{"hash":"2161878686820946233","title":"Nuclear mRNA Splicing and Processing","description":"These proteins cluster around nuclear mRNA maturation: spliceosome-mediated splicing (including alternative splicing), mRNA export, poly(A) tail regulation, and overall mRNA modification/stability, with additional ties to translation reinitiation. The dominant theme is splicing and processing of nascent transcripts rather than cytosolic translation, suggesting a spliceosome/mRNA maturation module.","confidence":"High","size":22,"edges":184,"triangles":894,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","members":[{"accession":"XP_064148989.1","go_terms":["GO:0001302","GO:0071291","GO:0010447","GO:0003069","GO:0048773","GO:0019430","GO:0001320","GO:0055114"]},{"accession":"XP_003414171.1","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0071230","GO:0046011","GO:1900365","GO:0071456","GO:1900248","GO:0008069","GO:0061158","GO:0060213","GO:0007310","GO:0032869","GO:0002931","GO:0045451"]},{"accession":"XP_003417302.1","go_terms":["GO:0016126","GO:0032435","GO:0048633","GO:0032288","GO:0046716","GO:1902902","GO:0035038","GO:0098755","GO:0035335","GO:0043087","GO:0071442","GO:0007343","GO:0051262","GO:0046856","GO:0046855","GO:0048666","GO:0035039","GO:0071391","GO:0030259","GO:0045815","GO:0045109","GO:0031642","GO:0002233","GO:0032120"]},{"accession":"XP_064151633.1","go_terms":["GO:0000381","GO:0050885","GO:0030520","GO:0021942","GO:0010724","GO:0048739","GO:0048813","GO:2001014","GO:0008380","GO:0006397","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_003404525.4","go_terms":["GO:0030324","GO:2000329","GO:0021510","GO:0060021","GO:1905590","GO:0001837","GO:0018277","GO:0043542","GO:0032332","GO:0048514","GO:0046688","GO:0002040","GO:2001046","GO:0018057","GO:0048251","GO:0061053","GO:0001935","GO:0030199","GO:0035904"]},{"accession":"XP_064127119.1","go_terms":["GO:0007638","GO:0045071","GO:0007283","GO:0006955","GO:0007286","GO:0000398"]},{"accession":"XP_010588620.2","go_terms":["GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378","GO:0070940","GO:0051209","GO:0051533","GO:0042769","GO:0006369","GO:0006379","GO:0010526"]},{"accession":"XP_010595211.1","go_terms":["GO:0000381","GO:0050885","GO:0030520","GO:0021942","GO:0010724","GO:0048739","GO:0048813","GO:2001014","GO:0008380","GO:0006397","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_010597371.2","go_terms":["GO:0030238","GO:0050810","GO:0030575","GO:0033327","GO:0000398","GO:0044830","GO:0048024","GO:0022013","GO:0070935","GO:0097222","GO:0006402","GO:0098908","GO:2000627","GO:0016120","GO:0033129","GO:0043577","GO:1902416","GO:0090503","GO:0010610","GO:1901254","GO:0010323","GO:2000637","GO:0010738","GO:0045716","GO:0071031","GO:0010587","GO:0019076","GO:0075713","GO:0019068","GO:0039702","GO:0030260","GO:0039651","GO:0015074"]},{"accession":"XP_023406077.1","go_terms":[]},{"accession":"XP_023412652.1","go_terms":["GO:0016126","GO:0032435","GO:0048633","GO:0032288","GO:0046716","GO:1902902","GO:0035038","GO:0098755","GO:0035335","GO:0043087","GO:0071442","GO:0007343","GO:0051262","GO:0046856","GO:0046855","GO:0048666","GO:0035039","GO:0071391","GO:0030