{"hash":"993421152652538800","title":"Amino acid and monoamine metabolism","description":"This cluster is dominated by amino acid and monoamine biosynthesis/catabolism signals (dopamine, histamine, taurine, glutamate) and related alkaloid metabolic processes, with the TCA cycle suggesting underlying energy support. While there are a few outliers (e.g., Leydig cell differentiation), the core pattern points to amino acid/amine metabolism and neurotransmitter biosynthesis as the main theme.","confidence":"Medium","size":14,"edges":82,"triangles":265,"max_degree":13,"top_function":null,"members":[{"accession":"XP_010596284.1","go_terms":["GO:0006085","GO:0019679","GO:0019629","GO:0006099"]},{"accession":"XP_010595131.1","go_terms":["GO:0046677","GO:0009252","GO:0070592","GO:0045227","GO:0007049","GO:0019853","GO:0009823","GO:0009820","GO:0071555","GO:0051301","GO:0008360","GO:0015945","GO:0070485","GO:0035884","GO:0019516","GO:1903457","GO:0008611"]},{"accession":"XP_064149281.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0048082","GO:0042136","GO:0048085","GO:0007615","GO:0035690","GO:0009449","GO:0051454","GO:0010259","GO:0033327","GO:0019722","GO:0071312","GO:0046684","GO:0010761","GO:0006665","GO:0015842","GO:0007623","GO:0033076","GO:0006585","GO:0006587","GO:0042412","GO:0001553","GO:2001120","GO:0071363","GO:0052314","GO:0043052","GO:0001694","GO:0006538"]},{"accession":"XP_003420186.1","go_terms":["GO:0048082","GO:0042136","GO:0048085","GO:0007615","GO:0035690","GO:0009449","GO:0051454","GO:0010259","GO:0033327","GO:0019722","GO:0071312","GO:0046684","GO:0010761","GO:0006665","GO:0015842","GO:0007623","GO:0033076","GO:0006585","GO:0006587","GO:0042412","GO:0001553","GO:2001120","GO:0071363","GO:0052314","GO:0043052","GO:0001694","GO:0006538"]},{"accession":"XP_010599385.3","go_terms":["GO:0072756","GO:0009228","GO:0072747","GO:0046166","GO:0061732","GO:0006098","GO:0006096","GO:0055114","GO:0052865","GO:0005999","GO:0040008","GO:0010510","GO:0006006","GO:0016114","GO:0009052","GO:0019253","GO:0061034","GO:0006099","GO:0021695","GO:0046487","GO:0009083","GO:0021860","GO:0022028"]},{"accession":"XP_064126315.1","go_terms":["GO:0030851","GO:0042135","GO:0034720","GO:0051412","GO:0046653","GO:0035563","GO:0010044","GO:0001701","GO:0043046","GO:0007369","GO:0009106","GO:0098869","GO:0010725","GO:0060992","GO:2000179","GO:1990138","GO:0046886","GO:0045454","GO:0014063","GO:0045793","GO:0007568","GO:0071320","GO:0045654","GO:0009061","GO:0006121","GO:0006120","GO:0042391","GO:0051068","GO:0042493","GO:0009435","GO:0006099","GO:0021983","GO:0032496","GO:0048240","GO:0021987","GO:0042420","GO:0000380","GO:0045648","GO:0019563","GO:0006096","GO:0016575","GO:2000648","GO:0009228","GO:0045471","GO:0046098","GO:0051572","GO:0051573","GO:0002098","GO:0010269","GO:0042551","GO:0006103","GO:0045964","GO:0006105"]},{"accession":"XP_064130457.1","go_terms":["GO:0072756","GO:0009228","GO:0072747","GO:0046166","GO:0061732","GO:0006098","GO:0006096","GO:0055114","GO:0052865","GO:0005999","GO:0040008","GO:0010510","GO:0006006","GO:0016114","GO:0009052","GO:0019253","GO:0061034","GO:0006099","GO:0021695","GO:0046487","GO:0009083","GO:0021860","GO:0022028"]},{"accession":"XP_064135786.