cycle and nucleocytoplasmic transport: cell division, centriole- and chromatid cohesion, nuclear pore complex assembly, and mRNA transport. While a few terms touch on development or neuronal differentiation and cardiac regulation, these are less represented. The core theme centers on mitosis/meiosis control and RNA export/import, suggesting a cluster of cell cycle and nuclear transport factors.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0051028","count":2},{"id":"GO:0048364","count":2},{"id":"GO:0016339","count":2},{"id":"GO:0042176","count":2}]},{"hash":"300532002152063219","title":"DNA Repair and Recombination","description":"The dominant GO terms are DNA repair-related: DNA recombination (GO:0006310) and base-excision repair (GO:0006284), indicating genome maintenance as the cluster's core function. Several secondary terms touch signaling or stress responses (e.g., xenobiotic stimulus, peptide hormone response) but are less central. This combination suggests a DNA damage repair/genome stability theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:1903507","count":2},{"id":"GO:0046856","count":2},{"id":"GO:2000466","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1979396551007593273","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by the GO term larval chitin-based cuticle development, with 4 proteins associated to this process, suggesting a cohesive role in larval cuticle synthesis/organization. No other major shared functions are evident in the top terms, so the label directly reflects the primary function represented.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4}]},{"hash":"964237817510385442","title":"Cellular detox and metabolic signaling","description":"Top GO terms are dominated by detoxification and xenobiotic metabolism (cellular oxidant detoxification; xenobiotic catabolic process) with additional links to lipid signaling (prostaglandin biosynthetic process) and growth regulation (multicellular organism growth; negative regulation of fibroblast proliferation; ERK cascade modulation). A few terms point to metabolic responsiveness (insulin signaling; manganese ion response) and transport functions (chloride transmembrane transport). Together, these terms suggest a cluster centered on cellular detoxification and related metabolic signaling, with ancillary roles in growth and signaling.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0042178","count":2},{"id":"GO:2000030","count":2},{"id":"GO:0035264","count":2},{"id":"GO:1902476","count":2}]},{"hash":"125992311355241920","title":"Embryonic eye and neural development","description":"The top GO terms point to developmental morphogenesis, especially eye/retina and neural tissues (optic nerve morphogenesis, retina morphogenesis, axial mesoderm formation). Additional terms about neuronal synaptic plasticity, myoblast differentiation, and cell migration fit within broad embryonic development programs. Overall, the cluster appears enriched for early developmental processes with a focus on ocular and neural tissue formation.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048320","count":2},{"id":"GO:0071372","count":2},{"id":"GO:0048170","count":2},{"id":"GO:0021631","count":2},{"id":"GO:0060060","count":2}]},{"hash":"1148864272151173893","title":"Fungal lipid metabolism and membrane biosynthesis","description":"The top GO terms cluster around lipid production and membrane composition, including unsaturated fatty acid biosynthesis, ergosterol biosynthesis regulation, and mannosyl-inositol phosphorylceramide metabolism, which are characteristic of fungal membranes. Protein insertion into membrane also supports this theme. Some terms are more general (nitric oxide, nitrate assimilation, myelin-related terms) but the dominant pattern is lipid synthesis and membrane assembly in a fungal context.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0032443","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0001949","count":2}]},{"hash":"1282790728291601609","title":"Immune and Wnt/NF-kB Signaling with Protein Turnover","description":"Based on the top GO terms, this cluster centers on signaling pathways: immune receptor signaling (stimulatory C-type lectin receptor), canonical and non-canonical Wnt signaling (both canonical and planar cell polarity), and NF-kappaB signaling, along with protein turnover processes (APC-dependent catabolic process and proteasomal degradation). The combination suggests a theme of signal transduction tightly linked to regulated protein turnover. Some terms also reflect stress or infection context (viral process, cadmium response), but the primary signal integration appears to be immune/Wnt/NF-kB signaling with degradation. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":2},{"id":"GO:0090090","count":1},{"id":"GO:0038061","count":1},{"id":"GO:0090263","count":1},{"id":"GO:0031145","count":1}]},{"hash":"672032871770500091","title":"Inflammation, coagulation, and tissue remodeling","description":"This cluster combines neutrophil-mediated defense, complement activation, coagulation/fibrinolysis, and signals of barrier integrity and tissue remodeling, pointing to a coordinated inflammatory vascular response rather than a single isolated pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0030901","count":2},{"id":"GO:1903142","count":1},{"id":"GO:0070947","count":1},{"id":"GO:0002542","count":1}]},{"hash":"95871401973604433","title":"Carbohydrate Catabolic Pathways","description":"Most terms point to carbohydrate metabolism and catabolic processing of various sugars (D-gluconate, D-xylose, L-fucose, L-arabinose), glycerol catabolism, and related phosphorylation steps. The mixed signals from quorum sensing and cellular response to interleukin-13 are noted but are less central; overall the shared theme is sugar metabolism and related catabolic routes. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019521","count":3},{"id":"GO:0042732","count":3},{"id":"GO:0046167","count":3},{"id":"GO:0035963","count":3},{"id":"GO:0042355","count":3}]},{"hash":"546602238992047349","title":"Neural-Sensory and Immune Signaling","description":"The GO terms point to neural and sensory signaling (chemical synaptic transmission, GABA signaling, bitter taste perception, cellular response to EGF) as well as immune-related signaling (IL-15-mediated signaling, B cell proliferation). Other terms touch on reproductive and vascular development, suggesting a broader signaling toolkit rather than a single pathway. The name captures the core theme of signaling across neural/sensory and immune contexts.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002322","count":3},{"id":"GO:2000344","count":3},{"id":"GO:0060716","count":3},{"id":"GO:0050913","count":3},{"id":"GO:0035723","count":3}]},{"hash":"1544707422348260185","title":"Methionine salvage and choline-betaine metabolism","description":"The top GO terms cluster around methionine salvage and choline/betaine pathways (L-methionine salvage, S-methylmethionine cycle, betaine/choline catabolism), suggesting a shared role in one-carbon/methyl group metabolism. A few outliers imply additional, less central roles but do not negate the core theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042426","count":1},{"id":"GO:0050666","count":1},{"id":"GO:0071267","count":1},{"id":"GO:0033528","count":1},{"id":"GO:0006579","count":1}]},{"hash":"599397552562268804","title":"Innate immunity and coagulation","description":"Top GO terms indicate neutrophil-mediated killing (fungi and gram-positive bacteria), classical complement activation, and coagulation/fibrinolysis (Factor XII activation, plasminogen activation, fibrinolysis), along with endothelial barrier regulation and tissue remodeling. This suggests a cohesive program where innate immune effector functions intersect coagulation pathways and vascular remodeling, supporting a label that captures both immune and coagulation aspects.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":1},{"id":"GO:0070947","count":1},{"id":"GO:0002542","count":1},{"id":"GO:0048771","count":1},{"id":"GO:0070946","count":1}]},{"hash":"2035831440944671139","title":"Unknown","description":"This cluster has no GO terms or interactions (no edges, no triangles, and none listed), so there is no discernible shared function to base a label on. Unknown is the safest, with no confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2126291505145352396","title":"Plasma Membrane Solute Transport","description":"The top GO terms show transport of diverse solutes across the plasma membrane (trehalose, urate, fructose, sialic acid, vitamins, xenobiotics, selenite, organic anions) with an additional note on cellular responses to nutrient stress, indicating a cluster of proteins functioning as membrane transporters for multiple substrates rather than a single substrate. An outlier term like metamorphosis doesn\u2019t disrupt the overall transporter-centered theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007552","count":1},{"id":"GO:0015771","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0015747","count":1},{"id":"GO:0042149","count":1}]},{"hash":"919095100027479609","title":"RNA splicing and translational regulation","description":"The top GO terms converge on mRNA processing (splicing, splice site recognition, export, stabilization, poly(A) tail regulation) and on various aspects of translation control (initiation, reinitiation, IRES-dependent initiation, helicase activity), suggesting a cluster centered on RNA metabolism linking processing with translation regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":1},{"id":"GO:0075522","count":1},{"id":"GO:0006376","count":1},{"id":"GO:0060211","count":1},{"id":"GO:0002188","count":1}]},{"hash":"1079269501704062982","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0048025","count":1},{"id":"GO:0001682","count":1},{"id":"GO:0000492","count":1}]},{"hash":"977463875396904519","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0090503","count":2},{"id":"GO:0070935","count":2},{"id":"GO:1901254","count":2},{"id":"GO:0010738","count":2}]},{"hash":"1457452706466169993","title":"Inner ear ion homeostasis and otolith mineralization","description":"This cluster is dominated by GO terms for ion homeostasis and transport (calcium, sodium, potassium, copper) alongside ear-specific processes (vestibulocochlear nerve formation, otolith mineralization), pointing to proteins involved in inner-ear ionic balance and otolith biomineralization rather than general cytosolic regulation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006874","count":2},{"id":"GO:0002028","count":2},{"id":"GO:0060003","count":2},{"id":"GO:0097623","count":2},{"id":"GO:0021650","count":2}]},{"hash":"1103067476642123156","title":"Stress Response and Protein Homeostasis","description":"The GO terms point to stress signaling and cellular maintenance, including a stress-activated MAPK cascade, heat response regulation, ROS control, amyloid fibril regulation, and protein stabilization. While there are some terms about axonal transport and muscle contraction, the dominant theme is how the proteins participate in stress response and preserving protein function, suggesting a cohesive but small cluster around stress adaptation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051403","count":1},{"id":"GO:2000378","count":1},{"id":"GO:0099641","count":1},{"id":"GO:0050821","count":1},{"id":"GO:1900034","count":1}]},{"hash":"2089534274589603216","title":"Larval chitin-based cuticle development","description":"The cluster\u2019s top GO term is larval chitin-based cuticle development, suggesting the proteins share involvement in forming or modifying the larval cuticle composed of chitin, a coherent functional theme despite few terms; this single term best captures the cluster\u2019s shared function.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"2096756953409951747","title":"Drosophila developmental transcription and chromatin regulation","description":"The cluster includes GO terms spanning developmental processes (larval cuticle, antennal, and eye development) and gene expression control (DNA-templated transcription, transcription regulation, spliceosome activity, chromatin remodeling/heterochromatin formation, dosage compensation). This suggests a cohesive theme of developmental transcriptional control and chromatin regulation in Drosophila, though the mix of terms broadens the context somewhat.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0010226","count":1},{"id":"GO:0000388","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0031453","count":1}]},{"hash":"1988628339822179432","title":"Ribosome maturation and translation under stress","description":"The strongest terms are about translation (GO:0006412) and regulation of translation (GO:0006417) and, notably, maturation of SSU-rRNA from the tricistronic transcript (GO:0000462), which points to ribosome biogenesis. Additional terms reference protein modification/repair and a response to oxidative stress, suggesting a cluster centered on basic protein synthesis machinery that functions or is modulated under stress conditions.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006464","count":1},{"id":"GO:0030091","count":1},{"id":"GO:0006979","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0000462","count":1}]},{"hash":"351819475025811661","title":"Unknown","description":"The GO terms cover diverse processes from energy metabolism (glucose response, ATP-linked electron transport, proton transport) to immune defense, coagulation, tissue remodeling, proteolysis, and transcription regulation, with no single clear theme tying them together. Therefore, there isn\u2019t a coherent functional label to assign with confidence.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":2},{"id":"GO:0042773","count":1},{"id":"GO:1902600","count":1},{"id":"GO:1903142","count":1},{"id":"GO:0070947","count":1}]},{"hash":"2069756253976877722","title":"Mitochondrial redox homeostasis and detoxification","description":"This cluster centers on oxidative stress defense and redox balance, highlighted by terms for removal of superoxide, cellular redox homeostasis, and detoxification of oxidants, as well as mitochondrial electron transport (NADH to ubiquinone) and the aerobic electron transport chain. Additional terms point to detox responses (herbicide, metals) and a tRNA modification process, suggesting a broader link to mitochondrial metabolism and cellular detoxification. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019430","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0002098","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0009635","count":1}]},{"hash":"1568136079688446126","title":"Translation and ribosome assembly","description":"The strongest signals are translation (GO:0006412) and ribosome assembly (GO:0042255), with a note of translation regulation (GO:0017148). Transcription-related terms and an antibiotic response term are present but appear as weaker signals; overall, the cluster centers on the protein synthesis machinery and its regulation, justifying the label.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006353","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0017148","count":1},{"id":"GO:0006351","count":1}]},{"hash":"1071779516724844193","title":"Neuronal synaptic plasticity and signaling","description":"This cluster is dominated by GO terms tied to neuronal communication and synaptic remodeling, including long-term potentiation/depression, receptor clustering, and long-term synaptic plasticity, with social behavior as a related function. While a few terms touch broader signaling pathways, the core pattern points to synaptic plasticity and neuronal signaling, justifying the label.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":2},{"id":"GO:1900273","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0060292","count":2},{"id":"GO:1901076","count":1}]},{"hash":"2230886003252648440","title":"Developmental morphogenesis and secretion","description":"Based on the top GO terms, two are directly about development: chitin-based cuticle development and body morphogenesis, suggesting a morphological role. The other terms (protein transport, endocytosis regulation, exocytosis, and cytokine production regulation) point to cellular remodeling and secretion processes that commonly accompany tissue morphogenesis. Taken together, the cluster appears to reflect developmental remodeling involving trafficking and secretion rather than a single narrow function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045806","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0050715","count":1},{"id":"GO:0045956","count":1},{"id":"GO:0040003","count":1}]},{"hash":"1817536011508088645","title":"Plasma Membrane Transporters for Sugars and Small Molecules","description":"GO terms indicate diverse transmembrane transport across the plasma membrane, spanning sugars (trehalose, fructose), urate, vitamins, sialic acid, phosphate ions, organic anions, xenobiotics, and related dietary/starvation responses, supporting a label of broadly acting membrane transporter proteins.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015771","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0015747","count":3},{"id":"GO:0042149","count":3},{"id":"GO:1990539","count":3}]},{"hash":"273837487517563131","title":"DNA replication and chromatin assembly during cell cycle","description":"The top GO terms reveal strong emphasis on nuclear genome maintenance activities\u2014leading strand elongation, CENP-A chromatin assembly, mitotic DNA replication checkpoint signaling, and transcription elongation regulation\u2014suggesting a function in DNA replication and chromatin organization during the cell cycle. Although some terms refer to ER-associated degradation and vesicle transport, the dominant signal is nuclear processes tied to replication and chromatin assembly.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006272","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0061641","count":2},{"id":"GO:0033314","count":2},{"id":"GO:0032968","count":2}]},{"hash":"1864034815827796807","title":"Proteasome Regulation","description":"This cluster is driven by the GO term negative regulation of proteasomal ubiquitin-dependent protein catabolic process, indicating a shared role in inhibiting proteasome-mediated protein degradation. The proteins appear to participate in a common regulatory theme of proteostasis control, making this a coherent, specific cluster.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":1}]},{"hash":"38707184690213651","title":"SnoRNA processing and transcription regulation","description":"The terms point to nuclear RNA processing activities (box C/D snoRNP assembly, snoRNA localization) alongside transcriptional regulation (DNA-templated termination/elongation, antitermination) and chromatin remodeling, suggesting a theme centered on RNA processing intersecting with transcription control. A DNA damage\u2013response term hints at broader genome integrity links, but the core signal is snoRNA processing and transcription regulation. Given the small cluster size and lack of observed edges, this label captures the primary shared function without overcommitting.