259","GO:0045815","GO:0045109","GO:0031642","GO:0002233","GO:0032120"]},{"accession":"XP_064130661.1","go_terms":["GO:0048172","GO:2000311","GO:0040037","GO:0042771"]},{"accession":"XP_064130662.1","go_terms":[]},{"accession":"XP_064143911.1","go_terms":["GO:0030238","GO:0050810","GO:0030575","GO:0033327","GO:0000398","GO:0044830","GO:0048024","GO:0022013","GO:0070935","GO:0097222","GO:0006402","GO:0098908","GO:2000627","GO:0016120","GO:0033129","GO:0043577","GO:1902416","GO:0090503","GO:0010610","GO:1901254","GO:0010323","GO:2000637","GO:0010738","GO:0045716","GO:0071031","GO:0010587","GO:0019076","GO:0075713","GO:0019068","GO:0039702","GO:0030260","GO:0039651","GO:0015074"]},{"accession":"XP_064149688.1","go_terms":["GO:0000244","GO:0000245","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:0000381","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_064151636.1","go_terms":["GO:0000381","GO:0050885","GO:0030520","GO:0021942","GO:0010724","GO:0048739","GO:0048813","GO:2001014","GO:0008380","GO:0006397","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_064151637.1","go_terms":["GO:0000381","GO:0050885","GO:0030520","GO:0021942","GO:0010724","GO:0048739","GO:0048813","GO:2001014","GO:0008380","GO:0006397","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_003411797.2","go_terms":[]},{"accession":"XP_023412606.1","go_terms":["GO:0000381","GO:0050885","GO:0030520","GO:0021942","GO:0010724","GO:0048739","GO:0048813","GO:2001014","GO:0008380","GO:0006397","GO:1905663","GO:1902625","GO:0048025","GO:0048026","GO:0075522","GO:0075525","GO:0000380","GO:0016556","GO:0001825","GO:1900363","GO:0002188","GO:1903586","GO:0006406","GO:0006446","GO:0060211","GO:0031047","GO:0048255","GO:0035278","GO:0001731","GO:0010610","GO:0045292","GO:1901407","GO:0097010","GO:0006376","GO:0034462","GO:0006378"]},{"accession":"XP_003413086.2","go_terms":["GO:0070940","GO:0051209","GO:0051533","GO:0042769","GO:0006369","GO:0006378","GO:0006379","GO:0010526","GO:0000395","GO:0000380","GO:0010087","GO:0030422","GO:0035196","GO:0000389","GO:0048024","GO:0007175","GO:1904876","GO:1902570","GO:0032211","GO:0000381","GO:0051096","GO:0000390","GO:0000494","GO:0097309","GO:1904751","GO:0006370","GO:1904744","GO:0008380"]},{"accession":"XP_010594969.1","go_terms":[]},{"accession":"XP_064123718.1","go_terms":["GO:0031120","GO:0042254","GO:1904874","GO:1905323","GO:0090669","GO:0000454","GO:0000493"]}],"graph":[["XP_003413086.2","XP_003414171.1",0.717],["XP_003413086.2","XP_003417302.1",0.606],["XP_003413086.2","XP_010597371.2",0.66],["XP_003413086.2","XP_010595211.1",0.823],["XP_003413086.2","XP_010588620.2",0.773],["XP_003413086.2","XP_064130662.1",0.701],["XP_003413086.2","XP_064127119.1",0.521],["XP_003413086.2","XP_064123718.1",0.648],["XP_003413086.2","XP_023412652.1",0.593],["XP_003413086.2","XP_064151633.1",0.637],["XP_003413086.2","XP_064151636.1",0.656],["XP_003413086.2","XP_064151637.1",0.673],["XP_003413086.2","XP_064148989.1",0.855],["XP_003413086.2","XP_064149688.1",0.573],["XP_064127119.1","XP_010594969.1",0.533],["XP_064127119.1","XP_010595211.1",0.922],["XP_064127119.1","XP_010597371.2",0.732],["XP_064127119.1","XP_023406077.1",0.658],["XP