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0050689","GO:0071360","GO:0045087","GO:0008277","GO:0051301","GO:0045454","GO:0000492","GO:0001041","GO:0070206","GO:0008653","GO:0007346","GO:0071908","GO:0071492","GO:0045070","GO:0071909","GO:0003283","GO:0051661","GO:0072189","GO:0046890","GO:0048496","GO:0050714","GO:0051348","GO:0006986","GO:0000278","GO:0045842","GO:0034454","GO:0021756","GO:0046548","GO:0060613","GO:1903546","GO:0038108","GO:0090526","GO:0003085","GO:0060296","GO:0061087","GO:0035845","GO:1903646","GO:1905515","GO:0070389","GO:1902855","GO:0070979","GO:0042787","GO:0007091","GO:0030433","GO:0006478","GO:0016570","GO:2001162","GO:0035457","GO:1903071","GO:0031145","GO:0036494","GO:0051607","GO:1902391","GO:2000324","GO:0015979","GO:0000413","GO:0009736","GO:0035955","GO:0016576","GO:1902325","GO:1903070","GO:0010288","GO:0070301","GO:0051291","GO:2000531","GO:0071276","GO:0043278","GO:1901215","GO:0031400","GO:0009938"]},{"accession":"XP_064135795.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0050689","GO:0071360","GO:0045087","GO:0008277","GO:0051301","GO:0045454","GO:0000492","GO:0001041","GO:0070206","GO:0008653","GO:0007346","GO:0071908","GO:0071492","GO:0045070","GO:0071909","GO:0003283","GO:0051661","GO:0072189","GO:0046890","GO:0048496","GO:0050714","GO:0051348","GO:0006986","GO:0000278","GO:0045842","GO:0034454","GO:0021756","GO:0046548","GO:0060613","GO:1903546","GO:0038108","GO:0090526","GO:0003085","GO:0060296","GO:0061087","GO:0035845","GO:1903646","GO:1905515","GO:0070389","GO:1902855","GO:0070979","GO:0042787","GO:0007091","GO:0030433","GO:0006478","GO:0016570","GO:2001162","GO:0035457","GO:1903071","GO:0031145","GO:0036494","GO:0051607","GO:1902391","GO:2000324","GO:0015979","GO:0000413","GO:0009736","GO:0035955","GO:0016576","GO:1902325","GO:1903070","GO:0010288","GO:0070301","GO:0051291","GO:2000531","GO:0071276","GO:0043278","GO:1901215","GO:0031400","GO:0009938"]},{"accession":"XP_064140994.1","go_terms":["GO:0048082","GO:0042136","GO:0048085","GO:0007615","GO:0035690","GO:0009449","GO:0051454","GO:0010259","GO:0033327","GO:0019722","GO:0071312","GO:0046684","GO:0010761","GO:0006665","GO:0015842","GO:0007623","GO:0033076","GO:0006585","GO:0006587","GO:0042412","GO:0001553","GO:2001120","GO:0071363","GO:0052314","GO:0043052","GO:0001694","GO:0006538"]},{"accession":"XP_003406143.1","go_terms":["GO:0008585","GO:0006099","GO:0006097","GO:0019878","GO:1903976","GO:0006749","GO:0071071","GO:0006740","GO:0009098","GO:1904465","GO:0060253","GO:0006979","GO:0006537","GO:0006741","GO:0006103","GO:0006102","GO:0060696","GO:0048545"]},{"accession":"XP_003415357.1","go_terms":["GO:0006450","GO:0046944","GO:0002949"]},{"accession":"XP_003418552.1","go_terms":["GO:0072756","GO:0009228","GO:0072747","GO:0046166","GO:0061732","GO:0006098","GO:0006096","GO:0055114","GO:0052865","GO:0005999","GO:0040008","GO:0010510","GO:0006006","GO:0016114","GO:0009052","GO:0019253","GO:0061034","GO:0006099","GO:0021695","GO:0046487","GO:0009083","GO:0021860","GO:0022028"]},{"accession":"XP_010593841.1","go_terms":["GO:0048082","GO:0042136","GO:0048085","GO:0007615","GO:0035690","GO:0009449","GO:0051454","GO:0010259","GO:0033327","GO:0019722","GO:0071312","GO:0046684","GO:0010761","GO:0006665","GO:0015842","GO:0007623","GO:0033076","GO:0006585","GO:0006587","GO:0042412","GO:0001553","GO:2001120","GO:0071363","GO:0052314","GO:0043052","GO:0001694","GO:0006538"]}],"graph":[["XP_010593841.1","XP_064130457.1",0.912],["XP_010593841.1","XP_064126315.1",0.965],["XP_010593841.1","XP_064149281.1",0.524],["XP_010593841.1