{"hash":"391717654608753066","title":"ER protein folding and quality control","description":"The top terms cluster around endoplasmic reticulum maturation and quality-control processes: protein folding in the ER, misfolded protein transport, ER-associated degradation (ERAD), and regulation of protein export from the nucleus. Additionally, ER stress-related translation initiation is represented, consistent with a coordinated ER stress response that upregulates protein folding capacity and quality-control pathways. Some terms (tRNA import into nucleus, DNA replication) appear as sporadic annotations and may reflect incidental associations rather than core function of the cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_010591097.2","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_003414060.1","go_terms":["GO:0000381","GO:0008380","GO:0016575","GO:0006351","GO:0048025","GO:1903507","GO:0006397"]},{"accession":"XP_064123617.1","go_terms":["GO:0007165"]},{"accession":"XP_064131295.1","go_terms":["GO:0006423","GO:0010125","GO:0006431","GO:0006429"]}],"graph":[],"all_go_terms":{"GO:0035719":1,"GO:1900035":1,"GO:0070843":1,"GO:0034975":1,"GO:0006260":1,"GO:0046825":1,"GO:0030433":1,"GO:0051259":1,"GO:0036494":1,"GO:0097428":1,"GO:0032781":1,"GO:0090084":1,"GO:0006458":1,"GO:0001707":1,"GO:0006986":1,"GO:0006452":1,"GO:0009408":1,"GO:0071630":1,"GO:0070389":1,"GO:0045454":1,"GO:0071374":1,"GO:0031204":1,"GO:0006469":1,"GO:0006626":1,"GO:1901621":1,"GO:0048025":1,"GO:0006351":1,"GO:0008380":1,"GO:0000381":1,"GO:1903507":1,"GO:0006397":1,"GO:0016575":1,"GO:0007165":1,"GO:0006431":1,"GO:0006429":1,"GO:0006423":1,"GO:0010125":1},"recipe_readded":["XP_023407212.1","XP_023395618.2","XP_003409178.1","XP_064134051.1","XP_064145445.1","XP_003405897.1","XP_003418217.1","XP_003421243.2","XP_003418124.1","XP_003420204.3","XP_064138597.1","XP_023406245.1","XP_064151165.1","XP_003410342.1","XP_003417566.2","XP_003408078.1","XP_064136171.1","XP_003419149.1","XP_064133200.1","XP_010595505.3"]}