_064127119.1","XP_023412606.1",0.816],["XP_064127119.1","XP_023412652.1",0.663],["XP_064127119.1","XP_064130661.1",0.546],["XP_064127119.1","XP_064130662.1",0.793],["XP_064127119.1","XP_064148989.1",0.913],["XP_064127119.1","XP_064149688.1",0.688],["XP_064127119.1","XP_064151633.1",0.839],["XP_064127119.1","XP_064151636.1",0.852],["XP_064127119.1","XP_064151637.1",0.847],["XP_064127119.1","XP_003404525.4",0.511],["XP_064127119.1","XP_003411797.2",0.71],["XP_064127119.1","XP_003414171.1",0.695],["XP_064127119.1","XP_003417302.1",0.513],["XP_064127119.1","XP_010588620.2",0.568],["XP_064151637.1","XP_010588620.2",0.748],["XP_064151637.1","XP_010594969.1",0.541],["XP_064151637.1","XP_010595211.1",0.915],["XP_064151637.1","XP_010597371.2",0.792],["XP_064151637.1","XP_023406077.1",0.837],["XP_064151637.1","XP_023412606.1",0.888],["XP_064151637.1","XP_023412652.1",0.823],["XP_064151637.1","XP_064123718.1",0.837],["XP_064151637.1","XP_064130661.1",0.921],["XP_064151637.1","XP_064130662.1",0.953],["XP_064151637.1","XP_064143911.1",0.797],["XP_064151637.1","XP_064148989.1",0.827],["XP_064151637.1","XP_064149688.1",0.781],["XP_064151637.1","XP_064151633.1",0.865],["XP_064151637.1","XP_064151636.1",0.878],["XP_064151637.1","XP_003404525.4",0.742],["XP_064151637.1","XP_003411797.2",0.88],["XP_064151637.1","XP_003414171.1",0.755],["XP_064151637.1","XP_003417302.1",0.774],["XP_023406077.1","XP_010595211.1",0.887],["XP_023406077.1","XP_010597371.2",0.505],["XP_023406077.1","XP_023412606.1",0.518],["XP_023406077.1","XP_023412652.1",0.877],["XP_023406077.1","XP_064123718.1",0.679],["XP_023406077.1","XP_064130661.1",0.702],["XP_023406077.1","XP_064130662.1",0.712],["XP_023406077.1","XP_064148989.1",0.707],["XP_023406077.1","XP_064149688.1",0.9],["XP_023406077.1","XP_064151633.1",0.743],["XP_023406077.1","XP_064151636.1",0.808],["XP_023406077.1","XP_003411797.2",0.92],["XP_023406077.1","XP_003414171.1",0.794],["XP_023406077.1","XP_003417302.1",0.728],["XP_003411797.2","XP_003417302.1",0.682],["XP_003411797.2","XP_003414171.1",0.742],["XP_003411797.2","XP_010595211.1",0.889],["XP_003411797.2","XP_010597371.2",0.543],["XP_003411797.2","XP_023412606.1",0.509],["XP_003411797.2","XP_023412652.1",0.889],["XP_003411797.2","XP_064123718.1",0.639],["XP_003411797.2","XP_064130661.1",0.878],["XP_003411797.2","XP_064130662.1",0.824],["XP_003411797.2","XP_064148989.1",0.698],["XP_003411797.2","XP_064149688.1",0.875],["XP_003411797.2","XP_064151633.1",0.73],["XP_003411797.2","XP_064151636.1",0.855],["XP_010597371.2","XP_023412606.1",0.731],["XP_010597371.2","XP_023412652.1",0.633],["XP_010597371.2","XP_064123718.1",0.605],["XP_010597371.2","XP_064130661.1",0.515],["XP_010597371.2","XP_064130662.1",0.737],["XP_010597371.2","XP_064143911.1",0.696],["XP_010597371.2","XP_064148989.1",0.927],["XP_010597371.2","XP_064149688.1",0.874],["XP_010597371.2","XP_064151633.1",0.807],["XP_010597371.2","XP_064151636.1",0.788],["XP_010597371.2","XP_003414171.1",0.848],["XP_010597371.2","XP_003417302.1",0.599],["XP_010597371.2","XP_010588620.2",0.78],["XP_010597371.2","XP_010594969.1",0.692],["XP_010597371.2","XP_010595211.1",0.865],["XP_003404525.4","XP_010595211.1",0.555],["XP_003404