","XP_064140994.1",0.633],["XP_010593841.1","XP_064135786.1",0.932],["XP_010593841.1","XP_064135795.1",0.909],["XP_010593841.1","XP_003406143.1",0.885],["XP_010593841.1","XP_003415357.1",0.856],["XP_010593841.1","XP_003418552.1",0.93],["XP_010593841.1","XP_003420186.1",0.92],["XP_010593841.1","XP_010595131.1",0.884],["XP_010593841.1","XP_010596284.1",0.893],["XP_010593841.1","XP_010599385.3",0.889],["XP_064149281.1","XP_003420186.1",0.728],["XP_064149281.1","XP_010595131.1",0.952],["XP_064149281.1","XP_010596284.1",0.863],["XP_064149281.1","XP_010599385.3",0.953],["XP_064149281.1","XP_064126315.1",0.9],["XP_064149281.1","XP_064130457.1",0.976],["XP_064149281.1","XP_064135786.1",0.969],["XP_064149281.1","XP_064135795.1",0.951],["XP_064149281.1","XP_003406143.1",0.95],["XP_064149281.1","XP_003415357.1",0.893],["XP_064149281.1","XP_003418552.1",0.924],["XP_064126315.1","XP_010595131.1",0.595],["XP_064126315.1","XP_010596284.1",0.641],["XP_064126315.1","XP_010599385.3",0.73],["XP_064126315.1","XP_064130457.1",0.776],["XP_064126315.1","XP_064140994.1",0.945],["XP_064126315.1","XP_064135786.1",0.981],["XP_064126315.1","XP_064135795.1",0.974],["XP_064126315.1","XP_003406143.1",0.854],["XP_064126315.1","XP_003418552.1",0.859],["XP_064126315.1","XP_003420186.1",0.716],["XP_003420186.1","XP_064135786.1",0.842],["XP_003420186.1","XP_064135795.1",0.78],["XP_003420186.1","XP_064140994.1",0.967],["XP_003420186.1","XP_003406143.1",0.907],["XP_003420186.1","XP_003415357.1",0.573],["XP_003420186.1","XP_003418552.1",0.965],["XP_003420186.1","XP_010595131.1",0.854],["XP_003420186.1","XP_010596284.1",0.717],["XP_003420186.1","XP_010599385.3",0.594],["XP_003420186.1","XP_064130457.1",0.781],["XP_003418552.1","XP_003415357.1",0.924],["XP_003418552.1","XP_010595131.1",0.669],["XP_003418552.1","XP_010596284.1",0.814],["XP_003418552.1","XP_010599385.3",0.751],["XP_003418552.1","XP_064135786.1",0.877],["XP_003418552.1","XP_064135795.1",0.968],["XP_003418552.1","XP_064140994.1",0.947],["XP_003406143.1","XP_003415357.1",0.887],["XP_003406143.1","XP_010599385.3",0.778],["XP_003406143.1","XP_064130457.1",0.599],["XP_003406143.1","XP_064140994.1",0.878],["XP_003406143.1","XP_064135786.1",0.958],["XP_003406143.1","XP_064135795.1",0.975],["XP_064130457.1","XP_010595131.1",0.757],["XP_064130457.1","XP_010596284.1",0.832],["XP_064130457.1","XP_010599385.3",0.753],["XP_064130457.1","XP_064140994.1",0.943],["XP_064130457.1","XP_064135786.1",0.628],["XP_064130457.1","XP_064135795.1",0.796],["XP_064130457.1","XP_003415357.1",0.921],["XP_010596284.1","XP_064140994.1",0.962],["XP_010596284.1","XP_064135786.1",0.536],["XP_010596284.1","XP_010595131.1",0.722],["XP_010596284.1","XP_010599385.3",0.668],["XP_064135795.1","XP_010595131.1",0.9],["XP_064135795.1","XP_010599385.3",0.686],["XP_064135795.1","XP_064140994.1",0.987],["XP_064135795.1","XP_003415357.1",0.976],["XP_064140994.1","XP_010595131.1",0.933],["XP_064140994.1","XP_010599385.3",0.766],["XP_064140994.1","XP_064135786.1",0.981],["XP_064140994.1","XP_003415357.1",0.983],["XP_003415357.1","XP_010595131.1",0.959],["XP_003415357.1","XP_010599385.3",0.865],["XP_003415357.1","XP_064135786.1",0.873],["XP_010599385.3","XP_064135786.1",0.622],["XP_010599385.3","XP_010595131.1",0.793],["XP_010595131.1","XP_064135786.1",0.691]],"all_go_terms":{"GO:0006099":6,"GO:0006085":1,"GO:0019629":1,"GO:0019679":1,"GO:0009823":1,"GO:0051301":3,"GO:0008360":