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000492","count":1},{"id":"GO:0031063","count":1},{"id":"GO:0006338","count":1},{"id":"GO:0048254","count":1},{"id":"GO:0006353","count":1}]},{"hash":"1864154598231586003","title":"Blood cell differentiation regulation","description":"The top GO terms show repeated emphasis on regulation of erythrocyte and megakaryocyte differentiation (blood cell lineage), suggesting the cluster\u2019s core theme is hematopoietic differentiation control. While there are also broader developmental terms (cartilage morphogenesis, placenta development), the strongest signal is erythrocyte/megakaryocyte differentiation, justifying a label centered on blood cell differentiation regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045654","count":2},{"id":"GO:0010725","count":2},{"id":"GO:0045648","count":2},{"id":"GO:0003323","count":1},{"id":"GO:0007279","count":1}]},{"hash":"726759808722377595","title":"Developmental and stress-response signaling","description":"The cluster top terms center on developmental processes (thymus and placenta development), suggesting a developmental role, while several terms highlight cellular responses to ions and stimuli (cadmium, potassium, ATP, salt, sucrose), indicating a stress-response component that may accompany development. The mixed, but plausible, linkage supports a label around development with stress signaling.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048538","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0035865","count":2}]},{"hash":"253771054163271201","title":"Unknown","description":"The top terms include multiple nucleotide biosynthesis processes (UTP, GTP, CTP, and dGTP from dGDP) alongside diverse regulatory processes (negative regulation of phagocytosis, exocytosis, leukocyte differentiation) and keratinocyte differentiation, with no clear single function tying the trio together. Confidence is None because there isn\u2019t a cohesive, interpretable theme for this cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045618","count":1},{"id":"GO:0006228","count":1},{"id":"GO:0050765","count":1},{"id":"GO:0006187","count":1},{"id":"GO:0046777","count":1}]},{"hash":"2064022040756828524","title":"Neural development and synaptic signaling","description":"GO terms emphasize neural development and synaptic function\u2014neuron migration, NMDA receptor regulation, and chemical synaptic transmission\u2014with supporting roles for cell adhesion and trafficking; a single outlier term is erythrocyte differentiation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060319","count":1},{"id":"GO:0060391","count":1},{"id":"GO:1905602","count":1},{"id":"GO:1903077","count":1},{"id":"GO:0007268","count":1}]},{"hash":"2237069910014598331","title":"Chorion Eggshell Formation","description":"The GO terms point to development and, specifically, chorion-containing eggshell formation, suggesting these proteins participate in eggshell formation during multicellular development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":1},{"id":"GO:0007304","count":1}]},{"hash":"1558388742096369472","title":"Broad developmental differentiation","description":"The GO terms are dominated by diverse differentiation processes across multiple tissues and developmental contexts (e.g., glomus cell differentiation, endothelial differentiation, nerve development, somite formation, myoblast differentiation, and neuron differentiation). While some regulatory terms are present, there is no single cohesive pathway, suggesting a broad theme of developmental differentiation rather than a specific function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061103","count":3},{"id":"GO:0060842","count":3},{"id":"GO:0021558","count":3},{"id":"GO:0045663","count":3},{"id":"GO:0048658","count":3}]},{"hash":"452222906144005046","title":"Unknown","description":"There are no GO terms listed for this cluster, so there is no evident common function linking the three proteins. The small network (2 edges, no triangles) provides insufficient data to infer a meaningful biological label.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"1160072470536023598","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0075522","count":1},{"id":"GO:0006469","count":1},{"id":"GO:0036494","count":1}]},{"hash":"2197598782788419615","title":"ER-Golgi trafficking and calcium regulation","description":"Based on GO terms, the cluster centers on ER-to-Golgi vesicle transport, localization to ER exit sites, and general intracellular transport, with regulation of ER calcium concentration and related calcium signaling, consistent with components of the secretory pathway and calcium homeostasis. Some glycosylation terms support secretory processing, while an osteoblast differentiation term appears as a minor outlier. Overall, the core theme is secretory pathway transport coupled to calcium regulation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015693","count":1},{"id":"GO:0018279","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0032471","count":1},{"id":"GO:0006888","count":1}]},{"hash":"1534221618416647364","title":"DNA Damage Checkpoint and Repair Regulation","description":"These proteins cluster around DNA damage response and repair, with terms for negative regulation of DNA damage checkpoint, meiotic double-strand break formation, and regulation of double-strand break repair via nonhomologous end joining. While a few other terms touch on translation control or neuronal morphogenesis, the strongest signal is DNA damage signaling and repair coordinated with cell division, supporting this as the core theme of the cluster.