525.4","XP_064130662.1",0.6],["XP_003404525.4","XP_064151636.1",0.74],["XP_064151633.1","XP_010588620.2",0.617],["XP_064151633.1","XP_010595211.1",0.882],["XP_064151633.1","XP_023412606.1",0.729],["XP_064151633.1","XP_023412652.1",0.748],["XP_064151633.1","XP_064123718.1",0.641],["XP_064151633.1","XP_064130662.1",0.791],["XP_064151633.1","XP_064143911.1",0.819],["XP_064151633.1","XP_064148989.1",0.686],["XP_064151633.1","XP_064149688.1",0.724],["XP_064151633.1","XP_064151636.1",0.861],["XP_064151633.1","XP_003414171.1",0.739],["XP_064151633.1","XP_003417302.1",0.706],["XP_064148989.1","XP_010588620.2",0.902],["XP_064148989.1","XP_010595211.1",0.98],["XP_064148989.1","XP_023412606.1",0.918],["XP_064148989.1","XP_023412652.1",0.916],["XP_064148989.1","XP_064123718.1",0.946],["XP_064148989.1","XP_064130661.1",0.792],["XP_064148989.1","XP_064130662.1",0.808],["XP_064148989.1","XP_064143911.1",0.787],["XP_064148989.1","XP_064149688.1",0.53],["XP_064148989.1","XP_064151636.1",0.805],["XP_064148989.1","XP_003414171.1",0.834],["XP_064148989.1","XP_003417302.1",0.915],["XP_064130661.1","XP_010595211.1",0.821],["XP_064130661.1","XP_023412606.1",0.58],["XP_064130661.1","XP_023412652.1",0.549],["XP_064130661.1","XP_064123718.1",0.519],["XP_064130661.1","XP_064130662.1",0.904],["XP_064130661.1","XP_064151636.1",0.784],["XP_064130661.1","XP_064149688.1",0.568],["XP_064130661.1","XP_003414171.1",0.893],["XP_064149688.1","XP_010588620.2",0.523],["XP_064149688.1","XP_010594969.1",0.654],["XP_064149688.1","XP_010595211.1",0.893],["XP_064149688.1","XP_023412606.1",0.589],["XP_064149688.1","XP_023412652.1",0.697],["XP_064149688.1","XP_064123718.1",0.669],["XP_064149688.1","XP_064130662.1",0.89],["XP_064149688.1","XP_064143911.1",0.762],["XP_064149688.1","XP_064151636.1",0.713],["XP_064149688.1","XP_003414171.1",0.946],["XP_064149688.1","XP_003417302.1",0.584],["XP_064143911.1","XP_010588620.2",0.557],["XP_064143911.1","XP_010595211.1",0.806],["XP_064143911.1","XP_023412652.1",0.542],["XP_064143911.1","XP_064130662.1",0.559],["XP_064143911.1","XP_064151636.1",0.749],["XP_064143911.1","XP_003414171.1",0.819],["XP_023412652.1","XP_010595211.1",0.761],["XP_023412652.1","XP_023412606.1",0.649],["XP_023412652.1","XP_064123718.1",0.881],["XP_023412652.1","XP_064130662.1",0.753],["XP_023412652.1","XP_064151636.1",0.597],["XP_023412652.1","XP_003414171.1",0.953],["XP_023412652.1","XP_003417302.1",0.668],["XP_023412652.1","XP_010588620.2",0.729],["XP_064151636.1","XP_010588620.2",0.776],["XP_064151636.1","XP_010595211.1",0.893],["XP_064151636.1","XP_023412606.1",0.779],["XP_064151636.1","XP_064123718.1",0.812],["XP_064151636.1","XP_064130662.1",0.864],["XP_064151636.1","XP_003414171.1",0.786],["XP_064151636.1","XP_003417302.1",0.649],["XP_064130662.1","XP_010594969.1",0.77],["XP_064130662.1","XP_010595211.1",0.956],["XP_064130662.1","XP_023412606.1",0.742],["XP_064130662.1","XP_064123718.1",0.701],["XP_064130662.1","XP_003414171.1",0.983],["XP_064130662.1","XP_003417302.1",0.731],["XP_064130662.1","XP_010588620.2",0.515],["XP_010595211.1","XP_064123718.1",0.811],["XP_010595211.1","XP_023412606.1",0.754],["XP_010595211.1","XP_003414171.1",0.938],["XP_010595211.1