{"hash":"230627411384550277","title":"Keratinization and Epidermal Remodeling","description":"This cluster is driven by keratinization (GO:0031424) with the strongest signal, pointing to epidermal differentiation and skin-related processes. Additional signals, such as epithelial-to-mesenchymal transition, sprouting angiogenesis and endothelial proliferation, as well as innate immune response participation, suggest a broader context of tissue remodeling and wound healing where keratinocytes interact with vasculature and immune components. Some lipid metabolism and circadian terms are present but less central. Overall, the dominant theme is keratinocyte differentiation with remodeling aspects.","confidence":"Medium","size":13,"edges":32,"triangles":40,"max_degree":10,"top_function":null,"members":[{"accession":"XP_023397337.1","go_terms":[]},{"accession":"XP_023403947.2","go_terms":["GO:0031424"]},{"accession":"XP_023403948.2","go_terms":["GO:0031424"]},{"accession":"XP_023403980.1","go_terms":[]},{"accession":"XP_064145007.1","go_terms":[]},{"accession":"XP_003410358.1","go_terms":["GO:0031424"]},{"accession":"XP_023403949.1","go_terms":["GO:0031424"]},{"accession":"XP_023403951.1","go_terms":["GO:0031424"]},{"accession":"XP_023403952.1","go_terms":["GO:0031424"]},{"accession":"XP_003416716.1","go_terms":["GO:1905053"]},{"accession":"XP_023411875.1","go_terms":["GO:1905053"]},{"accession":"XP_064126701.1","go_terms":["GO:0007519","GO:0036268","GO:0072156","GO:0042748","GO:1900242","GO:0042787","GO:0035853","GO:0035914","GO:0031397","GO:2000312","GO:0050853","GO:0048741","GO:0045214","GO:0002467","GO:0007399","GO:1990390","GO:0070294","GO:0060693","GO:0006898","GO:2000329","GO:0021510","GO:1905590","GO:0018277","GO:0043542","GO:0002438","GO:0031638","GO:0032332","GO:0010744","GO:0002040","GO:2000483","GO:0070207","GO:1904274","GO:2001046","GO:0045087","GO:0018057","GO:0001771","GO:0043277","GO:0006958","GO:0061053","GO:1900017","GO:0034381","GO:0001837","GO:0010886","GO:0030199","GO:0042953","GO:0001935"]},{"accession":"XP_003413033.1","go_terms":["GO:0101030","GO:0008616"]}],"graph":[["XP_023411875.1","XP_023403951.1",0.502],["XP_023411875.1","XP_023403980.1",0.826],["XP_023403949.1","XP_023403947.2",0.881],["XP_023403949.1","XP_023403948.2",0.715],["XP_023403949.1","XP_023403951.1",0.944],["XP_023403949.1","XP_023403952.1",0.931],["XP_023403949.1","XP_023403980.1",0.841],["XP_023403949.1","XP_003410358.1",0.862],["XP_003416716.1","XP_023403980.1",0.67],["XP_023403980.1","XP_023403947.2",0.951],["XP_023403980.1","XP_023403948.2",0.92],["XP_023403980.1","XP_023403951.1",0.927],["XP_023403980.1","XP_023403952.1",0.926],["XP_023403980.1","XP_064145007.1",0.895],["XP_023403980.1","XP_003410358.1",0.906],["XP_023403980.1","XP_003413033.1",0.769],["XP_023403948.2","XP_064126701.1",0.804],["XP_023403948.2","XP_023403947.2",0.939],["XP_023403948.2","XP_023403951.1",0.934],["XP_023403948.2","XP_023403952.1",0.931],["XP_023403948.2","XP_003410358.1",0.84],["XP_003413033.1","XP_064145007.1",0.738],["XP_003410358.1","XP_023403947.2",0.897],["XP_003410358.1","XP_023403951.1",0.913],["XP_003410358.1","XP_023403952.1",0.662],["XP_023403951.1","XP_023403947.2",0.662],["XP_023403951.1","XP_023403952.1",0.853],["XP_023403951.1","XP_064145007.1",0.531],["XP_064145007.1","XP_023403952.1",0.738],["XP_064145007.1","XP_064126701.1",0.646],["XP_064126701.1","XP_023397337.1",0.509],["XP_023403947.2","XP_023403952.1",0.966]],"all_go_terms":{"GO:0031424":6,"GO:1905053":2,"GO:0021510":1,"GO:0001935":1,"GO:0002040":1,"GO:0001837":1,"GO:0010886":1,"GO:0034381":1,"GO:0045087":1,"GO:0042748":1,"GO:0035914":1,"GO:0061053":1,"GO:0050853":1,"GO:1904274":1,"GO:0031638":1,"GO:0031397":1,"GO:1905590":1,"GO:0036268":1,"GO:0032332":1,"GO:0060693":1,"GO:0072156":1,"GO:2000312":1,"GO:0007399":1,"GO:0018057":1,"GO:0001771":1,"GO:1990390":1,"GO:0048741":1,"GO:2001046":1,"GO:0006898":1,"GO:0070294":1,"GO:0042953":1,"GO:0043277":1,"GO:0042787":1,"GO:0035853":1,"GO:1900017":1,"GO:0043542":1,"GO:0030199":1,"GO:0006958":1,"GO:1900242":1,"GO:0018277":1,"GO:0010744":1,"GO:0002467":1,"GO:2000483":1,"GO:2000329":1,"GO:0045214":1,"GO:0007519":1,"GO:0070207":1,"GO:0002438":1,"GO:0008616":1,"GO:0101030":1},"recipe_readded":[]}