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000002","count":3},{"id":"GO:0050774","count":3},{"id":"GO:0010780","count":3},{"id":"GO:0042220","count":3},{"id":"GO:1901901","count":3}]},{"hash":"632854703229460423","title":"DNA Damage Response and Meiotic Recombination Regulation","description":"The top GO terms cluster around DNA damage checkpoint regulation, meiotic double-strand break formation, and repair via nonhomologous end joining, pointing to a shared theme of genome maintenance during replication and meiosis. Additional terms related to stress-responsive translational control and cytokinesis localization suggest broader cellular stress and division coordination, but the core signal centers on DNA repair and meiotic recombination processes.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000002","count":3},{"id":"GO:0050774","count":3},{"id":"GO:0010780","count":3},{"id":"GO:0042220","count":3},{"id":"GO:1901901","count":3}]},{"hash":"1909670923699747953","title":"Nuclear import and protein oligomerization","description":"These proteins show strong signals for nuclear transport (tRNA export from nucleus, import into nucleus, NLS-bearing protein import, mitotic nuclear membrane disassembly) alongside multiple terms for protein complex formation (homooligomerization, heterotrimerization, heterotetramerization). This suggests a theme of coordinating nuclear trafficking with assembly of protein complexes, with other terms like virus transport and Ras signaling likely secondary. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006409","count":3},{"id":"GO:0010827","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0042306","count":3},{"id":"GO:0075733","count":3}]},{"hash":"1777138947352118666","title":"Nucleolar rDNA Chromatin Regulation","description":"The GO terms center on nucleolar rDNA repeats, pericentric heterochromatin formation, and regulation of rDNA heterochromatin, as well as related protein stability and chaperone-mediated assembly, suggesting a theme of nucleolar chromatin maintenance and chromatin-associated regulation. Some terms are obsolete or peripheral (e.g., plant defense), but the core signal is chromatin/nucleolar regulation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010978","count":2},{"id":"GO:0009861","count":2},{"id":"GO:0061587","count":2},{"id":"GO:0061188","count":2},{"id":"GO:0090035","count":2}]},{"hash":"1662993332179136638","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0070843","count":2},{"id":"GO:1901621","count":2}]},{"hash":"1225667337275987971","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002532","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0006032","count":1},{"id":"GO:0090197","count":1},{"id":"GO:0071031","count":1}]},{"hash":"901978680063907246","title":"Fungal sterol and sphingolipid biosynthesis","description":"The dominant GO terms point to lipid and sterol metabolism common in fungi: unsaturated fatty acid biosynthesis, regulation of ergosterol biosynthetic process, and sphingolipid metabolism (mannosyl-inositol phosphorylceramide). While some terms seem unrelated (e.g., CNS or sebaceous gland differentiation), the core signals converge on fungal lipid pathways, especially ergosterol and sphingolipid production. This suggests a cluster centered on fungal sterol and sphingolipid biosynthesis. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0032443","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0001949","count":3}]},{"hash":"440896793087913652","title":"Wnt Signaling Regulation and APC-Dependent Proteolysis","description":"The cluster shows strong signals for regulating canonical Wnt signaling (both positive and negative) and planar cell polarity, along with APC-dependent catabolic processes and proteasomal/ubiquitin-associated protein turnover. These themes point to a cohesive link between Wnt pathway control and cell-cycle\u2013related proteolysis, with other terms like viral process or metal response being less central. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090090","count":2},{"id":"GO:0038061","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0051436","count":2}]},{"hash":"891752965392556404","title":"Hematopoietic and vascular differentiation","description":"The top GO terms center on cell fate, differentiation, and lineage specification in hematopoietic and vascular contexts (hematopoietic stem cell proliferation, myeloid dendritic cell differentiation, blood vessel morphogenesis, epithelial/mammary gland differentiation, epithelial cell proliferation, and general cell fate determination), indicating a developmental differentiation program spanning blood, vessel, and epithelial lineages.