{"hash":"1366683434574251918","title":"Neural and Muscle Excitability Signaling","description":"This cluster centers on proteins involved in excitability and signaling across nervous, muscular, and cardiac tissues, highlighted by ion channel activity, membrane repolarization, and regulation of action potentials. Hormonal responses (testosterone, estradiol) and neurotransmitter handling (glutamate reuptake) fit the theme of modulating signaling in excitable cells, with CNS myelination and heart-rate regulation further reinforcing a broad neural-muscle system connectivity. Overall, the shared function appears to be modulation of membrane potential and excitability in neurons, muscles, and heart.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"members":[{"accession":"XP_003417333.1","go_terms":["GO:0050976","GO:0030322","GO:0071805","GO:0098914","GO:0030007","GO:0060075","GO:0051289","GO:0060306","GO:0035220","GO:0051935","GO:0022010","GO:0046676","GO:0010107","GO:0048169","GO:0032355","GO:0086002","GO:0071356","GO:0015693","GO:0051877","GO:0051876","GO:0071316","GO:0071333","GO:0086091","GO:0014861","GO:0090099","GO:0055119","GO:0002931","GO:0050877","GO:1905965","GO:0090076","GO:0033574","GO:0043330","GO:2001259","GO:0033198","GO:1990573"]},{"accession":"XP_003417463.1","go_terms":["GO:0051289","GO:0060306","GO:0035220","GO:0051935","GO:0022010","GO:0046676","GO:0010107","GO:0048169","GO:0032355","GO:0086002","GO:0071356","GO:0015693","GO:0051877","GO:0051876","GO:0071316","GO:0071333","GO:0086091","GO:0014861","GO:0090099","GO:0055119","GO:0060075","GO:0002931","GO:0050877","GO:1905965","GO:0090076","GO:0033574","GO:0098914","GO:0043330","GO:2001259","GO:0033198","GO:1990573"]},{"accession":"XP_064131858.1","go_terms":["GO:0006655","GO:0006646","GO:1905711","GO:0010512","GO:0006659","GO:0070317","GO:0006663"]}],"graph":[["XP_003417463.1","XP_003417333.1",0.968],["XP_003417463.1","XP_064131858.1",0.983],["XP_003417333.1","XP_064131858.1",0.982]],"all_go_terms":{"GO:0033574":2,"GO:0071316":2,"GO:0051935":2,"GO:0090076":2,"GO:0086091":2,"GO:0022010":2,"GO:2001259":2,"GO:0014861":2,"GO:0032355":2,"GO:0071805":1,"GO:0060306":2,"GO:1990573":2,"GO:0098914":2,"GO:0050976":1,"GO:0030322":1,"GO:0002931":2,"GO:0035220":2,"GO:0048169":2,"GO:0086002":2,"GO:0051876":2,"GO:0051289":2,"GO:0055119":2,"GO:0015693":2,"GO:0060075":2,"GO:0046676":2,"GO:0090099":2,"GO:0043330":2,"GO:0010107":2,"GO:0050877":2,"GO:0071333":2,"GO:0051877":2,"GO:0071356":2,"GO:1905965":2,"GO:0033198":2,"GO:0030007":1,"GO:0006663":1,"GO:0010512":1,"GO:0006655":1,"GO:0006646":1,"GO:0070317":1,"GO:1905711":1,"GO:0006659":1},"recipe_readded":[]}