1,"GO:0008611":1,"GO:0015945":1,"GO:0019853":1,"GO:0035884":1,"GO:0070485":1,"GO:0045227":1,"GO:0070592":1,"GO:0009820":1,"GO:0007049":1,"GO:0046677":1,"GO:1903457":1,"GO:0009252":1,"GO:0019516":1,"GO:0071555":1,"GO:0043420":1,"GO:0033327":4,"GO:0071312":4,"GO:0051454":4,"GO:0042412":4,"GO:0001694":4,"GO:0070903":1,"GO:0010259":4,"GO:0006538":4,"GO:0034516":1,"GO:0046724":1,"GO:0019265":1,"GO:0033076":4,"GO:0019442":1,"GO:0006585":4,"GO:0006564":1,"GO:0035690":4,"GO:2001120":4,"GO:0009436":1,"GO:0052314":4,"GO:0007615":4,"GO:0043052":4,"GO:0006587":4,"GO:0006546":1,"GO:0042136":4,"GO:0051591":1,"GO:0044571":1,"GO:0046684":4,"GO:0019700":1,"GO:0001553":4,"GO:0019805":1,"GO:0071363":4,"GO:0042853":1,"GO:0018283":1,"GO:0010761":4,"GO:0006665":4,"GO:0015842":4,"GO:0097053":1,"GO:0019448":1,"GO:0007623":4,"GO:0034354":1,"GO:0051384":1,"GO:0007219":1,"GO:0048085":4,"GO:0048082":4,"GO:0019722":4,"GO:0009449":4,"GO:0042866":1,"GO:0008615":1,"GO:0006006":3,"GO:0009052":3,"GO:0021695":3,"GO:0009083":3,"GO:0052865":3,"GO:0061034":3,"GO:0072747":3,"GO:0046487":3,"GO:0016114":3,"GO:0046166":3,"GO:0006096":4,"GO:0005999":3,"GO:0006098":3,"GO:0019253":3,"GO:0009228":4,"GO:0021860":3,"GO:0022028":3,"GO:0010510":3,"GO:0061732":3,"GO:0055114":3,"GO:0072756":3,"GO:0040008":3,"GO:0000380":1,"GO:0014063":1,"GO:0010269":1,"GO:0043046":1,"GO:0034720":1,"GO:2000179":1,"GO:0006103":2,"GO:0045964":1,"GO:0010725":1,"GO:0021983":1,"GO:0046098":1,"GO:0042391":1,"GO:0071320":1,"GO:0051412":1,"GO:0007568":1,"GO:0006120":1,"GO:0060992":1,"GO:0051068":1,"GO:0042420":1,"GO:0045793":1,"GO:0045654":1,"GO:0042135":1,"GO:2000648":1,"GO:0032496":1,"GO:0030851":1,"GO:0035563":1,"GO:0042493":1,"GO:0051572":1,"GO:0007369":1,"GO:0009435":1,"GO:0009061":1,"GO:0045471":1,"GO:0046886":1,"GO:0048240":1,"GO:0016575":1,"GO:0098869":1,"GO:0001701":1,"GO:0045648":1,"GO:0051573":1,"GO:0046653":1,"GO:0045454":3,"GO:0006105":1,"GO:0042551":1,"GO:0019563":1,"GO:0002098":1,"GO:0009106":1,"GO:1990138":1,"GO:0006121":1,"GO:0021987":1,"GO:0010044":1,"GO:0003283":2,"GO:0046661":2,"GO:1902391":2,"GO:0046890":2,"GO:1903546":2,"GO:0035845":2,"GO:0015979":2,"GO:0045087":2,"GO:0001041":2,"GO:2000531":2,"GO:0030433":2,"GO:0071357":2,"GO:0036494":2,"GO:0051348":2,"GO:0050689":2,"GO:0007346":2,"GO:0003085":2,"GO:0030850":2,"GO:0000413":2,"GO:1901215":2,"GO:0050714":2,"GO:0009736":2,"GO:0038108":2,"GO:1903070":2,"GO:0006478":2,"GO:0061087":2,"GO:0070301":2,"GO:0031400":2,"GO:0071908":2,"GO:0071909":2,"GO:0045842":2,"GO:0072189":2,"GO:0051291":2,"GO:2000324":2,"GO:0071492":2,"GO:0006986":2,"GO:0060613":2,"GO:0051607":2,"GO:0016576":2,"GO:0010288":2,"GO:0070979":2,"GO:0045070":2,"GO:0000278":2,"GO:0035955":2,"GO:1905515":2,"GO:1902325":2,"GO:0008277":2,"GO:0042787":2,"GO:0006463":2,"GO:0035457":2,"GO:1903071":2,"GO:0043278":2,"GO:0034454":2,"GO:0071276":2,"GO:0070389":2,"GO:0051661":2,"GO:0021756":2,"GO:1903646":2,"GO:1902855":2,"GO:0007091":2,"GO:0090526":2,"GO:0031145":2,"GO:0071360":2,"GO:0070206":2,"GO:0000492":2,"GO:0046548":2,"GO:0008653":2,"GO:0016570":2,"GO:0048496":2,"GO:0060296":2,"GO:2001162":2,"GO:0009938":2,"GO:0006097":1,"GO:0008585":1,"GO:0009098":1,"GO:0019878":1,"GO:0071071":1,"GO:0006979":1,"GO:0060253":1,"GO:0006740":1,"GO:1904465":1,"GO:0006102":1,"GO:0060696":1,"GO:0048545":1,"GO:0006537":1,"GO:1903976":1,"GO:0006749":1,"GO:0006741":1,"GO:0046944":1,"GO:0006450":1,"GO:0002949":1},"recipe_readded":[]}