","XP_003417302.1",0.825],["XP_010595211.1","XP_010588620.2",0.844],["XP_010595211.1","XP_010594969.1",0.719],["XP_064123718.1","XP_003414171.1",0.808],["XP_064123718.1","XP_003417302.1",0.766],["XP_064123718.1","XP_010588620.2",0.699],["XP_010588620.2","XP_003414171.1",0.59],["XP_010588620.2","XP_003417302.1",0.759],["XP_010588620.2","XP_010594969.1",0.517],["XP_010588620.2","XP_023412606.1",0.723],["XP_010594969.1","XP_003414171.1",0.744],["XP_003414171.1","XP_003417302.1",0.932],["XP_003414171.1","XP_023412606.1",0.775],["XP_003417302.1","XP_023412606.1",0.653]],"all_go_terms":{"GO:0055114":1,"GO:0001320":1,"GO:0010447":1,"GO:0071291":1,"GO:0048773":1,"GO:0003069":1,"GO:0001302":1,"GO:0019430":1,"GO:0006406":8,"GO:0000380":9,"GO:0060211":8,"GO:0045292":8,"GO:0016556":8,"GO:0002188":8,"GO:0000381":9,"GO:0006376":8,"GO:0060213":1,"GO:0048026":8,"GO:0097010":8,"GO:0007310":1,"GO:0008069":1,"GO:0046011":1,"GO:0002931":1,"GO:0061158":1,"GO:0045451":1,"GO:0071230":1,"GO:0001731":8,"GO:1903586":8,"GO:0048025":8,"GO:0010610":10,"GO:1900248":1,"GO:1905663":8,"GO:0032869":1,"GO:0006446":8,"GO:1901407":8,"GO:0048255":8,"GO:1900365":1,"GO:0071456":1,"GO:1902625":8,"GO:0075525":8,"GO:0035278":8,"GO:1900363":8,"GO:0006378":9,"GO:0031047":8,"GO:0075522":8,"GO:0001825":8,"GO:0034462":8,"GO:0007343":2,"GO:0046856":2,"GO:0048633":2,"GO:0016126":2,"GO:0030259":2,"GO:0002233":2,"GO:0035039":2,"GO:0071442":2,"GO:0098755":2,"GO:0048666":2,"GO:0043087":2,"GO:0032435":2,"GO:0046716":2,"GO:0035038":2,"GO:0046855":2,"GO:1902902":2,"GO:0031642":2,"GO:0032120":2,"GO:0032288":2,"GO:0045109":2,"GO:0051262":2,"GO:0071391":2,"GO:0045815":2,"GO:0035335":2,"GO:0010724":5,"GO:0006397":5,"GO:0021942":5,"GO:0048813":5,"GO:0050885":5,"GO:0008380":6,"GO:2001014":5,"GO:0030520":5,"GO:0048739":5,"GO:0021510":1,"GO:0001935":1,"GO:0002040":1,"GO:0001837":1,"GO:0061053":1,"GO:1905590":1,"GO:0032332":1,"GO:0060021":1,"GO:0035904":1,"GO:0018057":1,"GO:0030324":1,"GO:2001046":1,"GO:0048514":1,"GO:0043542":1,"GO:0030199":1,"GO:0046688":1,"GO:0018277":1,"GO:2000329":1,"GO:0048251":1,"GO:0045071":1,"GO:0000398":3,"GO:0007283":1,"GO:0007638":1,"GO:0006955":1,"GO:0007286":1,"GO:0051533":2,"GO:0006369":2,"GO:0006379":2,"GO:0070940":2,"GO:0051209":2,"GO:0010526":2,"GO:0042769":2,"GO:0033327":2,"GO:0097222":2,"GO:0030238":2,"GO:0070935":2,"GO:0090503":2,"GO:0010738":2,"GO:0039702":2,"GO:2000627":2,"GO:0075713":2,"GO:2000637":2,"GO:0033129":2,"GO:0039651":2,"GO:0071031":2,"GO:0022013":2,"GO:0098908":2,"GO:0015074":2,"GO:0010587":2,"GO:0050810":2,"GO:0019076":2,"GO:0044830":2,"GO:1902416":2,"GO:0006402":2,"GO:0030575":2,"GO:1901254":2,"GO:0030260":2,"GO:0045716":2,"GO:0010323":2,"GO:0019068":2,"GO:0048024":3,"GO:0043577":2,"GO:0016120":2,"GO:0048172":1,"GO:0040037":1,"GO:2000311":1,"GO:0042771":1,"GO:0000245":1,"GO:0000244":1,"GO:0035196":1,"GO:1902570":1,"GO:0010087":1,"GO:0030422":1,"GO:1904751":1,"GO:1904744":1,"GO:0032211":1,"GO:0000389":1,"GO:0006370":1,"GO:0000395":1,"GO:0000494":1,"GO:0097309":1,"GO:0007175":1,"GO:0000390":1,"GO:1904876":1,"GO:0051096":1,"GO:0090669":1,"GO:1905323":1,"GO:0042254":1,"GO:0000454":1,"GO:1904874":1,"GO:0031120":1,"GO:0000493":1},"recipe_readded":[]}