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035155","count":1},{"id":"GO:0045653","count":1},{"id":"GO:0071425","count":1},{"id":"GO:1902262","count":1},{"id":"GO:0050673","count":1}]},{"hash":"2193139332813556115","title":"Retinoic acid signaling and lipid metabolism","description":"The GO terms cluster around retinoic acid signaling regulation (GO:0048385) and vitamin A metabolism (GO:0006776), with several lipid-related processes such as phosphatidylcholine biosynthesis, cholesterol homeostasis, fatty acid oxidation regulation, and prostaglandin biosynthesis. Developmental terms like eye development and female genitalia morphogenesis are also linked to retinoic acid pathways, supporting a theme where RA signaling intersects lipid metabolism and development. The small connectedness (one edge, no triangles) suggests a loose module, so the label is best described with Medium confidence.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0048385","count":2},{"id":"GO:0006656","count":2},{"id":"GO:0001654","count":2},{"id":"GO:2000778","count":2}]},{"hash":"1602847033011379897","title":"Plant carbohydrate catabolism and storage","description":"These proteins are annotated with multiple plant sugar catabolic processes (raffinose, sucrose, inulin) and carbohydrate storage, suggesting a shared role in sugar metabolism. Additional terms related to gibberellin and karrikin responses imply hormone-regulated growth signaling accompanies this metabolic theme. Overall, the cluster seems to reflect plant carbohydrate metabolism with associated hormone signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034484","count":1},{"id":"GO:0080167","count":1},{"id":"GO:0005987","count":1},{"id":"GO:1902927","count":1},{"id":"GO:0071370","count":1}]},{"hash":"1433010909442956300","title":"Cell cycle and apoptotic pathway regulation","description":"The top GO terms point to regulation of the cell cycle and suppression of cell death (negative regulation of apoptosis, necroptotic process regulation) along with regulatory processes like transcription and ubiquitination. There is also an immune signaling element (regulation of TLR signaling) and a developmental hint (embryonic neurocranium morphogenesis), but the recurrent theme centers on controlling cell fate and survival via ubiquitin-mediated regulation. Given the limited number of proteins and mixed functions, this label captures the core shared function without overstating specificity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":2},{"id":"GO:0060544","count":1},{"id":"GO:0043066","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0034121","count":1}]},{"hash":"547362092880748800","title":"Endosomal-Lysosomal Trafficking and Neuronal Development","description":"The proteins in this cluster link lysosome localization, endosome-to-melanosome transport, and receptor internalization, plus developmental terms for microglia and photoreceptor/neural differentiation, suggesting a theme of vesicle trafficking with neural-immune development roles.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901223","count":1},{"id":"GO:0061462","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0014005","count":1},{"id":"GO:0035646","count":1}]},{"hash":"594542806040283681","title":"Unknown","description":"There are three proteins in the cluster, but no GO terms are listed to indicate a shared function or process, so a meaningful label cannot be inferred.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"2255834680606265790","title":"Unknown","description":"The top GO terms span very different processes (transport of amino acids and sugars, glycosylation, lens development, grooming behavior, and nitrogen starvation responses) with no clear shared function among the three proteins. This heterogeneity suggests there is no coherent biological theme to label the cluster with a specific name.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015811","count":1},{"id":"GO:0002088","count":1},{"id":"GO:0034488","count":1},{"id":"GO:0080144","count":1},{"id":"GO:0060905","count":1}]},{"hash":"763955548613821132","title":"Proteoglycan Biosynthesis and ECM Metabolism","description":"The top GO terms are dominated by proteoglycan metabolic processes, especially heparan sulfate and dermatan sulfate proteoglycans, indicating a core role in proteoglycan biosynthesis and extracellular matrix (ECM) components. Related development terms (chondrocyte development, ureteric bud formation) further support a ECM/territory of tissue patterning context. Although some terms are less related, the shared theme centers on proteoglycan synthesis and ECM biology.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042595","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0030202","count":1},{"id":"GO:0060676","count":1},{"id":"GO:0015768","count":1}]}]